41 CFR 102-37.130 - What are a SASP's responsibilities in the donation of surplus property?

Code of Federal Regulations, 2013 CFR

2013-07-01

... responsibilities in the donation of surplus property? 102-37.130 Section 102-37.130 Public Contracts and Property... PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY State Agency for Surplus Property (SASP) § 102-37.130 What are a SASP's responsibilities in the donation of surplus property? As a SASP, your...

Quercetin and rutin ameliorates sulphasalazine-induced spermiotoxicity, alterations in reproductive hormones and steroidogenic enzyme imbalance in rats.

PubMed

Osawe, S O; Farombi, E O

2018-06-01

Certain dietary flavonoids exhibit protective potentials against drug-induced male reproductive toxicities. We investigated the protective effects of quercetin and rutin on sulphasalazine-induced alterations in steroidogenic enzyme activity, hormone profile and spermiotoxicity in rats. Sulphasalazine (SASP, 600 mg/kg bw) was administered alone or in combination with quercetin (20 mg/kg bw) or rutin (10 mg/kg bw) for 14 days. SASP treatment significantly increased relative weights of the epididymis and seminal vesicles. Also, testicular and epididymal sperm numbers (TSN, ESN), motility, daily sperm production (DSP) and acrosome reaction (AR) significantly decreased. SASP altered plasma testosterone, luteinising hormone (LH) and follicle-stimulating hormone (FSH) levels while testicular cholesterol levels, 3β-hydroxysteroid dehydrogenase (3β-HSD) and 17β-hydroxysteroid dehydrogenase (17β-HSD) activities were decreased. Elevated malondialdehyde levels and concomitant decrease in reduced glutathione, glutathione-S-transferase, peroxidase and superoxide dismutase activities were evident in testis and epididymis of SASP-treated rats. Quercetin or rutin co-treatment with SASP significantly reversed organ weights, preserved sperm integrity, restored plasma hormone levels and increased cholesterol levels, 3β-HSD and 17β-HSD activities in testis. Both flavonoids also prevented oxidative stress in testis and epididymis of SASP-treated rats. Quercetin and rutin protect against the negative effects of SASP treatment on reproductive capacity in male rats. © 2018 Blackwell Verlag GmbH.

41 CFR 102-37.175 - How does a SASP find out what property is potentially available for donation?

Code of Federal Regulations, 2010 CFR

2010-07-01

... what property is potentially available for donation? 102-37.175 Section 102-37.175 Public Contracts and... REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY State Agency for Surplus Property (SASP... available for donation? A SASP may conduct onsite screening at various Federal facilities, contact or submit...

41 CFR 102-37.175 - How does a SASP find out what property is potentially available for donation?

Code of Federal Regulations, 2013 CFR

2013-07-01

... what property is potentially available for donation? 102-37.175 Section 102-37.175 Public Contracts and... REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY State Agency for Surplus Property (SASP... available for donation? A SASP may conduct onsite screening at various Federal facilities, contact or submit...

41 CFR 102-37.175 - How does a SASP find out what property is potentially available for donation?

Code of Federal Regulations, 2011 CFR

2011-01-01

... what property is potentially available for donation? 102-37.175 Section 102-37.175 Public Contracts and... REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY State Agency for Surplus Property (SASP... available for donation? A SASP may conduct onsite screening at various Federal facilities, contact or submit...

41 CFR 102-37.175 - How does a SASP find out what property is potentially available for donation?

Code of Federal Regulations, 2014 CFR

2014-01-01

... what property is potentially available for donation? 102-37.175 Section 102-37.175 Public Contracts and... REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY State Agency for Surplus Property (SASP... available for donation? A SASP may conduct onsite screening at various Federal facilities, contact or submit...

41 CFR 102-37.175 - How does a SASP find out what property is potentially available for donation?

Code of Federal Regulations, 2012 CFR

2012-01-01

... what property is potentially available for donation? 102-37.175 Section 102-37.175 Public Contracts and... REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY State Agency for Surplus Property (SASP... available for donation? A SASP may conduct onsite screening at various Federal facilities, contact or submit...

41 CFR 102-37.360 - What reports must a SASP provide to GSA?

Code of Federal Regulations, 2014 CFR

2014-01-01

... authority to transfer surplus personal property for donation and to report to the Congress on the status and... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false What reports must a SASP... SURPLUS PERSONAL PROPERTY State Agency for Surplus Property (SASP) Reports § 102-37.360 What reports must...

41 CFR 102-37.360 - What reports must a SASP provide to GSA?

Code of Federal Regulations, 2010 CFR

2010-07-01

... authority to transfer surplus personal property for donation and to report to the Congress on the status and... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What reports must a SASP... SURPLUS PERSONAL PROPERTY State Agency for Surplus Property (SASP) Reports § 102-37.360 What reports must...

41 CFR 102-37.360 - What reports must a SASP provide to GSA?

Code of Federal Regulations, 2013 CFR

2013-07-01

... authority to transfer surplus personal property for donation and to report to the Congress on the status and... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false What reports must a SASP... SURPLUS PERSONAL PROPERTY State Agency for Surplus Property (SASP) Reports § 102-37.360 What reports must...

41 CFR 102-37.360 - What reports must a SASP provide to GSA?

Code of Federal Regulations, 2012 CFR

2012-01-01

... authority to transfer surplus personal property for donation and to report to the Congress on the status and... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false What reports must a SASP... SURPLUS PERSONAL PROPERTY State Agency for Surplus Property (SASP) Reports § 102-37.360 What reports must...

[Pharmacokinetics of salazosulfapyridine in a hemodialysis patient].

PubMed

Akiyama, Yuji; Fujimaki, Toshihisa; Sakurai, Yusei

2003-06-01

The patient was a 62-year-old female. Total gastrectomy was performed due to gastric ulcer in 1969. She was diagnosed as rheumatoid arthritis (RA) in 1985 and was developed to amyloidosis in 1991. She was started on hemodialysis (HD) for chronic renal failure in 1996. In 1998, her arthralgia was aggravated, and 100 mg/day of bucillamine was administered on the day of HD. Her arthralgia persisted, and switching to salazosulfapyridine (SASP) was considered. As there were no standards and no reports for the use of SASP in HD patients, we examined the pharmacokinetics of SASP and its metabolites, and compared our patient with the results of phase one study in normal subjects in Japan. In this case, the blood concentration of SASP was similar to that in healthy controls after single administration of 500 mg of SASP on the day of non-HD, while the concentration of sulfapyridine (SP) was higher than that in healthy donors. However, the blood concentrations of SASP, SP, and N4-acetyl-SP (AcSP) at 24 hours after administration were similar to those obtained in healthy men. SASP was not dialyzed, while about half of SP and AcSP, were dialyzed. In a five-day consecutive administration study also, the blood concentrations of these compounds on Day 5 were similar to those of phase one study, suggesting no accumulation. No adverse drug reaction was observed. As this case had the past history of total gastrectomy and amyloidosis, it is possible that this result is influenced by the factors. Therefore it is necessary to examine pharmacokinetics of SASP and its metabolites beforehand when administering this agent to other HD/RA patients.

41 CFR 102-37.235 - What type of information must a SASP provide when requesting surplus property for cannibalization?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false What type of information must a SASP provide when requesting surplus property for cannibalization? 102-37.235 Section 102-37.235... Surplus Property (SASP) Justifying Special Transfer Requests § 102-37.235 What type of information must a...

41 CFR 102-37.235 - What type of information must a SASP provide when requesting surplus property for cannibalization?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What type of information must a SASP provide when requesting surplus property for cannibalization? 102-37.235 Section 102-37.235... Surplus Property (SASP) Justifying Special Transfer Requests § 102-37.235 What type of information must a...

41 CFR 102-37.235 - What type of information must a SASP provide when requesting surplus property for cannibalization?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What type of information must a SASP provide when requesting surplus property for cannibalization? 102-37.235 Section 102-37.235... Surplus Property (SASP) Justifying Special Transfer Requests § 102-37.235 What type of information must a...

41 CFR 102-37.235 - What type of information must a SASP provide when requesting surplus property for cannibalization?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false What type of information must a SASP provide when requesting surplus property for cannibalization? 102-37.235 Section 102-37.235... Surplus Property (SASP) Justifying Special Transfer Requests § 102-37.235 What type of information must a...

41 CFR 102-37.235 - What type of information must a SASP provide when requesting surplus property for cannibalization?

Code of Federal Regulations, 2014 CFR

2014-01-01

... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false What type of information must a SASP provide when requesting surplus property for cannibalization? 102-37.235 Section 102-37.235... Surplus Property (SASP) Justifying Special Transfer Requests § 102-37.235 What type of information must a...

Different small, acid-soluble proteins of the alpha/beta type have interchangeable roles in the heat and UV radiation resistance of Bacillus subtilis spores.

PubMed Central

Mason, J M; Setlow, P

1987-01-01

Spores of Bacillus subtilis strains which carry deletion mutations in one gene (sspA) or two genes (sspA and sspB) which code for major alpha/beta-type small, acid-soluble spore proteins (SASP) are known to be much more sensitive to heat and UV radiation than wild-type spores. This heat- and UV-sensitive phenotype was cured completely or in part by introduction into these mutant strains of one or more copies of the sspA or sspB genes themselves; multiple copies of the B. subtilis sspD gene, which codes for a minor alpha/beta-type SASP; or multiple copies of the SASP-C gene, which codes for a major alpha/beta-type SASP of Bacillus megaterium. These findings suggest that alpha/beta-type SASP play interchangeable roles in the heat and UV radiation resistance of bacterial spores. Images PMID:3112127

41 CFR 102-37.195 - Does a SASP have to have a donee in mind to request surplus property?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Does a SASP have to have a donee in mind to request surplus property? 102-37.195 Section 102-37.195 Public Contracts and...) Screening and Requesting Property § 102-37.195 Does a SASP have to have a donee in mind to request surplus...

41 CFR 102-37.195 - Does a SASP have to have a donee in mind to request surplus property?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Does a SASP have to have a donee in mind to request surplus property? 102-37.195 Section 102-37.195 Public Contracts and...) Screening and Requesting Property § 102-37.195 Does a SASP have to have a donee in mind to request surplus...

41 CFR 102-37.195 - Does a SASP have to have a donee in mind to request surplus property?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false Does a SASP have to have a donee in mind to request surplus property? 102-37.195 Section 102-37.195 Public Contracts and...) Screening and Requesting Property § 102-37.195 Does a SASP have to have a donee in mind to request surplus...

41 CFR 102-37.195 - Does a SASP have to have a donee in mind to request surplus property?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Does a SASP have to have a donee in mind to request surplus property? 102-37.195 Section 102-37.195 Public Contracts and...) Screening and Requesting Property § 102-37.195 Does a SASP have to have a donee in mind to request surplus...

41 CFR 102-37.195 - Does a SASP have to have a donee in mind to request surplus property?

Code of Federal Regulations, 2014 CFR

2014-01-01

... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false Does a SASP have to have a donee in mind to request surplus property? 102-37.195 Section 102-37.195 Public Contracts and...) Screening and Requesting Property § 102-37.195 Does a SASP have to have a donee in mind to request surplus...

41 CFR 102-37.410 - What must a SASP do if a donee fails to maintain its eligibility status?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What must a SASP do if a donee fails to maintain its eligibility status? 102-37.410 Section 102-37.410 Public Contracts and... SASP do if a donee fails to maintain its eligibility status? If you determine that a donee has failed...

41 CFR 102-37.410 - What must a SASP do if a donee fails to maintain its eligibility status?

Code of Federal Regulations, 2014 CFR

2014-01-01

... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false What must a SASP do if a donee fails to maintain its eligibility status? 102-37.410 Section 102-37.410 Public Contracts and... SASP do if a donee fails to maintain its eligibility status? If you determine that a donee has failed...

41 CFR 102-37.410 - What must a SASP do if a donee fails to maintain its eligibility status?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false What must a SASP do if a donee fails to maintain its eligibility status? 102-37.410 Section 102-37.410 Public Contracts and... SASP do if a donee fails to maintain its eligibility status? If you determine that a donee has failed...

Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells.

PubMed

Perrott, Kevin M; Wiley, Christopher D; Desprez, Pierre-Yves; Campisi, Judith

2017-04-01

Apigenin (4',5,7,-trihydroxyflavone) is a flavonoid found in certain herbs, fruits, and vegetables. Apigenin can attenuate inflammation, which is associated with many chronic diseases of aging. Senescent cells-stressed cells that accumulate with age in mammals-display a pro-inflammatory senescence-associated secretory phenotype (SASP) that can drive or exacerbate several age-related pathologies, including cancer. Flavonoids, including apigenin, were recently shown to reduce the SASP of a human fibroblast strain induced to senesce by bleomycin. Here, we confirm that apigenin suppresses the SASP in three human fibroblast strains induced to senesce by ionizing radiation, constitutive MAPK (mitogen-activated protein kinase) signaling, oncogenic RAS, or replicative exhaustion. Apigenin suppressed the SASP in part by suppressing IL-1α signaling through IRAK1 and IRAK4, p38-MAPK, and NF-κB. Apigenin was particularly potent at suppressing the expression and secretion of CXCL10 (IP10), a newly identified SASP factor. Further, apigenin-mediated suppression of the SASP substantially reduced the aggressive phenotype of human breast cancer cells, as determined by cell proliferation, extracellular matrix invasion, and epithelial-mesenchymal transition. Our results support the idea that apigenin is a promising natural product for reducing the impact of senescent cells on age-related diseases such as cancer.

The oxygen-centered radicals scavenging activity of sulfasalazine and its metabolites. A direct protection of the bowel.

PubMed

Prónai, L; Yukinobu, I; Láng, I; Fehér, J

1992-01-01

Oxygen-centered radicals, such as superoxide (O2-) and hydroxyl radicals (.OH) generated by phagocytes have been suggested to be involved in the pathogenesis of chronic inflammations of the bowel, such as Crohn's disease and colitis ulcerosa. Recently, sulfasalazine (SASP) and its metabolites have been reported to exert their effects as a direct scavenger of oxygen-centered radicals in the bowel. To scavenge oxygen-centered radicals in vivo, however, SASP and its metabolites have to react with O2- and/or .OH in vitro very rapidly, furthermore they have to reach an appropriate (possible millimolar) concentration range at the site of inflammation. To test this possibility, we investigated the direct O2- and .OH scavenging activity of SASP and its metabolites using the specific electron paramagnetic resonance/spin trapping method, and we compared the 50% inhibition rates of SASP and its metabolites with their known concentrations in the bowel and in the human plasma. It was found that SASP and its metabolites, such as 5-amino-salicylic acid (5-ASA), and acetyl-5-amino-salicylic acid (AC-5-ASA), but not sulfapyridine (SP) and acetyl-sulfapyridine (Ac-SP) have a direct O2- and .OH scavenging activity in vitro systems. Among the compounds, SASP and 5-ASA can reach a concentration which is appropriate to scavenge oxygen-centered radicals in the bowel but not in the human plasma. It was concluded that the in vivo antiinflammatory effects of SASP and its metabolites are, at least partly, due to the direct oxygen-centered scavenging activity of these drugs.

Fast and robust reconstruction for fluorescence molecular tomography via a sparsity adaptive subspace pursuit method.

PubMed

Ye, Jinzuo; Chi, Chongwei; Xue, Zhenwen; Wu, Ping; An, Yu; Xu, Han; Zhang, Shuang; Tian, Jie

2014-02-01

Fluorescence molecular tomography (FMT), as a promising imaging modality, can three-dimensionally locate the specific tumor position in small animals. However, it remains challenging for effective and robust reconstruction of fluorescent probe distribution in animals. In this paper, we present a novel method based on sparsity adaptive subspace pursuit (SASP) for FMT reconstruction. Some innovative strategies including subspace projection, the bottom-up sparsity adaptive approach, and backtracking technique are associated with the SASP method, which guarantees the accuracy, efficiency, and robustness for FMT reconstruction. Three numerical experiments based on a mouse-mimicking heterogeneous phantom have been performed to validate the feasibility of the SASP method. The results show that the proposed SASP method can achieve satisfactory source localization with a bias less than 1mm; the efficiency of the method is much faster than mainstream reconstruction methods; and this approach is robust even under quite ill-posed condition. Furthermore, we have applied this method to an in vivo mouse model, and the results demonstrate the feasibility of the practical FMT application with the SASP method.

A miR-335/COX-2/PTEN axis regulates the secretory phenotype of senescent cancer-associated fibroblasts

PubMed Central

Kabir, Tasnuva D.; Leigh, Ross J.; Tasena, Hataitip; Mellone, Massimiliano; Coletta, Ricardo D.; Parkinson, Eric K.; Prime, Stephen S.; Thomas, Gareth J.; Paterson, Ian C.; Zhou, Donghui; McCall, John; Speight, Paul M.; Lambert, Daniel W.

2016-01-01

Senescent cancer-associated fibroblasts (CAF) develop a senescence-associated secretory phenotype (SASP) that is believed to contribute to cancer progression. The mechanisms underlying SASP development are, however, poorly understood. Here we examined the functional role of microRNA in the development of the SASP in normal fibroblasts and CAF. We identified a microRNA, miR-335, up-regulated in the senescent normal fibroblasts and CAF and able to modulate the secretion of SASP factors and induce cancer cell motility in co-cultures, at least in part by suppressing the expression of phosphatase and tensin homologue (PTEN). Additionally, elevated levels of cyclo-oxygenase 2 (PTGS2; COX-2) and prostaglandin E2 (PGE2) secretion were observed in senescent fibroblasts, and inhibition of COX-2 by celecoxib reduced the expression of miR-335, restored PTEN expression and decreased the pro-tumourigenic effects of the SASP. Collectively these data demonstrate the existence of a novel miRNA/PTEN-regulated pathway modulating the inflammasome in senescent fibroblasts. PMID:27385366

Possible role of ginsenoside Rb1 in skin wound healing via regulating senescent skin dermal fibroblast.

PubMed

Hou, Jingang; Kim, Sunchang

2018-05-05

Cellular senescence suppresses cancer by inducing irreversible cell growth arrest. Nevertheless, senescent cells is proposed as causal link with aging and aging-related pathologies. The physiological beneficial functions of senescent cells are still of paucity. Here we show that senescent human dermal fibroblast accelerates keratinocytes scratch wound healing and stimulates differentiation of fibroblast. Using oxidative stress (100 μM H 2 O 2 exposure for 1 h) induction, we successfully triggered fibroblast senescence and developed senescence associated secretory phenotype (SASP). The induction of SASP was regulated by p38MAPK/MSK2/NF-κB pathway. Interestingly, inhibition of p38MAPK activation only partially suppressed SASP. However, SASP was significantly inhibited by SB747651A, a specific MSK inhibitor. Additionally, we demonstrate that SASP stimulates migration of keratinocytes and myofibroblast transition of fibroblast, through fold-increased secretion of growth factors, platelet-derived growth factor AA (PDGF-AA) and AB (PDGF-AB), transforming growth factor beta 1 (TGF-β1) and beta 2 (TGF-β2), vascular endothelial growth factor A (VEGF-A) and D (VEGF-D), vascular endothelial growth factor receptor 2 (VEGFR2) and 3 (VEGFR3). Importantly, we also confirmed ginsenoside Rb1 promoted SASP-mediated healing process via p38MAPK/MSK2/NF-κB pathway. The results pointed to senescent fibroblast as a potential mechanism of wound healing control in human skin. Further, it provided a candidate targeted for wound therapy. Copyright © 2018 Elsevier Inc. All rights reserved.

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coppé, Jean-Philippe; Patil, Christopher; Rodier, Francis

2008-10-24

Cellular senescence suppresses cancer by arresting cell proliferation, essentially permanently, in response to oncogenic stimuli, including genotoxic stress. We modified the use of antibody arrays to provide a quantitative assessment of factors secreted by senescent cells. We show that human cells induced to senesce by genotoxic stress secrete myriad factors associated with inflammation and malignancy. This senescence-associated secretory phenotype (SASP) developed slowly over several days and only after DNA damage of sufficient magnitude to induce senescence. Remarkably similar SASPs developed in normal fibroblasts, normal epithelial cells, and epithelial tumor cells after genotoxic stress in culture, and in epithelial tumor cellsmore » in vivo after treatment of prostate cancer patients with DNA-damaging chemotherapy. In cultured premalignant epithelial cells, SASPs induced an epithelial-mesenchyme transition and invasiveness, hallmarks of malignancy, by a paracrine mechanism that depended largely on the SASP factors interleukin (IL)-6 and IL-8. Strikingly, two manipulations markedly amplified, and accelerated development of, the SASPs: oncogenic RAS expression, which causes genotoxic stress and senescence in normal cells, and functional loss of the p53 tumor suppressor protein. Both loss of p53 and gain of oncogenic RAS also exacerbated the promalignant paracrine activities of the SASPs. Our findings define a central feature of genotoxic stress-induced senescence. Moreover, they suggest a cell-nonautonomous mechanism by which p53 can restrain, and oncogenic RAS can promote, the development of age-related cancer by altering the tissue microenvironment.« less

[Induction of robust senescence-associated secretory phenotype in mouse NIH-3T3 cells by mitomycin C].

PubMed

Huang, Wei-Xing; Guo, Xiao-Xuan; Peng, Zhong-Zhi; Weng, Chun-Liang; Huang, Chun-Yan; Shi, Ben-Yan; Yang, Jie; Liao, Xiao-Xin; Li, Xiao-Yi; Zheng, Hui-Ling; Liu, Xin-Guang; Sun, Xue-Rong

2017-02-25

Senescence-associated secretory phenotype (SASP) is often a concomitant result of cell senescence, embodied by the enhanced function of secretion. The SASP factors secreted by senescent cells include cytokines, proteases and chemokines, etc, which can exert great influence on local as well as systemic environment and participate in the process of cell senescence, immunoregulation, angiogenesis, cell proliferation and tumor invasion, etc. Relative to the abundance of SASP models in human cells, the in vitro SASP model derived from mouse cells is scarce at present. Therefore, the study aimed to establish a mouse SASP model to facilitate the research in the field. With this objective, we treated the INK4a-deficient mouse NIH-3T3 cells and the wildtype mouse embryonic fibroblasts (MEF) respectively with mitomycin C (MMC), an anticarcinoma drug which could induce DNA damage. The occurring of cell senescence was evaluated by cell morphology, β-gal staining, integration ratio of EdU and Western blot. Quantitative RT-PCR and ELISA were used to detect the expression and secretion of SASP factors, respectively. The results showed that, 8 days after the treatment of NIH-3T3 cells with MMC (1 μg/mL) for 12 h or 24 h, the cells became enlarged and the ratios of β-gal-positive (blue-stained) cells significantly increased, up to 77.4% and 90.4%, respectively. Meanwhile, the expression of P21 protein increased and the integration ratios of EdU significantly decreased (P < 0.01). Quantitative RT-PCR detection showed that the mRNA levels of several SASP genes, including IL-6, TNF-α, IL-1α and IL-1β increased evidently. ELISA detection further observed an enhanced secretion of IL-6 (P < 0.01). On the contrary, although wildtype MEF could also be induced into senescence by MMC treatment for 12 h or 24 h, embodied by the enlarged cell volume, increased ratios of β-gal-positive cells (up to 71.7% and 80.2%, respectively) and enhanced expression of P21 protein, the secretion of IL-6 displayed no significant change. Our study indicated that, although MMC could induce senescence in both mouse NIH-3T3 cells and wildtype MEF, only senescent NIH-3T3 cells displayed the canonical SASP phenomena. Current study suggested that senescent NIH-3T3 cells might be an appropriate in vitro SASP model of mouse cells.

Effects of modified Sanhuang decoction () enema on serum tumor necrosis factor-α and colonic mucosa interleukin-1β, interleukin-6 levels in ulcerative colitis rats.

PubMed

Wang, Shuai; Zhou, Tao; Zhai, Jun-Peng; Wang, Li-Hua; Chen, Jing

2014-11-01

To investigate the effects of Modified Sanhuang Decoction (, MSD) enema on the serum tumor necrosis factor alpha (TNF-α) and colonic mucosa interleukin-1β (IL-1β), interleukin-6 (IL-6) levels in experimental ulcerative colitis (UC) rats. Forty-five male Wistar rats were randomly divided into 4 groups: normal group (n=12), model group (n=11), salazosulfapyridine (SASP) group (n=11) and MSD group (n=11). The UC model was induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS)/ethanol solution. Rats in the normal group and model group were clystered with 0.9% normal saline, while in the SASP group and MSD group were clystered with SASP and MSD enema, respectively. After drug administration (10 mL/kg body weight, for 7 days), colonic gross changes and colonic mucosa histology were observed, serum TNF-α and colonic mucosa IL-1β, IL-6 levels were tested by enzyme linked immunosorbent assay and radioimmunoassay, respectively. As compared with the normal group, the experimental UC rats, the colonic mucosal damage index scores (CMDIs), histopathological scores (HS) and the serum TNF-α and colonic mucosa IL-1β, IL-6 levels significantly increased (P<0.05 or P<0.01). In the MSD and SASP groups, the ulcer area significantly reduced, and edema disappeared. The CMDIs, HS, the serum TNF-α and colonic mucosa IL-1β, IL-6 levels in the MSD and SASP groups significantly decreased (P<0.05 or P<0.01) compared with the model group. The CMDIs in the MSD group were lower than that in the SASP group (P<0.05), but there were no significant differences in HS, serum TNF-α or colonic mucosa IL-1β, IL-6 levels between the MSD and SASP groups. MSD enema can improve colonic mucosa impairment and decrease serum TNF-α and colonic mucosa IL-1β, IL-6 levels in experimental UC.

Small acid soluble proteins for rapid spore identification.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Branda, Steven S.; Lane, Todd W.; VanderNoot, Victoria A.

2006-12-01

This one year LDRD addressed the problem of rapid characterization of bacterial spores such as those from the genus Bacillus, the group that contains pathogenic spores such as B. anthracis. In this effort we addressed the feasibility of using a proteomics based approach to spore characterization using a subset of conserved spore proteins known as the small acid soluble proteins or SASPs. We proposed developing techniques that built on our previous expertise in microseparations to rapidly characterize or identify spores. An alternative SASP extraction method was developed that was amenable to both the subsequent fluorescent labeling required for laser-induced fluorescencemore » detection and the low ionic strength requirements for isoelectric focusing. For the microseparations, both capillary isoelectric focusing and chip gel electrophoresis were employed. A variety of methods were evaluated to improve the molecular weight resolution for the SASPs, which are in a molecular weight range that is not well resolved by the current methods. Isoelectric focusing was optimized and employed to resolve the SASPs using UV absorbance detection. Proteomic signatures of native wild type Bacillus spores and clones genetically engineered to produce altered SASP patterns were assessed by slab gel electrophoresis, capillary isoelectric focusing with absorbance detection as well as microchip based gel electrophoresis employing sensitive laser-induced fluorescence detection.« less

Enhanced Molecular Aging in Late-Life Depression: the Senescent-Associated Secretory Phenotype.

PubMed

Diniz, Breno Satler; Reynolds, Charles F; Sibille, Etienne; Lin, Chien-Wei; Tseng, George; Lotrich, Francis; Aizenstein, Howard J; Butters, Meryl A

2017-01-01

This study aims to investigate whether a systemic molecular pattern associated with aging (senescent-associated secretory phenotype [SASP]) is elevated in adults with late-life depression (LLD), compared with never-depressed elderly comparison participants. Cross-sectional study. We included 111 older adults (80 with LLD and 31 comparison participants) in this study. A panel of 22 SASP-related proteins was extracted from a previous multiplex protein panel performed in these participants. We conducted a principal component analysis to create the SASP index based on individual weights of each of protein. Participants with LLD showed a significantly increased SASP index compared with comparison participants, after controlling for age, depressive symptoms, medical comorbidity (CIRS-G) scores, sex, and cognitive performance (F (1,98)  = 7.3, p = 0.008). Correlation analyses revealed that the SASP index was positively correlated with age (r = 0.2, p = 0.03) and CIRS score (r = 0.27, p = 0.005), and negatively correlated with information processing speed (r = -0.34, p = 0.001), executive function (r = -0.27, p = 0.004) and global cognitive performance (r = -0.28, p = 0.007). To the best of our knowledge, this is the first study to show that a set of proteins (i.e., SASP index) primarily associated with cellular aging is abnormally regulated and elevated in LLD. These results suggest that individuals with LLD display enhanced aging-related molecular patterns that are associated with higher medical comorbidity and worse cognitive function. Finally, we provide a set of proteins that can serve as potential therapeutic targets and biomarkers to monitor the effects of therapeutic or preventative interventions in LLD. Copyright © 2017 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.

Enhanced molecular aging in late-life depression: the Senescent Associated Secretory Phenotype

PubMed Central

Diniz, Breno Satler; Reynolds, Charles F.; Sibille, Etienne; Lin, Chien-Wei; Tseng, George; Lotrich, Francis; Aizenstein, Howard J.; Butters, Meryl A.

2016-01-01

Objective This study aims to investigate whether a systemic molecular pattern associated with aging (senescent-associated secretory phenotype – SASP) is elevated in adults with late-life depression (LLD), compared to never-depressed elderly comparison participants. Design Cross-sectional study. Participants We included 111 older adults (80 with LLD and 31 comparison participants) in this study. Measurement A panel of 22 SASP-related proteins was extracted from a previous multiplex protein panel performed in these participants. We conducted a principal component analysis to create the SASP index based on individual weights of each of protein. Results Participants with LLD showed a significantly increased SASP index compared to comparison participants, after controlling for age, depressive symptoms, medical comorbidity (CIRS-G) scores, gender, and cognitive performance (F(1,98)=7.3, p=0.008). Correlation analyses revealed that the SASP index was positively correlated with age (r=0.2, p = 0.03) and CIRS score (r=0.27, p=0.005), and negatively correlated with information processing speed (r=−0.34, p=0.001), executive function (r=−0.27, p=0.004) and global cognitive performance (r=−0.28, p=0.007). Conclusions To the best of our knowledge, this is the first study to show that a set of proteins (i.e., SASP index) primarily associated with cellular aging, is abnormally regulated and elevated in LLD. These results suggest that individuals with LLD display enhanced aging-related molecular patterns that are associated with higher medical comorbidity and worse cognitive function. Finally, we provide a set of proteins that can serve as potential therapeutic targets and biomarkers to monitor the effects of therapeutic or preventative interventions in LLD. PMID:27856124

Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma.

PubMed

Mario Gonzalez-Meljem, Jose; Haston, Scott; Carreno, Gabriela; Apps, John R; Pozzi, Sara; Stache, Christina; Kaushal, Grace; Virasami, Alex; Panousopoulos, Leonidas; Neda Mousavy-Gharavy, Seyedeh; Guerrero, Ana; Rashid, Mamunur; Jani, Nital; Goding, Colin R; Jacques, Thomas S; Adams, David J; Gil, Jesus; Andoniadou, Cynthia L; Martinez-Barbera, Juan Pedro

2017-11-28

Senescent cells may promote tumour progression through the activation of a senescence-associated secretory phenotype (SASP), whether these cells are capable of initiating tumourigenesis in vivo is not known. Expression of oncogenic β-catenin in Sox2+ young adult pituitary stem cells leads to formation of clusters of stem cells and induction of tumours resembling human adamantinomatous craniopharyngioma (ACP), derived from Sox2- cells in a paracrine manner. Here, we uncover the mechanisms underlying this paracrine tumourigenesis. We show that expression of oncogenic β-catenin in Hesx1+ embryonic precursors also results in stem cell clusters and paracrine tumours. We reveal that human and mouse clusters are analogous and share a common signature of senescence and SASP. Finally, we show that mice with reduced senescence and SASP responses exhibit decreased tumour-inducing potential. Together, we provide evidence that senescence and a stem cell-associated SASP drive cell transformation and tumour initiation in vivo in an age-dependent fashion.

41 CFR 102-37.190 - What records must a SASP maintain on authorized screeners?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY State Agency for Surplus Property (SASP) Screening and... records in the donee's eligibility file and review for currency each time a periodic review of the donee's...

41 CFR 102-37.190 - What records must a SASP maintain on authorized screeners?

Code of Federal Regulations, 2011 CFR

2011-01-01

... Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY State Agency for Surplus Property (SASP) Screening and... records in the donee's eligibility file and review for currency each time a periodic review of the donee's...

41 CFR 102-37.185 - How does a SASP obtain screening authorization for itself or its donees?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false How does a SASP obtain... Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT... Form 92 (with the signature and an affixed passport-style photograph of the screener applicant) and a...

Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype.

PubMed

Wiley, Christopher D; Schaum, Nicholas; Alimirah, Fatouma; Lopez-Dominguez, Jose Alberto; Orjalo, Arturo V; Scott, Gary; Desprez, Pierre-Yves; Benz, Christopher; Davalos, Albert R; Campisi, Judith

2018-02-05

Processes that have been linked to aging and cancer include an inflammatory milieu driven by senescent cells. Senescent cells lose the ability to divide, essentially irreversibly, and secrete numerous proteases, cytokines and growth factors, termed the senescence-associated secretory phenotype (SASP). Senescent cells that lack p53 tumor suppressor function show an exaggerated SASP, suggesting the SASP is negatively controlled by p53. Here, we show that increased p53 activity caused by small molecule inhibitors of MDM2, which promotes p53 degradation, reduces inflammatory cytokine production by senescent cells. Upon treatment with the MDM2 inhibitors nutlin-3a or MI-63, human cells acquired a senescence-like growth arrest, but the arrest was reversible. Importantly, the inhibitors reduced expression of the signature SASP factors IL-6 and IL-1α by cells made senescent by genotoxic stimuli, and suppressed the ability of senescent fibroblasts to stimulate breast cancer cell aggressiveness. Our findings suggest that MDM2 inhibitors could reduce cancer progression in part by reducing the pro-inflammatory environment created by senescent cells.

Senescence-Associated MCP-1 Secretion Is Dependent on a Decline in BMI1 in Human Mesenchymal Stromal Cells

PubMed Central

Jin, Hye Jin; Lee, Hyang Ju; Heo, Jinbeom; Lim, Jisun; Kim, Miyeon; Kim, Min Kyung; Nam, Hae Yun; Hong, Gyong Hwa; Cho, You Sook; Choi, Soo Jin; Kim, In-Gyu

2016-01-01

Abstract Aims: Cellular senescence and its secretory phenotype (senescence-associated secretory phenotype [SASP]) develop after long-term expansion of mesenchymal stromal cells (MSCs). Further investigation of this phenotype is required to improve the therapeutic efficacy of MSC-based cell therapies. In this study, we show that positive feedback between SASP and inherent senescence processes plays a crucial role in the senescence of umbilical cord blood-derived MSCs (UCB-MSCs). Results: We found that monocyte chemoattractant protein-1 (MCP-1) was secreted as a dominant component of the SASP during expansion of UCB-MSCs and reinforced senescence via its cognate receptor chemokine (c-c motif) receptor 2 (CCR2) by activating the ROS-p38-MAPK-p53/p21 signaling cascade in both an autocrine and paracrine manner. The activated p53 in turn increased MCP-1 secretion, completing a feed-forward loop that triggered the senescence program in UCB-MSCs. Accordingly, knockdown of CCR2 in UCB-MSCs significantly improved their therapeutic ability to alleviate airway inflammation in an experimental allergic asthma model. Moreover, BMI1, a polycomb protein, repressed the expression of MCP-1 by binding to its regulatory elements. The reduction in BMI1 levels during UCB-MSC senescence altered the epigenetic status of MCP-1, including the loss of H2AK119Ub, and resulted in derepression of MCP-1. Innovation: Our results provide the first evidence supporting the existence of the SASP as a causative contributor to UCB-MSC senescence and reveal a so far unappreciated link between epigenetic regulation and SASP for maintaining a stable senescent phenotype. Conclusion: Senescence of UCB-MSCs is orchestrated by MCP-1, which is secreted as a major component of the SASP and is epigenetically regulated by BMI1. Antioxid. Redox Signal. 24, 471–485. PMID:26573462

41 CFR 102-37.200 - What certifications must a SASP make when requesting surplus property for donation?

Code of Federal Regulations, 2010 CFR

2010-07-01

... a SASP make when requesting surplus property for donation? 102-37.200 Section 102-37.200 Public... MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY State Agency for Surplus... requesting surplus property for donation? When requesting or applying for property, you must certify that: (a...

41 CFR 102-37.200 - What certifications must a SASP make when requesting surplus property for donation?

Code of Federal Regulations, 2013 CFR

2013-07-01

... a SASP make when requesting surplus property for donation? 102-37.200 Section 102-37.200 Public... MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY State Agency for Surplus... requesting surplus property for donation? When requesting or applying for property, you must certify that: (a...

41 CFR 102-37.200 - What certifications must a SASP make when requesting surplus property for donation?

Code of Federal Regulations, 2011 CFR

2011-01-01

... a SASP make when requesting surplus property for donation? 102-37.200 Section 102-37.200 Public... MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY State Agency for Surplus... requesting surplus property for donation? When requesting or applying for property, you must certify that: (a...

41 CFR 102-37.200 - What certifications must a SASP make when requesting surplus property for donation?

Code of Federal Regulations, 2012 CFR

2012-01-01

... a SASP make when requesting surplus property for donation? 102-37.200 Section 102-37.200 Public... MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY State Agency for Surplus... requesting surplus property for donation? When requesting or applying for property, you must certify that: (a...

41 CFR 102-37.200 - What certifications must a SASP make when requesting surplus property for donation?

Code of Federal Regulations, 2014 CFR

2014-01-01

... a SASP make when requesting surplus property for donation? 102-37.200 Section 102-37.200 Public... MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY State Agency for Surplus... requesting surplus property for donation? When requesting or applying for property, you must certify that: (a...

41 CFR 102-41.230 - May SASPs pick up or store donated drug paraphernalia in their distribution centers?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false May SASPs pick up or store donated drug paraphernalia in their distribution centers? 102-41.230 Section 102-41.230 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL...

41 CFR 102-37.275 - May a SASP accept personal checks and non-official payment methods in payment of service charges?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false May a SASP accept....275 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY State Agency for...

Targeting the SASP to combat ageing: Mitochondria as possible intracellular allies?

PubMed

Birch, Jodie; Passos, João F

2017-05-01

Anti-senescence therapies, such as drugs that specifically kill senescent cells, to stave off ageing are currently under investigation. While these interventions show promise, their potential pitfalls are discussed herein. We have shown that the mitochondria are essential for development of senescence and many of the associated phenotypes, including the often detrimental senescence-associated secretory phenotype (SASP). Here, we disentangle many ways in which the mitochondria may influence senescence and development of the SASP and focus on possible pathways that could be exploited for future generation of anti-senescence therapies with a clear aim; to specifically eliminate the problematic features of senescent cells, while maintaining their beneficial characteristics. © 2017 The Authors. BioEssays Published by WILEY Periodicals, Inc.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Forte, A M; Quere, S; Moucha, R

Recent progress in seismic tomography provides the first complete 3-D images of the combined thermal and chemical anomalies that characterise the unique deep mantle structure below the African continent. With these latest tomography results we predict flow patterns under Africa that reveal a large-scale, active hot upwelling, or superplume, below the western margin of Africa under the Cape Verde Islands. The scale and dynamical intensity of this West African superplume (WASP) is comparable to that of the south African superplume (SASP) that has long been assumed to dominate the flow dynamics under Africa. On the basis of this new tomographymore » model, we find the dynamics of the SASP is strongly controlled by chemical contributions to deep mantle buoyancy that significantly compensate its thermal buoyancy. In contrast, the WASP appears to be entirely dominated by thermal buoyancy. New calculations of mantle convection incorporating these two superplumes reveal that the plate-driving forces due to the flow generated by the WASP is as strong as that due to the SASP. We find that the chemical buoyancy of the SASP exerts a strong stabilising control on the pattern and amplitude of shallow mantle flow in the asthenosphere below the southern half of the African plate. The asthenospheric flow predictions provide the first high resolution maps of focussed upwellings that lie below the major centres of Late Cenozoic volcanism, including the Kenya domes and Hoggar massif that lies above a remnant plume head in the upper mantle. Inferences of sublithospheric deformation from seismic anisotropy data are shown to be sensitive to the contributions of chemical buoyancy in the SASP.« less

41 CFR 102-37.465 - May a SASP modify or release any of the terms and conditions of donation?

Code of Federal Regulations, 2010 CFR

2010-07-01

... release any of the terms and conditions of donation? 102-37.465 Section 102-37.465 Public Contracts and... REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Donations to Public Agencies, Service... SASP modify or release any of the terms and conditions of donation? You may alter or grant releases...

41 CFR 102-37.465 - May a SASP modify or release any of the terms and conditions of donation?

Code of Federal Regulations, 2013 CFR

2013-07-01

... release any of the terms and conditions of donation? 102-37.465 Section 102-37.465 Public Contracts and... REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Donations to Public Agencies, Service... SASP modify or release any of the terms and conditions of donation? You may alter or grant releases...

41 CFR 102-37.465 - May a SASP modify or release any of the terms and conditions of donation?

Code of Federal Regulations, 2011 CFR

2011-01-01

... release any of the terms and conditions of donation? 102-37.465 Section 102-37.465 Public Contracts and... REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Donations to Public Agencies, Service... SASP modify or release any of the terms and conditions of donation? You may alter or grant releases...

41 CFR 102-37.465 - May a SASP modify or release any of the terms and conditions of donation?

Code of Federal Regulations, 2012 CFR

2012-01-01

... release any of the terms and conditions of donation? 102-37.465 Section 102-37.465 Public Contracts and... REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Donations to Public Agencies, Service... SASP modify or release any of the terms and conditions of donation? You may alter or grant releases...

41 CFR 102-37.465 - May a SASP modify or release any of the terms and conditions of donation?

Code of Federal Regulations, 2014 CFR

2014-01-01

... release any of the terms and conditions of donation? 102-37.465 Section 102-37.465 Public Contracts and... REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Donations to Public Agencies, Service... SASP modify or release any of the terms and conditions of donation? You may alter or grant releases...

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

PubMed Central

Xu, Ming; Tchkonia, Tamara; Ding, Husheng; Ogrodnik, Mikolaj; Lubbers, Ellen R.; Pirtskhalava, Tamar; White, Thomas A.; Johnson, Kurt O.; Stout, Michael B.; Mezera, Vojtech; Giorgadze, Nino; Jensen, Michael D.; LeBrasseur, Nathan K.; Kirkland, James L.

2015-01-01

Chronic, low grade, sterile inflammation frequently accompanies aging and age-related diseases. Cellular senescence is associated with the production of proinflammatory chemokines, cytokines, and extracellular matrix (ECM) remodeling proteases, which comprise the senescence-associated secretory phenotype (SASP). We found a higher burden of senescent cells in adipose tissue with aging. Senescent human primary preadipocytes as well as human umbilical vein endothelial cells (HUVECs) developed a SASP that could be suppressed by targeting the JAK pathway using RNAi or JAK inhibitors. Conditioned medium (CM) from senescent human preadipocytes induced macrophage migration in vitro and inflammation in healthy adipose tissue and preadipocytes. When the senescent cells from which CM was derived had been treated with JAK inhibitors, the resulting CM was much less proinflammatory. The administration of JAK inhibitor to aged mice for 10 wk alleviated both adipose tissue and systemic inflammation and enhanced physical function. Our findings are consistent with a possible contribution of senescent cells and the SASP to age-related inflammation and frailty. We speculate that SASP inhibition by JAK inhibitors may contribute to alleviating frailty. Targeting the JAK pathway holds promise for treating age-related dysfunction. PMID:26578790

Mitochondrial peptides modulate mitochondrial function during cellular senescence.

PubMed

Kim, Su-Jeong; Mehta, Hemal H; Wan, Junxiang; Kuehnemann, Chisaka; Chen, Jingcheng; Hu, Ji-Fan; Hoffman, Andrew R; Cohen, Pinchas

2018-06-10

Cellular senescence is a complex cell fate response that is thought to underlie several age-related pathologies. Despite a loss of proliferative potential, senescent cells are metabolically active and produce energy-consuming effectors, including senescence-associated secretory phenotypes (SASPs). Mitochondria play crucial roles in energy production and cellular signaling, but the key features of mitochondrial physiology and particularly of mitochondria-derived peptides (MDPs), remain underexplored in senescence responses. Here, we used primary human fibroblasts made senescent by replicative exhaustion, doxorubicin or hydrogen peroxide treatment, and examined the number of mitochondria and the levels of mitochondrial respiration, mitochondrial DNA methylation and the mitochondria-encoded peptides humanin, MOTS-c, SHLP2 and SHLP6. Senescent cells showed increased numbers of mitochondria and higher levels of mitochondrial respiration, variable changes in mitochondrial DNA methylation, and elevated levels of humanin and MOTS-c. Humanin and MOTS-c administration modestly increased mitochondrial respiration and selected components of the SASP in doxorubicin-induced senescent cells partially via JAK pathway. Targeting metabolism in senescence cells is an important strategy to reduce SASP production for eliminating the deleterious effects of senescence. These results provide insight into the role of MDPs in mitochondrial energetics and the production of SASP components by senescent cells.

Combination therapy in early rheumatoid arthritis: a randomised, controlled, double blind 52 week clinical trial of sulphasalazine and methotrexate compared with the single components

PubMed Central

Dougados, M.; Combe, B.; Cantagrel, A.; Goupille, P.; Olive, P.; Schattenkirchner, M.; Meusser, S; Paimela, L; Rau, R.; Zeidler, H.; Leirisalo-Repo, M.; Peldan, K.

1999-01-01

OBJECTIVES—To investigate the potential clinical benefit of a combination therapy.
METHODS—205 patients fulfilling the ACR criteria for rheumatoid arthritis (RA), not treated with disease modifying anti-rheumatoid drugs previously, with an early (⩽1 year duration), active (Disease Activity Score (DAS) > 3.0), rheumatoid factor and/or HLA DR 1/4 positive disease were randomised between sulphasalazine (SASP) 2000 (maximum 3000) mg daily (n = 68), or methotrexate (MTX) 7.5 (maximum 15) mg weekly (n = 69) or the combination (SASP + MTX) of both (n = 68).
RESULTS—The mean changes in the DAS during the one year follow up of the study was −1.15, −0.87, −1.26 in the SASP, MTX, and SASP + MTX group respectively (p = 0.019). However, there was no statistically significant difference in terms of either EULAR good responders 34%, 38%, 38% or ACR criteria responders 59%, 59%, 65% in the SASP, MTX, and SASP + MTX group respectively. Radiological progression evaluated by the modified Sharp score was very modest in the three groups: mean changes in erosion score: +2.4, +2.4, +1.9, in narrowing score: +2.3, +2.1, +1.6 and in total damage score: +4.6, +4.5, +3.5, in the SASP, MTX, and SASP + MTX groups respectively. Adverse events occurred more frequently in the SASP + MTX group 91% versus 75% in the SASP and MTX group (p = 0.025). Nausea was the most frequent side effect: 32%, 23%, 49% in the SASP, MTX, and SASP + MTX groups respectively (p = 0.007).
CONCLUSION—This study suggests that an early initiation therapy of disease modifying drug seems to be of benefit. However, this study was unable to demonstrate a clinically relevant superiority of the combination therapy although several outcomes were in favour of this observation. The tolerability of the three treatment modalities seems acceptable.

 Keywords: rheumatoid arthritis; combination therapy; sulphasalazine; methotrexate PMID:10364900

Redox-Dependent Calcium-Mediated Signaling Networks that Control the Senescence-Associated Secretory Phenotype

NASA Astrophysics Data System (ADS)

Chandrasekaran, Akshaya

Cellular senescence has evolved as a protective mechanism to arrest growth of cells with oncogenic potential. While senescent cells have lost the ability to divide, they remain metabolically active and adapt a deleterious senescence associated secretory phenotype (SASP) central to the progression of several age-associated disease pathologies. The SASP is mechanistically regulated by the pro-inflammatory cytokine interleukin-1 alpha (IL-1alpha) whose expression and activity is responsive to the senescence associated (SA) oxidant production and the accompanying disruption of calcium (Ca2+) homeostasis. Using primary IMR-90 human fetal lung fibroblasts as a model of replicative senescence, we explored the molecular underpinnings driving Ca2+ dysregulation in senescent cells. We establish that the redox-responsive Transient Receptor Potential TRPC6 channel is compromised due to desensitization owing to SA increases in steady state hydrogen peroxide (H2O2) production. SA dysregulation of Ca2+ is also accompanied by loss of response to H2O2-induced Ca2+ influx that can be rescued with catalase pre-treatments. Senescent cells are also insensitive to Ca2+ entry induced by hyperforin, a specific activator of TRPC6, that can be restored by catalase pre-treatments, further suggesting redox regulation of TRPC6 in senescence. Inhibition of TRPC6 channel activity restores the ability of senescent cells to respond to peroxide-induced Ca2+ in addition to suppressing SASP gene expression. Furthermore, mammalian target of rapamycin (mTOR) signaling regulates SASP by means of modulating TRPC6 channel expression. Together, our findings provide compelling evidence that redox and mTOR-mediated regulation of TRPC6 channel modulate SASP gene expression. Further, the gain-of-function mutation of TRPC6 has pathological implications in several chronic pathologies and renders it a viable target in age-associated diseases.

Resistance of Bacillus subtilis Spore DNA to Lethal Ionizing Radiation Damage Relies Primarily on Spore Core Components and DNA Repair, with Minor Effects of Oxygen Radical Detoxification

PubMed Central

Raguse, Marina; Reitz, Günther; Okayasu, Ryuichi; Li, Zuofeng; Klein, Stuart; Setlow, Peter; Nicholson, Wayne L.

2014-01-01

The roles of various core components, including α/β/γ-type small acid-soluble spore proteins (SASP), dipicolinic acid (DPA), core water content, and DNA repair by apurinic/apyrimidinic (AP) endonucleases or nonhomologous end joining (NHEJ), in Bacillus subtilis spore resistance to different types of ionizing radiation including X rays, protons, and high-energy charged iron ions have been studied. Spores deficient in DNA repair by NHEJ or AP endonucleases, the oxidative stress response, or protection by major α/β-type SASP, DPA, and decreased core water content were significantly more sensitive to ionizing radiation than wild-type spores, with highest sensitivity to high-energy-charged iron ions. DNA repair via NHEJ and AP endonucleases appears to be the most important mechanism for spore resistance to ionizing radiation, whereas oxygen radical detoxification via the MrgA-mediated oxidative stress response or KatX catalase activity plays only a very minor role. Synergistic radioprotective effects of α/β-type but not γ-type SASP were also identified, indicating that α/β-type SASP's binding to spore DNA is important in preventing DNA damage due to reactive oxygen species generated by ionizing radiation. PMID:24123749

Determination of the pK values of 5-aminosalicylic acid and N-acetylaminosalicylic acid and comparison of the pH dependent lipid-water partition coefficients of sulphasalazine and its metabolites.

