14 CFR 121.687 - Dispatch release: Flag and domestic operations.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Dispatch release: Flag and domestic operations. 121.687 Section 121.687 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF...) The dispatch release must contain, or have attached to it, weather reports, available weather...

14 CFR 121.687 - Dispatch release: Flag and domestic operations.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Dispatch release: Flag and domestic operations. 121.687 Section 121.687 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF...) The dispatch release must contain, or have attached to it, weather reports, available weather...

14 CFR 121.687 - Dispatch release: Flag and domestic operations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Dispatch release: Flag and domestic operations. 121.687 Section 121.687 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF...) The dispatch release must contain, or have attached to it, weather reports, available weather...

14 CFR § 1213.106 - Preventing release of classified information to the media.

Code of Federal Regulations, 2014 CFR

2014-01-01

... information to the media. § 1213.106 Section § 1213.106 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS AND INFORMATION MEDIA § 1213.106 Preventing release of classified information to the media. (a) Release of classified information in any form (e.g., documents, through...

14 CFR 1213.103 - Responsibilities.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Responsibilities. 1213.103 Section 1213.103 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS AND... news releases and other types of public information will be issued nationwide by NASA Headquarters...

14 CFR 1213.103 - Responsibilities.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Responsibilities. 1213.103 Section 1213.103 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS AND... news releases and other types of public information will be issued nationwide by NASA Headquarters...

14 CFR 1213.103 - Responsibilities.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Responsibilities. 1213.103 Section 1213.103 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS AND... news releases and other types of public information will be issued nationwide by NASA Headquarters...

14 CFR 1213.103 - Responsibilities.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Responsibilities. 1213.103 Section 1213.103 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS AND... news releases and other types of public information will be issued nationwide by NASA Headquarters...

14 CFR 1213.105 - Interviews.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Interviews. 1213.105 Section 1213.105 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS AND INFORMATION MEDIA § 1213.105 Interviews. (a) Only spokespersons designated by the Assistant Administrator for...

14 CFR 1213.105 - Interviews.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Interviews. 1213.105 Section 1213.105 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS AND INFORMATION MEDIA § 1213.105 Interviews. (a) Only spokespersons designated by the Assistant Administrator for...

14 CFR 125.361 - Flight release under IFR or over-the-top.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Flight release under IFR or over-the-top. 125.361 Section 125.361 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... release an airplane for operations under IFR or over-the-top unless appropriate weather reports or...

14 CFR 125.361 - Flight release under IFR or over-the-top.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Flight release under IFR or over-the-top. 125.361 Section 125.361 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... release an airplane for operations under IFR or over-the-top unless appropriate weather reports or...

14 CFR 125.361 - Flight release under IFR or over-the-top.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Flight release under IFR or over-the-top. 125.361 Section 125.361 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... release an airplane for operations under IFR or over-the-top unless appropriate weather reports or...

14 CFR 125.361 - Flight release under IFR or over-the-top.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Flight release under IFR or over-the-top. 125.361 Section 125.361 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... release an airplane for operations under IFR or over-the-top unless appropriate weather reports or...

14 CFR 125.361 - Flight release under IFR or over-the-top.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Flight release under IFR or over-the-top. 125.361 Section 125.361 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... release an airplane for operations under IFR or over-the-top unless appropriate weather reports or...

14 CFR 1213.100 - Scope.

Code of Federal Regulations, 2011 CFR

2011-01-01

... and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS AND INFORMATION... is defined as information in any form provided to news and information media, especially information..., but are not limited to, press releases, media advisories, news features, and Web postings. Not...

14 CFR § 1213.105 - Interviews.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Interviews. § 1213.105 Section § 1213.105 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS AND INFORMATION MEDIA § 1213.105 Interviews. (a) Only spokespersons designated by the Assistant Administrator for...

14 CFR § 1213.107 - Preventing unauthorized release of sensitive but unclassified (SBU) information/material to the...

Code of Federal Regulations, 2014 CFR

2014-01-01

... sensitive but unclassified (SBU) information/material to the news media. § 1213.107 Section § 1213.107 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS AND.../material to the news media. (a) All NASA SBU information requires accountability and approval for release...

14 CFR § 1213.100 - Scope.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS AND..., which is defined as information in any form provided to news and information media, especially... include, but are not limited to, press releases, media advisories, news features, and Web postings. Not...

14 CFR 1213.100 - Scope.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS AND..., which is defined as information in any form provided to news and information media, especially... include, but are not limited to, press releases, media advisories, news features, and Web postings. Not...

14 CFR 1213.100 - Scope.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS AND..., which is defined as information in any form provided to news and information media, especially... include, but are not limited to, press releases, media advisories, news features, and Web postings. Not...

14 CFR 125.359 - Flight release under VFR.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Flight release under VFR. 125.359 Section 125.359 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED... visibility en route, as indicated by available weather reports or forecasts, or any combination thereof, are...

14 CFR 125.359 - Flight release under VFR.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Flight release under VFR. 125.359 Section 125.359 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED... visibility en route, as indicated by available weather reports or forecasts, or any combination thereof, are...

14 CFR 121.611 - Dispatch or flight release under VFR.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Dispatch or flight release under VFR. 121.611 Section 121.611 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... operation unless the ceiling and visibility en route, as indicated by available weather reports or forecasts...

14 CFR 121.611 - Dispatch or flight release under VFR.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Dispatch or flight release under VFR. 121.611 Section 121.611 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... operation unless the ceiling and visibility en route, as indicated by available weather reports or forecasts...

14 CFR 121.611 - Dispatch or flight release under VFR.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Dispatch or flight release under VFR. 121.611 Section 121.611 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... operation unless the ceiling and visibility en route, as indicated by available weather reports or forecasts...

14 CFR 121.611 - Dispatch or flight release under VFR.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Dispatch or flight release under VFR. 121.611 Section 121.611 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... operation unless the ceiling and visibility en route, as indicated by available weather reports or forecasts...

14 CFR 121.611 - Dispatch or flight release under VFR.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Dispatch or flight release under VFR. 121.611 Section 121.611 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... operation unless the ceiling and visibility en route, as indicated by available weather reports or forecasts...

Vesicular and non-vesicular glutamate release in the nucleus accumbens in conditions of a forced change of behavioral strategy.

PubMed

Saul'skaya, N B; Mikhailova, M O

2005-09-01

Studies on Sprague-Dawley rats used intracerebral dialysis and high-performance liquid chromatography to identify sources of glutamate release into the intercellular space of the nucleus accumbens during forced correction of food-related behavior, i.e., on presentation to the feeding rat of a conditioned signal previously combined with a pain stimulus or on replacement of a food reinforcement with an inedible food substitute. The results showed that glutamate release observed in the nucleus accumbens during these tests can be prevented by tetrodotoxin (1 microM), which blocks exocytosis, but not by (S)-4-carboxyphenylglycine (5 microM), which blocks non-vesicular glutamate release. Conversely, administration of (S)-4-carboxyphenylglycine halved baseline glutamate release, while administration of tetrodotoxin had no effect on this process. These data provide evidence that different mechanisms control glutamate release into the intercellular space of this nucleus in baseline conditions and in conditions of evoked correction of feeding behavior: the source of baseline glutamate release is non-vesicular glutamate release, while glutamate release seen during forced correction of feeding behavior results from increases in synaptic release.

14 CFR § 1213.109 - News releases concerning international activities.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false News releases concerning international... ADMINISTRATION RELEASE OF INFORMATION TO NEWS AND INFORMATION MEDIA § 1213.109 News releases concerning... report all visits proposed by representatives of foreign news media to the Public Affairs Officer of the...

14 CFR 121.615 - Dispatch or flight release over water: Flag and supplemental operations.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Dispatch or flight release over water: Flag and supplemental operations. 121.615 Section 121.615 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS AND OPERATORS FOR COMPENSATION OR HIRE: CERTIFICATION AND OPERATIONS OPERATING...

14 CFR 121.613 - Dispatch or flight release under IFR or over the top.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Dispatch or flight release under IFR or over the top. 121.613 Section 121.613 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT... appropriate weather reports or forecasts, or any combination thereof, indicate that the weather conditions...

14 CFR 121.613 - Dispatch or flight release under IFR or over the top.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Dispatch or flight release under IFR or over the top. 121.613 Section 121.613 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT... appropriate weather reports or forecasts, or any combination thereof, indicate that the weather conditions...

14 CFR 121.613 - Dispatch or flight release under IFR or over the top.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Dispatch or flight release under IFR or over the top. 121.613 Section 121.613 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT... appropriate weather reports or forecasts, or any combination thereof, indicate that the weather conditions...

14 CFR 121.613 - Dispatch or flight release under IFR or over the top.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Dispatch or flight release under IFR or over the top. 121.613 Section 121.613 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT... appropriate weather reports or forecasts, or any combination thereof, indicate that the weather conditions...

14 CFR 121.613 - Dispatch or flight release under IFR or over the top.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Dispatch or flight release under IFR or over the top. 121.613 Section 121.613 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT... appropriate weather reports or forecasts, or any combination thereof, indicate that the weather conditions...

14 CFR 1203.404 - Handling of unprocessed data.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Section 1203.404 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY... resort to security classification to prevent premature release. However, if at any time during the... security classification. ...

14 CFR 1203.404 - Handling of unprocessed data.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Section 1203.404 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY... resort to security classification to prevent premature release. However, if at any time during the... security classification. ...

Index to NASA news releases and speeches, 1984

NASA Technical Reports Server (NTRS)

1985-01-01

The Index to NASA News Releases and Speeches (1984) contains selected speeches and news releases issued by NASA Headquarters during the year 1984. The index was prepared by the NASA Scientific and Technical Information Facility operated for the National Aeronautical and Space Administration by PRC Government Information Systems.

14 CFR 1212.202 - Identification procedures.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Identification procedures. 1212.202 Section 1212.202 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PRIVACY ACT-NASA REGULATIONS Access to Records § 1212.202 Identification procedures. (a) The system manager will release...

14 CFR 1212.202 - Identification procedures.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Identification procedures. 1212.202 Section 1212.202 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PRIVACY ACT-NASA REGULATIONS Access to Records § 1212.202 Identification procedures. (a) The system manager will release...

14 CFR 1213.101 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Applicability. 1213.101 Section 1213.101 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS AND INFORMATION MEDIA § 1213.101 Applicability. (a) This policy applies to NASA Headquarters, NASA Centers, and...

14 CFR 1213.101 - Applicability.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Applicability. 1213.101 Section 1213.101 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS AND INFORMATION MEDIA § 1213.101 Applicability. (a) This policy applies to NASA Headquarters, NASA Centers, and...

14 CFR 1213.101 - Applicability.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Applicability. 1213.101 Section 1213.101 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS AND INFORMATION MEDIA § 1213.101 Applicability. (a) This policy applies to NASA Headquarters, NASA Centers, and...

14 CFR 1213.101 - Applicability.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Applicability. 1213.101 Section 1213.101 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS AND INFORMATION MEDIA § 1213.101 Applicability. (a) This policy applies to NASA Headquarters, NASA Centers, and...

14 CFR § 1213.101 - Applicability.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Applicability. § 1213.101 Section § 1213.101 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS AND INFORMATION MEDIA § 1213.101 Applicability. (a) This policy applies to NASA Headquarters, NASA...

14 CFR 1213.102 - Policy.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Policy. 1213.102 Section 1213.102 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS AND INFORMATION MEDIA § 1213.102 Policy. (a) NASA, a scientific and technical Agency, is committed to a culture of...

14 CFR 1213.102 - Policy.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Policy. 1213.102 Section 1213.102 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS AND INFORMATION MEDIA § 1213.102 Policy. (a) NASA, a scientific and technical Agency, is committed to a culture of...

14 CFR 15.109 - Settlements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Settlements. 15.109 Section 15.109 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL RULES... Department of Justice, approves the proposed settlement. (3) The publisher submits a signed release that...

14 CFR 15.109 - Settlements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Settlements. 15.109 Section 15.109 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL RULES... Department of Justice, approves the proposed settlement. (3) The publisher submits a signed release that...

14 CFR 15.109 - Settlements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Settlements. 15.109 Section 15.109 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL RULES... Department of Justice, approves the proposed settlement. (3) The publisher submits a signed release that...

14 CFR 15.109 - Settlements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Settlements. 15.109 Section 15.109 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL RULES... Department of Justice, approves the proposed settlement. (3) The publisher submits a signed release that...

14 CFR 15.109 - Settlements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Settlements. 15.109 Section 15.109 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL RULES... Department of Justice, approves the proposed settlement. (3) The publisher submits a signed release that...

NASA in Crisis: The Space Agency's Public Relations Efforts Regarding the Hubble Space Telescope.

ERIC Educational Resources Information Center

Kauffman, James

1997-01-01

Examines the National Aeronautics and Space Administration's (NASA) public relations efforts concerning the Hubble telescope. Proposes that NASA's poor public relations exacerbated problems: NASA oversold the telescope before it was deployed, failed to develop a plan for release of images, provided misleading flight reports, and reported…

14 CFR § 1213.102 - Policy.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Policy. § 1213.102 Section § 1213.102 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS AND INFORMATION MEDIA § 1213.102 Policy. (a) NASA, a scientific and technical Agency, is committed to a culture of...

14 CFR 31.51 - Ballast.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Ballast. 31.51 Section 31.51 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... means for the safe storage and controlled release of ballast. The ballast must consist of material that...

14 CFR 31.51 - Ballast.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Ballast. 31.51 Section 31.51 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... means for the safe storage and controlled release of ballast. The ballast must consist of material that...

14 CFR 1213.108 - Multimedia materials.

Code of Federal Regulations, 2013 CFR

2013-01-01

....108 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS... original or duplicate files of news-oriented imagery and other digital multimedia material generated within... the opinion of the installations, would be appropriate for use as news feed material or features in...

14 CFR 1213.108 - Multimedia materials.

Code of Federal Regulations, 2011 CFR

2011-01-01

....108 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS... original or duplicate files of news-oriented imagery and other digital multimedia material generated within... the opinion of the installations, would be appropriate for use as news feed material or features in...

14 CFR 1213.108 - Multimedia materials.

Code of Federal Regulations, 2012 CFR

2012-01-01

....108 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS... original or duplicate files of news-oriented imagery and other digital multimedia material generated within... the opinion of the installations, would be appropriate for use as news feed material or features in...

14 CFR 1213.108 - Multimedia materials.

Code of Federal Regulations, 2010 CFR

2010-01-01

....108 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS... original or duplicate files of news-oriented imagery and other digital multimedia material generated within... the opinion of the installations, would be appropriate for use as news feed material or features in...

Upgraded Hubble Space Telescope Images

NASA Image and Video Library

2009-09-08

NASA Associate Administrator of the Science Mission Directorate Dr. Edward J. Weiler discusses newly released images from NASA's Hubble Space Telescope Wednesday, Sept. 9, 2009 at NASA Headquarters in Washington. The images were from four of the telescopes' six operating science instruments. Photo Credit: (NASA/Bill Ingalls)

Space Station Freedom (SSF) Data Management System (DMS) performance model data base

NASA Technical Reports Server (NTRS)

Stovall, John R.

1993-01-01

The purpose of this document was originally to be a working document summarizing Space Station Freedom (SSF) Data Management System (DMS) hardware and software design, configuration, performance and estimated loading data from a myriad of source documents such that the parameters provided could be used to build a dynamic performance model of the DMS. The document is published at this time as a close-out of the DMS performance modeling effort resulting from the Clinton Administration mandated Space Station Redesign. The DMS as documented in this report is no longer a part of the redesigned Space Station. The performance modeling effort was a joint undertaking between the National Aeronautics and Space Administration (NASA) Johnson Space Center (JSC) Flight Data Systems Division (FDSD) and the NASA Ames Research Center (ARC) Spacecraft Data Systems Research Branch. The scope of this document is limited to the DMS core network through the Man Tended Configuration (MTC) as it existed prior to the 1993 Clinton Administration mandated Space Station Redesign. Data is provided for the Standard Data Processors (SDP's), Multiplexer/Demultiplexers (MDM's) and Mass Storage Units (MSU's). Planned future releases would have added the additional hardware and software descriptions needed to describe the complete DMS. Performance and loading data through the Permanent Manned Configuration (PMC) was to have been included as it became available. No future releases of this document are presently planned pending completion of the present Space Station Redesign activities and task reassessment.

10 CFR 2.1005 - Exclusions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... administration, such as material related to budgets, financial management, personnel, office space, general...; (d) Press clippings and press releases; (e) Junk mail; (f) References cited in contractor reports...

10 CFR 2.1005 - Exclusions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... administration, such as material related to budgets, financial management, personnel, office space, general...; (d) Press clippings and press releases; (e) Junk mail; (f) References cited in contractor reports...

10 CFR 2.1005 - Exclusions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... administration, such as material related to budgets, financial management, personnel, office space, general...; (d) Press clippings and press releases; (e) Junk mail; (f) References cited in contractor reports...

14 CFR 155.13 - Determinations by FAA.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Determinations by FAA. 155.13 Section 155.13 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED... it might prejudice the needs and interests of the armed forces. Upon a determination that the release...

14 CFR 121.633 - Considering time-limited systems in planning ETOPS alternates.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Flight Release Rules § 121.633 Considering time-limited systems in planning ETOPS alternates. (a) For... planning ETOPS alternates. 121.633 Section 121.633 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... dispatch or flight release if the time needed to fly to that airport (at the approved one-engine...

14 CFR 121.633 - Considering time-limited systems in planning ETOPS alternates.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Flight Release Rules § 121.633 Considering time-limited systems in planning ETOPS alternates. (a) For... planning ETOPS alternates. 121.633 Section 121.633 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... dispatch or flight release if the time needed to fly to that airport (at the approved one-engine...

14 CFR 121.633 - Considering time-limited systems in planning ETOPS alternates.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Flight Release Rules § 121.633 Considering time-limited systems in planning ETOPS alternates. (a) For... planning ETOPS alternates. 121.633 Section 121.633 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... dispatch or flight release if the time needed to fly to that airport (at the approved one-engine...

14 CFR 121.633 - Considering time-limited systems in planning ETOPS alternates.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Flight Release Rules § 121.633 Considering time-limited systems in planning ETOPS alternates. (a) For... planning ETOPS alternates. 121.633 Section 121.633 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... dispatch or flight release if the time needed to fly to that airport (at the approved one-engine...

14 CFR 121.633 - Considering time-limited systems in planning ETOPS alternates.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Flight Release Rules § 121.633 Considering time-limited systems in planning ETOPS alternates. (a) For... planning ETOPS alternates. 121.633 Section 121.633 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... dispatch or flight release if the time needed to fly to that airport (at the approved one-engine...

77 FR 18305 - Agency Information Collection; Activity Under OMB Review; Report of Passengers Denied Confirmed...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-27

... Confirmed Space--BTS Form 251 AGENCY: Research & Innovative Technology Administration (RITA), Bureau of... Title: Report of Passengers Denied Confirmed Space. Form No.: BTS Form 251. Type of Review... operational difficulties. Because the rate of denied boarding is released quarterly, travelers and travel...

78 FR 60997 - Agency Information Collection: Activity Under OMB Review: Report of Passengers Denied Confirmed...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-02

... Confirmed Space--BTS Form 251 AGENCY: Research & Innovative Technology Administration (RITA), Bureau of... Confirmed Space. Form No.: BTS Form 251. Type of Review: Re-instatement of an expired collection... boarding is released quarterly, travelers and travel agents can select carriers with lower incidences of...

Upgraded Hubble Space Telescope Images

NASA Image and Video Library

2009-09-08

NASA Associate Administrator of the Science Mission Directorate Dr. Edward J. Weiler listens to a reporters question during a press conference where NASA released images from NASA's Hubble Space Telescope Wednesday, Sept. 9, 2009 at NASA Headquarters in Washington. The images were from four of the telescopes' six operating science instruments. Photo Credit: (NASA/Bill Ingalls)

78 FR 43272 - Agency Information Collection; Activity Under OMB Review; Report of Passengers Denied Confirmed...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-19

... Confirmed Space--BTS Form 251 AGENCY: Research & Innovative Technology Administration (RITA), Bureau of...: Report of Passengers Denied Confirmed Space. Form No.: BTS Form 251. Type of Review: Reinstatement of an.... Because the rate of denied boarding is released quarterly, travelers and travel agents can select carriers...

Asteroid Detection Results Using the Space Surveillance Telescope

DTIC Science & Technology

2015-10-18

Distribution Statement A: Approved for public release, distribution unlimited. Asteroid Detection Results Using the Space Surveillance Telescope...issued a series of directives to the National Air and Space Administration (NASA), setting Near-Earth Asteroid (NEA) search and discovery targets in...order to protect the Earth and its inhabitants from the threat of asteroid impact. The focus of the original 1998 Congressional mandate was to catalog

Two Stage Repair of Composite Craniofacial Defects with Antibiotic Releasing Porous Poly(methyl methacrylate) Space Maintainers and Bone Regeneration

NASA Astrophysics Data System (ADS)

Spicer, Patrick

Craniofacial defects resulting from trauma and resection present many challenges to reconstruction due to the complex structure, combinations of tissues, and environment, with exposure to the oral, skin and nasal mucosal pathogens. Tissue engineering seeks to regenerate the tissues lost in these defects; however, the composite nature and proximity to colonizing bacteria remain difficult to overcome. Additionally, many tissue engineering approaches have further hurdles to overcome in the regulatory process to clinical translation. As such these studies investigated a two stage strategy employing an antibiotic-releasing porous polymethylmethacrylate space maintainer fabricated with materials currently part of products approved or cleared by the United States Food and Drug Administration, expediting the translation to the clinic. This porous space maintainer holds the bone defect open allowing soft tissue to heal around the defect. The space maintainer can then be removed and one regenerated in the defect. These studies investigated the individual components of this strategy. The porous space maintainer showed similar soft tissue healing and response to non-porous space maintainers in a rabbit composite tissue defect. The antibiotic-releasing space maintainers showed release of antibiotics from 1-5 weeks, which could be controlled by loading and fabrication parameters. In vivo, space maintainers releasing a high dose of antibiotics for an extended period of time increased soft tissue healing over burst release space maintainers in an infected composite tissue defect model in a rabbit mandible. Finally, stabilization of bone defects and regeneration could be improved through scaffold structures and delivery of a bone forming growth factor. These studies illustrate the possibility of the two stage strategy for repair of composite tissue defects of the craniofacial complex.

Development of Electro-Optical Standard Processes for Application

DTIC Science & Technology

2011-11-01

AERONAUTICS AND SPACE ADMINISTRATION DISTRIBUTION A: APPROVED FOR PUBLIC RELEASE DISTRIBUTION IS UNLIMITED Report Documentation Page Form ApprovedOMB No...0704-0188 Public reporting burden for the collection of information is estimated to average 1 hour per response, including the time for reviewing...DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release; distribution unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Defines the process of

Report of Apollo 204 Review Board to the Administrator, National Aeronautics and Space Administration . Appendix F ; Schedule of Physical Evidence

NASA Technical Reports Server (NTRS)

1967-01-01

Immediately following the Apollo 204 accident of January 27, 1961. all associated equipment and material were impounded. Release of this equipment and material for normal use was under the close control of the Apollo 204 Review Board. Apollo Review Board Administrative Procedure No. 11, February 11, 1961, established the Apollo 204 Review Board Material Release Record (MRR). This MRR was the official form used to release material from full impoundment and was valid only after being approved by the Board and signed by a Member. The form was used as the authority to place any impounded item into one of the three Categories defined in Administrative Procedure No. 11. This appendix contains all of the authorized MRR's. Each item submitted on an MRR was given a control number; a description, including the part number and serial number; the relevance and location to the accident; any constraints before release; and the control category. The categories placed on the equipment were as follows: Category A - Items which may have a significant influence or bearing on the results or findings of the Apollo 204 Review Board; Category B - All material other than Category A which is considered relevant to the Apollo 204 Review Board investigation; Category C - Material released from Board jurisdiction. Several classes of equipment were released by special Board action prior to the establishment of the MRR system. The operating procedure for release of these classes is Enclosure F-l to this appendix.

Advancing the Journey to Mars on This Week @NASA – October 30, 2015

NASA Image and Video Library

2015-10-30

During an Oct. 28 keynote speech at the Center for American Progress, in Washington, NASA Administrator Charlie Bolden spoke about the advancement made on the journey to Mars and what lies ahead for future administrations and policy makers. NASA’s recently released report “Journey to Mars: Pioneering Next Steps in Space Exploration,” outlines its plan to reach Mars in phases – with technology demonstrations and research aboard the International Space Station, followed by hardware and procedure development in the proving ground around the moon, before sending humans to the Red Planet. Also, Space station spacewalk, Another record in space for Kelly, Mars Landing Sites/ Exploration Zones Workshop, Cassini’s “deep dive” flyby and more!

Former Administration Building

NASA Image and Video Library

2016-10-27

This archival image was released as part of a gallery comparing JPL's past and present, commemorating the 80th anniversary of NASA's Jet Propulsion Laboratory on Oct. 31, 2016. Building 11, one of the oldest buildings on lab, was once JPL's central administration building. It is now the Space Sciences Laboratory. This picture dates back to May 1943. http://photojournal.jpl.nasa.gov/catalog/PIA21201

National Space Transportation Policy: Issues for Congress

NASA Astrophysics Data System (ADS)

1995-05-01

This report, prepared for the House Committee on Science, is the first in a broad assessment of the health and future prospects of the U.S. space transportation technology and industrial base. The report focuses on the Clinton Administration's National Space Transportation Policy, which was released last fall. It examines administration policy in light of the implementation plans prepared by NASA, DOD, and the Transportation and Commerce Departments. The policy also emphasizes the important contribution private industry can make to the direction and development of U.S. space transportation capabilities. However, an analysis of the policy and implementation plans also raises some issues that might be of interest to Congress as it debates space transportation legislation, oversight, and funding. These issues involve decisions on NASA and DOD development programs, the use of foreign launch vehicles, and the new role of the private sector in space transportation research and development decisionmaking. This report also identifies two issues omitted from the Administration's policy: the preservation of long-range ballistic missile capabilities after final production in 2005, and the perspective of lower industrial tier firms toward national space transportation policy.

Project Mercury: Man-In-Space Program of the National Aeronautics and Space Administration. [Report of the Committee on Aeronautical and Space Sciences United States Senate

NASA Technical Reports Server (NTRS)

1959-01-01

The purpose of this staff study, made at the request of the chairman, is to serve members of the Committee on Aeronautical and Space Sciences as a source of basic information on Project Mercury, the man-in-space program of the National Aeronautics and Space Administration. The study is largely derived from unclassified information released by the National Aeronautics and Space Administration and testimony concerning Project Mercury given during hearings before this committee. The program descriptions are based upon current program planning. Since this is a highly advanced research and development program, the project is obviously subject to changes that may result from future developments and accomplishments characteristic of such research activities. Certain information with respect to revised schedules, obtained on a classified basis by the committee during inspection trips, is necessarily omitted. The appendixes to the study include information that may prove helpful on various aspects of space flight and exploration. Included are unofficial comments and observations relating to Russia's manned space flight activities and also a complete chronology of all satellites, lunar probes, and space probes up to the present.

Human Space Flight Plans Committee Report

NASA Image and Video Library

2009-10-21

U.S. Human Space Flight Plans Committee member Ed Crawley, right, answers a reporter's question during a press conference where the committee released it's report on Thursday, Oct., 22, 2009 at the National Press Club in Washington. The Obama Administration tasked the committee to do an independent review of planned U.S. human space flight activities with the goal of ensuring that the nation is on a vigorous and sustainable path to achieving its boldest aspirations in space. Photo Credit: (NASA/Bill Ingalls)

Human Space Flight Plans Committee Report

NASA Image and Video Library

2009-10-21

U.S. Human Space Flight Plans Committee member Ed Crawley answers a reporter's question during a press conference where the committee released it's report on Thursday, Oct., 22, 2009 at the National Press Club in Washington. The Obama Administration tasked the committee to do an independent review of planned U.S. human space flight activities with the goal of ensuring that the nation is on a vigorous and sustainable path to achieving its boldest aspirations in space. Photo Credit: (NASA/Bill Ingalls)

Human Space Flight Plans Committee Report

NASA Image and Video Library

2009-10-21

Copies of the U.S. Human Space Flight Plans Committee report are seen at a press conference where the committee released it's report findings on Thursday, Oct., 22, 2009 at the National Press Club in Washington. The Obama Administration tasked the committee to do an independent review of planned U.S. human space flight activities with the goal of ensuring that the nation is on a vigorous and sustainable path to achieving its boldest aspirations in space. Photo Credit: (NASA/Bill Ingalls)

Human Space Flight Plans Committee Report

NASA Image and Video Library

2009-10-21

Chairman of the U.S. Human Space Flight Plans Committee Norman Augustine, center, listens to reporters questions during a press conference where the committee released it's report on Thursday, Oct., 22, 2009 at the National Press Club in Washington. The Obama Administration tasked the committee to do an independent review of planned U.S. human space flight activities with the goal of ensuring that the nation is on a vigorous and sustainable path to achieving its boldest aspirations in space. Photo Credit: (NASA/Bill Ingalls)

Human Space Flight Plans Committee Report

NASA Image and Video Library

2009-10-21

Chairman of the U.S. Human Space Flight Plans Committee Norman Augustine answers a reporters question during a press conference where the committee released it's report on Thursday, Oct., 22, 2009 at the National Press Club in Washington. The Obama Administration tasked the committee to do an independent review of planned U.S. human space flight activities with the goal of ensuring that the nation is on a vigorous and sustainable path to achieving its boldest aspirations in space. Photo Credit: (NASA/Bill Ingalls)

Novel chronotherapeutic rectal aminophylline delivery system for therapy of asthma.

PubMed

Shiohira, Hideo; Fujii, Makiko; Koizumi, Naoya; Kondoh, Masuo; Watanabe, Yoshiteru

2009-09-08

The aim of this study was to develop a new chronotherapeutic pharmaceutical preparation as a sustained-release suppository for prevention and therapeutic use against bronchial asthma in the early morning. Sustained-release hollow-type (SR-HT) suppositories using sodium alginate (Alg-Na), sodium polyacrylate (PANa) or polyacrylate-PANa co-polymer (PA-PANa) as gelling polymers (gel agent) were prepared and pharmaceutical characteristics of these suppositories were investigated. Type A SR-HT suppositories comprised a suppository shell prepared with oleaginous base and containing aminophylline only or aminophylline with Alg-Na or PANa in the cavity (hollow space). Type B SR-HT suppositories comprised a suppository shell prepared with oleaginous base and gel agent (30%), with aminophylline in the hollow space. In drug-release studies, the acrylate polymer-containing suppositories showed linearity of delayed release rate, providing significantly decreased the highest concentration of theophylline in plasma (C(max)) and delayed the time required to reach C(max) (t(max)) and the mean residence time (MRT) after rectal administrated in rabbits. In particular, suppositories containing PA-PANa maintained significantly higher theophylline concentrations than control suppositories at 12h after rectal administration. Furthermore, histopathological examination indicated that these suppositories using acrylate polymers did not result in rectal lesions. The SR-HT suppository, particularly using PA-PANa as a gel agent, may thus be useful against nocturnal symptoms of asthma. In this study, we confirmed new formulation of sustained-release suppository for chronotherapy of theophylline using oily base material in combination with polymer such as PA-PANa. The hollow-type suppository containing oleaginous base and hydrophilic polymer in the shell could be useful device for rectal administration of various drugs with prolongation of plasma concentration.

The WCRP/GEWEX Surface Radiation Budget Project Release 2: An Assessment of Surface Fluxes at 1 Degree Resolution

NASA Technical Reports Server (NTRS)

Stackhouse, P. W., Jr.; Gupta, S. K.; Cox, S. J.; Chiacchio, M.; Mikovitz, J. C.

2004-01-01

The U.S. National Aeronautics and Space Administration (NASA) based Surface Radiation Budget (SRB) Project in association with the World Climate Research Programme Global Energy and Water Cycle Experiment (WCRP/GEWEX) is preparing a new 1 deg x 1 deg horizontal resolution product for distribution scheduled for release in early 2001. The new release contains several significant upgrades from the previous version. This paper summarizes the most significant upgrades and presents validation results as an assessment of the new data set.

Human Space Flight Plans Committee Report

NASA Image and Video Library

2009-10-21

NASA Public Affairs Officer Doc Mirelson, left, and Chairman of the U.S. Human Space Flight Plans Committee Norman Augustine, right, listen to reporters questions during a press conference where the committee released it's report on Thursday, Oct., 22, 2009 at the National Press Club in Washington. The Obama Administration tasked the committee to do an independent review of planned U.S. human space flight activities with the goal of ensuring that the nation is on a vigorous and sustainable path to achieving its boldest aspirations in space. Photo Credit: (NASA/Bill Ingalls)

Human Space Flight Plans Committee Report

NASA Image and Video Library

2009-10-21

Copies of the U.S. Human Space Flight Plans Committee report are seen in the foreground of Chairman of the U.S. Human Space Flight Plans Committee Norman Augustine, left, and committee member Ed Crawley, right, during a press conference where the committee released it's report on Thursday, Oct., 22, 2009 at the National Press Club in Washington. The Obama Administration tasked the committee to do an independent review of planned U.S. human space flight activities with the goal of ensuring that the nation is on a vigorous and sustainable path to achieving its boldest aspirations in space. Photo Credit: (NASA/Bill Ingalls)

14 CFR 125.375 - Fuel supply: Nonturbine and turbopropeller-powered airplanes.

Code of Federal Regulations, 2014 CFR

2014-01-01

...-powered airplanes. 125.375 Section 125.375 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... AND OPERATIONS CERTIFICATION AND OPERATIONS: AIRPLANES HAVING A SEATING CAPACITY OF 20 OR MORE... AIRCRAFT Flight Release Rules § 125.375 Fuel supply: Nonturbine and turbopropeller-powered airplanes. (a...

14 CFR 125.375 - Fuel supply: Nonturbine and turbopropeller-powered airplanes.

Code of Federal Regulations, 2012 CFR

2012-01-01

...-powered airplanes. 125.375 Section 125.375 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... AND OPERATIONS CERTIFICATION AND OPERATIONS: AIRPLANES HAVING A SEATING CAPACITY OF 20 OR MORE... AIRCRAFT Flight Release Rules § 125.375 Fuel supply: Nonturbine and turbopropeller-powered airplanes. (a...

14 CFR 125.375 - Fuel supply: Nonturbine and turbopropeller-powered airplanes.

Code of Federal Regulations, 2013 CFR

2013-01-01

...-powered airplanes. 125.375 Section 125.375 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... AND OPERATIONS CERTIFICATION AND OPERATIONS: AIRPLANES HAVING A SEATING CAPACITY OF 20 OR MORE... AIRCRAFT Flight Release Rules § 125.375 Fuel supply: Nonturbine and turbopropeller-powered airplanes. (a...

