Science.gov

Sample records for species file nos

  1. 78 FR 32622 - Endangered Species; File Nos. 17557 and 17273

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ...Notice is hereby given that the National Ocean Service Marine Forensic Lab (NOS Lab) [Responsible Party: M. Katherine Moore], 219 Fort Johnson Road, Charleston, SC 29412 (File No. 17557), and the NOAA Fisheries Northeast Region, Protected Resources Division [Responsible Party: Mary Colligan], 1 Blackburn Drive, Gloucester, MA 01930 (File No. 17273), have applied in due form for permits to take......

  2. 78 FR 50395 - Endangered Species; File Nos. 17557 and 17273

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-19

    ...Notice is hereby given that the National Ocean Service Marine Forensic Lab (NOS Lab) [Responsible Party: M. Katherine Moore], 219 Fort Johnson Road, Charleston, SC 29412 (File No. 17557), and the NOAA Fisheries Northeast Region, Protected Resources Division [Responsible Party: Mary Colligan], 1 Blackburn Drive, Gloucester, MA 01930 (File No. 17273), have been issued permits to take marine......

  3. 76 FR 15300 - Endangered Species; File Nos. 16266 and 16291

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-21

    ... Virginia Living Museum, 524 J. Clyde Morris Boulevard, Newport News, VA, 23602 [Chris Crippen, Responsible... educating the public on shortnose sturgeon life history and the reasons for the species decline....

  4. 77 FR 1061 - Endangered Species; File Nos. 16229 and 16548

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-09

    ... Zoo, 4401 Zoo ] Parkway, Asheboro, NC 27203 , and the Springfield Science Museum, 21 Edwards Street... species (50 CFR parts 222-226). The North Carolina Zoo and the Springfield Science Museum have been issued... (1) were applied for in good faith, (2) will not operate to the disadvantage of such endangered...

  5. 77 FR 21754 - Endangered Species; File Nos. 16526, 16323, 16436, 16422, 16438, 16431, 16507, 16547, 16375...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-11

    ..., 16436, 16422, 16438, 16431, 16507, 16547, 16375, 16442, 16482, and 16508 AGENCY: National Marine... 222-226). File No. 16526 The Maine Department of Marine Resources, Gail Wippelhauser, Ph.D... Department of Environmental Protection Marine Fisheries, Tom Savoy (RP), PO Box 719, Old Lyme, CT 06371,...

  6. 75 FR 9580 - Marine Mammals and Endangered Species; File Nos. 13544 and 14586

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-03

    ..., importing, and exporting of endangered and threatened species (50 CFR 222-226).Permit No. 13544 authorizes..., weighed, and tagged with Inconel and passive integrated transponder tags. Tissue samples are collected for....), the regulations governing the taking and importing of marine mammals (50 CFR part 216), the...

  7. 75 FR 61133 - Marine Mammals and Endangered Species; File Nos. 808-1735, 14233, 14506, 14603, and 14726

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-04

    ... amendment to conduct research ] on marine mammals or sea turtles. See SUPPLEMENTARY INFORMATION for... leatherback (Dermochelys coriacea) sea turtles had been submitted by Llewellyn Ehrhart, Ph.D. [File No. 14506... research on green, hawksbill, Kemp's ridley, loggerhead, and leatherback sea turtles had been submitted...

  8. 76 FR 30309 - Marine Mammals and Endangered Species; File Nos. 14245, 1596-03, and 14726-01

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-25

    ... or sea turtles. ADDRESSES: The permit, permit modifications, and related documents are available for... Fisheries Science Center (SWFSC; File No. 1596- 03) for research on sea turtles. The SWFSC (Dr. Lisa... research on leatherback (Dermochelys coriacea) sea turtles captured off the western coast of...

  9. 77 FR 12010 - Marine Mammals; File Nos. 1076-1789 and 14502

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-28

    ... National Oceanic and Atmospheric Administration RIN 0648-XB040 Marine Mammals; File Nos. 1076-1789 and... to Scientific Research Permit Nos. 1076-1789 and 14502. ADDRESSES: The amendment and related... importing of marine mammals (50 CFR part 216). Permit No. 1076-1789: This permit, issued on March 13,...

  10. 75 FR 42689 - Marine Mammals; File Nos. 15498 and 15500

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-22

    ..., NW., Atlanta, GA 30313 have been issued permits to import Atlantic bottlenose dolphins (Tursiops... display permits to import bottlenose dolphins had been submitted by the above-named organizations. File No. 15498 requested the importation of one male and one female captive born bottlenose dolphin from...

  11. 76 FR 18725 - Marine Mammals; File Nos. 14330 and 14335

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-05

    ... (50 CFR parts 222-226), and the Fur Seal Act of 1966, as amended (16 U.S.C. 1151 et seq.). File No... Northern Fur Seal Research (NMFS 2007), and that issuance of the permit amendments would not have...

  12. 76 FR 51945 - Endangered Species; File No. 16548

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-19

    ... National Oceanic and Atmospheric Administration RIN 0648-XA648 Endangered Species; File No. 16548 AGENCY... Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No. 16548 from the list of...- 0376, or by email to NMFS.Pr1Comments@noaa.gov . Please include the File No. 16548 in the subject...

  13. 75 FR 67682 - Endangered Species; File No. 15566

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-03

    ... National Oceanic and Atmospheric Administration RIN 0648-XA013 Endangered Species; File No. 15566 AGENCY... Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No. 15566 from the..., Permits, Conservation and Education Division: By e-mail to NMFS.Pr1Comments@noaa.gov (include the File...

  14. 78 FR 38013 - Endangered Species; File No. 15661

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-25

    ... National Oceanic and Atmospheric Administration RIN 0648-XA425 Endangered Species; File No. 15661 AGENCY... Protected Species (APPS) home page, https://apps.nmfs.noaa.gov/ , and then selecting File No. 15661 from the... facsimile to (301) 713-0376, or by email to NMFS.Pr1Comments@noaa.gov . Please include the File No. in...

  15. 75 FR 26715 - Endangered Species; File No. 1596

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ... Endangered Species; File No. 1596 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and... Protected Species (APPS) home page, https://apps.nmfs.noaa.gov/ , and then selecting File No. 1596-03 from... following document identifier: File No. 1596-03. FOR FURTHER INFORMATION CONTACT: Amy Hapeman or Kate...

  16. 76 FR 51001 - Marine Mammals; File Nos. 16109 and 15575

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ... 44 species to be targeted for research are listed as threatened or endangered: blue whale (Balaenoptera musculus), fin whale (B. physalus), humpback whale (Megaptera novaeangliae), North Atlantic right whale (Eubalaena glacialis), sei whale (B. borealis), sperm whale (Physeter macrocephalus), green...

  17. 77 FR 27719 - Marine Mammals; File Nos. 16109 and 15575

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-11

    ... targeted for research are listed as threatened or endangered: Blue whale (Balaenoptera musculus), fin whale (B. physalus), humpback whale (Megaptera novaeangliae), North Atlantic right whale (Eubalaena... species to be targeted for research are listed as threatened or endangered: Blue whale, fin...

  18. 76 FR 27306 - Endangered Species; File No. 15661

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    ... National Oceanic and Atmospheric Administration RIN 0648-XA425 Endangered Species; File No. 15661 AGENCY... requested under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq... Permits for Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File...

  19. 75 FR 13488 - Endangered Species; File No. 14949

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-22

    ... National Oceanic and Atmospheric Administration RIN 0648-XV33 Endangered Species; File No. 14949 AGENCY...://apps.nmfs.noaa.gov/ , and then selecting File No. 14949 from the list of available applications. These... the subject line of the e-mail comment the following document identifier: File No. 14949. FOR...

  20. 77 FR 58812 - Endangered Species; File No. 17316

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-24

    ... National Oceanic and Atmospheric Administration RIN 0648-XC252 Endangered Species; File No. 17316 AGENCY... page, https://apps.nmfs.noaa.gov , and then selecting File No. 17316 from the list of available... By email to NMFS.Pr1Comments@noaa.gov (include the File No. in the subject line of the email),...

  1. 76 FR 45230 - Endangered Species; File No. 15802

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-28

    ... National Oceanic and Atmospheric Administration RIN 0648-XA603 Endangered Species; File No. 15802 AGENCY...://apps.nmfs.noaa.gov , and then selecting File No. 15802 from the list of available applications. These... e-mail to NMFS.Pr1Comments@noaa.gov (include the File No. in the subject line of the e-mail),...

  2. 77 FR 13096 - Endangered Species; File No. 16598

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-05

    ... National Oceanic and Atmospheric Administration RIN 0648-XB054 Endangered Species; File No. 16598 AGENCY... page, https://apps.nmfs.noaa.gov , and then selecting File No. 16598 from the list of available... Division: By email to NMFS.Pr1Comments@noaa.gov (include the File No. in the subject line of the email),...

  3. 77 FR 58812 - Endangered Species; File No. 16733

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-24

    ... National Oceanic and Atmospheric Administration RIN 0648-XC253 Endangered Species; File No. 16733 AGENCY....gov , and then selecting File No. 16733 from the list of available applications. These documents are...@noaa.gov (include the File No. in the subject line of the email), By facsimile to (301)713-0376, or...

  4. 76 FR 35842 - Endangered Species; File No. 15685

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-20

    ... Endangered Species; File No. 15685 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and... selecting File No. 15685 from the list of available applications. These documents are also available upon....Pr1Comments@noaa.gov (include the File No. in the subject line of the e-mail), By facsimile to...

  5. 77 FR 34349 - Endangered Species; File No. 16803

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ... National Oceanic and Atmospheric Administration RIN 0648-XC058 Endangered Species; File No. 16803 AGENCY... Permits for Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No... the Chief, Permits and Conservation Division by email to NMFS.Pr1Comments@noaa.gov (include the...

  6. 75 FR 33578 - Endangered Species; File Nos. 14508 and 14655

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-14

    ... Ave South, St. Petersburg, FL 33701; phone (727) 824-5312; fax (727) 824-5309. FOR FURTHER INFORMATION... abundance, genetic origin and feeding ecology of sea turtles using Lake Worth Lagoon in Palm Beach County, Florida. Up to 50 green, 5 loggerhead, 2 hawksbill, and 1 Kemp's ridley sea turtles may be...

  7. 76 FR 37065 - Endangered Species; File Nos. 16266 and 16291

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-24

    ... shortnose sturgeon for purposes of enhancement. ADDRESSES: The permit and related documents are available... shortnose sturgeon had been submitted by the above- named organizations. The requested permits have been..., non-releaseable adult shortnose sturgeon. The permit does not authorize any takes from the wild,...

  8. 77 FR 21753 - Endangered Species; File Nos. 13599 and 1614

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-11

    ... Northeast Region Protected Resources Division [Responsible Party: Mary Colligan], One Blackburn Drive..., NMFS, One Blackburn Drive, Gloucester, MA 01930- 2298; phone (978) 281-9300; fax (978) 281-9394;...

  9. 76 FR 80890 - Endangered Species; File Nos. 13599 and 1614

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-27

    ... samples would be used to support law enforcement actions, research studies (primarily genetics), and...), Commerce. ACTION: Notice; receipt of applications for permit modifications. SUMMARY: Notice is hereby given that the following applicants have applied in due form for modifications to their scientific...

  10. 77 FR 67631 - Endangered Species; File Nos. 17367 and 17364

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-13

    ... 17364 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration..., physiology, propagation, contaminants, genetics, fish health, cryopreservation, tagging, refugia, and other... Fisheries Center providing a source of research animals for studies related to tagging, tracking,...

  11. 77 FR 21750 - Endangered Species; File Nos. 16549 and 17095

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-11

    ... and downstream migrations, habitat use, spawning periodicity, seasonal movements of shortnose sturgeon... animal research in laboratory tests of up- and downstream fish passage studies, swimming...

  12. 78 FR 17640 - Endangered Species; File Nos. 17367 and 17364

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-22

    .... Research would include, but is not limited to, nutrition, physiology, propagation, contaminants, genetics... research animals for studies related to tagging, tracking, behavior, physiology, genetics,...

  13. 77 FR 21751 - Endangered Species; File No. 16645

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XB152 Endangered Species; File No. 16645 AGENCY... comments will be accepted in Microsoft Word or Excel, WordPerfect, or Adobe PDF file formats only....

  14. 78 FR 41034 - Endangered Species; File No. 18102

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-09

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XC711 Endangered Species; File No. 18102 AGENCY...). Attachments to electronic comments will be accepted in Microsoft Word, Excel, or Adobe PDF file formats...

  15. 77 FR 15997 - Endangered Species; File No. 15672

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XB083 Endangered Species; File No. 15672 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration (NOAA),...

  16. 78 FR 59657 - Endangered Species; File No. 17304

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XC667 Endangered Species; File No. 17304 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration (NOAA),...

  17. 75 FR 7443 - Endangered Species; File No. 14381

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XU26 Endangered Species; File No. 14381 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration (NOAA),...

  18. 78 FR 22517 - Endangered Species; File No. 16549

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XB155 Endangered Species; File No. 16549 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration (NOAA),...

  19. 76 FR 66042 - Endangered Species; File No. 1551

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA785 Endangered Species; File No. 1551 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration (NOAA),...

  20. 78 FR 22239 - Endangered Species; File No. 16556

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XC037 Endangered Species; File No. 16556 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration (NOAA),...

  1. 77 FR 24686 - Endangered Species; File No. 15634

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA714 Endangered Species; File No. 15634 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration (NOAA),...

  2. 78 FR 2659 - Endangered Species; File No. 16645

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XB152 Endangered Species; File No. 16645 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration (NOAA),...

  3. 77 FR 30261 - Endangered Species; File No. 16306

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA712 Endangered Species; File No. 16306 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration (NOAA),...

  4. 76 FR 32144 - Endangered Species; File No. 15677

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-03

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA467 Endangered Species; File No. 15677 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration (NOAA),...

  5. 77 FR 40588 - Endangered Species; File No. 16598

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XB054 Endangered Species; File No. 16598 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration (NOAA),...

  6. 75 FR 78227 - Endangered Species; File No. 14400

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA085 Endangered Species; File No. 14400 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration (NOAA),...

  7. 78 FR 38952 - Endangered Species; File No. 17506

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-28

    ... National Oceanic and Atmospheric Administration RIN 0648-XC518 Endangered Species; File No. 17506 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration (NOAA), Commerce... Resources, National Marine Fisheries Service. BILLING CODE 3510-22-P...

  8. 75 FR 21601 - Endangered Species; File No. 14604

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... National Oceanic and Atmospheric Administration RIN 0648-XV94 Endangered Species; File No. 14604 AGENCY... Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.) and the regulations governing the taking, importing, and exporting of endangered and threatened species (50 CFR parts 222-226)....

  9. 76 FR 18725 - Endangered Species; File No. 16174

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-05

    ... National Oceanic and Atmospheric Administration RIN 0648-XA348 Endangered Species; File No. 16174 AGENCY... subject permit is requested under the authority of the Endangered Species Act of 1973, as amended (ESA; 16... endangered and threatened species (50 CFR 222-226). Dr. Salmon proposes to characterize juvenile green...

  10. 76 FR 77780 - Endangered Species; File No. 10022

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-14

    ... National Oceanic and Atmospheric Administration RIN 0648-XA867 Endangered Species; File No. 10022 AGENCY... the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.) and the regulations governing the taking, importing, and exporting of endangered and threatened species (50 CFR 222-226)....

  11. 77 FR 55194 - Endangered Species; File No. 17095

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-07

    ... National Oceanic and Atmospheric Administration RIN 0648-XB155 Endangered Species; File No. 17095 AGENCY... issued under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq... endangered or threatened species, and (3) is consistent with the purposes and policies set forth in section...

  12. 76 FR 76950 - Endangered Species; File No. 16134

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-09

    ... National Oceanic and Atmospheric Administration RIN 0648-XA848 Endangered Species; File No. 16134 AGENCY.... SUPPLEMENTARY INFORMATION: The subject permit is requested under the authority of the Endangered Species Act of... exporting of endangered and threatened species (50 CFR parts 222-226). The applicant requests a...

  13. 78 FR 15706 - Endangered Species; File No. 17316

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-12

    ... National Oceanic and Atmospheric Administration RIN 0648-XC252 Endangered Species; File No. 17316 AGENCY... individual. The requested permit has been issued under the authority of the Endangered Species Act of 1973... exporting of endangered and threatened species (50 CFR parts 222-226). The permit holder is authorized...

  14. 76 FR 48146 - Endangered Species; File No. 1551

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-08

    ... National Oceanic and Atmospheric Administration RIN 0648-XA620 Endangered Species; File No. 1551 AGENCY.... 1551- 02 is requested under the authority of the Endangered Species Act of 1973, as amended (16 U.S.C... the Features box on the Applications and Permits for Protected Species (APPS) home page,...

  15. 77 FR 65673 - Endangered Species; File No. 16248

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-30

    ... National Oceanic and Atmospheric Administration RIN 0648-XC322 Endangered Species; File No. 16248 AGENCY... requested under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq... history and the reasons for the species decline. The proposed project to display endangered...

  16. 76 FR 58471 - Endangered Species; File No. 16306

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-21

    ... National Oceanic and Atmospheric Administration RIN 0648-XA712 Endangered Species; File No. 16306 AGENCY... requested under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq... the Applications and Permits for Protected Species (APPS) home page, https://apps.nmfs.noaa.gov ,...

  17. 77 FR 57559 - Endangered Species; File No. 13330

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-18

    ... National Oceanic and Atmospheric Administration RIN 0648-XB144 Endangered Species; File No. 13330 AGENCY... modification has been granted under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U... the disadvantage of such endangered or threatened species, and (3) is consistent with the purposes...

  18. 75 FR 53278 - Endangered Species; File No. 14759

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-31

    ... National Oceanic and Atmospheric Administration RIN 0648-XY58 Endangered Species; File No. 14759 AGENCY... individual. The requested permit has been issued under the authority of the Endangered Species Act of 1973... exporting of endangered and threatened species (50 CFR parts 222-226). The applicant is authorized...

  19. 78 FR 29114 - Endangered Species; File No. 17304

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-17

    ... National Oceanic and Atmospheric Administration RIN 0648-XC667 Endangered Species; File No. 17304 AGENCY... INFORMATION: The subject permit is requested under the authority of the Endangered Species Act of 1973, as... of endangered and threatened species (50 CFR parts 222-226). The applicant requests a...

  20. 75 FR 11862 - Endangered Species; File No. 14759

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... National Oceanic and Atmospheric Administration RIN 0648-XV04 Endangered Species; File No. 14759 AGENCY... the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.), and the regulations governing the taking, importing, and exporting of endangered and threatened species (50 CFR 222-226)....

  1. 76 FR 48806 - Endangered Species; File No. 16194

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-09

    ... National Oceanic and Atmospheric Administration RIN 0648-XA625 Endangered Species; File No. 16194 AGENCY... the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.) and the regulations governing the taking, importing, and exporting of endangered and threatened species (50 CFR...

  2. 76 FR 31597 - Endangered Species; File No. 15614

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-01

    ... National Oceanic and Atmospheric Administration RIN 0648-XA452 Endangered Species; File No. 15614 AGENCY... has been issued under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C... endangered or threatened species, and (3) is consistent with the purposes and policies set forth in section...

  3. 76 FR 6118 - Endangered Species; File No. 14726

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    ...-XA179 Endangered Species; File No. 14726 AGENCY: National Marine Fisheries Service (NMFS), National... subject modification to Permit No. 14726 is requested under the authority of the Endangered Species Act of..., importing, and exporting of endangered and threatened species (50 CFR 222-226). Permit No. 14726, issued...

  4. 78 FR 5779 - Endangered Species; File No. 16248

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-28

    ... National Oceanic and Atmospheric Administration RIN 0648-XC322 Endangered Species; File No. 16248 AGENCY... organization. The requested permit has been issued under the authority of the Endangered Species Act of 1973... exporting of endangered and threatened species (50 CFR parts 222-226). The Riverbanks Zoo and Garden...

  5. 75 FR 4043 - Endangered Species; File No. 14396

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-26

    ... National Oceanic and Atmospheric Administration RIN 0648-XT92 Endangered Species; File No. 14396 AGENCY... Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.) and the regulations governing the taking, importing, and exporting of endangered and threatened species (50 CFR parts 222-226)....

  6. 75 FR 13256 - Endangered Species; File No. 14176

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-19

    ... National Oceanic and Atmospheric Administration RIN 0648-XV28 Endangered Species; File No. 14176 AGENCY... permit is requested under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C... Applications and Permits for Protected Species (APPS) home page, https://apps.nmfs.noaa.gov/ , and...

  7. 77 FR 1671 - Endangered Species; File No. 16194

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-11

    ... National Oceanic and Atmospheric Administration RIN 0648-XA925 Endangered Species; File No. 16194 AGENCY... been issued under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531... good faith, (2) will not operate to the disadvantage of such endangered or threatened species, and...

  8. 76 FR 40699 - Endangered Species; File No. 16229

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-11

    ... National Oceanic and Atmospheric Administration RIN 0648-XA516 Endangered Species; File No. 16229 AGENCY... the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.) and the regulations governing the taking, importing, and exporting of endangered and threatened species (50 CFR 222-226)....

  9. 78 FR 17355 - Endangered Species; File No. 17787

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-21

    ... National Oceanic and Atmospheric Administration RIN 0648-XC576 Endangered Species; File No. 17787 AGENCY... INFORMATION: The subject permit is requested under the authority of the Endangered Species Act of 1973, as... of endangered and threatened species (50 CFR parts 222-226). The applicant proposes to gather...

  10. 77 FR 31586 - Endangered Species; File No. 16556

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-29

    ... National Oceanic and Atmospheric Administration RIN 0648-XC037 Endangered Species; File No. 16556 AGENCY.... SUPPLEMENTARY INFORMATION: The subject permit is requested under the authority of the Endangered Species Act of... exporting of endangered and threatened species (50 CFR parts 222-226). The NEFSC requests a five-year...

  11. 76 FR 44306 - Endangered Species; File No. 16146

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-25

    ... National Oceanic and Atmospheric Administration RIN 0648-XA583 Endangered Species; File No. 16146 AGENCY... under the ] authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq... Applications and Permits for Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and...

  12. 76 FR 19052 - Endangered Species; File No. 14344

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-06

    ... National Oceanic and Atmospheric Administration RIN 0648-XA340 Endangered Species; File No. 14344 AGENCY..., importing, and exporting of endangered and threatened species (50 CFR parts 222-226). The permit authorizes... above-named organization. The requested permit has been issued under the authority of the...

  13. 78 FR 3882 - Endangered Species; File No. 13543

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-17

    ... National Oceanic and Atmospheric Administration RIN 0648-XJ40 Endangered Species; File No. 13543 AGENCY... requested under the authority of the Endangered Species Act of 1973, as amended (16 U.S.C. 1531 et seq.) and the regulations governing the taking, importing, and exporting of endangered and threatened...

  14. 75 FR 61133 - Endangered Species; File No. 14176

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-04

    ... National Oceanic and Atmospheric Administration RIN 0648-XZ31 Endangered Species; File No. 14176 AGENCY... issued under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.) and the regulations governing the taking, importing, and exporting of endangered and...

  15. 77 FR 10724 - Endangered Species; File No. 16253

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-23

    ... National Oceanic and Atmospheric Administration RIN 0648-XB027 Endangered Species; File No. 16253 AGENCY... permit has been issued under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.) and the regulations governing the taking, importing, and exporting of...

  16. 75 FR 26715 - Endangered Species; File No. 10022

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ... [Federal Register Volume 75, Number 91 (Wednesday, May 12, 2010)] [Notices] [Pages 26715-26716] [FR Doc No: 2010-11338] DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XW37 Endangered Species; File No. 10022 AGENCY: National Marine Fisheries Service (NMFS),...

  17. 78 FR 31519 - Endangered Species; File No. 13543

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-24

    ... [Federal Register Volume 78, Number 101 (Friday, May 24, 2013)] [Notices] [Pages 31519-31520] [FR Doc No: 2013-12361] DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XJ40 Endangered Species; File No. 13543 AGENCY: National Marine Fisheries Service (NMFS),...

  18. 78 FR 14078 - Endangered Species; File No. 17405

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-04

    ... Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No. 17405 from the..., 1315 East-West Highway, Room 13705, Silver Spring, MD 20910; phone (301) 427-8401; fax (301) 713-0376; and Southwest Region, NMFS, 501 West Ocean Blvd., Suite 4200, Long Beach, CA 90802-4213; phone...

  19. 78 FR 51712 - Endangered Species; File No. 16733

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-21

    ... National Oceanic and Atmospheric Administration RIN 0648-XC253 Endangered Species; File No. 16733 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration (NOAA), Commerce... Division, Office of Protected Resources, National Marine Fisheries Service. BILLING CODE 3510-22-P...

  20. 76 FR 68161 - Marine Mammals; File Nos. 16163, 16160, and 15569

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-03

    ...; The Whale Museum (Jenny Atkinson, Responsible Party) [File No. 16160], PO Box 945, Friday Harbor, WA 98250; and The Center for Whale Research (CWR; Kenneth C. Balcomb III, Responsible Party) [File No... a stock listed as endangered: blue whale (Balaenoptera musculus), fin whale (B. physalus),...

  1. [COMPARATIVE CHARACTERISTICS OF uNOS-POSITIVE STRUCTURES IN THE CNS OF SOME SPECIES OF CRUSTACEANS].

    PubMed

    Chertok, V M; Kotsyuba, E P

    2015-01-01

    We conducted a comparative study of NO-ergic system in the CNS of 10 species of crustaceans subclass Malacostraca, belonging to orders Stomatopoda and Decapoda, with a common habitat in Ussuri Bay (Sea of Japan). Both similar characteristics and differences in content and distribution of universal NO-synthase (uNOS) were revealed in homologous parts of the brain and ventral nerve cord of the investigated species of crustaceans. We discuss the involvement of nitric oxide in the regulation of physiological functions of decapod crustaceans and its role in the processes of adaptation to the environmental conditions.

  2. 75 FR 43150 - Marine Mammals; File Nos. 10018, 13846, 14451, 14585, 14599, 14122, 14296, and 14353

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-23

    ... behavioral observations. Four other species of cetaceans (killer whales (Orcinus orca), Pacific white-sided... dalli)) may be incidentally harassed during research. Observed killer whales will be photographed for... killer whales (Pseudorca crassidens) may be incidentally harassed during research. Killer whales...

  3. 76 FR 58469 - Endangered Species; File Nos. 16526, 16323, 16436, 16422, 16438, 16431, 16507, 16547, 16375...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-21

    ..., 16436, 16422, 16438, 16431, 16507, 16547, 16375, 16442, 16482, and 16508. AGENCY: National Marine.... Gail Wippelhauser, PhD, of the Maine Department of Marine Resources, 21 State House Station, Augusta... telemetry tag. Tom Savoy of the Connecticut Department of Environmental Protection, Marine Fisheries,...

  4. 75 FR 76704 - Endangered Species; File Nos. 13307, 13544, and 14586

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-09

    ... given that NMFS has issued a permit and two permit modifications to take sea turtles and marine mammals... turtles and marine mammals had been submitted by Jeanette Wyneken, Florida Atlantic University, Boca Raton... Jeffrey Schmid, PhD, Conservancy of Southwest Florida, Naples, FL, for sea turtle research. On April...

  5. 75 FR 16428 - Endangered Species; File Nos. 15112 and 13307-02

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ... ridley (Lepidochelys kempii), green (Chelonia mydas), and hawksbill (Eretmochelys imbricata) sea turtles... modification to scientific research Permit No. 13307-01 to take green sea turtles. DATES: Written, telefaxed... composition of populations of sea turtles found in the commercial fishing areas of the Northwest...

  6. 76 FR 23571 - Marine Mammals and Endangered Species; File Nos. 15415 and 14622

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-27

    ... given that NMFS has issued two permits to conduct research on marine mammals or sea turtles. See...), Kemp's ridley (Lepidochelys ] kempii), and loggerhead (Caretta caretta) sea turtles had been submitted... 32218, was issued a five-year permit to: (1) Monitor the abundance of loggerhead and green sea...

  7. 77 FR 13097 - Endangered Species; File Nos. 15661, 10027, and 15685

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-05

    ... composition, foraging ecology, and migration patterns for green and hawksbill sea turtles in the Northern... focusing on distribution and abundance, ecology, health, and threats to sea turtles at the Palmyra Atoll in... Hawaiian Islands to determine growth rates, health status, stock and population structure, foraging...

  8. 78 FR 23225 - Endangered Species; File Nos. 14759-01 and 16375-01

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-18

    ... rivers (Chowan, Roanoke, Tar-Pamlico, Neuse, and Cape Fear) and estuaries (Albemarle Sound) using non... characterizing spawning activity in the Roanoke and/or Cape Fear Rivers. Specifically, it is proposed that... dam, i.e., river kilometer 221 in the Roanoke River and river kilometer 300 in the Cape Fear...

  9. 78 FR 32623 - Endangered Species; File No. 17452

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ... permit to take shortnose (Acipenser brevirostrum) and Atlantic sturgeon (Acipenser oxyrinchus oxyrinchus... shortnose sturgeon. For each species, up to 20 adult and juvenile animals would be collected annually using gill nets. Once captured, sturgeon would be measured, weighed, tissue sampled, and passive...

  10. 78 FR 66901 - Endangered Species; File No. 16482-01

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-07

    ... Features box on the Applications and Permits for Protected Species (APPS) home page, https://apps.nmfs.noaa..., MD 20910; phone (301) 427-8401; fax (301) 713-0376; and Southeast Region, NMFS, 263 13th Avenue South, Saint Petersburg, Florida 33701; phone (727) 824-5312; fax (727) 824-5309. Written comments on...

  11. 76 FR 45517 - Endangered Species; File No. 13330-01

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-29

    ... unchanged from the original permit: to collect data on the biology, distribution and abundance of the endangered smalltooth sawfish to facilitate recovery of the species. Sampling with the goal of taking 45... transmitting (PAT) tags, and Smart Position Only Transmitting (SPOT) tags. Sampling methods also include...

  12. iNOS null MRL+/+ mice show attenuation of trichloroethene-mediated autoimmunity: contribution of reactive nitrogen species and lipid-derived reactive aldehydes

    PubMed Central

    Wang, Gangduo; Wakamiya, Maki; Wang, Jianling; Ansari, G.A.S.; Khan, M. Firoze

    2015-01-01

    Earlier studies from our laboratory in MRL+/+ mice suggest that free radicals, especially overproduction of reactive nitrogen species (RNS) and lipid-derived reactive aldehydes (LDRAs), are associated with trichloroethene (TCE)-mediated autoimmune response. The current study was undertaken to further assess the contribution of RNS and LDRAs in TCE-mediated autoimmunity by using iNOS-null MRL+/+ mice. iNOS-null MRL+/+ mice were obtained by backcrossing iNOS-null mice (B6.129P2-Nos2tm1Lau/J) to MRL +/+ mice. Female MRL+/+ and iNOS-null MRL+/+ mice were given TCE (10 mmol/kg, i.p., every 4th day) for 6 weeks; their respective controls received corn oil only. TCE exposure led to significantly increased iNOS mRNA in livers, iNOS protein in livers and sera, increased nitrotyrosine (NT) formation in both livers and sera, induction of MDA-/HNE-protein adducts in livers and their respective antibodies in sera along with significant increases in serum antinuclear antibodies (ANA) and anti-dsDNA in MRL+/+ mice. Even though in iNOS-null MRL+/+ mice, the iNOS and NT levels were negligible in both TCE-treated and untreated groups, TCE treatment still led to significant increases in MDA-/HNE-protein adducts and their respective antibodies along with increases in serum ANA and anti-dsDNA compared to controls. Most remarkably, the increases in serum ANA and anti-dsDNA induced by TCE in the iNOS-null MRL+/+ mice were significantly less pronounced compared to that in MRL+/+ mice. Our results provide further evidence that both RNS and LDRAs contribute to TCE-induced autoimmunity in MRL+/+ mice, and iNOS deficiency attenuates this autoimmune response. PMID:26472195

  13. iNOS null MRL+/+ mice show attenuation of trichloroethene-mediated autoimmunity: contribution of reactive nitrogen species and lipid-derived reactive aldehydes.

    PubMed

    Wang, Gangduo; Wakamiya, Maki; Wang, Jianling; Ansari, G A S; Firoze Khan, M

    2015-12-01

    Earlier studies from our laboratory in MRL+/+ mice suggest that free radicals, especially overproduction of reactive nitrogen species (RNS) and lipid-derived reactive aldehydes (LDRAs), are associated with trichloroethene (TCE)-mediated autoimmune response. The current study was undertaken to further assess the contribution of RNS and LDRAs in TCE-mediated autoimmunity by using iNOS-null MRL+/+ mice. iNOS-null MRL+/+ mice were obtained by backcrossing iNOS-null mice (B6.129P2-Nos2(tm1Lau)/J) to MRL +/+ mice. Female MRL+/+ and iNOS-null MRL+/+ mice were given TCE (10 mmol/kg, i.p., every 4(th) day) for 6 weeks; their respective controls received corn oil only. TCE exposure led to significantly increased iNOS mRNA in livers, iNOS protein in livers and sera, increased nitrotyrosine (NT) formation in both livers and sera, induction of MDA-/HNE-protein adducts in livers and their respective antibodies in sera along with significant increases in serum antinuclear antibodies (ANA) and anti-dsDNA in MRL+/+ mice. Even though in iNOS-null MRL+/+ mice, the iNOS and NT levels were negligible in both TCE-treated and untreated groups, TCE treatment still led to significant increases in MDA-/HNE-protein adducts and their respective antibodies along with increases in serum ANA and anti-dsDNA compared to controls. Most remarkably, the increases in serum ANA and anti-dsDNA induced by TCE in the iNOS-null MRL+/+ mice were significantly less pronounced compared to that in MRL+/+ mice. Our results provide further evidence that both RNS and LDRAs contribute to TCE-induced autoimmunity in MRL+/+ mice, and iNOS deficiency attenuates this autoimmune response.

