Towards automated assistance for operating home medical devices.

PubMed

Gao, Zan; Detyniecki, Marcin; Chen, Ming-Yu; Wu, Wen; Hauptmann, Alexander G; Wactlar, Howard D

2010-01-01

To detect errors when subjects operate a home medical device, we observe them with multiple cameras. We then perform action recognition with a robust approach to recognize action information based on explicitly encoding motion information. This algorithm detects interest points and encodes not only their local appearance but also explicitly models local motion. Our goal is to recognize individual human actions in the operations of a home medical device to see if the patient has correctly performed the required actions in the prescribed sequence. Using a specific infusion pump as a test case, requiring 22 operation steps from 6 action classes, our best classifier selects high likelihood action estimates from 4 available cameras, to obtain an average class recognition rate of 69%.

75 FR 26906 - Connect America Fund, A National Broadband Plan for Our Future, High-Cost Universal Service Support

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-13

... recommending that the Commission adopt cost-cutting measures for existing voice support and create a Connect... specific common-sense reforms to cap growth and cut inefficient funding in the legacy high-cost support... other regulatory actions? 2. Specific Steps To Cut Legacy High-Cost Support 3. As discussed in more...

Molecular mechanism of ERK dephosphorylation by striatal-enriched protein tyrosine phosphatase (STEP)

PubMed Central

Li, Hui; Li, Kang-shuai; Su, Jing; Chen, Lai-Zhong; Xu, Yun-Fei; Wang, Hong-Mei; Gong, Zheng; Cui, Guo-Ying; Yu, Xiao; Wang, Kai; Yao, Wei; Xin, Tao; Li, Min-Yong; Xiao, Kun-Hong; An, Xiao-fei; Huo, Yuqing; Xu, Zhi-gang; Sun, Jin-Peng; Pang, Qi

2013-01-01

Striatal-enriched tyrosine phosphatase (STEP) is an important regulator of neuronal synaptic plasticity, and its abnormal level or activity contributes to cognitive disorders. One crucial downstream effector and direct substrate of STEP is extracellular signal-regulated protein kinase (ERK), which has important functions in spine stabilisation and action potential transmission. The inhibition of STEP activity toward phospho-ERK has the potential to treat neuronal diseases, but the detailed mechanism underlying the dephosphorylation of phospho-ERK by STEP is not known. Therefore, we examined STEP activity toward pNPP, phospho-tyrosine-containing peptides, and the full-length phospho-ERK protein using STEP mutants with different structural features. STEP was found to be a highly efficient ERK tyrosine phosphatase that required both its N-terminal regulatory region and key residues in its active site. Specifically, both KIM and KIS of STEP were required for ERK interaction. In addition to the N-terminal KIS region, S245, hydrophobic residues L249/L251, and basic residues R242/R243 located in the KIM region were important in controlling STEP activity toward phospho-ERK. Further kinetic experiments revealed subtle structural differences between STEP and HePTP that affected the interactions of their KIMs with ERK. Moreover, STEP recognised specific positions of a phospho-ERK peptide sequence through its active site, and the contact of STEP F311 with phospho-ERK V205 and T207 were crucial interactions. Taken together, our results not only provide the information for interactions between ERK and STEP, but will also help in the development of specific strategies to target STEP-ERK recognition, which could serve as a potential therapy for neurological disorders. PMID:24117863

Demonstrating and Evaluating an Action Learning Approach to Building Project Management Competence

NASA Technical Reports Server (NTRS)

Kotnour, Tim; Starr, Stan; Steinrock, T. (Technical Monitor)

2001-01-01

This paper contributes a description of an action-learning approach to building project management competence. This approach was designed, implemented, and evaluated for use with the Dynacs Engineering Development Contract at the Kennedy Space Center. The aim of the approach was to improve three levels of competence within the organization: individual project management skills, project team performance. and organizational capabilities such as the project management process and tools. The overall steps to the approach, evaluation results, and lessons learned are presented. Managers can use this paper to design a specific action-learning approach for their organization.

Boric acid reversibly inhibits the second step of pre-mRNA splicing.

PubMed

Shomron, Noam; Ast, Gil

2003-09-25

Several approaches have been used to identify the factors involved in mRNA splicing. None of them, however, comprises a straightforward reversible method for inhibiting the second step of splicing using an external reagent other than a chelator. This investigation demonstrates that the addition of boric acid to an in vitro pre-mRNA splicing reaction causes a dose-dependent reversible inhibition effect on the second step of splicing. The mechanism of action does not involve chelation of several metal ions; hindrance of 3' splice-site; or binding to hSlu7. This study presents a novel method for specific reversible inhibition of the second step of pre-mRNA splicing.

14 CFR 152.411 - Affirmative action steps.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Affirmative action steps. 152.411 Section...) AIRPORTS AIRPORT AID PROGRAM Nondiscrimination in Airport Aid Program § 152.411 Affirmative action steps. (a) Each grantee which is not described in § 152.407(a) and is not subject to an affirmative action...

A New Performance Improvement Model: Adding Benchmarking to the Analysis of Performance Indicator Data.

PubMed

Al-Kuwaiti, Ahmed; Homa, Karen; Maruthamuthu, Thennarasu

2016-01-01

A performance improvement model was developed that focuses on the analysis and interpretation of performance indicator (PI) data using statistical process control and benchmarking. PIs are suitable for comparison with benchmarks only if the data fall within the statistically accepted limit-that is, show only random variation. Specifically, if there is no significant special-cause variation over a period of time, then the data are ready to be benchmarked. The proposed Define, Measure, Control, Internal Threshold, and Benchmark model is adapted from the Define, Measure, Analyze, Improve, Control (DMAIC) model. The model consists of the following five steps: Step 1. Define the process; Step 2. Monitor and measure the variation over the period of time; Step 3. Check the variation of the process; if stable (no significant variation), go to Step 4; otherwise, control variation with the help of an action plan; Step 4. Develop an internal threshold and compare the process with it; Step 5.1. Compare the process with an internal benchmark; and Step 5.2. Compare the process with an external benchmark. The steps are illustrated through the use of health care-associated infection (HAI) data collected for 2013 and 2014 from the Infection Control Unit, King Fahd Hospital, University of Dammam, Saudi Arabia. Monitoring variation is an important strategy in understanding and learning about a process. In the example, HAI was monitored for variation in 2013, and the need to have a more predictable process prompted the need to control variation by an action plan. The action plan was successful, as noted by the shift in the 2014 data, compared to the historical average, and, in addition, the variation was reduced. The model is subject to limitations: For example, it cannot be used without benchmarks, which need to be calculated the same way with similar patient populations, and it focuses only on the "Analyze" part of the DMAIC model.

The memory is in the details: relations between memory for the specific features of events and long-term recall during infancy.

PubMed

Bauer, Patricia J; Lukowski, Angela F

2010-09-01

The second year of life is marked by pronounced changes in the length of time over which events are remembered. We tested whether the age-related differences are related to differences in memory for the specific features of events. In our study, 16- and 20-month-olds were tested for immediate and long-term recall of individual actions and temporal order of actions of three-step sequences in an elicited imitation paradigm as well as for forced-choice recognition of the specific feature of the props used to produce the sequences. Memory for the props was related to long-term recall of the events only for the 20-month-olds. It accounted for unique variance above and beyond the variance explained by immediate recall of the individual actions and the temporal order of actions of the sequences. The different pattern of relations in the older and younger infants seemingly reflects a developmental difference in the determinants of long-term recall over the second year of life. Copyright 2010 Elsevier Inc. All rights reserved.

Kinematic constraints associated with the acquisition of overarm throwing part I: step and trunk actions.

PubMed

Stodden, David F; Langendorfer, Stephen J; Fleisig, Glenn S; Andrews, James R

2006-12-01

The purposes of this study were to: (a) examine differences within specific kinematic variables and ball velocity associated with developmental component levels of step and trunk action (Roberton & Halverson, 1984), and (b) if the differences in kinematic variables were significantly associated with the differences in component levels, determine potential kinematic constraints associated with skilled throwing acquisition. Results indicated stride length (69.3 %) and time from stride foot contact to ball release (39. 7%) provided substantial contributions to ball velocity (p < .001). All trunk kinematic measures increased significantly with increasing component levels (p < .001). Results suggest that trunk linear and rotational velocities, degree of trunk tilt, time from stride foot contact to ball release, and ball velocity represented potential control parameters and, therefore, constraints on overarm throwing acquisition.

Prohibiting the President from deploying or maintaining United States Armed Forces in a sustained combat role in Iraq without specific, subsequent statutory authorization.

THOMAS, 113th Congress

Rep. McGovern, James P. [D-MA-2

2014-07-11

Senate - 07/28/2014 Received in the Senate and referred to the Committee on Foreign Relations. (All Actions) Tracker: This bill has the status Agreed to in HouseHere are the steps for Status of Legislation:

SUMMARY REPORT OF THE MEETING ON DEVELOPMENT OF A METALS ASSESSMENT FRAMEWORK

EPA Science Inventory

Under the auspices of the Agency's Science Policy Council, the Agency is embarking on the development of an assessment framework for metals. The first step in the process is formulation of an Action Plan that will identify key scientific issues specific to metals and metal compou...

Evolution of Bacillus thuringiensis Cry toxins insecticidal activity.

PubMed

Bravo, Alejandra; Gómez, Isabel; Porta, Helena; García-Gómez, Blanca Ines; Rodriguez-Almazan, Claudia; Pardo, Liliana; Soberón, Mario

2013-01-01

Insecticidal Cry proteins produced by Bacillus thuringiensis are use worldwide in transgenic crops for efficient pest control. Among the family of Cry toxins, the three domain Cry family is the better characterized regarding their natural evolution leading to a large number of Cry proteins with similar structure, mode of action but different insect specificity. Also, this group is the better characterized regarding the study of their mode of action and the molecular basis of insect specificity. In this review we discuss how Cry toxins have evolved insect specificity in nature and analyse several cases of improvement of Cry toxin action by genetic engineering, some of these examples are currently used in transgenic crops. We believe that the success in the improvement of insecticidal activity by genetic evolution of Cry toxins will depend on the knowledge of the rate-limiting steps of Cry toxicity in different insect pests, the mapping of the specificity binding regions in the Cry toxins, as well as the improvement of mutagenesis strategies and selection procedures. © 2012 The Authors. Microbial Biotechnology © 2012 Society for Applied Microbiology and Blackwell Publishing Ltd.

Using Action Planning to Build Organizational Capacity for the Prevention of Intimate Partner Violence.

PubMed

Schober, Daniel J; Fawcett, Stephen B

2015-08-01

The DELTA PREP Project aims to reduce risk for intimate partner violence (IPV). It engaged leadership and staff from 19 statewide domestic violence coalitions in building capacity to prevent IPV before it occurs (rather than solely responding to IPV). This article describes the process and outcomes associated with action planning to create coalition organizational change related to preventing IPV. Coalition staff and leadership planned for organizational changes in six goal areas: leadership, structures and processes, staffing, resource development, partnership development, and member agency development. Action planning was conducted during 2-day, in-person sessions that involved (a) review and refinement of coalition vision and mission statements, (b) interpretation of coalition assessments (for prevention capacity), (c) identification of specific organizational changes to be sought, and (d) specification of action steps for each proposed organizational change to be sought. The results show overall increases in the amounts, and variations in the kinds, of organizational changes that were facilitated by coalitions. Challenges related to action planning and future directions for capacity building among statewide IPV prevention coalitions are discussed. © 2015 Society for Public Health Education.

Kinetics of Neuraminidase Action on Glycoproteins by One- and Two-Dimensional NMR

ERIC Educational Resources Information Center

Barb, Adam W.; Glushka, John N.; Prestegard, James H.

2011-01-01

The surfaces of mammalian cells are coated with complex carbohydrates, many terminated with a negatively charged "N"-acetylneuraminic acid residue. This motif is specifically targeted by pathogens, including influenza viruses and many pathogenic bacteria, to gain entry into the cell. A necessary step in the influenza virus life cycle is the…

Specificity determinants for Cry insecticidal proteins: Insights from their mode of action.

PubMed

Jurat-Fuentes, Juan Luis; Crickmore, Neil

2017-01-01

Insecticidal proteins from the bacterium Bacillus thuringiensis (Bt) are used as active components of biopesticides and as plant incorporated protectants in transgenic crops. One of the most relevant attributes of these Bt protein-based insecticidal technologies is their high specificity, which assures lack of detrimental effects on non-target insects, vertebrates and the environment. The identification of specificity determinants in Bt insecticidal proteins could guide risk assessment for novel insecticidal proteins currently considered for commercialization. In this work we review the available data on specificity determinants of crystal (Cry) insecticidal proteins as the Bt toxins most well characterized and used in transgenic crops. The multi-step mode of action of the Cry insecticidal proteins allows various factors to potentially affect specificity determination and here we define seven levels that could influence specificity. The relative relevance of each of these determinants on efficacy of transgenic crops producing Cry insecticidal proteins is also discussed. Copyright © 2016 Elsevier Inc. All rights reserved.

Emotional influences on locomotor behavior.

PubMed

Naugle, Kelly M; Joyner, Jessica; Hass, Chris J; Janelle, Christopher M

2010-12-01

Emotional responses to appetitive and aversive stimuli motivate approach and avoidance behaviors essential for survival. The purpose of the current study was to determine the impact of specific emotional stimuli on forward, approach-oriented locomotion. Steady state walking was assessed while participants walked toward pictures varying in emotional content (erotic, happy people, attack, mutilation, contamination, and neutral). Step length and step velocity were calculated for the first two steps following picture onset. Exposure to the mutilation and contamination pictures shortened the lengths of step one and step two compared to the erotic pictures. Additionally, step velocity was greater during exposure to the erotic pictures compared to (1) the contamination and mutilation pictures for step one and (2) all other picture categories for step two. These findings suggest that locomotion is facilitated when walking toward approach-oriented emotional stimuli but compromised when walking toward aversive emotional stimuli. The data extend our understanding of fundamental interactions among motivational orientations, emotional reactions, and resultant actions. Theoretical and practical implications are discussed. Copyright © 2010 Elsevier Ltd. All rights reserved.

From framework to action: the DESIRE approach to combat desertification.

PubMed

Hessel, R; Reed, M S; Geeson, N; Ritsema, C J; van Lynden, G; Karavitis, C A; Schwilch, G; Jetten, V; Burger, P; van der Werff Ten Bosch, M J; Verzandvoort, S; van den Elsen, E; Witsenburg, K

2014-11-01

It has become increasingly clear that desertification can only be tackled through a multi-disciplinary approach that not only involves scientists but also stakeholders. In the DESIRE project such an approach was taken. As a first step, a conceptual framework was developed in which the factors and processes that may lead to land degradation and desertification were described. Many of these factors do not work independently, but can reinforce or weaken one another, and to illustrate these relationships sustainable management and policy feedback loops were included. This conceptual framework can be applied globally, but can also be made site-specific to take into account that each study site has a unique combination of bio-physical, socio-economic and political conditions. Once the conceptual framework was defined, a methodological framework was developed in which the methodological steps taken in the DESIRE approach were listed and their logic and sequence were explained. The last step was to develop a concrete working plan to put the project into action, involving stakeholders throughout the process. This series of steps, in full or in part, offers explicit guidance for other organizations or projects that aim to reduce land degradation and desertification.

Are patients comprehending? A critical assessment of online patient educational materials.

PubMed

Bui, Thanh-Lan; Silva-Hirschberg, Catalina; Torres, Josefina; Armstrong, April W

2018-05-01

The primary aim of this study was to evaluate the readability, understandability, suitability and actionability of online psoriasis patient educational materials. A secondary aim was to identify areas for improvement. We conducted an evaluation study to assess online psoriasis patient educational materials from the American Academy of Dermatology and National Psoriasis Foundation available in July 2017. We used two validated assessment tools specific to online healthcare materials. Outcomes were expressed as percentages, where higher percentages corresponded to higher quality materials. Overall, the educational materials had a mean understandability score (72.7%) that was understandable; a suitability score (58.8%) that was adequate; a reading grade level (10.5) that was not readable; and an actionability score (54.7%) that was not actionable. Areas of improvement include reading grade level, visual aids, word choice, specific steps for actions and cultural appropriateness. Online psoriasis patient educational materials are understandable and suitable, but they are written above the American Medical Association and National Institutes of Health's recommended 6th-8th grade reading level and are not actionable. Materials can benefit from decreasing reading grade level, including more visual elements, incorporating more actionable items and being culturally inclusive.

Specific issues, exact locations: case study of a community mapping project to improve safety in a disadvantaged community.

PubMed

Qummouh, Rana; Rose, Vanessa; Hall, Pat

2012-12-01

Safety is a health issue and a significant concern in disadvantaged communities. This paper describes an example of community-initiated action to address perceptions of fear and safety in a suburb in south-west Sydney which led to the development of a local, community-driven research project. As a first step in developing community capacity to take action on issues of safety, a joint resident-agency group implemented a community safety mapping project to identify the extent of safety issues in the community and their exact geographical location. Two aerial maps of the suburb, measuring one metre by two metres, were placed on display at different locations for four months. Residents used coloured stickers to identify specific issues and exact locations where crime and safety were a concern. Residents identified 294 specific safety issues in the suburb, 41.9% (n=123) associated with public infrastructure, such as poor lighting and pathways, and 31.9% (n=94) associated with drug-related issues such as drug activity and discarded syringes. Good health promotion practice reflects community need. In a very practical sense, this project responded to community calls for action by mapping resident knowledge on specific safety issues and exact locations and presenting these maps to local decision makers for further action.

Federal supports for state oral health plans.

PubMed

Edelstein, Burton L

2012-01-01

The past decade has witnessed both a proliferation of state oral health plans that include very specific proposals for action and an emergence of federal laws that include support for oral health. This paper provides an overview of state oral health priorities for action as reflected in 40 oral health plans that were developed independently by states. It examines four federal laws - the 2002 Safety Net Improvement Act, the 2009 CHIP Reauthorization Act, the 2009 economic stimulus law, and the 2010 health reform law - to identify opportunities for alignment with action steps proposed in state plans. This analysis identifies 23 categories of activity proposed by states in their action plans and determines that all but six of these activities are now supported by one or more of these four federal laws. State activities undertaken through grants provided under the 2002 Safety Net Improvement Act are analyzed as an example of how states can leverage federal legislation to advance their oral health plans. The paper concludes with consideration of the steps needed for states to promote their oral health plans by leveraging the full capacity of federal legislation. © 2012 American Association of Public Health Dentistry.

Modeling metabolic networks in C. glutamicum: a comparison of rate laws in combination with various parameter optimization strategies

PubMed Central

Dräger, Andreas; Kronfeld, Marcel; Ziller, Michael J; Supper, Jochen; Planatscher, Hannes; Magnus, Jørgen B; Oldiges, Marco; Kohlbacher, Oliver; Zell, Andreas

2009-01-01

Background To understand the dynamic behavior of cellular systems, mathematical modeling is often necessary and comprises three steps: (1) experimental measurement of participating molecules, (2) assignment of rate laws to each reaction, and (3) parameter calibration with respect to the measurements. In each of these steps the modeler is confronted with a plethora of alternative approaches, e. g., the selection of approximative rate laws in step two as specific equations are often unknown, or the choice of an estimation procedure with its specific settings in step three. This overall process with its numerous choices and the mutual influence between them makes it hard to single out the best modeling approach for a given problem. Results We investigate the modeling process using multiple kinetic equations together with various parameter optimization methods for a well-characterized example network, the biosynthesis of valine and leucine in C. glutamicum. For this purpose, we derive seven dynamic models based on generalized mass action, Michaelis-Menten and convenience kinetics as well as the stochastic Langevin equation. In addition, we introduce two modeling approaches for feedback inhibition to the mass action kinetics. The parameters of each model are estimated using eight optimization strategies. To determine the most promising modeling approaches together with the best optimization algorithms, we carry out a two-step benchmark: (1) coarse-grained comparison of the algorithms on all models and (2) fine-grained tuning of the best optimization algorithms and models. To analyze the space of the best parameters found for each model, we apply clustering, variance, and correlation analysis. Conclusion A mixed model based on the convenience rate law and the Michaelis-Menten equation, in which all reactions are assumed to be reversible, is the most suitable deterministic modeling approach followed by a reversible generalized mass action kinetics model. A Langevin model is advisable to take stochastic effects into account. To estimate the model parameters, three algorithms are particularly useful: For first attempts the settings-free Tribes algorithm yields valuable results. Particle swarm optimization and differential evolution provide significantly better results with appropriate settings. PMID:19144170

Systems Maintenance Automated Repair Tasks (SMART)

NASA Technical Reports Server (NTRS)

Schuh, Joseph; Mitchell, Brent; Locklear, Louis; Belson, Martin A.; Al-Shihabi, Mary Jo Y.; King, Nadean; Norena, Elkin; Hardin, Derek

2010-01-01

SMART is a uniform automated discrepancy analysis and repair-authoring platform that improves technical accuracy and timely delivery of repair procedures for a given discrepancy (see figure a). SMART will minimize data errors, create uniform repair processes, and enhance the existing knowledge base of engineering repair processes. This innovation is the first tool developed that links the hardware specification requirements with the actual repair methods, sequences, and required equipment. SMART is flexibly designed to be useable by multiple engineering groups requiring decision analysis, and by any work authorization and disposition platform (see figure b). The organizational logic creates the link between specification requirements of the hardware, and specific procedures required to repair discrepancies. The first segment in the SMART process uses a decision analysis tree to define all the permutations between component/ subcomponent/discrepancy/repair on the hardware. The second segment uses a repair matrix to define what the steps and sequences are for any repair defined in the decision tree. This segment also allows for the selection of specific steps from multivariable steps. SMART will also be able to interface with outside databases and to store information from them to be inserted into the repair-procedure document. Some of the steps will be identified as optional, and would only be used based on the location and the current configuration of the hardware. The output from this analysis would be sent to a work authoring system in the form of a predefined sequence of steps containing required actions, tools, parts, materials, certifications, and specific requirements controlling quality, functional requirements, and limitations.