14 CFR 125.375 - Fuel supply: Nonturbine and turbopropeller-powered airplanes.

Code of Federal Regulations, 2011 CFR

2011-01-01

...-powered airplanes. 125.375 Section 125.375 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... AND OPERATIONS CERTIFICATION AND OPERATIONS: AIRPLANES HAVING A SEATING CAPACITY OF 20 OR MORE... AIRCRAFT Flight Release Rules § 125.375 Fuel supply: Nonturbine and turbopropeller-powered airplanes. (a...

14 CFR 125.375 - Fuel supply: Nonturbine and turbopropeller-powered airplanes.

Code of Federal Regulations, 2010 CFR

2010-01-01

...-powered airplanes. 125.375 Section 125.375 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... AND OPERATIONS CERTIFICATION AND OPERATIONS: AIRPLANES HAVING A SEATING CAPACITY OF 20 OR MORE... AIRCRAFT Flight Release Rules § 125.375 Fuel supply: Nonturbine and turbopropeller-powered airplanes. (a...

International Space Station Science Research Accomplishments During the Assembly Years: An Analysis of Results from 2000-2008

NASA Technical Reports Server (NTRS)

Evans, Cynthia A.; Robinson, Julie A.; Tate-Brown, Judy; Thumm, Tracy; Crespo-Richey, Jessica; Baumann, David; Rhatigan, Jennifer

2009-01-01

This report summarizes research accomplishments on the International Space Station (ISS) through the first 15 Expeditions. When research programs for early Expeditions were established, five administrative organizations were executing research on ISS: bioastronautics research, fundamental space biology, physical science, space product development, and space flight. The Vision for Space Exploration led to changes in NASA's administrative structures, so we have grouped experiments topically by scientific themes human research for exploration, physical and biological sciences, technology development, observing the Earth, and educating and inspiring the next generation even when these do not correspond to the administrative structure at the time at which they were completed. The research organizations at the time at which the experiments flew are preserved in the appendix of this document. These investigations on the ISS have laid the groundwork for research planning for Expeditions to come. Humans performing scientific investigations on ISS serve as a model for the goals of future Exploration missions. The success of a wide variety of investigations is an important hallmark of early research on ISS. Of the investigations summarized here, some are completed with results released, some are completed with preliminary results, and some remain ongoing.

14 CFR 91.309 - Towing: Gliders and unpowered ultralight vehicles.

Code of Federal Regulations, 2010 CFR

2010-01-01

... vehicle have agreed upon a general course of action, including takeoff and release signals, airspeeds, and... vehicles. 91.309 Section 91.309 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES GENERAL OPERATING AND FLIGHT RULES Special...

14 CFR 121.657 - Flight altitude rules.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Flight altitude rules. 121.657 Section 121... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Dispatching and Flight Release Rules § 121.657 Flight... other flight conditions, the Administrator prescribes other minimums for any route or part of a route...

14 CFR 121.657 - Flight altitude rules.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Flight altitude rules. 121.657 Section 121... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Dispatching and Flight Release Rules § 121.657 Flight... other flight conditions, the Administrator prescribes other minimums for any route or part of a route...

14 CFR 121.657 - Flight altitude rules.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Flight altitude rules. 121.657 Section 121... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Dispatching and Flight Release Rules § 121.657 Flight... other flight conditions, the Administrator prescribes other minimums for any route or part of a route...

14 CFR 121.657 - Flight altitude rules.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Flight altitude rules. 121.657 Section 121... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Dispatching and Flight Release Rules § 121.657 Flight... other flight conditions, the Administrator prescribes other minimums for any route or part of a route...

Sustained reduction of intraocular pressure by supraciliary delivery of brimonidine-loaded poly(lactic acid) microspheres for the treatment of glaucoma

PubMed Central

Chiang, B.; Kim, Y.C.; Doty, A.C.; Grossniklaus, H.E.; Schwendeman, S.P.; Prausnitz, M.R.

2016-01-01

Although effective drugs that lower intraocular pressure (IOP) in the management of glaucoma exist, their efficacy is limited by poor patient adherence to the prescribed eye drop regimen. To replace the need for eye drops, in this study we tested the hypothesis that IOP can be reduced for one month after a single targeted injection using a microneedle for administration of a glaucoma medication (i.e., brimonidine) formulated for sustained release in the supraciliary space of the eye adjacent to the drug’s site of action at the ciliary body. To test this hypothesis, brimonidine-loaded microspheres were formulated using poly(lactic acid) (PLA) to release brimonidine at a constant rate for 35 days and microneedles were designed to penetrate through the sclera, without penetrating into the choroid/retina, in order to target injection into the supraciliary space. A single administration of these microspheres using a hollow microneedle was performed in the eye of New Zealand White rabbits and was found to reduce IOP initially by 6 mm Hg and then by progressively smaller amounts for more than one month. All administrations were well tolerated without significant adverse events, although histological examination showed a foreign-body reaction to the microspheres. This study demonstrates, for the first time, that the highly-targeted delivery of brimonidine-loaded microspheres into the supraciliary space using a microneedle is able to reduce IOP for one month as an alternative to daily eye drops. PMID:26930266

78 FR 27472 - Agency Information Collection Activities: Requests for Comments; Clearance of New Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-10

... Display to Industry (ASDI) Block Requests AGENCY: Federal Aviation Administration (FAA), DOT. ACTION... information will be used by the National Air Space Data Release Office to block aircraft flight data as... Display to Industry (ASDI) Block Requests. Form Numbers: There are no FAA forms associated with this...

Canadian Environmental Concerns: Winnipeg, Manitoba. Progress Report. Project Canada West.

ERIC Educational Resources Information Center

Western Curriculum Project on Canada Studies, Edmonton (Alberta).

Part I of this progress report places emphasis on curriculum development from the standpoint of the teacher-developer. The role is defined and factors such as teacher selection, release time, administrative cooperation, work schedules, assigned work space, and benefits to the school division and to the teacher are discussed. Recommendations deal…

Chlorofluoromethanes and the Stratosphere

NASA Technical Reports Server (NTRS)

Hudson, R. D. (Editor)

1977-01-01

The conclusions of a workshop held by the National Aeronautics and Space Administration to assess the current knowledge of the impact of chlorofluoromethane release in the troposphere on stratospheric ozone concentrations. The following topics are discussed; (1) Laboratory measurements; (2) Ozone measurements and trends; (3) Minor species and aerosol measurements; (4) One dimensional modeling; and (5) Multidimensional modeling.

Pharmacodynamic evaluation of clopidogrel plus PA32540: the Spaced PA32540 With Clopidogrel Interaction Gauging (SPACING) study.

PubMed

Gurbel, P A; Bliden, K P; Fort, J; Zhang, Y; Plachetka, J R; Antonino, M; Gesheff, M; Tantry, U S

2011-12-01

PA32540 combines 325 mg enteric-coated (EC) aspirin (ASA) with 40 mg immediate-release omeprazole; its influence on the antiplatelet effect of clopidogrel (C) is unknown. In this randomized, open-label study, subjects (n = 30) were treated with (i) 300 mg C + 325 mg ECASA followed by 75 mg C + 325 mg ECASA on days 2-7, (ii) 300 mg C + PA32540 followed by 75 mg C + PA32540 on days 2-7, or (iii) PA32540 in the morning + 300 mg C 10 h later on day 1 and PA32540 in the morning + 75 mg C 10 h later on days 2-7. We analyzed the noninferiority of PA32540 relative to ECASA, as defined by the upper bound of the 95% confidence interval ≤10% for the difference in least-square means of platelet inhibition between the treatments. As compared to ECASA+C, synchronous treatment of PA32540+C was not noninferior, whereas the spacing strategy of PA32540+C was noninferior. Spacing the administration of PA32540 and clopidogrel lessens the interaction observed with synchronous administration; PA32540 administration with clopidogrel may be associated with a different antiplatelet profile.

The Vision for Space Exploration

NASA Technical Reports Server (NTRS)

2004-01-01

With last year's budget, NASA released a new Strategic Plan outlining a new approach to space exploration using a 'building block' strategy to explore scientifically valuable destinations across our solar system. At the same time that we released the Strategic Plan, our Nation and the NASA family also suffered the loss of the seven brave astronauts aboard the Space Shuttle Columbia. The report of the Columbia Accident Investigation Board emphasized the need for a clearer direction from which to drive NASA's human exploration agenda. On January 14, 2004, the President articulated a new vision for space exploration. You hold in your hands a new, bolder framework for exploring our solar system that builds upon the policy that was announced by the President after months of careful deliberations within the Administration. This plan does not undertake exploration merely for the sake of adventure, however exciting that may be, but seeks answers to profound scientific and philosophical questions, responds to recent discoveries, will put in place revolutionary technologies and capabilities for the future, and will genuinely inspire our Nation, the world, and the next generation. Our aim is to explore in a sustainable, affordable, and flexible manner. We believe the principles and roadmap set down in this document will stand the test of time. Its details will be subject to revision and expansion as new discoveries are made, new technologies are applied, and new challenges are met and overcome. This plan is guided by the Administration's new space exploration policy, 'A Renewed Spirit of Discovery: The President's Vision for U.S. Space Exploration,' a copy of which is provided on the following pages. NASA is releasing this plan simultaneously with NASA's FY 2005 Budget Justification. This plan is fiscally responsible, consistent with the Administration s goal of cutting the budget deficit in half within the next five years. I cannot overstate how much NASA will change in the coming years as this plan is implemented. I also cannot overstate how profound the rewards will be on this new course. With the support of Congress, the science community, the NASA civil and contractor workforce, and most importantly, the American public, we will embark on this very exciting future. When Christopher Columbus made his voyages across the Atlantic in the 15th and 16th centuries, his ships carried the inscription 'Following the light of the sun, we left the Old World.' I look forward to joining you as we follow the light of the planets and the stars into the new worlds of the 21st century.

Counter Tunnel Project

DTIC Science & Technology

2014-03-01

ADMINISTRATIVE INFORMATION The work described in this report was performed by the Unmanned Systems Science & Technology Branch (Code 71710) and the...Unmanned Systems Advanced Development Branch (Code 71720), Space and Naval Warfare Systems Center Pacific (SSC Pacific), San Diego, CA, and the Air...Earth™ is a trademark of Google Inc. Released by T. Pastore, Head Unmanned Systems Science & Technology Branch Under authority of A. D

Telecommuting and health care: a potential for cost reductions and productivity gains.

PubMed

Jacobs, S M; Pelfrey, S; Van Sell, M

1995-12-01

Health care administrators are striving to maintain positive operating margins while remaining responsive to community needs. As they look for ways to reduce costs and improve productivity, they may consider the benefits associated with telecommuting. Telecommuting refers to the work performed by organizational employees who use computers and telecommunication equipment to work at home or at remote sites one or more days a week. Benefits to the health care industry include release of valuable hospital space, reduced employee turnover, and increased productivity. The time away from the institution may provide administrators with valuable planning time, free from interruptions.

Dissolution kinetics of iron-, manganese-, and copper-containing synthetic hydroxyapatites

NASA Technical Reports Server (NTRS)

Sutter, B.; Hossner, L. R.; Ming, D. W.

2005-01-01

Micronutrient-substituted synthetic hydroxyapatite (SHA) is being evaluated by the National Aeronautics and Space Administration's (NASA) Advanced Life Support (ALS) Program for crop production on long-duration human missions to the International Space Station or for future Lunar or Martian outposts. The stirred-flow technique was utilized to characterize Ca, P, Fe, Mn, and Cu release characteristics from Fe-, Mn-, and Cu-containing SHA in deionized (DI) water, citric acid, and diethylene-triamine-pentaacetic acid (DTPA). Initially, Ca and P release rates decreased rapidly with time and were controlled by a non-SHA calcium phosphate phase(s) with low Ca/P solution molar ratios (0.91-1.51) relative to solid SHA ratios (1.56-1.64). At later times, Ca/P solution molar ratios (1.47-1.79) were near solid SHA ratios and release rates decreased slowly indicating that SHA controlled Ca and P release. Substituted SHA materials had faster dissolution rates relative to unsubstituted SHA. The initial metal release rate order was Mn >> Cu > Fe which followed metal-oxide/phosphate solubility suggesting that poorly crystalline metal-oxides/phosphates were dominating metal release. Similar metal release rates for all substituted SHA (approximately 0.01 cmol kg-1 min-1) at the end of the DTPA experiment indicated that SHA dissolution was supplying the metals into solution and that poorly crystalline metal-oxide/phosphates were not controlling metal release. Results indicate that non-SHA Ca-phosphate phases and poorly crystalline metal-oxide/phosphates will contribute Ca, P, and metals. After these phases have dissolved, substituted SHA will be the source of Ca, P, and metals for plants.

Venture Capital and Strategic Investment for Developing Government Mission Capabilities

DTIC Science & Technology

2014-01-01

JIEDDO Joint Improvised Explosive Device Defeat Organization NASA National Aeronautics and Space Administration NGA National Geospatial-Intelligence... USDA Investments at Risk Due to Corporation’s Mismanagement, U.S. Department of Agriculture press release, December 2, 1999. 16 V en tu re C ap...2000 agriculture Independent within USDa Limited terminated for lack of effective internal control structure, limited effectiveness In-Q-tel 1999

KSC-2010-5447

NASA Image and Video Library

2010-11-03

CAPE CANAVERAL, Fla. -- On the NASA Causeway at Kennedy Space Center in Florida, Leland Melvin, NASA's associate administrator for Education, center, and Stephan Turnipseed, president of LEGO Education North America, right, help a student build LEGO space vehicles inside a 40- by 70-foot activity tent. There, children of all ages are building their vision of the future with LEGO bricks, marking the beginning of a three-year Space Act Agreement meant to spark the interest of children in science, technology, engineering and mathematics (STEM). To commemorate the partnership, two small LEGO space shuttles will launch aboard space shuttle Discovery's STS-133 mission to the International Space Station and the company will release four NASA-inspired products in its LEGO CITY line next year. LEGO sets also will fly to the space station aboard Endeavour's STS-134 mission, and will be put together on orbit to demonstrate the challenges faced while building things in microgravity. Photo credit: NASA/Jack Pfaller

Astronaut Susan Helms on aft flight deck with RMS controls

NASA Image and Video Library

1994-09-12

STS064-05-028 (9-20 Sept. 1994) --- On the space shuttle Discovery's aft flight deck, astronaut Susan J. Helms handles controls for the Remote Manipulator System (RMS). The robot arm operated by Helms, who remained inside the cabin, was used to support several tasks performed by the crew during the almost 11-day mission. Those tasks included the release and retrieval of the free-flying Shuttle Pointed Autonomous Research Tool For Astronomy 201 (SPARTAN 201), a six-hour spacewalk and the Shuttle Plume Impingement Flight Experiment (SPIFEX). Photo credit: NASA or National Aeronautics and Space Administration

Zeoponic Plant Growth Substrate Development at the Johnson Space Center and Possible Use at a Martian Outpost

NASA Technical Reports Server (NTRS)

Gruener, John E.; Ming, Douglas W.

2000-01-01

The National Aeronautics and Space Administration (NASA) Johnson Space Center (JSC) is developing a substrate, termed zeoponics, that will slowly release all of the essential nutrients into solution for plant growth experiments in advanced life support system testbeds. This substrate is also potentially useful in the near future on the Space Shuttle and International Space Station and could eventually be used at an outpost on Mars. Chemical analyses of the Martian soil by the Viking and Mars Pathfinder missions have indicated that several of the elements required for plant growth are available in the soil. It may be possible to use the martian soil as the bulk substrate for growing food crops, while using smaller amounts of zeoponic substrate as an amendment to rectify any nutrient deficiencies.

Spaced administration of PA32540 and clopidogrel results in greater platelet inhibition than synchronous administration of enteric-coated aspirin and enteric-coated omeprazole and clopidogrel.

PubMed

Gurbel, Paul A; Bliden, Kevin P; Fort, John G; Jeong, Young-Hoon; Shuldiner, Alan; Chai, Sumbul; Gesheff, Tania; Antonino, Mark; Gesheff, Martin; Zhang, Ying; Tantry, Udaya S

2013-02-01

A common regimen for patients requiring dual-antiplatelet therapy who are at risk for gastrointestinal complications is the synchronous administration of enteric-coated (EC) aspirin, a proton pump inhibitor, and clopidogrel, although proton pump inhibitors have the potential for pharmacodynamic interaction with clopidogrel. Spaced administration of a clopidogrel and a single-tablet formulation of aspirin and immediate-release omeprazole (PA32540) was considered as an alternative that might reduce this potential pharmacodynamic interaction. A randomized, open-label, crossover study was conducted in healthy subjects (n = 30). Two 7-day treatments were separated by 14-day washout periods: (a) PA32540 + clopidogrel (300 mg loading/75 mg maintenance) 10 hours later and (b) synchronous dosing of clopidogrel + EC aspirin (81 mg) + EC omeprazole (40 mg). The primary end point was the inhibition of platelet aggregation (20 μM adenosine diphosphate, maximal extent) after 7 days. CYP2C19 and ABCB1 genotypes were determined. Inhibition of platelet aggregation was greater with spaced PA32540 + clopidogrel therapy vs synchronous clopidogrel + EC aspirin + EC omeprazole therapy (P = .004). There was no difference in day 7 arachidonic acid-induced aggregation. The effect of spacing on pharmacodynamics was independent of genotype. PA32540 and clopidogrel spaced 10 hours apart had greater antiplatelet effects than did synchronously administered EC aspirin (81 mg), clopidogrel (75 mg), and EC omeprazole in healthy volunteers. These finding are directly relevant to the treatment for patients with high gastrointestinal risk who require dual-antiplatelet therapy and gastroprotection. Copyright © 2013 Mosby, Inc. All rights reserved.

KSC-2010-5441

NASA Image and Video Library

2010-11-03

CAPE CANAVERAL, Fla. -- Stephan Turnipseed, president of LEGO Education North America, left, a space person, and Leland Melvin, NASA's associate administrator for Education, show off toy space people inside a 40- by 70-foot activity tent chock full of LEGO bricks on the NASA Causeway at Kennedy Space Center in Florida. There, children of all ages are building their vision of the future with LEGO bricks, marking the beginning of a three-year Space Act Agreement meant to spark the interest of children in science, technology, engineering and mathematics (STEM). To commemorate the partnership, two small LEGO space shuttles will launch aboard space shuttle Discovery's STS-133 mission to the International Space Station and the company will release four NASA-inspired products in its LEGO CITY line next year. LEGO sets also will fly to the space station aboard Endeavour's STS-134 mission, and will be put together on orbit to demonstrate the challenges faced while building things in microgravity. Photo credit: NASA/Jack Pfaller

ourney to Mars: An international effort on This Week @NASA – October 16, 2015

NASA Image and Video Library

2015-10-16

During meetings and public events at the International Astronautical Congress (IAC), Oct. 12-16 in Jerusalem, NASA Administrator Charlie Bolden and several other NASA officials highlighted the agency’s recently released plan to send astronauts to Mars in the 2030’s. They also emphasized the need for international partnerships and cooperation to make a mission of this magnitude a reality, the importance of harnessing enthusiasm for space exploration and the need to encourage young people to develop the skills we’ll need for the Journey to Mars. Also, New American record in space, Flyby of Saturnian moon, Next launch for Cygnus, Access to space for small satellites and more! JPL Open House is a big draw.

28 CFR 513.20 - Release of information to law enforcement agencies.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Release of information to law enforcement agencies. 513.20 Section 513.20 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE GENERAL MANAGEMENT AND ADMINISTRATION ACCESS TO RECORDS Release of Information to Law Enforcement Agencies § 513.20 Release of information to law...

KSC-2010-5418

NASA Image and Video Library

2010-11-02

CAPE CANAVERAL, Fla. -- NASA and The LEGO Group announce a three-year Space Act Agreement meant to spark the interest of children in science, technology, engineering and mathematics (STEM) with the future release of four NASA-inspired products in the toy company's LEGO CITY line. From left, are Stephan Turnipseed, president of LEGO Education North America, and Leland Melvin, NASA's associate administrator for Education. To commemorate the beginning of the partnership, two small LEGO space shuttles will launch aboard space shuttle Discovery's STS-133 mission to the International Space Station. A 40- by 70-foot activity tent will be set up at Kennedy on Nov. 3 for children of all ages to build their vision of the future with LEGO bricks. LEGO sets also will fly to the space station aboard Endeavour's STS-134 mission, and will be put together on orbit to demonstrate the challenges faced while building things in microgravity. Photo credit: NASA/Jack Pfaller

KSC-2010-5421

NASA Image and Video Library

2010-11-02

CAPE CANAVERAL, Fla. -- NASA and The LEGO Group announce a three-year Space Act Agreement meant to spark the interest of children in science, technology, engineering and mathematics (STEM) with the future release of four NASA-inspired products in the toy company's LEGO CITY line. From left, are Stephan Turnipseed, president of LEGO Education North America, and Leland Melvin, NASA's associate administrator for Education. To commemorate the beginning of the partnership, two small LEGO space shuttles will launch aboard space shuttle Discovery's STS-133 mission to the International Space Station. A 40- by 70-foot activity tent will be set up at Kennedy on Nov. 3 for children of all ages to build their vision of the future with LEGO bricks. LEGO sets also will fly to the space station aboard Endeavour's STS-134 mission, and will be put together on orbit to demonstrate the challenges faced while building things in microgravity. Photo credit: NASA/Jack Pfaller

KSC-2010-5417

NASA Image and Video Library

2010-11-02

CAPE CANAVERAL, Fla. -- NASA and The LEGO Group announce a three-year Space Act Agreement meant to spark the interest of children in science, technology, engineering and mathematics (STEM) with the future release of four NASA-inspired products in the toy company's LEGO CITY line. From left, are Stephan Turnipseed, president of LEGO Education North America, and Leland Melvin, NASA's associate administrator for Education. To commemorate the beginning of the partnership, two small LEGO space shuttles will launch aboard space shuttle Discovery's STS-133 mission to the International Space Station. A 40- by 70-foot activity tent will be set up at Kennedy on Nov. 3 for children of all ages to build their vision of the future with LEGO bricks. LEGO sets also will fly to the space station aboard Endeavour's STS-134 mission, and will be put together on orbit to demonstrate the challenges faced while building things in microgravity. Photo credit: NASA/Jack Pfaller

Astronaut Carl Meade mans pilots station during trajectory control exercise

NASA Image and Video Library

1994-09-12

STS064-22-024 (9-20 Sept. 1994) --- With a manual and lap top computer in front of him, astronaut Carl J. Meade, STS-64 mission specialist, supports operations with the Trajectory Control Sensor (TCS) aboard the Earth-orbiting space shuttle Discovery. For this exercise, Meade temporarily mans the pilot's station on the forward flight deck. The TCS is the work of a team of workers at NASA's Johnson Space Center. Data gathered during this flight was expected to prove valuable in designing and developing a sensor for use during the rendezvous and mating phases of orbiter missions to the space station. For this demonstration, the Shuttle Pointed Autonomous Research Tool for Astronomy 201 (SPARTAN 201) was used as the target vehicle during release and retrieval operations. Photo credit: NASA or National Aeronautics and Space Administration

KSC-2010-5439

NASA Image and Video Library

2010-11-03

CAPE CANAVERAL, Fla. -- Stephan Turnipseed, president of LEGO Education North America, left, and Leland Melvin, NASA's associate administrator for Education, discuss the new partnership between the U.S. space agency and the toy company inside a 40- by 70-foot activity tent chock full of LEGO bricks on the NASA Causeway at Kennedy Space Center in Florida. There, children of all ages are building their vision of the future with LEGO bricks, marking the beginning of a three-year Space Act Agreement meant to spark the interest of children in science, technology, engineering and mathematics (STEM). To commemorate the partnership, two small LEGO space shuttles will launch aboard space shuttle Discovery's STS-133 mission to the International Space Station and the company will release four NASA-inspired products in its LEGO CITY line next year. LEGO sets also will fly to the space station aboard Endeavour's STS-134 mission, and will be put together on orbit to demonstrate the challenges faced while building things in microgravity. Photo credit: NASA/Jack Pfaller

28 CFR 8.6 - Quick-release authority.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Quick-release authority. 8.6 Section 8.6 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.6 Quick-release authority. Where the forfeiture proceedings are administrative, the Special Agent in Charge, prior...

28 CFR 8.6 - Quick-release authority.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Quick-release authority. 8.6 Section 8.6 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.6 Quick-release authority. Where the forfeiture proceedings are administrative, the Special Agent in Charge, prior...

KSC-2010-5419

NASA Image and Video Library

2010-11-02

CAPE CANAVERAL, Fla. -- NASA and The LEGO Group announce a three-year Space Act Agreement meant to spark the interest of children in science, technology, engineering and mathematics (STEM) with the future release of four NASA-inspired products in the toy company's LEGO CITY line. From left, are Debbie Biggs, education specialist for International Space Station National Lab Education Projects, Stephan Turnipseed, president of LEGO Education North America, and Leland Melvin, NASA's associate administrator for Education. To commemorate the beginning of the partnership, two small LEGO space shuttles will launch aboard space shuttle Discovery's STS-133 mission to the International Space Station. A 40- by 70-foot activity tent will be set up at Kennedy on Nov. 3 for children of all ages to build their vision of the future with LEGO bricks. LEGO sets also will fly to the space station aboard Endeavour's STS-134 mission, and will be put together on orbit to demonstrate the challenges faced while building things in microgravity. Photo credit: NASA/Jack Pfaller

KSC-2010-5420

NASA Image and Video Library

2010-11-02

CAPE CANAVERAL, Fla. -- NASA and The LEGO Group announce a three-year Space Act Agreement meant to spark the interest of children in science, technology, engineering and mathematics (STEM) with the future release of four NASA-inspired products in the toy company's LEGO CITY line. From left, are Debbie Biggs, education specialist for International Space Station National Lab Education Projects, Stephan Turnipseed, president of LEGO Education North America, and Leland Melvin, NASA's associate administrator for Education. To commemorate the beginning of the partnership, two small LEGO space shuttles will launch aboard space shuttle Discovery's STS-133 mission to the International Space Station. A 40- by 70-foot activity tent will be set up at Kennedy on Nov. 3 for children of all ages to build their vision of the future with LEGO bricks. LEGO sets also will fly to the space station aboard Endeavour's STS-134 mission, and will be put together on orbit to demonstrate the challenges faced while building things in microgravity. Photo credit: NASA/Jack Pfaller

KSC-2010-5415

NASA Image and Video Library

2010-11-02

CAPE CANAVERAL, Fla. -- NASA and The LEGO Group announce a three-year Space Act Agreement meant to spark the interest of children in science, technology, engineering and mathematics (STEM) with the future release of four NASA-inspired products in the toy company's LEGO CITY line. From left, are Debbie Biggs, education specialist for International Space Station National Lab Education Projects, Stephan Turnipseed, president of LEGO Education North America, Leland Melvin, NASA's associate administrator for Education, and Ann Marie Trotta, NASA Public Affairs officer. To commemorate the beginning of the partnership, two small LEGO space shuttles will launch aboard space shuttle Discovery's STS-133 mission to the International Space Station. A 40- by 70-foot activity tent will be set up at Kennedy on Nov. 3 for children of all ages to build their vision of the future with LEGO bricks. LEGO sets also will fly to the space station aboard Endeavour's STS-134 mission, and will be put together on orbit to demonstrate the challenges faced while building things in microgravity. Photo credit: NASA/Jack Pfaller

KSC-2010-5416

NASA Image and Video Library

2010-11-02

CAPE CANAVERAL, Fla. -- NASA and The LEGO Group announce a three-year Space Act Agreement meant to spark the interest of children in science, technology, engineering and mathematics (STEM) with the future release of four NASA-inspired products in the toy company's LEGO CITY line. From left, are Debbie Biggs, education specialist for International Space Station National Lab Education Projects, Stephan Turnipseed, president of LEGO Education North America, and Leland Melvin, NASA's associate administrator for Education. To commemorate the beginning of the partnership, two small LEGO space shuttles will launch aboard space shuttle Discovery's STS-133 mission to the International Space Station. A 40- by 70-foot activity tent will be set up at Kennedy on Nov. 3 for children of all ages to build their vision of the future with LEGO bricks. LEGO sets also will fly to the space station aboard Endeavour's STS-134 mission, and will be put together on orbit to demonstrate the challenges faced while building things in microgravity. Photo credit: NASA/Jack Pfaller

Explanatory Supplement to the WISE All-Sky Release Products

NASA Technical Reports Server (NTRS)

2012-01-01

The Wide-field Infrared Survey Explorer (WISE; Wright et al. 2010) surveyed the entire sky at 3.4, 4.6, 12 and 22 microns in 2010, achieving 5-sigma point source sensitivities per band better than 0.08, 0.11, 1 and 6 mJy in unconfused regions on the ecliptic. The WISE All-Sky Data Release, conducted on March 14, 2012, incorporates all data taken during the full cryogenic mission phase, 7 January 2010 to 6 August 20l0,that were processed with improved calibrations and reduction algorithms. Release data products include: (1) an Atlas of 18,240 match-filtered, calibrated and coadded image sets; (2) a Source Catalog containing positions and four-band photometry for over 563 million objects, and (3) an Explanatory Supplement. Ancillary products include a Reject Table that contains 284 million detections that were not selected for the Source Catalog because they are low signal-to-noise ratio or spurious detections of image artifacts, an archive of over 1.5 million sets of calibrated WISE Single-exposure images, and a database of 9.4 billion source extractions from those single images, and moving object tracklets identified by the NEOWISE program (Mainzer et aI. 2011). The WISE All-Sky Data Release products supersede those from the WISE Preliminary Data Release (Cutri et al. 2011). The Explanatory Supplement to the WISE All-Sky Data Release Products is a general guide for users of the WISE data. The Supplement contains an overview of the WISE mission, facilities, and operations, a detailed description of WISE data processing algorithms, a guide to the content and formals of the image and tabular data products, and cautionary notes that describe known limitations of the All-Sky Release products. Instructions for accessing the WISE data products via the services of the NASA/IPAC Infrared Science Archive are provided. The Supplement also provides analyses of the achieved sky coverage, photometric and astrometric characteristics and completeness and reliability of the All-Sky Release data products. The WISE All-Sky Release Explanatory Supplement is an on-line document that is updated frequently to provide the most current information for users of the WISE data products. The Explanatory Supplement is maintained at: http://wise2.ipac.caltech.edu/docs/release/allsky/expsup/index.html WISE is a joint project of the University of California, Los Angeles and the Jet Propulsion Laboratory/California Institute of Technology, funded by the National Aeronautics and Space Administration. NEOWISE is a project of the Jet Propulsion Laboratory/California Institute of Technology, funded by the Planetary Science Division of the National Aeronautics and Space Administration.

34th Aerospace Mechanisms Symposium

NASA Technical Reports Server (NTRS)

Boesiger, Edward A. (Compiler)

2000-01-01

The Aerospace Mechanisms Symposium (AMS) provides a unique forum for those active in the design, production and use of aerospace mechanisms. A major focus is the reporting of problems and solutions associated with the development and flight certification of new mechanisms. The National Aeronautics and Space Administration and Lockheed Martin Space Systems Company (LMSSC) share the responsibility for organizing the AMS. Now in its 34th year, the AMS continues to be well attended, attracting participants from both the U.S. and abroad. The 34th AMS, hosted by the Goddard Space Flight Center (GSFC) in Greenbelt, Maryland, was held May 10, 11 and 12, 2000. During these three days, 34 papers were presented. Topics included deployment mechanisms, bearings, actuators, pointing and optical mechanisms, Space Station mechanisms, release mechanisms, and test equipment. Hardware displays during the vendor fair gave attendees an opportunity to meet with developers of current and future mechanism components.

Examination of meningocele induced by the antitumor agent DE-310 in rat fetuses.

PubMed

Kato, Michiyuki; Matsuhashi, Kunio; Shimomura, Kazuhiro; Shimada, Makoto; Hagiwara, Miyoko; Fujikawa, Katsuko; Furuhama, Kazuhisa

2005-01-01

The antitumor drug, DE-310, is the slow release form of the camptothecin derivative DX-8951. We investigated a toxicological profile of meningoceles in SD rat fetuses, whose mothers received intravenous DE-310 at several doses, and the time course changes of histology. DE-310 induced a meningocele in the posterior fontanelle of live fetuses by the four-time administration of 0.3 mg/(kgday) or more during the organogenetic period, or by a single administration of 1.0 mg/kg, particularly, between days 7 and 13 of gestation with an incidence of 100%. The meningocele was caused by the principal ingredient DX-8951. The earliest histological change was focal congestion between the skin and cerebrum, followed by the formation of a space covered by thinned epidermis with necrosed basal cells, hemorrhage in the surrounding connective tissues, cerebrum and ventricles, cavitation of the cerebrum, and incomplete formation of the skull bones and subarachnoid space. DE-310 was characterized as preferentially inducing meningocele (meningoencephalocele in severe cases) in rat fetuses.

28 CFR 8.6 - Quick-release authority.

Code of Federal Regulations, 2010 CFR

2010-07-01

...-release authority. Where the forfeiture proceedings are administrative, the Special Agent in Charge, prior to forfeiture, is authorized to release property seized for forfeiture. The property can be quick... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Quick-release authority. 8.6 Section 8.6...

50 CFR 600.425 - Release of statistics.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Release of statistics. 600.425 Section... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Confidentiality of Statistics § 600.425 Release of statistics. (a) The Assistant Administrator will not release to the public any statistics...

50 CFR 600.425 - Release of statistics.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Release of statistics. 600.425 Section 600... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Confidentiality of Statistics § 600.425 Release of statistics. (a) The Assistant Administrator will not release to the public any statistics...

National Aeronautics and Space Administration (nasa)/american Society for Engineering Education (ASEE) Summer Faculty Fellowship Program, 1991, Volume 1

NASA Technical Reports Server (NTRS)

Hyman, William A. (Editor); Goldstein, Stanley H. (Editor)

1991-01-01

Presented here is a compilation of the final reports of the research projects done by the faculty members during the summer of 1991. Topics covered include optical correlation; lunar production and application of solar cells and synthesis of diamond film; software quality assurance; photographic image resolution; target detection using fractal geometry; evaluation of fungal metabolic compounds released to the air in a restricted environment; and planning and resource management in an intelligent automated power management system.