  14. Role of reactive oxygen species in the signalling cascade of cyclosporine A-mediated up-regulation of eNOS in vascular endothelial cells

    PubMed Central

    López-Ongil, S; Hernández-Perera, O; Navarro-Antolín, J; Pérez de Lema, G; Rodríguez-Puyol, M; Lamas, S; Rodríguez-Puyol, D

    1998-01-01

    Cyclosporine A (CsA) increases eNOS mRNA expression in bovine cultured aortic endothelial cells (BAEC). As some effects of CsA may be mediated by reactive oxygen species (ROS), present experiments were devoted to test the hypothesis that the CsA-induced eNOS up-regulation could be dependent on an increased synthesis of ROS.CsA induced a dose-dependent increase of ROS synthesis, with the two fluorescent probes used, DHR123 (CsA 1 μM: 305±7% over control) and H2DCFDA (CsA 1 μM: 178±6% over control).Two ROS generating systems, xanthine plus xanthine oxidase (XXO) and glucose oxidase (GO), increased the expression of eNOS mRNA in BAEC, an effect which was maximal after 8 h of incubation (XXO: 168±21% of control values. GO: 208±18% of control values). The ROS-dependent increased eNOS mRNA expression was followed by an increase in eNOS activity.The effect of CsA on eNOS mRNA expression was abrogated by catalase, and superoxide dismutase (SOD). In contrast, the antioxidant PDTC augmented eNOS mRNA expression, both in basal conditions and in the presence of CsA.The potential participation of the transcription factor AP-1 was explored. Electrophoretic mobility shift assays were consistent with an increase in AP-1 DNA-binding activity in BAEC treated with CsA or glucose oxidase.The present results support a role for ROS, particularly superoxide anion and hydrogen peroxide, as mediators of the CsA-induced eNOS mRNA up-regulation. Furthermore, they situate ROS as potential regulators of gene expression in endothelial cells, both in physiological and pathophysiological situations. PMID:9647467

  15. Permanent-File-Validation Utility Computer Program

    NASA Technical Reports Server (NTRS)

    Derry, Stephen D.

    1988-01-01

    Errors in files detected and corrected during operation. Permanent File Validation (PFVAL) utility computer program provides CDC CYBER NOS sites with mechanism to verify integrity of permanent file base. Locates and identifies permanent file errors in Mass Storage Table (MST) and Track Reservation Table (TRT), in permanent file catalog entries (PFC's) in permit sectors, and in disk sector linkage. All detected errors written to listing file and system and job day files. Program operates by reading system tables , catalog track, permit sectors, and disk linkage bytes to vaidate expected and actual file linkages. Used extensively to identify and locate errors in permanent files and enable online correction, reducing computer-system downtime.

  16. 75 FR 62371 - Combined Notice of Filings #2

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-08

    ... Filings 2 September 30, 2010. Take notice that the Commission received the following electric rate filings... Interconnection, L.L.C. submits tariff filing per 35.13(a)(2)(iii: ISA No. 2641, CSA Nos. 2642, 2643-T157, AES New...: Cleco Power LLC. Description: Cleco Power LLC submits tariff filing per 35.13(a)(2)(iii: RS 21...

  17. 77 FR 48133 - Combined Notice of Filings #2

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-13

    ... Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the.... Description: Compliance Filing Docket Nos. ER09-659-002 and EL12-2 Attachment O Section VII to be effective 7...)(2)(iii: Refile of Wyandotte Interconnection Agreement RS 44 to be effective 8/1/2012. Filed Date:...

  18. 16. Dry Dock No. 4. Longitudinal Section. Subdivision Nos. III ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Dry Dock No. 4. Longitudinal Section. Subdivision Nos. III and IV (Frederic R. Harris, Inc., January 10, 1941). In Files of Cushman & Wakefield, Building no. 501, Philadelphia Naval Business Center. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Dry Dock No. 4, Broad Street south of Government Avenue, Philadelphia, Philadelphia County, PA

  19. 15. Dry Dock No. 4. Longitudinal Section. Subdivision Nos. I ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. Dry Dock No. 4. Longitudinal Section. Subdivision Nos. I and II (Frederic R. Harris, Inc., January 10, 1941). In Files of Cushman & Wakefield, Building no. 501, Philadelphia Naval Business Center. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Dry Dock No. 4, Broad Street south of Government Avenue, Philadelphia, Philadelphia County, PA

  20. Langley VEDIT for NOS/VE usage manual

    NASA Technical Reports Server (NTRS)

    Heaney, Margaret A.

    1987-01-01

    The use of the VEDIT editor on the CDC Network Operating System/Virtual Environment (NOS/VE) is discussed. The VEDIT, a utility, allows a user to edit files line by line (line mode). How to access and the use of VEDIT are explained. The parameters and the format of the individual commands are defined. Examples are included.

  1. mNos2 Deletion and Human NOS2 Replacement in Alzheimer Disease Models

    PubMed Central

    Colton, Carol A.; Wilson, Joan G.; Everhart, Angela; Wilcock, Donna M.; Puoliväli, Jukka; Heikkinen, Taneli; Oksman, Juho; Jääskeläinen, Olli; Lehtimäki, Kimmo; Laitinen, Teemu; Vartiainen, Nina; Vitek, Michael P.

    2014-01-01

    Abstract Understanding the pathophysiologic mechanisms underlying Alzheimer disease relies on knowledge of disease onset and the sequence of development of brain pathologies. We present a comprehensive analysis of early and progressive changes in a mouse model that demonstrates a full spectrum of characteristic Alzheimer disease–like pathologies. This model demonstrates an altered immune redox state reminiscent of the human disease and capitalizes on data indicating critical differences between human and mouse immune responses, particularly in nitric oxide levels produced by immune activation of the NOS2 gene. Using the APPSwDI+/+/mNos2−/− (CVN-AD) mouse strain, we show a sequence of pathologic events leading to neurodegeneration,which include pathologically hyperphosphorylated tau in the perforant pathway at 6 weeks of age progressing to insoluble tau, early appearance of β-amyloid peptides in perivascular deposits around blood vessels in brain regions known to be vulnerable to Alzheimer disease, and progression to damage and overt loss in select vulnerable neuronal populations in these regions. The role of species differences between hNOS2 and mNos2 was supported by generating mice in which the human NOS2 gene replaced mNos2. When crossed with CVN-AD mice, pathologic characteristics of this new strain (APPSwDI+/−/HuNOS2tg+/+/mNos2−/−) mimicked the pathologic phenotypes found in the CVN-AD strain. PMID:25003233

  2. mNos2 deletion and human NOS2 replacement in Alzheimer disease models.

    PubMed

    Colton, Carol A; Wilson, Joan G; Everhart, Angela; Wilcock, Donna M; Puoliväli, Jukka; Heikkinen, Taneli; Oksman, Juho; Jääskeläinen, Olli; Lehtimäki, Kimmo; Laitinen, Teemu; Vartiainen, Nina; Vitek, Michael P

    2014-08-01

    Understanding the pathophysiologic mechanisms underlying Alzheimer disease relies on knowledge of disease onset and the sequence of development of brain pathologies. We present a comprehensive analysis of early and progressive changes in a mouse model that demonstrates a full spectrum of characteristic Alzheimer disease-like pathologies. This model demonstrates an altered immune redox state reminiscent of the human disease and capitalizes on data indicating critical differences between human and mouse immune responses, particularly in nitric oxide levels produced by immune activation of the NOS2 gene. Using the APPSwDI(+)/(+)mNos2(-/-) (CVN-AD) mouse strain, we show a sequence of pathologic events leading to neurodegeneration,which include pathologically hyperphosphorylated tau in the perforant pathway at 6 weeks of age progressing to insoluble tau, early appearance of β-amyloid peptides in perivascular deposits around blood vessels in brain regions known to be vulnerable to Alzheimer disease, and progression to damage and overt loss in select vulnerable neuronal populations in these regions. The role of species differences between hNOS2 and mNos2 was supported by generating mice in which the human NOS2 gene replaced mNos2. When crossed with CVN-AD mice, pathologic characteristics of this new strain (APPSwDI(+)/(-)/HuNOS2(tg+)/(+)/mNos2(-/-)) mimicked the pathologic phenotypes found in the CVN-AD strain.

  3. The NOS Challenge

    ERIC Educational Resources Information Center

    Quigley, Cassie; Buck, Gayle; Akerson, Valarie

    2011-01-01

    "The picture of a scientist is me!" exclaims first grader Kendra during a nature of science (NOS) lesson. She drew a picture of a scientist and explained that she was going to be a scientist when she grew up because she "loved to observe like a scientist." Kendra's experience was a part of a 30-day unit designed specifically for first graders.…

  4. 77 FR 24481 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-24

    .... Description: Revisions to Attachments H and T to Implement Balanced Portfolio Transfers to be effective 6/1... General Electric Company. Description: Annual Informational Filing on Operational Penalty Assessments and... Penalty Assessments and Distributions in Accordance with Order Nos. 890 and 890-A. Filed Date:...

  5. Expression of nNOS in the human larynx.

    PubMed

    Şelaru, Mircea; Rusu, Mugurel Constantin; Jianu, Adelina Maria

    2015-09-01

    Although intrinsic laryngeal neurons and ganglia have been studied in various species, they have been overlooked in humans. We aimed to investigate the presence of intrinsic laryngeal neurons in humans and, if present, to analyze their neuronal nitric oxide synthase (nNOS) expression. An immunohistochemical study using anti-nNOS antibodies was performed on samples obtained from four cadavers. Intrinsic laryngeal nNOS+ neurons were assessed in the submucosal layer, but nNOS+ nerves were found in all histological layers of the larynx. nNOS expression was also found in striated muscle fibers of larynx. This might reveal the anatomical basis of an upwards extension of the nonadrenergic noncholinergic system in human airways, but further experiments are needed to assess an exact role of NO influence on neural transmission and muscular functions of human larynx.

  6. Nitric oxide synthase (NOS) in the Japanese fireflies Luciola lateralis and Luciola cruciata.

    PubMed

    Ohtsuki, Hajime; Yokoyama, Jun; Ohba, Nobuyoshi; Ohmiya, Yoshihiro; Kawata, Masakado

    2008-12-01

    Species-specific flash patterns in firefly species are important for the investigation of the evolution of Lampyridae. Since nitric oxide synthase (NOS) is one of the key enzymes controlling flash patterns, we determined the cDNA sequences of NOS in the Japanese fireflies Luciola lateralis and L. cruciata. The identity of the NOS sequences was very high between these 2 species. Firefly NOS also exhibited a high identity with those of other insect species, and the cofactor-binding domains were particularly well conserved. Many negatively selected sites were detected throughout the NOS sequences; however, no positive selection was detected. The phylogenetic relationship of insect NOS was different from that of the general classification system, although the lineages corresponded to the major recognized taxonomic groups.

  7. 75 FR 23242 - Marine Mammals; File Nos. 15498 and 15500

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-03

    ..., Atlanta, GA 30313, have each applied in due form for a permit to import Atlantic bottlenose dolphins... female captive born bottlenose dolphin from Dolphin Quest Bermuda, Hamilton, Bermuda, to the Brookfield... dolphins from Dolphin Experience, Ltd., Freeport, Grand Bahama Island, The Bahamas, and three...

  8. 77 FR 64959 - Marine Mammals; File Nos. 15777 and 17670

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-24

    ... seals (Halichoerus grypus), harp seals (Pagophilus groenlandicus), and hooded seals (Cystophora cristata..., hair, swab samples, vibrissae), and attachment of telemetry devices. Up to 200 harp seals, 50 hooded... seals, 8 harbor seals, 2 harp seals, and 2 hooded seals per year. Permission is also sought to...

  9. 78 FR 21112 - Marine Mammals; File Nos. 16992 and 14535

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-09

    ..., Ph.D., Hawaii Institute of Marine Biology, University of Hawaii, P.O. Box 1106, Kailua, HI 96734, has... of Marine Biology in Kaneohe, HI. Researchers would conduct hearing measurements using suction...

  10. 78 FR 60852 - Marine Mammals; File Nos. 16239 and 17312

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ... issued to Dan Engelhaupt, Ph.D., HDR EOC, 5700 Lake Wright Drive, Norfolk, VA 23502- 1859, and Scripps Institution of Oceanography [Responsible Party: John Hildebrand, Ph.D.], University of California,...

  11. 75 FR 37389 - Marine Mammals; File Nos. 14628 and 15471

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-29

    ... purposes:National Museum of Natural History, Smithsonian Institution (Charles W. Potter, Responsible Party... Museum of Natural History (NMNH) is requesting authorization to collect, import, export, possess,...

  12. Compress Your Files

    ERIC Educational Resources Information Center

    Branzburg, Jeffrey

    2005-01-01

    File compression enables data to be squeezed together, greatly reducing file size. Why would someone want to do this? Reducing file size enables the sending and receiving of files over the Internet more quickly, the ability to store more files on the hard drive, and the ability pack many related files into one archive (for example, all files…

  13. 76 FR 45232 - Marine Mammals; File No. 16443

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-28

    ... National Oceanic and Atmospheric Administration RIN 0648-XA597 Marine Mammals; File No. 16443 AGENCY... Applications and Permits for Protected Species home page, https://apps.nmfs.noaa.gov , and then selecting File... . Please include File No. 16433 in the subject line of the e-mail comment. Those individuals requesting...

  14. 77 FR 268 - Marine Mammals; File No. 16998

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-04

    ... National Oceanic and Atmospheric Administration RIN 0648-XA914 Marine Mammals; File No. 16998 AGENCY... Permits for Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No...-0376, or by email to NMFS.Pr1Comments@noaa.gov . Please include the File No. in the subject line of...

  15. 78 FR 53732 - Marine Mammals; File No. 14325

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-30

    ... National Oceanic and Atmospheric Administration RIN 0648-XC010 Marine Mammals; File No. 14325 AGENCY... Applications and Permits for Protected Species home page, https://apps.nmfs.noaa.gov , and then selecting File...-0376, or by email to NMFS.Pr1Comments@noaa.gov . Please include the File No. in the subject line of...

  16. 77 FR 40859 - Marine Mammals; File No. 14097

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-11

    ... National Oceanic and Atmospheric Administration RIN 0648-XX47 Marine Mammals; File No. 14097 AGENCY... Applications and Permits for Protected Species home page, https://apps.nmfs.noaa.gov , and then selecting File....Pr1Comments@noaa.gov . Please include the File No. in the subject line of the email comment. Those...

  17. 78 FR 66336 - Marine Mammals; File No. 17030

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-05

    ... National Oceanic and Atmospheric Administration RIN 0648-XC956 Marine Mammals; File No. 17030 AGENCY... Permits for Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No... submitted by facsimile to (301)713-0376, or by email to NMFS.Pr1Comments@noaa.gov . Please include File...

  18. 77 FR 27441 - Marine Mammals; File No. 13927

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-10

    ... National Oceanic and Atmospheric Administration RIN 0648-XA774 Marine Mammals; File No. 13927 AGENCY... Permits for Protected Species home page, https://apps.nmfs.noaa.gov , and then selecting File No. 13927...-0376, or by email to NMFS.Pr1Comments@noaa.gov . Please include the File No. in the subject line of...

  19. 75 FR 39915 - Marine Mammals; File No. 15483

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-13

    ... National Oceanic and Atmospheric Administration RIN 0648-XX23 Marine Mammals; File No. 15483 AGENCY... Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No. 15483 from the... include the File No. in the subject line of the email comment. Those individuals requesting a...

  20. 75 FR 9201 - DCP Raptor Pipeline, LLC; Notice of Compliance Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-01

    ... Energy Regulatory Commission DCP Raptor Pipeline, LLC; Notice of Compliance Filing February 22, 2010. Take notice that on January 28, 2010, DCP Raptor Pipeline, LLC (Raptor) filed its Statement of... Docket Nos. PR09-32-000 and PR09-32-001. Raptor states that it made revisions to include a statement...

  1. Common File Formats.

    PubMed

    Mills, Lauren

    2014-03-21

    An overview of the many file formats commonly used in bioinformatics and genome sequence analysis is presented, including various data file formats, alignment file formats, and annotation file formats. Example workflows illustrate how some of the different file types are typically used.

  2. Morphological and genetic variation in North Atlantic giant file clams, Acesta spp. (Bivalvia: Limidae), with description of a new cryptic species in the northwest Atlantic.

    PubMed

    Gagnon, Jean-Marc; Kenchington, Ellen; Port, Antony; Anstey, Lynne J; Murillo, Francisco Javier

    2015-08-27

    We analyze the morphological and genetic variability within and between seven species of Acesta and specimens recently collected in the northwest Atlantic using traditional morphological measurements, landmark-based geometric morphometrics, and the cytochrome oxidase subunit I (COI) gene sequences, with particular emphasis on North Atlantic species. Shell morphology and external shell appearance do not allow reliable distinction between the widely recognized northeastern Atlantic A. excavata and other northwest Atlantic species or populations of Acesta, with the exception of A. oophaga. Similarly, shape analysis reveals a wide variability within northeastern Atlantic A. excavata, and significant morphological overlap with A. bullisi from the Gulf of Mexico and A. rathbuni from the southwestern Pacific and South China Sea. Specimens from the northwestern and Mid-Atlantic display shell shapes marginally similar to that of A. excavata. These differences are at least partly related to anterior or posterior shifting of the shell body and to the opposite shifting of the hinge line/dorsal region and upper lunule. These morphological variations, along with the midline-width-ratio, explain much of the variability extracted by principal component analysis. Results from a mitochondrial DNA barcode approach (COI), however, suggest that the northwest Atlantic specimens belong to a new species for which we propose the name Acesta cryptadelphe sp. nov. Differences in larval shell sizes between northeastern and northwestern Atlantic specimens are consistent with this result.

  3. 43 CFR 4.1352 - Who may file; where to file; when to file.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Who may file; where to file; when to file... Indian Lands) § 4.1352 Who may file; where to file; when to file. (a) The applicant or operator may file... to file a timely request constitutes a waiver of the opportunity for a hearing before OSM makes...

  4. 75 FR 70229 - Combined Notice of Filings No. 2

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-17

    ..., November 17, 2010. Docket Numbers: RP10-1037-001. Applicants: Granite State Gas Transmission, Inc. Description: Granite State Gas Transmission, Inc. Filing Addressing Compliance Obligations in Docket Nos. RP10..., 2010. Docket Numbers: RP10-963-002. Applicants: Granite State Gas Transmission, Inc....

  5. NOS1 — EDRN Public Portal

    Cancer.gov

    NOS1, or nitric oxide synthase 1 (neuronal), along with inducible nitric oxide synthase (NOS2) and endothelial nitric oxide synthase (NOS3), catalyze the generation of nitric oxide and L-citrulline from L-arginine and molecular oxygen. Nitric oxide is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter. NOS1 also displays antimicrobial and antitumoral activities.

  6. 77 FR 1924 - Middlebury Electric, LLC; Notice of Intent To File License Application, Filing of Pre-Application...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-12

    .... b. Project Nos.: P-13235-002 and P-13355-001. c. Dates Filed: May 5, 2011, and June 20, 2011.... Potential Applicant Contact: Alders Holm, Middlebury Electric, LLC, 5 Frog Hollow Alley, Middlebury, VT... 402; (b) NOAA Fisheries under section 305(b) of the Magnuson-Stevens Fishery Conservation...

  7. 78 FR 24458 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-25

    ... route orders in options listed and open for trading to destination markets. Each time NOS routes to away... markets have a common data center and staff that are responsible for the day-to-day operations of NOS... COMMISSION Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing and Immediate...

  8. Comparison of oxygen-induced radical intermediates in iNOS oxygenase domain with those from nNOS and eNOS.

    PubMed

    Berka, Vladimír; Liu, Wen; Wu, Gang; Tsai, Ah-Lim

    2014-10-01

    Inducible nitric-oxide synthase (iNOS) produces the reactive oxygen and nitrogen species (ROS/RNS) involved in bacteria killing and is crucial in the host defense mechanism. However, high level ROS/RNS can also be detrimental to normal cells and thus their production has to be tightly controlled. Availability or deficiency of tetrahydrobiopterin (BH4) cofactor and l-arginine substrate controls coupling or uncoupling of NOS catalysis. Fully coupled reaction, with abundant BH4 and l-arginine, produces NO whereas the uncoupled NOS (in the absence of BH4 and/or l-arginine) generates ROS/RNS. In the current work we focus on direct rapid freeze EPR to characterize the structure and kinetics of oxygen-induced radical intermediates produced by ferrous inducible NOS oxygenase domain (iNOSox) in the presence or absence of BH4 and/or l-arginine. Fully reconstituted iNOSox (+BH4, +L-Arg) forms a dimer and yields a typical BH4 radical that indicates coupled reaction. iNOSox (-BH4) remains mainly monomeric and produces exclusively superoxide, that is only marginally affected by the presence of l-arginine. iNOSox (+BH4, -L-Arg) exists as a monomer/dimer mixture and yields both BH4 radical and superoxide. Present study is a natural extension of our previous work on the ferrous endothelial NOSox (eNOSox) [V. Berka, G. Wu, H.C. Yeh, G. Palmer, A.L. Tsai, J. Biol. Chem. 279 (2004) 32243-32251] and ferrous neuronal NOSox (nNOSox) [V. Berka, L.H. Wang, A.L. Tsai, Biochemistry 47 (2008) 405-420]. Overall, our data suggests different regulatory roles of l-arginine and BH4 in the production of oxygen-induced radical intermediates in NOS isoforms which nicely serve individual functional role.

  9. 78 FR 19791 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-02

    ... route orders in options listed and open for trading to destination markets. Each time NOS routes to away... COMMISSION Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate... that on March 19, 2013, The NASDAQ Stock Market LLC (``NASDAQ'' or ``Exchange'') filed with...

  10. 78 FR 41176 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-09

    ... Exchange Act Release Nos. 68460 (December 18, 2012), 77 FR 76145 (December 26, 2012) (SR-NYSEMKT-2012-41) (approval order) (``NYSE MKT filing''); 68461 (December 18, 2012), 77 FR 76155 (December 26, 2012) (SR-NYSEArca-2012-94) (approval order) (``NYSE Arca filing''); and 68606 (January 9, 2013), 78 FR 3065...

  11. 78 FR 48734 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    ...\\ See Securities Exchange Act Release Nos. 68460 (December 18, 2012), 77 FR 76145 (December 26, 2012) (SR-NYSEMKT-2012-41) (approval order) (``NYSE MKT filing''); 68461 (December 18, 2012), 77 FR 76155...), 78 FR 3065 (January 15, 2013) (SR-CBOE-2012-131) (notice of filing and immediate...

  12. 78 FR 48744 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    ... standard (monthly) option. \\4\\ See Securities Exchange Act Release Nos. 68460 (December 18, 2012), 77 FR... 18, 2012), 77 FR 76155 (December 26, 2012) (SR-NYSEArca-2012-94) (approval order) (``NYSE Arca filing''); 68606 (January 9, 2013), 78 FR 3065 (January 15, 2013) (SR-CBOE-2012-131) (notice of filing...

  13. 76 FR 74109 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-30

    .... See Securities Exchange Act Release No. 62252 (June 10, 2010), 75 FR 34186 (June 16, 2010) (File Nos...-CBOE- 2010-047), and Securities Exchange Act Release No. 62251 (June 10, 2010), 75 FR 34183 (June 16... Securities Exchange Act Release No. 62884 (September 10, 2010), 75 FR 56618 (September 16, 2010) (File...

  14. 43 CFR 4.1381 - Who may file; when to file; where to file.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Who may file; when to file; where to file... may file; when to file; where to file. (a) Any person who receives a written decision issued by OSM under 30 CFR 773.28 on a challenge to an ownership or control listing or finding may file a request...

  15. Reversal of SIN-1-induced eNOS dysfunction by the spin trap, DMPO, in bovine aortic endothelial cells via eNOS phosphorylation

    PubMed Central

    Das, Amlan; Gopalakrishnan, Bhavani; Druhan, Lawrence J; Wang, Tse-Yao; De Pascali, Francesco; Rockenbauer, Antal; Racoma, Ira; Varadharaj, Saradhadevi; Zweier, Jay L; Cardounel, Arturo J; Villamena, Frederick A

    2014-01-01

    Background and Purpose Nitric oxide (NO) derived from eNOS is mostly responsible for the maintenance of vascular homeostasis and its decreased bioavailability is characteristic of reactive oxygen species (ROS)-induced endothelial dysfunction (ED). Because 5,5-dimethyl-1-pyrroline-N-oxide (DMPO), a commonly used spin trap, can control intracellular nitroso-redox balance by scavenging ROS and donating NO, it was employed as a cardioprotective agent against ED but the mechanism of its protection is still not clear. This study elucidated the mechanism of protection by DMPO against SIN-1-induced oxidative injury to bovine aortic endothelial cells (BAEC). Experimental Approach BAEC were treated with SIN-1, as a source of peroxynitrite anion (ONOO−), and then incubated with DMPO. Cytotoxicity following SIN-1 alone and cytoprotection by adding DMPO was assessed by MTT assay. Levels of ROS and NO generation from HEK293 cells transfected with wild-type and mutant eNOS cDNAs, tetrahydrobiopterin bioavailability, eNOS activity, eNOS and Akt kinase phosphorylation were measured. Key Results Post-treatment of cells with DMPO attenuated SIN-1-mediated cytotoxicity and ROS generation, restoration of NO levels via increased in eNOS activity and phospho-eNOS levels. Treatment with DMPO alone significantly increased NO levels and induced phosphorylation of eNOS Ser1179 via Akt kinase. Transfection studies with wild-type and mutant human eNOS confirmed the dual role of eNOS as a producer of superoxide anion (O2−) with SIN-1 treatment, and a producer of NO in the presence of DMPO. Conclusion and Implications Post-treatment with DMPO of oxidatively challenged cells reversed eNOS dysfunction and could have pharmacological implications in the treatment of cardiovascular diseases. PMID:24405159

  16. The return of the Scarlet Pimpernel: cobalamin in inflammation II — cobalamins can both selectively promote all three nitric oxide synthases (NOS), particularly iNOS and eNOS, and, as needed, selectively inhibit iNOS and nNOS

    PubMed Central

    Wheatley, Carmen

    2007-01-01

    The up-regulation of transcobalamins [hitherto posited as indicating a central need for cobalamin (Cbl) in inflammation], whose expression, like inducible nitric oxide synthase (iNOS), is Sp1- and interferondependent, together with increased intracellular formation of glutathionylcobalamin (GSCbl), adenosylcobalamin (AdoCbl), methylcobalamin (MeCbl), may be essential for the timely promotion and later selective inhibition of iNOS and concordant regulation of endothelial and neuronal NOS (eNOS/nNOS.) Cbl may ensure controlled high output of nitric oxide (NO) and its safe deployment, because: (1) Cbl is ultimately responsible for the synthesis or availability of the NOS substrates and cofactors heme, arginine, BH4 flavin adenine dinucleotide/flavin mononucleotide (FAD/FMN) and NADPH, via the far-reaching effects of the two Cbl coenzymes, methionine synthase (MS) and methylmalonyl CoA mutase (MCoAM) in, or on, the folate, glutathione, tricarboxylic acid (TCA) and urea cycles, oxidative phosphorylation, glycolysis and the pentose phosphate pathway. Deficiency of any of theNOS substrates and cofactors results in ‘uncoupled’ NOS reactions, decreasedNO production and increased or excessive O2−, H2O2, ONOO− and other reactive oxygen species (ROS), reactive nitric oxide species (RNIS) leading to pathology. (2) Cbl is also the overlooked ultimate determinant of positive glutathione status, which favours the formation of more benign NO species, s-nitrosothiols, the predominant form in which NO is safely deployed. Cbl status may consequently act as a ‘back-up disc’ that ensures the active status of antioxidant systems, as well as reversing and modulating the effects of nitrosylation in cell signal transduction.New evidence shows that GSCbl can significantly promote iNOS/ eNOS NO synthesis in the early stages of inflammation, thus lowering high levels of tumour necrosis factor-a that normally result in pathology, while existing evidence shows that in extreme

  17. Expression profiles of NOS isoforms in gingiva of nNOS knockout mice.

    PubMed

    Ishioka, M; Ishizuka, Y; Shintani, S; Yanagisawa, T; Inoue, T; Sasaki, J; Watanabe, H

    2014-04-01

    Nitric oxide is a gaseous molecule associated with many distinct physiological functions, and is derived from L-arginine catalyzed by nitric oxide synthase (NOS). Nitric oxide synthase has 3 isoforms: nNOS, iNOS and eNOS. Although these NOS isoforms are believed to play an important role in gingival tissue, little information is available on their morphological dynamics. The aim of this study was to investigate the profiles of NOS isoforms in deficiency of nNOS in gingiva of mice. Twelve male (6 normal (C57BL/6) and 6 nNOS knockout) mice were used. All mice were 5-week-old, weighing approximately 20-25 g each. After sacrifice, the jaws of the mice were removed by mechanical means and specimens analyzed by histology, in situ hybridization and immunohistochemistry. Immunohistochemical observation revealed positive staining for iNOS and eNOS, especially in lamina propria. Similar results in the mRNA expression levels were shown by in situ hybridization analysis. It may suggest that iNOS and eNOS compensated nNOS deficiency in the gingiva of nNOS knockout mice.

  18. Nox2-dependent glutathionylation of endothelial NOS leads to uncoupled superoxide production and endothelial barrier dysfunction in acute lung injury.

    PubMed

    Wu, Feng; Szczepaniak, William S; Shiva, Sruti; Liu, Huanbo; Wang, Yinna; Wang, Ling; Wang, Ying; Kelley, Eric E; Chen, Alex F; Gladwin, Mark T; McVerry, Bryan J

    2014-12-15

    Microvascular barrier integrity is dependent on bioavailable nitric oxide (NO) produced locally by endothelial NO synthase (eNOS). Under conditions of limited substrate or cofactor availability or by enzymatic modification, eNOS may become uncoupled, producing superoxide in lieu of NO. This study was designed to investigate how eNOS-dependent superoxide production contributes to endothelial barrier dysfunction in inflammatory lung injury and its regulation. C57BL/6J mice were challenged with intratracheal LPS. Bronchoalveolar lavage fluid was analyzed for protein accumulation, and lung tissue homogenate was assayed for endothelial NOS content and function. Human lung microvascular endothelial cell (HLMVEC) monolayers were exposed to LPS in vitro, and barrier integrity and superoxide production were measured. Biopterin species were quantified, and coimmunoprecipitation (Co-IP) assays were performed to identify protein interactions with eNOS that putatively drive uncoupling. Mice exposed to LPS demonstrated eNOS-dependent increased alveolar permeability without evidence for altered canonical NO signaling. LPS-induced superoxide production and permeability in HLMVEC were inhibited by the NOS inhibitor nitro-l-arginine methyl ester, eNOS-targeted siRNA, the eNOS cofactor tetrahydrobiopterin, and superoxide dismutase. Co-IP indicated that LPS stimulated the association of eNOS with NADPH oxidase 2 (Nox2), which correlated with augmented eNOS S-glutathionylation both in vitro and in vivo. In vitro, Nox2-specific inhibition prevented LPS-induced eNOS modification and increases in both superoxide production and permeability. These data indicate that eNOS uncoupling contributes to superoxide production and barrier dysfunction in the lung microvasculature after exposure to LPS. Furthermore, the results implicate Nox2-mediated eNOS-S-glutathionylation as a mechanism underlying LPS-induced eNOS uncoupling in the lung microvasculature.

  19. 77 FR 36999 - Marine Mammals; File No. 16160

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-20

    ... 0648-XA626 Marine Mammals; File No. 16160 AGENCY: National Marine Fisheries Service (NMFS), National... Permits for Protected Species home page, https://apps.nmfs.noaa.gov , and then selecting File No. 16160... submitted by facsimile to (301) 713-0376, or by email to NMFS.Pr1Comments@noaa.gov . Please include the...

  20. Vascular and Perivascular NO Release and Transport: Biochemical Pathways of NOS1 and NOS3

    PubMed Central

    Chen, Kejing; Popel, Aleksander S.

    2007-01-01

    Nitric oxide (NO) derived from nitric oxide synthase (NOS) is an important paracrine effector that maintains vascular tone. The release of NO mediated by NOS isozymes under various O2 conditions critically determines the NO bioavailability in tissues. Because of experimental difficulties, there has been no direct information on how enzymatic NO production and distribution change around arterioles under various oxygen conditions. In this study, we used computational models based on the analysis of biochemical pathways of enzymatic NO synthesis and the availability of NOS isozymes to quantify the NO production by neuronal NOS (NOS1) and endothelial NOS (NOS3). We compared the catalytic activities of NOS1 and NOS3 and their sensitivities to the concentration of substrate O2. Based on the NO release rates predicted from kinetic models, the geometric distribution of NO sources and mass balance analysis, we predicted the NO concentration profiles around an arteriole under various O2 conditions. The results indicated that NOS1-catalyzed NO production was significantly more sensitive to ambient O2 concentration than that catalyzed by NOS3. Also, the high sensitivity of NOS1 catalytic activity to O2 was associated with significantly reduced NO production and therefore NO concentrations, upon hypoxia. Moreover, the major source determining the distribution of NO was NOS1, which was abundantly expressed in the nerve fibers and mast cells close to arterioles, rather than NOS3, which was expressed in the endothelium. Finally, the perivascular NO concentration predicted by the models under conditions of normoxia was paradoxically at least an order of magnitude lower than a number of experimental measurements, suggesting a higher abundance of NOS1 or NOS3 and/or the existence of other enzymatic or non-enzymatic sources of NO in the microvasculature. PMID:17320763

  1. 21 CFR 516.163 - Change in ownership of an index file.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Change in ownership of an index file. 516.163... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS NEW ANIMAL DRUGS FOR MINOR USE AND MINOR SPECIES Index... index file. (a) A holder may transfer ownership of a drug's index file to another person. (1) The...