White Innocence and Mexican Americans as Perpetrators in the School-to-Prison Pipeline

ERIC Educational Resources Information Center

Orozco, Richard

2013-01-01

This essay discusses white innocence as a mechanism that may contribute to perceptions of Mexican Americans as perpetrators. These perceptions are crucial to ways teachers and administrators respond to student actions as the initial steps in the school-to-prison pipeline. Specifically, this work reviews the rhetoric of white innocence in a high…

Problematising the Use of Education to Address Social Inequity: Could Participatory Action Research Be a Step Forwards?

ERIC Educational Resources Information Center

Giannakaki, Marina-Stefania; McMillan, Ian David; Karamichas, John

2018-01-01

This paper critiques international trends towards certain school practices aimed at promoting equity and social justice by closing gaps in specific learning outcomes among students. It argues that even though some of these practices (e.g. individualised student support, data-driven leadership) improve learning outcomes for certain groups…

Proposing an amendment to the Constitution of the United States allowing the States to call a limited convention solely for the purposes of considering whether to propose a specific amendment to the Constitution.

THOMAS, 111th Congress

Rep. Minnick, Walter [D-ID-1

2010-07-30

House - 09/20/2010 Referred to the Subcommittee on the Constitution, Civil Rights, and Civil Liberties. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Exploring the Relationships Between USMLE Performance and Disciplinary Action in Practice: A Validity Study of Score Inferences From a Licensure Examination.

PubMed

Cuddy, Monica M; Young, Aaron; Gelman, Andrew; Swanson, David B; Johnson, David A; Dillon, Gerard F; Clauser, Brian E

2017-12-01

Physicians must pass the United States Medical Licensing Examination (USMLE) to obtain an unrestricted license to practice allopathic medicine in the United States. Little is known, however, about how well USMLE performance relates to physician behavior in practice, particularly conduct inconsistent with safe, effective patient care. The authors examined the extent to which USMLE scores relate to the odds of receiving a disciplinary action from a U.S. state medical board. Controlling for multiple factors, the authors used non-nested multilevel logistic regression analyses to estimate the relationships between scores and receiving an action. The sample included 164,725 physicians who graduated from U.S. MD-granting medical schools between 1994 and 2006. Physicians had a mean Step 1 score of 214 (standard deviation [SD] = 21) and a mean Step 2 Clinical Knowledge (CK) score of 213 (SD = 23). Of the physicians, 2,205 (1.3%) received at least one action. Physicians with higher Step 2 CK scores had lower odds of receiving an action. A 1-SD increase in Step 2 CK scores corresponded to a decrease in the chance of disciplinary action by roughly 25% (odds ratio = 0.75; 95% CI = 0.70-0.80). After accounting for Step 2 CK scores, Step 1 scores were unrelated to the odds of receiving an action. USMLE Step 2 CK scores provide useful information about the odds a physician will receive an official sanction for problematic practice behavior. These results provide validity evidence supporting current interpretation and use of Step 2 CK scores.

"Cast Your Net Widely": Three Steps to Expanding and Refining Your Problem before Action Learning Application

ERIC Educational Resources Information Center

Reese, Simon R.

2015-01-01

This paper reflects upon a three-step process to expand the problem definition in the early stages of an action learning project. The process created a community-powered problem-solving approach within the action learning context. The simple three steps expanded upon in the paper create independence, dependence, and inter-dependence to aid the…

Quadratic adaptive algorithm for solving cardiac action potential models.

PubMed

Chen, Min-Hung; Chen, Po-Yuan; Luo, Ching-Hsing

2016-10-01

An adaptive integration method is proposed for computing cardiac action potential models accurately and efficiently. Time steps are adaptively chosen by solving a quadratic formula involving the first and second derivatives of the membrane action potential. To improve the numerical accuracy, we devise an extremum-locator (el) function to predict the local extremum when approaching the peak amplitude of the action potential. In addition, the time step restriction (tsr) technique is designed to limit the increase in time steps, and thus prevent the membrane potential from changing abruptly. The performance of the proposed method is tested using the Luo-Rudy phase 1 (LR1), dynamic (LR2), and human O'Hara-Rudy dynamic (ORd) ventricular action potential models, and the Courtemanche atrial model incorporating a Markov sodium channel model. Numerical experiments demonstrate that the action potential generated using the proposed method is more accurate than that using the traditional Hybrid method, especially near the peak region. The traditional Hybrid method may choose large time steps near to the peak region, and sometimes causes the action potential to become distorted. In contrast, the proposed new method chooses very fine time steps in the peak region, but large time steps in the smooth region, and the profiles are smoother and closer to the reference solution. In the test on the stiff Markov ionic channel model, the Hybrid blows up if the allowable time step is set to be greater than 0.1ms. In contrast, our method can adjust the time step size automatically, and is stable. Overall, the proposed method is more accurate than and as efficient as the traditional Hybrid method, especially for the human ORd model. The proposed method shows improvement for action potentials with a non-smooth morphology, and it needs further investigation to determine whether the method is helpful during propagation of the action potential. Copyright © 2016 Elsevier Ltd. All rights reserved.

Organizing Community-Wide Dialogue for Action and Change: A Step-by-Step Guide.

ERIC Educational Resources Information Center

Campbell, Sarah vL.; Malick, Amy; Landesman, John; Barrett, Molly Holme; Leighninger, Matt; McCoy, Martha L.; Scully, Patrick L.

This document is a step-by-step guide to organizing a study circle program to serve as a vehicle to achieve communitywide dialogue for action and change. Part 1 provides an overview of communitywide study circle programs, with special emphasis on their operation and impact. Part 2 details the following steps in organizing a communitywide study…

Steps for arm and trunk actions of overhead forehand stroke used in badminton games across skill levels.

PubMed

Wang, Jianyu; Liu, Wenhao; Moffit, Jeffrey

2009-08-01

The purpose of this study was to examine arm and trunk actions in overhead forehand strokes used in badminton games across skill levels. The participants were 80 students (40 boys, 40 girls) who were randomly selected from video recordings of 300 students ages 16 to 19 years. The videotaped performances of overhead forehand strokes were coded based on three steps of arm action (elbow flexion, elbow and humeral flexion, and upward backswing) and three steps of trunk action (no trunk action, forward-backward movement, and trunk rotation). Students across the four skill levels exhibited different patterns of arm and trunk actions. Students at advanced levels used more mature arm and trunk actions.

Data on the configuration design of internet-connected home cooling systems by engineering students.

PubMed

McComb, Christopher; Cagan, Jonathan; Kotovsky, Kenneth

2017-10-01

This experiment was carried out to record the step-by-step actions that humans take in solving a configuration design problem, either in small teams or individually. Specifically, study participants were tasked with configuring an internet-connected system of products to maintain temperature within a home, subject to cost constraints. Every participant was given access to a computer-based design interface that allowed them to construct and assess solutions. The interface was also used to record the data that is presented here. In total, data was collected for 68 participants, and each participant was allowed to perform 50 design actions in solving the configuration design problem. Major results based on the data presented here have been reported separately, including initial behavioral analysis (McComb et al.) [1], [2] and design pattern assessments via Markovian modeling (McComb et al., 2017; McComb et al., 2017) [3], [4].

PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps.

PubMed

Kobayashi, Tatsuya; Chung, Ung-Il; Schipani, Ernestina; Starbuck, Michael; Karsenty, Gerard; Katagiri, Takenobu; Goad, Dale L; Lanske, Beate; Kronenberg, Henry M

2002-06-01

In developing murine growth plates, chondrocytes near the articular surface (periarticular chondrocytes) proliferate, differentiate into flat column-forming proliferating cells (columnar chondrocytes), stop dividing and finally differentiate into hypertrophic cells. Indian hedgehog (Ihh), which is predominantly expressed in prehypertrophic cells, stimulates expression of parathyroid hormone (PTH)-related peptide (PTHrP) which negatively regulates terminal chondrocyte differentiation through the PTH/PTHrP receptor (PPR). However, the roles of PTHrP and Ihh in regulating earlier steps in chondrocyte differentiation are unclear. We present novel mouse models with PPR abnormalities that help clarify these roles. In mice with chondrocyte-specific PPR ablation and mice with reduced PPR expression, chondrocyte differentiation was accelerated not only at the terminal step but also at an earlier step: periarticular to columnar differentiation. In these models, upregulation of Ihh action in the periarticular region was also observed. In the third model in which the PPR was disrupted in about 30% of columnar chondrocytes, Ihh action in the periarticular chondrocytes was upregulated because of ectopically differentiated hypertrophic chondrocytes that had lost PPR. Acceleration of periarticular to columnar differentiation was also noted in this mouse, while most of periarticular chondrocytes retained PPR signaling. These data suggest that Ihh positively controls differentiation of periarticular chondrocytes independently of PTHrP. Thus, chondrocyte differentiation is controlled at multiple steps by PTHrP and Ihh through the mutual regulation of their activities.

Reconstructing biochemical pathways from time course data.

PubMed

Srividhya, Jeyaraman; Crampin, Edmund J; McSharry, Patrick E; Schnell, Santiago

2007-03-01

Time series data on biochemical reactions reveal transient behavior, away from chemical equilibrium, and contain information on the dynamic interactions among reacting components. However, this information can be difficult to extract using conventional analysis techniques. We present a new method to infer biochemical pathway mechanisms from time course data using a global nonlinear modeling technique to identify the elementary reaction steps which constitute the pathway. The method involves the generation of a complete dictionary of polynomial basis functions based on the law of mass action. Using these basis functions, there are two approaches to model construction, namely the general to specific and the specific to general approach. We demonstrate that our new methodology reconstructs the chemical reaction steps and connectivity of the glycolytic pathway of Lactococcus lactis from time course experimental data.

QUICR-learning for Multi-Agent Coordination

NASA Technical Reports Server (NTRS)

Agogino, Adrian K.; Tumer, Kagan

2006-01-01

Coordinating multiple agents that need to perform a sequence of actions to maximize a system level reward requires solving two distinct credit assignment problems. First, credit must be assigned for an action taken at time step t that results in a reward at time step t > t. Second, credit must be assigned for the contribution of agent i to the overall system performance. The first credit assignment problem is typically addressed with temporal difference methods such as Q-learning. The second credit assignment problem is typically addressed by creating custom reward functions. To address both credit assignment problems simultaneously, we propose the "Q Updates with Immediate Counterfactual Rewards-learning" (QUICR-learning) designed to improve both the convergence properties and performance of Q-learning in large multi-agent problems. QUICR-learning is based on previous work on single-time-step counterfactual rewards described by the collectives framework. Results on a traffic congestion problem shows that QUICR-learning is significantly better than a Q-learner using collectives-based (single-time-step counterfactual) rewards. In addition QUICR-learning provides significant gains over conventional and local Q-learning. Additional results on a multi-agent grid-world problem show that the improvements due to QUICR-learning are not domain specific and can provide up to a ten fold increase in performance over existing methods.

National workshop on core competencies for success in the veterinary profession.

PubMed

Lloyd, James W; King, Lonnie J; Klausner, Jeffrey S; Harris, Donna

2003-01-01

A workshop was designed to (1) present results of the Core Competencies for Veterinary Medicine project conducted by Personnel Decisions International (PDI); (2) discuss and analyze the implications of the PDI study results for academia, private practice, and industry; (3) identify actionable items-discuss opportunities and barriers; and (4) develop appropriate recommendations-devise specific actions for implementation as next steps. In total, 25 veterinary colleges were represented at the workshop and a total of 110 attendees participated, a broad cross-section of the veterinary profession (both academic and non-academic). Through an orchestrated combination of general sessions and facilitated, small group discussions, prioritized recommendations for implementation and initial action plans for next steps were developed. Recommendations included publicizing results of the PDI study, reconsidering current admissions policies and processes, evaluating the applicant pool and current recruitment programs, developing structured mentoring programs, enhancing DVM/VMD training programs, coordinating the development of continuing education programs, and overcoming existing barriers to change. Next steps should involve collaborative efforts across all sectors of the veterinary profession to develop plans for implementing the workshop's recommendations. Leadership for follow-up might reasonably come from the Association of American Veterinary Medical Colleges (AAVMC), the American Veterinary Medical Association (AVMA), and the American Animal Hospital Association (AAHA), either individually or collectively, through the National Commission on Veterinary Economic Issues (NCVEI). Partnerships with industry are also possible and should be strongly considered.

Directing the Secretary of the Treasury to transmit to the House of Representatives all information in his possession relating to specific communications with American International Group, Inc. (AIG).

THOMAS, 111th Congress

Rep. LaTourette, Steven C. [R-OH-14

2009-03-17

House - 04/23/2009 Placed on the House Calendar, Calendar No. 45. (All Actions) Notes: On 5/7/2009, a motion was filed to discharge the Committee on Rules from consideration of H.Res.359 a resolution providing for consideration of H.Res.251. A discharge petition requires 218 signatures for further action. (Discharge Petition No. 111-3: text with signatures.) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Being a Positive Bystander: Male Antiviolence Allies’ Experiences of “Stepping Up”

PubMed Central

Casey, Erin A.; Ohler, Kristin

2014-01-01

As bystander approaches become increasingly prevalent elements of sexual and domestic violence prevention efforts, it is necessary to better understand the factors that support or impede individuals in taking positive action in the face of aggressive or disrespectful behavior from others. This study presents descriptive findings about the bystander experiences of 27 men who recently became involved in antiviolence against women work. More specifically, we describe the consistency with which respondents actively intervene in the speech or behavior of others, the strategies they use, and the factors they weigh as they deliberate taking action. Respondents report a complex and interrelated set of individual and contextual influences on their choices within bystander opportunities, which hold implications for both violence-specific models of bystander behavior and for prevention intervention development. PMID:21859757

Washington State Birth to 3 Plan: Building on Existing Efforts to Improve Services and Achieve Measurable Outcomes for Children and Families

ERIC Educational Resources Information Center

Washington State Department of Early Learning, 2010

2010-01-01

Washington State Department of Early Learning (DEL) contracted with Thrive by Five Washington to facilitate and write this report. A collaborative group of key stakeholders helped develop this plan, which consists of actionable policy recommendations in seven high-level focus areas. Within each area are specific "next steps" that build…

Decision-making for foot-and-mouth disease control: Objectives matter

USGS Publications Warehouse

Probert, William J. M.; Shea, Katriona; Fonnesbeck, Christopher J.; Runge, Michael C.; Carpenter, Tim E.; Durr, Salome; Garner, M. Graeme; Harvey, Neil; Stevenson, Mark A.; Webb, Colleen T.; Werkman, Marleen; Tildesley, Michael J.; Ferrari, Matthew J.

2016-01-01

Formal decision-analytic methods can be used to frame disease control problems, the first step of which is to define a clear and specific objective. We demonstrate the imperative of framing clearly-defined management objectives in finding optimal control actions for control of disease outbreaks. We illustrate an analysis that can be applied rapidly at the start of an outbreak when there are multiple stakeholders involved with potentially multiple objectives, and when there are also multiple disease models upon which to compare control actions. The output of our analysis frames subsequent discourse between policy-makers, modellers and other stakeholders, by highlighting areas of discord among different management objectives and also among different models used in the analysis. We illustrate this approach in the context of a hypothetical foot-and-mouth disease (FMD) outbreak in Cumbria, UK using outputs from five rigorously-studied simulation models of FMD spread. We present both relative rankings and relative performance of controls within each model and across a range of objectives. Results illustrate how control actions change across both the base metric used to measure management success and across the statistic used to rank control actions according to said metric. This work represents a first step towards reconciling the extensive modelling work on disease control problems with frameworks for structured decision making.

Leadership lessons from curricular change at the University of California, San Francisco, School of Medicine.

PubMed

Loeser, Helen; O'Sullivan, Patricia; Irby, David M

2007-04-01

After successive Liaison Committee on Medical Education accreditation reports that criticized the University of California, San Francisco, School of Medicine for lack of instructional innovation and curriculum oversight, the dean issued a mandate for curriculum reform in 1997. Could a medical school that prided itself on innovation in research and health care do the same in education? The authors describe their five-phase curriculum change process and correlate this to an eight-step leadership model. The first phase of curricular change is to establish a compelling need for change; it requires leaders to create a sense of urgency and build a guiding coalition to achieve action. The second phase of curriculum reform is to envision a bold new curriculum; leaders must develop such a vision and communicate it broadly. The third phase is to design curriculum and obtain the necessary approvals; this requires leaders to empower broad-based action and generate short-term wins. In the fourth phase, specific courses are developed for the new curriculum, and leaders continue to empower broad-based action, generate short-term wins, consolidate gains, and produce more change. During the fifth phase of implementation and evaluation, leaders need to further consolidate gains, produce more change, and anchor new approaches in the institution. Arising from this experience and the correlation of curricular change phases with leadership steps, the authors identify 27 specific leadership strategies they employed in their curricular reform process.

Gender Differences in Motor Skills of the Overarm Throw

PubMed Central

Gromeier, Michael; Koester, Dirk; Schack, Thomas

2017-01-01

In this cross-sectional study, the qualitative and quantitative throwing performance of male and female athletes (6 to 16 years of age) was analyzed. The goal of this study was to assess whether there were gender based qualitative and quantitative differences in throwing performance of young athletes, throughout three different age bands (childhood, pubescence, and adolescence). Furthermore, we explored whether all components of the throwing movement are equally affected by gender differences. Focus was placed on five essential components of action: trunk, forearm, humerus, stepping, and backswing. Therefore, children and adolescents (N = 96) were invited to throw three times from three different distances, while aiming at a target placed at shoulder height. The participants were aspiring athletes, competitive in the sport handball. For analyzing the quality of movement the component approach of Halverson and Roberton (1984) was used. The throwing accuracy was noted and used to evaluate the quantitative performance of the throwing movement. Throughout three different age bands, no statistically significant difference was found between genders in throwing accuracy, i.e., quantitative performance. Regarding the qualitative evaluation of the throwing movement, male and female athletes differed significantly. The component approach yielded higher scores for male than for female participants. As expected, with increasing age qualitative and quantitative performance of male and female athletes improved. These results suggest that there are gender-specific differences in qualitative throwing performance, but not necessarily in quantitative throwing performance. Exploration shows that differences in the qualitative throwing performance were seen in specific components of action. Male and female athletes demonstrated similar movement patterns in humerus and forearm actions, but differed in trunk, stepping, and backswing actions. PMID:28261142

When Networks Build a Platform Students Step up. Lumina Foundation Lesson. Spring 2010

ERIC Educational Resources Information Center

Brennan, Patricia L.

2010-01-01

For the people behind the Lumina Foundation for Education, the term "network" has particular meaning. In fact, largely as a result of their work in a national college awareness and action campaign called KnowHow2GO, they have come to define networks in a specific way--and they ask their KnowHow2GO grantees and partners to form networks…

Kinetically Defined Mechanisms and Positions of Action of Two New Modulators of Glucocorticoid Receptor-regulated Gene Induction*

PubMed Central

Pradhan, Madhumita A.; Blackford, John A.; Devaiah, Ballachanda N.; Thompson, Petria S.; Chow, Carson C.; Singer, Dinah S.; Simons, S. Stoney

2016-01-01

Most of the steps in, and many of the factors contributing to, glucocorticoid receptor (GR)-regulated gene induction are currently unknown. A competition assay, based on a validated chemical kinetic model of steroid hormone action, is now used to identify two new factors (BRD4 and negative elongation factor (NELF)-E) and to define their sites and mechanisms of action. BRD4 is a kinase involved in numerous initial steps of gene induction. Consistent with its complicated biochemistry, BRD4 is shown to alter both the maximal activity (Amax) and the steroid concentration required for half-maximal induction (EC50) of GR-mediated gene expression by acting at a minimum of three different kinetically defined steps. The action at two of these steps is dependent on BRD4 concentration, whereas the third step requires the association of BRD4 with P-TEFb. BRD4 is also found to bind to NELF-E, a component of the NELF complex. Unexpectedly, NELF-E modifies GR induction in a manner that is independent of the NELF complex. Several of the kinetically defined steps of BRD4 in this study are proposed to be related to its known biochemical actions. However, novel actions of BRD4 and of NELF-E in GR-controlled gene induction have been uncovered. The model-based competition assay is also unique in being able to order, for the first time, the sites of action of the various reaction components: GR < Cdk9 < BRD4 ≤ induced gene < NELF-E. This ability to order factor actions will assist efforts to reduce the side effects of steroid treatments. PMID:26504077

Storybridging: Four steps for constructing effective health narratives

PubMed Central

Boeijinga, Anniek; Hoeken, Hans; Sanders, José

2017-01-01

Objective: To develop a practical step-by-step approach to constructing narrative health interventions in response to the mixed results and wide diversity of narratives used in health-related narrative persuasion research. Method: Development work was guided by essential narrative characteristics as well as principles enshrined in the Health Action Process Approach. Results: The ‘storybridging’ method for constructing health narratives is described as consisting of four concrete steps: (a) identifying the stage of change, (b) identifying the key elements, (c) building the story, and (d) pre-testing the story. These steps are illustrated by means of a case study in which an effective narrative health intervention was developed for Dutch truck drivers: a high-risk, underprivileged occupational group. Conclusion: Although time and labour intensive, the Storybridging approach suggests integrating the target audience as an important stakeholder throughout the development process. Implications and recommendations are provided for health promotion targeting truck drivers specifically and for constructing narrative health interventions in general. PMID:29276232

A management approach that drives actions strategically: balanced scorecard in a mental health trust case study.

