Science.gov

Sample records for species file nos

  1. 78 FR 32622 - Endangered Species; File Nos. 17557 and 17273

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ... National Ocean Service Marine Forensic Lab (NOS Lab) , 219 Fort Johnson Road, Charleston, SC 29412 (File No... to take marine mammal and endangered species parts for purposes of scientific research. DATES... taking, importing, and exporting of endangered and threatened species (50 CFR parts 222-226). The NOS...

  2. 76 FR 15300 - Endangered Species; File Nos. 16266 and 16291

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-21

    ... National Oceanic and Atmospheric Administration RIN 0648-XA306 Endangered Species; File Nos. 16266 and 16291 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration... educating the public on shortnose sturgeon life history and the reasons for the species decline....

  3. 77 FR 21750 - Endangered Species; File Nos. 16549 and 17095

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-11

    ... under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.) and... regions and depth strata. Researchers would non-lethally capture, handle, measure, weigh, scan for...

  4. 77 FR 1061 - Endangered Species; File Nos. 16229 and 16548

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-09

    ... the Federal Register (76 FR 51945 and 76 FR 40699) that requests for enhancement permits to take... Zoo, 4401 Zoo ] Parkway, Asheboro, NC 27203 , and the Springfield Science Museum, 21 Edwards Street... species (50 CFR parts 222-226). The North Carolina Zoo and the Springfield Science Museum have been...

  5. 76 FR 37065 - Endangered Species; File Nos. 16266 and 16291

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-24

    ... was published in the Federal Register (76 FR 15300) that a request for enhancement permits to take... Aquarium at Norwalk, 10 North Water Street, South Norwalk, CT 06854 have been issued permits to take... species (50 CFR Parts 222-226). The Virginia Living Museum and the Maritime Aquarium at Norwalk have...

  6. 77 FR 21754 - Endangered Species; File Nos. 16526, 16323, 16436, 16422, 16438, 16431, 16507, 16547, 16375...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-11

    ... 21, 2011, notice was published in the Federal Register (76 FR 58469) that 12 requests for scientific... the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.) and the... will be captured using a combination of side-scan sonar and gill nets. Captured individuals will...

  7. [János Bolyai's health according to his military files].

    PubMed

    Acs, Tibor

    2002-01-01

    nos Bolyai (1802-1860) one of the greatest mathematicians of the 19th century, the founder and inventor of non-Euclidean geometry, was born in Transylvania, as son of a Hungarian nobleman and scientist, Farkas Bolyai. Having finished his studies at the Academy for Engineering Corps in Vienna, he joined the army. From 1823 to 1833 he served at different places all over the the Empire. Being however physically and mentally unbalanced, he underwent several medical examinations during his military service. Based on archival documents and files of medical examinations and on those of the following resolutions, the author of the present article gives a comprehensive and very detailed account of the young genius's military career and on the circumstances determining his mental activities while creating the most admirable mathematical theory of the age.

  8. 75 FR 37389 - Marine Mammals; File Nos. 14628 and 15471

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-29

    ...), PO Box 37012, Washington, DC 20013 (File No. 14628) andMichael Adkesson, D.V.M., Chicago Zoological... requested. File No. 15471: Michael Adkesson, D.V.M. is requesting authorization to import biological...

  9. 75 FR 42689 - Marine Mammals; File Nos. 15498 and 15500

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-22

    ...: On May 3, 2010, notice was published in the Federal Register (75 FR 23242) that requests for public... Society - Brookfield Zoo, 3300 Golf Road, Brookfield, IL 60513, and the Georgia Aquarium, 225 Baker Street... Quest Bermuda, Hamilton, Bermuda, to the Brookfield Zoo, Brookfield, IL. File No. 15500 requested...

  10. 77 FR 12010 - Marine Mammals; File Nos. 1076-1789 and 14502

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-28

    ... (72 FR 13092), authorized the receipt, import and export of marine mammal specimens (cetaceans and... June 17, 2011 (72 FR 13092), authorized the importation of samples from Risso's (Grampus griseus... National Oceanic and Atmospheric Administration RIN 0648-XB040 Marine Mammals; File Nos. 1076-1789...

  11. 76 FR 51001 - Marine Mammals; File Nos. 16109 and 15575

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ... 44 species to be targeted for research are listed as threatened or endangered: blue whale (Balaenoptera musculus), fin whale (B. physalus), humpback whale (Megaptera novaeangliae), North Atlantic right whale (Eubalaena glacialis), sei whale (B. borealis), sperm whale (Physeter macrocephalus), green...

  12. 77 FR 27719 - Marine Mammals; File Nos. 16109 and 15575

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-11

    ... targeted for research are listed as threatened or endangered: Blue whale (Balaenoptera musculus), fin whale... species to be targeted for research are listed as threatened or endangered: Blue whale, fin whale... was published in the Federal Register (76 FR 51001) that requests for permits to conduct research...

  13. 76 FR 51945 - Endangered Species; File No. 16548

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-19

    ... National Oceanic and Atmospheric Administration RIN 0648-XA648 Endangered Species; File No. 16548 AGENCY... Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No. 16548 from the list of...- 0376, or by email to NMFS.Pr1Comments@noaa.gov . Please include the File No. 16548 in the subject...

  14. 76 FR 27306 - Endangered Species; File No. 15661

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    ... National Oceanic and Atmospheric Administration RIN 0648-XA425 Endangered Species; File No. 15661 AGENCY... requested under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq... Permits for Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File...

  15. 78 FR 50395 - Endangered Species; File Nos. 17557 and 17273

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-19

    ... INFORMATION: On May 31, 2013, notice was published in the Federal Register (78 FR 32622) that requests for a..., pinnipeds (except for walrus), sea turtles (in the water), smalltooth (Pristis pectinata) and largetooth...

  16. 76 FR 80890 - Endangered Species; File Nos. 13599 and 1614

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-27

    ...-01, issued on September 20, 2010 (73 FR 78724), authorizes the permit holder to receive, import...-01, (73 FR 25668) issued on April 30, 2008 authorizes the permit holder to collect, receive and... include all cetaceans, pinnipeds (except for walrus), sea turtles (in the water), smalltooth...

  17. 77 FR 21753 - Endangered Species; File Nos. 13599 and 1614

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-11

    ... Highway, Room 13705, Silver Spring, MD 20910; phone (301) 427-8401; fax (301) 713-0376; Northeast Region, NMFS, One Blackburn Drive, Gloucester, MA 01930- 2298; phone (978) 281-9300; fax (978) 281-9394; and Southeast Region, NMFS, 263 13th Ave South, St. Petersburg, FL 33701; phone (727) 824-5312; fax (727)...

  18. 78 FR 17640 - Endangered Species; File Nos. 17367 and 17364

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-22

    ... FR 67631) that requests for scientific research permits to take shortnose sturgeon and/or Atlantic.... Research would include, but is not limited to, nutrition, physiology, propagation, contaminants, genetics... research animals for studies related to tagging, tracking, behavior, physiology, genetics,...

  19. 77 FR 67631 - Endangered Species; File Nos. 17367 and 17364

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-13

    ... the USFWS, Northeast Fishery Center, PO Box 75, Lamar, PA 16848 [Michael Millard: Responsible Party.... Dated: November 7, 2012. P. Michael Payne, Chief, Permits and Conservation Division, Office of...

  20. 75 FR 33578 - Endangered Species; File Nos. 14508 and 14655

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-14

    ... September 29, 2009, notice was published in the Federal Register (74 FR 38169 and 74 FR 49851) that requests... consistent with the purposes and policies set forth in section 2 of the ESA. Dated: June 8, 2010. P....

  1. 76 FR 35842 - Endangered Species; File No. 15685

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-20

    ... National Oceanic and Atmospheric Administration RIN 0648-XA502 Endangered Species; File No. 15685 AGENCY... (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No. 15685 from the list of..., Conservation and Education Division By e-mail to NMFS.Pr1Comments@noaa.gov (include the File No. in the...

  2. 75 FR 13488 - Endangered Species; File No. 14949

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-22

    ... National Oceanic and Atmospheric Administration RIN 0648-XV33 Endangered Species; File No. 14949 AGENCY...://apps.nmfs.noaa.gov/ , and then selecting File No. 14949 from the list of available applications. These... the subject line of the e-mail comment the following document identifier: File No. 14949. FOR...

  3. 77 FR 58812 - Endangered Species; File No. 17316

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-24

    ... National Oceanic and Atmospheric Administration RIN 0648-XC252 Endangered Species; File No. 17316 AGENCY... page, https://apps.nmfs.noaa.gov , and then selecting File No. 17316 from the list of available... By email to NMFS.Pr1Comments@noaa.gov (include the File No. in the subject line of the email),...

  4. 77 FR 34349 - Endangered Species; File No. 16803

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ... National Oceanic and Atmospheric Administration RIN 0648-XC058 Endangered Species; File No. 16803 AGENCY... Permits for Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No... the Chief, Permits and Conservation Division by email to NMFS.Pr1Comments@noaa.gov (include the...

  5. 78 FR 4494 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing of Amendment Nos. 2 and 3...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-22

    ... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing of Amendment Nos. 2 and 3...\\ See Securities Exchange Act Release No. 68022 (October 9, 2012), 77 FR 62572 (``Notice''). \\5\\ See Securities Exchange Act Release No. 68313 (November 28, 2012), 77 FR 71853 (December 4, 2012). \\6\\...

  6. 77 FR 21751 - Endangered Species; File No. 16645

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XB152 Endangered Species; File No. 16645 AGENCY... comments will be accepted in Microsoft Word or Excel, WordPerfect, or Adobe PDF file formats only....

  7. 78 FR 41034 - Endangered Species; File No. 18102

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-09

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XC711 Endangered Species; File No. 18102 AGENCY...). Attachments to electronic comments will be accepted in Microsoft Word, Excel, or Adobe PDF file formats...

  8. 75 FR 13256 - Endangered Species; File No. 14176

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-19

    ... National Oceanic and Atmospheric Administration RIN 0648-XV28 Endangered Species; File No. 14176 AGENCY... permit is requested under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C... Applications and Permits for Protected Species (APPS) home page, https://apps.nmfs.noaa.gov/ , and...

  9. 76 FR 18725 - Endangered Species; File No. 16174

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-05

    ... National Oceanic and Atmospheric Administration RIN 0648-XA348 Endangered Species; File No. 16174 AGENCY... subject permit is requested under the authority of the Endangered Species Act of 1973, as amended (ESA; 16... endangered and threatened species (50 CFR 222-226). Dr. Salmon proposes to characterize juvenile green...

  10. 78 FR 13642 - Endangered Species; File No. 17506

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-28

    ... National Oceanic and Atmospheric Administration RIN 0648-XC518 Endangered Species; File No. 17506 AGENCY... INFORMATION: The subject permit is requested under the authority of the Endangered Species Act of 1973, as... of endangered and threatened species (50 CFR parts 222-226). The applicant requests a 5-year...

  11. 76 FR 66042 - Endangered Species; File No. 1551

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-25

    ... National Oceanic and Atmospheric Administration RIN 0648-XA785 Endangered Species; File No. 1551 AGENCY... of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.) and the regulations governing the taking, importing, and exporting of endangered and threatened species (50 CFR 222-226)....

  12. 75 FR 21601 - Endangered Species; File No. 14604

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... National Oceanic and Atmospheric Administration RIN 0648-XV94 Endangered Species; File No. 14604 AGENCY... Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.) and the regulations governing the taking, importing, and exporting of endangered and threatened species (50 CFR parts 222-226)....

  13. 76 FR 76950 - Endangered Species; File No. 16134

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-09

    ... National Oceanic and Atmospheric Administration RIN 0648-XA848 Endangered Species; File No. 16134 AGENCY.... SUPPLEMENTARY INFORMATION: The subject permit is requested under the authority of the Endangered Species Act of... exporting of endangered and threatened species (50 CFR parts 222-226). The applicant requests a...

  14. 77 FR 55194 - Endangered Species; File No. 17095

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-07

    ... National Oceanic and Atmospheric Administration RIN 0648-XB155 Endangered Species; File No. 17095 AGENCY... issued under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq... endangered or threatened species, and (3) is consistent with the purposes and policies set forth in section...

  15. 77 FR 57559 - Endangered Species; File No. 13330

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-18

    ... National Oceanic and Atmospheric Administration RIN 0648-XB144 Endangered Species; File No. 13330 AGENCY... modification has been granted under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U... the disadvantage of such endangered or threatened species, and (3) is consistent with the purposes...

  16. 78 FR 29114 - Endangered Species; File No. 17304

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-17

    ... National Oceanic and Atmospheric Administration RIN 0648-XC667 Endangered Species; File No. 17304 AGENCY... INFORMATION: The subject permit is requested under the authority of the Endangered Species Act of 1973, as... of endangered and threatened species (50 CFR parts 222-226). The applicant requests a...

  17. 78 FR 39258 - Endangered Species; File No. 18069

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-01

    ... National Oceanic and Atmospheric Administration RIN 0648-XC725 Endangered Species; File No. 18069 AGENCY... permit is requested under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C... Features box on the Applications and Permits for Protected Species (APPS) home page,...

  18. 75 FR 26715 - Endangered Species; File No. 1596

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ... National Oceanic and Atmospheric Administration RIN 0648-XW36 Endangered Species; File No. 1596 AGENCY... the Endangered Species Act of 1973, as amended (16 U.S.C. 1531 et seq.) and the regulations governing the taking, importing, and exporting of endangered and threatened species (50 CFR 222-226). Permit...

  19. 77 FR 31586 - Endangered Species; File No. 16556

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-29

    ... National Oceanic and Atmospheric Administration RIN 0648-XC037 Endangered Species; File No. 16556 AGENCY.... SUPPLEMENTARY INFORMATION: The subject permit is requested under the authority of the Endangered Species Act of... exporting of endangered and threatened species (50 CFR parts 222-226). The NEFSC requests a five-year...

  20. 77 FR 72326 - Endangered Species; File No. 17381

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-05

    ... National Oceanic and Atmospheric Administration RIN 0648-XC372 Endangered Species; File No. 17381 AGENCY... INFORMATION: The subject permit is requested under the authority of the Endangered Species Act of 1973, as... of endangered and threatened species (50 CFR 222-226). The applicant requests a 5-year permit...

  1. 78 FR 38952 - Endangered Species; File No. 17506

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-28

    ... National Oceanic and Atmospheric Administration RIN 0648-XC518 Endangered Species; File No. 17506 AGENCY... Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.) and the regulations governing the taking, importing, and exporting of endangered and threatened species (50 CFR parts 222-226)....

  2. 78 FR 17355 - Endangered Species; File No. 17787

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-21

    ... National Oceanic and Atmospheric Administration RIN 0648-XC576 Endangered Species; File No. 17787 AGENCY... INFORMATION: The subject permit is requested under the authority of the Endangered Species Act of 1973, as... of endangered and threatened species (50 CFR parts 222-226). The applicant proposes to gather...

  3. 76 FR 77780 - Endangered Species; File No. 10022

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-14

    ... National Oceanic and Atmospheric Administration RIN 0648-XA867 Endangered Species; File No. 10022 AGENCY... the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.) and the regulations governing the taking, importing, and exporting of endangered and threatened species (50 CFR 222-226)....

  4. 75 FR 22106 - Endangered Species; File No. 14510

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-27

    ... National Oceanic and Atmospheric Administration RIN 0648-XW06 Endangered Species; File No. 14510 AGENCY... been issued under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531... disadvantage of such endangered or threatened species, and (3) is consistent with the purposes and policies...

  5. 78 FR 57132 - Endangered Species; File No. 16230

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-17

    ... National Oceanic and Atmospheric Administration RIN 0648-XC289 Endangered Species; File No. 16230 AGENCY... incidental take of sea turtles listed under the Endangered Species Act (ESA) associated with commercial and..., importing, and exporting of endangered and threatened species (50 CFR parts 222-226). This permit...

  6. 76 FR 32144 - Endangered Species; File No. 15677

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-03

    ... National Oceanic and Atmospheric Administration RIN 0648-XA467 Endangered Species; File No. 15677 AGENCY... permit has been issued under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S... 30, 2010, notice was published in the Federal Register (75 FR 74003) that a scientific...

  7. 76 FR 77781 - Endangered Species; File No. 15802

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-14

    ... National Oceanic and Atmospheric Administration RIN 0648-XA603 Endangered Species; File No. 15802 AGENCY... under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.) and the regulations governing the taking, importing, and exporting of endangered and threatened...

  8. 76 FR 19052 - Endangered Species; File No. 14344

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-06

    ... National Oceanic and Atmospheric Administration RIN 0648-XA340 Endangered Species; File No. 14344 AGENCY..., importing, and exporting of endangered and threatened species (50 CFR parts 222-226). The permit authorizes.... SUPPLEMENTARY INFORMATION: On August 27, 2009, notice was published in the Federal Register (74 FR 43679) that...

  9. 78 FR 26323 - Endangered Species; File No. 17183

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-06

    ... National Oceanic and Atmospheric Administration RIN 0648-XC078 Endangered Species; File No. 17183 AGENCY... under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.) and the regulations governing the taking, importing, and exporting of endangered and threatened...

  10. 75 FR 61133 - Endangered Species; File No. 14176

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-04

    ... National Oceanic and Atmospheric Administration RIN 0648-XZ31 Endangered Species; File No. 14176 AGENCY... issued under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq... Register (75 FR 13256) that a request for a scientific research permit to take shortnose sturgeon had...

  11. 77 FR 61745 - Endangered Species; File No. 16803

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-11

    ... National Oceanic and Atmospheric Administration RIN 0648-XC058 Endangered Species; File No. 16803 AGENCY... issued under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq... for in good faith, (2) will not operate to the disadvantage of such endangered or threatened...

  12. 78 FR 3882 - Endangered Species; File No. 13543

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-17

    ... National Oceanic and Atmospheric Administration RIN 0648-XJ40 Endangered Species; File No. 13543 AGENCY... requested under the authority of the Endangered Species Act of 1973, as amended (16 U.S.C. 1531 et seq.) and the regulations governing the taking, importing, and exporting of endangered and threatened...

  13. 75 FR 7443 - Endangered Species; File No. 14381

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-19

    ... National Oceanic and Atmospheric Administration RIN 0648-XU26 Endangered Species; File No. 14381 AGENCY... issued under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq...: On May 22, 2009, notice was published in the Federal Register (74 FR 23995) that a request for...

  14. 75 FR 61424 - Endangered Species; File No. 15596

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-05

    ... National Oceanic and Atmospheric Administration RIN 0648-XZ37 Endangered Species; File No. 15596 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration (NOAA), Commerce... shortnose sturgeon life history and the reasons for the species decline. The proposed project to...

  15. 77 FR 15997 - Endangered Species; File No. 15672

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-19

    ..., notice was published in the Federal Register (76 FR 23305) that a request for a scientific research... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XB083 Endangered Species; File No. 15672...

  16. 77 FR 1062 - Endangered Species; File No. 16146

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-09

    ... Federal Register (76 FR 44306) that a request for a scientific research permit to take loggerhead, green... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA900 Endangered Species; File No. 16146...

  17. 77 FR 24686 - Endangered Species; File No. 15634

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-25

    ... Register (76 FR 58471) that a request for a scientific research permit to take leatherback sea turtles had... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA714 Endangered Species; File No. 15634...

  18. 78 FR 2659 - Endangered Species; File No. 16645

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-14

    ... INFORMATION: On April 11, 2012, notice was published in the Federal Register (77 FR 21751) that a request for... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XB152 Endangered Species; File No. 16645...

  19. 75 FR 78227 - Endangered Species; File No. 14400

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-15

    ... INFORMATION: On August 27, 2009, notice was published in the Federal Register (74 FR 43679) that a request for... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA085 Endangered Species; File No. 14400...

  20. 78 FR 22517 - Endangered Species; File No. 16549

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-16

    .... SUPPLEMENTARY INFORMATION: On April 11, 2012, notice was published in the Federal Register (77 FR 21750) that a... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XB155 Endangered Species; File No. 16549...

  1. 77 FR 30261 - Endangered Species; File No. 16306

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-22

    ..., 2011, notice was published in the Federal Register (76 FR 58471) that a request for a scientific... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA712 Endangered Species; File No. 16306...

  2. Phylogenetic distinction of iNOS and IDO function in mesenchymal stem cell-mediated immunosuppression in mammalian species.

    PubMed

    Su, J; Chen, X; Huang, Y; Li, W; Li, J; Cao, K; Cao, G; Zhang, L; Li, F; Roberts, A I; Kang, H; Yu, P; Ren, G; Ji, W; Wang, Y; Shi, Y

    2014-03-01

    Mammalian mesenchymal stem cells (MSCs) have been shown to be strongly immunosuppressive in both animal disease models and human clinical trials. We have reported that the key molecule mediating immunosuppression by MSCs is species dependent: indoleamine 2,3-dioxygenase (IDO) in human and inducible nitric oxide synthase (iNOS) in mouse. In the present study, we isolated MSCs from several mammalian species, each of a different genus, and investigated the involvement of IDO and iNOS during MSC-mediated immunosuppression. The characterization of MSCs from different species was by adherence to tissue culture plastic, morphology, specific marker expression, and differentiation potential. On the basis of the inducibility of IDO and iNOS by inflammatory cytokines in MSCs, the tested mammalian species fall into two distinct groups: IDO utilizers and iNOS utilizers. MSCs from monkey, pig, and human employ IDO to suppress immune responses, whereas MSCs from mouse, rat, rabbit, and hamster utilize iNOS. Interestingly, based on the limited number of species tested, the iNOS-utilizing species all belong to the phylogenetic clade, Glires. Although the evolutionary significance of this divergence is not known, we believe that this study provides critical guidance for choosing appropriate animal models for preclinical studies of MSCs.

  3. 78 FR 2955 - Marine Mammals; File Nos. 14451, 14353, and 13846

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-15

    ... blue whales (Balaenoptera musculus), fin whales (B. physalus), humpback whales (Megaptera novaeangliae... Darling, Ph.D., Whale Trust, P.O. Box 384, Tofino, BC V0R2Z0, Canada, have applied for amendments to... species (50 CFR 222-226). Permit No. 14451, issued on July 14, 2010 (75 FR 43151), authorizes the...

  4. 78 FR 30872 - Marine Mammals; File Nos. 14451, 14353, and 13846

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-23

    .... Researchers target numerous cetacean species including endangered blue whales (Balaenoptera musculus), fin... Insular Hawaiian false killer whales under the ESA. Permit No. 14353, issued on July 14, 2010 (75 FR 43151... 04609; and Jim Darling, Ph.D., Whale Trust, P.O. Box 384, Tofino, BC V0R2Z0, Canada, for...

  5. 76 FR 68161 - Marine Mammals; File Nos. 16163, 16160, and 15569

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-03

    ... are listed as endangered or have a stock listed as endangered: blue whale (Balaenoptera musculus), fin... species that are listed as endangered include the blue whale, fin whale, sei whale, humpback whale, and...], 2725 Montlake Blvd. East, Seattle, WA 98112-2097; The Whale Museum (Jenny Atkinson, Responsible...

  6. 76 FR 23571 - Marine Mammals and Endangered Species; File Nos. 15415 and 14622

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-27

    ... December 10, 2010, notice was published in the Federal Register (75 FR 76956) that a request for a permit... D. Kraus, Ph.D. . On March 4, 2010, notice was published in the Federal Register (75 FR 9868) that a... transmitter attachment, ultrasound and/or laparoscopy and organ sampling before release. In compliance...

  7. 75 FR 9580 - Marine Mammals and Endangered Species; File Nos. 13544 and 14586

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-03

    ...), humpback whales (Megaptera novaengliae), and the North Atlantic right whale (Eubalaena glacialis). The... Wyneken, Florida Atlantic University, Boca Raton, FL 33431, has applied in due form to conduct scientific... Permit No. 13544, issued on April 17, 2009 (74 FR 18354) is requested under the authority of...

  8. 75 FR 76704 - Endangered Species; File Nos. 13307, 13544, and 14586

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-09

    ... given that NMFS has issued a permit and two permit modifications to take sea turtles and marine mammals... published in the Federal Register (75 FR 9580) that a request for a scientific research permit to take sea... Jeffrey Schmid, PhD, Conservancy of Southwest Florida, Naples, FL, for sea turtle research. On April...

  9. 75 FR 16428 - Endangered Species; File Nos. 15112 and 13307-02

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ... ridley (Lepidochelys kempii), green (Chelonia mydas), and hawksbill (Eretmochelys imbricata) sea turtles... modification to scientific research Permit No. 13307-01 to take green sea turtles. DATES: Written, telefaxed... composition of populations of sea turtles found in the commercial fishing areas of the Northwest...

  10. 77 FR 13097 - Endangered Species; File Nos. 15661, 10027, and 15685

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-05

    ... sea turtles had been submitted by the Center for Biodiversity and Conservation, American Museum of... hawksbill (Eretmochelys imbricata) sea turtles for scientific research. See SUPPLEMENTARY INFORMATION for... sea turtles had been submitted by the Commonwealth of the Northern Mariana Islands (CNMI) Division...

  11. 78 FR 23225 - Endangered Species; File Nos. 14759-01 and 16375-01

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-18

    ... issued August 20, 2010 (75 FR 53278), and Permit No. 16375 was issued on April 6, 2012 (77 FR 21754) to... rivers (Chowan, Roanoke, Tar-Pamlico, Neuse, and Cape Fear) and estuaries (Albemarle Sound) using non... characterizing spawning activity in the Roanoke and/or Cape Fear Rivers. Specifically, it is proposed...

  12. 76 FR 58469 - Endangered Species; File Nos. 16526, 16323, 16436, 16422, 16438, 16431, 16507, 16547, 16375...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-21

    ..., 16436, 16422, 16438, 16431, 16507, 16547, 16375, 16442, 16482, and 16508. AGENCY: National Marine.... Gail Wippelhauser, PhD, of the Maine Department of Marine Resources, 21 State House Station, Augusta... telemetry tag. Tom Savoy of the Connecticut Department of Environmental Protection, Marine Fisheries,...

  13. iNOS null MRL+/+ mice show attenuation of trichloroethene-mediated autoimmunity: contribution of reactive nitrogen species and lipid-derived reactive aldehydes.

    PubMed

    Wang, Gangduo; Wakamiya, Maki; Wang, Jianling; Ansari, G A S; Firoze Khan, M

    2015-12-01

    Earlier studies from our laboratory in MRL+/+ mice suggest that free radicals, especially overproduction of reactive nitrogen species (RNS) and lipid-derived reactive aldehydes (LDRAs), are associated with trichloroethene (TCE)-mediated autoimmune response. The current study was undertaken to further assess the contribution of RNS and LDRAs in TCE-mediated autoimmunity by using iNOS-null MRL+/+ mice. iNOS-null MRL+/+ mice were obtained by backcrossing iNOS-null mice (B6.129P2-Nos2(tm1Lau)/J) to MRL +/+ mice. Female MRL+/+ and iNOS-null MRL+/+ mice were given TCE (10 mmol/kg, i.p., every 4(th) day) for 6 weeks; their respective controls received corn oil only. TCE exposure led to significantly increased iNOS mRNA in livers, iNOS protein in livers and sera, increased nitrotyrosine (NT) formation in both livers and sera, induction of MDA-/HNE-protein adducts in livers and their respective antibodies in sera along with significant increases in serum antinuclear antibodies (ANA) and anti-dsDNA in MRL+/+ mice. Even though in iNOS-null MRL+/+ mice, the iNOS and NT levels were negligible in both TCE-treated and untreated groups, TCE treatment still led to significant increases in MDA-/HNE-protein adducts and their respective antibodies along with increases in serum ANA and anti-dsDNA compared to controls. Most remarkably, the increases in serum ANA and anti-dsDNA induced by TCE in the iNOS-null MRL+/+ mice were significantly less pronounced compared to that in MRL+/+ mice. Our results provide further evidence that both RNS and LDRAs contribute to TCE-induced autoimmunity in MRL+/+ mice, and iNOS deficiency attenuates this autoimmune response.

  14. 76 FR 58471 - Endangered Species; File No. 16306

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-21

    ... species (50 CFR 222-226). The applicant proposes to collect information on shortnose sturgeon life history in the Gulf of Maine, including movement, natal river origin, and other vital population...

  15. 76 FR 34967 - Endangered Species; File No. 10027

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-15

    .... 10027, issued on July 30, 2008 (73 FR 44224), is requested under the authority of the Endangered Species... the Center for Biodiversity and Conservation, American Museum of Natural History (Responsible...

  16. 75 FR 11862 - Endangered Species; File No. 14759

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.), and the regulations... (Albemarle Sound) using non-lethal sampling methods combining hydroacoustic surveys (side-scan, DIDSON)...

  17. 78 FR 66901 - Endangered Species; File No. 16482-01

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-07

    ... threatened species (50 CFR parts 222-226). Permit No. 16482 was issued April 6, 2012 (77 FR 21754) to the... sectioned, laparoscoped, and implanted with an internal acoustic tag. Incidental mortality of serious...

  18. 77 FR 65673 - Endangered Species; File No. 16248

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-30

    .... ACTION: Notice; receipt of application. SUMMARY: Notice is hereby given that the Riverbanks Zoo and... species (50 CFR 222-226). The Riverbanks Zoo and Garden is requesting a permit to continue...

  19. 76 FR 44306 - Endangered Species; File No. 16146

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-25

    ...). ACTION: Notice; receipt of application. SUMMARY: Notice is hereby given that Kristen Hart, U.S... under the ] authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq... loggerhead sea turtles at Buck Island Reef National Monument, U.S. Virgin Islands. The purposes of...

  20. 78 FR 6072 - Endangered Species; File No. 17095-01

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-29

    ..., 2012 (77 FR 21750), is requested under the authority of the Endangered Species Act of 1973, as amended (16 U.S.C. 1531 et seq.) and the regulations governing the taking, importing, and exporting of..., measure, weigh, scan for tags, insert passive integrated transponder and dart tags, photograph,...

  1. 78 FR 17359 - Endangered Species; File No. 17095-01

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-21

    ...: On January 29, 2013, notice was published in the Federal Register (78 FR 6072) that a request for a... of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.) and the regulations...). Researchers are authorized to non-lethally capture, handle, measure, weigh, scan for tags, insert...

  2. 76 FR 45230 - Endangered Species; File No. 15802

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-28

    ... Conservation Commission, 100 Eighth Avenue, SE, St. Petersburg, FL 33701 , has applied in due form for a permit to take smalltooth sawfish and listed sea turtle species for purposes of scientific research. DATES... (Dermochelys coriacea), and loggerhead (Caretta caretta) sea turtles. Sea turtles would be...

  3. 78 FR 5779 - Endangered Species; File No. 16248

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-28

    ... INFORMATION: On October 30, 2012, notice was published in the Federal Register (77 FR 65673) that a request.... ACTION: Issuance of permit. SUMMARY: Notice is hereby given that the Riverbanks Zoo and Garden, P.O. Box... exporting of endangered and threatened species (50 CFR parts 222-226). The Riverbanks Zoo and Garden...

  4. 76 FR 48146 - Endangered Species; File No. 1551

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-08

    ... coriacea) sea turtles in coastal and inshore waters of the North Atlantic, Gulf of Mexico and Caribbean Sea... threatened species (50 CFR 222-226). Permit No. 1551, issued on July 24, 2008 (73 FR 44225), authorizes... the permit to increase the number of sea turtles (an additional 75 leatherback, 1,150 loggerhead,...

  5. 78 FR 32623 - Endangered Species; File No. 17452

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ... permit to take shortnose (Acipenser brevirostrum) and Atlantic sturgeon (Acipenser oxyrinchus oxyrinchus... shortnose sturgeon. For each species, up to 20 adult and juvenile animals would be collected annually using gill nets. Once captured, sturgeon would be measured, weighed, tissue sampled, and passive...

  6. 76 FR 31597 - Endangered Species; File No. 15614

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-01

    ..., notice was published in the Federal Register (75 FR 78974) that a request for a scientific research... shortnose sturgeon for purposes of scientific research. ADDRESSES: The permit and related documents are... threatened species (50 CFR parts 222-226). The applicant is authorized to conduct a five-year...

  7. Role of reactive oxygen species in the signalling cascade of cyclosporine A-mediated up-regulation of eNOS in vascular endothelial cells

    PubMed Central

    López-Ongil, S; Hernández-Perera, O; Navarro-Antolín, J; Pérez de Lema, G; Rodríguez-Puyol, M; Lamas, S; Rodríguez-Puyol, D

    1998-01-01

    Cyclosporine A (CsA) increases eNOS mRNA expression in bovine cultured aortic endothelial cells (BAEC). As some effects of CsA may be mediated by reactive oxygen species (ROS), present experiments were devoted to test the hypothesis that the CsA-induced eNOS up-regulation could be dependent on an increased synthesis of ROS.CsA induced a dose-dependent increase of ROS synthesis, with the two fluorescent probes used, DHR123 (CsA 1 μM: 305±7% over control) and H2DCFDA (CsA 1 μM: 178±6% over control).Two ROS generating systems, xanthine plus xanthine oxidase (XXO) and glucose oxidase (GO), increased the expression of eNOS mRNA in BAEC, an effect which was maximal after 8 h of incubation (XXO: 168±21% of control values. GO: 208±18% of control values). The ROS-dependent increased eNOS mRNA expression was followed by an increase in eNOS activity.The effect of CsA on eNOS mRNA expression was abrogated by catalase, and superoxide dismutase (SOD). In contrast, the antioxidant PDTC augmented eNOS mRNA expression, both in basal conditions and in the presence of CsA.The potential participation of the transcription factor AP-1 was explored. Electrophoretic mobility shift assays were consistent with an increase in AP-1 DNA-binding activity in BAEC treated with CsA or glucose oxidase.The present results support a role for ROS, particularly superoxide anion and hydrogen peroxide, as mediators of the CsA-induced eNOS mRNA up-regulation. Furthermore, they situate ROS as potential regulators of gene expression in endothelial cells, both in physiological and pathophysiological situations. PMID:9647467

  8. 75 FR 61133 - Marine Mammals and Endangered Species; File Nos. 808-1735, 14233, 14506, 14603, and 14726

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-04

    .... SUPPLEMENTARY INFORMATION: On March 11, 2010, notice was published in the Federal Register (75 FR 11516) that a... submitted by Andrew Read, Ph.D. . On September 10, 2009, notice was published in the Federal Register (74 FR... Federal Register (74 FR 66618) that a request for a permit to conduct research on green (Chelonia...

  9. 76 FR 30309 - Marine Mammals and Endangered Species; File Nos. 14245, 1596-03, and 14726-01

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-25

    ...-spill Natural Resources Damage Assessment of the BP Deepwater Horizon event. The modified permit is..., 2010 and December 29, 2010, notices were published in the Federal Register (75 FR 26715 and 81970.... On May 12, 2010, notice was published in the Federal Register (75 FR 26715) that a modification...

  10. Reactive oxygen species- and nitric oxide-mediated lung inflammation and mitochondrial dysfunction in wild-type and iNOS-deficient mice exposed to diesel exhaust particles.

    PubMed

    Zhao, Hongwen; Ma, Joseph K; Barger, Mark W; Mercer, Robert R; Millecchia, Lyndell; Schwegler-Berry, Diane; Castranova, Vince; Ma, Jane Y

    2009-01-01

    Pulmonary responses to diesel exhaust particles (DEP) exposure are mediated through enhanced production of reactive oxygen species (ROS) and nitric oxide (NO) by alveolar macrophages (AM). The current study examined the differential roles of ROS and NO in DEP-induced lung injury using C57B/6J wild-type (WT) and inducible NO synthase knockout (iNOS KO) mice. Mice exposed by pharyngeal aspiration to DEP or carbon black particles (CB) (35 mg/kg) showed an inflammatory profile that included neutrophil infiltration, increased lactate dehydrogenase (LDH) activity, and elevated albumin content in bronchoalveolar lavage fluid (BALF) at 1, 3, and 7 d postexposure. The organic extract of DEP (DEPE) did not induce an inflammatory response. Comparing WT to iNOS KO mice, the results show that NO enhanced DEP-induced neutrophils infiltration and plasma albumin content in BALF and upregulated the production of the pro-inflammatory cytokine interleukin 12 (IL-12) by AM. DEP-exposed AM from iNOS KO mice displayed diminished production of IL-12 and, in response to ex vivo lipopolysaccharide (LPS) challenge, decreased production of IL-12 but increased production of IL-10 when compared to cells from WT mice. DEP, CB, but not DEPE, induced DNA damage and mitochondria dysfunction in AM, however, that is independent of cellular production of NO. These results demonstrate that DEP-induced immune/inflammatory responses in mice are regulated by both ROS- and NO-mediated pathways. NO did not affect ROS-mediated mitochondrial dysfunction and DNA damage but upregulated IL-12 and provided a counterbalance to the ROS-mediated adaptive stress response that downregulates IL-12 and upregulates IL-10. PMID:19267316

  11. Permanent-File-Validation Utility Computer Program

    NASA Technical Reports Server (NTRS)

    Derry, Stephen D.