  2. 21 CFR 516.163 - Change in ownership of an index file.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 6 2011-04-01 2011-04-01 false Change in ownership of an index file. 516.163... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS NEW ANIMAL DRUGS FOR MINOR USE AND MINOR SPECIES Index... index file. (a) A holder may transfer ownership of a drug's index file to another person. (1) The...

  3. Standard interface file handbook

    SciTech Connect

    Shapiro, A.; Huria, H.C. )

    1992-10-01

    This handbook documents many of the standard interface file formats that have been adopted by the US Department of Energy to facilitate communications between and portability of, various large reactor physics and radiation transport software packages. The emphasis is on those files needed for use of the VENTURE/PC diffusion-depletion code system. File structures, contents and some practical advice on use of the various files are provided.

  4. Text File Display Program

    NASA Technical Reports Server (NTRS)

    Vavrus, J. L.

    1986-01-01

    LOOK program permits user to examine text file in pseudorandom access manner. Program provides user with way of rapidly examining contents of ASCII text file. LOOK opens text file for input only and accesses it in blockwise fashion. Handles text formatting and displays text lines on screen. User moves forward or backward in file by any number of lines or blocks. Provides ability to "scroll" text at various speeds in forward or backward directions.

  5. Text File Comparator

    NASA Technical Reports Server (NTRS)

    Kotler, R. S.

    1983-01-01

    File Comparator program IFCOMP, is text file comparator for IBM OS/VScompatable systems. IFCOMP accepts as input two text files and produces listing of differences in pseudo-update form. IFCOMP is very useful in monitoring changes made to software at the source code level.

  6. Bioinformatic comparisons and tissue expression of the neuronal nitric oxide synthase (nNOS) gene from the red drum (Sciaenops ocellatus).

    PubMed

    Zhou, Libin; Bai, Ru; Tian, Jianxiao; Liu, Xiaochun; Lu, Danqi; Zhu, Pei; Liu, Yun; Zeng, Lujiao; Luo, Wenna; Zhang, Yong; Wang, Anli

    2009-10-01

    The full length cDNA sequence for neuronal nitric oxide synthase (nNOS) gene from red drum (Sciaenops ocellatus) has been cloned, subjected to bioinformatic analysis, and examined for expression in different tissues. Red drum nNOS showed high identity to nNOS of mammals and other fish species. Notably, a unique 7-aa insertion was found in the important catalytic sites of the NO synthase domain, possibly affecting the function of red drum nNOS. Furthermore, this nNOS was expressed not only in brain but also in most of the internal organs including liver, intestine, spleen, head kidney and thymus.

  7. 76 FR 49736 - Marine Mammals; File No. 15471-01

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-11

    ... Adkesson, D.V.M., Chicago Zoological Society, 3300 Golf Rd., Brookfield, Illinois 60527, has applied for an... and Permits for Protected Species home page, https://apps.nmfs.noaa.gov , and then selecting File...

  8. 77 FR 48967 - Marine Mammals; File No. 17350

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-15

    ... marine mammals of the following species: bearded seal (Erignathus ] barbatus), ringed seal (Phoca hispida... National Oceanic and Atmospheric Administration RIN 0648-XC067 Marine Mammals; File No. 17350 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration (NOAA),...

  9. 43 CFR 4.1371 - Who may file, where to file, when to file.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Who may file, where to file, when to file... Permits § 4.1371 Who may file, where to file, when to file. (a) A permittee that is served with a notice... under 30 CFR 773.23 may file a request for review with the Hearings Division, Office of Hearings...

  10. 21 CFR 516.147 - Refuse to file a request for addition to the index.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 6 2014-04-01 2014-04-01 false Refuse to file a request for addition to the index. 516.147 Section 516.147 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... SPECIES Index of Legally Marketed Unapproved New Animal Drugs for Minor Species § 516.147 Refuse to file...

  11. 21 CFR 516.171 - Confidentiality of data and information in an index file.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... index file. 516.171 Section 516.171 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH... USE AND MINOR SPECIES Index of Legally Marketed Unapproved New Animal Drugs for Minor Species § 516.171 Confidentiality of data and information in an index file. (a) For purposes of this section,...

  12. 21 CFR 516.147 - Refuse to file a request for addition to the index.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Refuse to file a request for addition to the index. 516.147 Section 516.147 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... SPECIES Index of Legally Marketed Unapproved New Animal Drugs for Minor Species § 516.147 Refuse to file...

  13. 21 CFR 516.147 - Refuse to file a request for addition to the index.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 6 2011-04-01 2011-04-01 false Refuse to file a request for addition to the index. 516.147 Section 516.147 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... SPECIES Index of Legally Marketed Unapproved New Animal Drugs for Minor Species § 516.147 Refuse to file...

  14. 21 CFR 516.171 - Confidentiality of data and information in an index file.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... index file. 516.171 Section 516.171 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH... USE AND MINOR SPECIES Index of Legally Marketed Unapproved New Animal Drugs for Minor Species § 516.171 Confidentiality of data and information in an index file. (a) For purposes of this section,...

  15. 21 CFR 516.147 - Refuse to file a request for addition to the index.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 6 2013-04-01 2013-04-01 false Refuse to file a request for addition to the index. 516.147 Section 516.147 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... SPECIES Index of Legally Marketed Unapproved New Animal Drugs for Minor Species § 516.147 Refuse to file...

  16. 21 CFR 516.147 - Refuse to file a request for addition to the index.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 6 2012-04-01 2012-04-01 false Refuse to file a request for addition to the index. 516.147 Section 516.147 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... SPECIES Index of Legally Marketed Unapproved New Animal Drugs for Minor Species § 516.147 Refuse to file...

  17. 21 CFR 516.171 - Confidentiality of data and information in an index file.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... index file. 516.171 Section 516.171 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH... USE AND MINOR SPECIES Index of Legally Marketed Unapproved New Animal Drugs for Minor Species § 516.171 Confidentiality of data and information in an index file. (a) For purposes of this section,...

  18. XML Files: MedlinePlus

    MedlinePlus

    ... Topic Group XML (11 K) ( DTD , 3 K) Definitions of Health Terms These files contain English definitions of health terms. The files contain health terms definitions NIH sources for the definitions These files are ...

  19. Sensitivity Data File Formats

    SciTech Connect

    Rearden, Bradley T.

    2016-04-01

    The format of the TSUNAMI-A sensitivity data file produced by SAMS for cases with deterministic transport solutions is given in Table 6.3.A.1. The occurrence of each entry in the data file is followed by an identification of the data contained on each line of the file and the FORTRAN edit descriptor denoting the format of each line. A brief description of each line is also presented. A sample of the TSUNAMI-A data file for the Flattop-25 sample problem is provided in Figure 6.3.A.1. Here, only two profiles out of the 130 computed are shown.

  20. Register file soft error recovery

    DOEpatents

    Fleischer, Bruce M.; Fox, Thomas W.; Wait, Charles D.; Muff, Adam J.; Watson, III, Alfred T.

    2013-10-15

    Register file soft error recovery including a system that includes a first register file and a second register file that mirrors the first register file. The system also includes an arithmetic pipeline for receiving data read from the first register file, and error detection circuitry to detect whether the data read from the first register file includes corrupted data. The system further includes error recovery circuitry to insert an error recovery instruction into the arithmetic pipeline in response to detecting the corrupted data. The inserted error recovery instruction replaces the corrupted data in the first register file with a copy of the data from the second register file.

  1. 11 CFR 100.19 - File, filed or filing (2 U.S.C. 434(a)).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... file electronically under 11 CFR 104.18, may file 24-hour reports using the Commission's website's on..., including electronic reporting entities, may use the Commission's website's on-line program to file...

  2. Multifaceted NOS Instruction: Contextualizing Nature of Science with Documentary Films

    ERIC Educational Resources Information Center

    Bloom, Mark; Binns, Ian C.; Koehler, Catherine

    2015-01-01

    This research focuses on inservice science teachers' conceptions of nature of science (NOS) before and after a two-week intensive summer professional development (PD). The PD combined traditional explicit NOS instruction, numerous interactive interventions that highlighted NOS aspects, along with documentary films that portrayed NOS in context of…

  3. JENDL Dosimetry File 99.

    SciTech Connect

    KEIICHI,; SHIBATA,

    2001-01-22

    Version 00 JENDL/D-99 contains information for 47 nuclides and 67 reactions in the SAND-II group structure (although it was observed by RSICC that not all of the processed files are in the SAND-II group structure) and as 0K preprocessed pointwise files.

  4. Viewing Files | Smokefree 60+

    Cancer.gov

    In addition to standard HTML webpages, our website contains files in other formats. You may need additional software or browser plug-ins to view some of these files. The following list shows each format along with links to the corresponding freely available plug-ins or viewers. Documents  Adobe Acrobat Reader (.pdf)

  5. Carbon monoxide increases inducible NOS expression that mediates CO-induced myocardial damage during ischemia-reperfusion.

    PubMed

    Meyer, Grégory; André, Lucas; Kleindienst, Adrien; Singh, François; Tanguy, Stéphane; Richard, Sylvain; Obert, Philippe; Boucher, François; Jover, Bernard; Cazorla, Olivier; Reboul, Cyril

    2015-04-01

    We investigated the role of inducible nitric oxide (NO) synthase (iNOS) on ischemic myocardial damage in rats exposed to daily low nontoxic levels of carbon monoxide (CO). CO is a ubiquitous environmental pollutant that impacts on mortality and morbidity from cardiovascular diseases. We have previously shown that CO exposure aggravates myocardial ischemia-reperfusion (I/R) injury partly because of increased oxidative stress. Nevertheless, cellular mechanisms underlying cardiac CO toxicity remain hypothetical. Wistar rats were exposed to simulated urban CO pollution for 4 wk. First, the effects of CO exposure on NO production and NO synthase (NOS) expression were evaluated. Myocardial I/R was performed on isolated perfused hearts in the presence or absence of S-methyl-isothiourea (1 μM), a NOS inhibitor highly specific for iNOS. Finally, Ca(2+) handling was evaluated in isolated myocytes before and after an anoxia-reoxygenation performed with or without S-methyl-isothiourea or N-acetylcystein (20 μM), a nonspecific antioxidant. Our main results revealed that 1) CO exposure altered the pattern of NOS expression, which is characterized by increased neuronal NOS and iNOS expression; 2) cardiac NO production increased in CO rats because of its overexpression of iNOS; and 3) the use of a specific inhibitor of iNOS reduced myocardial hypersensitivity to I/R (infarct size, 29 vs. 51% of risk zone) in CO rat hearts. These last results are explained by the deleterious effects of NO and reactive oxygen species overproduction by iNOS on diastolic Ca(2+) overload and myofilaments Ca(2+) sensitivity. In conclusion, this study highlights the involvement of iNOS overexpression in the pathogenesis of simulated urban CO air pollution exposure.

  6. 29 CFR 4007.3 - Filing requirement; method of filing.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Filing requirement; method of filing. 4007.3 Section 4007.3 Labor Regulations Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION PREMIUMS PAYMENT OF PREMIUMS § 4007.3 Filing requirement; method of filing. (a) In general. The estimation, determination, declaration, and payment of...

  7. Catalytic Promiscuity of the Radical S-adenosyl-L-methionine Enzyme NosL

    PubMed Central

    Ding, Wei; Ji, Xinjian; Li, Yongzhen; Zhang, Qi

    2016-01-01

    Catalytic promiscuity plays a key role in enzyme evolution and the acquisition of novel biological functions. Because of the high reactivity of radical species, in our view enzymes involving radical-mediated mechanisms could intrinsically be more prone to catalytic promiscuity. This mini-review summarizes the recent advances in the study of NosL, a radical S-adenosyl-L-methionine (SAM)-dependent L-tryptophan (L-Trp) lyase. We demonstrate here the interesting chemistry and remarkable catalytic promiscuity of NosL, and attempt to highlight the high evolvability of radical SAM enzymes and the potential to engineer these enzymes for novel and improved activities. PMID:27446906

  8. Construction of file database management

    SciTech Connect

    MERRILL,KYLE J.

    2000-03-01

    This work created a database for tracking data analysis files from multiple lab techniques and equipment stored on a central file server. Experimental details appropriate for each file type are pulled from the file header and stored in a searchable database. The database also stores specific location and self-directory structure for each data file. Queries can be run on the database according to file type, sample type or other experimental parameters. The database was constructed in Microsoft Access and Visual Basic was used for extraction of information from the file header.

  9. Selective File Dumper

    NASA Astrophysics Data System (ADS)

    Bassetti, Nanni; Frati, Denis

    During a computer forensics investigation we faced a problem how to get all the interesting files we need fast. We work, mainly, using the Open Source software products and Linux OS, and we consider the Sleuthkit and the Foremost two very useful tools, but for reaching our target they were too complicated and time consuming to use. For this reason we developed the Selective File Dumper, a Linux Bash script which makes it possible to extract all the referenced, deleted and unallocated files and finally to perform a keyword search, in a simple way.

  10. MAWST file generator (MFG)

    SciTech Connect

    Henriksen, P.W.; Hurdle, S.; Hafer, J.F.

    1993-12-01

    The software program MAWST was developed as a tool to deal with common materials accounting problems. The key to successful usage of this program is in the generation of input files for measurement values, measurement errors, and measurement methods. The program MFG was developed as an aid to creating input files for MAWST. MFG contains three commonly used measurements -- nondestructive assay, (G-T)*C, and V*C -- and a GENERIC measurement as models for data entry for the measurement value file. Sufficient data is collected from the user to produce the measurement error and measurement method files. This report is written as a tutorial presenting and explaining all the options available in MFG by giving examples of execution and the resulting screens that MFG produces.

  11. Converting CSV Files to RKSML Files

    NASA Technical Reports Server (NTRS)

    Trebi-Ollennu, Ashitey; Liebersbach, Robert

    2009-01-01

    A computer program converts, into a format suitable for processing on Earth, files of downlinked telemetric data pertaining to the operation of the Instrument Deployment Device (IDD), which is a robot arm on either of the Mars Explorer Rovers (MERs). The raw downlinked data files are in comma-separated- value (CSV) format. The present program converts the files into Rover Kinematics State Markup Language (RKSML), which is an Extensible Markup Language (XML) format that facilitates representation of operations of the IDD and enables analysis of the operations by means of the Rover Sequencing Validation Program (RSVP), which is used to build sequences of commanded operations for the MERs. After conversion by means of the present program, the downlinked data can be processed by RSVP, enabling the MER downlink operations team to play back the actual IDD activity represented by the telemetric data against the planned IDD activity. Thus, the present program enhances the diagnosis of anomalies that manifest themselves as differences between actual and planned IDD activities.

  12. DSSTOX MASTER STRUCTURE-INDEX FILE: SDF FILE AND DOCUMENTATION

    EPA Science Inventory

    The DSSTox Master Structure-Index File serves to consolidate, manage, and ensure quality and uniformity of the chemical and substance information spanning all DSSTox Structure Data Files, including those in development but not yet published separately on this website.

  13. 76 FR 348 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-04

    ... Transmission, LLC submits tariff filing per 154.204: AGT Modifications for Bobcat's Link Implementation Filing... Transmission, L.L.C. submits tariff filing per 154.204: Modifications for Bobcat's LINK Implementation Filing... Transmission, LP submits tariff filing per 154.204: TETLP Filing for Bobcat's Link Implementation to...

  14. DSSTOX MASTER STRUCTURE-INDEX FILE: SDF FILE AND ...

    EPA Pesticide Factsheets

    The DSSTox Master Structure-Index File serves to consolidate, manage, and ensure quality and uniformity of the chemical and substance information spanning all DSSTox Structure Data Files, including those in development but not yet published separately on this website. The DSSTox Master Structure-Index File serves to consolidate, manage, and ensure quality and uniformity of the chemical and substance information spanning all DSSTox Structure Data Files, including those in development but not yet published separately on this website.

  15. 76 FR 62092 - Filing Procedures

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-06

    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE... issuing a Handbook on Filing Procedures to replace its Handbook on Electronic Filing Procedures. The revision is necessary to implement a new Commission requirement for electronic filing of most...

  16. A Handbook on File Structuring.

    ERIC Educational Resources Information Center

    Shapiro, Robert M.; And Others

    An initial attempt at presenting a coherent approach to the design and analysis of file structures include a discussion of the relative effeciency of different file implementations as a function of usage statistics. The fundamental differences between item and descriptor-organized files are discussed in terms of input-output requirements.…

  17. Morphological and physiological study of the cardiac NOS/NO system in the Antarctic (Hb-/Mb-) icefish Chaenocephalus aceratus and in the red-blooded Trematomus bernacchii.

    PubMed

    Garofalo, Filippo; Amelio, Daniela; Cerra, Maria C; Tota, Bruno; Sidell, Bruce D; Pellegrino, Daniela

    2009-03-01

    The nitric oxide synthase (NOS)/nitric oxide (NO) system integrates cellular biochemical machinery and energetics. In heart microenvironment, dynamic NO behaviour depends upon the presence of superoxide anions, haemoglobin (Hb), and myoglobin (Mb), being hemoproteins are major players disarming NO bioactivity. The Antarctic icefish, which lack Hb and, in some species, also cardiac Mb, represent a unique model for exploring Hb and Mb impact on NOS/NO function. We report in the (Hb(-)/Mb(-)) icefish Chaenocephalus aceratus the presence of cardiac NOSs activity (NADPH-diaphorase) and endothelial NOS (eNOS)/inducible NOS (iNOS) zonal immuno-localization in the myocardium. eNOS is localized on endocardium and, to a lesser extent, in myocardiocytes, while iNOS is localized exclusively in myocardiocytes. Confronting eNOS and iNOS expression in Trematomus bernacchii (Hb(+)/Mb(+)), C. hamatus (Hb(-)/Mb(+)) and C. aceratus (Hb(-)/Mb(-)) is evident a lower expression in the Mb-less icefish. NO signaling was analyzed using isolated working heart preparations. In T. bernacchii, L-arginine and exogenous (SIN-1) NO donor dose-dependently decreased stroke volume, indicating decreased inotropism. L-arginine-induced inotropism was NOSs-dependent, being abolished by NOSs-inhibitor NG-monomethyl-L-arginine (L-NMMA). A SIN-1-induced negative inotropism was found in presence of SOD. NOS inhibition by L-N5-N-iminoethyl-L-ornithine (L-NIO) and L-NMMA confirmed the NO-mediated negative inotropic influence on cardiac performance. In contrast, in C. aceratus, L-arginine elicited a positive inotropism. SIN-1 induced a negative inotropism, which disappeared in presence of SOD, indicating peroxynitrite involvement. Cardiac performance was unaffected by L-NIO and L-NIL. NO signaling acted via a cGMP-independent mechanism. This high conservation degree of NOS localization pattern and signaling highlights its importance for cardiac biology.

  18. NASA Thesaurus Data File

    NASA Technical Reports Server (NTRS)

    2012-01-01

    The NASA Thesaurus contains the authorized NASA subject terms used to index and retrieve materials in the NASA Aeronautics and Space Database (NA&SD) and NASA Technical Reports Server (NTRS). The scope of this controlled vocabulary includes not only aerospace engineering, but all supporting areas of engineering and physics, the natural space sciences (astronomy, astrophysics, planetary science), Earth sciences, and the biological sciences. The NASA Thesaurus Data File contains all valid terms and hierarchical relationships, USE references, and related terms in machine-readable form. The Data File is available in the following formats: RDF/SKOS, RDF/OWL, ZThes-1.0, and CSV/TXT.

  19. 75 FR 39206 - Marine Mammals; File Nos. 87-1851 and 555-1870

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-08

    ... Ross (Ommatophoca rossii) seals. The permit also authorizes research on California sea lions (Zalophus californianus) to investigate foraging, diving, energetics, food habits, and at-sea distribution. The...

  20. 78 FR 30872 - Marine Mammals; File Nos. 14451, 14353, and 13846

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-23

    ... experiments, and/or suction cup and implant tagging of target whales. The permit includes authorization under the MMPA for the incidental harassment of up to 150 false killer whales during playback experiments in... significantly impact the quality of the human environment and that preparation of an environmental...

  1. 78 FR 2955 - Marine Mammals; File Nos. 14451, 14353, and 13846

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-15

    ... authorization under the MMPA to take 205 false killer whales (Pseudorca crassidens) in Pacific waters off of Hawaii. Insular Hawaiian false killer whales were listed as endangered under the ESA in November 2012; therefore, the permit holder now requires authorization under the ESA to take Insular Hawaiian false...

  2. 77 FR 35657 - Marine Mammals; File Nos. 16163, 16160, and 15569

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-14

    ... Investigator) , 2725 Montlake Blvd. East, Seattle, WA 98112-2097; The Whale Museum (Jenny Atkinson, Responsible Party) , P.O. Box 945, Friday Harbor, WA 98250; and The Center for Whale Research (CWR; Kenneth C... suction- cup tagged. Ultrasound sampling will be directed at killer whales including the Southern...

  3. Accessing files in an Internet: The Jade file system

    NASA Technical Reports Server (NTRS)

    Peterson, Larry L.; Rao, Herman C.

    1991-01-01

    Jade is a new distribution file system that provides a uniform way to name and access files in an internet environment. It makes two important contributions. First, Jade is a logical system that integrates a heterogeneous collection of existing file systems, where heterogeneous means that the underlying file systems support different file access protocols. Jade is designed under the restriction that the underlying file system may not be modified. Second, rather than providing a global name space, Jade permits each user to define a private name space. These private name spaces support two novel features: they allow multiple file systems to be mounted under one directory, and they allow one logical name space to mount other logical name spaces. A prototype of the Jade File System was implemented on Sun Workstations running Unix. It consists of interfaces to the Unix file system, the Sun Network File System, the Andrew File System, and FTP. This paper motivates Jade's design, highlights several aspects of its implementation, and illustrates applications that can take advantage of its features.

  4. Accessing files in an internet - The Jade file system

    NASA Technical Reports Server (NTRS)

    Rao, Herman C.; Peterson, Larry L.

    1993-01-01

    Jade is a new distribution file system that provides a uniform way to name and access files in an internet environment. It makes two important contributions. First, Jade is a logical system that integrates a heterogeneous collection of existing file systems, where heterogeneous means that the underlying file systems support different file access protocols. Jade is designed under the restriction that the underlying file system may not be modified. Second, rather than providing a global name space, Jade permits each user to define a private name space. These private name spaces support two novel features: they allow multiple file systems to be mounted under one directory, and they allow one logical name space to mount other logical name spaces. A prototype of the Jade File System was implemented on Sun Workstations running Unix. It consists of interfaces to the Unix file system, the Sun Network File System, the Andrew File System, and FTP. This paper motivates Jade's design, highlights several aspects of its implementation, and illustrates applications that can take advantage of its features.

  5. 78 FR 17394 - Filing via the Internet; Electronic Tariff Filings; Revisions to Electric Quarterly Report Filing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Filing via the Internet; Electronic Tariff Filings; Revisions to Electric Quarterly Report Filing Process; Notice of Technical Conference Take notice that on April 16, 2013,...

  6. 11 CFR 100.19 - File, filed or filing (2 U.S.C. 434(a)).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... to be filed under 11 CFR parts 101, 102, 104, 105, 107, 108, and 109, and any modifications or...) Except for documents electronically filed under paragraph (c) of this section, a document is timely filed upon delivery to the Federal Election Commission, 999 E Street, NW., Washington, DC 20463; or...

  7. 11 CFR 100.19 - File, filed or filing (2 U.S.C. 434(a)).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... to be filed under 11 CFR parts 101, 102, 104, 105, 107, 108, and 109, and any modifications or...) Except for documents electronically filed under paragraph (c) of this section, a document is timely filed upon delivery to the Federal Election Commission, 999 E Street, NW., Washington, DC 20463; or...

  8. 11 CFR 100.19 - File, filed or filing (2 U.S.C. 434(a)).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... to be filed under 11 CFR parts 101, 102, 104, 105, 107, 108, and 109, and any modifications or...) Except for documents electronically filed under paragraph (c) of this section, a document is timely filed upon delivery to the Federal Election Commission, 999 E Street, NW., Washington, DC 20463; or...

  9. The dual role of iNOS in cancer☆

    PubMed Central

    Vanini, Frederica; Kashfi, Khosrow; Nath, Niharika

    2015-01-01

    Nitric oxide (NO) is one of the 10 smallest molecules found in nature. It is a simple gaseous free radical whose predominant functions is that of a messenger through cGMP. In mammals, NO is synthesized by the enzyme nitric oxide synthase (NOS) of which there are three isoforms. Neuronal (nNOS, NOS1) and endothelial (eNOS, NOS3) are constitutive calcium-dependent forms of the enzyme that regulate neural and vascular function respectively. The third isoform (iNOS, NOS2), is calcium-independent and is inducible. In many tumors, iNOS expression is high, however, the role of iNOS during tumor development is very complex and quite perplexing, with both promoting and inhibiting actions having been described. This review will aim to summarize the dual actions of iNOS-derived NO showing that the microenvironment of the tumor is a contributing factor to these observations and ultimately to cellular outcomes. PMID:26335399

  10. Expression of the nos gene and firefly flashing: a test of the nitric-oxide-mediated flash control model.

    PubMed

    Ohtsuki, Hajime; Yokoyama, Jun; Ohba, Nobuyoshi; Ohmiya, Yoshihiro; Kawata, Masakado

    2014-04-19

    Fireflies (Coleoptera: Lampyridae) emit various types of light that differ among species and populations of the same species. Their lights are assumed to be biological properties that play important ecological and evolutionary roles. Some species in the Lampyridae emit periodic luminescence, the patterns of which are characterized by species-specific intervals. In previous work, it was predicted that the nitric oxide (NO) regulates the oxygen supply required for the bioluminescence reaction of fireflies. Here, the expression of the NO synthase (NOS) mRNA in some fireflies was examined to verify the predictive model of nitric-oxide-mediated flash control in these insects. The expression of the nos gene in the lantern organ was observed not only in nocturnal flashing species but also in diurnal non-flashing species. It was shown that the expression levels of nos were higher in the lantern of Luciola cruciata (Motschulsky) larvae, which that emits continuous light, than in other body parts, although expression in the lantern of the adults, who flash periodically, was not high. Furthermore, there was no significant difference in expression levels among adults of Luciola cruciata characterized by different flashing intervals. The data do not support the model of an NO-mediated flash control mechanism, during which oxygen becomes available for the luciferin-luciferase reaction through NO-mediated inhibition of mitochondrial respiration. It is also indicated that flash patterns do not co-vary with NOS production. However, high nos expression in the larval lantern suggests that NO may play a role in producing continuous light by functioning as a neurotransmitter signal for bioluminescence.

  11. The Global File System

    NASA Technical Reports Server (NTRS)

    Soltis, Steven R.; Ruwart, Thomas M.; OKeefe, Matthew T.

    1996-01-01

    The global file system (GFS) is a prototype design for a distributed file system in which cluster nodes physically share storage devices connected via a network-like fiber channel. Networks and network-attached storage devices have advanced to a level of performance and extensibility so that the previous disadvantages of shared disk architectures are no longer valid. This shared storage architecture attempts to exploit the sophistication of storage device technologies whereas a server architecture diminishes a device's role to that of a simple component. GFS distributes the file system responsibilities across processing nodes, storage across the devices, and file system resources across the entire storage pool. GFS caches data on the storage devices instead of the main memories of the machines. Consistency is established by using a locking mechanism maintained by the storage devices to facilitate atomic read-modify-write operations. The locking mechanism is being prototyped in the Silicon Graphics IRIX operating system and is accessed using standard Unix commands and modules.

  12. Master File Feasibility Study.

    ERIC Educational Resources Information Center

    Broadbent, William A.

    The three purposes for which this study was conducted involved collection and summarization of otherwise unavailable data on student characteristics and aspirations, editing and summarization of reading test data collected over the past six years, and testing of the feasibility and utility of a computerized master file combining student data…

  13. The New Resource File

    ERIC Educational Resources Information Center

    Luck, Donald D.

    2011-01-01

    The development of the resource file is a common experience in teacher preparation programs. The author examines strategies for transforming what has been a project composed of physical resources to one emphasizing digital resources. Methods for finding, tagging, storing and retrieving resources are explored.

  14. Illegal File Sharing 101

    ERIC Educational Resources Information Center

    Wada, Kent

    2008-01-01

    Much of higher education's unease arises from the cost of dealing with illegal file sharing. Illinois State University, for example, calculated a cost of $76 to process a first claim of copyright infringement and $146 for a second. Responses range from simply passing along claims to elaborate programs architected with specific goals in mind.…

  15. "The Bean Files."

    ERIC Educational Resources Information Center

    Haq, Krystyna; Longnecker, Nancy; Hickey, Ruth

    1999-01-01

    Describes classroom use and effectiveness of "The Bean Files," an internet package that uses humorous stories to introduce students to life on a wheat-sheep farm in the Mediterranean climate areas of Australia. The focus of the program is on the role of legume-cereal rotations in the farming system and the science underpinning this…

  16. Icariin improves eNOS/NO pathway to prohibit the atherogenesis of apolipoprotein E-null mice.

    PubMed

    Xiao, Hong-Bo; Sui, Guo-Guang; Lu, Xiang-Yang

    2016-12-22

    Impaired endothelial nitric oxide synthase (eNOS)/nitric oxide (NO) pathway induces atherogenesis. The present study examined whether icariin improves the eNOS/NO pathway to prohibit the atherogenesis of apolipoprotein E-null (ApoE(-/-)) mice. In vitro, primary human umbilical vein endothelial cells (HUVECs) were randomly divided into 7 groups: control; vehicle; icariin 10; lyphosphatidylcholine (LPC) group; LPC + icariin 1; LPC + icariin 3; and LPC + icariin 10. In vivo, 80 mice were separated randomly into 4 groups (n = 20): control, ApoE(-/-), ApoE(-/-) + icariin 10, and ApoE(-/-) + icariin 30. ApoE(-/-) mice had significantly more atherosclerosis in the aortic root together with increased aortic ROS production, body mass, plasma triglyceride (TG) and total cholesterol (TC) concentration, decreased aortic eNOS expression, and plasma NO concentration. LPC (10 μg/mL) treatment induced a big decline in NO level in the conditioned medium and eNOS expression, and an increase in intracellular reactive oxygen species (ROS) production in HUVECs. Icariin treatment decreased atherogenesis, ROS production, body mass, plasma TG concentration, and plasma TC concentration, and increased NO concentration and eNOS expression. These findings suggested icariin could improve eNOS/NO-pathway to prohibit the atherogenesis of apolipoprotein E-null mice by restraining oxidative stress.

  17. iNOS-dependent sweating and eNOS-dependent cutaneous vasodilation are evident in younger adults, but are diminished in older adults exercising in the heat.

    PubMed

    Fujii, Naoto; Meade, Robert D; Alexander, Lacy M; Akbari, Pegah; Foudil-Bey, Imane; Louie, Jeffrey C; Boulay, Pierre; Kenny, Glen P

    2016-02-01

    Nitric oxide synthase (NOS) contributes to sweating and cutaneous vasodilation during exercise in younger adults. We hypothesized that endothelial NOS (eNOS) and neuronal NOS (nNOS) mediate NOS-dependent sweating, whereas eNOS induces NOS-dependent cutaneous vasodilation in younger adults exercising in the heat. Further, aging may upregulate inducible NOS (iNOS), which may attenuate sweating and cutaneous vasodilator responses. We hypothesized that iNOS inhibition would augment sweating and cutaneous vasodilation in exercising older adults. Physically active younger (n = 12, 23 ± 4 yr) and older (n = 12, 60 ± 6 yr) adults performed two 30-min bouts of cycling at a fixed rate of metabolic heat production (400 W) in the heat (35°C). Sweat rate and cutaneous vascular conductance (CVC) were evaluated at four intradermal microdialysis sites with: 1) lactated Ringer (control), 2) nNOS inhibitor (nNOS-I, NPLA), 3) iNOS inhibitor (iNOS-I, 1400W), or 4) eNOS inhibitor (eNOS-I, LNAA). In younger adults during both exercise bouts, all inhibitors decreased sweating relative to control, albeit a lower sweat rate was observed at iNOS-I compared with eNOS-I and nNOS-I sites (all P < 0.05). CVC at the eNOS-I site was lower than control in younger adults throughout the intermittent exercise protocol (all P < 0.05). In older adults, there were no differences between control and iNOS-I sites for sweating and CVC during both exercise bouts (all P > 0.05). We show that iNOS and eNOS are the main contributors to NOS-dependent sweating and cutaneous vasodilation, respectively, in physically active younger adults exercising in the heat, and that iNOS inhibition does not alter sweating or cutaneous vasodilation in exercising physically active older adults.