PubMed

Allgayer, H; Sonnenbichler, J; Kruis, W; Paumgartner, G

1985-01-01

Sulphasalazine (SASP), used in the treatment of inflammatory bowel disease, is split into sulphapyridine (SP) and 5-aminosalicylic acid (5-ASA) in the colon. Lower plasma levels of SASP and 5-ASA as compared to those of SP may be due to different absorption rates from the colon because of different pK values and pH dependent lipid-water partition coefficients. In this study we determined the pK values of 5-ASA and its major metabolite, N-acetyl amino-salicylic acid (AcASA), by 13C-NMR spectroscopy and compared the pH dependent apparent benzene-water partition coefficients (Papp) of SASP, SP and 5-ASA with respect to their different plasma levels. The COOH group of 5-ASA had a pK value of 3.0, the -NH3+ group had 6.0, the -OH group 13.9; the -COOH group of AcASA had 2.7 and the -OH group 12.9; The Papp of SASP (0.042 +/- 0.004) and 5-ASA (0.059 +/- 0.01) were significantly lower than that of SP (0.092 +/- 0.03) (at pH 5.5).

41 CFR 102-37.250 - What actions must a SASP take when it learns of damage to or loss of surplus property in its...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What actions must a SASP take when it learns of damage to or loss of surplus property in its custody? 102-37.250 Section 102-37... learns of damage to or loss of surplus property in its custody? If you learn that surplus property in...

41 CFR 102-37.250 - What actions must a SASP take when it learns of damage to or loss of surplus property in its...

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What actions must a SASP take when it learns of damage to or loss of surplus property in its custody? 102-37.250 Section 102-37... learns of damage to or loss of surplus property in its custody? If you learn that surplus property in...

Excavating the surface-associated and secretory proteome of Mycobacterium leprae for identifying vaccines and diagnostic markers relevant immunodominant epitopes.

PubMed

Rana, Aarti; Thakur, Shweta; Bhardwaj, Nupur; Kumar, Devender; Akhter, Yusuf

2016-12-01

For centuries, Mycobacterium leprae, etiological agent of leprosy, has been afflicting mankind regardless of extensive use of live-attenuated vaccines and antibiotics. Surface-associated and secretory proteins (SASPs) are attractive targets against bacteria. We have integrated biological knowledge with computational approaches and present a proteome-wide identification of SASPs. We also performed computational assignment of immunodominant epitopes as coordinates of prospective antigenic candidates in most important class of SASPs, the outer membrane proteins (OMPs). Exploiting the known protein sequence and structural characteristics shared by the SASPs from bacteria, 17 lipoproteins, 11 secretory and 19 novel OMPs (including 4 essential proteins) were identified in M. leprae As OMPs represent the most exposed antigens on the cell surface, their immunoinformatics analysis showed that the identified 19 OMPs harbor T-cell MHC class I epitopes and class II epitopes against HLA-DR alleles (54), while 15 OMPs present potential T-cell class II epitopes against HLA-DQ alleles (6) and 7 OMPs possess T-cell class II epitopes against HLA-DP alleles (5) of humans. Additionally, 11 M. leprae OMPs were found to have B-cell epitopes and these may be considered as prime candidates for the development of new immunotherapeutics against M. leprae. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Resveratrol reduces senescence-associated secretory phenotype by SIRT1/NF-κB pathway in gut of the annual fish Nothobranchius guentheri.

PubMed

Liu, Shan; Zheng, Zhaodi; Ji, Shuhua; Liu, Tingting; Hou, Yanhan; Li, Shasha; Li, Guorong

2018-06-13

Senescent cells display a senescence-associated secretory phenotype (SASP), which contributes to aging. Resveratrol, an activator of SIRT1, has anti-aging, anti-inflammatory, anti-oxidant, anti-free radical and other pharmacological effects. The genus of the annual fish Nothobranchius has become an emerging animal model for studying aging. However, the underlying mechanism for resveratrol to delay aging by SASP regulation has not been elucidated in vertebrates. In this study, the annual fish N. guentheri were fed with resveratrol for long-term treatment. The results showed that resveratrol reversed intensive senescence-associated β-galactosidase activity with aging process, down-regulated levels of SASP-associated proinflammatory cytokines IL-8 and TNFα, and up-regulated expression of anti-inflammatory cytokine IL-10 in gut of the fish. Resveratrol increased SIRT1 expression, and inhibited NF-κB by decreasing RelA/p65, Ac-RelA/p65 and p-IκBα levels and by increasing the interaction between SIRT1 and RelA/p65. Moreover, resveratrol reversed the decline of intestinal epithelial cells (IECs) and intestinal stem cells (ISCs) caused by aging in gut of the fish. Together, our results implied that resveratrol inhibited SASP through SIRT1/NF-κB signaling pathway and delayed aging of the annual fish N. guentheri. Copyright © 2018. Published by Elsevier Ltd.

Multifactorial Resistance of Bacillus subtilis Spores to High-Energy Proton Radiation: Role of Spore Structural Components and the Homologous Recombination and Non-Homologous End Joining DNA Repair Pathways

PubMed Central

Reitz, Günther; Li, Zuofeng; Klein, Stuart; Nicholson, Wayne L.

2012-01-01

Abstract The space environment contains high-energy charged particles (e.g., protons, neutrons, electrons, α-particles, heavy ions) emitted by the Sun and galactic sources or trapped in the radiation belts. Protons constitute the majority (87%) of high-energy charged particles. Spores of Bacillus species are one of the model systems used for astro- and radiobiological studies. In this study, spores of different Bacillus subtilis strains were used to study the effects of high energetic proton irradiation on spore survival. Spores of the wild-type B. subtilis strain [mutants deficient in the homologous recombination (HR) and non-homologous end joining (NHEJ) DNA repair pathways and mutants deficient in various spore structural components such as dipicolinic acid (DPA), α/β-type small, acid-soluble spore protein (SASP) formation, spore coats, pigmentation, or spore core water content] were irradiated as air-dried multilayers on spacecraft-qualified aluminum coupons with 218 MeV protons [with a linear energy transfer (LET) of 0.4 keV/μm] to various final doses up to 2500 Gy. Spores deficient in NHEJ- and HR-mediated DNA repair were significantly more sensitive to proton radiation than wild-type spores, indicating that both HR and NHEJ DNA repair pathways are needed for spore survival. Spores lacking DPA, α/β-type SASP, or with increased core water content were also significantly more sensitive to proton radiation, whereas the resistance of spores lacking pigmentation or spore coats was essentially identical to that of the wild-type spores. Our results indicate that α/β-type SASP, core water content, and DPA play an important role in spore resistance to high-energy proton irradiation, suggesting their essential function as radioprotectants of the spore interior. Key Words: Bacillus—Spores—DNA repair—Protection—High-energy proton radiation. Astrobiology 12, 1069–1077. PMID:23088412

Oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis.

PubMed

Wang, Yongjun; Parker, Claire E; Feagan, Brian G; MacDonald, John K

2016-05-09

Oral 5-aminosalicylic (5-ASA) preparations were intended to avoid the adverse effects of sulfasalazine (SASP) while maintaining its therapeutic benefits. Previously, it was found that 5-ASA drugs were more effective than placebo but had a statistically significant therapeutic inferiority relative to SASP. This updated review includes more recent studies and evaluates the effectiveness, dose-responsiveness, and safety of 5-ASA preparations used for maintenance of remission in quiescent ulcerative colitis. The primary objectives were to assess the efficacy, dose-responsiveness and safety of oral 5-ASA compared to placebo, SASP, or 5-ASA comparators for maintenance of remission in quiescent ulcerative colitis. A secondary objective was to compare the efficacy and safety of once daily dosing of oral 5-ASA with conventional (two or three times daily) dosing regimens. A literature search for relevant studies (inception to 9 July 2015) was performed using MEDLINE, EMBASE and the Cochrane Library. Review articles and conference proceedings were also searched to identify additional studies. Studies were accepted for analysis if they were randomized controlled trials with a minimum treatment duration of six months. Studies of oral 5-ASA therapy for treatment of patients with quiescent ulcerative colitis compared with placebo, SASP or other 5-ASA formulations were considered for inclusion. Studies that compared once daily 5-ASA treatment with conventional dosing of 5-ASA and 5-ASA dose ranging studies were also considered for inclusion. The primary outcome was the failure to maintain clinical or endoscopic remission. Secondary outcomes included adherence, adverse events, withdrawals due to adverse events, and withdrawals or exclusions after entry. Trials were separated into five comparison groups: 5-ASA versus placebo, 5-ASA versus sulfasalazine, once daily dosing versus conventional dosing, 5-ASA versus comparator 5-ASA formulation, and 5-ASA dose-ranging. Placebo-controlled trials were subgrouped by dosage. Once daily versus conventional dosing studies were subgrouped by formulation. 5-ASA-controlled trials were subgrouped by common 5-ASA comparators (e.g. Asacol and Salofalk). Dose-ranging studies were subgrouped by 5-ASA formulation. We calculated the risk ratio (RR) and 95% confidence intervals (95% CI) for each outcome. Data were analyzed on an intention-to-treat basis. Forty-one studies (8928 patients) were included. The majority of included studies were rated as low risk of bias. Ten studies were rated at high risk of bias. Seven of these studies were single-blind and three studies were open-label. However, two open-label studies and four of the single-blind studies utilized investigator performed endoscopy as an endpoint, which may protect against bias. 5-ASA was significantly superior to placebo for maintenance of clinical or endoscopic remission. Forty-one per cent of 5-ASA patients relapsed compared to 58% of placebo patients (7 studies, 1298 patients; RR 0.69, 95% CI 0.62 to 0.77). There was a trend towards greater efficacy with higher doses of 5-ASA with a statistically significant benefit for the 1 to 1.9 g/day (RR 0.65; 95% CI 0.56 to 0.76) and the > 2 g/day subgroups (RR 0.73, 95% CI 0.60 to 0.89). SASP was significantly superior to 5-ASA for maintenance of remission. Forty-eight per cent of 5-ASA patients relapsed compared to 43% of SASP patients (12 studies, 1655 patients; RR 1.14, 95% CI 1.03 to 1.27). A GRADE analysis indicated that the overall quality of the evidence for the primary outcome for the placebo and SASP-controlled studies was high. No statistically significant differences in efficacy or adherence were found between once daily and conventionally dosed 5-ASA. Twenty-nine per cent of once daily patients relapsed over 12 months compared to 31% of conventionally dosed patients (8 studies, 3127 patients; RR 0.91, 95% CI 0.82 to 1.01). Eleven per cent of patients in the once daily group failed to adhere to their medication regimen compared to 9% of patients in the conventional dosing group (6 studies, 1462 patients; RR 1.22, 95% CI 0.91 to 1.64). There does not appear to be any difference in efficacy among the various 5-ASA formulations. Forty-four per cent of patients in the 5-ASA group relapsed compared to 41% of patients in the 5-ASA comparator group (6 studies, 707 patients; RR 1.08, 95% CI 0.91 to 1.28). A pooled analysis of two studies showed no statistically significant difference in efficacy between Balsalazide 6 g and 3 g/day. Twenty-three per cent of patients in the 6 g/day group relapsed compared to 33% of patients in the 3 g/day group (216 patients; RR 0.76; 95% CI 0.45 to 2.79). One study found Balsalazide 4 g to be superior to 2 g/day. Thirty-seven per cent of patients in the 4 g/day Balsalazide group relapsed compared to 55% of patients in the 2 g/day group (133 patients; RR 0.66; 95% CI 0.45 to 0.97). One study found a statistically significant difference between Salofalk granules 3 g and 1.5 g/day. Twenty-five per cent of patients in the Salofalk 3 g/day group relapsed compared to 39% of patients in the 1.5 g/day group (429 patients; RR 0.65; 95% CI 0.49 to 0.86). Common adverse events included flatulence, abdominal pain, nausea, diarrhea, headache, dyspepsia, and nasopharyngitis. There were no statistically significant differences in the incidence of adverse events between 5-ASA and placebo, 5-ASA and SASP, once daily and conventionally dosed 5-ASA, 5-ASA and comparator 5-ASA formulations and 5-ASA dose ranging studies. The trials that compared 5-ASA and SASP may have been biased in favour of SASP because most trials enrolled patients known to be tolerant to SASP which may have minimized SASP-related adverse events. 5-ASA was superior to placebo for maintenance therapy in ulcerative colitis. However, 5-ASA had a statistically significant therapeutic inferiority relative to SASP. Oral 5-ASA administered once daily is as effective and safe as conventional dosing for maintenance of remission in quiescent ulcerative colitis. There does not appear to be any difference in efficacy or safety between the various formulations of 5-ASA. Patients with extensive ulcerative colitis or with frequent relapses may benefit from a higher dose of maintenance therapy. High dose therapy appears to be as safe as low dose and is not associated with a higher incidence of adverse events.

Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism.

PubMed

Wang, Rong; Yu, Zhen; Sunchu, Bharath; Shoaf, James; Dang, Ivana; Zhao, Stephanie; Caples, Kelsey; Bradley, Lynda; Beaver, Laura M; Ho, Emily; Löhr, Christiane V; Perez, Viviana I

2017-06-01

Senescent cells contribute to age-related pathology and loss of function, and their selective removal improves physiological function and extends longevity. Rapamycin, an inhibitor of mTOR, inhibits cell senescence in vitro and increases longevity in several species. Nrf2 levels have been shown to decrease with aging and silencing Nrf2 gene induces premature senescence. Therefore, we explored whether Nrf2 is involved in the mechanism by which rapamycin delays cell senescence. In wild-type (WT) mouse fibroblasts, rapamycin increased the levels of Nrf2, and this correlates with the activation of autophagy and a reduction in the induction of cell senescence, as measured by SA-β-galactosidase (β-gal) staining, senescence-associated secretory phenotype (SASP), and p16 and p21 molecular markers. In Nrf2KO fibroblasts, however, rapamycin still decreased β-gal staining and the SASP, but rapamycin did not activate the autophagy pathway or decrease p16 and p21 levels. These observations were further confirmed in vivo using Nrf2KO mice, where rapamycin treatment led to a decrease in β-gal staining and pro-inflammatory cytokines in serum and fat tissue; however, p16 levels were not significantly decreased in fat tissue. Consistent with literature demonstrating that the Stat3 pathway is linked to the production of SASP, we found that rapamycin decreased activation of the Stat3 pathway in cells or tissue samples from both WT and Nrf2KO mice. Our data thus suggest that cell senescence is a complex process that involves at least two arms, and rapamycin uses Nrf2 to regulate cell cycle arrest, but not the production of SASP. © 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson’s disease?

PubMed Central

Chinta, Shankar J; Lieu, Christopher A; DeMaria, Marco; Laberge, Remi-Martin; Campisi, Judith; Andersen, Julie K

2013-01-01

Exposure to environmental toxins is associated with a variety of age-related diseases including cancer and neurodegeneration. For example, in Parkinson’s disease (PD), chronic environmental exposure to certain toxins has been linked to the age-related development of neuropathology. Neuronal damage is believed to involve the induction of neuroinflammatory events as a consequence of glial cell activation. Cellular senescence is a potent anti-cancer mechanism that occurs in a number of proliferative cell types and causes the arrest of proliferation of cells at risk of malignant transformation following exposure to potentially oncogenic stimuli. With age, senescent cells accumulate and express a senescence-associated secretory phenotype (SASP; i.e. the robust secretion of many inflammatory cytokines, growth factors and proteases). Whereas cell senescence in peripheral tissues has been causally linked to a number of age-related pathologies, little is known about the induction of cellular senescence and the SASP in the brain. Based on recently reported findings, we propose that environmental stressors associated with PD may act in part by eliciting senescence and the SASP within non-neuronal glial cells in the ageing brain, thus contributing to the characteristic decline in neuronal integrity that occurs in this disorder. PMID:23600398

The Potential Role of Senescence As a Modulator of Platelets and Tumorigenesis

PubMed Central

Valenzuela, Claudio A.; Quintanilla, Ricardo; Moore-Carrasco, Rodrigo; Brown, Nelson E.

2017-01-01

In addition to thrombus formation, alterations in platelet function are frequently observed in cancer patients. Importantly, both thrombus and tumor formation are influenced by age, although the mechanisms through which physiological aging modulates these processes remain poorly understood. In this context, the potential effects of senescent cells on platelet function represent pathophysiological mechanisms that deserve further exploration. Cellular senescence has traditionally been viewed as a barrier to tumorigenesis. However, far from being passive bystanders, senescent cells are metabolically active and able to secrete a variety of soluble and insoluble factors. This feature, known as the senescence-associated secretory phenotype (SASP), may provide senescent cells with the capacity to modify the tissue environment and, paradoxically, promote proliferation and neoplastic transformation of neighboring cells. In fact, the SASP-dependent ability of senescent cells to enhance tumorigenesis has been confirmed in cellular systems involving epithelial cells and fibroblasts, leaving open the question as to whether similar interactions can be extended to other cellular contexts. In this review, we discuss the diverse functions of platelets in tumorigenesis and suggest the possibility that senescent cells might also influence tumorigenesis through their ability to modulate the functional status of platelets through the SASP. PMID:28894697

Oral 5-aminosalicylic acid for induction of remission in ulcerative colitis.

PubMed

Feagan, Brian G; Macdonald, John K

2012-10-17

Oral 5-aminosalicylic acid (5-ASA) preparations were intended to avoid the adverse effects of sulfasalazine (SASP) while maintaining its therapeutic benefits. Previously, it was found that 5-ASA drugs in doses of at least 2 g/day, were more effective than placebo but no more effective than SASP for inducing remission in ulcerative colitis. This updated review includes more recent studies and evaluates the efficacy and safety of 5-ASA preparations used for the treatment of mild to moderately active ulcerative colitis. The primary objectives were to assess the efficacy, dose-responsiveness and safety of oral 5-ASA compared to placebo, SASP, or 5-ASA comparators for induction of remission in active ulcerative colitis. A secondary objective of this systematic review was to compare the efficacy and safety of once daily dosing of oral 5-ASA with conventional (two or three times daily) dosing regimens. A computer-assisted literature search for relevant studies (inception to January 20, 2012) was performed using MEDLINE, EMBASE and the Cochrane Library. Review articles and conference proceedings were also searched to identify additional studies. Studies were accepted for analysis if they were randomized controlled clinical trials of parallel design, with a minimum treatment duration of four weeks. Studies of oral 5-ASA therapy for treatment of patients with active ulcerative colitis compared with placebo, SASP or other formulations of 5-ASA were considered for inclusion. Studies that compared once daily 5-ASA treatment with conventional dosing of 5-ASA (two or three times daily) and 5-ASA dose ranging studies were also considered for inclusion. The outcomes of interest were the failure to induce global/clinical remission, global/clinical improvement, endoscopic remission, endoscopic improvement, adherence, adverse events, withdrawals due to adverse events, and withdrawals or exclusions after entry. Trials were separated into five comparison groups: 5-ASA versus placebo, 5-ASA versus sulfasalazine, once daily dosing versus conventional dosing, 5-ASA versus comparator 5-ASA, and 5-ASA dose-ranging. Placebo-controlled trials were subgrouped by dosage. SASP-controlled trials were subgrouped by 5-ASA/SASP mass ratios. Once daily versus conventional dosing studies were subgrouped by formulation. 5-ASA-controlled trials were subgrouped by common 5-ASA comparators (e.g. Asacol, Claversal, Salofalk and Pentasa). Dose-ranging studies were subgrouped by 5-ASA formulation. We calculated the relative risk (RR) and 95% confidence intervals (95% CI) for each outcome. Data were analyzed on an intention to treat basis. Forty-eight studies (7776 patients) were included. The majority of included studies were rated as low risk of bias. 5-ASA was significantly superior to placebo with regard to all measured outcome variables. Seventy-two per cent of 5-ASA patients failed to enter clinical remission compared to 85% of placebo patients (RR 0.86, 95% CI 0.81 to 0.91). A dose-response trend for 5-ASA was also observed. No statistically significant differences in efficacy were found between 5-ASA and SASP. Fifty-four per cent of 5-ASA patients failed to enter remission compared to 58% of SASP patients (RR 0.90, 95% CI 0.77 to 1.04). No statistically significant differences in efficacy or adherence were found between once daily and conventionally dosed 5-ASA. Forty-two per cent of once daily patients failed to enter clinical remission compared to 44% of conventionally dosed patients (RR 0.95, 95% CI 0.82 to 1.10). Eight per cent of patients dosed once daily failed to adhere to their medication regimen compared to 6% of conventionally dosed patients (RR 1.36, 95% CI 0.64 to 2.86). There does not appear to be any difference in efficacy among the various 5-ASA formulations. Forty-eight per cent of patients in the 5-ASA group failed to enter remission compared to 50% of patients in the 5-ASA comparator group (RR 0.94, 95% CI 0.86 to 1.03). A pooled analysis of the ASCEND (I, II and III, n = 1459 patients) studies found no statistically significant difference in clinical improvement between Asacol 4.8 g/day and 2.4 g/day used for the treatment of moderately active ulcerative colitis. Thirty-seven per cent of patients in the 4.8 g/day group failed to improve clinically compared to 41% of patients in the 2.4 g/day group (RR 0.89; 95% CI 0.78 to 1.01). Subgroup analysis indicated that patients with moderate disease may benefit from the higher dose of 4.8 g/day. One study compared (n = 123 patients) Pentasa 4 g/day to 2.25 g/day in patients with moderate disease. Twenty-five per cent of patients in the 4 g/day group failed to improve clinically compared to 57% of patients in the 2.25 g/day group (RR 0.44; 95% CI 0.27 to 0.71). A pooled analysis of two studies comparing MMX mesalamine 4.8 g/day to 2.4 g/day found no statistically significant difference in efficacy (RR 1.03, 95% CI 0.82 to 1.29). 5-ASA was generally safe and common adverse events included flatulence, abdominal pain, nausea, diarrhea, headache and worsening ulcerative colitis. There were no statistically significant differences in the incidence of adverse events between 5-ASA and placebo, once daily and conventionally dosed 5-ASA, 5-ASA and comparator 5-ASA formulation and 5-ASA dose ranging (high dose versus low dose) studies. SASP was not as well tolerated as 5-ASA. Twenty-nine percent of SASP patients experienced an adverse event compared to 15% of 5-ASA patients (RR 0.48, 95% CI 0.37 to 0.63). 5-ASA was superior to placebo and no more effective than SASP. Considering their relative costs, a clinical advantage to using oral 5-ASA in place of SASP appears unlikely. 5-ASA dosed once daily appears to be as efficacious and safe as conventionally dosed 5-ASA. Adherence does not appear to be enhanced by once daily dosing in the clinical trial setting. It is unknown if once daily dosing of 5-ASA improves adherence in a community-based setting. There do not appear to be any differences in efficacy or safety among the various 5-ASA formulations. A daily dosage of 2.4 g appears to be a safe and effective induction therapy for patients with mild to moderately active ulcerative colitis. Patients with moderate disease may benefit from an initial dose of 4.8 g/day.

Oral 5-aminosalicylic acid for induction of remission in ulcerative colitis.

PubMed

Wang, Yongjun; Parker, Claire E; Bhanji, Tania; Feagan, Brian G; MacDonald, John K

2016-04-21

Oral 5-aminosalicylic acid (5-ASA) preparations were intended to avoid the adverse effects of sulfasalazine (SASP) while maintaining its therapeutic benefits. Previously, it was found that 5-ASA drugs in doses of at least 2 g/day, were more effective than placebo but no more effective than SASP for inducing remission in ulcerative colitis. This updated review includes more recent studies and evaluates the efficacy and safety of 5-ASA preparations used for the treatment of mild to moderately active ulcerative colitis. The primary objectives were to assess the efficacy, dose-responsiveness and safety of oral 5-ASA compared to placebo, SASP, or 5-ASA comparators for induction of remission in active ulcerative colitis. A secondary objective of this systematic review was to compare the efficacy and safety of once daily dosing of oral 5-ASA with conventional (two or three times daily) dosing regimens. A computer-assisted literature search for relevant studies (inception to July 9, 2015) was performed using MEDLINE, EMBASE and the Cochrane Library. Review articles and conference proceedings were also searched to identify additional studies. Studies were accepted for analysis if they were randomized controlled clinical trials of parallel design, with a minimum treatment duration of four weeks. Studies of oral 5-ASA therapy for treatment of patients with active ulcerative colitis compared with placebo, SASP or other formulations of 5-ASA were considered for inclusion. Studies that compared once daily 5-ASA treatment with conventional dosing of 5-ASA (two or three times daily) and 5-ASA dose ranging studies were also considered for inclusion. The outcomes of interest were the failure to induce global/clinical remission, global/clinical improvement, endoscopic remission, endoscopic improvement, adherence, adverse events, withdrawals due to adverse events, and withdrawals or exclusions after entry. Trials were separated into five comparison groups: 5-ASA versus placebo, 5-ASA versus sulfasalazine, once daily dosing versus conventional dosing, 5-ASA versus comparator 5-ASA, and 5-ASA dose-ranging. Placebo-controlled trials were subgrouped by dosage. SASP-controlled trials were subgrouped by 5-ASA/SASP mass ratios. Once daily versus conventional dosing studies were subgrouped by formulation. 5-ASA-controlled trials were subgrouped by common 5-ASA comparators (e.g. Asacol, Claversal, Salofalk and Pentasa). Dose-ranging studies were subgrouped by 5-ASA formulation. We calculated the relative risk (RR) and 95% confidence intervals (95% CI) for each outcome. Data were analyzed on an intention-to-treat basis. Fifty-three studies (8548 patients) were included. The majority of included studies were rated as low risk of bias. 5-ASA was significantly superior to placebo with regard to all measured outcome variables. Seventy-one per cent of 5-ASA patients failed to enter clinical remission compared to 83% of placebo patients (RR 0.86, 95% CI 0.82 to 0.89). A dose-response trend for 5-ASA was also observed. No statistically significant differences in efficacy were found between 5-ASA and SASP. Fifty-four per cent of 5-ASA patients failed to enter remission compared to 58% of SASP patients (RR 0.90, 95% CI 0.77 to 1.04). No statistically significant differences in efficacy or adherence were found between once daily and conventionally dosed 5-ASA. Forty-five per cent of once daily patients failed to enter clinical remission compared to 48% of conventionally dosed patients (RR 0.94, 95% CI 0.83 to 1.07). Eight per cent of patients dosed once daily failed to adhere to their medication regimen compared to 6% of conventionally dosed patients (RR 1.36, 95% CI 0.64 to 2.86). There does not appear to be any difference in efficacy among the various 5-ASA formulations. Fifty per cent of patients in the 5-ASA group failed to enter remission compared to 52% of patients in the 5-ASA comparator group (RR 0.94, 95% CI 0.86 to 1.02). A pooled analysis of 3 studies (n = 1459 patients) studies found no statistically significant difference in clinical improvement between Asacol 4.8 g/day and 2.4 g/day used for the treatment of moderately active ulcerative colitis. Thirty-seven per cent of patients in the 4.8 g/day group failed to improve clinically compared to 41% of patients in the 2.4 g/day group (RR 0.89; 95% CI 0.78 to 1.01). Subgroup analysis indicated that patients with moderate disease may benefit from the higher dose of 4.8 g/day. One study compared (n = 123 patients) Pentasa 4 g/day to 2.25 g/day in patients with moderate disease. Twenty-five per cent of patients in the 4 g/day group failed to improve clinically compared to 57% of patients in the 2.25 g/day group (RR 0.44; 95% CI 0.27 to 0.71). A pooled analysis of two studies comparing MMX mesalamine 4.8 g/day to 2.4 g/day found no statistically significant difference in efficacy (RR 1.03, 95% CI 0.82 to 1.29). There were no statistically significant differences in the incidence of adverse events between 5-ASA and placebo, once daily and conventionally dosed 5-ASA, 5-ASA and comparator 5-ASA formulation and 5-ASA dose ranging (high dose versus low dose) studies. Common adverse events included flatulence, abdominal pain, nausea, diarrhea, headache and worsening ulcerative colitis. SASP was not as well tolerated as 5-ASA. Twenty-nine percent of SASP patients experienced an adverse event compared to 15% of 5-ASA patients (RR 0.48, 95% CI 0.37 to 0.63). 5-ASA was superior to placebo and no more effective than SASP. Considering their relative costs, a clinical advantage to using oral 5-ASA in place of SASP appears unlikely. 5-ASA dosed once daily appears to be as efficacious and safe as conventionally dosed 5-ASA. Adherence does not appear to be enhanced by once daily dosing in the clinical trial setting. It is unknown if once daily dosing of 5-ASA improves adherence in a community-based setting. There do not appear to be any differences in efficacy or safety among the various 5-ASA formulations. A daily dosage of 2.4 g appears to be a safe and effective induction therapy for patients with mild to moderately active ulcerative colitis. Patients with moderate disease may benefit from an initial dose of 4.8 g/day.

The Impacts of Cellular Senescence in Elderly Pneumonia and in Age-Related Lung Diseases That Increase the Risk of Respiratory Infections.

PubMed

Yanagi, Shigehisa; Tsubouchi, Hironobu; Miura, Ayako; Matsuo, Ayako; Matsumoto, Nobuhiro; Nakazato, Masamitsu

2017-02-25

Pneumonia generates considerable negative impacts on the elderly. Despite the widespread uses of vaccines and appropriate antibiotics, the morbidity and mortality of elderly pneumonia are significantly higher compared to the counterparts of young populations. The definitive mechanisms of high vulnerability in the elderly against pathogen threats are unclear. Age-associated, chronic low-grade inflammation augments the susceptibility and severity of pneumonia in the elderly. Cellular senescence, one of the hallmarks of aging, has its own characteristics, cell growth arrest and senescence-associated secretory phenotype (SASP). These properties are beneficial if the sequence of senescence-clearance-regeneration is transient in manner. However, persisting senescent cell accumulation and excessive SASP might induce sustained low-grade inflammation and disruption of normal tissue microenvironments in aged tissue. Emerging evidence indicates that cellular senescence is a key component in the pathogenesis of chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), which are known to be age-related and increase the risk of pneumonia. In addition to their structural collapses, COPD and IPF might increase the vulnerability to pathogen insults through SASP. Here, we discuss the current advances in understanding of the impacts of cellular senescence in elderly pneumonia and in these chronic lung disorders that heighten the risk of respiratory infections.

Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson's disease?

PubMed

Chinta, S J; Lieu, C A; Demaria, M; Laberge, R-M; Campisi, J; Andersen, J K

2013-05-01

Exposure to environmental toxins is associated with a variety of age-related diseases including cancer and neurodegeneration. For example, in Parkinson's disease (PD), chronic environmental exposure to certain toxins has been linked to the age-related development of neuropathology. Neuronal damage is believed to involve the induction of neuroinflammatory events as a consequence of glial cell activation. Cellular senescence is a potent anti-cancer mechanism that occurs in a number of proliferative cell types and causes the arrest of proliferation of cells at risk of malignant transformation following exposure to potentially oncogenic stimuli. With age, senescent cells accumulate and express a senescence-associated secretory phenotype (SASP; that is the robust secretion of many inflammatory cytokines, growth factors and proteases). Whereas cell senescence in peripheral tissues has been causally linked to a number of age-related pathologies, little is known about the induction of cellular senescence and the SASP in the brain. On the basis of recently reported findings, we propose that environmental stressors associated with PD may act in part by eliciting senescence and the SASP within non neuronal glial cells in the ageing brain, thus contributing to the characteristic decline in neuronal integrity that occurs in this disorder. © 2013 The Association for the Publication of the Journal of Internal Medicine.

Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans.

PubMed

Carroll, Judith E; Cole, Steven W; Seeman, Teresa E; Breen, Elizabeth C; Witarama, Tuff; Arevalo, Jesusa M G; Ma, Jeffrey; Irwin, Michael R

2016-01-01

Age-related disease risk has been linked to short sleep duration and sleep disturbances; however, the specific molecular pathways linking sleep loss with diseases of aging are poorly defined. Key cellular events seen with aging, which are thought to contribute to disease, may be particularly sensitive to sleep loss. We tested whether one night of partial sleep deprivation (PSD) would increase leukocyte gene expression indicative of DNA damage responses (DDR), the senescence-associated secretory phenotype (SASP), and senescence indicator p16(INK4a) in older adult humans, who are at increased risk for cellular senescence. Community-dwelling older adults aged 61-86years (n=29; 48% male) underwent an experimental partial sleep deprivation (PSD) protocol over 4 nights, including adaptation, an uninterrupted night of sleep, partial sleep deprivation (sleep restricted 3-7AM), and a subsequent full night of sleep. Blood samples were obtained each morning to assess peripheral blood mononuclear cell (PBMC) gene expression using Illumina HT-12 arrays. Analyses of microarray results revealed that SASP (p<.05) and DDR (p=.08) gene expression were elevated from baseline to PSD nights. Gene expression changes were also observed from baseline to PSD in NFKB2, NBS1 and CHK2 (all p's<.05). The senescence marker p16(INK4a) (CDKN2A) was increased 1day after PSD compared to baseline (p<.01), however confirmatory RT-PCR did not replicate this finding. One night of partial sleep deprivation activates PBMC gene expression patterns consistent with biological aging in this older adult sample. PSD enhanced the SASP and increased the accumulation of damage that initiates cell cycle arrest and promotes cellular senescence. These findings causally link sleep deprivation to the molecular processes associated with biological aging. Copyright © 2015 Elsevier Inc. All rights reserved.

RNA-binding Protein Immunoprecipitation (RIP) to Examine AUF1 Binding to Senescence-Associated Secretory Phenotype (SASP) Factor mRNA

PubMed Central

Alspach, Elise; Stewart, Sheila A.

2016-01-01

Immunoprecipitation and subsequent isolation of nucleic acids allows for the investigation of protein:nucleic acid interactions. RNA-binding protein immunoprecipitation (RIP) is used for the analysis of protein interactions with mRNA. Combining RIP with quantitative real-time PCR (qRT-PCR) further enhances the RIP technique by allowing for the quantitative assessment of RNA-binding protein interactions with their target mRNAs, and how these interactions change in different cellular settings. Here, we describe the immunoprecipitation of the RNA-binding protein AUF1 with several different factors associated with the senescence-associated secretory phenotype (SASP) (Alspach and Stewart, 2013), specifically IL6 and IL8. This protocol was originally published in Alspach et al. (2014). PMID:27453911

Long-term efficacy and safety of once-daily mesalazine granules for the treatment of active ulcerative colitis

PubMed Central

Böhm, Stephan Karl; Kruis, Wolfgang

2014-01-01

In 1977, 5-aminosalicylic acid (5-ASA) was discovered as a therapeutically active moiety of sulfasalazine (SASP) and was launched for topical and oral therapy of ulcerative colitis (UC) in 1984. As a first-step, delivery systems had to be developed to protect 5-ASA against absorption in the upper gastrointestinal tract, resulting in different and competing strategies (azo compounds, controlled release, and pH-dependent release). In a second step, at the beginning of the new century, coinciding with the expiration of patent protection for the first 5-ASA formulations, two component composite release mechanisms (pH-dependent and controlled release) were developed. Furthermore, the drug was formulated as granules instead of tablets, allowing higher unit strengths compared with tablets. Neither Salofalk Granu-Stix®, nor MMX 5-ASA, nor Pentasa® granules have initially been developed for once-daily (OD) dosing. A review of the achievements of 20 years of 5-ASA development has demonstrated that 5-ASA has equal efficacy compared with SASP at best, that there are no measurable differences in efficacy between various 5-ASA preparations, and that in a group of patients tolerating SASP, adverse event profiles of SASP and 5-ASA did not differ significantly, with SASP being the far cheaper substance. Therefore, drug adherence came into focus as a new goal for improving UC therapy. Although adherence is a complex and multifactorial construct, a simple dosing schedule may contribute to higher drug adherence and better efficacy of treatment. Simultaneously, the US 5-ASA market, estimated to be worth US$1.4 billion, is expected to grow continuously. Naturally, this very competitive market is not only driven by scientific progress but also by commercial interests. Thus, patents for minor changes to the formulation may serve as protection against drug companies trying to launch generic versions. Randomized controlled trials performed on OD dosing in induction of remission have demonstrated that OD administration of 5-ASA is as effective as conventional dosing in mild to moderate active UC. The three 5-ASA products MMX, Salofalk®, and Pentasa® employed in those studies so far have not shown differences in efficacy between OD and conventional dosing. No differences regarding safety outcomes have been detected between OD and conventional dosing, including incidence of adverse events, serious adverse events, or withdrawal from treatment due to an adverse event. Although the majority of patients prefer OD dosing to conventional dosing, it was not possible to detect differences in adherence between OD and multiple dose regimens in the clinical trial setting. Well-designed and controlled large-scale community-based studies are necessary to further investigate and prove the point of improved long-term adherence and treatment efficacy in OD dosing. PMID:25285021

Blocking negative effects of senescence in human skin fibroblasts with a plant extract.

PubMed

Lämmermann, Ingo; Terlecki-Zaniewicz, Lucia; Weinmüllner, Regina; Schosserer, Markus; Dellago, Hanna; de Matos Branco, André Dargen; Autheried, Dominik; Sevcnikar, Benjamin; Kleissl, Lisa; Berlin, Irina; Morizot, Frédérique; Lejeune, Francois; Fuzzati, Nicola; Forestier, Sandra; Toribio, Alix; Tromeur, Anaïs; Weinberg, Lionel; Higareda Almaraz, Juan Carlos; Scheideler, Marcel; Rietveld, Marion; El Ghalbzouri, Abdoel; Tschachler, Erwin; Gruber, Florian; Grillari, Johannes

2018-01-01

There is increasing evidence that senescent cells are a driving force behind many age-related pathologies and that their selective elimination increases the life- and healthspan of mice. Senescent cells negatively affect their surrounding tissue by losing their cell specific functionality and by secreting a pro-tumorigenic and pro-inflammatory mixture of growth hormones, chemokines, cytokines and proteases, termed the senescence-associated secretory phenotype (SASP). Here we identified an extract from the plant Solidago virgaurea subsp. alpestris , which exhibited weak senolytic activity, delayed the acquisition of a senescent phenotype and induced a papillary phenotype with improved functionality in human dermal fibroblasts. When administered to stress-induced premature senescent fibroblasts, this extract changed their global mRNA expression profile and particularly reduced the expression of various SASP components, thereby ameliorating the negative influence on nearby cells. Thus, the investigated plant extract represents a promising possibility to block age-related loss of tissue functionality.

Site-Directed Mutagenesis and Structural Studies Suggest that the Germination Protease, GPR, in Spores of Bacillus Species Is an Atypical Aspartic Acid Protease

PubMed Central

Carroll, Thomas M.; Setlow, Peter

2005-01-01

Germination protease (GPR) initiates the degradation of small, acid-soluble spore proteins (SASP) during germination of spores of Bacillus and Clostridium species. The GPR amino acid sequence is not homologous to members of the major protease families, and previous work has not identified residues involved in GPR catalysis. The current work has focused on identifying catalytically essential amino acids by mutagenesis of Bacillus megaterium gpr. A residue was selected for alteration if it (i) was conserved among spore-forming bacteria, (ii) was a potential nucleophile, and (iii) had not been ruled out as inessential for catalysis. GPR variants were overexpressed in Escherichia coli, and the active form (P41) was assayed for activity against SASP and the zymogen form (P46) was assayed for the ability to autoprocess to P41. Variants inactive against SASP and unable to autoprocess were analyzed by circular dichroism spectroscopy and multiangle laser light scattering to determine whether the variant's inactivity was due to loss of secondary or quaternary structure, respectively. Variation of D127 and D193, but no other residues, resulted in inactive P46 and P41, while variants of each form were well structured and tetrameric, suggesting that D127 and D193 are essential for activity and autoprocessing. Mapping these two aspartate residues and a highly conserved lysine onto the B. megaterium P46 crystal structure revealed a striking similarity to the catalytic residues and propeptide lysine of aspartic acid proteases. These data indicate that GPR is an atypical aspartic acid protease. PMID:16199582

41 CFR 102-37.405 - How often must a SASP update donee eligibility records?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Donations to Public Agencies, Service Educational Activities.... Annually, you must update files for nonprofit organizations whose eligibility depends on annual...

41 CFR 102-37.405 - How often must a SASP update donee eligibility records?

Code of Federal Regulations, 2011 CFR

2011-01-01

... Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Donations to Public Agencies, Service Educational Activities.... Annually, you must update files for nonprofit organizations whose eligibility depends on annual...

41 CFR 102-37.205 - What agreements must a SASP make?

Code of Federal Regulations, 2010 CFR

2010-07-01

... event of loss or damage due to negligence or willful misconduct on your part, repair, replace, or pay to... provided for by the Federal Tort Claims Act (28 U.S.C. 2671, et seq.). [67 FR 2584, Jan. 18, 2002, as...

41 CFR 102-37.345 - When must a SASP be audited?

Code of Federal Regulations, 2011 CFR

2011-01-01

... program should be identified by Catalog of Federal Domestic Assistance number 39.003 when completing the... audited? 102-37.345 Section 102-37.345 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF...

41 CFR 102-37.345 - When must a SASP be audited?

Code of Federal Regulations, 2012 CFR

2012-01-01

... program should be identified by Catalog of Federal Domestic Assistance number 39.003 when completing the... audited? 102-37.345 Section 102-37.345 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF...

41 CFR 102-37.345 - When must a SASP be audited?

Code of Federal Regulations, 2010 CFR

2010-07-01

... program should be identified by Catalog of Federal Domestic Assistance number 39.003 when completing the... audited? 102-37.345 Section 102-37.345 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF...

41 CFR 102-37.345 - When must a SASP be audited?

Code of Federal Regulations, 2014 CFR

2014-01-01

... program should be identified by Catalog of Federal Domestic Assistance number 39.003 when completing the... audited? 102-37.345 Section 102-37.345 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF...

41 CFR 102-37.345 - When must a SASP be audited?

Code of Federal Regulations, 2013 CFR

2013-07-01

... program should be identified by Catalog of Federal Domestic Assistance number 39.003 when completing the... audited? 102-37.345 Section 102-37.345 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF...

41 CFR 102-37.35 - Who handles the donation of surplus property?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Who handles the donation...-DONATION OF SURPLUS PERSONAL PROPERTY General Provisions Donation Overview § 102-37.35 Who handles the donation of surplus property? (a) The SASPs handle the donation of most surplus property to eligible donees...

41 CFR 102-37.485 - What actions must a SASP take if a review or other information indicates noncompliance with...

Code of Federal Regulations, 2010 CFR

2010-07-01

... take if a review or other information indicates noncompliance with donation terms and conditions? 102... Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Donations to Public Agencies, Service Educational Activities (SEAs), and Eligible Nonprofit...

41 CFR 102-37.500 - May a donee receive reimbursement for its donation expenses when unneeded property is returned to...

Code of Federal Regulations, 2010 CFR

2010-07-01

... reimbursement for its donation expenses when unneeded property is returned to the SASP? 102-37.500 Section 102... (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Donations to Public Agencies, Service Educational Activities (SEAs), and Eligible Nonprofit Organizations...

41 CFR 102-37.500 - May a donee receive reimbursement for its donation expenses when unneeded property is returned to...

Code of Federal Regulations, 2012 CFR

2012-01-01

... reimbursement for its donation expenses when unneeded property is returned to the SASP? 102-37.500 Section 102... (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Donations to Public Agencies, Service Educational Activities (SEAs), and Eligible Nonprofit Organizations...

41 CFR 102-37.485 - What actions must a SASP take if a review or other information indicates noncompliance with...

Code of Federal Regulations, 2014 CFR

2014-01-01

... take if a review or other information indicates noncompliance with donation terms and conditions? 102... Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Donations to Public Agencies, Service Educational Activities (SEAs), and Eligible Nonprofit...

41 CFR 102-37.485 - What actions must a SASP take if a review or other information indicates noncompliance with...

Code of Federal Regulations, 2013 CFR

2013-07-01

... take if a review or other information indicates noncompliance with donation terms and conditions? 102... Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Donations to Public Agencies, Service Educational Activities (SEAs), and Eligible Nonprofit...

41 CFR 102-37.500 - May a donee receive reimbursement for its donation expenses when unneeded property is returned to...

Code of Federal Regulations, 2011 CFR

2011-01-01

... reimbursement for its donation expenses when unneeded property is returned to the SASP? 102-37.500 Section 102... (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Donations to Public Agencies, Service Educational Activities (SEAs), and Eligible Nonprofit Organizations...

41 CFR 102-37.485 - What actions must a SASP take if a review or other information indicates noncompliance with...

Code of Federal Regulations, 2011 CFR

2011-01-01

... take if a review or other information indicates noncompliance with donation terms and conditions? 102... Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Donations to Public Agencies, Service Educational Activities (SEAs), and Eligible Nonprofit...

41 CFR 102-37.35 - Who handles the donation of surplus property?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Who handles the donation...-DONATION OF SURPLUS PERSONAL PROPERTY General Provisions Donation Overview § 102-37.35 Who handles the donation of surplus property? (a) The SASPs handle the donation of most surplus property to eligible donees...

41 CFR 102-37.500 - May a donee receive reimbursement for its donation expenses when unneeded property is returned to...

Code of Federal Regulations, 2013 CFR

2013-07-01

... reimbursement for its donation expenses when unneeded property is returned to the SASP? 102-37.500 Section 102... (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Donations to Public Agencies, Service Educational Activities (SEAs), and Eligible Nonprofit Organizations...

41 CFR 102-37.35 - Who handles the donation of surplus property?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false Who handles the donation...-DONATION OF SURPLUS PERSONAL PROPERTY General Provisions Donation Overview § 102-37.35 Who handles the donation of surplus property? (a) The SASPs handle the donation of most surplus property to eligible donees...

41 CFR 102-37.485 - What actions must a SASP take if a review or other information indicates noncompliance with...

Code of Federal Regulations, 2012 CFR

2012-01-01

... take if a review or other information indicates noncompliance with donation terms and conditions? 102... Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Donations to Public Agencies, Service Educational Activities (SEAs), and Eligible Nonprofit...

41 CFR 102-37.35 - Who handles the donation of surplus property?

Code of Federal Regulations, 2014 CFR

2014-01-01

... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false Who handles the donation...-DONATION OF SURPLUS PERSONAL PROPERTY General Provisions Donation Overview § 102-37.35 Who handles the donation of surplus property? (a) The SASPs handle the donation of most surplus property to eligible donees...

41 CFR 102-37.35 - Who handles the donation of surplus property?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Who handles the donation...-DONATION OF SURPLUS PERSONAL PROPERTY General Provisions Donation Overview § 102-37.35 Who handles the donation of surplus property? (a) The SASPs handle the donation of most surplus property to eligible donees...

41 CFR 102-37.500 - May a donee receive reimbursement for its donation expenses when unneeded property is returned to...

Code of Federal Regulations, 2014 CFR

2014-01-01

... reimbursement for its donation expenses when unneeded property is returned to the SASP? 102-37.500 Section 102... (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Donations to Public Agencies, Service Educational Activities (SEAs), and Eligible Nonprofit Organizations...

78 FR 43918 - Agency Information Collection Activities: Extension of a Currently Approved Collection Semi...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-22

... Program. The Sexual Assault Services Program (SASP), created by the Violence Against Women Act of 2005... of a Currently Approved Collection Semi-Annual Progress Report for the Tribal Sexual Assault Services Program ACTION: 60-Day Notice. The Department of Justice, Office on Violence Against Women (OVW) will be...

Statistical modeling of SRAM yield performance and circuit variability

NASA Astrophysics Data System (ADS)

Cheng, Qi; Chen, Yijian

2015-03-01

In this paper, we develop statistical models to investigate SRAM yield performance and circuit variability in the presence of self-aligned multiple patterning (SAMP) process. It is assumed that SRAM fins are fabricated by a positivetone (spacer is line) self-aligned sextuple patterning (SASP) process which accommodates two types of spacers, while gates are fabricated by a more pitch-relaxed self-aligned quadruple patterning (SAQP) process which only allows one type of spacer. A number of possible inverter and SRAM structures are identified and the related circuit multi-modality is studied using the developed failure-probability and yield models. It is shown that SRAM circuit yield is significantly impacted by the multi-modality of fins' spatial variations in a SRAM cell. The sensitivity of 6-transistor SRAM read/write failure probability to SASP process variations is calculated and the specific circuit type with the highest probability to fail in the reading/writing operation is identified. Our study suggests that the 6-transistor SRAM configuration may not be scalable to 7-nm half pitch and more robust SRAM circuit design needs to be researched.

Telomere Damage Response and Low-Grade Inflammation.

PubMed

Wang, Lihui; Yu, Xianhua; Liu, Jun-Ping

2017-01-01

Telomeres at the ends of chromosomes safeguard genome integrity and stability in human nucleated cells. However, telomere repeats shed off during cell proliferation and other stress responses. Our recent studies show that telomere attrition induces not only epithelial stem cell senescence but also low-grade inflammation in the lungs. The senescence-associated low-grade inflammation (SALI) is characteristic of alveolar stem cell replicative senescence, increased proinflammatory and anti-inflammatory cytokines, infiltrated immune cells, and spillover effects. To date, the mechanisms underlying SALI remain unclear. Investigations demonstrate that senescent epithelial stem cells with telomere erosion are not the source of secreted cytokines, containing no significant increase in expression of the genes coding for increased cytokines, suggesting an alternative senescence-associated secretory phenotype (A-SASP). Given that telomere loss results in significant alterations in the genomes and accumulations of the cleaved telomeric DNA in the cells and milieu externe, we conclude that telomere position effects (TPEs) on gene expression and damage-associated molecular patterns (DAMPs) in antigen presentation are involved in A-SASP and SALI in response to telomere damage in mammals.

Evolutionary space platform concept study. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

1982-01-01

The Evolutionary Space Platform Concept Study encompassed a 10 month effort to define, evaluate and compare approaches and concepts for evolving unmanned and manned capability platforms beyond the current Space Platform concepts to an evolutionary goal of establishing a permanent manned presence in space. Areas addressed included: special emphasis trade studies on the current unmanned concept, assessment of manned platform concepts, and utility analysis of a manned platform for defense related missions.

41 CFR 102-37.210 - Must a SASP make a drug-free workplace certification when requesting surplus property for donation?

Code of Federal Regulations, 2010 CFR

2010-07-01

...-free workplace certification when requesting surplus property for donation? 102-37.210 Section 102-37...) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY State Agency for... workplace certification when requesting surplus property for donation? No, you must certify that you will...