    1988-01-01

    Errors in files detected and corrected during operation. Permanent File Validation (PFVAL) utility computer program provides CDC CYBER NOS sites with mechanism to verify integrity of permanent file base. Locates and identifies permanent file errors in Mass Storage Table (MST) and Track Reservation Table (TRT), in permanent file catalog entries (PFC's) in permit sectors, and in disk sector linkage. All detected errors written to listing file and system and job day files. Program operates by reading system tables , catalog track, permit sectors, and disk linkage bytes to vaidate expected and actual file linkages. Used extensively to identify and locate errors in permanent files and enable online correction, reducing computer-system downtime.

  12. 76 FR 51439 - Self-Regulatory Organizations; National Stock Exchange, Inc.; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-18

    ... Release Nos. 62252 (June 10, 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS-2010-014; SR-EDGA- 2010... Release Nos. 62884 (September 10, 2010), 75 FR 56618 (September 16, 2010) (File Nos. SR-BATS-2010-018; SR... Securities Exchange Act Release No. 62883 (September 10, 2010), 75 FR 56608 (September 16, 2010)...

  13. 76 FR 51447 - Self-Regulatory Organizations; Chicago Stock Exchange, Inc.; Notice of Filing of Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-18

    ... Exchange Act Release Nos. 62252 (June 10, 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS-2010-014... Exchange Act Release Nos. 62884 (September 10, 2010), 75 FR 56618 (September 16, 2010) (File Nos. SR-BATS...-2010-08); and Securities Exchange Act Release No. 62883 (September 10, 2010), 75 FR 56608 (September...

  14. 77 FR 21553 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-10

    ... Opportunity Cost for Wind to be effective 6/1/2012. Filed Date: 4/2/12. Accession Number: 20120402-5157... Operational Penalty Assessments and Distributions as Required by Order Nos. 890 and 890-A. Filed Date: 4/2/12... Operational Penalty Assessments and Distributions as Required by Order Nos. 890 and 890-A in OA08-100....

  15. 76 FR 29229 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-20

    ... submits tariff filing per 35.13(a)(2)(iii: Service Agreement Nos. 584, 585, and 588--PPL Montana, LLC to... Nos. 586 and 587--PPL Montana, LLC to be effective 5/10/2011. Filed Date: 05/12/2011. Accession...

  16. Anti-apoptotic mechanism of Bacoside rich extract against reactive nitrogen species induced activation of iNOS/Bax/caspase 3 mediated apoptosis in L132 cell line.

    PubMed

    Anand, T; Pandareesh, M D; Bhat, Pratiksha V; Venkataramana, M

    2014-10-01

    Nitric oxide is a highly reactive free radical gas that reacts with a wide range of bio-molecules to produce reactive nitrogen species and exerts nitrative stress. Bacopa monniera is a traditional folk and ayurvedic medicine known to alleviate a variety of disorders. Aim of the present study is to evaluate the protective propensity of Bacopa monniera extract (BME) through its oxido-nitrosative and anti-apoptotic mechanism to attenuate sodium nitroprusside (SNP)-induced apoptosis in a human embryonic lung epithelial cell line (L132). Our results elucidate that pre-treatment of L132 cells with BME ameliorates the mitochondrial and plasma membrane damage induced by SNP as evidenced by MTT and LDH leakage assays. BME pre-treatment inhibited NO generation by down-regulating inducible nitric oxide synthase expression. BME exhibited potent antioxidant activity by up-regulating the antioxidant enzymes. SNP-induced damage to cellular, nuclear and mitochondrial integrity was also restored by BME, which was confirmed by ROS estimation, comet assay and mitochondrial membrane potential assays respectively. BME pre-treatment efficiently attenuated the SNP-induced apoptotic biomarkers such as Bax, cytochrome-c and caspase-3, which orchestrate the proteolytic damage of the cell. By considering all these findings, we report that BME protects L132 cells against SNP-induced toxicity via its free radical scavenging and anti-apoptotic mechanism.

  17. mNos2 deletion and human NOS2 replacement in Alzheimer disease models.

    PubMed

    Colton, Carol A; Wilson, Joan G; Everhart, Angela; Wilcock, Donna M; Puoliväli, Jukka; Heikkinen, Taneli; Oksman, Juho; Jääskeläinen, Olli; Lehtimäki, Kimmo; Laitinen, Teemu; Vartiainen, Nina; Vitek, Michael P

    2014-08-01

    Understanding the pathophysiologic mechanisms underlying Alzheimer disease relies on knowledge of disease onset and the sequence of development of brain pathologies. We present a comprehensive analysis of early and progressive changes in a mouse model that demonstrates a full spectrum of characteristic Alzheimer disease-like pathologies. This model demonstrates an altered immune redox state reminiscent of the human disease and capitalizes on data indicating critical differences between human and mouse immune responses, particularly in nitric oxide levels produced by immune activation of the NOS2 gene. Using the APPSwDI(+)/(+)mNos2(-/-) (CVN-AD) mouse strain, we show a sequence of pathologic events leading to neurodegeneration,which include pathologically hyperphosphorylated tau in the perforant pathway at 6 weeks of age progressing to insoluble tau, early appearance of β-amyloid peptides in perivascular deposits around blood vessels in brain regions known to be vulnerable to Alzheimer disease, and progression to damage and overt loss in select vulnerable neuronal populations in these regions. The role of species differences between hNOS2 and mNos2 was supported by generating mice in which the human NOS2 gene replaced mNos2. When crossed with CVN-AD mice, pathologic characteristics of this new strain (APPSwDI(+)/(-)/HuNOS2(tg+)/(+)/mNos2(-/-)) mimicked the pathologic phenotypes found in the CVN-AD strain.

  18. mNos2 Deletion and Human NOS2 Replacement in Alzheimer Disease Models

    PubMed Central

    Colton, Carol A.; Wilson, Joan G.; Everhart, Angela; Wilcock, Donna M.; Puoliväli, Jukka; Heikkinen, Taneli; Oksman, Juho; Jääskeläinen, Olli; Lehtimäki, Kimmo; Laitinen, Teemu; Vartiainen, Nina; Vitek, Michael P.

    2014-01-01

    Abstract Understanding the pathophysiologic mechanisms underlying Alzheimer disease relies on knowledge of disease onset and the sequence of development of brain pathologies. We present a comprehensive analysis of early and progressive changes in a mouse model that demonstrates a full spectrum of characteristic Alzheimer disease–like pathologies. This model demonstrates an altered immune redox state reminiscent of the human disease and capitalizes on data indicating critical differences between human and mouse immune responses, particularly in nitric oxide levels produced by immune activation of the NOS2 gene. Using the APPSwDI+/+/mNos2−/− (CVN-AD) mouse strain, we show a sequence of pathologic events leading to neurodegeneration,which include pathologically hyperphosphorylated tau in the perforant pathway at 6 weeks of age progressing to insoluble tau, early appearance of β-amyloid peptides in perivascular deposits around blood vessels in brain regions known to be vulnerable to Alzheimer disease, and progression to damage and overt loss in select vulnerable neuronal populations in these regions. The role of species differences between hNOS2 and mNos2 was supported by generating mice in which the human NOS2 gene replaced mNos2. When crossed with CVN-AD mice, pathologic characteristics of this new strain (APPSwDI+/−/HuNOS2tg+/+/mNos2−/−) mimicked the pathologic phenotypes found in the CVN-AD strain. PMID:25003233

  19. 15. Dry Dock No. 4. Longitudinal Section. Subdivision Nos. I ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. Dry Dock No. 4. Longitudinal Section. Subdivision Nos. I and II (Frederic R. Harris, Inc., January 10, 1941). In Files of Cushman & Wakefield, Building no. 501, Philadelphia Naval Business Center. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Dry Dock No. 4, Broad Street south of Government Avenue, Philadelphia, Philadelphia County, PA

  20. 16. Dry Dock No. 4. Longitudinal Section. Subdivision Nos. III ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Dry Dock No. 4. Longitudinal Section. Subdivision Nos. III and IV (Frederic R. Harris, Inc., January 10, 1941). In Files of Cushman & Wakefield, Building no. 501, Philadelphia Naval Business Center. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Dry Dock No. 4, Broad Street south of Government Avenue, Philadelphia, Philadelphia County, PA

  1. Service building. Cross section thru dry dock nos. 4 & ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Service building. Cross section thru dry dock nos. 4 & 5 showing service bldg & 20-75-150 ton cranes (dry dock associates, May 23, 1941). In files of Cushman & Wakefield, building no. 501, Philadelphia Naval Business Center. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Service Building, Dry Docks No. 4 & 5, League Island, Philadelphia, Philadelphia County, PA

  2. 76 FR 51076 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ... Exchange Act Release Nos. 62252 (June 10, 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS-2010-014...-047); 62251 (June 10, 2010), 75 FR 34183 (June 16, 2010) (SR-FINRA-2010- 025). \\6\\ See e.g., Securities Exchange Act Release Nos. 62884 (September 10, 2010), 75 FR 56618 (September 16, 2010) (File...

  3. The NOS Challenge

    ERIC Educational Resources Information Center

    Quigley, Cassie; Buck, Gayle; Akerson, Valarie

    2011-01-01

    "The picture of a scientist is me!" exclaims first grader Kendra during a nature of science (NOS) lesson. She drew a picture of a scientist and explained that she was going to be a scientist when she grew up because she "loved to observe like a scientist." Kendra's experience was a part of a 30-day unit designed specifically for first graders.…

  4. 78 FR 17929 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-25

    ...: Cancellation of PJM Service Agreement Nos. 2861, 2986, 3145 and 3164 to be effective 2/13/2013. Filed Date: 3...: Notice of Cancellation of RS FERC No. 236 with the City of Eudora, Kansas to be effective 6/1/2013. Filed... must file in accordance with Rules 211 and 214 of the Commission's Regulations (18 CFR 385.211 and...

  5. 76 FR 51089 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing of Proposed Rule Change To...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ... FR 34186 (June 16, 2010) (File Nos. SR-BATS-2010-014; SR-EDGA- 2010-01; SR-EDGX-2010-01; SR-BX-2010... 10, 2010), 75 FR 56618 (September 16, 2010) (File Nos. SR-BATS-2010-018; SR-BX-2010-044; SR-CBOE-2010... (June 23, 2011), 76 FR 38243 (June 29, 2011) (File Nos. SR-BATS-2011-016; SR-BYX- 2011-011;...

  6. 76 FR 2174 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-12

    ... Securities Exchange Act Release No. 35993 (July 19, 1995), 60 FR 38073 (July 25, 1995) (approving File Nos..., 1998), 63 FR 64297 (November 19, 1998) (approving File Nos. SR-Amex-98-21, SR-CBOE-98-29, SR-PCX-98- 31... Price Program. See Securities Exchange Act Release No. 52960 (December 15, 2005), 70 FR 76090...

  7. 76 FR 74086 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-30

    ... Exchange Act Release No. 62252 (June 10, 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS- 2010-014...) and Securities Exchange Act Release No. 62251 (June 10, 2010), 75 FR 34183 (June 16, 2010) (SR-FINRA... Exchange Act Release No. 62884 (September 10, 2010), 75 FR 56618 (September 16, 2010) (File Nos....

  8. Expression of nitric oxide synthase (NOS) genes in channel catfish is highly regulated and time dependent after bacterial challenges.

    PubMed

    Yao, Jun; Li, Chao; Zhang, Jiaren; Liu, Shikai; Feng, Jianbin; Wang, Ruijia; Li, Yun; Jiang, Chen; Song, Lin; Chen, Ailu; Liu, Zhanjiang

    2014-07-01

    Nitric oxide is well known for its roles in immune responses. As such, its synthesizing enzymes have been extensively studied from various species including some teleost fish species. However, the NOS genes have not been characterized in channel catfish (Ictalurus punctatus). In this study, we identified and characterized three NOS genes including one NOS1 and two NOS2 genes in channel catfish. Comparing with the NOS genes from other fish species, the catfish NOS genes are highly conserved in their structural features. Phylogenetic and syntenic analyses allowed determination of NOS1 and NOS2 genes of channel catfish and their orthology relationships. Syntenic analysis, as well as the phylogenetic analysis, indicated that the two NOS2 genes of catfish were lineage-specific duplication. The NOS genes were broadly expressed in most tested tissues, with NOS1 being expressed at the highest levels in the brain, NOS2b1 highly expressed in the skin and gill, and NOS2b2 lowly expressed in most of the tested tissues. The most striking findings of this study was that the expression of the NOS genes are highly regulated after bacterial infection, with time-dependent expression patterns that parallel the migration of macrophages. After Edwardsiella ictaluri challenge, dramatically different responses among the three NOS genes were observed. NOS1 was only significantly in the skin early after infection, while NOS2b1 was rapidly upregulated in gill, but more up-regulated in trunk kidney with the progression of the disease, suggesting such differences in gene expression may be reflective of the migration of macrophages among various tissues of the infected fish. In contrast to NOS1 and NOS2b1, NOS2b2 was normally expressed at very low levels, but it is induced in the brain and liver while significantly down-regulated in most other tissues.

  9. Contribution of the nos-pdt Operon to Virulence Phenotypes in Methicillin-Sensitive Staphylococcus aureus

    PubMed Central

    Almand, Erin A.; Rivera, Frances E.; Shaw, Lindsey N.; Richardson, Anthony R.; Rice, Kelly C.

    2014-01-01

    Nitric oxide (NO) is emerging as an important regulator of bacterial stress resistance, biofilm development, and virulence. One potential source of endogenous NO production in the pathogen Staphylococcus aureus is its NO-synthase (saNOS) enzyme, encoded by the nos gene. Although a role for saNOS in oxidative stress resistance, antibiotic resistance, and virulence has been recently-described, insights into the regulation of nos expression and saNOS enzyme activity remain elusive. To this end, transcriptional analysis of the nos gene in S. aureus strain UAMS-1 was performed, which revealed that nos expression increases during low-oxygen growth and is growth-phase dependent. Furthermore, nos is co-transcribed with a downstream gene, designated pdt, which encodes a prephenate dehydratase (PDT) enzyme involved in phenylalanine biosynthesis. Deletion of pdt significantly impaired the ability of UAMS-1 to grow in chemically-defined media lacking phenylalanine, confirming the function of this enzyme. Bioinformatics analysis revealed that the operon organization of nos-pdt appears to be unique to the staphylococci. As described for other S. aureus nos mutants, inactivation of nos in UAMS-1 conferred sensitivity to oxidative stress, while deletion of pdt did not affect this phenotype. The nos mutant also displayed reduced virulence in a murine sepsis infection model, and increased carotenoid pigmentation when cultured on agar plates, both previously-undescribed nos mutant phenotypes. Utilizing the fluorescent stain 4-Amino-5-Methylamino-2',7'-Difluorofluorescein (DAF-FM) diacetate, decreased levels of intracellular NO/reactive nitrogen species (RNS) were detected in the nos mutant on agar plates. These results reinforce the important role of saNOS in S. aureus physiology and virulence, and have identified an in vitro growth condition under which saNOS activity appears to be upregulated. However, the significance of the operon organization of nos-pdt and potential

  10. Contribution of the nos-pdt operon to virulence phenotypes in methicillin-sensitive Staphylococcus aureus.

    PubMed

    Sapp, April M; Mogen, Austin B; Almand, Erin A; Rivera, Frances E; Shaw, Lindsey N; Richardson, Anthony R; Rice, Kelly C

    2014-01-01

    Nitric oxide (NO) is emerging as an important regulator of bacterial stress resistance, biofilm development, and virulence. One potential source of endogenous NO production in the pathogen Staphylococcus aureus is its NO-synthase (saNOS) enzyme, encoded by the nos gene. Although a role for saNOS in oxidative stress resistance, antibiotic resistance, and virulence has been recently-described, insights into the regulation of nos expression and saNOS enzyme activity remain elusive. To this end, transcriptional analysis of the nos gene in S. aureus strain UAMS-1 was performed, which revealed that nos expression increases during low-oxygen growth and is growth-phase dependent. Furthermore, nos is co-transcribed with a downstream gene, designated pdt, which encodes a prephenate dehydratase (PDT) enzyme involved in phenylalanine biosynthesis. Deletion of pdt significantly impaired the ability of UAMS-1 to grow in chemically-defined media lacking phenylalanine, confirming the function of this enzyme. Bioinformatics analysis revealed that the operon organization of nos-pdt appears to be unique to the staphylococci. As described for other S. aureus nos mutants, inactivation of nos in UAMS-1 conferred sensitivity to oxidative stress, while deletion of pdt did not affect this phenotype. The nos mutant also displayed reduced virulence in a murine sepsis infection model, and increased carotenoid pigmentation when cultured on agar plates, both previously-undescribed nos mutant phenotypes. Utilizing the fluorescent stain 4-Amino-5-Methylamino-2',7'-Difluorofluorescein (DAF-FM) diacetate, decreased levels of intracellular NO/reactive nitrogen species (RNS) were detected in the nos mutant on agar plates. These results reinforce the important role of saNOS in S. aureus physiology and virulence, and have identified an in vitro growth condition under which saNOS activity appears to be upregulated. However, the significance of the operon organization of nos-pdt and potential

  11. 77 FR 4033 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-26

    ..., Enserco Energy Inc., Twin Eagle Resource Management, LLC Description: Joint Application for Authorization... tariff filing per 35.13(a)(2)(iii): PJM Queue X2-082; First Revised Service Agreement Nos. 3156 and 3157... Interconnection, L.L.C. Description: PJM Interconnection, L.L.C. submits tariff filing per 35.13(a)(2)(iii):...

  12. 76 FR 67718 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-02

    ... Interconnection, L.L.C. submits tariff filing per 35.13(a)(2)(iii): Original Service Agreement No. 3083--Queue No... Interconnection, L.L.C. submits tariff filing per 35.13(a)(2)(iii): Original Service Agreement No. 3084--Queue No...'s eLibrary system by clicking on the links or querying the docket number. Any person desiring...

  13. 78 FR 21112 - Marine Mammals; File Nos. 16992 and 14535

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-09

    ... amendment to Permit No. 14535-01 (75 FR 58352) to allow the addition of TTS studies to the currently..., Ph.D., Hawaii Institute of Marine Biology, University of Hawaii, P.O. Box 1106, Kailua, HI 96734, has... of Marine Biology in Kaneohe, HI. Researchers would conduct hearing measurements using suction...

  14. 76 FR 18725 - Marine Mammals; File Nos. 14330 and 14335

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-05

    .... 14330. On January 4, 2011, notice was published in the Federal Register (76 FR 329) that a request for... published in the Federal Register (75 FR 80470) that a request for an amendment Permit No. 14335 to conduct...-surgical and hot-branding monitoring. In compliance with the National Environmental Policy Act of 1969...

  15. 75 FR 23242 - Marine Mammals; File Nos. 15498 and 15500

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-03

    ... Society - Brookfield Zoo, 3300 Golf Road, Brookfield, IL 60513, and Georgia Aquarium, 225 Baker Street, NW... Zoo, Brookfield, IL, for the purpose of public display. The Brookfield Zoo is: (1) open to the public... Marine Mammal Parks and Aquariums and the Association of Zoos and Aquariums; and (3) holds an...

  16. 78 FR 60852 - Marine Mammals; File Nos. 16239 and 17312

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ... Atlantic Ocean (including the Gulf of Mexico, western North Atlantic, Caribbean Sea, and Sargasso Seas... (77 FR 60966 and 78 FR 23538) for No. 16239 and No. 17312, respectively, that requests for permits...

  17. 77 FR 64959 - Marine Mammals; File Nos. 15777 and 17670

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-24

    ...) was made available for public comment on May 4, 2012 (77 FR 26513). In response to public comments... given that the NMFS Northeast Fisheries Science Center, Woods Hole, MA (Responsible Party: Michael... an environmental assessment or environmental impact statement. Dated: October 18, 2012. P....

  18. 76 FR 9384 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-17

    ...), 75 FR 69489 (November 12, 2010)(NASDAQ-2010-141) (notice of filing and immediate effectiveness)(the ``ISP Filing''). See also Securities Exchange Act Release Nos. 63414 (December 2, 2010), 75 FR 76505..., 2011), 76 FR 1201 (January 7, 2011)(NASDAQ-2010-154) (notice of filing and immediate effectiveness)....

  19. 76 FR 74103 - Self-Regulatory Organizations; National Stock Exchange, Inc.; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-30

    ... No. 62252 (June 10, 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS- 2010-014; SR-EDGA-2010-01... Exchange Act Release No. 62251 (June 10, 2010), 75 FR 34183 (June 16, 2010) (SR-FINRA-2010-025). \\4\\ The... (September 10, 2010), 75 FR 56618 (September 16, 2010) (File Nos. SR-BATS-2010-018; SR-BX-2010-044;...

  20. Sustained hypertension despite endothelial-specific eNOS rescue in eNOS-deficient mice.

    PubMed

    Suvorava, Tatsiana; Stegbauer, Johannes; Thieme, Manuel; Pick, Stephanie; Friedrich, Sebastian; Rump, Lars C; Hohlfeld, Thomas; Kojda, Georg

    2015-03-13

    The aim of the study was to evaluate the possible contribution of non-endothelial eNOS to the regulation of blood pressure (BP). To accomplish this, a double transgenic strain expressing eNOS exclusively in the vascular endothelium (eNOS-Tg/KO) has been generated by endothelial-specific targeting of bovine eNOS in eNOS-deficient mice (eNOS-KO). Expression of eNOS was evaluated in aorta, myocardium, kidney, brain stem and skeletal muscle. Organ bath studies revealed a complete normalization of aortic reactivity to acetylcholine, phenylephrine and the NO-donors in eNOS-Tg/KO. Function of eNOS in resistance arteries was demonstrated by acute i.v. infusion of acetylcholine and the NOS-inhibitor L-NAME. Acetylcholine decreased mean arterial pressure in all strains but eNOS-KO responded significantly less sensitive as compared eNOS-Tg/KO and C57BL/6. Likewise, acute i.v. L-NAME application elevated mean arterial pressure in C57BL/6 and eNOS-Tg/KO, but not in eNOS-KO. In striking contrast to these findings, mean, systolic and diastolic BP in eNOS-Tg/KO remained significantly elevated and was similar to values of eNOS-KO. Chronic oral treatment with L-NAME increased BP to the level of eNOS-KO only in C57BL/6, but had no effect on hypertension in eNOS-KO and eNOS-Tg/KO. Taken together, functional reconstitution of eNOS in the vasculature of eNOS-KO not even partially lowered BP. These data suggest that the activity of eNOS expressed in non-vascular tissue might play a role in physiologic BP regulation. PMID:25680465

  1. 76 FR 51094 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Notice of Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ... trade break unless that trade exceeded three, five or ten percent beyond the price that triggered the... Release Nos. 62252 (June 10, 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS-2010-014; SR-EDGA- 2010... 10, 2010), 75 FR 34183 (June 16, 2010) (SR-FINRA-2010- 025). \\7\\ See e.g., Securities Exchange...

  2. A Maillard reaction product enhances eNOS activity in human endothelial cells.

    PubMed

    Schmitt, Christoph A; Heiss, Elke H; Schachner, Daniel; Aristei, Yasmin; Severin, Theodor; Dirsch, Verena M

    2010-07-01

    Nitric oxide (NO) produced by the endothelial nitric oxide synthase (eNOS) is an important signaling molecule in the cardiovascular system. Although dietary factors can modulate eNOS activity, putative effects of processed food are barely investigated. We aimed to examine whether the model Maillard reaction product 3-hydroxy-2-methyl-1-propyl-4(1H)-pyridone (HMPP), formed from maltol or starch and propylamine, affects the eNOS system. Incubation of EA.hy926 endothelial cells with 30-300 microM HMPP for 18 h enhanced endothelial NO release measured with the fluorescent probe diaminofluorescein-2 and eNOS activity determined by the [14C]L-arginine-[14C]L-citrulline conversion assay. HMPP increased NO production also in two different types of primary human endothelial cells. Protein levels of eNOS and inducible NO synthase remained unaltered by HMPP. HMPP inhibited eNOS activity within the first 2-4 h, whereas it potently increased eNOS activity after 12-24 h. Levels of eNOS phosphorylation, expression of heat-shock protein 90, caveolin-1 and various antioxidant enzymes were not affected. Intracellular reactive oxygen species remained unchanged by HMPP. This is the first study to demonstrate positive effects of a Maillard reaction product on eNOS activity and endothelial NO production, which is considered favourable for cardiovascular protection. PMID:20112298

  3. Compress Your Files

    ERIC Educational Resources Information Center

    Branzburg, Jeffrey

    2005-01-01

    File compression enables data to be squeezed together, greatly reducing file size. Why would someone want to do this? Reducing file size enables the sending and receiving of files over the Internet more quickly, the ability to store more files on the hard drive, and the ability pack many related files into one archive (for example, all files…

  4. Rapid NOS-1-derived nitric oxide and peroxynitrite formation act as signaling agents for inducible NOS-2 expression in vascular smooth muscle cells.

    PubMed

    Scheschowitsch, Karin; de Moraes, João Alfredo; Sordi, Regina; Barja-Fidalgo, Christina; Assreuy, Jamil

    2015-10-01

    Septic vascular dysfunction is characterized by hypotension and hyporeactivity to vasoconstrictors and nitric oxide (NO), reactive oxygen species and peroxynitrite have a prominent role in this condition. However, the mechanism whereby the vascular dysfunction is initiated is poorly understood. Based on previous studies of our group and the literature,we hypothesize that constitutive nitric oxide synthases (c-NOS) and peroxynitrite may play a role in the development of septic vascular dysfunction. Bacterial lipopolysaccharide (LPS) and interferon-γ (IFN) were used to stimulate rat aorta smooth muscle cells (A7r5) and rat aorta slices. This stimulation led to a rapid (within minutes) production of NO and superoxide anion, which led to peroxynitrite formation. When this rapid initial burst was reduced, through the inhibition of c-NOS and NADPH oxidases (NOX) or the scavenging of NO and superoxide the NF-κB activation, NOS-2 expression and nitrite production were significantly attenuated. Although vascular smooth muscle cells express both c-NOS isoforms, gene knockdown revealed that only NOS-1-dependent NO and peroxynitrite formation are important for the later NOS-2 expression. Similar findings were obtained by knockdown NOX-1 gene, one source of superoxide for peroxynitrite formation. Taking together, we show that smooth muscle cell activation by LPS/IFN leads to a rapid formation of NOS-1-derived NO and NOX-1-derived superoxide, forming peroxynitrite; and that this species act as a trigger for NOS-2 expression through NF-κB activation. Therefore, our findings suggest a critical role for NOS-1 and NOX-1 in the initiation of the vascular dysfunction associated with sepsis and septic shock.

  5. Reversal of SIN-1-induced eNOS dysfunction by the spin trap, DMPO, in bovine aortic endothelial cells via eNOS phosphorylation

    PubMed Central

    Das, Amlan; Gopalakrishnan, Bhavani; Druhan, Lawrence J; Wang, Tse-Yao; De Pascali, Francesco; Rockenbauer, Antal; Racoma, Ira; Varadharaj, Saradhadevi; Zweier, Jay L; Cardounel, Arturo J; Villamena, Frederick A

    2014-01-01

    Background and Purpose Nitric oxide (NO) derived from eNOS is mostly responsible for the maintenance of vascular homeostasis and its decreased bioavailability is characteristic of reactive oxygen species (ROS)-induced endothelial dysfunction (ED). Because 5,5-dimethyl-1-pyrroline-N-oxide (DMPO), a commonly used spin trap, can control intracellular nitroso-redox balance by scavenging ROS and donating NO, it was employed as a cardioprotective agent against ED but the mechanism of its protection is still not clear. This study elucidated the mechanism of protection by DMPO against SIN-1-induced oxidative injury to bovine aortic endothelial cells (BAEC). Experimental Approach BAEC were treated with SIN-1, as a source of peroxynitrite anion (ONOO−), and then incubated with DMPO. Cytotoxicity following SIN-1 alone and cytoprotection by adding DMPO was assessed by MTT assay. Levels of ROS and NO generation from HEK293 cells transfected with wild-type and mutant eNOS cDNAs, tetrahydrobiopterin bioavailability, eNOS activity, eNOS and Akt kinase phosphorylation were measured. Key Results Post-treatment of cells with DMPO attenuated SIN-1-mediated cytotoxicity and ROS generation, restoration of NO levels via increased in eNOS activity and phospho-eNOS levels. Treatment with DMPO alone significantly increased NO levels and induced phosphorylation of eNOS Ser1179 via Akt kinase. Transfection studies with wild-type and mutant human eNOS confirmed the dual role of eNOS as a producer of superoxide anion (O2−) with SIN-1 treatment, and a producer of NO in the presence of DMPO. Conclusion and Implications Post-treatment with DMPO of oxidatively challenged cells reversed eNOS dysfunction and could have pharmacological implications in the treatment of cardiovascular diseases. PMID:24405159

  6. 78 FR 17741 - Self-Regulatory Organizations; BOX Options Exchange LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-22

    ... Release No. 68771 (January 30, 2013), 78 FR 8208 (February 5, 2013) (Notice of Filing and Immediate... Exchange Act Release Nos. 66871 (April 27, 2012) 77 FR 26323 (May 3, 2012) (File No.10- 206, In the Matter... Findings, Opinion, and Order of the Commission), and 67328 (June 29, 2012) 77 FR 40123 (July 6, 2012)...

  7. 78 FR 38416 - Self-Regulatory Organizations; Miami International Securities Exchange LLC; Notice of Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-26

    ... Release Nos. 67754 (August 29, 2012), 77 FR 54629 (September 5, 2012) (Order approving SR-ISE-2012- 33) (``ISE filing''); 69633 (May 23, 2012), 78 FR 32498 (May 30, 2013) (SR-Phlx-2013-55) (``PHLX filing''); 68074 (October 19, 2012), 77 FR 65241 (October 25, 2012) (SR-CBOE-2012-92); and 68193 (November 8,...

  8. 78 FR 57191 - Self-Regulatory Organizations; BOX Options Exchange LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-17

    ... restrictions. \\5\\ See Securities Exchange Act Release Nos. 66278 (January 30, 2012), 77 FR 5590 (February 3... on a pilot basis (SR-BX-2011-046), 66979 (May 14, 2012), 77 FR 29740 (May 18, 2012) (Notice of Filing...) (SR-BOX-2012-002), and 69054 (March 7, 2013), 78 FR 16025(March 13, 2013) (Notice of Filing...

  9. 78 FR 75644 - Self-Regulatory Organizations; BOX Options Exchange LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-12

    ... Exchange Act Release Nos. 70472 (September 23, 2013), 78 FR 59738 (September 27, 2013)(Notice of Filing and Immediate Effectiveness of SR-PHLX-2013-93); 70470 (September 23, 2013) 78 FR 59740 (September 27, 2013)(Notice of Filing and Immediate Effectiveness of SR-NASDAQ-2013-117); and 70657 (October 10, 2013), 78...

  10. The return of the Scarlet Pimpernel: cobalamin in inflammation II - cobalamins can both selectively promote all three nitric oxide synthases (NOS), particularly iNOS and eNOS, and, as needed, selectively inhibit iNOS and nNOS.

    PubMed

    Wheatley, Carmen

    2007-09-01

    The up-regulation of transcobalamins [hitherto posited as indicating a central need for cobalamin (Cbl) in inflammation], whose expression, like inducible nitric oxide synthase (iNOS), is Sp1- and interferondependent, together with increased intracellular formation of glutathionylcobalamin (GSCbl), adenosylcobalamin (AdoCbl), methylcobalamin (MeCbl), may be essential for the timely promotion and later selective inhibition of iNOS and concordant regulation of endothelial and neuronal NOS (eNOS/nNOS.) Cbl may ensure controlled high output of nitric oxide (NO) and its safe deployment, because: (1) Cbl is ultimately responsible for the synthesis or availability of the NOS substrates and cofactors heme, arginine, BH(4) flavin adenine dinucleotide/flavin mononucleotide (FAD/FMN) and NADPH, via the far-reaching effects of the two Cbl coenzymes, methionine synthase (MS) and methylmalonyl CoA mutase (MCoAM) in, or on, the folate, glutathione, tricarboxylic acid (TCA) and urea cycles, oxidative phosphorylation, glycolysis and the pentose phosphate pathway. Deficiency of any of theNOS substrates and cofactors results in 'uncoupled' NOS reactions, decreasedNO production and increased or excessive O(2) (-), H(2)O(2), ONOO(-) and other reactive oxygen species (ROS), reactive nitric oxide species (RNIS) leading to pathology. (2) Cbl is also the overlooked ultimate determinant of positive glutathione status, which favours the formation of more benign NO species, s-nitrosothiols, the predominant form in which NO is safely deployed. Cbl status may consequently act as a 'back-up disc' that ensures the active status of antioxidant systems, as well as reversing and modulating the effects of nitrosylation in cell signal transduction.New evidence shows that GSCbl can significantly promote iNOS/ eNOS NO synthesis in the early stages of inflammation, thus lowering high levels of tumour necrosis factor-a that normally result in pathology, while existing evidence shows that in extreme

  11. The return of the Scarlet Pimpernel: cobalamin in inflammation II — cobalamins can both selectively promote all three nitric oxide synthases (NOS), particularly iNOS and eNOS, and, as needed, selectively inhibit iNOS and nNOS

    PubMed Central

    Wheatley, Carmen

    2007-01-01

    The up-regulation of transcobalamins [hitherto posited as indicating a central need for cobalamin (Cbl) in inflammation], whose expression, like inducible nitric oxide synthase (iNOS), is Sp1- and interferondependent, together with increased intracellular formation of glutathionylcobalamin (GSCbl), adenosylcobalamin (AdoCbl), methylcobalamin (MeCbl), may be essential for the timely promotion and later selective inhibition of iNOS and concordant regulation of endothelial and neuronal NOS (eNOS/nNOS.) Cbl may ensure controlled high output of nitric oxide (NO) and its safe deployment, because: (1) Cbl is ultimately responsible for the synthesis or availability of the NOS substrates and cofactors heme, arginine, BH4 flavin adenine dinucleotide/flavin mononucleotide (FAD/FMN) and NADPH, via the far-reaching effects of the two Cbl coenzymes, methionine synthase (MS) and methylmalonyl CoA mutase (MCoAM) in, or on, the folate, glutathione, tricarboxylic acid (TCA) and urea cycles, oxidative phosphorylation, glycolysis and the pentose phosphate pathway. Deficiency of any of theNOS substrates and cofactors results in ‘uncoupled’ NOS reactions, decreasedNO production and increased or excessive O2−, H2O2, ONOO− and other reactive oxygen species (ROS), reactive nitric oxide species (RNIS) leading to pathology. (2) Cbl is also the overlooked ultimate determinant of positive glutathione status, which favours the formation of more benign NO species, s-nitrosothiols, the predominant form in which NO is safely deployed. Cbl status may consequently act as a ‘back-up disc’ that ensures the active status of antioxidant systems, as well as reversing and modulating the effects of nitrosylation in cell signal transduction.New evidence shows that GSCbl can significantly promote iNOS/ eNOS NO synthesis in the early stages of inflammation, thus lowering high levels of tumour necrosis factor-a that normally result in pathology, while existing evidence shows that in extreme

  12. 78 FR 66336 - Marine Mammals; File No. 17030

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-05

    ... National Oceanic and Atmospheric Administration RIN 0648-XC956 Marine Mammals; File No. 17030 AGENCY... Permits for Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No... submitted by facsimile to (301)713-0376, or by email to NMFS.Pr1Comments@noaa.gov . Please include File...