  18. iNOS-dependent sweating and eNOS-dependent cutaneous vasodilation are evident in younger adults, but are diminished in older adults exercising in the heat

    PubMed Central

    Fujii, Naoto; Meade, Robert D.; Alexander, Lacy M.; Akbari, Pegah; Foudil-bey, Imane; Louie, Jeffrey C.; Boulay, Pierre

    2015-01-01

    Nitric oxide synthase (NOS) contributes to sweating and cutaneous vasodilation during exercise in younger adults. We hypothesized that endothelial NOS (eNOS) and neuronal NOS (nNOS) mediate NOS-dependent sweating, whereas eNOS induces NOS-dependent cutaneous vasodilation in younger adults exercising in the heat. Further, aging may upregulate inducible NOS (iNOS), which may attenuate sweating and cutaneous vasodilator responses. We hypothesized that iNOS inhibition would augment sweating and cutaneous vasodilation in exercising older adults. Physically active younger (n = 12, 23 ± 4 yr) and older (n = 12, 60 ± 6 yr) adults performed two 30-min bouts of cycling at a fixed rate of metabolic heat production (400 W) in the heat (35°C). Sweat rate and cutaneous vascular conductance (CVC) were evaluated at four intradermal microdialysis sites with: 1) lactated Ringer (control), 2) nNOS inhibitor (nNOS-I, NPLA), 3) iNOS inhibitor (iNOS-I, 1400W), or 4) eNOS inhibitor (eNOS-I, LNAA). In younger adults during both exercise bouts, all inhibitors decreased sweating relative to control, albeit a lower sweat rate was observed at iNOS-I compared with eNOS-I and nNOS-I sites (all P < 0.05). CVC at the eNOS-I site was lower than control in younger adults throughout the intermittent exercise protocol (all P < 0.05). In older adults, there were no differences between control and iNOS-I sites for sweating and CVC during both exercise bouts (all P > 0.05). We show that iNOS and eNOS are the main contributors to NOS-dependent sweating and cutaneous vasodilation, respectively, in physically active younger adults exercising in the heat, and that iNOS inhibition does not alter sweating or cutaneous vasodilation in exercising physically active older adults. PMID:26586908

  19. eNOS-Dependent Antisenscence Effect of a Calcium Channel Blocker in Human Endothelial Cells

    PubMed Central

    Hayashi, Toshio; Yamaguchi, Tomoe; Sakakibara, Yasufumi; Taguchi, Kumiko; Maeda, Morihiko; Kuzuya, Masafumi; Hattori, Yuichi

    2014-01-01

    Senescence of vascular endothelial cells is an important contributor to the pathogenesis of age-associated vascular disorders such as atherosclerosis. We investigated the effects of antihypertensive agents on high glucose-induced cellular senescence in human umbilical venous endothelial cells (HUVECs). Exposure of HUVECs to high glucose (22 mM) for 3 days increased senescence-associated- β-galactosidase (SA-β-gal) activity, a senescence marker, and decreased telomerase activity, a replicative senescence marker. The calcium channel blocker nifedipine, but not the β1-adrenergic blocking agent atenolol or the angiotensin-converting enzyme inhibitor perindopril, reduced SA-β-gal positive cells and prevented a decrease in telomerase activity in a high-glucose environment. This beneficial effect of nifedipine was associated with reduced reactive oxygen species (ROS) and increased endothelial nitric oxide synthase (eNOS) activity. Thus, nifedipine prevented high glucose-induced ROS generation and increased basal eNOS phosphorylation level at Ser-1177. Treatment with NG-nitro-L-arginine (L-NAME) and transfection of small interfering RNA (siRNA) targeting eNOS eliminated the anti-senscence effect of nifedipine. These results demonstrate that nifedipine can prevent endothelial cell senescence in an eNOS-dependent manner. The anti-senescence action of nifedipine may represent a novel mechanism by which it protects against atherosclerosis. PMID:24520379

  20. San Francisco Bay Area Endangered Species Litigation: The Complaint

    EPA Pesticide Factsheets

    The Center for Biological Diversity filed a lawsuit in the United States District Court for the Northern District of California alleging that EPA failed to comply with the ESA related to 47 pesticides and 11 endangered or threatened species.

  1. 76 FR 27660 - Endangered Species; Marine Mammals; Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-12

    ... endangered species, we found that (1) The application was filed in good faith, (2) The granted permit would... Zoological 76 FR 12990; March 9, April 21, 2011. Society dba 2011. Brookfield Zoo. 24269A Chelonian...

  2. 77 FR 58406 - Endangered Species; Marine Mammals; Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-20

    ... endangered species, we found that (1) The application was filed in good faith, (2) The granted permit would... Zoo and 77 FR 46514; August 3, August 27, 2012. Garden. 2012. Marine Mammals Receipt of...

  3. 76 FR 60863 - Endangered Species; Marine Mammals; Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-30

    ... endangered species, we found that (1) The application was filed in good faith, (2) The granted permit would... September 22, 2011. Society dba Gladys 17, 2011. Porter Zoo. Marine Mammals 48293A Red Rock Films 76...

  4. 77 FR 38653 - Endangered Species; Marine Mammals; Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-28

    ... endangered species, we found that (1) the application was filed in good faith, (2) the granted permit would.... 58210A Point Defiance Zoo & 77 FR 9687; February May 4, 2012. Aquarium. 17, 2012. 65782A, 65783A,...

  5. 77 FR 19313 - Endangered Species; Marine Mammals; Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-30

    ... endangered species, we found that (1) The application was filed in good faith, (2) The granted permit would... Richmond 77 FR 3493: March 15, 2012. Zoo. January 24, 2012. 694126 National 76 FR 80384; March 15,...

  6. 76 FR 11762 - Marine Mammals; File No. 15330; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-03

    ...'' from the Features box on the Applications and Permits for Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No. 15530 from the list of available applications. These... East-West Highway, Room 13705, Silver Spring, MD 20910; phone (301)713-2289; fax...

  7. 75 FR 20565 - Marine Mammals; File No. 14636

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-20

    ...'' from the Features box on the Applications and Permits for Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No. 14636 from the list of available applications. These..., Silver Spring, MD 20910; phone (301) 713-2289; fax (301) 713-0376; and Southwest Region, NMFS, 501...

  8. 76 FR 28421 - Marine Mammals; File No. 15646

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-17

    ...'' from the Features box on the Applications and Permits for Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No. 15646 from the list of available applications. These..., Silver Spring, MD 20910; phone (301) 713-2289; fax (301) 713-0376; Southwest Region, NMFS, 501 West...

  9. 76 FR 13603 - Marine Mammals; File No. 15748

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-14

    ... Public Comment'' from the Features box on the Applications and Permits for Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No. 15748 from the list of available...-West Highway, Room 13705, Silver Spring, MD 20910; phone (301) 713-2289; fax (301) 713-0376; and...

  10. Relationships between polymorphisms in NOS3 and MPO genes, cigarette smoking and risk of post-menopausal breast cancer.

    PubMed

    Yang, Jun; Ambrosone, Christine B; Hong, Chi-Chen; Ahn, Jiyoung; Rodriguez, Carmen; Thun, Michael J; Calle, Eugenia E

    2007-06-01

    NOS3 and MPO genes encode endothelial nitric oxide synthase and myeloperoxidase (MPO), respectively, which generate nitric oxide and reactive oxygen species. Because cigarette smoking generates reactive species, we hypothesized that NOS3 and MPO polymorphisms could influence susceptibility to breast cancer, particularly among smokers. We examined the associations between NOS3 Glu298Asp and MPO G-463A polymorphisms and breast cancer risk by cigarette smoking among post-menopausal women in the American Cancer Society's Cancer Prevention Study II Nutrition Cohort. Included in this analysis were 502 women who provided blood samples and were diagnosed with breast cancer between 1992 and 2001 and 505 cancer-free controls who were matched to the cases by age, race/ethnicity and date of blood donation. Genotyping for NOS3 and MPO was performed using TaqMan, and unconditional logistic regression was used to compute odds ratios (ORs) and 95% confidence intervals (CIs). No statistically significant relationships were found between NOS3 and MPO genotypes and breast cancer risk. When considering smoking, variant NOS3 genotypes (GT and TT) were significantly associated with reduced breast cancer risk among never smokers (OR = 0.67, 95% CI = 0.45-0.99), but were associated with higher risk among ever smokers (OR = 1.59, 95% CI = 1.05-2.41) and 2-fold increase in risk for those who smoked >10 cigarettes per day (OR = 2.19, 95% CI = 1.21-3.97). NOS3 genotypes appeared to be associated with risk of post-menopausal breast cancer among smokers, supporting the hypothesis that subgroups of women based upon genetic profiles may be at higher risk of breast cancer when exposed to tobacco smoke.

  11. Diminished Neurogenic Femoral Artery Vasoconstrictor Response in a Zucker Obese Rat Model: Differential Regulation of NOS and COX Derivatives

    PubMed Central

    Martínez, Ana Cristina; Hernández, Medardo; Novella, Susana; Martínez, María Pilar; Pagán, Rosa María; Hermenegildo, Carlos; García-Sacristán, Albino; Prieto, Dolores; Benedito, Sara

    2014-01-01

    Objective Peripheral arterial disease is one of the macrovascular complications of type 2 diabetes mellitus. This study addresses femoral artery regulation in a prediabetic model of obese Zucker rats (OZR) by examining cross-talk between endothelial and neural factors. Methods and Results Arterial preparations from lean (LZR) and OZR were subjected to electrical field stimulation (EFS) on basal tone. Nitric oxide synthase (NOS) and cyclooxygenase (COX) isoform expression patterns were determined by immunohistochemical labelling and Western blotting. Results indicate significantly reduced noradrenergic contractions in preparations from OZR compared with those of LZR. Functional inhibition of endothelial NOS (eNOS) indicated a predominant role of this isoform in LZR and its modified activity in OZR. Neural (nNOS) and inducible NOS (iNOS) were activated and their expression was higher in femoral arteries from OZR. Neurotransmission modulated by large-conductance Ca2+-activated (BKCa) or voltage-dependent (KV) K+ channels did not seem compromised in the obese animals. Endothelial COX-1 and COX-2 were expressed in LZR and an additional adventitial location of COX-2 was also observed in OZR, explaining the higher COX-2 protein levels detected in this group. Prostanoids derived from both isoforms helped maintain vasoconstriction in LZR while in OZR only COX-2 was active. Superoxide anion inhibition reduced contractions in endothelium-intact arteries from OZR. Conclusions Endothelial dysfunction led to reduced neurogenic vasoconstriction in femoral arteries from OZR. In a setting of obesity, NO-dependent nNOS and iNOS dilation activity could be an alternative mechanism to offset COX-2- and reactive oxygen species-mediated vasoconstriction, along with impaired endothelial NO relaxation. PMID:25216050

  12. 75 FR 50757 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-17

    ..., Inc. submits tariff filing per 154.204: DTI--Non-Conforming Service Agreements to be effective 8/30... Line Company, LLC submits tariff filing per 154.403: S-2 Tracker Filing to be effective 8/1/2010. Filed.... Description: Transwestern Pipeline Company, LLC submits its baseline tariff filing of its FERC Gas...

  13. Break up a File with EDLIN.

    ERIC Educational Resources Information Center

    Koga, James S.

    Online searchers who download large amounts of data into a single ASCII file often have difficulty fitting that large file into their MS-DOS word processors for post-processing. This paper gives step-by-step instructions for using EDLIN, a text editor for DOS files, to break up a large downloaded file into smaller files. (1 reference) (Author/EW)

  14. 48 CFR 4.802 - Contract files.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract files. 4.802... MATTERS Government Contract Files 4.802 Contract files. (a) A contract file should generally consist of— (1) The contracting office contract file, that documents the basis for the acquisition and the...

  15. 12 CFR 5.4 - Filing required.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... CORPORATE ACTIVITIES Rules of General Applicability § 5.4 Filing required. (a) Filing. A depository institution shall file an application or notice with the OCC to engage in corporate activities and... advise an applicant through a pre-filing communication to send the filing or submission directly to...

  16. 43 CFR 4.1362 - Where to file; when to file.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Where to file; when to file. 4.1362... file; when to file. (a) The request for review shall be filed with the Hearings Division, Office of... bear the expense for this service. (b) Failure to file a request for review within the time...

  17. A Scallop Nitric Oxide Synthase (NOS) with Structure Similar to Neuronal NOS and Its Involvement in the Immune Defense

    PubMed Central

    Jiang, Qiufen; Zhou, Zhi; Wang, Leilei; Wang, Lingling; Yue, Feng; Wang, Jingjing; Song, Linsheng

    2013-01-01

    Background Nitric oxide synthase (NOS) is responsible for synthesizing nitric oxide (NO) from L-arginine, and involved in multiple physiological functions. However, its immunological role in mollusc was seldom reported. Methodology In the present study, an NOS (CfNOS) gene was identified from the scallop Chlamys farreri encoding a polypeptide of 1486 amino acids. Its amino acid sequence shared 50.0~54.7, 40.7~47.0 and 42.5~44.5% similarities with vertebrate neuronal (n), endothelial (e) and inducible (i) NOSs, respectively. CfNOS contained PDZ, oxygenase and reductase domains, which resembled those in nNOS. The CfNOS mRNA transcripts expressed in all embryos and larvae after the 2-cell embryo stage, and were detectable in all tested tissues with the highest level in the gonad, and with the immune tissues hepatopancreas and haemocytes included. Moreover, the immunoreactive area of CfNOS distributed over the haemocyte cytoplasm and cell membrane. After LPS, β-glucan and PGN stimulation, the expression level of CfNOS mRNA in haemocytes increased significantly at 3 h (4.0-, 4.8- and 2.7-fold, respectively, P < 0.01), and reached the peak at 12 h (15.3- and 27.6-fold for LPS and β-glucan respectively, P < 0.01) and 24 h (17.3-fold for PGN, P < 0.01). In addition, TNF-α also induced the expression of CfNOS, which started to increase at 1 h (5.2-fold, P < 0.05) and peaked at 6 h (19.9-fold, P < 0.01). The catalytic activity of the native CfNOS protein was 30.3 ± 0.3 U mgprot-1, and it decreased significantly after the addition of the selective inhibitors of nNOS and iNOS (26.9 ± 0.4 and 29.3 ± 0.1 U mgprot-1, respectively, P < 0.01). Conclusions These results suggested that CfNOS, with identical structure with nNOS and similar enzymatic characteristics to nNOS and iNOS, played the immunological role of iNOS to be involved in the scallop immune defense against PAMPs and TNF-α. PMID:23922688

  18. Reactive oxygen species in iridium-based OER catalysts† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc01860b Click here for additional data file.

    PubMed Central

    Pfeifer, Verena; Wrabetz, Sabine; Massué, Cyriac; Velasco Vélez, Juan J.; Arrigo, Rosa; Scherzer, Michael; Piccinin, Simone; Hävecker, Michael; Knop-Gericke, Axel; Schlögl, Robert

    2016-01-01

    Tremendous effort has been devoted towards elucidating the fundamental reasons for the higher activity of hydrated amorphous IrIII/IV oxyhydroxides (IrOx) in the oxygen evolution reaction (OER) in comparison with their crystalline counterpart, rutile-type IrO2, by focusing on the metal oxidation state. Here we demonstrate that, through an analogy to photosystem II, the nature of this reactive species is not solely a property of the metal but is intimately tied to the electronic structure of oxygen. We use a combination of synchrotron-based X-ray photoemission and absorption spectroscopies, ab initio calculations, and microcalorimetry to show that holes in the O 2p states in amorphous IrOx give rise to a weakly bound oxygen that is extremely susceptible to nucleophilic attack, reacting stoichiometrically with CO already at room temperature. As such, we expect this species to play the critical role of the electrophilic oxygen involved in O–O bond formation in the electrocatalytic OER on IrOx. We propose that the dynamic nature of the Ir framework in amorphous IrOx imparts the flexibility in Ir oxidation state required for the formation of this active electrophilic oxygen. PMID:28042464

  19. Large File System Backup: NERSC Global File System Experience

    SciTech Connect

    Mokhtarani, Akbar; Andrews, Matthew; Hick, Jason; Kramer, William

    2008-10-23

    NERSC's Global File system (NGF), accessible from all compute systems at NERSC, holds files and data from many scientific projects. A full backup of this file system to our High Performance Storage System (HPSS) is performed periodically. Disk storage usage by projects at NERSC has grown seven fold over a two year period, from ~;;20TB in June 2006 to ~;;140 TB in June 2008. The latest full backup took about 13 days and more than 200 T10k tape cartridges (.5 TB capacity). Petabyte file systems are becoming a reality in the next few years and the existing utilities are already strained in handling backup tasks.

  20. The Galley Parallel File System

    NASA Technical Reports Server (NTRS)

    Nieuwejaar, Nils; Kotz, David

    1996-01-01

    As the I/O needs of parallel scientific applications increase, file systems for multiprocessors are being designed to provide applications with parallel access to multiple disks. Many parallel file systems present applications with a conventional Unix-like interface that allows the application to access multiple disks transparently. The interface conceals the parallelism within the file system, which increases the ease of programmability, but makes it difficult or impossible for sophisticated programmers and libraries to use knowledge about their I/O needs to exploit that parallelism. Furthermore, most current parallel file systems are optimized for a different workload than they are being asked to support. We introduce Galley, a new parallel file system that is intended to efficiently support realistic parallel workloads. We discuss Galley's file structure and application interface, as well as an application that has been implemented using that interface.

  1. The Galley Parallel File System

    NASA Technical Reports Server (NTRS)

    Nieuwejaar, Nils; Kotz, David

    1996-01-01

    Most current multiprocessor file systems are designed to use multiple disks in parallel, using the high aggregate bandwidth to meet the growing I/0 requirements of parallel scientific applications. Many multiprocessor file systems provide applications with a conventional Unix-like interface, allowing the application to access multiple disks transparently. This interface conceals the parallelism within the file system, increasing the ease of programmability, but making it difficult or impossible for sophisticated programmers and libraries to use knowledge about their I/O needs to exploit that parallelism. In addition to providing an insufficient interface, most current multiprocessor file systems are optimized for a different workload than they are being asked to support. We introduce Galley, a new parallel file system that is intended to efficiently support realistic scientific multiprocessor workloads. We discuss Galley's file structure and application interface, as well as the performance advantages offered by that interface.

  2. Secure Distributed File Systems

    DTIC Science & Technology

    1994-09-01

    practicality and applicability of one such system, Trusted Ficus File System ( TRUFFLES ), in the DoD infrastructure. Integrated into this research are...discussions of Privacy Enhanced Mail (PEM), which is currently an integral part of the TRUFFLES implementation. This thesis concludes with a discussion of the...actual installation of a PEM reference implementation, and future requirements for the TRUFFLES installation at the Naval Postgraduate School. 14

  3. MERRA-2: File Specification

    NASA Technical Reports Server (NTRS)

    Bosilovich, M. G.; Lucchesi, R.; Suarez, M.

    2015-01-01

    The second Modern-Era Retrospective analysis for Research and Applications (MERRA-2) is a NASA atmospheric reanalysis that begins in 1980. It replaces the original MERRA reanalysis (Rienecker et al., 2011) using an upgraded version of the Goddard Earth Observing System Model, Version 5 (GEOS-5) data assimilation system. The file collections for MERRA-2 are described in detail in this document, including some important changes from those of the MERRA dataset (Lucchesi, 2012).

  4. Regulation of eNOS-derived superoxide by endogenous methylarginines.

    PubMed

    Druhan, Lawrence J; Forbes, Scott P; Pope, Arthur J; Chen, Chun-An; Zweier, Jay L; Cardounel, Arturo J

    2008-07-08

    The endogenous methylarginines, asymmetric dimethylarginine (ADMA) and N (G)-monomethyl- l-arginine (L-NMMA) regulate nitric oxide (NO) production from endothelial NO synthase (eNOS). Under conditions of tetrahydrobiopterin (BH 4) depletion eNOS also generates (*)O 2 (-); however, the effects of methylarginines on eNOS-derived (*)O 2 (-) generation are poorly understood. Therefore, using electron paramagnetic resonance spin trapping techniques we measured the dose-dependent effects of ADMA and L-NMMA on (*)O 2 (-) production from eNOS under conditions of BH 4 depletion. In the absence of BH 4, ADMA dose-dependently increased NOS-derived (*)O 2 (-) generation, with a maximal increase of 151% at 100 microM ADMA. L-NMMA also dose-dependently increased NOS-derived (*)O 2 (-), but to a lesser extent, demonstrating a 102% increase at 100 microM L-NMMA. Moreover, the native substrate l-arginine also increased eNOS-derived (*)O 2 (-), exhibiting a similar degree of enhancement as that observed with ADMA. Measurements of NADPH consumption from eNOS demonstrated that binding of either l-arginine or methylarginines increased the rate of NADPH oxidation. Spectrophotometric studies suggest, just as for l-arginine and L-NMMA, the binding of ADMA shifts the eNOS heme to the high-spin state, indicative of a more positive heme redox potential, enabling enhanced electron transfer from the reductase to the oxygenase site. These results demonstrate that the methylarginines can profoundly shift the balance of NO and (*)O 2 (-) generation from eNOS. These observations have important implications with regard to the therapeutic use of l-arginine and the methylarginine-NOS inhibitors in the treatment of disease.

  5. 18 CFR 34.7 - Filing requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... SECURITIES OR THE ASSUMPTION OF LIABILITIES § 34.7 Filing requirements. Applications must be filed with the Secretary of the Commission in accordance with filing procedures posted on the Commission's Web site at...

  6. 18 CFR 34.7 - Filing requirements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... SECURITIES OR THE ASSUMPTION OF LIABILITIES § 34.7 Filing requirements. Applications must be filed with the Secretary of the Commission in accordance with filing procedures posted on the Commission's Web site at...

  7. 76 FR 30333 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-25

    .... Applicants: ETC Tiger Pipeline, LLC. Description: ETC Tiger Pipeline, LLC submits tariff filing per 154.403(d)(2): ETC Tiger 2011--04--28 Out of Cycle Fuel Filing to be effective 6/1/2011. Filed Date:...

  8. 76 FR 48836 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-09

    ... Line Company, LLC submits tariff filing per 154.403: S-2 Tracker Filing to be effective 8/1/2011. Filed...-000. Applicants: Cimarron River Pipeline, LLC. Description: 2011 Annual Report of Cash Out Activity...

  9. 75 FR 67357 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-02

    .... Applicants: ETC Tiger Pipeline, LLC. Description: ETC Tiger Pipeline, LLC submits tariff filing per 154.203: Tiger FTSA Non-Conforming Agreement Filing to be effective 12/ 1/2010. Filed Date: 10/25/2010....

  10. Cytoscape file of chemical networks

    EPA Pesticide Factsheets

    The maximum connectivity scores of pairwise chemical conditions summarized from Cmap results in a file with Cytoscape format (http://www.cytoscape.org/). The figures in the publication were generated from this file. The Cytoscape file is formed from importing the eight text file therein.This dataset is associated with the following publication:Wang , R., A. Biales , N. Garcia-Reyero, E. Perkins, D. Villeneuve, G. Ankley, and D. Bencic. Fish Connectivity Mapping: Linking Chemical Stressors by Their MOA-Driven Transcriptomic Profiles. BMC Genomics. BioMed Central Ltd, London, UK, 17(84): 1-20, (2016).

  11. The Internet Toolkit: File Compression and Archive Utilities.

    ERIC Educational Resources Information Center

    Delfino, Erik

    1993-01-01

    Describes utility programs available for posttransfer processing files that have been downloaded from the Internet. Highlights include file compression; viewing graphics files; converting binary files to ASCII files; and how to find utility programs. (LRW)

  12. 15 CFR Supplement Nos. 2-3 to Part... - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Nos. Supplement Nos. 2-3 to Part 716 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS INITIAL AND...

  13. 15 CFR Supplement Nos. 2-3 to Part... - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Nos. Supplement Nos. 2-3 to Part 716 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS INITIAL AND...

  14. 15 CFR Supplement Nos. 2-3 to Part... - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Nos. Supplement Nos. 2-3 to Part 716 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS INITIAL AND...

  15. 15 CFR Supplement Nos. 2-3 to Part... - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false Nos. Supplement Nos. 2-3 to Part 716 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS INITIAL AND...

  16. 15 CFR Supplement Nos. 2-3 to Part... - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false Nos. Supplement Nos. 2-3 to Part 716 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS INITIAL AND...

  17. Face and Emotion Recognition in MCDD versus PDD-NOS

    ERIC Educational Resources Information Center

    Herba, Catherine M.; de Bruin, Esther; Althaus, Monika; Verheij, Fop; Ferdinand, Robert F.

    2008-01-01

    Previous studies indicate that Multiple Complex Developmental Disorder (MCDD) children differ from PDD-NOS and autistic children on a symptom level and on psychophysiological functioning. Children with MCDD (n = 21) and PDD-NOS (n = 62) were compared on two facets of social-cognitive functioning: identification of neutral faces and facial…

  18. Storing files in a parallel computing system using list-based index to identify replica files

    DOEpatents

    Faibish, Sorin; Bent, John M.; Tzelnic, Percy; Zhang, Zhenhua; Grider, Gary

    2015-07-21

    Improved techniques are provided for storing files in a parallel computing system using a list-based index to identify file replicas. A file and at least one replica of the file are stored in one or more storage nodes of the parallel computing system. An index for the file comprises at least one list comprising a pointer to a storage location of the file and a storage location of the at least one replica of the file. The file comprises one or more of a complete file and one or more sub-files. The index may also comprise a checksum value for one or more of the file and the replica(s) of the file. The checksum value can be evaluated to validate the file and/or the file replica(s). A query can be processed using the list.

  19. 76 FR 53676 - Combined Notice of Filings; Filings Instituting Proceedings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-29

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings; Filings Instituting Proceedings Take... Northern's FERC Gas Tariff to resolve a prior period imbalance with the high Monthly Index Price...

  20. Converting Inhouse Subject Card Files to Electronic Keyword Files.

    ERIC Educational Resources Information Center

    Culmer, Carita M.

    The library at Phoenix College developed the Controversial Issues Files (CIF), a "home made" card file containing references pertinent to specific ongoing assignments. Although the CIF had proven itself to be an excellent resource tool for beginning researchers, it was cumbersome to maintain in the card format, and was limited to very…

  1. IFN-γ regulates xanthine oxidase-mediated iNOS-independent oxidative stress in maneb- and paraquat-treated rat polymorphonuclear leukocytes.

    PubMed

    Singh, Deepali; Kumar, Vinod; Singh, Chetna

    2017-03-01

    Maneb (MB) and paraquat (PQ) provoke oxidative stress-mediated cell damage. Role of xanthine oxidase (XO) in oxidative stress and its association with nitric oxide (NO)/NO synthase (NOS) have been widely reported. While inducible NOS (iNOS) is implicated in MB+PQ-induced toxicity in rat polymorphonuclear leukocytes (PMNs), role of XO and its alliance with iNOS have not yet been established. The study investigated the role of XO in MB+PQ-induced oxidative stress in rat PMNs and its regulation by iNOS and inflammatory cytokines. MB+PQ-augmented reactive oxygen species (ROS), superoxide, nitro-tyrosine, lipid peroxidation (LPO), and nitrite levels along with the catalytic activity of iNOS, superoxide dismutase (SOD), and XO. XO inhibitor, allopurinol (AP), alleviated MB+PQ-induced changes except nitrite content and iNOS activity. Conversely, an iNOS inhibitor, aminoguanidine, mitigated MB+PQ-induced LPO, nitrite, iNOS, and nitro-tyrosine levels; however, no change was observed in ROS, SOD, and XO. Nuclear factor-κB inhibitor, pyrrolidine dithiocarbamate (PDTC), tumor necrosis factor-alpha (TNF-α) inhibitor, pentoxyfylline, and an anti-inflammatory agent, dexamethasone, attenuated MB+PQ-induced increase in XO, superoxide, and ROS with parallel reduction in the expression of interferon-gamma (IFN-γ), TNF-α, and interleukin-1β (IL-1β) in rat PMNs. Exogenous IFN-γ, TNF-α, and IL-1β enhanced superoxide, ROS, and XO in the PMNs of control and MB+PQ-treated rats; however, IFN- γ was found to be the most potent inducer. Moreover, AP ameliorated cytokine-induced free radical generation and restored XO activity towards normalcy. The results thus demonstrate that XO mediates oxidative stress in MB+PQ-treated rat PMNs via iNOS-independent but cytokine (predominantly IFN-γ)-dependent mechanism.

  2. DISTRIBUTION OF NOS ISOFORMS IN A PORCINE ENDOTOXIN SHOCK MODEL

    PubMed Central

    Doursout, Marie-Francoise; Oguchi, Takeshi; Fischer, Uwe M.; Liang, YangYan; Chelly, Brice; Hartley, Craig J.; Chelly, Jacques E.

    2012-01-01

    Sepsis is a major cause of morbidity and mortality. NO, an endogenous vasodilator, has been associated with the hypotension, catecholamine hyporesponsiveness, and myocardial depression of septic shock. Although iNOS is thought to be responsible for the hypotension and loss of vascular tone occurring several hours after endotoxin administration, little is known on the effects of constitutive eNOS on LPS-induced organ dysfunction. This study assessed the distribution of eNOS and iNOS in various vascular beds in conscious pigs challenged with LPS. Cardiac and regional hemodynamic parameters were recorded over 8 h in the presence and absence of aminoguanidine, a rather selective inhibitor of iNOS activity, and N-methyl-L-arginine, a nonspecific NOS inhibitor. Our data show that LPS-induced cardiac depression was associated with coronary, renal, and mesenteric vasoconstrictions and a hepatic vasodilatation. LPS also induced increases in eNOS in the heart and lungs, whereas iNOS was mostly detected in the liver. Nitrotyrosine formation was mainly detected in the lungs, with traces in the kidney, liver, and gut. Accordingly, our results suggest that the early decrease in blood pressure and cardiac depression are likely due to activated eNOS, whereas both isoforms are involved in the hepatic vasodilation. In contrast, carotid, coronary, mesenteric, and renal vasoconstrictions were significant at 5 and/or 6 h after LPS infusion, suggesting that NO is not the primary mediator, facilitating and/or unmasking the release of vasoconstrictor mediators. Consequently, developing newer tissue- or isoform-specific NOS inhibitors can lead to novel therapeutic agents in septic shock. PMID:17909454

  3. Vascular nitric oxide: Beyond eNOS.

    PubMed

    Zhao, Yingzi; Vanhoutte, Paul M; Leung, Susan W S

    2015-10-01

    As the first discovered gaseous signaling molecule, nitric oxide (NO) affects a number of cellular processes, including those involving vascular cells. This brief review summarizes the contribution of NO to the regulation of vascular tone and its sources in the blood vessel wall. NO regulates the degree of contraction of vascular smooth muscle cells mainly by stimulating soluble guanylyl cyclase (sGC) to produce cyclic guanosine monophosphate (cGMP), although cGMP-independent signaling [S-nitrosylation of target proteins, activation of sarco/endoplasmic reticulum calcium ATPase (SERCA) or production of cyclic inosine monophosphate (cIMP)] also can be involved. In the blood vessel wall, NO is produced mainly from l-arginine by the enzyme endothelial nitric oxide synthase (eNOS) but it can also be released non-enzymatically from S-nitrosothiols or from nitrate/nitrite. Dysfunction in the production and/or the bioavailability of NO characterizes endothelial dysfunction, which is associated with cardiovascular diseases such as hypertension and atherosclerosis.

  4. Endothelial function does not improve with high-intensity continuous exercise training in SHR: implications of eNOS uncoupling.

    PubMed

    Battault, Sylvain; Singh, François; Gayrard, Sandrine; Zoll, Joffrey; Reboul, Cyril; Meyer, Grégory

    2016-02-01

    Exercise training is a well-recognized way to improve vascular endothelial function by increasing nitric oxide (NO) bioavailability. However, in hypertensive subjects, unlike low- and moderate-intensity exercise training, the beneficial effects of continuous high-intensity exercise on endothelial function are not clear, and the underlying mechanisms remain unknown. The aim of this study was to investigate the impact of high-intensity exercise on vascular function, especially on the NO pathway, in spontaneous hypertensive rats (SHR). These effects were studied on WKY, sedentary SHR and SHR that exercised at moderate (SHR-MOD) and high intensity (SHR-HI) on a treadmill (1 h per day; 5 days per week for 6 weeks at 55% and 80% of their maximal aerobic velocity, respectively). Endothelial function and specific NO contributions to acetylcholine-mediated relaxation were evaluated by measuring the aortic ring isometric forces. Endothelial nitric oxide synthase (eNOS) expression and phosphorylation (ser1177) were evaluated by western blotting. The total aortic and eNOS-dependent reactive oxygen species (ROS) production was assessed using electron paramagnetic resonance in aortic tissue. Although the aortas of SHR-HI had increased eNOS levels without alteration of eNOS phosphorylation, high-intensity exercise had no beneficial effect on endothelium-dependent vasorelaxation, unlike moderate exercise. This result was associated with increased eNOS-dependent ROS production in the aortas of SHR-HI. Notably, the use of the recoupling agent BH4 or a thiol-reducing agent blunted eNOS-dependent ROS production in the aortas of SHR-HI. In conclusion, the lack of a positive effect of high-intensity exercise on endothelial function in SHR was mainly explained by redox-dependent eNOS uncoupling, resulting in a switch from NO to O2(-) generation.

  5. Advancing the Perceptions of the Nature of Science (NOS): Integrating Teaching the NOS in a Science Content Course

    ERIC Educational Resources Information Center

    Aflalo, Ester

    2014-01-01

    Background: Understanding the nature of science (NOS) has been a key objective in teaching sciences for many years. Despite the importance of this goal it is, until this day, a complex challenge that we are far from achieving. Purpose: The study was conducted in order to further the understanding of the NOS amongst preservice teachers. It explores…

  6. Species concepts and species delimitation.

    PubMed

    De Queiroz, Kevin

    2007-12-01

    The issue of species delimitation has long been confused with that of species conceptualization, leading to a half century of controversy concerning both the definition of the species category and methods for inferring the boundaries and numbers of species. Alternative species concepts agree in treating existence as a separately evolving metapopulation lineage as the primary defining property of the species category, but they disagree in adopting different properties acquired by lineages during the course of divergence (e.g., intrinsic reproductive isolation, diagnosability, monophyly) as secondary defining properties (secondary species criteria). A unified species concept can be achieved by treating existence as a separately evolving metapopulation lineage as the only necessary property of species and the former secondary species criteria as different lines of evidence (operational criteria) relevant to assessing lineage separation. This unified concept of species has several consequences for species delimitation, including the following: First, the issues of species conceptualization and species delimitation are clearly separated; the former secondary species criteria are no longer considered relevant to species conceptualization but only to species delimitation. Second, all of the properties formerly treated as secondary species criteria are relevant to species delimitation to the extent that they provide evidence of lineage separation. Third, the presence of any one of the properties (if appropriately interpreted) is evidence for the existence of a species, though more properties and thus more lines of evidence are associated with a higher degree of corroboration. Fourth, and perhaps most significantly, a unified species concept shifts emphasis away from the traditional species criteria, encouraging biologists to develop new methods of species delimitation that are not tied to those properties.