PubMed

Schmidt, Stefan; Bateman, Ian; Breinlinger-O'Reilly, Jochen; Smith, Peter

2006-01-01

Achieving excellence is a current preoccupation in U.K. public health organisations. This article aims to use a case study to explain how a mental health trust delivers excellent performance using a balanced scorecard (BSC) management approach. Reports a project to implement a BSC approach in the South West Yorkshire Mental Health NHS Trust to achieve its "excellence" objectives. The authors were participants in the project. The design of the pilot project was informed theoretically by the work of Kaplan and Norton and practically by in-house discussions on a strategy to achieve excellence. Explains the process of building a BSC strategy step-by-step. Discusses how the vision and strategies of a mental health trust can be translated into tangible measures, which are the basis for actions that are driven strategically. There are many possibilities for a BSC management approach and this case study is specific to mental health trusts in the UK, although it is believed that the case has a universally applicable modus operandi. This article will help healthcare managers to evaluate the benefits of a BSC management approach. This article explains how actions can be structured in connection with a BSC management approach.

A Neural Basis of Facial Action Recognition in Humans

PubMed Central

Srinivasan, Ramprakash; Golomb, Julie D.

2016-01-01

By combining different facial muscle actions, called action units, humans can produce an extraordinarily large number of facial expressions. Computational models and studies in cognitive science and social psychology have long hypothesized that the brain needs to visually interpret these action units to understand other people's actions and intentions. Surprisingly, no studies have identified the neural basis of the visual recognition of these action units. Here, using functional magnetic resonance imaging and an innovative machine learning analysis approach, we identify a consistent and differential coding of action units in the brain. Crucially, in a brain region thought to be responsible for the processing of changeable aspects of the face, multivoxel pattern analysis could decode the presence of specific action units in an image. This coding was found to be consistent across people, facilitating the estimation of the perceived action units on participants not used to train the multivoxel decoder. Furthermore, this coding of action units was identified when participants attended to the emotion category of the facial expression, suggesting an interaction between the visual analysis of action units and emotion categorization as predicted by the computational models mentioned above. These results provide the first evidence for a representation of action units in the brain and suggest a mechanism for the analysis of large numbers of facial actions and a loss of this capacity in psychopathologies. SIGNIFICANCE STATEMENT Computational models and studies in cognitive and social psychology propound that visual recognition of facial expressions requires an intermediate step to identify visible facial changes caused by the movement of specific facial muscles. Because facial expressions are indeed created by moving one's facial muscles, it is logical to assume that our visual system solves this inverse problem. Here, using an innovative machine learning method and neuroimaging data, we identify for the first time a brain region responsible for the recognition of actions associated with specific facial muscles. Furthermore, this representation is preserved across subjects. Our machine learning analysis does not require mapping the data to a standard brain and may serve as an alternative to hyperalignment. PMID:27098688

How the gastroenterology nurse can establish and meet career goals.

PubMed

Greenwald, Beverly

2006-01-01

A career goal promotes professional growth for the gastroenterology nurse. Short-term goals (achievable in less than one year) focus toward attaining a long-term goal (achievable in 5 to 10 years). The steps to achieving a career goal are self-assessment, career goal development, action plan development, implementation of the action plan, evaluation, and the establishment of a new goal. A career goal must be specific, measurable, achievable, realistic, and have a specified time frame. A tailor-made action plan is a list of interventions to promote goal achievement within the specified time frame. A goal posted in a prominent area is less likely to be forgotten and can guide day-to-day activities. A career goal should be reviewed and revised at least annually. A professional resume documents these career achievements.

Providing for the consideration of the resolution (H. Res. 251) directing the Secretary of the Treasury to transmit to the House of Representatives all information in his possession relating to specific communications with American International Group, Inc. (AIG).

THOMAS, 111th Congress

Rep. LaTourette, Steven C. [R-OH-14

2009-04-23

House - 05/07/2009 Motion to Discharge Committee filed by Mr. LaTourette. Petition No: 111-3. (All Actions) Notes: On 5/7/2009, a motion was filed to discharge the Committee on Rules from consideration of H.Res.359 a resolution providing for consideration of H.Res.251. A discharge petition requires 218 signatures for further action. (Discharge Petition No. 111-3: text with signatures.) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

School Climate Improvement Action Guide for District Leaders. School Climate Improvement Resource Package

ERIC Educational Resources Information Center

National Center on Safe Supportive Learning Environments, 2017

2017-01-01

Improving school climate takes time and commitment from a variety of people in a variety of roles. This document outlines key action steps that district leaders--including superintendents, assistant superintendents, directors of student support services, or others--can take to support school climate improvements. Key action steps are provided for…

Establishment of cells to monitor Microprocessor through fusion genes of microRNA and GFP

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tsutsui, Motomu; Hasegawa, Hitoki; Adachi, Koichi

Microprocessor, the complex of Drosha and DGCR8, promotes the processing of primary microRNA to precursor microRNA, which is a crucial step for microRNA maturation. So far, no convenient assay systems have been developed for observing this step in vivo. Here we report the establishment of highly sensitive cellular systems where we can visually monitor the function of Microprocessor. During a series of screening of transfectants with fusion genes of the EGFP cDNA and primary microRNA genes, we have obtained certain cell lines where introduction of siRNA against DGCR8 or Drosha strikingly augments GFP signals. In contrast, these cells have notmore » responded to Dicer siRNA; thus they have a unique character that GFP signals should be negatively and specifically correlated to the action of Microprocessor among biogenesis of microRNA. These cell lines can be useful tools for real-time analysis of Microprocessor action in vivo and identifying its novel modulators.« less

Locomotor adaptation is modulated by observing the actions of others

PubMed Central

Patel, Mitesh; Roberts, R. Edward; Riyaz, Mohammed U.; Ahmed, Maroof; Buckwell, David; Bunday, Karen; Ahmad, Hena; Kaski, Diego; Arshad, Qadeer

2015-01-01

Observing the motor actions of another person could facilitate compensatory motor behavior in the passive observer. Here we explored whether action observation alone can induce automatic locomotor adaptation in humans. To explore this possibility, we used the “broken escalator” paradigm. Conventionally this involves stepping upon a stationary sled after having previously experienced it actually moving (Moving trials). This history of motion produces a locomotor aftereffect when subsequently stepping onto a stationary sled. We found that viewing an actor perform the Moving trials was sufficient to generate a locomotor aftereffect in the observer, the size of which was significantly correlated with the size of the movement (postural sway) observed. Crucially, the effect is specific to watching the task being performed, as no motor adaptation occurs after simply viewing the sled move in isolation. These findings demonstrate that locomotor adaptation in humans can be driven purely by action observation, with the brain adapting motor plans in response to the size of the observed individual's motion. This mechanism may be mediated by a mirror neuron system that automatically adapts behavior to minimize movement errors and improve motor skills through social cues, although further neurophysiological studies are required to support this theory. These data suggest that merely observing the gait of another person in a challenging environment is sufficient to generate appropriate postural countermeasures, implying the existence of an automatic mechanism for adapting locomotor behavior. PMID:26156386

Toxicity and mode of action of insecticidal Cry1A proteins from Bacillus thuringiensis in an insect cell line, CF-1.

PubMed

Portugal, Leivi; Gringorten, J Lawrence; Caputo, Guido F; Soberón, Mario; Muñoz-Garay, Carlos; Bravo, Alejandra

2014-03-01

Bacillus thuringiensis Cry toxins are insecticidal proteins used to control insect pests. The interaction of Cry toxins with the midgut of susceptible insects is a dynamic process involving activation of the toxin, binding to midgut receptors in the apical epithelium and conformational changes in the toxin molecule, leading to pore formation and cell lysis. An understanding of the molecular events underlying toxin mode of action is essential for the continued use of Cry toxins. In this work, we examined the mechanism of action of Cry1A toxins in the lepidopteran cell line CF-1, using native Cry1Ab and mutant forms of this protein that interfer with different steps in the mechanism of action, specifically, receptor binding, oligomerization or pore formation. These mutants lost activity against both Manduca sexta larvae and CF-1 cells. We also analyzed a mutation created in domain I of Cry1Ab, in which helix α-1 and part of helix α-2 were deleted (Cry1AbMod). Cry1AbMod is able to oligomerize in the absence of toxin receptors, and although it shows reduced activity against some susceptible insects, it kills insect pests that have developed resistance to native Cry1Ab. Cry1AbMod showed enhanced toxicity to CF-1, suggesting that oligomerization of native Cry1Ab may be a limiting step in its activity against CF-1 cells. The toxicity of Cry1Ac and Cry1AcMod were also analyzed. Our results suggest that some of the steps in the mode of action of Cry1A toxins are conserved in vivo in insect midgut cells and in vitro in an established cell line, CF-1. Copyright © 2013 Elsevier Inc. All rights reserved.

Installation Restoration Program. Feasibility Study for Sites 1, 3, 5, 6, 7, 8, and 9. Michigan Air National Guard. Alpena Combat Readiness Training Center, Alpena, Michigan.

DTIC Science & Technology

1996-04-01

This study is to screen and evaluate remediation alternatives for IRP sites at Alpena CR TC, Alpena , MI. The purpose of this FS is to develop, screen... Alpena CRTC. The first step in the PS process is to identify the RAOs and general response actions (GRAs). RAOs consist of medium-specific or site

Heuristics and Biases in Military Decision Making

DTIC Science & Technology

2010-10-01

rationality and is based on a linear, step-based model that generates a specific course of action and is useful for the examination of problems that...exhibit stability and are underpinned by assumptions of “technical- rationality .”5 The Army values MDMP as the sanctioned approach for solving...theory) which sought to describe human behavior as a rational maximization of cost-benefit decisions, Kahne- man and Tversky provided a simple

National Advisory Commission on Work-Based Learning. Minutes of Full Commission Meeting (5th, Washington, District of Columbia, April 7, 1992).

ERIC Educational Resources Information Center

National Commission on Work-Based Learning (DOL), Washington, DC.

This document contains minutes of the fifth meeting of the National Advisory Commission on Work-Based Learning. The meeting's stated objective was to produce a set of specific action steps for the U.S. Department of Labor to promote work-based learning. A summary of introductory remarks (Jack MacAllister) is followed by a description of the…

A bill to amend the Hydrographic Services Improvement Act of 1998 to authorize funds to acquire hydrographic data and provide hydrographic services specific to the Arctic for safe navigation, delineating the United States extended continental shelf, and the monitoring and description of coastal changes.

THOMAS, 111th Congress

Sen. Murkowski, Lisa [R-AK

2009-07-24

Senate - 07/24/2009 Read twice and referred to the Committee on Commerce, Science, and Transportation. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

School Climate Improvement Action Guide for Instructional Staff. School Climate Improvement Resource Package

ERIC Educational Resources Information Center

National Center on Safe Supportive Learning Environments, 2017

2017-01-01

Improving school climate takes time and commitment from a variety of people in a variety of roles. This document outlines key action steps that instructional staff--including teachers, paraprofessionals, and others in the classroom who provide instruction or assistance--can take to support school climate improvements. Key action steps are provided…

School Climate Improvement Action Guide for School Leaders. School Climate Improvement Resource Package

ERIC Educational Resources Information Center

National Center on Safe Supportive Learning Environments, 2017

2017-01-01

Improving school climate takes time and commitment from a variety of people in a variety of roles. This document outlines key action steps that school leaders--including principals, assistant/vice principals, and building leaders--can take to support school climate improvements. Key action steps are provided for the following strategies: (1)…

School Climate Improvement Action Guide for Working with Students. School Climate Improvement Resource Package

ERIC Educational Resources Information Center

National Center on Safe Supportive Learning Environments, 2017

2017-01-01

Improving school climate takes time and commitment from a variety of people in a variety of roles. This document outlines key action steps to engage students in the school climate improvement process. Key action steps are provided for the following strategies: (1) Participate in planning for school climate improvements; (2) Engage stakeholders in…

Bridging the guideline implementation gap: a systematic, document-centered approach to guideline implementation.

PubMed

Shiffman, Richard N; Michel, George; Essaihi, Abdelwaheb; Thornquist, Elizabeth

2004-01-01

A gap exists between the information contained in published clinical practice guidelines and the knowledge and information that are necessary to implement them. This work describes a process to systematize and make explicit the translation of document-based knowledge into workflow-integrated clinical decision support systems. This approach uses the Guideline Elements Model (GEM) to represent the guideline knowledge. Implementation requires a number of steps to translate the knowledge contained in guideline text into a computable format and to integrate the information into clinical workflow. The steps include: (1) selection of a guideline and specific recommendations for implementation, (2) markup of the guideline text, (3) atomization, (4) deabstraction and (5) disambiguation of recommendation concepts, (6) verification of rule set completeness, (7) addition of explanations, (8) building executable statements, (9) specification of origins of decision variables and insertions of recommended actions, (10) definition of action types and selection of associated beneficial services, (11) choice of interface components, and (12) creation of requirement specification. The authors illustrate these component processes using examples drawn from recent experience translating recommendations from the National Heart, Lung, and Blood Institute's guideline on management of chronic asthma into a workflow-integrated decision support system that operates within the Logician electronic health record system. Using the guideline document as a knowledge source promotes authentic translation of domain knowledge and reduces the overall complexity of the implementation task. From this framework, we believe that a better understanding of activities involved in guideline implementation will emerge.

Neural circuitry coordinating male copulation

PubMed Central

Pavlou, Hania J; Lin, Andrew C; Neville, Megan C; Nojima, Tetsuya; Diao, Fengqiu; Chen, Brian E; White, Benjamin H; Goodwin, Stephen F

2016-01-01

Copulation is the goal of the courtship process, crucial to reproductive success and evolutionary fitness. Identifying the circuitry underlying copulation is a necessary step towards understanding universal principles of circuit operation, and how circuit elements are recruited into the production of ordered action sequences. Here, we identify key sex-specific neurons that mediate copulation in Drosophila, and define a sexually dimorphic motor circuit in the male abdominal ganglion that mediates the action sequence of initiating and terminating copulation. This sexually dimorphic circuit composed of three neuronal classes – motor neurons, interneurons and mechanosensory neurons – controls the mechanics of copulation. By correlating the connectivity, function and activity of these neurons we have determined the logic for how this circuitry is coordinated to generate this male-specific behavior, and sets the stage for a circuit-level dissection of active sensing and modulation of copulatory behavior. DOI: http://dx.doi.org/10.7554/eLife.20713.001 PMID:27855059

The Nurses Memorandum of 1938: A First Step in the Development of Action Learning?

ERIC Educational Resources Information Center

Bourner, Tom; Brook, Cheryl; Pedler, Mike

2018-01-01

This article concerns the origins of the idea of action learning, especially the claim by Revans that his Memorandum on "The Entry of Girls into the Nursing Profession" in Essex hospitals written in 1938 was the first step in the development of action learning. Whilst Revans repeatedly made this claim, there is no evidence in the actual…

Total synthesis and biological investigation of (-)-promysalin.

PubMed

Steele, Andrew D; Knouse, Kyle W; Keohane, Colleen E; Wuest, William M

2015-06-17

Compounds that specifically target pathogenic bacteria are greatly needed, and identifying the method by which they act would provide new avenues of treatment. Herein we report the concise, high-yielding total synthesis (eight steps, 35% yield) of promysalin, a natural product that displays antivirulence phenotypes against pathogenic bacteria. Guided by bioinformatics, four diastereomers were synthesized, and the relative and absolute stereochemistries were confirmed by spectral and biological analysis. Finally, we show for the first time that promysalin displays two antivirulence phenotypes: the dispersion of mature biofilms and the inhibition of pyoverdine production, hinting at a unique pathogenic-specific mechanism of action.

Applying mixture toxicity modelling to predict bacterial bioluminescence inhibition by non-specifically acting pharmaceuticals and specifically acting antibiotics.

PubMed

Neale, Peta A; Leusch, Frederic D L; Escher, Beate I

2017-04-01

Pharmaceuticals and antibiotics co-occur in the aquatic environment but mixture studies to date have mainly focused on pharmaceuticals alone or antibiotics alone, although differences in mode of action may lead to different effects in mixtures. In this study we used the Bacterial Luminescence Toxicity Screen (BLT-Screen) after acute (0.5 h) and chronic (16 h) exposure to evaluate how non-specifically acting pharmaceuticals and specifically acting antibiotics act together in mixtures. Three models were applied to predict mixture toxicity including concentration addition, independent action and the two-step prediction (TSP) model, which groups similarly acting chemicals together using concentration addition, followed by independent action to combine the two groups. All non-antibiotic pharmaceuticals had similar EC 50 values at both 0.5 and 16 h, indicating together with a QSAR (Quantitative Structure-Activity Relationship) analysis that they act as baseline toxicants. In contrast, the antibiotics' EC 50 values decreased by up to three orders of magnitude after 16 h, which can be explained by their specific effect on bacteria. Equipotent mixtures of non-antibiotic pharmaceuticals only, antibiotics only and both non-antibiotic pharmaceuticals and antibiotics were prepared based on the single chemical results. The mixture toxicity models were all in close agreement with the experimental results, with predicted EC 50 values within a factor of two of the experimental results. This suggests that concentration addition can be applied to bacterial assays to model the mixture effects of environmental samples containing both specifically and non-specifically acting chemicals. Copyright © 2017 Elsevier Ltd. All rights reserved.

Population of computational rabbit-specific ventricular action potential models for investigating sources of variability in cellular repolarisation.

PubMed

Gemmell, Philip; Burrage, Kevin; Rodriguez, Blanca; Quinn, T Alexander

2014-01-01

Variability is observed at all levels of cardiac electrophysiology. Yet, the underlying causes and importance of this variability are generally unknown, and difficult to investigate with current experimental techniques. The aim of the present study was to generate populations of computational ventricular action potential models that reproduce experimentally observed intercellular variability of repolarisation (represented by action potential duration) and to identify its potential causes. A systematic exploration of the effects of simultaneously varying the magnitude of six transmembrane current conductances (transient outward, rapid and slow delayed rectifier K(+), inward rectifying K(+), L-type Ca(2+), and Na(+)/K(+) pump currents) in two rabbit-specific ventricular action potential models (Shannon et al. and Mahajan et al.) at multiple cycle lengths (400, 600, 1,000 ms) was performed. This was accomplished with distributed computing software specialised for multi-dimensional parameter sweeps and grid execution. An initial population of 15,625 parameter sets was generated for both models at each cycle length. Action potential durations of these populations were compared to experimentally derived ranges for rabbit ventricular myocytes. 1,352 parameter sets for the Shannon model and 779 parameter sets for the Mahajan model yielded action potential duration within the experimental range, demonstrating that a wide array of ionic conductance values can be used to simulate a physiological rabbit ventricular action potential. Furthermore, by using clutter-based dimension reordering, a technique that allows visualisation of multi-dimensional spaces in two dimensions, the interaction of current conductances and their relative importance to the ventricular action potential at different cycle lengths were revealed. Overall, this work represents an important step towards a better understanding of the role that variability in current conductances may play in experimentally observed intercellular variability of rabbit ventricular action potential repolarisation.

Population of Computational Rabbit-Specific Ventricular Action Potential Models for Investigating Sources of Variability in Cellular Repolarisation

PubMed Central

Gemmell, Philip; Burrage, Kevin; Rodriguez, Blanca; Quinn, T. Alexander

2014-01-01

Variability is observed at all levels of cardiac electrophysiology. Yet, the underlying causes and importance of this variability are generally unknown, and difficult to investigate with current experimental techniques. The aim of the present study was to generate populations of computational ventricular action potential models that reproduce experimentally observed intercellular variability of repolarisation (represented by action potential duration) and to identify its potential causes. A systematic exploration of the effects of simultaneously varying the magnitude of six transmembrane current conductances (transient outward, rapid and slow delayed rectifier K+, inward rectifying K+, L-type Ca2+, and Na+/K+ pump currents) in two rabbit-specific ventricular action potential models (Shannon et al. and Mahajan et al.) at multiple cycle lengths (400, 600, 1,000 ms) was performed. This was accomplished with distributed computing software specialised for multi-dimensional parameter sweeps and grid execution. An initial population of 15,625 parameter sets was generated for both models at each cycle length. Action potential durations of these populations were compared to experimentally derived ranges for rabbit ventricular myocytes. 1,352 parameter sets for the Shannon model and 779 parameter sets for the Mahajan model yielded action potential duration within the experimental range, demonstrating that a wide array of ionic conductance values can be used to simulate a physiological rabbit ventricular action potential. Furthermore, by using clutter-based dimension reordering, a technique that allows visualisation of multi-dimensional spaces in two dimensions, the interaction of current conductances and their relative importance to the ventricular action potential at different cycle lengths were revealed. Overall, this work represents an important step towards a better understanding of the role that variability in current conductances may play in experimentally observed intercellular variability of rabbit ventricular action potential repolarisation. PMID:24587229

To amend the Hydrographic Services Improvement Act of 1998 to authorize funds to acquire hydrographic data and provide hydrographic services specific to the Arctic for safe navigation, delineating the United States extended continental shelf, and the monitoring and description of coastal changes.