  13. 75 FR 39915 - Marine Mammals; File No. 15483

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-13

    ... National Oceanic and Atmospheric Administration RIN 0648-XX23 Marine Mammals; File No. 15483 AGENCY... Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No. 15483 from the... include the File No. in the subject line of the email comment. Those individuals requesting a...

  14. 76 FR 18533 - Marine Mammals; File No. 15682

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-04

    ... National Oceanic and Atmospheric Administration RIN 0648-XA342 Marine Mammals; File No. 15682 AGENCY... Permits for Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No... include the File No. in the subject line of the e-mail comment. Those individuals requesting a...

  15. Morphological and genetic variation in North Atlantic giant file clams, Acesta spp. (Bivalvia: Limidae), with description of a new cryptic species in the northwest Atlantic.

    PubMed

    Gagnon, Jean-Marc; Kenchington, Ellen; Port, Antony; Anstey, Lynne J; Murillo, Francisco Javier

    2015-01-01

    We analyze the morphological and genetic variability within and between seven species of Acesta and specimens recently collected in the northwest Atlantic using traditional morphological measurements, landmark-based geometric morphometrics, and the cytochrome oxidase subunit I (COI) gene sequences, with particular emphasis on North Atlantic species. Shell morphology and external shell appearance do not allow reliable distinction between the widely recognized northeastern Atlantic A. excavata and other northwest Atlantic species or populations of Acesta, with the exception of A. oophaga. Similarly, shape analysis reveals a wide variability within northeastern Atlantic A. excavata, and significant morphological overlap with A. bullisi from the Gulf of Mexico and A. rathbuni from the southwestern Pacific and South China Sea. Specimens from the northwestern and Mid-Atlantic display shell shapes marginally similar to that of A. excavata. These differences are at least partly related to anterior or posterior shifting of the shell body and to the opposite shifting of the hinge line/dorsal region and upper lunule. These morphological variations, along with the midline-width-ratio, explain much of the variability extracted by principal component analysis. Results from a mitochondrial DNA barcode approach (COI), however, suggest that the northwest Atlantic specimens belong to a new species for which we propose the name Acesta cryptadelphe sp. nov. Differences in larval shell sizes between northeastern and northwestern Atlantic specimens are consistent with this result.

  16. 76 FR 77222 - Combined Notice of Filings #2

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-12

    ... Corporation, FirstLight Power Resources Management, L,GDF SUEZ Energy Marketing NA, Inc., Green Mountain Power... Agreement Nos. 3156 and 3157-PJM Queue X2-082 to be effective 11/4/2011. Filed Date: 12/5/11. Accession.... Applicants: PJM Interconnection, L.L.C. Description: Original Service Agreement No. 3153; Queue No. W1-029...

  17. 77 FR 73027 - Combined Notice of Filings #2

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    2012-12-07

    ... Queue Nos. T167/Y1-048/Y1-066; First Revised SA 2442 to be effective 10/31/2012. Filed Date: 11/30/12... Commission's eLibrary system by clicking on the links or querying the docket number. Any person desiring...

  18. 75 FR 70229 - Combined Notice of Filings No. 2

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-17

    ..., November 17, 2010. Docket Numbers: RP10-1037-001. Applicants: Granite State Gas Transmission, Inc. Description: Granite State Gas Transmission, Inc. Filing Addressing Compliance Obligations in Docket Nos. RP10..., 2010. Docket Numbers: RP10-963-002. Applicants: Granite State Gas Transmission, Inc....

  19. 76 FR 51105 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

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    2011-08-17

    ..., 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS-2010-014; SR- EDGA-2010-01; SR-EDGX-2010-01; SR...- 2010-061; SR-CHX-2010-10; SR-NSX-2010-05; and SR-CBOE-2010-047) and 62251 (June 10, 2010), 75 FR 34183... (September 10, 2010), 75 FR 56618 (September 16, 2010) (File Nos. SR-BATS-2010-018; SR-BX-2010-044;...

  20. 76 FR 51092 - Self-Regulatory Organizations; BATS Y-Exchange, Inc.; Notice of Filing of Proposed Rule Change To...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ... FR 34186 (June 16, 2010)(File Nos. SR-BATS-2010-014; SR-EDGA- 2010-01; SR-EDGX-2010-01; SR-BX-2010...- 061; SR-CHX-2010-10; SR-NSX-2010-05; and SR-CBOE-2010-047); 62251 (June 10, 2010), 75 FR 34183 (June... 10, 2010), 75 FR 56618 (September 16, 2010) (File Nos. SR-BATS-2010-018; SR-BX-2010-044;...

  1. 76 FR 27678 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing of Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-12

    ... Release No. 62252 (June 10, 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS-2010-014; SR-EDGA-2010... Securities Exchange Act Release No. 62251 (June 10, 2010), 75 FR 34183 (June 16, 2010) (SR-FINRA-2010-025... Release No. 62884 (September 10, 2010), 75 FR 56618 (September 16, 2010) (File Nos. SR-BATS-2010-018;...

  2. 76 FR 27704 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing of Proposed Rule Change To...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-12

    ...), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS-2010-014; SR-EDGA-2010-01; SR-EDGX-2010-01; SR-BX-2010... (June 10, 2010), 75 FR 34183 (June 16, 2010) (SR-FINRA-2010-025). \\4\\ The Commission approved the..., 2010), 75 FR 56618 (September 16, 2010) (File Nos. SR-BATS-2010-018; SR-BX-2010-044;...

  3. 76 FR 74080 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

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    2011-11-30

    ...), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS- 2010-014; SR-EDGA-2010-01; SR-EDGX-2010-01; SR-BX.... 62251 (June 10, 2010), 75 FR 34183 (June 16, 2010) (SR-FINRA-2010-025). \\5\\ The Commission approved the...), 75 FR 56618 (September 16, 2010) (File Nos. SR-BATS-2010-018; SR-BX-2010-044; SR-CBOE-2010-065;...

  4. 76 FR 74099 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-30

    ...), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS- 2010-014; SR-EDGA-2010-01; SR-EDGX-2010-01; SR-BX.... 62251 (June 10, 2010), 75 FR 34183 (June 16, 2010) (SR-FINRA-2010-025). \\5\\ The Commission approved the...), 75 FR 56618 (September 16, 2010) (File Nos. SR-BATS-2010-018; SR-BX-2010-044; SR-CBOE-2010-065;...

  5. Common File Formats.

    PubMed

    Mills, Lauren

    2014-03-21

    An overview of the many file formats commonly used in bioinformatics and genome sequence analysis is presented, including various data file formats, alignment file formats, and annotation file formats. Example workflows illustrate how some of the different file types are typically used.

  6. Role of muscular eNOS in skeletal arteries: Endothelium-independent hypoxic vasoconstriction of the femoral artery is impaired in eNOS-deficient mice.

    PubMed

    Kim, Hae Jin; Yoo, Hae Young; Lin, Hai Yue; Oh, Goo Taeg; Zhang, Yin Hua; Kim, Sung Joon

    2016-09-01

    We previously reported that hypoxia augments α-adrenergic contraction (hypoxic vasoconstriction, HVC) of skeletal arteries in rats. The underlying mechanism may involve hypoxic inhibition of endothelial nitric oxide synthase (eNOS) expressed in skeletal arterial myocytes (16). To further explore the novel role of muscular eNOS in the skeletal artery, we compared HVC in femoral arteries (FAs) from eNOS knockout (KO) mice with that from wild-type (WT) and heterozygous (HZ) mice. Immunohistochemical assays revealed that, in addition to endothelia, eNOS is also expressed in the medial layer of FAs, albeit at a much lower level. However, the medial eNOS signal was not evident in HZ FAs, despite strong expression in the endothelium; similar observations were made in WT carotid arteries (CAs). The amplitude of contraction induced by 1 μM phenylephrine (PhE) was greater in HZ than in WT FAs. Hypoxia (3% Po2) significantly augmented PhE-induced contraction in WT FAs but not in HZ or KO FAs. No HVC was observed in PhE-pretreated WT CAs. The NOS inhibitor nitro-l-arginine methyl ester (0.1 mM) also augmented PhE contraction in endothelium-denuded WT FAs but not in WT CAs. Inhibitors specific to neuronal NOS and inducible NOS did not augment PhE-induced contraction of WT FAs. NADPH oxidase 4 (NOX4) inhibitor (GKT137831, 5 μM), but not NOX2 inhibitor (apocynin, 100 μM), suppressed HVC. Consistent with the role of reactive oxygen species (ROS), HVC was also inhibited by pretreatment with tiron or polyethylene glycol-catalase. Taken together, these data suggest that the eNOS expressed in smooth muscle cells in FAs attenuates α-adrenergic vasoconstriction; this suppression is alleviated under hypoxia, which potentiates vasoconstriction in a NOX4/ROS-dependent mechanism. PMID:27486092

  7. 76 FR 51108 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ... trade exceeded three, five or ten percent beyond the price that triggered the pause. This scenario... Release Nos. 62252 (June 10, 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS-2010-014; SR-EDGA- 2010... 10, 2010), 75 FR 34183 (June 16, 2010) (SR-FINRA-2010-025). \\5\\ See e.g., Securities Exchange...

  8. Case File: The Spazzoids

    MedlinePlus

    ... classroom activities. More Related Links Healthy Schools Case file: The Spazzzoids Recommend on Facebook Tweet Share Compartir ... your classroom activities. More Related Links Healthy Schools File Formats Help: How do I view different file ...

  9. Lawsuit filed.

    PubMed

    1996-04-19

    Social service providers at a Boston center for Haitian immigrants filed a suit in a U.S. District Court against the Federal government. The suit claims that auditors from the Inspector General's Office in the U.S. Department of Health and Human Services demanded the names of clients with AIDS. The auditors explained that this process, conducted to determine whether agencies are properly spending Ryan White CARE Act funds, is appropriate and routine. Attorneys for the social service providers contend that the actions of the auditors breached client confidentiality and privacy.

  10. Bioinformatic comparisons and tissue expression of the neuronal nitric oxide synthase (nNOS) gene from the red drum (Sciaenops ocellatus).

    PubMed

    Zhou, Libin; Bai, Ru; Tian, Jianxiao; Liu, Xiaochun; Lu, Danqi; Zhu, Pei; Liu, Yun; Zeng, Lujiao; Luo, Wenna; Zhang, Yong; Wang, Anli

    2009-10-01

    The full length cDNA sequence for neuronal nitric oxide synthase (nNOS) gene from red drum (Sciaenops ocellatus) has been cloned, subjected to bioinformatic analysis, and examined for expression in different tissues. Red drum nNOS showed high identity to nNOS of mammals and other fish species. Notably, a unique 7-aa insertion was found in the important catalytic sites of the NO synthase domain, possibly affecting the function of red drum nNOS. Furthermore, this nNOS was expressed not only in brain but also in most of the internal organs including liver, intestine, spleen, head kidney and thymus. PMID:19647082

  11. 43 CFR 4.1352 - Who may file; where to file; when to file.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Who may file; where to file; when to file... Indian Lands) § 4.1352 Who may file; where to file; when to file. (a) The applicant or operator may file... to file a timely request constitutes a waiver of the opportunity for a hearing before OSM makes...

  12. C. pneumoniae disrupts eNOS trafficking and impairs NO production in human aortic endothelial cells.

    PubMed

    Mueller, Konrad E; Wolf, Katerina

    2015-01-01

    Endothelial nitric oxide synthase (eNOS) generated NO plays a crucial physiological role in the regulation of vascular tone. eNOS is a constitutively expressed synthase whose enzymatic function is regulated by dual acylation, phosphorylation, protein-protein interaction and subcellular localization. In endothelial cells, the enzyme is primarily localized to the Golgi apparatus (GA) and the plasma membrane where it binds to caveolin-1. Upon stimulation, the enzyme is translocated from the plasma membrane to the cytoplasm where it generates NO. When activation of eNOS ceases, the majority of the enzyme is recycled back to the membrane fraction. An inability of eNOS to cycle between the cytosol and the membrane leads to impaired NO production and vascular dysfunction. Chlamydia pneumoniae is a Gram-negative obligate intracellular bacterium that primarily infects epithelial cells of the human respiratory tract, but unlike any other chlamydial species, C. pneumoniae displays tropism toward atherosclerotic tissues. In this study, we demonstrate that C. pneumoniae inclusions colocalize with eNOS, and the microorganism interferes with trafficking of the enzyme from the GA to the plasma membrane in primary human aortic endothelial cells. This mislocation of eNOS results in significant inhibition of NO release by C. pneumoniae-infected cells. Furthermore, we show that the distribution of eNOS in C. pneumoniae-infected cells is altered due to an intimate association of the Golgi complex with chlamydial inclusions rather than by direct interaction of the enzyme with the chlamydial inclusion membrane.

  13. The role of eNOS phosphorylation in causing drug-induced vascular injury.

    PubMed

    Tobin, Grainne A McMahon; Zhang, Jun; Goodwin, David; Stewart, Sharron; Xu, Lin; Knapton, Alan; González, Carlos; Bancos, Simona; Zhang, Leshuai; Lawton, Michael P; Enerson, Bradley E; Weaver, James L

    2014-06-01

    Previously we found that regulation of eNOS is an important part of the pathogenic process of Drug-induced vascular injury (DIVI) for PDE4i. The aims of the current study were to examine the phosphorylation of eNOS in mesentery versus aorta at known regulatory sites across DIVI-inducing drug classes and to compare changes across species. We found that phosphorylation at S615 in rats was elevated 35-fold 2 hr after the last dose of CI-1044 in mesentery versus 3-fold in aorta. Immunoprecipitation studies revealed that many of the upstream regulators of eNOS activation were associated with eNOS in 1 or more signalosome complexes. Next rats were treated with drugs from 4 other classes known to cause DIVI. Each drug was given alone and in combination with SIN-1 (NO donor) or L-NAME (eNOS inhibitor), and the level of eNOS phosphorylation in mesentery and aorta tissue was correlated with the extent of vascular injury and measured serum nitrite. Drugs or combinations produced altered serum nitrite levels as well as vascular injury score in the mesentery. The results suggested that phosphorylation of S615 may be associated with DIVI activity. Studies with the species-specific A2A adenosine agonist CI-947 in rats versus primates showed a similar pattern.

  14. 78 FR 17985 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-25

    ...), 78 FR 6382 (January 30, 2013) (SR-NASDAQ-2013-011) (notice of filing and immediate effectiveness of.... See Securities Exchange Act Release Nos. 57579 (March 28, 2008), 73 FR 18587 (April 4, 2008)(SR-NASDAQ... 21, 2012), 78 FR 136 (January 2, 2013) (SR-NASDAQ-2012-143) (notice of filing and...

  15. 76 FR 45629 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-29

    ... qualification examination, the Series 56, was recently filed with the Commission; \\6\\ NASDAQ expects to file the... new examination, the Series 56. \\5\\ See Securities Exchange Act Release Nos. 63843 (February 4, 2011), 76 FR 7884 (February 11, 2011) (SR-ISE-2010-115); and 63314 (November 12, 2010), 75 FR...

  16. 78 FR 48744 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    ... standard (monthly) option. \\4\\ See Securities Exchange Act Release Nos. 68460 (December 18, 2012), 77 FR... 18, 2012), 77 FR 76155 (December 26, 2012) (SR-NYSEArca-2012-94) (approval order) (``NYSE Arca filing''); 68606 (January 9, 2013), 78 FR 3065 (January 15, 2013) (SR-CBOE-2012-131) (notice of filing...

  17. 78 FR 48734 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    ...\\ See Securities Exchange Act Release Nos. 68460 (December 18, 2012), 77 FR 76145 (December 26, 2012) (SR-NYSEMKT-2012-41) (approval order) (``NYSE MKT filing''); 68461 (December 18, 2012), 77 FR 76155...), 78 FR 3065 (January 15, 2013) (SR-CBOE-2012-131) (notice of filing and immediate...

  18. 76 FR 74082 - Self-Regulatory Organizations; NYSE Amex LLC; Notice of Filing and Immediate Effectiveness of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-30

    ... Securities Exchange Act Release No. 62252 (June 10, 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS...- 2010-047) and Securities Exchange Act Release No. 62251 (June 10, 2010), 75 FR 34183 (June 16, 2010... Securities Exchange Act Release No. 62884 (September 10, 2010), 75 FR 56618 (September 16, 2010) (File...

  19. 76 FR 13694 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-14

    ... are executed in dark pools. Securities Exchange Act Release No. 61358 (January 14, 2010), 75 FR 3594... FR 69489 (November 12, 2010) (NASDAQ-2010-141) (notice of filing and immediate effectiveness) (the ``ISP Filing''). See also Securities Exchange Act Release Nos. 63414 (December 2, 2010), 75 FR...

  20. 76 FR 70784 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-15

    ... as originally implemented, see Securities Exchange Act Release No. 63270 (November 8, 2010), 75 FR... Filing''). See also Securities Exchange Act Release Nos. 63414 (December 2, 2010), 75 FR 76505 (December...), 76 FR 1201 (January 7, 2011) (NASDAQ-2010-154) (notice of filing and immediate effectiveness);...

  1. 78 FR 41176 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-09

    ... Exchange Act Release Nos. 68460 (December 18, 2012), 77 FR 76145 (December 26, 2012) (SR-NYSEMKT-2012-41) (approval order) (``NYSE MKT filing''); 68461 (December 18, 2012), 77 FR 76155 (December 26, 2012) (SR-NYSEArca-2012-94) (approval order) (``NYSE Arca filing''); and 68606 (January 9, 2013), 78 FR 3065...

  2. 77 FR 40126 - Self-Regulatory Organizations; NASDAQ OMX Phlx, LLC; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-06

    ... Release Nos. 55153 (January 23, 2007), 72 FR 4553 (January 31, 2007) (SR-Phlx-2006-74) (notice of filing and approval order establishing Penny Pilot); 60873 (October 23, 2009), 74 FR 56675 (November 2, 2009...); 60966 (November 9, 2009), 74 FR 59331 (November 17, 2009) (SR-Phlx-2009-94) (notice of filing...

  3. Report filing in histopathology.

    PubMed Central

    Blenkinsopp, W K

    1977-01-01

    An assessment of alternative methods of filing histopathology report forms in alphabetical order showed that orthodox card index filing is satisfactory up to about 100000 reports but, because of the need for long-term retrieval, when the reports filed exceed this number they should be copied on jacketed microfilm and a new card index file begun. PMID:591645

  4. Common file formats.

    PubMed

    Leonard, Shonda A; Littlejohn, Timothy G; Baxevanis, Andreas D

    2007-01-01

    This appendix discusses a few of the file formats frequently encountered in bioinformatics. Specifically, it reviews the rules for generating FASTA files and provides guidance for interpreting NCBI descriptor lines, commonly found in FASTA files. In addition, it reviews the construction of GenBank, Phylip, MSF and Nexus files. PMID:18428774

  5. Multifaceted NOS Instruction: Contextualizing Nature of Science with Documentary Films

    ERIC Educational Resources Information Center

    Bloom, Mark; Binns, Ian C.; Koehler, Catherine

    2015-01-01

    This research focuses on inservice science teachers' conceptions of nature of science (NOS) before and after a two-week intensive summer professional development (PD). The PD combined traditional explicit NOS instruction, numerous interactive interventions that highlighted NOS aspects, along with documentary films that portrayed NOS in context of…

  6. Disrupted NOS signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow.

    PubMed

    Datar, Sanjeev A; Gong, Wenhui; He, Youping; Johengen, Michael; Kameny, Rebecca J; Raff, Gary W; Maltepe, Emin; Oishi, Peter E; Fineman, Jeffrey R

    2016-07-01

    Associated abnormalities of the lymphatic circulation are well described in congenital heart disease. However, their mechanisms remain poorly elucidated. Using a clinically relevant ovine model of a congenital cardiac defect with chronically increased pulmonary blood flow (shunt), we previously demonstrated that exposure to chronically elevated pulmonary lymph flow is associated with: 1) decreased bioavailable nitric oxide (NO) in pulmonary lymph; and 2) attenuated endothelium-dependent relaxation of thoracic duct rings, suggesting disrupted lymphatic endothelial NO signaling in shunt lambs. To further elucidate the mechanisms responsible for this altered NO signaling, primary lymphatic endothelial cells (LECs) were isolated from the efferent lymphatic of the caudal mediastinal node in 4-wk-old control and shunt lambs. We found that shunt LECs (n = 3) had decreased bioavailable NO and decreased endothelial nitric oxide synthase (eNOS) mRNA and protein expression compared with control LECs (n = 3). eNOS activity was also low in shunt LECs, but, interestingly, inducible nitric oxide synthase (iNOS) expression and activity were increased in shunt LECs, as were total cellular nitration, including eNOS-specific nitration, and accumulation of reactive oxygen species (ROS). Pharmacological inhibition of iNOS reduced ROS in shunt LECs to levels measured in control LECs. These data support the conclusion that NOS signaling is disrupted in the lymphatic endothelium of lambs exposed to chronically increased pulmonary blood and lymph flow and may contribute to decreased pulmonary lymphatic bioavailable NO.

  7. The Complex Role of iNOS in Acutely-Rejecting Cardiac Transplants

    PubMed Central

    Pieper, Galen M.; Roza, Allan M.

    2008-01-01

    This review summarizes the evidence for a detrimental role of nitric oxide (NO) derived from inducible NO synthase (iNOS) and/or reactive nitrogen species such as peroxynitrite in acutely-rejecting cardiac transplants. In chronic cardiac transplant rejection, iNOS may have an opposing beneficial component. The purpose of this review is primarily to address issues related to acute rejection which is a recognized risk factor for chronic rejection. The evidence for a detrimental role is based upon strategies involving non-selective NOS inhibitors, NO neutralizers, selective iNOS inhibitors and iNOS gene deletion in rodent models of cardiac rejection. The review is discussed in the context of the impact on various components including graft survival, histological rejection and cardiac function which may contribute in toto to the process of graft rejection. Possible limitations of each strategy are discussed in order to understand better the variance in published findings including issues related to the potential importance of cell localization of iNOS expression. Finally, the concept of a dual role of NO and its down-stream product, peroxynitrite, in rejection vs. immune regulation is discussed. PMID:18291116

  8. Text File Display Program

    NASA Technical Reports Server (NTRS)

    Vavrus, J. L.

    1986-01-01

    LOOK program permits user to examine text file in pseudorandom access manner. Program provides user with way of rapidly examining contents of ASCII text file. LOOK opens text file for input only and accesses it in blockwise fashion. Handles text formatting and displays text lines on screen. User moves forward or backward in file by any number of lines or blocks. Provides ability to "scroll" text at various speeds in forward or backward directions.

  9. Standard interface file handbook

    SciTech Connect

    Shapiro, A.; Huria, H.C. )

    1992-10-01

    This handbook documents many of the standard interface file formats that have been adopted by the US Department of Energy to facilitate communications between and portability of, various large reactor physics and radiation transport software packages. The emphasis is on those files needed for use of the VENTURE/PC diffusion-depletion code system. File structures, contents and some practical advice on use of the various files are provided.

  10. Text File Comparator

    NASA Technical Reports Server (NTRS)

    Kotler, R. S.

    1983-01-01

    File Comparator program IFCOMP, is text file comparator for IBM OS/VScompatable systems. IFCOMP accepts as input two text files and produces listing of differences in pseudo-update form. IFCOMP is very useful in monitoring changes made to software at the source code level.

  11. The Vertical File.

    ERIC Educational Resources Information Center

    Czopek, Vanessa

    The process of establishing the vertical file for a new branch library is traced; suggestions for making the vertical file a better resource are offered; and guidelines covering the general objective, responsibility for selection and maintenance, principles of selection, and scope of the collection for vertical files are presented. A four-item…

  12. 77 FR 27441 - Marine Mammals; File No. 13927

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-10

    ... (50 CFR parts 222-226). Permit No. 13927, issued on October 19, 2011 (76 FR 67151), authorizes the... National Oceanic and Atmospheric Administration RIN 0648-XA774 Marine Mammals; File No. 13927 AGENCY... Permits for Protected Species home page, https://apps.nmfs.noaa.gov , and then selecting File No....

  13. 77 FR 36999 - Marine Mammals; File No. 16160

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-20

    ... (77 FR 35657), authorizes takes of eight species of cetaceans in the inland waters of Washington State... National Oceanic and Atmospheric Administration RIN 0648-XA626 Marine Mammals; File No. 16160 AGENCY....nmfs.noaa.gov , and then selecting File No. 16160 from the list of available applications....

  14. 43 CFR 4.1381 - Who may file; when to file; where to file.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... may file; when to file; where to file. (a) Any person who receives a written decision issued by OSM under 30 CFR 773.28 on a challenge to an ownership or control listing or finding may file a request for... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Who may file; when to file; where to...

  15. Catalytic Promiscuity of the Radical S-adenosyl-L-methionine Enzyme NosL

    PubMed Central

    Ding, Wei; Ji, Xinjian; Li, Yongzhen; Zhang, Qi

    2016-01-01

    Catalytic promiscuity plays a key role in enzyme evolution and the acquisition of novel biological functions. Because of the high reactivity of radical species, in our view enzymes involving radical-mediated mechanisms could intrinsically be more prone to catalytic promiscuity. This mini-review summarizes the recent advances in the study of NosL, a radical S-adenosyl-L-methionine (SAM)-dependent L-tryptophan (L-Trp) lyase. We demonstrate here the interesting chemistry and remarkable catalytic promiscuity of NosL, and attempt to highlight the high evolvability of radical SAM enzymes and the potential to engineer these enzymes for novel and improved activities. PMID:27446906

  16. An evolutionarily ancient NO synthase (NOS) in shrimp.

    PubMed

    Wu, Chun-Hung; Siva, Vinu S; Song, Yen-Ling

    2013-11-01

    Nitric oxide (NO) is a well known essential molecule that is involved in multiple functions such as neuron transduction, cardiac disease, immune responses, etc.; nitric oxide synthase (NOS) is a critical enzyme that catalyzes the synthesis of it. A very few crustacean NOS molecules were biochemically characterized so far. In the present study, we cloned and characterized a NOS cDNA from haemocytes of tiger shrimp (Penaeus monodon) (PmNOS). The full-length of PmNOS cDNA contained 3997 bp, including a 5'UTR of 249 bp, ORF of 3582 bp and a 3'UTR of 166 bp. The putative peptide was 1193 amino acid residues in length, with an estimated molecular weight of 134.7 kDa and pI 6.7. Structurally, PmNOS contained oxygenase and reductase domains at N-terminal and C-terminal, respectively, and connected with a calmodulin binding motif. The deduced amino acid sequence of PmNOS shared 98% identical to the Chinese shrimp (Fenneropenaeus chinensis) NOS. Phylogenetically, PmNOS clustered with invertebrate NOS, but not clustered with iNOS, eNOS or nNOS found in vertebrates. PmNOS mRNA was expressed in many tissues or organs including thoracic and ventral nerves, midgut, gill, eyestalk, haemocytes, subcuticular epithelium and heart, but not found in hepatopancreas, muscle and lymphoid organ. But there was no significant difference in PmNOS mRNA expression after stimulation with LPS either by different concentration or time course or against CpG-ODN 2006. The enzyme activities of rPmNOS or crude homogenates from different tissues were detected, and were shown its highest activity in thoracic and ventral nerves, moderate in midgut and haemocytes but the lowest activity were seen in muscle. The addition of NOS antibody against NADPH binding domain leads to less activity which suggested that NADPH was an essential cofactor for PmNOS catalytic activity. The calcium dependency of PmNOS was ascertained using calmodulin inhibitor, Trifluroperazine. To confirm the population of haemocyte which

  17. The SPRY domain–containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation

    PubMed Central

    Kuang, Zhihe; Lewis, Rowena S.; Curtis, Joan M.; Zhan, Yifan; Saunders, Bernadette M.; Babon, Jeffrey J.; Kolesnik, Tatiana B.; Low, Andrew; Masters, Seth L.; Willson, Tracy A.; Kedzierski, Lukasz; Yao, Shenggen; Handman, Emanuela

    2010-01-01

    Inducible nitric oxide (NO) synthase (iNOS; NOS2) produces NO and related reactive nitrogen species, which are critical effectors of the innate host response and are required for the intracellular killing of pathogens such as Mycobacterium tuberculosis and Leishmania major. We have identified SPRY domain–containing SOCS (suppressor of cytokine signaling) box protein 2 (SPSB2) as a novel negative regulator that recruits an E3 ubiquitin ligase complex to polyubiquitinate iNOS, resulting in its proteasomal degradation. SPSB2 interacts with the N-terminal region of iNOS via a binding interface on SPSB2 that has been mapped by nuclear magnetic resonance spectroscopy and mutational analyses. SPSB2-deficient macrophages showed prolonged iNOS expression, resulting in a corresponding increase in NO production and enhanced killing of L. major parasites. These results lay the foundation for the development of small molecule inhibitors that could disrupt the SPSB–iNOS interaction and thus prolong the intracellular lifetime of iNOS, which may be beneficial in chronic and persistent infections. PMID:20603330

  18. Network file-storage system

    SciTech Connect

    Collins, W.W.; Devaney, M.J.; Willbanks, E.W.

    1982-01-01

    The Common File System (CFS) is a file management and mass storage system for the Los Alamos National Laboratory's computer network. The CFS is organized as a hierarchical storage system: active files are stored on fast-access storage devices, larger, less active files are stored on slower, less expensive devices, and archival files are stored offline. Files are automatically moved between the various classes of storage by a file migration program that analyzes file activity, file size and storage device capabilities. This has resulted in a cost-effective system that provides both fast access and large data storage capability (over five trillion bits currently stored).

  19. 75 FR 44037 - Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-27

    ..., 2010. See Securities Exchange Act Release Nos. 57579 (March 28, 2008), 73 FR 18587 (April 4, 2008) (SR... 23, 2009), 74 FR 56682 (November 2, 2009) (SR-NASDAQ-2009-091) (notice of filing and immediate effectiveness expanding and extending Penny Pilot); 60965 (November 9, 2009), 74 FR 59292 (November 17,...

  20. 77 FR 65241 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Notice of Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-25

    ... non-Weekly options expire. \\6\\ See Securities Exchange Act Release Nos. 67754 (August 29, 2012), 77 FR...) 77 FR 54635 (September 5, 2012) (order approving SR-Phlx-2012-78) (``Phlx filing''). ISE and Phlx... Exchange is making a distinction between initiating series and cloning series. The Exchange and...

  1. 76 FR 19160 - Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-06

    .... \\3\\ See Securities Exchange Act Release No. 35993 (July 19, 1995), 60 FR 38073 (July 25, 1995... also Exchange Act Release No. 52893 (December 5, 2005) 70 FR 73488 (December 12, 2005) (a rule change... Exchange Act Release No. 40662 (November 12, 1998), 63 FR 64297 (November 19, 1998) (approving File Nos....

  2. 76 FR 19165 - Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-06

    .... \\3\\ See Securities Exchange Act Release No. 35993 (July 19, 1995), 60 FR 38073 (July 25, 1995... Exchange Act Release No. 52986 (December 20, 2005) 70 FR 76897 (December 28, 2005) (a rule change to allow... Exchange Act Release No. 40662 (November 12, 1998), 63 FR 64297 (November 19, 1998) (approving File Nos....

  3. 76 FR 1208 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

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    2011-01-07

    ... Release Nos. 62663 (August 9, 2010), 75 FR 49543 (August 13, 2010) (SR-NASDAQ-2010-077) (order approving... (August 10, 2010), 75 FR 50020 (August 16, 2010) (SR-EDGA-2010-06) (order approving fees for both 1G and... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate...

  4. 76 FR 44388 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-25

    ...), 75 FR 47335 (August 5, 2010) (SR-BATS-2010-020) (notice of filing and immediate effectiveness...), 76 FR 8793 (February 15, 2011) (SR-Phlx-2010-183) (order granting approval of expansion of short term... Exchange Act Release Nos. 64009 (March 2, 2011), 76 FR 12771 (March 8, 2011) (SR-BX-2011-014) (notice...

  5. 77 FR 55885 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-11

    ... Securities Exchange Act Rel. No. 51325 (Mar. 7, 2005), 70 FR 12522 (Mar. 14, 2005). The IM was renumbered and.... 24, 2007), 72 FR 4574 (Jan. 31, 2007) (File Nos. SR-NASD-2003-158 and SR-NASD-2004-011). 2. Statutory... Proposed Rule Change To Amend the By-Laws of FINRA Dispute Resolution, Inc. To Clarify That...

  6. 78 FR 15090 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-08

    ...). \\8\\ See Securities Exchange Act Release No. 44025 (February 28, 2001) 66 FR 13986 (March 8, 2001... Securities Exchange Act Release Nos. 67948 (September 28, 2012), 77 FR 60735 (October 4, 2012) (SR-NYSEArca..., 2013), 78 FR 6382 (January 30, 2013) (SR-NASDAQ-2013-011). Notice of filing and immediate...

  7. 77 FR 16883 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-22

    ..., 2011), 76 FR 55969 (September 9, 2011) (SR-C2-2011-008) (``SPXPM Filing''). Reintroduction of P.M...., Securities Exchange Act Release Nos. 45956 (May 17, 2002), 67 FR 36740 (May 24, 2002) (adopting release... artificially drive up or down share prices.''); 24367 (April 17, 1987), 52 FR 13890 (April 27, 1987)...

  8. 76 FR 76472 - Self-Regulatory Organizations; NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-07

    ... effectiveness adding seventy-five classes to Penny Pilot); and 62029 (May 4, 2010), 75 FR 25895 (May 10, 2010... Securities Exchange Act Release Nos. 57579 (March 28, 2008), 73 FR 18587 (April 4, 2008) (SR-NASDAQ-2008-026) (notice of filing and immediate effectiveness establishing Penny Pilot); 60874 (October 23, 2009), 74...

  9. 78 FR 9981 - Self-Regulatory Organizations; Chicago Stock Exchange, Inc.; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-12

    ..., 2012), 77 FR 47479 (August 8, 2012) (SR-CHX-2012-12). ] CHX Article 20, Rule 2 requires the Exchange to... Act Release No. 62252 (June 10, 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS-2010-014; SR... Securities Exchange Act Release No. 62251 (June 10, 2010), 75 FR 34183 (June 16, 2010)...

  10. 78 FR 76691 - Self-Regulatory Organizations; BOX Options Exchange LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-18

    .... See Securities Exchange Act Release Nos. 66871 (April 27, 2012) 77 FR 26323 (May 3, 2012) (File No.10... Securities Exchange Findings, Opinion, and Order of the Commission), 67328 (June 29, 2012) 77 FR 40123 (July 6, 2012) (SR-BOX-2012-007), 68425 (December 13, 2012) 77 FR 75234 (December 19, 2013)...

  11. 76 FR 20764 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    ... option classes. See Securities Exchange Act Release No. 35993 (July 19, 1995), 60 FR 38073 (July 25, 1995... (November 12, 1998), 63 FR 64297 (November 19, 1998) (approving File Nos. SR-Amex- 98-21, SR-CBOE-98-29, SR... Strike Price Program. See Securities Exchange Act Release No. 52960 (December 15, 2005), 70 FR...

  12. 77 FR 15417 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-15

    .... 56955 (December 13, 2007); 72 FR 71979 (December 19, 2007) (SR-ISE-2007-101). On December 23, 2008, the... (December 22, 2008); 73 FR 79954 (December 30, 2008) (SR-ISE-2008-85). On May 7, 2009, Direct Edge's direct... Release No. 60651 (September 11, 2009); 74 FR 47827 (September 17, 2009) (File Nos. 10-193 and 10-194)....

  13. 77 FR 19391 - Self-Regulatory Organizations; EDGA Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-30

    ... Release No. 65564 (October 14, 2011), 76 FR 65264 (October 20, 2011) (SR-EDGA-2011-34). \\5\\ See Securities Exchange Act Release No. 66171 (January 17, 2012), 77 FR 3297 (January 23, 2012) (File Nos. SR-EDGA-2011-34... NYSE Euronext and Deutsche B rse AG Will Not Become Effective March 26, 2012. Pursuant to Section...

  14. 77 FR 19400 - Self-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-30

    ... Release No. 65565 (October 14, 2011), 76 FR 65255 (October 20, 2011) (SR-EDGX-2011-33). \\5\\ See Securities Exchange Act Release No. 66171 (January 17, 2012), 77 FR 3297 (January 23, 2012) (File Nos. SR-EDGA-2011-34... NYSE Euronext and Deutsche B rse AG Will Not Become Effective March 26, 2012 Pursuant to Section...