  7. Endothelial NOS-dependent activation of c-Jun NH(2)- terminal kinase by oxidized low-density lipoprotein

    NASA Technical Reports Server (NTRS)

    Go, Y. M.; Levonen, A. L.; Moellering, D.; Ramachandran, A.; Patel, R. P.; Jo, H.; Darley-Usmar, V. M.

    2001-01-01

    Oxidized low-density lipoprotein (oxLDL) is known to activate a number of signal transduction pathways in endothelial cells. Among these are the c-Jun NH(2)-terminal kinase (JNK), also known as stress-activated protein kinase, and extracellular signal-regulated kinase (ERK). These mitogen-activated protein kinases (MAP kinase) determine cell survival in response to environmental stress. Interestingly, JNK signaling involves redox-sensitive mechanisms and is activated by reactive oxygen and nitrogen species derived from both NADPH oxidases, nitric oxide synthases (NOS), peroxides, and oxidized low-density lipoprotein (oxLDL). The role of endothelial NOS (eNOS) in the activation of JNK in response to oxLDL has not been examined. Herein, we show that on exposure of endothelial cells to oxLDL, both ERK and JNK are activated through independent signal transduction pathways. A key role of eNOS activation through a phosphatidylinositol-3-kinase-dependent mechanism leading to phosphorylation of eNOS is demonstrated for oxLDL-dependent activation of JNK. Moreover, we show that activation of ERK by oxLDL is critical in protection against the cytotoxicity of oxLDL.

  8. The flavinyl transferase ApbE of Pseudomonas stutzeri matures the NosR protein required for nitrous oxide reduction.

    PubMed

    Zhang, Lin; Trncik, Christian; Andrade, Susana L A; Einsle, Oliver

    2017-02-01

    The copper-containing enzyme nitrous oxide reductase (N2OR) catalyzes the transformation of nitrous oxide (N2O) to dinitrogen (N2) in microbial denitrification. Several accessory factors are essential for assembling the two copper sites CuA and CuZ, and for maintaining the activity. In particular, the deletion of either the transmembrane iron-sulfur flavoprotein NosR or the periplasmic protein NosX, a member of the ApbE family, abolishes N2O respiration. Here we demonstrate through biochemical and structural studies that the ApbE protein from Pseudomonas stutzeri, where the nosX gene is absent, is a monomeric FAD-binding protein that can serve as the flavin donor for NosR maturation via covalent flavinylation of a threonine residue. The flavin transfer reaction proceeds both in vivo and in vitro to generate post-translationally modified NosR with covalently bound FMN. Only FAD can act as substrate and the reaction requires a divalent cation, preferably Mg(2+) that was also present in the crystal structure. In addition, the reaction is species-specific to a certain extent.

  9. The School Library Vertical File.

    ERIC Educational Resources Information Center

    Smallwood, Carol

    1990-01-01

    Discusses the maintenance of vertical files in the school library. Topics covered include circulation, weeding, using materials for special displays, acquiring materials, policies on advertising and controversial issues, cross-references, subject headings, introducing students to vertical files, beginning a collection, and preservation. (MES)

  10. Portable File Format (PFF) specifications

    SciTech Connect

    Dolan, Daniel H.

    2015-02-01

    Created at Sandia National Laboratories, the Portable File Format (PFF) allows binary data transfer across computer platforms. Although this capability is supported by many other formats, PFF files are still in use at Sandia, particularly in pulsed power research. This report provides detailed PFF specifications for accessing data without relying on legacy code.

  11. The DNA Files

    SciTech Connect

    1998-06-09

    The DNA Files is a radio documentary which disseminates genetics information over public radio. The documentaries explore subjects which include the following: How genetics affects society. How human life began and how it evolved. Could new prenatal genetic tests hold the key to disease prevention later in life? Would a national genetic data base sacrifice individual privacy? and Should genes that may lead to the cure for cancer be privately owned? This report serves as a project update for the second quarter of 1998. It includes the spring/summer 1998 newsletter, the winter 1998 newsletter, the program clock, and the latest flyer.

  12. Using a Professional Development Program for Enhancing Chilean Biology Teachers' Understanding of Nature of Science (NOS) and Their Perceptions About Using History of Science to Teach NOS

    NASA Astrophysics Data System (ADS)

    Pavez, José M.; Vergara, Claudia A.; Santibañez, David; Cofré, Hernán

    2016-05-01

    A number of authors have recognized the importance of understanding the nature of science (NOS) for scientific literacy. Different instructional strategies such as decontextualized, hands-on inquiry, and history of science (HOS) activities have been proposed for teaching NOS. This article seeks to understand the contribution of HOS in enhancing biology teachers' understanding of NOS, and their perceptions about using HOS to teach NOS. These teachers ( N = 8), enrolled in a professional development program in Chile are, according to the national curriculum, expected to teach NOS, but have no specific NOS and HOS training. Teachers' views of NOS were assessed using the VNOS-D+ questionnaire at the beginning and at the end of two modules about science instruction and NOS. Both the pre- and the post-test were accompanied by interviews, and in the second session we collected information about teachers' perceptions of which interventions had been more significant in changing their views on NOS. Finally, the teachers also had to prepare a lesson plan for teaching NOS that included HOS. Some of the most important study results were: significant improvements were observed in teachers' understanding of NOS, although they assigned different levels of importance to HOS in these improvements; and although the teachers improved their understanding of NOS, most had difficulties in planning lessons about NOS and articulating historical episodes that incorporated NOS. The relationship between teachers' improved understanding of NOS and their instructional NOS skills is also discussed.

  13. Defining viral species: making taxonomy useful.

    PubMed

    Peterson, A Townsend

    2014-07-23

    Virus taxonomy at present is best characterized as a categorization of convenience, without a firm basis in the principles of evolutionary biology. Specifically, virus species definitions appear to depend more on tradition and popular opinion among virologists than on firm, quantitative biological evidence. I suggest a series of changes to underlying species concepts that would shift the field from one that simply files viruses away in taxonomic boxes to one that can learn important biological lessons from its taxonomy.

  14. 11 CFR 100.19 - File, filed or filing (2 U.S.C. 434(a)).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... to be filed under 11 CFR parts 101, 102, 104, 105, 107, 108, and 109, and any modifications or...) Where to deliver reports. Except for documents electronically filed under paragraph (c) of this section...., Washington, DC 20463; or the Secretary of the United States Senate, Office of Public Records, 119 D Street...

  15. Regulation of eNOS enzyme activity by posttranslational modification.

    PubMed

    Heiss, Elke H; Dirsch, Verena M

    2014-01-01

    The regulation of endothelial NO synthase (eNOS) employs multiple different cellular control mechanisms impinging on level and activity of the enzyme. This review aims at summarizing the current knowledge on the posttranslational modifications of eNOS, including acylation, nitrosylation, phosphorylation, acetylation, glycosylation and glutathionylation. Sites, mediators and impact on enzyme localization and activity of the single modifications will be discussed. Moreover, interdependence, cooperativity and competition between the different posttranslational modifications will be elaborated with special emphasis on the susceptibility of eNOS to metabolic cues.

  16. Mitochondrial metabolic states and membrane potential modulate mtNOS activity.

    PubMed

    Valdez, Laura B; Zaobornyj, Tamara; Boveris, Alberto

    2006-03-01

    The mitochondrial metabolic state regulates the rate of NO release from coupled mitochondria: NO release by heart, liver and kidney mitochondria was about 40-45% lower in state 3 (1.2, 0.7 and 0.4 nmol/min mg protein) than in state 4 (2.2, 1.3 and 0.7 nmol/min mg protein). The activity of mtNOS, responsible for NO release, appears driven by the membrane potential component and not by intramitochondrial pH of the proton motive force. The intramitochondrial concentrations of the NOS substrates, L-arginine (about 310 microM) and NADPH (1.04-1.78 mM) are 60-1000 times higher than their KM values. Moreover, the changes in their concentrations in the state 4-state 3 transition are not enough to explain the changes in NO release. Nitric oxide release was exponentially dependent on membrane potential as reported for mitochondrial H2O2 production [S.S. Korshunov, V.P. Skulachev, A.A. Satarkov, High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. FEBS Lett. 416 (1997) 15-18.]. Agents that decrease or abolish membrane potential minimize NO release while the addition of oligomycin that produces mitochondrial hyperpolarization generates the maximal NO release. The regulation of mtNOS activity, an apparently voltage-dependent enzyme, by membrane potential is marked at the physiological range of membrane potentials.

  17. Association of common eNOS/NOS3 polymorphisms with preeclampsia in Tunisian Arabs.

    PubMed

    Ben Ali Gannoun, Marwa; Zitouni, Hedia; Raguema, Nozha; Maleh, Wided; Gris, Jean-Christophe; Almawi, Wassim; Mahjoub, Touhami

    2015-09-15

    We investigated the association of endothelial nitric oxide synthase (NOS3) polymorphisms -786T>C, 27-bp repeat 4b/4a, and Glu298Asp with preeclampsia (PE). This was a case-control study involving 345 unrelated Tunisian women with PE and 289 unrelated age- and ethnically matched control women. The -786C allele was significantly increased in PA patients when compared to healthy controls (P=0.015). In contrast, MAF of Glu298Asp (P=0.103) and 4b/4a (P=0.168) were not significantly different between the study groups. Higher frequencies of heterozygous Glu298/298Asp and homozygous -786T/-786T genotypes were seen in PE cases compared to healthy subjects. The combination of genotypes 221 (-786T>C, Glu298Asp, 4a/4a) was more in PE cases compared with control women (17.68% vs. 8.36%; P=0.029). Multivariate regression analysis confirmed this association. Genetic variation at the NOS3 locus represents a genetic risk factor for increased susceptibility to PE.

  18. 78 FR 27372 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-10

    ... 2013 Filing to be effective 8/ 1/2013. Filed Date: 5/1/13. Accession Number: 20130501-5062. Comments Due: 5 p.m. ET 5/13/13. Docket Numbers: RP13-863-000. Applicants: Big Sandy Pipeline, LLC. Description: FOSA Modifications May 2013 Filing to be effective 8/ 1/2013. Filed Date: 5/1/13. Accession...

  19. 76 FR 6611 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-07

    .... Description: Williston Basin Interstate Pipeline Company submits tariff filing per 154.204: Non-Conforming... tariff filing per 154.204: Non-Conforming Agreement--Chevron 1-26-11 to be effective 2/1/2011. Filed Date... tariff filing per 154.204: Incorporation of Previously Accepted Tariff Provisions to be effective...

  20. 12 CFR 1102.24 - Filing requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 9 2012-01-01 2012-01-01 false Filing requirements. 1102.24 Section 1102.24 Banks and Banking FEDERAL FINANCIAL INSTITUTIONS EXAMINATION COUNCIL APPRAISER REGULATION Rules of Practice for Proceedings § 1102.24 Filing requirements. (a) Filing. All papers filed with the ASC in...

  1. 12 CFR 303.121 - Filing procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Filing procedures. 303.121 Section 303.121 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE FILING PROCEDURES Activities of Insured State Banks § 303.121 Filing procedures. (a) Where to file. A notice...

  2. 12 CFR 303.201 - Filing procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Filing procedures. 303.201 Section 303.201 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE FILING PROCEDURES Prompt Corrective Action § 303.201 Filing procedures. Applications shall be filed with...

  3. 77 FR 27044 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-08

    ... Pipeline Company, LP submits tariff filing per 154.204: HK 37731 to Sequent 39880 Capacity Release... Capacity Release Negotiated Rate Agreement filing to be effective 5/1/2012. Filed Date: 4/30/12. Accession....204: HK 37731 to Texla 39887 Capacity Release Negotiated Rate Agreement filing to be effective...

  4. 48 CFR 1404.802 - Contract files.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract files. 1404.802 Section 1404.802 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR GENERAL ADMINISTRATIVE MATTERS Contract Files 1404.802 Contract files. In addition to the requirements in FAR 4.802, files...

  5. 12 CFR 11.4 - Filing fees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 1 2011-01-01 2011-01-01 false Filing fees. 11.4 Section 11.4 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY SECURITIES EXCHANGE ACT DISCLOSURE RULES § 11.4 Filing fees. (a) The OCC may require filing fees to accompany certain filings made under...

  6. 76 FR 1422 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-10

    ... has received the following Natural Gas Pipeline Rate and Refund Report filings: Docket Numbers: RP11... submits tariff filing per 154.312: General Section 4 Rate Case to be effective 2/1/ 2011. Filed Date: 12...: Iroquois Gas Transmission System, L.P. submits tariff filing per 154.204: 12/30/10 Negotiated...

  7. 76 FR 79169 - Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-21

    ... filing per 35.13(a)(2)(iii): Corn Belt Agreements to be effective 2/13/2012. Filed Date: 12/12/11....ferc.gov/docs-filing/efiling/filing-req.pdf . For other information, call (866) 208-3676 (toll...

  8. 77 FR 56197 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-12

    ... received the following Natural Gas Pipeline Rate and Refund Report filings: Filings Instituting Proceedings Docket Numbers: RP11-2473-000. Applicants: Gulf South Pipeline Company, LP. Description: Annual Cash-In/Cash-Out Filing--2012. Filed Date: 8/31/12. Accession Number: 20120831-5044. Comments Due: 5 p.m. ET...

  9. 48 CFR 204.802 - Contract files.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract files. 204.802... OF DEFENSE GENERAL ADMINISTRATIVE MATTERS Contract Files 204.802 Contract files. Official contract files shall consist of— (1) Only original, authenticated or conformed copies of contractual...

  10. 10 CFR 603.1020 - File documents.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false File documents. 603.1020 Section 603.1020 Energy... Reporting Information About the Award § 603.1020 File documents. The award file should include an analysis..., the file must document the analysis required (see § 603.560) to set the fixed level of Federal...

  11. Tropospheric Emission Spectrometer Product File Readers

    NASA Technical Reports Server (NTRS)

    Fisher, Brendan M.

    2010-01-01

    TES Product File Reader software extracts data from publicly available Tropospheric Emission Spectrometer (TES) HDF (Hierarchical Data Format) product data files using publicly available format specifications for scientific analysis in IDL (interactive data language). In this innovation, the software returns data fields as simple arrays for a given file. A file name is provided, and the contents are returned as simple IDL variables.

  12. 18 CFR 1308.27 - Appeal files.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Appeal files. 1308.27... Board of Contract Appeals § 1308.27 Appeal files. (a) Notices of appeal shall be filed as provided in... an appeal file consisting of: (1) The Contracting Officer's decision, if any, from which the...

  13. 50 CFR 20.155 - Public file.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Public file. 20.155 Section 20.155... § 20.155 Public file. (a) Establishment. A public file will be established for each rulemaking to which.... 552, a public file established pursuant to paragraph (a) of this section will contain: (1) The...

  14. 47 CFR 1.1704 - Station files.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Station files. 1.1704 Section 1.1704... System (COALS) § 1.1704 Station files. Applications, notifications, correspondence, electronic filings.... These files constitute the official records for these stations and supersede any other records,...

  15. 75 FR 47296 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-05

    ...: Negative Rate 2010-07-28 to be effective 8/1/2010. Filed Date: 07/28/2010. Accession Number: 20100728-5157... has received the following Natural Gas Pipeline Rate and Refund Report filings: Docket Numbers: RP10....203: Baseline Filing and Amendment to Non-Conf Agmt and Negotiated Rate Agmt Filing to be effective...

  16. Molecular characterization of nosRZDFYLX genes coding for denitrifying nitrous oxide reductase of Bradyrhizobium japonicum.

    PubMed

    Velasco, Leonardo; Mesa, Socorro; Xu, Chang-Ai; Delgado, María J; Bedmar, Eulogio J

    2004-04-01

    The nosRZDFYLX gene cluster for the respiratory nitrous oxide reductase from Bradyrhizobium japonicum strain USDA110 has been cloned and sequenced. Seven protein coding regions corresponding to nosR, nosZ, the structural gene, nosD, nosF, nosY, nosL, and nosX were detected. The deduced amino acid sequence exhibited a high degree of similarity to other nitrous oxide reductases from various sources. The NosZ protein included a signal peptide for protein export. Mutant strains carrying either a nosZ or a nosR mutation accumulated nitrous oxide when cultured microaerobically in the presence of nitrate. Maximal expression of a P nosZ-lacZ fusion in strain USDA110 required simultaneously both low level oxygen conditions and the presence of nitrate. Microaerobic activation of the fusion required FixLJ and FixK(2).

  17. 75 FR 42435 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-21

    .... Applicants: Entergy Arkansas, Inc. Description: Entergy Arkansas, Inc. submits tariff filing per 35.12: MBR... filing per 35.12: MBR and CBR Baseline Filing to be effective 7/14/ 2010. Filed Date: 07/14/2010... filing per 35.12: MBR and CBR Baseline Filing to be effective 7/14/2010. Filed Date:...

  18. 21 CFR 516.163 - Change in ownership of an index file.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS NEW ANIMAL DRUGS FOR MINOR USE AND MINOR SPECIES Index of Legally Marketed Unapproved New Animal Drugs for Minor Species § 516.163 Change in ownership of an... owner shall submit in writing to FDA a statement that all rights in the index file have been...

  19. 21 CFR 516.163 - Change in ownership of an index file.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS NEW ANIMAL DRUGS FOR MINOR USE AND MINOR SPECIES Index of Legally Marketed Unapproved New Animal Drugs for Minor Species § 516.163 Change in ownership of an... owner shall submit in writing to FDA a statement that all rights in the index file have been...

  20. The effect of high protein diet and exercise on irisin, eNOS, and iNOS expressions in kidney.

    PubMed

    Tastekin, Ebru; Palabiyik, Orkide; Ulucam, Enis; Uzgur, Selda; Karaca, Aziz; Vardar, Selma Arzu; Yilmaz, Ali; Aydogdu, Nurettin

    2016-08-01

    Long-term effects of high protein diets (HPDs) on kidneys are still not sufficiently studied. Irisin which increases oxygen consumption and thermogenesis in white fat cells was shown in skeletal muscles and many tissues. Nitric oxide synthases (NOS) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. We aimed to investigate the effects of HPD, irisin and NO expression in kidney and relation of them with exercise and among themselves. Animals were grouped as control, exercise, HPD and exercise combined with HPD (exercise-HPD). Rats were kept on a HPD for 5 weeks and an exercise program was given them as 5 exercise and 2 rest days per week exercising on a treadmill with increasing speed and angle. In our study, while HPD group had similar total antioxidant capacity (TAC) levels with control group, exercise and exercise-HPD groups had lower levels (p < 0.05). Kidneys of exercising rats had no change in irisin or eNOS expression but their iNOS expression had increased (p < 0.001). HPD-E group has not been observed to cause kidney damage and not have a significant effect on rat kidney irisin, eNOS, or iNOS expression. Localization of irisin, eNOS, and iNOS staining in kidney is highly selective and quite clear in this study. Effects of exercise and HPD on kidney should be evaluated with different exercise protocols and contents of the diet. İrisin, eNOS, and iNOS staining localizations should be supported with various research studies.

  1. eNOS/iNOS and endoplasmic reticulum stress-induced apoptosis in the placentas of patients with preeclampsia

    PubMed Central

    Du, L; He, F; Kuang, L; Tang, W; Li, Y; Chen, D

    2017-01-01

    Disruption of nitric oxide pathway and endoplasmic reticulum (ER) stress had been observed in preeclampsia (PE). However, the correlation and overall detailed expression profiles of ER stress-related markers and endothelial nitric oxide synthase/inducible nitric oxide synthase (eNOS/iNOS) in patients with PE were poorly understood. In this study, placental protein expression of ER stress-related markers as well as eNOS/iNOS in normotensive control (n=32) and PE pregnancies (n=32) was examined by western blot. In addition, apoptosis was detected by terminal deoxynucleotidyl transferase-mediated nick-end labelling (TUNEL) staining in placentas. Compared with control, we found elevated ER stress response was agreeable with iNOS upregulation in placenta tissue of PE patients. Placental protein expression of ER stress-related markers, including GRP78, GRP94, p-PERK, eIF2a, p-eIF2a, XBP1, CHOP, Ire1, p-Ire1 and iNOS, was higher, and eNOS expression was lower in PE (P<0.05 for all); however, the expression of ATF6 and PERK was similar in the PE and control groups. Upregulation of CHOP and iNOS was consistent of apoptosis increasing indicated by TUNEL staining and caspase 4 expression upregulation in PE placenta. Our datas suggest that the exaggerated ER stress response and upregulated iNOS are probably associated with increased apoptosis in placenta of PE patients and may contribute to the pathophysiology of PE. PMID:27030287

  2. Differential roles of iNOS and nNOS at rostral ventrolateral medulla during experimental endotoxemia in the rat.

    PubMed

    Chan, J Y; Wang, S H; Chan, S H

    2001-01-01

    We investigated the differential contribution of inducible and neuronal nitric oxide synthase (iNOS and nNOS) at the rostral ventrolateral medulla (RVLM) to endotoxemia induced by E. coli lipopolysaccharide (LPS). In Sprague-Dawley rats maintained under propofol anesthesia, i.v. administration of LPS (15, 30, or 45 mg/kg) induced a reduction (phase I), followed by an augmentation (phase II) and a secondary decrease (phase III) in the power density of the vasomotor components (0-0.8 Hz) in systemic arterial pressure (SAP) signals. LPS also induced an immediate hypotension, followed by a rebound increase and a secondary decrease in SAP. In addition, the level of iNOS mRNA exhibited a significant surge that began with phase I endotoxemia, reaching progressively its peak at phase III. Discernible down-regulation of nNOS mRNA was not detected until the last phase of endotoxemia. Pretreatment with microinjection of the selective iNOS inhibitor, aminoguanidine (250 pmol), into the bilateral RVLM significantly prolonged phases II and III endotoxemia, blunted the initial and secondary hypotension, and antagonized the upregulation of iNOS mRNA. Similar pretreatment with the selective nNOS inhibitor, 7-nitroindazole (1 pmol), on the other hand, discernibly shortened phase II and prolonged phase III endotoxemia, and induced progressive hypotension by antagonizing the rebound increase in SAP. We conclude that the relative prevalence of functional expression and molecular synthesis of iNOS over nNOS in the RVLM may be a crucial determinant for the reduction or loss in power density of the vasomotor components of SAP signals during experimental endotoxemia.

  3. Invasive Species

    EPA Pesticide Factsheets

    Invasive species have significantly changed the Great Lakes ecosystem. An invasive species is a plant or animal that is not native to an ecosystem, and whose introduction is likely to cause economic, human health, or environmental damage.

  4. Virtual file system for PSDS

    NASA Technical Reports Server (NTRS)

    Runnels, Tyson D.

    1993-01-01

    This is a case study. It deals with the use of a 'virtual file system' (VFS) for Boeing's UNIX-based Product Standards Data System (PSDS). One of the objectives of PSDS is to store digital standards documents. The file-storage requirements are that the files must be rapidly accessible, stored for long periods of time - as though they were paper, protected from disaster, and accumulative to about 80 billion characters (80 gigabytes). This volume of data will be approached in the first two years of the project's operation. The approach chosen is to install a hierarchical file migration system using optical disk cartridges. Files are migrated from high-performance media to lower performance optical media based on a least-frequency-used algorithm. The optical media are less expensive per character stored and are removable. Vital statistics about the removable optical disk cartridges are maintained in a database. The assembly of hardware and software acts as a single virtual file system transparent to the PSDS user. The files are copied to 'backup-and-recover' media whose vital statistics are also stored in the database. Seventeen months into operation, PSDS is storing 49 gigabytes. A number of operational and performance problems were overcome. Costs are under control. New and/or alternative uses for the VFS are being considered.

  5. Interior view of connector between Building Nos. 608 & 609 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Interior view of connector between Building Nos. 608 & 609 (HABS CO-172-DS) facing north - Fitzsimons General Hospital, Neuropsychiatric Ward, Southeast Corner of East Nineteenth Avenue & Wheeling Street (formerly South Van Valzuh Street), Aurora, Adams County, CO

  6. Los Angeles County Poor Farm, Patient Ward Nos. 210 & ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Los Angeles County Poor Farm, Patient Ward Nos. 210 & 211 - Type B Plan, 7601 Imperial Highway; bounded by Esperanza Street, Laurel Street, Flores Street, and Descanso Street, Downey, Los Angeles County, CA

  7. 5. VIEW OF NORTH SECTION OF STRUCTURE SHOWING BRIDGE NOS. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. VIEW OF NORTH SECTION OF STRUCTURE SHOWING BRIDGE NOS. 10 AND 9 FROM CENTRAL STAIRWAY. LOOKING NORTH. - Greenville Yard, Transfer Bridge System, Port of New York/New Jersey, Upper New York Bay, Jersey City, Hudson County, NJ

  8. 6. VIEW OF SOUTH SECTION OF STRUCTURE SHOWING BRIDGE NOS. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. VIEW OF SOUTH SECTION OF STRUCTURE SHOWING BRIDGE NOS. 12, 13, AND 14 FROM CENTRAL STAIRWAY. LOOKING SOUTH. - Greenville Yard, Transfer Bridge System, Port of New York/New Jersey, Upper New York Bay, Jersey City, Hudson County, NJ

  9. 9. DETAIL OF BENTS NOS 3 AND 4. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. DETAIL OF BENTS NOS 3 AND 4. VIEW TO NORTH-NORTHEAST - Milwaukee Road Railroad Overpass, Spanning Chicago, Milwaukee, St. Paul, & Pacific Railroad Grade (Milwaukee Road) at Orange Street, Missoula, Missoula County, MT

  10. 11. BENTS NOS. 3 AND 2. VIEW TO SOUTHSOUTHWEST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. BENTS NOS. 3 AND 2. VIEW TO SOUTH-SOUTHWEST - Milwaukee Road Railroad Overpass, Spanning Chicago, Milwaukee, St. Paul, & Pacific Railroad Grade (Milwaukee Road) at Orange Street, Missoula, Missoula County, MT

  11. Vault Area (original section), east corridor, looking north (Vault Nos. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Vault Area (original section), east corridor, looking north (Vault Nos. 1-9 - Fort McNair, Film Store House, Fort Lesley J. McNair, P Street between Third & Fourth Streets, Southwest, Washington, District of Columbia, DC

  12. 36. ISLAND PLANT: Nos. 1 AND 2 TWENTYSIX INCH HORIZONTAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    36. ISLAND PLANT: Nos. 1 AND 2 TWENTY-SIX INCH HORIZONTAL SAMSON TURBINES - American Falls Water, Power & Light Company, Island Power Plant, Snake River, below American Falls Dam, American Falls, Power County, ID

  13. 37. ISLAND PLANT: Nos. 1 AND 2 TWENTYSIX INCH SPECIAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    37. ISLAND PLANT: Nos. 1 AND 2 TWENTY-SIX INCH SPECIAL HORIZONTAL SAMSON TURBINE (RIVITED CASE) - American Falls Water, Power & Light Company, Island Power Plant, Snake River, below American Falls Dam, American Falls, Power County, ID

  14. The Brain NO Levels and NOS Activities Ascended in the Early and Middle Stages and Descended in the Terminal Stage in Scrapie-Infected Animal Models.

    PubMed

    Chen, Li-Na; Sun, Jing; Yang, Xiao-Dong; Xiao, Kang; Lv, Yan; Zhang, Bao-Yun; Zhou, Wei; Chen, Cao; Gao, Chen; Shi, Qi; Dong, Xiao-Ping

    2017-04-01

    The infections of prion agents may cause progressive and fatal neurodegenerative diseases in humans and a serial of animal species. Previous studies have proposed that the levels of nitric oxide (NO) and nitric oxide synthase (NOS) in the brains of some neurodegeneration diseases changed, while S-nitrosylation (SNO) of many brain proteins altered in prion diseases. To elucidate the potential changes of brain NO levels during prion infection, the NO levels and NOS activities in the brain tissues of three scrapie experimental rodents were measured, including scrapie agent 263 K-infected hamsters and 139A- and ME7-infected mice. Both NO levels and NOS activities, including total NOS (TNOS) and inducible NOS (iNOS), were increased at the terminal stages of scrapie-infected animals. Assays of the brain samples collected at different time points during scrapie infection showed that the NO levels and NOS activities started to increase at early stage, reached to the peak in the middle stage, and dropped down at late stage. Western blots for brain iNOS revealed increased firstly and decreased late, especially in the brains of 139A- and ME7-infected mice. In line with those alterations, the levels of the SNO forms of several selected brain proteins such as aquaporin-1 (AQP1), calcium/calmodulin-dependent protein kinase II (CaMKII), neurogranin, and opalin, underwent similar changing trends, while their total protein levels did not change obviously during scrapie infection. Our data here for the first time illustrate the changing profile of brain NO and NOS during prion infection. Time-dependent alterations of brain NO level and the associated protein S-nitrosylation process may contribute greatly to the neuropathological damage in prion diseases.

  15. Investigating the Role of TNF-α and IFN-γ Activation on the Dynamics of iNOS Gene Expression in LPS Stimulated Macrophages

    PubMed Central

    Salim, Taha; Sershen, Cheryl L.; May, Elebeoba E.

    2016-01-01

    Macrophage produced inducible nitric oxide synthase (iNOS) is known to play a critical role in the proinflammatory response against intracellular pathogens by promoting the generation of bactericidal reactive nitrogen species. Robust and timely production of nitric oxide (NO) by iNOS and analogous production of reactive oxygen species are critical components of an effective immune response. In addition to pathogen associated lipopolysaccharides (LPS), iNOS gene expression is dependent on numerous proinflammatory cytokines in the cellular microenvironment of the macrophage, two of which include interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α). To understand the synergistic effect of IFN-γ and TNF-α activation, and LPS stimulation on iNOS expression dynamics and NO production, we developed a systems biology based mathematical model. Using our model, we investigated the impact of pre-infection cytokine exposure, or priming, on the system. We explored the essentiality of IFN-γ priming to the robustness of initial proinflammatory response with respect to the ability of macrophages to produce reactive species needed for pathogen clearance. Results from our theoretical studies indicated that IFN-γ and subsequent activation of IRF1 are essential in consequential production of iNOS upon LPS stimulation. We showed that IFN-γ priming at low concentrations greatly increases the effector response of macrophages against intracellular pathogens. Ultimately the model demonstrated that although TNF-α contributed towards a more rapid response time, measured as time to reach maximum iNOS production, IFN-γ stimulation was significantly more significant in terms of the maximum expression of iNOS and the concentration of NO produced. PMID:27276061

  16. Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis

    PubMed Central

    Stadler, Krisztian; Bonini, Marcelo G.; Dallas, Shannon; Duma, Danielle; Mason, Ronald P.; Kadiiska, Maria B.

    2008-01-01

    Diabetic patients frequently encounter ketosis that is characterized by the breakdown of lipids with the consequent accumulation of ketone bodies. Several studies have demonstrated that reactive species are likely to induce tissue damage in diabetes, but the role of the ketone bodies in the process has not been fully investigated. In this study, electron paramagnetic resonance (EPR) spectroscopy combined with novel spin-trapping and immunological techniques has been used to investigate in vivo free radical formation in a murine model of acetone-induced ketosis. A six-line EPR spectrum consistent with the α-(4-pyridyl-1-oxide)-N-t-butylnitrone radical adduct of a carbon-centered lipid-derived radical was detected in the liver extracts. To investigate the possible enzymatic source of these radicals, inducible nitric oxide synthase (iNOS) and NADPH oxidase knockout mice were used. Free radical production was unchanged in the NADPH oxidase knockout but much decreased in the iNOS knockout mice, suggesting a role for iNOS in free radical production. Longer-term exposure to acetone revealed iNOS overexpression in the liver together with protein radical formation, which was detected by confocal microscopy and a novel immunospin-trapping method. Immunohistochemical analysis revealed enhanced lipid peroxidation and protein oxidation as a consequence of persistent free radical generation after 21 days of acetone treatment in control and NADPH oxidase knockout but not in iNOS knockout mice. Taken together, our data demonstrate that acetone administration, a model of ketosis, can lead to protein oxidation and lipid peroxidation through a free radical-dependent mechanism driven mainly by iNOS overexpression. PMID:18559982

  17. Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis.