Astronaut Anna Fisher in NBS Training For Hubble Space Telescope

NASA Technical Reports Server (NTRS)

1980-01-01

The Hubble Space Telescope (HST) is a cooperative program of the European Space Agency (ESA) and the National Aeronautical and Space Administration (NASA) to operate a long-lived space-based observatory. It was the flagship mission of NASA's Great Observatories program. The HST program began as an astronomical dream in the 1940s. During the 1970s and 1980s, the HST was finally designed and built becoming operational in the 1990s. The HST was deployed into a low-Earth orbit on April 25, 1990 from the cargo bay of the Space Shuttle Discovery (STS-31). The design of the HST took into consideration its length of service and the necessity of repairs and equipment replacement by making the body modular. In doing so, subsequent shuttle missions could recover the HST, replace faulty or obsolete parts and be re-released. Marshall Space Flight Center's (MSFC's) Neutral Buoyancy Simulator (NBS) served as the test center for shuttle astronauts training for Hubble related missions. Shown is astronaut Anna Fisher training on a mock-up of a modular section of the HST for an axial scientific instrument change out.

The ineffectiveness of coumarin treatment on thermal oedema of macrophage-free rats.

PubMed Central

Piller, N. B.

1976-01-01

The administration of silica prevents coumarin-stimulated lysis of accumulated abnormal protein. This impairs the resolution of thermal oedema which is normally increased with coumarin administration. Evidence suggests that there is a rapid differentiation and infiltration of monocytes into the tissues and that these are selectively retained. This is aided by coumarin which increases tissue permeability. Coumarin also injures the vascular endothelium of some vessels, allowing extra protein and fluid into the tissues. Death of recently differentiated macrophages and subsequent release of their lysosomal contents into the extra-cellular spaces may be responsible for the changes in serum enzyme levels. It would seem that macrophages are the only cells in which coumarin stimulates increased phagocytosis, enzyme production and proteolysis. PMID:178336

28 CFR 2.86 - Release on parole; rescission for misconduct.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Release on parole; rescission for misconduct. 2.86 Section 2.86 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND... Parolees § 2.86 Release on parole; rescission for misconduct. (a) When a parole effective date has been set...

28 CFR 2.86 - Release on parole; rescission for misconduct.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Release on parole; rescission for misconduct. 2.86 Section 2.86 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND... Parolees § 2.86 Release on parole; rescission for misconduct. (a) When a parole effective date has been set...

28 CFR 2.86 - Release on parole; rescission for misconduct.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Release on parole; rescission for misconduct. 2.86 Section 2.86 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND... Parolees § 2.86 Release on parole; rescission for misconduct. (a) When a parole effective date has been set...

28 CFR 2.86 - Release on parole; rescission for misconduct.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Release on parole; rescission for misconduct. 2.86 Section 2.86 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND... Parolees § 2.86 Release on parole; rescission for misconduct. (a) When a parole effective date has been set...

28 CFR 2.86 - Release on parole; rescission for misconduct.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Release on parole; rescission for misconduct. 2.86 Section 2.86 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND... Parolees § 2.86 Release on parole; rescission for misconduct. (a) When a parole effective date has been set...

Advances in Nanotechnology for Efficacious and Stable Formulation Development

NASA Technical Reports Server (NTRS)

Putcha, Lakshimi

2012-01-01

Current operational medical kits aboard the International Space Station (ISS) include an array of medications intended for the treatment of minor ambulatory care symptoms, first aid, and basic life support. All medications contained in the flight kits are commercially available off-the-shelf formulations used for treatment of illnesses on Earth. However, transport and stowage of supplies including medications for space missions are exposed to adverse environmental conditions and extended shelf-life demands. Proposed missions to Mars and near-Earth objects such as asteroid 1999 AO10 will present crew health risk that is different both quantitatively and qualitatively from those encountered on ISS missions. Few drug options are available at the present time for mitigation of crew health risk of planned space exploration missions. Alternatives to standard oral formulations that include sustained and targeted delivery technologies for preventive healthcare in space will be a welcome addition to the space formulary and may include controlled release topical, sub-cutaneous, intranasal and inhalation dosage forms. An example of such a technology development endeavor can be nanotechnology-based multi-stage drug cocktail and vaccine delivery systems. Nanostructures also have the ability to protect drugs encapsulated within them from physiologic degradation, target their delivery with sustained release and are suitable for per oral routes of administration. The use of nanostructures such as polymeric nanoparticles offers a non-invasive approach for penetrating the blood brain barrier. Finally, nanotechnology offers great potential for the development of safe and efficacious drug delivery systems for preventive health care in space and on Earth.

77 FR 27272 - Land Release for Dunkirk Airport

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-09

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Land Release for Dunkirk Airport AGENCY: Federal Aviation Administration, DOT. ACTION: Notice, request for public comment. SUMMARY: The Federal Aviation Administration is requesting public comment on the Dunkirk Airport (DKK), Dunkirk, New...

Changes in FDA enforcement activities following changes in federal administration: the case of regulatory letters released to pharmaceutical companies.

PubMed

Nguyen, Diane; Seoane-Vazquez, Enrique; Rodriguez-Monguio, Rosa; Montagne, Michael

2013-01-22

The United States (US) Food and Drug Administration (FDA) is responsible for the protection of the public health by assuring the safety, effectiveness and security of human drugs and biological products through the enforcement of the Federal Food, Drug and Cosmetic Act (FDCA) and related regulations. These enforcement activities include regulatory letters (i.e. warning letters and notice of violation) to pharmaceutical companies. A regulatory letter represents the FDA's first official notification to a pharmaceutical company that the FDA has discovered a product or activity in violation of the FDCA.This study analyzed trends in the pharmaceutical-related regulatory letters released by the FDA during the period 1997-2011 and assessed differences in the average number and type of regulatory letters released during the last four federal administrations. Data derived from the FDA webpage. Information about the FDA office releasing the letter, date, company, and drug-related violation was collected. Regulatory letters were classified by federal administration. Descriptive statistics were performed for the analysis. Between 1997 and 2011 the FDA released 2,467 regulatory letters related to pharmaceuticals. FDA headquarters offices released 50.6% and district offices 49.4% of the regulatory letters. The Office of Prescription Drug Promotion released the largest number of regulatory letters (850; 34.5% of the total), followed by the Office of Scientific Investigations (131; 5.3%), and the Office of Compliance (105; 4.3%). During the 2nd Clinton Administration (1997-2000) the average number of regulatory letters per year was 242.8 ± 45.6, during the Bush Administration (2001-2008) it was 120.4 ± 33.7, and during the first three years of the Obama administration (2009-2011) it was 177.7.0 ± 17.0. The average number of regulatory letters released by the Office of Prescription Drug Promotion also varied by administration: Clinton (122.3 ± 36.4), Bush (29.5 ± 16.2) and Obama (41.7 ± 11.1). Most regulatory letters released by FDA headquarters were related to marketing and advertising activities of pharmaceutical companies. The number of regulatory letters was highest during the second Clinton administration, diminished during the Bush administrations, and increased again during the Obama administration. A further assessment of the impact of changes in federal administration on the enforcement activities of the FDA is required.

77 FR 4394 - Release of Airport Property: Orlando Executive Airport, Orlando, FL

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-27

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Release of Airport Property: Orlando Executive Airport, Orlando, FL AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Request for... 12.4 acres at the Orlando Executive Airport, Orlando, FL from the conditions, release certain...

KSC-99pp0881

NASA Image and Video Library

1999-07-19

KENNEDY SPACE CENTER, FLA. -- Members of the U.S. Women's World Cup Soccer Team are greeted by NASA Administrator Daniel S. Goldin as they disembark from a plane at the Skid Strip at Cape Canaveral Air Station. They arrived with First Lady Hillary Rodham Clinton to view the launch of Space Shuttle mission STS-93 scheduled for 12:36 a.m. EDT July 20. Much attention has been generated over the launch due to Commander Eileen M. Collins, the first woman to serve as commander of a Shuttle mission. The primary payload of the five-day mission is the release of the Chandra X-ray Observatory, which will allow scientists from around the world to study some of the most distant, powerful and dynamic objects in the universe

Astronaut Anna Fisher Suiting Up For NBS Training

NASA Technical Reports Server (NTRS)

1980-01-01

The Hubble Space Telescope (HST) is a cooperative program of the European Space Agency (ESA) and the National Aeronautical and Space Administration (NASA) to operate a long-lived space-based observatory. It was the flagship mission of NASA's Great Observatories program. The HST program began as an astronomical dream in the 1940s. During the 1970s and 1980s, the HST was finally designed and built becoming operational in the 1990s. The HST was deployed into a low-Earth orbit on April 25, 1990 from the cargo bay of the Space Shuttle Discovery (STS-31). The design of the HST took into consideration its length of service and the necessity of repairs and equipment replacement by making the body modular. In doing so, subsequent shuttle missions could recover the HST, replace faulty or obsolete parts and be re-released. Marshall Space Flight Center's (MSFC's) Neutral Buoyancy Simulator (NBS) served as the test center for shuttle astronauts training for Hubble related missions. Shown is astronaut Anna Fisher suiting up for training on a mockup of a modular section of the HST for an axial scientific instrument change out.

Astronaut Anna Fisher Suited Up For NBS Training

NASA Technical Reports Server (NTRS)

1980-01-01

The Hubble Space Telescope (HST) is a cooperative program of the European Space Agency (ESA) and the National Aeronautical and Space Administration (NASA) to operate a long-lived space-based observatory. It was the flagship mission of NASA's Great Observatories program. The HST program began as an astronomical dream in the 1940s. During the 1970s and 1980s, the HST was finally designed and built becoming operational in the 1990s. The HST was deployed into a low-Earth orbit on April 25, 1990 from the cargo bay of the Space Shuttle Discovery (STS-31). The design of the HST took into consideration its length of service and the necessity of repairs and equipment replacement by making the body modular. In doing so, subsequent shuttle missions could recover the HST, replace faulty or obsolete parts and be re-released. Marshall Space Flight Center's (MSFC's) Neutral Buoyancy Simulator (NBS) served as the test center for shuttle astronauts training for Hubble related missions. Shown is astronaut Anna Fisher suited up for training on a mockup of a modular section of the HST for an axial scientific instrument change out.

Astronaut Anna Fisher Suited Up For NBS Training

NASA Technical Reports Server (NTRS)

1980-01-01

The Hubble Space Telescope (HST) is a cooperative program of the European Space Agency (ESA) and the National Aeronautical and Space Administration (NASA) to operate a long-lived space-based observatory. It was the flagship mission of NASA's Great Observatories program. The HST program began as an astronomical dream in the 1940s. During the 1970s and 1980s, the HST was finally designed and built becoming operational in the 1990s. The HST was deployed into a low-Earth orbit on April 25, 1990 from the cargo bay of the Space Shuttle Discovery (STS-31). The design of the HST took into consideration its length of service and the necessity of repairs and equipment replacement by making the body modular. In doing so, subsequent shuttle missions could recover the HST, replace faulty or obsolete parts and be re-released. Marshall SPace Flight Center's (MSFC's) Neutral Buoyancy Simulator (NBS) served as the test center for shuttle astronauts training for Hubble related missions. Shown is astronaut Anna Fisher suited up for training on a mockup of a modular section of the HST for an axial scientific instrument change out.

Astronaut Anna Fisher Suits Up for NBS Training

NASA Technical Reports Server (NTRS)

1980-01-01

The Hubble Space Telescope (HST) is a cooperative program of the European Space Agency (ESA) and the National Aeronautical and Space Administration (NASA) to operate a long-lived space-based observatory. It was the flagship mission of NASA's Great Observatories program. The HST program began as an astronomical dream in the 1940s. During the 1970s and 1980s, the HST was finally designed and built becoming operational in the 1990s. The HST was deployed into a low-Earth orbit on April 25, 1990 from the cargo bay of the Space Shuttle Discovery (STS-31). The design of the HST took into consideration its length of service and the necessity of repairs and equipment replacement by making the body modular. In doing so, subsequent shuttle missions could recover the HST, replace faulty or obsolete parts and be re-released. Marshall Space Flight Center's (MSFC's) Neutral Buoyancy Simulator (NBS) served as the test center for shuttle astronauts training for Hubble related missions. Shown is astronaut Anna Fisher suiting up for training on a mockup of a modular section of the HST for an axial scientific instrument change out.

Astronaut Anna Fisher Suits Up For NBS Training

NASA Technical Reports Server (NTRS)

1980-01-01

The Hubble Space Telescope (HST) is a cooperative program of the European Space Agency (ESA) and the National Aeronautical and Space Administration (NASA) to operate a long-lived space-based observatory. It was the flagship mission of NASA's Great Observatories program. The HST program began as an astronomical dream in the 1940s. During the 1970s and 1980s, the HST was finally designed and built becoming operational in the 1990s. The HST was deployed into a low-Earth orbit on April 25, 1990 from the cargo bay of the Space Shuttle Discovery (STS-31). The design of the HST took into consideration its length of service and the necessity of repairs and equipment replacement by making the body modular. In doing so, subsequent shuttle missions could recover the HST, replace faulty or obsolete parts and be re-released. Marshall Space Flight Center's (MSFC's) Neutral Buoyancy Simulator (NBS) served as the test center for shuttle astronauts training for Hubble related missions. Shown is astronaut Anna Fisher suiting up for training on a mockup of a modular section of the HST for an axial scientific instrument change out.

White House and agencies focus on space weather concerns

NASA Astrophysics Data System (ADS)

Showstack, Randy

2012-06-01

"Space weather is a serious matter that can affect human economies around the world," Tamara Dickinson, a senior policy analyst with the White House Office of Science and Technology Policy (OSTP), told attendees at the 2012 Space Weather Enterprise Forum, held 5 June in Washington, D. C. With the 2013 solar maximum nearing, researchers and government agencies are focusing on how the greater solar activity could affect our increasingly technological society and what measures can be taken to help prevent or mitigate any threats to the electricity grid, GPS, and other potentially vulnerable technologies. Dickenson said that there has been an increased awareness about space weather in the White House and that President Barack Obama recently has requested briefing memos on the topic. She highlighted several efforts the administration is taking related to space weather, including a forthcoming national Earth observation strategy, which could be released in July and will include an assessment of space weather. She explained that the strategy document will be part of the fiscal year 2014 presidential budget request and that it will be updated every 3 years.

Neutral Buoyancy Test - Hubble Space Telescope Scientific Instruments (SI)

NASA Technical Reports Server (NTRS)

1979-01-01

The Hubble Space Telescope (HST) is a cooperative program of the European Space Agency (ESA) and the National Aeronautical and Space Administration (NASA) to operate a long-lived space-based observatory. It was the first and flagship mission of NASA's Great Observatories program. The HST program began as an astronomical dream in the 1940s. During the 1970s and 1980s, the HST was finally designed and built becoming operational in the 1990s. The HST was deployed into a low-Earth orbit on April 25, 1990 from the cargo bay of the Space Shuttle Discovery (STS-31). The design of the HST took into consideration its length of service and the necessity of repairs and equipment replacement by making the body modular. In doing so, subsequent shuttle missions could recover the HST, replace faulty or obsolete parts and be re-released. Pictured is MSFC's Neutral Buoyancy Simulator that served as the test center for shuttle astronauts training for Hubble related missions. Shown is an astronaut training on a mock-up of a modular section of the HST in the removal and replacement of scientific instruments.

Northeast Oregon Hatchery Project, Final Siting Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Watson, Montgomery

1995-03-01

This report presents the results of site analysis for the Bonneville Power Administration Northeast Oregon Hatchery Project. The purpose of this project is to provide engineering services for the siting and conceptual design of hatchery facilities for the Bonneville Power Administration. The hatchery project consists of artificial production facilities for salmon and steelhead to enhance production in three adjacent tributaries to the Columbia River in northeast Oregon: the Grande Ronde, Walla Walla, and Imnaha River drainage basins. Facilities identified in the master plan include adult capture and holding facilities; spawning incubation, and early rearing facilities; full-term rearing facilities; and directmore » release or acclimation facilities. The evaluation includes consideration of a main production facility for one or more of the basins or several smaller satellite production facilities to be located within major subbasins. The historic and current distribution of spring and fall chinook salmon and steelhead was summarized for the Columbia River tributaries. Current and future production and release objectives were reviewed. Among the three tributaries, forty seven sites were evaluated and compared to facility requirements for water and space. Site screening was conducted to identify the sites with the most potential for facility development. Alternative sites were selected for conceptual design of each facility type. A proposed program for adult holding facilities, final rearing/acclimation, and direct release facilities was developed.« less

28 CFR 2.12 - Initial hearings: Setting presumptive release dates.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Initial hearings: Setting presumptive release dates. 2.12 Section 2.12 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND RECOMMITMENT OF PRISONERS, YOUTH OFFENDERS, AND JUVENILE DELINQUENTS United States Code...

KSC-99pp1508

NASA Image and Video Library

1999-12-27

As he exits the Crew Hatch Access Vehicle, STS-103 Commander Curtis L. Brown Jr. is greeted with a handshake by Joseph Rothenberg, associate administrator, Office of Space Flight. Descending the stairs behind Brown are (left to right) Mission Specialists C. Michael Foale (Ph.D.) and John M. Grunsfeld (Ph.D.) and Pilot Scott J. Kelly. At right, applauding the astronauts return are Earle Huckins, deputy associate administrator, Office of Space Science, and Roy Bridges, director, Kennedy Space Center. Others in the crew (not shown) are Mission Specialists Steven L. Smith, and Jean-Francois Clervoy of France and Claude Nicollier of Switzerland, who are with the European Space Agency. The crew of seven completed a successful eight-day mission to service the Hubble Space Telescope, spending the Christmas holiday in space in order to accomplish their mission before the end of 1999. During the mission, Discovery's four space-walking astronauts, Smith, Foale, Grunsfeld and Nicollier, spent 24 hours and 33 minutes upgrading and refurbishing Hubble, making it more capable than ever to renew its observations of the universe. Mission objectives included replacing gyroscopes and an old computer, installing another solid state recorder, and replacing damaged insulation in the telescope. Hubble was released from the end of Discovery's robot arm on Christmas Day. Main gear touchdown was at 7:00:47 p.m. EST. Nose gear touchdown occurred at 7:00:58 p.m. EST and wheel stop at 7:01:34 p.m. EST. This was the 96th flight in the Space Shuttle program and the 27th for the orbiter Discovery. The landing was the 20th consecutive Shuttle landing in Florida and the 13th night landing in Shuttle program history

STS-103 crew is greeted after exiting the Crew Hatch Access Vehicle

NASA Technical Reports Server (NTRS)

1999-01-01

As he exits the Crew Hatch Access Vehicle, STS-103 Commander Curtis L. Brown Jr. is greeted with a handshake by Joseph Rothenberg, associate administrator, Office of Space Flight. Descending the stairs behind Brown are (left to right) Mission Specialists C. Michael Foale (Ph.D.) and John M. Grunsfeld (Ph.D.) and Pilot Scott J. Kelly. At right, applauding the astronauts return are Earle Huckins, deputy associate administrator, Office of Space Science, and Roy Bridges, director, Kennedy Space Center. Others in the crew (not shown) are Mission Specialists Steven L. Smith, and Jean-Francois Clervoy of France and Claude Nicollier of Switzerland, who are with the European Space Agency. The crew of seven completed a successful eight-day mission to service the Hubble Space Telescope, spending the Christmas holiday in space in order to accomplish their mission before the end of 1999. During the mission, Discovery's four space-walking astronauts, Smith, Foale, Grunsfeld and Nicollier, spent 24 hours and 33 minutes upgrading and refurbishing Hubble, making it more capable than ever to renew its observations of the universe. Mission objectives included replacing gyroscopes and an old computer, installing another solid state recorder, and replacing damaged insulation in the telescope. Hubble was released from the end of Discovery's robot arm on Christmas Day. Main gear touchdown was at 7:00:47 p.m. EST. Nose gear touchdown occurred at 7:00:58 EST and wheel stop at 7:01:34 EST. This was the 96th flight in the Space Shuttle program and the 27th for the orbiter Discovery. The landing was the 20th consecutive Shuttle landing in Florida and the 13th night landing in Shuttle program history.

Proceedings of the 36th Aerospace Mechanisms Symposium

NASA Technical Reports Server (NTRS)

Boesiger, Edward A. (Compiler); Oswald, Fred B. (Compiler)

2002-01-01

The Aerospace Mechanisms Symposium (AMS) provides a unique forum for those active in the design, production, and use of aerospace mechanisms. A major focus is the reporting of problems and solutions associated with the development and flight certification of new mechanisms. Organized by the Mechanisms Education Association, the National Aeronautics and Space Administration and Lockheed Martin Space Systems Company (LMSSC) share the responsibility for hosting the AMS. Now in its 36th year, the AMS continues to be well attended, attracting participants from both the United States and abroad. The 36th AMS, hosted by the Glenn Research Center (GRC) in Cleveland, Ohio, was held May 15, 16, and 17, 2002. During these three days, 32 papers were presented. Topics included deployment mechanisms, tribology, actuators, pointing and optical mechanisms, International Space Station mechanisms, release mechanisms, and test equipment. Hardware displays during the supplier exhibit gave attendees an opportunity to meet with developers of current and future mechanism components.

28 CFR 51.36 - Release of information concerning submissions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Release of information concerning submissions. 51.36 Section 51.36 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PROCEDURES FOR THE... Release of information concerning submissions. The Attorney General shall have the discretion to call to...

28 CFR 0.103 - Release of information.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Enforcement Administration § 0.103 Release of information. (a) The Administrator of DEA is authorized— (1) To release information obtained by DEA and DEA investigative reports to Federal, State, and local officials... by DEA and DEA investigative reports to Federal, State, and local prosecutors, and State licensing...

28 CFR 0.103 - Release of information.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Enforcement Administration § 0.103 Release of information. (a) The Administrator of DEA is authorized— (1) To release information obtained by DEA and DEA investigative reports to Federal, State, and local officials... by DEA and DEA investigative reports to Federal, State, and local prosecutors, and State licensing...

Space astronomy and astrophysics program by NASA

NASA Astrophysics Data System (ADS)

Hertz, Paul L.

2014-07-01

The National Aeronautics and Space Administration recently released the NASA Strategic Plan 20141, and the NASA Science Mission Directorate released the NASA 2014 Science Plan3. These strategic documents establish NASA's astrophysics strategic objectives to be (i) to discover how the universe works, (ii) to explore how it began and evolved, and (iii) to search for life on planets around other stars. The multidisciplinary nature of astrophysics makes it imperative to strive for a balanced science and technology portfolio, both in terms of science goals addressed and in missions to address these goals. NASA uses the prioritized recommendations and decision rules of the National Research Council's 2010 decadal survey in astronomy and astrophysics2 to set the priorities for its investments. The NASA Astrophysics Division has laid out its strategy for advancing the priorities of the decadal survey in its Astrophysics 2012 Implementation Plan4. With substantial input from the astrophysics community, the NASA Advisory Council's Astrophysics Subcommittee has developed an astrophysics visionary roadmap, Enduring Quests, Daring Visions5, to examine possible longer-term futures. The successful development of the James Webb Space Telescope leading to a 2018 launch is an Agency priority. One important goal of the Astrophysics Division is to begin a strategic mission, subject to the availability of funds, which follows from the 2010 decadal survey and is launched after the James Webb Space Telescope. NASA is studying a Wide Field Infrared Survey Telescope as its next large astrophysics mission. NASA is also planning to partner with other space agencies on their missions as well as increase the cadence of smaller Principal Investigator led, competitively selected Astrophysics Explorers missions.

U.S. Spacesuit Knowledge Capture Series Catalog

NASA Technical Reports Server (NTRS)

Bitterly, Rose; Oliva, Vladenka

2012-01-01

The National Aeronautics and Space Administration (NASA) and other organizations have been performing U.S. Spacesuit Knowledge Capture (USSKC) since the beginning of space exploration through published reports, conference presentations, specialized seminars, and classes instructed by veterans in the field. The close physical interaction between spacesuit systems and human beings makes them among the most personally evocative pieces of space hardware. Consequently, spacesuit systems have required nearly constant engineering refinements to do their jobs without impinging on human activity. Since 2008, spacesuit knowledge capture has occurred through video recording, engaging both current and former specialists presenting technical scope specifically to educate individuals and preserve knowledge. These archives of spacesuit legacy reflect its rich history and will provide knowledge that will enhance the chances for the success of future and more ambitious spacesuit system programs. The scope and topics of USSKC have included lessons learned in spacesuit technology; experience from the Gemini, Apollo, Skylab, and Shuttle Programs; the process of hardware certification, design, development, and other program components; spacesuit evolution and experience; failure analysis and resolution; and aspects of program management. USSKC activities have progressed to a level where NASA, the National Air and Space Museum (NASM), Hamilton Sundstrand (HS) and the spacesuit community are now working together to provide a comprehensive way to organize and archive intra-agency information related to the development of spacesuit systems. These video recordings are currently being reviewed for public release using NASA export control processes. After a decision is made for either public or non-public release (internal NASA only), the videos and presentations will be available through the NASA Johnson Space Center Engineering Directorate (EA) Engineering Academy, the NASA Technical Reports Server (NTRS), the NASA Aeronautics & Space Database (NA&SD), or NASA YouTube. Event availability is duly noted in this catalog.

28 CFR 51.36 - Release of information concerning submissions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Release of information concerning submissions. 51.36 Section 51.36 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PROCEDURES FOR THE ADMINISTRATION OF SECTION 5 OF THE VOTING RIGHTS ACT OF 1965, AS AMENDED Processing of Submissions § 51.36...

77 FR 41415 - Single-Ingredient, Immediate-Release Drug Products Containing Oxycodone for Oral Administration...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-13

... INFORMATION CONTACT: Astrid Lopez-Goldberg, Center for Drug Evaluation and Research, Food and Drug... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2012-N-0563] Single-Ingredient, Immediate-Release Drug Products Containing Oxycodone for Oral Administration and...

78 FR 66009 - Determination That INVEGA (Paliperidone) Extended-Release Tablet, 12 Milligrams, Was Not...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-04

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2013-P-0775... Reasons of Safety or Effectiveness AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) has determined that INVEGA (paliperidone) extended-release tablet...

Astronaut Anna Fisher Suiting Up For NBS Training

NASA Technical Reports Server (NTRS)

1980-01-01

The Hubble Space Telescope (HST) is a cooperative program of the European Space Agency (ESA) and the National Aeronautical and Space Administration (NASA) to operate a long-lived space-based observatory. It was the flagship mission of NASA's Great Observatories program. The HST program began as an astronomical dream in the 1940s. During the 1970s and 1980s, the HST was finally designed and built becoming operational in the 1990s. The HST was deployed into a low-Earth orbit on April 25, 1990 from the cargo bay of the Space Shuttle Discovery (STS-31). The design of the HST took into consideration its length of service and the necessity of repairs and equipment replacement by making the body modular. In doing so, subsequent shuttle missions could recover the HST, replace faulty or obsolete parts and be re-released. MSFC's Neutral Buoyancy Simulator (NBS) served as the test center for shuttle astronauts training for Hubble related missions. Shown is astronaut Anna Fisher suiting up for training on a mockup of a modular section of the HST for an axial scientific instrument change out.

CoNNeCT Antenna Positioning System Dynamic Simulator Modal Model Correlation

NASA Technical Reports Server (NTRS)

Jones, Tevor M.; McNelis, Mark E.; Staab, Lucas D.; Akers, James C.; Suarez, Vicente

2012-01-01

The National Aeronautics and Space Administration (NASA) developed an on-orbit, adaptable, Software Defined Radios (SDR)/Space Telecommunications Radio System (STRS)-based testbed facility to conduct a suite of experiments to advance technologies, reduce risk, and enable future mission capabilities on the International Space Station (ISS). The Communications, Navigation, and Networking reConfigurable Testbed (CoNNeCT) Project will provide NASA, industry, other Government agencies, and academic partners the opportunity to develop and field communications, navigation, and networking technologies in both the laboratory and space environment based on reconfigurable, software-defined radio platforms and the STRS Architecture. The CoNNeCT Payload Operations Nomenclature is "SCAN Testbed," and this nomenclature will be used in all ISS integration, safety, verification, and operations documentation. The SCAN Testbed (payload) is a Flight Releasable Attachment Mechanism (FRAM) based payload that will launch aboard the Japanese H-II Transfer Vehicle (HTV) Multipurpose Exposed Pallet (EP-MP) to the International Space Station (ISS), and will be transferred to the Express Logistics Carrier 3 (ELC3) via Extravehicular Robotics (EVR). The SCAN Testbed will operate on-orbit for a minimum of two years.

CoNNeCT Antenna Positioning System Dynamic Simulator Modal Model Correlation

NASA Technical Reports Server (NTRS)

Jones, Trevor M.; McNelis, Mark E.; Staab, Lucas D.; Akers, James C.; Suarez, Vicente J.

2012-01-01

The National Aeronautics and Space Administration (NASA) developed an on-orbit, adaptable, Software Defined Radios (SDR)/Space Telecommunications Radio System (STRS)-based testbed facility to conduct a suite of experiments to advance technologies, reduce risk, and enable future mission capabilities on the International Space Station (ISS). The Communications, Navigation, and Networking reConfigurable Testbed (CoNNeCT) Project will provide NASA, industry, other Government agencies, and academic partners the opportunity to develop and field communications, navigation, and networking technologies in both the laboratory and space environment based on reconfigurable, software-defined radio platforms and the STRS Architecture. The CoNNeCT Payload Operations Nomenclature is SCAN Testbed, and this nomenclature will be used in all ISS integration, safety, verification, and operations documentation. The SCAN Testbed (payload) is a Flight Releasable Attachment Mechanism (FRAM) based payload that will launch aboard the Japanese H-II Transfer Vehicle (HTV) Multipurpose Exposed Pallet (EP-MP) to the International Space Station (ISS), and will be transferred to the Express Logistics Carrier 3 (ELC3) via Extravehicular Robotics (EVR). The SCAN Testbed will operate on-orbit for a minimum of two years.

First Images From Chandra X-Ray Observatory to be Released

NASA Astrophysics Data System (ADS)

1999-08-01

The first images from the world's most powerful X-ray telescope, NASA's Chandra X-ray Observatory, will be unveiled at a media briefing at 1 p.m. EDT, Thursday, Aug. 26. The briefing will be held in the James E. Webb Auditorium at NASA Headquarters, 300 E St. SW, Washington, DC. The images include the spectacular remnants of a supernova and other astronomical objects. Panelists will be: - Dr. Edward Weiler, Associate Administrator for Space Science, NASA Headquarters, Washington, DC; - Dr. Harvey Tananbaum, Director of the Smithsonian Astrophysical Observatory's Chandra X-ray Center, Cambridge, MA; - Dr. Martin Weisskopf, NASA's Chandra Project Scientist, NASA's Marshall Space Flight Center, Huntsville, AL; and - Dr. Robert Kirshner, astrophysicist, Harvard University, Cambridge, MA. The event will be carried live on NASA Television with question-and-answer capability for reporters covering the briefing from participating NASA centers and from the Chandra Operations Control Center in Cambridge. NASA Television is available on transponder 9C, satellite GE-2 at 85 degrees West longitude, vertical polarization, frequency 3880 MHz, audio of 6.8 MHz. Chandra has been undergoing activation and checkout since it was placed into orbit during Space Shuttle mission STS-93 in July. Chandra will examine exploding stars, black holes, colliding galaxies and other high-energy cosmic phenomena to help scientists gain a better understanding of the structure and evolution of the universe. Chandra images and additional information will be available following the briefing on the Internet at: http://chandra.nasa.gov and http://chandra.harvard.edu NASA press releases and other information are available automatically by sending an Internet electronic mail message to domo@hq.nasa.gov. In the body of the message (not the subject line) users should type the words "subscribe press-release" (no quotes). The system will reply with a confirmation via E-mail of each subscription. A second automatic message will include additional information on the service. NASA releases also are available via CompuServe using the command GO NASA. To unsubscribe from this mailing list, address an E-mail message to domo@hq.nasa.gov, leave the subject blank, and type only "unsubscribe press-release" (no quotes) in the body of the message.

Chronic nicotine administration differentially affects neurotransmitter release from rat striatal slices.

PubMed

Yu, Z J; Wecker, L

1994-07-01

The objective of these experiments was to determine whether the chronic administration of nicotine, at a dose regimen that increases the density of nicotine binding sites, alters the nicotine-induced release of [3H]-dopamine ([3H]DA), [3H]norepinephrine ([3H]NE), [3H]-serotonin ([3H]5-HT), or [3H]acetylcholine ([3H]ACh) from rat striatal slices. For these experiments, rats received subcutaneous injections of either saline or nicotine bitartrate [1.76 mg (3.6 mumol)/kg, dissolved in saline] twice daily for 10 days, and neurotransmitter release was measured following preloading of the tissues with [3H]DA, [3H]NE, [3H]5-HT, or [3H]choline. Chronic nicotine administration did not affect the accumulation of tritium by striatal slices, the basal release of radioactivity, or the 25 mM KCl-evoked release of neurotransmitter. Superfusion of striatal slices with 1, 10, and 100 microM nicotine increased [3H]DA release in a concentration-dependent manner, and release from slices from nicotine-injected animals was significantly (p < 0.05) greater than release from saline-injected controls; release from the former increased to 132, 191, and 172% of release from the controls following superfusion with 1, 10, and 100 microM nicotine, respectively. Similarly, [3H]5-HT release increased in a concentration-related manner following superfusion with nicotine, and release from slices from nicotine-injected rats was significantly (p < 0.05) greater than that from controls. [3H]5-HT release from slices from nicotine-injected rats evoked by superfusion with 1 and 10 microM nicotine increased to 453 and 217%, respectively, of release from slices from saline-injected animals. The nicotine-induced release of [3H]NE from striatal slices was also concentration dependent but was unaffected by chronic nicotine administration.(ABSTRACT TRUNCATED AT 250 WORDS)

28 CFR 572.40 - Compassionate release under 18 U.S.C. 4205(g).

Code of Federal Regulations, 2011 CFR

2011-07-01

.... 4205(g)) § 572.40 Compassionate release under 18 U.S.C. 4205(g). 18 U.S.C. 4205(g) was repealed... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Compassionate release under 18 U.S.C. 4205(g). 572.40 Section 572.40 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE...

28 CFR 572.40 - Compassionate release under 18 U.S.C. 4205(g).

Code of Federal Regulations, 2010 CFR

2010-07-01

.... 4205(g)) § 572.40 Compassionate release under 18 U.S.C. 4205(g). 18 U.S.C. 4205(g) was repealed... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Compassionate release under 18 U.S.C. 4205(g). 572.40 Section 572.40 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE...

28 CFR 572.40 - Compassionate release under 18 U.S.C. 4205(g).

Code of Federal Regulations, 2014 CFR

2014-07-01

.... 4205(g)) § 572.40 Compassionate release under 18 U.S.C. 4205(g). 18 U.S.C. 4205(g) was repealed... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Compassionate release under 18 U.S.C. 4205(g). 572.40 Section 572.40 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE...

28 CFR 572.40 - Compassionate release under 18 U.S.C. 4205(g).

Code of Federal Regulations, 2013 CFR

2013-07-01

.... 4205(g)) § 572.40 Compassionate release under 18 U.S.C. 4205(g). 18 U.S.C. 4205(g) was repealed... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Compassionate release under 18 U.S.C. 4205(g). 572.40 Section 572.40 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE...