41 CFR 102-37.210 - Must a SASP make a drug-free workplace certification when requesting surplus property for donation?

Code of Federal Regulations, 2014 CFR

2014-01-01

...-free workplace certification when requesting surplus property for donation? 102-37.210 Section 102-37...) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY State Agency for... workplace certification when requesting surplus property for donation? No, you must certify that you will...

41 CFR 102-37.210 - Must a SASP make a drug-free workplace certification when requesting surplus property for donation?

Code of Federal Regulations, 2013 CFR

2013-07-01

...-free workplace certification when requesting surplus property for donation? 102-37.210 Section 102-37...) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY State Agency for... workplace certification when requesting surplus property for donation? No, you must certify that you will...

41 CFR 102-37.210 - Must a SASP make a drug-free workplace certification when requesting surplus property for donation?

Code of Federal Regulations, 2011 CFR

2011-01-01

...-free workplace certification when requesting surplus property for donation? 102-37.210 Section 102-37...) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY State Agency for... workplace certification when requesting surplus property for donation? No, you must certify that you will...

41 CFR 102-37.210 - Must a SASP make a drug-free workplace certification when requesting surplus property for donation?

Code of Federal Regulations, 2012 CFR

2012-01-01

...-free workplace certification when requesting surplus property for donation? 102-37.210 Section 102-37...) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY State Agency for... workplace certification when requesting surplus property for donation? No, you must certify that you will...

41 CFR Appendix B to Part 102 - 37-Elements of a State Plan of Operation

Code of Federal Regulations, 2010 CFR

2010-07-01

... direct and reasonable indirect costs of its activities, the method of establishing the charges must be... available to nonprofit providers of assistance to homeless individuals be distributed at a nominal cost for... other sources such as sales or compliance proceeds are to be used for the operation of the SASP and the...

Assembly Platform For Use In Outer Space

NASA Technical Reports Server (NTRS)

Rao, Niranjan S.; Buddington, Patricia A.

1995-01-01

Report describes conceptual platform or framework for use in assembling other structures and spacecraft in outer space. Consists of three fixed structural beams comprising central beam and two cross beams. Robotic manipulators spaced apart on platform to provide telerobotic operation of platform by either space-station or ground crews. Platform and attached vehicles function synergistically to achieve maximum performance for intended purposes.

UAH/NASA Workshop on Space Science Platform

NASA Technical Reports Server (NTRS)

Wu, S. T. (Editor); Morgan, S. (Editor)

1978-01-01

The scientific user requirements for a space science platform were defined. The potential user benefits, technological implications and cost of space platforms were examined. Cost effectiveness of the platforms' capabilities were also examined.

Evolutionary space platform concept study. Volume 2, part B: Manned space platform concepts

NASA Technical Reports Server (NTRS)

1982-01-01

Logical, cost-effective steps in the evolution of manned space platforms are investigated and assessed. Tasks included the analysis of requirements for a manned space platform, identifying alternative concepts, performing system analysis and definition of the concepts, comparing the concepts and performing programmatic analysis for a reference concept.

Irradiation induces glioblastoma cell senescence and senescence-associated secretory phenotype.

PubMed

Jeon, Hee-Young; Kim, Jun-Kyum; Ham, Seok Won; Oh, Se-Yeong; Kim, Jaebong; Park, Jae-Bong; Lee, Jae-Yong; Kim, Sung-Chan; Kim, Hyunggee

2016-05-01

Glioblastoma multiforme (GBM) is one of the most aggressive and fatal primary brain tumors in humans. The standard therapy for the treatment of GBM is surgical resection, followed by radiotherapy and/or chemotherapy. However, the frequency of tumor recurrence in GBM patients is very high, and the survival rate remains poor. Delineating the mechanisms of GBM recurrence is essential for therapeutic advances. Here, we demonstrate that irradiation rendered 17-20 % of GBM cells dead, but resulted in 60-80 % of GBM cells growth-arrested with increases in senescence markers, such as senescence-associated beta-galactosidase-positive cells, H3K9me3-positive cells, and p53-p21(CIP1)-positive cells. Moreover, irradiation induced expression of senescence-associated secretory phenotype (SASP) mRNAs and NFκB transcriptional activity in GBM cells. Strikingly, compared to injection of non-irradiated GBM cells into immune-deficient mice, the co-injection of irradiated and non-irradiated GBM cells resulted in faster growth of tumors with the histological features of human GBM. Taken together, our findings suggest that the increases in senescent cells and SASP in GBM cells after irradiation is likely one of main reasons for tumor recurrence in post-radiotherapy GBM patients.

Orbiter processing facility: Access platforms Kennedy Space Center, Florida, from challenge to achievement

NASA Technical Reports Server (NTRS)

Haratunian, M.

1985-01-01

A system of access platforms and equipment within the space shuttle orbiter processing facility at Kennedy Space Center is described. The design challenges of the platforms, including clearance envelopes, load criteria, and movement, are discussed. Various applications of moveable platforms are considered.

Space Station

NASA Image and Video Library

1981-12-01

During 1980 and the first half of 1981, the Marshall Space Flight Center conducted studies concerned with a relatively low-cost, near-term, manned space platform to satisfy current user needs, yet capable of evolutionary growth to meet future needs. The Science and Application Manned Space Platform (SAMSP) studies were to serve as a test bed for developing scientific and operational capabilities required by later, more advanced manned platforms while accomplishing early science and operations. This concept illustrates a manned space platform.

Large Space Systems Technology, 1979. [antenna and space platform systems conference

NASA Technical Reports Server (NTRS)

Ward, J. C., Jr. (Compiler)

1980-01-01

Items of technology and developmental efforts in support of the large space systems technology programs are described. The major areas of interest are large antennas systems, large space platform systems, and activities that support both antennas and platform systems.

Space Station

NASA Image and Video Library

1982-01-01

McDornel Douglas performed an Evolutionary Space Platform Concept Study for the Marshall Space Flight Center in the early 1980's. The 10-month study was designed to define, evaluate, and compare approaches and concepts for evolving unmanned and manned capability platforms beyond the then current space platform concepts to an evolutionary goal of establishing a permanent-manned presence in space.

Reversing Breast Cancer-Induced Immune Suppression

DTIC Science & Technology

2014-01-01

same oxidative radicals that MDSC use to facilitate immune suppression. Nrf2 protects cells against inflammation and is stabilized in response to... inflammation , hypoxia, and other factors that are known inducers of MDSC. Since Nrf2 regulates antioxidant response and apoptosis, I hypothesize that... inflammation -induced and conventional MDSC transport of cystine. SASP has no effect on tumor growth, metastatic disease, MDSC accumulation, or MDSC suppressive

Reversing Breast Cancer-Induced Immune Suppression

DTIC Science & Technology

2013-01-01

MDSC use to facilitate immune suppression. Nrf2 protects cells against inflammation and is stabilized in response to inflammation , hypoxia, and... inflammation -induced and conventional MDSC transport of cystine. SASP has no effect on tumor growth, metastatic disease, MDSC accumulation, or MDSC...anti-tumor immunity. It has been demonstrated that inflammation enhances xC- expression on MDSC, but higher xC- expression does not enhance the

Depletion of HPV16 early genes induces autophagy and senescence in a cervical carcinogenesis model, regardless of viral physical state.

PubMed

Hanning, Jennifer E; Saini, Harpreet K; Murray, Matthew J; Caffarel, Maria M; van Dongen, Stijn; Ward, Dawn; Barker, Emily M; Scarpini, Cinzia G; Groves, Ian J; Stanley, Margaret A; Enright, Anton J; Pett, Mark R; Coleman, Nicholas

2013-11-01

In cervical carcinomas, high-risk human papillomavirus (HR-HPV) may be integrated into host chromosomes or remain extra-chromosomal (episomal). We used the W12 cervical keratinocyte model to investigate the effects of HPV16 early gene depletion on in vitro cervical carcinogenesis pathways, particularly effects shared by cells with episomal versus integrated HPV16 DNA. Importantly, we were able to study the specific cellular consequences of viral gene depletion by using short interfering RNAs known not to cause phenotypic or transcriptional off-target effects in keratinocytes. We found that while cervical neoplastic progression in vitro was characterized by dynamic changes in HPV16 transcript levels, viral early gene expression was required for cell survival at all stages of carcinogenesis, regardless of viral physical state, levels of early gene expression or histology in organotypic tissue culture. Moreover, HPV16 early gene depletion induced changes in host gene expression that were common to both episome-containing and integrant-containing cells. In particular, we observed up-regulation of autophagy genes, associated with enrichment of senescence and innate immune-response pathways, including the senescence-associated secretory phenotype (SASP). In keeping with these observations, HPV16 early gene depletion induced autophagy in both episome-containing and integrant-containing W12 cells, as evidenced by the appearance of autophagosomes, punctate expression of the autophagy marker LC3, conversion of LC3B-I to LC3B-II, and reduced levels of the autophagy substrate p62. Consistent with the reported association between autophagy and senescence pathways, HPV16 early gene depletion induced expression of the senescence marker beta-galactosidase and increased secretion of the SASP-related protein IGFBP3. Together, these data indicate that depleting HR-HPV early genes would be of potential therapeutic benefit in all cervical carcinogenesis pathways, regardless of viral physical state. In addition, the senescence/SASP response associated with autophagy induction may promote beneficial immune effects in bystander cells. Copyright © 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Regional variability in dust-on-snow processes and impacts in the Upper Colorado River Basin

USGS Publications Warehouse

Skiles, S. McKenzie; Painter, Thomas H.; Belnap, Jayne; Holland, Lacey; Reynolds, Richard L.; Goldstein, Harland L.; Lin, J.

2015-01-01

Dust deposition onto mountain snow cover in the Upper Colorado River Basin frequently occurs in the spring when wind speeds and dust emission peaks on the nearby Colorado Plateau. Dust loading has increased since the intensive settlement in the western USA in the mid 1880s. The effects of dust-on-snow have been well studied at Senator Beck Basin Study Area (SBBSA) in the San Juan Mountains, CO, the first high-altitude area of contact for predominantly southwesterly winds transporting dust from the southern Colorado Plateau. To capture variability in dust transport from the broader Colorado Plateau and dust deposition across a larger area of the Colorado River water sources, an additional study plot was established in 2009 on Grand Mesa, 150 km to the north of SBBSA in west central, CO. Here, we compare the 4-year (2010–2013) dust source, deposition, and radiative forcing records at Grand Mesa Study Plot (GMSP) and Swamp Angel Study Plot (SASP), SBBSA's subalpine study plot. The study plots have similar site elevations/environments and differ mainly in the amount of dust deposited and ensuing impacts. At SASP, end of year dust concentrations ranged from 0.83 mg g−1 to 4.80 mg g−1, and daily mean spring dust radiative forcing ranged from 50–65 W m−2, advancing melt by 24–49 days. At GMSP, which received 1.0 mg g−1 less dust per season on average, spring radiative forcings of 32–50 W m−2 advanced melt by 15–30 days. Remote sensing imagery showed that observed dust events were frequently associated with dust emission from the southern Colorado Plateau. Dust from these sources generally passed south of GMSP, and back trajectory footprints modelled for observed dust events were commonly more westerly and northerly for GMSP relative to SASP. These factors suggest that although the southern Colorado Plateau contains important dust sources, dust contributions from other dust sources contribute to dust loading in this region, and likely account for the majority of dust loading at GMSP.

Space transportation, satellite services, and space platforms

NASA Technical Reports Server (NTRS)

Disher, J. H.

1979-01-01

The paper takes a preview of the progressive development of vehicles for space transportation, satellite services, and orbital platforms. A low-thrust upper stage of either the ion engine or chemical type will be developed to transport large spacecraft and space platforms to and from GEO. The multimission spacecraft, space telescope, and other scientific platforms will require orbital serves going beyond that provided by the Shuttle's remote manipulator system, and plans call for extravehicular activity tools, improved remote manipulators, and a remote manned work station (the cherry picker).

A multiple pointing-mount control strategy for space platforms

NASA Technical Reports Server (NTRS)

Johnson, C. D.

1992-01-01

A new disturbance-adaptive control strategy for multiple pointing-mount space platforms is proposed and illustrated by consideration of a simplified 3-link dynamic model of a multiple pointing-mount space platform. Simulation results demonstrate the effectiveness of the new platform control strategy. The simulation results also reveal a system 'destabilization phenomena' that can occur if the set of individual platform-mounted experiment controllers are 'too responsive.'

Data Preparation 101: How to Use Query-by-Example to Get Your Research Dataset Ready for Primetime

ERIC Educational Resources Information Center

Lazarony, Paul J.; Driscoll, Donna A.

2011-01-01

Researchers are often distressed to discover that the data they wanted to use in their landmark study is not configured in a way that is usable by a Statistical Analysis Software Package (SASP). For example, the data needed may come from two or more sources and it may not be clear to the researcher how to get them combined into one analyzable…

Placental membrane aging and HMGB1 signaling associated with human parturition.

PubMed

Menon, Ramkumar; Behnia, Faranak; Polettini, Jossimara; Saade, George R; Campisi, Judith; Velarde, Michael

2016-02-01

Aging is associated with the onset of several diseases in various organ systems; however, different tissues may age differently, rendering some of them dysfunctional sooner than others. Placental membranes (fetal amniochorionic membranes) protect the fetus throughout pregnancy, but their longevity is limited to the duration of pregnancy. The age-associated dysfunction of these membranes is postulated to trigger parturition. Here, we investigated whether cellular senescence-the loss of cell division potential as a consequence of stress-is involved in placental membrane function at term. We show telomere reduction, p38 MAPK activation, increase in p21 expression, loss of lamin B1 loss, increase in SA-β-galactosidase , and senescence-associated secretory phenotype (SASP) gene expression in placental membranes after labor and delivery (term labor [TL]) compared to membranes prior to labor at term (term, not-in-labor [TNIL]). Exposing TNIL placental membranes to cigarette smoke extract, an oxidative stress inducer, also induced markers of cellular senescence similar to those in TL placental membranes. Bioinformatics analysis of differentially expressed SASP genes revealed HMGB1 signaling among the top pathways involved in labor. Further, we show that recombinant HMGB1 upregulates the expression of genes associated with parturition in myometrial cells. These data suggest that the natural physiologic aging of placental tissues is associated with cellular senescence and human parturition.

A multilevel control approach for a modular structured space platform

NASA Technical Reports Server (NTRS)

Chichester, F. D.; Borelli, M. T.

1981-01-01

A three axis mathematical representation of a modular assembled space platform consisting of interconnected discrete masses, including a deployable truss module, was derived for digital computer simulation. The platform attitude control system as developed to provide multilevel control utilizing the Gauss-Seidel second level formulation along with an extended form of linear quadratic regulator techniques. The objectives of the multilevel control are to decouple the space platform's spatial axes and to accommodate the modification of the platform's configuration for each of the decoupled axes.

Technology for the future - Long range planning for space technology development

NASA Technical Reports Server (NTRS)

Collier, Lisa D.; Breckenridge, Roger A.; Llewellyn, Charles P.

1992-01-01

NASA's Office of Aeronautics and Space Technology (OAST) has begun the definition of an Integrated Technology Plan for the civilian space program which guides long-term technology development for space platforms, in light of continuing marker research and other planning data. OAST has conferred particular responsibility for future candidate space mission evaluations and platform performance requirement projections to NASA-Langley. An implementation plan is devised which is amenable to periodic space-platform technology updates.

Regional convergence platforms in Europe—Innovation for space through technology partnerships

NASA Astrophysics Data System (ADS)

Bütfering, Peter

2010-05-01

Upcoming European and national space exploration programs and projects require new capabilities and scientific-technological solutions, and therefore external contributions to innovation. On the other hand European core (industrial) regions are searching of partners for innovation to strengthen their regional economy. In this context the German-based company European Space Innovation AG (former Adam Alva Neil)—highly experienced in the area of convergence activities between space and other sectors—has developed the model of regional convergence platforms (named 'SpaceInnovation'). These platforms are designed to foster technology partnerships between regional companies and institutes from 'non-space' and the space sector (agencies/industry). The article reflects this regional approach and shows examples in three different directions: SpaceInnovation Saar, an benchmark convergence platform initiated by the Saarland region. SpaceInnovation Europe, an European regions network approach. European SpaceInnovation Agent, an interface approach for systematic and sustainable convergence activities.

Automated Platform Management System Scheduling

NASA Technical Reports Server (NTRS)

Hull, Larry G.

1990-01-01

The Platform Management System was established to coordinate the operation of platform systems and instruments. The management functions are split between ground and space components. Since platforms are to be out of contact with the ground more than the manned base, the on-board functions are required to be more autonomous than those of the manned base. Under this concept, automated replanning and rescheduling, including on-board real-time schedule maintenance and schedule repair, are required to effectively and efficiently meet Space Station Freedom mission goals. In a FY88 study, we developed several promising alternatives for automated platform planning and scheduling. We recommended both a specific alternative and a phased approach to automated platform resource scheduling. Our recommended alternative was based upon use of exactly the same scheduling engine in both ground and space components of the platform management system. Our phased approach recommendation was based upon evolutionary development of the platform. In the past year, we developed platform scheduler requirements and implemented a rapid prototype of a baseline platform scheduler. Presently we are rehosting this platform scheduler rapid prototype and integrating the scheduler prototype into two Goddard Space Flight Center testbeds, as the ground scheduler in the Scheduling Concepts, Architectures, and Networks Testbed and as the on-board scheduler in the Platform Management System Testbed. Using these testbeds, we will investigate rescheduling issues, evaluate operational performance and enhance the platform scheduler prototype to demonstrate our evolutionary approach to automated platform scheduling. The work described in this paper was performed prior to Space Station Freedom rephasing, transfer of platform responsibility to Code E, and other recently discussed changes. We neither speculate on these changes nor attempt to predict the impact of the final decisions. As a consequence some of our work and results may be outdated when this paper is published.

Species specific identification of spore-producing microbes using the gene sequence of small acid-soluble spore coat proteins for amplification based diagnostics

DOEpatents

McKinney, Nancy

2002-01-01

PCR (polymerase chain reaction) primers for the detection of certain Bacillus species, such as Bacillus anthracis. The primers specifically amplify only DNA found in the target species and can distinguish closely related species. Species-specific PCR primers for Bacillus anthracis, Bacillus globigii and Clostridium perfringens are disclosed. The primers are directed to unique sequences within sasp (small acid soluble protein) genes.

Defensive platform size and survivability. [Platform survivability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Canavan, Gregory H.

1988-06-01

This report discusses the survivability of space platforms, concentrating on space based kinetic energy interceptors. It evaluates the efficacy of hardening, maneuver, self-defense, and deception in extending the survivability of platforms of varying sizes to expected threats, concluding that they should be adequate in the near and mid terms.

Transportation and platforms perspective

NASA Technical Reports Server (NTRS)

Bennett, Gary L.

1992-01-01

The topics covered are presented in viewgraph form and include the following: Office of Aeronautics and Space Technology; space research and technology (R&T); space R&T mission statement; Space R&T program development; R&T strategy; Office of Space Science and Applications (OSSA) technology needs; transportation technology; and space platforms technology.

Space Based Intelligence, Surveillance, and Reconnaissance Contribution to Global Strike in 2035

DTIC Science & Technology

2012-02-15

include using high altitude air platforms and airships as a short-term solution, and small satellites with an Operationally Responsive Space (ORS) launch...irreversible threats, along with a worst case scenario. Section IV provides greater detail of the high altitude air platform, airship , and commercial space...Resultantly, the U.S. could use high altitude air platforms, airships , and cyber to complement its space systems in case of denial, degradation, or

Human Fetal Membranes at Term: Dead Tissue or Signalers of Parturition?

PubMed Central

MENON, Ramkumar

2017-01-01

Various endocrine, immune, and mechanical factors produced by feto-maternal compartments at term increase intrauterine inflammatory loads to induce labor. The role of fetal (placental) membranes (amniochorion) as providers of parturition signals has not been well investigated. Fetal membranes line the intrauterine cavity and grow with and protect the fetus. Fetal membranes exist as an entity between the mother and fetus and perform unique functions during pregnancy. Membranes undergo a telomere-dependent p38 MAPK-induced senescence and demonstrate a decline in functional and mechanical abilities at term, showing signs of aging. Fetal membrane senescence is also allied with completion of fetal maturation at term as the fetus readies for delivery, which may also indicate the end of independent life and longevity of fetal membranes as their functional role concludes. Fetal membrane senescence is accelerated at term because of oxidative stress and increased stretching. Senescent fetal membranes cells produce senescence-associated secretory phenotype (SASP-inflammation) and also release proinflammatory damage-associated molecular patterns (DAMPs), namely HMGB1 and cell-free fetal telomere fragments. In a feedback loop, SASP and DAMPs increase senescence and enhance the inflammatory load to promote labor. Membranes increase the inflammatory load to disrupt homeostatic balance to transition quiescent uterine tissues toward a labor phenotype. Therefore, along with other well-described labor-promoting signals, senescent fetal membranes may also contribute to human term parturition. PMID:27452431

Placental membrane aging and HMGB1 signaling associated with human parturition

PubMed Central

Menon, Ramkumar; Behnia, Faranak; Polettini, Jossimara; Saade, George R; Campisi, Judith; Velarde, Michael

2016-01-01

Aging is associated with the onset of several diseases in various organ systems; however, different tissues may age differently, rendering some of them dysfunctional sooner than others. Placental membranes (fetal amniochorionic membranes) protect the fetus throughout pregnancy, but their longevity is limited to the duration of pregnancy. The age-associated dysfunction of these membranes is postulated to trigger parturition. Here, we investigated whether cellular senescence—the loss of cell division potential as a consequence of stress—is involved in placental membrane function at term. We show telomere reduction, p38 MAPK activation, increase in p21 expression, loss of lamin B1 loss, increase in SA-β-galactosidase, and senescence-associated secretory phenotype (SASP) gene expression in placental membranes after labor and delivery (term labor [TL]) compared to membranes prior to labor at term (term, not-in-labor [TNIL]). Exposing TNIL placental membranes to cigarette smoke extract, an oxidative stress inducer, also induced markers of cellular senescence similar to those in TL placental membranes. Bioinformatics analysis of differentially expressed SASP genes revealed HMGB1 signaling among the top pathways involved in labor. Further, we show that recombinant HMGB1 upregulates the expression of genes associated with parturition in myometrial cells. These data suggest that the natural physiologic aging of placental tissues is associated with cellular senescence and human parturition. PMID:26851389

Human fetal membranes at term: Dead tissue or signalers of parturition?

PubMed

Menon, Ramkumar

2016-08-01

Various endocrine, immune, and mechanical factors produced by feto-maternal compartments at term increase intrauterine inflammatory loads to induce labor. The role of fetal (placental) membranes (amniochorion) as providers of parturition signals has not been well investigated. Fetal membranes line the intrauterine cavity and grow with and protect the fetus. Fetal membranes exist as an entity between the mother and fetus and perform unique functions during pregnancy. Membranes undergo a telomere-dependent p38 MAPK-induced senescence and demonstrate a decline in functional and mechanical abilities at term, showing signs of aging. Fetal membrane senescence is also allied with completion of fetal maturation at term as the fetus readies for delivery, which may also indicate the end of independent life and longevity of fetal membranes as their functional role concludes. Fetal membrane senescence is accelerated at term because of oxidative stress and increased stretching. Senescent fetal membranes cells produce senescence-associated secretory phenotype (SASP-inflammation) and also release proinflammatory damage-associated molecular patterns (DAMPs), namely HMGB1 and cell-free fetal telomere fragments. In a feedback loop, SASP and DAMPs increase senescence and enhance the inflammatory load to promote labor. Membranes increase the inflammatory load to disrupt homeostatic balance to transition quiescent uterine tissues toward a labor phenotype. Therefore, along with other well-described labor-promoting signals, senescent fetal membranes may also contribute to human term parturition. Copyright © 2016 Elsevier Ltd. All rights reserved.

The 1980 Large space systems technology. Volume 2: Base technology

NASA Technical Reports Server (NTRS)

Kopriver, F., III (Compiler)

1981-01-01

Technology pertinent to large antenna systems, technology related to large space platform systems, and base technology applicable to both antenna and platform systems are discussed. Design studies, structural testing results, and theoretical applications are presented with accompanying validation data. A total systems approach including controls, platforms, and antennas is presented as a cohesive, programmatic plan for large space systems.

The Alpha-Helix Concept: Innovative utilization of the Space Station Program. A report to the National Aeronautical and Space Administration requesting establishment of a Sensory Physiology Laboratory on the Space Station

NASA Technical Reports Server (NTRS)

Bandurski, R. S.; Singh, N.

1983-01-01

A major laboratory dedicated to biological-medical research is proposed for the Space Platform. The laboratory would focus on sensor physiology and biochemistry since sensory physiology represents the first impact of the new space environment on living organisms. Microgravity and the high radiation environment of space would be used to help solve the problems of prolonged sojourns in space but, more importantly, to help solve terrestrial problems of human health and agricultural productivity. The emphasis would be on experimental use of microorganisms and small plants and small animals to minimize the space and time required to use the Space Platform for maximum human betterment. The Alpha Helix Concept, that is, the use of the Space Platform to bring experimental biomedicine to a new and extreme frontier is introduced so as to better understand the worldly environment. Staffing and instrumenting the Space Platform biomedical laboratory in a manner patterned after successful terrestrial sensory physiology laboratories is also proposed.

The Alpha-Helix Concept: Innovative utilization of the Space Station Program. A report to the National Aeronautical and Space Administration requesting establishment of a Sensory Physiology Laboratory on the Space Station

NASA Astrophysics Data System (ADS)

Bandurski, R. S.; Singh, N.

1983-10-01

A major laboratory dedicated to biological-medical research is proposed for the Space Platform. The laboratory would focus on sensor physiology and biochemistry since sensory physiology represents the first impact of the new space environment on living organisms. Microgravity and the high radiation environment of space would be used to help solve the problems of prolonged sojourns in space but, more importantly, to help solve terrestrial problems of human health and agricultural productivity. The emphasis would be on experimental use of microorganisms and small plants and small animals to minimize the space and time required to use the Space Platform for maximum human betterment. The Alpha Helix Concept, that is, the use of the Space Platform to bring experimental biomedicine to a new and extreme frontier is introduced so as to better understand the worldly environment. Staffing and instrumenting the Space Platform biomedical laboratory in a manner patterned after successful terrestrial sensory physiology laboratories is also proposed.

A new European small platform: Proteus and prospected optical application missions

NASA Astrophysics Data System (ADS)

Dubois, J.-B.; Paoli, F.

2018-04-01

Progress in technology in recent years and new industrial approaches now make it possible to design valuable optical missions using a small-class satellite, like the PROTEUS multi mission platform. Some future space optical missions using existing or planned instruments, combined with the PROTEUS platform, have been assessed by AEROSPATIALE / SPACE and DEFENSE and/or the CNES (French National Space Agency).

VAB Platform K(2) Lift & Install into Highbay 3

NASA Image and Video Library

2016-03-07

Work is underway to secure the second half of the K-level work platforms for NASA’s Space Launch System (SLS) rocket in High Bay 3 inside the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida. The platform is being secured into position on tower E, about 86 feet above the floor. The K work platforms will provide access to NASA's Space Launch System (SLS) core stage and solid rocket boosters during processing and stacking operations on the mobile launcher. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to High Bay 3 to support processing of the SLS and Orion spacecraft. A total of 10 levels of new platforms, 20 platform halves altogether, will surround the SLS rocket and Orion spacecraft.

LSST system analysis and integration task for an advanced science and application space platform

NASA Technical Reports Server (NTRS)

1980-01-01

To support the development of an advanced science and application space platform (ASASP) requirements of a representative set of payloads requiring large separation distances selected from the Science and Applications Space Platform data base. These payloads were a 100 meter diameter atmospheric gravity wave antenna, a 100 meter by 100 meter particle beam injection experiment, a 2 meter diameter, 18 meter long astrometric telescope, and a 15 meter diameter, 35 meter long large ambient deployable IR telescope. A low earth orbit at 500 km altitude and 56 deg inclination was selected as being the best compromise for meeting payload requirements. Platform subsystems were defined which would support the payload requirements and a physical platform concept was developed. Structural system requirements which included utilities accommodation, interface requirements, and platform strength and stiffness requirements were developed. An attitude control system concept was also described. The resultant ASASP concept was analyzed and technological developments deemed necessary in the area of large space systems were recommended.

Evolution of a Reconfigurable Processing Platform for a Next Generation Space Software Defined Radio

NASA Technical Reports Server (NTRS)

Kacpura, Thomas J.; Downey, Joseph A.; Anderson, Keffery R.; Baldwin, Keith

2014-01-01

The National Aeronautics and Space Administration (NASA)Harris Ka-Band Software Defined Radio (SDR) is the first, fully reprogrammable space-qualified SDR operating in the Ka-Band frequency range. Providing exceptionally higher data communication rates than previously possible, this SDR offers in-orbit reconfiguration, multi-waveform operation, and fast deployment due to its highly modular hardware and software architecture. Currently in operation on the International Space Station (ISS), this new paradigm of reconfigurable technology is enabling experimenters to investigate navigation and networking in the space environment.The modular SDR and the NASA developed Space Telecommunications Radio System (STRS) architecture standard are the basis for Harris reusable, digital signal processing space platform trademarked as AppSTAR. As a result, two new space radio products are a synthetic aperture radar payload and an Automatic Detection Surveillance Broadcast (ADS-B) receiver. In addition, Harris is currently developing many new products similar to the Ka-Band software defined radio for other applications. For NASAs next generation flight Ka-Band radio development, leveraging these advancements could lead to a more robust and more capable software defined radio.The space environment has special considerations different from terrestrial applications that must be considered for any system operated in space. Each space mission has unique requirements that can make these systems unique. These unique requirements can make products that are expensive and limited in reuse. Space systems put a premium on size, weight and power. A key trade is the amount of reconfigurability in a space system. The more reconfigurable the hardware platform, the easier it is to adapt to the platform to the next mission, and this reduces the amount of non-recurring engineering costs. However, the more reconfigurable platforms often use more spacecraft resources. Software has similar considerations to hardware. Having an architecture standard promotes reuse of software and firmware. Space platforms have limited processor capability, which makes the trade on the amount of amount of flexibility paramount.

Second interim briefing (D3). Evolutionary Science and Applications Space Platform. Characterization of concepts, tasks A and B

NASA Technical Reports Server (NTRS)

1981-01-01

The objectives were to define, evaluate, and select concepts for evolving a space station in conjunction with the Space Platform for NASA science, Applications, Technology and DOD; and a permanently manned presence in space early, with a maximum of existing technology.

Platform options for the Space Station program

NASA Technical Reports Server (NTRS)

Mangano, M. J.; Rowley, R. W.

1986-01-01

Platforms for polar and 28.5 deg orbits were studied to determine the platform requirements and characteristics necessary to support the science objectives. Large platforms supporting the Earth-Observing System (EOS) were initially studied. Co-orbiting platforms were derived from these designs. Because cost estimates indicated that the large platform approach was likely to be too expensive, require several launches, and generally be excessively complex, studies of small platforms were undertaken. Results of these studies show the small platform approach to be technically feasible at lower overall cost. All designs maximized hardware inheritance from the Space Station program to reduce costs. Science objectives as defined at the time of these studies are largely achievable.

The Importance of Conducting Life Sciences Experiments on the Deep Space Gateway Platform

NASA Astrophysics Data System (ADS)

Bhattacharya, S.

2018-02-01

Life science research on the Deep Space Gateway platform is an important precursor for long term human exploration of deep space. Ideas for utilizing flight hardware and well characterized model organisms will be discussed.

Front view of the Orbiter Discovery from an elevated platform ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Front view of the Orbiter Discovery from an elevated platform in the Vehicle Assembly Building at NASA's Kennedy Space Center. - Space Transportation System, Orbiter Discovery (OV-103), Lyndon B. Johnson Space Center, 2101 NASA Parkway, Houston, Harris County, TX

jsc2018m000314_Spinning_Science_Multi-use_Variable-g_Platform_Arrives_at_the_Space_Station-MP4

NASA Image and Video Library

2018-05-09

Spinning Science: Multi-use Variable-g Platform Arrives at the Space Station --- The Multi-use Variable-gravity Platform (MVP) Validation mission will install and test the MVP, a new hardware platform developed and owned by Techshot Inc., on the International Space Station (ISS). Though the MVP is designed for research with many different kinds of organisms and cell types, this validation mission will focus on Drosophila melanogaster, more commonly known as the fruit fly. This platform will be especially important for fruit fly research, as it will allow researchers to study larger sample sizes of Drosophila melanogaster than in other previous hardware utilizing centrifuges and it will be able to support fly colonies for multiple generations.

Effects of curcumin plus Soy oligosaccharides on intestinal flora of rats with ulcerative colitis.

PubMed

Huang, G; Ye, L; Du, G; Huang, Y; Wu, Y; Ge, S; Yang, Z; Zhu, G

2017-08-15

To explore the therapeutic effect of curcumin (Cur) and soybean oligosaccharides (SBOS) on ulcerative colitis (UC) through testing the intestinal flora and ulcerative colitis (UC). 80 male SD rats were selected divided into four groups with 20 rats in each group: normal group, sulfasalazine (SASP) group, model group and group of curcumin plus soy oligosaccharide. All animals were treated for 4 weeks. In the fifth week rats were decapitated. Macroscopic damage scores of colonic mucosa were calculated. A 4mL blood sample was taken to detect the contents of serum tumor necrosis factor -α (TNF-α) and interleukin 8 (IL-8) by the double antibody sandwich ABC-ELISA method (enzyme-linked immunosorbent assay). Colonic tissues with the most obvious lesions were obtained using a surgical scissor. A routine hematoxylin-eosin (HE) staining method was used to stain pathological specimens and images of staining results were obtained. Histological injury scores of colonic mucosa were calculated. Ulcerative colitis model rats had the highest macroscopic damage scores and histological injury scores of colonic mucosa. After treatment the contents of TNF-α and IL-8 decreased significantly in the group of curcumin plus soy oligosaccharide compared with the model group with statistical significance (P <0.01) while the contents were close to those in the SASP group. There was no statistical significance (P> 0.05). The treatment could decrease TNF-α and IL- 8 expression and reduce colonic mucosa inflammation and tissue damage.

Floor Plans Rolling Platform, Tech Systems Platform, and Load ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Floor Plans - Rolling Platform, Tech Systems Platform, and Load Platform Plans - Marshall Space Flight Center, F-1 Engine Static Test Stand, On Route 565 between Huntsville and Decatur, Huntsville, Madison County, AL

DEEP SPACE: High Resolution VR Platform for Multi-user Interactive Narratives

NASA Astrophysics Data System (ADS)

Kuka, Daniela; Elias, Oliver; Martins, Ronald; Lindinger, Christopher; Pramböck, Andreas; Jalsovec, Andreas; Maresch, Pascal; Hörtner, Horst; Brandl, Peter

DEEP SPACE is a large-scale platform for interactive, stereoscopic and high resolution content. The spatial and the system design of DEEP SPACE are facing constraints of CAVETM-like systems in respect to multi-user interactive storytelling. To be used as research platform and as public exhibition space for many people, DEEP SPACE is capable to process interactive, stereoscopic applications on two projection walls with a size of 16 by 9 meters and a resolution of four times 1080p (4K) each. The processed applications are ranging from Virtual Reality (VR)-environments to 3D-movies to computationally intensive 2D-productions. In this paper, we are describing DEEP SPACE as an experimental VR platform for multi-user interactive storytelling. We are focusing on the system design relevant for the platform, including the integration of the Apple iPod Touch technology as VR control, and a special case study that is demonstrating the research efforts in the field of multi-user interactive storytelling. The described case study, entitled "Papyrate's Island", provides a prototypical scenario of how physical drawings may impact on digital narratives. In this special case, DEEP SPACE helps us to explore the hypothesis that drawing, a primordial human creative skill, gives us access to entirely new creative possibilities in the domain of interactive storytelling.

Platform C Installation

NASA Image and Video Library

2016-10-19

A heavy-lift crane lowers the first half of the C-level work platforms, C south, for NASA’s Space Launch System (SLS) rocket, for installation on the south side of High Bay 3 in the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. In view below Platform C are several of the previously installed platforms. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence.

PubMed

Wiley, Christopher D; Flynn, James M; Morrissey, Christapher; Lebofsky, Ronald; Shuga, Joe; Dong, Xiao; Unger, Marc A; Vijg, Jan; Melov, Simon; Campisi, Judith

2017-10-01

Senescent cells play important roles in both physiological and pathological processes, including cancer and aging. In all cases, however, senescent cells comprise only a small fraction of tissues. Senescent phenotypes have been studied largely in relatively homogeneous populations of cultured cells. In vivo, senescent cells are generally identified by a small number of markers, but whether and how these markers vary among individual cells is unknown. We therefore utilized a combination of single-cell isolation and a nanofluidic PCR platform to determine the contributions of individual cells to the overall gene expression profile of senescent human fibroblast populations. Individual senescent cells were surprisingly heterogeneous in their gene expression signatures. This cell-to-cell variability resulted in a loss of correlation among the expression of several senescence-associated genes. Many genes encoding senescence-associated secretory phenotype (SASP) factors, a major contributor to the effects of senescent cells in vivo, showed marked variability with a subset of highly induced genes accounting for the increases observed at the population level. Inflammatory genes in clustered genomic loci showed a greater correlation with senescence compared to nonclustered loci, suggesting that these genes are coregulated by genomic location. Together, these data offer new insights into how genes are regulated in senescent cells and suggest that single markers are inadequate to identify senescent cells in vivo. © 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

Space construction system analysis. Part 2: Platform definition

NASA Technical Reports Server (NTRS)

Hart, R. J.; Myers, H. L.; Abramson, R. D.; Dejong, P. N.; Donavan, R. D.; Greenberg, H. S.; Indrikis, J.; Jandrasi, J. S.; Manoff, M.; Mcbaine, C. K.

1980-01-01

The top level system requirements are summarized and the accompanying conceptual design for an engineering and technology verification platform (ETVP) system is presented. An encompassing statement of the system objectives which drive the system requirements is presented and the major mission and subsystem requirements are described with emphasis on the advanced communications technology mission payload. The platform design is defined and used as a reference configuration for an end to space construction analyses. The preferred construction methods and processes, the important interactions between the platform design and the construction system design and operation, and the technology development efforts required to support the design and space construction of the ETVP are outlined.

Floor Plans Engine Removal Platform, Hold Down Arm Platform, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Floor Plans - Engine Removal Platform, Hold Down Arm Platform, Hydraulic Equipment Platforms, Isometric Cutaway of Engine Removal Platform, Isometric Cutaway of Hold Down Arm Platform, Isometric Cutaway of Hydraulic Platforms and Engine Support System Access - Marshall Space Flight Center, Saturn V S-IC Static Test Facility, West Test Area, Huntsville, Madison County, AL

Platform C Installation

NASA Image and Video Library

2016-10-19

Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, construction workers assist with the installation of the first half of the C-level work platforms, C south, for NASA’s Space Launch System (SLS) rocket. The large bolts that hold the platform in place on the south wall are being secured. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Platform C Installation

NASA Image and Video Library

2016-10-19

Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, the first half of the C-level work platforms, C south, for NASA’s Space Launch System (SLS) rocket, has been installed on the south side of the high bay. In view below are several levels of previously installed platforms. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

View from second floor platform looking up at subsequent platforms. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View from second floor platform looking up at subsequent platforms. Note the Shuttle assembly outlined by the platform edges. - Marshall Space Flight Center, Saturn V Dynamic Test Facility, East Test Area, Huntsville, Madison County, AL

Strawman payload data for science and applications space platforms

NASA Technical Reports Server (NTRS)

1980-01-01

The need for a free flying science and applications space platform to host compatible long duration experiment groupings in Earth orbit is discussed. Experiment level information on strawman payload models is presented which serves to identify and quantify the requirements for the space platform system. A description data base on the strawman payload model is presented along with experiment level and group level summaries. Payloads identified in the strawman model include the disciplines of resources observations and environmental observations.

Space Station as a Long Duration Exposure Facility

NASA Technical Reports Server (NTRS)

Folley, Adrienne; Scheib, Jim

1995-01-01

There is need for a space platform for experiments investigating long duration exposure to space. This platform should be maintainable in the event of a malfunction, and experiments should be easily recoverable for analysis on Earth. The International Space Station provides such a platform. The current Space Station configuration has six external experiment attachment sites, providing utilities and data support distributed along the external truss. There are also other sites that could potentially support long duration exposure experiments. This paper describes the resources provided to payloads at these sites, and cites examples of integration of proposed long duration exposure experiments on these sites. The environments to which external attached payloads will be exposed are summarized.

Platform C North Installation

NASA Image and Video Library

2016-11-10

A heavy-lift crane lifts the second half of the C-level work platforms, C north, for NASA’s Space Launch System (SLS) rocket, high up from the transfer aisle of the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. The C platform will be moved into High Bay 3 for installation on the north side of High Bay 3. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. In view below Platform C are several of the previously installed platforms. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Geostationary platform systems concepts definition study. Volume 2: Technical, book 3

NASA Technical Reports Server (NTRS)

1980-01-01

The supporting research and technology, and space demonstrations required to support the 1990s operational geostationary platforms are identified. Also the requirements on and interfaces with the Space Transportation System hardware elements supporting the geostationary platform program, including the shuttle, orbital transfer vehicles, teleoperator, etc., are investigated to provide integrated support requirements. Finally, a preliminary evaluation of the practicability and capabilities of an experimental platform from the standpoint of technology, schedule, and cost is given.

Platform C North Installation

NASA Image and Video Library

2016-11-10

A heavy-lift crane lowers the second half of the C-level work platforms, C north, for NASA’s Space Launch System (SLS) rocket, into High Bay 3 of the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. The C platform will be installed on the north side of High Bay 3. In view below are several of the previously installed levels of platforms. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

KENNEDY SPACE CENTER, FLA. - This bird's-eye view of a high bay in the Orbiter Processing Facility (OPF) shows Space Shuttle Atlantis surrounded by the standard platforms and equipment required to process a Space Shuttle orbiter for flight. The high bay is 197 feet (60 meters) long, 150 feet (46 meters) wide, 95 feet (29 meters) high, and encompasses a 29,000-square-foot (2,694-meter) area. Platforms, a main access bridge, and two rolling bridges with trucks provide access to various parts of the orbiter. The next mission scheduled for Atlantis is STS-114, a utilization and logistics flight to the International Space Station.

NASA Image and Video Library

2003-09-03

KENNEDY SPACE CENTER, FLA. - This bird's-eye view of a high bay in the Orbiter Processing Facility (OPF) shows Space Shuttle Atlantis surrounded by the standard platforms and equipment required to process a Space Shuttle orbiter for flight. The high bay is 197 feet (60 meters) long, 150 feet (46 meters) wide, 95 feet (29 meters) high, and encompasses a 29,000-square-foot (2,694-meter) area. Platforms, a main access bridge, and two rolling bridges with trucks provide access to various parts of the orbiter. The next mission scheduled for Atlantis is STS-114, a utilization and logistics flight to the International Space Station.

Earth resources instrumentation for the Space Station Polar Platform

NASA Technical Reports Server (NTRS)

Donohoe, Martin J.; Vane, Deborah

1986-01-01

The spacecraft and payloads of the Space Station Polar Platform program are described in a brief overview. Present plans call for one platform in a descending morning-equator-crossing orbit at 824 km and two or three platforms in ascending afternoon-crossing orbits at 542-824 km. The components of the NASA Earth Observing System (EOS) and NOAA payloads are listed in tables and briefly characterized, and data-distribution requirements and the mission development schedule are discussed. A drawing of the platform, a graph showing the spectral coverage of the EOS instruments, and a glossary of acronyms are provided.

Control system design for the large space systems technology reference platform

NASA Technical Reports Server (NTRS)

Edmunds, R. S.

1982-01-01

Structural models and classical frequency domain control system designs were developed for the large space systems technology (LSST) reference platform which consists of a central bus structure, solar panels, and platform arms on which a variety of experiments may be mounted. It is shown that operation of multiple independently articulated payloads on a single platform presents major problems when subarc second pointing stability is required. Experiment compatibility will be an important operational consideration for systems of this type.

Platform C Installation

NASA Image and Video Library

2016-10-19

A heavy-lift crane lifts the first half of the C-level work platforms, C south, for NASA’s Space Launch System (SLS) rocket, high up from the transfer aisle floor of the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida. The C platform will be installed on the south side of High Bay 3. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Platform C North Installation

NASA Image and Video Library

2016-11-10

A heavy-lift crane lifts the second half of the C-level work platforms, C north, for NASA’s Space Launch System (SLS) rocket, high up from the transfer aisle floor of the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida. The C platform will be installed on the north side of High Bay 3. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Platform C Installation

NASA Image and Video Library

2016-10-19

A heavy-lift crane lifts the first half of the C-level work platforms, C south, for NASA’s Space Launch System (SLS) rocket, high up from the transfer aisle floor of the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida. The C platform will be moved into High Bay 3 for installation on the south wall. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Platform C Installation

NASA Image and Video Library

2016-10-19

Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, a construction worker assist with the installation of the first half of the C-level work platforms, C south, for NASA’s Space Launch System (SLS) rocket. The large bolts that hold the platform in place on the south wall are being secured. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Platform C North Installation

NASA Image and Video Library

2016-11-10

A heavy-lift crane lifts the second half of the C-level work platforms, C north, for NASA’s Space Launch System (SLS) rocket, up from the transfer aisle floor of the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida. The C platform will be installed on the north side of High Bay 3. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Platform C North Installation

NASA Image and Video Library

2016-11-10

A heavy-lift crane lifts the second half of the C-level work platforms, C north, for NASA’s Space Launch System (SLS) rocket, high up from the transfer aisle floor of the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida. The C platform will be moved into High Bay 3 for installation on the north wall. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Blade platform seal for ceramic/metal rotor assembly

DOEpatents

Wertz, John L.

1982-01-01

A combination ceramic and metal turbine rotor for use in high temperature gas turbine engines includes a metal rotor disc having a rim with a plurality of circumferentially spaced blade root retention slots therein to receive a plurality of ceramic blades, each including side platform segments thereon and a dovetail configured root slidably received in one of the slots. Adjacent ones of the platform segments including edge portions thereon closely spaced when the blades are assembled to form expansion gaps in an annular flow surface for gas passage through the blades and wherein the assembly further includes a plurality of unitary seal members on the rotor connected to its rim and each including a plurality of spaced, axially extending, flexible fingers that underlie and conform to the edge portions of the platform segments and which are operative at turbine operating temperatures and speeds to distribute loading on the platform segments as the fingers are seated against the underside of the blade platforms to seal the gaps without undesirably stressing thin web ceramic sections of the platform.

Reconfigurable, Intelligently-Adaptive, Communication System, an SDR Platform

NASA Technical Reports Server (NTRS)

Roche, Rigoberto

2016-01-01

The Space Telecommunications Radio System (STRS) provides a common, consistent framework to abstract the application software from the radio platform hardware. STRS aims to reduce the cost and risk of using complex, configurable and reprogrammable radio systems across NASA missions. The Glenn Research Center (GRC) team made a software-defined radio (SDR) platform STRS compliant by adding an STRS operating environment and a field programmable gate array (FPGA) wrapper, capable of implementing each of the platforms interfaces, as well as a test waveform to exercise those interfaces. This effort serves to provide a framework toward waveform development on an STRS compliant platform to support future space communication systems for advanced exploration missions. Validated STRS compliant applications provided tested code with extensive documentation to potentially reduce risk, cost and efforts in development of space-deployable SDRs. This paper discusses the advantages of STRS, the integration of STRS onto a Reconfigurable, Intelligently-Adaptive, Communication System (RIACS) SDR platform, the sample waveform, and wrapper development efforts. The paper emphasizes the infusion of the STRS Architecture onto the RIACS platform for potential use in next generation SDRs for advance exploration missions.

The Wake Shield Facility: A space experiment platform

NASA Technical Reports Server (NTRS)

Allen, Joseph P.

1991-01-01

Information is given in viewgraph form on Wakeshield, a space experiment platform. The Wake Shield Facility (WSF) flight program objectives, product applications, commercial development approach, and cooperative experiments are listed. The program objectives are to produce new industry-driven electronic, magnetic, and superconducting thin-film materials and devices both in terrestrial laboratories and in space; utilize the ultra-vacuum of space for thin film epitaxial growth and materials processing; and develop commercial space hardware for research and development and enhanced access to space.

Thin film microelectronics materials production in the vacuum of space

NASA Astrophysics Data System (ADS)

Ignatiev, A.; Sterling, M.; Horton, C.; Freundlich, A.; Pei, S.; Hill, R.

1997-01-01

The international Space Station era will open up a new dimension in the use of one of the unique attributes of space, vacuum, for the production of advanced semiconductor materials and devices for microelectronics applications. Ultra-vacuum is required for the fabrication in thin film form of high quality semiconductors. This can be accomplished behind a free flying platform similar to the current Wake Shield Facility which is specifically designed to support in-space production. The platform will require apparatus for thin film growth, a robotics interface to allow for the change out of raw materials and the harvesting of finished product, and a servicing plant incorporating Space Station that will support long-term utilization of the platform.

Space environmental effects on materials

NASA Technical Reports Server (NTRS)

Schwinghmaer, R. J.

1980-01-01

The design of long life platforms and structures for space is discussed in terms of the space environmental effects on the materials used. Vacuum, ultraviolet radiation, and charged particle radiation are among the factors considered. Research oriented toward the acquisition of long term environmental effects data needed to support the design and development of large low Earth orbit and geosynchronous Earth orbit space platforms and systems is described.

Technical issues in the conduct of large space platform experiments in plasma physics and geoplasma sciences

NASA Technical Reports Server (NTRS)

Szuszczewicz, Edward P.

1986-01-01

Large, permanently-manned space platforms can provide exciting opportunities for discoveries in basic plasma and geoplasma sciences. The potential for these discoveries will depend very critically on the properties of the platform, its subsystems, and their abilities to fulfill a spectrum of scientific requirements. With this in mind, the planning of space station research initiatives and the development of attendant platform engineering should allow for the identification of critical science and technology issues that must be clarified far in advance of space station program implementation. An attempt is made to contribute to that process, with a perspective that looks to the development of the space station as a permanently-manned Spaceborne Ionospheric Weather Station. The development of this concept requires a synergism of science and technology which leads to several critical design issues. To explore the identification of these issues, the development of the concept of an Ionospheric Weather Station will necessarily touch upon a number of diverse areas. These areas are discussed.

Chromatography process development in the quality by design paradigm I: Establishing a high-throughput process development platform as a tool for estimating "characterization space" for an ion exchange chromatography step.