    PubMed

    Stadler, Krisztian; Bonini, Marcelo G; Dallas, Shannon; Duma, Danielle; Mason, Ronald P; Kadiiska, Maria B

    2008-08-01

    Diabetic patients frequently encounter ketosis that is characterized by the breakdown of lipids with the consequent accumulation of ketone bodies. Several studies have demonstrated that reactive species are likely to induce tissue damage in diabetes, but the role of the ketone bodies in the process has not been fully investigated. In this study, electron paramagnetic resonance (EPR) spectroscopy combined with novel spin-trapping and immunological techniques has been used to investigate in vivo free radical formation in a murine model of acetone-induced ketosis. A six-line EPR spectrum consistent with the alpha-(4-pyridyl-1-oxide)-N-t-butylnitrone radical adduct of a carbon-centered lipid-derived radical was detected in the liver extracts. To investigate the possible enzymatic source of these radicals, inducible nitric oxide synthase (iNOS) and NADPH oxidase knockout mice were used. Free radical production was unchanged in the NADPH oxidase knockout but much decreased in the iNOS knockout mice, suggesting a role for iNOS in free radical production. Longer-term exposure to acetone revealed iNOS overexpression in the liver together with protein radical formation, which was detected by confocal microscopy and a novel immunospin-trapping method. Immunohistochemical analysis revealed enhanced lipid peroxidation and protein oxidation as a consequence of persistent free radical generation after 21 days of acetone treatment in control and NADPH oxidase knockout but not in iNOS knockout mice. Taken together, our data demonstrate that acetone administration, a model of ketosis, can lead to protein oxidation and lipid peroxidation through a free radical-dependent mechanism driven mainly by iNOS overexpression.

  18. 43 CFR 4.1391 - Who may file; where to file; when to file; filing of administrative record.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., 801 N. Quincy Street, Suite 300, Arlington, VA 22203 (telephone 703-235-3750). OSM shall file the complete administrative record of the determination under review with the Board as soon as practicable....

  19. FRS Geospatial Return File Format

    EPA Pesticide Factsheets

    The Geospatial Return File Format describes format that needs to be used to submit latitude and longitude coordinates for use in Envirofacts mapping applications. These coordinates are stored in the Geospatail Reference Tables.

  20. The beneficial effects of melatonin against heart mitochondrial impairment during sepsis: inhibition of iNOS and preservation of nNOS.

    PubMed

    Ortiz, Francisco; García, José A; Acuña-Castroviejo, Darío; Doerrier, Carolina; López, Ana; Venegas, Carmen; Volt, Huayqui; Luna-Sánchez, Marta; López, Luis C; Escames, Germaine

    2014-01-01

    While it is accepted that the high production of nitric oxide (NO˙) by the inducible nitric oxide synthase (iNOS) impairs cardiac mitochondrial function during sepsis, the role of neuronal nitric oxide synthase (nNOS) may be protective. During sepsis, there is a significantly increase in the expression and activity of mitochondrial iNOS (i-mtNOS), which parallels the changes in cytosolic iNOS. The existence of a constitutive NOS form (c-mtNOS) in heart mitochondria has been also described, but its role in the heart failure during sepsis remains unclear. Herein, we analyzed the changes in mitochondrial oxidative stress and bioenergetics in wild-type and nNOS-deficient mice during sepsis, and the role of melatonin, a known antioxidant, in these changes. Sepsis was induced by cecal ligation and puncture, and heart mitochondria were analyzed for NOS expression and activity, nitrites, lipid peroxidation, glutathione and glutathione redox enzymes, oxidized proteins, and respiratory chain activity in vehicle- and melatonin-treated mice. Our data show that sepsis produced a similar induction of iNOS/i-mtNOS and comparable inhibition of the respiratory chain activity in wild-type and in nNOS-deficient mice. Sepsis also increased mitochondrial oxidative/nitrosative stress to a similar extent in both mice strains. Melatonin administration inhibited iNOS/i-mtNOS induction, restored mitochondrial homeostasis in septic mice, and preserved the activity of nNOS/c-mtNOS. The effects of melatonin were unrelated to the presence or the absence of nNOS. Our observations show a lack of effect of nNOS on heart bioenergetic impairment during sepsis and further support the beneficial actions of melatonin in sepsis.

  1. In vitro and in vivo induction and activation of nNOS by LPS in oligodendrocytes

    PubMed Central

    Yao, SY.; Ljunggren-Rose, A.; Chandramohan, N.; Whetsell, W.O.; Sriram, S.

    2014-01-01

    There are currently four known isoforms of nitric oxide synthase (NOS). Of these, neuronal NOS (nNOS) is known to be present exclusively in neurons, endothelial NOS (eNOS) in vascular endothelium, while the inducible form of NOS (iNOS) is known to be activated in oligodendrocytes, astrocytes and microglia. The fourth isoform, mitochondrial NOS (mtNOS), represents a post translational modification of nNOS. Using western blotting and real time-PCR, we show induction and activation of nNOS following culture of oligodendrocyte progenitor cells (OPC) with lipopolysaccharide (LPS). Activation of nNOS results in accumulation of peroxynitrite and tyrosine nitration of proteins in oligodendrocytes resulting in reduced cell viability. Injection of LPS in vivo into the corpus callosum of rats leads to the development of extensive demyelination of the white matter tracts. Immunostaining of regions close to the injection site shows the presence of nNOS, but not iNOS, in oligodendrocytes. Neither iNOS nor nNOS was seen in astrocytes in areas of demyelination. These studies suggest that activation of nNOS in oligodendrocytes leads to oligodendrocyte injury resulting in demyelination. PMID:20724006

  2. Files in an Interactive Environment.

    DTIC Science & Technology

    1980-04-01

    programs that exploit the existing file system and leaves the limitations to be dealt with by the user. In contrast, in the VM/ CMS environment, almost all...described here have been implemented using SIMULA-67 in the VM/ CMS operating system . The code con- sists of approximately 1500 lines of SIMULA of which...the SIMULA run time system code which is inadequate in this environment and the SIMULA code makes it possible to associate CMS DD names with CMS files

  3. Directory of astronomical data files

    NASA Technical Reports Server (NTRS)

    1978-01-01

    This Directory of Astronomical Data Files was prepared by the Data Task Force of the Interagency Coordination Committee for Astronomy (ICCA) in cooperation with the National Space Science Data Center (NSSDC). The purpose of the Directory is to provide a listing which will enable a user to locate stellar and extragalactic data sources keyed along with sufficient descriptive information to permit him to assess the value of the files for his use as well as the status and availability of the compilations.

  4. 77 FR 54566 - Endangered Species; File No. 16134

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-05

    ... (Dermochelys coriacea), and loggerhead (Caretta caretta) sea turtles for purposes of scientific research... Kemp's ridley sea turtles in mid- Atlantic waters from North Carolina to New Jersey. The purposes of the research are to: (1) Update current knowledge of loggerhead and Kemp's ridley sea turtle...

  5. 78 FR 19217 - Endangered Species; File No. 16547-01

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ... above and below 22 parts per thousand salinity. Researchers are currently authorized to capture adult... telemetry tags dependent on the life stage (adult, sub-adult and juvenile) and the salinity level where... salinity level in the waters of Virginia and Maryland. All previous activities are authorized; however,...

  6. 77 FR 73024 - Endangered Species; File No. 16547-01

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-07

    ... parts per thousand salinity. Researchers are currently authorized to capture adult, juvenile and early..., sub-adult and juvenile) and the salinity level where captured; or ] also externally satellite tagged... with either internal or external telemetry tags without respect to salinity level of the Chesapeake...

  7. 77 FR 61745 - Endangered Species; File No. 16803

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-11

    ... of scientific research. ADDRESSES: The permit and related documents are available for review upon... Register (77 FR 34349) that a request for a scientific research permit to take loggerhead, green, and olive... Bay, California. The purpose of the work is to determine their abundance, size ranges, growth,...

  8. 75 FR 61424 - Endangered Species; File No. 15596

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-05

    ... sturgeon (Acipenser brevirostrum) for the purposes of enhancement. DATES: Written, telefaxed, or e-mail... educational display of five captive-bred, non-releaseable adult shortnose sturgeon. This display would be used to increase public awareness of the shortnose sturgeon and its status by educating the public...

  9. 75 FR 6184 - Endangered Species; File No. 14754

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-08

    ... form for a permit to import and take shortnose sturgeon (Acipenser brevirostrum) early life stages (ELS..., to conduct research on Atlantic and shortnose sturgeon. Dr. Wirgin is requesting to conduct a study to determine if early life-stages of Atlantic and shortnose sturgeon are sensitive to PCB...

  10. 78 FR 50396 - Endangered Species; File No. 17405

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-19

    ... endangered black abalone, specifically, identifying limitations to their reproduction (focusing on successful... from the wild, nor will animals be returned to the wild under the permit. All animals will come...

  11. 75 FR 11863 - Endangered Species; File No. 15135

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... endangered sea turtles for purposes of scientific research. DATES: Written, telefaxed, or e-mail comments... turtle bycatch. The research would involve testing modified large mesh (> 5 inches) commercial gillnets... promise for reducing sea turtle bycatch in another location. Two contracted commercial gillnet...

  12. 78 FR 26323 - Endangered Species; File No. 17183

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-06

    ...), hawksbill (Eretmochelys imbricata), and Kemp's ridley (Lepidochelys kempii) sea turtles for purposes of... ridley sea turtles had been submitted by the above-named individual. The requested permit has been issued... on the demographics and movements of green, loggerhead, hawksbill, and Kemp's ridley sea turtles...

  13. 76 FR 37327 - Endangered Species; File No. 16253

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-27

    ... turtles for scientific research. DATES: Written, telefaxed, or e-mail comments must be received on or..., loggerhead, green, hawksbill, olive ridley, and Kemp's ridley sea turtles in the Atlantic Ocean, Gulf of... commercial fishing gear to mitigate sea turtle interactions and capture under two projects, Project A...

  14. 76 FR 22677 - Endangered Species; File No. 14949

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-22

    ... issued a permit to take green (Chelonia mydas) and hawksbill (Eretmochelys imbricata) sea turtles for... sea turtles had been submitted by the above-named individual. The requested permit has been issued... and population dynamics of hawksbill and green turtles inhabiting the waters surrounding Puerto...

  15. 76 FR 23305 - Endangered Species; File No. 15672

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-26

    ... permit to take leatherback sea turtles (Dermochelys coriacea) for purposes of scientific research. DATES... characterize the distribution, movements and dive behavior of leatherback sea turtles in the waters of New... leatherback sea turtles annually. Researchers would use animals that have been disentangled from fishing...

  16. 78 FR 13642 - Endangered Species; File No. 17506

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-28

    ...), Kemp's ridley (Lepidochelys kempii), and leatherback (Dermochelys coriaceae) sea turtles for purposes... permit to continue to characterize the population of sea turtles that utilize the nearshore hard bottom reefs in Brevard County, FL. Up to 50 green and six loggerhead sea turtles would be tangle netted,...

  17. 76 FR 33245 - Endangered Species; File No. 15135

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-08

    ... Isle, NC 28594, has been issued a permit to take threatened and endangered sea turtles for purposes... Register (75 FR 11863) that a request for a scientific research permit to take sea turtles had been... determine if gear modifications can eliminate or reduce sea turtle bycatch. Two contracted...

  18. 76 FR 71515 - Endangered Species; File No. 16174

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-18

    ... turtles (Chelonia mydas) for the purposes of scientific research. ADDRESSES: The permit and related... research permit to take green sea turtles had been submitted by the above-named individual. The requested... juvenile green sea turtles to characterize abundance and distribution in nearshore developmental...

  19. 76 FR 22877 - Endangered Species; File No. 15566

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-25

    ... coriacea), and hawksbill (Eretmochelys imbricata) sea turtles for purposes of scientific research... a request for a scientific research permit to take sea turtles had been submitted by the applicant... turtle in order to assess temporal change in catch rates, size distributions, sex and genetic ratios,...

  20. 76 FR 58471 - Endangered Species; File No. 15634

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-21

    ... permit to take leatherback sea turtles (Dermochelys coriacea) for scientific research. DATES: Written... proposes to conduct research on leatherback sea turtles to continue long-term monitoring of their status... leatherbacks. Up to 55 sea turtles would be located annually through aerial surveys and subsequently...

  1. 78 FR 16255 - Endangered Species; File No. 17022

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-14

    ... Science Center (PIFSC; Samuel Pooley, Ph.D., Responsible Party), has been issued a permit to take green... (77 FR 37877) that a request for a scientific research permit to take green and hawksbill sea turtles... 222-226). The PIFSC is authorized to begin long-term monitoring of green and hawksbill sea turtles...

  2. 78 FR 44096 - Endangered Species; File No. 17381

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... granted a 5-year permit to continue long-term research on the demographics and movements of green... permit to take green (Chelonia mydas), loggerhead (Caretta caretta), hawksbill (Eretmochelys...

  3. 78 FR 39258 - Endangered Species; File No. 18069

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-01

    ...), loggerhead (Caretta caretta), green (Chelonia mydas), and hawksbill (Eretmochelys imbricata) sea turtles for... to 100 Kemp's ridley, 20 green, 30 loggerhead, and five hawksbill sea turtles annually by strike net... migrations, movements, home range, and habitat associations. Dated: June 25, 2013. P. Michael Payne,...

  4. 77 FR 37877 - Endangered Species; File No. 17022

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-25

    ... permit to take green (Chelonia mydas) and hawksbill (Eretmochelys imbricata) sea turtles for purposes of... permit to continue long- term monitoring of the status of green and hawksbill sea turtles in the remote U... estimate abundance, size ranges, health status, habitat use, foraging ecology, local movements,...

  5. 77 FR 67341 - Endangered Species; File No. 15809

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-09

    ... ecological movements of juvenile green and hawksbill sea turtles. Researchers would directly capture up to 40... in due form for a permit to take green (Chelonia mydas) and hawksbill (Eretmochelys imbricata) sea... applicant requests a 5-year permit to conduct research on green and hawksbill sea turtles around...

  6. 75 FR 71670 - Endangered Species; File No. 15606

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-24

    ... in Gulf of Mexico waters. The purposes of these projects are to: (1) Examine green sea turtle assemblages in sea grass habitats in Texas; (2) determine trends in seasonal abundance and movement of green... applied in due form for a permit to take green (Chelonia mydas), Kemp's ridley (Lepidochelys...

  7. 76 FR 34967 - Endangered Species; File No. 10027

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-15

    ... the permit holder to study the population biology and connectivity of green (Chelonia mydas) and... modification to their existing permit to increase the number of green sea turtles taken annually from 100 to 250 turtles per year. Of the total 250 green sea turtles, researchers request to increase the...

  8. 77 FR 39220 - Endangered Species; File No. 17183

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-02

    ... to continue long-term research on the demographics and movements of green, loggerhead, hawksbill, and... 110450, Gainesville, FL 32611, has applied in due form for a permit to take green (Chelonia mydas... broad-scale temporal and spatial patterns of sea turtle use and movement patterns. Researchers...

  9. 76 FR 20324 - Endangered Species; File No. 15606

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ... grass habitats off of Texas; (2) determine trends in seasonal abundance and movement of green, Kemp's... permit to take green (Chelonia mydas), Kemp's ridley (Lepidochelys kempii), loggerhead (Caretta caretta... for a scientific research permit to take green, Kemp's ] ridley, loggerhead, and hawksbill sea...

  10. 77 FR 72326 - Endangered Species; File No. 17381

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-05

    ... continue long-term research on the demographics and movements of green, loggerhead, hawksbill, and Kemp's... applied in due form for a permit to take green (Chelonia mydas), loggerhead (Caretta caretta), hawksbill... and movement patterns inside and outside the National Park; (2) examine diet through stable...

  11. 75 FR 60734 - Endangered Species; File No. 13599-01

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-01

    ... Lab and used to support law enforcement actions, research studies (primarily genetics), and outreach.... ACTION: Notice; issuance of permit modification. SUMMARY: Notice is hereby given that National Ocean..., Charleston, SC 29412, has been issued a modification to scientific research Permit No. 13599. ADDRESSES:...

  12. 78 FR 57132 - Endangered Species; File No. 16230

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-17

    ... on the NMFS Office of Protected Resources Web site at http://www.nmfs.noaa.gov/pr/permits/esa_review... deep water portions of the Pamlico Sound Gillnet Restricted Area (PSGNRA) and Oregon, Hatteras,...

  13. 75 FR 19363 - Endangered Species; File No. 14754

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-14

    ... 25,000 fertilized shortnose sturgeon eggs of Saint John River ancestry from Acadian Sturgeon and Caviar Inc., Saint John, NB, Canada. The initial proposed research will take place during two sampling.... Dated: April 7, 2010. Jolie Harrison, Acting Chief, Permits, Conservation and Education Division,...

  14. 77 FR 1062 - Endangered Species; File No. 16146

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-09

    ...Notice is hereby given that Kristen Hart, Ph.D., U.S. Geological Survey, Southeast Ecological Science Center, Davie Field Office, Davie, FL has been issued a permit to take loggerhead (Caretta caretta), green (Chelonia mydas), and hawksbill (Eretmochelys imbricata) sea turtles for the purposes of scientific...

  15. 75 FR 13255 - Endangered Species; File No. 15338

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-19

    ... Polytechnic Institute and State University (Virginia Tech), has applied in due form for a permit pursuant to... activities will be conducted under the direct supervision of scientific parties from Virginia Tech....

  16. 76 FR 4635 - Endangered Species; File No. 15552

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-26

    ...), loggerhead (Caretta caretta), Kemp's ridley (Lepidochelys kempii), olive ridley (Lepidochelys olivacea..., loggerhead, hawksbill, leatherback, Kemp's ridley, olive ridley, and unidentified hardshell sea turtles by... 120 olive ridley/ unknown hardshell sea turtles would be handled, identified, photographed,...

  17. 76 FR 45781 - Endangered Species; File No. 15552

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-01

    ...), Kemp's ridley (Lepidochelys kempii), olive ridley (Lepidochelys olivacea), leatherback (Dermochelys... a scientific research permit to take green, loggerhead, hawksbill, leatherback, Kemp's ridley, olive... monitor the take of green, loggerhead, hawksbill, leatherback, Kemp's ridley, olive ridley,...

  18. 75 FR 22106 - Endangered Species; File No. 14510

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-27

    ... (Chelonia mydas), loggerhead (Caretta caretta), olive ridley (Lepidochelys olivacea), and leatherback..., inject tetracycline, and release up to: ten green, one olive ridley, and three loggerhead sea turtles taken in power plant entrainments; four green, one olive ridley, one loggerhead, and two leatherback...

  19. 76 FR 77781 - Endangered Species; File No. 15802

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-14

    ... and Wildlife Conservation Commission, 100 Eighth Avenue SE, St. Petersburg, FL 33701 , has requested a... written request or by appointment in the following offices: Permits and Conservation Division, Office of... the Chief, Permits and Conservation Division By email to NMFS.Pr1Comments@noaa.gov (include the...

  20. 75 FR 9868 - Endangered Species; File No. 14622

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ... Fish and Wildlife Conservation Commission, Fish and Wildlife Research Institute, 370 Zoo Parkway... by appointment in the following offices: Permits, Conservation and Education Division, Office of... should be mailed to the Chief, Permits, Conservation and Education Division, F/PR1, Office of...

  1. 78 FR 57353 - Endangered Species; File No. 14726

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-18

    ... Blair Witherington, Ph.D., Florida Fish and Wildlife Conservation Commission, 9700 South A1A, Melbourne...: Permits and Conservation Division, Office of Protected Resources, NMFS, 1315 East-West Highway, Room 13705... application should be submitted to the Chief, Permits and Conservation Division, at the address listed...

  2. 77 FR 27718 - Endangered Species; File No. 15566

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-11

    ..., size distributions, sex and genetic ratios, and health of sea turtles. Captures occur annually in... subsample of animals are subject to barnacle, keratin, fecal, and tissue sampling, cloacal swabs,...

  3. 78 FR 6072 - Endangered Species; File No. 17095-01

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-29

    ... Holder to: Monitor shortnose and Atlantic sturgeon abundance and distribution through the Hudson River... and/or larvae (ELS) annually. To account for a higher than expected catch per tow sampling performed... Atlantic sturgeon captured over the permit life. The Permit Holder also requests that the...

  4. 78 FR 17359 - Endangered Species; File No. 17095-01

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-21

    ... abundance and distribution through the Hudson River Biological Monitoring Program (HRBMP) in the Hudson... than expected catch per tow sampling performed authorized under Permit No. 17095, the Permit Holder now... Permit Holder will also expand the sampling activities for juvenile, sub-adult and adult...

  5. VizieR Online Data Catalog: Namelists of variable stars Nos.67-73 (Khopolov+, 1985-97)

    NASA Astrophysics Data System (ADS)

    Kholopov, P. N.; Samus, N. N.; Kazarovets, E. V.; Perova, N. B.

    1997-09-01

    We present a computer-readable version of six Name-Lists of Variable Stars (Nos.67-72) published in the system introduced during the preparation of the 4th GCVS edition. For printed versions of these Name-Lists see IBVS No.2681,1985; No.3058,1987; No.3323,1989; No.3530,1990; No.3840,1993; No.4140,1995. The main body of the 4th GCVS edition is already available in computer-readable form (see , , ). There are 2735 stars in the Name-Lists Nos.67-72 (file "nl.dat"). The variables are arranged in the order of their names inside constellations. One star of the 67th Name-List (V1810 Cyg=No.67247) turned out to be non-existing, it has been excluded from the table. The identification table (file "ident.dat") and the list of references (file "ref.dat") follow. The total number of designated variable stars has now reached 31193. In the new computer-readable version 1.1 of the GCVS, vol. IV (catalog ), we now present identifications also for name-list stars. We make no special attempt to present the material in a completely homogeneous form. There happened minor style evolution from the 67th to the 70th Name-List: particularly, the 67th Name-List normally refers in the identification table only to the catalogues cited in the papers mentioned in the references in the files "nl.dat" and "ident.dat", and to the 70th Name-List it became a common practice to give more catalogue identifications. From the Name-List No.70, there is no completeness in identifications with the old catalogues of suspected variables (CSV), in many cases we consider the NSV identification sufficient. We also do not try to update the information of the older Name-Lists, we only put the information together and correct known mistakes. The corrections to the Name-Lists have been taken into account. It is necessary to reproduce here two remarks from forewords of the printed Name-Lists: Name-List No.69. In the case of the variable stars in the open cluster NGC 3766 (V843-V849 Cen

  6. Nitrous Oxide Reduction Kinetics Distinguish Bacteria Harboring Clade I NosZ from Those Harboring Clade II NosZ

    PubMed Central

    Nissen, Silke; Park, Doyoung; Sanford, Robert A.

    2016-01-01

    ABSTRACT Bacteria capable of reduction of nitrous oxide (N2O) to N2 separate into clade I and clade II organisms on the basis of nos operon structures and nosZ sequence features. To explore the possible ecological consequences of distinct nos clusters, the growth of bacterial isolates with either clade I (Pseudomonas stutzeri strain DCP-Ps1, Shewanella loihica strain PV-4) or clade II (Dechloromonas aromatica strain RCB, Anaeromyxobacter dehalogenans strain 2CP-C) nosZ with N2O was examined. Growth curves did not reveal trends distinguishing the clade I and clade II organisms tested; however, the growth yields of clade II organisms exceeded those of clade I organisms by 1.5- to 1.8-fold. Further, whole-cell half-saturation constants (Kss) for N2O distinguished clade I from clade II organisms. The apparent Ks values of 0.324 ± 0.078 μM for D. aromatica and 1.34 ± 0.35 μM for A. dehalogenans were significantly lower than the values measured for P. stutzeri (35.5 ± 9.3 μM) and S. loihica (7.07 ± 1.13 μM). Genome sequencing demonstrated that Dechloromonas denitrificans possessed a clade II nosZ gene, and a measured Ks of 1.01 ± 0.18 μM for N2O was consistent with the values determined for the other clade II organisms tested. These observations provide a plausible mechanistic basis for why the relative activity of bacteria with clade I nos operons compared to that of bacteria with clade II nos operons may control N2O emissions and determine a soil's N2O sink capacity. IMPORTANCE Anthropogenic activities, in particular fertilizer application for agricultural production, increase N2O emissions to the atmosphere. N2O is a strong greenhouse gas with ozone destruction potential, and there is concern that nitrogen may become the major driver of climate change. Microbial N2O reductase (NosZ) catalyzes N2O reduction to environmentally benign dinitrogen gas and represents the major N2O sink process. The observation that bacterial groups with clade I nosZ versus those

  7. 77 FR 48511 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-14

    ...: New York Independent System Operator, Inc. Description: NYISO Compliance Filing--Buyer-side Market... qualifying facilities filings can be found at: http://www.ferc.gov/docs-filing/efiling/filing-req.pdf ....

  8. 29 CFR 1978.103 - Filing of retaliation complaints.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) Nature of Filing. No particular form of complaint is required. A complaint may be filed orally or in... of filing. The time for filing a complaint may be tolled for reasons warranted by applicable case...

  9. 76 FR 4647 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-26

    ... submits tariff filing per 35: GMO OATT Baseline Compliance Filing to be effective 8/4/2010. Filed Date: 01... Wind Energy, LLC's Notice of Non-Material Change in Status. Filed Date: 01/18/2011. Accession...

  10. 78 FR 67355 - Combined Notice of Filings #2

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ... 205 Transmission Depreciation Rates 2013 Filing to be effective 1/1/2013. Filed Date: 10/31/13... Depreciation Rates 2013 Filing to be effective 1/1/2013. Filed Date: 10/31/13. Accession Number:...

  11. Modulating DDAH/NOS Pathway to Discover Vasoprotective Insulin Sensitizers

    PubMed Central

    Lai, Li; Ghebremariam, Yohannes T.

    2016-01-01

    Insulin resistance syndrome (IRS) is a configuration of cardiovascular risk factors involved in the development of metabolic disorders including type 2 diabetes mellitus. In addition to diet, age, socioeconomic, and environmental factors, genetic factors that impair insulin signaling are centrally involved in the development and exacerbation of IRS. Genetic and pharmacological studies have demonstrated that the nitric oxide (NO) synthase (NOS) genes are critically involved in the regulation of insulin-mediated glucose disposal. The generation of NO by the NOS enzymes is known to contribute to vascular homeostasis including insulin-mediated skeletal muscle vasodilation and insulin sensitivity. By contrast, excessive inhibition of NOS enzymes by exogenous or endogenous factors is associated with insulin resistance (IR). Asymmetric dimethylarginine (ADMA) is an endogenous molecule that competitively inhibits all the NOS enzymes and contributes to metabolic perturbations including IR. The concentration of ADMA in plasma and tissue is enzymatically regulated by dimethylarginine dimethylaminohydrolase (DDAH), a widely expressed enzyme in the cardiovascular system. In preclinical studies, overexpression of DDAH has been shown to reduce ADMA levels, improve vascular compliance, and increase insulin sensitivity. This review discusses the feasibility of the NOS/DDAH pathway as a novel target to develop vasoprotective insulin sensitizers. PMID:26770984

  12. Expression analysis of NOS family and HSP genes during thermal stress in goat ( Capra hircus)

    NASA Astrophysics Data System (ADS)

    Yadav, Vijay Pratap; Dangi, Satyaveer Singh; Chouhan, Vikrant Singh; Gupta, Mahesh; Dangi, Saroj K.; Singh, Gyanendra; Maurya, Vijay Prakash; Kumar, Puneet; Sarkar, Mihir

    2016-03-01

    Approximately 50 genes other than heat shock protein (HSP) expression changes during thermal stress. These genes like nitric oxide synthase (NOS) need proper attention and investigation to find out their possible role in the adaptation to thermal stress in animals. So, the present study was undertaken to demonstrate the expressions of inducible form type II NOS (iNOS), endothelial type III NOS (eNOS), constitutively expressed enzyme NOS (cNOS), HSP70, and HSP90 in peripheral blood mononuclear cells (PBMCs) during different seasons in Barbari goats. Real-time polymerase chain reaction, western blot, and immunocytochemistry were applied to investigate messenger RNA (mRNA) expression, protein expression, and immunolocalization of examined factors. The mRNA and protein expressions of iNOS, eNOS, cNOS, HSP70, and HSP90 were significantly higher ( P < 0.05) during peak summer, and iNOS and eNOS expressions were also observed to be significantly higher ( P < 0.05) during peak winter season as compared with moderate season. The iNOS, eNOS, cNOS, HSP70, and HSP90 were mainly localized in plasma membrane and cytoplasm of PBMCs. To conclude, data generated in the present study indicate the possible involvement of the NOS family genes in amelioration of thermal stress so as to maintain cellular integrity and homeostasis in goats.

  13. Expression analysis of NOS family and HSP genes during thermal stress in goat (Capra hircus).

    PubMed

    Yadav, Vijay Pratap; Dangi, Satyaveer Singh; Chouhan, Vikrant Singh; Gupta, Mahesh; Dangi, Saroj K; Singh, Gyanendra; Maurya, Vijay Prakash; Kumar, Puneet; Sarkar, Mihir

    2016-03-01

    Approximately 50 genes other than heat shock protein (HSP) expression changes during thermal stress. These genes like nitric oxide synthase (NOS) need proper attention and investigation to find out their possible role in the adaptation to thermal stress in animals. So, the present study was undertaken to demonstrate the expressions of inducible form type II NOS (iNOS), endothelial type III NOS (eNOS), constitutively expressed enzyme NOS (cNOS), HSP70, and HSP90 in peripheral blood mononuclear cells (PBMCs) during different seasons in Barbari goats. Real-time polymerase chain reaction, western blot, and immunocytochemistry were applied to investigate messenger RNA (mRNA) expression, protein expression, and immunolocalization of examined factors. The mRNA and protein expressions of iNOS, eNOS, cNOS, HSP70, and HSP90 were significantly higher (P < 0.05) during peak summer, and iNOS and eNOS expressions were also observed to be significantly higher (P < 0.05) during peak winter season as compared with moderate season. The iNOS, eNOS, cNOS, HSP70, and HSP90 were mainly localized in plasma membrane and cytoplasm of PBMCs. To conclude, data generated in the present study indicate the possible involvement of the NOS family genes in amelioration of thermal stress so as to maintain cellular integrity and homeostasis in goats.

  14. Pedagogical Reflections by Secondary Science Teachers at Different NOS Implementation Levels

    NASA Astrophysics Data System (ADS)

    Herman, Benjamin C.; Clough, Michael P.; Olson, Joanne K.

    2015-10-01

    This study investigated what 13 secondary science teachers at various nature of science (NOS) instruction implementation levels talked about when they reflected on their teaching. We then determined if differences exist in the quality of those reflections between high, medium, and low NOS implementers. This study sought to answer the following questions: (1) What do teachers talk about when asked general questions about their pedagogy and NOS pedagogy and (2) what qualitative differences, if any, exist within variables across teachers of varying NOS implementation levels? Evidence derived from these teachers' reflections indicated that self-efficacy and perceptions of general importance for NOS instruction were poor indicators of NOS implementation. However, several factors were associated with the extent that these teachers implemented NOS instruction, including the utility value they hold for NOS teaching, considerations of how people learn, understanding of NOS pedagogy, and their ability to accurately and deeply self-reflect about teaching. Notably, those teachers who effectively implemented the NOS at higher levels value NOS instruction for reasons that transcend immediate instructional objectives. That is, they value teaching NOS for achieving compelling ends realized long after formal schooling (e.g., lifelong socioscientific decision-making for civic reasons), and they deeply reflect about how to teach NOS by drawing from research about how people learn. Low NOS implementers' simplistic notions and reflections about teaching and learning appeared to be impeding factors to accurate and consistent NOS implementation. This study has implications for science teacher education efforts that promote NOS instruction.

  15. Pedagogical Reflections by Secondary Science Teachers at Different NOS Implementation Levels

    NASA Astrophysics Data System (ADS)

    Herman, Benjamin C.; Clough, Michael P.; Olson, Joanne K.

    2017-02-01

    This study investigated what 13 secondary science teachers at various nature of science (NOS) instruction implementation levels talked about when they reflected on their teaching. We then determined if differences exist in the quality of those reflections between high, medium, and low NOS implementers. This study sought to answer the following questions: (1) What do teachers talk about when asked general questions about their pedagogy and NOS pedagogy and (2) what qualitative differences, if any, exist within variables across teachers of varying NOS implementation levels? Evidence derived from these teachers' reflections indicated that self-efficacy and perceptions of general importance for NOS instruction were poor indicators of NOS implementation. However, several factors were associated with the extent that these teachers implemented NOS instruction, including the utility value they hold for NOS teaching, considerations of how people learn, understanding of NOS pedagogy, and their ability to accurately and deeply self-reflect about teaching. Notably, those teachers who effectively implemented the NOS at higher levels value NOS instruction for reasons that transcend immediate instructional objectives. That is, they value teaching NOS for achieving compelling ends realized long after formal schooling (e.g., lifelong socioscientific decision-making for civic reasons), and they deeply reflect about how to teach NOS by drawing from research about how people learn. Low NOS implementers' simplistic notions and reflections about teaching and learning appeared to be impeding factors to accurate and consistent NOS implementation. This study has implications for science teacher education efforts that promote NOS instruction.

  16. Gamma-decanolactone inhibits iNOS and TNF-alpha production by lipopolysaccharide-activated microglia in N9 cells.

    PubMed

    Pflüger, Pricila; Viau, Cassiana Macagnan; Coelho, Vanessa Rodrigues; Berwig, Natália Alice; Staub, Renata Bartolomeu; Pereira, Patrícia; Saffi, Jenifer

    2016-06-05

    Activated microglia that produce reactive nitrogen species (RNS), inflammatory factors, reactive oxygen species (ROS), and other neurovirulent factors may lead to the development of neurodegenerative diseases. Certain compounds can inhibit the activation of microglia. However, these mechanisms remain unclear. In the present study, we investigated the inhibitory effect of Gamma-decanolactone (GD) on the production of reactive oxygen species and inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS) - stimulated N9 murine microglial cells through the p38 MAPK signaling pathway. The results showed that GD attenuated the activation of N9 cells and inhibited intracellular reactive oxygen species and the expression of iNOS and TNF-α induced by LPS in the cells. In addition, GD blocked the phosphorylation of p38 and inhibited cleaved caspase-9 and DNA damage. These data indicate that GD has therapeutic potential for the treatment of neurodegenerative diseases, and that it exerts its effects by inhibiting inflammation.

  17. Usage analysis of user files in UNIX

    NASA Technical Reports Server (NTRS)

    Devarakonda, Murthy V.; Iyer, Ravishankar K.