28 CFR 572.40 - Compassionate release under 18 U.S.C. 4205(g).

Code of Federal Regulations, 2012 CFR

2012-07-01

.... 4205(g)) § 572.40 Compassionate release under 18 U.S.C. 4205(g). 18 U.S.C. 4205(g) was repealed... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Compassionate release under 18 U.S.C. 4205(g). 572.40 Section 572.40 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE...

The role of reactive oxygen species in methamphetamine self-administration and dopamine release in the nucleus accumbens.

PubMed

Jang, Eun Young; Yang, Chae Ha; Hedges, David M; Kim, Soo Phil; Lee, Jun Yeon; Ekins, Tyler G; Garcia, Brandon T; Kim, Hee Young; Nelson, Ashley C; Kim, Nam Jun; Steffensen, Scott C

2017-09-01

Methamphetamine (METH) markedly increases dopamine (DA) release in the mesolimbic DA system, which plays an important role in mediating the reinforcing effects of METH. METH-induced DA release results in the formation of reactive oxygen species (ROS), leading to oxidative damage. We have recently reported that ROS are implicated in behavior changes and DA release in the nucleus accumbens (NAc) following cocaine administration. The aim of this study was to evaluate the involvement of ROS in METH-induced locomotor activity, self-administration and enhancement of DA release in the NAc. Systemic administration of a non-specific ROS scavenger, N-tert-butyl-α-phenylnitrone (PBN; 0, 50 and 75 mg/kg, IP) or a superoxide-selective scavenger, 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL; 0, 50 and 100 mg/kg, IP), attenuated METH-induced locomotor activity without affecting generalized behavior in METH-naïve rats. PBN and TEMPOL significantly attenuated METH self-administration without affecting food intake. Increased oxidative stress was found in neurons, but not astrocytes, microglia or oligodendrocytes, in the NAc of METH self-administering rats. In addition, TEMPOL significantly decreased METH enhancement of DA release in the NAc. Taken together, these results suggest that enhancement of ROS in the NAc contributes to the reinforcing effect of METH. © 2016 Society for the Study of Addiction.

Programs at risk

NASA Astrophysics Data System (ADS)

Jones, , R.

Declaring that “these lists represent the smoke behind which a fire may be raging,” Senator John Glenn (D.-Ohio), chairman of the Senate Government Affairs committee, has released a list prepared by the Office of Management and Budget of 73 government programs “in which hundreds of billions of federal dollars are at risk.”The National Aeronautics and Space Administration and Department of Energy are among the 16 federal departments and agencies having programs that Glenn feels could be “our next HUDs.” The secret list is not of programs where losses have occurred, but only where safeguards are thought to be insufficient.

Apparatus for releasably connecting first and second objects in predetermined space relationship

NASA Technical Reports Server (NTRS)

Chandler, J. A. (Inventor)

1984-01-01

A releasable apparatus that connects first and second space objects, such as a spacecraft and a space vehicle, in predetermined spaced relationship is described. The apparatus comprises at least one probe member mounted on the first object, having an elongated shank portion, the distal end of which is provided with a tapered nose portion. At least one drogue assembly is mounted on the second space object for releasably capturing the probe member upon the first and second objects being brought into close proximity with each other.

28 CFR 571.22 - Release clothing and transportation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Release clothing and transportation. 571... AND RELEASE RELEASE FROM CUSTODY Release Gratuities, Transportation, and Clothing § 571.22 Release clothing and transportation. (a) Staff shall provide release clothing appropriate for the time of year and...

28 CFR 571.22 - Release clothing and transportation.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Release clothing and transportation. 571... AND RELEASE RELEASE FROM CUSTODY Release Gratuities, Transportation, and Clothing § 571.22 Release clothing and transportation. (a) Staff shall provide release clothing appropriate for the time of year and...

28 CFR 571.22 - Release clothing and transportation.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Release clothing and transportation. 571... AND RELEASE RELEASE FROM CUSTODY Release Gratuities, Transportation, and Clothing § 571.22 Release clothing and transportation. (a) Staff shall provide release clothing appropriate for the time of year and...

28 CFR 571.22 - Release clothing and transportation.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Release clothing and transportation. 571... AND RELEASE RELEASE FROM CUSTODY Release Gratuities, Transportation, and Clothing § 571.22 Release clothing and transportation. (a) Staff shall provide release clothing appropriate for the time of year and...

28 CFR 571.22 - Release clothing and transportation.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Release clothing and transportation. 571... AND RELEASE RELEASE FROM CUSTODY Release Gratuities, Transportation, and Clothing § 571.22 Release clothing and transportation. (a) Staff shall provide release clothing appropriate for the time of year and...

77 FR 4370 - NASA Advisory Council; Commercial Space Committee; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-27

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (12-006)] NASA Advisory Council; Commercial Space Committee; Meeting AGENCY: National Aeronautics and Space Administration. ACTION: Notice of..., the National Aeronautics and Space Administration announces a meeting of the Commercial Space...

77 FR 20852 - NASA Advisory Council; Commercial Space Committee; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-06

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (12-027)] NASA Advisory Council; Commercial Space Committee; Meeting AGENCY: National Aeronautics and Space Administration. ACTION: Notice of..., the National Aeronautics and Space Administration announces a meeting of the Commercial Space...

Safe Manual Jettison

NASA Technical Reports Server (NTRS)

Barton, Jay

2008-01-01

In space, the controlled release of certain cargoes is no less useful than the maritime jettisons from which they take their name but is also much more dangerous. Experience has shown that jettisons can be performed safely, but the process is complicated with the path to performing a jettison taking months or even years. In the background, time is also required to write procedures, train the crew, configure the vehicle, and many other activities. This paper outlines the current process used by the National Aeronautics and Space Administration (NASA) for manual jettisons, detailing the methods used to assure that the jettisons and the jettisoned objects are as safe as achievable and that the crew is adequately trained to be able to affect the safe jettison. The goal of this paper is not only to capture what it takes to perform safe jettisons in the near Earth environment but to extrapolate this knowledge to future space exploration scenarios that will likely have Extravehicular Activity (EVA) and International Partner (IP) interfaces.

78 FR 77502 - NASA International Space Station Advisory Committee; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-23

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (13-154)] NASA International Space Station Advisory Committee; Meeting AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of..., the National Aeronautics and Space Administration announces a meeting of the NASA International Space...

78 FR 49296 - NASA International Space Station Advisory Committee; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-13

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 13-091] NASA International Space Station Advisory Committee; Meeting AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of..., the National Aeronautics and Space Administration announces a meeting of the NASA International Space...

76 FR 40753 - NASA Advisory Council; Commercial Space; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-11

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (11-061)] NASA Advisory Council; Commercial Space; Meeting AGENCY: National Aeronautics and Space Administration. ACTION: Notice of meeting. SUMMARY... Aeronautics and Space Administration announces a meeting of the Commercial Space Committee of the NASA...

Miniature Release Mechanism or Diminutive Assembly for Nanosatellite Deployables (DANY)

NASA Technical Reports Server (NTRS)

Santos Soto, Luis H. (Inventor); Hesh, Scott V. (Inventor); Hudeck, John D. (Inventor)

2017-01-01

Miniature release mechanisms constrain objects, such as deployables during the launch of space vehicles, such as small satellites and nanosatellites, and enable the release of the objects once a desired destination is reached by the space vehicle. Constraint and release of the objects are achieved by providing a secure threaded interface that may be released by the release mechanisms. The release mechanisms include a housing structure; a release block can include a threaded interface; one or more retracting pins; one or more release springs; a breakable link, such as a plastic link; a cable harness clamp; and a circuit board. The release mechanism can be 0.1875 inches (approximately 4.8 mm) thick.

Intracranial Biodegradable Silica-Based Nimodipine Drug Release Implant for Treating Vasospasm in Subarachnoid Hemorrhage in an Experimental Healthy Pig and Dog Model

PubMed Central

Koskimäki, Janne; Tarkia, Miikka; Ahtola-Sätilä, Tuula; Saloranta, Lasse; Laakso, Aki; Frantzén, Janek

2015-01-01

Nimodipine is a widely used medication for treating delayed cerebral ischemia (DCI) after subarachnoid hemorrhage. When administrated orally or intravenously, systemic hypotension is an undesirable side effect. Intracranial subarachnoid delivery of nimodipine during aneurysm clipping may be more efficient way of preventing vasospasm and DCI due to higher concentration of nimodipine in cerebrospinal fluid (CSF). The risk of systemic hypotension may also be decreased with intracranial delivery. We used animal models to evaluate the feasibility of surgically implanting a silica-based nimodipine releasing implant into the subarachnoid space through a frontotemporal craniotomy. Concentrations of released nimodipine were measured from plasma samples and CSF samples. Implant degradation was followed using CT imaging. After completing the recovery period, full histological examination was performed on the brain and meninges. The in vitro characteristics of the implant were determined. Our results show that the biodegradable silica-based implant can be used for an intracranial drug delivery system and no major histopathological foreign body reactions were observed. CT imaging is a feasible method for determining the degradation of silica implants in vivo. The sustained release profiles of nimodipine in CSF were achieved. Compared to a traditional treatment, higher nimodipine CSF/plasma ratios can be obtained with the implant. PMID:25685803

Aerosol emission monitoring in the production of silicon carbide nanoparticles by induction plasma synthesis

NASA Astrophysics Data System (ADS)

Thompson, Drew; Leparoux, Marc; Jaeggi, Christian; Buha, Jelena; Pui, David Y. H.; Wang, Jing

2013-12-01

In this study, the synthesis of silicon carbide (SiC) nanoparticles in a prototype inductively coupled thermal plasma reactor and other supporting processes, such as the handling of precursor material, the collection of nanoparticles, and the cleaning of equipment, were monitored for particle emissions and potential worker exposure. The purpose of this study was to evaluate the effectiveness of engineering controls and best practice guidelines developed for the production and handling of nanoparticles, identify processes which result in a nanoparticle release, characterize these releases, and suggest possible administrative or engineering controls which may eliminate or control the exposure source. No particle release was detected during the synthesis and collection of SiC nanoparticles and the cleaning of the reactor. This was attributed to most of these processes occurring in closed systems operated at slight underpressure. Other tasks occurring in more open spaces, such as the disconnection of a filter assembly from the reactor system and the use of compressed air for the cleaning of filters where synthesized SiC nanoparticles were collected, resulted in releases of submicrometer particles with a mode size of 170-180 nm. Observation of filter samples under scanning electron microscope confirmed that the particles were agglomerates of SiC nanoparticles.

76 FR 6827 - Public Availability of the National Aeronautic and Space Administration FY 2010 Service Contract...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-08

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION Public Availability of the National Aeronautic and Space Administration FY 2010 Service Contract Inventory AGENCY: National Aeronautic and Space Administration. ACTION: Notice of public availability of FY 2010 Service Contract Inventories. [[Page 6828...

49 CFR 1244.9 - Procedures for the release of waybill data.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Director of the Office of Economics, Environmental Analysis, and Administration shall be responsible for... Board's Office of Economics, Environmental Analysis, and Administration. (3) Objections to release. (i... copies of each objection shall be filed with the Director, Office of Economics, Environmental Analysis...

49 CFR 1244.9 - Procedures for the release of waybill data.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Director of the Office of Economics, Environmental Analysis, and Administration shall be responsible for... Board's Office of Economics, Environmental Analysis, and Administration. (3) Objections to release. (i... copies of each objection shall be filed with the Director, Office of Economics, Environmental Analysis...

49 CFR 1244.9 - Procedures for the release of waybill data.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Director of the Office of Economics, Environmental Analysis, and Administration shall be responsible for... Board's Office of Economics, Environmental Analysis, and Administration. (3) Objections to release. (i... copies of each objection shall be filed with the Director, Office of Economics, Environmental Analysis...

49 CFR 1244.9 - Procedures for the release of waybill data.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Director of the Office of Economics, Environmental Analysis, and Administration shall be responsible for... Board's Office of Economics, Environmental Analysis, and Administration. (3) Objections to release. (i... copies of each objection shall be filed with the Director, Office of Economics, Environmental Analysis...

40 CFR 68.39 - Documentation.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., and the rationale for selection; assumptions shall include use of any administrative controls and any... include the anticipated effect of the controls and mitigation on the release quantity and rate. (b) For... administrative controls and any mitigation that were assumed to limit the quantity that could be released...

40 CFR 68.39 - Documentation.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., and the rationale for selection; assumptions shall include use of any administrative controls and any... include the anticipated effect of the controls and mitigation on the release quantity and rate. (b) For... administrative controls and any mitigation that were assumed to limit the quantity that could be released...

40 CFR 68.39 - Documentation.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., and the rationale for selection; assumptions shall include use of any administrative controls and any... include the anticipated effect of the controls and mitigation on the release quantity and rate. (b) For... administrative controls and any mitigation that were assumed to limit the quantity that could be released...

40 CFR 68.39 - Documentation.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., and the rationale for selection; assumptions shall include use of any administrative controls and any... include the anticipated effect of the controls and mitigation on the release quantity and rate. (b) For... administrative controls and any mitigation that were assumed to limit the quantity that could be released...

40 CFR 68.39 - Documentation.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., and the rationale for selection; assumptions shall include use of any administrative controls and any... include the anticipated effect of the controls and mitigation on the release quantity and rate. (b) For... administrative controls and any mitigation that were assumed to limit the quantity that could be released...

14 CFR 120.111 - Administrative and other matters.

Code of Federal Regulations, 2014 CFR

2014-01-01

... ALCOHOL TESTING PROGRAM Drug Testing Program Requirements § 120.111 Administrative and other matters. (a... for the employer must be produced at the employer's place of business. (c) Release of drug testing information. An employer shall release information regarding an employee's drug testing results, evaluation...

14 CFR 120.111 - Administrative and other matters.

Code of Federal Regulations, 2012 CFR

2012-01-01

... ALCOHOL TESTING PROGRAM Drug Testing Program Requirements § 120.111 Administrative and other matters. (a... for the employer must be produced at the employer's place of business. (c) Release of drug testing information. An employer shall release information regarding an employee's drug testing results, evaluation...

14 CFR 120.111 - Administrative and other matters.

Code of Federal Regulations, 2010 CFR

2010-01-01

... ALCOHOL TESTING PROGRAM Drug Testing Program Requirements § 120.111 Administrative and other matters. (a... for the employer must be produced at the employer's place of business. (c) Release of drug testing information. An employer shall release information regarding an employee's drug testing results, evaluation...

14 CFR 120.111 - Administrative and other matters.

Code of Federal Regulations, 2013 CFR

2013-01-01

... ALCOHOL TESTING PROGRAM Drug Testing Program Requirements § 120.111 Administrative and other matters. (a... for the employer must be produced at the employer's place of business. (c) Release of drug testing information. An employer shall release information regarding an employee's drug testing results, evaluation...

14 CFR 120.111 - Administrative and other matters.

Code of Federal Regulations, 2011 CFR

2011-01-01

... ALCOHOL TESTING PROGRAM Drug Testing Program Requirements § 120.111 Administrative and other matters. (a... for the employer must be produced at the employer's place of business. (c) Release of drug testing information. An employer shall release information regarding an employee's drug testing results, evaluation...

49 CFR 1244.9 - Procedures for the release of waybill data.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Director of the Office of Economics, Environmental Analysis, and Administration shall be responsible for... Board's Office of Economics, Environmental Analysis, and Administration. (3) Objections to release. (i... copies of each objection shall be filed with the Director, Office of Economics, Environmental Analysis...

Beer self-administration provokes lateralized nucleus accumbens dopamine release in male heavy drinkers.

PubMed

Oberlin, Brandon G; Dzemidzic, Mario; Tran, Stella M; Soeurt, Christina M; O'Connor, Sean J; Yoder, Karmen K; Kareken, David A

2015-03-01

Although striatal dopamine (DA) is important in alcohol abuse, the nature of DA release during actual alcohol drinking is unclear, since drinking includes self-administration of both conditioned flavor stimuli (CS) of the alcoholic beverage and subsequent intoxication, the unconditioned stimulus (US). Here, we used a novel self-administration analog to distinguish nucleus accumbens (NAcc) DA responses specific to the CS and US. Right-handed male heavy drinkers (n = 26) received three positron emission tomography (PET) scans with the D2/D3 radioligand [(11)C]raclopride (RAC) and performed a pseudo self-administration task that separately administered a flavor CS of either a habitually consumed beer or the appetitive control Gatorade®, concomitant with the US of ethanol intoxication (0.06 g/dL intravenous (IV) administration) or IV saline. Scan conditions were Gatorade flavor + saline (Gat&Sal), Gatorade flavor + ethanol (Gat&Eth), and beer flavor + ethanol (Beer&Eth). Ethanol (US) reduced RAC binding (inferring DA release) in the left (L) NAcc [Gat&Sal > Gat&Eth]. Beer flavor (CS) increased DA in the right (R) NAcc [Gat&Eth > Beer&Eth]. The combination of beer flavor and ethanol (CS + US), [Gat&Sal > Beer&Eth], induced DA release in bilateral NAcc. Self-reported intoxication during scanning correlated with L NAcc DA release. Relative to saline, infusion of ethanol increased alcoholic drink wanting. Our findings suggest lateralized DA function in the NAcc, with L NAcc DA release most reflecting intoxication, R NAcc DA release most reflecting the flavor CS, and the conjoint CS + US producing a bilateral NAcc response.

77 FR 2765 - NASA International Space Station Advisory Committee; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-19

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (12-003)] NASA International Space Station Advisory Committee; Meeting AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of..., the National Aeronautics and Space Administration announces an open meeting of the NASA International...

77 FR 41203 - NASA International Space Station Advisory Committee; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-12

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 12-057] NASA International Space Station Advisory Committee; Meeting AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of..., the National Aeronautics and Space Administration announces an open meeting of the NASA International...

77 FR 66082 - NASA International Space Station Advisory Committee; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-01

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 12-090] NASA International Space Station Advisory Committee; Meeting AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of..., the National Aeronautics and Space Administration announces an open meeting of the NASA International...

75 FR 51852 - NASA International Space Station Advisory Committee; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-23

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-090)] NASA International Space Station Advisory Committee; Meeting AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of..., the National Aeronautics and Space Administration announces an open meeting of the NASA International...

75 FR 51853 - NASA Advisory Council; Space Operations Committee; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-23

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-092)] NASA Advisory Council; Space Operations Committee; Meeting AGENCY: National Aeronautics and Space Administration. ACTION: Notice of..., the National Aeronautics and Space Administration announces a meeting of the NASA Advisory Council...

77 FR 7183 - Public Availability of the National Aeronautics and Space Administration FY 2011 Service Contract...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-10

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION Public Availability of the National Aeronautics and Space Administration FY 2011 Service Contract Inventory AGENCY: National Aeronautics and Space Administration. ACTION: Notice of Public Availability of Analysis of the FY 2010 Service Contract Inventories and...

78 FR 13383 - Public Availability of the National Aeronautics and Space Administration FY 2012 Service Contract...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-27

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION Public Availability of the National Aeronautics and Space Administration FY 2012 Service Contract Inventory (SCI) AGENCY: Office of Procurement, National Aeronautics and Space Administration. ACTION: Notice of Public Availability of the FY 2012 Service Contract...

ACTH releasing activity of KP-102 (GHRP-2) in rats is mediated mainly by release of CRF.

PubMed

Hirotani, Chiharu; Oki, Yutaka; Ukai, Kiyoharu; Okuno, Tadashi; Kurasaki, Shigeru; Ohyama, Tadashi; Doi, Naomi; Sasaki, Ken; Ase, Katsuhiko

2005-01-01

KP-102 (GHRP-2: pralmorelin) is a synthetic growth hormone releasing peptide (GHRP) that powerfully stimulates the release of GH by acting (i.v.) at both hypothalamic and pituitary sites. Intravenous (i.v.) administration of KP-102 also elicits slight but significant release of adrenocorticotropic hormone (ACTH) in both animals and humans, as is seen with other GHRPs. GHRPs are thought to stimulate the hypothalamic-pituitary-adrenal axis by releasing endogenous ACTH secretagogues such as arginine vasopressin (AVP) and/or corticotropin releasing factor (CRF), though neither AVP nor CRF has been shown clearly to be involved significantly in GHRP-evoked ACTH release. In the present study, we investigated the effects of KP-102 on ACTH release in conscious rats under improved experimental conditions that minimized the influence of stress. Administration of KP-102 i.v. increased plasma ACTH significantly, but did not stimulate ACTH release from rat primary pituitary cells. Administration of KP-102 together with either AVP or CRF elicited significantly greater increases in plasma ACTH levels than any of the agonists alone. Notably, the combination of KP-102 and AVP produced a much greater increase in ACTH than KP-102 plus CRF, indicating that KP-102 augments the effect of exogenous CRF only weakly. Conversely, a CRF antagonist markedly inhibited KP-102-induced ACTH release in conscious rats, whereas an AVP antagonist or anti-AVP antiserum did not. Taken together, these findings suggest that KP-102 acts via the hypothalamus to stimulate ACTH release in rats, and that these effects are mediated mainly by the release of CRF.

Twice-weekly administration of kisspeptin-54 for 8 weeks stimulates release of reproductive hormones in women with hypothalamic amenorrhea.

PubMed

Jayasena, C N; Nijher, G M K; Abbara, A; Murphy, K G; Lim, A; Patel, D; Mehta, A; Todd, C; Donaldson, M; Trew, G H; Ghatei, M A; Bloom, S R; Dhillo, W S

2010-12-01

Kisspeptin is a novel therapeutic target for infertility. A single kisspeptin-54 (KP-54) injection acutely stimulates the release of reproductive hormones in women with hypothalamic amenorrhea (HA), a commonly occurring condition characterized by absence of menstruation; however, twice-daily administration of KP-54 results in tachyphylaxis. We determined the time course of desensitization to twice-daily KP-54 injections, compared the effects of twice-daily and twice-weekly administration regimens of KP-54, and studied the effects of long-term twice-weekly administration of KP-54 on the release of reproductive hormones in women with HA. When KP-54 was administered twice daily, responsiveness to luteinizing hormone (LH) diminished gradually, whereas responsiveness to follicle-stimulating hormone (FSH) was nearly abolished by day 2. Twice-weekly KP-54 administration resulted in only partial desensitization, in contrast to the complete tolerance achieved with twice-daily administration. Women with HA who were treated with twice-weekly KP-54 injections had significantly elevated levels of reproductive hormones after 8 weeks as compared with treatment with saline. No adverse effects were observed. This study provides novel pharmacological data on the effects of KP-54 on the release of reproductive hormones in women with HA.

78 FR 38533 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-68; Introduction

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-26

... Administration National Aeronautics and Space Administration 48 CFR Chapter 1 Federal Acquisition Regulations... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION 48 CFR Chapter 1 [Docket FAR 2013-0076, Sequence 4] Federal...), General Services Administration (GSA), and National Aeronautics and Space Administration (NASA). ACTION...

77 FR 73515 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-63; Introduction

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-10

... Administration National Aeronautics and Space Administration 48 CFR Chapter 1 Federal Acquisition Regulations... AND SPACE ADMINISTRATION 48 CFR Chapter 1 [Docket FAR 2012-0080, Sequence 6] Federal Acquisition... Services Administration (GSA), and National Aeronautics and Space Administration (NASA). ACTION: Summary...

14 CFR 1201.103 - Administration.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Administration. 1201.103 Section 1201.103 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1201.103 Administration. (a) NASA is headed by an Administrator, who is appointed...

75 FR 19179 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-41; Small Entity Compliance Guide

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-13

... DEPARTMENT OF DEFENSE GENERAL SERVICES ADMINISTRATION NATIONAL AERONAUTICS AND SPACE... Services Administration (GSA), and National Aeronautics and Space Administration (NASA). ACTION: Small... Defense, the Administrator of General Services and the Administrator of the National Aeronautics and Space...

14 CFR 1201.103 - Administration.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Administration. 1201.103 Section 1201.103 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1201.103 Administration. (a) NASA is headed by an Administrator, who is appointed...

14 CFR 1201.103 - Administration.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Administration. 1201.103 Section 1201.103 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1201.103 Administration. (a) NASA is headed by an Administrator, who is appointed...

14 CFR 1201.103 - Administration.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Administration. 1201.103 Section 1201.103 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1201.103 Administration. (a) NASA is headed by an Administrator, who is appointed...

5 CFR 1216.208 - Restrictions that apply to released records.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Restrictions that apply to released records. 1216.208 Section 1216.208 Administrative Personnel MERIT SYSTEMS PROTECTION BOARD ORGANIZATION... RECORDS IN LEGAL PROCEEDINGS Demands or Requests for Testimony and Production of Documents § 1216.208...

28 CFR 541.68 - Release from controlled housing status.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Release from controlled housing status. 541.68 Section 541.68 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT INMATE DISCIPLINE AND SPECIAL HOUSING UNITS Procedures for Handling of HIV Positive Inmates Who...

28 CFR 541.68 - Release from controlled housing status.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Release from controlled housing status. 541.68 Section 541.68 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT INMATE DISCIPLINE AND SPECIAL HOUSING UNITS Procedures for Handling of HIV Positive Inmates Who...

28 CFR 541.68 - Release from controlled housing status.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Release from controlled housing status. 541.68 Section 541.68 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT INMATE DISCIPLINE AND SPECIAL HOUSING UNITS Procedures for Handling of HIV Positive Inmates Who...

28 CFR 541.68 - Release from controlled housing status.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Release from controlled housing status. 541.68 Section 541.68 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT INMATE DISCIPLINE AND SPECIAL HOUSING UNITS Procedures for Handling of HIV Positive Inmates Who...

28 CFR 541.68 - Release from controlled housing status.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Release from controlled housing status. 541.68 Section 541.68 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT INMATE DISCIPLINE AND SPECIAL HOUSING UNITS Procedures for Handling of HIV Positive Inmates Who...

3 CFR - Designation of Officers of the National Aeronautics And Space Administration To Act as Administrator

Code of Federal Regulations, 2010 CFR

2010-01-01

... 3 The President 1 2010-01-01 2010-01-01 false Designation of Officers of the National Aeronautics And Space Administration To Act as Administrator Presidential Documents Other Presidential Documents Memorandum of January 16, 2009 Designation of Officers of the National Aeronautics And Space Administration To Act as Administrator Memorandum for...

A Snowy Entrance

NASA Image and Video Library

2016-10-27

This archival image was released as part of a gallery comparing JPL's past and present, commemorating the 80th anniversary of NASA's Jet Propulsion Laboratory on Oct. 31, 2016. This photograph from 1949 shows the main entrance gate to the Jet Propulsion Laboratory in Pasadena, California, after a snowstorm. To the left is JPL's administration building at the time (Building 67). Building 67 is the Materials Research Building today. The Space Flight Operations Facility (Building 230), which houses JPL's Mission Control, now stands over the parking area on the right. As the lab expanded, the main entrance gate moved farther south. http://photojournal.jpl.nasa.gov/catalog/PIA21118

Gq-DREADD Selectively Initiates Glial Glutamate Release and Inhibits Cue-induced Cocaine Seeking

PubMed Central

Scofield Michael, D.; Boger Heather, A.; Smith Rachel, J.; Li, Hao; Haydon Philip, G.; Kalivas Peter, W.

2015-01-01

Background Glial cells of the central nervous system directly influence neuronal activity by releasing neuroactive small molecules, including glutamate. Long-lasting cocaine-induced reductions in extracellular glutamate in the nucleus accumbens core (NAcore) affect synaptic plasticity responsible for relapse vulnerability. Methods We transduced NAcore astrocytes with an AAV viral vector expressing hM3Dq (Gq) DREADD under control of the glial fibrillary acidic protein (GFAP) promoter in 62 male Sprague Dawley rats, 4 dnSNARE mice and 4 wild type littermates. Using glutamate biosensors we measured NAcore glutamate levels following intracranial or systemic administration of clozapine-N-oxide (CNO), and tested the ability of systemic CNO to inhibit reinstated cocaine or sucrose seeking following self-administration (SA) and extinction training. Results Administration of CNO in GFAP-Gq-DREADD transfected animals increased NAcore extracellular glutamate levels in vivo. The glial origin of released glutamate was validated by an absence of CNO-mediated release in mice expressing a dominant-negative SNARE variant in glia. Also, CNO-mediated release was relatively insensitive to N-type calcium channel blockade. Systemic administration of CNO inhibited cue-induced reinstatement of cocaine seeking in rats extinguished from cocaine, but not sucrose SA. The capacity to inhibit reinstated cocaine-seeking was prevented by systemic administration of the group II metabotropic glutamate receptor (mGluR2/3) antagonist LY341495. Conclusions DREADD-mediated glutamate gliotransmission inhibited cue-induced reinstatement of cocaine seeking by stimulating release-regulating mGluR2/3 autoreceptors to inhibit cue-induced synaptic glutamate spillover. PMID:25861696

14 CFR § 1201.103 - Administration.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Administration. § 1201.103 Section § 1201.103 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1201.103 Administration. (a) NASA is headed by an Administrator, who is...

78 FR 13478 - Compassionate Release; Technical Changes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-28

... (Bureau) makes a minor change to remove an administrative level of review from the processing of a... interim rule, the Bureau of Prisons (Bureau) makes a minor change to remove an administrative level of review from the processing of a Compassionate Release request packet. DATES: This rule is effective April...

2011 National Drug Control Strategy. Executive Summary

ERIC Educational Resources Information Center

Office of National Drug Control Policy, 2011

2011-01-01

In May of 2010, President Obama released the Administration's inaugural "National Drug Control Strategy", a comprehensive approach to combat the public health and safety consequences posed by drug use. Now, a year later, the Administration is releasing its update building upon that initial "Strategy". The "Strategy" establishes ambitious goals to…

77 FR 19132 - Federal Motor Vehicle Safety Standards; Bus Emergency Exits and Window Retention and Release

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-30

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration 49 CFR Part 571 [Docket No. NHTSA-2012-0037] RIN 2127-AK20 Federal Motor Vehicle Safety Standards; Bus Emergency Exits and Window Retention and Release AGENCY: National Highway Traffic Safety Administration (NHTSA), Department...

38th Aerospace Mechanisms Symposium

NASA Technical Reports Server (NTRS)

Boesiger, Edward A. (Compiler)

2006-01-01

The Aerospace Mechanisms Symposium (AMS) provides a unique forum for those active in the design, production and use of aerospace mechanisms. A major focus is the reporting of problems and solutions associated with the development and flight certification of new mechanisms. Organized by the Mechanisms Education Association, the National Aeronautics and Space Administration and Lockheed Martin Space Systems Company (LMSSC) share the responsibility for hosting the AMS. Now in its 38th symposium, the AMS continues to be well attended, attracting participants from both the U.S. and abroad. The 38th AMs, hosted by the NASA Langley Research Center in Williamsburg, Virginia, was held May 17-19, 2006. During these three days, 34 papers were presented. Topics included gimbals, tribology, actuators, aircraft mechanisms, deployment mechanisms, release mechanisms, and test equipment. Hardware displays during the supplier exhibit gave attendees an opportunity to meet with developers of current and future mechanism components.

28 CFR 2.83 - Release planning.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Release planning. 2.83 Section 2.83... Release planning. (a) All grants of parole shall be conditioned on the development of a suitable release... parole date for purposes of release planning for up to 120 days without a hearing. If efforts to...

5 CFR 351.601 - Order of release from competitive level.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Order of release from competitive level... REGULATIONS REDUCTION IN FORCE Release From Competitive Level § 351.601 Order of release from competitive level. (a) Each agency must select competing employees for release from a competitive level (including...

5 CFR 351.601 - Order of release from competitive level.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Order of release from competitive level... REGULATIONS REDUCTION IN FORCE Release From Competitive Level § 351.601 Order of release from competitive level. (a) Each agency must select competing employees for release from a competitive level (including...

Hypothalamic interactions between neuropeptide Y, agouti-related protein, cocaine- and amphetamine-regulated transcript and alpha-melanocyte-stimulating hormone in vitro in male rats.

PubMed

Dhillo, W S; Small, C J; Stanley, S A; Jethwa, P H; Seal, L J; Murphy, K G; Ghatei, M A; Bloom, S R

2002-09-01

A number of neuropeptides implicated in the hypothalamic regulation of appetite are synthesized in the arcuate nucleus (Arc). Neuropeptide Y (NPY) and agouti-related protein (Agrp) are orexigenic. The pro-opiomelanocortin (POMC) product alpha-melanocyte-stimulating hormone (alpha-MSH) is anorectic. Intracerebroventricular administration of cocaine- and amphetamine-regulated transcript (CART) decreases food intake. However, recent results show that CART is orexigenic when injected into discrete hypothalamic nuclei. There is almost complete coexpression of NPY and Agrp mRNA in Arc neurones, and the majority of CART-containing neurones in the Arc also contain POMC mRNA. We investigated possible interactions between these neuropeptides in vitro using a rat hypothalamic explant system. Administration of 1, 10 and 100 nm of NPY to hypothalamic explants significantly increased release of Agrp(83-132)-immunoreactivity (IR). NPY (10 and 100 nm) significantly increased the release of CART(55-102)-IR and alpha-MSH-IR from hypothalamic explants. Agrp(83-132) (10 nm) administered to hypothalamic explants significantly increased the release of NPY-IR. Agrp(83-132) (10 and 100 nm) significantly decreased the release of CART(55-102)-IR from hypothalamic explants. Administration of 1, 10 and 100 nm CART(55-102) to hypothalamic explants resulted in a significant increase in NPY-IR release. Administration of 10 nm CART(55-102) to hypothalamic explants significantly increased the release of Agrp(83-132)-IR. NDP-MSH (10 nm) administered to hypothalamic explants significantly increased the release of NPY-IR. NDP-MSH (10 and 100 nm) significantly increased the release of Agrp(83-132)-IR from hypothalamic explants. These data suggest that orexigenic neuropeptides in the arcuate nucleus stimulate the release of each other, perhaps reinforcing orexigenic behaviour via a positive-feedback loop. Our results are also in keeping with the possibility that the melanocortin-3 receptor in the arcuate nucleus may influence the release of arcuate neuropeptides.

Nez Perce Tribal Hatchery Program : Draft Environmental Impact Statement.