  15. 78 FR 28692 - Self-Regulatory Organizations; BOX Options Exchange LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-15

    ... Securities Exchange Act Release No. 69511 (May 03, 2013), 78 FR 27271 (May 9, 2013) (Order Approving SR-BOX-2013-06). \\5\\ Id. \\6\\ Id. \\7\\ See Securities Exchange Act Release Nos. 69154 (March 15, 2013), 78 FR..., 2013), 78 FR 19562 (April 1, 2013) (Notice of Filing and Immediate Effectiveness of SR-BOX-2013-18)...

  16. 76 FR 61413 - Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-04

    ... Exchange's Web site at http://nasdaqomxphlx.cchwallstreet.com/NASDAQOMXPHLX/Filings/ , at the Exchange's... Exchange Act Release No. 48013 (June 11, 2003), 68 FR 35933 (June 17, 2003) (SR-Phlx-2002-55) (approval of... 1101A(b)(iii), respectively. \\6\\ Securities Exchange Act Release Nos. 49801 (June 3, 2004), 69 FR...

  17. 76 FR 39463 - Self-Regulatory Organizations; National Securities Clearing Corporation; Notice of Filing of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-06

    .... SR-NSCC-2010-01], 75 FR 10542 (March 8, 2010). \\6\\ In order to distinguish securities transfers from... information on the Obligation Warehouse service, see Exchange Act Release 63588 (December 21, 2010), 75 FR... NSCC, see Exchange Act Release No. 40179 (July 8, 1998), 63 FR 38221 (July 15, 1998) (File Nos....

  18. 77 FR 2335 - Self-Regulatory Organizations; NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-17

    ... Release No. 61358 (January 14, 2010), 75 FR 3594 (January 21, 2010) (Concept Release on Equity Market... December 31, 2011. See Securities Exchange Act Release Nos. 57579 (March 28, 2008), 73 FR 18587 (April 4... (October 23, 2009), 74 FR 56682 (November 2, 2009)(SR-NASDAQ-2009-091)(notice of filing and...

  19. 15 CFR Supplement Nos. 3-4 to Part... - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Nos. Supplement Nos. 3-4 to Part 742 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF... CONTROLS Supplement Nos. 3-4 to Part 742...

  20. 15 CFR Supplement Nos. 3-4 to Part... - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Nos. Supplement Nos. 3-4 to Part 742 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF... CONTROLS Supplement Nos. 3-4 to Part 742...

  1. 15 CFR Supplement Nos. 3-4 to Part... - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false Nos. Supplement Nos. 3-4 to Part 742 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF... CONTROLS Supplement Nos. 3-4 to Part 742...

  2. 15 CFR Supplement Nos. 3-4 to Part... - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Nos. Supplement Nos. 3-4 to Part 742 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF... CONTROLS Supplement Nos. 3-4 to Part 742...

  3. 15 CFR Supplement Nos. 3-4 to Part... - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false Nos. Supplement Nos. 3-4 to Part 742 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF... CONTROLS Supplement Nos. 3-4 to Part 742...

  4. Medical image file formats.

    PubMed

    Larobina, Michele; Murino, Loredana

    2014-04-01

    Image file format is often a confusing aspect for someone wishing to process medical images. This article presents a demystifying overview of the major file formats currently used in medical imaging: Analyze, Neuroimaging Informatics Technology Initiative (Nifti), Minc, and Digital Imaging and Communications in Medicine (Dicom). Concepts common to all file formats, such as pixel depth, photometric interpretation, metadata, and pixel data, are first presented. Then, the characteristics and strengths of the various formats are discussed. The review concludes with some predictive considerations about the future trends in medical image file formats.

  5. Medical image file formats.

    PubMed

    Larobina, Michele; Murino, Loredana

    2014-04-01

    Image file format is often a confusing aspect for someone wishing to process medical images. This article presents a demystifying overview of the major file formats currently used in medical imaging: Analyze, Neuroimaging Informatics Technology Initiative (Nifti), Minc, and Digital Imaging and Communications in Medicine (Dicom). Concepts common to all file formats, such as pixel depth, photometric interpretation, metadata, and pixel data, are first presented. Then, the characteristics and strengths of the various formats are discussed. The review concludes with some predictive considerations about the future trends in medical image file formats. PMID:24338090

  6. Transcriptional regulation of the human iNOS gene by IL-1beta in endothelial cells.

    PubMed Central

    Kolyada, A. Y.; Madias, N. E.

    2001-01-01

    BACKGROUND: Vascular endothelium participates in the control of vascular tone and function via the release of nitric oxide (NO) by the endothelial-type NO synthase (eNOS). Inducible NO synthase (iNOS) expression in endothelial cells occurs in many clinical conditions following induction by lipopolysaccharide or cytokines and generates large quantities of NO that result in endothelial cell activation and dysfunction. No information exists on the transcriptional regulation of the human iNOS gene (or that of other species) in endothelial cells. MATERIALS AND METHODS: We examined the transcriptional regulation of the human iNOS gene by interleukin-1beta (IL-1beta) in rat pulmonary microvascular endothelial cells (PVEC) by transient cotransfections of different iNOS-promoter constructs and cDNA of different transcription factors and regulatory proteins. RESULTS: The -1034/+88 bp iNOS promoter was strongly induced by IL-1beta, the regulatory elements for such induction being localized downstream of -205 bp. Cotransfection experiments with NF-kappaB isoforms, IkappaB isoforms, and IKK mutants suggested that the NF-kappaB site at -115/-106 bp is important, but not sufficient, for induction of iNOS promoter and that the role of NF-kappaB is partially independent of its binding site. C/EBP sites within the -205/+88 bp region were shown to be responsible, along with NF-kappaB site, for induction of iNOS promoter by IL-1beta. Overexpression of C/EBPalpha, C/EBPdelta, and liver-enriched activator protein (LAP) activated the promoter, whereas overexpression of liver-enriched inhibitory protein (LIP) strongly suppressed it. C/EBPbeta (LAP and LIP isoforms) was constitutively present in PVEC and was induced (approximately 2-fold) by IL-1beta, whereas C/EBPdelta was not constitutively expressed but was strongly induced by IL-1beta. Both C/EBPbeta and C/EBPdelta participated in DNA-protein complex formation. CONCLUSION: Both NF-kappaB and C/EBP pathways are important for the

  7. Mechanisms and Consequences of eNOS Dysfunction in Hypertension

    PubMed Central

    Li, Qiang; Yon, Ji-Youn; Cai, Hua

    2016-01-01

    Reduced nitric oxide (NO) bioavailability contributes to endothelial dysfunction and hypertension. The endothelial isoform of NO synthase (eNOS) is responsible for the production of NO within endothelium. Loss of eNOS cofactor tetrahydrobiopterin to initial increase in oxidative stress leads to uncoupling of eNOS, in which the enzyme produces superoxide anion rather than NO, further substantiating oxidative stress to induce vascular pathogenesis. The current review focuses on recent advances on the molecular mechanisms and consequences of eNOS dysfunction in hypertension, and potential novel therapeutic strategies restoring eNOS function to treat hypertension. PMID:25882860

  8. NOS knockout or inhibition but not disrupting PSD-95-NOS interaction protect against ischemic brain damage.

    PubMed

    Kleinschnitz, Christoph; Mencl, Stine; Kleikers, Pamela Wm; Schuhmann, Michael K; G López, Manuela; Casas, Ana I; Sürün, Bilge; Reif, Andreas; Schmidt, Harald Hhw

    2016-09-01

    Promising results have been reported in preclinical stroke target validation for pharmacological principles that disrupt the N-methyl-D-aspartate receptor-post-synaptic density protein-95-neuronal nitric oxide synthase complex. However, post-synaptic density protein-95 is also coupled to potentially neuroprotective mechanisms. As post-synaptic density protein-95 inhibitors may interfere with potentially neuroprotective mechanisms and sufficient validation has often been an issue in translating basic stroke research, we wanted to close that gap by comparing post-synaptic density protein-95 inhibitors with NOS1(-/-) mice and a NOS inhibitor. We confirm the deleterious role of NOS1 in stroke both in vivo and in vitro, but find three pharmacological post-synaptic density protein-95 inhibitors to be therapeutically ineffective. PMID:27354091

  9. 21 CFR 516.147 - Refuse to file a request for addition to the index.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 6 2014-04-01 2014-04-01 false Refuse to file a request for addition to the index... SPECIES Index of Legally Marketed Unapproved New Animal Drugs for Minor Species § 516.147 Refuse to file a request for addition to the index. (a) If a request for addition to the index contains all of...

  10. Register file soft error recovery

    SciTech Connect

    Fleischer, Bruce M.; Fox, Thomas W.; Wait, Charles D.; Muff, Adam J.; Watson, III, Alfred T.

    2013-10-15

    Register file soft error recovery including a system that includes a first register file and a second register file that mirrors the first register file. The system also includes an arithmetic pipeline for receiving data read from the first register file, and error detection circuitry to detect whether the data read from the first register file includes corrupted data. The system further includes error recovery circuitry to insert an error recovery instruction into the arithmetic pipeline in response to detecting the corrupted data. The inserted error recovery instruction replaces the corrupted data in the first register file with a copy of the data from the second register file.

  11. JENDL Dosimetry File 99.

    2001-01-22

    Version 00 JENDL/D-99 contains information for 47 nuclides and 67 reactions in the SAND-II group structure (although it was observed by RSICC that not all of the processed files are in the SAND-II group structure) and as 0K preprocessed pointwise files.

  12. Hopper File Management Tool

    SciTech Connect

    Long, J W; O'Neill, N J; Smith, N G; Springmeyer, R R; Remmele, S; Richards, D A; Southon, J

    2004-11-15

    Hopper is a powerful interactive tool that allows users to transfer and manipulate files and directories by means of a graphical user interface. Users can connect to and manage resources using the major file transfer protocols. Implemented in Java, Hopper can be run almost anywhere: from an individual's desktop machine to large production machines. In a high-performance computing environment, managing files can become a difficult and time-consuming task that distracts from scientific work. Users must deal with multiple file transfer protocols, transferring enormous amounts of files between computer platforms, repeated authentication, organizing massive amounts of data, and other detailed but necessary tasks. This is often accomplished with a set of several different tools, each with its own interface and idiosyncrasies. Our goal is to develop tools for a more automated approach to file management that substantially improves users' ability to transfer, organize, search, and operate on collections of files. This paper describes the Hopper tool for advanced file management, including the software architecture, the functionality, and the user interface.

  13. The dual role of iNOS in cancer.

    PubMed

    Vannini, Federica; Kashfi, Khosrow; Nath, Niharika

    2015-12-01

    Nitric oxide (NO) is one of the 10 smallest molecules found in nature. It is a simple gaseous free radical whose predominant functions is that of a messenger through cGMP. In mammals, NO is synthesized by the enzyme nitric oxide synthase (NOS) of which there are three isoforms. Neuronal (nNOS, NOS1) and endothelial (eNOS, NOS3) are constitutive calcium-dependent forms of the enzyme that regulate neural and vascular function respectively. The third isoform (iNOS, NOS2), is calcium-independent and is inducible. In many tumors, iNOS expression is high, however, the role of iNOS during tumor development is very complex and quite perplexing, with both promoting and inhibiting actions having been described. This review will aim to summarize the dual actions of iNOS-derived NO showing that the microenvironment of the tumor is a contributing factor to these observations and ultimately to cellular outcomes. PMID:26335399

  14. The dual role of iNOS in cancer☆

    PubMed Central

    Vanini, Frederica; Kashfi, Khosrow; Nath, Niharika

    2015-01-01

    Nitric oxide (NO) is one of the 10 smallest molecules found in nature. It is a simple gaseous free radical whose predominant functions is that of a messenger through cGMP. In mammals, NO is synthesized by the enzyme nitric oxide synthase (NOS) of which there are three isoforms. Neuronal (nNOS, NOS1) and endothelial (eNOS, NOS3) are constitutive calcium-dependent forms of the enzyme that regulate neural and vascular function respectively. The third isoform (iNOS, NOS2), is calcium-independent and is inducible. In many tumors, iNOS expression is high, however, the role of iNOS during tumor development is very complex and quite perplexing, with both promoting and inhibiting actions having been described. This review will aim to summarize the dual actions of iNOS-derived NO showing that the microenvironment of the tumor is a contributing factor to these observations and ultimately to cellular outcomes. PMID:26335399

  15. Specifying PDD-NOS: A Comparison of PDD-NOS, Asperger Syndrome, and Autism

    ERIC Educational Resources Information Center

    Walker, Darlene R.; Thompson, Ann; Zwaigenbaum, Lonnie; Goldberg, Jeremy; Bryson, Susan E.; Mahoney, William J.; Strawbridge, Christina P.; Szatmari, Peter

    2004-01-01

    Objective: To describe the clinical characteristics of children given a diagnosis of pervasive developmental disorder-not otherwise specified (PDD-NOS) by expert clinicians and to compare these to the clinical characteristics of children given a diagnosis of autism and Asperger syndrome (AS). Method: Two hundred sixteen children with autism, 33…

  16. iNOS-dependent sweating and eNOS-dependent cutaneous vasodilation are evident in younger adults, but are diminished in older adults exercising in the heat.

    PubMed

    Fujii, Naoto; Meade, Robert D; Alexander, Lacy M; Akbari, Pegah; Foudil-Bey, Imane; Louie, Jeffrey C; Boulay, Pierre; Kenny, Glen P

    2016-02-01

    Nitric oxide synthase (NOS) contributes to sweating and cutaneous vasodilation during exercise in younger adults. We hypothesized that endothelial NOS (eNOS) and neuronal NOS (nNOS) mediate NOS-dependent sweating, whereas eNOS induces NOS-dependent cutaneous vasodilation in younger adults exercising in the heat. Further, aging may upregulate inducible NOS (iNOS), which may attenuate sweating and cutaneous vasodilator responses. We hypothesized that iNOS inhibition would augment sweating and cutaneous vasodilation in exercising older adults. Physically active younger (n = 12, 23 ± 4 yr) and older (n = 12, 60 ± 6 yr) adults performed two 30-min bouts of cycling at a fixed rate of metabolic heat production (400 W) in the heat (35°C). Sweat rate and cutaneous vascular conductance (CVC) were evaluated at four intradermal microdialysis sites with: 1) lactated Ringer (control), 2) nNOS inhibitor (nNOS-I, NPLA), 3) iNOS inhibitor (iNOS-I, 1400W), or 4) eNOS inhibitor (eNOS-I, LNAA). In younger adults during both exercise bouts, all inhibitors decreased sweating relative to control, albeit a lower sweat rate was observed at iNOS-I compared with eNOS-I and nNOS-I sites (all P < 0.05). CVC at the eNOS-I site was lower than control in younger adults throughout the intermittent exercise protocol (all P < 0.05). In older adults, there were no differences between control and iNOS-I sites for sweating and CVC during both exercise bouts (all P > 0.05). We show that iNOS and eNOS are the main contributors to NOS-dependent sweating and cutaneous vasodilation, respectively, in physically active younger adults exercising in the heat, and that iNOS inhibition does not alter sweating or cutaneous vasodilation in exercising physically active older adults.

  17. Expression of the nos gene and Firefly Flashing: A Test of the Nitric-Oxide-Mediated Flash Control Model

    PubMed Central

    Ohtsuki, Hajime; Yokoyama, Jun; Ohba, Nobuyoshi; Ohmiya, Yoshihiro; Kawata, Masakado

    2014-01-01

    Fireflies (Coleoptera: Lampyridae) emit various types of light that differ among species and populations of the same species. Their lights are assumed to be biological properties that play important ecological and evolutionary roles. Some species in the Lampyridae emit periodic luminescence, the patterns of which are characterized by species-specific intervals. In previous work, it was predicted that the nitric oxide (NO) regulates the oxygen supply required for the bioluminescence reaction of fireflies. Here, the expression of the NO synthase (NOS) mRNA in some fireflies was examined to verify the predictive model of nitric-oxide-mediated flash control in these insects. The expression of the nos gene in the lantern organ was observed not only in nocturnal flashing species but also in diurnal non-flashing species. It was shown that the expression levels of nos were higher in the lantern of Luciola cruciata (Motschulsky) larvae, which that emits continuous light, than in other body parts, although expression in the lantern of the adults, who flash periodically, was not high. Furthermore, there was no significant difference in expression levels among adults of Luciola cruciata characterized by different flashing intervals. The data do not support the model of an NO-mediated flash control mechanism, during which oxygen becomes available for the luciferin-luciferase reaction through NO-mediated inhibition of mitochondrial respiration. It is also indicated that flash patterns do not co-vary with NOS production. However, high nos expression in the larval lantern suggests that NO may play a role in producing continuous light by functioning as a neurotransmitter signal for bioluminescence. PMID:25373203

  18. Expression of the nos gene and firefly flashing: a test of the nitric-oxide-mediated flash control model.

    PubMed

    Ohtsuki, Hajime; Yokoyama, Jun; Ohba, Nobuyoshi; Ohmiya, Yoshihiro; Kawata, Masakado

    2014-04-19

    Fireflies (Coleoptera: Lampyridae) emit various types of light that differ among species and populations of the same species. Their lights are assumed to be biological properties that play important ecological and evolutionary roles. Some species in the Lampyridae emit periodic luminescence, the patterns of which are characterized by species-specific intervals. In previous work, it was predicted that the nitric oxide (NO) regulates the oxygen supply required for the bioluminescence reaction of fireflies. Here, the expression of the NO synthase (NOS) mRNA in some fireflies was examined to verify the predictive model of nitric-oxide-mediated flash control in these insects. The expression of the nos gene in the lantern organ was observed not only in nocturnal flashing species but also in diurnal non-flashing species. It was shown that the expression levels of nos were higher in the lantern of Luciola cruciata (Motschulsky) larvae, which that emits continuous light, than in other body parts, although expression in the lantern of the adults, who flash periodically, was not high. Furthermore, there was no significant difference in expression levels among adults of Luciola cruciata characterized by different flashing intervals. The data do not support the model of an NO-mediated flash control mechanism, during which oxygen becomes available for the luciferin-luciferase reaction through NO-mediated inhibition of mitochondrial respiration. It is also indicated that flash patterns do not co-vary with NOS production. However, high nos expression in the larval lantern suggests that NO may play a role in producing continuous light by functioning as a neurotransmitter signal for bioluminescence.

  19. Diminished Neurogenic Femoral Artery Vasoconstrictor Response in a Zucker Obese Rat Model: Differential Regulation of NOS and COX Derivatives

    PubMed Central

    Martínez, Ana Cristina; Hernández, Medardo; Novella, Susana; Martínez, María Pilar; Pagán, Rosa María; Hermenegildo, Carlos; García-Sacristán, Albino; Prieto, Dolores; Benedito, Sara

    2014-01-01

    Objective Peripheral arterial disease is one of the macrovascular complications of type 2 diabetes mellitus. This study addresses femoral artery regulation in a prediabetic model of obese Zucker rats (OZR) by examining cross-talk between endothelial and neural factors. Methods and Results Arterial preparations from lean (LZR) and OZR were subjected to electrical field stimulation (EFS) on basal tone. Nitric oxide synthase (NOS) and cyclooxygenase (COX) isoform expression patterns were determined by immunohistochemical labelling and Western blotting. Results indicate significantly reduced noradrenergic contractions in preparations from OZR compared with those of LZR. Functional inhibition of endothelial NOS (eNOS) indicated a predominant role of this isoform in LZR and its modified activity in OZR. Neural (nNOS) and inducible NOS (iNOS) were activated and their expression was higher in femoral arteries from OZR. Neurotransmission modulated by large-conductance Ca2+-activated (BKCa) or voltage-dependent (KV) K+ channels did not seem compromised in the obese animals. Endothelial COX-1 and COX-2 were expressed in LZR and an additional adventitial location of COX-2 was also observed in OZR, explaining the higher COX-2 protein levels detected in this group. Prostanoids derived from both isoforms helped maintain vasoconstriction in LZR while in OZR only COX-2 was active. Superoxide anion inhibition reduced contractions in endothelium-intact arteries from OZR. Conclusions Endothelial dysfunction led to reduced neurogenic vasoconstriction in femoral arteries from OZR. In a setting of obesity, NO-dependent nNOS and iNOS dilation activity could be an alternative mechanism to offset COX-2- and reactive oxygen species-mediated vasoconstriction, along with impaired endothelial NO relaxation. PMID:25216050

  20. Construction of file database management

    SciTech Connect

    MERRILL,KYLE J.

    2000-03-01

    This work created a database for tracking data analysis files from multiple lab techniques and equipment stored on a central file server. Experimental details appropriate for each file type are pulled from the file header and stored in a searchable database. The database also stores specific location and self-directory structure for each data file. Queries can be run on the database according to file type, sample type or other experimental parameters. The database was constructed in Microsoft Access and Visual Basic was used for extraction of information from the file header.

  1. 75 FR 39206 - Marine Mammals; File Nos. 87-1851 and 555-1870

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-08

    ... No. 87-1851- 02, issued December 28, 2009 (75 FR 106) and Permit No. 555-1870-01, issued February 24, 2010 (75 FR 11132) is requested under the authority of the Marine Mammal Protection Act of 1972, as... hereby given that Daniel P. Costa, PhD, University of California at Santa Cruz, Long Marine...

  2. 75 FR 43150 - Marine Mammals; File Nos. 10018, 13846, 14451, 14585, 14599, 14122, 14296, and 14353

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-23

    ... endangered blue whales (Balaenoptera musculus), fin whales (B. physalus), humpback whales, sei whales (B... Pacific right whale (Eubalaena japonica), fin whale, blue whale, Cuvier's beaked whale (Ziphius... playbacks; (4) to gray, minke, fin, sei, blue, and North Pacific right whales for biological sampling......

  3. 77 FR 35657 - Marine Mammals; File Nos. 16163, 16160, and 15569

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-14

    ... FR 213) that a request for permits to conduct research on marine mammals had been submitted by the... Party) , P.O. Box 945, Friday Harbor, WA 98250; and The Center for Whale Research (CWR; Kenneth...

  4. Expression of zebrafish nos2b surrounds oral cavity.

    PubMed

    Poon, Kar-Lai; Richardson, Michael; Korzh, Vladimir

    2008-06-01

    Inducible nitric oxide synthase (NOS2) catalyzes the production of nitric oxide (NO), and is one of the factors establishing innate immunity. In zebrafish, Nos2 is represented by nos2a and nos2b. Here, we report the cloning and expression pattern of the zebrafish nos2b gene, which does not seem to participate in induced immune response. nos2b was mapped to zebrafish linkage group 15. The spatial and temporal expression pattern of nos2b in embryonic zebrafish was analyzed by whole-mount in situ hybridization. nos2b is expressed constitutively in two primordia located along the ventral midline. The first group of cells contributes to the neurohypophysis. Initially at the level of the ventral hindbrain, the second group of cells migrates closely with the thyroid primordium to its final position at the basihyal by 3 dpf. Thus, the analysis of expression pattern of nos2b reveals complex morphogenetic movements resulting in its expression surrounding the oral cavity.

  5. 75 FR 30017 - Electronic Tariff Filings; Notice of Posting Regarding Filing Procedures for Electronically Filed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Electronic Tariff Filings; Notice of Posting Regarding Filing Procedures for Electronically Filed Tariffs May 21, 2010. Take Notice that the attached document ``Filing Procedures...

  6. 77 FR 42780 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing of Proposed Rule Change...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-20

    ... Act Release No. 62296 (June 15, 2010), 75 FR 35115 (June 21, 2010) (SR-Phlx-2010-84) (notice of filing... last expanded in 2011. See Securities Exchange Act Release No. 65776 (November 17, 2011), 76 FR 72482... exchanges have STO programs. See Securities Exchange Act Release Nos. 59824 (April 27, 2009), 74 FR...

  7. 77 FR 20090 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-03

    ... extended through June 30, 2012. See Securities Exchange Act Release Nos. 55153 (January 23, 2007), 72 FR...); 60873 (October 23, 2009), 74 FR 56675 (November 2, 2009) (SR-Phlx-2009-91) (notice of filing and immediate effectiveness expanding and extending Penny Pilot); 60966 (November 9, 2009), 74 FR...

  8. 75 FR 5829 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing of Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-04

    ... order flow. The Exchange places a high value on its Market Makers and believes that eliminating the... Securities Exchange Act Release Nos. 60405 (July 30, 2009), 74 FR 39362 (August 6, 2009) (File No. 4-546) (approval order for the Protection and Locked/Crossed Plan); and 60525 (August 18, 2009), 74 FR...

  9. 77 FR 15153 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing of Proposed Rule Change by...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-14

    ... (October 7, 2011), 76 FR 63977 (October 14, 2011) (SR-BATS-2011-040) (Notice of Filing and Immediate...). \\3\\ See Securities Exchange Act Release No. 62716 (August 13, 2010), 75 FR 51295 (August 19, 2010...). \\4\\ See Securities Exchange Act Release Nos. 62901 (September 13, 2010), 75 FR 57097 (September...

  10. 75 FR 17820 - Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of a Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-07

    .... 40761 (December 8, 1998), 63 FR 70952 (December 22, 1998). The listing standards in Rule 1009A are... other indexes to Rule 1101A, see Securities Exchange Act Release Nos. 57899 (June 2, 2008), 73 FR 32379..., 2008), 73 FR 15554 (March 24, 2008) (SR-Phlx- 2008-21) (notice of filing and immediate...

  11. 78 FR 41447 - Self-Regulatory Organizations; BATS Y-Exchange, Inc.; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-10

    ... proposal. \\5\\ Securities Exchange Act Release No. 34-64444 (May 9, 2011) 76 FR 28115 (May 13, 2011) (File... data.\\18\\ \\18\\ See Securities Exchange Act Release No. 51808 (June 9, 2005), 70 FR 37496 (June 29, 2005...). See also Securities Exchange Act Release Nos. 62876 (September 9, 2010), 75 FR 56624 (September...

  12. 75 FR 76759 - Self-Regulatory Organizations; NYSE Amex LLC; Notice of Filing and Immediate Effectiveness of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-09

    ... permanent or January 31, 2011. See Securities Exchange Act Release No. 62857 (September 7, 2010), 75 FR... FR 41264 (July 15, 2010) (SR-NYSEAmex-2010-31) (Notice of Filing of Amendment Nos. 2 and 3, and Order... Securities Exchange Act Release No. 58863 (October 27, 2008), 73 FR 65417 (November 3, 2008) (Notice...

  13. 78 FR 37863 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-24

    ... Securities Exchange Act Release Nos. 55153 (January 23, 2007), 72 FR 4553 (January 31, 2007) (SR-Phlx- 2006... FR 77174 (December 31, 2012) (SR-Phlx-2012-143) (notice of filing and immediate effectiveness... of Penny Pilot Issues That Have Been Delisted June 18, 2013. Pursuant to Section 19(b)(1) of...

  14. 78 FR 77509 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-23

    ... Act Release Nos. 55153 (January 23, 2007), 72 FR 4553 (January 31, 2007)(SR-Phlx- 2006-74) (notice of filing and approval order establishing Penny Pilot); and 69786 (June 18, 2013), 78 FR 37863 (June 24... Exchange Act Release No. 61061 (November 24, 2009), 74 FR 62857 (December 1, 2009)...

  15. 78 FR 14141 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-04

    ... Options Services LLC (``NOS''), a member of the Exchange and the Exchange's exclusive order router.\\4... No. 68025 (October 10, 2012), 77 FR 63398 (October 16, 2012) (SR-OCC-2012-18). C2 recently filed a...), 78 FR 8621 (February 6, 2013) (SR-C2-2013-004). \\8\\ C2 utilizes the following formula to...

  16. 78 FR 7822 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... Market Volatility. \\3\\ See Securities Exchange Act Release No. 67565 (August 1, 2012), 77 FR 47144... (June 10, 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS-2010-014; SR-EDGA-2010-01; SR-EDGX- 2010... Release No. 62251 (June 10, 2010), 75 FR 34183 (June 16, 2010) (SR-FINRA-2010-025). See also...

  17. 78 FR 77528 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-23

    ... extended in June 2013. See Securities Exchange Act Release Nos. 67256 (June 26, 2012), 77 FR 39277 (July 2... 18, 2013), 78 FR 37873 (June 24, 2013) (SR-BX-2013-039)(notice of filing and immediate effectiveness...), 74 FR 62857 (December 1, 2009) (SR-NYSEArca-2009-44). \\14\\ For purposes only of waiving the...

  18. 78 FR 75949 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-13

    ...'' means a Participant that has registered as a Market Maker on NOM pursuant to Chapter VII, Section 2, and... 31, 2013. See Securities Exchange Act Release Nos. 57579 (March 28, 2008), 73 FR 18587 (April 4, 2008... (October 23, 2009), 74 FR 56682 (November 2, 2009) (SR-NASDAQ-2009-091) (notice of filing and...

  19. 75 FR 47670 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-06

    ... extended through December 31, 2010. See Securities Exchange Act Release Nos. 57579 (March 28, 2008), 73 FR... Penny Pilot); 60874 (October 23, 2009), 74 FR 56682 (November 2, 2009) (SR-NASDAQ-2009-091) (notice of filing and immediate effectiveness expanding and extending Penny Pilot); 60965 (November 9, 2009), 74...

  20. 77 FR 15163 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-14

    ... implemented, see Securities Exchange Act Release No. 63270 (November 8, 2010), 75 FR 69489 (November 12, 2010... Securities Exchange Act Release Nos. 63414 (December 2, 2010), 75 FR 76505 (December 8, 2010) (NASDAQ-2010-153) (notice of filing and immediate effectiveness); 63628 (January 3, 2011), 76 FR 1201 (January...

  1. 77 FR 42541 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-19

    ... Securities Exchange Act Release Nos. 55153 (January 23, 2007), 72 FR 4553 (January 31, 2007)(SR-Phlx-2006-74)(notice of filing and approval order establishing Penny Pilot); 60873 (October 23, 2009), 74 FR 56675... Penny Pilot); 60966 (November 9, 2009), 74 FR 59331 (November 17, 2009)(SR-Phlx-2009- 94)(notice...

  2. 77 FR 36310 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-18

    ... Exchange Act Release Nos. 55153 (January 23, 2007), 72 FR 4553 (January 31, 2007) (SR-Phlx-2006-74) (notice of filing and approval order establishing Penny Pilot); 60873 (October 23, 2009), 74 FR 56675... Penny Pilot); 60966 (November 9, 2009), 74 FR 59331 (November 17, 2009) (SR-Phlx-2009-94) (notice...

  3. 76 FR 51114 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ...). \\12\\ See Securities Exchange Act Release Nos. 61483 (February 3, 2010), 75 FR 6753 (February 10, 2010..., 2010), 75 FR 40007 (July 13, 2010) (SR-BX-2010-045) (rule filings to enable the listing and trading of... Effectiveness of Proposed Rule Change Relating to Options on ETFS Gold Trust August 11, 2011. Pursuant...

  4. 78 FR 61418 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-03

    ... Release Nos. 67256 (June 26, 2012), 77 FR 39277 (July 2, 2012) (SR-BX-2012-030) (order approving BX Options rules and establishing Penny Pilot); 67342 (July 3, 2012), 77 FR 40666 (July 10, 2012) (SR-BX-2012... (December 21, 2012), 77 FR 77152 (December 31, 2012) (SR-BX-2012- 076) (notice of filing and...

  5. 77 FR 57614 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-18

    ... Exchange Act Release Nos. 57579 (March 28, 2008), 73 FR 18587 (April 4, 2008) (SR-NASDAQ-2008-026) (notice of filing and immediate effectiveness establishing Penny Pilot); 60874 (October 23, 2009), 74 FR... and extending Penny Pilot); 60965 (November 9, 2009), 74 FR 59292 (November 17, 2009)...

  6. 77 FR 63384 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-16

    ... 31, 2012. See Securities Exchange Act Release Nos. 57579 (March 28, 2008), 73 FR 18587 (April 4, 2008... (October 23, 2009), 74 FR 56682 (November 2, 2009) (SR-NASDAQ-2009-091) (notice of filing and immediate effectiveness expanding and extending Penny Pilot); 60965 (November 9, 2009), 74 FR 59292 (November 17,...

  7. 77 FR 45706 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing of Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-01

    ... Release No. 53128 (January 13, 2006), 71 FR 3550 (January 23, 2006) (File No. 10-131). The rule was amended in Securities Exchange Act Release Nos. 54155 (July 14, 2006), 71 FR 41291 (July 20, 2006) (SR-NASDAQ-2006-001); 60794 (October 6, 2009), 74 FR 52522 (October 13, 2009) (SR-NASDAQ-2009-084); and...

  8. 77 FR 19396 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-30

    ... Reference Room. \\4\\ See Securities Exchange Act Release No. 65562 (October 14, 2011), 76 FR 65288 (October... FR 3297 (January 23, 2012) (File Nos. SR-EDGA-2011-34; SR- EDGX-2011-33; SR-ISE-2011-69; SR-NYSE-2011... Between NYSE Euronext and Deutsche B rse AG Will Not Become Effective March 26, 2012. Pursuant to...

  9. 76 FR 43357 - Self-Regulatory Organizations; NYSE Amex LLC; Notice of Filing and Immediate Effectiveness of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-20

    ... Release No. 63375 (November 24, 2010), 75 FR 74759 (December 1, 2010) (Notice of filing of SR-FINRA- 2010-061). See also Securities Exchange Act Release No. 63999 (March 1, 2011), 76 FR 12380 (March 7, 2011... Nos. 56148 (July 26, 2007), 72 FR 42146 (August 1, 2007) (order approving the Agreement); 56147...

  10. 76 FR 43366 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-20

    ... Exchange Act Release No. 63375 (November 24, 2010), 75 FR 74759 (December 1, 2010) (Notice of filing of SR-FINRA- 2010-061). See also Securities Exchange Act Release No. 63999 (March 1, 2011), 76 FR 12380 (March... effective December 15, 2008.\\5\\ \\5\\ See Securities Exchange Act Release Nos. 56148 (July 26, 2007), 72...

  11. 77 FR 40127 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-06

    .... See Securities Exchange Act Release Nos. 57579 (March 28, 2008), 73 FR 18587 (April 4, 2008) (SR... 23, 2009), 74 FR 56682 (November 2, 2009) (SR-NASDAQ-2009-091) (notice of filing and immediate effectiveness expanding and extending Penny Pilot); 60965 (November 9, 2009), 74 FR 59292 (November 17,...

  12. 76 FR 64142 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing of Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-17

    ... Exchange Act Release No. 62297 (June 15, 2010), 75 FR 35111 (June 21, 2010) (SR-NASDAQ-2010-073) (notice of... Release No. 64826 (July 6, 2011), 76 FR 40969 (July 12, 2011) (SR-NASDAQ- 2011-090) (notice of filing and... approval of STO programs, see Securities Exchange Act Release Nos. 59824 (April 27, 2009), 74 FR 20518...

  13. 77 FR 16283 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-20

    ... Act Release Nos. 55153 (January 23, 2007), 72 FR 4553 (January 31, 2007) (SR-Phlx-2006-74) (notice of filing and approval order establishing Penny Pilot); 60873 (October 23, 2009), 74 FR 56675 (November 2... Pilot); 60966 (November 9, 2009), 74 FR 59331 (November 17, 2009) (SR-Phlx- 2009-94) (notice of...

  14. Converting CSV Files to RKSML Files

    NASA Technical Reports Server (NTRS)

    Trebi-Ollennu, Ashitey; Liebersbach, Robert

    2009-01-01

    A computer program converts, into a format suitable for processing on Earth, files of downlinked telemetric data pertaining to the operation of the Instrument Deployment Device (IDD), which is a robot arm on either of the Mars Explorer Rovers (MERs). The raw downlinked data files are in comma-separated- value (CSV) format. The present program converts the files into Rover Kinematics State Markup Language (RKSML), which is an Extensible Markup Language (XML) format that facilitates representation of operations of the IDD and enables analysis of the operations by means of the Rover Sequencing Validation Program (RSVP), which is used to build sequences of commanded operations for the MERs. After conversion by means of the present program, the downlinked data can be processed by RSVP, enabling the MER downlink operations team to play back the actual IDD activity represented by the telemetric data against the planned IDD activity. Thus, the present program enhances the diagnosis of anomalies that manifest themselves as differences between actual and planned IDD activities.