PubMed

Bhambure, R; Rathore, A S

2013-01-01

This article describes the development of a high-throughput process development (HTPD) platform for developing chromatography steps. An assessment of the platform as a tool for establishing the "characterization space" for an ion exchange chromatography step has been performed by using design of experiments. Case studies involving use of a biotech therapeutic, granulocyte colony-stimulating factor have been used to demonstrate the performance of the platform. We discuss the various challenges that arise when working at such small volumes along with the solutions that we propose to alleviate these challenges to make the HTPD data suitable for empirical modeling. Further, we have also validated the scalability of this platform by comparing the results from the HTPD platform (2 and 6 μL resin volumes) against those obtained at the traditional laboratory scale (resin volume, 0.5 mL). We find that after integration of the proposed correction factors, the HTPD platform is capable of performing the process optimization studies at 170-fold higher productivity. The platform is capable of providing semi-quantitative assessment of the effects of the various input parameters under consideration. We think that platform such as the one presented is an excellent tool for examining the "characterization space" and reducing the extensive experimentation at the traditional lab scale that is otherwise required for establishing the "design space." Thus, this platform will specifically aid in successful implementation of quality by design in biotech process development. This is especially significant in view of the constraints with respect to time and resources that the biopharma industry faces today. Copyright © 2013 American Institute of Chemical Engineers.

Vulnerability assessment of a space based weapon platform electronic system exposed to a thermonuclear weapon detonation

NASA Astrophysics Data System (ADS)

Perez, C. L.; Johnson, J. O.

Rapidly changing world events, the increased number of nations with inter-continental ballistic missile capability, and the proliferation of nuclear weapon technology will increase the number of nuclear threats facing the world today. Monitoring these nation's activities and providing an early warning and/or intercept system via reconnaissance and surveillance satellites and space based weapon platforms is a viable deterrent against a surprise nuclear attack. However, the deployment of satellite and weapon platform assets in space will subject the sensitive electronic equipment to a variety of natural and man-made radiation environments. These include Van Allen Belt protons and electrons; galactic and solar flare protons; and neutrons, gamma rays, and x-rays from intentionally detonated fission and fusion weapons. In this paper, the MASH vl.0 code system is used to estimate the dose to the critical electronics components of an idealized space based weapon platform from neutron and gamma-ray radiation emitted from a thermonuclear weapon detonation in space. Fluence and dose assessments were performed for the platform fully loaded, and in several stages representing limited engagement scenarios. The results indicate vulnerabilities to the Command, Control, and Communication bay instruments from radiation damage for a nuclear weapon detonation for certain source/platform orientations. The distance at which damage occurs will depend on the weapon yield (n,(gamma)/kiloton) and size (kilotons).

Learning to build large structures in space

NASA Technical Reports Server (NTRS)

Hagler, T.; Patterson, H. G.; Nathan, C. A.

1977-01-01

The paper examines some of the key technologies and forms of construction know-how that will have to be developed and tested for eventual application to building large structures in space. Construction of a shuttle-tended space construction/demonstration platform would comprehensively demonstrate large structure technology, develop construction capability, and furnish a construction platform for a variety of operational large structures. Completion of this platform would lead to demonstrations of the Satellite Power System (SPS) concept, including microwave transmission, fabrication of 20-m-deep beams, conductor installation, rotary joint installation, and solar blanket installation.

Platform C Installation

NASA Image and Video Library

2016-10-19

A heavy-lift crane lifts the first half of the C-level work platforms, C south, for NASA’s Space Launch System (SLS) rocket, up from the transfer aisle floor of the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida. Large Tandemloc bars have been attached to the platform to keep it level during lifting and installation. The C platform will be installed on the south side of High Bay 3. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

An Innovative 6-DOF Platform for Testing a Space Robotic System to Perform Contact Tasks in Zero-Gravity Environment

DTIC Science & Technology

2013-10-21

Platform for Testing a Space Robotic System to Perform Contact Tasks in Zero- Gravity Environment 5a. CONTRACT NUMBER FA9453-11-1-0306 5b...SUBJECT TERMS Microgravity, zero gravity , test platform, simulation, gravity offloading 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT...4  3.3  Principle of Gravity Offloading

Technology review: prototyping platforms for monitoring ambient conditions.

PubMed

Afolaranmi, Samuel Olaiya; Ramis Ferrer, Borja; Martinez Lastra, Jose Luis

2018-05-08

The monitoring of ambient conditions in indoor spaces is very essential owing to the amount of time spent indoors. Specifically, the monitoring of air quality is significant because contaminated air affects the health, comfort and productivity of occupants. This research work presents a technology review of prototyping platforms for monitoring ambient conditions in indoor spaces. It involves the research on sensors (for CO 2 , air quality and ambient conditions), IoT platforms, and novel and commercial prototyping platforms. The ultimate objective of this review is to enable the easy identification, selection and utilisation of the technologies best suited for monitoring ambient conditions in indoor spaces. Following the review, it is recommended to use metal oxide sensors, optical sensors and electrochemical sensors for IAQ monitoring (including NDIR sensors for CO 2 monitoring), Raspberry Pi for data processing, ZigBee and Wi-Fi for data communication, and ThingSpeak IoT platform for data storage, analysis and visualisation.

Role of DNA protection and repair in resistance of Bacillus subtilis spores to ultrahigh shock pressures simulating hypervelocity impacts.

PubMed

Moeller, Ralf; Horneck, Gerda; Rabbow, Elke; Reitz, Günther; Meyer, Cornelia; Hornemann, Ulrich; Stöffler, Dieter

2008-11-01

Impact-induced ejections of rocks from planetary surfaces are frequent events in the early history of the terrestrial planets and have been considered as a possible first step in the potential interplanetary transfer of microorganisms. Spores of Bacillus subtilis were used as a model system to study the effects of a simulated impact-caused ejection on rock-colonizing microorganisms using a high-explosive plane wave setup. Embedded in different types of rock material, spores were subjected to extremely high shock pressures (5 to 50 GPa) lasting for fractions of microseconds to seconds. Nearly exponential pressure response curves were obtained for spore survival and linear dependency for the induction of sporulation-defective mutants. Spores of strains defective in major small, acid-soluble spore proteins (SASP) (alpha/beta-type SASP) that largely protect the spore DNA and spores of strains deficient in nonhomologous-end-joining DNA repair were significantly more sensitive to the applied shock pressure than were wild-type spores. These results indicate that DNA may be the sensitive target of spores exposed to ultrahigh shock pressures. To assess the nature of the critical physical parameter responsible for spore inactivation by ultrahigh shock pressures, the resulting peak temperature was varied by lowering the preshock temperature, changing the rock composition and porosity, or increasing the water content of the samples. Increased peak temperatures led to increased spore inactivation and reduced mutation rates. The data suggested that besides the potential mechanical stress exerted by the shock pressure, the accompanying high peak temperatures were a critical stress parameter that spores had to cope with.

Improvement of a snow albedo parameterization in the Snow-Atmosphere-Soil Transfer model: evaluation of impacts of aerosol on seasonal snow cover

NASA Astrophysics Data System (ADS)

Zhong, Efang; Li, Qian; Sun, Shufen; Chen, Wen; Chen, Shangfeng; Nath, Debashis

2017-11-01

The presence of light-absorbing aerosols (LAA) in snow profoundly influence the surface energy balance and water budget. However, most snow-process schemes in land-surface and climate models currently do not take this into consideration. To better represent the snow process and to evaluate the impacts of LAA on snow, this study presents an improved snow albedo parameterization in the Snow-Atmosphere-Soil Transfer (SAST) model, which includes the impacts of LAA on snow. Specifically, the Snow, Ice and Aerosol Radiation (SNICAR) model is incorporated into the SAST model with an LAA mass stratigraphy scheme. The new coupled model is validated against in-situ measurements at the Swamp Angel Study Plot (SASP), Colorado, USA. Results show that the snow albedo and snow depth are better reproduced than those in the original SAST, particularly during the period of snow ablation. Furthermore, the impacts of LAA on snow are estimated in the coupled model through case comparisons of the snowpack, with or without LAA. The LAA particles directly absorb extra solar radiation, which accelerates the growth rate of the snow grain size. Meanwhile, these larger snow particles favor more radiative absorption. The average total radiative forcing of the LAA at the SASP is 47.5 W m-2. This extra radiative absorption enhances the snowmelt rate. As a result, the peak runoff time and "snow all gone" day have shifted 18 and 19.5 days earlier, respectively, which could further impose substantial impacts on the hydrologic cycle and atmospheric processes.

Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity.

PubMed

Loo, Tze Mun; Kamachi, Fumitaka; Watanabe, Yoshihiro; Yoshimoto, Shin; Kanda, Hiroaki; Arai, Yuriko; Nakajima-Takagi, Yaeko; Iwama, Atsushi; Koga, Tomoaki; Sugimoto, Yukihiko; Ozawa, Takayuki; Nakamura, Masaru; Kumagai, Miho; Watashi, Koichi; Taketo, Makoto M; Aoki, Tomohiro; Narumiya, Shuh; Oshima, Masanobu; Arita, Makoto; Hara, Eiji; Ohtani, Naoko

2017-05-01

Obesity increases the risk of cancers, including hepatocellular carcinomas (HCC). However, the precise molecular mechanisms through which obesity promotes HCC development are still unclear. Recent studies have shown that gut microbiota may influence liver diseases by transferring its metabolites and components. Here, we show that the hepatic translocation of obesity-induced lipoteichoic acid (LTA), a Gram-positive gut microbial component, promotes HCC development by creating a tumor-promoting microenvironment. LTA enhances the senescence-associated secretory phenotype (SASP) of hepatic stellate cells (HSC) collaboratively with an obesity-induced gut microbial metabolite, deoxycholic acid, to upregulate the expression of SASP factors and COX2 through Toll-like receptor 2. Interestingly, COX2-mediated prostaglandin E 2 (PGE 2 ) production suppresses the antitumor immunity through a PTGER4 receptor, thereby contributing to HCC progression. Moreover, COX2 overexpression and excess PGE 2 production were detected in HSCs in human HCCs with noncirrhotic, nonalcoholic steatohepatitis (NASH), indicating that a similar mechanism could function in humans. Significance: We showed the importance of the gut-liver axis in obesity-associated HCC. The gut microbiota-driven COX2 pathway produced the lipid mediator PGE 2 in senescent HSCs in the tumor microenvironment, which plays a pivotal role in suppressing antitumor immunity, suggesting that PGE 2 and its receptor may be novel therapeutic targets for noncirrhotic NASH-associated HCC. Cancer Discov; 7(5); 522-38. ©2017 AACR. This article is highlighted in the In This Issue feature, p. 443 . ©2017 American Association for Cancer Research.

Platform C North Arrival

NASA Image and Video Library

2016-08-30

A section of the second half of the C-level platforms, C North, for NASA’s Space Launch System (SLS) rocket, arrives at the agency’s Kennedy Space Center in Florida. The platform was offloaded from a heavy lift transport truck and secured in a staging area in the west parking lot of the Vehicle Assembly Building (VAB). The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3 to support processing of the SLS and Orion spacecraft. A total of 10 levels of new platforms, 20 platform halves altogether, will surround the SLS rocket and Orion spacecraft and provide access for testing and processing.

Floor Plans Level 15 Load Platform, Level 17 Lower ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Floor Plans - Level 15 Load Platform, Level 17 Lower Platform, Level 22 and Upper Platform, and Level 27 - Marshall Space Flight Center, Saturn V S-IC Static Test Facility, West Test Area, Huntsville, Madison County, AL

Space assembly fixtures and aids

NASA Technical Reports Server (NTRS)

Bloom, K. A.; Lillenas, A. N.

1980-01-01

Concepts and requirements for assembly fixtures and aids necessary for the assembly and maintenance of spare platforms were studied. Emphasis was placed on erectable and deployable type structures with the shuttle orbiter as the assembly base. Both single and multiple orbiter flight cases for the platform assembly were considered. Applicable space platform assembly studies were reviewed to provide a data base for establishing the assembly fixture and aids design requirements, assembly constraints, and the development of representative design concepts. Conclusions indicated that fixture requirements will vary with platform size. Larger platforms will require translation relative to the orbiter RMS working volume. The installation of platform payloads and subsystems (e.g., utility distribution) must also be considered in the specification of assembly fixtures and aids.

Platform B North Installation

NASA Image and Video Library

2016-12-16

Construction workers wearing safety harnesses and tethered lines assist with the installation of the second half of the B-level work platforms, B north, for NASA’s Space Launch System (SLS) rocket, high up in the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida. They are securing the large bolts that hold the platform securely in place on the north side of High Bay 3. The B platforms are the ninth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Platform C North Installation

NASA Image and Video Library

2016-11-10

A heavy-lift crane lifts the second half of the C-level work platforms, C north, for NASA’s Space Launch System (SLS) rocket, high up from the transfer aisle of the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. The C platform will be moved into High Bay 3 for installation on the north side of High Bay 3. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Platform B North Installation

NASA Image and Video Library

2016-12-16

A construction worker solders a section of steel during the installation of the second half of the B-level work platforms, B north, for NASA's Space Launch System (SLS) rocket, in High Bay 3 in the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. Construction workers will secure the large bolts that hold the platform in place on the north wall. The B platforms are the ninth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Structural performance of space station trusses with missing members

NASA Technical Reports Server (NTRS)

Dorsey, J. T.

1986-01-01

Structural performance of orthogonal tetrahedral and Warren-type full truss beams and platforms are compared. In addition, degradation of truss structural performance is determined for beams, platforms and a space station when individual struts are removed from the trusses. The truss beam, space station, and truss platform analytical models used in the studies are described. Stiffness degradation of the trusses due to single strut failures is determined using flexible body vibration modes. Ease of strut replacement is assessed by removing a strut and examining the truss deflection at the resulting gap due to applied forces. Finally, the reduction in truss beam strength due to a missing longeron is determined for a space station transverse boom model.

Space Station Freedom electrical power system hardware commonality with the United States Polar Platform

NASA Technical Reports Server (NTRS)

Rieker, Lorra L.; Haraburda, Francis M.

1989-01-01

The National Aeronautics and Space Administration has adopted the policy to achieve the maximum practical level of commonality for the Space Station Freedom program in order to significantly reduce life cycle costs. Commonality means using identical or similar hardware/software for meeting common sets of functionally similar requirements. Information on how the concept of commonality is being implemented with respect to electric power system hardware for the Space Station Freedom and the U.S. Polar Platform is presented. Included is a historical account of the candidate common items which have the potential to serve the same power system functions on both Freedom and the Polar Platform.

Cabana Multi-User Spaceport Tour of KSC

NASA Image and Video Library

2017-02-17

Members of the news media view the 10 levels of new work platforms in High Bay 3 inside the Vehicle Assembly Building (VAB) during a tour of NASA's Kennedy Space Center in Florida with Center Director Bob Cabana. The final platform, A north, was recently installed. The platforms will surround the Space Launch System and Orion spacecraft on the mobile launcher during processing to prepare for the first test flight. The Ground Systems Development and Operations Program is overseeing upgrades to the VAB, including installation of the new work platforms.

In-Space Internet-Based Communications for Space Science Platforms Using Commercial Satellite Networks

NASA Technical Reports Server (NTRS)

Kerczewski, Robert J.; Bhasin, Kul B.; Fabian, Theodore P.; Griner, James H.; Kachmar, Brian A.; Richard, Alan M.

1999-01-01

The continuing technological advances in satellite communications and global networking have resulted in commercial systems that now can potentially provide capabilities for communications with space-based science platforms. This reduces the need for expensive government owned communications infrastructures to support space science missions while simultaneously making available better service to the end users. An interactive, high data rate Internet type connection through commercial space communications networks would enable authorized researchers anywhere to control space-based experiments in near real time and obtain experimental results immediately. A space based communications network architecture consisting of satellite constellations connecting orbiting space science platforms to ground users can be developed to provide this service. The unresolved technical issues presented by this scenario are the subject of research at NASA's Glenn Research Center in Cleveland, Ohio. Assessment of network architectures, identification of required new or improved technologies, and investigation of data communications protocols are being performed through testbed and satellite experiments and laboratory simulations.

Integrated Power, Avionics, and Software (iPAS) Space Telecommunications Radio System (STRS) Radio User's Guide -- Advanced Exploration Systems (AES)

NASA Technical Reports Server (NTRS)

Roche, Rigoberto; Shalkhauser, Mary Jo Windmille

2017-01-01

The Integrated Power, Avionics and Software (IPAS) software defined radio (SDR) was implemented on the Reconfigurable, Intelligently-Adaptive Communication System (RAICS) platform, for radio development at NASA Johnson Space Center. Software and hardware description language (HDL) code were delivered by NASA Glenn Research Center for use in the IPAS test bed and for development of their own Space Telecommunications Radio System (STRS) waveforms on the RAICS platform. The purpose of this document is to describe how to setup and operate the IPAS STRS Radio platform with its delivered test waveform.

Reconfigurable, Intelligently-Adaptive, Communication System, an SDR Platform

NASA Technical Reports Server (NTRS)

Roche, Rigoberto J.; Shalkhauser, Mary Jo; Hickey, Joseph P.; Briones, Janette C.

2016-01-01

The Space Telecommunications Radio System (STRS) provides a common, consistent framework to abstract the application software from the radio platform hardware. STRS aims to reduce the cost and risk of using complex, configurable and reprogrammable radio systems across NASA missions. The NASA Glenn Research Center (GRC) team made a software defined radio (SDR) platform STRS compliant by adding an STRS operating environment and a field programmable gate array (FPGA) wrapper, capable of implementing each of the platforms interfaces, as well as a test waveform to exercise those interfaces. This effort serves to provide a framework toward waveform development onto an STRS compliant platform to support future space communication systems for advanced exploration missions. The use of validated STRS compliant applications provides tested code with extensive documentation to potentially reduce risk, cost and e ort in development of space-deployable SDRs. This paper discusses the advantages of STRS, the integration of STRS onto a Reconfigurable, Intelligently-Adaptive, Communication System (RIACS) SDR platform, and the test waveform and wrapper development e orts. The paper emphasizes the infusion of the STRS Architecture onto the RIACS platform for potential use in next generation flight system SDRs for advanced exploration missions.

A High-power Electric Propulsion Test Platform in Space

NASA Technical Reports Server (NTRS)

Petro, Andrew J.; Reed, Brian; Chavers, D. Greg; Sarmiento, Charles; Cenci, Susanna; Lemmons, Neil

2005-01-01

This paper will describe the results of the preliminary phase of a NASA design study for a facility to test high-power electric propulsion systems in space. The results of this design study are intended to provide a firm foundation for subsequent detailed design and development activities leading to the deployment of a valuable space facility. The NASA Exploration Systems Mission Directorate is sponsoring this design project. A team from the NASA Johnson Space Center, Glenn Research Center, the Marshall Space Flight Center and the International Space Station Program Office is conducting the project. The test facility is intended for a broad range of users including government, industry and universities. International participation is encouraged. The objectives for human and robotic exploration of space can be accomplished affordably, safely and effectively with high-power electric propulsion systems. But, as thruster power levels rise to the hundreds of kilowatts and up to megawatts, their testing will pose stringent and expensive demands on existing Earth-based vacuum facilities. These considerations and the human access to near-Earth space provided by the International Space Station (ISS) have led to a renewed interest in space testing. The ISS could provide an excellent platform for a space-based test facility with the continuous vacuum conditions of the natural space environment and no chamber walls to modify the open boundary conditions of the propulsion system exhaust. The test platform could take advantage of the continuous vacuum conditions of the natural space environment. Space testing would provide open boundary conditions without walls, micro-gravity and a realistic thermal environment. Testing on the ISS would allow for direct observation of the test unit, exhaust plume and space-plasma interactions. When necessary, intervention by on-board personnel and post-test inspection would be possible. The ISS can provide electrical power, a location for diagnostic instruments, data handling and thermal control. The platform will be designed to accommodate the side-by-side testing of multiple types of electric thrusters. It is intended to be a permanent facility in which different thrusters can be tested over time. ISS crews can provide maintenance for the platform and change out thruster test units as needed. The primary objective of this platform is to provide a test facility for electric propulsion devices of interest for future exploration missions. These thrusters are expected to operate in the range of hundreds of kilowatts and above. However, a platform with this capability could also accommodate testing of thrusters that require much lower power levels. Testing at the higher power levels would be accomplished by using power fiom storage devices on the platform, which would be gradually recharged by the ISS power generation system. This paper will summarize the results of the preliminary phase of the study with an explanation of the user requirements and the initial conceptual design. The concept for test operations will also be described. The NASA project team is defining the requirements but they will also reflect the inputs of the broader electric propulsion community including those at universities, commercial enterprises and other government laboratories. As a facility on the International Space Station, the design requirements are also intended to encompass the needs of international users. Testing of electric propulsion systems on the space station will help advance the development of systems needed for exploration and could also serve the needs of other customers. Propulsion systems being developed for commercial and military applications could be tested and certification testing of mature thrusters could be accomplished in the space environment.

A Study of Covert Communications in Space Platforms Hosting Government Payloads

DTIC Science & Technology

2015-02-01

possible adversarial actions (e.g., malicious software co- resident on the commercial host). Threats to the commercial supply chain are just one... supply chain to either create or exploit channel vulnerabilities. For government hosted payload missions, the critical payload data are encrypted...access to space by hosting government- supplied payloads on commercial space platforms. These commercially hosted payloads require stringent

Design summary of a geostationary facility utilized as a communications platform

NASA Technical Reports Server (NTRS)

Barberis, N. J.; Brown, J. V.

1986-01-01

This paper describes the technical aspects of a geostationary platform facility that makes maximum use of the planned NASA space station and its elements, mainly the orbital maneuvering vehicle (OMV) and the orbital transfer vehicles (OTV). The platform design concept is described, with emphasis on the key technologies utilized to configure the platform. Key systems aspects include a design summary with discussion of the controls, telemetry, command and ranging, power, propulsion, control electronics, thermal control subsystems, and space station interfaces. The use of the facility as a communications platform is developed to demonstrate the attractiveness of the concept. The economic benefits are discussed, as well as the concept of servicing for payload upgrade.

Platform C South Arrival

NASA Image and Video Library

2016-08-05

A heavy load transport truck from Tillett Heavy Hauling in Titusville, Florida, arrives at the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida, carrying the second section of the first half of the C-level work platforms, C South, for the agency’s Space Launch System (SLS) rocket. The platform will be offloaded in the VAB staging area in the west parking lot. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3 to support processing of the SLS and Orion spacecraft. A total of 10 levels of new platforms, 20 platform halves altogether, will surround the SLS rocket and Orion spacecraft and provide access for testing and processing.

Platform C South Arrival

NASA Image and Video Library

2016-08-04

A heavy load transport truck from Tillett Heavy Hauling in Titusville, Florida, arrives at the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida, carrying a section of the first half of the C-level work platforms, C south, for the agency’s Space Launch System (SLS) rocket. The platform will be delivered to the VAB staging area in the west parking lot. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3 to support processing of the SLS and Orion spacecraft. A total of 10 levels of new platforms, 20 platform halves altogether, will surround the SLS rocket and Orion spacecraft and provide access for testing and processing.

VAB Platform K(2) Lift & Install into Highbay 3

NASA Image and Video Library

2016-03-07

A 250-ton crane is used to lower the second half of the K-level work platforms for NASA’s Space Launch System (SLS) rocket into High Bay 3 inside the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida. The platform will be secured about 86 feet above the VAB floor, on tower E of the high bay. The K work platforms will provide access to the SLS core stage and solid rocket boosters during processing and stacking operations on the mobile launcher. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to High Bay 3 to support processing of the SLS and Orion spacecraft. A total of 10 levels of new platforms, 20 platform halves altogether, will surround the SLS rocket and Orion spacecraft.

VAB Platform K(2) Lift & Install into Highbay 3

NASA Image and Video Library

2016-03-07

A 250-ton crane is used to lift the second half of the K-level work platforms for NASA’s Space Launch System (SLS) rocket high above the transfer aisle inside the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida. The platform is being lifted up for transfer into High Bay 3 for installation. The platform will be secured about 86 feet above the VAB floor, on tower E of the high bay. The K work platforms will provide access to the SLS core stage and solid rocket boosters during processing and stacking operations on the mobile launcher. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to High Bay 3 to support processing of the SLS and Orion spacecraft. A total of 10 levels of new platforms, 20 platform halves altogether, will surround the SLS rocket and Orion spacecraft.

Platform C South Arrival

NASA Image and Video Library

2016-08-05

The second section of the first half of the C-level work platforms, C South, for NASA’s Space Launch System (SLS) rocket was offloaded from a heavy transport truck in a staging area on the west side of the Vehicle Assembly Building (VAB) at the agency’s Kennedy Space Center in Florida. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3 to support processing of the SLS and Orion spacecraft. A total of 10 levels of new platforms, 20 platform halves altogether, will surround the SLS rocket and Orion spacecraft and provide access for testing and processing.

Erectable space platform for space sciences and applications

NASA Technical Reports Server (NTRS)

1979-01-01

The specific objectives of the study were to: (1) identify a viable conceptual design for the service module/platform; (2) assess the technology issues that must be faced in planning development; and (3) prepare an initial plan for bringing critical technologies up to acceptable levels.

Evolutionary space platform concept study. Volume 3: Programmatics for manned space platform concepts

NASA Technical Reports Server (NTRS)

1982-01-01

The programmatic data for the reference concept of the Manned Space Platform is presented. Details regarding work breakdown structure (WBS) and dictionary, the facilities and equipment required to produce the modules, the project schedule and logic diagram, a preliminary assessment of environmental impacts and details regarding the estimated costs for the reference concept are included. The proposed WBS which was developed to provide summary and system level segregation of the nonrecurring and recurring portions of the Manned Space Platform project is also included. The accompanying dictionary outlines the function and activities contained within each WBS element. The facility and equipment required to produce the various modules is discussed. Generally, required equipment is within the existing state of the art although the size of some of the items to be manufactured is a consideration. A preliminary manufacturing flow was also provided. The project schedules presented consist of the Master Project Summary Schedule, the Master Project Phasing Chart and the Logic Network.

Large space structures controls research and development at Marshall Space Flight Center: Status and future plans

NASA Technical Reports Server (NTRS)

Buchanan, H. J.

1983-01-01

Work performed in Large Space Structures Controls research and development program at Marshall Space Flight Center is described. Studies to develop a multilevel control approach which supports a modular or building block approach to the buildup of space platforms are discussed. A concept has been developed and tested in three-axis computer simulation utilizing a five-body model of a basic space platform module. Analytical efforts have continued to focus on extension of the basic theory and subsequent application. Consideration is also given to specifications to evaluate several algorithms for controlling the shape of Large Space Structures.

Space Station Freedom electrical power system hardware commonality with the United States Polar Platform

NASA Technical Reports Server (NTRS)

Rieker, Lorra L.; Haraburda, Francis M.

1989-01-01

Information is presented on how the concept of commonality is being implemented with respect to electric power system hardware for the Space Station Freedom and the U.S. Polar Platform. Included is a historical account of the candidate common items which have the potential to serve the same power system functions on both Freedom and the Polar Platform. The Space Station program and objectives are described, focusing on the test and development responsibilities. The program definition and preliminary design phase and the design and development phase are discussed. The goal of this work is to reduce the program cost.

KSC-2009-1567

NASA Image and Video Library

2009-02-12

CAPE CANAVERAL, Fla. – An aerial view of a mobile launcher platform that is parked in the Launch Complex 39 Area at NASA's Kennedy Space Center in Florida. The platform, which is a moveable base for the launch of space shuttle, is a two-story steel structure 25 feet high, 160 feet long and 135 feet wide. It is constructed of welded steel up to 6 inches thick. The platform rests on six 22-foot-tall pedestals. Photo credit: NASA/Kim Shiflett

KSC-2009-1566

NASA Image and Video Library

2009-02-12

CAPE CANAVERAL, Fla. – An aerial view of a mobile launcher platform that is parked in the Launch Complex 39 Area at NASA's Kennedy Space Center in Florida. The platform, which is a moveable base for the launch of space shuttle, is a two-story steel structure 25 feet high, 160 feet long and 135 feet wide. It is constructed of welded steel up to 6 inches thick. The platform rests on six 22-foot-tall pedestals. Photo credit: NASA/Kim Shiflett

KSC-2009-1568

NASA Image and Video Library

2009-02-12

CAPE CANAVERAL, Fla. – An aerial view of a mobile launcher platform that is parked in the Launch Complex 39 Area at NASA's Kennedy Space Center in Florida. The platform, which is a moveable base for the launch of space shuttle, is a two-story steel structure 25 feet high, 160 feet long and 135 feet wide. It is constructed of welded steel up to 6 inches thick. The platform rests on six 22-foot-tall pedestals. Photo credit: NASA/Kim Shiflett

Floor Plans Fuel Tank Support, Fuel Platform, and LOX ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Floor Plans - Fuel Tank Support, Fuel Platform, and LOX Platform Plans - Marshall Space Flight Center, F-1 Engine Static Test Stand, On Route 565 between Huntsville and Decatur, Huntsville, Madison County, AL

Space flight nutrition research: platforms and analogs

NASA Technical Reports Server (NTRS)

Smith, Scott M.; Uchakin, Peter N.; Tobin, Brian W.

2002-01-01

Conducting research during actual or simulated weightlessness is a challenging endeavor, where even the simplest activities may present significant challenges. This article reviews some of the potential obstacles associated with performing research during space flight and offers brief descriptions of current and previous space research platforms and ground-based analogs, including those for human, animal, and cell-based research. This review is intended to highlight the main issues of space flight research analogs and leave the specifics for each physiologic system for the other papers in this section.

Platform C South Arrival

NASA Image and Video Library

2016-08-04

A heavy load transport truck from Tillett Heavy Hauling in Titusville, Florida, arrives at the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida, carrying a section of the first half of the C-level work platforms, C South, for the agency’s Space Launch System (SLS) rocket. The platform is being lifted and transferred onto support stands in the VAB staging area in the west parking lot. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3 to support processing of the SLS and Orion spacecraft. A total of 10 levels of new platforms, 20 platform halves altogether, will surround the SLS rocket and Orion spacecraft and provide access for testing and processing.

Design and Development of VHF Antennas for Space Borne Signal of Opportunity Receivers for Cubesat Platforms

NASA Technical Reports Server (NTRS)

Deshpande, Manohar; Piepmeier, Jeffrey

2015-01-01

Design and Development of VHF Antennas for Space Borne Signal of Opportunity Receivers for Cubesat Platforms. Space borne microwave remote sensors at VHF/UHF frequencies are important instruments to observe reflective properties of land surfaces through thick and heavy forestation on a global scale. One of the most cost effective ways of measuring land reflectivity at VHF/UHF frequencies is to use signals transmitted by existing communication satellites (operating at VHF/UHF band) as a signal of opportunity (SoOp) signal and passive receivers integrated with airborne/space borne platforms operating in the Low Earth Orbit (LEO). One of the critical components of the passive receiver is two antennas (one to receive only direct signal and other to receive only reflected signal) which need to have ideally high (>30dB) isolation. However, because of small size of host platforms and broad beam width of dipole antennas, achieving adequate isolation between two channels is a challenging problem and need to be solved for successful implementation of space borne SoOp technology for remote sensing. In this presentation a novel enabling VHF antenna technology for Cubesat platforms is presented to receive direct as well as reflected signal with needed isolation. The novel scheme also allows enhancing the gain of individual channels by factor of 2 without use of reflecting ground plane

The Case for Spacecrime: The Rise of Crime and Piracy in the Space Domain

DTIC Science & Technology

2013-06-01

resulted in generally outdated hardware with limited capabilities.21 More recent hardware platforms such as Arduino, BeagleBone, Raspberry Pi and others...www.citizensinspace.org; Arduino platform, http://www.arduino.cc; Beaglebone platform, http://www.beagleboard.org; Raspberry Pi platform, http

Organics in Space: Results from Space Exposure Platforms and Nanosatellites

NASA Technical Reports Server (NTRS)

Foing, B. H.; Ehrenfreund, P.; Salama, Farid; Contreras, Cesar Sanchez; Sciamma O'Brien, Ella; Bejaoui, Salma

2015-01-01

A series of successful laboratory astrophysics experiments performed on International Space Station(ISS) external platforms such as EXPOSE have provided insights into the evolution of organic and biological materials in space and planetary environments. The study of the reactions, destruction, and longevity of organics in the space environment is of fundamental interest. To provide an accurate outer space environment for extended durations, exposure experiments in low Earth orbit have been conducted in the last decades in order to examine the consequences of actual space conditions including combinations of solar and cosmic radiation, space vacuum, and microgravity. The OOREOS (OrganismORganic Exposure to Orbital Stresses) nanosatellite studied in situ during the 6-month primary and 1-year extended mission the photochemical processing of selected PAHs in low Earth orbit (650 km altitude); results were autonomously telemetered to Earth. We report on the methods and flight preparation of samples for space exposure platforms and results on the stability of organic thin-films. The UV-vis degradation process of thin-films was recorded over time, which revealed intriguing and counter-intuitive photolytic kinetics that will be re-investigated on the ISS in a space environment.

Discussion on Application of Space Materials and Technological Innovation in Dynamic Fashion Show

NASA Astrophysics Data System (ADS)

Huo, Meilin; Kim, Chul Soo; Zhao, Wenhan

2018-03-01

In modern dynamic fashion show, designers often use the latest ideas and technology, and spend their energy in stage effect and overall environment to make audience’s watching a fashion show like an audio-visual feast. With rapid development of China’s science and technology, it has become a design trend to strengthen the relationship between new ideas, new trends and technology in modern art. With emergence of new technology, new methods and new materials, designers for dynamic fashion show stage art can choose the materials with an increasingly large scope. Generation of new technology has also made designers constantly innovate the stage space design means, and made the stage space design innovated constantly on the original basis of experiences. The dynamic clothing display space is on design of clothing display space, layout, platform decoration style, platform models, performing colors, light arrangement, platform background, etc.

KENNEDY SPACE CENTER, FLA. - STS-114 Commander Eileen Collins and Mission Specialist Wendy Lawrence look over mission equipment in the Space Station Processing Facility. Crew members are at KSC for equipment familiarization. STS-114 is classified as Logistics Flight 1 to the International Space Station, delivering new supplies and replacing one of the orbital outpost’s Control Moment Gyroscopes (CMGs). STS-114 will also carry a Raffaello Multi-Purpose Logistics Module and the External Stowage Platform-2. The crew is slated to conduct at least three spacewalks: They will demonstrate repair techniques of the Shuttle’s Thermal Protection System, replace the failed CMG with one delivered by the Shuttle, and install the External Stowage Platform.

NASA Image and Video Library

2004-01-27

KENNEDY SPACE CENTER, FLA. - STS-114 Commander Eileen Collins and Mission Specialist Wendy Lawrence look over mission equipment in the Space Station Processing Facility. Crew members are at KSC for equipment familiarization. STS-114 is classified as Logistics Flight 1 to the International Space Station, delivering new supplies and replacing one of the orbital outpost’s Control Moment Gyroscopes (CMGs). STS-114 will also carry a Raffaello Multi-Purpose Logistics Module and the External Stowage Platform-2. The crew is slated to conduct at least three spacewalks: They will demonstrate repair techniques of the Shuttle’s Thermal Protection System, replace the failed CMG with one delivered by the Shuttle, and install the External Stowage Platform.

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialist Andrew Thomas works on equipment in the Space Station Processing Facility. He and other crew members are at KSC for equipment familiarization. STS-114 is classified as Logistics Flight 1 to the International Space Station, delivering new supplies and replacing one of the orbital outpost’s Control Moment Gyroscopes (CMGs). STS-114 will also carry a Raffaello Multi-Purpose Logistics Module and the External Stowage Platform-2. The crew is slated to conduct at least three spacewalks: They will demonstrate repair techniques of the Shuttle’s Thermal Protection System, replace the failed CMG with one delivered by the Shuttle, and install the External Stowage Platform.

NASA Image and Video Library

2004-01-27

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialist Andrew Thomas works on equipment in the Space Station Processing Facility. He and other crew members are at KSC for equipment familiarization. STS-114 is classified as Logistics Flight 1 to the International Space Station, delivering new supplies and replacing one of the orbital outpost’s Control Moment Gyroscopes (CMGs). STS-114 will also carry a Raffaello Multi-Purpose Logistics Module and the External Stowage Platform-2. The crew is slated to conduct at least three spacewalks: They will demonstrate repair techniques of the Shuttle’s Thermal Protection System, replace the failed CMG with one delivered by the Shuttle, and install the External Stowage Platform.

Single-ended counter-rotating radial turbine for space application

DOEpatents

Coomes, E.P.; Wilson, D.G.; Webb, B.J.; McCabe, S.J.

1987-05-13

A single-ended turbine with counter-rotating blades operating with sodium as the working fluid. The single-ended, counter-rotating feature of the turbine results in zero torque application to a space platform. Thus, maneuvering of the platform is not adversely affected by the turbine. 4 figs.

MISSE-X: An ISS External Platform for Space Environmental Studies in the Post-Shuttle Era

NASA Technical Reports Server (NTRS)

Thibeault, Sheila A.; Cooke, Stuart A.; Ashe, Melissa P.; Saucillo, Rudolph J.; Murphy, Douglas G.; deGroh, Kim K.; Jaworske, Donald A.; Nguyen, Quang-Viet

2011-01-01

Materials International Space Station Experiment-X (MISSE-X) is a proposed International Space Station (ISS) external platform for space environmental studies designed to advance the technology readiness of materials and devices critical for future space exploration. The MISSE-X platform will expand ISS utilization by providing experimenters with unprecedented low-cost space access and return on investment (ROI). As a follow-on to the highly successful MISSE series of ISS experiments, MISSE-X will provide advances over the original MISSE configurations including incorporation of plug-and-play experiments that will minimize return mass requirements in the post-Shuttle era, improved active sensing and monitoring of the ISS external environment for better characterization of environmental effects, and expansion of the MISSE-X user community through incorporation of new, customer-desired capabilities. MISSE-X will also foster interest in science, technology, engineering, and math (STEM) in primary and secondary schools through student collaboration and participation.1,2

Inertial-space disturbance rejection for robotic manipulators

NASA Technical Reports Server (NTRS)

Holt, Kevin

1992-01-01

The disturbance rejection control problem for a 6-DOF (degree of freedom) PUMA manipulator mounted on a 3-DOF platform is investigated. A control algorithm is designed to track the desired position and attitude of the end-effector in inertial space, subject to unknown disturbances in the platform axes. Conditions for the stability of the closed-loop system are derived. The performance of the controller is compared for step, sinusoidal, and random disturbances in the platform rotational axis and in the neighborhood of kinematic singularities.

U.S. Space Station platform - Configuration technology for customer servicing

NASA Technical Reports Server (NTRS)

Dezio, Joseph A.; Walton, Barbara A.

1987-01-01

Features of the Space Station coorbiting and polar orbiting platforms (COP and POP, respectively) are described that will allow them to be configured optimally to meet mission requirements and to be assembled, serviced, and modified on-orbit. Both of these platforms were designed to permit servicing at the Shuttle using the remote manipulator system with teleoperated end effectors; EVA was planned as a backup and for unplanned payload failure modes. Station-based servicing is discussed as well as expendable launch vehicle-based servicing concepts.

Space platform utilities distribution study

NASA Technical Reports Server (NTRS)

Lefever, A. E.

1980-01-01

Generic concepts for the installation of power data and thermal fluid distribution lines on large space platforms were discussed. Connections with central utility subsystem modules and pallet interfaces were also considered. Three system concept study platforms were used as basepoints for the detail development. The tradeoff of high voltage low voltage power distribution and the impact of fiber optics as a data distribution mechanism were analyzed. Thermal expansion and temperature control of utility lines and ducts were considered. Technology developments required for implementation of the generic distribution concepts were identified.

Software-Defined Radio for Space-to-Space Communications

NASA Technical Reports Server (NTRS)

Fisher, Ken; Jih, Cindy; Moore, Michael S.; Price, Jeremy C.; Abbott, Ben A.; Fritz, Justin A.

2011-01-01

A paper describes the Space- to-Space Communications System (SSCS) Software- Defined Radio (SDR) research project to determine the most appropriate method for creating flexible and reconfigurable radios to implement wireless communications channels for space vehicles so that fewer radios are required, and commonality in hardware and software architecture can be leveraged for future missions. The ability to reconfigure the SDR through software enables one radio platform to be reconfigured to interoperate with many different waveforms. This means a reduction in the number of physical radio platforms necessary to support a space mission s communication requirements, thus decreasing the total size, weight, and power needed for a mission.

VARiD: a variation detection framework for color-space and letter-space platforms.

PubMed

Dalca, Adrian V; Rumble, Stephen M; Levy, Samuel; Brudno, Michael

2010-06-15

High-throughput sequencing (HTS) technologies are transforming the study of genomic variation. The various HTS technologies have different sequencing biases and error rates, and while most HTS technologies sequence the residues of the genome directly, generating base calls for each position, the Applied Biosystem's SOLiD platform generates dibase-coded (color space) sequences. While combining data from the various platforms should increase the accuracy of variation detection, to date there are only a few tools that can identify variants from color space data, and none that can analyze color space and regular (letter space) data together. We present VARiD--a probabilistic method for variation detection from both letter- and color-space reads simultaneously. VARiD is based on a hidden Markov model and uses the forward-backward algorithm to accurately identify heterozygous, homozygous and tri-allelic SNPs, as well as micro-indels. Our analysis shows that VARiD performs better than the AB SOLiD toolset at detecting variants from color-space data alone, and improves the calls dramatically when letter- and color-space reads are combined. The toolset is freely available at http://compbio.cs.utoronto.ca/varid.

Detail view of fourth level platform winch used to lift ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail view of fourth level platform winch used to lift platform segments away from the Shuttle assembly during testing. - Marshall Space Flight Center, Saturn V Dynamic Test Facility, East Test Area, Huntsville, Madison County, AL

VAB Platform K(2) Lift & Install into Highbay 3

NASA Image and Video Library

2016-03-07

Preparations are underway to lift the second half of the K-level work platforms for NASA’s Space Launch System (SLS) rocket up from High Bay 4 inside the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida. The platform will be lifted up and over the transfer aisle and then lowered into High Bay 3 for installation. It will be secured about 86 feet above the VAB floor, on tower E of the high bay. The K work platforms will provide access to the SLS core stage and solid rocket boosters during processing and stacking operations on the mobile launcher. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to High Bay 3 to support processing of the SLS and Orion spacecraft. A total of 10 levels of new platforms, 20 platform halves altogether, will surround the SLS rocket and Orion spacecraft.

VAB Platform K(2) Lift & Install into Highbay 3

NASA Image and Video Library

2016-03-07

A 250-ton crane is used to lift the second half of the K-level work platforms for NASA’s Space Launch System (SLS) rocket up from High Bay 4 inside the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida. The platform will be lifted up and over the transfer aisle and then lowered into High Bay 3 for installation. It will be secured about 86 feet above the VAB floor, on tower E of the high bay. The K work platforms will provide access to the SLS core stage and solid rocket boosters during processing and stacking operations on the mobile launcher. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to High Bay 3 to support processing of the SLS and Orion spacecraft. A total of 10 levels of new platforms, 20 platform halves altogether, will surround the SLS rocket and Orion spacecraft.

VAB Platform K(2) Lift & Install into Highbay 3

NASA Image and Video Library

2016-03-07

A 250-ton crane is used to lift the second half of the K-level work platforms for NASA’s Space Launch System (SLS) rocket up from High Bay 4 inside the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida. The platform is being lifted up and over the transfer aisle and will be lowered into High Bay 3 for installation. It will be secured about 86 feet above the VAB floor, on tower E of the high bay. The K work platforms will provide access to the SLS core stage and solid rocket boosters during processing and stacking operations on the mobile launcher. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to High Bay 3 to support processing of the SLS and Orion spacecraft. A total of 10 levels of new platforms, 20 platform halves altogether, will surround the SLS rocket and Orion spacecraft.

Laser communications technology with airborne platform

NASA Astrophysics Data System (ADS)

Jiang, Huilin; Liu, Guojun; Yin, Fuchang; Liu, Zhi

2006-01-01

Space laser communications (SLC) possess a series of advantages, such as higher data rates, large capacity of information, very good secrecy, et al. So SLC has been attracting great attention the throughout western and developed countries. USA, EU and Japan are making great efforts in establishing space-air-ground integrated communications network, with satellites, planes or ground vehicles as platforms. China has also carried out laser communication research activities in recent years. Changchun University of Science and technology (CUST) has been doing research studies on space laser communications with plane as the platform, and relatively thorough study on some of the key technologies such as airborne lasercom terminal design. The present paper will address some of these topics.

Synergistic control center development utilizing commercial technology and industry standards. [NASA space programs

NASA Technical Reports Server (NTRS)

Anderson, Brian L.

1993-01-01

The development of the Control Center Complex (CCC), a synergistic control center supporting both the Space Station Freedom and the Space Shuttle Program, is described. To provide maximum growth and flexibility, the CCC uses commercial off-the-shelf technology and industry standards. The discussion covers the development philosophy, CCC architecture, data distribution, the software platform concept, workstation platform, commercial tools for the CCC, and benefits of synergy.

33 CFR 155.400 - Platform machinery space drainage on oceangoing fixed and floating drilling rigs and other...

Code of Federal Regulations, 2011 CFR

2011-07-01

...) Complies with the oily-water separating equipment requirements of a valid National Pollutant Discharge... Chapter I; (2) Complies with the oily-water separating equipment requirements for oceangoing ships of 400... installed bilge pumping system for discharge of oily mixtures from platform machinery spaces into the sea...

33 CFR 155.400 - Platform machinery space drainage on oceangoing fixed and floating drilling rigs and other...

Code of Federal Regulations, 2014 CFR

2014-07-01

...) Complies with the oily-water separating equipment requirements of a valid National Pollutant Discharge... Chapter I; (2) Complies with the oily-water separating equipment requirements for oceangoing ships of 400... installed bilge pumping system for discharge of oily mixtures from platform machinery spaces into the sea...

33 CFR 155.400 - Platform machinery space drainage on oceangoing fixed and floating drilling rigs and other...

Code of Federal Regulations, 2012 CFR

2012-07-01

...) Complies with the oily-water separating equipment requirements of a valid National Pollutant Discharge... Chapter I; (2) Complies with the oily-water separating equipment requirements for oceangoing ships of 400... installed bilge pumping system for discharge of oily mixtures from platform machinery spaces into the sea...

33 CFR 155.400 - Platform machinery space drainage on oceangoing fixed and floating drilling rigs and other...

Code of Federal Regulations, 2013 CFR

2013-07-01

...) Complies with the oily-water separating equipment requirements of a valid National Pollutant Discharge... Chapter I; (2) Complies with the oily-water separating equipment requirements for oceangoing ships of 400... installed bilge pumping system for discharge of oily mixtures from platform machinery spaces into the sea...

KENNEDY SPACE CENTER, FLA. - A worker sandblasts the surface behind the Mobile Launcher Platform on Launch Pad 39A . Routine maintenance includes sandblasting and repainting as preventive means to minimize corrosion.

NASA Image and Video Library

2003-09-12

KENNEDY SPACE CENTER, FLA. - A worker sandblasts the surface behind the Mobile Launcher Platform on Launch Pad 39A . Routine maintenance includes sandblasting and repainting as preventive means to minimize corrosion.

KSC-98pc1180

NASA Image and Video Library

1998-09-28

KENNEDY SPACE CENTER, FLA. -- At left, the payload canister for Space Shuttle Discovery is lifted from its canister movement vehicle to the top of the Rotating Service Structure on Launch Pad 39-B. Discovery (right), sitting atop the Mobile Launch Platform and next to the Fixed Service Structure, is scheduled for launch on Oct. 29, 1998, for the STS-95 mission. That mission includes the International Extreme Ultraviolet Hitchhiker (IEH-3), the Hubble Space Telescope Orbital Systems Test Platform, the Spartan solar-observing deployable spacecraft, and the SPACEHAB single module with experiments on space flight and the aging process

wayGoo: a platform for geolocating and managing indoor and outdoor spaces

NASA Astrophysics Data System (ADS)

Thomopoulos, Stelios C. A.; Karafylli, Christina; Karafylli, Maria; Motos, Dionysis; Lampropoulos, Vassilis; Dimitros, Kostantinos; Margonis, Christos

2016-05-01

wayGoo2 is a platform for Geolocating and Managing indoor and outdoor spaces and content with multidimensional indoor and outdoor Navigation and Guidance. Its main components are a Geographic Information System, a back-end server, front-end applications and a web-based Content Management System (CMS). It constitutes a fully integrated 2D/3D space and content management system that creates a repository that consists of a database, content components and administrative data. wayGoo can connect to any third party database and event management data-source. The platform is secure as the data is only available through a Restful web service using https security protocol in conjunction with an API key used for authentication. To enhance users experience, wayGoo makes the content available by extracting components out of the repository and constructing targeted applications. The wayGoo platform supports geo-referencing of indoor and outdoor information and use of metadata. It also allows the use of existing information such as maps and databases. The platform enables planning through integration of content that is connected either spatially, temporally or contextually, and provides immediate access to all spatial data through interfaces and interactive 2D and 3D representations. wayGoo constitutes a mean to document and preserve assets through computerized techniques and provides a system that enhances the protection of your space, people and guests when combined with wayGoo notification and alert system. It constitutes a strong marketing tool providing staff and visitors with an immersive tool for navigation in indoor spaces and allowing users to organize their agenda and to discover events through wayGoo event scheduler and recommendation system. Furthermore, the wayGoo platform can be used in Security applications and event management, e.g. CBRNE incidents, man-made and natural disasters, etc., to document and geolocate information and sensor data (off line and real time) on one end, and offer navigation capabilities in indoor and outdoor spaces. Furthermore, the wayGoo platform can be used for the creation of immersive environments and experiences in conjunction with VR/AR (Virtual and Augmented Reality) technologies.

Stabilized floating platforms

DOEpatents

Thomas, David G.

1976-01-01

The subject invention is directed to a floating platform for supporting nuclear reactors and the like at selected offshore sites. The platform is provided with a stabilizer mechanism which significantly reduces the effects of wave action upon the platform and which comprises a pair of relatively small floats attached by rigid booms to the platform at locations spaced therefrom for reducing wave pitch, acceleration, and the resonance period of the wave.