DOE Office of Scientific and Technical Information (OSTI.GOV)

United States. Bonneville Power Administration; Nez Perce Tribal Hatchery

1996-06-01

Bonneville Power Administration, the Bureau of Indian Affairs, the Nez Perce Tribe propose a supplementation program to restore chinook salmon to the Clearwater River Subbasin in Idaho. The Clearwater River is a tributary to the Snake River, which empties into the Columbia River. The Nez Perce Tribe would build and operate two central incubation and rearing hatcheries and six satellite facilities. Spring, summer and fall chinook salmon would be reared and acclimated to different areas in the Subbasin and released at the hatchery and satellite sites or in other watercourses throughout the Subbasin. The supplementation program differs from other hatcherymore » programs because the fish would be released at different sizes and would return to reproduce naturally in the areas where they are released. Several environmental issues were identified during scoping: the possibility that the project would fail if mainstem Columbia River juvenile and adult passage problems are not solved; genetic risks to fish listed as endangered or threatened; potential impacts to wild and resident fish stocks because of increase competition for food and space; and water quality. The Proposed Action would affect several important aspects of Nez Perce tribal life, primarily salmon harvest, employment, and fisheries management.« less

78 FR 61399 - Notice of Intent To Grant Exclusive Research License

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-03

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 13-118] Notice of Intent To Grant Exclusive Research License AGENCY: National Aeronautics and Space Administration. ACTION: Notice of intent to grant... the Administrator of the National Aeronautics and Space Administration. The prospective exclusive...

14 CFR 1212.705 - Assistant Administrator for Procurement.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Assistant Administrator for Procurement. 1212.705 Section 1212.705 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PRIVACY ACT-NASA REGULATIONS NASA Authority and Responsibilities § 1212.705 Assistant Administrator for...

14 CFR 1212.701 - Assistant Deputy Administrator.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Assistant Deputy Administrator. 1212.701 Section 1212.701 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PRIVACY ACT-NASA REGULATIONS NASA Authority and Responsibilities § 1212.701 Assistant Deputy Administrator. The Assistant...

14 CFR 1212.705 - Assistant Administrator for Procurement.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Assistant Administrator for Procurement. 1212.705 Section 1212.705 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PRIVACY ACT-NASA REGULATIONS NASA Authority and Responsibilities § 1212.705 Assistant Administrator for...

14 CFR 1212.701 - Assistant Deputy Administrator.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Assistant Deputy Administrator. 1212.701 Section 1212.701 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PRIVACY ACT-NASA REGULATIONS NASA Authority and Responsibilities § 1212.701 Assistant Deputy Administrator. The Assistant...

21 CFR 1316.92 - Petition for expedited release in an administrative forfeiture action.

Code of Federal Regulations, 2010 CFR

2010-04-01

... for expedited release shall establish the following: (1) The owner has a valid, good faith interest in..., which would be subject to seizure for administrative forfeiture for a violation of law involving... in the property, which shall be supported by title documentation, bills of sale, contracts, mortgages...

SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma

PubMed Central

Robert, Stephanie M.; Buckingham, Susan C.; Campbell, Susan L.; Robel, Stefanie; Holt, Kenneth T.; Ogunrinu-Babarinde, Toyin; Warren, Paula Province; White, David M.; Reid, Meredith A.; Eschbacher, Jenny M.; Berens, Michael E.; Lahti, Adrienne C.; Nabors, Louis B.; Sontheimer, Harald

2015-01-01

Glioma is the most common malignant primary brain tumor. Their rapid growth is aided by tumor-mediated release of glutamate, creating peritumoral excitotoxic cell death and vacating space for tumor expansion. Glioma glutamate release may also be responsible for seizures, which complicate the clinical course for many patients and are often the presenting symptom. A hypothesized glutamate release pathway is the cystine/glutamate transporter System xc− (SXC), responsible for the cellular synthesis of glutathione. However, the relationship of SXC-mediated glutamate release, seizures, and tumor growth remains unclear. Probing expression of SLC7A11/xCT, the catalytic subunit of SXC, in patient tissue and tissues propagated in mice, we found that approximately 50% of patient tumors have elevated SLC7A11 expression. Compared with tumors lacking this transporter, in vivo propagated and intracranially implanted SLC7A11-expressing tumors grew faster, produced pronounced peritumoral glutamate excitotoxicity, induced seizures, and shortened overall survival. In agreement with animal data, increased SLC7A11 expression predicted shorter patient survival according to annotated genomic data in the REMBRANDT database. In a clinical pilot study we used Magnetic Resonance Spectroscopy (MRS) to determine SXC-mediated glutamate release by measuring acute changes in glutamate after administration of the FDA-approved SXC inhibitor, sulfasalazine. In 9 glioma patients with biopsy-confirmed expression of SXC, we found that its expression positively correlates with glutamate release, which is acutely inhibited with oral sulfasalazine. These data suggest that SXC is the major pathway for glutamate release from gliomas and that SLC7A11 expression predicts accelerated growth and peritumoral seizures. PMID:26019222

14 CFR 1251.108 - Administrative requirements for small recipients.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Administrative requirements for small recipients. 1251.108 Section 1251.108 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NONDISCRIMINATION ON BASIS OF HANDICAP General Provisions § 1251.108 Administrative requirements for small...

14 CFR 1251.108 - Administrative requirements for small recipients.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Administrative requirements for small recipients. 1251.108 Section 1251.108 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NONDISCRIMINATION ON BASIS OF HANDICAP General Provisions § 1251.108 Administrative requirements for small...

14 CFR 1251.108 - Administrative requirements for small recipients.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Administrative requirements for small recipients. 1251.108 Section 1251.108 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NONDISCRIMINATION ON BASIS OF HANDICAP General Provisions § 1251.108 Administrative requirements for small...

14 CFR 1251.108 - Administrative requirements for small recipients.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Administrative requirements for small recipients. 1251.108 Section 1251.108 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NONDISCRIMINATION ON BASIS OF HANDICAP General Provisions § 1251.108 Administrative requirements for small...

78 FR 61398 - Notice of Intent To Grant Exclusive Research License

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-03

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 13-119] Notice of Intent To Grant Exclusive Research License AGENCY: National Aeronautics and Space Administration. ACTION: Notice of Intent to Grant... America as represented by the Administrator of the National Aeronautics and Space Administration. The...

The Challenge of Small Satellite Systems to the Space Security Environment

DTIC Science & Technology

2012-03-01

Space, 1945–1995, (New York: Dodd, Mead & Company, Inc. 1984), 142. 40 Moltz, The Politics of Space Security, 93. 41William E. Burrows , Deep Black...90 Stares, The Militarization of Space, 170. 91 Ibid. 92 Burrows , Deep Black, 279- 280. 30 to gather together in 1978 at the request...www.technologynewsroom.com/press_releases/company_releases.aspx?sto ry=522. Burrows , William E. Deep Black: Space Espionage and National Security

Endurance exercise modulates levodopa induced growth hormone release in patients with Parkinson's disease.

PubMed

Müller, Thomas; Welnic, Jacub; Woitalla, Dirk; Muhlack, Siegfried

2007-07-11

Acute levodopa (LD) application and exercise release human growth hormone (GH). An earlier trial showed, that combined stimulus of exercise and LD administration is the best provocative test for GH response in healthy participants. Objective was to show this combined effect of LD application and exercise on GH response and to investigate the impact on LD metabolism in 20 previously treated patients with Parkinson's disease (PD). We measured GH- and LD plasma concentrations following soluble 200 mg LD/50 mg benserazide administration during endurance exercise and rest on two separate consecutive days. GH concentrations significantly increased on both days, but GH release was significantly delayed during rest. LD metabolism was not altered due to exercise in a clinical relevant manner. Exercise induced a significant faster LD stimulated GH release in comparison with the rest condition. We did not find the supposed increase of LD induced GH release by endurance exercise. We assume, that only a limited amount of GH is available for GH release in the anterior pituitary following an acute 200 mg LD administration. GH disposal also depends on growth hormone releasing hormone (GHRH), which is secreted into hypothalamic portal capillaries. During the exercise condition, the resulting higher blood pressure supports blood flow and thus GHRH transport towards the GH producing cells in the pituitary. This might additionally have caused the significant faster GH release during exercise.

Experimental Studies of NaK in a Simulated Space Environment

NASA Technical Reports Server (NTRS)

Gibons, Marc; Sanzi, James; Ljubanovic, Damir

2011-01-01

Space fission power systems are being developed at the National Aeronautics and Space Administration (NASA) and Department of Energy (DOE) with a short term goal of building a full scale, non-nuclear, Technology Demonstration Unit (TDU) test at NASA's Glenn Research Center. Due to the geometric constraints, mass restrictions, and fairly high temperatures associated with space reactors, liquid metals are typically used as the primary coolant. A eutectic mixture of sodium (22 percent) and potassium (78 percent), or NaK, has been chosen as the coolant for the TDU with a total system capacity of approximately 55 L. NaK, like all alkali metals, is very reactive, and warrants certain safety considerations. To adequately examine the risk associated with the personnel, facility, and test hardware during a potential NaK leak in the large scale TDU test, a small scale experiment was performed in which NaK was released in a thermal vacuum chamber under controlled conditions. The study focused on detecting NaK leaks in the vacuum environment as well as the molecular flow of the NaK vapor. This paper reflects the work completed during the NaK experiment and provides results and discussion relative to the findings.

14 CFR 1245.115 - Action by the Administrator.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Action by the Administrator. 1245.115 Section 1245.115 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PATENTS AND OTHER INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.115 Action by the Administrator. (a) After...

14 CFR 1245.115 - Action by the Administrator.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Action by the Administrator. 1245.115 Section 1245.115 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PATENTS AND OTHER INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.115 Action by the Administrator. (a) After...

Electrospun formulations of bevacizumab for sustained release in the eye.

PubMed

Angkawinitwong, Ukrit; Awwad, Sahar; Khaw, Peng T; Brocchini, Steve; Williams, Gareth R

2017-12-01

Medicines based on vascular endothelial growth factor (VEGF) neutralising antibodies such as bevacizumab have revolutionized the treatment of age related macular degeneration (AMD), a common blinding disease, and have great potential in preventing scarring after surgery or accelerating the healing of corneal injuries. However, at present frequent invasive injections are required to deliver these antibodies. Such administration is uncomfortable for patients and expensive for health service providers. Much effort is thus focused on developing dosage forms that can be administered less frequently. Here we use electrospinning to prepare a solid form of bevacizumab designed for prolonged release while maintaining antibody stability. Electrospun fibers were prepared with bevacizumab encapsulated in the core, surrounded by a poly-ε-caprolactone sheath. The fibers were generated using aqueous bevacizumab solutions buffered at two different pH values: 6.2 (the pH of the commercial product; F beva ) and 8.3 (the isoelectric point of bevacizumab; F bevaP ). The fibers had smooth and cylindrical morphologies, with diameters of ca. 500nm. Both sets of bevacizumab loaded fibers gave sustained release profiles in an in vitro model of the subconjunctival space of the eye. F beva displayed first order kinetics with t 1/2 of 11.4±4.4 days, while F bevaP comprises a zero-order reservoir type release system with t 1/2 of 52.9±14.8 days. Both SDS-PAGE and surface plasmon resonance demonstrate that the bevacizumab in F bevaP did not undergo degradation during fiber fabrication or release. In contrast, the antibody released from F beva had degraded, and failed to bind to VEGF. Our results demonstrate that pH control is crucial to maintain antibody stability during the fabrication of core/shell fibers and ensure release of functional protein. Bevacizumab is a potent protein drug which is highly effective in the treatment of degenerative conditions in the eye. To be effective, frequent injections into the eye are required, which is deeply unpleasant for patients and expensive for healthcare providers. Alternative methods of administration are thus highly sought after. In our work, we use the electrospinning technique to prepare fiber-based formulations loaded with bevacizumab. By careful control of the experimental parameters we are able to stabilize the protein during processing and ensure a constant rate of release over more than two months in vitro. These fibers could thus be used to reduce the frequency of dosing required, reducing cost and improving patient outcomes. Copyright © 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

14 CFR § 1251.108 - Administrative requirements for small recipients.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Administrative requirements for small recipients. § 1251.108 Section § 1251.108 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NONDISCRIMINATION ON BASIS OF HANDICAP General Provisions § 1251.108 Administrative requirements...

Environmental analysis of the chemical release module. [space shuttle payload

NASA Technical Reports Server (NTRS)

Heppner, J. P.; Dubin, M.

1980-01-01

The environmental analysis of the Chemical Release Module (a free flying spacecraft deployed from the space shuttle to perform chemical release experiments) is reviewed. Considerations of possible effects of the injectants on human health, ionosphere, weather, ground based optical astronomical observations, and satellite operations are included. It is concluded that no deleterious environmental effects of widespread or long lasting nature are anticipated from chemical releases in the upper atmosphere of the type indicated for the program.

Benznidazole Extended-Release Tablets for Improved Treatment of Chagas Disease: Preclinical Pharmacokinetic Study

PubMed Central

Campos, Michel Leandro; Rosa, Talita Atanazio; Padilha, Elias Carvalho; Alzate, Alejandro Henao; Rolim, Larissa Araújo; Rolim-Neto, Pedro José

2016-01-01

Benznidazole (BNZ) is the first-line drug for the treatment of Chagas disease. The drug is available in the form of immediate-release tablets for 100-mg (adult) and 12.5-mg (pediatric) doses. The drug is administered two or three times daily for 60 days. The high frequency of daily administrations and the long period of treatment are factors that significantly contribute to the abandonment of therapy, affecting therapeutic success. Accordingly, this study aimed to evaluate the preclinical pharmacokinetics of BNZ administered as extended-release tablets (200-mg dose) formulated with different types of polymers (hydroxypropyl methylcellulose K4M and K100M), compared to the tablets currently available. The studies were conducted with rabbits, and BNZ quantification was performed in plasma and urine by ultraperformance liquid chromatography methods previously validated. The bioavailability of BNZ was adequate in the administration of extended-release tablets; however, with the administration of the pediatric tablet, the bioavailability was lower than with other tablets, which showed that the clinical use of this formulation should be monitored. The pharmacokinetic parameters demonstrated that the extended-release tablets prolonged drug release from the pharmaceutical matrix and provided an increase in the maintenance of the drug concentration in vivo, which would allow the frequency of administration to be reduced. Thus, a relative bioavailability study in humans will be planned for implementation of a new product for the treatment of Chagas disease. PMID:26883698

Understanding the drug release mechanism from a montmorillonite matrix and its binary mixture with a hydrophilic polymer using a compartmental modelling approach

NASA Astrophysics Data System (ADS)

Choiri, S.; Ainurofiq, A.

2018-03-01

Drug release from a montmorillonite (MMT) matrix is a complex mechanism controlled by swelling mechanism of MMT and an interaction of drug and MMT. The aim of this research was to explain a suitable model of the drug release mechanism from MMT and its binary mixture with a hydrophilic polymer in the controlled release formulation based on a compartmental modelling approach. Theophylline was used as a drug model and incorporated into MMT and a binary mixture with hydroxyl propyl methyl cellulose (HPMC) as a hydrophilic polymer, by a kneading method. The dissolution test was performed and the modelling of drug release was assisted by a WinSAAM software. A 2 model was purposed based on the swelling capability and basal spacing of MMT compartments. The model evaluation was carried out to goodness of fit and statistical parameters and models were validated by a cross-validation technique. The drug release from MMT matrix regulated by a burst release mechanism of unloaded drug, swelling ability, basal spacing of MMT compartment, and equilibrium between basal spacing and swelling compartments. Furthermore, the addition of HPMC in MMT system altered the presence of swelling compartment and equilibrium between swelling and basal spacing compartment systems. In addition, a hydrophilic polymer reduced the burst release mechanism of unloaded drug.

Environmental Impact Statement for the Cassini Mission. Supplement 1

NASA Technical Reports Server (NTRS)

1997-01-01

This Final Supplemental Environmental Impact Statement (FSEIS) to the 1995 Cassini mission Environmental Impact Statement (EIS) focuses on information recently made available from updated mission safety analyses. This information is pertinent to the consequence and risk analyses of potential accidents during the launch and cruise phases of the mission that were addressed in the EIS. The type of accidents evaluated are those which could potentially result in a release of plutonium dioxide from the three Radioisotope Thermoelectric Generators (RTGS) and the up to 129 Radioisotope Heater Units (RHUS) onboard the Cassini spacecraft. The RTGs use the heat of decay of plutonium dioxide to generate electric power for the spacecraft and instruments. The RHUs, each of which contains a small amount of plutonium dioxide, provide heat for controlling the thermal environment of the spacecraft and several of its instruments. The planned Cassini mission is an international cooperative effort of the National Aeronautics and Space Administration (NASA), the European Space Agency (ESA), and the Italian Space Agency (ASI) to conduct a 4-year scientific exploration of the planet Saturn, its atmosphere, moons, rings, and magnetosphere.

Mapping the pharmaceutical design space by amorphous ionic liquid strategies.

PubMed

Wiest, Johannes; Saedtler, Marco; Balk, Anja; Merget, Benjamin; Widmer, Toni; Bruhn, Heike; Raccuglia, Marc; Walid, Elbast; Picard, Franck; Stopper, Helga; Dekant, Wolfgang; Lühmann, Tessa; Sotriffer, Christoph; Galli, Bruno; Holzgrabe, Ulrike; Meinel, Lorenz

2017-12-28

Poor water solubility of drugs fuels complex formulations and jeopardizes patient access to medication. Simplifying these complexities we systematically synthesized a library of 36 sterically demanding counterions and mapped the pharmaceutical design space for amorphous ionic liquid strategies for Selurampanel, a poorly water soluble drug used against migraine. Patients would benefit from a rapid uptake after oral administration to alleviate migraine symptoms. Therefore, we probed the ionic liquids for the flux, supersaturation period and hygroscopicity leading to algorithms linking molecular counterion descriptors to predicted pharmaceutical outcome. By that, 30- or 800-fold improvements of the supersaturation period and fluxes were achieved as were immediate to sustained release profiles through structural counterions' optimization compared to the crystalline free acid of Selurampanel. Guided by ionic liquid structure, in vivo profiles ranged from rapid bioavailability and high maximal plasma concentrations to sustained patterns. In conclusion, the study outlined and predicted the accessible pharmaceutical design space of amorphous ionic liquid based and excipient-free formulations pointing to the enormous pharmaceutical potential of ionic liquid designs. Copyright © 2017 Elsevier B.V. All rights reserved.

Hormonal induction of gamete release, and in-vitro fertilisation, in the critically endangered Southern Corroboree Frog, Pseudophryne corroboree

PubMed Central

2010-01-01

Background Conservation Breeding Programs (CBP's) are playing an important role in the protection of critically endangered anuran amphibians, but for many species recruitment is not successful enough to maintain captive populations, or provide individuals for release. In response, there has been an increasing focus on the use of Assisted Reproductive Technologies (ART), including the administration of reproductive hormones to induce gamete release followed by in vitro fertilisation. The objective of this study was to test the efficacy of two exogenous hormones to induce gamete release, for the purpose of conducting in vitro fertilisation (IVF), in one of Australia's most critically endangered frog species, Pseudophryne corroboree. Methods Male frogs were administered a single dose of either human chorionic gonadotropin (hCG) or luteinizing hormone-releasing hormone (LHRHa), while female frogs received both a priming and ovulatory dose of LHRHa. Spermiation responses were evaluated at 3, 7, 12, 24, 36, 48, 60 and 72 h post hormone administration (PA), and sperm number and viability were quantified using fluorescent microscopy. Ovulation responses were evaluated by stripping females every 12 h PA for 5 days. Once gametes were obtained, IVF was attempted by combining spermic urine with oocytes in a dilute solution of simplified amphibian ringer (SAR). Results Administration of both hCG and LHRHa induced approximately 80% of males to release sperm over 72 h. Peak sperm release occurred at 12 h PA for hCG treated males and 36 h PA for LHRHa treated males. On average, LHRHa treated males released a significantly higher total number of live sperm, and a higher concentration of sperm, over a longer period. In female frogs, administration of LHRHa induced approximately 30% of individuals to release eggs. On average, eggs were released between 24 and 48 h PA, with a peak in egg release at 36 h PA. IVF resulted in a moderate percentage (54.72%) of eggs being fertilised, however all resultant embryos failed prior to gastrulation. Conclusions Hormone treatment successfully induced spermiation and ovulation in P. corroboree, but refinement of gamete induction and IVF techniques will be required before ART protocols can be used to routinely propagate this species. PMID:21114857

78 FR 25524 - Federal Aviation Administration

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-01

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Notice of Request To Release Airport Property AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Intent to Rule on Request to... address: Lynn D. Martin, Airports Compliance Specialist, Federal Aviation Administration, Airports...

75 FR 12809 - Federal Aviation Administration

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-17

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Notice of Intent To Rule on Request...: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Request to Release Airport Property. SUMMARY... Nicely, Manager, Federal Aviation Administration, Southwest Region, Airports Division, Texas Airports...

78 FR 16685 - Impax Laboratories, Inc.; Withdrawal of Approval of Bupropion Hydrochloride Extended-Release...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-18

...] Impax Laboratories, Inc.; Withdrawal of Approval of Bupropion Hydrochloride Extended-Release Tablets... Administration (FDA) is withdrawing approval of Bupropion Hydrochloride (HCl) Extended-Release Tablets, 300 Milligrams (mg) (Bupropion HCl Extended-Release Tablets 300 mg), under Abbreviated New Drug Application (ANDA...

77 FR 58438 - Notice of Request To Release Airport Property

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-20

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Notice of Request To Release Airport... Release Airport Property at the Meade Municipal Airport (MEJ), Meade, KS. SUMMARY: The FAA proposes to rule and invites public comment on the release of land at the Meade Municipal Airport (MEJ), Meade...

78 FR 16911 - Notice of Request To Release Airport Property

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-19

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Notice of Request To Release Airport... release airport property at the Ankeny Regional Airport, Ankeny, Iowa. SUMMARY: The FAA proposes to rule and invites public comment on the release of land at the Ankeny Regional Airport, Ankeny, Iowa, under...

Safer Aviation Materials Tested

NASA Technical Reports Server (NTRS)

Palaszewski, Bryan A.

2001-01-01

A series of thermally stable polymer samples were tested. These materials are called low heat release materials and are designed for aircraft interior decorative materials. The materials are designed to give off a minimum amount of noxious gases when heated, which increases the possibility that people can escape from a burning aircraft. New cabin materials have suitably low heat release so that fire does not spread, toxic chemicals are not given off, and the fire-emergency escape time for crew and passengers is lengthened. These low heat-release materials have a variety of advantages and applications: interiors for ground-based facilities, interiors of space vehicles, and many commercial fire-protection environments. A microscale combustion calorimeter at the Federal Aviation Administration's (FAA) Technical Center tested NASA Langley Research Center materials samples. The calorimeter is shown. A sharp, quantitative, and reproducible heat-release-rate peak is obtained in the microscale heat-release-rate test. The newly tested NASA materials significantly reduced the heat release capacity and total heat release. The thermal stability and flammability behavior of the samples was very good. The new materials demonstrated a factor of 4 reduction in total heat release over ULTEM (a currently used material). This information is provided in the following barchart. In other tests, the materials showed greater than a factor 9 reduction in heat-release capacity over ULTEM. The newly tested materials were developed for low dielectric constant, low color, and good solubility. A scale up of the material samples is needed to determine the repeatability of the performance in larger samples. Larger panels composed of the best candidate materials will be tested in a larger scale FAA Technical Center fire facility. The NASA Glenn Research Center, Langley (Jeff Hinkley), and the FAA Technical Center (Richard Lyon) cooperatively tested these materials for the Accident Mitigation aspects of Fire Prevention under NASA's Aviation Safety Program.

Incorporation of mRNA in Lamellar Lipid Matrices for Parenteral Administration.

PubMed

Ziller, Antje; Nogueira, Sara S; Hühn, Eva; Funari, Sergio S; Brezesinski, Gerald; Hartmann, Hermann; Sahin, Ugur; Haas, Heinrich; Langguth, Peter

2018-02-05

Insertion of high molecular weight messenger RNA (mRNA) into lyotropic lipid phases as model systems for controlled release formulations for the mRNA was investigated. Low fractions of 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) were used as an anchor to load the mRNA into a lamellar lipid matrix. Dispersions of zwitterionic lipid in the aqueous phase in the presence of increasing fractions of mRNA and cationic lipid were prepared, and the molecular organization was investigated as a function of mRNA and cationic lipid fraction. Insertion of both cationic lipid and mRNA was clearly proven from the physicochemical characteristics. The d-spacing of the lipid bilayers, as determined by small-angle X-ray scattering (SAXS) measurements, responded sensitively to the amount of inserted DOTAP and mRNA. A concise model of the insertion of the mRNA in the lipid matrices was derived, indicating that the mRNA was accommodated in the aqueous slab between lipid bilayers. Depending on the DOTAP and mRNA fraction, a different excess of water was present in this slab. Results from further physicochemical characterization, including determination of free and bound mRNA, zeta potential, and calorimetry data, were in line with this assumption. The structure of these concentrated lipid/mRNA preparations was maintained upon dilution. The functionality of the inserted mRNA was proven by cell culture experiments using C2C12 murine myoblast cells with the luciferase-encoding mRNA. The described lipid phases as carriers for the mRNA may be applicable for different routes of local administration, where control of the release kinetics and the form of the released mRNA (bound or free) is required.

Development of tolerance to the effects of vigabatrin (gamma-vinyl-GABA) on GABA release from rat cerebral cortex, spinal cord and retina.

PubMed Central

Neal, M. J.; Shah, M. A.

1990-01-01

1. The effects of acute and chronic vigabatrin (gamma-vinyl-GABA) (GVG) administration on gamma-aminobutyric acid (GABA) levels and release in rat cortical slices, spinal cord slices and retinas were studied. 2. GVG (250 mgkg-1 i.p.) administered to rats 18 h before death (acute administration) produced an almost 3 fold increase in GABA levels of the cortex and spinal cord and a 6 fold increase in retinal GABA. The levels of glutamate, aspartate, glycine and taurine were unaffected. 3. When GVG (250 mgkg-1 i.p.) was administered daily for 17 days (chronic administration) a similar (almost 3 fold) increase in cortical GABA occurred but the increases in spinal and retinal GABA were reduced by approximately 40%. 4. Acute administration of GVG strikingly increased the potassium-evoked release (KCl 50 mM) of GABA from all three tissues. This enhanced evoked release was reduced by about 50% in tissues taken from rats that had been chronically treated with GVG. 5. Acute administration of GVG reduced GABA-transaminase (GABA-T) activity by approximately 80% in cortex and cord and by 98% in the retina. Following the chronic administration of GVG, there was a trend for GABA-T activities to recover (significant only in cortex). Acute administration of GVG had no effect on glutamic acid decarboxylase (GAD) activity in cortex or spinal cord. However, chronic treatment resulted in significant decreases in GAD activity in both the cortex and cord (35% and 50% reduction respectively).(ABSTRACT TRUNCATED AT 250 WORDS) PMID:2379037

Return to Flight Task Group

NASA Technical Reports Server (NTRS)

2005-01-01

It has been 29 months since Columbia was lost over East Texas in February 2003. Seven months after the accident, the Columbia Accident Investigation Board (CAIB) released the first volume of its final report, citing a variety of technical, managerial, and cultural issues within NASA and the Space Shuttle Program. To their credit, NASA offered few excuses, embraced the report, and set about correcting the deficiencies noted by the accident board. Of the 29 recommendations issued by the CAIB, 15 were deemed critical enough that the accident board believed they should be implemented prior to returning the Space Shuttle to flight. Some of these recommendations were relatively easy, most were straightforward, a few bordered on the impossible, and others were largely overcome by events, particularly the decision by the President to retire the Space Shuttle by 2010. The Return to Flight Task Group (RTF TG, or simply, the Task Group) was chartered by the NASA Administrator in July 2003 to provide an independent assessment of the implementation of the 15 CAIB return-to-flight recommendations. An important observation must be stated up-front: neither the CAIB nor the RTF TG believes that all risk can be eliminated from Space Shuttle operations; nor do we believe that the Space Shuttle is inherently unsafe. What the CAIB and RTF TG do believe, however, is that NASA and the American public need to understand the risks associated with space travel, and that NASA must make every reasonable effort to minimize such risk. Since the release of the CAIB report, NASA and the Space Shuttle Program expended enormous effort and resources toward correcting the causes of the accident and preparing to fly again. Relative to the 15 specific recommendations that the CAIB indicated should be implemented prior to returning to flight, NASA has met or exceeded most of them the Task Group believes that NASA met the intent of the CAIB for 12 of these recommendations. The remaining three recommendations were so challenging that NASA could not comply completely with the intent of the CAIB.

78 FR 1265 - Aerospace Safety Advisory Panel; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-08

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 13-001] Aerospace Safety Advisory Panel... Aeronautics and Space Administration announces a forthcoming meeting of the Aerospace Safety Advisory Panel..., Aerospace Safety Advisory Panel Executive Director, National Aeronautics and Space Administration...

76 FR 62455 - Aerospace Safety Advisory Panel; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-07

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (11-088)] Aerospace Safety Advisory Panel... Aeronautics and Space Administration announces a forthcoming meeting of the Aerospace Safety Advisory Panel... Burch, Aerospace Safety Advisory Panel Administrative Officer, National Aeronautics and Space...

75 FR 75702 - Notice of Information Collection

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-06

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [10-152] Notice of Information Collection AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of information collection. SUMMARY: The National Aeronautics and Space Administration, as part of its continuing effort to reduce...

Dopamine release in rat striatum - Physiological coupling to tyrosine supply

NASA Technical Reports Server (NTRS)

During, Matthew J.; Acworth, Ian N.; Wurtman, Richard J.

1989-01-01

Intracerebral microdialysis was used to monitor dopamine release in rat striatal extracellular fluid following the intraperitoneal administration of dopamine's precursor amino acid, L-tyrosine. Dopamine concentrations in dialysates increased transiently after tyrosine (50-100 mg/kg) administration. Pretreatment with haloperidol or the partial lesioning of nigrostriatal neurons enhanced the effect of tyrosine on dopamine release, and haloperidol also prolonged this effect. These data suggest that nigrostriatal dopaminergic neurons are responsive to changes in precursor availability under basal conditions, but that receptor-mediated feedback mechanisms limit the magnitude and duration of this effect.

KSC-02pd1858

NASA Image and Video Library

2002-12-05

KENNEDY SPACE CENTER, FLA. - Stephen Ezell, meteorological systems operator at Weather Station A, Cape Canaveral Air Force Station, gets ready to release a weather balloon. Such balloons are released twice a day. The package in Ezell's hand is a radio sonde that collects temperature and humidity data as the balloon rises. The data is released to agencies nationwide, including the 45th Space Wing, which uses the data for its daily weather reports. The weather station provides additional data to NASA for launches -- releasing 12 balloons in eight hours prior to liftoff - and landings - releasing 5 balloons in six and a half hours before expected touchdown.

KSC-02pd1859

NASA Image and Video Library

2002-12-05

KENNEDY SPACE CENTER, FLA. -- Stephen Ezell, meteorological systems operator at Weather Station A, Cape Canaveral Air Force Station, releases a weather balloon. Such balloons are released twice a day. The package at the bottom is a radio sonde that collects temperature and humidity data as the balloon rises. The data is released to agencies nationwide, including the 45th Space Wing, which uses the data for its daily weather reports. The weather station provides additional data to NASA for launches -- releasing 12 balloons in eight hours prior to liftoff - and landings - releasing 5 balloons in six and a half hours before expected touchdown.

KSC-02pd1857

NASA Image and Video Library

2002-12-05

KENNEDY SPACE CENTER, FLA. - Stephen Ezell, meteorological systems operator at Weather Station A, Cape Canaveral Air Force Station, gets ready to release a weather balloon. Such balloons are released twice a day. The package in Ezell's hand is a radio sonde that collects temperature and humidity data as the balloon rises. The data is released to agencies nationwide, including the 45th Space Wing, which uses the data for its daily weather reports. The weather station provides additional data to NASA for launches -- releasing 12 balloons in eight hours prior to liftoff - and landings - releasing 5 balloons in six and a half hours before expected touchdown.

7 CFR 1.15 - General provisions respecting release of records.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 1 2013-01-01 2013-01-01 false General provisions respecting release of records. 1.15 Section 1.15 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Official Records § 1.15 General provisions respecting release of records. (a) When releasing documents, agencies...

21 CFR 181.28 - Release agents.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Release agents. Substances classified as release agents, when migrating from food-packaging material shall... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Release agents. 181.28 Section 181.28 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...

21 CFR 181.28 - Release agents.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Release agents. 181.28 Section 181.28 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... Release agents. Substances classified as release agents, when migrating from food-packaging material shall...

21 CFR 181.28 - Release agents.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Release agents. Substances classified as release agents, when migrating from food-packaging material shall... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Release agents. 181.28 Section 181.28 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...

21 CFR 181.28 - Release agents.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Release agents. Substances classified as release agents, when migrating from food-packaging material shall... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Release agents. 181.28 Section 181.28 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...

48 CFR 1404.804-70 - Release of claims.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ADMINISTRATIVE MATTERS Contract Files 1404.804-70 Release of claims. (a) The CO shall insert the clause at 1452.204-70, Release of Claims, in all construction, architect and engineering, and cost-reimbursement... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Release of claims. 1404...

48 CFR 1404.804-70 - Release of claims.

Code of Federal Regulations, 2013 CFR

2013-10-01

... ADMINISTRATIVE MATTERS Contract Files 1404.804-70 Release of claims. (a) The CO shall insert the clause at 1452.204-70, Release of Claims, in all construction, architect and engineering, and cost-reimbursement... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Release of claims. 1404...

48 CFR 1404.804-70 - Release of claims.

Code of Federal Regulations, 2014 CFR

2014-10-01

... ADMINISTRATIVE MATTERS Contract Files 1404.804-70 Release of claims. (a) The CO shall insert the clause at 1452.204-70, Release of Claims, in all construction, architect and engineering, and cost-reimbursement... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Release of claims. 1404...

48 CFR 1404.804-70 - Release of claims.

Code of Federal Regulations, 2011 CFR

2011-10-01

... ADMINISTRATIVE MATTERS Contract Files 1404.804-70 Release of claims. (a) The CO shall insert the clause at 1452.204-70, Release of Claims, in all construction, architect and engineering, and cost-reimbursement... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Release of claims. 1404...

48 CFR 1404.804-70 - Release of claims.

Code of Federal Regulations, 2012 CFR

2012-10-01

... ADMINISTRATIVE MATTERS Contract Files 1404.804-70 Release of claims. (a) The CO shall insert the clause at 1452.204-70, Release of Claims, in all construction, architect and engineering, and cost-reimbursement... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Release of claims. 1404...

78 FR 9770 - Notice of Request to Release Airport Property

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-11

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Notice of Request to Release Airport... Release Airport Property at the Colonel James Jabara Airport (AAO), Wichita, KS. SUMMARY: The FAA proposes to rule and invites public comment on the release of land at the Colonel James Jabara Airport (AAO...

5 CFR 351.603 - Actions subsequent to release from competitive level.

Code of Federal Regulations, 2010 CFR

2010-01-01

... competitive level. 351.603 Section 351.603 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS REDUCTION IN FORCE Release From Competitive Level § 351.603 Actions subsequent to release from competitive level. An employee reached for release from a competitive level shall be offered...