  15. Upregulated iNOS and oxidative damage to the cochlear stria vascularis due to noise stress.

    PubMed

    Shi, Xiaorui; Nuttall, Alfred L

    2003-03-28

    Our previous work has revealed increased nitric oxide (NO) production in the cochlear perilymph following noise stress. However, it is not clear if the increase of NO is related to iNOS and whether NO-related oxidative stress can cause vascular tissue damage. In this study, iNOS immunoreactivity, NO production, and reactive oxygen species (ROS) in the lateral wall were examined in normal mice and compared with similar animals exposed to 120 dBA broadband noise, 3 h/day, for 2 consecutive days. In the normal animals, iNOS expression was not observed in the vascular endothelium of the stria vascularis and only weak iNOS immunoactivity was detected in the marginal cells. However, expression of iNOS in the wall of the blood vessels of stria vascularis and marginal cells was observed after loud sound stress (LSS). Relatively low levels of NO production and low ROS activity were detected in the stria vascularis in the unstimulated condition. In contrast, NO production was increased and ROS activity was elevated in the stria vascularis after LSS. These changes were attenuated by the iNOS inhibitor, GW 274150. To explore whether noise induces apoptotic processes in the stria vascularis, we examined morphological changes in endothelial- and marginal-cells. In vitro, annexin-V phosphatidylserine (PS) (to label and detect early evidence of apoptosis) was combined with propidium iodide (PI) (to probe plasma membrane integrity). PI alone was used in fixed tissues to detect later stage apoptotic cells by morphology of the nuclei. Following LSS, PS was expressed on cell surfaces of endothelial cells of blood vessels and marginal cells of the stria vascularis. Later stage apoptosis, characterized by irregular nuclei and condensation of nuclei, was also observed in these cells. The data indicate that increased iNOS expression and production of both NO and ROS following noise stress may lead to marginal cell pathology, and the dysfunction of cochlear microcirculation by inducing

  16. Face and Emotion Recognition in MCDD versus PDD-NOS

    ERIC Educational Resources Information Center

    Herba, Catherine M.; de Bruin, Esther; Althaus, Monika; Verheij, Fop; Ferdinand, Robert F.

    2008-01-01

    Previous studies indicate that Multiple Complex Developmental Disorder (MCDD) children differ from PDD-NOS and autistic children on a symptom level and on psychophysiological functioning. Children with MCDD (n = 21) and PDD-NOS (n = 62) were compared on two facets of social-cognitive functioning: identification of neutral faces and facial…

  17. 15 CFR Supplement Nos. 2-3 to Part... - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Nos. Supplement Nos. 2-3 to Part 716 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS INITIAL AND...

  18. 15 CFR Supplement Nos. 2-3 to Part... - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false Nos. Supplement Nos. 2-3 to Part 716 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS INITIAL AND...

  19. 15 CFR Supplement Nos. 2-3 to Part... - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false Nos. Supplement Nos. 2-3 to Part 716 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS INITIAL AND...

  20. 15 CFR Supplement Nos. 2-3 to Part... - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Nos. Supplement Nos. 2-3 to Part 716 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS INITIAL AND...

  1. 15 CFR Supplement Nos. 2-3 to Part... - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Nos. Supplement Nos. 2-3 to Part 716 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS INITIAL AND...

  2. 76 FR 9771 - SFPP, L.P.; SFPP, L.P.; SFPP, L.P.; SFPP, L.P.; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket Nos. OR96-2-018; IS98-1-006; Docket Nos. OR92-8-033; OR93-5- 020; OR94-4-021; Docket No. IS06-215-003; Docket No. IS06-220-002] SFPP, L.P.; SFPP, L.P.; SFPP, L.P.; SFPP, L.P.; Notice of Filing Take notice that...

  3. Magnetic circular dichroism spectroscopic characterization of the NOS-like protein from Geobacillus stearothermophilus (gsNOS).

    PubMed

    Kinloch, Ryan D; Sono, Masanori; Sudhamsu, Jawahar; Crane, Brian R; Dawson, John H

    2010-03-01

    Nitric oxide synthase (NOS) catalyzes the NADPH- and O(2)-dependent oxidation of l-arginine (l-Arg) to nitric oxide (NO) and citrulline via an N(G)-hydroxy-l-arginine (NHA) intermediate. Mammalian NOSs have been studied quite extensively; other eukaryotes and some prokaryotes appear to express NOS-like proteins comparable to the oxygenase domain of mammalian NOSs. In this study, a recombinant NOS-like protein from the thermostable bacterium Geobacillus stearothermophilus (gsNOS) has been characterized using magnetic circular dichroism (MCD) and UV-Vis absorption spectroscopic techniques. Spectral comparisons of ligand complexes (with O(2), NO and CO) of substrate-bound (l-Arg or NHA) gsNOS, including the key oxyferrous complex studied at -50 degrees C in cryogenic mixed solvents, with analogous mammalian NOS complexes indicate overall spectroscopic similarities between gsNOS and mammalian NOSs. However, more detailed spectral comparisons reflect subtle structural differences between gsNOS and mammalian NOSs. This may be due to an incomplete tetrahydrobiopterin (BH(4))-binding site and low BH(4)-binding affinity, which may become even lower in the presence of cryosolvent in gsNOS. Although BH(4)-binding may be altered, gsNOS appears to require the pterin for NO production since formation of the stable ferric-NO product complex was only observed when excess BH(4) (>150muM) over gsNOS was present upon single turnover reaction in which O(2) was bubbled into dithionite-reduced NHA-bound protein solution at -35 degrees C or -50 degrees C. PMID:20110129

  4. DSSTOX MASTER STRUCTURE-INDEX FILE: SDF FILE AND DOCUMENTATION

    EPA Science Inventory

    The DSSTox Master Structure-Index File serves to consolidate, manage, and ensure quality and uniformity of the chemical and substance information spanning all DSSTox Structure Data Files, including those in development but not yet published separately on this website.

  5. 76 FR 53676 - Combined Notice of Filings; Filings Instituting Proceedings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-29

    .... Eastern Time on Monday, August 29, 2011. Docket Numbers: RP11-2387-000. Applicants: Sabine Pipe Line LLC. Description: Sabine Pipe Line LLC submits tariff filing per 154.402: Sabine Pipe Line LLC 2011 ACA Filing...

  6. 76 FR 54460 - Combined Notice of Filings; Filings Instituting Proceedings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-01

    ... Numbers: RP11-2414-000. Applicants: Pine Needle LNG Company, LLC. Description: Pine Needle LNG Company, LLC submits tariff filing per 154.402: Pine Needle LNG Company 2011 ACA Filing to be effective...

  7. Vascular nitric oxide: Beyond eNOS.

    PubMed

    Zhao, Yingzi; Vanhoutte, Paul M; Leung, Susan W S

    2015-10-01

    As the first discovered gaseous signaling molecule, nitric oxide (NO) affects a number of cellular processes, including those involving vascular cells. This brief review summarizes the contribution of NO to the regulation of vascular tone and its sources in the blood vessel wall. NO regulates the degree of contraction of vascular smooth muscle cells mainly by stimulating soluble guanylyl cyclase (sGC) to produce cyclic guanosine monophosphate (cGMP), although cGMP-independent signaling [S-nitrosylation of target proteins, activation of sarco/endoplasmic reticulum calcium ATPase (SERCA) or production of cyclic inosine monophosphate (cIMP)] also can be involved. In the blood vessel wall, NO is produced mainly from l-arginine by the enzyme endothelial nitric oxide synthase (eNOS) but it can also be released non-enzymatically from S-nitrosothiols or from nitrate/nitrite. Dysfunction in the production and/or the bioavailability of NO characterizes endothelial dysfunction, which is associated with cardiovascular diseases such as hypertension and atherosclerosis. PMID:26499181

  8. Advancing the Perceptions of the Nature of Science (NOS): Integrating Teaching the NOS in a Science Content Course

    ERIC Educational Resources Information Center

    Aflalo, Ester

    2014-01-01

    Background: Understanding the nature of science (NOS) has been a key objective in teaching sciences for many years. Despite the importance of this goal it is, until this day, a complex challenge that we are far from achieving. Purpose: The study was conducted in order to further the understanding of the NOS amongst preservice teachers. It explores…

  9. Protein Inhibitor of NOS1 Plays a Central Role in the Regulation of NOS1 Activity in Human Dilated Hearts

    PubMed Central

    Roselló-Lletí, Esther; Tarazón, Estefanía; Ortega, Ana; Gil-Cayuela, Carolina; Carnicer, Ricardo; Lago, Francisca; González-Juanatey, Jose Ramón; Portolés, Manuel; Rivera, Miguel

    2016-01-01

    An essential factor for the production of nitric oxide by nitric oxide synthase 1 (NOS1), major modulator of cardiac function, is the cofactor tetrahydrobiopterin (BH4). BH4 is regulated by GTP cyclohydrolase 1, the rate-limiting enzyme in BH4 biosynthesis which catalyses the formation of dihydroneopterin 3′triphosfate from GTP, producing BH4 after two further steps catalyzed by 6-pyruvoyltetrahydropterin synthase and sepiapterin reductase. However, there are other essential factors involved in the regulation of NOS1 activity, such as protein inhibitor of NOS1 (PIN), calmodulin, heat shock protein 90, and NOS interacting protein. All these molecules have never been analysed in human non-ischemic dilated hearts (DCM). In this study we demonstrated that the upregulation of cardiac NOS1 is not accompanied by increased NOS1 activity in DCM, partly due to the elevated PIN levels and not because of alterations in biopterin biosynthesis. Notably, the PIN concentration was significantly associated with impaired ventricular function, highlighting the importance of this NOS1 activity inhibitor in Ca2+ homeostasis. These results take a central role in the current list of targets for future studies focused on the complex cardiac dysfunction processes through more efficient harnessing of NOS1 signalling. PMID:27481317

  10. Generic file format

    NASA Astrophysics Data System (ADS)

    Felgate, Nick

    2002-11-01

    The Generic File Format (GFF) is a file format developed within the UK ASW community for the interchange and storage of underwater sonar data. Originally developed for the interchange of time-series data between analysis systems, it has been extended to provide for storage of processed acoustic data (e.g., power and DEMON spectrum, lofargram grey-scale), nonacoustic data (e.g., own-ship dynamics, sensor configuration) and event data (e.g., tracker output, sonar intercepts). The format employs the chunk concept, as used in the WAV and AIFF file formats, to provide extendability (including local variants) while providing a measure of backward compatability. However, the basic concept has been adapted to allow for the mixing in the one file of multiple channels of different sample-rates and data-types through the inclusion of a data frame concept and multiple data blocks. Chunk cross-referencing has been employed to ensure data consistency. A provision is made in the header of the file to store details of the sensor and processing for the data (e.g., the number of hydrophones, beam direction, FFT size) so that an analysis system does not need to know about the sensor or other system from which the data originated.

  11. Endothelial NOS-dependent activation of c-Jun NH(2)- terminal kinase by oxidized low-density lipoprotein

    NASA Technical Reports Server (NTRS)

    Go, Y. M.; Levonen, A. L.; Moellering, D.; Ramachandran, A.; Patel, R. P.; Jo, H.; Darley-Usmar, V. M.

    2001-01-01

    Oxidized low-density lipoprotein (oxLDL) is known to activate a number of signal transduction pathways in endothelial cells. Among these are the c-Jun NH(2)-terminal kinase (JNK), also known as stress-activated protein kinase, and extracellular signal-regulated kinase (ERK). These mitogen-activated protein kinases (MAP kinase) determine cell survival in response to environmental stress. Interestingly, JNK signaling involves redox-sensitive mechanisms and is activated by reactive oxygen and nitrogen species derived from both NADPH oxidases, nitric oxide synthases (NOS), peroxides, and oxidized low-density lipoprotein (oxLDL). The role of endothelial NOS (eNOS) in the activation of JNK in response to oxLDL has not been examined. Herein, we show that on exposure of endothelial cells to oxLDL, both ERK and JNK are activated through independent signal transduction pathways. A key role of eNOS activation through a phosphatidylinositol-3-kinase-dependent mechanism leading to phosphorylation of eNOS is demonstrated for oxLDL-dependent activation of JNK. Moreover, we show that activation of ERK by oxLDL is critical in protection against the cytotoxicity of oxLDL.

  12. Using a Professional Development Program for Enhancing Chilean Biology Teachers' Understanding of Nature of Science (NOS) and Their Perceptions About Using History of Science to Teach NOS

    NASA Astrophysics Data System (ADS)

    Pavez, José M.; Vergara, Claudia A.; Santibañez, David; Cofré, Hernán

    2016-05-01

    A number of authors have recognized the importance of understanding the nature of science (NOS) for scientific literacy. Different instructional strategies such as decontextualized, hands-on inquiry, and history of science (HOS) activities have been proposed for teaching NOS. This article seeks to understand the contribution of HOS in enhancing biology teachers' understanding of NOS, and their perceptions about using HOS to teach NOS. These teachers ( N = 8), enrolled in a professional development program in Chile are, according to the national curriculum, expected to teach NOS, but have no specific NOS and HOS training. Teachers' views of NOS were assessed using the VNOS-D+ questionnaire at the beginning and at the end of two modules about science instruction and NOS. Both the pre- and the post-test were accompanied by interviews, and in the second session we collected information about teachers' perceptions of which interventions had been more significant in changing their views on NOS. Finally, the teachers also had to prepare a lesson plan for teaching NOS that included HOS. Some of the most important study results were: significant improvements were observed in teachers' understanding of NOS, although they assigned different levels of importance to HOS in these improvements; and although the teachers improved their understanding of NOS, most had difficulties in planning lessons about NOS and articulating historical episodes that incorporated NOS. The relationship between teachers' improved understanding of NOS and their instructional NOS skills is also discussed.

  13. XML Files: MedlinePlus

    MedlinePlus

    ... page: https://medlineplus.gov/xml.html MedlinePlus XML Files To use the sharing features on this page, ... information on all English and Spanish topic groups. Files generated on November 05, 2016 MedlinePlus Health Topic ...

  14. 76 FR 50210 - Combined Notice of Filings #

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-12

    ... 35.13(a)(2)(iii: Filing of Notice of Succession to be effective 10/5/2011. Filed Date: 08/05/2011....13(a)(2)(iii: Filing of Notice of Succession to be effective 10/5/2011. Filed Date: 08/05/2011....13(a)(2)(iii: Filing of Notice of Succession to be effective 10/5/2011. Filed Date:...

  15. NASA Thesaurus Data File

    NASA Technical Reports Server (NTRS)

    2012-01-01

    The NASA Thesaurus contains the authorized NASA subject terms used to index and retrieve materials in the NASA Aeronautics and Space Database (NA&SD) and NASA Technical Reports Server (NTRS). The scope of this controlled vocabulary includes not only aerospace engineering, but all supporting areas of engineering and physics, the natural space sciences (astronomy, astrophysics, planetary science), Earth sciences, and the biological sciences. The NASA Thesaurus Data File contains all valid terms and hierarchical relationships, USE references, and related terms in machine-readable form. The Data File is available in the following formats: RDF/SKOS, RDF/OWL, ZThes-1.0, and CSV/TXT.

  16. A Handbook on File Structuring.

    ERIC Educational Resources Information Center

    Shapiro, Robert M.; And Others

    An initial attempt at presenting a coherent approach to the design and analysis of file structures include a discussion of the relative effeciency of different file implementations as a function of usage statistics. The fundamental differences between item and descriptor-organized files are discussed in terms of input-output requirements.…

  17. Multimedia File Literacy for Students.

    ERIC Educational Resources Information Center

    Baker, William H.; Baker, Gary D.

    1997-01-01

    Argues that instructors can help to alleviate students' fears regarding different multimedia techniques by taking time to give some basic file explanations. Discusses a few of the most common multimedia file types in Windows (graphic, audio, and video), as well as compressed files. Uses slide show software as a base because of its widespread use…

  18. 78 FR 52190 - United States Department of Energy, Bonneville Power Administration: Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket Nos. EF13-7-000, EF13-8-000, EF13-9-000, EF13-10-000, EF13-11- 000, EF13-12-000, EF13-13-000, EF13-14-000] United States Department of Energy, Bonneville Power Administration: Notice of Filing Take notice that...

  19. 78 FR 10653 - Self-Regulatory Organizations; EDGA Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-14

    ... change is available on the Exchange's Internet Web site at www.directedge.com , at the Exchange's... Release No. 67501 (July 25, 2012), 77 FR 45396 (July 31, 2012) (SR-EDGA-2012-31). EDGA Rule 11.14 requires..., 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS-2010-014; SR-EDGA-2010-01; SR-EDGX- 2010-01;...

  20. 78 FR 10682 - Self-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-14

    ... change is available on the Exchange's Internet Web site at www.directedge.com , at the Exchange's... Release No. 67502 (July 25, 2012), 77 FR 45394 (July 31, 2012) (SR-EDGX-2012-28). EDGX Rule 11.14 requires..., 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS-2010-014; SR-EDGA-2010-01; SR-EDGX- 2010-01;...

  1. 76 FR 51082 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ... represents a ten percent or greater move in the transacted price of the security in a five-minute period. \\10... (June 10, 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS-2010-014; SR- EDGA-2010-01; SR-EDGX...), 75 FR 34183 (June 16, 2010) (SR-FINRA-2010- 025). \\5\\ See e.g., Securities Exchange Act Release...

  2. 76 FR 51103 - Self-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ..., five or ten percent beyond the price that triggered the pause. This scenario causes an inequity among a... (June 10, 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS-2010-014; SR- EDGA-2010-01; SR-EDGX-2010...-NASDAQ- 2010-061; SR-CHX-2010-10; SR-NSX- 2010-05; and SR-CBOE-2010-047); 62251 (June 10, 2010), 75...

  3. 76 FR 51084 - Self-Regulatory Organizations; EDGA Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ..., five or ten percent beyond the price that triggered the pause. This scenario causes an inequity among a... (June 10, 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS-2010-014; SR- EDGA-2010-01; SR-EDGX-2010...-NASDAQ- 2010-061; SR-CHX-2010-10; SR-NSX-2010-05; and SR-CBOE-2010-047); 62251 (June 10, 2010), 75...

  4. Accessing files in an Internet: The Jade file system

    NASA Technical Reports Server (NTRS)

    Peterson, Larry L.; Rao, Herman C.

    1991-01-01

    Jade is a new distribution file system that provides a uniform way to name and access files in an internet environment. It makes two important contributions. First, Jade is a logical system that integrates a heterogeneous collection of existing file systems, where heterogeneous means that the underlying file systems support different file access protocols. Jade is designed under the restriction that the underlying file system may not be modified. Second, rather than providing a global name space, Jade permits each user to define a private name space. These private name spaces support two novel features: they allow multiple file systems to be mounted under one directory, and they allow one logical name space to mount other logical name spaces. A prototype of the Jade File System was implemented on Sun Workstations running Unix. It consists of interfaces to the Unix file system, the Sun Network File System, the Andrew File System, and FTP. This paper motivates Jade's design, highlights several aspects of its implementation, and illustrates applications that can take advantage of its features.

  5. Accessing files in an internet - The Jade file system

    NASA Technical Reports Server (NTRS)

    Rao, Herman C.; Peterson, Larry L.

    1993-01-01

    Jade is a new distribution file system that provides a uniform way to name and access files in an internet environment. It makes two important contributions. First, Jade is a logical system that integrates a heterogeneous collection of existing file systems, where heterogeneous means that the underlying file systems support different file access protocols. Jade is designed under the restriction that the underlying file system may not be modified. Second, rather than providing a global name space, Jade permits each user to define a private name space. These private name spaces support two novel features: they allow multiple file systems to be mounted under one directory, and they allow one logical name space to mount other logical name spaces. A prototype of the Jade File System was implemented on Sun Workstations running Unix. It consists of interfaces to the Unix file system, the Sun Network File System, the Andrew File System, and FTP. This paper motivates Jade's design, highlights several aspects of its implementation, and illustrates applications that can take advantage of its features.

  6. β3-Adrenoreceptor stimulation protects against myocardial infarction injury via eNOS and nNOS activation.

    PubMed

    Niu, Xiaolin; Zhao, Lianyou; Li, Xue; Xue, Yusheng; Wang, Bin; Lv, Zongqiang; Chen, Jianghong; Sun, Dongdong; Zheng, Qiangsun

    2014-01-01

    β3-adrenergic receptor (AR) and the downstream signaling, nitric oxide synthase (NOS) isoforms, have been emerged as novel modulators of heart function and even potential therapeutic targets for cardiovascular diseases. However, it is not known whether β3-AR plays cardioprotective effects against myocardial infarction (MI) injury. Therefore, the present study was designed to determine the effects of β3-AR on MI injury and to elucidate the underlying mechanism. MI model was constructed by left anterior descending (LAD) artery ligation. Animals were administrated with β3-AR agonist BRL37344 (BRL) or β3-AR inhibitor SR59230A (SR) respectively at 0.1 mg/kg/hour one day after MI operation. The scar area, cardiac function and the apoptosis of myocardial were assessed by Masson's trichrome stain, echocardiography and TUNEL assay respectively. Western blot analysis was performed to elucidate the expressions of target proteins. β3-AR activation with BRL administration significantly attenuated fibrosis and decreased scar area after MI. Moreover, BRL also preserved heart function, and reduced the apoptosis of cardiomyocyte induced by MI. Furthermore, BRL treatment altered the phosphorylation status of endothelial NOS (eNOS) and increased the expression of neuronal NOS (nNOS). These results suggested that β3-AR stimulation has a substantial effect on recovery of heart function. In addition, the activations of both eNOS and nNOS may be associated with the cardiac protective effects of β3-AR.

  7. MPI File Tree Walk

    2007-04-30

    MPI-FTW is a scalable MPI based software application that navigates a directory tree by dynamically allocating processes to navigate sub-directories found. Upon completion, MPI-FTW provides statistics on the number of directories found, files found, and time to complete. Inaddition, commands can be executed at each directory level.

  8. The New Resource File

    ERIC Educational Resources Information Center

    Luck, Donald D.

    2011-01-01

    The development of the resource file is a common experience in teacher preparation programs. The author examines strategies for transforming what has been a project composed of physical resources to one emphasizing digital resources. Methods for finding, tagging, storing and retrieving resources are explored.

  9. "The Bean Files."

    ERIC Educational Resources Information Center

    Haq, Krystyna; Longnecker, Nancy; Hickey, Ruth

    1999-01-01

    Describes classroom use and effectiveness of "The Bean Files," an internet package that uses humorous stories to introduce students to life on a wheat-sheep farm in the Mediterranean climate areas of Australia. The focus of the program is on the role of legume-cereal rotations in the farming system and the science underpinning this agricultural…

  10. Illegal File Sharing 101

    ERIC Educational Resources Information Center

    Wada, Kent

    2008-01-01

    Much of higher education's unease arises from the cost of dealing with illegal file sharing. Illinois State University, for example, calculated a cost of $76 to process a first claim of copyright infringement and $146 for a second. Responses range from simply passing along claims to elaborate programs architected with specific goals in mind.…

  11. The Global File System

    NASA Technical Reports Server (NTRS)

    Soltis, Steven R.; Ruwart, Thomas M.; OKeefe, Matthew T.

    1996-01-01

    The global file system (GFS) is a prototype design for a distributed file system in which cluster nodes physically share storage devices connected via a network-like fiber channel. Networks and network-attached storage devices have advanced to a level of performance and extensibility so that the previous disadvantages of shared disk architectures are no longer valid. This shared storage architecture attempts to exploit the sophistication of storage device technologies whereas a server architecture diminishes a device's role to that of a simple component. GFS distributes the file system responsibilities across processing nodes, storage across the devices, and file system resources across the entire storage pool. GFS caches data on the storage devices instead of the main memories of the machines. Consistency is established by using a locking mechanism maintained by the storage devices to facilitate atomic read-modify-write operations. The locking mechanism is being prototyped in the Silicon Graphics IRIX operating system and is accessed using standard Unix commands and modules.

  12. 43 CFR 4.1371 - Who may file, where to file, when to file.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... of proposed suspension or rescission under 30 CFR 773.22 or a notice of suspension or rescission under 30 CFR 773.23 may file a request for review with the Hearings Division, Office of Hearings and... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Who may file, where to file, when to...

  13. 11 CFR 100.19 - File, filed or filing (2 U.S.C. 434(a)).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... to be filed under 11 CFR parts 101, 102, 104, 105, 107, 108, and 109, and any modifications or... required by 11 CFR part 105, by the close of business on the prescribed filing date. (b) Timely filed. (1... and in 11 CFR 104.5, (i) Overnight delivery service means a private delivery service business...

  14. 11 CFR 100.19 - File, filed or filing (2 U.S.C. 434(a)).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... a facsimile machine or by electronic mail if the reporting entity is not required to file... statement of electioneering communications may be filed using a facsimile machine or by electronic mail if... to be filed under 11 CFR parts 101, 102, 104, 105, 107, 108, and 109, and any modifications...

  15. Los Angeles County Poor Farm, Patient Ward Nos. 210 & ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Los Angeles County Poor Farm, Patient Ward Nos. 210 & 211 - Type B Plan, 7601 Imperial Highway; bounded by Esperanza Street, Laurel Street, Flores Street, and Descanso Street, Downey, Los Angeles County, CA

  16. FRONT ELEVATIONS, NOS. 2122 AND 2124 ON THE WEST SIDE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    FRONT ELEVATIONS, NOS. 2122 AND 2124 ON THE WEST SIDE OF UBER STREET, LOOKING WEST. - 2100 Block North Uber Street (Houses), East & west sides between Diamond Street & Susquehanna Avenue, Philadelphia, Philadelphia County, PA

  17. FRONT ELEVATIONS, NOS. 2123 AND 2125 ON THE EAST SIDE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    FRONT ELEVATIONS, NOS. 2123 AND 2125 ON THE EAST SIDE OF UBER STREET, LOOKING EAST. - 2100 Block North Uber Street (Houses), East & west sides between Diamond Street & Susquehanna Avenue, Philadelphia, Philadelphia County, PA

  18. Face and emotion recognition in MCDD versus PDD-NOS.

    PubMed

    Herba, Catherine M; de Bruin, Esther; Althaus, Monika; Verheij, Fop; Ferdinand, Robert F

    2008-04-01

    Previous studies indicate that Multiple Complex Developmental Disorder (MCDD) children differ from PDD-NOS and autistic children on a symptom level and on psychophysiological functioning. Children with MCDD (n = 21) and PDD-NOS (n = 62) were compared on two facets of social-cognitive functioning: identification of neutral faces and facial expressions. Few significant group differences emerged. Children with PDD-NOS demonstrated a more attention-demanding strategy of face processing, and processed neutral faces more similarly to complex patterns whereas children with MCDD showed an advantage for face recognition compared to complex patterns. Results further suggested that any disadvantage in face recognition was related more to the autistic features of the PDD-NOS group rather than characteristics specific to MCDD. No significant group differences emerged for identifying facial expressions.

  19. Vault Area (original section), east corridor, looking north (Vault Nos. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Vault Area (original section), east corridor, looking north (Vault Nos. 1-9 - Fort McNair, Film Store House, Fort Lesley J. McNair, P Street between Third & Fourth Streets, Southwest, Washington, District of Columbia, DC

  20. 37. ISLAND PLANT: Nos. 1 AND 2 TWENTYSIX INCH SPECIAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    37. ISLAND PLANT: Nos. 1 AND 2 TWENTY-SIX INCH SPECIAL HORIZONTAL SAMSON TURBINE (RIVITED CASE) - American Falls Water, Power & Light Company, Island Power Plant, Snake River, below American Falls Dam, American Falls, Power County, ID

  1. 36. ISLAND PLANT: Nos. 1 AND 2 TWENTYSIX INCH HORIZONTAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    36. ISLAND PLANT: Nos. 1 AND 2 TWENTY-SIX INCH HORIZONTAL SAMSON TURBINES - American Falls Water, Power & Light Company, Island Power Plant, Snake River, below American Falls Dam, American Falls, Power County, ID

  2. The different potential of sponge bacterial symbionts in N₂ release indicated by the phylogenetic diversity and abundance analyses of denitrification genes, nirK and nosZ.

    PubMed

    Zhang, Xia; He, Liming; Zhang, Fengli; Sun, Wei; Li, Zhiyong

    2013-01-01

    Nitrogen cycle is a critical biogeochemical process of the oceans. The nitrogen fixation by sponge cyanobacteria was early observed. Until recently, sponges were found to be able to release nitrogen gas. However the gene-level evidence for the role of bacterial symbionts from different species sponges in nitrogen gas release is limited. And meanwhile, the quanitative analysis of nitrogen cycle-related genes of sponge microbial symbionts is relatively lacking. The nirK gene encoding nitrite reductase which catalyzes soluble nitrite into gas NO and nosZ gene encoding nitrous oxide reductase which catalyzes N₂O into N₂ are two key functional genes in the complete denitrification pathway. In this study, using nirK and nosZ genes as markers, the potential of bacterial symbionts in six species of sponges in the release of N2 was investigated by phylogenetic analysis and real-time qPCR. As a result, totally, 2 OTUs of nirK and 5 OTUs of nosZ genes were detected by gene library-based saturated sequencing. Difference phylogenetic diversity of nirK and nosZ genes were observed at OTU level in sponges. Meanwhile, real-time qPCR analysis showed that Xestospongia testudinaria had the highest abundance of nosZ gene, while Cinachyrella sp. had the greatest abundance of nirK gene. Phylogenetic analysis showed that the nirK and nosZ genes were probably of Alpha-, Beta-, and Gammaproteobacteria origin. The results from this study suggest that the denitrification potential of bacteria varies among sponges because of the different phylogenetic diversity and relative abundance of nosZ and nirK genes in sponges. Totally, both the qualitative and quantitative analyses of nirK and nosZ genes indicated the different potential of sponge bacterial symbionts in the release of nitrogen gas. PMID:23762300

  3. eNOS Genetic Polymorphisms and Cancer Risk

    PubMed Central

    Gao, Xueren; Wang, Jie; Wang, Wenjun; Wang, Mingxi; Zhang, Jianqiong

    2015-01-01

    Abstract The association between endothelial nitric oxide synthase (eNOS) polymorphisms (intron 4a/b, -786T>C and 894G>T) and cancer risk remains elusive. In addition, no studies focused on their associations with the risk of breast cancer in Chinese Han population. Thus, a meta-analysis was conducted to determine the relationship between eNOS polymorphisms and cancer risk, and then a case–control study in Chinese Han population was performed to assess their associations with breast cancer susceptibility. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. The pooled analysis indicated that eNOS intron 4a/b and -786T>C polymorphisms were significantly associated with an increased risk of overall cancer. In subgroup analyses based on cancer type, the significant association was found between eNOS intron 4a/b polymorphism and prostate cancer risk, eNOS -786T>C polymorphism and risk of prostate, bladder and breast cancers, and eNOS 894G>T polymorphism and breast cancer risk. In subgroup analyses based on ethnicity, eNOS intron 4a/b and -786T>C polymorphisms were associated with an increased risk of cancer in Caucasians. In consistent with our meta-analysis results, a case–control study in Chinese Han population showed significant associations of eNOS -786T>C and 894G>T polymorphisms with the increased risk of breast cancer. In addition, stratified analyses based on pathological type showed that eNOS 894G>T polymorphism was only associated with the risk of infiltrative ductal carcinoma. Stratified analyses by tumor stage showed that eNOS -786T>C polymorphism was only associated with the risk of tumor stage III and IV. In conclusion, our meta-analysis and case–control study suggest that eNOS -786T>C and 894G>T polymorphisms are associated with the increased risk of breast cancer. PMID:26131841

  4. eNOS-uncoupling in age-related erectile dysfunction.

    PubMed

    Johnson, J M; Bivalacqua, T J; Lagoda, G A; Burnett, A L; Musicki, B

    2011-01-01

    Aging is associated with ED. Although age-related ED is attributed largely to increased oxidative stress and endothelial dysfunction in the penis, the molecular mechanisms underlying this effect are not fully defined. We evaluated whether endothelial nitric oxide synthase (eNOS) uncoupling in the aged rat penis is a contributing mechanism. Correlatively, we evaluated the effect of replacement with eNOS cofactor tetrahydrobiopterin (BH(4)) on erectile function in the aged rats. Male Fischer 344 'young' (4-month-old) and 'aged' (19-month-old) rats were treated with a BH(4) precursor sepiapterin (10 mg/kg intraperitoneally) or vehicle for 4 days. After 1-day washout, erectile function was assessed in response to electrical stimulation of the cavernous nerve. Endothelial dysfunction (eNOS uncoupling) and oxidative stress (thiobarbituric acid reactive substances, TBARS) were measured by conducting western blot in penes samples. Erectile response was significantly reduced in aged rats, whereas eNOS uncoupling and TBARS production were significantly increased in the aged rat penis compared with young rats. Sepiapterin significantly improved erectile response in aged rats and prevented increase in TBARS production, but did not affect eNOS uncoupling in the penis of aged rats. These findings suggest that aging induces eNOS uncoupling in the penis, resulting in increased oxidative stress and ED. PMID:21289638

  5. eNOS-uncoupling in age-related erectile dysfunction

    PubMed Central

    Johnson, JM; Bivalacqua, TJ; Lagoda, GA; Burnett, AL; Musicki, B

    2011-01-01

    Aging is associated with ED. Although age-related ED is attributed largely to increased oxidative stress and endothelial dysfunction in the penis, the molecular mechanisms underlying this effect are not fully defined. We evaluated whether endothelial nitric oxide synthase (eNOS) uncoupling in the aged rat penis is a contributing mechanism. Correlatively, we evaluated the effect of replacement with eNOS cofactor tetrahydrobiopterin (BH4) on erectile function in the aged rats. Male Fischer 344 ‘young’ (4-month-old) and ‘aged’ (19-month-old) rats were treated with a BH4 precursor sepiapterin (10 mg/kg intraperitoneally) or vehicle for 4 days. After 1-day washout, erectile function was assessed in response to electrical stimulation of the cavernous nerve. Endothelial dysfunction (eNOS uncoupling) and oxidative stress (thiobarbituric acid reactive substances, TBARS) were measured by conducting western blot in penes samples. Erectile response was significantly reduced in aged rats, whereas eNOS uncoupling and TBARS production were significantly increased in the aged rat penis compared with young rats. Sepiapterin significantly improved erectile response in aged rats and prevented increase in TBARS production, but did not affect eNOS uncoupling in the penis of aged rats. These findings suggest that aging induces eNOS uncoupling in the penis, resulting in increased oxidative stress and ED. PMID:21289638

  6. Investigating the Role of TNF-α and IFN-γ Activation on the Dynamics of iNOS Gene Expression in LPS Stimulated Macrophages

    PubMed Central

    Salim, Taha; Sershen, Cheryl L.; May, Elebeoba E.

    2016-01-01

    Macrophage produced inducible nitric oxide synthase (iNOS) is known to play a critical role in the proinflammatory response against intracellular pathogens by promoting the generation of bactericidal reactive nitrogen species. Robust and timely production of nitric oxide (NO) by iNOS and analogous production of reactive oxygen species are critical components of an effective immune response. In addition to pathogen associated lipopolysaccharides (LPS), iNOS gene expression is dependent on numerous proinflammatory cytokines in the cellular microenvironment of the macrophage, two of which include interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α). To understand the synergistic effect of IFN-γ and TNF-α activation, and LPS stimulation on iNOS expression dynamics and NO production, we developed a systems biology based mathematical model. Using our model, we investigated the impact of pre-infection cytokine exposure, or priming, on the system. We explored the essentiality of IFN-γ priming to the robustness of initial proinflammatory response with respect to the ability of macrophages to produce reactive species needed for pathogen clearance. Results from our theoretical studies indicated that IFN-γ and subsequent activation of IRF1 are essential in consequential production of iNOS upon LPS stimulation. We showed that IFN-γ priming at low concentrations greatly increases the effector response of macrophages against intracellular pathogens. Ultimately the model demonstrated that although TNF-α contributed towards a more rapid response time, measured as time to reach maximum iNOS production, IFN-γ stimulation was significantly more significant in terms of the maximum expression of iNOS and the concentration of NO produced. PMID:27276061

  7. Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis.