THOMAS, 111th Congress

Rep. Young, Don [R-AK-At Large

2009-06-12

Senate - 07/15/2010 Received in the Senate and Read twice and referred to the Committee on Commerce, Science, and Transportation. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

To amend the Hydrographic Services Improvement Act of 1998 to authorize funds to acquire hydrographic data and provide hydrographic services specific to the Arctic for safe navigation, delineating the United States extended continental shelf, and the monitoring and description of coastal changes.

THOMAS, 112th Congress

Rep. Young, Don [R-AK-At Large

2011-01-12

Senate - 10/31/2011 Received in the Senate and Read twice and referred to the Committee on Commerce, Science, and Transportation. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

49 CFR 27.11 - Remedial action, voluntary action and compliance planning.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 1 2011-10-01 2011-10-01 false Remedial action, voluntary action and compliance....11 Remedial action, voluntary action and compliance planning. (a) Remedial action. (1) If the... discrimination not occurred. (b) Voluntary action. A recipient may take steps, in addition to any action that is...

Does my step look big in this? A visual illusion leads to safer stepping behaviour.

PubMed

Elliott, David B; Vale, Anna; Whitaker, David; Buckley, John G

2009-01-01

Tripping is a common factor in falls and a typical safety strategy to avoid tripping on steps or stairs is to increase foot clearance over the step edge. In the present study we asked whether the perceived height of a step could be increased using a visual illusion and whether this would lead to the adoption of a safer stepping strategy, in terms of greater foot clearance over the step edge. The study also addressed the controversial question of whether motor actions are dissociated from visual perception. 21 young, healthy subjects perceived the step to be higher in a configuration of the horizontal-vertical illusion compared to a reverse configuration (p = 0.01). During a simple stepping task, maximum toe elevation changed by an amount corresponding to the size of the visual illusion (p<0.001). Linear regression analyses showed highly significant associations between perceived step height and maximum toe elevation for all conditions. The perceived height of a step can be manipulated using a simple visual illusion, leading to the adoption of a safer stepping strategy in terms of greater foot clearance over a step edge. In addition, the strong link found between perception of a visual illusion and visuomotor action provides additional support to the view that the original, controversial proposal by Goodale and Milner (1992) of two separate and distinct visual streams for perception and visuomotor action should be re-evaluated.

Quality maternity care for every woman, everywhere: a call to action.

PubMed

Koblinsky, Marjorie; Moyer, Cheryl A; Calvert, Clara; Campbell, James; Campbell, Oona M R; Feigl, Andrea B; Graham, Wendy J; Hatt, Laurel; Hodgins, Steve; Matthews, Zoe; McDougall, Lori; Moran, Allisyn C; Nandakumar, Allyala K; Langer, Ana

2016-11-05

To improve maternal health requires action to ensure quality maternal health care for all women and girls, and to guarantee access to care for those outside the system. In this paper, we highlight some of the most pressing issues in maternal health and ask: what steps can be taken in the next 5 years to catalyse action toward achieving the Sustainable Development Goal target of less than 70 maternal deaths per 100 000 livebirths by 2030, with no single country exceeding 140? What steps can be taken to ensure that high-quality maternal health care is prioritised for every woman and girl everywhere? We call on all stakeholders to work together in securing a healthy, prosperous future for all women. National and local governments must be supported by development partners, civil society, and the private sector in leading efforts to improve maternal-perinatal health. This effort means dedicating needed policies and resources, and sustaining implementation to address the many factors influencing maternal health-care provision and use. Five priority actions emerge for all partners: prioritise quality maternal health services that respond to the local specificities of need, and meet emerging challenges; promote equity through universal coverage of quality maternal health services, including for the most vulnerable women; increase the resilience and strength of health systems by optimising the health workforce, and improve facility capability; guarantee sustainable finances for maternal-perinatal health; and accelerate progress through evidence, advocacy, and accountability. Copyright © 2016 Elsevier Ltd. All rights reserved.

24 CFR 55.12 - Inapplicability of 24 CFR part 55 to certain categories of proposed actions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... proposed actions. (a) The decision making steps in § 55.20 (b), (c) and (g) (steps 2, 3 and 7) shall not... the footprint of the structure and paved areas is not significantly increased. (b) The decision making...'s actions under section 223(f) of the National Housing Act (12 U.S.C. 1715n(f)) for the purchase or...

Cyberspace Actions in a Counterinsurgency

DTIC Science & Technology

2016-06-01

provides a benefit in their efforts to strengthen HN rule of law. As a result, the FBI has developed a Cyber Assistant Legal Attaché (ALAT) system ...draft this type of doctrine. The first is that the nation’s political and military leadership is unable to make the transition to a COIN strategy that is...little specific or even generalized examples of what this would look like (Ringdahl 2010, 7). Fidier takes a step in the direction of providing a

A resolution recognizing that the occurrence of prostate cancer in African-American men has reached epidemic proportions and urging Federal agencies to address that health crisis by supporting education, awareness outreach, and research specifically focused on how prostate cancer affects African-American men.

THOMAS, 112th Congress

Sen. Kerry, John F. [D-MA

2012-07-26

Senate - 07/26/2012 Submitted in the Senate, considered, and agreed to without amendment and with a preamble by Unanimous Consent. (All Actions) Tracker: This bill has the status Agreed to in SenateHere are the steps for Status of Legislation:

Thinking Systemically: Steps for States to Improve Equity in the Distribution of Teachers-- An Action-Planning Workbook to Help Guide Regional Comprehensive Center and State Education Agency Conversation to Address the Inequitable Distribution of Teachers

ERIC Educational Resources Information Center

National Comprehensive Center for Teacher Quality, 2009

2009-01-01

The National Comprehensive Center for Teacher Quality (TQ Center) is a resource to which the regional comprehensive centers, states, and other education stakeholders turn for strengthening the quality of teaching--especially in high-poverty, low-performing, and hard-to-staff schools--and for finding guidance in addressing specific needs, thereby…

Effects of intensity on muscle-specific voluntary electromechanical delay and relaxation electromechanical delay.

PubMed

Smith, Cory M; Housh, Terry J; Hill, Ethan C; Keller, Josh L; Johnson, Glen O; Schmidt, Richard J

2018-06-01

The purposes of this study were to examine: 1) the potential muscle-specific differences in voluntary electromechanical delay (EMD) and relaxation electromechanical delay (R-EMD), and 2) the effects of intensity on EMD and R-EMD during step incremental isometric muscle actions from 10 to 100% maximal voluntary isometric contraction (MVIC). EMD and R-EMD measures were calculated from the simultaneous assessments of electromyography, mechanomyography, and force production from the vastus lateralis (VL), vastus medialis (VM), and rectus femoris (RF) during step isometric muscle actions. There were no differences between the VL, VM, and RF for the voluntary EMD E-M (onsets of the electromyographic to mechanomyographic signals), EMD M-F (onsets the mechanomyographic to force production), or EMD E-F (onsets of the electromyographic signal to force production) as well as R-EMD E-M (cessation of electromyographic to mechanomyographic signal), R-EMD M-F (cessation of mechanomyographic signal to force cessation), or R-EMD E-F (cessation of electromyorgraphic signal to force cessation) at any intensity. There were decreases in all EMD and R-EMD measures with increases in intensity. The relative contributions from EMD E-M and EMD M-F to EMD E-F as well as R-EMD E-M and R-EMD M-F to R-EMD E-F remained similar across all intensities. The superficial muscles of the quadriceps femoris shared similar EMD and R-EMD measurements.

Effect of hypoxia on specific dynamic action and postprandial cardiovascular physiology in rainbow trout (Oncorhynchus mykiss).

PubMed

Eliason, Erika J; Farrell, Anthony P

2014-05-01

Fish routinely encounter hypoxic environments, which may have detrimental effects on digestion and performance. The present study measured oxygen consumption (MO2), gastrointestinal blood flow (GBF), cardiac output (Vb) and heart rate (f(H)) in rainbow trout Oncorhynchus mykiss at 10°C-11.5°C while exposed to a 1.5-h step-wise hypoxia treatment (80%, 60% and 40% saturation=16.7, 12.6 and 8.4 kPa, respectively), which began 4 h after being fed 1% of their body mass. GBF and f(H) significantly decreased by 41 and 25%-29%, respectively, at the most severe hypoxia step (40% saturation), while MO2 and Vb were maintained throughout the entire hypoxia exposure. Thus, GBF and f(H) were more sensitive to hypoxia than MO2 or Vb in digesting rainbow trout. Subsequent to the hypoxic exposure, the fish were returned to normoxia and monitored for a total of 50h after feeding. While the magnitude of SDA was unaffected, peak postprandial MO2 was reduced by 17%, and the duration of specific dynamic action (SDA) was prolonged by 6h in hypoxia-treated fish when compared to control fish. In conclusion, digestive performance was compromised both during and after the hypoxic exposure, which could lead to negative effects on growth. Copyright © 2014 Elsevier Inc. All rights reserved.

Eighth International Chorea-Acanthocytosis Symposium: Summary of Workshop Discussion and Action Points.

PubMed

Pappas, Samuel S; Bonifacino, Juan; Danek, Adrian; Dauer, William T; De, Mithu; De Franceschi, Lucia; DiPaolo, Gilbert; Fuller, Robert; Haucke, Volker; Hermann, Andreas; Kornmann, Benoit; Landwehrmeyer, Bernhard; Levin, Johannes; Neiman, Aaron M; Rudnicki, Dobrila D; Sibon, Ody; Velayos-Baeza, Antonio; Vonk, Jan J; Walker, Ruth H; Weisman, Lois S; Albin, Roger L

2017-01-01

Chorea-Acanthocytosis (ChAc) is a rare hereditary neurological disorder characterized by abnormal movements, red blood cell pathology, and progressive neurodegeneration. Little is understood of the pathogenesis of ChAc and related disorders (collectively Neuroacanthocytosis). The Eighth International Chorea-Acanthocytosis Symposium was held in May 2016 in Ann Arbor, MI, USA, and focused on molecular mechanisms driving ChAc pathophysiology. Accompanying the meeting, members of the neuroacanthocytosis research community and other invited scientists met in a workshop to discuss the current understanding and next steps needed to better understand ChAc pathogenesis. These discussions identified several broad and critical needs for advancing ChAc research and patient care, and led to the definition of 18 specific action points related to functional and molecular studies, animal models, and clinical research. These action points, described below, represent tractable research goals to pursue for the next several years.

Report on Action Research: An Analysis of the Effects of a Six Step Approach to Direct Vocabulary Instruction on Student Achievement at the Elementary School Level

ERIC Educational Resources Information Center

Haystead, Mark W.

2009-01-01

This report describes the findings of an analysis of a series of action research projects conducted by Goshen Community Schools at the elementary school level. During the 2008-2009 school year, 26 teachers at 7 elementary schools participated in independent action research studies regarding the extent to which a six step approach to direct…

Bridging the Guideline Implementation Gap: A Systematic, Document-Centered Approach to Guideline Implementation

PubMed Central

Shiffman, Richard N.; Michel, George; Essaihi, Abdelwaheb; Thornquist, Elizabeth

2004-01-01

Objective: A gap exists between the information contained in published clinical practice guidelines and the knowledge and information that are necessary to implement them. This work describes a process to systematize and make explicit the translation of document-based knowledge into workflow-integrated clinical decision support systems. Design: This approach uses the Guideline Elements Model (GEM) to represent the guideline knowledge. Implementation requires a number of steps to translate the knowledge contained in guideline text into a computable format and to integrate the information into clinical workflow. The steps include: (1) selection of a guideline and specific recommendations for implementation, (2) markup of the guideline text, (3) atomization, (4) deabstraction and (5) disambiguation of recommendation concepts, (6) verification of rule set completeness, (7) addition of explanations, (8) building executable statements, (9) specification of origins of decision variables and insertions of recommended actions, (10) definition of action types and selection of associated beneficial services, (11) choice of interface components, and (12) creation of requirement specification. Results: The authors illustrate these component processes using examples drawn from recent experience translating recommendations from the National Heart, Lung, and Blood Institute's guideline on management of chronic asthma into a workflow-integrated decision support system that operates within the Logician electronic health record system. Conclusion: Using the guideline document as a knowledge source promotes authentic translation of domain knowledge and reduces the overall complexity of the implementation task. From this framework, we believe that a better understanding of activities involved in guideline implementation will emerge. PMID:15187061

Identification of Carboxypeptidase Substrates by C-Terminal COFRADIC.

PubMed

Tanco, Sebastian; Aviles, Francesc Xavier; Gevaert, Kris; Lorenzo, Julia; Van Damme, Petra

2017-01-01

We here present a detailed procedure for studying protein C-termini and their posttranslational modifications by C-terminal COFRADIC. In fact, this procedure can enrich for both C-terminal and N-terminal peptides through a combination of a strong cation exchange fractionation step at low pH, which removes the majority of nonterminal peptides in whole-proteome digests, while the actual COFRADIC step segregates C-terminal peptides from N-terminal peptides. When used in a differential mode, C-terminal COFRADIC allows for the identification of neo-C-termini generated by the action of proteases, which in turn leads to the identification of protease substrates. More specifically, this technology can be applied to determine the natural substrate repertoire of carboxypeptidases on a proteome-wide scale.

Environmental Action Energy Conservation. Teacher Resource Guide.

ERIC Educational Resources Information Center

1998

The environmental education curriculum called Environment ACTION is designed to empower students with the knowledge and skills necessary to make meaningful environmental changes. This module provides step-by-step instructions on how to explore the sources, production, uses, and environmental effects of energy in their schools and home. There are…

Inside the Black Box: Tracking Decision-Making in an Action Research Study

ERIC Educational Resources Information Center

Smith, Cathryn

2017-01-01

Action research has been described as "designing the plane while flying it" (Herr & Anderson, 2005, p. 69). A black box documented the researcher's decisions while facilitating leadership development sessions with teacher leaders. Ten process folio steps informed the study through six iterations. Planning steps included a design…

Pure field theories and MACSYMA algorithms

NASA Technical Reports Server (NTRS)

Ament, W. S.

1977-01-01

A pure field theory attempts to describe physical phenomena through singularity-free solutions of field equations resulting from an action principle. The physics goes into forming the action principle and interpreting specific results. Algorithms for the intervening mathematical steps are sketched. Vacuum general relativity is a pure field theory, serving as model and providing checks for generalizations. The fields of general relativity are the 10 components of a symmetric Riemannian metric tensor; those of the Einstein-Straus generalization are the 16 components of a nonsymmetric. Algebraic properties are exploited in top level MACSYMA commands toward performing some of the algorithms of that generalization. The light cone for the theory as left by Einstein and Straus is found and simplifications of that theory are discussed.

Last-position elimination-based learning automata.

PubMed

Zhang, Junqi; Wang, Cheng; Zhou, MengChu

2014-12-01

An update scheme of the state probability vector of actions is critical for learning automata (LA). The most popular is the pursuit scheme that pursues the estimated optimal action and penalizes others. This paper proposes a reverse philosophy that leads to last-position elimination-based learning automata (LELA). The action graded last in terms of the estimated performance is penalized by decreasing its state probability and is eliminated when its state probability becomes zero. All active actions, that is, actions with nonzero state probability, equally share the penalized state probability from the last-position action at each iteration. The proposed LELA is characterized by the relaxed convergence condition for the optimal action, the accelerated step size of the state probability update scheme for the estimated optimal action, and the enriched sampling for the estimated nonoptimal actions. The proof of the ϵ-optimal property for the proposed algorithm is presented. Last-position elimination is a widespread philosophy in the real world and has proved to be also helpful for the update scheme of the learning automaton via the simulations of well-known benchmark environments. In the simulations, two versions of the LELA, using different selection strategies of the last action, are compared with the classical pursuit algorithms Discretized Pursuit Reward-Inaction (DP(RI)) and Discretized Generalized Pursuit Algorithm (DGPA). Simulation results show that the proposed schemes achieve significantly faster convergence and higher accuracy than the classical ones. Specifically, the proposed schemes reduce the interval to find the best parameter for a specific environment in the classical pursuit algorithms. Thus, they can have their parameter tuning easier to perform and can save much more time when applied to a practical case. Furthermore, the convergence curves and the corresponding variance coefficient curves of the contenders are illustrated to characterize their essential differences and verify the analysis results of the proposed algorithms.

Transport and pharmacodynamics of albitiazolium, an antimalarial drug candidate

PubMed Central

Wein, S; Maynadier, M; Bordat, Y; Perez, J; Maheshwari, S; Bette-Bobillo, P; Tran Van Ba, C; Penarete-Vargas, D; Fraisse, L; Cerdan, R; Vial, H

2012-01-01

BACKGROUND AND PURPOSE Choline analogues, a new type of antimalarials, exert potent in vitro and in vivo antimalarial activity. This has given rise to albitiazolium, which is currently in phase II clinical trials to cure severe malaria. Here we dissected its mechanism of action step by step from choline entry into the infected erythrocyte to its effect on phosphatidylcholine (PC) biosynthesis. EXPERIMENTAL APPROACH We biochemically unravelled the transport and enzymatic steps that mediate de novo synthesis of PC and elucidated how albitiazolium enters the intracellular parasites and affects the PC biosynthesis. KEY RESULTS Choline entry into Plasmodium falciparum-infected erythrocytes is achieved both by the remnant erythrocyte choline carrier and by parasite-induced new permeability pathways (NPP), while parasite entry involves a poly-specific cation transporter. Albitiazolium specifically prevented choline incorporation into its end-product PC, and its antimalarial activity was strongly antagonized by choline. Albitiazolium entered the infected erythrocyte mainly via a furosemide-sensitive NPP and was transported into the parasite by a poly-specific cation carrier. Albitiazolium competitively inhibited choline entry via the parasite-derived cation transporter and also, at a much higher concentration, affected each of the three enzymes conducting de novo synthesis of PC. CONCLUSIONS AND IMPLICATIONS Inhibition of choline entry into the parasite appears to be the primary mechanism by which albitiazolium exerts its potent antimalarial effect. However, the pharmacological response to albitiazolium involves molecular interactions with different steps of the de novo PC biosynthesis pathway, which would help to delay the development of resistance to this drug. PMID:22471905

Timing paradox of stepping and falls in ageing: not so quick and quick(er) on the trigger

PubMed Central

Mille, Marie‐Laure

2016-01-01

Abstract Physiological and degenerative changes affecting human standing balance are major contributors to falls with ageing. During imbalance, stepping is a powerful protective action for preserving balance that may be voluntarily initiated in recognition of a balance threat, or be induced by an externally imposed mechanical or sensory perturbation. Paradoxically, with ageing and falls, initiation slowing of voluntary stepping is observed together with perturbation‐induced steps that are triggered as fast as or faster than for younger adults. While age‐associated changes in sensorimotor conduction, central neuronal processing and cognitive functions are linked to delayed voluntary stepping, alterations in the coupling of posture and locomotion may also prolong step triggering. It is less clear, however, how these factors may explain the accelerated triggering of induced stepping. We present a conceptual model that addresses this issue. For voluntary stepping, a disruption in the normal coupling between posture and locomotion may underlie step‐triggering delays through suppression of the locomotion network based on an estimation of the evolving mechanical state conditions for stability. During induced stepping, accelerated step initiation may represent an event‐triggering process whereby stepping is released according to the occurrence of a perturbation rather than to the specific sensorimotor information reflecting the evolving instability. In this case, errors in the parametric control of induced stepping and its effectiveness in stabilizing balance would be likely to occur. We further suggest that there is a residual adaptive capacity with ageing that could be exploited to improve paradoxical triggering and other changes in protective stepping to impact fall risk. PMID:26915664

38 CFR 18.406 - Remedial action, voluntary action and self-evaluation.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., voluntary action and self-evaluation. 18.406 Section 18.406 Pensions, Bonuses, and Veterans' Relief... Basis of Handicap General Provisions § 18.406 Remedial action, voluntary action and self-evaluation. (a... treatment within the program or activity. (b) Voluntary action. A recipient may take steps, in addition to...

38 CFR 18.406 - Remedial action, voluntary action and self-evaluation.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., voluntary action and self-evaluation. 18.406 Section 18.406 Pensions, Bonuses, and Veterans' Relief... Basis of Handicap General Provisions § 18.406 Remedial action, voluntary action and self-evaluation. (a... treatment within the program or activity. (b) Voluntary action. A recipient may take steps, in addition to...

38 CFR 18.406 - Remedial action, voluntary action and self-evaluation.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., voluntary action and self-evaluation. 18.406 Section 18.406 Pensions, Bonuses, and Veterans' Relief... Basis of Handicap General Provisions § 18.406 Remedial action, voluntary action and self-evaluation. (a... treatment within the program or activity. (b) Voluntary action. A recipient may take steps, in addition to...