Resistant Bacterial Spore Coats and Their Breakdown During Germination

DTIC Science & Technology

2010-01-01

proteins are released into the outer layers of the spore (SspA, B) or released into the supernatant ( SspE ). 4. Two major proteases of broad...40 30 20 15 10 3.5 N o ve x Sh ar p cw lD ge rm in at io n e xu d at e N o ve x Sh ar p cw lD ge rm in at io n e xu d at e CotA CotQ SodA SspE ...Finally, and unexpectedly, SspE , the major gamma-type SASP (small acid soluble protein) present in the inner cellular compartment of dormant spores, and

JWST ISIM test platform

NASA Image and Video Library

2010-03-17

A view inside the NASA Goddard clean room where the James Webb Space Telescope (JWST) is being built. This images shows Goddard technicians lifting the ISIM (Integrated Science Instrument Module) onto the ITS (ISIM Test Structure). ISIM will sit atop this platform during space environmental testing. Credit: NASA/GSFC/Chris Gunn For more information on JWST go to: www.jwst.nasa.gov/ For more information on Goddard Space Flight Center go to: www.nasa.gov/centers/goddard/home/index.html

Erectable/deployable concepts for large space system technology

NASA Technical Reports Server (NTRS)

Agan, W. E.

1980-01-01

Erectable/deployable space structure concepts particularly relating to the development of a science and applications space platform are presented. Design and operating features for an automatic coupler clevis joint, a side latching detent joint, and a module-to-module auto lock coupler are given. An analysis of the packaging characteristics of stacked subassembly, single fold, hybrid, and double fold concepts is given for various platform structure configurations. Payload carrier systems and assembly techniques are also discussed.

Design and Performance of a Spectrometer for Deployment on MISSE 7

NASA Technical Reports Server (NTRS)

Pippin, Gary; Beymer, Jim; Robb, Andrew; Longino, James; Perry, George; Stewart, Alan; Finkenor, Miria

2009-01-01

A spectrometer for reflectance and transmission measurements of samples exposed to the space environment has been developed for deployment on the Materials on the International Space Station Experiment (MISSE) 7. The instrument incorporates a miniature commercial fiber optic coupled spectrometer with a computer control system for detector operation, sample motion and illumination. A set of three spectrometers were recently integrated on the MISSE7 platform with launch and deployment on the International Space Station scheduled for summer of this year. The instrument is one of many active experiments on the platform. The performance of the instrument prior to launch will be discussed. Data from samples measured in the laboratory will be compared to those from the instrument prior to launch. These comparisons will illustrate the capabilities of the current design. The space environment challenges many materials. When in operation on the MISSE 7 platform, the new spectrometer will provide real time data on the how the space environment affects the optical properties of thermal control paints and optical coatings. Data obtained from comparison of pre and post flight measurements on hundreds of samples exposed on previous MISSE platforms have been reported at these meetings. With the new spectrometer and the ability to correlate measured changes with time on orbit and the occurrence of both natural events and human activities, a better understanding of the processes responsible for degradation of materials in space will be possible.

Adaptive control of a Stewart platform-based manipulator

NASA Technical Reports Server (NTRS)

Nguyen, Charles C.; Antrazi, Sami S.; Zhou, Zhen-Lei; Campbell, Charles E., Jr.

1993-01-01

A joint-space adaptive control scheme for controlling noncompliant motion of a Stewart platform-based manipulator (SPBM) was implemented in the Hardware Real-Time Emulator at Goddard Space Flight Center. The six-degrees of freedom SPBM uses two platforms and six linear actuators driven by dc motors. The adaptive control scheme is based on proportional-derivative controllers whose gains are adjusted by an adaptation law based on model reference adaptive control and Liapunov direct method. It is concluded that the adaptive control scheme provides superior tracking capability as compared to fixed-gain controllers.

Microflow1, a sheathless fiber-optic flow cytometry biomedical platform: demonstration onboard the international space station.

PubMed

Dubeau-Laramée, Geneviève; Rivière, Christophe; Jean, Isabelle; Mermut, Ozzy; Cohen, Luchino Y

2014-04-01

A fiber-optic based flow cytometry platform was designed to build a portable and robust instrument for space applications. At the core of the Microflow1 is a unique fiber-optic flow cell fitted to a fluidic system and fiber coupled to the source and detection channels. A Microflow1 engineering unit was first tested and benchmarked against a commercial flow cytometer as a reference in a standard laboratory environment. Testing in parabolic flight campaigns was performed to establish Microflow1's performance in weightlessness, before operating the new platform on the International Space Station. Microflow1 had comparable performances to commercial systems, and operated remarkably and robustly in weightlessness (microgravity). Microflow1 supported immunophenotyping as well as microbead-based multiplexed cytokine assays in the space environment and independently of gravity levels. Results presented here provide evidence that this fiber-optic cytometer technology is inherently compatible with the space environment with negligible compromise to analytical performance. © 2013 International Society for Advancement of Cytometry.

An optical approach to proximity-operations communications for Space Station Freedom

NASA Technical Reports Server (NTRS)

Marshalek, Robert G.

1991-01-01

An optical communications system is described that supports bi-directional interconnections between Space Station Freedom (SSF) and a host of attached and co-orbiting platforms. These proximity-operations (Prox-Ops) platforms are categorized by their maximum distance from SSF, with several remaining inside 1-km range and several extending out to 37-km and 2000-km ranges in the initial and growth phases, respectively. Two distinct Prox-Ops optical terminals are described. A 1-cm-aperture system is used on the short-range platforms to reduce payload mass, and a 10-cm-aperture system is used on the long-range platforms and on SSF to support the optical link budgets. The system supports up to four simultaneous user links, by assigning wavelengths to the various platforms and by using separate SSF terminals for each link.

KENNEDY SPACE CENTER, FLA. - Sandblasting begins on the Mobile Launcher Platform on Launch Pad 39A to remove corrosion before repainting. Routine maintenance includes sandblasting and repainting as preventive means to minimize corrosion.

NASA Image and Video Library

2003-09-12

KENNEDY SPACE CENTER, FLA. - Sandblasting begins on the Mobile Launcher Platform on Launch Pad 39A to remove corrosion before repainting. Routine maintenance includes sandblasting and repainting as preventive means to minimize corrosion.

Radiation Hardening by Software Techniques on FPGAs: Flight Experiment Evaluation and Results

NASA Technical Reports Server (NTRS)

Schmidt, Andrew G.; Flatley, Thomas

2017-01-01

We present our work on implementing Radiation Hardening by Software (RHBSW) techniques on the Xilinx Virtex5 FPGAs PowerPC 440 processors on the SpaceCube 2.0 platform. The techniques have been matured and tested through simulation modeling, fault emulation, laser fault injection and now in a flight experiment, as part of the Space Test Program- Houston 4-ISS SpaceCube Experiment 2.0 (STP-H4-ISE 2.0). This work leverages concepts such as heartbeat monitoring, control flow assertions, and checkpointing, commonly used in the High Performance Computing industry, and adapts them for use in remote sensing embedded systems. These techniques are extremely low overhead (typically <1.3%), enabling a 3.3x gain in processing performance as compared to the equivalent traditionally radiation hardened processor. The recently concluded STP-H4 flight experiment was an opportunity to upgrade the RHBSW techniques for the Virtex5 FPGA and demonstrate them on-board the ISS to achieve TRL 7. This work details the implementation of the RHBSW techniques, that were previously developed for the Virtex4-based SpaceCube 1.0 platform, on the Virtex5-based SpaceCube 2.0 flight platform. The evaluation spans the development and integration with flight software, remotely uploading the new experiment to the ISS SpaceCube 2.0 platform, and conducting the experiment continuously for 16 days before the platform was decommissioned. The experiment was conducted on two PowerPCs embedded within the Virtex5 FPGA devices and the experiment collected 19,400 checkpoints, processed 253,482 status messages, and incurred 0 faults. These results are highly encouraging and future work is looking into longer duration testing as part of the STP-H5 flight experiment.

Space platform expendables resupply concept definition study. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

1984-01-01

NASA has recognized that the capability for remote resupply of space platform expendable fluids will help transition space utilization into a new era of operational efficiency and cost/effectiveness. The emerging Orbital Maneuvering System (OMV) in conjunction with an expendables resupply module will introduce the capability for fluid resupply enabling satellite lifetime extension at locations beyond the range of the Orbiter. This report summarizes a Phase A study of a remote resupply module for the OMV. Volume 1 is the executive summary.

Space platform expendables resupply concept definition study

NASA Technical Reports Server (NTRS)

1985-01-01

NASA has recognized that the capability for remote resupply of space platform expendable fluids will help transition space utilization into a new era of operational efficiency and cost/effectiveness. The emerging Orbital Maneuvering System (OMV) in conjunction with an expendables resupply module will introduce the capability for fluid resupply enabling satellite lifetime extension at locations beyond the range of the Orbiter. This report summarizes a supplemental study to the original Phase A study and is presented as addenda to that study.

Space platform expendables resupply concept definition study, volume 2

NASA Technical Reports Server (NTRS)

1984-01-01

NASA has recognized that the capability for remote resupply of space platform expendable fluids will help transition space utilization into a new era of operational efficiency and cost/effectiveness. The emerging Orbital Maneuvering System (OMV) in conjunction with an expendables resupply module will introduce the capability for fluid resupply enabling satellite lifetime extension at locations beyond the range of the Orbiter. This report summarizes a Phase A study of a remote resupply module for the OMV. Volume 2 represents study results.

The Capabilities of Space Stations

NASA Technical Reports Server (NTRS)

1995-01-01

Over the past two years the U.S. space station program has evolved to a three-phased international program, with the first phase consisting of the use of the U.S. Space Shuttle and the upgrading and use of the Russian Mir Space Station, and the second and third phases consisting of the assembly and use of the new International Space Station. Projected capabilities for research, and plans for utilization, have also evolved and it has been difficult for those not directly involved in the design and engineering of these space stations to learn and understand their technical details. The Committee on the Space Station of the National Research Council, with the concurrence of NASA, undertook to write this short report in order to provide concise and objective information on space stations and platforms -- with emphasis on the Mir Space Station and International Space Station -- and to supply a summary of the capabilities of previous, existing, and planned space stations. In keeping with the committee charter and with the task statement for this report, the committee has summarized the research capabilities of five major space platforms: the International Space Station, the Mir Space Station, the Space Shuttle (with a Spacelab or Spacehab module in its cargo bay), the Space Station Freedom (which was redesigned to become the International Space Station in 1993 and 1994), and Skylab. By providing the summary, together with brief descriptions of the platforms, the committee hopes to assist interested readers, including scientists and engineers, government officials, and the general public, in evaluating the utility of each system to meet perceived user needs.

SO-QT: Collaborative Tool to Project the Future Space Object Population

NASA Technical Reports Server (NTRS)

Stupl, Jan

2017-01-01

Earth orbit gets increasingly congested, a challenge to space operators, both in governments and industry. We present a web tool that provides: 1) data on todays and the historic space object environments, by aggregating object-specific tracking data; and 2) future trends through a collaboration platform to collect information on planed launches. The collaborative platform enables experts to pool and compare their data in order to generate future launch scenarios. The tool is intended to support decision makers and mission designers while they investigate future missions and scholars as they develop strategies for space traffic management.

The exploration about the means of lunar-landing based on space-launch

NASA Astrophysics Data System (ADS)

Yi, Jiang; Zheming, Zhang; Debin, Fu

The lunar exploration and lunar-landing is the first step of china s deep space exploration On the basement of our country s achievements and the experiences of the foreign countries the paper brings forward the idea that use the existing transportation technology to sent the Launch vehicles and cosmonauts to the near-earth orbit in batches assemble the components together on the Space-launch Platform and then launch them to the Moon to fulfill our dream of manned landing on the moon The paper also discusses the Space-launch Platform and the launching way

STS-95 Space Shuttle Discovery rollout to Launch Pad 39B

NASA Technical Reports Server (NTRS)

1998-01-01

Perched on the Mobile Launch Platform, in the early morning hours Space Shuttle Discovery approaches Launch Complex Pad 39B after a 6-hour, 4.2-mile trip from the Vehicle Assembly Building. At the launch pad, the orbiter, external tank and solid rocket boosters will undergo final preparations for the launch, scheduled to lift off Oct. 29. The mission includes research payloads such as the Spartan solar-observing deployable spacecraft, the Hubble Space Telescope Orbital Systems Test Platform, the International Extreme Ultraviolet Hitchhiker, as well as the SPACEHAB single module with experiments on space flight and the aging process.

New norms new policies: Did the Adelaide Thinkers in Residence scheme encourage new thinking about promoting well-being and Health in All Policies?

PubMed

Baum, Fran; Lawless, Angela; MacDougall, Colin; Delany, Toni; McDermott, Dennis; Harris, Elizabeth; Williams, Carmel

2015-12-01

Health systems have long been criticised for focussing on curing rather than preventing disease. This paper examines to what extent the Adelaide Thinkers in Residence (ATiR) scheme contributed to the change in norms whereby promoting well-being and a strategy to achieve this - Health in All Policies (HiAP)--was adopted by the South Australian (SA) State Government from 2007. The data presented in this paper are drawn from a five year (2012-2016) detailed mixed methods case study of the SA HiAP initiative which involved document analysis, interviews and workshops with public servants and political actors. We adapt the framework used by Finnemore and Sikkink (1998) which explains how norm changes can lead to political changes in international affairs. We also use Kingdon's concept of policy entrepreneurs to determine whether these ideas moved to an implementable initiative with the help of both a specific ATiR program on HiAP and the broader TiR scheme which promoted a series of innovations relevant to health. The process involved the ATiR reinforcing the work of local norm entrepreneurs with that of powerful external policy entrepreneurs, adapting the discourse about the value of prevention and promoting well-being so that it fitted with the dominant economic one. The powerful organisational platform of the ATiR, which was under the Department of the Premier and Cabinet and linked to the South Australian Strategic Plan (SASP) was used to advance these ideas. The case study offers important lessons for other jurisdictions on how to shift policy to encourage intersectoral approaches to health. Copyright © 2015 Elsevier Ltd. All rights reserved.

Towards Autonomous Inspection of Space Systems Using Mobile Robotic Sensor Platforms

NASA Technical Reports Server (NTRS)

Wong, Edmond; Saad, Ashraf; Litt, Jonathan S.

2007-01-01

The space transportation systems required to support NASA's Exploration Initiative will demand a high degree of reliability to ensure mission success. This reliability can be realized through autonomous fault/damage detection and repair capabilities. It is crucial that such capabilities are incorporated into these systems since it will be impractical to rely upon Extra-Vehicular Activity (EVA), visual inspection or tele-operation due to the costly, labor-intensive and time-consuming nature of these methods. One approach to achieving this capability is through the use of an autonomous inspection system comprised of miniature mobile sensor platforms that will cooperatively perform high confidence inspection of space vehicles and habitats. This paper will discuss the efforts to develop a small scale demonstration test-bed to investigate the feasibility of using autonomous mobile sensor platforms to perform inspection operations. Progress will be discussed in technology areas including: the hardware implementation and demonstration of robotic sensor platforms, the implementation of a hardware test-bed facility, and the investigation of collaborative control algorithms.

Study on photon transport problem based on the platform of molecular optical simulation environment.

PubMed

Peng, Kuan; Gao, Xinbo; Liang, Jimin; Qu, Xiaochao; Ren, Nunu; Chen, Xueli; Ma, Bin; Tian, Jie

2010-01-01

As an important molecular imaging modality, optical imaging has attracted increasing attention in the recent years. Since the physical experiment is usually complicated and expensive, research methods based on simulation platforms have obtained extensive attention. We developed a simulation platform named Molecular Optical Simulation Environment (MOSE) to simulate photon transport in both biological tissues and free space for optical imaging based on noncontact measurement. In this platform, Monte Carlo (MC) method and the hybrid radiosity-radiance theorem are used to simulate photon transport in biological tissues and free space, respectively, so both contact and noncontact measurement modes of optical imaging can be simulated properly. In addition, a parallelization strategy for MC method is employed to improve the computational efficiency. In this paper, we study the photon transport problems in both biological tissues and free space using MOSE. The results are compared with Tracepro, simplified spherical harmonics method (SP(n)), and physical measurement to verify the performance of our study method on both accuracy and efficiency.

Study on Photon Transport Problem Based on the Platform of Molecular Optical Simulation Environment

PubMed Central

Peng, Kuan; Gao, Xinbo; Liang, Jimin; Qu, Xiaochao; Ren, Nunu; Chen, Xueli; Ma, Bin; Tian, Jie

2010-01-01

As an important molecular imaging modality, optical imaging has attracted increasing attention in the recent years. Since the physical experiment is usually complicated and expensive, research methods based on simulation platforms have obtained extensive attention. We developed a simulation platform named Molecular Optical Simulation Environment (MOSE) to simulate photon transport in both biological tissues and free space for optical imaging based on noncontact measurement. In this platform, Monte Carlo (MC) method and the hybrid radiosity-radiance theorem are used to simulate photon transport in biological tissues and free space, respectively, so both contact and noncontact measurement modes of optical imaging can be simulated properly. In addition, a parallelization strategy for MC method is employed to improve the computational efficiency. In this paper, we study the photon transport problems in both biological tissues and free space using MOSE. The results are compared with Tracepro, simplified spherical harmonics method (S P n), and physical measurement to verify the performance of our study method on both accuracy and efficiency. PMID:20445737

Strategies Used by Professors through Virtual Educational Platforms in Face-to-Face Classes: A View from the Chamilo Platform

ERIC Educational Resources Information Center

Valencia, Heriberto Gonzalez; Villota Enriquez, Jackeline Amparo; Agredo, Patricia Medina

2017-01-01

This study consisted in characterizing the strategies used by professors; implemented through virtual educational platforms. The context of this research were the classrooms of the Santiago de Cali University and the virtual space of the Chamilo virtual platform, where two professors from the Faculty of Education of the same university…

KENNEDY SPACE CENTER, FLA. - - In the Space Station Processing Facility, STS-114 Mission Specialist Stephen Robinson (left) learns about the Japanese Experiment Module (JEM) from Jennifer Goldsmith (center), with United Space Alliance at Johnson Space Center, and Louise Kleba (right), with USA at KSC. Crew members are at KSC to become familiar with Shuttle and mission equipment. The mission is Logistics Flight 1, which is scheduled to deliver supplies and equipment plus the external stowage platform to the International Space Station.

NASA Image and Video Library

2004-03-05

KENNEDY SPACE CENTER, FLA. - - In the Space Station Processing Facility, STS-114 Mission Specialist Stephen Robinson (left) learns about the Japanese Experiment Module (JEM) from Jennifer Goldsmith (center), with United Space Alliance at Johnson Space Center, and Louise Kleba (right), with USA at KSC. Crew members are at KSC to become familiar with Shuttle and mission equipment. The mission is Logistics Flight 1, which is scheduled to deliver supplies and equipment plus the external stowage platform to the International Space Station.

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, STS-114 Mission Specialist Stephen Robinson (right) learns about the Japanese Experiment Module (JEM) from Louise Kleba (left), with United Space Alliance at KSC, and Jennifer Goldsmith (center), with USA at Johnson Space Center. Crew members are at KSC becoming familiar with Shuttle and mission equipment. The mission is Logistics Flight 1, which is scheduled to deliver supplies and equipment plus the external stowage platform to the International Space Station.

NASA Image and Video Library

2004-03-05

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, STS-114 Mission Specialist Stephen Robinson (right) learns about the Japanese Experiment Module (JEM) from Louise Kleba (left), with United Space Alliance at KSC, and Jennifer Goldsmith (center), with USA at Johnson Space Center. Crew members are at KSC becoming familiar with Shuttle and mission equipment. The mission is Logistics Flight 1, which is scheduled to deliver supplies and equipment plus the external stowage platform to the International Space Station.

Progress at Standard Space Platforms Corporation

NASA Astrophysics Data System (ADS)

Perkins, Frederick W.

1992-08-01

An account is given of a simple program structure with low costs and short schedules for the space R&D community operating outside mission-oriented, government-funded programs. In addition to furnishing launch services into orbit, the program structure furnishes engineering services through its ground station, control room, and 3-year duration 'MMSB' platform. Flights may begin as little as a year after contract signature.

Hardware Interface Description for the Integrated Power, Avionics, and Software (iPAS) Space Telecommunications Radio Ssystem (STRS) Radio

NASA Technical Reports Server (NTRS)

Shalkhauser, Mary Jo W.; Roche, Rigoberto

2017-01-01

The Space Telecommunications Radio System (STRS) provides a common, consistent framework for software defined radios (SDRs) to abstract the application software from the radio platform hardware. The STRS standard aims to reduce the cost and risk of using complex, configurable and reprogrammable radio systems across NASA missions. To promote the use of the STRS architecture for future NASA advanced exploration missions, NASA Glenn Research Center (GRC) developed an STRS-compliant SDR on a radio platform used by the Advance Exploration System program at the Johnson Space Center (JSC) in their Integrated Power, Avionics, and Software (iPAS) laboratory. The iPAS STRS Radio was implemented on the Reconfigurable, Intelligently-Adaptive Communication System (RIACS) platform, currently being used for radio development at JSC. The platform consists of a Xilinx ML605 Virtex-6 FPGA board, an Analog Devices FMCOMMS1-EBZ RF transceiver board, and an Embedded PC (Axiomtek eBox 620-110-FL) running the Ubuntu 12.4 operating system. Figure 1 shows the RIACS platform hardware. The result of this development is a very low cost STRS compliant platform that can be used for waveform developments for multiple applications.The purpose of this document is to describe how to develop a new waveform using the RIACS platform and the Very High Speed Integrated Circuits (VHSIC) Hardware Description Language (VHDL) FPGA wrapper code and the STRS implementation on the Axiomtek processor.

Microgravity vibration isolation: An optimal control law for the one-dimensional case

NASA Technical Reports Server (NTRS)

Hampton, Richard D.; Grodsinsky, Carlos M.; Allaire, Paul E.; Lewis, David W.; Knospe, Carl R.

1991-01-01

Certain experiments contemplated for space platforms must be isolated from the accelerations of the platform. An optimal active control is developed for microgravity vibration isolation, using constant state feedback gains (identical to those obtained from the Linear Quadratic Regulator (LQR) approach) along with constant feedforward gains. The quadratic cost function for this control algorithm effectively weights external accelerations of the platform disturbances by a factor proportional to (1/omega) exp 4. Low frequency accelerations are attenuated by greater than two orders of magnitude. The control relies on the absolute position and velocity feedback of the experiment and the absolute position and velocity feedforward of the platform, and generally derives the stability robustness characteristics guaranteed by the LQR approach to optimality. The method as derived is extendable to the case in which only the relative positions and velocities and the absolute accelerations of the experiment and space platform are available.

Microgravity vibration isolation: An optimal control law for the one-dimensional case

NASA Technical Reports Server (NTRS)

Hampton, R. D.; Grodsinsky, C. M.; Allaire, P. E.; Lewis, D. W.; Knospe, C. R.

1991-01-01

Certain experiments contemplated for space platforms must be isolated from the accelerations of the platforms. An optimal active control is developed for microgravity vibration isolation, using constant state feedback gains (identical to those obtained from the Linear Quadratic Regulator (LQR) approach) along with constant feedforward (preview) gains. The quadratic cost function for this control algorithm effectively weights external accelerations of the platform disturbances by a factor proportional to (1/omega)(exp 4). Low frequency accelerations (less than 50 Hz) are attenuated by greater than two orders of magnitude. The control relies on the absolute position and velocity feedback of the experiment and the absolute position and velocity feedforward of the platform, and generally derives the stability robustness characteristics guaranteed by the LQR approach to optimality. The method as derived is extendable to the case in which only the relative positions and velocities and the absolute accelerations of the experiment and space platform are available.

Low-gravity Orbiting Research Laboratory Environment Potential Impact on Space Biology Research

NASA Technical Reports Server (NTRS)

Jules, Kenol

2006-01-01

One of the major objectives of any orbital space research platform is to provide a quiescent low gravity, preferably a zero gravity environment, to perform fundamental as well as applied research. However, small disturbances exist onboard any low earth orbital research platform. The impact of these disturbances must be taken into account by space research scientists during their research planning, design and data analysis in order to avoid confounding factors in their science results. The reduced gravity environment of an orbiting research platform in low earth orbit is a complex phenomenon. Many factors, among others, such as experiment operations, equipment operation, life support systems and crew activity (if it is a crewed platform), aerodynamic drag, gravity gradient, rotational effects as well as the vehicle structural resonance frequencies (structural modes) contribute to form the overall reduced gravity environment in which space research is performed. The contribution of these small disturbances or accelerations is precisely why the environment is NOT a zero gravity environment, but a reduced acceleration environment. This paper does not discuss other factors such as radiation, electromagnetic interference, thermal and pressure gradient changes, acoustic and CO2 build-up to name a few that affect the space research environment as well, but it focuses solely on the magnitude of the acceleration level found on orbiting research laboratory used by research scientists to conduct space research. For ease of analysis this paper divides the frequency spectrum relevant to most of the space research disciplines into three regimes: a) quasi-steady, b) vibratory and c) transient. The International Space Station is used as an example to illustrate the point. The paper discusses the impact of these three regimes on space biology research and results from space flown experiments are used to illustrate the potential negative impact of these disturbances (accelerations) on space biology research.

KSC-98pc1136

NASA Image and Video Library

1998-09-23

KENNEDY SPACE CENTER, FLA. -- The Hubble Space Telescope Orbiting Systems Test Platform (HOST) is lifted off its work stand in the Space Station Processing Facility before moving it to its payload canister. One of the payloads on the STS-95 mission, the HOST platform is carrying four experiments to validate components planned for installation during the third Hubble Space Telescope servicing mission and to evaluate new technologies in an Earth-orbiting environment. The STS-95 mission is scheduled to launch Oct. 29. It will carry other payloads such as the Spartan solar-observing deployable spacecraft, the International Extreme Ultraviolet Hitchhiker (IEH-3), and the SPACEHAB single module with experiments on space flight and the aging process

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, astronaut Lee Archambault and STS-114 Mission Specialist Charles Camarda watch as crew members work with equipment that will be used on the mission. Archambault supports launch and landing operations at the Kennedy Space Center as an Astronaut Office representative. Crew members are at KSC for equipment familiarization. STS-114 is classified as Logistics Flight 1 to the International Space Station, delivering new supplies and replacing one of the orbital outpost’s Control Moment Gyroscopes (CMGs). STS-114 will also carry a Raffaello Multi-Purpose Logistics Module and the External Stowage Platform-2. The crew is slated to conduct at least three spacewalks: They will demonstrate repair techniques of the Shuttle’s Thermal Protection System, replace the failed CMG with one delivered by the Shuttle, and install the External Stowage Platform.

NASA Image and Video Library

2004-01-27

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, astronaut Lee Archambault and STS-114 Mission Specialist Charles Camarda watch as crew members work with equipment that will be used on the mission. Archambault supports launch and landing operations at the Kennedy Space Center as an Astronaut Office representative. Crew members are at KSC for equipment familiarization. STS-114 is classified as Logistics Flight 1 to the International Space Station, delivering new supplies and replacing one of the orbital outpost’s Control Moment Gyroscopes (CMGs). STS-114 will also carry a Raffaello Multi-Purpose Logistics Module and the External Stowage Platform-2. The crew is slated to conduct at least three spacewalks: They will demonstrate repair techniques of the Shuttle’s Thermal Protection System, replace the failed CMG with one delivered by the Shuttle, and install the External Stowage Platform.

Future Standardization of Space Telecommunications Radio System with Core Flight System

NASA Technical Reports Server (NTRS)

Hickey, Joseph P.; Briones, Janette C.; Roche, Rigoberto; Handler, Louis M.; Hall, Steven

2016-01-01

NASA Glenn Research Center (GRC) is integrating the NASA Space Telecommunications Radio System (STRS) Standard with the Core Flight System (cFS). The STRS standard provides a common, consistent framework to develop, qualify, operate and maintain complex, reconfigurable and reprogrammable radio systems. The cFS is a flexible, open architecture that features a plug-and-play software executive called the Core Flight Executive (cFE), a reusable library of software components for flight and space missions and an integrated tool suite. Together, STRS and cFS create a development environment that allows for STRS compliant applications to reference the STRS APIs through the cFS infrastructure. These APis are used to standardize the communication protocols on NASAs space SDRs. The cFE-STRS Operating Environment (OE) is a portable cFS library, which adds the ability to run STRS applications on existing cFS platforms. The purpose of this paper is to discuss the cFE-STRS OE prototype, preliminary experimental results performed using the Advanced Space Radio Platform (ASRP), the GRC Sband Ground Station and the SCaN (Space Communication and Navigation) Testbed currently flying onboard the International Space Station. Additionally, this paper presents a demonstration of the Consultative Committee for Space Data Systems (CCSDS) Spacecraft Onboard Interface Services (SOIS) using electronic data sheets inside cFE. This configuration allows for the data sheets to specify binary formats for data exchange between STRS applications. The integration of STRS with cFS leverages mission-proven platform functions and mitigates barriers to integration with future missions. This reduces flight software development time and the costs of software-defined radio (SDR) platforms. Furthermore, the combined benefits of STRS standardization with the flexibility of cFS provide an effective, reliable and modular framework to minimize software development efforts for spaceflight missions.

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, STS-114 Mission Specialist Andrew Thomas (left) works with equipment while Mission Specialist Soichi Noguchi watches. Noguchi is with the Japanese Aerospace Exploration Agency (JAXA). They and other crew members are at KSC for equipment familiarization. STS-114 is classified as Logistics Flight 1 to the International Space Station, delivering new supplies and replacing one of the orbital outpost’s Control Moment Gyroscopes (CMGs). STS-114 will also carry a Raffaello Multi-Purpose Logistics Module and the External Stowage Platform-2. The crew is slated to conduct at least three spacewalks: They will demonstrate repair techniques of the Shuttle’s Thermal Protection System, replace the failed CMG with one delivered by the Shuttle, and install the External Stowage Platform.

NASA Image and Video Library

2004-01-27

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, STS-114 Mission Specialist Andrew Thomas (left) works with equipment while Mission Specialist Soichi Noguchi watches. Noguchi is with the Japanese Aerospace Exploration Agency (JAXA). They and other crew members are at KSC for equipment familiarization. STS-114 is classified as Logistics Flight 1 to the International Space Station, delivering new supplies and replacing one of the orbital outpost’s Control Moment Gyroscopes (CMGs). STS-114 will also carry a Raffaello Multi-Purpose Logistics Module and the External Stowage Platform-2. The crew is slated to conduct at least three spacewalks: They will demonstrate repair techniques of the Shuttle’s Thermal Protection System, replace the failed CMG with one delivered by the Shuttle, and install the External Stowage Platform.

Orbiter processing facility service platform failure and redesign

NASA Technical Reports Server (NTRS)

Harris, Jesse L.

1988-01-01

In a high bay of the Orbiter Processing Facility (OPF) at the Kennedy Space Center, technicians were preparing the space shuttle orbiter Discovery for rollout to the Vehicle Assembly Building (VAB). A service platform, commonly referred to as an OPF Bucket, was being retracted when it suddenly fell, striking a technician and impacting Discovery's payload bay door. A critical component in the OPF Bucket hoist system had failed, allowing the platform to fall. The incident was thoroughly investigated by both NASA and Lockheed, revealing many design deficiencies within the system. The deficiencies and the design changes made to correct them are reviewed.

SLS Booster Engine Service Platforms Delivery

NASA Image and Video Library

2017-07-31

A flatbed truck carrying one of two new service platforms for NASA's Space Launch System booster engines nears the Vehicle Assembly Building (VAB) at the agency's Kennedy Space Center in Florida. The platforms were transported from fabricator Met-Con Inc. in Cocoa, Florida. They will be delivered to the VAB, where they will be stored and used for processing and checkout of the engines for the rocket's twin five-segment solid rocket boosters for Exploration Mission-1. EM-1 will launch an uncrewed Orion spacecraft to a stable orbit beyond the Moon and bring it back to Earth for a splashdown in the Pacific Ocean.

Booster Engine Service Platforms Delivered to VAB

NASA Image and Video Library

2018-04-17

A new service platform for NASA's Space Launch System booster engines is being prepared for the move into the Vehicle Assembly Building (VAB) at the agency's Kennedy Space Center in Florida. The platform was transported from fabricator Met-Con Inc. in Cocoa, Florida. It will be stored in the VAB, and used for processing and checkout of the engines for the rocket's twin five-segment solid rocket boosters for Exploration Mission-1. EM-1 will launch an uncrewed Orion spacecraft to a stable orbit beyond the Moon and bring it back to Earth for a splashdown in the Pacific Ocean.

SLS Booster Engine Service Platforms Delivery

NASA Image and Video Library

2017-07-31

A flatbed truck carrying one of two new service platforms for NASA's Space Launch System booster engines backs up inside the Vehicle Assembly Building (VAB) at the agency's Kennedy Space Center in Florida. The platforms were transported from fabricator Met-Con Inc. in Cocoa, Florida. They will be stored in the VAB, where they will be used for processing and checkout of the engines for the rocket's twin five-segment solid rocket boosters for Exploration Mission-1. EM-1 will launch an uncrewed Orion spacecraft to a stable orbit beyond the Moon and bring it back to Earth for a splashdown in the Pacific Ocean.

SLS Booster Engine Service Platforms Delivery

NASA Image and Video Library

2017-07-31

A flatbed truck carrying one of two new service platforms for NASA's Space Launch System booster engines backs in to the Vehicle Assembly Building (VAB) at the agency's Kennedy Space Center in Florida. The platforms were transported from fabricator Met-Con Inc. in Cocoa, Florida. They will be stored in the VAB, where they will be used for processing and checkout of the engines for the rocket's twin five-segment solid rocket boosters for Exploration Mission-1. EM-1 will launch an uncrewed Orion spacecraft to a stable orbit beyond the Moon and bring it back to Earth for a splashdown in the Pacific Ocean.

SLS Booster Engine Service Platforms Delivery

NASA Image and Video Library

2017-07-31

A flatbed truck carrying one of two new service platforms for NASA's Space Launch System booster engines arrives inside the Vehicle Assembly Building (VAB) at the agency's Kennedy Space Center in Florida. The platforms were transported from fabricator Met-Con Inc. in Cocoa, Florida. They will be stored in the VAB, where they will be used for processing and checkout of the engines for the rocket's twin five-segment solid rocket boosters for Exploration Mission-1. EM-1 will launch an uncrewed Orion spacecraft to a stable orbit beyond the Moon and bring it back to Earth for a splashdown in the Pacific Ocean.

SLS Booster Engine Service Platforms Delivery

NASA Image and Video Library

2017-07-31

A flatbed truck carrying one of two new service platforms for NASA's Space Launch System booster engines arrives at the Vehicle Assembly Building (VAB) at the agency's Kennedy Space Center in Florida. The platforms were transported from fabricator Met-Con Inc. in Cocoa, Florida. They will be stored in the VAB, where they will be used for processing and checkout of the engines for the rocket's twin five-segment solid rocket boosters for Exploration Mission-1. EM-1 will launch an uncrewed Orion spacecraft to a stable orbit beyond the Moon and bring it back to Earth for a splashdown in the Pacific Ocean.

SLS Booster Engine Service Platforms Delivery

NASA Image and Video Library

2017-07-31

New service platforms for NASA's Space Launch System booster engines, secured on two flatbed trucks, are on their way to the agency's Kennedy Space Center in Florida. They are being transported from fabricator Met-Con Inc. in Cocoa, Florida. The platforms will be delivered to the Vehicle Assembly Building, where they will be stored and used for processing and checkout of the engines for the rocket's twin five-segment solid rocket boosters for Exploration Mission-1. EM-1 will launch an uncrewed Orion spacecraft to a stable orbit beyond the Moon and bring it back to Earth for a splashdown in the Pacific Ocean.

SLS Booster Engine Service Platforms Delivery

NASA Image and Video Library

2017-07-31

One of two new work platforms for NASA's Space Launch System booster engines is secured on dunnage inside the Vehicle Assembly Building (VAB) at the agency's Kennedy Space Center in Florida. The platforms were transported from fabricator Met-Con Inc. in Cocoa, Florida. They will be stored in the VAB, where they will be used for processing and checkout of the engines for the rocket's twin five-segment solid rocket boosters for Exploration Mission-1. EM-1 will launch an uncrewed Orion spacecraft to a stable orbit beyond the Moon and bring it back to Earth for a splashdown in the Pacific Ocean.

An open platform for promoting interoperability in solar system sciences

NASA Astrophysics Data System (ADS)

Csillaghy, André; Aboudarham, Jean; Berghmans, David; Jacquey, Christian

2013-04-01

The European coordination project CASSIS is promoting the creation of an integrated data space that will facilitate science across community boundaries in solar system sciences. Many disciplines may need to use the same data set to support scientific research, although the way they are used may depend on the project and on the particular piece of science. Often, access is hindered because of differences in the way the different communities describe, store their data, as well as how they make them accessible. Working towards this goal, we have set up an open collaboration platform, www.explorespace.eu, that can serve as a hub for discovering and developing interoperability resources in the communities involved. The platform is independent of the project and will be maintained well after the end of the funding. As a first step, we have captured the description of services already provided by the community. The openness of the collaboration platform should allow to discuss with all stakeholders ways to make key types of metadata and derived products more complete and coherent and thus more usable across the domain boundaries. Furthermore, software resources and discussions should help facilitating the development of interoperable services. The platform, along with the database of services, address the following questions, which we consider crucial for promoting interoperability: • Current extent of the data space coverage: What part of the common data space is already covered by the existing interoperable services in terms of data access. In other words, what data, from catalogues as well as from raw data, can be reached by an application through standard protocols today? • Needed extension of the data space coverage: What would be needed to extend the data space coverage? In other words, how can the currently accessible data space be extended by adding services? • Missing services: What applications / services are still missing and need to be developed? This is not a trivial question, as the generation of the common data space in itself creates new requirements on overarching applications that might be necessary to provide a unified access to all the services. As an example, one particular aspect discussed in the platform is the design of web services. Applications of today are mainly human centred while interoperability must happen one level below and the back ends (databases) must be generic, i.e. independent from the applications. We intent our effort to provide to developers resources that disentangle user interfaces from data services. Many activities are challenging and we hope they will be discussed on our platform. In particular, the quality of the services, the data space and the needs of interdisciplinary approaches are serious concerns for instruments such as ATST and EST or the ones onboard SDO and, in the future, Solar Orbiter. We believe that our platform might be useful as a kind of guide that would allow groups of not having to reinvent the wheel for each new instrument.

Waveform Developer's Guide for the Integrated Power, Avionics, and Software (iPAS) Space Telecommunications Radio System (STRS) Radio

NASA Technical Reports Server (NTRS)

Shalkhauser, Mary Jo W.; Roche, Rigoberto

2017-01-01

The Space Telecommunications Radio System (STRS) provides a common, consistent framework for software defined radios (SDRs) to abstract the application software from the radio platform hardware. The STRS standard aims to reduce the cost and risk of using complex, configurable and reprogrammable radio systems across NASA missions. To promote the use of the STRS architecture for future NASA advanced exploration missions, NASA Glenn Research Center (GRC) developed an STRS-compliant SDR on a radio platform used by the Advance Exploration System program at the Johnson Space Center (JSC) in their Integrated Power, Avionics, and Software (iPAS) laboratory. The iPAS STRS Radio was implemented on the Reconfigurable, Intelligently-Adaptive Communication System (RIACS) platform, currently being used for radio development at JSC. The platform consists of a Xilinx(Trademark) ML605 Virtex(Trademark)-6 FPGA board, an Analog Devices FMCOMMS1-EBZ RF transceiver board, and an Embedded PC (Axiomtek(Trademark) eBox 620-110-FL) running the Ubuntu 12.4 operating system. The result of this development is a very low cost STRS compliant platform that can be used for waveform developments for multiple applications. The purpose of this document is to describe how to develop a new waveform using the RIACS platform and the Very High Speed Integrated Circuits (VHSIC) Hardware Description Language (VHDL) FPGA wrapper code and the STRS implementation on the Axiomtek processor.

Data analysis and interpretation related to space system/environment interactions at LEO altitude

NASA Technical Reports Server (NTRS)

Raitt, W. John; Schunk, Robert W.

1991-01-01

Several studies made on the interaction of active systems with the LEO space environment experienced from orbital or suborbital platforms are covered. The issue of high voltage space interaction is covered by theoretical modeling studies of the interaction of charged solar cell arrays with the ionospheric plasma. The theoretical studies were complemented by experimental measurements made in a vacuum chamber. The other active system studied was the emission of effluent from a space platform. In one study the emission of plasma into the LEO environment was studied by using initially a 2-D model, and then extending this model to 3-D to correctly take account of plasma motion parallel to the geomagnetic field. The other effluent studies related to the releases of neutral gas from an orbiting platform. One model which was extended and used determined the density, velocity, and energy of both an effluent gas and the ambient upper atmospheric gases over a large volume around the platform. This model was adapted to study both ambient and contaminant distributions around smaller objects in the orbital frame of reference with scale sizes of 1 m. The other effluent studies related to the interaction of the released neutral gas with the ambient ionospheric plasma. An electrostatic model was used to help understand anomalously high plasma densities measured at times in the vicinity of the space shuttle orbiter.

The Method of Multiple Spatial Planning Basic Map

NASA Astrophysics Data System (ADS)

Zhang, C.; Fang, C.

2018-04-01

The "Provincial Space Plan Pilot Program" issued in December 2016 pointed out that the existing space management and control information management platforms of various departments were integrated, and a spatial planning information management platform was established to integrate basic data, target indicators, space coordinates, and technical specifications. The planning and preparation will provide supportive decision support, digital monitoring and evaluation of the implementation of the plan, implementation of various types of investment projects and space management and control departments involved in military construction projects in parallel to approve and approve, and improve the efficiency of administrative approval. The space planning system should be set up to delimit the control limits for the development of production, life and ecological space, and the control of use is implemented. On the one hand, it is necessary to clarify the functional orientation between various kinds of planning space. On the other hand, it is necessary to achieve "multi-compliance" of various space planning. Multiple spatial planning intergration need unified and standard basic map(geographic database and technical specificaton) to division of urban, agricultural, ecological three types of space and provide technical support for the refinement of the space control zoning for the relevant planning. The article analysis the main space datum, the land use classification standards, base map planning, planning basic platform main technical problems. Based on the geographic conditions, the results of the census preparation of spatial planning map, and Heilongjiang, Hainan many rules combined with a pilot application.

Near Field HF Antenna Pattern Measurement Method Using an Antenna Pattern Range

DTIC Science & Technology

2015-12-01

Year 2015 by the Applied Electromagnetics Branch (Code 52250) of the System of Systems (SoS) & Platform Design Division (Code 52200), Space and...Head SoS & Platform Design Division iii EXECUTIVE SUMMARY The Antenna Pattern Range (APR) is an essential measurement facility operated at Space...14 1 INTRODUCTION Accurate characterization of antennas designed to support the warfighter is a critical

Study of thermal management for space platform applications: Unmanned modular thermal management and radiator technologies

NASA Technical Reports Server (NTRS)

Oren, J. A.

1981-01-01

Candidate techniques for thermal management of unmanned modules docked to a large 250 kW platform were evaluated. Both automatically deployed and space constructed radiator systems were studied to identify characteristics and potential problems. Radiator coating requirements and current state-of-the-art were identified. An assessment of the technology needs was made and advancements were recommended.

A novel approach for simulating the optical misalignment caused by satellite platform vibration in the ground test of satellite optical communication systems.

PubMed

Wang, Qiang; Tan, Liying; Ma, Jing; Yu, Siyuan; Jiang, Yijun

2012-01-16

Satellite platform vibration causes the misalignment between incident direction of the beacon and optical axis of the satellite optical communication system, which also leads to the instability of the laser link and reduces the precision of the system. So how to simulate the satellite platform vibration is a very important work in the ground test of satellite optical communication systems. In general, a vibration device is used for simulating the satellite platform vibration, but the simulation effect is not ideal because of the limited randomness. An approach is reasonable, which uses a natural random process for simulating the satellite platform vibration. In this paper, we discuss feasibility of the concept that the effect of angle of arrival fluctuation is taken as an effective simulation of satellite platform vibration in the ground test of the satellite optical communication system. Spectrum characteristic of satellite platform vibration is introduced, referring to the model used by the European Space Agency (ESA) in the SILEX program and that given by National Aeronautics and Space Development Agency (NASDA) of Japan. Spectrum characteristic of angle of arrival fluctuation is analyzed based on the measured data from an 11.16km bi-directional free space laser transmission experiment. Spectrum characteristic of these two effects is compared. The results show that spectra of these two effects have similar variation trend with the variation of frequency and feasibility of the concept is proved by the comparison results. At last the procedure of this method is proposed, which uses the power spectra of angle of arrival fluctuation to simulate that of the satellite platform vibration. The new approach is good for the ground test of satellite optical communication systems.

Space-based sensor management and geostationary satellites tracking

NASA Astrophysics Data System (ADS)

El-Fallah, A.; Zatezalo, A.; Mahler, R.; Mehra, R. K.; Donatelli, D.

2007-04-01

Sensor management for space situational awareness presents a daunting theoretical and practical challenge as it requires the use of multiple types of sensors on a variety of platforms to ensure that the space environment is continuously monitored. We demonstrate a new approach utilizing the Posterior Expected Number of Targets (PENT) as the sensor management objective function, an observation model for a space-based EO/IR sensor platform, and a Probability Hypothesis Density Particle Filter (PHD-PF) tracker. Simulation and results using actual Geostationary Satellites are presented. We also demonstrate enhanced performance by applying the ProgressiveWeighting Correction (PWC) method for regularization in the implementation of the PHD-PF tracker.

KENNEDY SPACE CENTER, FLA. - STS-114 Commander Eileen Collins talks with workers in the Orbiter Processing Facility. She and other crew members are at KSC to become familiar with Shuttle and mission equipment. The mission is Logistics Flight 1, which is scheduled to deliver supplies and equipment plus the external stowage platform to the International Space Station.

NASA Image and Video Library

2004-03-05

KENNEDY SPACE CENTER, FLA. - STS-114 Commander Eileen Collins talks with workers in the Orbiter Processing Facility. She and other crew members are at KSC to become familiar with Shuttle and mission equipment. The mission is Logistics Flight 1, which is scheduled to deliver supplies and equipment plus the external stowage platform to the International Space Station.

Acceleration levels on board the Space Station and a tethered elevator for micro and variable-gravity applications

NASA Technical Reports Server (NTRS)

Lorenzini, E. C.; Cosmo, M.; Vetrella, S.; Moccia, A.

1988-01-01

This paper investigates the dynamics and acceleration levels of a new tethered system for micro and variable-gravity applications. The system consists of two platforms tethered on opposite sides to the Space Station. A fourth platform, the elevator, is placed in between the Space Station and the upper platform. Variable-g levels on board the elevator are obtained by moving this facility along the upper tether, while micro-g experiments are carried out on board the Space Station. By controlling the length of the lower tether the position of the system CM can be maintained on board the Space Station despite variations of the station's distribution of mass. The paper illustrates the mathematical model, the environmental perturbations and the control techniques which have been adopted for the simulation and control of the system dynamics. Two sets of results from two different simulation runs are shown. The first set shows the system dynamics and the acceleration spectra on board the Space Station and the elevator during station-keeping. The second set of results demonstrates the capability of the elevator to attain a preselected g-level.

Project Report: Design and Analysis for the Deep Space Network BWG Type 2 Antenna Feed Platform

NASA Technical Reports Server (NTRS)

Crawford, Andrew

2011-01-01

The following report explains in detail the solid modeling design process and structural analysis of the LNA (Low Noise Amplifier) feed platform to be constructed and installed on the new BWG (Beam Wave Guide) Type-2 tracking antenna in Canberra, Australia, as well as all future similar BWG Type-2 antennas builds. The Deep Space Networks new BWG Type-2 antennas use beam waveguides to funnel and 'extract' the desired signals received from spacecraft, and the feed platform supports and houses the LNA(Low Noise Amplifier) feed-cone and cryogenic cooling equipment used in the signal transmission and receiving process. The mandated design and construction of this platform to be installed on the new tracking antenna will be used and incorporated on all future similar antenna builds.

Circuit design advances for ultra-low power sensing platforms

NASA Astrophysics Data System (ADS)

Wieckowski, Michael; Dreslinski, Ronald G.; Mudge, Trevor; Blaauw, David; Sylvester, Dennis

2010-04-01

This paper explores the recent advances in circuit structures and design methodologies that have enabled ultra-low power sensing platforms and opened up a host of new applications. Central to this theme is the development of Near Threshold Computing (NTC) as a viable design space for low power sensing platforms. In this paradigm, the system's supply voltage is approximately equal to the threshold voltage of its transistors. Operating in this "near-threshold" region provides much of the energy savings previously demonstrated for subthreshold operation while offering more favorable performance and variability characteristics. This makes NTC applicable to a broad range of power-constrained computing segments including energy constrained sensing platforms. This paper explores the barriers to the adoption of NTC and describes current work aimed at overcoming these obstacles in the circuit design space.

Office of Aeronautics and Space Technology preliminary requirements for space science and applications platform studies

NASA Technical Reports Server (NTRS)

1979-01-01

Needs and requirements for a free flying space science and applications platform to host groupings of compatible, extended mission experiments in earth orbit are discussed. A payload model which serves to define a typical set of mission requirements in the form of a descriptive data base is presented along with experiment leval and group level data summarizations and flight schedules. The payload descriptions are grouped by technology into the following categories: communications, materials (long term effect upon), materials technology development, power, sensors, and thermal control.

GeneLab: NASA's Open Access, Collaborative Platform for Systems Biology and Space Medicine

NASA Technical Reports Server (NTRS)

Berrios, Daniel C.; Thompson, Terri G.; Fogle, Homer W.; Rask, Jon C.; Coughlan, Joseph C.

2015-01-01

NASA is investing in GeneLab1 (http:genelab.nasa.gov), a multi-year effort to maximize utilization of the limited resources to conduct biological and medical research in space, principally aboard the International Space Station (ISS). High-throughput genomic, transcriptomic, proteomic or other omics analyses from experiments conducted on the ISS will be stored in the GeneLab Data Systems (GLDS), an open-science information system that will also include a biocomputation platform with collaborative science capabilities, to enable the discovery and validation of molecular networks.

Detail view looking aft along the starboard side of the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail view looking aft along the starboard side of the Orbiter Discovery where the forward section meets the mid-fuselage. Note the head of the jack stand and its mechanism to connect to the one of the forward hoist attach points of the orbiter. Also note the support structure of the service platforms. This view was taken from the service platform in the Orbiter Processing Facility at Kennedy Space Center. - Space Transportation System, Orbiter Discovery (OV-103), Lyndon B. Johnson Space Center, 2101 NASA Parkway, Houston, Harris County, TX

Space transportation node - The Atrium Facility

NASA Technical Reports Server (NTRS)

Kennedy, Kriss J.