    PubMed

    Stadler, Krisztian; Bonini, Marcelo G; Dallas, Shannon; Duma, Danielle; Mason, Ronald P; Kadiiska, Maria B

    2008-08-01

    Diabetic patients frequently encounter ketosis that is characterized by the breakdown of lipids with the consequent accumulation of ketone bodies. Several studies have demonstrated that reactive species are likely to induce tissue damage in diabetes, but the role of the ketone bodies in the process has not been fully investigated. In this study, electron paramagnetic resonance (EPR) spectroscopy combined with novel spin-trapping and immunological techniques has been used to investigate in vivo free radical formation in a murine model of acetone-induced ketosis. A six-line EPR spectrum consistent with the alpha-(4-pyridyl-1-oxide)-N-t-butylnitrone radical adduct of a carbon-centered lipid-derived radical was detected in the liver extracts. To investigate the possible enzymatic source of these radicals, inducible nitric oxide synthase (iNOS) and NADPH oxidase knockout mice were used. Free radical production was unchanged in the NADPH oxidase knockout but much decreased in the iNOS knockout mice, suggesting a role for iNOS in free radical production. Longer-term exposure to acetone revealed iNOS overexpression in the liver together with protein radical formation, which was detected by confocal microscopy and a novel immunospin-trapping method. Immunohistochemical analysis revealed enhanced lipid peroxidation and protein oxidation as a consequence of persistent free radical generation after 21 days of acetone treatment in control and NADPH oxidase knockout but not in iNOS knockout mice. Taken together, our data demonstrate that acetone administration, a model of ketosis, can lead to protein oxidation and lipid peroxidation through a free radical-dependent mechanism driven mainly by iNOS overexpression.

  8. A poisonous plant file in TOXLINE.

    PubMed

    Wagstaff, D J; Wagstaff, A T; Goshorn, J C

    1989-01-01

    A file has been added to TOXLINE on the subject of the toxicology of poisonous plants. It contains 2508 records, each of which comprises the full reference, key words, Chemical Abstracts Service Registry Number and abstract when available. A controlled vocabulary was constructed for the indexing and can be obtained from the National Technical Information Service. Searches can be made for several different data elements including authors; year; significant textwords of the title or abstract; journal or book; document type such as review or case report; geographic place at the level of continent, nation and state/province; plant species at the level of family, genus and species; plant parts involved; animal species affected including humans; type of harmful effects including major signs and lesions and chemicals. PMID:2655182

  9. 77 FR 20793 - Marine Mammals; File No. 16599

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-06

    ... the Federal Register (77 FR 2512) that a request for a permit to conduct research on all species of... National Oceanic and Atmospheric Administration RIN 0648-XA905 Marine Mammals; File No. 16599 AGENCY... Dorian Houser, Ph.D., National Marine Mammal Foundation, 2240 Shelter Island Drive, 200, San Diego,...

  10. 78 FR 42756 - Marine Mammals; File No. 14330

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-17

    ... endangered and threatened species (50 CFR 222-226). Permit No. 14330, issued on August 17, 2009 (74 FR 44822... (76 FR 329), to include authorization for harassment of additional Steller sea lions and harbor seals... National Oceanic and Atmospheric Administration RIN 0648-XA122 Marine Mammals; File No. 14330...

  11. MERRA-2: File Specification

    NASA Technical Reports Server (NTRS)

    Bosilovich, M. G.; Lucchesi, R.; Suarez, M.

    2015-01-01

    The second Modern-Era Retrospective analysis for Research and Applications (MERRA-2) is a NASA atmospheric reanalysis that begins in 1980. It replaces the original MERRA reanalysis (Rienecker et al., 2011) using an upgraded version of the Goddard Earth Observing System Model, Version 5 (GEOS-5) data assimilation system. The file collections for MERRA-2 are described in detail in this document, including some important changes from those of the MERRA dataset (Lucchesi, 2012).

  12. Ageing single file motion

    NASA Astrophysics Data System (ADS)

    Metzler, R.; Sanders, L.; Lomholt, M. A.; Lizana, L.; Fogelmark, K.; Ambjörnsson, Tobias

    2014-12-01

    The mean squared displacement of a tracer particle in a single file of identical particles with excluded volume interactions shows the famed Harris scaling ≃ K1/2t1/2 as function of time. Here we study what happens to this law when each particle of the single file interacts with the environment such that it is transiently immobilised for times τ with a power-law distribution ψ(τ) ≃ (τ★)α, and different ranges of the exponent α are considered. We find a dramatic slow-down of the motion of a tracer particle from Harris' law to an ultraslow, logarithmic time evolution ≃ K0 log 1/2(t) when 0 < α < 1. In the intermediate case 1 < α < 2, we observe a power-law form for the mean squared displacement, with a modified scaling exponent as compared to Harris' law. Once α is larger than two, the Brownian single file behaviour and thus Harris' law are restored. We also point out that this process is weakly non-ergodic in the sense that the time and ensemble averaged mean squared displacements are disparate.

  13. Large File System Backup: NERSC Global File System Experience

    SciTech Connect

    Mokhtarani, Akbar; Andrews, Matthew; Hick, Jason; Kramer, William

    2008-10-23

    NERSC's Global File system (NGF), accessible from all compute systems at NERSC, holds files and data from many scientific projects. A full backup of this file system to our High Performance Storage System (HPSS) is performed periodically. Disk storage usage by projects at NERSC has grown seven fold over a two year period, from ~;;20TB in June 2006 to ~;;140 TB in June 2008. The latest full backup took about 13 days and more than 200 T10k tape cartridges (.5 TB capacity). Petabyte file systems are becoming a reality in the next few years and the existing utilities are already strained in handling backup tasks.

  14. 77 FR 35370 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-13

    .... Description: El Paso Natural Gas Company's 2011 (Jan-Mar) Penalty Credit Report. Filed Date: 5/31/12... following Natural Gas Pipeline Rate and Refund Report filings: Filings Instituting Proceedings Docket...-filing/efiling/filing-req.pdf . For other information, call (866) 208-3676 (toll free). For TTY,...

  15. 77 FR 71790 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-04

    ... following Natural Gas Pipeline Rate and Refund Report filings: Filings Instituting Proceedings Docket... Credit Response Filing to be effective 12/31/9998. Filed Date: 11/26/12. Accession Number: 20121126-5216.../filing-req.pdf . For other information, call (866) 208-3676 (toll free). For TTY, call (202) 502-...

  16. 77 FR 1927 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-12

    ... received the following Natural Gas Pipeline Rate and Refund Report filings: Filings Instituting Proceedings...: Reservation Credit Compliance to RP12-15 to be effective 1/12/2012. Filed Date: 1/4/12. Accession Number.../docs-filing/efiling/filing-req.pdf . For other information, call (866) 208-3676 (toll free). For...

  17. 48 CFR 4.802 - Contract files.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract files. 4.802... MATTERS Government Contract Files 4.802 Contract files. (a) A contract file should generally consist of— (1) The contracting office contract file, that documents the basis for the acquisition and the...

  18. Break up a File with EDLIN.

    ERIC Educational Resources Information Center

    Koga, James S.

    Online searchers who download large amounts of data into a single ASCII file often have difficulty fitting that large file into their MS-DOS word processors for post-processing. This paper gives step-by-step instructions for using EDLIN, a text editor for DOS files, to break up a large downloaded file into smaller files. (1 reference) (Author/EW)

  19. 48 CFR 4.802 - Contract files.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... MATTERS Government Contract Files 4.802 Contract files. (a) A contract file should generally consist of— (1) The contracting office contract file, that documents the basis for the acquisition and the award... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Contract files....

  20. 48 CFR 4.802 - Contract files.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... MATTERS Government Contract Files 4.802 Contract files. (a) A contract file should generally consist of— (1) The contracting office contract file, that documents the basis for the acquisition and the award... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Contract files....

  1. 12 CFR 5.4 - Filing required.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... CORPORATE ACTIVITIES Rules of General Applicability § 5.4 Filing required. (a) Filing. A depository institution shall file an application or notice with the OCC to engage in corporate activities and... advise an applicant through a pre-filing communication to send the filing or submission directly to...

  2. Expression analysis of NOS family and HSP genes during thermal stress in goat ( Capra hircus)

    NASA Astrophysics Data System (ADS)

    Yadav, Vijay Pratap; Dangi, Satyaveer Singh; Chouhan, Vikrant Singh; Gupta, Mahesh; Dangi, Saroj K.; Singh, Gyanendra; Maurya, Vijay Prakash; Kumar, Puneet; Sarkar, Mihir

    2016-03-01

    Approximately 50 genes other than heat shock protein (HSP) expression changes during thermal stress. These genes like nitric oxide synthase (NOS) need proper attention and investigation to find out their possible role in the adaptation to thermal stress in animals. So, the present study was undertaken to demonstrate the expressions of inducible form type II NOS (iNOS), endothelial type III NOS (eNOS), constitutively expressed enzyme NOS (cNOS), HSP70, and HSP90 in peripheral blood mononuclear cells (PBMCs) during different seasons in Barbari goats. Real-time polymerase chain reaction, western blot, and immunocytochemistry were applied to investigate messenger RNA (mRNA) expression, protein expression, and immunolocalization of examined factors. The mRNA and protein expressions of iNOS, eNOS, cNOS, HSP70, and HSP90 were significantly higher ( P < 0.05) during peak summer, and iNOS and eNOS expressions were also observed to be significantly higher ( P < 0.05) during peak winter season as compared with moderate season. The iNOS, eNOS, cNOS, HSP70, and HSP90 were mainly localized in plasma membrane and cytoplasm of PBMCs. To conclude, data generated in the present study indicate the possible involvement of the NOS family genes in amelioration of thermal stress so as to maintain cellular integrity and homeostasis in goats.

  3. Pedagogical Reflections by Secondary Science Teachers at Different NOS Implementation Levels

    NASA Astrophysics Data System (ADS)

    Herman, Benjamin C.; Clough, Michael P.; Olson, Joanne K.

    2015-10-01

    This study investigated what 13 secondary science teachers at various nature of science (NOS) instruction implementation levels talked about when they reflected on their teaching. We then determined if differences exist in the quality of those reflections between high, medium, and low NOS implementers. This study sought to answer the following questions: (1) What do teachers talk about when asked general questions about their pedagogy and NOS pedagogy and (2) what qualitative differences, if any, exist within variables across teachers of varying NOS implementation levels? Evidence derived from these teachers' reflections indicated that self-efficacy and perceptions of general importance for NOS instruction were poor indicators of NOS implementation. However, several factors were associated with the extent that these teachers implemented NOS instruction, including the utility value they hold for NOS teaching, considerations of how people learn, understanding of NOS pedagogy, and their ability to accurately and deeply self-reflect about teaching. Notably, those teachers who effectively implemented the NOS at higher levels value NOS instruction for reasons that transcend immediate instructional objectives. That is, they value teaching NOS for achieving compelling ends realized long after formal schooling (e.g., lifelong socioscientific decision-making for civic reasons), and they deeply reflect about how to teach NOS by drawing from research about how people learn. Low NOS implementers' simplistic notions and reflections about teaching and learning appeared to be impeding factors to accurate and consistent NOS implementation. This study has implications for science teacher education efforts that promote NOS instruction.

  4. The Galley Parallel File System

    NASA Technical Reports Server (NTRS)

    Nieuwejaar, Nils; Kotz, David

    1996-01-01

    As the I/O needs of parallel scientific applications increase, file systems for multiprocessors are being designed to provide applications with parallel access to multiple disks. Many parallel file systems present applications with a conventional Unix-like interface that allows the application to access multiple disks transparently. The interface conceals the parallelism within the file system, which increases the ease of programmability, but makes it difficult or impossible for sophisticated programmers and libraries to use knowledge about their I/O needs to exploit that parallelism. Furthermore, most current parallel file systems are optimized for a different workload than they are being asked to support. We introduce Galley, a new parallel file system that is intended to efficiently support realistic parallel workloads. We discuss Galley's file structure and application interface, as well as an application that has been implemented using that interface.

  5. The Galley Parallel File System

    NASA Technical Reports Server (NTRS)

    Nieuwejaar, Nils; Kotz, David

    1996-01-01

    Most current multiprocessor file systems are designed to use multiple disks in parallel, using the high aggregate bandwidth to meet the growing I/0 requirements of parallel scientific applications. Many multiprocessor file systems provide applications with a conventional Unix-like interface, allowing the application to access multiple disks transparently. This interface conceals the parallelism within the file system, increasing the ease of programmability, but making it difficult or impossible for sophisticated programmers and libraries to use knowledge about their I/O needs to exploit that parallelism. In addition to providing an insufficient interface, most current multiprocessor file systems are optimized for a different workload than they are being asked to support. We introduce Galley, a new parallel file system that is intended to efficiently support realistic scientific multiprocessor workloads. We discuss Galley's file structure and application interface, as well as the performance advantages offered by that interface.

  6. Species Conservation and Management: Case Studies

    USGS Publications Warehouse

    Akcakaya, H.R.; Burgman, M.A.; Kindvall, O.; Wood, C.C.; Sjogren-Gulve, P.; Hatfield, J.S.; McCarthy, M.A.

    2004-01-01

    This edited volume is a collection of population and metapopulation models for a wide variety of species, including plants, invertebrates, fishes, amphibians, reptiles, birds, and mammals. Each chapter of the book describes the application of RAMAS GIS 4.0 to one species, with the aim of demonstrating how various life history characteristics of the species are incorporated into the model, and how the results of the model has been or can be used in conservation and management of the species. The book comes with a CD that includes a demo version of the program, and the data files for each species.

  7. 43 CFR 4.1362 - Where to file; when to file.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Where to file; when to file. 4.1362... file; when to file. (a) The request for review shall be filed with the Hearings Division, Office of... bear the expense for this service. (b) Failure to file a request for review within the time...

  8. Modulating DDAH/NOS Pathway to Discover Vasoprotective Insulin Sensitizers

    PubMed Central

    Lai, Li; Ghebremariam, Yohannes T.

    2016-01-01

    Insulin resistance syndrome (IRS) is a configuration of cardiovascular risk factors involved in the development of metabolic disorders including type 2 diabetes mellitus. In addition to diet, age, socioeconomic, and environmental factors, genetic factors that impair insulin signaling are centrally involved in the development and exacerbation of IRS. Genetic and pharmacological studies have demonstrated that the nitric oxide (NO) synthase (NOS) genes are critically involved in the regulation of insulin-mediated glucose disposal. The generation of NO by the NOS enzymes is known to contribute to vascular homeostasis including insulin-mediated skeletal muscle vasodilation and insulin sensitivity. By contrast, excessive inhibition of NOS enzymes by exogenous or endogenous factors is associated with insulin resistance (IR). Asymmetric dimethylarginine (ADMA) is an endogenous molecule that competitively inhibits all the NOS enzymes and contributes to metabolic perturbations including IR. The concentration of ADMA in plasma and tissue is enzymatically regulated by dimethylarginine dimethylaminohydrolase (DDAH), a widely expressed enzyme in the cardiovascular system. In preclinical studies, overexpression of DDAH has been shown to reduce ADMA levels, improve vascular compliance, and increase insulin sensitivity. This review discusses the feasibility of the NOS/DDAH pathway as a novel target to develop vasoprotective insulin sensitizers. PMID:26770984

  9. Terminology Extraction from Log Files

    NASA Astrophysics Data System (ADS)

    Saneifar, Hassan; Bonniol, Stéphane; Laurent, Anne; Poncelet, Pascal; Roche, Mathieu

    The log files generated by digital systems can be used in management information systems as the source of important information on the condition of systems. However, log files are not exhaustively exploited in order to extract information. The classical methods of information extraction such as terminology extraction methods are irrelevant to this context because of the specific characteristics of log files like their heterogeneous structure, the special vocabulary and the fact that they do not respect a natural language grammar. In this paper, we introduce our approach Exterlog to extract the terminology from log files. We detail how it deals with the particularity of such textual data.

  10. Particle Physics Masterclass as a Context for Learning about NOS

    NASA Astrophysics Data System (ADS)

    Wadness, Michael

    2011-04-01

    This research addresses the question: Do secondary school science students attending the U.S. Particle Physics Masterclass change their view of the nature of science (NOS)? The U.S. Particle Physics Masterclass is a national physics outreach program run by QuarkNet, in which high school physics students gather at a local research institution for one day to learn about particle physics and the scientific enterprise. Student activities include introductory lectures in particle physics, laboratory tours, analysis of actual data from CERN, and the discussion of their findings in a conference-like atmosphere. Although there are a number of outreach programs involving scientists in K-12 education, very few of them have been formally evaluated to determine if they provide adequate learning of NOS. Therefore, the significance of this study is that it investigates the claim that science outreach programs may be designed to address science literacy, specifically as a context for explicit NOS instruction.

  11. 75 FR 67357 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-02

    .... Applicants: ETC Tiger Pipeline, LLC. Description: ETC Tiger Pipeline, LLC submits tariff filing per 154.203: Tiger FTSA Non-Conforming Agreement Filing to be effective 12/ 1/2010. Filed Date: 10/25/2010....

  12. Exploring Elementary Science Methods Course Contexts to Improve Preservice Teachers' NOS of Science Conceptions and Understandings of NOS Teaching Strategies

    ERIC Educational Resources Information Center

    Akerson, Valarie L.; Weiland, Ingrid; Rogers, Meredith Park; Pongsanon, Khemmawaddee; Bilican, Kader

    2014-01-01

    We explored adaptations to an elementary science methods course to determine how varied contexts could improve elementary preservice teachers' conceptions of NOS as well as their ideas for teaching NOS to elementary students. The contexts were (a) NOS Theme in which the course focused on the teaching of science through the consistent teaching…

  13. Converting Inhouse Subject Card Files to Electronic Keyword Files.

    ERIC Educational Resources Information Center

    Culmer, Carita M.

    The library at Phoenix College developed the Controversial Issues Files (CIF), a "home made" card file containing references pertinent to specific ongoing assignments. Although the CIF had proven itself to be an excellent resource tool for beginning researchers, it was cumbersome to maintain in the card format, and was limited to very general…

  14. Safety evaluation report related to the operation of Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391): Supplement No. 19

    SciTech Connect

    1995-11-01

    Supplement No. 19 to the Safety Evaluation Report for the application filed by the Tennessee Valley Authority for license to operate Watts Bar Nuclear Plant, Units 1 and 2, Docket Nos. 50-390 and 50-391, located in Rhea County Tennessee, has been prepared by the Office of Nuclear Reactor Regulation of the Nuclear Regulatory Commission. The purpose of this supplement is to update the Safety Evaluation with (1) additional information submitted by the applicant since Supplement No. 18 was issued, and (2) matters that the staff had under review when Supplement No. 18 was issued.

  15. Safety Evaluation Report related to the operation of Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391). Supplement No. 12

    SciTech Connect

    Tam, P.S.

    1993-10-01

    Supplement No. 12 to the Safety Evaluation Report for the application filed by the Tennessee Valley Authority for license to operate Watts Bar Nuclear Plant, Units 1 and 2, Docket Nos. 50-390 and 50-391, located in Rhea County, Tennessee, has been prepared by the Office of Nuclear Reactor Regulation of the Nuclear Regulatory Commission. The purpose of this supplement is to update the Safety Evaluation of (1) additional information submitted by the applicant since Supplement No. 11 was issued, and (2) matters that the staff had under review when Supplement No. 11 was issued.

  16. The DNA Files

    SciTech Connect

    1998-06-09

    The DNA Files is a radio documentary which disseminates genetics information over public radio. The documentaries explore subjects which include the following: How genetics affects society. How human life began and how it evolved. Could new prenatal genetic tests hold the key to disease prevention later in life? Would a national genetic data base sacrifice individual privacy? and Should genes that may lead to the cure for cancer be privately owned? This report serves as a project update for the second quarter of 1998. It includes the spring/summer 1998 newsletter, the winter 1998 newsletter, the program clock, and the latest flyer.

  17. 49 CFR 106.60 - Filing comments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS AND OIL TRANSPORTATION RULEMAKING PROCEDURES Participating in the Rulemaking Process Written Comments § 106.60 Filing comments. Anyone may file...

  18. The Internet Toolkit: File Compression and Archive Utilities.

    ERIC Educational Resources Information Center

    Delfino, Erik

    1993-01-01

    Describes utility programs available for posttransfer processing files that have been downloaded from the Internet. Highlights include file compression; viewing graphics files; converting binary files to ASCII files; and how to find utility programs. (LRW)

  19. Portable File Format (PFF) specifications.

    SciTech Connect

    Dolan, Daniel H.,

    2015-02-01

    Created at Sandia National Laboratories, the Portable File Format (PFF) allows binary data transfer across computer platforms. Although this capability is supported by many other formats, PFF files are still in use at Sandia, particularly in pulsed power research. This report provides detailed PFF specifications for accessing data without relying on legacy code.

  20. Aerospell Supplemental Spell Check File

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Aerospell is a supplemental spell check file that can be used as a resource for researchers, writers, editors, students, and others who compose scientific and technical texts. The file extends the general spell check dictionaries of word processors by adding more than 13,000 words used in a broad range of aerospace and related disciplines.

  1. Storing files in a parallel computing system using list-based index to identify replica files

    DOEpatents

    Faibish, Sorin; Bent, John M.; Tzelnic, Percy; Zhang, Zhenhua; Grider, Gary

    2015-07-21

    Improved techniques are provided for storing files in a parallel computing system using a list-based index to identify file replicas. A file and at least one replica of the file are stored in one or more storage nodes of the parallel computing system. An index for the file comprises at least one list comprising a pointer to a storage location of the file and a storage location of the at least one replica of the file. The file comprises one or more of a complete file and one or more sub-files. The index may also comprise a checksum value for one or more of the file and the replica(s) of the file. The checksum value can be evaluated to validate the file and/or the file replica(s). A query can be processed using the list.

  2. 4. Southwest fronts, dock nos. 491 and 492. Southeast end, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Southwest fronts, dock nos. 491 and 492. Southeast end, dock no. 492. View to north. - Offutt Air Force Base, Looking Glass Airborne Command Post, Nose Docks, On either side of Hangar Access Apron at Northwest end of Project Looking Glass Historic District, Bellevue, Sarpy County, NE

  3. Context view, Building Nos. 2728, looking north from a spot ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Context view, Building Nos. 27-28, looking north from a spot south of Building No. 28 - U.S. Veterans Hospital, Jefferson Barracks, Medical Officer in Charge Residence, VA Medical Center, Jefferson Barracks Division 1 Jefferson Barracks Drive, Saint Louis, Independent City, MO

  4. Context view, Building Nos. 2729, with Building No. 28 in ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Context view, Building Nos. 27-29, with Building No. 28 in the center, looking west at front of buildings, from a spot south of Building No. 29 - U.S. Veterans Hospital, Jefferson Barracks, Medical Officer in Charge Residence, VA Medical Center, Jefferson Barracks Division 1 Jefferson Barracks Drive, Saint Louis, Independent City, MO

  5. First light of the NIRISS Optical Simulator (NOS)

    NASA Astrophysics Data System (ADS)

    St-Antoine, Jonathan; Albert, Loïc.; Doyon, René; Vallée, Philippe; Artigau, Étienne; Hernandez, Olivier; Thibault, Simon; Brousseau, Denis

    2016-07-01

    The Near Infrared Imager and Slitless Spectrograph (NIRISS) Optical Simulator (NOS) is a laboratory simulation of the single-object slitless spectroscopy and aperture masking interferometry modes of the NIRISS instrument onboard the James Webb Space Telescope (JWST). A transiting exoplanet can be simulated by periodically eclipsing a small portion (1% - 10ppm) of a super continuum laser source (0.4 μm - 2.4 μm) with a dichloromethane filled cell. Dichloromethane exhibits multiple absorption features in the near infrared domain hence the net effect is analogous to the atmospheric absorption features of an exoplanet transiting in front of its host star. The NOS uses an HAWAII-2RG and an ASIC controller cooled to cryogenic temperatures. A separate photometric beacon provides a flux reference to monitor laser variations. The telescope jitter can be simulated using a high-resolution motorized pinhole placed along the optical path. Laboratory transiting spectroscopy data produced by the NOS will be used to refine analysis methods, characterize the noise due to the jitter, characterize the noise floor and to develop better observation strategies. We report in this paper the first exoplanet transit event simulated by the NOS. The performance is currently limited by relatively high thermal background in the system and high frequency temporal variations of the continuum source.

  6. AIRMEN'S BARRACKS (FACILITY Nos. 422, 442, AND 420) IN MIDDLE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    AIRMEN'S BARRACKS (FACILITY Nos. 422, 442, AND 420) IN MIDDLE DISTANCE, ALSO SHOWING ESCOLTA AVENUE AT RIGHT, LOOKING SOUTHEAST FROM RESERVOIR HILL. (Part 2 of a 3 view panorama; see also CA-2398-4 and CA-2398-6.) - Hamilton Field, East of Nave Drive, Novato, Marin County, CA

  7. Las Rocas Nos Cuentan (Rocks Tell Their Stories)

    ERIC Educational Resources Information Center

    Llerandi-Roman, Pablo A.

    2012-01-01

    Many Earth science lessons today still focus on memorizing the names of rocks and minerals. This led the author to develop a lesson that reveals the fascinating stories told by rocks through the study of their physical properties. He first designed the lesson for Puerto Rican teachers, hence its Spanish title: "Las Rocas Nos Cuentan Su Historia."…

  8. Airfield setting of Facility Nos. 175 and 176, taken from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Airfield setting of Facility Nos. 175 and 176, taken from north end of Ford Island Runway, with landplane hangars on the right - U.S. Naval Base, Pearl Harbor, Landplane Hangar Type, Wasp Boulevard and Gambier Bay Street, Pearl City, Honolulu County, HI

  9. Oblique view of east sides of Facility Nos. 393 and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Oblique view of east sides of Facility Nos. 393 and 394, seen from South Avenue looking down Port Royal Street - U.S. Naval Base, Pearl Harbor, Two-Story Storehouses with Ramps, Port Royal Street between Central and South Avenues, Pearl City, Honolulu County, HI

  10. Building Nos. 92, 381, and 392, view into common courtyard ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Building Nos. 92, 381, and 392, view into common courtyard between 92 (right), 391 (center deep), and 392 (left), view facing west-northwest - U.S. Naval Base, Pearl Harbor, Marine Railway No. 1 Accessories House & Apprentice Welding School, Additions, Intersection of Avenue B & Sixth Street, Pearl City, Honolulu County, HI

  11. Efficient algorithms for multi-file caching

    SciTech Connect

    Otoo, Ekow J.; Rotem, Doron; Seshadri, Sridhar

    2004-03-15

    Multi-File Caching issues arise in applications where a set of jobs are processed and each job requests one or more input files. A given job can only be started if all its input files are preloaded into a disk cache. Examples of applications where Multi-File caching may be required are scientific data mining, bit-sliced indexes, and analysis of sets of vertically partitioned files. The difference between this type of caching and traditional file caching systems is that in this environment, caching and replacement decisions are made based on ''combinations of files (file bundles),'' rather than single files. In this work we propose new algorithms for Multi-File caching and analyze their performance. Extensive simulations are presented to establish the effectiveness of the Multi-File caching algorithm in terms of job response time and job queue length.

  12. Probing the Hydrogen Bonding of the Ferrous–NO Heme Center of nNOS by Pulsed Electron Paramagnetic Resonance

    PubMed Central

    Astashkin, Andrei V.; Chen, Li; Elmore, Bradley O.; Kunwar, Deepak; Miao, Yubin; Li, Huiying; Poulos, Thomas L.; Roman, Linda J.; Feng, Changjian

    2015-01-01

    Oxidation of L-arginine (L-Arg) to nitric oxide (NO) by NO synthase (NOS) takes place at the heme active site. It is of current interest to study structures of the heme species that activates O2 and transforms the substrate. The NOS ferrous–NO complex is a close mimic of the obligatory ferric (hydro)peroxo intermediate in NOS catalysis. In this work, pulsed electron–nuclear double resonance (ENDOR) spectroscopy was used to probe the hydrogen bonding of the NO ligand in the ferrous–NO heme center of neuronal NOS (nNOS) without a substrate and with L-Arg or N-hydroxy-L-arginine (NOHA) substrates. Unexpectedly, no H-bonding interaction connecting the NO ligand to the active site water molecule or the Arg substrate was detected, in contrast to the results obtained by X-ray crystallography for the Arg-bound nNOS heme domain [Li et al. J. Biol. Inorg. Chem. 2006, 11, 753–768]. The nearby exchangeable proton in both the no-substrate and Arg-containing nNOS samples is located outside the H-bonding range and, on the basis of the obtained structural constraints, can belong to the active site water (or OH). On the contrary, in the NOHA-bound sample, the nearby exchangeable hydrogen forms an H-bond with the NO ligand (on the basis of its distance from the NO ligand and a nonzero isotropic hfi constant), but it does not belong to the active site water molecule because the water oxygen atom (detected by 17O ENDOR) is too far. This hydrogen should therefore come from the NOHA substrate, which is in agreement with the X-ray crystallography work [Li et al. Biochemistry 2009, 48, 10246–10254]. The nearby nonexchangeable hydrogen atom assigned as Hɛ of Phe584 was detected in all three samples. This hydrogen atom may have a stabilizing effect on the NO ligand and probably determines its position. PMID:26035438

  13. 78 FR 17394 - Filing via the Internet; Electronic Tariff Filings; Revisions to Electric Quarterly Report Filing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-21

    .... 770, 77 FR 71288 (Nov. 30, 2012), FERC Stats. & Regs. ] 31,338 (cross-referenced at 141 FERC ] 61,120... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Filing via the Internet; Electronic Tariff Filings; Revisions to...

  14. 77 FR 2593 - Self-Regulatory Organizations; NYSE Amex LLC; Notice of Filing and Immediate Effectiveness of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-18

    ...,\\3\\ until July 31, 2012. \\3\\ See Securities Exchange Act Release No. 65089 (August 10, 2011), 76 FR... (June 10, 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS-2010-014; SR-EDGA-2010-01; SR-EDGX- 2010... Release No. 62251 (June 10, 2010), 75 FR 34183 (June 16, 2010) (SR-FINRA-2010-025). See also...

  15. 77 FR 2577 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-18

    ...,\\3\\ until July 31, 2012. \\3\\ See Securities Exchange Act Release No. 65088 (August 10, 2011), 76 FR... (June 10, 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS-2010-014; SR-EDGA-2010-01; SR-EDGX- 2010... Release No. 62251 (June 10, 2010), 75 FR 34183 (June 16, 2010) (SR-FINRA-2010-025). See also...

  16. 78 FR 10649 - Self-Regulatory Organizations; BATS Y-Exchange, Inc.; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-14

    .... 63097 (October 13, 2010), 75 FR 64767 (October 20, 2010) (SR-BYX-2010-002). \\6\\ Securities Exchange Act Release No. 64433 (May 6, 2011), 76 FR 27680 (May 12, 2011) (SR-BYX-2011-011). \\7\\ Securities Exchange Act Release No. 64735 (June 23, 2011), 76 FR 38243 (June 29, 2011) (File Nos. SR-BATS-2011-016; SR-BYX-...

  17. 76 FR 27675 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing of Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-12

    ... Release No. 62252 (June 10, 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS-2010-014; SR-EDGA-2010... Securities Exchange Act Release No. 62251 (June 10, 2010), 75 FR 34183 (June 16, 2010) (SR-FINRA-2010-025..., 2010), 75 FR 34498 (June 17, 2010) (SR-NYSE-2010-45). \\4\\ The Commission approved the addition to...

  18. 76 FR 27683 - Self-Regulatory Organizations; Chicago Stock Exchange, Inc.; Notice of Filing of Proposed Change...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-12

    ... Release No. 62252 (June 10, 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS-2010-014; SR-EDGA-2010... Securities Exchange Act Release No. 62251 (June 10, 2010), 75 FR 34183 (June 16, 2010) (SR-FINRA-2010-025..., 2010), 75 FR 34498 (June 17, 2010) (SR-NYSE-2010-45). \\4\\ The Commission approved the addition to...

  19. 77 FR 30566 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-23

    ... (January 13, 2004), 69 FR 2773 (January 20, 2004) (SR-BSE-2003-17); 49065 (January 13, 2004), 69 FR 2768 (January 20, 2004) (SR-BSE- 2003-04) (``BOXR Order''); and 49068 (January 13, 2004), 69 FR 2775 (January 20, 2004) (SR-BSE-2002-15). See also Release No. 34-58324; 73 FR 46936 (August 7, 2008) (File Nos....

  20. 76 FR 51079 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ... erroneous trade break unless that trade exceeded three, five or ten percent beyond the price that triggered... (June 10, 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS-2010-014; SR-EDGA- 2010-01; SR-EDGX-2010...-NASDAQ- 2010- 061; SR-CHX-2010-10; SR-NSX-2010-05; and SR-CBOE-2010-047); 62251 (June 10, 2010), 75...

  1. Input data for inferring species distributions in Kyphosidae world-wide.

    PubMed

    Knudsen, Steen Wilhelm; Clements, Kendall D

    2016-09-01

    Input data files for inferring the relationship among the family Kyphosidae, as presented in (Knudsen and Clements, 2016) [1], is here provided together with resulting topologies, to allow the reader to explore the topologies in detail. The input data files comprise seven nexus-files with sequence alignments of mtDNA and nDNA markers for performing Bayesian analysis. A matrix of recoded character states inferred from the morphology examined in museum specimens representing Dichistiidae, Girellidae, Kyphosidae, Microcanthidae and Scorpididae, is also provided, and can be used for performing a parsimonious analysis to infer the relationship among these perciform families. The nucleotide input data files comprise both multiple and single representatives of the various species to allow for inference of the relationship among the species in Kyphosidae and between the families closely related to Kyphosidae. The '.xml'-files with various constrained relationships among the families potentially closely related to Kyphosidae are also provided to allow the reader to rerun and explore the results from the stepping-stone analysis. The resulting topologies are supplied in newick-file formats together with input data files for Bayesian analysis, together with '.xml'-files. Re-running the input data files in the appropriate software, will enable the reader to examine log-files and tree-files themselves. PMID:27508256

  2. Input data for inferring species distributions in Kyphosidae world-wide.

    PubMed

    Knudsen, Steen Wilhelm; Clements, Kendall D

    2016-09-01

    Input data files for inferring the relationship among the family Kyphosidae, as presented in (Knudsen and Clements, 2016) [1], is here provided together with resulting topologies, to allow the reader to explore the topologies in detail. The input data files comprise seven nexus-files with sequence alignments of mtDNA and nDNA markers for performing Bayesian analysis. A matrix of recoded character states inferred from the morphology examined in museum specimens representing Dichistiidae, Girellidae, Kyphosidae, Microcanthidae and Scorpididae, is also provided, and can be used for performing a parsimonious analysis to infer the relationship among these perciform families. The nucleotide input data files comprise both multiple and single representatives of the various species to allow for inference of the relationship among the species in Kyphosidae and between the families closely related to Kyphosidae. The '.xml'-files with various constrained relationships among the families potentially closely related to Kyphosidae are also provided to allow the reader to rerun and explore the results from the stepping-stone analysis. The resulting topologies are supplied in newick-file formats together with input data files for Bayesian analysis, together with '.xml'-files. Re-running the input data files in the appropriate software, will enable the reader to examine log-files and tree-files themselves.

  3. Virtual file system for PSDS

    NASA Technical Reports Server (NTRS)

    Runnels, Tyson D.

    1993-01-01

    This is a case study. It deals with the use of a 'virtual file system' (VFS) for Boeing's UNIX-based Product Standards Data System (PSDS). One of the objectives of PSDS is to store digital standards documents. The file-storage requirements are that the files must be rapidly accessible, stored for long periods of time - as though they were paper, protected from disaster, and accumulative to about 80 billion characters (80 gigabytes). This volume of data will be approached in the first two years of the project's operation. The approach chosen is to install a hierarchical file migration system using optical disk cartridges. Files are migrated from high-performance media to lower performance optical media based on a least-frequency-used algorithm. The optical media are less expensive per character stored and are removable. Vital statistics about the removable optical disk cartridges are maintained in a database. The assembly of hardware and software acts as a single virtual file system transparent to the PSDS user. The files are copied to 'backup-and-recover' media whose vital statistics are also stored in the database. Seventeen months into operation, PSDS is storing 49 gigabytes. A number of operational and performance problems were overcome. Costs are under control. New and/or alternative uses for the VFS are being considered.