38 CFR 18.406 - Remedial action, voluntary action and self-evaluation.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., voluntary action and self-evaluation. 18.406 Section 18.406 Pensions, Bonuses, and Veterans' Relief... Basis of Handicap General Provisions § 18.406 Remedial action, voluntary action and self-evaluation. (a... treatment within the program or activity. (b) Voluntary action. A recipient may take steps, in addition to...

77 FR 26929 - Requirements for Official Establishments To Notify FSIS of Adulterated or Misbranded Product...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-08

... Inspection Service, USDA. ACTION: Final rule. SUMMARY: The Food Safety and Inspection Service (FSIS) is... that outlines a step-by-step reaction process. They also requested that FSIS consider factors such as... to determine more quickly whether a recall action is necessary (including detention and seizure of...

Disentangling the Roles of Approach, Activation and Valence in Instrumental and Pavlovian Responding

PubMed Central

Huys, Quentin J. M.; Cools, Roshan; Gölzer, Martin; Friedel, Eva; Heinz, Andreas; Dolan, Raymond J.; Dayan, Peter

2011-01-01

Hard-wired, Pavlovian, responses elicited by predictions of rewards and punishments exert significant benevolent and malevolent influences over instrumentally-appropriate actions. These influences come in two main groups, defined along anatomical, pharmacological, behavioural and functional lines. Investigations of the influences have so far concentrated on the groups as a whole; here we take the critical step of looking inside each group, using a detailed reinforcement learning model to distinguish effects to do with value, specific actions, and general activation or inhibition. We show a high degree of sophistication in Pavlovian influences, with appetitive Pavlovian stimuli specifically promoting approach and inhibiting withdrawal, and aversive Pavlovian stimuli promoting withdrawal and inhibiting approach. These influences account for differences in the instrumental performance of approach and withdrawal behaviours. Finally, although losses are as informative as gains, we find that subjects neglect losses in their instrumental learning. Our findings argue for a view of the Pavlovian system as a constraint or prior, facilitating learning by alleviating computational costs that come with increased flexibility. PMID:21556131

Phase I Hydrologic Data for the Groundwater Flow and Contaminant Transport Model of Corrective Action Unit 97: Yucca Flat/Climax Mine, Nevada Test Site, Nye County, Nevada, Rev. No.: 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

John McCord

2006-06-01

The U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (NNSA/NSO) initiated the Underground Test Area (UGTA) Project to assess and evaluate the effects of the underground nuclear weapons tests on groundwater beneath the Nevada Test Site (NTS) and vicinity. The framework for this evaluation is provided in Appendix VI, Revision No. 1 (December 7, 2000) of the Federal Facility Agreement and Consent Order (FFACO, 1996). Section 3.0 of Appendix VI ''Corrective Action Strategy'' of the FFACO describes the process that will be used to complete corrective actions specifically for the UGTA Project. The objective of themore » UGTA corrective action strategy is to define contaminant boundaries for each UGTA corrective action unit (CAU) where groundwater may have become contaminated from the underground nuclear weapons tests. The contaminant boundaries are determined based on modeling of groundwater flow and contaminant transport. A summary of the FFACO corrective action process and the UGTA corrective action strategy is provided in Section 1.5. The FFACO (1996) corrective action process for the Yucca Flat/Climax Mine CAU 97 was initiated with the Corrective Action Investigation Plan (CAIP) (DOE/NV, 2000a). The CAIP included a review of existing data on the CAU and proposed a set of data collection activities to collect additional characterization data. These recommendations were based on a value of information analysis (VOIA) (IT, 1999), which evaluated the value of different possible data collection activities, with respect to reduction in uncertainty of the contaminant boundary, through simplified transport modeling. The Yucca Flat/Climax Mine CAIP identifies a three-step model development process to evaluate the impact of underground nuclear testing on groundwater to determine a contaminant boundary (DOE/NV, 2000a). The three steps are as follows: (1) Data compilation and analysis that provides the necessary modeling data that is completed in two parts: the first addressing the groundwater flow model, and the second the transport model. (2) Development of a groundwater flow model. (3) Development of a groundwater transport model. This report presents the results of the first part of the first step, documenting the data compilation, evaluation, and analysis for the groundwater flow model. The second part, documentation of transport model data will be the subject of a separate report. The purpose of this document is to present the compilation and evaluation of the available hydrologic data and information relevant to the development of the Yucca Flat/Climax Mine CAU groundwater flow model, which is a fundamental tool in the prediction of the extent of contaminant migration. Where appropriate, data and information documented elsewhere are summarized with reference to the complete documentation. The specific task objectives for hydrologic data documentation are as follows: (1) Identify and compile available hydrologic data and supporting information required to develop and validate the groundwater flow model for the Yucca Flat/Climax Mine CAU. (2) Assess the quality of the data and associated documentation, and assign qualifiers to denote levels of quality. (3) Analyze the data to derive expected values or spatial distributions and estimates of the associated uncertainty and variability.« less

A new approach for bioassays based on frequency- and time-domain measurements of magnetic nanoparticles.

PubMed

Oisjöen, Fredrik; Schneiderman, Justin F; Astalan, Andrea Prieto; Kalabukhov, Alexey; Johansson, Christer; Winkler, Dag

2010-01-15

We demonstrate a one-step wash-free bioassay measurement system capable of tracking biochemical binding events. Our approach combines the high resolution of frequency- and high speed of time-domain measurements in a single device in combination with a fast one-step bioassay. The one-step nature of our magnetic nanoparticle (MNP) based assay reduces the time between sample extraction and quantitative results while mitigating the risks of contamination related to washing steps. Our method also enables tracking of binding events, providing the possibility of, for example, investigation of how chemical/biological environments affect the rate of a binding process or study of the action of certain drugs. We detect specific biological binding events occurring on the surfaces of fluid-suspended MNPs that modify their magnetic relaxation behavior. Herein, we extrapolate a modest sensitivity to analyte of 100 ng/ml with the present setup using our rapid one-step bioassay. More importantly, we determine the size-distributions of the MNP systems with theoretical fits to our data obtained from the two complementary measurement modalities and demonstrate quantitative agreement between them. Copyright 2009 Elsevier B.V. All rights reserved.

5 CFR 531.508 - Evaluation of quality step increase authority.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Evaluation of quality step increase... REGULATIONS PAY UNDER THE GENERAL SCHEDULE Quality Step Increases § 531.508 Evaluation of quality step... grant quality step increases. The agency shall take any corrective action required by the Office. [60 FR...

Auditory cueing in Parkinson's patients with freezing of gait. What matters most: Action-relevance or cue-continuity?

PubMed

Young, William R; Shreve, Lauren; Quinn, Emma Jane; Craig, Cathy; Bronte-Stewart, Helen

2016-07-01

Gait disturbances are a common feature of Parkinson's disease, one of the most severe being freezing of gait. Sensory cueing is a common method used to facilitate stepping in people with Parkinson's. Recent work has shown that, compared to walking to a metronome, Parkinson's patients without freezing of gait (nFOG) showed reduced gait variability when imitating recorded sounds of footsteps made on gravel. However, it is not known if these benefits are realised through the continuity of the acoustic information or the action-relevance. Furthermore, no study has examined if these benefits extend to PD with freezing of gait. We prepared four different auditory cues (varying in action-relevance and acoustic continuity) and asked 19 Parkinson's patients (10 nFOG, 9 with freezing of gait (FOG)) to step in place to each cue. Results showed a superiority of action-relevant cues (regardless of cue-continuity) for inducing reductions in Step coefficient of variation (CV). Acoustic continuity was associated with a significant reduction in Swing CV. Neither cue-continuity nor action-relevance was independently sufficient to increase the time spent stepping before freezing. However, combining both attributes in the same cue did yield significant improvements. This study demonstrates the potential of using action-sounds as sensory cues for Parkinson's patients with freezing of gait. We suggest that the improvements shown might be considered audio-motor 'priming' (i.e., listening to the sounds of footsteps will engage sensorimotor circuitry relevant to the production of that same action, thus effectively bypassing the defective basal ganglia). Copyright © 2016. Published by Elsevier Ltd.

Restoration handbook for sagebrush steppe ecosystems with emphasis on greater sage-grouse habitat—Part 3. Site level restoration decisions

USGS Publications Warehouse

Pyke, David A.; Chambers, Jeanne C.; Pellant, Mike; Miller, Richard F.; Beck, Jeffrey L.; Doescher, Paul S.; Roundy, Bruce A.; Schupp, Eugene W.; Knick, Steven T.; Brunson, Mark; McIver, James D.

2017-02-14

Sagebrush steppe ecosystems in the United States currently (2016) occur on only about one-half of their historical land area because of changes in land use, urban growth, and degradation of land, including invasions of non-native plants. The existence of many animal species depends on the existence of sagebrush steppe habitat. The greater sage-grouse (Centrocercus urophasianus) depends on large landscapes of intact habitat of sagebrush and perennial grasses for their existence. In addition, other sagebrush-obligate animals have similar requirements and restoration of landscapes for greater sage-grouse also will benefit these animals. Once sagebrush lands are degraded, they may require restoration actions to make those lands viable habitat for supporting sagebrush-obligate animals, livestock, and wild horses, and to provide ecosystem services for humans now and for future generations.When a decision is made on where restoration treatments should be applied, there are a number of site-specific decisions managers face before selecting the appropriate type of restoration. This site-level decision tool for restoration of sagebrush steppe ecosystems is organized in nine steps.Step 1 describes the process of defining site-level restoration objectives.Step 2 describes the ecological site characteristics of the restoration site. This covers soil chemistry and texture, soil moisture and temperature regimes, and the vegetation communities the site is capable of supporting.Step 3 compares the current vegetation to the plant communities associated with the site State and Transition models.Step 4 takes the manager through the process of current land uses and past disturbances that may influence restoration success.Step 5 is a brief discussion of how weather before and after treatments may impact restoration success.Step 6 addresses restoration treatment types and their potential positive and negative impacts on the ecosystem and on habitats, especially for greater sage-grouse. We discuss when passive restoration options may be sufficient and when active restoration may be necessary to achieve restoration objectives.Step 7 addresses decisions regarding post-restoration livestock grazing management.Step 8 addresses monitoring of the restoration; we discuss important aspects associated with implementation monitoring as well as effectiveness monitoring.Step 9 takes the information learned from monitoring to determine how restoration actions in the future might be adapted to improve restoration success.

Pyrrhocoricin, a proline-rich antimicrobial peptide derived from insect, inhibits the translation process in the cell-free Escherichia coli protein synthesis system.

PubMed

Taniguchi, Masayuki; Ochiai, Akihito; Kondo, Hiroshi; Fukuda, Shun; Ishiyama, Yohei; Saitoh, Eiichi; Kato, Tetsuo; Tanaka, Takaaki

2016-05-01

Previous studies have shown that pyrrhocoricin, a proline-rich antimicrobial peptide (PrAMP), killed sensitive species in a dose-dependent manner by specifically binding to DnaK. Here, on the basis of the finding that DnaK-deficient Escherichia coli strains are susceptible to PrAMPs, we used pyrrhocoricin to investigate internal targets other than DnaK. Using conventional antibiotics (bleomycin, streptomycin, and fosfomycin) that have known modes of action, first, we validated the availability of an assay using a cell-free rapid translation system (RTS), which is an in vitro protein synthesis system based on E. coli lysate, for evaluating inhibition of protein synthesis. We found that, similarly to bleomycin and streptomycin, pyrrhocoricin inhibited GFP synthesis in RTS in a concentration-dependent manner. In addition, blockage of transcription and translation steps in RTS was individually estimated using RT-PCR after gene expression to determine mRNA products and using sodium dodecyl sulfate-polyacrylamide gel electrophoresis to determine the amounts of GFP expressed from purified mRNA, respectively. The results demonstrated that this inhibition of GFP synthesis by pyrrhocoricin did not occur at the transcription step but rather at the translation step, in a manner similar to that of GFP synthesis by streptomycin, an inhibitor of the translation step by causing misreading of tRNA. These results suggest that RTS is a powerful assay system for determining if antimicrobial peptides inhibit protein synthesis and its transcription and/or translation steps. This is the first study to have shown that pyrrhocoricin inhibited protein synthesis by specifically repressing the translation step. Copyright © 2015 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

Two-step adaptive management for choosing between two management actions

USGS Publications Warehouse

Moore, Alana L.; Walker, Leila; Runge, Michael C.; McDonald-Madden, Eve; McCarthy, Michael A

2017-01-01

Adaptive management is widely advocated to improve environmental management. Derivations of optimal strategies for adaptive management, however, tend to be case specific and time consuming. In contrast, managers might seek relatively simple guidance, such as insight into when a new potential management action should be considered, and how much effort should be expended on trialing such an action. We constructed a two-time-step scenario where a manager is choosing between two possible management actions. The manager has a total budget that can be split between a learning phase and an implementation phase. We use this scenario to investigate when and how much a manager should invest in learning about the management actions available. The optimal investment in learning can be understood intuitively by accounting for the expected value of sample information, the benefits that accrue during learning, the direct costs of learning, and the opportunity costs of learning. We find that the optimal proportion of the budget to spend on learning is characterized by several critical thresholds that mark a jump from spending a large proportion of the budget on learning to spending nothing. For example, as sampling variance increases, it is optimal to spend a larger proportion of the budget on learning, up to a point: if the sampling variance passes a critical threshold, it is no longer beneficial to invest in learning. Similar thresholds are observed as a function of the total budget and the difference in the expected performance of the two actions. We illustrate how this model can be applied using a case study of choosing between alternative rearing diets for hihi, an endangered New Zealand passerine. Although the model presented is a simplified scenario, we believe it is relevant to many management situations. Managers often have relatively short time horizons for management, and might be reluctant to consider further investment in learning and monitoring beyond collecting data from a single time period.

Two-step adaptive management for choosing between two management actions.

PubMed

Moore, Alana L; Walker, Leila; Runge, Michael C; McDonald-Madden, Eve; McCarthy, Michael A

2017-06-01

Adaptive management is widely advocated to improve environmental management. Derivations of optimal strategies for adaptive management, however, tend to be case specific and time consuming. In contrast, managers might seek relatively simple guidance, such as insight into when a new potential management action should be considered, and how much effort should be expended on trialing such an action. We constructed a two-time-step scenario where a manager is choosing between two possible management actions. The manager has a total budget that can be split between a learning phase and an implementation phase. We use this scenario to investigate when and how much a manager should invest in learning about the management actions available. The optimal investment in learning can be understood intuitively by accounting for the expected value of sample information, the benefits that accrue during learning, the direct costs of learning, and the opportunity costs of learning. We find that the optimal proportion of the budget to spend on learning is characterized by several critical thresholds that mark a jump from spending a large proportion of the budget on learning to spending nothing. For example, as sampling variance increases, it is optimal to spend a larger proportion of the budget on learning, up to a point: if the sampling variance passes a critical threshold, it is no longer beneficial to invest in learning. Similar thresholds are observed as a function of the total budget and the difference in the expected performance of the two actions. We illustrate how this model can be applied using a case study of choosing between alternative rearing diets for hihi, an endangered New Zealand passerine. Although the model presented is a simplified scenario, we believe it is relevant to many management situations. Managers often have relatively short time horizons for management, and might be reluctant to consider further investment in learning and monitoring beyond collecting data from a single time period. © 2017 by the Ecological Society of America.

Antimalarials inhibit hematin crystallization by unique drug–surface site interactions

PubMed Central

Olafson, Katy N.; Nguyen, Tam Q.; Rimer, Jeffrey D.; Vekilov, Peter G.

2017-01-01

In malaria pathophysiology, divergent hypotheses on the inhibition of hematin crystallization posit that drugs act either by the sequestration of soluble hematin or their interaction with crystal surfaces. We use physiologically relevant, time-resolved in situ surface observations and show that quinoline antimalarials inhibit β-hematin crystal surfaces by three distinct modes of action: step pinning, kink blocking, and step bunch induction. Detailed experimental evidence of kink blocking validates classical theory and demonstrates that this mechanism is not the most effective inhibition pathway. Quinolines also form various complexes with soluble hematin, but complexation is insufficient to suppress heme detoxification and is a poor indicator of drug specificity. Collectively, our findings reveal the significance of drug–crystal interactions and open avenues for rationally designing antimalarial compounds. PMID:28559329

Spacecraft crew procedures from paper to computers

NASA Technical Reports Server (NTRS)

Oneal, Michael; Manahan, Meera

1993-01-01

Large volumes of paper are launched with each Space Shuttle Mission that contain step-by-step instructions for various activities that are to be performed by the crew during the mission. These instructions include normal operational procedures and malfunction or contingency procedures and are collectively known as the Flight Data File (FDF). An example of nominal procedures would be those used in the deployment of a satellite from the Space Shuttle; a malfunction procedure would describe actions to be taken if a specific problem developed during the deployment. A new FDF and associated system is being created for Space Station Freedom. The system will be called the Space Station Flight Data File (SFDF). NASA has determined that the SFDF will be computer-based rather than paper-based. Various aspects of the SFDF are discussed.

Timing paradox of stepping and falls in ageing: not so quick and quick(er) on the trigger.

PubMed

Rogers, Mark W; Mille, Marie-Laure

2016-08-15

Physiological and degenerative changes affecting human standing balance are major contributors to falls with ageing. During imbalance, stepping is a powerful protective action for preserving balance that may be voluntarily initiated in recognition of a balance threat, or be induced by an externally imposed mechanical or sensory perturbation. Paradoxically, with ageing and falls, initiation slowing of voluntary stepping is observed together with perturbation-induced steps that are triggered as fast as or faster than for younger adults. While age-associated changes in sensorimotor conduction, central neuronal processing and cognitive functions are linked to delayed voluntary stepping, alterations in the coupling of posture and locomotion may also prolong step triggering. It is less clear, however, how these factors may explain the accelerated triggering of induced stepping. We present a conceptual model that addresses this issue. For voluntary stepping, a disruption in the normal coupling between posture and locomotion may underlie step-triggering delays through suppression of the locomotion network based on an estimation of the evolving mechanical state conditions for stability. During induced stepping, accelerated step initiation may represent an event-triggering process whereby stepping is released according to the occurrence of a perturbation rather than to the specific sensorimotor information reflecting the evolving instability. In this case, errors in the parametric control of induced stepping and its effectiveness in stabilizing balance would be likely to occur. We further suggest that there is a residual adaptive capacity with ageing that could be exploited to improve paradoxical triggering and other changes in protective stepping to impact fall risk. © 2016 The Authors. The Journal of Physiology © 2016 The Physiological Society.

THE CLEAN ENERGY-ENVIRONMENT GUIDE TO ACTION ...

EPA Pesticide Factsheets

The Guide to Action identifies and describes sixteen clean energy policies and strategies that are delivering economic and environmental results for states. For each policy, the Guide describes: Objectives and benefits of the policy; Examples of states that have implemented the policy; Responsibilities of key players at the state level, including typical roles of the main stakeholders; Opportunities to coordinate implementation with other federal and state policies, partnerships and technical assistance resources; Best practices for policy design, implementation, and evaluation, including state examples; Action steps for states to take when adopting or modifying their clean energy policies, based on existing state experiences; Resources for additional information on individual state policies, legislative and regulatory language, and analytical tools and methods. States participating in the Clean Energy-Environment State Partnership Program will use the Guide to Action to: Develop their own Clean Energy-Environment Action Plan that is appropriate to their state; Identify the roles and responsibilities of key decision-makers, such as environmental regulators, state legislatures, public utility commissioners, and state energy offices; Access and apply technical assistance resources, models, and tools available for state-specific analyses and program implementation; and Learn from each other as they develop their own clean energy programs and policies.

Top-Level Players' Visual Control of Interceptive Actions: Bootsma and Van Wieringen (1990) 20 Years Later

ERIC Educational Resources Information Center

Bootsma, Reinoud J.; Fernandez, Laure; Morice, Antoine H. P.; Montagne, Gilles

2010-01-01

Using a two-step approach, Van Soest et al. (2010) recently questioned the pertinence of the conclusions drawn by Bootsma and Van Wieringen (1990) with respect to the visual regulation of an exemplary rapid interceptive action: the attacking forehand drive in table tennis. In the first step, they experimentally compared the movement behaviors of…

An alternative for presenting interactive dynamic data sets in electronic presentations: a scrollable flash movie loop.

PubMed

Yam, Chun-Shan

2007-11-01

The purpose of this article is to describe an alternative for creating scrollable movie loops for electronic presentations including PowerPoint. The alternative provided in this article enables academic radiologists to present scrollable movie loops in PowerPoint. The scrolling capability is created using Flash ActionScript. A Flash template with the required ActionScript code is provided. Users can simply download the template and follow the step-by-step demonstration to create scrollable movie loops. No previous ActionScript programming knowledge is necessary.

Arabidopsis KANADI1 acts as a transcriptional repressor by interacting with a specific cis-element and regulates auxin biosynthesis, transport, and signaling in opposition to HD-ZIPIII factors.