1990-01-01

A conceptual design for a space transportation node is presented with a view to the fulfilment of assembly platform support requirements associated with a lunar transportation system. This 'Atrium Facility', which will support lunar base activities before, during, and after the lunar base buildup phase, encompasses a central assembly area surrounded by hangars and workstation platforms; six permanent crewmembers will be supported, as well as four to six transient lunar and Space Shuttle crewmembers. The Atrium Facility dry mass of nearly 320,000 kg excludes cryogenic propellant stowage and the traslunar vehicle envisioned for transportation.

Forecasting Space Weather Hazards for Astronauts in Deep Space

NASA Astrophysics Data System (ADS)

Martens, P. C.

2018-02-01

Deep Space Gateway provides a unique platform to develop, calibrate, and test a space weather forecasting system for interplanetary travel in a real life setting. We will discuss requirements and design of such a system.

Science and Technology Research Directions for the International Space Station

NASA Technical Reports Server (NTRS)

1999-01-01

The International Space Station (ISS) is a unique and unprecedented space research facility. Never before have scientists and engineers had access to such a robust, multidisciplinary, long-duration microgravity laboratory. To date, the research community has enjoyed success aboard such platforms as Skylab, the Space Shuttle, and the Russian Mir space station. However, these platforms were and are limited in ways that the ISS is not. Encompassing four times the volume of Mir, the ISS will support dedicated research facilities for at least a dozen scientific and engineering disciplines. Unlike the Space Shuttle, which must return to Earth after less than three weeks in space, the ISS will accommodate experiments that require many weeks even months to complete. Continual access to a microgravity laboratory will allow selected scientific disciplines to progress at a rate far greater than that obtainable with current space vehicles.

Diagenetic patterns and pore space distribution along a platform to outer-shelf transect (Urgonian limestone, Barremian-Aptian, SE France)

NASA Astrophysics Data System (ADS)

Léonide, Philippe; Fournier, François; Reijmer, John J. G.; Vonhof, Hubert; Borgomano, Jean; Dijk, Jurrien; Rosenthal, Maelle; van Goethem, Manon; Cochard, Jean; Meulenaars, Karlien

2014-06-01

The Urgonian limestones of Late Barremian/Early Aptian from Provence (SE, France) are characterized by the occurrence of microporous limestones at regional scale alternating with tight carbonates. This study, based on petrographical (sediment texture, facies) and diagenetical analyses (cement stratigraphy, porosity and isotope geochemistry) of more than 800 limestone samples provides insight into the parameters controlling the genesis, preservation or occlusion of microporosity along an inner platform to outer shelf transect. The tight and microporous Urgonian limestones from Provence can be grouped into 5 rock-types based on textures, associated depositional environments, porosity and pore-type, being: (1) tight inner-platform: TIP; (2) porous inner platform: PIP; (3) tight outer platform: TOP; (4) porous outer platform: POP and (5) tight outer shelf: TOS. In tight (TIP, TOP and TOS types) limestones intergranular and intragranular pore spaces were entirely occluded by early marine and/or early meteoric cementation, whereas in microporous (PIP, POP) limestones a significant fraction of the intergranular macroporosity was preserved during early and shallow burial diagenesis. Micrite neomorphism (hybrid Ostwald ripening process) occurred during meteoric shallow burial diagenesis in PIP and POP limestones during the regional Durancian Uplift event (Albian-Lower Cenomanian). This process resulted in microporosity enhancement and preservation. Circulation of meteoric fluids during exhumation produces intercrystalline microporosity enhancement and moldic porosity development. The present study documents the important role that both early diagenetic and depositional cycles and long-term tectonic processes have on pore space evolution and distribution in Mesozoic platform carbonates.

Risk-based process safety assessment and control measures design for offshore process facilities.

PubMed

Khan, Faisal I; Sadiq, Rehan; Husain, Tahir

2002-09-02

Process operation is the most hazardous activity next to the transportation and drilling operation on an offshore oil and gas (OOG) platform. Past experiences of onshore and offshore oil and gas activities have revealed that a small mis-happening in the process operation might escalate to a catastrophe. This is of especial concern in the OOG platform due to the limited space and compact geometry of the process area, less ventilation, and difficult escape routes. On an OOG platform, each extra control measure, which is implemented, not only occupies space on the platform and increases congestion but also adds extra load to the platform. Eventualities in the OOG platform process operation can be avoided through incorporating the appropriate control measures at the early design stage. In this paper, the authors describe a methodology for risk-based process safety decision making for OOG activities. The methodology is applied to various offshore process units, that is, the compressor, separators, flash drum and driers of an OOG platform. Based on the risk potential, appropriate safety measures are designed for each unit. This paper also illustrates that implementation of the designed safety measures reduces the high Fatal accident rate (FAR) values to an acceptable level.

Multimodal sensing strategies for detecting transparent barriers indoors from a mobile platform

NASA Astrophysics Data System (ADS)

Acevedo, Isaiah; Kleine, R. Kaleb; Kraus, Dustan; Mascareñas, David

2015-04-01

There is currently an interest in developing mobile sensing platforms that fly indoors. The primary goal for these platforms is to be able to successfully navigate a building under various lighting and environmental conditions. There are numerous research challenges associated with this goal, one of which is the platform's ability to detect and identify the presence of transparent barriers. Transparent barriers could include windows, glass partitions, or skylights. For example, in order to successfully navigate inside of a structure, these platforms will need to sense if a space contains a transparent barrier and whether or not this space can be traversed. This project's focus has been developing a multimodal sensing system that can successfully identify such transparent barriers under various lighting conditions while aboard a mobile platform. Along with detecting transparent barriers, this sensing platform is capable of distinguishing between reflective, opaque, and transparent barriers. It will be critical for this system to be able to identify transparent barriers in real-time in order for the navigation system to maneuver accordingly. The properties associated with the interaction between various frequencies of light and transparent materials were one of the techniques leveraged to solve this problem.

A High-Energy Technology Demonstration Platfom: The First Step in a Stepping Stones Approach to Energy-Rich Space Infrastructures

NASA Technical Reports Server (NTRS)

Carrington, Connie; Day, Greg

2004-01-01

The sun provides an abundant source of energy in space, which can be used to power exploration vehicles and infrastructures that support exploration. A first step in developing and demonstrating the necessary technologies to support solar-powered exploration could be a 100-kWe-class solar-powered platform in Earth orbit. This platform would utilize advanced technologies in solar power collection and generation, power management and distribution, thermal management, and electric propulsion. It would also provide a power-rich free-flying platform to demonstrate in space a portfolio of technology flight experiments. This paper presents a preliminary design concept for a 100-kWe solar-powered satellite with the capability to use high-powered electric propulsion, and to flight-demonstrate a variety of payload experiments.

A COTS RF Optical Software Defined Radio for the Integrated Radio and Optical Communications Test Bed

NASA Technical Reports Server (NTRS)

Nappier, Jennifer M.; Zeleznikar, Daniel J.; Wroblewski, Adam C.; Tokars, Roger P.; Schoenholz, Bryan L.; Lantz, Nicholas C.

2016-01-01

The Integrated Radio and Optical Communications (iROC) project at the National Aeronautics and Space Administration (NASA) is investigating the merits of a hybrid radio frequency (RF) and optical communication system for deep space missions. In an effort to demonstrate the feasibility and advantages of a hybrid RFOptical software defined radio (SDR), a laboratory prototype was assembled from primarily commercial-off-the-shelf (COTS) hardware components. This COTS platform has been used to demonstrate simultaneous transmission of the radio and optical communications waveforms through to the physical layer (telescope and antenna). This paper details the hardware and software used in the platform and various measures of its performance. A laboratory optical receiver platform has also been assembled in order to demonstrate hybrid free space links in combination with the transmitter.

A COTS RF/Optical Software Defined Radio for the Integrated Radio and Optical Communications Test Bed

NASA Technical Reports Server (NTRS)

Nappier, Jennifer M.; Zeleznikar, Daniel J.; Wroblewski, Adam C.; Tokars, Roger P.; Schoenholz, Bryan L.; Lantz, Nicholas C.

2017-01-01

The Integrated Radio and Optical Communications (iROC) project at the National Aeronautics and Space Administration (NASA) is investigating the merits of a hybrid radio frequency (RF) and optical communication system for deep space missions. In an effort to demonstrate the feasibility and advantages of a hybrid RF/Optical software defined radio (SDR), a laboratory prototype was assembled from primarily commercial-off-the-shelf (COTS) hardware components. This COTS platform has been used to demonstrate simultaneous transmission of the radio and optical communications waveforms through to the physical layer (telescope and antenna). This paper details the hardware and software used in the platform and various measures of its performance. A laboratory optical receiver platform has also been assembled in order to demonstrate hybrid free space links in combination with the transmitter.

Preliminary control/structure interaction study of coupled Space Station Freedom/Assembly Work Platform/orbiter

NASA Technical Reports Server (NTRS)

Singh, Sudeep K.; Lindenmoyer, Alan J.

1989-01-01

Results are presented from a preliminary control/structure interaction study of the Space Station, the Assembly Work Platform, and the STS orbiter dynamics coupled with the orbiter and station control systems. The first three Space Station assembly flight configurations and their finite element representations are illustrated. These configurations are compared in terms of control authority in each axis and propellant usage. The control systems design parameters during assembly are computed. Although the rigid body response was acceptable with the orbiter Primary Reaction Control System, the flexible body response showed large structural deflections and loads. It was found that severe control/structure interaction occurred if the stiffness of the Assembly Work Platform was equal to that of the station truss. Also, the response of the orbiter Vernier Reaction Control System to small changes in inertia properties is examined.

Bucket platform cooling scheme and related method

DOEpatents

Abuaf, Nesim; Barb, Kevin Joseph; Chopra, Sanjay; Kercher, David Max; Kellock, Iain Robertson; Lenahan, Dean Thomas; Nellian, Sankar; Starkweather, John Howard; Lupe, Douglas Arthur

2002-01-01

A turbine bucket includes an airfoil extending from a platform, having high and low pressure sides; a wheel mounting portion; a hollow shank portion located radially between the platform and the wheel mounting portion, the platform having an under surface. An impingement cooling plate is located in the hollow shank portion, spaced from the under surface, and the impingement plate is formed with a plurality of impingement cooling holes therein.

Six-degree-of-freedom active vibration isolation using a Stewart platform mechanism

NASA Technical Reports Server (NTRS)

Geng, Zheng; Haynes, Leonard S.

1993-01-01

The design and control problems of a class of multidegree-of-freedom vibration isolation systems (VISs) based on a Stewart platform mechanism are studied. A prototype of a six-degree-of-freedom VIS for precision control of a wide range of space-based structures implemented in Intelligent Automation, Inc. is described. The feasibility of using a Stewart platform to achieve 6-degree-of-freedom vibration control in space applications is shown. A new Terfenol-D actuator characterized by significantly longer stroke than any commercially available Terfenol-D actuator and direct flux and strain sensors integral to the actuator is described.

Booster Engine Service Platforms Delivered to VAB

NASA Image and Video Library

2018-04-17

A new service platform for NASA's Space Launch System booster engines, secured on a flatbed truck, has arrived at the Vehicle Assembly Building (VAB) at the agency's Kennedy Space Center in Florida. It was transported from fabricator Met-Con Inc. in Cocoa, Florida. The platform will be stored in the VAB and used for processing and checkout of the engines for the rocket's twin five-segment solid rocket boosters for Exploration Mission-1 (EM-1). During EM-1, an uncrewed Orion spacecraft will launch on the SLS to a stable orbit beyond the Moon and return to Earth for a splashdown in the Pacific Ocean.

Booster Engine Service Platforms Delivered to VAB

NASA Image and Video Library

2018-04-17

A new service platform for NASA's Space Launch System booster engines has been offloaded from a flatbed truck and is being prepared for the move into the Vehicle Assembly Building (VAB) at the agency's Kennedy Space Center in Florida. The platform was transported from fabricator Met-Con Inc. in Cocoa, Florida. It will be stored in the VAB, and used for processing and checkout of the engines for the rocket's twin five-segment solid rocket boosters for Exploration Mission-1. EM-1 will launch an uncrewed Orion spacecraft to a stable orbit beyond the Moon and bring it back to Earth for a splashdown in the Pacific Ocean.

Booster Engine Service Platforms Delivered to VAB

NASA Image and Video Library

2018-04-17

A new service platform for NASA's Space Launch System booster engines, secured on a flatbed truck, is on its way to the agency's Kennedy Space Center in Florida. It was transported from fabricator Met-Con Inc. in Cocoa, Florida. The platform will be delivered to the Vehicle Assembly Building, where it will be stored and used for processing and checkout of the engines for the rocket's twin five-segment solid rocket boosters for Exploration Mission-1 (EM-1). During EM-1, an uncrewed Orion spacecraft will launch on the SLS to a stable orbit beyond the Moon and return to Earth for a splashdown in the Pacific Ocean.

SLS Booster Engine Service Platforms Delivery

NASA Image and Video Library

2017-07-31

A flatbed truck carrying one of two new service platforms for NASA's Space Launch System booster engines makes its way along the NASA Causeway to the agency's Kennedy Space Center in Florida. The platforms were transported from fabricator Met-Con Inc. in Cocoa, Florida. They will be delivered to the Vehicle Assembly Building, where they will be stored and used for processing and checkout of the engines for the rocket's twin five-segment solid rocket boosters for Exploration Mission-1. EM-1 will launch an uncrewed Orion spacecraft to a stable orbit beyond the Moon and bring it back to Earth for a splashdown in the Pacific Ocean.

Space shuttle main engine high pressure fuel pump aft platform seal cavity flow analysis

NASA Technical Reports Server (NTRS)

Lowry, S. A.; Keeton, L. W.

1987-01-01

A general purpose, three-dimensional computational fluid dynamics code named PHOENICS, developed by CHAM Inc., is used to model the flow in the aft-platform seal cavity in the high pressure fuel pump of the space shuttle main engine. The model is used to predict the temperatures, velocities, and pressures in the cavity for six different sets of boundary conditions. The results are presented as input for further analysis of two known problems in the region, specifically: erratic pressures and temperatures in the adjacent coolant liner cavity and cracks in the blade shanks near the outer diameter of the aft-platform seal.

Innovative lightweight substrate for stable optical benches and mirrors

NASA Astrophysics Data System (ADS)

Rugi Grond, E.; Herren, A.; Mérillat, S.; Fermé, J. J.

2017-11-01

High precision space optics, such as spectrometers, relay optics, and filters, require ultra stable, lightweight platforms. These equipped platforms have on one side to survive the launch loads, on the other side they have to maintain their stability also under the varying thermal loads occurring in space. Typically such platforms have their equipment (prisms, etalons, beam expanders, etc.) mounted by means of classical bonding, hydro-catalytic bonding or optical contacting. Therefore such an optical bench requires to provide an excellent flatness, minimal roughness and is usually made of the same material as the equipment it carries (glass, glass ceramics). For space systems, mass is a big penalty, therefore such optical platforms are in most cases light weighted by means of machining features (i.e. pockets). Besides of being not extremely mass efficient, such pockets reduce the load carrying capability of the base material significantly. The challenge for Oerlikon Space, in this context, was to develop, qualify and deliver such optical benches, providing a substantial mass reduction compared to actual light weighted systems, while maintaining most of the full load carrying capacity of the base material. Additionally such a substrate can find an attractive application for mirror substrates. The results of the first development and of the first test results will be presented.

Quantum Opportunities and Challenges for Fundamental Sciences in Space

NASA Technical Reports Server (NTRS)

Yu, Nan

2012-01-01

Space platforms offer unique environment for and measurements of quantum world and fundamental physics. Quantum technology and measurements enhance measurement capabilities in space and result in greater science returns.

An Overview of Advanced Concepts for Launch

DTIC Science & Technology

2012-02-09

Loads, System. --- Space Platforms Unfeasible. --- Space Elevator Materials, O, µmeteoroids, weather, vibrations.. Asteroid Mining Breakthrough...Unfeasible. --- Space Elevator Materials, O, µmeteoroids, weather, vibrations.. Asteroid Mining Breakthrough Physics No known feasible concepts

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, astronaut Stephen Frick and STS-114 Mission Specialist Wendy Lawrence watch as crew members work with equipment that will be used on the mission. Frick is a tile specialist, who joined the STS-114 crew during equipment familiarization at KSC. STS-114 is classified as Logistics Flight 1 to the International Space Station, delivering new supplies and replacing one of the orbital outpost’s Control Moment Gyroscopes (CMGs). STS-114 will also carry a Raffaello Multi-Purpose Logistics Module and the External Stowage Platform-2. The crew is slated to conduct at least three spacewalks: They will demonstrate repair techniques of the Shuttle’s Thermal Protection System, replace the failed CMG with one delivered by the Shuttle, and install the External Stowage Platform.

NASA Image and Video Library

2004-01-27

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, astronaut Stephen Frick and STS-114 Mission Specialist Wendy Lawrence watch as crew members work with equipment that will be used on the mission. Frick is a tile specialist, who joined the STS-114 crew during equipment familiarization at KSC. STS-114 is classified as Logistics Flight 1 to the International Space Station, delivering new supplies and replacing one of the orbital outpost’s Control Moment Gyroscopes (CMGs). STS-114 will also carry a Raffaello Multi-Purpose Logistics Module and the External Stowage Platform-2. The crew is slated to conduct at least three spacewalks: They will demonstrate repair techniques of the Shuttle’s Thermal Protection System, replace the failed CMG with one delivered by the Shuttle, and install the External Stowage Platform.

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, STS-114 Mission Specialists Andrew Thomas (center) and Soichi Noguchi (right) work with equipment while Mission Specialist Charles Camarda (left) watches. Noguchi is with the Japanese Aerospace Exploration Agency (JAXA). They and other crew members are at KSC for equipment familiarization. STS-114 is classified as Logistics Flight 1 to the International Space Station, delivering new supplies and replacing one of the orbital outpost’s Control Moment Gyroscopes (CMGs). STS-114 will also carry a Raffaello Multi-Purpose Logistics Module and the External Stowage Platform-2. The crew is slated to conduct at least three spacewalks: They will demonstrate repair techniques of the Shuttle’s Thermal Protection System, replace the failed CMG with one delivered by the Shuttle, and install the External Stowage Platform.

NASA Image and Video Library

2004-01-27

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, STS-114 Mission Specialists Andrew Thomas (center) and Soichi Noguchi (right) work with equipment while Mission Specialist Charles Camarda (left) watches. Noguchi is with the Japanese Aerospace Exploration Agency (JAXA). They and other crew members are at KSC for equipment familiarization. STS-114 is classified as Logistics Flight 1 to the International Space Station, delivering new supplies and replacing one of the orbital outpost’s Control Moment Gyroscopes (CMGs). STS-114 will also carry a Raffaello Multi-Purpose Logistics Module and the External Stowage Platform-2. The crew is slated to conduct at least three spacewalks: They will demonstrate repair techniques of the Shuttle’s Thermal Protection System, replace the failed CMG with one delivered by the Shuttle, and install the External Stowage Platform.

KENNEDY SPACE CENTER, FLA. - Dressed in protective suits, STS-114 Mission Specialist Andrew Thomas (left) and Soichi Noguchi, who is with the Japanese Aerospace Exploration Agency (JAXA), handle equipment in the Space Station Processing Facility that will be used on the mission. They and other crew members are at KSC for equipment familiarization. STS-114 is classified as Logistics Flight 1 to the International Space Station, delivering new supplies and replacing one of the orbital outpost’s Control Moment Gyroscopes (CMGs). STS-114 will also carry a Raffaello Multi-Purpose Logistics Module and the External Stowage Platform-2. The crew is slated to conduct at least three spacewalks: They will demonstrate repair techniques of the Shuttle’s Thermal Protection System, replace the failed CMG with one delivered by the Shuttle, and install the External Stowage Platform.

NASA Image and Video Library

2004-01-27

KENNEDY SPACE CENTER, FLA. - Dressed in protective suits, STS-114 Mission Specialist Andrew Thomas (left) and Soichi Noguchi, who is with the Japanese Aerospace Exploration Agency (JAXA), handle equipment in the Space Station Processing Facility that will be used on the mission. They and other crew members are at KSC for equipment familiarization. STS-114 is classified as Logistics Flight 1 to the International Space Station, delivering new supplies and replacing one of the orbital outpost’s Control Moment Gyroscopes (CMGs). STS-114 will also carry a Raffaello Multi-Purpose Logistics Module and the External Stowage Platform-2. The crew is slated to conduct at least three spacewalks: They will demonstrate repair techniques of the Shuttle’s Thermal Protection System, replace the failed CMG with one delivered by the Shuttle, and install the External Stowage Platform.

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, STS-114 Mission Specialist Stephen Robinson (left) looks at an area overhead in the Japanese Experiment Module (JEM). In the center is Jennifer Goldsmith, with United Space Alliance at Johnson Space Center, and at right is Louise Kleba, with USA at KSC. Crew members are at KSC becoming familiar with Shuttle and mission equipment. The mission is Logistics Flight 1, which is scheduled to deliver supplies and equipment plus the external stowage platform to the International Space Station.

NASA Image and Video Library

2004-03-05

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, STS-114 Mission Specialist Stephen Robinson (left) looks at an area overhead in the Japanese Experiment Module (JEM). In the center is Jennifer Goldsmith, with United Space Alliance at Johnson Space Center, and at right is Louise Kleba, with USA at KSC. Crew members are at KSC becoming familiar with Shuttle and mission equipment. The mission is Logistics Flight 1, which is scheduled to deliver supplies and equipment plus the external stowage platform to the International Space Station.

ESPAS: the European e-science platform to access near-Earth space data (Invited)

NASA Astrophysics Data System (ADS)

Belehaki, A.; Hapgood, M. A.; Ritschel, B.; Manola, N.

2013-12-01

The aim of ESPAS platform is to integrate heterogeneous data from the earth's thermosphere, ionosphere, plasmasphere and magnetosphere. ESPAS supports the systematic exploration of multipoint measurements from the near-Earth space through homogenised access to multi-instrument data. It provides access to more than 40 datasets: Cluster, EISCAT, GIRO, DIAS, SWACI, CHAMP, SuperDARN, FPI, magnetometers INGV, SGO, DTU, IMAGE, TGO, IMAGE/RPI, ACE, SOHO, PROBA2, NOAA/POES, etc. The concept of extensibility to new data sets is an important element in the ESPAS architecture. Within the first year of the project, the main components of the system have been developed, namely, the data model, the XML schemas for metadata exchange format, the ontology, the wrapper installed at the data nodes so that the main platform harvest the metadata, the main platform built on the D-NET framework and the GUI with its designed workflows. The first working prototype supports the search for datasets among a selected number of databases (i.e., EDAM, DIAS, Cluster, SWACI data). The next immediate step would be the implementation of search for characteristics within the datasets. For the second release we are planning to deploy tools for conjunctions between ground-space and space-space and for coincidences. For the final phase of the project the ESPAS infrastructure will be extensively tested through the application of several use cases, designed to serve the needs of the wide interdisciplinary users and producers communities, such as the ionospheric, thermospheric, magnetospheric, space weather and space climate communities, the geophysics community, the space communications engineering, HF users, satellite operators, navigation and surveillance systems, and space agencies. The final ESPAS platform is expected to be delivered in 2015. The abstract is submitted on behalf of the ESPAS-FP7EU team (http://www.espas-fp7.eu): Mike Hapgood, Anna Belehaki, Spiros Ventouras, Natalia Manola, Antonis Lebesis, Bruno Zolesi, Tatjana Gerzen, Ingemar Häggström, Anna Charisi, Ivan Galkin, Jurgen Watermann, Matthew Angling, Timo Asikainen, Alan Aylward, Henrike Barkmann, Peter Bergqvist, Andrew Bushell, Fabien Darrouzet, Dimitris Dialetis, Carl-Fredrik Enell, Daniel Heynderickx, Norbert Jakowski, Magnar Johnsen, Jean Lilensten, Ian McCrea, Kalevi Mursula, Bogdan Nicula, Michael Pezzopane, Viviane Pierrard, Bodo Reinisch, Bernd Ritschel, Luca Spogli, Iwona Stanislawska, Claudia Stolle, Eija Tanskanen, Ioanna Tsagouri, Esa Turunen, Thomas Ulich, Matthew Wild, Tim Yeoman

15 CFR 911.8 - Technical requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... PROCEDURES CONCERNING USE OF THE NOAA SPACE-BASED DATA COLLECTION SYSTEMS § 911.8 Technical requirements. (a) All platform operators of the NOAA DCS must use a data collection platform radio set whose technical...

15 CFR 911.8 - Technical requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... PROCEDURES CONCERNING USE OF THE NOAA SPACE-BASED DATA COLLECTION SYSTEMS § 911.8 Technical requirements. (a) All platform operators of the NOAA DCS must use a data collection platform radio set whose technical...

15 CFR 911.8 - Technical requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... PROCEDURES CONCERNING USE OF THE NOAA SPACE-BASED DATA COLLECTION SYSTEMS § 911.8 Technical requirements. (a) All platform operators of the NOAA DCS must use a data collection platform radio set whose technical...

15 CFR 911.8 - Technical requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... PROCEDURES CONCERNING USE OF THE NOAA SPACE-BASED DATA COLLECTION SYSTEMS § 911.8 Technical requirements. (a) All platform operators of the NOAA DCS must use a data collection platform radio set whose technical...

33 CFR 144.10-1 - Lifesaving equipment.

Code of Federal Regulations, 2014 CFR

2014-07-01

...) OUTER CONTINENTAL SHELF ACTIVITIES LIFESAVING APPLIANCES Unmanned Platforms § 144.10-1 Lifesaving... is no available space to keep them on the platform. [CGD 73-177R, 40 FR 8176, Feb. 26, 1975, as...

33 CFR 144.10-1 - Lifesaving equipment.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) OUTER CONTINENTAL SHELF ACTIVITIES LIFESAVING APPLIANCES Unmanned Platforms § 144.10-1 Lifesaving... is no available space to keep them on the platform. [CGD 73-177R, 40 FR 8176, Feb. 26, 1975, as...

33 CFR 144.10-1 - Lifesaving equipment.

Code of Federal Regulations, 2013 CFR

2013-07-01

...) OUTER CONTINENTAL SHELF ACTIVITIES LIFESAVING APPLIANCES Unmanned Platforms § 144.10-1 Lifesaving... is no available space to keep them on the platform. [CGD 73-177R, 40 FR 8176, Feb. 26, 1975, as...

33 CFR 144.10-1 - Lifesaving equipment.

Code of Federal Regulations, 2012 CFR

2012-07-01

...) OUTER CONTINENTAL SHELF ACTIVITIES LIFESAVING APPLIANCES Unmanned Platforms § 144.10-1 Lifesaving... is no available space to keep them on the platform. [CGD 73-177R, 40 FR 8176, Feb. 26, 1975, as...

33 CFR 144.10-1 - Lifesaving equipment.

Code of Federal Regulations, 2011 CFR

2011-07-01

...) OUTER CONTINENTAL SHELF ACTIVITIES LIFESAVING APPLIANCES Unmanned Platforms § 144.10-1 Lifesaving... is no available space to keep them on the platform. [CGD 73-177R, 40 FR 8176, Feb. 26, 1975, as...

15 CFR 911.8 - Technical requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... PROCEDURES CONCERNING USE OF THE NOAA SPACE-BASED DATA COLLECTION SYSTEMS § 911.8 Technical requirements. (a) All platform operators of the NOAA DCS must use a data collection platform radio set whose technical...

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialist Soichi Noguchi arrives at KSC aboard a T-38 jet aircraft. He and other crew members are at the Center for familiarization activities with equipment. The mission is Logistics Flight 1, scheduled to deliver the Multi-Purpose Logistics Module carrying supplies and equipment to the Space Station and the external stowage platform.

NASA Image and Video Library

2004-03-05

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialist Soichi Noguchi arrives at KSC aboard a T-38 jet aircraft. He and other crew members are at the Center for familiarization activities with equipment. The mission is Logistics Flight 1, scheduled to deliver the Multi-Purpose Logistics Module carrying supplies and equipment to the Space Station and the external stowage platform.

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialist Stephen Robinson arrives at KSC aboard a T-38 jet aircraft. He and other crew members are at the Center for familiarization activities with equipment. The mission is Logistics Flight 1, scheduled to deliver the Multi-Purpose Logistics Module carrying supplies and equipment to the Space Station and the external stowage platform.

NASA Image and Video Library

2004-03-05

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialist Stephen Robinson arrives at KSC aboard a T-38 jet aircraft. He and other crew members are at the Center for familiarization activities with equipment. The mission is Logistics Flight 1, scheduled to deliver the Multi-Purpose Logistics Module carrying supplies and equipment to the Space Station and the external stowage platform.

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialist Charles Camarda arrives at KSC aboard a T-38 jet aircraft. He and other crew members are at the Center for familiarization activities with equipment. The mission is Logistics Flight 1, scheduled to deliver the Multi-Purpose Logistics Module carrying supplies and equipment,to the Space Station, and the external stowage platform.

NASA Image and Video Library

2004-03-05

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialist Charles Camarda arrives at KSC aboard a T-38 jet aircraft. He and other crew members are at the Center for familiarization activities with equipment. The mission is Logistics Flight 1, scheduled to deliver the Multi-Purpose Logistics Module carrying supplies and equipment,to the Space Station, and the external stowage platform.

An Approach to Integrate a Space-Time GIS Data Model with High Performance Computers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Dali; Zhao, Ziliang; Shaw, Shih-Lung

2011-01-01

In this paper, we describe an approach to integrate a Space-Time GIS data model on a high performance computing platform. The Space-Time GIS data model has been developed on a desktop computing environment. We use the Space-Time GIS data model to generate GIS module, which organizes a series of remote sensing data. We are in the process of porting the GIS module into an HPC environment, in which the GIS modules handle large dataset directly via parallel file system. Although it is an ongoing project, authors hope this effort can inspire further discussions on the integration of GIS on highmore » performance computing platforms.« less

Trade studies for nuclear space power systems

NASA Technical Reports Server (NTRS)

Smith, John M.; Bents, David J.; Bloomfield, Harvey S.

1991-01-01

As human visions of space applications expand and as we probe further out into the universe, our needs for power will also expand, and missions will evolve which are enabled by nuclear power. A broad spectrum of missions which are enhanced or enabled by nuclear power sources have been defined. These include Earth orbital platforms, deep space platforms, planetary exploration, and terrestrial resource exploration. The recently proposed Space Exploration Initiative (SEI) to the Moon and Mars has more clearly defined these missions and their power requirements. Presented here are results of recent studies of radioisotope and nuclear reactor energy sources, combined with various energy conversion devices for Earth orbital applications, SEI lunar/Mars rovers, surface power, and planetary exploration.

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialist Soichi Noguchi, who is with the Japanese Aerospace and Exploration Agency, looks at the inside of the Japanese Experiment Module (JEM) in the Space Station Processing Facility. He and other crew members are at KSC becoming familiar with Shuttle and mission equipment. The mission is Logistics Flight 1, which is scheduled to deliver supplies and equipment plus the external stowage platform to the International Space Station.

NASA Image and Video Library

2004-03-05

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialist Soichi Noguchi, who is with the Japanese Aerospace and Exploration Agency, looks at the inside of the Japanese Experiment Module (JEM) in the Space Station Processing Facility. He and other crew members are at KSC becoming familiar with Shuttle and mission equipment. The mission is Logistics Flight 1, which is scheduled to deliver supplies and equipment plus the external stowage platform to the International Space Station.

Space construction system analysis study: Project systems and missions descriptions

NASA Technical Reports Server (NTRS)

1979-01-01

Three project systems are defined and summarized. The systems are: (1) a Solar Power Satellite (SPS) Development Flight Test Vehicle configured for fabrication and compatible with solar electric propulsion orbit transfer; (2) an Advanced Communications Platform configured for space fabrication and compatible with low thrust chemical orbit transfer propulsion; and (3) the same Platform, configured to be space erectable but still compatible with low thrust chemical orbit transfer propulsion. These project systems are intended to serve as configuration models for use in detailed analyses of space construction techniques and processes. They represent feasible concepts for real projects; real in the sense that they are realistic contenders on the list of candidate missions currently projected for the national space program. Thus, they represent reasonable configurations upon which to base early studies of alternative space construction processes.

Identification and Characterization of Genes Required for Early Myxococcus xanthus Developmental Gene Expression

PubMed Central

Guo, Dongchuan; Wu, Yun; Kaplan, Heidi B.

2000-01-01

Starvation and cell density regulate the developmental expression of Myxococcus xanthus gene 4521. Three classes of mutants allow expression of this developmental gene during growth on nutrient agar, such that colonies of strains containing a Tn5 lac Ω4521 fusion are Lac+. One class of these mutants inactivates SasN, a negative regulator of 4521 expression; another class activates SasS, a sensor kinase-positive regulator of 4521 expression; and a third class blocks lipopolysaccharide (LPS) O-antigen biosynthesis. To identify additional positive regulators of 4521 expression, 11 Lac− TnV.AS transposon insertion mutants were isolated from a screen of 18,000 Lac+ LPS O-antigen mutants containing Tn5 lac Ω4521 (Tcr). Ten mutations identified genes that could encode positive regulators of 4521 developmental expression based on their ability to abolish 4521 expression during development in the absence of LPS O antigen and in an otherwise wild-type background. Eight of these mutations mapped to the sasB locus, which encodes the known 4521 regulators SasS and SasN. One mapped to sasS, whereas seven identified new genes. Three mutations mapped to a gene encoding an NtrC-like response regulator homologue, designated sasR, and four others mapped to a gene designated sasP. One mutation, designated ssp10, specifically suppressed the LPS O-antigen defect; the ssp10 mutation had no effect on 4521 expression in an otherwise wild-type background but reduced 4521 developmental expression in the absence of LPS O antigen to a level close to that of the parent strain. All of the mutations except those in sasP conferred defects during growth and development. These data indicate that a number of elements are required for 4521 developmental expression and that most of these are necessary for normal growth and fruiting body development. PMID:10913090

Spectral Factorization and Homogenization Methods for Modeling and Control of Flexible Structures.

DTIC Science & Technology

1986-12-15

to the computation of hybrid, state-space modeling of an integrated space platform . Throughout this effort we have focused on the potential for...models can provide an effective tool for analysis of dynamics of vibrations and their effect on small angle motions for complex space platforms . In this... WIX 1 v .41(Ac 0 0o4 1 2.. 9 2% - L .0U V)V14IC Ma a * 9L 0 a soe - a a.. x m c 4. i.! 0~~~I W ** PMiscellaneous Routines• Power Series Expansion

Controls-Structures Interaction (CSI) technology program summary. Earth orbiting platforms program area of the space platforms technology program

NASA Technical Reports Server (NTRS)

Newsom, Jerry R.

1991-01-01

Control-Structures Interaction (CSI) technology embraces the understanding of the interaction between the spacecraft structure and the control system, and the creation and validation of concepts, techniques, and tools, for enabling the interdisciplinary design of an integrated structure and control system, rather than the integration of a structural design and a control system design. The goal of this program is to develop validated CSI technology for integrated design/analysis and qualification of large flexible space systems and precision space structures. A description of the CSI technology program is presented.

A 100 kW-Class Technology Demonstrator for Space Solar Power

NASA Astrophysics Data System (ADS)

Howell, J.; Carrington, C.; Day, G.

2004-12-01

A first step in the development of solar power from space is the flight demonstration of critical technologies. These fundamental technologies include efficient solar power collection and generation, power management and distribution, and thermal management. In addition, the integration and utilization of these technologies into a viable satellite bus could provide an energy-rich platform for a portfolio of payload experiments such as wireless power transmission (WPT). This paper presents the preliminary design of a concept for a 100 kW-class free-flying platform suitable for flight demonstration of Space Solar Power (SSP) technology experiments.

Oblique view of the Orbiter Discovery from an elevated platform ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Oblique view of the Orbiter Discovery from an elevated platform in the Vehicle Assembly Building at NASA's Kennedy Space Center. Note the Forward Reaction Control System (RCS) Module from the forward section and the Orbiter Maneuvering System (OMS)/RCS pods from the aft section have been removed. Ground support equipment called Strongbacks are attached to the payload bay doors and the Flight Deck windows have been covered by ground support equipment. Also note the scale figure standing by the Orbiter. - Space Transportation System, Orbiter Discovery (OV-103), Lyndon B. Johnson Space Center, 2101 NASA Parkway, Houston, Harris County, TX

Identification of Critical Design Points for the EAP of a Space-based Doppler Lidar Wind Sounder

NASA Technical Reports Server (NTRS)

Emmitt, G. D.; Wood, S. A.

1992-01-01

The feasibility of making tropospheric wind measurements with a space-based Doppler lidar was studied by a number of agencies over the past 10-15 years. Currently NASA has a plan to launch such an instrument, the Laser Atmospheric Wind Sounder (LAWS), within the next decade. The design of the LAWS continues to undergo a series of iterations common to most instruments targeted for a space platform. In general, the constraints of available platform power, weight allowance, and project funds continue to change. With these changes the performance and design specifications also must change.

Promoting Learner Autonomy through Schoology M-Learning Platform in an EAP Class at an Indonesian University

ERIC Educational Resources Information Center

Ardi, Priyatno

2017-01-01

The advent of mobile learning platforms and Web 2.0 technologies is believed to provide an autonomous learning space that minimizes the power structure between the teacher and students in Indonesian EFL classes, accommodating the students to display their capacity to navigate their own learning. "Schoology" m-learning platform, a social…

Development of deployable structures for large space platforms. Volume 2: Design development

NASA Technical Reports Server (NTRS)

Greenberg, H. S.

1983-01-01

Design evolution, test article design, test article mass properties, and structural analysis of deployable platform systems are discussed. Orbit transfer vehicle (OTV) hangar development, OTV hangar concept selection, and manned module development are discussed. Deployable platform systems requirements, material data base, technology development needs, concept selection and deployable volume enclosures are also discussed.

Design Analysis of a Space Based Chromotomographic Hyperspectral Imaging Experiment

DTIC Science & Technology

2010-03-01

Tilt Platforms S-340 Platform Recommended Models Mirror Aluminum Aluminum S-340.Ax Invar Zerodur glass S-340.ix Titanium BK7 glass S-340.Tx Steel S-340...composed of a telescope, two grating spectrometers, calibration lamps, and focal plane electronics and cooling system. The telescope is a three mirror ...advanced hyperspectral imager for coastal bathymetry is that the experiment will closely mirror that of the proposed space-based chromotomographic hy

KENNEDY SPACE CENTER, FLA. - Workers, covered in protective clothing and breathing apparatus, continue sandblasting on the Mobile Launcher Platform on Launch Pad 39A to remove corrosion before repainting. Routine maintenance includes sandblasting and repainting as preventive means to minimize corrosion.

NASA Image and Video Library

2003-09-12

KENNEDY SPACE CENTER, FLA. - Workers, covered in protective clothing and breathing apparatus, continue sandblasting on the Mobile Launcher Platform on Launch Pad 39A to remove corrosion before repainting. Routine maintenance includes sandblasting and repainting as preventive means to minimize corrosion.

KENNEDY SPACE CENTER, FLA. - On Launch Pad 39A, clouds of dust float away from the Mobile Launcher Platform, which is undergoing sandblasting to remove corrosion before repainting. Routine maintenance includes sandblasting and repainting as preventive means to minimize corrosion.

NASA Image and Video Library

2003-09-12

KENNEDY SPACE CENTER, FLA. - On Launch Pad 39A, clouds of dust float away from the Mobile Launcher Platform, which is undergoing sandblasting to remove corrosion before repainting. Routine maintenance includes sandblasting and repainting as preventive means to minimize corrosion.

Thinking about Air and Space Power in 2025: Five Guiding Principles

DTIC Science & Technology

2012-06-01

conflicts show the need for thinking about this principle in the design as well as the use of platforms. Any such analysis neces- sitates drawing on all...space and the commonplace employment of medium- and high - altitude drones. The self-deployment of drones and their integra- tion into air traffic will...technical advances will lead to the de- velopment of stratospheric drones ( high - altitude platforms), adding the benefits of increased persistence

Time and Space Partitioning the EagleEye Reference Misson

NASA Astrophysics Data System (ADS)

Bos, Victor; Mendham, Peter; Kauppinen, Panu; Holsti, Niklas; Crespo, Alfons; Masmano, Miguel; de la Puente, Juan A.; Zamorano, Juan

2013-08-01

We discuss experiences gained by porting a Software Validation Facility (SVF) and a satellite Central Software (CSW) to a platform with support for Time and Space Partitioning (TSP). The SVF and CSW are part of the EagleEye Reference mission of the European Space Agency (ESA). As a reference mission, EagleEye is a perfect candidate to evaluate practical aspects of developing satellite CSW for and on TSP platforms. The specific TSP platform we used consists of a simulated LEON3 CPU controlled by the XtratuM separation micro-kernel. On top of this, we run five separate partitions. Each partition runs its own real-time operating system or Ada run-time kernel, which in turn are running the application software of the CSW. We describe issues related to partitioning; inter-partition communication; scheduling; I/O; and fault-detection, isolation, and recovery (FDIR).

Airship platform for high-resolution space technology telescope

NASA Astrophysics Data System (ADS)

Miller, John A.

1995-06-01

This paper sets out to describe the utilization of an unmanned lighter-than-air vehicle as a sub- orbital airborne mission platform for the deployment of space technology telescopes allowing innovative space quality astronomy to be conducted. The paper describes how a low cost airship of relatively simple design can be produced that will be capable of operating in an unmanned remotely piloted mode from a base, fly to a pressure altitude, shut down engines, and operate in a free balloon stage for the period of experimental research. It will be shown that ballooning will allow the platform to be completely free from vibration, and in conjunction with high altitude and polar weather conditions minimize perturbation caused by weather. This paper outlines the technical features of the airship, the projected mission interfaces and the modus operandi of Airship delivery, ground base and missions operations, and final recovery.

Suborbital Platforms as a Tool for a Symbiotic Relationship Between Scientists, Engineers, and Students

NASA Technical Reports Server (NTRS)

Chamberlin, Phillip C.

2011-01-01

Sounding rockets started in-situ space experimentation over 60 years ago with scientific experiments replacing warheads on captured V- 2 German rockets. Prior to this, and still today, suborbital platforms such as airplanes and high-altitude balloons have provided advantageous remote sensing observations advancing many areas of Earth and Space science. There is still a place for first-rate science in both stand-alone missions as well as providing complimentary measurements to the larger orbital missions. Along with the aforementioned science, the cost effectiveness and development times provided by sub-orbital platforms allows for perfect hands-on and first rate educational opportunities for undergraduate and graduate students. This talk will give examples and discuss the mutually beneficial opportunities that scientists and students obtain in development of suborbital missions. Also discussed will be how the next generation of space vehicles should help eliminate the number one obstacle to these programs - launch opportunities.

Space platform expendables resupply concept definition study. Volume 3: Work breakdown structure and work breakdown structure dictionary

NASA Technical Reports Server (NTRS)

1984-01-01

The work breakdown structure (WBS) for the Space Platform Expendables Resupply Concept Definition Study is described. The WBS consists of a list of WBS elements, a dictionary of element definitions, and an element logic diagram. The list and logic diagram identify the interrelationships of the elements. The dictionary defines the types of work that may be represented by or be classified under each specific element. The Space Platform Expendable Resupply WBS was selected mainly to support the program planning, scheduling, and costing performed in the programmatics task (task 3). The WBS is neither a statement-of-work nor a work authorization document. Rather, it is a framework around which to define requirements, plan effort, assign responsibilities, allocate and control resources, and report progress, expenditures, technical performance, and schedule performance. The WBS element definitions are independent of make-or-buy decisions, organizational structure, and activity locations unless exceptions are specifically stated.

Advancing Translational Space Research Through Biospecimen Sharing: Amplified Impact of Studies Utilizing Analogue Space Platforms

NASA Technical Reports Server (NTRS)

Staten, B.; Moyer, E.; Vizir, V.; Gompf, H.; Hoban-Higgins, T.; Lewis, L.; Ronca, A.; Fuller, C. A.

2016-01-01

Biospecimen Sharing Programs (BSPs) have been organized by NASA Ames Research Center since the 1960s with the goal of maximizing utilization and scientific return from rare, complex and costly spaceflight experiments. BSPs involve acquiring otherwise unused biological specimens from primary space research experiments for distribution to secondary experiments. Here we describe a collaboration leveraging Ames expertise in biospecimen sharing to magnify the scientific impact of research informing astronaut health funded by the NASA Human Research Program (HRP) Human Health Countermeasures (HHC) Element. The concept expands biospecimen sharing to one-off ground-based studies utilizing analogue space platforms (e.g., Hindlimb Unloading (HLU), Artificial Gravity) for rodent experiments, thereby significantly broadening the range of research opportunities with translational relevance for protecting human health in space and on Earth.

KSC-98pc1179

NASA Image and Video Library

1998-09-28

KENNEDY SPACE CENTER, FLA. -- At left, the payload canister for Space Shuttle Discovery is lifted from its canister movement vehicle to the top of the Rotating Service Structure on Launch Pad 39-B. Discovery (right), sitting atop the Mobile Launch Platform and next to the Fixed Service Structure (FSS), is scheduled for launch on Oct. 29, 1998, for the STS-95 mission. That mission includes the International Extreme Ultraviolet Hitchhiker (IEH-3), the Hubble Space Telescope Orbital Systems Test Platform, the Spartan solar-observing deployable spacecraft, and the SPACEHAB single module with experiments on space flight and the aging process. At the top of the FSS can be seen the 80-foot lightning mast . The 4-foot-high lightning rod on top helps prevent lightning current from passing directly through the Space Shuttle and the structures on the pad

Applying MDA to SDR for Space to Model Real-time Issues

NASA Technical Reports Server (NTRS)

Blaser, Tammy M.

2007-01-01

NASA space communications systems have the challenge of designing SDRs with highly-constrained Size, Weight and Power (SWaP) resources. A study is being conducted to assess the effectiveness of applying the MDA Platform-Independent Model (PIM) and one or more Platform-Specific Models (PSM) specifically to address NASA space domain real-time issues. This paper will summarize our experiences with applying MDA to SDR for Space to model real-time issues. Real-time issues to be examined, measured, and analyzed are: meeting waveform timing requirements and efficiently applying Real-time Operating System (RTOS) scheduling algorithms, applying safety control measures, and SWaP verification. Real-time waveform algorithms benchmarked with the worst case environment conditions under the heaviest workload will drive the SDR for Space real-time PSM design.

Programmable Logic Device (PLD) Design Description for the Integrated Power, Avionics, and Software (iPAS) Space Telecommunications Radio System (STRS) Radio

NASA Technical Reports Server (NTRS)

Shalkhauser, Mary Jo W.

2017-01-01

The Space Telecommunications Radio System (STRS) provides a common, consistent framework for software defined radios (SDRs) to abstract the application software from the radio platform hardware. The STRS standard aims to reduce the cost and risk of using complex, configurable and reprogrammable radio systems across NASA missions. To promote the use of the STRS architecture for future NASA advanced exploration missions, NASA Glenn Research Center (GRC) developed an STRS compliant SDR on a radio platform used by the Advance Exploration System program at the Johnson Space Center (JSC) in their Integrated Power, Avionics, and Software (iPAS) laboratory. At the conclusion of the development, the software and hardware description language (HDL) code was delivered to JSC for their use in their iPAS test bed to get hands-on experience with the STRS standard, and for development of their own STRS Waveforms on the now STRS compliant platform.The iPAS STRS Radio was implemented on the Reconfigurable, Intelligently-Adaptive Communication System (RIACS) platform, currently being used for radio development at JSC. The platform consists of a Xilinx ML605 Virtex-6 FPGA board, an Analog Devices FMCOMMS1-EBZ RF transceiver board, and an Embedded PC (Axiomtek eBox 620-110-FL) running the Ubuntu 12.4 operating system. Figure 1 shows the RIACS platform hardware. The result of this development is a very low cost STRS compliant platform that can be used for waveform developments for multiple applications.The purpose of this document is to describe the design of the HDL code for the FPGA portion of the iPAS STRS Radio particularly the design of the FPGA wrapper and the test waveform.

Tethered nuclear power for the Space Station

NASA Technical Reports Server (NTRS)

Bents, D. J.

1985-01-01

A nuclear space power system the SP-100 is being developed for future missions where large amounts of electrical power will be required. Although it is primarily intended for unmanned spacecraft, it can be adapted to a manned space platform by tethering it above the station through an electrical transmission line which isolates the reactor far away from the inhabited platform and conveys its power back to where it is needed. The transmission line, used in conjunction with an instrument rate shield, attenuates reactor radiation in the vicinity of the space station to less than one-one hundredth of the natural background which is already there. This combination of shielding and distance attenuation is less than one-tenth the mass of boom-mounted or onboard man-rated shields that are required when the reactor is mounted nearby. This paper describes how connection is made to the platform (configuration, operational requirements) and introduces a new element the coaxial transmission tube which enables efficient transmission of electrical power through long tethers in space. Design methodology for transmission tubes and tube arrays is discussed. An example conceptual design is presented that shows SP-100 at three power levels 100 kWe, 300 kWe, and 1000 kWe connected to space station via a 2 km HVDC transmission line/tether. Power system performance, mass, and radiation hazard are estimated with impacts on space station architecture and operation.

Tethered nuclear power for the space station

NASA Technical Reports Server (NTRS)

Bents, D. J.

1985-01-01

A nuclear space power system the SP-100 is being developed for future missions where large amounts of electrical power will be required. Although it is primarily intended for unmanned spacecraft, it can be adapted to a manned space platform by tethering it above the station through an electrical transmission line which isolates the reactor far away from the inhabited platform and conveys its power back to where it is needed. The transmission line, used in conjunction with an instrument rate shield, attenuates reactor radiation in the vicinity of the space station to less than one-one hundredth of the natural background which is already there. This combination of shielding and distance attenuation is less than one-tenth the mass of boom-mounted or onboard man-rated shields that are required when the reactor is mounted nearby. This paper describes how connection is made to the platform (configuration, operational requirements) and introduces a new element the coaxial transmission tube which enables efficient transmission of electrical power through long tethers in space. Design methodology for transmission tubes and tube arrays is discussed. An example conceptual design is presented that shows SP-100 at three power levels 100 kWe, 300 kWe, and 1000 kWe connected to space station via a 2 km HVDC transmission line/tether. Power system performance, mass, and radiation hazard are estimated with impacts on space station architecture and operation.

Future Standardization of Space Telecommunications Radio System with Core Flight System

NASA Technical Reports Server (NTRS)

Briones, Janette C.; Hickey, Joseph P.; Roche, Rigoberto; Handler, Louis M.; Hall, Charles S.