    1987-01-01

    Presented is a user-oriented analysis of short term file usage in a 4.2 BSD UNIX environment. The key aspect of this analysis is a characterization of users and files, which is a departure from the traditional approach of analyzing file references. Two characterization measures are employed: accesses-per-byte (combining fraction of a file referenced and number of references) and file size. This new approach is shown to distinguish differences in files as well as users, which cam be used in efficient file system design, and in creating realistic test workloads for simulations. A multi-stage gamma distribution is shown to closely model the file usage measures. Even though overall file sharing is small, some files belonging to a bulletin board system are accessed by many users, simultaneously and otherwise. Over 50% of users referenced files owned by other users, and over 80% of all files were involved in such references. Based on the differences in files and users, suggestions to improve the system performance were also made.

  18. 12 CFR 1780.9 - Filing of papers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Filing of papers. 1780.9 Section 1780.9 Banks... papers. (a) Filing. Any papers required to be filed shall be addressed to the presiding officer and filed... Director or the presiding officer. All papers filed by electronic media shall also concurrently be filed...

  19. 12 CFR 1780.9 - Filing of papers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Filing of papers. 1780.9 Section 1780.9 Banks... papers. (a) Filing. Any papers required to be filed shall be addressed to the presiding officer and filed... Director or the presiding officer. All papers filed by electronic media shall also concurrently be filed...

  20. 78 FR 2979 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-15

    ... Biomass Power Ltd. Description: MBR Deficiency Filing to be effective 10/29/2012. Filed Date: 1/7/13...: DTE Stoneman, LLC. Description: MBR Deficiency Filing to be effective 10/29/2012. Filed Date: 1/7/13...: DTE Pontiac North, LLC. Description: MBR Deficiency Filing to be effective 10/29/2012. Filed Date:...

  1. 76 FR 59673 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-27

    ... Services, LLC submits tariff filing per 35.1: Major Energy Electric Services, LLC MBR Re-file to be.... Description: Respond Power, LLC submits tariff filing per 35.1: Respond Power, LLC MBR Re-file to be effective...., submits tariff filing per 35.1: Alternate Power Source, Inc. MBR Re-file to be effective 9/16/ 2011...

  2. 77 FR 35371 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-13

    .... Description: MBR Filing to be effective 10/1/2012. Filed Date: 6/5/12. Accession Number: 20120605-5113.... Description: MBR Filing to be effective 10/1/2012. Filed Date: 6/5/12. Accession Number: 20120605-5115.... Description: MBR Filing to be effective 10/1/2012. Filed Date: 6/5/12. Accession Number:...

  3. 76 FR 63291 - Combined Notice Of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-12

    ... II,LLC. submits tariff filing per 35: MBR Tariff to be effective 9/23/2011. Filed Date: 09/23/2011... Electric Development Corp. submits tariff filing per 35: MBR Tariff to be effective 9/23/2011. Filed Date... Eastern Generating Corp. submits tariff filing per 35: MBR Tariff to be effective 9/23/2011. Filed...

  4. 75 FR 12540 - Electronic Tariff Filings; Notice of Technical Conference

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-16

    ... Energy Regulatory Commission Electronic Tariff Filings; Notice of Technical Conference March 9, 2010. As... electronic tariff filing's data elements is the Type of Filing Code. \\1\\ Electronic Tariff Filings, Order No... addressed the tariff filing definitions used for electronic filings and the attachments that are...

  5. Brown Norway rats show impaired nNOS-mediated information transfer in renal autoregulation.

    PubMed

    Wang, Xuemei; Cupples, William A

    2009-01-01

    Nonselective inhibition of NO synthase (NOS) augments myogenic autoregulation of renal blood flow (RBF) and profoundly reduces RBF. Previously in Wistar rats, we showed that augmented autoregulation, but not vasoconstriction, is duplicated by intrarenal inhibition of neuronal NOS (nNOS), whereas intrarenal inhibition of inducible NOS (iNOS) has no effect on RBF or on RBF dynamics. Thus macula densa nNOS transfers information from tubuloglomerular feedback to the afferent arteriole. This information flow requires that macula densa nNOS can sufficiently alter ambient NO concentration, that is, that endothelial NOS (eNOS) and iNOS do not alter local NO concentration. Because the Brown Norway rat often shows exaggerated responses to NOS inhibition and has peculiarities of renal autoregulation that are related to NO, we used this strain to study systemic and renal vascular responses to NOS inhibition. The first experiment showed transient blood pressure reduction by bolus i.v. acetylcholine that was dose-dependent in both strains and substantially prolonged in Brown Norway rats. The depressor response decayed more rapidly after nonselective NOS inhibition and the difference between strains was lost, indicating a greater activity of eNOS in Brown Norway rats. In Brown Norway rats, selective inhibition of iNOS reduced RBF (-16% +/- 7%) and augmented myogenic autoregulation, whereas nNOS inhibition reduced RBF (-25% +/- 4%) and did not augment myogenic autoregulation. The significant responses to intrarenal iNOS inhibition, the reduced modulation of autoregulation by nNOS inhibition, and the enhanced endothelial depressor response suggest that physiological signalling by NO within the kidney is impaired in Brown Norway rats because of irrelevant or inappropriate input of NO by eNOS and iNOS.

  6. OTS: a program for converting Noldus Observer data files to SDIS files.

    PubMed

    Bakeman, R; Quera, V

    2000-02-01

    A program for converting Noldus Observer data files (ODF) to sequential data interchange standard (SDIS) files is described. Observer users who convert their data files can then take advantage of various flexible and powerful data modification and computational procedures available in the Generalized Sequential Querier, a program that assumes SDIS-formatted files.

  7. Exploring Elementary Science Methods Course Contexts to Improve Preservice Teachers' NOS of Science Conceptions and Understandings of NOS Teaching Strategies

    ERIC Educational Resources Information Center

    Akerson, Valarie L.; Weiland, Ingrid; Rogers, Meredith Park; Pongsanon, Khemmawaddee; Bilican, Kader

    2014-01-01

    We explored adaptations to an elementary science methods course to determine how varied contexts could improve elementary preservice teachers' conceptions of NOS as well as their ideas for teaching NOS to elementary students. The contexts were (a) NOS Theme in which the course focused on the teaching of science through the consistent teaching…

  8. 33 CFR 148.246 - When is a document considered filed and where should I file it?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... filed and where should I file it? 148.246 Section 148.246 Navigation and Navigable Waters COAST GUARD... Formal Hearings § 148.246 When is a document considered filed and where should I file it? (a) If a document to be filed is submitted by mail, it is considered filed on the date it is postmarked. If...

  9. 33 CFR 148.246 - When is a document considered filed and where should I file it?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... filed and where should I file it? 148.246 Section 148.246 Navigation and Navigable Waters COAST GUARD... Formal Hearings § 148.246 When is a document considered filed and where should I file it? (a) If a document to be filed is submitted by mail, it is considered filed on the date it is postmarked. If...

  10. 75 FR 39229 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-08

    ..., July 06, 2010. Docket Numbers: RP10-875-000. Applicants: NGO Transmission, Inc. Description: NGO Transmission, Inc. submits tariff filing per 154.203: NGO Transmission--Baseline eTariff Filing to be...

  11. 75 FR 42732 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-22

    ..., July 26, 2010. Docket Numbers: RP10-967-000. Applicants: Garden Banks Gas Pipeline, LLC. Description: Garden Banks Gas Pipeline, LLC submits tariff filing per 154.203: Baseline Filing to be effective...

  12. Explain the CERES file naming convention

    Atmospheric Science Data Center

    2014-12-08

    ... using the dataset name, configuration code and date information which make each file name unique. A Dataset name consists ... 6-digit file and software version management code number - 120145 Date in the form YYYYMMDDHH ...

  13. 78 FR 58533 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-24

    ... received the following Natural Gas Pipeline Rate and Refund Report filings: Filings Instituting Proceedings... Docket Numbers: CP13-548-000 Applicants: Montana-Dakota Utilities Co. Description: Application for...

  14. 12 CFR 303.221 - Filing procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... PROCEDURES Section 19 of the FDI Act (Consent to Service of Persons Convicted of Certain Criminal Offenses) § 303.221 Filing procedures. (a) Where to file. An application under section 19 of the FDI Act shall...

  15. 12 CFR 303.221 - Filing procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... PROCEDURES Section 19 of the FDI Act (Consent to Service of Persons Convicted of Certain Criminal Offenses) § 303.221 Filing procedures. (a) Where to file. An application under section 19 of the FDI Act shall...

  16. 12 CFR 303.221 - Filing procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... PROCEDURES Section 19 of the FDI Act (Consent to Service of Persons Convicted of Certain Criminal Offenses) § 303.221 Filing procedures. (a) Where to file. An application under section 19 of the FDI Act shall...

  17. 12 CFR 303.221 - Filing procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... PROCEDURES Section 19 of the FDI Act (Consent to Service of Persons Convicted of Certain Criminal Offenses) § 303.221 Filing procedures. (a) Where to file. An application under section 19 of the FDI Act shall...

  18. 75 FR 79362 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ...-000. Applicants: Bobcat Gas Storage. Description: Bobcat Gas Storage submits tariff filing per 154.204...-000. Applicants: Bobcat Gas Storage. Description: Bobcat Gas Storage submits tariff filing per...

  19. 75 FR 57754 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-22

    ... 22, 2010. Docket Numbers: RP10-1289-000. Applicants: Bobcat Gas Storage. ] Description: Bobcat Gas Storage submits tariff filing per 154.203: Bobcat Baseline Tariff Filing to be effective 9/10/2010....

  20. 77 FR 14358 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-09

    ...: RP12-469-000. Applicants: Sea Robin Pipeline Company, LLC. Description: Hurricane Surcharge Filing on 3...: RP12-313-001. Applicants: Sea Robin Pipeline Company, LLC. Description: Hurricane Compliance Filing...

  1. 77 FR 60433 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-03

    .... Filing Party: Wayne R. Rohde, Esq.; Cozen O'Connor; 1627 I Street NW., ] Suite 1100; Washington, DC 20006... S.A. Filing Party: Wayne R. Rohde, Esq.; Cozen O'Connor; 1627 I Street NW., Suite 1100;...

  2. 77 FR 63832 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-17

    ... Autoliners AS and Nippon Yusen Kaisha (``NYK''). Filing Party: Wayne R. Rohde, Esq.; Cozen O'Connor; 1627 I...-Lloyd AG. Filing Party: Wayne R. Rohde, Esq.; Cozen O'Connor; 1627 I Street NW., Suite 1100;...

  3. 77 FR 35384 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-13

    ...; and Mediterranean Shipping Company S.A. Filing Party: Wayne R. Rohde, Esq.; Cozen O'Connor; 1627 I.... Ltd. Filing Party: Wayne R. Rohde, Esquire, Cozen O'Connor, 1627 I Street NW., Suite 1100;...

  4. 78 FR 64490 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-29

    ...: Negotiated Rate--Tenaska LPS RO to be effective 10/16/ 2013. Filed Date: 10/16/13. Accession Number: 20131016... Company of America. Description: Tenaska LPS RO Negotiated Rate to be effective 10/16/ 2013. Filed...

  5. 76 FR 12096 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-04

    .... Description: Southern Star Central Gas Pipeline, Inc. submits tariff filing per 154.204: Elk City Tariff Sheet... link to log on and submit the intervention or protests. Persons unable to file electronically...

  6. 75 FR 67356 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-02

    .... Docket Numbers: RP11-1420-000. Applicants: ETC Tiger Pipeline, LLC. Description: ETC Tiger Pipeline, LLC submits tariff filing per 154.203: Tiger NAESB Version 1.9 Compliance Filing to be effective 12/...

  7. 75 FR 66749 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-29

    .... Docket Numbers: RP11-1420-000. Applicants: ETC Tiger Pipeline, LLC. Description: ETC Tiger Pipeline, LLC submits tariff filing per 154.203: Tiger NAESB Version 1.9 Compliance Filing to be effective 12/...

  8. Fail-over file transfer process

    NASA Technical Reports Server (NTRS)

    Semancik, Susan K. (Inventor); Conger, Annette M. (Inventor)

    2005-01-01

    The present invention provides a fail-over file transfer process to handle data file transfer when the transfer is unsuccessful in order to avoid unnecessary network congestion and enhance reliability in an automated data file transfer system. If a file cannot be delivered after attempting to send the file to a receiver up to a preset number of times, and the receiver has indicated the availability of other backup receiving locations, then the file delivery is automatically attempted to one of the backup receiving locations up to the preset number of times. Failure of the file transfer to one of the backup receiving locations results in a failure notification being sent to the receiver, and the receiver may retrieve the file from the location indicated in the failure notification when ready.

  9. 75 FR 61728 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-06

    ...: Negative Rate 2010-09-27 MGE to be effective 11/1/2010. Filed Date: 09/27/2010. Accession Number: 20100927... Commission has received the following Natural Gas Pipeline Rate and Refund Report filings: Docket...

  10. 29 CFR 4062.10 - Method and date of filing; where to file.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Method and date of filing; where to file. 4062.10 Section 4062.10 Labor Regulations Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION LIABILITY LIABILITY FOR TERMINATION OF SINGLE-EMPLOYER PLANS § 4062.10 Method and date of filing; where to file. (a) Method of filing. The PBGC applies...

  11. Oleic acid increases mitochondrial reactive oxygen species production and decreases endothelial nitric oxide synthase activity in cultured endothelial cells.

    PubMed

    Gremmels, Hendrik; Bevers, Lonneke M; Fledderus, Joost O; Braam, Branko; van Zonneveld, Anton Jan; Verhaar, Marianne C; Joles, Jaap A

    2015-03-15

    Elevated plasma levels of free fatty acids (FFA) are associated with increased cardiovascular risk. This may be related to FFA-induced elevation of oxidative stress in endothelial cells. We hypothesized that, in addition to mitochondrial production of reactive oxygen species, endothelial nitric oxide synthase (eNOS)-mediated reactive oxygen species production contributes to oleic acid (OA)-induced oxidative stress in endothelial cells, due to eNOS uncoupling. We measured reactive oxygen species production and eNOS activity in cultured endothelial cells (bEnd.3) in the presence of OA bound to bovine serum albumin, using the CM-H2DCFDA assay and the L-arginine/citrulline conversion assay, respectively. OA induced a concentration-dependent increase in reactive oxygen species production, which was inhibited by the mitochondrial complex II inhibitor thenoyltrifluoroacetone (TTFA). OA had little effect on eNOS activity when stimulated by a calcium-ionophore, but decreased both basal and insulin-induced eNOS activity, which was restored by TTFA. Pretreatment of bEnd.3 cells with tetrahydrobiopterin (BH4) prevented OA-induced reactive oxygen species production and restored inhibition of eNOS activity by OA. Elevation of OA levels leads to both impairment in receptor-mediated stimulation of eNOS and to production of mitochondrial-derived reactive oxygen species and hence endothelial dysfunction.

  12. 76 FR 64935 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-19

    ... Corporation. Description: National Fuel Gas Supply Corporation submits tariff filing per 154.203: Beacon Non.... submits tariff filing per 154.204: DTI--October 11, 2011 Negotiated Rate Agreement to be effective 11/1.... Description: Gas Transmission Northwest LLC submits tariff filing per 154.204: Pressure Commitments to...

  13. 8 CFR 245a.33 - Filing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... NATIONALITY ACT LIFE Act Amendments Family Unity Provisions § 245a.33 Filing. (a) General. An application for Family Unity benefits under section 1504 of the LIFE Act Amendments must be filed on a Form I-817, Application for Family Unity Benefits, with the Missouri Service Center. A Form I-817 must be filed with...

  14. 18 CFR 375.105 - Filings.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Filings. 375.105 Section 375.105 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REVISED GENERAL RULES THE COMMISSION General Provisions § 375.105 Filings. (a) Filings...

  15. 40 CFR 78.4 - Filings.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 17 2013-07-01 2013-07-01 false Filings. 78.4 Section 78.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPEAL PROCEDURES § 78.4 Filings. (a)(1) All original filings made under this part shall be signed by the person...

  16. 78 FR 39723 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-02

    ... invoices for the 2012-2013 heating season. Filed Date: 6/3/13. Accession Number: 20130603-5034. Comments... and Housekeeping Filing to be effective 7/22/2013. Filed Date: 6/20/13. Accession Number: 20130620-5131. Comments Due: 5 p.m. ET 7/2/13. Docket Numbers: RP13-992-000. Applicants: El Paso Natural...

  17. 77 FR 73639 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-11

    ... tariff filing per 154.204: Neg Rate 2012-11-30 WIC, Oxy (Perm Release etc.) to be effective 12/1/2012...: Fayetteville Express Pipeline LLC submits tariff filing per 154.203: FEP 2012 NAESB Filing--Compliance with...

  18. 78 FR 42059 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings Take notice that the Commission has received the.... Description: Net Monthly Imbalance Clarification Compliance Filing to be effective 7/1/2013. Filed Date:...

  19. 18 CFR 154.201 - Filing requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... constitute the filing. Revisions to unmarked portions of the rate schedule or tariff are not considered part of the filing nor will any acceptance of the filing by the Commission constitute acceptance of such... to support the company's proposed change. (1) The documentation must include but is not limited...

  20. 77 FR 70426 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-26

    ... following Natural Gas Pipeline Rate and Refund Report filings: Filings Instituting Proceedings Docket...-000. Applicants: Iroquois Gas Transmission System, L.P. ] Description: 11/15/12 Negotiated Rates--BG...: Iroquois Gas Transmission System, L.P. Description: 11/15/12 HUB Negotiated Rates Blanket Filing 2 to...

  1. 8 CFR 245a.33 - Filing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Filing. 245a.33 Section 245a.33 Aliens and... NATIONALITY ACT LIFE Act Amendments Family Unity Provisions § 245a.33 Filing. (a) General. An application for Family Unity benefits under section 1504 of the LIFE Act Amendments must be filed on a Form...

  2. 77 FR 1064 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-09

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings Take notice that the Commission has received the following Natural Gas Pipeline Rate and Refund Report filings: Filings Instituting Proceedings Docket Numbers: RP12-261-000....

  3. 12 CFR 5.4 - Filing required.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 1 2011-01-01 2011-01-01 false Filing required. 5.4 Section 5.4 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY RULES, POLICIES, AND PROCEDURES FOR... advise an applicant through a pre-filing communication to send the filing or submission directly to...

  4. 76 FR 69271 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-08

    ....); Wan Hai Lines Ltd.; Yang Ming Transport Marine Corp.; and Zim Integrated Shipping Services Ltd. Filing...: Evergreen Line Joint Service Agreement and Mitsui O.S.K. Lines, Ltd. Filing Party: Robert B. Yoshitomi, Esq... Company, Ltd. and Pacific International Lines (PTE) Ltd. Filing Party: Robert B. Yoshitomi, Esq.;...

  5. 77 FR 10489 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-22

    ... of Filing Date for Annual Transportation Costs Rate Adjustment Filing of Columbia Gas Transmission.... Comments Due: 5 p.m. ET 2/27/12. Docket Number: CP09-418-001. Applicants: Perryville Gas Storage LLC. Description: Abbreviated for Amendment of Perryville Gas Storage LLC. Filed Date: 01/26/2012. Accession...

  6. 22 CFR 911.2 - Filing complaint.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Filing complaint. 911.2 Section 911.2 Foreign Relations FOREIGN SERVICE GRIEVANCE BOARD IMPLEMENTATION DISPUTES § 911.2 Filing complaint. If the dispute is not satisfactorily resolved at the agency level, the moving party may file a complaint within...

  7. 22 CFR 911.2 - Filing complaint.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Filing complaint. 911.2 Section 911.2 Foreign Relations FOREIGN SERVICE GRIEVANCE BOARD IMPLEMENTATION DISPUTES § 911.2 Filing complaint. If the dispute is not satisfactorily resolved at the agency level, the moving party may file a complaint within...

  8. 22 CFR 911.2 - Filing complaint.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Filing complaint. 911.2 Section 911.2 Foreign Relations FOREIGN SERVICE GRIEVANCE BOARD IMPLEMENTATION DISPUTES § 911.2 Filing complaint. If the dispute is not satisfactorily resolved at the agency level, the moving party may file a complaint within...

  9. 22 CFR 911.2 - Filing complaint.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Filing complaint. 911.2 Section 911.2 Foreign Relations FOREIGN SERVICE GRIEVANCE BOARD IMPLEMENTATION DISPUTES § 911.2 Filing complaint. If the dispute is not satisfactorily resolved at the agency level, the moving party may file a complaint within...

  10. 22 CFR 911.2 - Filing complaint.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 2 2012-04-01 2009-04-01 true Filing complaint. 911.2 Section 911.2 Foreign Relations FOREIGN SERVICE GRIEVANCE BOARD IMPLEMENTATION DISPUTES § 911.2 Filing complaint. If the dispute is not satisfactorily resolved at the agency level, the moving party may file a complaint within...

  11. 76 FR 19096 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-06

    ...-Maersk A/S and Hapag-Lloyd AG. Filing Party: Wayne Rohde, Esq.; Cozen O'Connor; 1627 I Street, NW.; Suite... Integrated Shipping Services Limited. Filing Party: Wayne Rohde, Esq.; Cozen O'Connor; 1627 I Street, NW... Shipping Services Limited (ZIM). Filing Party: Wayne Rohde, Esq.; Cozen O'Connor; 627 I Street, NW.;...

  12. 77 FR 68121 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-15

    .... Filing Party: Wayne R. Rohde, Esq.; Cozen O'Connor LLP; 1627 I Street NW.; Suite 1100; Washington, DC.../Ro Services, Inc. Filing Party: Wayne R. Rohde, Esq.; Cozen O'Connor; 1627 I Street NW., Suite 1100.... Filing Party: Carlos E. Bayron; Bayron Law Offices, P.S.C.; P.O. Box 6461, Mayaguez, PR 00681....

  13. 8 CFR 245a.33 - Filing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Filing. 245a.33 Section 245a.33 Aliens and... ACT LIFE Act Amendments Family Unity Provisions § 245a.33 Filing. (a) General. An application for Family Unity benefits under section 1504 of the LIFE Act Amendments must be filed on a Form...

  14. 8 CFR 245a.33 - Filing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Filing. 245a.33 Section 245a.33 Aliens and... ACT LIFE Act Amendments Family Unity Provisions § 245a.33 Filing. (a) General. An application for Family Unity benefits under section 1504 of the LIFE Act Amendments must be filed on a Form...

  15. 8 CFR 245a.33 - Filing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Filing. 245a.33 Section 245a.33 Aliens and... ACT LIFE Act Amendments Family Unity Provisions § 245a.33 Filing. (a) General. An application for Family Unity benefits under section 1504 of the LIFE Act Amendments must be filed on a Form...

  16. 78 FR 14779 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-07

    ... calendar year 2012 activity Filed Date: 2/28/13 Accession Number: 20130228-5084 Comments Due: 5 p.m. ET 3... Applicants: Tennessee Gas Pipeline Company, L.L.C. Description: Fuel Tracker 2013 to be effective 4/1/2013... Tracker Filing effective April 1, 2013 to be effective 4/1/2013 Filed Date: 3/1/13 Accession...

  17. 78 FR 76293 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings Take notice that the Commission has received the following Natural Gas Pipeline Rate and Refund Report filings: Filings Instituting Proceedings Docket Numbers: PR14-2-001....

  18. 78 FR 79432 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings Take notice that the Commission has received the following Natural Gas Pipeline Rate and Refund Report filings: Filings Instituting Proceedings Docket Numbers: RP14-293-000....

  19. 78 FR 49494 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-14

    .... Comments Due: 5 p.m. ET 8/12/13. Docket Numbers: RP13-1134-000. Applicants: Panther Interstate Pipeline Energy, LLC. Description: Panther Order No. 776 Compliance Filing to be effective 10/1/2013. Filed Date...-000. Applicants: Florida Gas Transmission Company, LLC. Description: ACA Compliance Filing on...

  20. 78 FR 76291 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-17

    ... following Natural Gas Pipeline Rate and Refund Report filings: Filings Instituting Proceedings Docket... Numbers: RP14-252-000. Applicants: Enable Gas Transmission, LLC. Description: Negotiated Rate Filing...: 20131205-5115. Comments Due: 5 p.m. ET 12/17/13. Docket Numbers: RP14-253-000. Applicants: Algonquin...

  1. 76 FR 62798 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-11

    .... Docket Numbers: RP11-2648-000. Applicants: PetroLogistics Natural Gas Storage, LLC. Description: PetroLogistics Natural Gas Storage, LLC submits tariff filing per 154.204: Revision to Adopt Section for the... following Natural Gas Pipeline Rate and Refund Report filings: Filings Instituting Proceedings...

  2. 76 FR 41778 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-15

    ...: RP11-2258-000. Applicants: PetroLogistics Natural Gas Storage, LLC. Description: PetroLogistics Natural Gas Storage, LLC submits tariff filing per 154.204: Filing of Revised Tariff Records to be effective 8... following Natural Gas Pipeline Rate and Refund Report filings: Docket Numbers: RP11-2256-000....

  3. 47 CFR 1.1405 - File numbers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false File numbers. 1.1405 Section 1.1405... Procedures § 1.1405 File numbers. Each complaint which appears to be essentially complete under § 1.1404 will be accepted and assigned a file number. Such assignment is for administrative purposes only and...

  4. 47 CFR 1.911 - Station files.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Station files. 1.911 Section 1.911... Applications and Proceedings Application Requirements and Procedures § 1.911 Station files. Applications... maintained by the Commission in ULS. These files constitute the official records for these stations...

  5. 21 CFR 211.198 - Complaint files.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Complaint files. 211.198 Section 211.198 Food and... files. (a) Written procedures describing the handling of all written and oral complaints regarding a...) A written record of each complaint shall be maintained in a file designated for drug...

  6. 37 CFR 1.251 - Unlocatable file.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Unlocatable file. 1.251 Section 1.251 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF... § 1.251 Unlocatable file. (a) In the event that the Office cannot locate the file of an...

  7. 47 CFR 76.1701 - Political file.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Political file. 76.1701 Section 76.1701... CABLE TELEVISION SERVICE Documents to be Maintained for Inspection § 76.1701 Political file. (a) Every... (political file) of all requests for cablecast time made by or on behalf of a candidate for public...

  8. 36 CFR 703.20 - File copies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false File copies. 703.20 Section... Is Not a Party § 703.20 File copies. The Office of the General Counsel will maintain the official file of copies of all demands served on the Library and deciding officials' responses....

  9. 21 CFR 225.115 - Complaint files.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Complaint files. 225.115 Section 225.115 Food and... CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Records and Reports § 225.115 Complaint files. (a... feed manufacturer shall maintain on the premises a file which contains the following information:...

  10. 46 CFR 502.161 - Commission's files.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 9 2010-10-01 2010-10-01 false Commission's files. 502.161 Section 502.161 Shipping...; Presiding Officers; Evidence § 502.161 Commission's files. Where any matter contained in a tariff, report, or other document on file with the Commission is offered in evidence, such document need not...

  11. 10 CFR 501.35 - Public file.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Public file. 501.35 Section 501.35 Energy DEPARTMENT OF... Hearings and Conferences During Administrative Proceedings § 501.35 Public file. (a) Contents. The public file shall consist of the rule, order, or petition, with supporting data and supplemental...

  12. 21 CFR 1271.320 - Complaint file.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Complaint file. 1271.320 Section 1271.320 Food and... CELLULAR AND TISSUE-BASED PRODUCTS Current Good Tissue Practice § 1271.320 Complaint file. (a) Procedures... the investigation of complaints as appropriate. (b) Complaint file. You must maintain a record...

  13. 47 CFR 73.1943 - Political file.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Political file. 73.1943 Section 73.1943... Rules Applicable to All Broadcast Stations § 73.1943 Political file. (a) Every licensee shall keep and permit public inspection of a complete and orderly record (political file) of all requests for...

  14. 24 CFR 17.67 - Claims files.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Claims files. 17.67 Section 17.67... files. Each claims collection officer is responsible for obtaining current credit data about each person against whom a claim is pending in his office. The file shall be kept reasonably up to date by...

  15. 77 FR 66973 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-08

    ... following Natural Gas Pipeline Rate and Refund Report filings: Filings Instituting Proceedings Docket.... Docket Numbers: RP13-233-000. Applicants: Natural Gas Pipeline Company of America. Description...: Northern Natural Gas Company. Description: 20121031 Negotiated Rate to be effective 11/1/2012. Filed...

  16. 47 CFR 1.1113 - Filing locations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... the locations and addresses set forth in §§ 1.1102 through 1.1109. (1) Tariff filings shall be filed....1109, as set forth on the bill sent by the Commission. Payments must be accompanied by the bill sent by.... 158(d)(1) or § 1.1116 of this subpart shall file their applications in the appropriate location as...

  17. 78 FR 75554 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings Take notice that the Commission has received the following Natural Gas Pipeline Rate and Refund Report filings: Filings Instituting Proceedings Docket Numbers: RP14-241-000....

  18. 77 FR 73644 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-11

    ... proceeding. Filings in Existing Proceedings Docket Numbers: RP12-1125-001. Applicants: Gulf States Transmission LLC. Description: Gulf States Transmission NAESB 2.0 Compliance with Order Filing to be effective.... Docket Numbers: RP13-364-000. Applicants: Gulf South Pipeline Company, LP. Description: Filing...

  19. 77 FR 1481 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings Take notice that the Commission has received the following Natural Gas Pipeline Rate and Refund Report filings: Filings Instituting Proceedings Docket Numbers: RP12-276-000. Applicants:...

  20. 76 FR 6606 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-07

    ... filing per 154.204: J-W 34689 to Q-West Capacity Release Negative Rate Agreement to be effective 2/1/2011... Negative Rate Agreement to be effective 2/1/2011. Filed Date: 01/28/2011. Accession Number: 20110128-5171... has received the following Natural Gas Pipeline Rate and Refund Report filings: Docket Numbers:...

  1. Evaluated nuclear structure data file

    NASA Astrophysics Data System (ADS)

    Tuli, J. K.

    The Evaluated Nuclear Structure Data File (ENSDF) contains the evaluated nuclear properties of all known nuclides. These properties are derived both from nuclear reaction and radioactive decay measurements. All experimental data are evaluated to create the adopted properties for each nuclide. ENSDF, together with other numeric and biographic files, can be accessed on-line through the INTERNET or modem. Some of the databases are also available on the World Wide Web. The structure and the scope of ENSDF are presented along with the on-line access system of the National Nuclear Data Center at Brookhaven National Laboratory.

  2. Evaluated nuclear structure data file

    NASA Astrophysics Data System (ADS)

    Tuli, J. K.

    1996-02-01

    The Evaluated Nuclear Structure Data File (ENSDF) contains the evaluated nuclear properties of all known nuclides, as derived both from nuclear reaction and radioactive decay measurements. All experimental data are evaluated to create the adopted properties for each nuclide. ENSDF, together with other numeric and bibliographic files, can be accessed on-line through the INTERNET or modem, and some of the databases are also available on the World Wide Web. The structure and the scope of ENSDF are presented along with the on-line access system of the National Nuclear Data Center at Brookhaven National Laboratory.

  3. First light of the NIRISS Optical Simulator (NOS)

    NASA Astrophysics Data System (ADS)

    St-Antoine, Jonathan; Albert, Loïc.; Doyon, René; Vallée, Philippe; Artigau, Étienne; Hernandez, Olivier; Thibault, Simon; Brousseau, Denis

    2016-07-01

    The Near Infrared Imager and Slitless Spectrograph (NIRISS) Optical Simulator (NOS) is a laboratory simulation of the single-object slitless spectroscopy and aperture masking interferometry modes of the NIRISS instrument onboard the James Webb Space Telescope (JWST). A transiting exoplanet can be simulated by periodically eclipsing a small portion (1% - 10ppm) of a super continuum laser source (0.4 μm - 2.4 μm) with a dichloromethane filled cell. Dichloromethane exhibits multiple absorption features in the near infrared domain hence the net effect is analogous to the atmospheric absorption features of an exoplanet transiting in front of its host star. The NOS uses an HAWAII-2RG and an ASIC controller cooled to cryogenic temperatures. A separate photometric beacon provides a flux reference to monitor laser variations. The telescope jitter can be simulated using a high-resolution motorized pinhole placed along the optical path. Laboratory transiting spectroscopy data produced by the NOS will be used to refine analysis methods, characterize the noise due to the jitter, characterize the noise floor and to develop better observation strategies. We report in this paper the first exoplanet transit event simulated by the NOS. The performance is currently limited by relatively high thermal background in the system and high frequency temporal variations of the continuum source.

  4. Las Rocas Nos Cuentan (Rocks Tell Their Stories)

    ERIC Educational Resources Information Center

    Llerandi-Roman, Pablo A.