  4. Hypercholesterolemia-induced erectile dysfunction: endothelial nitric oxide synthase (eNOS) uncoupling in the mouse penis by NAD(P)H oxidase

    PubMed Central

    Musicki, Biljana; Liu, Tongyun; Lagoda, Gwen A.; Strong, Travis D.; Sezen, Sena F.; Johnson, Justin M.; Burnett, Arthur L.

    2010-01-01

    INTRODUCTION Hypercholesterolemia induces erectile dysfunction (ED) mostly by increasing oxidative stress and impairing endothelial function in the penis, but the mechanisms regulating reactive oxygen species (ROS) production in the penis are not understood. AIMS We evaluated whether hypercholesterolemia activates nicotinamide adenine dinucleotide phosphate (NAD[P]H) oxidase in the penis, providing an initial source of ROS to induce endothelial nitric oxide synthase (eNOS) uncoupling and endothelial dysfunction resulting in ED. METHODS Low-density-lipoprotein receptor (LDLR)–null mice were fed Western diet for 4 weeks to induce early-stage hyperlipidemia. Wild type (WT) mice fed regular chow served as controls. Mice received NAD(P)H oxidase inhibitor apocynin (10 mM in drinking water) or vehicle. Erectile function was assessed in response to cavernous nerve electrical stimulation. Markers of endothelial function (phospho [P]-vasodilator-stimulated-protein [VASP]-Ser-239), oxidative stress (4-hydroxy-2-nonenal [HNE]), sources of ROS (eNOS uncoupling and NAD[P]H oxidase subunits p67phox, p47phox, and gp91phox), P-eNOS-Ser-1177, and eNOS were measured by Western blot in penes. MAIN OUTCOME MEASURES Molecular mechanisms of ROS generation and endothelial dysfunction in hypercholesterolemia-induced ED. RESULTS Erectile response was significantly (P<0.05) reduced in hypercholesterolemic LDLR-null mice compared to WT mice. Relative to WT mice, hypercholesterolemia increased (P<0.05) protein expressions of NAD(P)H oxidase subunits p67phox, p47phox and gp91phox, eNOS uncoupling, and 4-HNE-modified proteins, and reduced (P<0.05) P-VASP-Ser-239 expression in the penis. Apocynin treatment of LDLR-null mice preserved (P<0.05) maximal intracavernosal pressure, and reversed (P < 0.05) the abnormalities in protein expressions of gp67phox and gp47phox, 4-HNE, P-VASP-Ser-239, and eNOS uncoupling in the penis. Apocynin treatment of WT mice did not affect any of these parameters

  5. 12 CFR 303.201 - Filing procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Filing procedures. 303.201 Section 303.201 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE FILING PROCEDURES Prompt Corrective Action § 303.201 Filing procedures. Applications shall be filed with...

  6. 12 CFR 303.21 - Filing procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE FILING PROCEDURES Deposit Insurance § 303.21 Filing procedures. (a) Applications for deposit insurance shall be filed with.... (b) An application for deposit insurance for an interim depository institution shall be filed...

  7. 12 CFR 303.21 - Filing procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE FILING PROCEDURES Deposit Insurance § 303.21 Filing procedures. (a) Applications for deposit insurance shall be filed with.... (b) An application for deposit insurance for an interim depository institution shall be filed...

  8. 12 CFR 303.201 - Filing procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Filing procedures. 303.201 Section 303.201 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE FILING PROCEDURES Prompt Corrective Action § 303.201 Filing procedures. Applications shall be filed with...

  9. 77 FR 61587 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-10

    ..., LLC. Description: 2012 Fuel Tracker Filing to be effective 11/1/2012. Filed Date: 10/1/12. Accession...-5380. Comments Due: 5 p.m. ET 10/15/12. Docket Numbers: RP13-86-000. Applicants: Southern Star Central.... Description: Fuel Tracker Filing October 1, 2012 to be effective 11/1/2012. Filed Date: 10/1/12....

  10. 76 FR 52652 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-23

    ... Gas Company submits tariff filing per 154.204: DPA Definition Changes to be effective 9/14/2011. Filed.... Description: Carolina Gas Transmission Corporation submits tariff filing per 154.402: 2011 Annual Charge... KPC Pipeline, LLC. Description: PostRock KPC Pipeline, LLC submits tariff filing per 154.313:...

  11. 76 FR 12950 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-09

    ...: ANR Pipeline Company. Description: ANR Pipeline Company submits tariff filing per 154.403(d)(2): Fuel...: Cimarron River Pipeline, LLC. Description: Cimarron River Pipeline, LLC submits tariff filing per 154.403(d... tariff filing per 154.203: Compliance with CP09-17-000 to be effective 4/1/ 2011. Filed Date:...

  12. 18 CFR 1308.27 - Appeal files.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Appeal files. 1308.27... Board of Contract Appeals § 1308.27 Appeal files. (a) Notices of appeal shall be filed as provided in... an appeal file consisting of: (1) The Contracting Officer's decision, if any, from which the...

  13. 50 CFR 20.155 - Public file.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Public file. 20.155 Section 20.155... § 20.155 Public file. (a) Establishment. A public file will be established for each rulemaking to which.... 552, a public file established pursuant to paragraph (a) of this section will contain: (1) The...

  14. 48 CFR 1404.802 - Contract files.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract files. 1404.802 Section 1404.802 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR GENERAL ADMINISTRATIVE MATTERS Contract Files 1404.802 Contract files. In addition to the requirements in FAR 4.802, files...

  15. 10 CFR 603.1020 - File documents.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false File documents. 603.1020 Section 603.1020 Energy... Reporting Information About the Award § 603.1020 File documents. The award file should include an analysis..., the file must document the analysis required (see § 603.560) to set the fixed level of Federal...

  16. 48 CFR 204.802 - Contract files.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract files. 204.802... OF DEFENSE GENERAL ADMINISTRATIVE MATTERS Contract Files 204.802 Contract files. Official contract files shall consist of— (1) Only original, authenticated or conformed copies of contractual...

  17. 47 CFR 1.1704 - Station files.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Station files. 1.1704 Section 1.1704... System (COALS) § 1.1704 Station files. Applications, notifications, correspondence, electronic filings.... These files constitute the official records for these stations and supersede any other records,...

  18. 78 FR 716 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-04

    ... Accounting Report filing on 12/28/12 to be effective N/A. Filed Date: 12/28/12. Accession Number: 20121228.... Description: Environmental Filing 2012 to be effective 2/1/2013. Filed Date: 12/28/12. Accession...

  19. 78 FR 20908 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-08

    ... Numbers: RP13-725-000. Applicants: Panhandle Eastern Pipe Line Company, LP. Description: Flow Through of Cash-Out Revenues filed on 3-28-13. Filed Date: 3/28/13. Accession Number: 20130328-5022. Comments Due.... Description: Flow Through of Penalty Revenues Report filed on 3-28- 13. Filed Date: 3/28/13. Accession...

  20. 77 FR 27044 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-08

    ...: Sabine Pipe Line LLC. Description: Sabine Tariff Filing to be effective 6/1/2012. Filed Date: 4/30/12...: Sabine Pipe Line LLC. Description: Sabine Tariff Filing to be effective 6/1/2012. Filed Date: 4/30/12...: Sabine Pipe Line LLC. Description: Sabine Revises its Forms of Service Agreements to be effective...

  1. 77 FR 68760 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-16

    ... following Natural Gas Pipeline Rate and Refund Report filings: Filings Instituting Proceedings Docket...-001. ] Applicants: El Paso Natural Gas Company, L.L.C. Description: Non-Conforming Agreement Amendment.... Description: NWP NAESB 2.0 Compliance Filing--Second Substitute Sheet to be effective 12/1/2012. Filed...

  2. 75 FR 65469 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-25

    ... be effective 11/8/2010. Filed Date: 10/13/2010. Accession Number: 20101013-5089. Comment Date: 5 p.m... 2 to be effective 12/1/2010. Filed Date: 10/13/2010. Accession Number: 20101013-5094. Comment Date...-434-000 Latigo Compliance Filing to be effective 10/ 1/2010. Filed Date: 10/13/2010. Accession...

  3. 75 FR 6184 - Endangered Species; File No. 14754

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-08

    ... Dr. Isaac Wirgin of the New York University School of Medicine, Department of Environmental Medicine.... ACTION: Notice; receipt of application. SUMMARY: Notice is hereby given that Isaac Wirgin, PhD, New York University School of Medicine, Department of Environmental Medicine, Tuxedo, NY 10987, has applied in...

  4. 75 FR 19363 - Endangered Species; File No. 14754

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-14

    .... ACTION: Issuance of permit. SUMMARY: Notice is hereby given that Isaac Wirgin, PhD, New York University School of Medicine, Department of Environmental Medicine, Tuxedo, NY 10987, has been issued a permit to... Federal Register (75 FR 6184) that a request for a scientific research permit to take shortnose...

  5. 77 FR 27718 - Endangered Species; File No. 15566

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-11

    ... published in the Federal Register (76 FR 78890) that a modification of Permit No. 15566 had been requested... No. 15566, issued April 8, 2011 (76 FR 22877), authorizes capture by trawl of 345 loggerhead (Caretta..., size distributions, sex and genetic ratios, and health of sea turtles. Captures occur annually...

  6. 76 FR 78890 - Endangered Species; File No. 15566

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-20

    ... to Permit No. 15566, issued on April 8, 2011 (76 FR 22877), is requested under the authority of the... in order to assess temporal change in catch rates, size distributions, sex and genetic ratios,...

  7. 77 FR 54566 - Endangered Species; File No. 16134

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-05

    .... SUPPLEMENTARY INFORMATION: On December 9, 2011, notice was published in the Federal Register (76 FR 76950) that... distribution, sex ratio, health parameters and genetic diversity of loggerhead and Kemp's ridley sea turtles...

  8. 76 FR 20324 - Endangered Species; File No. 15606

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ... INFORMATION: On November 24, 2010, notice was published in the Federal Register (75 FR 71670) that a request... University at Galveston, Department of Marine Biology, 5007 Avenue U, Galveston, TX 77553, has been issued...

  9. 76 FR 45517 - Endangered Species; File No. 13330-01

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-29

    ... in the Federal Register (76 FR 14650) that a scientific research permit modification to take... tags, Passive Integrated Transponder (PIT) tags, acoustic tags (transmitters), Pop-Up Archival... replace plastic rototags used to secure VEMCO acoustic transmitters with neoprene clasp tags; and...

  10. 75 FR 67682 - Endangered Species; File No. 15566

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-03

    ... purpose of this research is to assess temporal change in catch rates, size distributions, sex and genetic.... Augustine, FL. Turtles would be handled, blood sampled, measured, flipper and passive integrated...

  11. 78 FR 50396 - Endangered Species; File No. 17405

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-19

    ... Register (78 FR 14078) that a request for a scientific research permit to take black abalone had been... spawning, increased fertilization, increased settlement, and recruitment). No black abalone will be...

  12. 67 FR 63078 - Endangered Species; File No. 1360

    Federal Register 2010, 2011, 2012, 2013, 2014

    2002-10-10

    ..., University of Maryland Center for Environmental Science, P.O. Box 38, Solomons, Maryland 20619 has been... Federal Register (67 FR 3165) that a request for a scientific research permit to take shortnose...

  13. 78 FR 15706 - Endangered Species; File No. 17316

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-12

    ... INFORMATION: On September 24, 2012, notice was published in the Federal Register (77 FR 58812) that a request... tagged, tissue, muscle, and blood sampled, and released. Dead sawfish acquired through strandings or...

  14. 75 FR 11863 - Endangered Species; File No. 15135

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... endangered sea turtles for purposes of scientific research. DATES: Written, telefaxed, or e-mail comments... promise for reducing sea turtle bycatch in another location. Two contracted commercial gillnet vessels..., photographed, and flipper and PIT tagged. Captured sea turtles would be examined for any possible...

  15. 76 FR 23305 - Endangered Species; File No. 15672

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-26

    ... permit to take leatherback sea turtles (Dermochelys coriacea) for purposes of scientific research. DATES... characterize the distribution, movements and dive behavior of leatherback sea turtles in the waters of New... leatherback sea turtles annually. Researchers would use animals that have been disentangled from fishing...

  16. 76 FR 33245 - Endangered Species; File No. 15135

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-08

    ... Register (75 FR 11863) that a request for a scientific research permit to take sea turtles had been... Isle, NC 28594, has been issued a permit to take threatened and endangered sea turtles for purposes... determine if gear modifications can eliminate or reduce sea turtle bycatch. Two contracted...

  17. 77 FR 37877 - Endangered Species; File No. 17022

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-25

    ... permit to take green (Chelonia mydas) and hawksbill (Eretmochelys imbricata) sea turtles for purposes of... permit to continue long- term monitoring of the status of green and hawksbill sea turtles in the remote U... migration routes for green and hawksbill sea turtles. Researchers would capture, examine, measure,...

  18. 75 FR 60734 - Endangered Species; File No. 13599-01

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-01

    ... East-West Highway, Room 13705, Silver Spring, MD 20910; phone (301) 713-2289; fax (301) 713-0376; and Southeast Region, NMFS, 263 13th Ave South, St. Petersburg, FL 33701; phone (727) 824-5312; fax (727) 824.... SUPPLEMENTARY INFORMATION: On May 25, 2010, notice was published in the Federal Register (75 FR 29316) that...

  19. 75 FR 26715 - Endangered Species; File No. 10022

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ... INFORMATION: On September 30, 2009, notice was published in the Federal Register (74 FR 50172) that a modification of Permit No. 10022, issued April 23, 2008 (73 FR 23195), had been requested by the above-named..., Department of Wildlife Ecology and Conservation, University of Florida, P.O. Box 110485, Gainesville,...

  20. 78 FR 22239 - Endangered Species; File No. 16556

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    .... SUPPLEMENTARY INFORMATION: On May 29, 2012, notice was published in the Federal Register (77 FR 31586) that a... (NEFSC; Responsible Party: Dr. William Karp), 166 Water St., Woods Hole, MA 02543 has been issued...

  1. 77 FR 73024 - Endangered Species; File No. 16547-01

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-07

    ... requested a modification to scientific research Permit No. 16547 authorizing scientific research on... Permit No. 16547, issued on April 11, 2012 (77 FR 21754), is requested under the authority of...

  2. 78 FR 19217 - Endangered Species; File No. 16547-01

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    .... SUPPLEMENTARY INFORMATION: On December 7, 2012, notice was published in the Federal Register (77 FR 73024) that... above and below 22 parts per thousand salinity. Researchers are currently authorized to capture adult... telemetry tags dependent on the life stage (adult, sub-adult and juvenile) and the salinity level...

  3. 77 FR 40588 - Endangered Species; File No. 16598

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-10

    ... (Eretmochelys imbricata), and Kemp's ridley (Lepidochelys kempii) sea turtles for purposes of scientific... movements of green, loggerhead, hawksbill, and Kemp's ridley sea turtles in the Key West National Wildlife... turtle abundance, size frequencies, and sex ratios; (2) determine the genetic origin of sea...

  4. 75 FR 9868 - Endangered Species; File No. 14622

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ... (Eretmochelys imbricata), Kemp's ridley (Lepidochelys kempii), and loggerhead (Caretta caretta) sea turtles for... research permit to: (1) monitor the abundance of loggerhead and green sea turtles; (2) characterize the aggregations of loggerhead, Kemp's ridley, and hawksbill sea turtles; and (3) determine the...

  5. 78 FR 44096 - Endangered Species; File No. 17381

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... a permit to take listed sea turtles for purposes of scientific research. ADDRESSES: The permit and...), and Kemp's ridley (Lepidochelys kempii) sea turtles had been submitted by the above-named individual..., loggerhead, hawksbill, and Kemp's ridley sea turtles in Florida waters. Researchers may capture sea...

  6. 78 FR 59657 - Endangered Species; File No. 17304

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-27

    ... mydas) sea turtles for purposes of scientific research. ADDRESSES: The permit and related documents are..., green, hawksbill, and Kemp's ridley sea turtles had been submitted by the above-named individual. The... 100 green, 100 loggerhead, 90 Kemp's ridley, and 20 hawksbill sea turtles annually by hand or...

  7. 77 FR 39220 - Endangered Species; File No. 17183

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-02

    ... Kemp's ridley sea turtles off the northwest coast of Florida. The objectives of the research are to (1) obtain information on sea turtle ecology and health status; (2) determine the genetic origin of sea... broad-scale temporal and spatial patterns of sea turtle use and movement patterns. Researchers...

  8. 77 FR 13096 - Endangered Species; File No. 16598

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-05

    ...), hawksbill (Eretmochelys imbricata), and Kemp's ridley (Lepidochelys kempii) sea turtles for scientific... ridley sea turtles in the Key West National Wildlife Refuge and extend this work to an additional study... turtle abundance, size frequencies, and sex ratios; (2) determine the genetic origin of sea...

  9. 75 FR 71670 - Endangered Species; File No. 15606

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-24

    ...), loggerhead (Caretta caretta), and hawksbill (Eretmochelys imbricata) sea turtles for purposes of scientific... (50 CFR 222-226). Dr. Landry requests a five-year permit to take sea turtles for scientific research in Gulf of Mexico waters. The purposes of these projects are to: (1) Examine green sea...

  10. 78 FR 16255 - Endangered Species; File No. 17022

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-14

    ... (77 FR 37877) that a request for a scientific research permit to take green and hawksbill sea turtles... (Chelonia mydas) and hawksbill (Eretmochelys imbricata) sea turtles for purposes of scientific research... 222-226). The PIFSC is authorized to begin long-term monitoring of green and hawksbill sea turtles...

  11. 78 FR 31519 - Endangered Species; File No. 13543

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-24

    ..., measure, weigh, affix a passive integrated transponder tag, flipper tag, and photograph sea turtles that... history of sea turtles. The permit modification, No. 13543-01 authorizes the requested increase in annual take limits for Kemp's ridley (Lepidochelys kempii) and loggerhead (Caretta caretta) sea turtles...

  12. 77 FR 67341 - Endangered Species; File No. 15809

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-09

    ... applicant requests a 5-year permit to conduct research on green and hawksbill sea turtles around protected... ecological movements of juvenile green and hawksbill sea turtles. Researchers would directly capture up to 40 adult, subadult, or juvenile green sea turtles using tangle nets and up to 40 juvenile and...

  13. 76 FR 6118 - Endangered Species; File No. 14726

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    ... coriacea) sea turtles, to quantify threats to pelagic sea turtles, and to gather information on their life..., flipper and passive integrated transponder tag, measure, weigh, and oral swab sea turtles. A subset of... modification to the permit to: (1) Increase the number and life stages of sea turtles (up to 600...

  14. 78 FR 57353 - Endangered Species; File No. 14726

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-18

    ... (Lepidochelys kempii), hawksbill (Eretmochelys imbricata), and leatherback (Dermochelys coriacea) sea turtles, to quantify threats to pelagic sea turtles, and to gather information on their life-history, genetics... integrated transponder tag, measure, weigh, and oral swab sea turtles. A subset of animals may be...

  15. 78 FR 38013 - Endangered Species; File No. 15661

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-25

    ...) sea turtles in the Northern Mariana Islands (NMI). Authorized research consists of counts and hand captures of sea turtles during vessel surveys. Captured sea turtles may be measured, weighed, flipper and... subset of the turtles may be satellite tagged before release and then tracked from the vessel. Sea...

  16. 75 FR 13255 - Endangered Species; File No. 15338

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-19

    ... appointment in the following office: Marine Mammal and Sea Turtle Conservation Division, Office of Protected... conservation plan includes limiting sampling effort in areas and times where sea turtles are likely to be... take of ESA-listed sea turtles and shortnose sturgeon associated with otherwise lawful research...

  17. 76 FR 22877 - Endangered Species; File No. 15566

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-25

    ... coriacea), and hawksbill (Eretmochelys imbricata) sea turtles for purposes of scientific research... a request for a scientific research permit to take sea turtles had been submitted by the applicant... health of sea turtles. Captures would occur annually in coastal waters between Winyah Bay, SC and...

  18. 76 FR 58471 - Endangered Species; File No. 15634

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-21

    ... permit to take leatherback sea turtles (Dermochelys coriacea) for scientific research. DATES: Written... proposes to conduct research on leatherback sea turtles to continue long-term monitoring of their status... leatherbacks. Up to 55 sea turtles would be located annually through aerial surveys and subsequently...

  19. 77 FR 58812 - Endangered Species; File No. 16733

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-24

    ... olive ridley (L. olivacea) sea turtles for purposes of scientific research. DATES: Written, telefaxed..., loggerhead, green, hawksbill, olive ridley, and Kemp's ridley sea turtles in the North Atlantic Ocean, Gulf... Conservation Division, Office of Protected Resources, NMFS, 1315 East-West Highway, Room 13705, Silver...

  20. 76 FR 22677 - Endangered Species; File No. 14949

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-22

    ... Federal Register (75 FR 13488) that a request for a scientific research permit to take green and hawksbill... Archipelago, and the Tres Palmas reserve. In addition, researchers would monitor the prevalence...

  1. 76 FR 40699 - Endangered Species; File No. 16229

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-11

    .... ACTION: Notice; receipt of application. SUMMARY: Notice is hereby given that the North Carolina Zoo, 4401 Zoo Parkway, Asheboro, NC 27203 , has applied in due form for a permit to hold and transport shortnose... North Carolina Zoo is requesting a permit to continue enhancement activities previously authorized...

  2. 77 FR 10724 - Endangered Species; File No. 16253

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-23

    ..., Gulf of Mexico, Caribbean Sea and their estuarine and coastal environments. The purpose of the research... (Dermochelys coriacea), olive ridley (L. olivacea), and loggerhead (Caretta caretta) sea turtles for scientific.... SUPPLEMENTARY INFORMATION: On June 27, 2011, notice was published in the Federal Register (76 FR 37327) that...

  3. 76 FR 48806 - Endangered Species; File No. 16194

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-09

    ..., hawksbill, leatherback, Kemp's ridley, olive ridley, and unidentified hardshell sea turtles during SEFSC resource assessment cruises in the Gulf of Mexico, the Atlantic Ocean and the Caribbean Sea. Green... ridley (Lepidochelys olivacea), leatherback (Dermochelys coriacea), and unidentified hardshell...

  4. 76 FR 45781 - Endangered Species; File No. 15552

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-01

    ... Ocean, the Gulf of Mexico, the Caribbean Sea, and their tributaries. These efforts would aid in the... coriacea), and ] unidentified hardshell sea turtles for the purposes of scientific research. ADDRESSES: The... INFORMATION: On January 26, 2011, notice was published in the Federal Register (76 FR 4636) that a request...

  5. 77 FR 1671 - Endangered Species; File No. 16194

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-11

    ... Atlantic Ocean, the Gulf of Mexico, the Caribbean Sea, and their embayments and estuaries. This research... unidentified hardshell sea turtles for the purposes of scientific research. ADDRESSES: The permit and related..., 2011, notice was published in the ] Federal Register (76 FR 48806) that a request for a...

  6. 76 FR 37327 - Endangered Species; File No. 16253

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-27

    ..., loggerhead, green, hawksbill, olive ridley, and Kemp's ridley sea turtles in the Atlantic Ocean, Gulf of Mexico, Caribbean Sea and their tributaries. The purpose of the research is to evaluate modifications to...), leatherback (Dermochelys coriacea), olive ridley (Lepidochelys olivacea), and loggerhead (Caretta caretta)...

  7. 78 FR 51712 - Endangered Species; File No. 16733

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-21

    ..., Caribbean Sea and their embayments. Sea turtles may be directly captured by hand or using nets or...), hawksbill (Eretmochelys imbricata), leatherback (Dermochelys coriacea), and olive ridley (L. olivacea) sea... published in the Federal Register (77 FR 58812) that a request for a scientific research permit to...

  8. 78 FR 14078 - Endangered Species; File No. 17405

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-04

    ..., San Diego, CA 92152 has applied in due form for a permit to take black abalone (Haliotis cracherodii... endangered black abalone (focusing on successful spawning, increased fertilization, increased settlement, and recruitment). No black abalone will be taken from the wild, nor will animals be returned to the wild...

  9. 76 FR 71515 - Endangered Species; File No. 16174

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-18

    ..., 2011, notice was published in the Federal Register (76 FR 18725) that a request for a scientific.... ACTION: Issuance of permit. SUMMARY: Notice is hereby given that Michael Salmon, Ph.D., Florida Atlantic... of the ESA. Dated: November 14, 2011. P. Michael Payne, Chief, Permits and Conservation...

  10. 76 FR 4635 - Endangered Species; File No. 15552

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-26

    ...), loggerhead (Caretta caretta), Kemp's ridley (Lepidochelys kempii), olive ridley (Lepidochelys olivacea..., loggerhead, hawksbill, leatherback, Kemp's ridley, olive ridley, and unidentified hardshell sea turtles by... 120 olive ridley/ unknown hardshell sea turtles would be handled, identified, photographed,...

  11. 75 FR 53278 - Endangered Species; File No. 14759

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-31

    .... SUPPLEMENTARY INFORMATION: On March 12, 2010, notice was published in the Federal Register (75 FR 11862) that a... sturgeon in North Carolina rivers (Chowan, Roanoke, and Cape Fear) and estuaries (Albemarle Sound). The... annually from the Chowan and Cape Fear River Basins and Albemarle Sound. Similar activities capturing up...

  12. 75 FR 4043 - Endangered Species; File No. 14396

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-26

    ... Register (74 FR 42861) that a request for a scientific research permit to take shortnose sturgeon had been... take shortnose sturgeon (Acipenser brevirostrum) for purposes of scientific research. ADDRESSES: The... applicant is authorized to conduct a five-year scientific study of shortnose sturgeon in the Delaware...

  13. 21 CFR 516.163 - Change in ownership of an index file.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS NEW ANIMAL DRUGS FOR MINOR USE AND MINOR SPECIES Index of Legally Marketed Unapproved New Animal Drugs for Minor Species § 516.163 Change in ownership of an... owner shall submit in writing to FDA a statement that all rights in the index file have been...

  14. 21 CFR 516.163 - Change in ownership of an index file.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS NEW ANIMAL DRUGS FOR MINOR USE AND MINOR SPECIES Index of Legally Marketed Unapproved New Animal Drugs for Minor Species § 516.163 Change in ownership of an... owner shall submit in writing to FDA a statement that all rights in the index file have been...

  15. Endothelial nitric oxide synthase: From biochemistry and gene structure to clinical implications of NOS3 polymorphisms.

    PubMed

    Oliveira-Paula, Gustavo H; Lacchini, Riccardo; Tanus-Santos, Jose E

    2016-01-10

    Nitric oxide (NO) is an important vasodilator with a well-established role in cardiovascular homeostasis. While mediator is synthesized from L-arginine by neuronal, endothelial, and inducible nitric oxide synthases (NOS1,NOS3 and NOS2 respectively), NOS3 is the most important isoform for NO formation in the cardiovascular system. NOS3 is a dimeric enzyme whose expression and activity are regulated at transcriptional, posttranscriptional,and posttranslational levels. The NOS3 gene, which encodes NOS3, exhibits a number of polymorphic sites including single nucleotide polymorphisms (SNPs), variable number of tandem repeats (VNTRs), microsatellites, and insertions/deletions. Some NOS3 polymorphisms show functional effects on NOS3 expression or activity, thereby affecting NO formation. Interestingly, many studies have evaluated the effects of functional NOS3 polymorphisms on disease susceptibility and drug responses. Moreover, some studies have investigated how NOS3 haplotypes may impact endogenous NO formation and disease susceptibility. In this article,we carried out a comprehensive review to provide a basic understanding of biochemical mechanisms involved in NOS3 regulation and how genetic variations in NOS3 may translate into relevant clinical and pharmacogenetic implications. PMID:26428312

  16. Endothelial nitric oxide synthase: From biochemistry and gene structure to clinical implications of NOS3 polymorphisms.

    PubMed

    Oliveira-Paula, Gustavo H; Lacchini, Riccardo; Tanus-Santos, Jose E

    2016-01-10

    Nitric oxide (NO) is an important vasodilator with a well-established role in cardiovascular homeostasis. While mediator is synthesized from L-arginine by neuronal, endothelial, and inducible nitric oxide synthases (NOS1,NOS3 and NOS2 respectively), NOS3 is the most important isoform for NO formation in the cardiovascular system. NOS3 is a dimeric enzyme whose expression and activity are regulated at transcriptional, posttranscriptional,and posttranslational levels. The NOS3 gene, which encodes NOS3, exhibits a number of polymorphic sites including single nucleotide polymorphisms (SNPs), variable number of tandem repeats (VNTRs), microsatellites, and insertions/deletions. Some NOS3 polymorphisms show functional effects on NOS3 expression or activity, thereby affecting NO formation. Interestingly, many studies have evaluated the effects of functional NOS3 polymorphisms on disease susceptibility and drug responses. Moreover, some studies have investigated how NOS3 haplotypes may impact endogenous NO formation and disease susceptibility. In this article,we carried out a comprehensive review to provide a basic understanding of biochemical mechanisms involved in NOS3 regulation and how genetic variations in NOS3 may translate into relevant clinical and pharmacogenetic implications.

  17. Association of NOS2 and NOS3 gene polymorphisms with susceptibility to type 2 diabetes mellitus and diabetic nephropathy in the Chinese Han population.

    PubMed

    Chen, Feng; Li, Yu-Mei; Yang, Lin-Qing; Zhong, Cai-Gao; Zhuang, Zhi-Xiong

    2016-07-01

    Inducible nitric oxide synthase (NOS2) and endothelial nitric oxide synthase (NOS3) gene play important roles in the susceptibility to type 2 diabetes mellitus (T2DM). The present study aims to detect the potential association of NOS2 and NOS3 gene polymorphisms with the susceptibility toT2DM and diabetic nephropathy (DN) in the Chinese Han population. Four hundred and ninety T2DM patients and 485 healthy controls were enrolled in this case-control study. The genotypes of NOS2 and NOS3 gene polymorphisms were analyzed by the polymerase chain reaction (PCR)-ligase detection reaction (LDR) method. Our data demonstrated that the NOS2 rs2779248 and NOS2 rs1137933 genetic polymorphisms were significantly associated with the increased susceptibility to T2DM in the heterozygote comparison, dominant model, and allele contrast; and NOS3 rs3918188 genetic polymorphism was significantly associated with the increased susceptibility to T2DM in the homozygote comparison and recessive model. The allele-C and genotype-TC of NOS2 rs2779248, allele-A and genotype-GA of NOS2 rs1137933 and genotype-AA of NOS3 rs3918188 genetic polymorphisms might be the risk factors for increasing the susceptibility to T2DM. And a significant haplotype effect of NOS2 rs10459953/C- rs1137933/G- rs2779248/T was found between T2DM cases and controls. Moreover, NOS3 rs1800783 polymorphism was significantly associated with the increased susceptibility to DN in the heterozygote comparison, recessive model and allele contrast. At last, a positive correlation of family history of diabetes with NOS3 rs11771443 polymorphism was found in DN. These preliminary findings indicate that the NOS2 rs2779248, NOS2 rs1137933, and NOS3 rs3918188 genetic polymorphisms are potentially related to the susceptibility to T2DM, and the rs1800783 polymorphism might be considered as genetic risk factors for diabetic nephropathy, and family history of diabetes was closely associated with rs11771443 polymorphism in DN, and the

  18. Hazardous Material Data File (HMDF), quarterly update. Data file

    SciTech Connect

    Not Available

    1993-03-01

    The Hazardous Materiel Data File (HMDF) purpose is to provide storage and transportation information on chemical, radioactive and ammunition items in the Army inventory. Data is taken from the Army Central Logistics Data Bank (ACLDB).

  19. Hazardous Materiel Data File (HMDF), quarterly update. Data file

    SciTech Connect

    Not Available

    1990-05-01

    The Hazardous Materiel Data File (HMDF) purpose is to provide storage and transportation information on chemical, radioactive and ammunition items in the Army inventory. Data are taken from the Army Central Logistics Data Bank (ACLDB).

  20. Formation of nNOS/PSD-95 PDZ dimer requires a preformed beta-finger structure from the nNOS PDZ domain.

    PubMed

    Tochio, H; Mok, Y K; Zhang, Q; Kan, H M; Bredt, D S; Zhang, M

    2000-10-27

    PDZ domains are modular protein units that play important roles in organizing signal transduction complexes. PDZ domains mediate interactions with both C-terminal peptide ligands and other PDZ domains. Here, we used PDZ domains from neuronal nitric oxide synthase (nNOS) and postsynaptic density protein-95 (PSD-95) to explore the mechanism for PDZ-dimer formation. The nNOS PDZ domain terminates with a approximately 30 residue amino acid beta-finger peptide that is shown to be required for nNOS/PSD-95 PDZ dimer formation. In addition, formation of the PDZ dimer requires this beta-finger peptide to be physically anchored to the main body of the canonical nNOS PDZ domain. A buried salt bridge between the beta-finger and the PDZ domain induces and stabilizes the beta-hairpin structure of the nNOS PDZ domain. In apo-nNOS, the beta-finger peptide is partially flexible and adopts a transient beta-strand like structure that is stabilized upon PDZ dimer formation. The flexibility of the NOS PDZ beta-finger is likely to play a critical role in supporting the formation of nNOS/PSD-95 complex. The experimental data also suggest that nNOS PDZ and the second PDZ domain of PSD-95 form a "head-to-tail" dimer similar to the nNOS/syntrophin complex characterized by X-ray crystallography.

  1. Influence of intravascular low level He-Ne laser irradiation on iNOS, total-NOS, and ET-1 in acute spinal cord-injured rabbits

    NASA Astrophysics Data System (ADS)

    Yin, Zhenchun; Dong, Yinghai; Zhu, Jing

    2005-07-01

    Objective To research the influence of intravascular low level Laser irradiation (ILLLI) on total NOS, iNOS, and ET-1 in spinal cord following acute spinal cord injury (ASCI), and discuss the protective effects of ILLLI on neurons .Methods 72 rabbits were randomly divided into 3 groups: treatment group, injury group and control group. In treatment group and injury group, after laminectomy at the level of T-13, ASCI was performed by using Allen"s method with slight modification (6g×10cm) on rabbits. After injury, rabbits were treated immediately with He-Ne laser (power 5 mW, 1 hour per day for 10 days). At the day of 10th after treatment, total-NOS, iNOS, and ET-1 in spinal cord tissues were measured. Results The expression level of total-NOS, iNOS, and ET-1 in spinal cord in injury group were significantly higher than those in control group (P<0.05), while after ILLLI the level of these index in treatment group decreased statistically significantly compared with those in injury group (P<0.05). Conclusion ILLLI can significantly decrease the expression level of total-NOS, iNOS, and ET-1 in spinal cord. It indicates that ILLLI can relieve the overexpression of total-NOS, iNOS, and ET-1 ,and thus can perform protective effects on neurons in the course of secondary spinal cord injury (SSCI) following ASCI

  2. 47 CFR 61.14 - Method of filing publications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) TARIFFS Rules for Electronic Filing § 61.14 Method of filing publications. (a) Publications filed... Electronic Tariff Filing System will accept filings 24 hours a day, seven days a week. The official filing date of a publication received by the Electronic Tariff Filing System will be determined by the...

  3. 76 FR 62092 - Filing Procedures

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-06

    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE... filed with the Commission, reduce Commission expenditures, and conform agency processes to federal government initiatives. DATES: Effective Date: November 7, 2011. FOR FURTHER INFORMATION CONTACT: James...

  4. 1. Streetscape of north ends of Detention Wards, Building Nos. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Streetscape of north ends of Detention Wards, Building Nos. 9946-B (left) and 9945-B (middle). Walled-in courtyard adjoins Building No. 9944-B at extreme right edge. Steam plant is in distance. This photo makes a panorama with photo WA-202-10-2. - Madigan Hospital, Detention Wards, Bounded by Wilson & McKinley Avenues & Garfield & Lincoln Streets, Tacoma, Pierce County, WA

  5. 38. View of DRS 1, 2, and 3 (structure nos. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    38. View of DRS 1, 2, and 3 (structure nos. 735, 736, and 737) console fault locator for beam power status, radio frequency (RF) and intermediate frequency (IF) fault conditions, RF switches status and TR status. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  6. File servers, networking, and supercomputers

    NASA Technical Reports Server (NTRS)

    Moore, Reagan W.