2016-01-01

NASA Glenn Research Center (GRC) is integrating the NASA Space Telecommunications Radio System (STRS) Standard with the Core Flight System (cFS), an avionics software operating environment. The STRS standard provides a common, consistent framework to develop, qualify, operate and maintain complex, reconfigurable and reprogrammable radio systems. The cFS is a flexible, open architecture that features a plugand- play software executive called the Core Flight Executive (cFE), a reusable library of software components for flight and space missions and an integrated tool suite. Together, STRS and cFS create a development environment that allows for STRS compliant applications to reference the STRS application programmer interfaces (APIs) that use the cFS infrastructure. These APIs are used to standardize the communication protocols on NASAs space SDRs. The cFS-STRS Operating Environment (OE) is a portable cFS library, which adds the ability to run STRS applications on existing cFS platforms. The purpose of this paper is to discuss the cFS-STRS OE prototype, preliminary experimental results performed using the Advanced Space Radio Platform (ASRP), the GRC S- band Ground Station and the SCaN (Space Communication and Navigation) Testbed currently flying onboard the International Space Station (ISS). Additionally, this paper presents a demonstration of the Consultative Committee for Space Data Systems (CCSDS) Spacecraft Onboard Interface Services (SOIS) using electronic data sheets (EDS) inside cFE. This configuration allows for the data sheets to specify binary formats for data exchange between STRS applications. The integration of STRS with cFS leverages mission-proven platform functions and mitigates barriers to integration with future missions. This reduces flight software development time and the costs of software-defined radio (SDR) platforms. Furthermore, the combined benefits of STRS standardization with the flexibility of cFS provide an effective, reliable and modular framework to minimize software development efforts for spaceflight missions.

Booster Engine Service Platforms Delivered to VAB

NASA Image and Video Library

2018-04-17

A new service platform for NASA's Space Launch System booster engines, secured on a flatbed truck, is on its way to the Vehicle Assembly Building (VAB), in view in the distance, at the agency's Kennedy Space Center in Florida. It was transported from fabricator Met-Con Inc. in Cocoa, Florida. The platform will be delivered to the VAB, where it will be stored and used for processing and checkout of the engines for the rocket's twin five-segment solid rocket boosters for Exploration Mission-1 (EM-1). During EM-1, an uncrewed Orion spacecraft will launch on the SLS to a stable orbit beyond the Moon and return to Earth for a splashdown in the Pacific Ocean.

KENNEDY SPACE CENTER, FLA. - This bird's-eye view of a high bay in the Orbiter Processing Facility (OPF) shows the open payload bay of Space Shuttle Discovery surrounded by the standard platforms and equipment required to process a Space Shuttle orbiter. The high bay is 197 feet (60 meters) long, 150 feet (46 meters) wide, 95 feet (29 meters) high, and encompasses a 29,000-square-foot (2,694-meter) area. The 30-ton (27-metric-ton) bridge crane (yellow device, right) has a hook height of approximately 66 feet (20 meters). Platforms, a main access bridge, and two rolling bridges with trucks provide access to various parts of the orbiter. In addition to routine servicing and checkout, the inspections and modifications made to enhance Discovery's performance and upgrade its systems were performed in the OPF during its recently completed Orbiter Major Modification (OMM) period.

NASA Image and Video Library

2003-09-02

KENNEDY SPACE CENTER, FLA. - This bird's-eye view of a high bay in the Orbiter Processing Facility (OPF) shows the open payload bay of Space Shuttle Discovery surrounded by the standard platforms and equipment required to process a Space Shuttle orbiter. The high bay is 197 feet (60 meters) long, 150 feet (46 meters) wide, 95 feet (29 meters) high, and encompasses a 29,000-square-foot (2,694-meter) area. The 30-ton (27-metric-ton) bridge crane (yellow device, right) has a hook height of approximately 66 feet (20 meters). Platforms, a main access bridge, and two rolling bridges with trucks provide access to various parts of the orbiter. In addition to routine servicing and checkout, the inspections and modifications made to enhance Discovery's performance and upgrade its systems were performed in the OPF during its recently completed Orbiter Major Modification (OMM) period.

Integrated Modular Avionics for Spacecraft: Earth Observation Use Case Demonstrator

NASA Astrophysics Data System (ADS)

Deredempt, Marie-Helene; Rossignol, Alain; Hyounet, Philippe

2013-08-01

Integrated Modular Avionics (IMA) for Space, as European Space Agency initiative, aimed to make applicable to space domain the time and space partitioning concepts and particularly the ARINC 653 standard [1][2]. Expected benefits of such an approach are development flexibility, capability to provide differential V&V for different criticality level functionalities and to integrate late or In-Orbit delivery. This development flexibility could improve software subcontracting, industrial organization and software reuse. Time and space partitioning technique facilitates integration of software functions as black boxes and integration of decentralized function such as star tracker in On Board Computer to save mass and power by limiting electronics resources. In aeronautical domain, Integrated Modular Avionics architecture is based on a network of LRU (Line Replaceable Unit) interconnected by AFDX (Avionic Full DupleX). Time and Space partitioning concept is applicable to LRU and provides independent partitions which inter communicate using ARINC 653 communication ports. Using End System (LRU component) intercommunication between LRU is managed in the same way than intercommunication between partitions in LRU. In such architecture an application developed using only communication port can be integrated in an LRU or another one without impacting the global architecture. In space domain, a redundant On Board Computer controls (ground monitoring TM) and manages the platform (ground command TC) in terms of power, solar array deployment, attitude, orbit, thermal, maintenance, failure detection and recovery isolation. In addition, Payload units and platform units such as RIU, PCDU, AOCS units (Star tracker, Reaction wheels) are considered in this architecture. Interfaces are mainly realized through MIL-STD-1553B busses and SpaceWire and this could be considered as the main constraint for IMA implementation in space domain. During the first phase of IMA SP project, ARINC653 impact was analyzed. Requirements and architecture for space domain were defined [3][4] and System Executive platforms (based on Xtratum, Pike OS, and AIR) were developed with RTEMS as Guest OS. This paper focuses on the demonstrator developed by Astrium as part of IMA SP project. This demonstrator has the objective to confirm operational software partitioning feasibility above Xtratum System Executive Platform with acceptable CPU overhead.

Development of deployable structures for large space platform systems, part 1

NASA Technical Reports Server (NTRS)

Cox, R. L.; Nelson, R. A.

1982-01-01

Eight deployable platform design objectives were established: autodeploy/retract; fully integrated utilities; configuration variability; versatile payload and subsystem interfaces; structural and packing efficiency; 1986 technology readiness; minimum EVA/RMS; and Shuttle operational compatibility.

33 CFR 155.400 - Platform machinery space drainage on oceangoing fixed and floating drilling rigs and other...

Code of Federal Regulations, 2010 CFR

2010-07-01

... Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS Vessel Equipment § 155.400 Platform...

Earth Science Geostationary Platform Technology

NASA Technical Reports Server (NTRS)

Wright, Robert L. (Editor); Campbell, Thomas G. (Editor)

1989-01-01

The objective of the workshop was to address problems in science and in four technology areas (large space antenna technology, microwave sensor technology, electromagnetics-phased array adaptive systems technology, and optical metrology technology) related to Earth Science Geostationary Platform missions.

Astrobee: A New Platform for Free-Flying Robotics on the International Space Station

NASA Technical Reports Server (NTRS)

Smith, Trey; Barlow, Jonathan; Bualat, Maria; Fong, Terrence; Provencher, Christopher; Sanchez, Hugo; Smith, Ernest

2016-01-01

The Astrobees are next-generation free-flying robots that will operate in the interior of the International Space Station (ISS). Their primary purpose is to provide a flexible platform for research on zero-g freeflying robotics, with the ability to carry a wide variety of future research payloads and guest science software. They will also serve utility functions: as free-flying cameras to record video of astronaut activities, and as mobile sensor platforms to conduct surveys of the ISS. The Astrobee system includes two robots, a docking station, and a ground data system (GDS). It is developed by the Human Exploration Telerobotics 2 (HET-2) Project, which began in Oct. 2014, and will deliver the Astrobees for launch to ISS in 2017. This paper covers selected aspects of the Astrobee design, focusing on capabilities relevant to potential users of the platform.

Development of deployable structures for large space platform systems, volume 1

NASA Technical Reports Server (NTRS)

1982-01-01

Generic deployable spacecraft configurations and deployable platform systems concepts were identified. Sizing, building block concepts, orbiter packaging, thermal analysis, cost analysis, and mass properties analysis as related to platform systems integration are considered. Technology needs are examined and the major criteria used in concept selection are delineated. Requirements for deployable habitat modules, tunnels, and OTV hangars are considered.

Hardware-in-the-Loop Power Extraction Using Different Real-Time Platforms (PREPRINT)

DTIC Science & Technology

2008-07-01

engine controller ( FADEC ). Incorporating various transient subsystem level models into a complex modeling tool can be a challenging process when each...used can also be modified or replaced as appropriate. In its current configuration, the generic turbine engine model’s FADEC runs primarily on a...simulation in real-time, two platforms were tested: dSPACE and National Instruments’ (NI) LabVIEW Real-Time. For both dSPACE and NI, the engine and FADEC

Modal Analysis of Space-rocket Equipment Components

NASA Astrophysics Data System (ADS)

Igolkin, A. A.; Safin, A. I.; Prokofiev, A. B.

2018-01-01

In order to prevent vibration damage an analysis of natural frequencies and mode shapes of elements of rocket and space technology should be developed. This paper discusses technique of modal analysis on the example of the carrier platform. Modal analysis was performed by using mathematical modeling and laser vibrometer. Experimental data was clarified by using Test.Lab software. As a result of modal analysis amplitude-frequency response of carrier platform was obtained and the parameters of the elasticity was clarified.

A Sub-Orbital Platform for Flight Tests of Small Space Capsules

NASA Astrophysics Data System (ADS)

Pereira, P. Moraes A. L., Jr.; Silva, C. R.; Villas Bôas, D. J.; Corrêa, F., Jr.; Miyoshi, J. H.; Loures da Costa, L. E.

2002-01-01

In the development of a small recoverable space capsule, flight tests using sub-orbital rockets are considered. For this test series, a platform for aerodynamic and thermal measurements as also for qualification tests of onboard sub-systems and equipment was specified and is actually under development. This platform, known as SARA Suborbital, is specified to withstand a sub-orbital flight with the high performance sounding rocket VS40 and to be recovered at the sea. To perform the testing program, a flight trajectory with adequate aeroballistic parameters, as for instance high velocities in dense atmosphere and average re-entry velocity, is considered. The testing program includes measurements of aerodynamic pressures and thermal characteristics, three- axis acceleration, acoustic pressure level inside the platform and vibration environment. Beside this, tests to characterise the performance of the data acquisition and transmission system, the micro-gravity environment and to qualify the recovery system will be carried out. During the return flight, the dynamics of parachutes deployment and platform water impact, as also rescue procedures will also be observed. The present article shows the concept of the platform, describes in detail the experiments, and concludes with a discussion on the flight trajectory and recovery procedure.

Resilient and Corrosion-proof Rolling Element Bearings Made from Ni-ti Alloys for Aerospace Mechanism Applications and the Ultimate Space Technology Development Platform

NASA Technical Reports Server (NTRS)

Dellacorte, Christopher

2014-01-01

The International Space Station provides a unique microgravity laboratory environment for research. The ISS also serves as an effective platform for the development of technologies and engineered solutions related to living and working in space. The space environment also challenges our capabilities related to lubrication and tribology. In this seminar, Dr. DellaCorte will review the basics of space mechanism tribology and the challenges of providing good lubrication and long-life in the harsh space environment. He will also discuss recent tribological challenges associated with the Solar Alpha Rotary Joint (SARJ) bearings and life support hardware that must operate under severe conditions that are literally out of this world. Each tribology challenge is unique and their solutions often result in new technologies that benefit the tribology community everywhere, even back on Earth

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialist Soichi Noguchi, with the Japanese Aerospace Exploration Agency (JAXA), handles equipment that will be used on the mission. He and other crew members are at KSC for equipment familiarization. STS-114 is classified as Logistics Flight 1 to the International Space Station, delivering new supplies and replacing one of the orbital outpost’s Control Moment Gyroscopes (CMGs). STS-114 will also carry a Raffaello Multi-Purpose Logistics Module and the External Stowage Platform-2. The crew is slated to conduct at least three spacewalks: They will demonstrate repair techniques of the Shuttle’s Thermal Protection System, replace the failed CMG with one delivered by the Shuttle, and install the External Stowage Platform.

NASA Image and Video Library

2004-01-27

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialist Soichi Noguchi, with the Japanese Aerospace Exploration Agency (JAXA), handles equipment that will be used on the mission. He and other crew members are at KSC for equipment familiarization. STS-114 is classified as Logistics Flight 1 to the International Space Station, delivering new supplies and replacing one of the orbital outpost’s Control Moment Gyroscopes (CMGs). STS-114 will also carry a Raffaello Multi-Purpose Logistics Module and the External Stowage Platform-2. The crew is slated to conduct at least three spacewalks: They will demonstrate repair techniques of the Shuttle’s Thermal Protection System, replace the failed CMG with one delivered by the Shuttle, and install the External Stowage Platform.

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialist Charles Camarda (left) watches as Mission Specialist Andrew Thomas manipulates equipment that will be used on the mission. Crew members are at KSC for equipment familiarization. STS-114 is classified as Logistics Flight 1 to the International Space Station, delivering new supplies and replacing one of the orbital outpost’s Control Moment Gyroscopes (CMGs). STS-114 will also carry a Raffaello Multi-Purpose Logistics Module and the External Stowage Platform-2. The crew is slated to conduct at least three spacewalks: They will demonstrate repair techniques of the Shuttle’s Thermal Protection System, replace the failed CMG with one delivered by the Shuttle, and install the External Stowage Platform.

NASA Image and Video Library

2004-01-27

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialist Charles Camarda (left) watches as Mission Specialist Andrew Thomas manipulates equipment that will be used on the mission. Crew members are at KSC for equipment familiarization. STS-114 is classified as Logistics Flight 1 to the International Space Station, delivering new supplies and replacing one of the orbital outpost’s Control Moment Gyroscopes (CMGs). STS-114 will also carry a Raffaello Multi-Purpose Logistics Module and the External Stowage Platform-2. The crew is slated to conduct at least three spacewalks: They will demonstrate repair techniques of the Shuttle’s Thermal Protection System, replace the failed CMG with one delivered by the Shuttle, and install the External Stowage Platform.

Sub-Audible Speech Recognition Based upon Electromyographic Signals

NASA Technical Reports Server (NTRS)

Jorgensen, Charles C. (Inventor); Agabon, Shane T. (Inventor); Lee, Diana D. (Inventor)

2012-01-01

Method and system for processing and identifying a sub-audible signal formed by a source of sub-audible sounds. Sequences of samples of sub-audible sound patterns ("SASPs") for known words/phrases in a selected database are received for overlapping time intervals, and Signal Processing Transforms ("SPTs") are formed for each sample, as part of a matrix of entry values. The matrix is decomposed into contiguous, non-overlapping two-dimensional cells of entries, and neural net analysis is applied to estimate reference sets of weight coefficients that provide sums with optimal matches to reference sets of values. The reference sets of weight coefficients are used to determine a correspondence between a new (unknown) word/phrase and a word/phrase in the database.

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialist Soichi Noguchi is happy to be back at KSC after arriving aboard a T-38 jet aircraft. He and other crew members are at the Center for familiarization activities with equipment. The mission is Logistics Flight 1, scheduled to deliver the Multi-Purpose Logistics Module carrying supplies and equipment to the Space Station and the external stowage platform.

NASA Image and Video Library

2004-03-05

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialist Soichi Noguchi is happy to be back at KSC after arriving aboard a T-38 jet aircraft. He and other crew members are at the Center for familiarization activities with equipment. The mission is Logistics Flight 1, scheduled to deliver the Multi-Purpose Logistics Module carrying supplies and equipment to the Space Station and the external stowage platform.

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Commander Eileen Collins is pleased to be back at KSC after arriving aboard a T-38 jet aircraft. She and other crew members are at the Center for familiarization activities with equipment. The mission is Logistics Flight 1, scheduled to deliver to the Space Station the external stowage platform and the Multi-Purpose Logistics Module with supplies and equipment.

NASA Image and Video Library

2004-03-05

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Commander Eileen Collins is pleased to be back at KSC after arriving aboard a T-38 jet aircraft. She and other crew members are at the Center for familiarization activities with equipment. The mission is Logistics Flight 1, scheduled to deliver to the Space Station the external stowage platform and the Multi-Purpose Logistics Module with supplies and equipment.

KENNEDY SPACE CENTER, FLA. - STS-114 Pilot Jim Kelly is pleased to be back at KSC after arriving aboard a T-38 jet aircraft. He and other crew members are at the Center for familiarization activities with equipment. The mission is Logistics Flight 1, scheduled to deliver the Multi-Purpose Logistics Module carrying supplies and equipment to the Space Station and the external stowage platform.

NASA Image and Video Library

2004-03-05

KENNEDY SPACE CENTER, FLA. - STS-114 Pilot Jim Kelly is pleased to be back at KSC after arriving aboard a T-38 jet aircraft. He and other crew members are at the Center for familiarization activities with equipment. The mission is Logistics Flight 1, scheduled to deliver the Multi-Purpose Logistics Module carrying supplies and equipment to the Space Station and the external stowage platform.

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialist Andrew Thomas is pleased to be back at KSC after arriving aboard a T-38 jet aircraft. He and other crew members are at the Center for familiarization activities with equipment. The mission is Logistics Flight 1, scheduled to deliver to the Space Station the external stowage platform and the Multi-Purpose Logistics Module with supplies and equipment.

NASA Image and Video Library

2004-03-05

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialist Andrew Thomas is pleased to be back at KSC after arriving aboard a T-38 jet aircraft. He and other crew members are at the Center for familiarization activities with equipment. The mission is Logistics Flight 1, scheduled to deliver to the Space Station the external stowage platform and the Multi-Purpose Logistics Module with supplies and equipment.

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialist Wendy Lawrence is pleased to be back at KSC after arriving aboard a T-38 jet aircraft. She and other crew members are at the Center for familiarization activities with equipment. The mission is Logistics Flight 1, scheduled to deliver the Multi-Purpose Logistics Module carrying supplies and equipment to the Space Station and the external stowage platform.

NASA Image and Video Library

2004-03-05

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialist Wendy Lawrence is pleased to be back at KSC after arriving aboard a T-38 jet aircraft. She and other crew members are at the Center for familiarization activities with equipment. The mission is Logistics Flight 1, scheduled to deliver the Multi-Purpose Logistics Module carrying supplies and equipment to the Space Station and the external stowage platform.

Remote surface inspection system. [of large space platforms

NASA Technical Reports Server (NTRS)

Hayati, Samad; Balaram, J.; Seraji, Homayoun; Kim, Won S.; Tso, Kam S.

1993-01-01

This paper reports on an on-going research and development effort in remote surface inspection of space platforms such as the Space Station Freedom (SSF). It describes the space environment and identifies the types of damage for which to search. This paper provides an overview of the Remote Surface Inspection System that was developed to conduct proof-of-concept demonstrations and to perform experiments in a laboratory environment. Specifically, the paper describes three technology areas: (1) manipulator control for sensor placement; (2) automated non-contact inspection to detect and classify flaws; and (3) an operator interface to command the system interactively and receive raw or processed sensor data. Initial findings for the automated and human visual inspection tests are reported.

ISS As A National Lab

NASA Image and Video Library

2017-07-17

In an effort to expand the research opportunities of this unparalleled platform, the International Space Station was designated as a U.S. National Laboratory in 2005 by Congress, enabling space research and development access to a broad range of commercial, academic, and government users. Now, this unique microgravity research platform is available to U.S. researchers from small companies, research institutions, Fortune 500 companies, government agencies, and others, all interested in leveraging microgravity to solve complex problems on Earth. Get more research news and updates on Twitter at: https://twitter.com/ISS_Research HD download link: https://archive.org/details/jsc2017m000681_ISS As A National Lab _______________________________________ FOLLOW THE SPACE STATION! Twitter: https://twitter.com/Space_Station Facebook: https://www.facebook.com/ISS Instagram: https://instagram.com/iss/

An Investigation of State Educational Twitter Hashtags (SETHS) as Affinity Spaces

ERIC Educational Resources Information Center

Rosenberg, Joshua M.; Greenhalgh, Spencer P.; Koehler, Matthew J.; Hamilton, Erica R.; Akcaoglu, Mete

2016-01-01

Affinity spaces are digital or physical spaces in which participants interact with one another around content of shared interest and through a common portal (or platform). Among teachers, some of the largest affinity spaces may be those organized around hashtags on Twitter: These spaces are public, largely unmoderated, and thriving, yet very…

Space Situational Awareness Data Processing Scalability Utilizing Google Cloud Services

NASA Astrophysics Data System (ADS)

Greenly, D.; Duncan, M.; Wysack, J.; Flores, F.

Space Situational Awareness (SSA) is a fundamental and critical component of current space operations. The term SSA encompasses the awareness, understanding and predictability of all objects in space. As the population of orbital space objects and debris increases, the number of collision avoidance maneuvers grows and prompts the need for accurate and timely process measures. The SSA mission continually evolves to near real-time assessment and analysis demanding the need for higher processing capabilities. By conventional methods, meeting these demands requires the integration of new hardware to keep pace with the growing complexity of maneuver planning algorithms. SpaceNav has implemented a highly scalable architecture that will track satellites and debris by utilizing powerful virtual machines on the Google Cloud Platform. SpaceNav algorithms for processing CDMs outpace conventional means. A robust processing environment for tracking data, collision avoidance maneuvers and various other aspects of SSA can be created and deleted on demand. Migrating SpaceNav tools and algorithms into the Google Cloud Platform will be discussed and the trials and tribulations involved. Information will be shared on how and why certain cloud products were used as well as integration techniques that were implemented. Key items to be presented are: 1.Scientific algorithms and SpaceNav tools integrated into a scalable architecture a) Maneuver Planning b) Parallel Processing c) Monte Carlo Simulations d) Optimization Algorithms e) SW Application Development/Integration into the Google Cloud Platform 2. Compute Engine Processing a) Application Engine Automated Processing b) Performance testing and Performance Scalability c) Cloud MySQL databases and Database Scalability d) Cloud Data Storage e) Redundancy and Availability

Materials experiment carrier concepts definition study. Volume 1: Executive summary, part 2

NASA Technical Reports Server (NTRS)

1981-01-01

The materials experiment carrier (MEC) is an optimized carrier for near term and advanced materials processing in space (MPS) research and commercial payloads. When coupled with the space platform (SP), the MEC can provide the extended duration, high power and low acceleration environment the MPS payload typically requires. The lowest cost, technically reasonable first step MEC that meets the MPS program missions objectives with minimum programmatic risks is defined. The effectiveness of the initial MEC/space platform idea for accommodating high priority, multidiscipline, R&D and commercial MPS payloads, and conducting MPS payload oprations at affordable funding and acceptable productivity levels is demonstrated.

Multidisciplinary optimization of a controlled space structure using 150 design variables

NASA Technical Reports Server (NTRS)

James, Benjamin B.

1992-01-01

A general optimization-based method for the design of large space platforms through integration of the disciplines of structural dynamics and control is presented. The method uses the global sensitivity equations approach and is especially appropriate for preliminary design problems in which the structural and control analyses are tightly coupled. The method is capable of coordinating general purpose structural analysis, multivariable control, and optimization codes, and thus, can be adapted to a variety of controls-structures integrated design projects. The method is used to minimize the total weight of a space platform while maintaining a specified vibration decay rate after slewing maneuvers.

MSG: Microgravity Science Glovebox

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baugher, C.R.; Ramachandran, N.; Roark, W.

1996-12-31

The capabilities of the Space Station glovebox facility is described. Tentatively scheduled to be launched in 1999, this facility called the Microgravity Sciences Glovebox (MSG), will provide a robust and sophisticated platform for doing microgravity experiments on the Space Station. It will provide an environment not only for testing and evaluating experiment concepts, but also serve as a platform for doing fairly comprehensive science investigations. Its design has evolved substantially from the middeck glovebox, now flown on Space Shuttle missions, not only in increased experiment volume but also in significant capability enhancements. The system concept, functionality and architecture are discussedmore » along with technical information that will benefit potential science investigators.« less

Specification Patent Management for Web Application Platform Ecosystem

NASA Astrophysics Data System (ADS)

Fukami, Yoshiaki; Isshiki, Masao; Takeda, Hideaki; Ohmukai, Ikki; Kokuryo, Jiro

Diversified usage of web applications has encouraged disintegration of web platform into management of identification and applications. Users make use of various kinds of data linked to their identity with multiple applications on certain social web platforms such as Facebook or MySpace. There has emerged competition among web application platforms. Platformers can design relationship with developers by controlling patent of their own specification and adopt open technologies developed external organizations. Platformers choose a way to open according to feature of the specification and their position. Patent management of specification come to be a key success factor to build competitive web application platforms. Each way to attract external developers such as standardization, open source has not discussed and analyzed all together.

Fire Protection Jacket

NASA Technical Reports Server (NTRS)

1991-01-01

NERAC, Inc., Tolland, CT, aided Paul Monroe Engineering, Orange, CA, in the development of their PC1200 Series Fire Protection Jacket that protects the oil conduit system on an offshore drilling platform from the intense hydrocarbon fires that cause buckling and could cause structural failure of the platform. The flame-proof jacketing, which can withstand temperatures of 2000 degrees Fahrenheit for four hours or more, was developed from a combination of ceramic cloth (similar to the ceramic in Space Shuttle tiles), and laminates used in space suits.

Modular design attitude control system

NASA Technical Reports Server (NTRS)

Chichester, F. D.

1982-01-01

A hybrid multilevel linear quadratic regulator (ML-LQR) approach was developed and applied to the attitude control of models of the rotational dynamics of a prototype flexible spacecraft and of a typical space platform. Three axis rigid body flexible suspension models were developed for both the spacecraft and the space platform utilizing augmented body methods. Models of the spacecraft with hybrid ML-LQR attitude control and with LQR attitude control were simulated and their response with the two different types of control were compared.

Ionospheric Profiles from Ultraviolet Remote Sensing

DTIC Science & Technology

1998-01-01

remote sensing of the ionosphere from orbiting space platforms. Remote sensing of the nighttime ionosphere is a relatively straightforward process due to the absence of the complications brought about by daytime solar radiation. Further, during the nighttime hours, the O(+)-H(+) transition level in both the mid- and low-latitude ionospheres lies around 750 km, which is within the range of accuracy of the path matrix inversion. The intensity of the O(+)-e(-) recombination radiation as observed from orbiting space platforms can now be used to

Study of thermal management for space platform applications

NASA Technical Reports Server (NTRS)

Oren, J. A.

1980-01-01

Techniques for the management of the thermal energy of large space platforms using many hundreds of kilowatts over a 10 year life span were evaluated. Concepts for heat rejection, heat transport within the vehicle, and interfacing were analyzed and compared. The heat rejection systems were parametrically weight optimized over conditions for heat pipe and pumped fluid approaches. Two approaches to achieve reliability were compared for: performance, weight, volume, projected area, reliability, cost, and operational characteristics. Technology needs are assessed and technology advancement recommendations are made.

Using Kokkos for Performant Cross-Platform Acceleration of Liquid Rocket Simulations

DTIC Science & Technology

2017-05-08

NUMBER (Include area code) 08 May 2017 Briefing Charts 05 April 2017 - 08 May 2017 Using Kokkos for Performant Cross-Platform Acceleration of Liquid ...ERC Incorporated RQRC AFRL-West Using Kokkos for Performant Cross-Platform Acceleration of Liquid Rocket Simulations 2DISTRIBUTION A: Approved for... Liquid Rocket Combustion Simulation SPACE simulation of rotating detonation engine (courtesy of Dr. Christopher Lietz) 3DISTRIBUTION A: Approved

Earth Orbital Science, Space in the Seventies.

ERIC Educational Resources Information Center

Corliss, William R.

This publication is part of the "Space in the Seventies" series and reviews the National Aeronautics and Space Administration's (NASA) earth orbital scientific research programs in progress and those to be pursued in the coming decade. Research in space physics is described in Part One in these areas: interplanetary monitoring platforms, small…

Microbial Monitoring of Pathogens by Comparing Multiple Real-Time PCR Platforms for Potential Space Applications

NASA Technical Reports Server (NTRS)

Birmele, Michele

2012-01-01

The International Space Station (ISS) is a closed environment wih rotations of crew and equipment each introducing their own microbial flora making it necessary to monitor the air, surfaces, and water for microbial contamination. Current microbial monitoring includes labor and time intensive methods to enumerate total bacterial and fungal cells with limited characterization during in-flight testing. Although this culture-based method has been sufficient for monitoring the ISS, future long duration missions will need to perform more comprehensive characterization in-flight, since sample return and ground characterization may not be available. A workshop was held in 2011 at the Johnson Space Center to discuss alternative methodologies and technologies suitable for microbial monitoring for these longterm exploration missions where molecular-based methodologies, such as polymerase chain reaction (PCR), were recommended. In response, a multi-center (Marshall Space Flight Center, Johnson Space Center, Jet Propulsion Laboratory, and Kennedy Space Center) collaborative research effort was initiated to explore novel commercial-off-the-shelf hardware options for spaceflight environmental monitoring. The goal was to evaluate quantitative/semi-quantitative PCR approaches to space applications for low cost in-flight rapid identification of microorganisms affecting crew safety. The initial phase of this project identified commercially available platforms that could be minimally modified to perform nominally in microgravity followed by proof-of-concept testing on the highest qualifying candidates with a universally available test organism, Salmonella enterica. The platforms evaluated during proof-of-concept testing included the iCubate 2.0(TradeMark) (iCubate, Huntsville, AL), RAZOR EX (BioFire Diagnostics; Salt Lake City, Utah) and SmartCycler(TradeMark) (Cepheid; Sunnyvale, CA). The analysis identified two potential technologies (iCubate 2.0 and RAZOR EX) that were able to perform sample-to-answer testing with cell sample concentrations between SO to 400 cells. In addition, the commercial systems were evaluated for initial flight safety and readiness, sample concentration needs were reviewed, and a competitive procurement of commercially available platforms was initiated.

Concepts and technology development towards a platform for macroscopic quantum experiments in space

NASA Astrophysics Data System (ADS)

Kaltenbaek, Rainer

Tremendous progress has been achieved in space technology over the last decade. This technological heritage promises enabling applications of quantum technology in space already now or in the near future. Heritage in laser and optical technologies from LISA Pathfinder comprises core technologies required for quantum optical experiments. Low-noise micro-thruster technology from GAIA allows achieving an impressive quality of microgravity, and passive radiative cooling approaches as in the James Webb Space Telescope may be adapted for achieving cryogenic temperatures. Developments like these have rendered space an increasingly attractive platform for quantum-enhanced sensing and for fundamental tests of physics using quantum technology. In particular, there already have been significant efforts towards ralizing atom interferometry and atomic clocks in space as well as efforts to harness space as an environment for fundamental tests of physics using quantum optomechanics and high-mass matter-wave interferometry. Here, we will present recent efforts in spacecraft design and technology development towards this latter goal in the context of the mission proposal MAQRO.

Analysis of the Motion Control Methods for Stratospheric Balloon-Borne Gondola Platform

NASA Astrophysics Data System (ADS)

Wang, H. H.; Yuan, Z. H.; Wu, J.

2006-10-01

At present, gondola platform is one of the stratospheric balloon-borne platforms being in research focus at home and overseas. Comparing to other stratospheric balloon-borne platforms, such as airship platform, gondola platform has advantages of higher stability, rapid in motion regulation and lower energy cost but disadvantages of less supporting capacity and be incapable of fixation. While all platforms have the same goal of keeping them at accurate angle and right pose for the requirements of instruments and objects installed in the platforms, when platforms rotate round the ground level perpendicular. That is accomplishing motion control. But, platform control system has factors of low damper, excessive and uncertain disturbances by the reason of its being hung over balloon in the air, it is hard to achieve the desired control precision because platform is ease to deviate its benchmark motion. Thus, in the controlling procedure in order to get higher precision, it is crucial to perceive the platform's swing synchronously and rapidly, and restrain the influence of disturbances effectively, keep the platform's pose steadily. Furthermore, while the platform in the air regard control center in the ground as reference object, it is ultimate to select a appropriate reference frame and work out the coordinates and implement the adjustment by the PC104 controller. This paper introduces the methods of the motion control based on stratospheric balloon-borne gondola platform. Firstly, this paper compares the characteristic of the flywheel and CMG and specifies the key methods of obtaining two significant states which are 'orientation stability' state and 'orientation tracking' state for platform motion control procedure using CMG as the control actuator. These two states reduce the deviation amplitude of rotation and swing of gondola's motion relative to original motion due to stratospheric intense atmosphere disturbance. We define it as the first procedure. In next procedure, we use the transfer matrix of earth reference frame to geographic reference frame to transform the data measured by the magnetic orientation sensors and the gyroscope to the space orientations, then the PC104 controller use the space orientations value as feedback to complete revises.

View of VAB from Mobile Launcher

NASA Image and Video Library

2017-03-13

A view of the north side of the Vehicle Assembly Building (VAB) from the top of the mobile launcher tower at NASA's Kennedy Space Center in Florida. Inside the VAB, 10 levels of platforms, 20 platform halves altogether, have been installed in High Bay 3. The platforms will surround NASA's Space Launch System (SLS) rocket and the Orion spacecraft and allow access during processing for missions, including the first uncrewed flight test of Orion atop the SLS rocket in 2018. Crawler-transporter 2 will carry the rocket and spacecraft atop the mobile launcher to Launch Pad 39B for Exploration Mission 1. The Ground Systems Development and Operations Program, with support from the center's Engineering Directorate, is overseeing upgrades and modifications to the VAB and the mobile launcher.

Recent Successes and Future Plans for NASA's Space Communications and Navigation Testbed on the International Space Station

NASA Technical Reports Server (NTRS)

Reinhart, Richard C.; Sankovic, John M.; Johnson, Sandra K.; Lux, James P.; Chelmins, David T.

2014-01-01

Flexible and extensible space communications architectures and technology are essential to enable future space exploration and science activities. NASA has championed the development of the Space Telecommunications Radio System (STRS) software defined radio (SDR) standard and the application of SDR technology to reduce the costs and risks of using SDRs for space missions, and has developed an on-orbit testbed to validate these capabilities. The Space Communications and Navigation (SCaN) Testbed (previously known as the Communications, Navigation, and Networking reConfigurable Testbed (CoNNeCT)) is advancing SDR, on-board networking, and navigation technologies by conducting space experiments aboard the International Space Station. During its first year(s) on-orbit, the SCaN Testbed has achieved considerable accomplishments to better understand SDRs and their applications. The SDR platforms and software waveforms on each SDR have over 1500 hours of operation and are performing as designed. The Ka-band SDR on the SCaN Testbed is NASAs first space Ka-band transceiver and is NASA's first Ka-band mission using the Space Network. This has provided exciting opportunities to operate at Ka-band and assist with on-orbit tests of NASA newest Tracking and Data Relay Satellites (TDRS). During its first year, SCaN Testbed completed its first on-orbit SDR reconfigurations. SDR reconfigurations occur when implementing new waveforms on an SDR. SDR reconfigurations allow a radio to change minor parameters, such as data rate, or complete functionality. New waveforms which provide new capability and are reusable across different missions provide long term value for reconfigurable platforms such as SDRs. The STRS Standard provides guidelines for new waveform development by third parties. Waveform development by organizations other than the platform provider offers NASA the ability to develop waveforms itself and reduce its dependence and costs on the platform developer. Each of these new waveforms requires a waveform build environment for the particular SDR, helps assess the usefulness of the platform provider documentation, and exercises the objectives of STRS Standard and the SCaN Testbed. There is considerable interest in conducting experiments using the SCaN Testbed from NASA, academia, commercial companies, and other space agencies. There are approximately 25 experiments or activities supported by the project underway or in development, with more proposals ready, as time and funding allow, and new experiment solicitations available. NASA continues development of new waveforms and applications in communications, networking, and navigation, the first university experimenters are beginning waveform development, which will support the next generation of communications engineers, and international interest is beginning with space agency partners from European Space Agency (ESA) and the Centre National d'Etudes Spatiales (CNES). This paper will provide an overview of the SCaN Testbed and discuss its recent accomplishments and experiment activities.Its recent successes in Ka-band operations, reception of the newest GPS signals, SDR reconfigurations, and STRS demonstration in space when combined with the future experiment portfolio have positioned the SCaN Testbed to enable future space communications and navigation capabilities for exploration and science.

KC-135 materials handling robotics

NASA Technical Reports Server (NTRS)

Workman, Gary L.

1991-01-01

Robot dynamics and control will become an important issue for implementing productive platforms in space. Robotic operations will become necessary for man-tended stations and for efficient performance of routine operations in a manned platform. The current constraints on the use of robotic devices in a microgravity environment appears to be due to an anticipated increase in acceleration levels due to manipulator motion and for safety concerns. The objective of this study will be to provide baseline data to meet that need. Most texts and papers dealing with the kinematics and dynamics of robots assume that the manipulator is composed of joints separated by rigid links. However, in recent years several groups have begun to study the dynamics of flexible manipulators, primarily for applying robots in space and for improving the efficiency and precision of robotic systems. Robotic systems which are being planned for implementation in space have a number of constraints to overcome. Additional concepts which have to be worked out in any robotic implementation for a space platform include teleoperation and degree of autonomous control. Some significant results in developing a robotic workcell for performing robotics research on the KC-135 aircraft in preperation for space-based robotics applications in the future were generated. In addition, it was shown that TREETOPS can be used to simulate the dynamics of robot manipulators for both space and ground-based applications.

A platform for European CMOS image sensors for space applications

NASA Astrophysics Data System (ADS)

Minoglou, K.; San Segundo Bello, D.; Sabuncuoglu Tezcan, D.; Haspeslagh, L.; Van Olmen, J.; Merry, B.; Cavaco, C.; Mazzamuto, F.; Toqué-Trésonne, I.; Moirin, R.; Brouwer, M.; Toccafondi, M.; Preti, G.; Rosmeulen, M.; De Moor, P.

2017-11-01

Both ESA and the EC have identified the need for a supply chain of CMOS imagers for space applications which uses solely European sources. An essential requirement on this supply chain is the platformization of the process modules, in particular when it comes to very specific processing steps, such as those required for the manufacturing of backside illuminated image sensors. This is the goal of the European (EC/FP7/SPACE) funded project EUROCIS. All EUROCIS partners have excellent know-how and track record in the expertise fields required. Imec has been leading the imager chip design and the front side and backside processing. LASSE, as a major player in the laser annealing supplier sector, has been focusing on the optimization of the process related to the backside passivation of the image sensors. TNO, known worldwide as a top developer of instruments for scientific research, including space research and sensors for satellites, has contributed in the domain of optical layers for space instruments and optimized antireflective coatings. Finally, Selex ES, as a world-wide leader for manufacturing instruments with expertise in various space missions and programs, has defined the image sensor specifications and is taking care of the final device characterization. In this paper, an overview of the process flow, the results on test structures and imagers processed using this platform will be presented.

Geostationary platform systems concepts definition follow-on study. Volume 2A: Technical Task 2 LSST special emphasis

NASA Technical Reports Server (NTRS)

1980-01-01

The results of the Large Space Systems Technology special emphasis task are presented. The task was an analysis of structural requirements deriving from the initial Phase A Operational Geostationary Platform study.

Definition of satellite servicing technology development missions for early space stations. Volume 2: Technical

NASA Technical Reports Server (NTRS)

1983-01-01

Early space station accommodation, build-up of space station manipulator capability, on-orbit spacecraft assembly test and launch, large antenna structure deployment, service/refurbish satellite, and servicing of free-flying materials processing platform are discussed.

Regional Patterns in Invertebrate Assemblages on Offshore Oil Platforms Along the Pacific Outer Continental Shelf

NASA Astrophysics Data System (ADS)

Zaleski, S.; Page, H. M.; Miller, R. J.; Doheny, B.; Dugan, J. E.; Schroeder, D. M.

2016-02-01

Twenty-seven oil and gas platforms are arrayed offshore California from north of Point Conception south to San Pedro Bay (a coastline distance of >300 km). To test the hypothesis that variability in the structure of sessile invertebrate communities on the platforms is associated with regional differences in sea surface temperature, we sampled space-holding invertebrate taxa photographically on 23 platforms and compared the composition and cover of invertebrates among and within regions using multivariate analyses. To explore temporal variability in invertebrate assemblages, we also compared the cover and composition of invertebrates on a subset of platforms in the Santa Barbara Channel (SBC) where data were collected over ten years previously. The composition of invertebrate assemblages differed significantly among regions, and was driven by variation in the relative abundance of certain anemone, bryozoan, tubiferous annelid, sponge, and bivalve taxa. The presence of non-native bryozoan and anemone taxa on some platforms in the south (San Pedro Bay) and southeast SBC contributed to the distinction of these assemblages from the others. Comparison of survey data on the subset of platforms in the SBC surveyed over ten years apart revealed little change in the cover of major space-holding taxa (e.g., anemones Metridium, Corynactis) across platforms, although there was an increase in cover of the non-native bryozoan Watersipora subtorquata between surveys. The existence of geographical patterns in the composition of platform invertebrate assemblages suggests that these assemblages may be useful as barometers of short and longer-term environmental change. For biogeographic transition zones, such as the SBC, monitoring of platform invertebrate assemblages could permit an evaluation of the concept that these zones are particularly susceptible to shifts in the composition of marine species driven by ocean climate.

The ISES: A non-intrusive medium for in-space experiments in on-board information extraction

NASA Technical Reports Server (NTRS)

Murray, Nicholas D.; Katzberg, Stephen J.; Nealy, Mike

1990-01-01

The Information Science Experiment System (ISES) represents a new approach in applying advanced systems technology and techniques to on-board information extraction in the space environment. Basically, what is proposed is a 'black box' attached to the spacecraft data bus or local area network. To the spacecraft the 'black box' appears to be just another payload requiring power, heat rejection, interfaces, adding weight, and requiring time on the data management and communication system. In reality, the 'black box' is a programmable computational resource which eavesdrops on the data network, taking and producing selectable, real-time science data back on the network. This paper will present a brief overview of the ISES Concept and will discuss issues related to applying the ISES to the polar platform and Space Station Freedom. Critical to the operation of ISES is the viability of a payload-like interface to the spacecraft data bus or local area network. Study results that address this question will be reviewed vis-a-vis the solar platform and the core space station. Also, initial results of processing science and other requirements for onboard, real-time information extraction will be presented with particular emphasis on the polar platform. Opportunities for a broader range of applications on the core space station will also be discussed.

ER-2 High Altitude Solar Cell Calibration Flights

NASA Technical Reports Server (NTRS)

Myers, Matthew; Wolford, David; Snyder, David; Piszczor, Michael

2015-01-01

Evaluation of space photovoltaics using ground-based simulators requires primary standard cells which have been characterized in a space or near-space environment. Due to the high cost inherent in testing cells in space, most primary standards are tested on high altitude fixed wing aircraft or balloons. The ER-2 test platform is the latest system developed by the Glenn Research Center (GRC) for near-space photovoltaic characterization. This system offers several improvements over GRC's current Learjet platform including higher altitude, larger testing area, onboard spectrometers, and longer flight season. The ER-2 system was developed by GRC in cooperation with NASA's Armstrong Flight Research Center (AFRC) as well as partners at the Naval Research Laboratory and Air Force Research Laboratory. The system was designed and built between June and September of 2014, with the integration and first flights taking place at AFRC's Palmdale facility in October of 2014. Three flights were made testing cells from GRC as well as commercial industry partners. Cell performance data was successfully collected on all three flights as well as solar spectra. The data was processed using a Langley extrapolation method, and performance results showed a less than half a percent variation between flights, and less than a percent variation from GRC's current Learjet test platform.

STS-95 Space Shuttle Discovery rollout to Launch Pad 39B

NASA Technical Reports Server (NTRS)

1998-01-01

As daylight creeps over the horizon, STS-95 Space Shuttle Discovery, on the Mobile Launch Platform, arrives at Launch Complex Pad 39B after a 4.2-mile trip taking approximately 6 hours. At the left is the 'white room,' attached to the orbiter access arm. The white room is an environmental chamber that mates with the orbiter and holds six persons. At the launch pad, the orbiter, external tank and solid rocket boosters will undergo final preparations for the launch, scheduled to lift off Oct. 29. The mission includes research payloads such as the Spartan solar- observing deployable spacecraft, the Hubble Space Telescope Orbital Systems Test Platform, the International Extreme Ultraviolet Hitchhiker, as well as the SPACEHAB single module with experiments on space flight and the aging process.

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialists Andrew Thomas and Soichi Noguchi look at the leading edge of Discovery’s wing with RCC panels removed. Noguchi is with the Japanese Aerospace and Exploration Agency. Crew members are at KSC becoming familiar with Shuttle and mission equipment. The mission is Logistics Flight 1, which is scheduled to deliver supplies and equipment plus the external stowage platform to the International Space Station.

NASA Image and Video Library

2004-03-05

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialists Andrew Thomas and Soichi Noguchi look at the leading edge of Discovery’s wing with RCC panels removed. Noguchi is with the Japanese Aerospace and Exploration Agency. Crew members are at KSC becoming familiar with Shuttle and mission equipment. The mission is Logistics Flight 1, which is scheduled to deliver supplies and equipment plus the external stowage platform to the International Space Station.

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialist Soichi Noguchi looks at tile on the underside of the orbiter Discovery. Noguchi is with the Japanese Aerospace and Exploration Agency. He and other crew members are at KSC becoming familiar with Shuttle and mission equipment. The mission is Logistics Flight 1, which is scheduled to deliver supplies and equipment plus the external stowage platform to the International Space Station.

NASA Image and Video Library

2004-03-05

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialist Soichi Noguchi looks at tile on the underside of the orbiter Discovery. Noguchi is with the Japanese Aerospace and Exploration Agency. He and other crew members are at KSC becoming familiar with Shuttle and mission equipment. The mission is Logistics Flight 1, which is scheduled to deliver supplies and equipment plus the external stowage platform to the International Space Station.

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialists Wendy Lawrence (left) and Stephen Robinson (right) look at the insert for Discovery’s nose cap that is being fitted with thermal protection system insulation blankets. The mission crew is spending time becoming familiar with Shuttle and mission equipment. The mission is Logistics Flight 1, which is scheduled to deliver supplies and equipment plus the external stowage platform to the International Space Station.

NASA Image and Video Library

2004-03-05

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialists Wendy Lawrence (left) and Stephen Robinson (right) look at the insert for Discovery’s nose cap that is being fitted with thermal protection system insulation blankets. The mission crew is spending time becoming familiar with Shuttle and mission equipment. The mission is Logistics Flight 1, which is scheduled to deliver supplies and equipment plus the external stowage platform to the International Space Station.

Research Opportunities on board Virgin Galactic's SpaceShipTwo

NASA Astrophysics Data System (ADS)

Attenborough, S.; Pomerantz, W.; Stephens, K.

2013-09-01

Virgin Galactic is building the world's first commercial spaceline. Our suborbital spaceflight system, pictured in Figure 1, consists of two vehicles: WhiteKnightTwo (WK2) and SpaceShipTwo (SS2). WhiteKnightTwo is a four-engine, dual-fuselage jet aircraft capable of high-altitude heavy lift missions, including, but not limited to fulfilling its role as a mothership for SpaceShipTwo, an air-launched, suborbital spaceplane capable of routinely reaching an apogee up to 110 kilometers. In conjunction, these two vehicles allow access to space and to regions of the atmosphere ranging from the troposphere to the thermosphere; additionally, they provide extended periods of microgravity in a reliable and affordable way. SpaceShipTwo, with a payload capacity of up to 1,300 lbs. (~600 kg), features payload mounting interfaces that are compatible with standard architectures such as NASA Space Shuttle Middeck Lockers, Cargo Transfer Bags, and server racks, in addition to custom structures. With the standard interface, payloads are allowed access to the large 17 inch diameter cabin windows for external observations. Each dedicated research flight will be accompanied by a Virgin Galactic Flight Test Engineer, providing an opportunity for limited in-flight interaction. In addition, tended payloads - a flight that includes the researcher and his or her payload - are also an option. At a price point that is highly competitive with parabolic aircraft and sounding rockets and significantly cheaper than orbital flights, SpaceShipTwo is a unique platform that can provide frequent and repeatable research opportunities. Suborbital flights on SpaceShipTwo offer researchers several minutes of microgravity time and views of the external environment in the upper atmosphere and in outer space. In addition to serving as an important research platform in and of itself, SpaceShipTwo also offers researchers a means to test, iterate, and calibrate experiments designed for orbital platforms, including the International Space Station as well as LauncherOne, Virgin Galactic's dedicated launch vehicle for small (~500 lbs. / ~225 kg) satellites. Flights on SpaceShipTwo can be booked directly through Virgin Galactic. Various funding sources may be available for the research, including through NASA programs such as the Flight Opportunities Program, Game Changing Development Program, or Research Opportunities in Space and Earth Science (ROSES). More information about the SpaceShipTwo research platform, including a detailed Payload User's Guide, can be found at our website: http://www.virgingalactic.com/research.

15 CFR 911.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... CONCERNING USE OF THE NOAA SPACE-BASED DATA COLLECTION SYSTEMS § 911.3 Definitions. For purposes of this part... data from fixed and moving platforms and provides platform location data. This system consists of... Data Processing and Distribution for the National Environmental Satellite, Data, and Information...

Spacelab-1: An early space station for science and technology

NASA Technical Reports Server (NTRS)

Knott, K.; Feuerbacher, B.; Chappell, C. R.

1982-01-01

The scientific capabilities of the Spacelab manned pallet are reviewed, together with the implications of an expansion of the research effectiveness with a free-flying platform. The premier Spacelab flight will carry out earth observations with a metric camera and SAR, atmospheric studies will be performed with imaging spectrometers, and space plasma physics will be examined by injecting particle beams or VLF waves into the near-Shuttle environment. Radiance and spectrum data will be gathered of the sun and UV and X ray information will be recorded from the stars. Experimentation will also be carried out for on-board crystal growth, metallurgy, and glassy material production, as well as the response of biological systems to zero-g conditions and hard space radiation. The telemetry, time, crewmember participation, and on-board controls required for Spacelab operations are outlined. Missions for a space platform for studying the atmosphere/space interface are described.