PubMed

Huang, Tengbo; Harrar, Yaël; Lin, Changfa; Reinhart, Brenda; Newell, Nicole R; Talavera-Rauh, Franklin; Hokin, Samuel A; Barton, M Kathryn; Kerstetter, Randall A

2014-01-01

The formation of leaves and other lateral organs in plants depends on the proper specification of adaxial-abaxial (upper-lower) polarity. KANADI1 (KAN1), a member of the GARP family of transcription factors, is a key regulator of abaxial identity, leaf growth, and meristem formation in Arabidopsis thaliana. Here, we demonstrate that the Myb-like domain in KAN1 binds the 6-bp motif GNATA(A/T) and that this motif alone is sufficient to squelch transcription of a linked reporter in vivo. In addition, we report that KAN1 acts as a transcriptional repressor. Among its targets are genes involved in auxin biosynthesis, auxin transport, and auxin response. Furthermore, we find that the adaxializing HD-ZIPIII transcription factor REVOLUTA has opposing effects on multiple components of the auxin pathway. We hypothesize that HD-ZIPIII and KANADI transcription factors pattern auxin accumulation and responsiveness in the embryo. Specifically, we propose the opposing actions of KANADI and HD-ZIPIII factors on cotyledon formation (KANADI represses and HD-ZIPIII promotes cotyledon formation) occur through their opposing actions on genes acting at multiple steps in the auxin pathway.

Climate Action Planning Process | Climate Neutral Research Campuses | NREL

Science.gov Websites

Action Planning Process Climate Action Planning Process For research campuses, NREL has developed a five-step process to develop and implement climate action plans: Determine baseline energy consumption Analyze technology options Prepare a plan and set priorities Implement the climate action plan Measure and

Texas strategic action plan for motorcycles : 2013-2018.

DOT National Transportation Integrated Search

2013-06-01

The Texas Strategic Action Plan for Motorcycles: 2013-2018 provides an integrated : approach to identify implementable strategies and action steps to make the : road environment and infrastructure safer for motorcyclists and other powered : two- and ...

Exemplar-based human action pose correction.

PubMed

Shen, Wei; Deng, Ke; Bai, Xiang; Leyvand, Tommer; Guo, Baining; Tu, Zhuowen

2014-07-01

The launch of Xbox Kinect has built a very successful computer vision product and made a big impact on the gaming industry. This sheds lights onto a wide variety of potential applications related to action recognition. The accurate estimation of human poses from the depth image is universally a critical step. However, existing pose estimation systems exhibit failures when facing severe occlusion. In this paper, we propose an exemplar-based method to learn to correct the initially estimated poses. We learn an inhomogeneous systematic bias by leveraging the exemplar information within a specific human action domain. Furthermore, as an extension, we learn a conditional model by incorporation of pose tags to further increase the accuracy of pose correction. In the experiments, significant improvements on both joint-based skeleton correction and tag prediction are observed over the contemporary approaches, including what is delivered by the current Kinect system. Our experiments for the facial landmark correction also illustrate that our algorithm can improve the accuracy of other detection/estimation systems.

Perception-action coupling and anticipatory performance in baseball batting.

PubMed

Ranganathan, Rajiv; Carlton, Les G

2007-09-01

The authors examined 10 expert and 10 novice baseball batters' ability to distinguish between a fastball and a change-up in a virtual environment. They used 2 different response modes: (a) an uncoupled response in which the batters verbally predicted the type of pitch and (b) a coupled response in which the batters swung a baseball bat to try and hit the virtual ball. The authors manipulated visual information from the pitcher and ball in 6 visual conditions. The batters were more accurate in predicting the type of pitch when the response was uncoupled. In coupled responses, experts were better able to use the first 100 ms of ball flight independently of the pitcher's kinematics. In addition, the skilled batters' stepping patterns were related to the pitcher's kinematics, whereas their swing time was related to ball speed. Those findings suggest that specific task requirements determine whether a highly coupled perception-action environment improves anticipatory performance. The authors also highlight the need for research on interceptive actions to be conducted in the performer's natural environment.

Building false memories without suggestions.

PubMed

Foster, Jeffrey L; Garry, Maryanne

2012-01-01

People can come to remember doing things they have never done. The question we asked in this study is whether people can systematically come to remember performing actions they never really did, in the absence of any suggestion from the experimenter. People built LEGO vehicles, performing some steps but not others. For half the people, all the pieces needed to assemble each vehicle were laid out in order in front of them while they did the building; for the other half, the pieces were hidden from view. The next day, everyone returned for a surprise recognition test. People falsely and confidently remembered having carried out steps they did not; those who saw all the pieces while they built each vehicle were more likely to correctly remember performing steps they did perform but equally likely to falsely remember performing steps they did not. We explain our results using the source monitoring framework: People used the relationships between actions to internally generate the missing, related actions, later mistaking that information for genuine experience.

77 FR 43818 - Applications for New Awards; State-Tribal Education Partnership (STEP) Pilot Grant Competition...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-26

... DEPARTMENT OF EDUCATION Applications for New Awards; State-Tribal Education Partnership (STEP... Secondary Education, Department of Education. ACTION: Notice reopening the STEP Pilot Grant Competition for... STEP Pilot Grant Competition. That notice established a July 13, 2012, deadline for transmittal of...

40 CFR 35.2203 - Step 7 projects.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Step 7 projects. 35.2203 Section 35... STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works § 35.2203 Step 7 projects. (a) Prior to initiating action to acquire real property, a Step 7 grantee shall submit for Regional...

40 CFR 86.523-78 - Oxides of nitrogen analyzer calibration.

Code of Federal Regulations, 2011 CFR

2011-07-01

.... (11) Calculate the efficiency of the NOX converter by substituting the concentrations obtained into... obtained in step (8). b = concentration obtained in step (9). c = concentration obtained in step (6). d = concentration obtained in step (7). If converter efficiency is not greater than 90 percent corrective action...

40 CFR 86.523-78 - Oxides of nitrogen analyzer calibration.

Code of Federal Regulations, 2010 CFR

2010-07-01

.... (11) Calculate the efficiency of the NOX converter by substituting the concentrations obtained into... obtained in step (8). b = concentration obtained in step (9). c = concentration obtained in step (6). d = concentration obtained in step (7). If converter efficiency is not greater than 90 percent corrective action...

Proposed best modeling practices for assessing the effects of ecosystem restoration on fish

USGS Publications Warehouse

Rose, Kenneth A; Sable, Shaye; DeAngelis, Donald L.; Yurek, Simeon; Trexler, Joel C.; Graf, William L.; Reed, Denise J.

2015-01-01

Large-scale aquatic ecosystem restoration is increasing and is often controversial because of the economic costs involved, with the focus of the controversies gravitating to the modeling of fish responses. We present a scheme for best practices in selecting, implementing, interpreting, and reporting of fish modeling designed to assess the effects of restoration actions on fish populations and aquatic food webs. Previous best practice schemes that tended to be more general are summarized, and they form the foundation for our scheme that is specifically tailored for fish and restoration. We then present a 31-step scheme, with supporting text and narrative for each step, which goes from understanding how the results will be used through post-auditing to ensure the approach is used effectively in subsequent applications. We also describe 13 concepts that need to be considered in parallel to these best practice steps. Examples of these concepts include: life cycles and strategies; variability and uncertainty; nonequilibrium theory; biological, temporal, and spatial scaling; explicit versus implicit representation of processes; and model validation. These concepts are often not considered or not explicitly stated and casual treatment of them leads to mis-communication and mis-understandings, which in turn, often underlie the resulting controversies. We illustrate a subset of these steps, and their associated concepts, using the three case studies of Glen Canyon Dam on the Colorado River, the wetlands of coastal Louisiana, and the Everglades. Use of our proposed scheme will require investment of additional time and effort (and dollars) to be done effectively. We argue that such an investment is well worth it and will more than pay back in the long run in effective and efficient restoration actions and likely avoided controversies and legal proceedings.

Retinoic acid biosynthesis catalyzed by retinal dehydrogenases relies on a rate-limiting conformational transition associated with substrate recognition

PubMed Central

Bchini, Raphaël; Vasiliou, Vasilis; Branlant, Guy; Talfournier, François; Rahuel-Clermont, Sophie

2012-01-01

Retinoic acid (RA), a metabolite of vitamin A, exerts pleiotropic effects throughout life in vertebrate organisms. Thus, RA action must be tightly regulated through the coordinated action of biosynthetic and degradating enzymes. The last step of retinoic acid biosynthesis is irreversibly catalyzed by the NAD-dependent retinal dehydrogenases (RALDH), which are members of the aldehyde dehydrogenase (ALDH) superfamily. Low intracellular retinal concentrations imply efficient substrate molecular recognition to ensure high affinity and specificity of RALDHs for retinal. This study addresses the molecular basis of retinal recognition in human ALDH1A1 (or RALDH1) and rat ALDH1A2 (or RALDH2), through the comparison of the catalytic behavior of retinal analogs and use of the fluorescence properties of retinol. We show that, in contrast to long chain unsaturated substrates, the rate-limiting step of retinal oxidation by RALDHs is associated with acylation. Use of the fluorescence resonance energy transfer upon retinol interaction with RALDHs provides evidence that retinal recognition occurs in two steps: binding into the substrate access channel, and a slower structural reorganization with a rate constant of the same magnitude as the kcat for retinal oxidation: 0.18 vs. 0.07 s−1 and 0.25 vs. 0.1 s−1 for ALDH1A1 and ALDH1A2, respectively. This suggests that the conformational transition of the RALDH-retinal complex significantly contributes to the rate-limiting step that controls the kinetics of retinal oxidation, as a prerequisite for the formation of a catalytically competent Michaelis complex. This conclusion is consistent with the general notion that structural flexibility within the active site of ALDH enzymes has been shown to be an integral component of catalysis. PMID:23220587

Assessing Changes in Job Behavior Due to Training: A Guide to the Participant Action Plan Approach.

ERIC Educational Resources Information Center

Office of Personnel Management, Washington, DC.

This guide provides a brief introduction to the Participant Action Plan Approach (PAPA) and a user's handbook. Part I outlines five steps of PAPA which determine how job behavior is changed by training course or program participation. Part II, the manual, is arranged by the five steps of the PAPA approach. Planning for PAPA discusses making…

Implement balanced scorecard to translate strategic plan into actionable objectives.

PubMed

2004-09-01

Faced with challenges ranging from declining reimbursement to staff shortages, health care organizations--integrated delivery systems, physician group practices, disease management providers, and others--increasingly are turning to general business models to map out step-by-step action plans for performance measurement and process improvement. Creating a "balanced scorecard" is an obvious starting point for assessing and improving clinical and financial performance.

Recent developments in the hammerhead ribozyme field.

PubMed Central

Vaish, N K; Kore, A R; Eckstein, F

1998-01-01

Developments in the hammerhead ribozyme field during the last two years are reviewed here. New results on the specificity of this ribozyme, the mechanism of its action and on the question of metal ion involvement in the cleavage reaction are discussed. To demonstrate the potential of ribozyme technology examples of the application of this ribozyme for the inhibition of gene expression in cell culture, in animals, as well as in plant models are presented. Particular emphasis is given to critical steps in the approach, including RNA site selection, delivery, vector development and cassette construction. PMID:9826743

Antimicrobial resistance-a threat to the world's sustainable development.

PubMed

Jasovský, Dušan; Littmann, Jasper; Zorzet, Anna; Cars, Otto

2016-08-01

This commentary examines how specific sustainable development goals (SDGs) are affected by antimicrobial resistance and suggests how the issue can be better integrated into international policy processes. Moving beyond the importance of effective antibiotics for the treatment of acute infections and health care generally, we discuss how antimicrobial resistance also impacts on environmental, social, and economic targets in the SDG framework. The paper stresses the need for greater international collaboration and accountability distribution, and suggests steps towards a broader engagement of countries and United Nations agencies to foster global intersectoral action on antimicrobial resistance.

JEM spotlight: Monitoring the treatment efficiency of a full scale ozonation on a sewage treatment plant with a mode-of-action based test battery.

PubMed

Escher, Beate I; Bramaz, Nadine; Ort, Christoph

2009-10-01

Tertiary treatment of wastewater with ozone is a promising technique for removing residual micropollutants that remain after secondary biological treatment. We monitored the performance of a full-scale ozonation reactor on a sewage treatment plant in Switzerland with a screening battery of bioassays. Six toxicity endpoints were selected that covered non-specific toxicity, as well as selected receptor-mediated modes of action and reactive toxicity. Non-specific toxicity was assessed with two bioassays, the bioluminescence inhibition of the marine luminescent bacterium Vibrio Fischeri and the growth inhibition of the green algae Pseudokirchneriella subcapitata. Treatment efficiency was around 90% for the secondary treatment, but only 65% and 76% for the ozonation step in the two non-specific endpoints, respectively. This finding is consistent with this type of oxidation reaction because ozone only modifies the organic molecules but does not mineralize them fully leaving residual toxicity of the transformation products. In contrast, the specific receptor-mediated endpoints of inhibition of photosystem II in algae and estrogenicity were largely reduced by ozonation. While compounds inhibiting photosynthesis proved to be rather recalcitrant toward biological treatment with only 47% removal, an additional 86% removal by ozonation yielded an overall treatment efficiency in the entire treatment chain of 89%. The effect on estrogenicity, quantified with the yeast estrogen screen, was even more significant: A treatment efficiency of 95% in the secondary treatment, 86% during ozonation plus a small effect by biological sand filtration yielded an overall treatment efficiency of 99.5%. Insecticides that inhibit acetylcholinesterase were fairly resistant to degradation, but an overall treatment efficiency of 91% was achieved in two steps: 72% in biological treatment and 60% during ozonation. Finally, no significant genotoxicity was observed with the umuC test after ozonation, while the influent showed a genotoxic response when it was enriched by a factor of 15 to 60. Treatment efficiency increased with the ozone dose and remained virtually unchanged over ozone doses above 500 g ozone per kg dissolved organic carbon. The reduction of toxicity can be rationalized by the chemical oxidation processes likely to occur for each group of chemicals that are typical for a given mode of toxic action. For comparison, tertiary treatment with powdered activated carbon was also evaluated, which poses a viable alternative to ozonation with respect to removal of micropollutants.

Health inequalities and the health of the poor: what do we know? What can we do?

PubMed Central

Gwatkin, D. R.

2000-01-01

The contents of this theme section of the Bulletin of the World Health Organization on "Inequalities in health" have two objectives: to present the initial findings from a new generation of research that has been undertaken in response to renewed concern for health inequalities; and to stimulate movement for action in order to correct the problems identified by this research. The research findings are presented in the five articles which follow. This Critical Reflection proposes two initial steps for the action needed to alleviate the problem; other suggestions are given by the participants in a Round Table discussion which is published after these articles. The theme section concludes with extracts from the classic writings of the nineteenth-century public health pioneer, William Farr, who is widely credited as one of the founders of the scientific study of health inequalities, together with a commentary. This Critical Reflection contributes to the discussion of the action needed by proposing two initial steps for action. That professionals who give very high priority to the distinct but related objectives of poverty alleviation, inequality reduction, and equity enhancement recognize that their shared concern for the distributional aspects of health policy is far more important than any differences that may divide them. That health policy goals, currently expressed as societal averages, be reformulated so that they point specifically to conditions among the poor and to poor-rich differences. For example, infant mortality rates among the poor or the differences in infant mortality between rich and poor sectors would be more useful indicators than the average infant mortality rates for the whole population. PMID:10686729

Structural Model for the Flip-Flop Action in Thiamin Pyrophosphate-Dependent Human Pyruvate Dehydrogenase

NASA Technical Reports Server (NTRS)

Ciszak, Ewa; Dominiak, Paulina

2003-01-01

The derivative of vitamin B1 thiamin pyrophosphate (TPP) is a cofactor of enzymes performing catalysis in pathways of energy production, including (i) decarboxylation of alpha-keto acids followed by (ii) transketolation. These enzymes have shown a common mechanism of TPP activation by imposing an active V-conformation of this coenzyme that brings the N4 atom of the aminopyrimidine ring to the distance required for the intramolecular C-H N hydrogen-bonding with the C2- atom of the thiazolium ring. The reactive C2 atom of TPP is the nucleophile that attacks the carbonyl carbon of different substrates used by the TPP-dependent enzymes. The structure of the heterotetrameric human pyruvate dehydrogenase (Elp) recently determined in our laboratory (1) revealed the association pattern of the subunits and the specifics of two chemically equivalent cofactor binding sites. Dynamic nonequivalence of these two cofactor sites directs the flip-flop action of this enzyme, depending upon which two active sites effect each other (2). The crystal structure derived from the holo-form of Elp provided the basis for the model of the flip-flop action of Elp in which different steps of the catalytic reaction are performed in each of the two cofactor sites at any given moment, where these steps are governed by the concerted shuttle-like motion of the subunits. It is further proposed that balancing a hydrogen-bond network and related cofactor geometry determine the continuity of catalytic events.

Planning-in-Action: An Innovative Approach to Human Development. The Hunger Project.

ERIC Educational Resources Information Center

Community Development Journal, 1991

1991-01-01

The Hunger Project in India used a strategic planning-in-action approach that involved (1) reaching a common understanding; (2) creating a strategic intent; (3) choosing social indicators; (4) identifying strategic objectives; (5) empowering leadership; (6) identifying immediate action steps; and (7) sustaining the action. (SK)

Instruction manual for U.S. Geological Survey sediment observers

USGS Publications Warehouse

Johnson, Gary P.

1997-01-01

This instruction manual is intended for use by U.S. Geological Survey (USGS) Sediment Observers. An overview of the USGS Sediment Program is presented, and basic theory on sediment transport is explained. Step-by-step instructions on when and how to sample for sediment also are presented. USGS Sediment Observer safety issues are discussed and corrective actions are presented. An empty pouch is included at the back of the manual for miscellaneous supplies, such as extra sampler nozzles, thermometers, new gaskets, and markers to be supplied by USGS personnel distributing the manual. A plastic reference card also is included, which can be removed from the manual and kept at the sampling site. Only general guidelines are presented in the manual so space is provided for USGS personnel distributing the manual to fill in project specific instructions.

Effectiveness of a stepped primary care smoking cessation intervention (ISTAPS study): design of a cluster randomised trial.

PubMed

Cabezas, Carmen; Martin, Carlos; Granollers, Silvia; Morera, Concepció; Ballve, Josep Lluis; Zarza, Elvira; Blade, Jordi; Borras, Margarida; Serra, Antoni; Puente, Diana

2009-02-04

There is a considerable body of evidence on the effectiveness of specific interventions in individuals who wish to quit smoking. However, there are no large-scale studies testing the whole range of interventions currently recommended for helping people to give up smoking; specifically those interventions that include motivational interviews for individuals who are not interested in quitting smoking in the immediate to short term. Furthermore, many of the published studies were undertaken in specialized units or by a small group of motivated primary care centres. The objective of the study is to evaluate the effectiveness of a stepped smoking cessation intervention based on a trans-theoretical model of change, applied to an extensive group of Primary Care Centres (PCC). Cluster randomised clinical trial. Unit of randomization: basic unit of care consisting of a family physician and a nurse, both of whom care for the same population (aprox. 2000 people). Intention to treat analysis. Smokers (n = 3024) aged 14 to 75 years consulting for any reason to PCC and who provided written informed consent to participate in the trial. 6-month implementation of recommendations of a Clinical Practice Guideline which includes brief motivational interviews for smokers at the precontemplation - contemplation stage, brief intervention for smokers in preparation-action who do not want help, intensive intervention with pharmacotherapy for smokers in preparation-action who want help, and reinforcing intervention in the maintenance stage. usual care. Self-reported abstinence confirmed by exhaled air carbon monoxide concentration of

40 CFR 35.2202 - Step 2+3 projects.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Step 2+3 projects. 35.2202 Section 35... STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works § 35.2202 Step 2+3 projects. (a) Prior to initiating action to acquire eligible real property, a Step 2+3 grantee shall submit for...

29 CFR 1952.372 - Completion of developmental steps and certification.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 9 2010-07-01 2010-07-01 false Completion of developmental steps and certification. 1952... § 1952.372 Completion of developmental steps and certification. (a) In accordance with 29 CFR 1952.373(b.... This action is judged to have sufficiently fulfilled the commitments of this step. (b) In accordance...

Plan to combat extensively drug-resistant tuberculosis: recommendations of the Federal Tuberculosis Task Force.

PubMed

2009-02-13

An estimated one third of the world's population is infected with Mycobacterium tuberculosis, and nearly 9 million persons develop disease caused by M. tuberculosis each year. Although tuberculosis (TB) occurs predominantly in resource-limited countries, it also occurs in the United States. During 1985-1992, the United States was confronted with an unprecedented TB resurgence. This resurgence was accompanied by a rise in multidrug-resistant TB (MDR TB), which is defined as TB that is resistant to the two most effective first-line therapeutic drugs, isoniazid and rifampin. In addition, virtually untreatable strains of M. tuberculosis are emerging globally. Extensively drug-resistant (XDR) TB is defined as MDR TB that also is resistant to the most effective second-line therapeutic drugs used commonly to treat MDR TB: fluoroquinolones and at least one of three injectable second-line drugs used to treat TB (amikacin, kanamycin, or capreomycin). XDR TB has been identified in all regions of the world, including the United States. In the United States, the cost of hospitalization for one XDR TB patient is estimated to average $483,000, approximately twice the cost for MDR TB patients. Because of the limited responsiveness of XDR TB to available antibiotics, mortality rates among patients with XDR TB are similar to those of TB patients in the preantibiotic era. In January 1992, CDC convened a Federal TB Task Force to draft an action plan to improve prevention and control of drug-resistant TB in the United States (CDC. National action plan to combat multidrug-resistant tuberculosis. MMWR 1992;41([No. RR-11]). In November 2006, CDC reconvened the Task Force to draft an updated action plan to address the issue of MDR TB and XDR TB. Task Force members were divided into nine response areas and charged with articulating the most pressing problems, identifying barriers to improvement, and recommending specific action steps to improve prevention and control of XDR TB within their respective areas. Although the first priority of the Federal TB Task Force convened in 2006 was to delineate objectives and action steps to address MDR TB and XDR TB domestically, members recognized the necessity for TB experts in the United States to work with the international community to help strengthen TB control efforts globally. TB represents a substantial public health problem in low- and middle-income countries, many of which might benefit from assistance by the United States. In addition, the global TB epidemic directly affects the United States because the majority of all cases of TB and 80% of cases of MDR TB reported in the United States occur among foreign-born persons. For these reasons, the Action Plan also outlines potential steps that U.S. government agencies can take to help solve global XDR TB problems. Unless the fundamental causes of MDR TB and XDR TB are addressed in the United States and internationally, the United States is likely to experience a growing number of cases of MDR TB and XDR TB that will be difficult, if not impossible, to treat or prevent. The recommendations provided in this report include specific action steps and new activities that will require additional funding and a renewed commitment by government and nongovernment organizations involved in domestic and international TB control efforts to be implemented effectively. The Federal TB Task Force will coordinate activities of various federal agencies and partner with state and local health departments, nonprofit and TB advocacy organizations in implementing this plan to control and prevent XDR TB in the United States and to contribute to global efforts in the fight against this emerging public health crisis.