5 CFR 351.603 - Actions subsequent to release from competitive level.

Code of Federal Regulations, 2011 CFR

2011-01-01

... competitive level. 351.603 Section 351.603 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS REDUCTION IN FORCE Release From Competitive Level § 351.603 Actions subsequent to release from competitive level. An employee reached for release from a competitive level shall be offered...

SRTM Data Release for Africa, Colored Height

NASA Technical Reports Server (NTRS)

2004-01-01

This color shaded relief image shows the extent of digital elevation data for Africa recently released by the Shuttle Radar Topography Mission (SRTM). This release includes data for all of the continent, plus the island of Madagascar and the Arabian Peninsula. SRTM flew on board the Space Shuttle Endeavour in February 2000 and used an interferometric radar system to map the topography of Earth's landmass between latitudes 56 degrees south and 60 degrees north.

The data were processed into geographic 'tiles,' each of which represents one by one degree of latitude and longitude. A degree of latitude measures 111 kilometers (69 miles) north-south, and a degree of longitude measures 111 kilometers or less east-west, decreasing away from the equator. The data are being released to the public on a continent-by-continent basis. This Africa segment includes 3256 tiles, almost a quarter of the total data set. Previous releases covered North America, South America and Eurasia. Forthcoming releases will include Australia plus an 'Islands' release for those islands not included in the continental releases. Together these data releases constitute the world's first high-resolution, near-global elevation model. The resolution of the publicly released data is three arcseconds (1/1,200 of a degree of latitude and longitude), which is about 90 meters (295 feet).

Coverage in the current data release extends from 35 degrees north latitude at the southern edge of the Mediterranean to the very tip of South Africa, encompassing a great diversity of landforms. The northern part of the continent consists of a system of basins and plateaus, with several volcanic uplands whose uplift has been matched by subsidence in the large surrounding basins. Many of these basins have been infilled with sand and gravel, creating the vast Saharan lands. The Atlas Mountains in the northwest were created by convergence of the African and Eurasian tectonic plates.

The geography of the central latitudes of Africa is dominated by the Great Rift Valley, extending from Lake Nyasa to the Red Sea, and splitting into two arms to enclose an interior plateau and the nearly circular Lake Victoria, visible in the right center of the image. To the west lies the Congo Basin, a vast, shallow depression which rises to form an almost circular rim of highlands.

Most of the southern part of the continent rests on a concave plateau comprising the Kalahari basin and a mountainous fringe, skirted by a coastal plain which widens out in Mozambique in the southeast.

Many of these regions were previously very poorly mapped due to persistent cloud cover or the inaccessibility of the terrain. Digital elevation data, such as provided by SRTM, are particularly in high demand by scientists studying earthquakes, volcanism, and erosion patterns for use in mapping and modeling hazards to human habitation. But the shape of Earth's surface affects nearly every natural process and human endeavor that occurs there, so elevation data are used in a wide range of applications.

In this index map color-coding is directly related to topographic height, with brown and yellow at the lower elevations, rising through green, to white at the highest elevations. Blue areas on the map represent water within the mapped tiles, each of which includes shorelines or islands.

Elevation data used in this image were acquired by the Shuttle Radar Topography Mission (SRTM) aboard the Space Shuttle Endeavour, launched on February 11, 2000. SRTM used the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) that flew twice on the Space Shuttle Endeavour in 1994. SRTM was designed to collect three-dimensional measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter-long (200-foot) mast, installed additional C-band and X-band antennas, and improved tracking and navigation devices. The mission is a cooperative project between the National Aeronautics and Space Administration (NASA), the National Geospatial-Intelligence Agency (NGA) of the U.S. Department of Defense (DoD), and the German and Italian space agencies. It is managed by NASA's Jet Propulsion Laboratory, Pasadena, Calif., for NASA's Earth Science Enterprise, Washington, DC.

Orientation: North toward the top, Mercator projection Image Data: Colored SRTM elevation model Date Acquired: February 2000

SRTM Data Release for Eurasia, Index Map and Colored Height

NASA Technical Reports Server (NTRS)

2004-01-01

The colored regions of this map show the extent of digital elevation data recently released by the Shuttle Radar Topography Mission (SRTM). This release includes data for most of Europe and Asia plus numerous islands in the Indian and Pacific Oceans. SRTM flew on board the Space Shuttle Endeavour in February 2000 and used an interferometric radar system to map the topography of Earth's landmass between latitudes 56 degrees south and 60 degrees north.

The data were processed into geographic 'tiles,' each of which represents one by one degree of latitude and longitude. A degree of latitude measures 111 kilometers (69 miles) north-south, and a degree of longitude measures 111 kilometers or less east-west, decreasing away from the equator. The data are being released to the public on a continent-by-continent basis. This Eurasia segment includes 5,940 tiles, more than a third of the total data set. Previous releases covered North America and South America. Forthcoming releases will include Africa-Arabia and Australia plus an 'Islands' release for those islands not included in the continental releases. Together these data releases constitute the world's first high-resolution, near-global elevation model. The resolution of the publicly released data is three arcseconds (1/1,200 of a degree of latitude and longitude), which is about 90 meters (295 feet).

European coverage in the current data release stretches eastward from the British Isles and the Iberian Peninsula in the west, across the Alps and Carpathian Mountains, as well as the Northern European Plain, to the Ural and Caucasus Mountains bordering Asia. The Asian coverage includes a great diversity of landforms, including the Tibetan Plateau, Tarin Basin, Mongolian Plateau, and the mountains surrounding Lake Baikal, the world's deepest lake. Mt. Everest in the Himalayas, at 8,848 meters (29,029 feet) is the world's highest mountain. From India's Deccan Plateau, to Southeast Asia, coastal China, and Korea, various landforms place constraints upon land use planning for a great population. Volcanoes in the East Indies, the Philippines, Japan, and the Kamchatka Peninsula form the western part of the 'Ring of Fire' around the Pacific Ocean.

Many of these regions were previously very poorly mapped due to persistent cloud cover or the inaccessibility of the terrain. Digital elevation data, such as provided by SRTM, are particularly in high demand by scientists studying earthquakes, volcanism, and erosion patterns for use in mapping and modeling hazards to human habitation. But the shape of Earth's surface affects nearly every natural process and human endeavor that occurs there, so elevation data are used in a wide range of applications.

In this index map color-coding is directly related to topographic height, with green at the lower elevations, rising through yellow and tan, to white at the highest elevations. The large, very dark green feature in western Asia is the Caspian Sea, which is below sea level. Blue areas on the map represent water within the mapped tiles, each of which includes shorelines or islands.

Elevation data used in this image was acquired by the Shuttle Radar Topography Mission (SRTM) aboard the Space Shuttle Endeavour, launched on February 11, 2000. SRTM used the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) that flew twice on the Space Shuttle Endeavour in 1994. SRTM was designed to collect three-dimensional measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter-long (200-foot) mast, installed additional C-band and X-band antennas, and improved tracking and navigation devices. The mission is a cooperative project between the National Aeronautics and Space Administration (NASA), the National Geospatial-Intelligence Agency (NGA) of the U.S. Department of Defense (DoD), and the German and Italian space agencies. It is managed by NASA's Jet Propulsion Laboratory, Pasadena, CA, for NASA's Earth Science Enterprise, Washington, DC.

Orientation: North toward the top Image Data: Colored SRTM elevation model Date Acquired: February 2000

Acetylcholine released from cholinergic nerves contributes to cutaneous vasodilation during heat stress

NASA Technical Reports Server (NTRS)

Shibasaki, Manabu; Wilson, Thad E.; Cui, Jian; Crandall, Craig G.

2002-01-01

Nitric oxide (NO) contributes to active cutaneous vasodilation during a heat stress in humans. Given that acetylcholine is released from cholinergic nerves during whole body heating, coupled with evidence that acetylcholine causes vasodilation via NO mechanisms, it is possible that release of acetylcholine in the dermal space contributes to cutaneous vasodilation during a heat stress. To test this hypothesis, in seven subjects skin blood flow (SkBF) and sweat rate were simultaneously monitored over three microdialysis membranes placed in the dermal space of dorsal forearm skin. One membrane was perfused with the acetylcholinesterase inhibitor neostigmine (10 microM), the second membrane was perfused with the NO synthase inhibitor N(G)-nitro-l-arginine methyl ester (l-NAME; 10 mM) dissolved in the aforementioned neostigmine solution (l-NAME(Neo)), and the third membrane was perfused with Ringer solution as a control site. Each subject was exposed to approximately 20 min of whole body heating via a water-perfused suit, which increased mean body temperature from 36.4 +/- 0.1 to 37.5 +/- 0.1 degrees C (P < 0.05). After the heat stress, SkBF at each site was normalized to its maximum value, identified by administration of 28 mM sodium nitroprusside. Mean body temperature threshold for cutaneous vasodilation was significantly lower at the neostigmine-treated site relative to the other sites (neostigmine: 36.6 +/- 0.1 degrees C, l-NAME(Neo): 37.1 +/- 0.1 degrees C, control: 36.9 +/- 0.1 degrees C), whereas no significant threshold difference was observed between the l-NAME(Neo)-treated and control sites. At the end of the heat stress, SkBF was not different between the neostigmine-treated and control sites, whereas SkBF at the l-NAME(Neo)-treated site was significantly lower than the other sites. These results suggest that acetylcholine released from cholinergic nerves is capable of modulating cutaneous vasodilation via NO synthase mechanisms early in the heat stress but not after substantial cutaneous vasodilation.

The Pan-STARRS1 Survey Data Release

NASA Astrophysics Data System (ADS)

Chambers, Kenneth C.; Pan-STARRS Team

2017-01-01

The first Pan-STARRS1 Science Mission is complete and an initial Data Release 1, or DR1, including a database of measured attributes, stacked images, and metadata of the 3PI Survey, will be available from the STScI MAST archive. This release will contain all stationary objects with mean and stack photometry registered on the GAIA astrometric frame.The characteristics of the Pan-STARRS1 Surveys will be presented, including image quality, depth, cadence, and coverage. Measured attributes include PSF model magnitudes, aperture magnitudes, Kron Magnitudes, radial moments, Petrosian magnitudes, DeVaucoulers, Exponential, and Sersic magnitudes for extended objects. Images include total intensity, variance, and masks.An overview of both DR1 and the second data release DR2, to follow in the spring of 2017, will be presented. DR2 will add all time domain data and individual warped images. We will also report on the status of the Pan-STARRS2 Observatory and ongoing science with Pan-STARRS. The science from the PS1 surveys has included results in many t fields of astronomy from Near Earth Objects to cosmology.The Pan-STARRS1 Surveys have been made possible through contributions of the Institute for Astronomy of the University of Hawaii; the Pan-STARRS Project Office; the Max-Planck Society and its participating institutes: the Max Planck Institute for Astronomy, Heidelberg and the Max Planck Institute for Extraterrestrial Physics, Garching; The Johns Hopkins University; Durham University; the University of Edinburgh; Queen's University Belfast; the Harvard-Smithsonian Center for Astrophysics, the Las Cumbres Observatory Global Telescope Network Incorporated; the National Central University of Taiwan; the Space Telescope Science Institute; the National Aeronautics and Space Administration under Grants No. NNX08AR22G, NNX12AR65G, NNX14AM74G issued through the Planetary Science Division of the NASA Science Mission Directorate; the National Science Foundation under Grant No. AST-1238877; the University of Maryland; the Eotvos Lorand University; and the Los Alamos National Laboratory.

46 CFR 108.457 - Pressure release.

Code of Federal Regulations, 2010 CFR

2010-10-01

.... Each air tight or vapor tight space, such as a paint locker, that is protected by a CO2 system must have a means for releasing pressure that accumulates within the space if CO2 is discharged into the...

Dragon Spacecraft grappled by SSRMS

NASA Image and Video Library

2014-04-20

View of the SpaceX Dragon Commercial Resupply Services-3 (CRS-3) spacecraft grappled by the Canadarm2 Space Station Remote Manipulator System (SSRMS) during Expedition 39. Image was released by released by flight engineer 3 (FE3) on Instagram.

Thermosensitive liposomes: extravasation and release of contents in tumor microvascular networks.

PubMed

Gaber, M H; Wu, N Z; Hong, K; Huang, S K; Dewhirst, M W; Papahadjopoulos, D

1996-12-01

The purpose of this study was to determine whether hyperthermic exposure would accelerate drug release from thermosensitive sterically stabilized liposomes and enhance their extravasation in tumor tissues. In vivo fluorescence video microscopy was used to measure the extravasation of liposomes, as well as release of their contents, in a rat skin flap window chamber containing a vascularized mammary adenocarcinoma under defined thermal conditions (34 degrees, 42 degrees, and 45 degrees C). Images of tissue areas containing multiple blood vessels were recorded via a SIT camera immediately before, and for up to 2 h after i.v. injection of two liposome populations with identical lipid composition: one liposome preparation was surface labeled with Rhodamine-PE (Rh-PE) and the other contained either Doxorubicin (Dox) or calcein at self-quenching concentrations. The light intensity of the entire tissue area was measured at 34 degrees C (the physiological temperature of the skin) for 1 h, and at 42 degrees or 45 degrees C for a second hour. These measurements were then used to calculate the fluorescent light intensity arising from each tracer (liposome surface label and the released contents) inside the vessel and in the interstitial region. The calculated intensity of Rh-PE for the thermosensitive liposomes in the interstitial space (which represents the amount of extravasated liposomes) was low during the first hour, while temperature was maintained at 34 degrees C and increased to 47 times its level before heating, when the tumor was heated at 42 degrees or 45 degrees C for 1 h. The calculated intensity of the liposome contents (Dox) in the interstitial space was negligible at 34 degrees C, and increased by 38- and 76-fold, when the tumor was heated at 42 degrees and 45 degrees C for 1 h, respectively. Similar values were obtained when calcein was encapsulated in liposomes instead of Dox. A similar increase in liposome extravasation was seen with nonthermosensitive liposomes, but negligible release of Dox occurred when the window chamber was heated to 45 degrees C for 1 h. Extravasation of liposomes continued after heating was stopped, but content release stopped after removal of heat. Release of Dox from extravasated liposomes was also seen if heating was applied 24 h after liposome administration, but no further enhancement of liposome extravasation occurred in this case. Our data suggest that hyperthermia can be used to selectively enhance both the delivery and the rate of release of drugs from thermosensitive liposomes to targeted tissues.

Oral administration of arginine enhances the growth hormone response to growth hormone releasing hormone in short children.

PubMed

Loche, S; Carta, D; Muntoni, A C; Corda, R; Pintor, C

1993-10-01

We have evaluated the effect of oral administration of arginine chlorhydrate on the growth hormone response to growth hormone releasing hormone in a group of nine short prepubertal children (six boys and four girls). Arginine chlorhydrate 10 g, administered orally 60 min before an i.v. bolus injection of growth hormone releasing hormone 1-29, 1 microgram/kg, significantly enhanced the growth hormone response to the neuropeptide, confirming the results of previous studies which used the i.v. route. Furthermore, our data strengthen the view that the effects of arginine chlorhydrate on growth hormone secretion are mediated by inhibition of endogenous somatostatin release.

76 FR 36937 - Aerospace Safety Advisory Panel; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-23

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2012-01-12

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75 FR 61219 - Aerospace Safety Advisory Panel; Meeting

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2010-10-04

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2010-06-28

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2012-04-30

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75 FR 65669 - Notice of Information Collection

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2010-10-26

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2010-02-09

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2011-04-26

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2011-01-18

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2011-09-09

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78 FR 15976 - Aerospace Safety Advisory Panel; Meeting.

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2013-03-13

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2010-04-15

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2010-10-26

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75 FR 59747 - NASA Advisory Council; Meeting.

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2010-09-28

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2010-05-19

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2012-07-03

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2011-12-21

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2010-10-08

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2010-10-06

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (10-119)] Notice of Information Collection AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of information collection. SUMMARY: The National Aeronautics and Space Administration, as part of its continuing effort to reduce...

RIP1-mediated mitochondrial dysfunction and ROS production contributed to tumor necrosis factor alpha-induced L929 cell necroptosis and autophagy.

PubMed

Ye, Yuan-Chao; Wang, Hong-Ju; Yu, Lu; Tashiro, Shin-Ichi; Onodera, Satoshi; Ikejima, Takashi

2012-12-01

Tumor necrosis factor alpha (TNFα) induces necroptosis and autophagy; however, the detailed molecular mechanism is not fully understood. In this study, we found that TNFα administration caused mitochondrial dysfunction and reactive oxygen species (ROS) production, which led to necroptosis and autophagy in murine fibrosarcoma L929 cells. Notably, the RIP1 (serine-threonine kinase receptor-interacting protein 1, a main adaptor protein of necroptosis) specific inhibitor necrostatin-1 (Nec-1) recovered mitochondrial dysfunction and ROS production due to TNFα administration. Moreover, pan-caspase inhibitor z-VAD-fmk (zVAD) increased RIP1 expression and exacerbated TNFα-induced mitochondrial dysfunction and ROS production, indicating that RIP1 led to mitochondrial dysfunction and ROS production. In addition, cytochrome c release from mitochondria was accompanied with TNFα administration, and Nec-1 blocked the release of cytochrome c upon TNFα administration, while zVAD enhanced the release. These further suggested that RIP1 induced mitochondrial dysfunction accompanied with cytochrome c release. Furthermore, autophagy inhibitor 3-methyladenine (3MA) did not affect RIP1 expression as well as mitochondrial dysfunction and ROS production. Together with our previous publication that autophagy was a downstream consequence of necroptosis, we concluded that TNFα induced mitochondrial dysfunction accompanied with ROS production and cytochrome c release via RIP1, leading to necroptosis and resulting autophagic cell death. Copyright © 2012 Elsevier B.V. All rights reserved.

28 CFR 50.2 - Release of information by personnel of the Department of Justice relating to criminal and civil...

Code of Federal Regulations, 2010 CFR

2010-07-01

... representative of the Department believes that in the interest of the fair administration of justice and the law... the Department of Justice relating to criminal and civil proceedings. 50.2 Section 50.2 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) STATEMENTS OF POLICY § 50.2 Release of information by personnel...

78 FR 13905 - Government-Owned Inventions, Available for Licensing

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2013-03-01

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2013-09-19

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2010-09-08

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2012-09-06

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75 FR 61778 - NASA Advisory Council; Science Committee; Astrophysics Subcommittee; Meeting

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2010-10-06

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2012-10-09

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76 FR 26316 - Aerospace Safety Advisory Panel; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-06

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2013-04-02

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76 FR 21072 - NASA Advisory Council; Meeting

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2011-04-14

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2013-03-01

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76 FR 63663 - NASA Advisory Council; Human Exploration and Operations Committee; Meeting

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2011-10-13

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75 FR 4589 - NASA Advisory Council Exploration Committee Meeting

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2010-01-28

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In vitro biorelevant models for evaluating modified release mesalamine products to forecast the effect of formulation and meal intake on drug release.

PubMed

Andreas, Cord J; Chen, Ying-Chen; Markopoulos, Constantinos; Reppas, Christos; Dressman, Jennifer

2015-11-01

Postprandial administration of solid oral dosage forms greatly changes the dissolution environment compared to fasted state administration. The aims of this study were to investigate and forecast the effect of co-administration of a meal on drug release for delayed and/or extended release mesalamine formulations as well as design of in vitro tests to distinguish among formulations in a biorelevant way. Five different mesalamine formulations (Asacol® 400 mg, Mezavant® 1200 mg, Pentasa® 500 mg and Salofalk® in the 250 mg and 500 mg strengths) were investigated with biorelevant dissolution methods using the USP apparatus III and USP apparatus IV (open loop mode) under both fasted and fed state conditions, as well as with the dissolution methods described in pharmacopeia for delayed and extended release mesalamine products. Using the biorelevant experimental conditions proposed in this study, changes in release in the proximal gut due to meal intake are forecast to be minimal for Asacol®, Mezavant®, Pentasa® and Salofalk® 500 mg, while for Salofalk® 250 mg release was predicted to occur much earlier under fed state conditions. The USP apparatus III generally tended to result in faster dissolution rates and forecast more pronounced food effects for Salofalk® 250 mg than the USP apparatus IV. The biorelevant dissolution gradients were also able to reflect the in vivo behavior of the formulations. In vitro biorelevant models can be useful in the comparison of the release behavior from different delayed and extended release mesalamine formulations as well as forecasting effects of concomitant meal intake on drug release. Copyright © 2015 Elsevier B.V. All rights reserved.

NASA Unveils Celestial Fireworks as Official Image for Hubble 25th Anniversary

NASA Image and Video Library

2015-04-23

The brilliant tapestry of young stars flaring to life resemble a glittering fireworks display in the 25th anniversary NASA Hubble Space Telescope image, released to commemorate a quarter century of exploring the solar system and beyond since its launch on April 24, 1990. “Hubble has completely transformed our view of the universe, revealing the true beauty and richness of the cosmos” said John Grunsfeld, astronaut and associate administrator of NASA’s Science Mission Directorate. “This vista of starry fireworks and glowing gas is a fitting image for our celebration of 25 years of amazing Hubble science.” The sparkling centerpiece of Hubble’s anniversary fireworks is a giant cluster of about 3,000 stars called Westerlund 2, named for Swedish astronomer Bengt Westerlund who discovered the grouping in the 1960s. The cluster resides in a raucous stellar breeding ground known as Gum 29, located 20,000 light-years away from Earth in the constellation Carina. Read more: www.nasa.gov/press-release/nasa-unveils-celestial-firewor... NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Delivery of DNA vaccines by agarose hydrogel implants facilitates genetic immunization in cattle.

PubMed

Toussaint, J F; Dubois, A; Dispas, M; Paquet, D; Letellier, C; Kerkhofs, P

2007-01-26

The present study demonstrates the interest of two slow-release systems as vaccination tools in cattle. Two experiments show that a first intradermal administration of one DNA vaccine dose combined with the slow-release of a second dose conduct to a priming of the bovine herpesvirus 1-specific immune response similar to the one generated by two discrete administrations 4 weeks apart. The first experiment demonstrates the efficacy of the slow-release system with well-characterized Alzet osmotic pumps, whereas the second experiment extends the same concept with innovative agarose hydrogel implants. These latter implants are cheaper and more convenient than the osmotic pumps or repeated intradermal administrations since they contribute to an efficient priming of the immune response in a single manipulation of the animals.

Modeling the pharmacokinetics of extended release pharmaceutical systems

NASA Astrophysics Data System (ADS)

di Muria, Michela; Lamberti, Gaetano; Titomanlio, Giuseppe

2009-03-01

The pharmacokinetic (PK) models predict the hematic concentration of drugs after the administration. In compartment modeling, the body is described by a set of interconnected “vessels” or “compartments”; the modeling consisting of transient mass balances. Usually the orally administered drugs were considered as immediately available: this cannot describe the administration of extended-release systems. In this work we added to the traditional compartment models the ability to account for a delay in administration, relating this delay to in vitro data. Firstly, the method was validated, applying the model to the dosage of nicotine by chewing-gum; the model was tuned by in vitro/in vivo data of drugs (divalproex-sodium and diltiazem) with medium-rate release kinetics, then it was applied in describing in vivo evolutions due to the assumption of fast- and slow-release systems. The model reveals itself predictive, the same of a Level A in vitro/in vivo correlation, but being physically based, it is preferable to a purely statistical method.

Development of near zero-order release PLGA-based microspheres of a novel antipsychotic.

PubMed

Zhao, Jinlong; Wang, Lexi; Fan, Chunyu; Yu, Kongtong; Liu, Ximing; Zhao, Xiaolei; Wang, Dan; Liu, Wenhua; Su, Zhengxing; Sun, Fengying; Li, Youxin

2017-01-10

The novel antipsychotic isoperidone, a prodrug of paliperidone, was designed to improve liposolubility for the development of poly(D,L-lactide-co-glycolide) (PLGA)-based microspheres to achieve near zero-order release behaviour in vivo. Microspheres with a smooth surface were obtained using the oil-in-water emulsion solvent evaporation method and yielded a high encapsulation efficiency of 92%. Pharmacokinetic studies in beagle dogs showed a one-week plateau phase followed by a two-week quasi-zero-order release with no burst release. The in vitro release method with a good in vitro-in vivo correlation was also established. Pharmacodynamic evaluation was performed using the MK-801-induced schizophrenic behavioural mouse model, and the sustained suppressive effect lasted two weeks. The pharmacokinetic-pharmacodynamic (PK-PD) relationship of isoperidone microspheres was compared to that of oral administration of free drug. The results revealed a strong correlation between the plasma drug level and the antipsychotic effect. A stable drug plasma concentration was detected in mice both intraday and interday from 8 to 22 d after a single injection of isoperidone microspheres, and a sustained suppressive effect on the schizophrenic model was also observed. In comparison, the mouse group receiving oral daily administration exhibited more dose-dependent effects, and the pharmacological effect diminished rapidly in conjunction with a reduction of the plasma drug levels 8h after the last administration of isoperidone on day 3. The above results confirm the superiority of long-acting release over oral administration and indicate a valuable alternative for the clinical treatment of schizophrenia. Copyright © 2016 Elsevier B.V. All rights reserved.

78 FR 42524 - Leasing versus Renting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-16

... DEPARTMENT OF DEFENSE GENERAL SERVICES ADMINISTRATION NATIONAL AERONAUTICS AND SPACE... Defense (DoD), General Services Administration (GSA), and National Aeronautics and Space Administration... your attached document. Fax: 202-501-4067. Mail: General Services Administration, Regulatory...

48 CFR 1852.227-85 - Invention reporting and rights-Foreign.

Code of Federal Regulations, 2014 CFR

2014-10-01

... AERONAUTICS AND SPACE ADMINISTRATION CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of... States of America as represented by the Administrator of the National Aeronautics and Space... and Space Administration only an irrevocable, nontransferable, nonexclusive, royalty-free license to...

48 CFR 1852.227-85 - Invention reporting and rights-Foreign.

Code of Federal Regulations, 2012 CFR

2012-10-01

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48 CFR 1852.227-85 - Invention reporting and rights-Foreign.

Code of Federal Regulations, 2013 CFR

2013-10-01

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48 CFR 1852.227-85 - Invention reporting and rights-Foreign.

Code of Federal Regulations, 2011 CFR

2011-10-01

... AERONAUTICS AND SPACE ADMINISTRATION CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of... States of America as represented by the Administrator of the National Aeronautics and Space... and Space Administration only an irrevocable, nontransferable, nonexclusive, royalty-free license to...

78 FR 42110 - NASA Advisory Council; Human Exploration and Operations Committee; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-15

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2010-04-06

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76 FR 21073 - NASA Advisory Council; Science Committee; Earth Science Subcommittee; Meeting

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2011-04-14

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2010-10-26

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2012-05-09

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2012-09-20

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2013-08-22

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2013-03-26

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76 FR 49508 - NASA Advisory Council; Science Committee; Earth Science Subcommittee; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-10

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 11-073] NASA Advisory Council; Science Committee; Earth Science Subcommittee; Meeting AGENCY: National Aeronautics and Space Administration. ACTION... amended, the National Aeronautics and Space Administration (NASA) announces a meeting of the Earth Science...

75 FR 41899 - NASA Advisory Council; Science Committee; Earth Science Subcommittee; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-19

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (10-082)] NASA Advisory Council; Science Committee; Earth Science Subcommittee; Meeting AGENCY: National Aeronautics and Space Administration. ACTION... amended, the National Aeronautics and Space Administration (NASA) announces a meeting of the Earth Science...

77 FR 12086 - NASA Advisory Council; Science Committee; Earth Science Subcommittee; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-28

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 12-018] NASA Advisory Council; Science Committee; Earth Science Subcommittee; Meeting AGENCY: National Aeronautics and Space Administration. ACTION... amended, the National Aeronautics and Space Administration (NASA) announces a meeting of the Earth Science...

7 CFR 356.5 - Bonded release.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., in place of any property specified in § 356.1 and release the property to the owner or agent of the... 7 Agriculture 5 2010-01-01 2010-01-01 false Bonded release. 356.5 Section 356.5 Agriculture..., DEPARTMENT OF AGRICULTURE FORFEITURE PROCEDURES § 356.5 Bonded release. (a) The Deputy Administrator may...

28 CFR 523.12 - Work/study release good time.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Work/study release good time. 523.12..., CLASSIFICATION, AND TRANSFER COMPUTATION OF SENTENCE Extra Good Time § 523.12 Work/study release good time. Extra good time for an inmate in work or study release programs is awarded automatically, beginning on the...

28 CFR 523.12 - Work/study release good time.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., CLASSIFICATION, AND TRANSFER COMPUTATION OF SENTENCE Extra Good Time § 523.12 Work/study release good time. Extra good time for an inmate in work or study release programs is awarded automatically, beginning on the... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Work/study release good time. 523.12...

28 CFR 523.12 - Work/study release good time.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., CLASSIFICATION, AND TRANSFER COMPUTATION OF SENTENCE Extra Good Time § 523.12 Work/study release good time. Extra good time for an inmate in work or study release programs is awarded automatically, beginning on the... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Work/study release good time. 523.12...

45 CFR 211.7 - Transfer and release of eligible person.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Transfer and release of eligible person. (a) Transfer and release to relative. If at the time of arrival from a foreign country or any time during temporary or continuing care and treatment the Administrator... 45 Public Welfare 2 2014-10-01 2012-10-01 true Transfer and release of eligible person. 211.7...

28 CFR 523.12 - Work/study release good time.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., CLASSIFICATION, AND TRANSFER COMPUTATION OF SENTENCE Extra Good Time § 523.12 Work/study release good time. Extra good time for an inmate in work or study release programs is awarded automatically, beginning on the... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Work/study release good time. 523.12...

28 CFR 523.12 - Work/study release good time.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., CLASSIFICATION, AND TRANSFER COMPUTATION OF SENTENCE Extra Good Time § 523.12 Work/study release good time. Extra good time for an inmate in work or study release programs is awarded automatically, beginning on the... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Work/study release good time. 523.12...

Hubble Space Telescope (HST) high gain antenna (HGA) deployment during STS-31

NASA Image and Video Library

1990-04-25

Held in appendage deploy position, the Hubble Space Telescope's (HST's) high gain antenna (HGA) has been released from its stowed position along the Support System Module (SSM) forward shell. The STS-31 crew aboard Discovery, Orbiter Vehicle (OV) oversees the automatic HGA deployment prior to releasing HST. HST HGA is backdropped against the blackness of space.

75 FR 16197 - NASA Advisory Council; Space Operations Committee; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-31

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-036)] NASA Advisory Council; Space..., the National Aeronautics and Space Administration announces a meeting of the NASA Advisory Council Space Operations Committee. DATES: Tuesday, April 13, 2010, 3-5 p.m. CDT. ADDRESSES: NASA Johnson Space...

The National Space Weather Strategy: Policy on Observations

NASA Astrophysics Data System (ADS)

Murtagh, W. J.

2016-12-01

Ensuring that the United States is prepared to respond to and recover from severe space weather storms is a priority to the President and to this Administration. We cannot ignore the potential impact space weather may have on key infrastructures and technologies including aviation and satellite operations, the electric power grid, and GPS applications. These technologies form the very backbone of the critical technology infrastructure we rely on for so much of what we do today. In October 2015, OSTP Director John Holdren announced the release of the National Space Weather Strategy and the National Space Weather Action Plan. The Strategy identifies goals and establishes the principles that will guide efforts to develop national space-weather preparedness in both the near and long term, while the Action Plan identifies specific activities, outcomes, and timelines that the Federal government must pursue to be prepared for and resilient to future space-weather events. The Strategy recognizes that observations are the backbone of forecast and warning capabilities. The Strategy also recognized that to achieve a robust operational program for space-weather observations, the United States must: (1) establish and sustain a foundational set of observations; (2) when feasible and cost effective, use data from multiple sources, including international, Federal, State, and local governments, as well as from the academic and industry sectors; (3) ensure the continuity of critical data sources; (4) continue to support sensors for solar and space physics research; (5) ensure data-assimilation techniques are in place; and (6) maintain archives for ground- and space-based data, which are essential for model development and benchmarking. In this talk we explore elements in the Space Weather Action Plan that will ensure our Nation has the information we need to enhance resilience to the risk of space weather.

The Combined Release and Radiation Effects Satellite program (CRRES): A unique series of scientific experiments

NASA Technical Reports Server (NTRS)

1991-01-01

CRRES is a program to study the space environment which surrounds Earth and the effects of space radiation on modern satellite electronic systems. The satellite will carry an array of active experiments including chemical releases and a complement of sophisticated scientific instruments to accomplish these objectives. Other chemical release active experiments will be performed with suborbital rocket probes. These chemical releases will paint the magnetic and electric fields in Earthspace with clouds of glowing ions. Earthspace will be a laboratory, and the releases will be studied with an extensive network of ground-, aircraft-, and satellite-based diagnostic instruments.

KSC-02pd1856

NASA Image and Video Library

2002-12-05

KENNEDY SPACE CENTER, FLA. - Stephen Ezell, meteorological systems operator at Weather Station A, Cape Canaveral Air Force Station, walks out with a weather balloon that he will release. Such balloons are released twice a day. The package in Ezell's hand is a radio sonde that collects temperature and humidity data as the balloon rises. The data is released to agencies nationwide, including the 45th Space Wing which uses the data for its daily weather reports. The weather station provides additional data to NASA for launches - releasing 12 balloons in eight hours prior to liftoff - and landings - releasing 5 balloons in six and a half hours before expected touchdown.

KSC-02pd1860

NASA Image and Video Library

2002-12-05

KENNEDY SPACE CENTER, FLA. - At Weather Station A, Cape Canaveral Air Force Station, Judy Kelley, supervisor of Meteorology Operations, and Stephen Ezell, meteorological systems operator, get ready to release a weather balloon. Such balloons are released twice a day. The package at the bottom is a radio sonde that collects temperature and humidity data as the balloon rises. The data is released to agencies nationwide, including the 45th Space Wing, which uses the data for its daily weather reports. The weather station provides additional data to NASA for launches -- releasing 12 balloons in eight hours prior to liftoff - and landings - releasing 5 balloons in six and a half hours before expected touchdown.

Sustained release formulation of an anti-tuberculosis drug based on para-amino salicylic acid-zinc layered hydroxide nanocomposite.