    1991-01-01

    One of the major tasks of a supercomputer center is managing the massive amount of data generated by application codes. A data flow analysis of the San Diego Supercomputer Center is presented that illustrates the hierarchical data buffering/caching capacity requirements and the associated I/O throughput requirements needed to sustain file service and archival storage. Usage paradigms are examined for both tightly-coupled and loosely-coupled file servers linked to the supercomputer by high-speed networks.

  7. File servers, networking, and supercomputers

    NASA Technical Reports Server (NTRS)

    Moore, Reagan W.

    1992-01-01

    One of the major tasks of a supercomputer center is managing the massive amount of data generated by application codes. A data flow analysis of the San Diego Supercomputer Center is presented that illustrates the hierarchical data buffering/caching capacity requirements and the associated I/O throughput requirements needed to sustain file service and archival storage. Usage paradigms are examined for both tightly-coupled and loosely-coupled file servers linked to the supercomputer by high-speed networks.

  8. Directory of astronomical data files

    NASA Technical Reports Server (NTRS)

    1978-01-01

    This Directory of Astronomical Data Files was prepared by the Data Task Force of the Interagency Coordination Committee for Astronomy (ICCA) in cooperation with the National Space Science Data Center (NSSDC). The purpose of the Directory is to provide a listing which will enable a user to locate stellar and extragalactic data sources keyed along with sufficient descriptive information to permit him to assess the value of the files for his use as well as the status and availability of the compilations.

  9. The secret stridulatory file under the right tegmen in katydids (Orthoptera, Ensifera, Tettigonioidea).

    PubMed

    Chamorro-Rengifo, Juliana; Braun, Holger; Lopes-Andrade, Cristiano

    2014-06-25

    Males of most species of crickets and katydids produce species-specific calling songs to attract conspecific females. The typical stridulatory apparatus of the Ensifera consists of a file-and-scraper system in the basal dorsal region of the forewings (tegmina): the file on the underside of the cubital vein of one tegmen is composed of a series of lamelliform teeth and is run against the sclerotized scraper at the edge of the other tegmen. The region directly distal of the cubital vein is often thin and glassy and serves to amplify and spread the sound. In stridulating crickets the tegmina are quite symmetrical with both the left and the right one containing a file, which is considered the ancestral condition (Béthoux 2012). Most of these crickets adopted a right-over-left wing overlap and use only the right file. The few extant species of the ancient group Hagloidea have bilaterally symmetrical tegmina, both with functional files, and individual males can change the overlap (Morris & Gwynne 1978). Katydids are distinguished by a left-over-right wing overlap, with a stridulatory file on the underside of the left tegmen, and a scraper on the right one, which usually is also equipped with a mirror as resonating structure.

  10. 49 CFR 173.187 - Pyrophoric solids, metals or alloys, n.o.s.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Pyrophoric solids, metals or alloys, n.o.s. 173... Class 1 and Class 7 § 173.187 Pyrophoric solids, metals or alloys, n.o.s. Packagings for pyrophoric solids, metals, or alloys, n.o.s. must conform to the requirements of part 178 of this subchapter at...

  11. 15 CFR Supplement Nos.1-3 to Part 746 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false Nos.1 Supplement Nos.1-3 to Part 746 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF... CONTROLS Supplement Nos.1-3 to Part 746...

  12. 15 CFR Supplement Nos.1-3 to Part 746 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Nos.1 Supplement Nos.1-3 to Part 746 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF... CONTROLS Supplement Nos.1-3 to Part 746...

  13. Expression, localization, and regulation of NOS in human mast cell lines: effects on leukotriene production.

    PubMed

    Gilchrist, Mark; McCauley, Scott D; Befus, A Dean

    2004-07-15

    Nitric oxide (NO) is a potent radical produced by nitric oxide synthase (NOS) and has pleiotrophic activities in health and disease. As mast cells (MCs) play a central role in both homeostasis and pathology, we investigated NOS expression and NO production in human MC populations. Endothelial NOS (eNOS) was ubiquitously expressed in both human MC lines and skin-derived MCs, while neuronal NOS (nNOS) was variably expressed in the MC populations studied. The inducible (iNOS) isoform was not detected in human MCs. Both growth factor-independent (HMC-1) and -dependent (LAD 2) MC lines showed predominant nuclear eNOS protein localization, with weaker cytoplasmic expression. nNOS showed exclusive cytoplasmic localization in HMC-1. Activation with Ca(2+) ionophore (A23187) or IgE-anti-IgE induced eNOS phosphorylation and translocation to the nucleus and nuclear and cytoplasmic NO formation. eNOS colocalizes with the leukotriene (LT)-initiating enzyme 5-lipoxygenase (5-LO) in the MC nucleus. The NO donor, S-nitrosoglutathione (SNOG), inhibited, whereas the NOS inhibitor, N(G)-nitro-l-arginine methyl ester (L-NAME), potentiated LT release in a dose-dependent manner. Thus, human MC lines produce NO in both cytoplasmic and nuclear compartments, and endogenously produced NO can regulate LT production by MCs. PMID:15044250

  14. Growth Hormone Effects in Immune Stress: AKT/eNOS Signaling Module in the Cellular Response

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The activation of the constitutive endothelial nitric-oxide synthase (eNOS) and expression of inducible NOS (iNOS) with subsequent nitric oxide production are among the early cellular responses that follow in a systemic exposure of animals to lipopolysaccharide (LPS). Growth hormone (GH) has been sh...

  15. Exercise does not activate the β3 adrenergic receptor-eNOS pathway, but reduces inducible NOS expression to protect the heart of obese diabetic mice.

    PubMed

    Kleindienst, Adrien; Battault, Sylvain; Belaidi, Elise; Tanguy, Stephane; Rosselin, Marie; Boulghobra, Doria; Meyer, Gregory; Gayrard, Sandrine; Walther, Guillaume; Geny, Bernard; Durand, Gregory; Cazorla, Olivier; Reboul, Cyril

    2016-07-01

    Obesity and diabetes are associated with higher cardiac vulnerability to ischemia-reperfusion (IR). The cardioprotective effect of regular exercise has been attributed to β3-adrenergic receptor (β3AR) stimulation and increased endothelial nitric oxide synthase (eNOS) activation. Here, we evaluated the role of the β3AR-eNOS pathway and NOS isoforms in exercise-induced cardioprotection of C57Bl6 mice fed with high fat and sucrose diet (HFS) for 12 weeks and subjected or not to exercise training during the last 4 weeks (HFS-Ex). HFS animals were more sensitive to in vivo and ex vivo IR injuries than control (normal diet) and HFS-Ex mice. Cardioprotection in HFS-Ex mice was not associated with increased myocardial eNOS activation and NO metabolites storage, possibly due to the β3AR-eNOS pathway functional loss in their heart. Indeed, a selective β3AR agonist (BRL37344) increased eNOS activation and had a protective effect against IR in control, but not in HFS hearts. Moreover, iNOS expression, nitro-oxidative stress (protein s-nitrosylation and nitrotyrosination) and ROS production during early reperfusion were increased in HFS, but not in control mice. Exercise normalized iNOS level and reduced protein s-nitrosylation, nitrotyrosination and ROS production in HFS-Ex hearts during early reperfusion. The iNOS inhibitor 1400 W reduced in vivo infarct size in HFS mice to control levels, supporting the potential role of iNOS normalization in the cardioprotective effects of exercise training in HFS-Ex mice. Although the β3AR-eNOS pathway is defective in the heart of HFS mice, regular exercise can protect their heart against IR by reducing iNOS expression and nitro-oxidative stress. PMID:27164904

  16. DNA evolution and successive file editions

    NASA Astrophysics Data System (ADS)

    Zebende, Gilney F.; Penna, Thadeu J. P.; Oliveira, Paulo Murilo C. de

    Sequences of nucleotides along DNA chains are known to present long range correlations. These correlations are small for simple species (algae) and increase for more complex ones. Scanning DNA chains one finds pieces called exons which are known to code some protein sequence, and others called introns whose usefulness is debatable and do not code protein sequences. By reading only exons (skipping introns), one always gets no correlation at all, in spite of observing a large correlation by reading the whole DNA sequence. The proposed explanation is that introns are fossil DNA parts no longer in use after evolutional replacement by new, better material (current exons). Sucessive editions of the files stored in a diskette follow the same dynamic mechanism proposed for DNA evolution. Current versions of the files play the role of exons, whereas introns correspond to old versions no longer in use (but still partially stored on the disk). We find that correlations indeed increase as more and more editions are performed. This artificial system has the advantage, over real DNA data, of allowing experiments.

  17. Multimedia electronic teaching file

    NASA Astrophysics Data System (ADS)

    Honeyman-Buck, Janice C.; Krishnaprasad, Vidhya; Staab, Edward V.

    1994-05-01

    To make images and data available to all the radiologists, fellows, and residents at the University of Florida an electronic teaching file was required that was accessible to a wide range of people in a number of locations and could display not only data about cases, but the relevant images to go with the case. The multimedia electronic teaching system (METS) uses Oracle as its database management system with addresses of images stored in the tables. To avoid tedious data entry, a connection to the medical center's radiology information system was made. Findings, diagnosis and ACR codes are entered at the data entry screen along with the image numbers of the relevant images for CT, MRI, and US. These images are retrieved from the PACS system for storage on the METS disks. The user interface to the retrieval and display operation allows a search of any or all of the fields in the database through a query by example facility. Simple image manipulation is possible. A Sun workstation was used to implement the system. The user interface was initially written using the MOTIF window manager that could be run over the network on any other Sun workstation. An upgrade uses a MOSAIC with forms to implement data entry and query facilities.

  18. Zebra: A striped network file system

    NASA Technical Reports Server (NTRS)

    Hartman, John H.; Ousterhout, John K.

    1992-01-01

    The design of Zebra, a striped network file system, is presented. Zebra applies ideas from log-structured file system (LFS) and RAID research to network file systems, resulting in a network file system that has scalable performance, uses its servers efficiently even when its applications are using small files, and provides high availability. Zebra stripes file data across multiple servers, so that the file transfer rate is not limited by the performance of a single server. High availability is achieved by maintaining parity information for the file system. If a server fails its contents can be reconstructed using the contents of the remaining servers and the parity information. Zebra differs from existing striped file systems in the way it stripes file data: Zebra does not stripe on a per-file basis; instead it stripes the stream of bytes written by each client. Clients write to the servers in units called stripe fragments, which are analogous to segments in an LFS. Stripe fragments contain file blocks that were written recently, without regard to which file they belong. This method of striping has numerous advantages over per-file striping, including increased server efficiency, efficient parity computation, and elimination of parity update.

  19. The Different Potential of Sponge Bacterial Symbionts in N2 Release Indicated by the Phylogenetic Diversity and Abundance Analyses of Denitrification Genes, nirK and nosZ

    PubMed Central

    Zhang, Xia; He, Liming; Zhang, Fengli; Sun, Wei; Li, Zhiyong

    2013-01-01

    Nitrogen cycle is a critical biogeochemical process of the oceans. The nitrogen fixation by sponge cyanobacteria was early observed. Until recently, sponges were found to be able to release nitrogen gas. However the gene-level evidence for the role of bacterial symbionts from different species sponges in nitrogen gas release is limited. And meanwhile, the quanitative analysis of nitrogen cycle-related genes of sponge microbial symbionts is relatively lacking. The nirK gene encoding nitrite reductase which catalyzes soluble nitrite into gas NO and nosZ gene encoding nitrous oxide reductase which catalyzes N2O into N2 are two key functional genes in the complete denitrification pathway. In this study, using nirK and nosZ genes as markers, the potential of bacterial symbionts in six species of sponges in the release of N2 was investigated by phylogenetic analysis and real-time qPCR. As a result, totally, 2 OTUs of nirK and 5 OTUs of nosZ genes were detected by gene library-based saturated sequencing. Difference phylogenetic diversity of nirK and nosZ genes were observed at OTU level in sponges. Meanwhile, real-time qPCR analysis showed that Xestospongia testudinaria had the highest abundance of nosZ gene, while Cinachyrella sp. had the greatest abundance of nirK gene. Phylogenetic analysis showed that the nirK and nosZ genes were probably of Alpha-, Beta-, and Gammaproteobacteria origin. The results from this study suggest that the denitrification potential of bacteria varies among sponges because of the different phylogenetic diversity and relative abundance of nosZ and nirK genes in sponges. Totally, both the qualitative and quantitative analyses of nirK and nosZ genes indicated the different potential of sponge bacterial symbionts in the release of nitrogen gas. PMID:23762300

  20. SAGE III L2 Solar Event Species Profiles V003 (HDF-EOS)

    Atmospheric Science Data Center

    2016-06-14

    SAGE III L2 Solar Event Species Profiles V003 (HDF-EOS) Project Title:  SAGE ... Temporal Resolution:  1 file per event File Format:  HDF-EOS Tools:  Search ... Air Temperature Trace Gases Dust/ash Aerosol Extinction Order Data:  Earthdata Search: Order Data ...

  1. SAGE III L2 Solar Event Species Profiles (HDF-EOS)

    Atmospheric Science Data Center

    2016-06-14

    SAGE III L2 Solar Event Species Profiles Project Title:  SAGE III ... Temporal Resolution:  1 file per event File Format:  HDF-EOS Tools:  Search ...  |  Data Pool V4 Parameters:  Aerosol Extinction Air Temperature Atmospheric Pressure Dust/ash Nitrogen ...

  2. 75 FR 3263 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing of Amendment Nos. 2...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-20

    ... (January 22, 2009), 74 FR 5193. \\4\\ Letters to Elizabeth M. Murphy, Secretary, Commission, from Harvey... Executive Officer, Lek Securities Corporation, dated June 15, 2009 (``Lek Letter''); letter to David S..., 2009 (``FTEN II Letter''); letter to James Brigagliano, Co-Acting Director, David Shillman,...

  3. 78 FR 78437 - Self-Regulatory Organizations; BOX Options Exchange LLC; Notice of Filing of Amendment Nos. 1 and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-26

    ... (September 17, 2013), 78 FR 58364 (``Notice''). \\4\\ See Securities Exchange Act Release No. 70799 (November 1, 2013), 78 FR 66980 (November 7, 2013). \\5\\ In Amendment No. 1, BOX added further information relating... Securities Exchange Act Release No. 70395 (September 15, 2013), 78 FR 57911 (September 20, 2013)) that...

  4. 75 FR 41264 - Self-Regulatory Organizations; NYSE Amex LLC; Notice of Filing of Amendment Nos. 2 and 3, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-15

    ... Securities Exchange Act Release No. 61890 (April 12, 2010), 75 FR 20401 (``Notice''). II. Description of the...., 75 FR at 20405. D. Integration of NYSE Amex-Listed Securities and Nasdaq Securities at Posts on the... almost exactly as the Exchange's listed securities.\\10\\ \\10\\ See Notice, supra note 3, 75 FR at...

  5. 78 FR 4554 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing of Amendment Nos. 1...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-22

    ... Robert B. Lamm, Chair, Securities Law Committee, The Society of Corporate Secretaries & Governance... corporate governance requirements for companies listed on the Exchange: Rule 5605, ``Boards of Directors and Committees,'' and Rule 5615, ``Exemptions from Certain Corporate Governance Requirements.'' In...

  6. Usage analysis of user files in UNIX

    NASA Technical Reports Server (NTRS)

    Devarakonda, Murthy V.; Iyer, Ravishankar K.

    1987-01-01

    Presented is a user-oriented analysis of short term file usage in a 4.2 BSD UNIX environment. The key aspect of this analysis is a characterization of users and files, which is a departure from the traditional approach of analyzing file references. Two characterization measures are employed: accesses-per-byte (combining fraction of a file referenced and number of references) and file size. This new approach is shown to distinguish differences in files as well as users, which cam be used in efficient file system design, and in creating realistic test workloads for simulations. A multi-stage gamma distribution is shown to closely model the file usage measures. Even though overall file sharing is small, some files belonging to a bulletin board system are accessed by many users, simultaneously and otherwise. Over 50% of users referenced files owned by other users, and over 80% of all files were involved in such references. Based on the differences in files and users, suggestions to improve the system performance were also made.

  7. Nitric oxide synthase (NOS3) variants and disease-free survival among treated and untreated breast cancer patients in a SWOG Clinical Trial (S8897)

    PubMed Central

    Choi, Ji-Yeob; Barlow, William E.; Albain, Kathy S.; Hong, Chi-Chen; Blanco, Javier G.; Livingston, Robert B.; Davis, Warren; Rae, James M.; Yeh, I-Tien; Hutchins, Laura F.; Ravdin, Peter M.; Martino, Silvana; Lyss, Alan P.; Osborne, C. Kent; Abeloff, Martin D.; Hayes, Daniel F.; Ambrosone, Christine B.

    2009-01-01

    Purpose Numerous chemotherapeutic agents are cytotoxic through generation of reactive species, and variability in genes related to oxidative stress may influence disease free survival (DFS). We examined relationships between DFS and variants in NOS3, as well as NQO1, NQO2 and CBR3 among treated and untreated breast cancer patients in a Southwest Oncology Group clinical trial (S8897). Experimental Design In the parent trial, women were assigned according to prognostic features; the high risk group was randomized to CMF or CAF ± tamoxifen, and the low risk group did not receive adjuvant therapy. We extracted DNA from normal lymph node tissue and examined functional polymorphisms in NOS3, NQO1, NQO2 and CBR3, in relation to DFS, using Cox proportional hazard model. Results There were significant interactions between DFS, adjuvant therapy, and NOS3 Glu298Asp and -786 polymorphisms, alone and in combination (p for interaction=0.008). When NOS3 genotypes were combined, women with genotypes encoding for lower NO who received chemotherapy had more than a two fold increase in hazard of progression (HR=2.32, 95% CI=1.26-4.25), while there was reduced risk for those who did not receive adjuvant therapy (HR=0.42, 95% CI=0.19-0.95). There were no associations between the other genotypes and DFS in either group. Conclusion Variants encoding lower activity of NOS3 may affect outcomes in breast cancer patients, with the direction of risk differing depending upon chemotherapy status. These results may mirror the known dual functions of NO and NOS, depending upon oxidative environment. PMID:19671875

  8. Stromal cell-derived factor 2 is critical for Hsp90-dependent eNOS activation.

    PubMed

    Siragusa, Mauro; Fröhlich, Florian; Park, Eon Joo; Schleicher, Michael; Walther, Tobias C; Sessa, William C

    2015-08-18

    Endothelial nitric oxide synthase (eNOS) catalyzes the conversion of l-arginine and molecular oxygen into l-citrulline and nitric oxide (NO), a gaseous second messenger that influences cardiovascular physiology and disease. Several mechanisms regulate eNOS activity and function, including phosphorylation at Ser and Thr residues and protein-protein interactions. Combining a tandem affinity purification approach and mass spectrometry, we identified stromal cell-derived factor 2 (SDF2) as a component of the eNOS macromolecular complex in endothelial cells. SDF2 knockdown impaired agonist-stimulated NO synthesis and decreased the phosphorylation of eNOS at Ser(1177), a key event required for maximal activation of eNOS. Conversely, SDF2 overexpression dose-dependently increased NO synthesis through a mechanism involving Akt and calcium (induced with ionomycin), which increased the phosphorylation of Ser(1177) in eNOS. NO synthesis by iNOS (inducible NOS) and nNOS (neuronal NOS) was also enhanced upon SDF2 overexpression. We found that SDF2 was a client protein of the chaperone protein Hsp90, interacting preferentially with the M domain of Hsp90, which is the same domain that binds to eNOS. In endothelial cells exposed to vascular endothelial growth factor (VEGF), SDF2 was required for the binding of Hsp90 and calmodulin to eNOS, resulting in eNOS phosphorylation and activation. Thus, our data describe a function for SDF2 as a component of the Hsp90-eNOS complex that is critical for signal transduction in endothelial cells. PMID:26286023

  9. Stromal cell–derived factor 2 is critical for Hsp90-dependent eNOS activation

    PubMed Central

    Siragusa, Mauro; Fröhlich, Florian; Park, Eon Joo; Schleicher, Michael; Walther, Tobias C.; Sessa, William C.

    2016-01-01

    Endothelial nitric oxide synthase (eNOS) catalyzes the conversion of l-arginine and molecular oxygen into l-citrulline and nitric oxide (NO), a gaseous second messenger that influences cardiovascular physiology and disease. Several mechanisms regulate eNOS activity and function, including phosphorylation at Ser and Thr residues and protein-protein interactions. Combining a tandem affinity purification approach and mass spectrometry, we identified stromal cell–derived factor 2 (SDF2) as a component of the eNOS macromolecular complex in endothelial cells. SDF2 knockdown impaired agonist-stimulated NO synthesis and decreased the phosphorylation of eNOS at Ser1177, a key event required for maximal activation of eNOS. Conversely, SDF2 overexpression dose-dependently increased NO synthesis through a mechanism involving Akt and calcium (induced with ionomycin), which increased the phosphorylation of Ser1177 in eNOS. NO synthesis by iNOS (inducible NOS) and nNOS (neuronal NOS) was also enhanced upon SDF2 overexpression. We found that SDF2 was a client protein of the chaperone protein Hsp90, interacting preferentially with the M domain of Hsp90, which is the same domain that binds to eNOS. In endothelial cells exposed to vascular endothelial growth factor (VEGF), SDF2 was required for the binding of Hsp90 and calmodulin to eNOS, resulting in eNOS phosphorylation and activation. Thus, our data describe a function for SDF2 as a component of the Hsp90-eNOS complex that is critical for signal transduction in endothelial cells. PMID:26286023

  10. Isolation and chromosomal localization of the human endothelial nitric oxide synthase (NOS3) gene

    SciTech Connect

    Robinson, L.J.; Michel, T.; Weremowicz, S.; Morton, C.C. )

    1994-01-15

    Endothelial NOS activity is a major determinant of vascular tone and blood pressure, and in several important (and sometimes hereditary) disease states, such as hypertension, diabetes, and atherosclerosis, the endothelial NO signaling system appears to be abnormal. To explore the relationship of the endothelial NOS activity, the authors isolated the human gene encoding the endothelial NOS. Genomic clones containing the 5[prime] end of this gene were identified in a human genomic library by applying a polymerase chain reaction (PCR)-based approach. Identification of the human gene for endothelial NOS (NOS3) was confirmed by nucleotide sequence analysis of the first coding exon, which was found to be identical to its cognate cDNA. The NOS3 gene spans at least 20 kb and appears to contain multiple introns. The transcription start site and promoter region of the NOS3 gene were identified by primer extension and ribonuclease protection assays. Sequencing of the putative promoter revealed consensus sequences for the shear stress-response element, as well as cytokine-responsive cis regulatory sequences, both possible important to the roles played by NOS3 in the normal and the diseased cardiovascular system. The authors also mapped the chromosomal location of the NOS3 gene. First, a chromosomal panel of human-rodent somatic cell hybrids was screened using PCR with oligonucleotide primers derived from the NOS3 genomic clone. The specificity of the amplified PCR product was confirmed by human and hamster genomic DNA controls, as well as by Southern blot analysis, using the NOS3 cDNA as probe. Definitive chromosomal assignment of the NOS3 gene to human chromosome 7 was based upon 0% discordancy; fluorescence in situ hybridization sublocalized the NOS3 gene to 7q36. The identification and characterization of the NOS3 gene may lead to further insights into heritable disease states associated with this gene product. 41 refs., 3 figs., 1 tab.

  11. Using a Professional Development Program for Enhancing Chilean Biology Teachers' Understanding of Nature of Science (NOS) and Their Perceptions about Using History of Science to Teach NOS

    ERIC Educational Resources Information Center

    Pavez, José M.; Vergara, Claudia A.; Santibañez, David; Cofré, Hernán

    2016-01-01

    A number of authors have recognized the importance of understanding the nature of science (NOS) for scientific literacy. Different instructional strategies such as decontextualized, hands-on inquiry, and history of science (HOS) activities have been proposed for teaching NOS. This article seeks to understand the contribution of HOS in enhancing…

  12. 102. Interior view of utilidor passageway link between building nos. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    102. Interior view of utilidor passageway link between building nos. 101 and 102 showing waveguides on left and cable tray system on right sides. Note fire suppression water supply piping (upper center). Small maintenance 3-wheel vehicle at center (Note: similar vehicles still in use in 2001.) Official photograph BMEWS Project by Hansen, Photographic Services, Riverton, NJ, BMEWS, clear as negative no. A-101123. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  13. 12. "TEST STANDS NOS. 11, 13, & 15; CONCRETE STRUCTURAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. "TEST STANDS NOS. 1-1, 1-3, & 1-5; CONCRETE STRUCTURAL SECTIONS AND DETAILS." Specifications No. OC12-50-10; Drawing No. 60-09-06; no sheet number within title block. D.O. SERIES 1109/16, Rev. E. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract DA-04353 Eng. 177, Rev. E; Date: 26 Dec. 1951. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-5, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

  14. 14. "TEST STANDS NOS. 11, 13, & 15; MISCELLANEOUS DETAILS." ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. "TEST STANDS NOS. 1-1, 1-3, & 1-5; MISCELLANEOUS DETAILS." Specifications No. OC12-50-10; Drawing No. 60-09-04; no sheet number within title block. D.O. SERIES 1109/22, Rev. D. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract DA-04-353 Eng. 177, Rev. D, no change; Date: 17 Dec. 1951. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-5, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

  15. 13. "TEST STANDS NOS. 11, 13, & 15; CONCRETE STRUCTURAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. "TEST STANDS NOS. 1-1, 1-3, & 1-5; CONCRETE STRUCTURAL SECTIONS AND DETAILS." Specifications No. OC12-50-10; Drawing No. 60-09-04; no sheet number within title block. D.O. SERIES 1109/18, Rev. D. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract DA-04353 Eng. 177, Rev. D, no change; Date: 18 Dec. 1951. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-5, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

  16. 10. "TEST STANDS NOS. 11, 13, & 15; CONCRETE STRUCTURAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. "TEST STANDS NOS. 1-1, 1-3, & 1-5; CONCRETE STRUCTURAL SECTIONS AND DETAILS." Specifications No. OC12-50-10; Drawing No. 60-09-04; no sheet number within title block. D.O. SERIES 1109/14, Rev. B. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract DA-04353 Eng. 177, Rev. B; Date: 21 Dec. 1951. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-5, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

  17. 11. "TEST STANDS NOS. 11, 13, & 15; CONCRETE STRUCTURAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. "TEST STANDS NOS. 1-1, 1-3, & 1-5; CONCRETE STRUCTURAL SECTIONS AND DETAILS." Specifications No. OC12-50-10; Drawing No. 60-09-04; no sheet number within title block. D.O. SERIES 1109/15, Rev. E. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract DA-04353 Eng. 177, Rev. E; Date: 21 Dec. 1951. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-5, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

  18. 9. "TEST STANDS NOS. 11, 13, & 15; CONCRETE STRUCTURAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. "TEST STANDS NOS. 1-1, 1-3, & 1-5; CONCRETE STRUCTURAL SECTIONS AND DETAILS." Specifications No. ENG 04-35350-10; Drawing No. 60-09-04; no sheet number within title block. D.O. SERIES 1109/13. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract DA-04353 Eng. 177, no change; Date: 17 Dec. 1951. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-5, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

  19. 16. "TEST STANDS NOS. 11, 13, & 15; STRUCTURAL STEEL; ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. "TEST STANDS NOS. 1-1, 1-3, & 1-5; STRUCTURAL STEEL; ELEVATIONS AND SECTIONS." Specifications No. ENG 04353-50-10; Drawing No. 60-09-04; no sheet number within title block. D.O. SERIES 1109/35, Rev. A. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract DA-04-353 Eng. 177, Rev. A; Date: 29 Dec. 1951. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-5, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

  20. 15. "TEST STANDS NOS. 11, 13, & 15; STRUCTURAL STEEL; ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. "TEST STANDS NOS. 1-1, 1-3, & 1-5; STRUCTURAL STEEL; PLAN & DETAILS." Specifications No. ENG 04-353-50-10; Drawing No. 60-09-04; no sheet number within title block. D.O. SERIES 1109/34, Rev. A. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract DA-04353 Eng. 177, Rev. A, no change; Date: 21 Dec. 1951. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-5, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

  1. The KEA image file format

    NASA Astrophysics Data System (ADS)

    Bunting, Peter; Gillingham, Sam

    2013-08-01

    There are a large number of image formats already in use within the remote sensing community but currently there is no format that provides the features of: compression, support for large file sizes, ground control points, raster attribute tables and inbuilt image pyramids. Therefore, a new image format, named KEA, after the New Zealand bird, has been proposed. The KEA format provides a full implementation of the GDAL data model and is implemented within a HDF5 file. A software library with a GDAL driver have been freely provided to the community allowing use through any GDAL based software. The new format has comparable performance with existing formats while producing smaller file sizes and is already within active use for a number of projects within Landcare Research, New Zealand, and the wider community.

  2. Adaptive Runge-Kutta integration for stiff systems: Comparing Nosé and Nosé-Hoover dynamics for the harmonic oscillator

    NASA Astrophysics Data System (ADS)

    Graham Hoover, William; Clinton Sprott, Julien; Griswold Hoover, Carol

    2016-10-01

    We describe the application of adaptive (variable time step) integrators to stiff differential equations encountered in many applications. Linear harmonic oscillators subject to nonlinear thermal constraints can exhibit either stiff or smooth dynamics. Two closely related examples, Nosé's dynamics and Nosé-Hoover dynamics, are both based on Hamiltonian mechanics and generate microstates consistent with Gibbs' canonical ensemble. Nosé's dynamics is stiff and can present severe numerical difficulties. Nosé-Hoover dynamics, although it follows exactly the same trajectory, is smooth and relatively trouble-free. We emphasize the power of adaptive integrators to resolve stiff problems such as the Nosé dynamics for the harmonic oscillator. The solutions also illustrate the power of computer graphics to enrich numerical solutions.

  3. 76 FR 68437 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-04

    .... Description: National Fuel Gas Supply Corporation submits tariff filing per 154.204: IG Rate for November 2011..., but intervention is necessary to become a party to the proceeding. Filings in Existing...

  4. 77 FR 67355 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-09

    ... intervene or protest in any of the above proceedings must file in accordance with Rules 211 and 214 of the... person desiring to protest in any the above proceedings must file in accordance with Rule 211 of...

  5. 78 FR 25071 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-29

    ....m. ET 5/1/13. Any person desiring to intervene or protest in any of the above proceedings must file... desiring to protest in any the above proceedings must file in accordance with Rule 211 of the...

  6. 78 FR 49494 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-14

    ..., LLC. Description: Big Sandy Fuel Filing effective 9-1-2013. Filed Date: 7/31/13. Accession Number... Gas Transmission, L. Description: Neg Rate 2013-07-31 Green Plains fka Choice Ethanol to be...

  7. Fail-over file transfer process

    NASA Technical Reports Server (NTRS)

    Semancik, Susan K. (Inventor); Conger, Annette M. (Inventor)

    2005-01-01

    The present invention provides a fail-over file transfer process to handle data file transfer when the transfer is unsuccessful in order to avoid unnecessary network congestion and enhance reliability in an automated data file transfer system. If a file cannot be delivered after attempting to send the file to a receiver up to a preset number of times, and the receiver has indicated the availability of other backup receiving locations, then the file delivery is automatically attempted to one of the backup receiving locations up to the preset number of times. Failure of the file transfer to one of the backup receiving locations results in a failure notification being sent to the receiver, and the receiver may retrieve the file from the location indicated in the failure notification when ready.

  8. 47 CFR 1.1704 - Station files.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Cable Operations and Licensing System (COALS) § 1.1704 Station files. Applications, notifications, correspondence, electronic filings... relating to each system in the Multichannel Video and Cable Television Services (MVCTS) and the...

  9. 75 FR 67356 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-02

    .... Docket Numbers: RP11-1420-000. Applicants: ETC Tiger Pipeline, LLC. Description: ETC Tiger Pipeline, LLC submits tariff filing per 154.203: Tiger NAESB Version 1.9 Compliance Filing to be effective 12/...

  10. 75 FR 66749 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-29

    .... Docket Numbers: RP11-1420-000. Applicants: ETC Tiger Pipeline, LLC. Description: ETC Tiger Pipeline, LLC submits tariff filing per 154.203: Tiger NAESB Version 1.9 Compliance Filing to be effective 12/...

  11. 78 FR 58533 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-24

    ... received the following Natural Gas Pipeline Rate and Refund Report filings: Filings Instituting Proceedings... Docket Numbers: CP13-548-000 Applicants: Montana-Dakota Utilities Co. Description: Application for...

  12. 12 CFR 303.221 - Filing procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... PROCEDURES Section 19 of the FDI Act (Consent to Service of Persons Convicted of Certain Criminal Offenses) § 303.221 Filing procedures. (a) Where to file. An application under section 19 of the FDI Act shall...

  13. 77 FR 506 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

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    ... Express, LLC. Filing Party: Wade S. Hooker, Esq.; 211 Central Park W; New York, NY 10024. Synopsis: The... Interoceanica, S.A and Hamburg Sudamerikanische Dampfschiffahrts-Gesellschaft KG. Filing Party: Wade S....

  14. 78 FR 76624 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

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    ... & Logistic GmbH & Co. KG; Industrial Maritime Carriers LLC; Seaboard Marine, Ltd. Filing Party: Wade S...H & Cie. KG. Filing Party: Wade S. Hooker, Esq.; 211 Central Park W; New York, NY 10024....

  15. 77 FR 60433 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

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    ... Express, Inc. and Great White Fleet Liner Services Ltd. Filing Party: Wade S. Hooker, Esq., 211 Central... White Fleet Liner Services Ltd. and Crowley Latin American Services, LLC. Filing Party: Wade S....

  16. 77 FR 13604 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-07

    ...-Linie GmbH & Cie. KG. Filing Party: Wade S. Hooker, Esquire; 211 Central Park W.; New York, NY 10024.... Parties: Great White Fleet (US) Ltd. and Agriculture Investment Export, Inc. Filing Party: Wade S....

  17. File-based data processing on MESSENGER

    NASA Astrophysics Data System (ADS)

    Krupiarz, Christopher J.; Artis, David A.; Calloway, Andrew B.; Frangos, Constantine M.; Heggestad, Brian K.; Holland, Douglas B.; Stratton, William C.

    2006-10-01

    As part of the system software, MESSENGER will be using a file-based system for the transfer and processing of instrument and spacecraft data. The flow of files within the MESSENGER software architecture begins with the receipt of science data by the main processor and the creation of files containing these data by the flight software. The files are then autonomously selected for downlink via a priority-based algorithm, packaged for transmittal via the CCSDS File Delivery Protocol (CFDP), and radiated to the ground. The ground software reconstructs the files via its implementation of CFDP, performs further processing on the file, and sends it to the operations data archive and the Science Operations Center. The MESSENGER spacecraft operations team manages the overall handling of these files through interaction with both the flight and ground systems.

  18. File-based data processing on MESSENGER

    NASA Astrophysics Data System (ADS)

    Krupiarz, Christopher J.; Artis, David A.; Calloway, Andrew B.; Frangos, Constantine M.; Heggestad, Brian K.; Holland, Douglas B.; Stratton, William C.

    2003-11-01

    As part of the system software, MESSENGER will be using a file-based system for the transfer and processing of instrument and spacecraft data. The flow of files within the MESSENGER software architecture begins with the receipt of science data by the main processor and the creation of files containing these data by the flight software. The files are then autonomously selected for downlink via a priority-based algorithm, packaged for transmittal via the CCSDS File Delivery Protocol (CFDP), and radiated to the ground. The ground software reconstructs the files via its implementation of CFDP, performs further processing on the file, and sends it to the operations data archive and the Science Operations Center. The MESSENGER spacecraft operations team manages the overall handling of these files through interaction with both the flight and ground systems.

  19. 78 FR 46935 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-02

    ...: 20130725-5032. Comments Due: 5 p.m. ET 8/6/13. Docket Numbers: RP13-1098-000. Applicants: Bison Pipeline LLC. Description: Bison Pipeline LLC submits tariff filing per 154.203: ACA Filing 2013 to...

  20. 77 FR 56197 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-12

    ... Pipeline Company, LLC. Description: Hurricane Surcharge Filing on 8-31-12 to be effective 10/1/2012. Filed...: RP12-999-000. Applicants: Big Sandy Pipeline, LLC. Description: NegRate Pass-through Process to...