Habits as action sequences: hierarchical action control and changes in outcome value

PubMed Central

Dezfouli, Amir; Lingawi, Nura W.; Balleine, Bernard W.

2014-01-01

Goal-directed action involves making high-level choices that are implemented using previously acquired action sequences to attain desired goals. Such a hierarchical schema is necessary for goal-directed actions to be scalable to real-life situations, but results in decision-making that is less flexible than when action sequences are unfolded and the decision-maker deliberates step-by-step over the outcome of each individual action. In particular, from this perspective, the offline revaluation of any outcomes that fall within action sequence boundaries will be invisible to the high-level planner resulting in decisions that are insensitive to such changes. Here, within the context of a two-stage decision-making task, we demonstrate that this property can explain the emergence of habits. Next, we show how this hierarchical account explains the insensitivity of over-trained actions to changes in outcome value. Finally, we provide new data that show that, under extended extinction conditions, habitual behaviour can revert to goal-directed control, presumably as a consequence of decomposing action sequences into single actions. This hierarchical view suggests that the development of action sequences and the insensitivity of actions to changes in outcome value are essentially two sides of the same coin, explaining why these two aspects of automatic behaviour involve a shared neural structure. PMID:25267824

Method for treating wastewater using microorganisms and vascular aquatic plants

NASA Technical Reports Server (NTRS)

Wolverton, B. C. (Inventor)

1983-01-01

A method for treating wastewater compresses subjecting the wastewater to an anaerobic setting step for at least 6 hours and passing the liquid effluent from the anaerobic settling step through a filter cell in an upflow manner. There the effluent is subjected first to the action of anaerobic and facultative microorganisms, and then to the action of aerobic microorganisms and the roots of at least one vascular aquatic plant.

Infants Prospectively Control Reaching Based on the Difficulty of Future Actions: To What Extent Can Infants' Multiple-Step Actions Be Explained by Fitts' Law?

ERIC Educational Resources Information Center

Gottwald, Janna M.; De Bortoli Vizioli, Aurora; Lindskog, Marcus; Nyström, Pär; L. Ekberg, Therese; von Hofsten, Claes; Gredebäck, Gustaf

2017-01-01

Prospective motor control, a key element of action planning, is the ability to adjust one's actions with respect to task demands and action goals in an anticipatory manner. The current study investigates whether 14-month-olds can prospectively control their reaching actions based on the difficulty of the subsequent action. We used a reach-to-place…

Action Research: Its Origins and Early Application.

ERIC Educational Resources Information Center

Cook, Stuart W.

This paper contains informal remarks on action research in social psychology from its post World War II origins to its current status. Kurt Lewin first described action research in the 1946 article, "Action Research and Minority Problems," as a three-step process of program planning, program execution, and follow-up evaluation. Ronald Lippitt and…

Evaluation of accuracy in implant site preparation performed in single- or multi-step drilling procedures.

PubMed

Marheineke, Nadine; Scherer, Uta; Rücker, Martin; von See, Constantin; Rahlf, Björn; Gellrich, Nils-Claudius; Stoetzer, Marcus

2018-06-01

Dental implant failure and insufficient osseointegration are proven results of mechanical and thermal damage during the surgery process. We herein performed a comparative study of a less invasive single-step drilling preparation protocol and a conventional multiple drilling sequence. Accuracy of drilling holes was precisely analyzed and the influence of different levels of expertise of the handlers and additional use of drill template guidance was evaluated. Six experimental groups, deployed in an osseous study model, were representing template-guided and freehanded drilling actions in a stepwise drilling procedure in comparison to a single-drill protocol. Each experimental condition was studied by the drilling actions of respectively three persons without surgical knowledge as well as three highly experienced oral surgeons. Drilling actions were performed and diameters were recorded with a precision measuring instrument. Less experienced operators were able to significantly increase the drilling accuracy using a guiding template, especially when multi-step preparations are performed. Improved accuracy without template guidance was observed when experienced operators were executing single-step versus multi-step technique. Single-step drilling protocols have shown to produce more accurate results than multi-step procedures. The outcome of any protocol can be further improved by use of guiding templates. Operator experience can be a contributing factor. Single-step preparations are less invasive and are promoting osseointegration. Even highly experienced surgeons are achieving higher levels of accuracy by combining this technique with template guidance. Hereby template guidance enables a reduction of hands-on time and side effects during surgery and lead to a more predictable clinical diameter.

What experimental experience affects dogs' comprehension of human communicative actions?

PubMed

Hauser, Marc D; Comins, Jordan A; Pytka, Lisa M; Cahill, Donal P; Velez-Calderon, Sofia

2011-01-01

Studies of dogs report that individuals reliably respond to the goal-directed communicative actions (e.g., pointing) of human experimenters. All of these studies use some version of a multi-trial approach, thereby allowing for the possibility of rapid learning within an experimental session. The experiments reported here ask whether dogs can respond correctly to a communicative action based on only a single presentation, thereby eliminating the possibility of learning within the experimental context. We tested 173 dogs. For each dog reaching our test criteria, we used a single presentation of six different goal-directed actions within a session, asking whether they correctly follow to a target goal (container with concealed food) a (1) distal hand point, (2) step toward one container, (3) hand point to one container followed by step toward the other, (4) step toward one container and point to the other, (5) distal foot point with the experimenter's hands free, and (6) distal foot point with the experimenter's hands occupied. Given only a single presentation, dogs selected the correct container when the experimenter hand pointed, foot pointed with hands occupied, or stepped closer to the target container, but failed on the other actions, despite using the same method. The fact that dogs correctly followed foot pointing with hands occupied, but not hands free, suggests that they are sensitive to environmental constraints, and use this information to infer rational, goal-directed action. We discuss these results in light of the role of experience in recognizing communicative gestures, as well as the significance of coding criteria for studies of canine competence. Copyright © 2010 Elsevier B.V. All rights reserved.

What goes on behind closed doors: physiological vs. pharmacological steroid hormone actions

PubMed Central

Simons, S. Stoney

2009-01-01

Summary Steroid hormone-activated receptor proteins are among the best understood class of factors for altering gene transcription in cells. Steroid receptors are of major importance in maintaining normal human physiology by responding to circulating concentrations of steroid in the nM range. Nonetheless, most studies of steroid receptor action have been conducted using the supra-physiological conditions of saturating concentrations (≥100 nM) of potent synthetic steroid agonists. Here we summarize the recent developments arising from experiments using two clinically relevant conditions: subsaturating concentrations of agonist (to mimic the circulating concentrations in mammals) and saturating concentrations of antagonists (which are employed in endocrine therapies to block the actions of endogenous steroids). These studies have revealed new facets of steroid hormone action that could not be uncovered by conventional experiments with saturating concentrations of agonist steroids, such as a plethora of factors/conditions for the differential control of gene expression by physiological levels of steroid, a rational approach for examining the gene-specific variations in partial agonist activity of antisteroids, and a dissociation of steroid potency and efficacy that implies the existence of separate, and possibly novel, mechanistic steps and cofactors. PMID:18623071

76 FR 10082 - Office of International Trade; State Trade and Export Promotion (STEP) Grant Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-23

... (STEP) Grant Program AGENCY: U.S. Small Business Administration (SBA). ACTION: Notice of grant... Program Announcement No. OIT-STEP-2011- 01 to invite the States, the District of Columbia and the U.S. Territories to apply for a STEP grant to carry out export promotion programs that assist eligible small...

Use of a Nutrition Behavior Change Counseling Tool: Lessons from a Rapid Qualitative Assessment in Eastern Zambia

PubMed Central

Weiss, Ingrid; Stepanovic, Serena; Chinyemba, Ulembe; Bateman, Jessica; Hemminger, Carolyn; Burrows, Emily

2016-01-01

The U.S. Agency for International Development Feed the Future Mawa Project – led by Catholic Relief Services – aims to improve food and economic security for farming households in Zambia’s Eastern Province. Mawa employs social and behavior change (SBC) strategies with households and communities to improve nutrition and reduce stunting among children under two (CU2). To support these strategies, sub-partner University Research Co., LLC employed a participatory process to develop a series of 35 action cards, each illustrating one project-promoted behavior, that are used at household and community group levels. Caregivers of CU2 are given a full set of action cards to promote household dialogue and support for the promoted behaviors. As a final step in the action card tool development process, a qualitative rapid assessment was conducted 1 month after implementation to investigate preliminary ways action cards were being used, and if the methods of using the cards had the potential to impact behavior change. The research team conducted nine key informant interviews and four focus group discussions with Mawa staff and administered 41 qualitative interview questionnaires with project participants in the Chipata and Lundazi districts. Although not based on a representative sampling frame, the assessment produced valuable results for program improvement purposes. It also provided a feedback mechanism for community-based staff and project participants, a crucial step in the participatory tool development process. The assessment found that Mawa staff at every level use action cards combined with at least one other social behavior change tool for each nutrition intervention. Our results suggest that Mawa staff and project participants share a common understanding of the cards’ purpose. Each group noted that the cards provide a visual cue for action and reinforce previous Mawa nutrition messages. Intended uses confirmed by the assessment include encouraging household cooperation, negotiating behavior change, telling stories, and integrating messages with other project sectors. Based on the findings, recommendations for future project activities include aligning efforts against a theory of change to optimize use of all SBC tools; leveraging action card use to strengthen cross-sectoral integration within Mawa; and specific ongoing monitoring of action card use to improve activity implementation. PMID:27630980

A Neural Dynamic Model Generates Descriptions of Object-Oriented Actions.

PubMed

Richter, Mathis; Lins, Jonas; Schöner, Gregor

2017-01-01

Describing actions entails that relations between objects are discovered. A pervasively neural account of this process requires that fundamental problems are solved: the neural pointer problem, the binding problem, and the problem of generating discrete processing steps from time-continuous neural processes. We present a prototypical solution to these problems in a neural dynamic model that comprises dynamic neural fields holding representations close to sensorimotor surfaces as well as dynamic neural nodes holding discrete, language-like representations. Making the connection between these two types of representations enables the model to describe actions as well as to perceptually ground movement phrases-all based on real visual input. We demonstrate how the dynamic neural processes autonomously generate the processing steps required to describe or ground object-oriented actions. By solving the fundamental problems of neural pointing, binding, and emergent discrete processing, the model may be a first but critical step toward a systematic neural processing account of higher cognition. Copyright © 2017 The Authors. Topics in Cognitive Science published by Wiley Periodicals, Inc. on behalf of Cognitive Science Society.

Achieving School Readiness: A 5-Year Action Agenda for Maryland. Presented to the Subcabinet for Children, Youth and Families by the Leadership in Action Program.

ERIC Educational Resources Information Center

Maryland State Dept. of Education, Baltimore.

As a result of lengthy deliberations and review of evidence-based proven practices by the Leadership in Action Program in Maryland, this action agenda details 6 goals, 25 strategies, and 106 action steps determined as most critical to ensuring that all of Maryland's children will enter school ready to learn. The action agenda was submitted to the…

Enabling Energy Saving Innovations Act

THOMAS, 112th Congress

Rep. Aderholt, Robert B. [R-AL-4

2012-04-26

Senate - 09/24/2012 Message on Senate action sent to the House. (All Actions) Notes: For further action, see H.R.6582, which became Public Law 112-210 on 12/18/2012. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Temporary Surface Transportation Extension Act of 2012

THOMAS, 112th Congress

Rep. Mica, John L. [R-FL-7

2012-06-28

06/29/2012 For Further Action See H.R.6064. (All Actions) Notes: For further action, see H.R.6064, which became Public Law 112-140 on 6/29/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Emergency preparedness of families of children with developmental disabilities: What public health and safety emergency planners need to know

PubMed Central

Wolf-Fordham, Susan; Curtin, Carol; Maslin, Melissa; Bandini, Linda; Hamad, Charles D.

2015-01-01

Objective To assess the emergency preparedness knowledge, behaviors, and training needs of families of children with developmental disabilities (DD). Design An online survey. Participants A sample of 314 self-selecting US parents/guardians of children with DD, aged birth-21 years. Main outcome measures 1) Preparedness self-assessment; 2) self-report regarding the extent to which families followed 11 specific preparedness action steps derived from publicly available preparedness guides; and 3) parent training and support needs. Results Although most participants assessed themselves to be somewhat to moderately well prepared, even those who reported being “very well prepared” had taken fewer than half of 11 recommended action steps. Most participants expressed a need for preparedness support; virtually all the respondents felt that training was either important or very important. Conclusions Children with disabilities are known to be particularly vulnerable to negative disaster impacts. Overall, parents in this study appeared under-prepared to meet family disaster needs, although they recognized its importance. The results suggest opportunities and methods for public health and safety planning, education and outreach to parents of children with DD who would benefit from targeted training such as information and skill building to develop effective family preparedness plans and connections to local emergency management and responders. PMID:25779895

American Samoa: Energy Action Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ness, J. Erik; Haase, Scott; Conrad, Misty

2016-09-01

This document outlines actions being taken to reduce American Samoa's petroleum consumption. It describes the four near-term strategies selected by the American Samoa Renewable Energy Committee during action-planning workshops conducted in May 2016, and describes the steps that will need to be taken to implement those strategies.

Kingman and Heritage Islands Act of 2009

THOMAS, 111th Congress

Rep. Norton, Eleanor Holmes [D-DC-At Large

2009-04-23

Senate - 09/28/2010 Message on Senate action sent to the House. (All Actions) Notes: For further action, see H.R.6278, which became Public Law 111-328 on 12/22/2010. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Reducing Flight Delays Act of 2013

THOMAS, 113th Congress

Sen. Collins, Susan M. [R-ME

2013-04-25

Senate - 04/30/2013 Message on Senate action sent to the House. (All Actions) Notes: For further action, see H.R.1765, which became Public Law 113-9 on 5/1/2013. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Temporary Bankruptcy Judgeships Extension Act of 2011

THOMAS, 112th Congress

Rep. Smith, Lamar [R-TX-21

2011-03-10

Senate - 04/23/2012 Message on Senate action sent to the House. (All Actions) Notes: For further action, see H.R.4967, which became Public Law 112-121 on 5/25/2012. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

15 CFR 8b.6 - Remedial action, voluntary action, and self-evaluation.

Code of Federal Regulations, 2013 CFR

2013-01-01

... PROHIBITION OF DISCRIMINATION AGAINST THE HANDICAPPED IN FEDERALLY ASSISTED PROGRAMS OPERATED BY THE... handicapped individuals, appropriate remedial steps to eliminate the effects of any discrimination that... of handicap in violation of section 504 or this part, the recipient shall take such remedial action...

15 CFR 8b.6 - Remedial action, voluntary action, and self-evaluation.

Code of Federal Regulations, 2010 CFR

2010-01-01

... PROHIBITION OF DISCRIMINATION AGAINST THE HANDICAPPED IN FEDERALLY ASSISTED PROGRAMS OPERATED BY THE... handicapped individuals, appropriate remedial steps to eliminate the effects of any discrimination that... of handicap in violation of section 504 or this part, the recipient shall take such remedial action...

15 CFR 8b.6 - Remedial action, voluntary action, and self-evaluation.

Code of Federal Regulations, 2011 CFR

2011-01-01

... PROHIBITION OF DISCRIMINATION AGAINST THE HANDICAPPED IN FEDERALLY ASSISTED PROGRAMS OPERATED BY THE... handicapped individuals, appropriate remedial steps to eliminate the effects of any discrimination that... of handicap in violation of section 504 or this part, the recipient shall take such remedial action...

15 CFR 8b.6 - Remedial action, voluntary action, and self-evaluation.

Code of Federal Regulations, 2014 CFR

2014-01-01

... PROHIBITION OF DISCRIMINATION AGAINST THE HANDICAPPED IN FEDERALLY ASSISTED PROGRAMS OPERATED BY THE... handicapped individuals, appropriate remedial steps to eliminate the effects of any discrimination that... of handicap in violation of section 504 or this part, the recipient shall take such remedial action...

15 CFR 8b.6 - Remedial action, voluntary action, and self-evaluation.

Code of Federal Regulations, 2012 CFR

2012-01-01

... PROHIBITION OF DISCRIMINATION AGAINST THE HANDICAPPED IN FEDERALLY ASSISTED PROGRAMS OPERATED BY THE... handicapped individuals, appropriate remedial steps to eliminate the effects of any discrimination that... of handicap in violation of section 504 or this part, the recipient shall take such remedial action...

Middle School STEP Act

THOMAS, 113th Congress

Sen. Kaine, Tim [D-VA

2014-09-10

Senate - 09/10/2014 Read twice and referred to the Committee on Health, Education, Labor, and Pensions. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Next Steps for Credit Availability Act

THOMAS, 112th Congress

Rep. Velazquez, Nydia M. [D-NY-12

2012-06-08

House - 07/11/2012 Referred to the Subcommittee on Capital Markets and Government Sponsored Enterprises. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

75 FR 29359 - Draft Environmental Impact Statement for the Tamiami Trail Modifications: Next Steps Project...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-25

... Tamiami Trail Modifications: Next Steps Project, Everglades National Park Tamiami Trail Modifications... Interior. ACTION: Notice of availability of the Draft Environmental Impact Statement for the Tamiami Trail... Statement (DEIS) for the Tamiami Trail (U.S. Highway 41) Modifications: Next Steps Project for Everglades...

VisAdapt: A Visualization Tool to Support Climate Change Adaptation.

PubMed

Johansson, Jimmy; Opach, Tomasz; Glaas, Erik; Neset, Tina-Simone; Navarra, Carlo; Linner, Bjorn-Ola; Rod, Jan Ketil

2017-01-01

The web-based visualization VisAdapt tool was developed to help laypeople in the Nordic countries assess how anticipated climate change will impact their homes. The tool guides users through a three-step visual process that helps them explore risks and identify adaptive actions specifically modified to their location and house type. This article walks through the tool's multistep, user-centered design process. Although VisAdapt's target end users are Nordic homeowners, the insights gained from the development process and the lessons learned from the project are applicable to a wide range of domains.

On being a successful clinician educator: Lessons learned to share with new practitioners.

PubMed

Huggins, Charnicia E

2017-05-01

This article discusses lessons learned by a pharmacy clinician-educator during the early stage of her career in academia. In particular, the importance of establishing good mentoring relationships is highlighted as is the need for flexibility, board certification, publications, and loyalty to one's institution. The purpose of this article is to provide new clinician-educators with specific action steps - i.e. principles for success, to combine with self-motivation in order to promote longevity in academia and a sense of personal fulfillment and accomplishment. Copyright © 2017 Elsevier Inc. All rights reserved.

Antimicrobial resistance—a threat to the world’s sustainable development

PubMed Central

Jasovský, Dušan; Littmann, Jasper; Zorzet, Anna; Cars, Otto

2016-01-01

This commentary examines how specific sustainable development goals (SDGs) are affected by antimicrobial resistance and suggests how the issue can be better integrated into international policy processes. Moving beyond the importance of effective antibiotics for the treatment of acute infections and health care generally, we discuss how antimicrobial resistance also impacts on environmental, social, and economic targets in the SDG framework. The paper stresses the need for greater international collaboration and accountability distribution, and suggests steps towards a broader engagement of countries and United Nations agencies to foster global intersectoral action on antimicrobial resistance. PMID:27416324

Teaching critical health literacy in the US as a means to action on the social determinants of health

PubMed Central

Mogford, Elizabeth; Gould, Linn; DeVoght, Andra

2011-01-01

In spite of improvements in global health over the 20th century, health inequities are increasing. Mounting evidence suggests that reducing health inequities requires taking action on the social determinants of health (SDOH), which include income, education, employment, political empowerment and other factors. This paper introduces an alternative health education curriculum, developed by the US-based non-profit organization Just Health Action, which teaches critical health literacy as a step towards empowering people to achieve health equity. Critical health literacy is defined as an individual's understanding of the SDOH combined with the skills to take action at both the individual and the community level. Prior to describing our curricular framework, we connect the recommendations of the World Health Organization Commission on the SDOH with the objectives of the Ottawa Charter for Health Promotion by arguing that achieving them is reliant on critical health literacy. Then we describe our four-part curricular framework for teaching critical health literacy. Part 1, Knowledge, focuses on teaching the SDOH and the paradigm of health as a human right. Part 2, Compass, refers to activities that help students find their own direction as a social change agent. Part 3, Skills, refers to teaching specific advocacy tools and strategies. Part 4, Action, refers to the development and implementation of an action intended to increase health equity by addressing the SDOH. We describe activities that we use to motivate, engage and empower students to take action on the SDOH and provide examples of advocacy skills students have learned and actions they have implemented. PMID:20729240

Validation, Proof-of-Concept, and Postaudit of the Groundwater Flow and Transport Model of the Project Shoal Area

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ahmed Hassan

2004-09-01

The groundwater flow and radionuclide transport model characterizing the Shoal underground nuclear test has been accepted by the State of Nevada Division of Environmental Protection. According to the Federal Facility Agreement and Consent Order (FFACO) between DOE and the State of Nevada, the next steps in the closure process for the site are then model validation (or postaudit), the proof-of-concept, and the long-term monitoring stage. This report addresses the development of the validation strategy for the Shoal model, needed for preparing the subsurface Corrective Action Decision Document-Corrective Action Plan and the development of the proof-of-concept tools needed during the five-yearmore » monitoring/validation period. The approach builds on a previous model, but is adapted and modified to the site-specific conditions and challenges of the Shoal site.« less

Assessing potential targets of calcium action in light-modulated gravitropism

NASA Technical Reports Server (NTRS)

Roux, S. J.