KSC-2014-2615

NASA Image and Video Library

2014-05-20

CAPE CANAVERAL, Fla. -- A crawler-transporter rolls toward Launch Pad 39A at NASA's Kennedy Space Center in Florida. Operations are underway to move Mobile Launcher Platform-2, or MLP-2, from the pad to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett

KSC-2014-2622

NASA Image and Video Library

2014-05-20

CAPE CANAVERAL, Fla. -- A crawler-transporter carries Mobile Launcher Platform-2, or MLP-2, away from Launch Pad 39A at NASA's Kennedy Space Center in Florida. The MLP is being moved to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett

Structural Dynamics and Control of Large Space Structures, 1982

NASA Technical Reports Server (NTRS)

Brumfield, M. L. (Compiler)

1983-01-01

Basic research in the control of large space structures is discussed. Active damping and control of flexible beams, active stabilization of flexible antenna feed towers, spacecraft docking, and robust pointing control of large space platform payloads are among the topics discussed.

Contamination assessment for OSSA space station IOC payloads

NASA Technical Reports Server (NTRS)

Wu, S. T.

1987-01-01

An assessment is made of NASA/OSSA space station IOC payloads. The report has two main objectives, i.e., to provide realistic contamination requirements for space station attached payloads, serviced payloads and platforms, and to determine unknowns or major impacts requiring further assessment.

Modular, Reconfigurable, High-Energy Systems Stepping Stones

NASA Technical Reports Server (NTRS)

Howell, Joe T.; Carrington, Connie K.; Mankins, John C.

2005-01-01

Modular, Reconfigurable, High-Energy Systems are Stepping Stones to provide capabilities for energy-rich infrastructure strategically located in space to support a variety of exploration scenarios. Abundant renewable energy at lunar or L1 locations could support propellant production and storage in refueling scenarios that enable affordable exploration. Renewable energy platforms in geosynchronous Earth orbits can collect and transmit power to satellites, or to Earth-surface locations. Energy-rich space technologies also enable the use of electric-powered propulsion systems that could efficiently deliver cargo and exploration facilities to remote locations. A first step to an energy-rich space infrastructure is a 100-kWe class solar-powered platform in Earth orbit. The platform would utilize advanced technologies in solar power collection and generation, power management and distribution, thermal management, and electric propulsion. It would also provide a power-rich free-flying platform to demonstrate in space a portfolio of technology flight experiments. This paper presents a preliminary design concept for a 100-kWe solar-powered satellite with the capability to flight-demonstrate a variety of payload experiments and to utilize electric propulsion. State-of-the-art solar concentrators, highly efficient multi-junction solar cells, integrated thermal management on the arrays, and innovative deployable structure design and packaging make the 100-kW satellite feasible for launch on one existing launch vehicle. Higher voltage arrays and power management and distribution (PMAD) systems reduce or eliminate the need for massive power converters, and could enable direct- drive of high-voltage solar electric thrusters.

KENNEDY SPACE CENTER, FLA. - Dressed in protective suits, STS-114 Mission Specialist Soichi Noguchi, with the Japanese Aerospace Exploration Agency (JAXA), handles equipment that will be used on the mission. He and other crew members are at KSC for equipment familiarization. STS-114 is classified as Logistics Flight 1 to the International Space Station, delivering new supplies and replacing one of the orbital outpost’s Control Moment Gyroscopes (CMGs). STS-114 will also carry a Raffaello Multi-Purpose Logistics Module and the External Stowage Platform-2. The crew is slated to conduct at least three spacewalks: They will demonstrate repair techniques of the Shuttle’s Thermal Protection System, replace the failed CMG with one delivered by the Shuttle, and install the External Stowage Platform.

NASA Image and Video Library

2004-01-27

KENNEDY SPACE CENTER, FLA. - Dressed in protective suits, STS-114 Mission Specialist Soichi Noguchi, with the Japanese Aerospace Exploration Agency (JAXA), handles equipment that will be used on the mission. He and other crew members are at KSC for equipment familiarization. STS-114 is classified as Logistics Flight 1 to the International Space Station, delivering new supplies and replacing one of the orbital outpost’s Control Moment Gyroscopes (CMGs). STS-114 will also carry a Raffaello Multi-Purpose Logistics Module and the External Stowage Platform-2. The crew is slated to conduct at least three spacewalks: They will demonstrate repair techniques of the Shuttle’s Thermal Protection System, replace the failed CMG with one delivered by the Shuttle, and install the External Stowage Platform.

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialist Andrew Thomas (right) shows some of the mission equipment to other crew members (from left) Wendy Lawrence, mission specialist; Eileen Collins, commander; and Charles Camarda, mission specialist. Crew members are at KSC for equipment familiarization. STS-114 is classified as Logistics Flight 1 to the International Space Station, delivering new supplies and replacing one of the orbital outpost’s Control Moment Gyroscopes (CMGs). STS-114 will also carry a Raffaello Multi-Purpose Logistics Module and the External Stowage Platform-2. The crew is slated to conduct at least three spacewalks: They will demonstrate repair techniques of the Shuttle’s Thermal Protection System, replace the failed CMG with one delivered by the Shuttle, and install the External Stowage Platform.

NASA Image and Video Library

2004-01-27

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialist Andrew Thomas (right) shows some of the mission equipment to other crew members (from left) Wendy Lawrence, mission specialist; Eileen Collins, commander; and Charles Camarda, mission specialist. Crew members are at KSC for equipment familiarization. STS-114 is classified as Logistics Flight 1 to the International Space Station, delivering new supplies and replacing one of the orbital outpost’s Control Moment Gyroscopes (CMGs). STS-114 will also carry a Raffaello Multi-Purpose Logistics Module and the External Stowage Platform-2. The crew is slated to conduct at least three spacewalks: They will demonstrate repair techniques of the Shuttle’s Thermal Protection System, replace the failed CMG with one delivered by the Shuttle, and install the External Stowage Platform.

SpaceDock: A Performance Task Platform for Spaceflight Operations

NASA Technical Reports Server (NTRS)

Marshburn, Thomas H.; Strangman, Gary E.; Strauss, Monica S.; Sutton, Jeffrey P.

2003-01-01

Preliminary evidence during both short- and long-duration spaceflight indicates that perceptual-motor coordination changes occur and persist in-flight. However, there is presently no in-flight method for evaluating astronaut performance on mission-critical tasks such as docking. We present a portable platform we have developed for attempting and evaluating docking, and describe the results of a pilot study wherein flight novices learned the docking task. Methods: A dual-joystick, six degrees of freedom platform-called SpaceDock-was developed to enable portable, adaptable performance testing in a spaceflight operations setting. Upon this platform, a simplified docking task was created, involving a constant rate of approach towards a docking target and requiring the user to correct translation in two dimensions and attitude orientation along one dimension (either pitch or roll). Ten flight naive subjects performed the task over a 45 min period and all joystick inputs and timings were collected, from which we could successfully reconstruct travel paths, input profiles and relative target displacements. Results: Subjects exhibited significant improvements in docking over the course of the experiment. Learning to compensate for roll-alterations was robust, whereas compensation for pitch-alterations was not in evidence in this population and relatively short training period. Conclusion: The SpaceDock platform can provide a novel method for training and testing subjects, on a spaceflight-relevant task, and can be used to examine behavioral learning, strategy use, and has been adapted for use in brain imaging experiments.

Design VHF Antennas for Space Borne Receivers for SmallSats

NASA Technical Reports Server (NTRS)

Deshpande, Manohar

2017-01-01

Space borne microwave remote sensors at VHF/UHF frequencies are important instruments to observe reflective properties of land surfaces through thick and heavy forestation on a global scale. One of the most cost effective ways of measuring land reflectivity at VHF/UHF frequencies is to use signals transmitted by existing communication satellites (operating at VHF/UHF band) as a signal of opportunity (SoOp) signal and passive receivers integrated with airborne/space borne platforms operating in the Low Earth Orbit (LEO). One of the critical components of the passive receiver is two antennas (one to receive only direct signal and other to receive only reflected signal) which need to have ideally high (>30dB) isolation. However, because of small size of host platforms and broad beam width of dipole antennas, achieving adequate isolation between two channels is a challenging problem and need to be solved for successful implementation of space borne SoOp technology for remote sensing. In this presentation a novel enabling VHF antenna technology for Cubesat platforms is presented to receive direct as well as reflected signal with needed isolation. The novel scheme also allows enhancing the gain of individual channels by factor of 2 without use of reflecting ground plane.

Prospects for Interdisciplinary Science Aboard the International Space Station

NASA Technical Reports Server (NTRS)

Robinson, Julie A.

2011-01-01

The assembly of the International Space Station was completed in early 2011, and is now embarking on its first year of the coming decade of use as a laboratory. Two key types of physical science research are enabled by ISS: studies of processes that are normally masked by gravity, and instruments that take advantage of its position as a powerful platform in orbit. The absence of buoyancy-driven convection enables experiments in diverse areas such as fluids near the critical point, Marangoni convection, combustion, and coarsening of metal alloys. The positioning of such a powerful platform in orbit with robotic transfer and instrument support also provides a unique alternative platform for astronomy and physics instruments. Some of the operating or planned instruments related to fundamental physics on the International Space Station include MAXI (Monitoring all-sky X-ray Instrument for ISS), the Alpha Magnetic Spectrometer, CALET (Calorimetric Electron Telescope), and ACES (Atomic Clock Experiment in Space). The presentation will conclude with an overview of pathways for funding different types of experiments from NASA funding to the ISS National Laboratory, and highlights of the streamlining of services to help scientists implement their experiments on ISS.

Long term orbital storage of cryogenic propellants for advanced space transportation missions

NASA Technical Reports Server (NTRS)

Schuster, John R.; Brown, Norman S.

1987-01-01

A comprehensive study has developed the major features of a large capacity orbital propellant depot for the space-based, cryogenic OTV. The study has treated both the Dual-Keel Space Station and co-orbiting platforms as the accommodations base for the propellant storage facilities, and trades have examined both tethered and hard-docked options. Five tank set concepts were developed for storing the propellants, and along with layout options for the station and platform, were evaluated from the standpoints of servicing, propellant delivery, boiloff, micrometeoroid/debris shielding, development requirements, and cost. These trades led to the recommendation that an all-passive storage concept be considered for the platform and an actively refrigerated concept providing for reliquefaction of all boiloff be considered for the Space Station. The tank sets are modular, each storing up to 45,400 kg of LO2/LH2, and employ many advanced features to provide for microgravity fluid management and to limit boiloff. The features include such technologies as zero-gravity mass gauging, total communication capillary liquid acquisition devices, autogenous pressurization, thermodynamic vent systems, thick multilayer insulation, vapor-cooled shields, solar-selective coatings, advanced micrometeoroid/debris protection systems, and long-lived cryogenic refrigeration systems.

KSC-98pc507

NASA Image and Video Library

1998-04-17

KENNEDY SPACE CENTER, FLA. -- The Space Shuttle Columbia lifts off from Launch Pad 39B at 2:19 p.m. EDT Apr. 17 to begin the nearly 17-day STS-90 Neurolab mission. A torrent of water is seen flowing onto the mobile launcher platform as several large quench nozzles, or "rainbirds," mounted on platform's surface operate as a sound suppression system. The crew members are Commander Richard Searfoss, Pilot Scott Altman, Mission Specialists Richard Linnehan, D.V.M., Dafydd (Dave) Williams, M.D., with the Canadian Space Agency, and Kathryn (Kay) Hire; and Payload Specialists Jay Buckey, M.D., and James Pawelczyk, Ph.D. Investigations during the Neurolab mission will focus on the effects of microgravity on the nervous system

Space power distribution system technology. Volume 1: Reference EPS design

NASA Technical Reports Server (NTRS)

Decker, D. K.; Cannady, M. D.; Cassinelli, J. E.; Farber, B. F.; Lurie, C.; Fleck, G. W.; Lepisto, J. W.; Massner, A.; Ritterman, P. F.

1983-01-01

The multihundred kilowatt electrical power aspects of a mannable space platform in low Earth orbit is analyzed from a cost and technology viewpoint. At the projected orbital altitudes, Shuttle launch and servicing are technically and economically viable. Power generation is specified as photovoltaic consistent with projected planning. The cost models and trades are based upon a zero interest rate (the government taxes concurrently as required), constant dollars (1980), and costs derived in the first half of 1980. Space platform utilization of up to 30 years is evaluated to fully understand the impact of resupply and replacement as satellite missions are extended. Such lifetimes are potentially realizable with Shuttle servicing capability and are economically desirable.

Modular High-Energy Systems for Solar Power Satellites

NASA Technical Reports Server (NTRS)

Howell, Joe T.; Carrington, Connie K.; Marzwell, Neville I.; Mankins, John C.

2006-01-01

Modular High-Energy Systems are Stepping Stones to provide capabilities for energy-rich infrastructure located in space to support a variety of exploration scenarios as well as provide a supplemental source of energy during peak demands to ground grid systems. Abundant renewable energy at lunar or other locations could support propellant production and storage in refueling scenarios that enable affordable exploration. Renewable energy platforms in geosynchronous Earth orbits can collect and transmit power to satellites, or to Earth-surface locations. Energy-rich space technologies also enable the use of electric-powered propulsion systems that could efficiently deliver cargo and exploration facilities to remote locations. A first step to an energy-rich space infrastructure is a 100-kWe class solar-powered platform in Earth orbit. The platform would utilize advanced technologies in solar power collection and generation, power management and distribution, thermal management, electric propulsion, wireless avionics, autonomous in space rendezvous and docking, servicing, and robotic assembly. It would also provide an energy-rich free-flying platform to demonstrate in space a portfolio of technology flight experiments. This paper summary a preliminary design concept for a 100-kWe solar-powered satellite system to demonstrate in-flight a variety of advanced technologies, each as a separate payload. These technologies include, but are not limited to state-of-the-art solar concentrators, highly efficient multi-junction solar cells, integrated thermal management on the arrays, and innovative deployable structure design and packaging to enable the 100-kW satellite feasible to launch on one existing launch vehicle. Higher voltage arrays and power distribution systems (PDS) reduce or eliminate the need for massive power converters, and could enable direct-drive of high-voltage solar electric thrusters.

Research and Technology annual report FY-1981

NASA Technical Reports Server (NTRS)

1981-01-01

Space transportation systems are summarized: space shuttle enhancement, a space operations center, the space platform, and geostationary activites are discussed. Aeronautics and space technology are summarized: experiments, energy systems, propulsion technology, synthetic aperture radar, large space systems, and shuttle-launched vehicles are discussed. Space sciences are summarized: lunar, planetary, and life sciences are discussed. Space and terrestrial applications are summarized. The AgRISTARS program, forest and wildland resource, and Texas LANDSAT applications are discussed.

Architectures Analysis for the Future European SSA System

NASA Astrophysics Data System (ADS)

Donath, Th.; Saunders, C.; Martinot, V.; Elluin, E.; Benayas, J. Rey

2009-03-01

As defined by ESA, Space Situational Awareness (SSA) is the understanding and maintained awareness of the Earth orbital population, the space environment (including NEOs) and possible threats to space assets. At the moment, European SSA is relatively poor and many studies are performed in that domain to propose an autonomous European system. At the last Ministerial Council held in November 2008, a SSA preparatory programme has been decided in order to propose the way forward in such domain and to envisage a common framework for addressing space weather (SW) and space surveillance (SS) user needs.This paper will present the analysis of the possible architectures for such system focusing on its incremental development (with respect to the services available to the users) and on the correlations between the SW and SS domains which appear when proposing cost-efficient solutions.These correlations are mainly due to the fact that some space-based assets may be required for both domains, especially Sun-Synchronous platforms or sub-GEO platforms. Sun-Synchronous platforms are interesting for space objects survey and tracking in high altitude orbits, Sun X-ray imagery, solar UV flux measurement, electrons and protons radiations or ionospheric TEC measurements. Sub-GEO platforms may be used for GEO objects imaging and environment as solar related measurements. The feasibility of such space-based assets will be presented.Other correlations are due to the fact that the future European SSA system has to be considered as an information system acquiring, processing and providing data to users. The data policy and security aspects for such system will be especially important to be analysed. This paper will present the possible relations with the Users of such system depending on available data and subscribed services and depending also on their profiles. Another important point to be managed by the system is the access to resources which will also depend on the users' profiles. At last, the volume of data, the amount of time processing will be major topics which will size directly the ground segment design and cost and need to be analysed.

A Common DPU Platform for ESA JUICE Mission Instruments

NASA Astrophysics Data System (ADS)

Aberg, Martin; Hellstrom, Daniel; Samuelsson, Arne; Torelli, Felice

2016-08-01

This paper describes the resulting hardware and software platform based on GR712RC [1] LEON3-FT that Cobham Gaisler developed in accordance with the common system requirements of the ten scientific instruments on-board the ESA JUICE spacecraft destined the Jupiter system [8].The radiation hardened DPU platform features EDAC protected boot, application memory and working memory of configurable sizes and SpaceWire, FPGA I/O-32/16/8, GPIO, UART and SPI I/O interfaces. The design has undergone PSA, Risk, WCA, Radiation analyses etc. to justify component and design choices resulting in a robust design that can be used in spacecrafts requiring a total dose up to 100krad(Si). The prototype board manufactured uses engineering models of the flight components to ensure that development is representative.Validated boot, standby and driver software accommodates the various DPU platform configurations. The boot performs low-level DPU initialization, standby handles OBC SpaceWire communication and finally the loading and executing of application images typically stored in the non-volatile application memory.

Space Experiment Concepts: Cup-Burner Flame Extinguishment

NASA Technical Reports Server (NTRS)

Takahashi, Fumiaki

2004-01-01

Space Fire Suppression Processes & Technology. Space experiment concepts of cup-burner flame extinguishment have been conceived to address to the key issues (i.e., organizing questions) in space fire suppression. Cup-burner flame extinguishment experiment can reveal physical and chemical suppression processes and provide agent effectiveness data useful for technology development of space fire suppression systems in various reduced-gravity platforms.

General view of a fully assembled Solid Rocket Booster sitting ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

General view of a fully assembled Solid Rocket Booster sitting atop the Mobile Launch Platform in the Vehicle Assembly Building at Kennedy Space Center - Space Transportation System, Solid Rocket Boosters, Lyndon B. Johnson Space Center, 2101 NASA Parkway, Houston, Harris County, TX

Large space systems technology, 1980, volume 1

NASA Technical Reports Server (NTRS)

Kopriver, F., III (Compiler)

1981-01-01

The technological and developmental efforts in support of the large space systems technology are described. Three major areas of interests are emphasized: (1) technology pertient to large antenna systems; (2) technology related to large space systems; and (3) activities that support both antenna and platform systems.

Space Shuttle Projects

NASA Image and Video Library

1989-04-25

An STS-41D onboard photo shows the Solar Array Experiment (SAE) panel deployment for the Office of Aeronautics and space Technology-1 (OAST-1). OAST-1 is several advanced space technology experiments utilizing a common data system and is mounted on a platform in the Shuttle cargo bay.

Research on capability of detecting ballistic missile by near space infrared system

NASA Astrophysics Data System (ADS)

Lu, Li; Sheng, Wen; Jiang, Wei; Jiang, Feng

2018-01-01

The infrared detection technology of ballistic missile based on near space platform can effectively make up the shortcomings of high-cost of traditional early warning satellites and the limited earth curvature of ground-based early warning radar. In terms of target detection capability, aiming at the problem that the formula of the action distance based on contrast performance ignores the background emissivity in the calculation process and the formula is only valid for the monochromatic light, an improved formula of the detecting range based on contrast performance is proposed. The near space infrared imaging system parameters are introduced, the expression of the contrastive action distance formula based on the target detection of the near space platform is deduced. The detection range of the near space infrared system for the booster stage ballistic missile skin, the tail nozzle and the tail flame is calculated. The simulation results show that the near-space infrared system has the best effect on the detection of tail-flame radiation.

Geostationary platform study: Advanced ESGP/evolutionary SSF accommodation study

NASA Technical Reports Server (NTRS)

1990-01-01

The implications on the evolutionary space station of accommodating geosynchronous Earth Orbit (GEO) facilities including unmanned satellites and platforms, manned elements, and transportation and servicing vehicles/elements. The latest existing definitions of typical unmanned GEO facilities and transportation and servicing vehicles/elements are utilized. The physical design, functional design, and operations implications at the space station are determined. Various concepts of the space station from past studies are utilized ranging from the IOC Multifunction Space Station to a branched transportation node space station, and the implications of the accommodation the GEO infrastructure of each type are assessed. Where possible, parametric data are provided to show the implications of variations in sizes and quantities of elements, launch rates, crew sizes, etc. The use of advanced automation, robotics equipment, and an efficient mix of manned/automated support for accomplishing necessary activities at the space station are identified and assessed. The products of this study are configuration sketches, resource requirements, trade studies, and parametric data.

SCA Waveform Development for Space Telemetry

NASA Technical Reports Server (NTRS)

Mortensen, Dale J.; Kifle, Multi; Hall, C. Steve; Quinn, Todd M.

2004-01-01

The NASA Glenn Research Center is investigating and developing suitable reconfigurable radio architectures for future NASA missions. This effort is examining software-based open-architectures for space based transceivers, as well as common hardware platform architectures. The Joint Tactical Radio System's (JTRS) Software Communications Architecture (SCA) is a candidate for the software approach, but may need modifications or adaptations for use in space. An in-house SCA compliant waveform development focuses on increasing understanding of software defined radio architectures and more specifically the JTRS SCA. Space requirements put a premium on size, mass, and power. This waveform development effort is key to evaluating tradeoffs with the SCA for space applications. Existing NASA telemetry links, as well as Space Exploration Initiative scenarios, are the basis for defining the waveform requirements. Modeling and simulations are being developed to determine signal processing requirements associated with a waveform and a mission-specific computational burden. Implementation of the waveform on a laboratory software defined radio platform is proceeding in an iterative fashion. Parallel top-down and bottom-up design approaches are employed.

STS-114: Discovery Day 9 Mission Status Briefing

NASA Technical Reports Server (NTRS)

2005-01-01

Paul Hill, STS-114 Lead Shuttle Flight Director, Mark Ferring, STS-114 Lead ISS Flight Director and Cindy Begley, STS-114 Lead EVA Officer is shown during this 9th day of the Space Shuttle Mission to the International Space Station. Paul Hill talks about the status of the transfers of critical items to the International Space Station and transfers back from the International Space Station into the Multi-Purpose Logistics Module (MPLM). Hill also presents footage of the crew cabin blanket survey procedure. Mark Ferring talks in detail about the primary International Space Station task on the External Stowage Platform (ESP). The status of the external stowage platform installation, removal of grapple fixture, gap filler removal task, and Materials International Space Station Experiment (MISSE) 5 payload installation is discussed by Cindy Begley. She also presents footage of Steve Robinson's spacewalk before the gap filler task and during the removal of the gap filler. The Capture of ESP-2 is also presented. The presentation ends with a question and answer period from the news media

MOM-E: Moon-Orbiting Mothership Explorer

NASA Technical Reports Server (NTRS)

Murphy, Gloria A.

2010-01-01

The National Aeronautics and Space Administration proposed that a new class of robotic space missions and spacecrafts be introduced to "ensure that future missions are safe, sustainable and affordable". Indeed, the United States space program aims for a return to manned space missions beyond Earth orbit, and robotic explorers are intended to pave the way. This vision requires that all future missions become less costly, provide a sustainable business plan, and increase in safety. Over the course of several fast feasibility studies that considered the 3 drivers above, the small-scale, consumer-driven Moon-Orbiting Mothership Explorer (MOM-E) mission was born. MOM-E's goals are to enable space exploration by offering a scaled down platform which carries multiple small space explorers to the Moon. Each payload will be dropped at their desired destination, offering a competitive price to customers. MOM-E's current scope of operations is limited to the Moon and will be used as a proof of concept mission. However, MOM-E is specifically designed with the idea that the platform is scalable.

Geostationary platform systems concepts definition study. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

1980-01-01

The results of a geostationary platform concept analysis are summarized. Mission and payloads definition, concept selection, the requirements of an experimental platform, supporting research and technology, and the Space Transportation System interface requirements are addressed. It is concluded that platforms represent a logical extension of current trends toward larger, more complex, multifrequency satellites. Geostationary platforms offer significant cost savings compared to individual satellites, with the majority of these economies being realized with single Shuttle launched platforms. Further cost savings can be realized, however, by having larger platforms. Platforms accommodating communications equipment that operates at multiple frequencies and which provide larger scale frequency reuse through the use of large aperture multibeam antennas and onboard switching maximize the useful capacity of the orbital arc and frequency spectrum. Projections of market demand indicate that such conservation measures are clearly essential if orderly growth is to be provided for. In addition, it is pointed out that a NASA experimental platform is required to demonstrate the technologies necessary for operational geostationary platforms of the 1990's.

Nanocomposites in Multifuntional Structures for Spacecraft Platforms

NASA Astrophysics Data System (ADS)

Marcos, J.; Mendizabal, M.; Elizetxea, C.; Florez, S.; Atxaga, G.; Del Olmo, E.

2012-07-01

The integration of functionalities as electrical, thermal, power or radiation shielding inside carrier electronic boxes, solar panels or platform structures allows reducing weight, volume, and harness for spacecraft. The multifunctional structures represent an advanced design approach for space components and subsystems. The development of such multifunctional structures aims the re-engineering traditional metallic structures by composites in space, which request to provide specific solutions for thermal conductivity, EMI-EMC, radiation shielding and integration. The use of nanomaterials as CNF and nano-adds to reinforce composite structures allows obtaining local solutions for improving electrical conductivity, thermal conductivity and radiation shielding. The paper summarises the results obtained in of three investigations conducted by Tecnalia based on carbon nanofillers for improving electro-thermal characteristics of spacecraft platform, electronic substrates and electronics boxes respectively.

Aurorasaurus: A citizen science platform for viewing and reporting the aurora

NASA Astrophysics Data System (ADS)

MacDonald, E. A.; Case, N. A.; Clayton, J. H.; Hall, M. K.; Heavner, M.; Lalone, N.; Patel, K. G.; Tapia, A.

2015-09-01

A new, citizen science-based, aurora observing and reporting platform has been developed with the primary aim of collecting auroral observations made by the general public to further improve the modeling of the aurora. In addition, the real-time ability of this platform facilitates the combination of citizen science observations with auroral oval models to improve auroral visibility nowcasting. Aurorasaurus provides easily understandable aurora information, basic gamification, and real-time location-based notification of verified aurora activity to engage citizen scientists. The Aurorasaurus project is one of only a handful of space weather citizen science projects and can provide useful results for the space weather and citizen science communities. Early results are promising with over 2000 registered users submitting over 1000 aurora observations and verifying over 1700 aurora sightings posted on Twitter.

KSC-07pd0006

NASA Image and Video Library

2007-01-03

KENNEDY SPACE CENTER, FLA. -- Elevated platforms are seen hanging in front of the NASA Logo on the side of Kennedy Space Center's Vehicle Assembly Building. Also in view on the east side of the building are platforms on the facility's large vertical doors. Workers, suspended on the platforms from the top of the 525-foot-high VAB, use rollers and brushes to do the painting. The flag and logo were last painted in 1998, honoring NASA's 40th anniversary. The flag spans an area 209 feet by 110 feet, or about 23, 437 square feet. Each stripe is 9 feet wide and each star is 6 feet in diameter. The logo, also known as the "meatball," measures 110 feet by 132 feet, or about 12,300 square feet. Photo credit: NASA/George Shelton

KSC-02pd0398

NASA Image and Video Library

2002-04-04

KENNEDY SPACE CENTER, FLA. -- At Launch Pad 39B, an inspection team gathers at the foot of Mobile Launcher Platform where Space Shuttle Atlantis sits. Earlier today a leak in a ground support liquid hydrogen vent line on the south side of the Mobile Launcher Platform caused a scrub of the launch of Atlantis on mission STS-110. An engineering team is assessing the situation to determine the best method to repair the hydrogen line. The turnaround plan includes time to perfor weld repairs and return the vehicle to a timeline to resume the countdown

KSC-02pd0396

NASA Image and Video Library

2002-04-04

KENNEDY SPACE CENTER, FLA. -- At Launch Pad 39B, workers on a crane inspect pipes on the Mobile Launcher Platform where Space Shuttle Atlantis sits. Earlier today a leak in a ground support liquid hydrogen vent line on the south side of the Mobile Launcher Platform caused a scrub of the launch of Atlantis on mission STS-110. An engineering team is assessing the situation to determine the best method to repair the hydrogen line. The turnaround plan includes time to perfor weld repairs and return the vehicle to a timeline to resume the countdown

Thermal management of instruments on space platforms using a high capacity two-phase heat transport system

NASA Technical Reports Server (NTRS)

Ollendorf, S.; Fowle, A.; Almgren, D.

1981-01-01

A system utilizing a pumped, two-phase single component working fluid for heat exchange and transport services necessary to meet the temperature control requirements of typical orbiting instrument payloads on space platforms is described. The design characteristics of the system is presented, together with a presentation of a laboratory apparatus for demonstration of proof of concept. Results indicate that the pumped two-phase design concept can meet a wide range of thermal performance requirements with the only penalty being the requirement for a small liquid pump.

KENNEDY SPACE CENTER, FLA. - A camera is installed on the aft skirt of a solid rocket booster in preparation for a vibration test of the Mobile Launcher Platform with SRBs and external tank mounted. The MLP will roll from one bay to another in the Vehicle Assembly Building.

NASA Image and Video Library

2003-11-06

KENNEDY SPACE CENTER, FLA. - A camera is installed on the aft skirt of a solid rocket booster in preparation for a vibration test of the Mobile Launcher Platform with SRBs and external tank mounted. The MLP will roll from one bay to another in the Vehicle Assembly Building.

Use of nonlinear design optimization techniques in the comparison of battery discharger topologies for the space platform

NASA Technical Reports Server (NTRS)

Sable, Dan M.; Cho, Bo H.; Lee, Fred C.

1990-01-01

A detailed comparison of a boost converter, a voltage-fed, autotransformer converter, and a multimodule boost converter, designed specifically for the space platform battery discharger, is performed. Computer-based nonlinear optimization techniques are used to facilitate an objective comparison. The multimodule boost converter is shown to be the optimum topology at all efficiencies. The margin is greatest at 97 percent efficiency. The multimodule, multiphase boost converter combines the advantages of high efficiency, light weight, and ample margin on the component stresses, thus ensuring high reliability.

Of drops and bubbles - The technology of space processing

NASA Technical Reports Server (NTRS)

Subramanian, R. Shankar

1984-01-01

It is possible to manipulate a large, molten mass of material, such as a glass, aboard an orbital platform using acoustic fields. Attention is presently given to the problem of bubble removal from such a melt; it is desirable to make small bubbles coalesce into larger ones through floating melt rotation, to create an artificial convective field in which the bubbles will move centripetally to the axis of rotation. Computer models of bubble migration have been developed in order to define the operational conditions required aboard such experiment platforms as the Space Shuttle Orbiter.

Around Marshall

NASA Image and Video Library

1995-03-23

A diver tests a secondary camera and maneuvering platform in Marshall's Neutral Buoyancy Simulator (NBS).The secondary camera will be beneficial for recording repairs and other extra vehicular activities (EVA) the astronuats will perform while making repairs on the Hubble Space Telescope (HST). The maneuvering platform was developed to give the astronauts something to stand on while performing maintenance tasks. These platforms were developed to be mobile so that the astronauts could move them to accommadate different sites.

Power turbine ventilation system

NASA Technical Reports Server (NTRS)

Wakeman, Thomas G. (Inventor); Brown, Richard W. (Inventor)

1991-01-01

Air control mechanism within a power turbine section of a gas turbine engine. The power turbine section includes a rotor and at least one variable pitch propulsor blade. The propulsor blade is coupled to and extends radially outwardly of the rotor. A first annular fairing is rotatable with the propulsor blade and interposed between the propulsor blade and the rotor. A second fairing is located longitudinally adjacent to the first fairing. The first fairing and the second fairing are differentially rotatable. The air control mechanism includes a platform fixedly coupled to a radially inner end of the propulsor blade. The platform is generally positioned in a first opening and a first fairing. The platform and the first fairing define an outer space. In a first position corresponding with a first propulsor blade pitch, the platform is substantially conformal with the first fairing. In a second position corresponding with the second propulsor blade pitch, an edge portion of the platform is displaced radially outwardly from the first fairing. When the blades are in the second position and rotating about the engine axis, the displacement of the edge portion with respect to the first fairing allows air to flow from the outer space to the annular cavity.

Payload canister for Discovery is lifted in place for transfer

NASA Technical Reports Server (NTRS)

1998-01-01

At left, the payload canister for Space Shuttle Discovery is lifted from its canister movement vehicle to the top of the Rotating Service Structure on Launch Pad 39-B. Discovery (right), sitting atop the Mobile Launch Platform and next to the Fixed Service Structure (FSS), is scheduled for launch on Oct. 29, 1998, for the STS-95 mission. That mission includes the International Extreme Ultraviolet Hitchhiker (IEH-3), the Hubble Space Telescope Orbital Systems Test Platform, the Spartan solar- observing deployable spacecraft, and the SPACEHAB single module with experiments on space flight and the aging process. At the top of the FSS can be seen the 80-foot lightning mast . The 4- foot-high lightning rod on top helps prevent lightning current from passing directly through the Space Shuttle and the structures on the pad.

KENNEDY SPACE CENTER, FLA. - STS-114 Commander Eileen Collins and Mission Specialists Charles Camarda and Soichi Noguchi sit outside the crew hatch on the orbiter Discovery. Noguchi is with the Japanese Aerospace and Exploration Agency. They and other crew members are at KSC becoming familiar with Shuttle and mission equipment. The mission is Logistics Flight 1, which is scheduled to deliver supplies and equipment plus the external stowage platform to the International Space Station.

NASA Image and Video Library

2004-03-05

KENNEDY SPACE CENTER, FLA. - STS-114 Commander Eileen Collins and Mission Specialists Charles Camarda and Soichi Noguchi sit outside the crew hatch on the orbiter Discovery. Noguchi is with the Japanese Aerospace and Exploration Agency. They and other crew members are at KSC becoming familiar with Shuttle and mission equipment. The mission is Logistics Flight 1, which is scheduled to deliver supplies and equipment plus the external stowage platform to the International Space Station.

Survivability of immunoassay reagents exposed to the space radiation environment on board the ESA BIOPAN-6 platform as a prelude to performing immunoassays on Mars.

PubMed

Derveni, Mariliza; Allen, Marjorie; Sawakuchi, Gabriel O; Yukihara, Eduardo G; Richter, Lutz; Sims, Mark R; Cullen, David C

2013-01-01

The Life Marker Chip (LMC) instrument is an immunoassay-based sensor that will attempt to detect signatures of life in the subsurface of Mars. The molecular reagents at the core of the LMC have no heritage of interplanetary mission use; therefore, the design of such an instrument must take into account a number of risk factors, including the radiation environment that will be encountered during a mission to Mars. To study the effects of space radiation on immunoassay reagents, primarily antibodies, a space study was performed on the European Space Agency's 2007 BIOPAN-6 low-Earth orbit (LEO) space exposure platform to complement a set of ground-based radiation studies. Two antibodies were used in the study, which were lyophilized and packaged in the intended LMC format and loaded into a custom-made sample holder unit that was mounted on the BIOPAN-6 platform. The BIOPAN mission went into LEO for 12 days, after which all samples were recovered and the antibody binding performance was measured via enzyme-linked immunosorbent assays (ELISA). The factors expected to affect antibody performance were the physical conditions of a space mission and the exposure to space conditions, primarily the radiation environment in LEO. Both antibodies survived inactivation by these factors, as concluded from the comparison between the flight samples and a number of shipping and storage controls. This work, in combination with the ground-based radiation tests on representative LMC antibodies, has helped to reduce the risk of using antibodies in a planetary exploration mission context.

Matroshka AstroRad Radiation Experiment (MARE) on the Deep Space Gateway

NASA Astrophysics Data System (ADS)

Gaza, R.; Hussein, H.; Murrow, D.; Hopkins, J.; Waterman, G.; Milstein, O.; Berger, T.; Przybyla, B.; Aeckerlein, J.; Marsalek, K.; Matthiae, D.; Rutczynska, A.

2018-02-01

The Matroshka AstroRad Radiation Experiment is a science payload on Orion EM-1 flight. A research platform derived from MARE is proposed for the Deep Space Gateway. Feedback is invited on desired Deep Space Gateway design features to maximize its science potential.

KENNEDY SPACE CENTER, FLA. - Members of the STS-114 crew take a look at the Japanese Experiment Module (JEM) pressure module in the Space Station Processing Facility. A research laboratory, the pressurized module is the first element of the JEM, named "Kibo" (Hope), to be delivered to KSC. The National Space Development Agency of Japan (NASDA) developed the laboratory at the Tsukuba Space Center near Tokyo and is Japan's primary contribution to the Station. The JEM also includes an exposed facility (platform) for space environment experiments, a robotic manipulator system, and two logistics modules. The various JEM components will be assembled in space over the course of three Shuttle missions.

NASA Image and Video Library

2003-06-09

KENNEDY SPACE CENTER, FLA. - Members of the STS-114 crew take a look at the Japanese Experiment Module (JEM) pressure module in the Space Station Processing Facility. A research laboratory, the pressurized module is the first element of the JEM, named "Kibo" (Hope), to be delivered to KSC. The National Space Development Agency of Japan (NASDA) developed the laboratory at the Tsukuba Space Center near Tokyo and is Japan's primary contribution to the Station. The JEM also includes an exposed facility (platform) for space environment experiments, a robotic manipulator system, and two logistics modules. The various JEM components will be assembled in space over the course of three Shuttle missions.

GSFC contamination monitors for Space Station

NASA Technical Reports Server (NTRS)

Carosso, P. A.; Tveekrem, J. L.; Coopersmith, J. D.

1988-01-01

This paper describes the Work Package 3 activities in the area of neutral contamination monitoring for the Space Station. Goddard Space Flight Center's responsibilities include the development of the Attached Payload Accommodations Equipment (APAE), the Polar Orbiting Platform (POP), and the Flight Telerobotic Servicer (FTS). GSFC will also develop the Customer Servicing Facility (CSF) in Phase 2 of the Space Station.

Space Station needs, attributes and architectural options, volume 2, book 2, part 4: International reports

NASA Technical Reports Server (NTRS)

1983-01-01

The capabilities of the European Space Agency's SPAS and EURECA platforms for reference payload accommodation are considered. The instrument pointing subsystem, the position and hold mount, and the antenna pointing mechanism developed by Dornier are described. Relevant payloads for the space station are summarized and space station accommodation aspects are discussed.

Space construction system analysis. Part 2: Cost and programmatics

NASA Technical Reports Server (NTRS)

Vonflue, F. W.; Cooper, W.

1980-01-01

Cost and programmatic elements of the space construction systems analysis study are discussed. The programmatic aspects of the ETVP program define a comprehensive plan for the development of a space platform, the construction system, and the space shuttle operations/logistics requirements. The cost analysis identified significant items of cost on ETVP development, ground, and flight segments, and detailed the items of space construction equipment and operations.

Space Science Cloud: a Virtual Space Science Research Platform Based on Cloud Model

NASA Astrophysics Data System (ADS)

Hu, Xiaoyan; Tong, Jizhou; Zou, Ziming

Through independent and co-operational science missions, Strategic Pioneer Program (SPP) on Space Science, the new initiative of space science program in China which was approved by CAS and implemented by National Space Science Center (NSSC), dedicates to seek new discoveries and new breakthroughs in space science, thus deepen the understanding of universe and planet earth. In the framework of this program, in order to support the operations of space science missions and satisfy the demand of related research activities for e-Science, NSSC is developing a virtual space science research platform based on cloud model, namely the Space Science Cloud (SSC). In order to support mission demonstration, SSC integrates interactive satellite orbit design tool, satellite structure and payloads layout design tool, payload observation coverage analysis tool, etc., to help scientists analyze and verify space science mission designs. Another important function of SSC is supporting the mission operations, which runs through the space satellite data pipelines. Mission operators can acquire and process observation data, then distribute the data products to other systems or issue the data and archives with the services of SSC. In addition, SSC provides useful data, tools and models for space researchers. Several databases in the field of space science are integrated and an efficient retrieve system is developing. Common tools for data visualization, deep processing (e.g., smoothing and filtering tools), analysis (e.g., FFT analysis tool and minimum variance analysis tool) and mining (e.g., proton event correlation analysis tool) are also integrated to help the researchers to better utilize the data. The space weather models on SSC include magnetic storm forecast model, multi-station middle and upper atmospheric climate model, solar energetic particle propagation model and so on. All the services above-mentioned are based on the e-Science infrastructures of CAS e.g. cloud storage and cloud computing. SSC provides its users with self-service storage and computing resources at the same time.At present, the prototyping of SSC is underway and the platform is expected to be put into trial operation in August 2014. We hope that as SSC develops, our vision of Digital Space may come true someday.

29 CFR 1910.30 - Other working surfaces.

Code of Federal Regulations, 2011 CFR

2011-07-01

... published by the U.S. Department of Commerce, which is incorporated by reference as specified in § 1910.6... removing material. This aisle space is to be independent of working and storage space. (3) Wood platforms...

Observing the Anthropocene from Space

NASA Astrophysics Data System (ADS)

Dittus, Hansjörg

2016-07-01

Influence of mankind on Earth's climate is evident. The growing population using the resources available, especially by burning goal, oil and gas, changes the composition of the Earth's atmosphere with the result of a continuously increasing temperature. Effects are not limited to the regional scale but are evident on the whole planet, meanwhile named Anthropocene. According to this global influence, it's necessary to also extend monitoring to the entire planet. Space-based observation systems are not limited by any artificial borders and are in principle able, to cover the whole Earth. In principle, two different ways of observation can be selected: Either a dedicated spacecraft will be send into low earth orbit (LEO) or existing platforms are used. Advantages of satellites are the more or less freely selectable orbit (with orbits covering also the polar regions) and the possible adaption of spacecraft platform for the dedicated instrument. On the other hand platforms like the ISS space station enable continuous long term coverage with different instruments. The drawback of an only limited coverage based on the orbit inclination is made up by the possibility to service systems on the station. Furthermore different generations of sensors can be run in parallel and therefore cross calibrated if needed. This paper reviews the currently available sensors types and discusses potential future needs. Included in this discussion is the international space station as an already available platform for earth observation. Furthermore, discussion should also take into account, that an increasing number of constellations with dozens or even thousand satellites are planned. Are these constellations also an option for an increased temporal and spatial monitoring of the Earth?

KSC-2009-2301

NASA Image and Video Library

2009-03-25

CAPE CANAVERAL, Fla. – NASA's Kennedy Space Center management host a ceremony near Launch Pad 39B to mark the handover of Mobile Launcher Platform-1 (behind them) from NASA's Space Shuttle Program to the Constellation Program for the Ares I-X flight test targeted for this summer. Seated are (left) Shuttle Launch Director Mike Leinbach and (right) Pepper E. Phillips, director of the Constellation Project Office, and Brett Raulerson, manager of MLP Operations with United Space Alliance. At the podium is Rita Willcoxon, director of Launch Vehicle Processing at Kennedy. Constructed in 1964, the mobile launchers used in Apollo/Saturn operations were modified for use in shuttle operations. With cranes, umbilical towers and swing arms removed, the mobile launchers were renamed Mobile Launcher Platforms, or MLPs. Photo credit: NASA/Kim Shiflett

Automated distribution system management for multichannel space power systems

NASA Technical Reports Server (NTRS)

Fleck, G. W.; Decker, D. K.; Graves, J.

1983-01-01

A NASA sponsored study of space power distribution system technology is in progress to develop an autonomously managed power system (AMPS) for large space power platforms. The multichannel, multikilowatt, utility-type power subsystem proposed presents new survivability requirements and increased subsystem complexity. The computer controls under development for the power management system must optimize the power subsystem performance and minimize the life cycle cost of the platform. A distribution system management philosophy has been formulated which incorporates these constraints. Its implementation using a TI9900 microprocessor and FORTH as the programming language is presented. The approach offers a novel solution to the perplexing problem of determining the optimal combination of loads which should be connected to each power channel for a versatile electrical distribution concept.

Space construction system analysis. Part 2: Construction analysis

NASA Technical Reports Server (NTRS)

Roebuck, J. A.; Buck, P. A.; Gimlich, G. W.; Greenberg, H. S.; Hart, R. J.; Indrikis, J.; Lefever, A. E.; Lillenas, A. N.; Mcbaine, C. K.

1980-01-01

The construction methods specific to the end to end construction process for building the ETVP in low Earth orbit, using the space shuttle orbiter as a construction base, are analyzed. The analyses concerned three missions required to build the basic platform. The first mission involved performing the fabrication of beams in space and assembling the beams into a basic structural framework. The second mission was to install the forward support structure and aft support structure, the forward assembly, and a TT&C antenna. The third mission plan was to complete the construction of the platform and activate it to begin operations in low Earth orbit. The integration of the activities for each mission is described along with the construction requirements and construction logic.

Autonomous onboard crew operations: A review and developmental approach

NASA Technical Reports Server (NTRS)

Rogers, J. G.

1982-01-01

A review of the literature generated by an intercenter mission approach and consolidation team and their contractors was performed to obtain background information on the development of autonomous operations concepts for future space shuttle and space platform missions. The Boeing 757/767 flight management system was examined to determine the relevance for transfer of the developmental approach and technology to the performance of the crew operations function. In specific, the engine indications and crew alerting system was studied to determine the relevance of this display for the performance of crew operations onboard the vehicle. It was concluded that the developmental approach and technology utilized in the aeronautics industry would be appropriate for development of an autonomous operations concept for the space platform.

Water-propellant resistojets for man-tended platforms

NASA Technical Reports Server (NTRS)

Louviere, Allen J.; Jones, Robert E.; Morren, W. Earl; Sovey, James S.

1987-01-01

The selection of a propulsion system for a man-tended platform has been influenced by the planned use of resistojets for drag make-up on the manned space station. For that application a resistojet has been designed that is capable of operation with a wide variety of propellants, including water. The reasons for the selection of water as the propellant and the performance of water as a propellant are discussed. The man-tended platform and its mission requirements are described.

High Altitude Balloons as a Platform for Space Radiation Belt Science

NASA Astrophysics Data System (ADS)

Mazzino, L.; Buttenschoen, A.; Farr, Q.; Hodgson, C.; Johnson, W.; Mann, I. R.; Rae, J.; University of Alberta High Altitude Balloons (UA-HAB)

2011-12-01

The goals of the University of Alberta High Altitude Balloons Program (UA-HAB) are to i) use low cost balloons to address space radiation science, and ii) to utilise the excitement of "space mission" involvement to promote and facilitate the recruitment of undergraduate and graduate students in physics, engineering, and atmospheric sciences to pursue careers in space science and engineering. The University of Alberta High Altitude Balloons (UA-HAB) is a unique opportunity for University of Alberta students (undergraduate and graduate) to engage in the hands-on design, development, build, test and flight of a payload to operate on a high altitude balloon at around 30km altitude. The program development, including formal design and acceptance tests, reports and reviews, mirror those required in the development of an orbital satellite mission. This enables the students to gain a unique insight into how space missions are flown. UA-HAB is a one and half year program that offers a gateway into a high-altitude balloon mission through hands on experience, and builds skills for students who may be attracted to participate in future space missions in their careers. This early education will provide students with the experience necessary to better assess opportunities for pursuing a career in space science. Balloons offer a low-cost alternative to other suborbital platforms which can be used to address radiation belt science goals. In particular, the participants of this program have written grant proposal to secure funds for this project, have launched several 'weather balloon missions', and have designed, built, tested, and launched their particle detector called "Maple Leaf Particle Detector". This detector was focussed on monitoring cosmic rays and space radiation using shielded Geiger tubes, and was flown as one of the payloads from the institutions participating in the High Altitude Student Platform (HASP), organized by the Louisiana State University and the Louisiana Space Consortium (LaSpace), and sponsored by NASA. The HASP platform was launched from Fort Sumner, New Mexico, and to an altitude of about 36kilometers with flight durations of 15 to 20 hours using a small volume, low pressure balloon. The main objectives of the program, the challenges involved in developing it, and the major achievements and outcomes will be discussed. Future opportunities for the use of high altitude balloons for solar-terrestrial science, such as the diagnosis of radiation belt loss through the flight of alternative X-ray scintillator payloads, on short duration weather balloon flights will also be discussed. The UA-HAB project is undertaken with the financial support of the Canadian Space Agency.

Active disturbance rejection controller of fine tracking system for free space optical communication

NASA Astrophysics Data System (ADS)

Cui, Ning; Liu, Yang; Chen, Xinglin; Wang, Yan

2013-08-01

Free space optical communication is one of the best approaches in future communications. Laser beam's acquisition, pointing and tracking are crucial technologies of free space optical communication. Fine tracking system is important component of APT (acquisition, pointing and tracking) system. It cooperates with the coarse pointing system in executing the APT mission. Satellite platform vibration and disturbance, which reduce received optical power, increase bit error rate and affect seriously the natural performance of laser communication. For the characteristic of satellite platform, an active disturbance rejection controller was designed to reduce the vibration and disturbance. There are three major contributions in the paper. Firstly, the effects of vibration on the inter satellite optical communications were analyzed, and the reasons and characters of vibration of the satellite platform were summarized. The amplitude-frequency response of a filter was designed according to the power spectral density of platform vibration of SILEX (Semiconductor Inter-satellite Laser Experiment), and then the signals of platform vibration were generated by filtering white Gaussian noise using the filter. Secondly, the fast steering mirror is a key component of the fine tracking system for optical communication. The mechanical design and model analysis was made to the tip/tilt mirror driven by the piezoelectric actuator and transmitted by the flexure hinge. The transfer function of the fast steering mirror, camera, D/A data acquisition card was established, and the theory model of transfer function of this system was further obtained. Finally, an active disturbance rejection control method is developed, multiple parallel extended state observers were designed for estimation of unknown dynamics and external disturbance, and the estimated states were used for nonlinear feedback control and compensation to improve system performance. The simulation results show that the designed controller not only accurately estimates and compensates the disturbances, but also realizes the robustness to estimation of unknown dynamics. The controller can satisfy the requirement of fine tracking accuracy for free space optical communication system.

SNAP (Space Nuclear Auxiliary Power) Reactor Overview

DTIC Science & Technology

1984-08-01

so that emphasis could be placed on the development of the space shuttle and the national space station . During 1969 NASA came up with a requirement...which would need the Zr-H reactor system which was the semipermanent orbiting space station . This helped the Zr-H system weather through the major FY 71...provide power for advanced space missions, such as lunar stations or orbiting space platforms, and for interplanetary com- munications. In addition