PubMed

Saifullah, Bullo; Hussein, Mohd Zobir; Hussein-Al-Ali, Samer Hasan; Arulselvan, Palanisamy; Fakurazi, Sharida

2013-04-20

Tuberculosis (TB), is caused by the bacteria, Mycobacterium tuberculosis and its a threat to humans since centuries. Depending on the type of TB, its treatment can last for 6-24 months which is a major cause for patients non-compliance and treatment failure. Many adverse effects are associated with the currently available TB medicines, and there has been no new anti-tuberculosis drug on the market for more than 50 year, as the drug development is very lengthy and budget consuming process.Development of the biocompatible nano drug delivery systems with the ability to minimize the side effects of the drugs, protection of the drug from enzymatic degradation. And most importantly the drug delivery systems which can deliver the drug at target site would increase the therapeutic efficacy. Nanovehicles with their tendency to release the drug in a sustained manner would result in the bioavalibilty of the drugs in the body for a longer period of time and this would reduce the dosing frequency in drug administration. The biocompatible nanovehicles with the properties like sustained release of drug of the target site, protection of the drug from physio-chemical degradation, reduction in dosing frequency, and prolong bioavailability of drug in the body would result in the shortening of the treatment duration. All of these factors would improve the patient compliance with chemotherapy of TB. An anti-tuberculosis drug, 4-amino salicylic acid (4-ASA) was successfully intercalated into the interlamellae of zinc layered hydroxide (ZLH) via direct reaction with zinc oxide suspension. The X-ray diffraction patterns and FTIR analyses indicate that the molecule was successfully intercalated into the ZLH interlayer space with an average basal spacing of 24 Å. Furthermore, TGA and DTG results show that the drug 4-ASA is stabilized in the interlayers by electrostatic interaction. The release of 4-ASA from the nanocomposite was found to be in a sustained manner. The nanocomposite treated with normal 3T3 cells shows it reduces cell viability in a dose- and time-dependent manner. Sustained release formulation of the nanocomposite, 4-ASA intercalated into zinc layered hydroxides, with its ease of preparation, sustained release of the active and less-toxic to the cell is a step forward for a more patient-friendly chemotherapy of Tuberculosis.

Sustained release formulation of an anti-tuberculosis drug based on para-amino salicylic acid-zinc layered hydroxide nanocomposite

PubMed Central

2013-01-01

Background Tuberculosis (TB), is caused by the bacteria, Mycobacterium tuberculosis and its a threat to humans since centuries. Depending on the type of TB, its treatment can last for 6–24 months which is a major cause for patients non-compliance and treatment failure. Many adverse effects are associated with the currently available TB medicines, and there has been no new anti-tuberculosis drug on the market for more than 50 year, as the drug development is very lengthy and budget consuming process. Development of the biocompatible nano drug delivery systems with the ability to minimize the side effects of the drugs, protection of the drug from enzymatic degradation. And most importantly the drug delivery systems which can deliver the drug at target site would increase the therapeutic efficacy. Nanovehicles with their tendency to release the drug in a sustained manner would result in the bioavalibilty of the drugs in the body for a longer period of time and this would reduce the dosing frequency in drug administration. The biocompatible nanovehicles with the properties like sustained release of drug of the target site, protection of the drug from physio-chemical degradation, reduction in dosing frequency, and prolong bioavailability of drug in the body would result in the shortening of the treatment duration. All of these factors would improve the patient compliance with chemotherapy of TB. Result An anti-tuberculosis drug, 4-amino salicylic acid (4-ASA) was successfully intercalated into the interlamellae of zinc layered hydroxide (ZLH) via direct reaction with zinc oxide suspension. The X-ray diffraction patterns and FTIR analyses indicate that the molecule was successfully intercalated into the ZLH interlayer space with an average basal spacing of 24 Å. Furthermore, TGA and DTG results show that the drug 4-ASA is stabilized in the interlayers by electrostatic interaction. The release of 4-ASA from the nanocomposite was found to be in a sustained manner. The nanocomposite treated with normal 3T3 cells shows it reduces cell viability in a dose- and time-dependent manner. Conclusions Sustained release formulation of the nanocomposite, 4-ASA intercalated into zinc layered hydroxides, with its ease of preparation, sustained release of the active and less-toxic to the cell is a step forward for a more patient-friendly chemotherapy of Tuberculosis. PMID:23601852

78 FR 61398 - Notice of Intent To Grant Exclusive License

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-03

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 13-117] Notice of Intent To Grant Exclusive License AGENCY: National Aeronautics and Space Administration. ACTION: Notice of intent to grant exclusive... Aeronautics and Space Administration. The prospective exclusive license will comply with the terms and...

77 FR 66082 - NASA Advisory Council; Education and Public Outreach Committee; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-01

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 12-089] NASA Advisory Council; Education and... amended, the National Aeronautics and Space Administration announces a meeting of the Education and Public... Education and Public Outreach Committee, National Aeronautics and Space Administration, Washington, DC 20546...

1100398

NASA Image and Video Library

2011-03-24

CHARLES BOLDEN NASA ADMINISTRATOR TOURING AND SPEAKING AT THE US. SPACE AND ROCKET CENTER, HUNTSVILLE, ALABAMA. ACCOMPANYING ADMINISTRATOR BOLDEN ARE DR. DEBORAH BARNHART, CEO OF THE USSARC, ROBERT LIGHTFOOT, CENTER DIRECTOR OF MARSHALL SPACE FLIGHT CENTER AND RETIRED NASA ASTRONAUT ROBERT LEE “HOOT” GIBSON, ADMINISTRATOR BOLDEN’S FIRST SPACE FLIGHT COMMANDER.

The Chandra Source Catalog

NASA Astrophysics Data System (ADS)

Evans, Ian N.; Primini, F. A.; Glotfelty, K. J.; Anderson, C. S.; Bonaventura, N. R.; Chen, J. C.; Davis, J. E.; Doe, S. M.; Evans, J. D.; Fabbiano, G.; Galle, E. C.; Gibbs, D. G., II; Grier, J. D.; Hain, R. M.; Hall, D. M.; Harbo, P. N.; He, X.; Houck, J. C.; Karovska, M.; Kashyap, V. L.; Lauer, J.; McCollough, M. L.; McDowell, J. C.; Miller, J. B.; Mitschang, A. W.; Morgan, D. L.; Mossman, A. E.; Nichols, J. S.; Nowak, M. A.; Plummer, D. A.; Refsdal, B. L.; Rots, A. H.; Siemiginowska, A.; Sundheim, B. A.; Tibbetts, M. S.; Van Stone, D. W.; Winkelman, S. L.; Zografou, P.

2010-03-01

The Chandra Source Catalog (CSC) is a general purpose virtual X-ray astrophysics facility that provides access to a carefully selected set of generally useful quantities for individual X-ray sources, and is designed to satisfy the needs of a broad-based group of scientists, including those who may be less familiar with astronomical data analysis in the X-ray regime. The first release of the CSC includes information about 94,676 distinct X-ray sources detected in a subset of public ACIS imaging observations from roughly the first eight years of the Chandra mission. This release of the catalog includes point and compact sources with observed spatial extents < 30". The catalog (1) provides access to estimates of the X-ray source properties for detected sources with good scientific fidelity; (2) facilitates analysis of a wide range of statistical properties for classes of X-ray sources; and (3) provides efficient access to calibrated observational data and ancillary data products for individual X-ray sources. The catalog includes real X-ray sources detected with flux estimates that are at least 3 times their estimated 1σ uncertainties in at least one energy band, while maintaining the number of spurious sources at a level of < 1 false source per field for a 100 ks observation. For each detected source, the CSC provides commonly tabulated quantities, including source position, extent, multi-band fluxes, hardness ratios, and variability statistics. In addition, for each X-ray source the CSC includes an extensive set of file-based data products that can be manipulated interactively, including source images, event lists, light curves, and spectra. Support for development of the CSC is provided by the National Aeronautics and Space Administration through the Chandra X-ray Center, which is operated by the Smithsonian Astrophysical Observatory for and on behalf of the National Aeronautics and Space Administration under contract NAS 8-03060.

78 FR 66964 - International Space Station Advisory Committee; Charter Renewal

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-07

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (13-128)] International Space Station Advisory Committee; Charter Renewal AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of renewal and amendment of the charter of the International Space Station Advisory Committee...

78 FR 66964 - International Space Station National Laboratory Advisory Committee; Charter Renewal

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-07

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (13-129)] International Space Station National Laboratory Advisory Committee; Charter Renewal AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of renewal of the charter of the International Space Station National...

76 FR 65752 - International Space Station (ISS) National Laboratory Advisory Committee; Charter Renewal

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-24

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (11-104)] International Space Station (ISS) National Laboratory Advisory Committee; Charter Renewal AGENCY: National Aeronautics and Space... International and Interagency Relations, (202) 358-0550, National Aeronautics and Space Administration...

Effect of co-administration of probiotics with polysaccharide based colon targeted delivery systems to optimize site specific drug release.

PubMed

Prudhviraj, G; Vaidya, Yogyata; Singh, Sachin Kumar; Yadav, Ankit Kumar; Kaur, Puneet; Gulati, Monica; Gowthamarajan, K

2015-11-01

Significant clinical success of colon targeted dosage forms has been limited by their inappropriate release profile at the target site. Their failure to release the drug completely in the colon may be attributed to changes in the colonic milieu because of pathological state, drug effect and psychological stress accompanying the diseased state or, a combination of these. Alteration in normal colonic pH and bacterial picture leads to incomplete release of drug from the designed delivery system. We report the effectiveness of a targeted delivery system wherein the constant replenishment of the colonic microbiota is achieved by concomitant administration of probiotics along with the polysaccharide based drug delivery system. Guar gum coated spheroids of sulfasalazine were prepared. In the dissolution studies, these spheroids showed markedly higher release in the simulated colonic fluid. In vivo experiments conducted in rats clearly demonstrated the therapeutic advantage of co-administration of probiotics with guar gum coated spheroids. Our results suggest that concomitant use of probiotics along with the polysaccharide based delivery systems can be a simple strategy to achieve satisfactory colon targeting of drugs. Copyright © 2015 Elsevier B.V. All rights reserved.

49 CFR 236.791 - Release, value.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Release, value. 236.791 Section 236.791 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Release, value. The electrical value at which the movable member of an electromagnetic device will move to...

76 FR 1195 - Privacy Act System of Records Notice (11-001)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-07

... Aeronautics and Space Administration Washington, DC 20546-0001 Location 2 Ames Research Center, National Aeronautics and Space Administration, Moffett Field, CA 94035-1000 Location 3 Dryden Flight Research Center... Center, FL 32899-0001 Location 7 Langley Research Center, National Aeronautics and Space Administration...

14 CFR 1212.702 - Associate Administrator for Management Systems and Facilities.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Associate Administrator for Management Systems and Facilities. 1212.702 Section 1212.702 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PRIVACY ACT-NASA REGULATIONS NASA Authority and Responsibilities § 1212.702 Associate...

14 CFR 1212.702 - Associate Administrator for Management Systems and Facilities.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Associate Administrator for Management Systems and Facilities. 1212.702 Section 1212.702 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PRIVACY ACT-NASA REGULATIONS NASA Authority and Responsibilities § 1212.702 Associate...

Striatal dopamine release in vivo following neurotoxic doses of methamphetamine and effect of the neuroprotective drugs, chlormethiazole and dizocilpine.

PubMed

Baldwin, H A; Colado, M I; Murray, T K; De Souza, R J; Green, A R

1993-03-01

1. Administration to rats of methamphetamine (15 mg kg-1, i.p.) every 2 h to a total of 4 doses resulted in a neurotoxic loss of striatal dopamine of 36% and of 5-hydroxytryptamine (5-HT) in the cortex (43%) and hippocampus (47%) 3 days later. 2. Administration of chlormethiazole (50 mg kg-1, i.p.) 15 min before each dose of methamphetamine provided complete protection against the neurotoxic loss of monoamines while administration of dizocilpine (1 mg kg-1, i.p.) using the same dose schedule provided substantial protection. 3. Measurement of dopamine release in the striatum by in vivo microdialysis revealed that methamphetamine produced an approximate 7000% increase in dopamine release after the first injection. The enhanced release response was somewhat diminished after the third injection but still around 4000% above baseline. Dizocilpine (1 mg kg-1, i.p.) did not alter this response but chlormethiazole (50 mg kg-1, i.p.) attenuated the methamphetamine-induced release by approximately 40%. 4. Dizocilpine pretreatment did not influence the decrease in the dialysate concentration of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) produced by administration of methamphetamine while chlormethiazole pretreatment decreased the dialysate concentration of these metabolites still further. 5. The concentration of dopamine in the dialysate during basal conditions increased modestly during the course of the experiment. This increase did not occur in chlormethiazole-treated rats. HVA concentrations were unaltered by chlormethiazole administration. 6. Chlormethiazole (100-1000 microM) did not alter methamphetamine (100 microM) or K+ (35 mM)-evoked release of endogenous dopamine from striatal prisms in vitro. 7. Several NMDA antagonists prevent methamphetamine-induced neurotoxicity; however chlormethiazole is not an NMDA antagonist. Inhibition of striatal dopamine function prevents methamphetamine-induced toxicity of both dopamine and 5-HT pathways. Therefore the attenuation of the enhanced dopamine release which occurs in animals given chlormethiazole may be associated with the protective action of this drug against methamphetamine-induced neurotoxicity.

Sublingual fast dissolving niosomal films for enhanced bioavailability and prolonged effect of metoprolol tartrate.

PubMed

Allam, Ayat; Fetih, Gihan

2016-01-01

The aim of the present work was to prepare and evaluate sublingual fast dissolving films containing metoprolol tartrate-loaded niosomes. Niosomes were utilized to allow for prolonged release of the drug, whereas the films were used to increase the drug's bioavailability via the sublingual route. Niosomes were prepared using span 60 and cholesterol at different drug to surfactant ratios. The niosomes were characterized for size, zeta-potential, and entrapment efficiency. The selected niosomal formulation was incorporated into polymeric films using hydroxypropyl methyl cellulose E15 and methyl cellulose as film-forming polymers and Avicel as superdisintegrant. The physical characteristics (appearance, texture, pH, uniformity of weight and thickness, disintegration time, and palatability) of the prepared films were studied, in addition to evaluating the in vitro drug release, stability, and in vivo pharmacokinetics in rabbits. The release of the drug from the medicated film was fast (99.9% of the drug was released within 30 minutes), while the drug loaded into the niosomes, either incorporated into the film or not, showed only 22.85% drug release within the same time. The selected sublingual film showed significantly higher rate of drug absorption and higher drug plasma levels compared with that of commercial oral tablet. The plasma levels remained detectable for 24 hours following sublingual administration, compared with only 12 hours after administration of the oral tablet. In addition, the absolute bioavailability of the drug (ie, relative to intravenous administration) following sublingual administration was found to be significantly higher (91.06%±13.28%), as compared with that after oral tablet administration (39.37%±11.4%). These results indicate that the fast dissolving niosomal film could be a promising delivery system to enhance the bioavailability and prolong the therapeutic effect of metoprolol tartrate.

Sublingual fast dissolving niosomal films for enhanced bioavailability and prolonged effect of metoprolol tartrate

PubMed Central

Allam, Ayat; Fetih, Gihan

2016-01-01

The aim of the present work was to prepare and evaluate sublingual fast dissolving films containing metoprolol tartrate-loaded niosomes. Niosomes were utilized to allow for prolonged release of the drug, whereas the films were used to increase the drug’s bioavailability via the sublingual route. Niosomes were prepared using span 60 and cholesterol at different drug to surfactant ratios. The niosomes were characterized for size, zeta-potential, and entrapment efficiency. The selected niosomal formulation was incorporated into polymeric films using hydroxypropyl methyl cellulose E15 and methyl cellulose as film-forming polymers and Avicel as superdisintegrant. The physical characteristics (appearance, texture, pH, uniformity of weight and thickness, disintegration time, and palatability) of the prepared films were studied, in addition to evaluating the in vitro drug release, stability, and in vivo pharmacokinetics in rabbits. The release of the drug from the medicated film was fast (99.9% of the drug was released within 30 minutes), while the drug loaded into the niosomes, either incorporated into the film or not, showed only 22.85% drug release within the same time. The selected sublingual film showed significantly higher rate of drug absorption and higher drug plasma levels compared with that of commercial oral tablet. The plasma levels remained detectable for 24 hours following sublingual administration, compared with only 12 hours after administration of the oral tablet. In addition, the absolute bioavailability of the drug (ie, relative to intravenous administration) following sublingual administration was found to be significantly higher (91.06%±13.28%), as compared with that after oral tablet administration (39.37%±11.4%). These results indicate that the fast dissolving niosomal film could be a promising delivery system to enhance the bioavailability and prolong the therapeutic effect of metoprolol tartrate. PMID:27536063

Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis.

PubMed

Jayasena, Channa N; Nijher, Gurjinder M K; Chaudhri, Owais B; Murphy, Kevin G; Ranger, Amita; Lim, Adrian; Patel, Daksha; Mehta, Amrish; Todd, Catriona; Ramachandran, Radha; Salem, Victoria; Stamp, Gordon W; Donaldson, Mandy; Ghatei, Mohammad A; Bloom, Stephen R; Dhillo, Waljit S

2009-11-01

Kisspeptin is a critical regulator of normal reproductive function. A single injection of kisspeptin in healthy human volunteers potently stimulates gonadotropin release. However, the effects of kisspeptin on gonadotropin release in women with hypothalamic amenorrhea (HA) and the effects of repeated administration of kisspeptin to humans are unknown. The aim of this study was to determine the effects of acute and chronic kisspeptin administration on gonadotropin release in women with HA. We performed a prospective, randomized, double-blinded, parallel design study. Women with HA received twice-daily sc injections of kisspeptin (6.4 nmol/kg) or 0.9% saline (n = 5 per group) for 2 wk. Changes in serum gonadotropin and estradiol levels, LH pulsatility, and ultrasound measurements of reproductive activity were assessed. On the first injection day, potent increases in serum LH and FSH were observed after sc kisspeptin injection in women with HA (mean maximal increment from baseline within 4 h after injection: LH, 24.0 +/- 3.5 IU/liter; FSH, 9.1 +/- 2.5 IU/liter). These responses were significantly reduced on the 14th injection day (mean maximal increment from baseline within 4 h postinjection: LH, 2.5 +/- 2.2 IU/liter, P < 0.05; FSH, 0.5 +/- 0.5 IU/liter, P < 0.05). Subjects remained responsive to GnRH after kisspeptin treatment. No significant changes in LH pulsatility or ultrasound measurements of reproductive activity were observed. Acute administration of kisspeptin to women with infertility due to HA potently stimulates gonadotropin release, but chronic administration of kisspeptin results in desensitization to its effects on gonadotropin release. These data have important implications for the development of kisspeptin as a novel therapy for reproductive disorders in humans.

Budgeting Academic Space

ERIC Educational Resources Information Center

Harris, Watson

2011-01-01

There are many articles about space management, including those that discuss space calculations, metrics, and categories. Fewer articles discuss the space budgeting processes used by administrators to allocate space. The author attempts to fill this void by discussing her administrative experiences with Middle Tennessee State University's (MTSU)…

The Effects of Neutral Gas Release on Vehicle Charging: Experiment and Theory

NASA Astrophysics Data System (ADS)

Walker, D. N.; Amatucci, W. E.; Bowles, J. H.; Fernsler, R. F.; Siefring, C. L.; Antoniades, J. A.; Keskinen, M. J.

1998-11-01

This paper describes an experimental and theoretical research effort related to the mitigation of spacecraft charging by Neutral Gas Release (NGR). The Space Power Experiments Aboard Rockets programs (SPEAR I and III) [Mandel et al., 1998; Berg et al., 1995] and other earlier efforts have demonstrated that NGR is an effective method of controlling discharges in space. The laboratory experimentswere conducted in the large volume Space Physics Simulation Chamber (SPSC) at the Naval Research Laboratory (NRL). A realistic near-earth space environment can be simulated in this device for whichminimumscalingneeds to be performedtorelate the data to space plasma regimes. This environment is similar to that encountered by LEO spacecraft, e.g., the Space Station, Shuttle, and high inclination satellites. The experimental arrangement consists of an aluminum cylinder which can be biased to high negative voltage (0.4 kV

Earth Science

NASA Image and Video Library

1991-01-01

In July 1990, the Marshall Space Flight Center, in a joint project with the Department of Defense/Air Force Space Test Program, launched the Combined Release and Radiation Effects Satellite (CRRES) using an Atlas I launch vehicle. The mission was designed to study the effects of artificial ion clouds produced by chemical releases on the Earth's ionosphere and magnetosphere, and to monitor the effects of space radiation environment on sophisticated electronics.

KSC01pp0680

NASA Image and Video Library

2001-04-03

KENNEDY SPACE CENTER, FLA. -- Sea World workers wade into the Banana River carrying a young manatee they are releasing. The site is on the north side of the NASA Causeway, near Kennedy Space Center. The calf was one of two manatees being released after recovering from injuries. Manatees are frequently seen in the waters around Kennedy Space Center, which is surrounded by the Merritt Island National Wildlife Refuge

Effects of luteinizing hormone-releasing hormone and arginine-vasotocin on the sperm-release response of Günther's Toadlet, Pseudophryne guentheri

PubMed Central

2010-01-01

Background Luteinizing hormone-releasing hormone (LHRH) is an exogenous hormone commonly used to induce spermiation in anuran amphibians. Over the past few decades, the LHRH dose administered to individuals and the frequency of injection has been highly variable. The sperm-release responses reported have been correspondingly diverse, highlighting a need to quantify dose-response relationships on a species-specific basis. This study on the Australian anuran Pseudophryne guentheri first evaluated the spermiation response of males administered one of five LHRHa doses, and second, determined whether AVT administered in combination with the optimal LHRHa dose improved sperm-release. Methods Male toadlets were administered a single dose of 0, 1, 2, 4 or 8 micrograms/g body weight of LHRHa. A 4 micrograms/g dose of AVT was administered alone or in combination with 2 micrograms/g LHRHa. Spermiation responses were evaluated at 3, 7 and 12 h post hormone administration (PA), and sperm number and viability were quantified using fluorescent microscopy. Results LHRHa administration was highly effective at inducing spermiation in P. guentheri, with 100% of hormone-treated males producing sperm during the experimental period. The number of sperm released in response to 2 micrograms/g LHRHa was greater than all other doses administered and sperm viability was highest in the 1 microgram/g treatment. The administration of AVT alone or in combination with LHRHa resulted in the release of significantly lower sperm numbers. Conclusion Overall, results from this study suggest that in P. guentheri, LHRHa is effective at inducing spermiation, but that AVT inhibits sperm-release. PMID:21059269

78 FR 20168 - Notice of Intent To Rule on Request To Release Airport Property at the Boulder Municipal Airport...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-03

... To Release Airport Property at the Boulder Municipal Airport, Boulder, CO AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of request to release airport property. SUMMARY: The FAA proposes to rule and invite public comment on the release of land at Boulder Municipal Airport under the provisions...

76 FR 23854 - Notice of Intent To Rule on Request To Release Airport Property at the Dubois Regional Airport...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-28

... To Release Airport Property at the Dubois Regional Airport, Reynoldsville, PA AGENCY: Federal Aviation Administration (FAA) DOT. ACTION: Notice of request to release airport property. SUMMARY: The FAA proposes to rule and invite public comment on the release of land at the Dubois Regional Airport...

75 FR 43565 - NASA Advisory Council; Ad-Hoc Task Force on Planetary Defense; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-26

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (10-084)] NASA Advisory Council; Ad-Hoc Task Force on Planetary Defense; Meeting AGENCY: National Aeronautics and Space Administration. ACTION... amended, the National Aeronautics and Space Administration announces a two-part meeting of the Ad-Hoc Task...

75 FR 33838 - NASA Advisory Council; Ad-Hoc Task Force on Planetary Defense; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-15

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-065)] NASA Advisory Council; Ad-Hoc Task Force on Planetary Defense; Meeting AGENCY: National Aeronautics and Space Administration. ACTION... amended, the National Aeronautics and Space Administration announces a meeting of the Ad-Hoc Task Force on...

75 FR 15742 - NASA Advisory Council; Ad-Hoc Task Force on Planetary Defense; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-30

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (10-035)] NASA Advisory Council; Ad-Hoc Task Force on Planetary Defense; Meeting AGENCY: National Aeronautics and Space Administration. ACTION... amended, the National Aeronautics and Space Administration announces a meeting of the Ad-Hoc Task Force on...

75 FR 24781 - Task Force on Space Industry Workforce and Economic Development

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-06

... of May 3, 2010 Task Force on Space Industry Workforce and Economic Development Memorandum for the... Administrator of the National Aeronautics and Space Administration[,] the Chair of the Council of Economic... Policy[, and] the Director of the National Economic Council My Administration is committed to...

75 FR 4875 - NASA Commercial Space Committee; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-29

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (10-014)] NASA Commercial Space Committee... and Space Administration announces a meeting of the Commercial Space Committee to the NASA Advisory Council. DATES: Tuesday, February 16, 2010, 10 a.m.-5 p.m., Eastern. ADDRESSES: NASA Headquarters, 300 E...

14 CFR 1204.1403 - Available airport facilities.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Available airport facilities. 1204.1403 Section 1204.1403 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION ADMINISTRATIVE... for improved braking under wet conditions. (2) Parking Areas and Hangar Space. No hangar space is...

76 FR 65540 - National Space-Based Positioning, Navigation, and Timing (PNT) Advisory Board; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-21

.... James J. Miller, Human Exploration and Operations Mission Directorate, National Aeronautics and Space... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (11-099)] National Space-Based Positioning, Navigation, and Timing (PNT) Advisory Board; Meeting AGENCY: National Aeronautics and Space Administration...

7 CFR 356.5 - Bonded release.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 5 2012-01-01 2012-01-01 false Bonded release. 356.5 Section 356.5 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FORFEITURE PROCEDURES § 356.5 Bonded release. (a) The Deputy Administrator may...

7 CFR 1.19 - Exemptions and discretionary release.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 1 2013-01-01 2013-01-01 false Exemptions and discretionary release. 1.19 Section 1.19 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Official Records § 1.19 Exemptions and discretionary release. (a) All agency records, except those specifically exempted...

75 FR 60145 - PNT Advisory Board; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-29

... J. Miller, Space Communications and Navigation Program, Space Operations Mission Directorate... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-114)] PNT Advisory Board; Meeting AGENCY: National Aeronautics and Space Administration. ACTION: Notice of Meeting. SUMMARY: In accordance with the...

Space transportation forecast conference, February 10-11, 1998 : Quarterly Launch Report : special report

DOT National Transportation Integrated Search

1998-01-01

The Federal Aviation Administration's Associate Administrator for Commercial Space Transportation (AST) convened the first national commercial space transportation forecast conference on February 10-11, 1998. For the theme, Commercial Space Transport...

STS-72 Endeavour, Orbiter Vehicle (OV-105), crew insignia

NASA Image and Video Library

1995-05-01

STS072-S-001 (May 1995) --- The crew patch of STS-72 depicts the space shuttle Endeavour and some of the payloads on the flight. The Japanese satellite, Space Flyer Unit (SFU) is shown in a free-flying configuration with the solar array panels deployed. The inner gold border of the patch represents the SFU's distinct octagonal shape. Endeavour will rendezvous with and retrieve SFU at an altitude of approximately 250 nautical miles. The Office of Aeronautics and Space Technology's (OAST) flyer satellite is shown just after release from the Remote Manipulator System (RMS). The OAST satellite will be deployed at an altitude of 165 nautical miles to fly free for two days gathering scientific data. The payload bay contains equipment for the secondary payloads - the Shuttle Laser Altimeter (SLA) and the Shuttle Solar Backscatter Ultraviolet Instrument (SSBUI). There are two spacewalks planned to test hardware for assembly of the International Space Station. The stars represent the hometowns of the crew members in the United States and Japan. The NASA insignia design for space shuttle flights is reserved for use by the astronauts and for other official use as the NASA Administrator may authorize. Public availability has been approved only in the forms of illustrations by the various news media. When and if there is any change in this policy, which is not anticipated, the change will be publicly announced. Photo credit: NASA

Tyrosine - Effects on catecholamine release

NASA Technical Reports Server (NTRS)

Acworth, Ian N.; During, Matthew J.; Wurtman, Richard J.

1988-01-01

Tyrosine administration elevates striatal levels of dopamine metabolites in animals given treatments that accelerate nigrostriatal firing, but not in untreated rats. We examined the possibility that the amino acid might actually enhance dopamine release in untreated animals, but that the technique of measuring striatal dopamine metabolism was too insensitive to demonstrate such an effect. Dopamine release was assessed directly, using brain microdialysis of striatal extracellular fluid. Tyrosine administration (50-200 mg/kg IP) did indeed cause a dose related increase in extracellular fluid dopamine levels with minor elevations in levels of DOPAC and HVA, its major metabolites, which were not dose-related. The rise in dopamine was short-lived, suggesting that receptor-mediated feedback mechanisms responded to the increased dopamine release by diminishing neuronal firing or sensitivity to tyrosine. These observations indicate that measurement of changes in striatal DOPAC and HVA, if negative, need not rule out increases in nigrostriatal dopamine release.

Ghrelin, a novel growth hormone-releasing peptide, in the treatment of cardiopulmonary-associated cachexia.

PubMed

Nagaya, Noritoshi; Kojima, Masakazu; Kangawa, Kenji

2006-01-01

Ghrelin is a novel growth hormone (GH)-releasing peptide, isolated from the stomach, which has been identified as an endogenous ligand for GH secretagogue receptor. The discovery of ghrelin indicates that the release of GH from the pituitary might be regulated not only by hypothalamic GH-releasing hormone, but also by ghrelin derived from the stomach. This peptide also stimulates food intake and induces adiposity through GH-independent mechanisms. In addition, ghrelin acts directly on the central nervous system to decrease sympathetic nerve activity. Thus, ghrelin plays important roles for maintaining GH release and energy homeostasis. Repeated administration of ghrelin improves body composition, muscle wasting, functional capacity, and sympathetic augmentation in cachectic patients with heart failure or chronic obstructive pulmonary disease. These results suggest that ghrelin has anti-cachectic effects through GH-dependent and independent mechanisms. Thus, administration of ghrelin may be a new therapeutic strategy for the treatment of cardiopulmonary-associated cachexia.

Azathioprine pharmacokinetics after intravenous, oral, delayed release oral and rectal foam administration.

PubMed Central

Van Os, E C; Zins, B J; Sandborn, W J; Mays, D C; Tremaine, W J; Mahoney, D W; Zinsmeister, A R; Lipsky, J J

1996-01-01

BACKGROUND: 6-Mercaptopurine and its prodrug azathioprine are effective medications for refractory inflammatory bowel disease. However, use of these drugs has been limited by concerns about their toxicity. Colonic delivery of azathioprine may reduce its systemic bioavailability and limit toxicity. AIM: To determine the bioavailability of 6-mercaptopurine after administration of azathioprine via three colonic delivery formulations. METHODS: Twenty four healthy human subjects each received 50 mg of azathioprine by one of four delivery formulations (each n = 6): oral; delayed release oral; hydrophobic rectal foam; and hydrophilic rectal foam. All subjects also received a 50 mg dose of intravenous azathioprine during a separate study period. Plasma concentrations of 6-mercaptopurine were determined by high pressure liquid chromatography. RESULTS: The bioavailabilities of 6-mercaptopurine after colonic azathioprine administration via delayed release oral, hydrophobic rectal foam, and hydrophilic rectal foam (7%, 5%, 1%; respectively) were significantly lower than the bioavailability of 6-mercaptopurine after oral azathioprine administration (47%) by Wilcoxon rank sum pairwise comparison. CONCLUSIONS: Azathioprine delivered to the colon by delayed release oral and rectal foam formulations considerably reduced systemic 6-mercaptopurine bioavailability. The therapeutic potential of these colonic delivery methods, which can potentially limit toxicity by local delivery of high doses of azathioprine, should be investigated in patients with inflammatory bowel disease. PMID:8881811

Preparation and investigation of acetyl salicylic acid-caffeine complex for rectal administration.

PubMed

Fouad, Ehab A; El-Badry, Mahmoud; Alanazi, Fars K; Arafah, Maha M; Al-Ashban, Riyadh; Alsarra, Ibrahim A

2010-06-01

An acetyl salicylic acid-caffeine complex was prepared and evaluated for the potential use in rectal administration. The results revealed the formation of a complex between acetyl salicylic acid and caffeine in a 1:1 molar ratio by a charge transfer mechanism. The effects of acetyl salicylic acid and complex on the rectal tissues showed destruction in the mucosal epithelium in case of acetyl salicylic acid; however, no change in the rectal tissues was noticed upon the administration of the complex. The effect of suppository bases on the release of the complex was studied using Witepsol H15 as fatty base and polyethylene glycols (PEG) 1000 and 4000 as a water soluble suppository base. The release profiles of acetyl salicylic acid and the complex were faster from PEG than from that of Witepsol H15. The percent release for the complex and acetyl salicylic acid from PEG base were 45.8, and 34.9%, respectively. However, it was 8.7 and 7.8%, respectively, from Witepsol H15 fatty base. The release kinetic was found to follow the non-Fickian diffusion model for complex from the suppository bases. It was concluded that acetyl salicylic acid caffeine complex can be used safely for rectal administration.

Preparation and investigation of acetyl salicylic acid-caffeine complex for rectal administration.

PubMed

Fouad, Ehab A; El-Badry, Mahmoud; Alanazi, Fars K; Arafah, Maha M; Al-Ashban, Riyadh; Alsarra, Ibrahim A

2009-07-30

An acetyl salicylic acid-caffeine complex was prepared and evaluated for the potential use in rectal administration. The results revealed the formation of a complex between acetyl salicylic acid and caffeine in a 1:1 molar ratio by a charge transfer mechanism. The effects of acetyl salicylic acid and complex on the rectal tissues showed destruction in the mucosal epithelium in case of acetyl salicylic acid; however, no change in the rectal tissues was noticed upon the administration of the complex. The effect of suppository bases on the release of the complex was studied using Witepsol H15 as fatty base and polyethylene glycols (PEG) 1000 and 4000 as a water soluble suppository base. The release profiles of acetyl salicylic acid and the complex were faster from PEG than from that of Witepsol H15. The percent release for the complex and acetyl salicylic acid from PEG base were 45.8, and 34.9%, respectively. However, it was 8.7 and 7.8%, respectively, from Witepsol H15 fatty base. The release kinetic was found to follow the non-Fickian diffusion model for complex from the suppository bases. It was concluded that acetyl salicylic acid caffeine complex can be used safely for rectal administration.

Central administration of orexin A suppresses basal and domperidone stimulated plasma prolactin.