    2012-01-01

    Many Earth science lessons today still focus on memorizing the names of rocks and minerals. This led the author to develop a lesson that reveals the fascinating stories told by rocks through the study of their physical properties. He first designed the lesson for Puerto Rican teachers, hence its Spanish title: "Las Rocas Nos Cuentan Su Historia."…

  5. 4. Southwest fronts, dock nos. 491 and 492. Southeast end, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Southwest fronts, dock nos. 491 and 492. Southeast end, dock no. 492. View to north. - Offutt Air Force Base, Looking Glass Airborne Command Post, Nose Docks, On either side of Hangar Access Apron at Northwest end of Project Looking Glass Historic District, Bellevue, Sarpy County, NE

  6. Airfield setting of Facility Nos. 175 and 176, taken from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Airfield setting of Facility Nos. 175 and 176, taken from north end of Ford Island Runway, with landplane hangars on the right - U.S. Naval Base, Pearl Harbor, Landplane Hangar Type, Wasp Boulevard and Gambier Bay Street, Pearl City, Honolulu County, HI

  7. Building Nos. 92, 381, and 392, view into common courtyard ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Building Nos. 92, 381, and 392, view into common courtyard between 92 (right), 391 (center deep), and 392 (left), view facing west-northwest - U.S. Naval Base, Pearl Harbor, Marine Railway No. 1 Accessories House & Apprentice Welding School, Additions, Intersection of Avenue B & Sixth Street, Pearl City, Honolulu County, HI

  8. 50. INTERIOR OF BRIDGE SUSPENSION STRUCTURE ABOVE BRIDGE NOS. 10 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    50. INTERIOR OF BRIDGE SUSPENSION STRUCTURE ABOVE BRIDGE NOS. 10 AND 9 SHOWING CABLE COUNTERWEIGHT SYSTEM AND SCREW-TYPE VERTICAL ADJUSTMENT MACHINERY (LIFTING SCREWS). LOOKING NORTH. - Greenville Yard, Transfer Bridge System, Port of New York/New Jersey, Upper New York Bay, Jersey City, Hudson County, NJ

  9. 7. VIEW OF NORTH SECTION OF STRUCTURE SHOWING BRIDGE NOS. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. VIEW OF NORTH SECTION OF STRUCTURE SHOWING BRIDGE NOS. 10 AND 9 FROM BRIDGE NO. 11 APRON. LOOKING NORTH. - Greenville Yard, Transfer Bridge System, Port of New York/New Jersey, Upper New York Bay, Jersey City, Hudson County, NJ

  10. AIRMEN'S BARRACKS (FACILITY Nos. 422, 442, AND 420) IN MIDDLE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    AIRMEN'S BARRACKS (FACILITY Nos. 422, 442, AND 420) IN MIDDLE DISTANCE, ALSO SHOWING ESCOLTA AVENUE AT RIGHT, LOOKING SOUTHEAST FROM RESERVOIR HILL. (Part 2 of a 3 view panorama; see also CA-2398-4 and CA-2398-6.) - Hamilton Field, East of Nave Drive, Novato, Marin County, CA

  11. Overall contextual view of Building Nos. 92, 391, and 392, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Overall contextual view of Building Nos. 92, 391, and 392, taken from pier side, crane rails along bravo piers in foreground, palm tree and street light at right center, view facing east-northeast - U.S. Naval Base, Pearl Harbor, Marine Railway No. 1 Accessories House & Apprentice Welding School, Additions, Intersection of Avenue B & Sixth Street, Pearl City, Honolulu County, HI

  12. Probing the Hydrogen Bonding of the Ferrous–NO Heme Center of nNOS by Pulsed Electron Paramagnetic Resonance

    PubMed Central

    Astashkin, Andrei V.; Chen, Li; Elmore, Bradley O.; Kunwar, Deepak; Miao, Yubin; Li, Huiying; Poulos, Thomas L.; Roman, Linda J.; Feng, Changjian

    2015-01-01

    Oxidation of L-arginine (L-Arg) to nitric oxide (NO) by NO synthase (NOS) takes place at the heme active site. It is of current interest to study structures of the heme species that activates O2 and transforms the substrate. The NOS ferrous–NO complex is a close mimic of the obligatory ferric (hydro)peroxo intermediate in NOS catalysis. In this work, pulsed electron–nuclear double resonance (ENDOR) spectroscopy was used to probe the hydrogen bonding of the NO ligand in the ferrous–NO heme center of neuronal NOS (nNOS) without a substrate and with L-Arg or N-hydroxy-L-arginine (NOHA) substrates. Unexpectedly, no H-bonding interaction connecting the NO ligand to the active site water molecule or the Arg substrate was detected, in contrast to the results obtained by X-ray crystallography for the Arg-bound nNOS heme domain [Li et al. J. Biol. Inorg. Chem. 2006, 11, 753–768]. The nearby exchangeable proton in both the no-substrate and Arg-containing nNOS samples is located outside the H-bonding range and, on the basis of the obtained structural constraints, can belong to the active site water (or OH). On the contrary, in the NOHA-bound sample, the nearby exchangeable hydrogen forms an H-bond with the NO ligand (on the basis of its distance from the NO ligand and a nonzero isotropic hfi constant), but it does not belong to the active site water molecule because the water oxygen atom (detected by 17O ENDOR) is too far. This hydrogen should therefore come from the NOHA substrate, which is in agreement with the X-ray crystallography work [Li et al. Biochemistry 2009, 48, 10246–10254]. The nearby nonexchangeable hydrogen atom assigned as Hɛ of Phe584 was detected in all three samples. This hydrogen atom may have a stabilizing effect on the NO ligand and probably determines its position. PMID:26035438

  13. Characterization of the Proximal Ligand in the P420 Form of iNOS

    PubMed Central

    Sabat, Joseph; Stuehr, Dennis J.; Yeh, Syun-Ru; Rousseau, Denis L.

    2010-01-01

    The nitric oxide (NO) produced by inducible Nitric Oxide Synthase (iNOS) up-regulates the expression of heme oxygenase (HO), which in turn produces carbon monoxide (CO) that down-regulates iNOS activity by reducing its expression level or by inhibiting its activity by converting it to an inactive P420 form (iNOSP420). Accordingly, CO has been considered as a potentially important attenuator of inflammation. Despite its importance, the nature of the proximal heme ligand of the iNOSP420 species remains elusive. Here we show that the 221 cm−1 mode of the photoproduct of iNOSP420 does not exhibit any H2O-D2O solvent isotope shift such as that found in the iron-histidine stretching mode of myoglobin, indicating that the proximal ligand of iNOSP420 is not a histidine. The νFe-CO and νC-O data reveal that the proximal heme ligand of iNOSP420 is consistent with a protonated thiol, instead of a thiolate anion. Furthermore, the optical absorption properties of iNOSP420 are similar to those of a neutral thiol-heme model complex, but not myoglobin. Together the data support the scenario that iNOSP420 is inactivated by protonation of the native proximal thiolate ligand to a neutral thiol, instead of by ligand switching to a histidine, as prior studies have suggested. PMID:19658411

  14. A Glimpse at Different File Formats

    NASA Astrophysics Data System (ADS)

    Shortridge, K.

    2015-09-01

    The image display program AAOGlimpse has recently been extended to provide support for files using both HDF5 and NDF/HDS formats. Loosely defined formats present problems. Given an input file, what should be displayed? A FITS file may contain multiple images, and for the more flexible hierarchical formats things are even less clear: which of the many arrays in a structure actually represents the data of interest? Where is the wavelength or other WCS data? With HDF5 files, this becomes quite complex. This paper describes the way AAOGlimpse handles these questions, and emphasises the importance of agreeing conventions for how file formats are used.

  15. File concepts for parallel I/O

    NASA Technical Reports Server (NTRS)

    Crockett, Thomas W.

    1989-01-01

    The subject of input/output (I/O) was often neglected in the design of parallel computer systems, although for many problems I/O rates will limit the speedup attainable. The I/O problem is addressed by considering the role of files in parallel systems. The notion of parallel files is introduced. Parallel files provide for concurrent access by multiple processes, and utilize parallelism in the I/O system to improve performance. Parallel files can also be used conventionally by sequential programs. A set of standard parallel file organizations is proposed, organizations are suggested, using multiple storage devices. Problem areas are also identified and discussed.

  16. Sildenafil Ameliorates Gentamicin-Induced Nephrotoxicity in Rats: Role of iNOS and eNOS

    PubMed Central

    Morsy, Mohamed A.; Ibrahim, Salwa A.; Amin, Entesar F.; Kamel, Maha Y.; Rifaai, Rehab A.; Hassan, Magdy K.

    2014-01-01

    Gentamicin, an aminoglycoside antibiotic, is used for the treatment of serious Gram-negative infections. However, its usefulness is limited by its nephrotoxicity. Sildenafil, a selective phosphodiesterase-5 inhibitor, was reported to prevent or decrease tissue injury. The aim of this study is to evaluate the potential protective effects of sildenafil on gentamicin-induced nephrotoxicity in rats. Male Wistar rats were injected with gentamicin (100 mg/kg/day, i.p.) for 6 days with and without sildenafil. Sildenafil administration resulted in nephroprotective effect in gentamicin-intoxicated rats as it significantly decreased serum creatinine and urea, urinary albumin, and renal malondialdehyde and nitrite/nitrate levels, with a concomitant increase in renal catalase and superoxide dismutase activities compared to gentamicin-treated rats. Moreover, immunohistochemical examination revealed that sildenafil treatment markedly reduced inducible nitric oxide synthase (iNOS) expression, while expression of endothelial nitric oxide synthase (eNOS) was markedly enhanced. The protective effects of sildenafil were verified histopathologically. In conclusion, sildenafil protects rats against gentamicin-induced nephrotoxicity possibly, in part, through its antioxidant activity, inhibition of iNOS expression, and induction of eNOS production. PMID:25120567

  17. A Metadata-Rich File System

    SciTech Connect

    Ames, S; Gokhale, M B; Maltzahn, C

    2009-01-07

    Despite continual improvements in the performance and reliability of large scale file systems, the management of file system metadata has changed little in the past decade. The mismatch between the size and complexity of large scale data stores and their ability to organize and query their metadata has led to a de facto standard in which raw data is stored in traditional file systems, while related, application-specific metadata is stored in relational databases. This separation of data and metadata requires considerable effort to maintain consistency and can result in complex, slow, and inflexible system operation. To address these problems, we have developed the Quasar File System (QFS), a metadata-rich file system in which files, metadata, and file relationships are all first class objects. In contrast to hierarchical file systems and relational databases, QFS defines a graph data model composed of files and their relationships. QFS includes Quasar, an XPATH-extended query language for searching the file system. Results from our QFS prototype show the effectiveness of this approach. Compared to the defacto standard, the QFS prototype shows superior ingest performance and comparable query performance on user metadata-intensive operations and superior performance on normal file metadata operations.

  18. Deceit: A flexible distributed file system

    NASA Technical Reports Server (NTRS)

    Siegel, Alex; Birman, Kenneth; Marzullo, Keith

    1989-01-01

    Deceit, a distributed file system (DFS) being developed at Cornell, focuses on flexible file semantics in relation to efficiency, scalability, and reliability. Deceit servers are interchangeable and collectively provide the illusion of a single, large server machine to any clients of the Deceit service. Non-volatile replicas of each file are stored on a subset of the file servers. The user is able to set parameters on a file to achieve different levels of availability, performance, and one-copy serializability. Deceit also supports a file version control mechanism. In contrast with many recent DFS efforts, Deceit can behave like a plain Sun Network File System (NFS) server and can be used by any NFS client without modifying any client software. The current Deceit prototype uses the ISIS Distributed Programming Environment for all communication and process group management, an approach that reduces system complexity and increases system robustness.

  19. CALCEPH: Planetary ephemeris files access code

    NASA Astrophysics Data System (ADS)

    Gastineau, M.; Laskar, J.; Manche, H.; Fienga, A.

    2015-05-01

    CALCEPH accesses binary planetary ephemeris files, including INPOPxx, JPL DExxx ,and SPICE ephemeris files. It provides a C Application Programming Interface (API) and, optionally, a Fortran 77 or 2003 interface to be called by the application. Two groups of functions enable the access to the ephemeris files, single file access functions, provided to make transition easier from the JPL functions, such as PLEPH, to this library, and many ephemeris file at the same time. Although computers have different endianess (order in which integers are stored as bytes in computer memory), CALCEPH can handles the binary ephemeris files with any endianess by automatically swaps the bytes when it performs read operations on the ephemeris file.

  20. Gender Issues: An Activity File.

    ERIC Educational Resources Information Center

    Fountain, Susan

    This activity file grew out of research of an "Images of Women in Development" project of the Centre for Global Education at the University of York, England. The activities are intended for students in the 8- to 13-year-old range to learn more about gender issues. The activities are divided into four sections: (1) awareness-raising activities in…

  1. Single file diffusion in microtubules

    NASA Astrophysics Data System (ADS)

    Rutenberg, Andrew; Farrell, Spencer; Brown, Aidan

    2015-03-01

    We investigate the single file diffusion (SFD) of large particles entering a confined tubular geometry, such as luminal diffusion of proteins inside microtubules or flagella. While single-file effects have no effect on particle density, we report significant single-file effects for individually-tracked tracer particle motion. Both exact and approximate ordering statistics of particles entering semi-infinite tubes agree well with our stochastic simulations. Considering initially empty semi-infinite tubes, with particles entering at one end starting from an initial time t = 0 , tracked particles display super-diffusive effective exponents just after they enter the system and trends towards diffusive exponents at later times. Equivalently, if diffusive exponents are assumed the effective diffusivity is reduced at early times and enhanced at later times through a logarithmic factor logN , where N is the number of particles in the tube. When we number each particle from the first (n = 1) to the most recent (n = N), we find good scaling collapse of the effective diffusivity for all n. Techniques that track individual particles, or local groups of particles, such as photo-activation or photobleaching, will exhibit single-file effects.

  2. Registering Researchers in Authority Files

    ERIC Educational Resources Information Center

    Smith-Yoshimura, Karen; Altman, Micah; Conlon, Michael; Cristán, Ana Lupe; Dawson, Laura; Dunham, Joanne; Hickey, Thom; Hook, Daniel; Horstmann, Wolfram; MacEwan, Andrew; Schreur, Philip; Smart, Laura; Wacker, Melanie; Woutersen, Saskia

    2014-01-01

    Written by OCLC Research Program Officer Karen Smith-Yoshimura and the 13 members of the Registering Researchers in Authority Files Task Group comprised of specialists from the US, UK, and the Netherlands, this report summarizes their research into approaches to providing authoritative researcher identifiers. Registering researchers in some type…

  3. Open File: Education in Asia.

    ERIC Educational Resources Information Center

    Ordonez, Victor, Ed.; Maclean, Rupert, Ed.

    2000-01-01

    This collection of scholarly essays on comparative education is divided into four sections. The first section, Viewpoints/Controversies, contains the essay "Educational Policies and Contents in Developing Countries" (Jacques Hallak). The second section, Open File: Education in Asia, contains the following essays: "Some Current…

  4. Exendin-4 protects endothelial cells from lipoapoptosis by PKA, PI3K, eNOS, p38 MAPK, and JNK pathways.

    PubMed

    Erdogdu, Ozlem; Eriksson, Linnéa; Xu, Hua; Sjöholm, Ake; Zhang, Qimin; Nyström, Thomas

    2013-04-01

    Experimental studies have indicated that endothelial cells play an important role in maintaining vascular homeostasis. We previously reported that human coronary artery endothelial cells (HCAECs) express the glucagon-like peptide 1 (GLP1) receptor and that the stable GLP1 mimetic exendin-4 is able to activate the receptor, leading to increased cell proliferation. Here, we have studied the effect of exendin-4 and native GLP1 (7-36) on lipoapoptosis and its underlying mechanisms in HCAECs. Apoptosis was assessed by DNA fragmentation and caspase-3 activation, after incubating cells with palmitate. Nitric oxide (NO) and reactive oxidative species (ROS) were analyzed. GLP1 receptor activation, PKA-, PI3K/Akt-, eNOS-, p38 MAPK-, and JNK-dependent pathways, and genetic silencing of transfection of eNOS were also studied. Palmitate-induced apoptosis stimulated cells to release NO and ROS, concomitant with upregulation of eNOS, which required activation of p38 MAPK and JNK. Exendin-4 restored the imbalance between NO and ROS production in which ROS production decreased and NO production was further augmented. Incubation with exendin-4 and GLP1 (7-36) protected HCAECs against lipoapoptosis, an effect that was blocked by PKA, PI3K/Akt, eNOS, p38 MAPK, and JNK inhibitors. Genetic silencing of eNOS also abolished the anti-apoptotic effect afforded by exendin-4. Our results support the notion that GLP1 receptor agonists restore eNOS-induced ROS production due to lipotoxicity and that such agonists protect against lipoapoptosis through PKA-PI3K/Akt-eNOS-p38 MAPK-JNK-dependent pathways via a GLP1 receptor-dependent mechanism.

  5. Association of NOS2 and NOS3 gene polymorphisms with susceptibility to type 2 diabetes mellitus and diabetic nephropathy in the Chinese Han population.

    PubMed

    Chen, Feng; Li, Yu-Mei; Yang, Lin-Qing; Zhong, Cai-Gao; Zhuang, Zhi-Xiong

    2016-07-01

    Inducible nitric oxide synthase (NOS2) and endothelial nitric oxide synthase (NOS3) gene play important roles in the susceptibility to type 2 diabetes mellitus (T2DM). The present study aims to detect the potential association of NOS2 and NOS3 gene polymorphisms with the susceptibility toT2DM and diabetic nephropathy (DN) in the Chinese Han population. Four hundred and ninety T2DM patients and 485 healthy controls were enrolled in this case-control study. The genotypes of NOS2 and NOS3 gene polymorphisms were analyzed by the polymerase chain reaction (PCR)-ligase detection reaction (LDR) method. Our data demonstrated that the NOS2 rs2779248 and NOS2 rs1137933 genetic polymorphisms were significantly associated with the increased susceptibility to T2DM in the heterozygote comparison, dominant model, and allele contrast; and NOS3 rs3918188 genetic polymorphism was significantly associated with the increased susceptibility to T2DM in the homozygote comparison and recessive model. The allele-C and genotype-TC of NOS2 rs2779248, allele-A and genotype-GA of NOS2 rs1137933 and genotype-AA of NOS3 rs3918188 genetic polymorphisms might be the risk factors for increasing the susceptibility to T2DM. And a significant haplotype effect of NOS2 rs10459953/C- rs1137933/G- rs2779248/T was found between T2DM cases and controls. Moreover, NOS3 rs1800783 polymorphism was significantly associated with the increased susceptibility to DN in the heterozygote comparison, recessive model and allele contrast. At last, a positive correlation of family history of diabetes with NOS3 rs11771443 polymorphism was found in DN. These preliminary findings indicate that the NOS2 rs2779248, NOS2 rs1137933, and NOS3 rs3918188 genetic polymorphisms are potentially related to the susceptibility to T2DM, and the rs1800783 polymorphism might be considered as genetic risk factors for diabetic nephropathy, and family history of diabetes was closely associated with rs11771443 polymorphism in DN, and the

  6. Endothelial nitric oxide synthase: From biochemistry and gene structure to clinical implications of NOS3 polymorphisms.

    PubMed

    Oliveira-Paula, Gustavo H; Lacchini, Riccardo; Tanus-Santos, Jose E

    2016-01-10

    Nitric oxide (NO) is an important vasodilator with a well-established role in cardiovascular homeostasis. While mediator is synthesized from L-arginine by neuronal, endothelial, and inducible nitric oxide synthases (NOS1,NOS3 and NOS2 respectively), NOS3 is the most important isoform for NO formation in the cardiovascular system. NOS3 is a dimeric enzyme whose expression and activity are regulated at transcriptional, posttranscriptional,and posttranslational levels. The NOS3 gene, which encodes NOS3, exhibits a number of polymorphic sites including single nucleotide polymorphisms (SNPs), variable number of tandem repeats (VNTRs), microsatellites, and insertions/deletions. Some NOS3 polymorphisms show functional effects on NOS3 expression or activity, thereby affecting NO formation. Interestingly, many studies have evaluated the effects of functional NOS3 polymorphisms on disease susceptibility and drug responses. Moreover, some studies have investigated how NOS3 haplotypes may impact endogenous NO formation and disease susceptibility. In this article,we carried out a comprehensive review to provide a basic understanding of biochemical mechanisms involved in NOS3 regulation and how genetic variations in NOS3 may translate into relevant clinical and pharmacogenetic implications.

  7. 21 CFR 516.163 - Change in ownership of an index file.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 6 2013-04-01 2013-04-01 false Change in ownership of an index file. 516.163 Section 516.163 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS NEW ANIMAL DRUGS FOR MINOR USE AND MINOR SPECIES...

  8. Small file aggregation in a parallel computing system

    DOEpatents

    Faibish, Sorin; Bent, John M.; Tzelnic, Percy; Grider, Gary; Zhang, Jingwang

    2014-09-02

    Techniques are provided for small file aggregation in a parallel computing system. An exemplary method for storing a plurality of files generated by a plurality of processes in a parallel computing system comprises aggregating the plurality of files into a single aggregated file; and generating metadata for the single aggregated file. The metadata comprises an offset and a length of each of the plurality of files in the single aggregated file. The metadata can be used to unpack one or more of the files from the single aggregated file.

  9. 12 CFR 908.25 - Filing of papers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Filing of papers. 908.25 Section 908.25 Banks... RULES OF PRACTICE AND PROCEDURE IN HEARINGS ON THE RECORD General Rules § 908.25 Filing of papers. (a) Filing. Any papers required to be filed shall be addressed to the presiding officer and filed with...

  10. 76 FR 19339 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-07

    ... ICAP Demand Curve Filing to be effective N/A. Filed Date: 03/30/2011. Accession Number: 20110330-5026... filing per 35: Compliance Filing--ICAP Demand Curve Tariff Revisions to be effective 12/31/9998. Filed... and 214 of the Commission's Rules of Practice and Procedure (18 CFR 385.211 and 385.214) on or...

  11. 12 CFR 908.25 - Filing of papers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Filing of papers. 908.25 Section 908.25 Banks... RULES OF PRACTICE AND PROCEDURE IN HEARINGS ON THE RECORD General Rules § 908.25 Filing of papers. (a) Filing. Any papers required to be filed shall be addressed to the presiding officer and filed with...

  12. 77 FR 34943 - Combined Notice of Filings #2

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-12

    ... Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the... Texas North Company. Description: AEP Texas North Company submits tariff filing per 35.13(a)(2)(iii: TNC..., LLC submits tariff filing per 35.13(a)(2)(iii: Reactive Filing to be effective 12/31/9998. Filed...

  13. 76 FR 47569 - Combined Notice of Filings #2

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-05

    ... Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the....13(a)(2)(iii: Aug 2011 Membership Filing to be effective 8/1/2011. Filed Date: 08/01/2011. Accession... submits tariff filing per 35.13(a)(2)(iii: CCSF IA--34th Quarterly Filing of Facilities Agreements to...

  14. 75 FR 53289 - Combined Notice of Filings No. 1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-31

    ... Electric Corporation submits tariff filing per 35.12: RG&E MBR Baseline eTariff Filing to be effective 8....P. submits tariff filing per 35.12: Covanta Delaware Valley MBR Baseline eTariff Filing to be.... Description: Covanta Essex Company submits tariff filing per 35.12: Covanta Essex MBR Baseline eTariff...

  15. 75 FR 66075 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-27

    ... Company. Description: Columbus Southern Power Company submits tariff filing per 35.12: Baseline MBR... tariff filing per 35.12: Baseline MBR Concurrence to be effective 10/8/2010. Filed Date: 10/19/2010... tariff filing per 35.12: Baseline MBR Concurrence to be effective 10/8/2010. Filed Date:...

  16. 75 FR 54612 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-08

    ... tariff filing per 35.12: San Joaquin Cogen, LLC MBR Tariff to be effective 8/25/2010. Filed Date: 08/25... (California) Malburg LLC submits tariff filing per 35.12: Bicent (California) Malburg MBR Tariff to be... tariff filing per 35.12: BIV Generation Company, LLC MBR Tariff to be effective 8/25/ 2010. Filed...

  17. 78 FR 21926 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-12

    ...: Bluesource Energy LLC. Description: Amendment to Initial MBR filing to be effective 4/5/ 2013. Filed Date: 4.... Description: Revised MBR Filing to be effective 12/31/9998. Filed Date: 4/4/13. Accession Number: 20130404.... Applicants: Patua Project LLC. Description: Patua Project LLC MBR Tariff to be effective 6/1/2013. Filed...

  18. 29 CFR 1978.102 - Filing of discrimination complaint.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... or other adverse action; or where the discrimination is in the nature of a continuing violation. The... 29 Labor 9 2010-07-01 2010-07-01 false Filing of discrimination complaint. 1978.102 Section 1978... § 1978.102 Filing of discrimination complaint. (a) Who may file. An employee may file, or have filed...

  19. 12 CFR 1081.111 - Filing of papers.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 8 2012-01-01 2012-01-01 false Filing of papers. 1081.111 Section 1081.111... General Rules § 1081.111 Filing of papers. (a) Filing. The following papers must be filed by parties in an... reconsideration. The hearing officer shall file all written orders, rulings, notices, or requests. Any...

  20. 12 CFR 1081.111 - Filing of papers.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 8 2013-01-01 2013-01-01 false Filing of papers. 1081.111 Section 1081.111... General Rules § 1081.111 Filing of papers. (a) Filing. The following papers must be filed by parties in an... reconsideration. The hearing officer shall file all written orders, rulings, notices, or requests. Any...

  1. 12 CFR 1081.111 - Filing of papers.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 9 2014-01-01 2014-01-01 false Filing of papers. 1081.111 Section 1081.111... General Rules § 1081.111 Filing of papers. (a) Filing. The following papers must be filed by parties in an... reconsideration. The hearing officer shall file all written orders, rulings, notices, or requests. Any...

  2. 47 CFR 61.14 - Method of filing publications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 3 2012-10-01 2012-10-01 false Method of filing publications. 61.14 Section 61...) TARIFFS Rules for Electronic Filing § 61.14 Method of filing publications. (a) Publications filed... date of a publication received by the Electronic Tariff Filing System will be determined by the...

  3. 47 CFR 61.14 - Method of filing publications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Method of filing publications. 61.14 Section 61...) TARIFFS Rules for Electronic Filing § 61.14 Method of filing publications. (a) Publications filed... date of a publication received by the Electronic Tariff Filing System will be determined by the...

  4. 47 CFR 61.14 - Method of filing publications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 3 2014-10-01 2014-10-01 false Method of filing publications. 61.14 Section 61...) TARIFFS Rules for Electronic Filing § 61.14 Method of filing publications. (a) Publications filed... date of a publication received by the Electronic Tariff Filing System will be determined by the...

  5. 46 CFR 531.5 - Duty to file.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 9 2010-10-01 2010-10-01 false Duty to file. 531.5 Section 531.5 Shipping FEDERAL... General Provisions § 531.5 Duty to file. (a) The duty under this part to file NSAs, amendments and notices.... (d) Registration—(1) Application. Authority to file or delegate the authority to file must...

  6. 32 CFR 727.14 - Files and records.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Files and records. 727.14 Section 727.14....14 Files and records. (a) Case files. The material contained in legal assistance case files is... attorney-client relationship. Each legal assistance office should therefore maintain only such files as...

  7. 76 FR 78630 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-19

    .... Description: Compliance Filing ER11-4158 to be effective 9/27/2011. Filed Date: 12/9/11. Accession Number..., LLC. Description: ER11-4416 Compliance Filing to be effective 11/1/2011. Filed Date: 12/9/11...: DB Energy Trading LLC. Description: December 9, 2011 Amendment Filing to be effective 11/...

  8. 77 FR 14512 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-12

    ...-458-004. Applicants: Quantum Choctaw Power, LLC. Description: Quantum Choctaw Power Compliance Filing... become a party to the proceeding. eFiling is encouraged. More detailed information relating to filing....ferc.gov/docs-filing/efiling/filing-req.pdf . For other information, call (866) 208-3676 (toll...

  9. 1. Streetscape of north ends of Detention Wards, Building Nos. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Streetscape of north ends of Detention Wards, Building Nos. 9946-B (left) and 9945-B (middle). Walled-in courtyard adjoins Building No. 9944-B at extreme right edge. Steam plant is in distance. This photo makes a panorama with photo WA-202-10-2. - Madigan Hospital, Detention Wards, Bounded by Wilson & McKinley Avenues & Garfield & Lincoln Streets, Tacoma, Pierce County, WA

  10. 38. View of DRS 1, 2, and 3 (structure nos. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    38. View of DRS 1, 2, and 3 (structure nos. 735, 736, and 737) console fault locator for beam power status, radio frequency (RF) and intermediate frequency (IF) fault conditions, RF switches status and TR status. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  11. 78 FR 78437 - Self-Regulatory Organizations; BOX Options Exchange LLC; Notice of Filing of Amendment Nos. 1 and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-26

    ... Complex Order or BOX Book Interest is equal to or better than the cNBBO on the opposite side of the COPIP... the Complex Order Book or cBBO is equal to or better than the cNBBO, on the opposite side of the...\\ In cases where an Unrelated Order that is a BOX Book Interest exists on the opposite side of...

  12. 76 FR 51980 - Atlantic Shipping Company, Inc. v. Di Nos Shipping, Inc.; Notice of Filing of Complaint and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-19

    ... forwarder without a license and that Respondent has copied Complainant's standard contract, known as a dock... form of dock receipt and bill of lading.'' The full text of the complaint can be found in the... testimony and cross-examination in the discretion of the presiding officer only upon proper showing...

  13. 78 FR 4494 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing of Amendment Nos. 2 and 3...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-22

    ... role in assuring that companies listed for trading on the exchanges' markets observe good governance..., ``Corporate Governance Requirements.'' Specifically, BATS proposes to amend BATS Rule 14.10(c)(4... Certain Corporate Governance Requirements.'' 1. Compensation Committee Composition and...

  14. 75 FR 41264 - Self-Regulatory Organizations; NYSE Amex LLC; Notice of Filing of Amendment Nos. 2 and 3, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-15

    ... Committee,'' consisting of NYSE Euronext employees of the Operations and U.S. Markets Divisions,\\5\\ which.... Q. Limitation of Liability The Exchange will be relying on data feeds from the UTP Listing Market... impediments to and perfect the mechanism of a free and open market and a national market system and,...

  15. 75 FR 3263 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing of Amendment Nos. 2...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-20

    ... Letter''); John Jacobs, Director of Operations, Lime Brokerage LLC, dated February 17, 2009 (``Lime I...''); Jeff Bell, Executive Vice President, Clearing and Technology Group, Wedbush Morgan Securities, dated... Jacobs, Chief Operations Officer, Lime Brokerage LLC, dated June 30, 2009 (``Lime II Letter'');...

  16. 78 FR 4554 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing of Amendment Nos. 1...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-22

    ... company must continue to comply with the corresponding provisions, if any, in the current rules, see infra... explicitly in its rules, are specified in the text accompanying note 55, infra. \\18\\ Other provisions in Rule... this provision, a listed company must certify that it has adopted such a charter and that...

  17. Hydrogen species

    NASA Technical Reports Server (NTRS)

    Schiff, H. I.; Burnett, C.; Carli, B.; Dezafra, R.; Evans, W. F. J.; Guthrie, P. D.; Hampson, R. F.; Heaps, W.; Jones, R.; Kley, D.

    1985-01-01

    Measurements of the members of the HO(x) family (OH, HO2, and H2O2) and their major source gases, H2O, and CH4 are discussed. Emphasis is placed on measurements which were made since the 1982 World Meteorologic Organization (WMO) report. Measurement techniques, available data, an assessment of data reliability, and a comparison of the data with theoretical distributions of stratospheric HO(x) species predicted from one and two dimensional photochemical models are discussed.

  18. TNFα antagonization alters NOS2 dependent nasopharyngeal carcinoma tumor growth.

    PubMed

    Bourouba, Mehdi; Zergoun, Ahmed-Amine; Maffei, Joseph S; Chila, Dalia; Djennaoui, Djamel; Asselah, Fatima; Amir-Tidadini, Zine-Charef; Touil-Boukoffa, Chafia; Zaman, Muhammad H

    2015-07-01

    Tumor necrosis factor (TNFα) is a pro-inflammatory cytokine which mediates via nitric oxide (NO) several carcinogenic processes. Increasing evidences suggest that NO promotes inflammation induced growth of nasopharyngeal carcinoma (NPC). In patients, TNFα synthesis associates with poor survival. To explore the effect of the cytokine on NO production and NOS2 dependent NPC growth, NO2(-) (nitrite) producing cells in patients were analyzed in vitro. We observed that patients' monocytes/macrophages (Mo/Ma) and primary tumor biopsies synthesized significant amounts of NO2(-). Interestingly, tumor explants derived NO2(-) levels were more important in elderly patients in comparison with juveniles. Endogenous TNFα neutralization with an anti-TNFα monoclonal antibody (mAb) successfully inhibited NO2(-) synthesis by blood mononuclear cells and tumor explants. Recombinant TNFα (rTNFα) enhanced NO2(-) synthesis and C666-1 NPC cell proliferation. NOS2 selective inhibition (1400W) and TNFα antagonization with an anti-TNFα mAb potently inhibited rTNFα induced C666-1 proliferation and NO2(-) production. Importantly, primary tumors treated with the anti-TNFα mAb also displayed reduced proliferation index (Ki67). Altogether, our results define monocytes/macrophages and the primary tumor as major sources of circulating NO2(-) in NPC patients and support the idea that antibody dependent inhibition of the TNFα/NOS2 pathway may alter NPC tumor growth.

  19. Converting Spreadsheet Files into Data Base Files Using AppleWorks V2.0 and the Apple IIGS Computer.

    ERIC Educational Resources Information Center

    Schlenker, Richard M.

    This guide was developed as a "how to" training device for converting spreadsheet files into database files using AppleWorks version 2.0 on the Apple IIGS computer with two disk drives. Step-by-step instructions are provided for loading spreadsheet files, transferring spreadsheet files to the monitor, printing spreadsheet files, and…

  20. 14 CFR 221.201 - Statement of filing with foreign governments to be shown in air carrier's tariff filings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... governments to be shown in air carrier's tariff filings. 221.201 Section 221.201 Aeronautics and Space OFFICE... Electronically Filed Tariffs § 221.201 Statement of filing with foreign governments to be shown in air carrier's tariff filings. (a) Every electronic tariff filed by or on behalf of an air carrier that contains...