PubMed

Russell, S H; Kim, M S; Small, C J; Abbott, C R; Morgan, D G; Taheri, S; Murphy, K G; Todd, J F; Ghatei, M A; Bloom, S R

2000-12-01

Orexin immunoreactive fibres are abundant in the hypothalamus suggesting a neuroendocrine regulatory role. Intracerebroventricular (ICV) administration of orexin A suppressed plasma prolactin in male rats by 71% at 20 min post-injection and 83% at 90 min post-injection (P < 0.005 vs saline at both time points). To investigate whether this effect was through the tuberoinfundibular dopaminergic (TIDA) system, a supra-maximal dose of domperidone, a dopamine receptor antagonist, was injected intraperitoneally (i.p.) prior to ICV injection of orexin A. ICV orexin A significantly suppressed domperidone (9 mg/kg)-stimulated plasma prolactin levels, by up to 40% (i.p. domperidone + ICV orexin A 3 nmol 34.5 +/- 7.4 ng/ml and i.p. domperidone + ICV orexin A 20 nmol 43.5 +/- 4.3 ng/ml, both P < 0.005 vs i.p. domperidone + ICV saline 57.9 +/- 2.7 ng/ml). Orexin A, 100 nM, significantly stimulated release of neurotensin, vasoactive intestinal polypeptide, somatostatin, corticotropin releasing factor and luteinizing hormone releasing hormone, but had no effect on release of dopamine, thyrotropin releasing hormone (TRH), vasopressin or melanin-concentrating hormone from hypothalamic explants in vitro. Orexin A did not alter basal or TRH stimulated prolactin release in dispersed pituitary cells harvested from male rats. The data suggest that ICV administration of orexin A suppresses plasma prolactin in part through a pathway independent of the dopaminergic system.

14 CFR 1214.1707 - Media and public inquiries.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Media and public inquiries. 1214.1707 Section 1214.1707 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Space Flight Participants § 1214.1707 Media and public inquiries. (a) The Associate Administrator for External...

14 CFR 1214.1707 - Media and public inquiries.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Media and public inquiries. 1214.1707 Section 1214.1707 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Space Flight Participants § 1214.1707 Media and public inquiries. (a) The Associate Administrator for External...

14 CFR 1214.1707 - Media and public inquiries.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Media and public inquiries. 1214.1707 Section 1214.1707 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Space Flight Participants § 1214.1707 Media and public inquiries. (a) The Associate Administrator for External...

14 CFR 1214.1707 - Media and public inquiries.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Media and public inquiries. 1214.1707 Section 1214.1707 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Space Flight Participants § 1214.1707 Media and public inquiries. (a) The Associate Administrator for External...

14 CFR 1214.1106 - Selection of astronaut candidates.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Selection of astronaut candidates. 1214.1106 Section 1214.1106 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT NASA... be approved, as required, by JSC/ NASA management and the Associate Administrator for Space Flight...

Single-dose evaluation of safety, tolerability and pharmacokinetics of newly formulated hydromorphone immediate-release and hydrophilic matrix extended-release tablets in healthy Japanese subjects without co-administration of an opioid antagonist.

PubMed

Toyama, Kaoru; Uchida, Naoki; Ishizuka, Hitoshi; Sambe, Takehiko; Kobayashi, Shinichi

2015-09-01

This single dose, open-label study investigated the safety, tolerability and pharmacokinetics of single oral doses of newly formulated immediate-release (IR) and hydrophilic matrix extended-release (ER) hydromorphone tablets in healthy Japanese subjects without co-administration of an opioid antagonist under fasting and fed conditions. Plasma and urinary concentrations of hydromorphone and metabolites were measured by liquid-chromatography tandem mass-spectroscopy. Following administration of the ER tablet, plasma concentrations of hydromorphone slowly increased with a median tmax of 5.0 h and the Cmax decreased to 37% of the IR tablet, while the AUC0-inf was comparable with that of the IR tablet when administered at the same dose. The degree of fluctuation in the plasma concentration for the ER tablet was much lower than that of the IR tablet and certain levels of plasma concentrations were maintained after 24 h of ER dosing. The AUC0-inf and Cmax increased with food for both IR and ER tablets. The AUC0-inf of hydromorphone-3-glucoside was one-tenth of that of hydromorphone-3-glucuronide. A single oral administration of the hydromorphone tablets would be well-tolerated in healthy Japanese subjects despite a lack of co-administration of an opioid antagonist and the newly developed ER hydromorphone tablets may have the appropriate PK characteristics for once-daily dosing. © 2015, The American College of Clinical Pharmacology.

Methylphenidate and Cocaine Self-Administration Produce Distinct Dopamine Terminal Alterations

PubMed Central

Calipari, Erin S.; Ferris, Mark J.; Melchior, James R.; Bermejo, Kristel; Salahpour, Ali; Roberts, David C. S.; Jones, Sara R.

2012-01-01

Methylphenidate (MPH) is a commonly abused psychostimulant prescribed for the treatment of attention deficit hyperactivity disorder. MPH has a mechanism of action similar to cocaine (COC) and is commonly characterized as a dopamine transporter (DAT) blocker. While there has been extensive work aimed at understanding dopamine (DA) nerve terminal changes following COC self-administration, very little is known about the effects of MPH self-administration on the DA system. We used fast scan cyclic voltammetry in nucleus accumbens core slices from animals with a five-day self-administration history of 40 injections/day of either MPH (0.56 mg/kg) or COC (1.5 mg/kg) to explore alterations in baseline DA release and uptake kinetics as well as alterations in the interaction of each compound with the DAT. Although MPH and COC have similar behavioral effects, the consequences of self-administration on DA system parameters were found to be divergent. We show that COC self-administration reduced DAT levels and maximal rates of DA uptake, as well as reducing electrically stimulated release, suggesting decreased DA terminal function. In contrast, MPH self-administration increased DAT levels, DA uptake rates, and DA release, suggesting enhanced terminal function, which was supported by findings of increased metabolite/DA tissue content ratios. Tyrosine hydroxylase mRNA, protein and phosphorylation levels were also assessed in both groups. Additionally, COC self-administration reduced COC-induced DAT inhibition, while MPH self-administration increased MPH-induced DAT inhibition, suggesting opposite pharmacodynamic effects of these two drugs. These findings suggest that the factors governing DA system adaptations are more complicated than simple DA uptake blockade. PMID:22458761

The Combined Release and Radiation Effects Satellite (CRRES) program: A unique series of scientific experiments

NASA Technical Reports Server (NTRS)

Reasoner, David L.; Mccook, Morgan W. (Editor); Vaughan, William W. (Editor)

1990-01-01

The Defense Department and NASA have joined in a program to study the space environment which surrounds the earth and the effects of space radiation on modern satellite electronic systems. The Combined Release and Radiation Effects Satellite (CRRES) will carry an array of active experiments including chemical releases and a complement of sophisticated scientific instruments to accomplish these objectives. Other chemical release active experiments will be performed with sub-orbital rocket probes. The chemical releases will 'paint' the magnetic and electric fields of earthspace with clouds of glowing ions. Earthspace will be a laboratory, and the releases will be studied with an extensive network of ground-, aircraft-, and satellite-based diagnostic instruments. Some of the topics discussed include the following: the effects of earthspace; the need for active experiments; types of chemical releases; the CRRES program schedule; international support and coordinated studies; photographing chemical releases; information on locating chemical releases for observation by the amateur; and CRRES as a program.

The Combined Release and Radiation Effects Satellite (CRRES) program: A unique series of scientific experiments

NASA Astrophysics Data System (ADS)

Reasoner, David L.; McCook, Morgan W.; Vaughan, William W.

The Defense Department and NASA have joined in a program to study the space environment which surrounds the earth and the effects of space radiation on modern satellite electronic systems. The Combined Release and Radiation Effects Satellite (CRRES) will carry an array of active experiments including chemical releases and a complement of sophisticated scientific instruments to accomplish these objectives. Other chemical release active experiments will be performed with sub-orbital rocket probes. The chemical releases will 'paint' the magnetic and electric fields of earthspace with clouds of glowing ions. Earthspace will be a laboratory, and the releases will be studied with an extensive network of ground-, aircraft-, and satellite-based diagnostic instruments. Some of the topics discussed include the following: the effects of earthspace; the need for active experiments; types of chemical releases; the CRRES program schedule; international support and coordinated studies; photographing chemical releases; information on locating chemical releases for observation by the amateur; and CRRES as a program.

78 FR 72719 - NASA Advisory Council; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-03

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (13-140)] NASA Advisory Council; Meeting... Space Administration announces a meeting of the NASA Advisory Council (NAC). DATES: Wednesday, December...., Local Time. ADDRESSES: NASA Kennedy Space Center, Headquarters Building, Room 2201, Kennedy Space Center...

North American X-15 model tested in 300MPH Low Speed 7x10 Tunnel

NASA Image and Video Library

1958-09-07

A one-twentieth scale model of the X-15 originally suspended beneath the wing of a B-52 is observed by a scientist of the National Aeronautics and Space Administration (NASA) as it leaves the bomber model in tests to determine the release characteristics and drop motion of the research airplane. Caption: The aerodynamics of air launching the North American X-15 being investigated in the 300MPH Low Speed 7x10 Tunnel, about 1957. Photograph published in Engineer in Charge: A History of the Langley Aeronautical Laboratory, 1917-1958 by James R. Hansen. Page 366. Photograph also published in Sixty Years of Aeronautical Research 1917-1977 By David A. Anderton. A NASA publication. Page 49.

KSC01pp0681

NASA Image and Video Library

2001-04-03

KENNEDY SPACE CENTER, FLA. -- A large adult manatee requires many helpers to lift it out of the van that brought it from Sea World for release into the Banana River. The site is on the north side of the NASA Causeway, near Kennedy Space Center. A calf was also released at the site. Manatees are frequently seen in the waters around Kennedy Space Center, which is surrounded by the Merritt Island National Wildlife Refuge

Novel therapeutic approach for pulmonary emphysema using gelatin microspheres releasing basic fibroblast growth factor in a canine model.

PubMed

Chang, Sung Soo; Yokomise, Hiroyasu; Matsuura, Natsumi; Gotoh, Masashi; Tabata, Yasuhiko

2014-08-01

The prognosis of patients with emphysema is poor as there is no truly effective treatment. Our previous study showed that the alveolar space was smaller and the microvessel density was higher in a canine emphysema model after the intrapulmonary arterial administration of gelatin microspheres slowly releasing basic fibroblast growth factor (bFGF-GMS). In the present study, we evaluated the functional effect of injecting bFGF-GMS via the pulmonary artery in this canine pulmonary emphysema model. Using the porcine pancreatic elastase (PPE)-induced total emphysema model, we approximated the value of lung compliance with a Power Lab System, and performed blood gas analysis in a control group, a total emphysema group, and a bFGF group in which bFGF-GMS were injected toward the whole pulmonary artery via the femoral vein. Each group comprised five dogs. Lung compliance was higher in the total emphysema group than in the control group (p = 0.031), and the bFGF group showed no significant improvement of lung compliance vs. the total emphysema group (p = 0.112). PaO2 (partial pressure of oxygen in arterial blood) was improved by administering bFGF-GMS in the total emphysema model (p = 0.027). In the canine total emphysema model, blood gas parameters were improved by the whole pulmonary arterial administration of bFGF-GMS. This method has the potential to be an effective novel therapy for pulmonary emphysema.

Releases: Is There Still a Place for Their Use by Colleges and Universities?

ERIC Educational Resources Information Center

Connell, Mary Ann; Savage, Frederick G.

2003-01-01

Analyzes the legal principles, facts, and circumstances that govern decisions of courts regarding the validity of written releases, and provides practical advice to higher education lawyers and administrators as they evaluate the utility of releases and seek to maximize their benefit. (EV)

50 CFR 635.26 - Catch and release.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Catch and release. 635.26 Section 635.26 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE ATLANTIC HIGHLY MIGRATORY SPECIES Management Measures § 635.26 Catch and release. (a...

28 CFR 301.317 - Medical treatment following release.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Medical treatment following release. 301... INMATE ACCIDENT COMPENSATION Compensation for Work-Related Physical Impairment or Death § 301.317 Medical treatment following release. Federal Prison lndustries, Inc., may not pay the cost of medical, hospital...

28 CFR 301.317 - Medical treatment following release.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Medical treatment following release. 301... INMATE ACCIDENT COMPENSATION Compensation for Work-Related Physical Impairment or Death § 301.317 Medical treatment following release. Federal Prison lndustries, Inc., may not pay the cost of medical, hospital...

28 CFR 301.317 - Medical treatment following release.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Medical treatment following release. 301... INMATE ACCIDENT COMPENSATION Compensation for Work-Related Physical Impairment or Death § 301.317 Medical treatment following release. Federal Prison lndustries, Inc., may not pay the cost of medical, hospital...

21 CFR 181.28 - Release agents.

Code of Federal Regulations, 2014 CFR

2014-04-01

... classified as release agents, when migrating from food-packaging material shall include: Dimethylpolysiloxane... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Release agents. 181.28 Section 181.28 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) PRIOR-SANCTIONED...

49 CFR 236.16 - Electric lock, main track releasing circuit.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Electric lock, main track releasing circuit. 236... RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RULES, STANDARDS, AND INSTRUCTIONS GOVERNING THE... Rules and Instructions: All Systems General § 236.16 Electric lock, main track releasing circuit. When...

77 FR 6985 - General Services Administration Acquisition Regulation; Reinstatement of Coverage Pertaining to...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-10

... Claims, for releases of claims under construction and building service contracts, was inadvertently... the release of claims under construction and building service contracts. At this time, consideration... for releases of claims under construction and building service contracts, was inadvertently deleted as...

Comparison of the efficacy and safety profile of morning administration of controlled-release simvastatin versus evening administration of immediate-release simvastatin in chronic kidney disease patients with dyslipidemia.

PubMed

Yi, Yong Jin; Kim, Hyo Jin; Jo, Sang Kyung; Kim, Sung Gyun; Song, Young Rim; Chung, Wookyung; Han, Kum Hyun; Lee, Chang Hwa; Hwang, Young-Hwan; Oh, Kook-Hwan

2014-08-01

Evening administration of the conventional immediate-release (IR) formulation of simvastatin is recommended because of its short half-life (1.9 hours). In a healthy population, morning administration of a controlled-release (CR) formulation of simvastatin was shown to have equivalent lipid-lowering efficacy and a safety profile similar to that of evening doses of IR simvastatin. The present study aimed to verify noninferiority and to compare the safety of morning administration of CR simvastatin with that of evening administration of IR simvastatin in patients with chronic kidney disease (CKD) who have dyslipidemia. The present study was a prospective, multicenter, double-blind, Phase IV trial with an active comparator. We randomly assigned 122 patients with CKD and dyslipidemia to 1 of 2 drug administration groups: morning administration of CR simvastatin 20 mg (test group) and evening administration of IR simvastatin 20 mg (control group). After 8 weeks, the treatment outcomes and adverse effects of the 2 treatments were compared. The mean (SD) percentage of change in serum LDL-C at the end of treatment was -35.1% (15.7%) for the test group and -35.6% (14.6%) for the control group. The difference between the 2 groups was not significant (P = 0.858). The 95% CI of the difference in the percentage of change of LDL-C between the test and control groups was -6.0 to 5.0. There was no difference in the percentage of change of total cholesterol (-24.3% [12.5%] vs -26.5% [12.0%], P = 0.317), triglyceride (-10.6% [35.1%] vs -12.4% [33.2%], P = 0.575) and HDL-C (10.2% [20.7%] vs 4.5% [11.4%], P = 0.064). Treatment-related adverse events were similar in both groups (10 events in the test group vs 8 events in the control group, P = 0.691). The efficacy of morning administration of CR simvastatin was noninferior to evening administration of IR simvastatin in patients with CKD. Furthermore, the safety profile analysis showed no significant difference between the 2 treatments. Morning administration of CR simvastatin is expected to increase patient compliance and therefore better control of dyslipidemia in CKD patients. Copyright © 2014 The Authors. Published by EM Inc USA.. All rights reserved.

78 FR 65006 - National Space-Based Positioning, Navigation, and Timing (PNT) Advisory Board; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-30

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 13-125] National Space-Based Positioning, Navigation, and Timing (PNT) Advisory Board; Meeting AGENCY: National Aeronautics and Space Administration..., Public Law 92-463, as amended, and the President's 2004 U.S. Space-Based Positioning, Navigation, and...

How controlled release technology can aid gene delivery.

PubMed

Jo, Jun-Ichiro; Tabata, Yasuhiko

2015-01-01

Many types of gene delivery systems have been developed to enhance the level of gene expression. Controlled release technology is a feasible gene delivery system which enables genes to extend the expression duration by maintaining and releasing them at the injection site in a controlled manner. This technology can reduce the adverse effects by the bolus dose administration and avoid the repeated administration. Biodegradable biomaterials are useful as materials for the controlled release-based gene delivery technology and various biodegradable biomaterials have been developed. Controlled release-based gene delivery plays a critical role in a conventional gene therapy and genetic engineering. In the gene therapy, the therapeutic gene is released from biodegradable biomaterial matrices around the tissue to be treated. On the other hand, the intracellular controlled release of gene from the sub-micro-sized matrices is required for genetic engineering. Genetic engineering is feasible for cell transplantation as well as research of stem cells biology and medicine. DNA hydrogel containing a sequence of therapeutic gene and the exosome including the individual specific nucleic acids may become candidates for controlled release carriers. Technologies to deliver genes to cell aggregates will play an important role in the promotion of regenerative research and therapy.

Preparation of gastro-resistant pellets containing chitosan microspheres for improvement of oral didanosine bioavailability

PubMed Central

Severino, Patrícia; de Oliveira, George G.G.; Ferraz, Humberto G.; Souto, Eliana B.; Santana, Maria H.A.

2012-01-01

The purpose of this work was to introduce a new concept of coated pellets containing chitosan microspheres loaded with didadosine for oral administration, aiming at reducing the frequency of administration and improving the bioavailability by a suitable release profile. Chitosan microspheres were produced under fluidized bed, followed by extrusion and spheronization to obtain pellets with a mean diameter of about 1 mm. The pellets were then coated with Kollidon® VA64 and Kollicoat® MAE100P in water dispersion to depict a sustained release profile. Conventional hard gelatine capsules were loaded with these pellets and tested in vitro for their release profile of didadosine. Dissolution testing confirmed that chitosan microsphere pellets provides appropriate sustained release up to 2 h behavior for didanosine. PMID:29403741

Effect of acute and chronic MK-801 administration on extracellular glutamate and ascorbic acid release in the prefrontal cortex of freely moving mice on line with open-field behavior.

PubMed

Zuo, Dai-Ying; Zhang, Ya-Hong; Cao, Yue; Wu, Chun-Fu; Tanaka, Masatoshi; Wu, Ying-Liang

2006-04-04

The present study was designed to investigate the effects of acute and chronic administration of MK-801 (0.6 mg/kg), a noncompetitive NMDA-receptor antagonist on extracellular glutamate (Glu) and ascorbic acid (AA) release in the prefrontal cortex (PFC) of freely moving mice using in vivo microdialysis with open-field behavior. In line with earlier studies, acute administration of MK-801 induced an increase of Glu in the PFC. We also observed single MK-801 treatment increased AA release in the PFC. In addition, our results indicated that the basal AA levels in the PFC after MK-801 administration for 7 consecutive days were significantly decreased, and basal Glu levels also had a decreased tendency. After chronic administration (0.6 mg/kg, 7 days), MK-801 (0.6 mg/kg) challenge significantly decreased dialysate levels of AA and Glu. Our study also found that both acute and chronic administration of MK-801 induced hyperactivity in mice, but the intensity of acute administration was more than that of chronic administration. Furthermore, in all acute treatment mice, individual changes in Glu dialysate concentrations and the numbers of locomotion were positively correlated. In conclusion, this study may provide new evidence that a single MK-801 administration induces increases of dialysate AA and Glu concentrations in the PFC of freely moving mice, which are opposite to those induced by repeated MK-801 administration, with an unknown mechanism. Our results suggested that redox-response might play an important role in the model of schizophrenic symptoms induced by MK-801.

14 CFR 406.111 - Signing documents.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Signing documents. 406.111 Section 406.111 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURE INVESTIGATIONS, ENFORCEMENT, AND ADMINISTRATIVE REVIEW Rules of Practice in FAA Space...

14 CFR 406.111 - Signing documents.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Signing documents. 406.111 Section 406.111 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURE INVESTIGATIONS, ENFORCEMENT, AND ADMINISTRATIVE REVIEW Rules of Practice in FAA Space...

Address by James C. Fletcher, Administrator National Aeronautics and Space Administration at the National Academy of Engineering, Washington, D.C., 10 November 1975

NASA Technical Reports Server (NTRS)

1975-01-01

Future plans and programs of the space agency are discussed. Topics discussed include solar energy, space stations, planetary exploration, interstellar exploration, the space shuttles, and satellites.

Ovarian hyperstimulation syndrome following the sole administration of injectable gonadotropin-releasing hormone agonist (triptorelin) for the pituitary down-regulation and in vitro fertilization treatment: report of two cases.

PubMed

Qublan, Hussein S; Beni-Merei, Zakarya; Megdadi, Mohamad; Al-Quraan, Gassan

2009-02-01

This report is to illustrate two cases of ovarian hyperstimulation syndrome following the sole administration of injectable mid-luteal gonadotropin-releasing hormone agonists (triptorelin) for pituitary down-regulation. Both women underwent egg retrieval, and despite the transfer of good quality embryos, no pregnancy was achieved. The possible mechanism and management of the condition were discussed.

76 FR 42715 - Quarantine Release Errors in Blood Establishments; Public Workshop

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-19

... Committee on Blood Safety and Availability (the Committee) met to discuss the current FDA blood donor...] Quarantine Release Errors in Blood Establishments; Public Workshop AGENCY: Food and Drug Administration, HHS... entitled: ``Quarantine Release Errors in Blood Establishments.'' The purpose of this public workshop is to...

12 CFR 793.8 - Release.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Release. 793.8 Section 793.8 Banks and Banking... ADMINISTRATION TORT CLAIMS AGAINST THE GOVERNMENT Procedures § 793.8 Release. Acceptance by the claimant, his agent or legal representative, of any award, compromise or settlement made hereunder, shall be final and...

78 FR 6401 - Public Notice for Release of Aeronautical Property at the Wilkes-Barre/Scranton International...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-30

... listed above. SUPPLEMENTARY INFORMATION: The FAA invites public comment on the release of land and right... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Public Notice for Release of Aeronautical Property at the Wilkes- Barre/Scranton International Airport (AVP), Avoca, PA AGENCY: Federal...

75 FR 12329 - Release of Waybill Data

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-15

... Economics, Environmental Analysis, and Administration. The waybill sample contains confidential railroad and... the Director of the Board's Office of Economics, Environmental Analysis, and Administration within 14...

Improved Bioavailability of Levodopa Using Floatable Spray-Coated Microcapsules for the Management of Parkinson's Disease.

PubMed

Baek, Jong-Suep; Tee, Jie Kai; Pang, Yi Yun; Tan, Ern Yu; Lim, Kah Leong; Ho, Han Kiat; Loo, Say Chye Joachim

2018-06-01

Oral administration of levodopa (LD) is the gold standard in managing Parkinson's disease (PD). Although LD is the most effective drug in treating PD, chronic administration of LD induces levodopa-induced dyskinesia. A continuous and sustained provision of LD to the brain could, therefore, reduce peak-dose dyskinesia. In commercial oral formulations, LD is co-administrated with an AADC inhibitor (carbidopa) and a COMT inhibitor (entacapone) to enhance its bioavailability. Nevertheless, patients are known to take up to five tablets a day because of poor sustained-releasing capabilities that lead to fluctuations in plasma concentrations. To achieve a prolonged release of LD with the aim of improving its bioavailability, floatable spray-coated microcapsules containing all three PD drugs were developed. This gastro-retentive delivery system showed sustained release of all PD drugs, at similar release kinetics. Pharmacokinetics study was conducted and this newly developed formulation showed a more plateaued delivery of LD that is void of the plasma concentration fluctuations observed for the control (commercial formulation). At the same time, measurements of LD and dopamine of mice administered with this formulation showed enhanced bioavailability of LD. This study highlights a floatable, sustained-releasing delivery system in achieving improved pharmacokinetics data compared to a commercial formulation.

77 FR 58607 - Office of Commercial Space Transportation Safety Approval Performance Criteria

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-21

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Office of Commercial Space...), FAA Office of Commercial Space Transportation (AST), 800 Independence Avenue SW., Room 331, Washington... September 17, 2012. George C. Nield, Associate Administrator for Commercial Space Transportation. [FR Doc...

77 FR 52696 - Federal Acquisition Regulation; Information Collection; Drug-Free Workplace (FAR 52.223-6)

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-30

... DEPARTMENT OF DEFENSE GENERAL SERVICES ADMINISTRATION NATIONAL AERONAUTICS AND SPACE... Services Administration (GSA), and National Aeronautics and Space Administration (NASA). ACTION: Notice of... Data [[Page 52697

14 CFR 125.359 - Flight release under VFR.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Flight release under VFR. 125.359 Section...,000 POUNDS OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Flight Release Rules § 125.359 Flight release under VFR. No person may release an airplane for VFR operation unless the ceiling and...

14 CFR 125.359 - Flight release under VFR.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Flight release under VFR. 125.359 Section...,000 POUNDS OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Flight Release Rules § 125.359 Flight release under VFR. No person may release an airplane for VFR operation unless the ceiling and...

14 CFR 125.359 - Flight release under VFR.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Flight release under VFR. 125.359 Section...,000 POUNDS OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Flight Release Rules § 125.359 Flight release under VFR. No person may release an airplane for VFR operation unless the ceiling and...

Memorandum of Agreement Among Department of Defense, Federal Aviation Administration and National Aeronautics and Space Administration on Federal Interaction With Launch Site Operators

DOT National Transportation Integrated Search

1997-01-01

This Memorandum of Agreement (Agreement) explains the respective roles and : responsibilities of the Department of Defense, the Federal Aviation : Administration, and the National Aeronautics and Space Administration, : in their interactions with lau...

Role of synbiotics in polysaccharide assisted colon targeted microspheres of mesalamine for the treatment of ulcerative colitis.

PubMed

Kaur, Rupinderjeet; Gulati, Monica; Singh, Sachin Kumar

2017-02-01

The present study explains the effect of concomitant administration of synbiotics with the polysaccharide based colon targeted delivery system. As the gut microflora get deranged on administration of mesalamine, drug release from such delivery systems is expected to be jeopardised because the release trigger is dependent solely on the colonic microbiota. To overcome this limitation, mesalamine was formulated as microspheres with guar gum and xanthan gum (prebiotics). These were combined with probiotics containing Lactobacillus acidophilus, L. rhamnosus, Bifidobacterium longumand Saccharomyces boulardi. Dissolution studies of the prepared formulation conducted in simulated colonic fluid clearly demonstrated its superiority over the marketed, delayed release dosage forms of mesalamine. The therapeutic benefit of the concomitant administration of synbiotic with mesalamine was evidenced by the comparative evaluation of faecal contents, weight gain trend and histopathological studies conducted in rats. The results suggest that co-administration of synbiotics with mesalamine can be used as a convenient methodology to achieve efficient and cost-effective targeting of the drug to colon. Copyright © 2016 Elsevier B.V. All rights reserved.

14 CFR § 1214.1707 - Media and public inquiries.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Media and public inquiries. § 1214.1707 Section § 1214.1707 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Space Flight Participants § 1214.1707 Media and public inquiries. (a) The Associate Administrator for...

Preparation and pharmaceutical evaluation of new sustained-release capsule including starch-sponge matrix (SSM).

PubMed

Shibata, Nobuhito; Nishumura, Asako; Naruhashi, Kazumasa; Nakao, Yurie; Miura, Rieko

2010-05-01

The focus of current study was to demonstrate a new sustained-release capsule including starch-sponge matrix (SSM) and to investigate how the pharmaceutical properties of SSM affect the drug release or its pharmacokinetic properties. Three representative drugs (uranine [UN], indomethacin [IMC] and nifedipine [NFP]) with different physicochemical properties (LogP(ow): 0.10, 1.18 and 3.23, respectively) were selected as model drugs. Model drug was dispersioned in pastelike cornstarch (starch glue) after heating 2.0-3.0% cornstarch suspension with electromagnetic wave at 2450 MHz (700 W) for l min. Then the drug mixture was encapsulated into a gratin capsule by a syringe, and the SSM including drug was prepared by means of a freeze-dried method. Essentially, drug-free SSM has a porous and netlike structure, and the distribution aspect of model drugs in the SSM depends on physicochemical properties between cornstarch glue and drugs. UN with much lower lipophilicity exists in continues phase of SSM, and IMC or NFP with a moderate or a higher lipophilicity exist in continues phase or porous space of the SSM. In the in vitro dissolution study, the release rate of drug from the SSM was mainly dependent on the lipophilicities of drugs, showing a rank order of the release rate of UN>IMC>NFP. In addition, the in vitro release rate for each drug was well regulated by changing the initial concentration of cornstarch suspension. In vivo absorption studies after intraduodenal administration of SSM capsule including model drug revealed that the sustained-release effects also could be regulated by the initial concentration of starch suspension. Moreover, the sustained-release effect of SSM capsule was enhanced with an increase in the lipophilicity of drug, and local-residential and mucoadhesive properties of SSM in the intestine provided stable supply of drugs from the SSM. The SSM capsule we developed here shows promising results as an oral drug delivery system for sustained-release regulation or target specificity. 2009 Elsevier Masson SAS. All rights reserved.

Development of Intra-knee Joint Sustained-Release Gel Formulation and Evaluation of Its Pharmacological Efficiency in Rats.

PubMed

Noda, Takehiro; Okuda, Tomoyuki; Ban, Kousuke; Mizuno, Ryota; Tagami, Tatsuaki; Ozeki, Tetsuya; Okamoto, Hirokazu

2017-06-01

In the development of a drug for intra-articular administration, a sustained-release formulation is desirable since it is difficult to sustain the effects of conventional injections due to fast drug leakage from the joint cavity. In this study, we prepared sustained release gel formulations for intra-articular administration containing indocyanine green (ICG) as a model drug to follow its fate after intra-articular administration in rats with in-vivo imaging system (IVIS). ICG administered as an aqueous solution leaked from the joint cavity in a short time and was excreted out of the body within a day. On the other hand, ICG in the sustained-release formulations was retained and released in the joint cavity for a week. Next, we prepared a sustained-release formulation with hyaluronic acid (HA) as the gel base containing a pain-relief drug (Drug A). We had administered it and other formulations into the rat knee where we injected bradykinin to evaluate their walking distance after 1 and 3 d. The effect of an aqueous solution of Drug A disappeared on day 3. The HA gel formulation without Drug A was more effective than the aqueous solution. The HA gel formulation with Drug A was the most effective; the walking distance was about 85% of the baseline on day 3. This study showed that the gel formulations were effective to sustain the release of a drug in the knee joint, and that the combination of a pain-relief drug with HA gel was effective to improve the mobility of the acute pain model rats.

77 FR 40069 - Single-Ingredient, Immediate-Release Drug Products Containing Oxycodone for Oral Administration...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-06

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2012-N-0563... Labeled for Human Use; Enforcement Action Dates AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA or Agency) is announcing its intention to take enforcement...

Guide to Mathematics Released Items: Understanding Scoring. 2015

ERIC Educational Resources Information Center

Partnership for Assessment of Readiness for College and Careers, 2015

2015-01-01

The 2014-2015 administrations of the PARCC assessment included two separate test administration windows: the Performance-Based Assessment (PBA) and the End-of-Year (EOY), both of which were administered in paper-based and computer-based formats. The first window was for administration of the PBA, and the second window was for the administration of…

NASA Deputy Administrator Tours Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

1968-01-01

Pictured from the left, in the Saturn I mockup, are: William Brooksbank, Marshall Space Flight Center (MSFC) Propulsion and Vehicle Engineering Laboratory; Dr. Thomas O. Paine, Deputy Administrator of the National Aeronautics and Space Administration (NASA); Dr. Wernher von Braun, MSFC director; Colonel Clare F. Farley, executive officer of the Office of the Administrator; and Charles J. Donlan, newly appointed deputy associate administrator for Manned Space Flight, technical. The party examined an ordinary man's shoe (held by Paine) outfitted for use in the Saturn I Workshop. The shoe had a unique fastener built into the sole to allow an astronaut to move about the workshop floor and to remain in one position if he desired. Dr. Paine and his party indulged in a two-day tour at the Marshall Space Flight Center getting acquainted with Marshall personnel and programs. It was Paine's first visit to the center since assuming the NASA post on February 1, 1968.

14 CFR 1203b.109 - Disclaimer.

Code of Federal Regulations, 2013 CFR

2013-01-01

... otherwise lawful activities of security force personnel or the National Aeronautics and Space Administration. ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Disclaimer. 1203b.109 Section 1203b.109 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SECURITY PROGRAMS; ARREST AUTHORITY AND...

14 CFR 1203b.109 - Disclaimer.

Code of Federal Regulations, 2011 CFR

2011-01-01

... otherwise lawful activities of security force personnel or the National Aeronautics and Space Administration. ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Disclaimer. 1203b.109 Section 1203b.109 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SECURITY PROGRAMS; ARREST AUTHORITY AND...

14 CFR 1261.101 - Claimants.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Aeronautics and Space Administration; (2) A member of the uniformed services (Army, Navy, Air Force, Marine... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Claimants. 1261.101 Section 1261.101 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROCESSING OF MONETARY CLAIMS (GENERAL...

14 CFR 1203b.109 - Disclaimer.

Code of Federal Regulations, 2010 CFR

2010-01-01

... otherwise lawful activities of security force personnel or the National Aeronautics and Space Administration. ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Disclaimer. 1203b.109 Section 1203b.109 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SECURITY PROGRAMS; ARREST AUTHORITY AND...

14 CFR 1261.101 - Claimants.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Aeronautics and Space Administration; (2) A member of the uniformed services (Army, Navy, Air Force, Marine... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Claimants. 1261.101 Section 1261.101 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROCESSING OF MONETARY CLAIMS (GENERAL...

14 CFR 1203b.109 - Disclaimer.

Code of Federal Regulations, 2012 CFR

2012-01-01

... otherwise lawful activities of security force personnel or the National Aeronautics and Space Administration. ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Disclaimer. 1203b.109 Section 1203b.109 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SECURITY PROGRAMS; ARREST AUTHORITY AND...

14 CFR 1261.101 - Claimants.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Aeronautics and Space Administration; (2) A member of the uniformed services (Army, Navy, Air Force, Marine... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Claimants. 1261.101 Section 1261.101 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROCESSING OF MONETARY CLAIMS (GENERAL...

14 CFR 1261.101 - Claimants.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Aeronautics and Space Administration; (2) A member of the uniformed services (Army, Navy, Air Force, Marine... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Claimants. 1261.101 Section 1261.101 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROCESSING OF MONETARY CLAIMS (GENERAL...

77 FR 67028 - NASA Advisory Council; Commercial Space Committee; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-08

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 12-093] NASA Advisory Council; Commercial..., the National Aeronautics and Space Administration (NASA) announces a meeting of the Commercial Space Committee of the NASA Advisory Council (NAC). This Committee reports to the NAC. The [[Page 67029