1995-01-01

Light, through the mediation of the pigment phytochrome, modulates the gravitropic response of the shoots and roots of many plants. The transduction of both light and gravity stimuli appears to involve Ca(2+)-regulated steps, one or more of which may represent points of intersection between the two transduction chains. To be confident that Ca2+ plays a critical role in stimulus-response coupling for gravitropism, it will be important to identify specific targets of Ca2+ action whose function can be clearly linked to the regulation of growth. Calcium typically exerts its influence on cell metabolism through binding to and activating key regulatory proteins. The three best characterized of these proteins in plants are the calmodulins, calcium-dependent protein kinases, and annexins. In this review we summarize what is known about the structure and function of these proteins and speculate on how their activation by Ca2+ could influence the differential growth response of gravitropism.

Implementation science and the pregnancy risk assessment monitoring system.

PubMed

Grigorescu, Violanda I; D'Angelo, Denise V; Harrison, Leslie L; Taraporewalla, Aspy J; Shulman, Holly; Smith, Ruben A

2014-12-01

This paper describes the restructuring of the Pregnancy Risk Assessment Monitoring System (PRAMS), a surveillance system of the Centers for Disease Control and Prevention (CDC)'s Division of Reproductive Health conducted for 25 years in collaboration with state and city health departments. With the ultimate goal to better inform health care providers, public health programs, and policy, changes were made to various aspects of PRAMS to enhance its capacity on assessing and monitoring public health interventions and clinical practices in addition to risk behaviors, disease prevalence, comorbidities, and service utilization. Specifically, the three key PRAMS changes identified as necessary and described in this paper are questionnaire revision, launching the web-based centralized PRAMS Integrated Data Collection System, and enhancing the access to PRAMS data through the web query system known as Centers for Disease Control and Prevention's PRAMS Online Data for Epidemiologic Research/PRAMStat. The seven action steps of Knowledge To Action cycle, an illustration of the implementation science process, that reflect the milestones necessary in bridging the knowledge-to-action gap were used as framework for each of these key changes.

Taking Responsible Action for Community Safety Act

THOMAS, 111th Congress

Rep. Bean, Melissa L. [D-IL-8

2009-07-30

House - 07/31/2009 Referred to the Subcommittee on Railroads, Pipelines, and Hazardous Materials. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Taking Responsible Action for Community Safety Act

THOMAS, 112th Congress

Rep. Biggert, Judy [R-IL-13

2011-01-05

House - 01/06/2011 Referred to the Subcommittee on Railroads, Pipelines, and Hazardous Materials. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

To prohibit certain actions with respect to deferred action for aliens not lawfully present in the United States, and for other purposes.

THOMAS, 113th Congress

Rep. Blackburn, Marsha [R-TN-7

2014-07-30

Senate - 09/08/2014 Read the second time. Placed on Senate Legislative Calendar under General Orders. Calendar No. 551. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

Affirmative Action Employment Plan. Revised.

ERIC Educational Resources Information Center

Oakland Unified School District, CA.

This is the affirmative action employment plan adopted by the Board of Education of the Oakland Unified School District, Oakland, California. A statement of school district policy and goals is provided. Responsibilities of the school district administrators and the Affirmative Action Advisory Committee are also outlined. Steps to be taken to…

STEP UP for American Small Businesses Act

THOMAS, 113th Congress

Sen. Cantwell, Maria [D-WA

2014-12-09

Senate - 12/09/2014 Read twice and referred to the Committee on Small Business and Entrepreneurship. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Local Foods, Local Places Toolkit

EPA Pesticide Factsheets

Toolkit to help communities that want to use local foods to spur revitalization. The toolkit gives step-by-step instructions to help communities plan and host a workshop and create an action plan to implement.

Caltech campus executive LDRD.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shepodd, Timothy J.; Knudsen, Tamara

2013-01-01

The environment most brain systems of humans and other animals are almost constantly confronted with is complex and continuously changing, with each time step updating a potentially bewildering set of opportunities and demands for action. Far from the controlled, discrete trials used in most neuro- and psychological investigations, behavior outside the lab at Caltech is a seamless and continuous process of monitoring (and error correction) of ongoing action, and of evaluating persistence in the current activity with respect to opportunities to switch tasks as alternatives become available. Prior work on frontopolar and prefrontal task switching, use tasks within the samemore » modality (View a stream of symbols on a screen and perform certain response mappings depending on task rules). However, in these task switches the effector is constant: only the mapping of visual symbols to the specific button changes. In this task, the subjects are choosing what kinds of future action decisions they want to perform, where they can control either which body part will act, or which direction they will orient an instructed body action. An effector choice task presents a single target and the subject selects which effector to use to reach the target (eye or hand). While the techniques available for humans can be less spatially resolved compared to non-human primate neural data, they do allow for experimentation on multiple brain areas with relative ease. Thus, we address a broader network of areas involved in motor decisions. We aim to resolve a current dispute regarding the specific functional roles of brain areas that are often co-activated in studies of decision tasks, dorsal premotor cortex(PMd) and posterior parietal cortex(PPC). In one model, the PPC distinctly drives intentions for action selection, whereas PMd stimulation results in complex multi-joint movements without any awareness of, nor subjective feeling of, willing the elicited movement, thus seems to merely help execute the chosen action.« less

Steps Toward Effective Production of Speech (STEPS): No. 6--Rewards and How to Use Them.

ERIC Educational Resources Information Center

Sheeley, Eugene C.; McQuiddy, Doris

This guide, part of a series of booklets for parents of deaf-blind children developed by Project STEP (Steps Toward Effective Production of Speech), considers the use of rewards in shaping or changing the behavior of deaf-blind children. The types of rewards (e.g., food, drink, touch, action, something to listen to or look at) and selection of…

Using a Spectral Method to Evaluate Hyporheic Exchange and its Effect on Reach Scale Nitrate Removal.

NASA Astrophysics Data System (ADS)

Moren, I.; Worman, A. L. E.; Riml, J.

2017-12-01

Previous studies have shown that hyporheic exchange processes can be of great importance for the transport, retention and mass removal of nutrients in streams. Specifically, the flow of surface water through the hyporheic zone enhances redox-sensitive reactions such as coupled nitrification-denitrification. This self-cleaning capacity of streams can be utilized in stream restoration projects aiming to improve water quality by reconstructing the geomorphology of the streams. To optimize the effect of restoration actions we need quantitative understanding of the linkage between stream geomorphology, hyporheic exchange processes and the desired water quality targets. Here we propose an analytical, spectral methodology to evaluate how different stream geomorphologies induce hyporheic exchange on a wide range of spatial and temporal scales. Measurements of streambed topographies and surface water profiles from agricultural streams were used to calculate the average hyporheic exchange velocity and residence times and the result was compared with in-stream tracer test. Furthermore, the hyporheic exchange induced by steps in the surface water profile was derived as a comparison of the theoretical capacity of the system. Based on differences in hyporheic exchange, the mass removal of nitrate could be derived for the different geomorphologies. The maximum nitrate mass removal was found to be related to a specific Damkhöler number, which reflects that the mass removal can be either reaction or transport controlled. Therefore, although hyporheic exchange induced by steps in the surface water profile was generally larger than the hyporheic exchange in the observed natural reaches, this would not necessarily lead a larger nitrate mass removal provided that the hyporheic residence times are not long enough to facilitate denitrification processes. The study illustrates the importance to investigate a stream thoroughly before any remediation actions are implemented, specifically to evaluate if the mass removal is reaction or transport controlled.

PREEMIE Reauthorization Act

THOMAS, 112th Congress

Sen. Alexander, Lamar [R-TN

2011-07-28

Senate - 12/19/2012 Message on House action received in Senate and at desk: House amendments to Senate bill. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

[From complexity to simplification: contribution of the EPM Research Unit to producing a toolkit for risk assessment and management of biomechanical overload and WMSDs prevention].

PubMed

Occhipinti, E; Colombini, Daniela

2011-01-01

When studying musculoskeletal disorders and their connection with working conditions (WMSDs), several factors of different nature (mechanical, organizational, psychophysical, individual) and their interrelationship have been considered important in general models for epidemiologic surveys and risk assessment and management. Hence the necessity of a "holistic" (that is to say complex, global, multifactorial and interdisciplinary) approach to MSD prevention, especially when establishing technical norms, guidelines and strategic plans of action at national or international level. On the other hand, considering the widespread presence of these factors and WMSDs in many working contexts, there is a great demand by OSH agencies and operators to develop "simple" tools for risk assessment and management, usable also by non-experts in both developed and developing countries. Both these needs are perfectly justified but are also to a certain extent in conflict. How can we address the problem, i.e., simplify complexity? METHODS AND CRITERIA: The proposals are based on two essential criteria: 1) Act on a step-by-step approach using basic tools first and more complex tools only when necessary. 2) Take into account the complexity and the presence of multiple influencing factors at every step (even if with different degrees of in-depth analysis). The proposals are mainly developed within the framework of an IEA-WHO collaboration initiative for a "Toolkit for MSD prevention" but they are also derived from other converging issues (i.e. ISO application document of LSO series 11228 on manual handling). The proposals consider: 1) A Basic Step devoted to preliminary occupational hazard identification and priority check by operative "key enter" questions (at this step all potential hazards--including those influencing WMSDs--should be considered). This step also can be carried out by non-experts with limited training. 2) First Step, focused on WMSDs risk factors, consisting of a "quick assessment" and mainly addressed to identifying 3 possible conditions: acceptable/no consequences; high risk present/redesign urgently needed; a more detailed analysis (via tools proposed in second step) is necessary. This step can also be carried out by non-experts with only limited training. 3) Second Step, where recognized tools (i.e. from international standards or guidelines) for risk (of WMSDs) estimation are used as a consequence of the first step outcome. Examples of such tools are "adaptations" of the Revised NIOSH Lifting Equation, Liberty Mutual Psychophysical Tables, OCRA Checklist, etc. These tools should be able to adequately take account of most of the influencing factors. For some particular working sectors (i.e. agriculture) these tools need to be specifically adapted. For particular working sectors a database could be envisaged where the most common tasks (with their "variants") are "intrinsically" evaluated by experts and could provide non-experts with the relevant knowledge to be applied to the specific work context. This step can be carried out only by persons with some sort of specific training.

Resume Development.

ERIC Educational Resources Information Center

Lorenzen, Elizabeth A.; And Others

This paper presents a step-by-step guide for developing a resume as part of a job search campaign. The paper presents the following information: purposes of the resume; steps in resume development; resume formats; resume headings; and some "do's and some "don't's." The paper also includes a list of 161 action verbs for use in resume development, a…

Lights, Camera, Action: Facilitating the Design and Production of Effective Instructional Videos

ERIC Educational Resources Information Center

Di Paolo, Terry; Wakefield, Jenny S.; Mills, Leila A.; Baker, Laura

2017-01-01

This paper outlines a rudimentary process intended to guide faculty in K-12 and higher education through the steps involved to produce video for their classes. The process comprises four steps: planning, development, delivery and reflection. Each step is infused with instructional design information intended to support the collaboration between…

Next Step for Main Street Credit Availability Act of 2009

THOMAS, 111th Congress

Sen. Snowe, Olympia J. [R-ME

2009-08-06

Senate - 08/06/2009 Read twice and referred to the Committee on Small Business and Entrepreneurship. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Sequential protein association with nascent 60S ribosomal particles.

PubMed

Saveanu, Cosmin; Namane, Abdelkader; Gleizes, Pierre-Emmanuel; Lebreton, Alice; Rousselle, Jean-Claude; Noaillac-Depeyre, Jacqueline; Gas, Nicole; Jacquier, Alain; Fromont-Racine, Micheline

2003-07-01

Ribosome biogenesis in eukaryotes depends on the coordinated action of ribosomal and nonribosomal proteins that guide the assembly of preribosomal particles. These intermediate particles follow a maturation pathway in which important changes in their protein composition occur. The mechanisms involved in the coordinated assembly of the ribosomal particles are poorly understood. We show here that the association of preribosomal factors with pre-60S complexes depends on the presence of earlier factors, a phenomenon essential for ribosome biogenesis. The analysis of the composition of purified preribosomal complexes blocked in maturation at specific steps allowed us to propose a model of sequential protein association with, and dissociation from, early pre-60S complexes for several preribosomal factors such as Mak11, Ssf1, Rlp24, Nog1, and Nog2. The presence of either Ssf1 or Nog2 in complexes that contain the 27SB pre-rRNA defines novel, distinct pre-60S particles that contain the same pre-rRNA intermediates and that differ only by the presence or absence of specific proteins. Physical and functional interactions between Rlp24 and Nog1 revealed that the assembly steps are, at least in part, mediated by direct protein-protein interactions.

Design and validation of a wind tunnel system for odour sampling on liquid area sources.

PubMed

Capelli, L; Sironi, S; Del Rosso, R; Céntola, P

2009-01-01

The aim of this study is to describe the methods adopted for the design and the experimental validation of a wind tunnel, a sampling system suitable for the collection of gaseous samples on passive area sources, which allows to simulate wind action on the surface to be monitored. The first step of the work was the study of the air velocity profiles. The second step of the work consisted in the validation of the sampling system. For this purpose, the odour concentration of some air samples collected by means of the wind tunnel was measured by dynamic olfactometry. The results of the air velocity measurements show that the wind tunnel design features enabled the achievement of a uniform and homogeneous air flow through the hood. Moreover, the laboratory tests showed a very good correspondence between the odour concentration values measured at the wind tunnel outlet and the odour concentration values predicted by the application of a specific volatilization model, based on the Prandtl boundary layer theory. The agreement between experimental and theoretical trends demonstrate that the studied wind tunnel represents a suitable sampling system for the simulation of specific odour emission rates from liquid area sources without outward flow.

Strengthening of accountability systems to create healthy food environments and reduce global obesity.

PubMed

Swinburn, Boyd; Kraak, Vivica; Rutter, Harry; Vandevijvere, Stefanie; Lobstein, Tim; Sacks, Gary; Gomes, Fabio; Marsh, Tim; Magnusson, Roger

2015-06-20

To achieve WHO's target to halt the rise in obesity and diabetes, dramatic actions are needed to improve the healthiness of food environments. Substantial debate surrounds who is responsible for delivering effective actions and what, specifically, these actions should entail. Arguments are often reduced to a debate between individual and collective responsibilities, and between hard regulatory or fiscal interventions and soft voluntary, education-based approaches. Genuine progress lies beyond the impasse of these entrenched dichotomies. We argue for a strengthening of accountability systems across all actors to substantially improve performance on obesity reduction. In view of the industry opposition and government reluctance to regulate for healthier food environments, quasiregulatory approaches might achieve progress. A four step accountability framework (take the account, share the account, hold to account, and respond to the account) is proposed. The framework identifies multiple levers for change, including quasiregulatory and other approaches that involve government-specified and government-monitored progress of private sector performance, government procurement mechanisms, improved transparency, monitoring of actions, and management of conflicts of interest. Strengthened accountability systems would support government leadership and stewardship, constrain the influence of private sector actors with major conflicts of interest on public policy development, and reinforce the engagement of civil society in creating demand for healthy food environments and in monitoring progress towards obesity action objectives. Copyright © 2015 Elsevier Ltd. All rights reserved.

Action recognition in depth video from RGB perspective: A knowledge transfer manner

NASA Astrophysics Data System (ADS)

Chen, Jun; Xiao, Yang; Cao, Zhiguo; Fang, Zhiwen

2018-03-01

Different video modal for human action recognition has becoming a highly promising trend in the video analysis. In this paper, we propose a method for human action recognition from RGB video to Depth video using domain adaptation, where we use learned feature from RGB videos to do action recognition for depth videos. More specifically, we make three steps for solving this problem in this paper. First, different from image, video is more complex as it has both spatial and temporal information, in order to better encode this information, dynamic image method is used to represent each RGB or Depth video to one image, based on this, most methods for extracting feature in image can be used in video. Secondly, as video can be represented as image, so standard CNN model can be used for training and testing for videos, beside, CNN model can be also used for feature extracting as its powerful feature expressing ability. Thirdly, as RGB videos and Depth videos are belong to two different domains, in order to make two different feature domains has more similarity, domain adaptation is firstly used for solving this problem between RGB and Depth video, based on this, the learned feature from RGB video model can be directly used for Depth video classification. We evaluate the proposed method on one complex RGB-D action dataset (NTU RGB-D), and our method can have more than 2% accuracy improvement using domain adaptation from RGB to Depth action recognition.

SPAR-H Step-by-Step Guidance

DOE Office of Scientific and Technical Information (OSTI.GOV)

W. J. Galyean; A. M. Whaley; D. L. Kelly

This guide provides step-by-step guidance on the use of the SPAR-H method for quantifying Human Failure Events (HFEs). This guide is intended to be used with the worksheets provided in: 'The SPAR-H Human Reliability Analysis Method,' NUREG/CR-6883, dated August 2005. Each step in the process of producing a Human Error Probability (HEP) is discussed. These steps are: Step-1, Categorizing the HFE as Diagnosis and/or Action; Step-2, Rate the Performance Shaping Factors; Step-3, Calculate PSF-Modified HEP; Step-4, Accounting for Dependence, and; Step-5, Minimum Value Cutoff. The discussions on dependence are extensive and include an appendix that describes insights obtained from themore » psychology literature.« less

Quantum robots and environments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Benioff, P.

1998-08-01

Quantum robots and their interactions with environments of quantum systems are described, and their study justified. A quantum robot is a mobile quantum system that includes an on-board quantum computer and needed ancillary systems. Quantum robots carry out tasks whose goals include specified changes in the state of the environment, or carrying out measurements on the environment. Each task is a sequence of alternating computation and action phases. Computation phase activites include determination of the action to be carried out in the next phase, and recording of information on neighborhood environmental system states. Action phase activities include motion of themore » quantum robot and changes in the neighborhood environment system states. Models of quantum robots and their interactions with environments are described using discrete space and time. A unitary step operator T that gives the single time step dynamics is associated with each task. T=T{sub a}+T{sub c} is a sum of action phase and computation phase step operators. Conditions that T{sub a} and T{sub c} should satisfy are given along with a description of the evolution as a sum over paths of completed phase input and output states. A simple example of a task{emdash}carrying out a measurement on a very simple environment{emdash}is analyzed in detail. A decision tree for the task is presented and discussed in terms of the sums over phase paths. It is seen that no definite times or durations are associated with the phase steps in the tree, and that the tree describes the successive phase steps in each path in the sum over phase paths. {copyright} {ital 1998} {ital The American Physical Society}« less

Modeling Search Behaviors during the Acquisition of Expertise in a Sequential Decision-Making Task.

PubMed

Moënne-Loccoz, Cristóbal; Vergara, Rodrigo C; López, Vladimir; Mery, Domingo; Cosmelli, Diego

2017-01-01

Our daily interaction with the world is plagued of situations in which we develop expertise through self-motivated repetition of the same task. In many of these interactions, and especially when dealing with computer and machine interfaces, we must deal with sequences of decisions and actions. For instance, when drawing cash from an ATM machine, choices are presented in a step-by-step fashion and a specific sequence of choices must be performed in order to produce the expected outcome. But, as we become experts in the use of such interfaces, is it possible to identify specific search and learning strategies? And if so, can we use this information to predict future actions? In addition to better understanding the cognitive processes underlying sequential decision making, this could allow building adaptive interfaces that can facilitate interaction at different moments of the learning curve. Here we tackle the question of modeling sequential decision-making behavior in a simple human-computer interface that instantiates a 4-level binary decision tree (BDT) task. We record behavioral data from voluntary participants while they attempt to solve the task. Using a Hidden Markov Model-based approach that capitalizes on the hierarchical structure of behavior, we then model their performance during the interaction. Our results show that partitioning the problem space into a small set of hierarchically related stereotyped strategies can potentially capture a host of individual decision making policies. This allows us to follow how participants learn and develop expertise in the use of the interface. Moreover, using a Mixture of Experts based on these stereotyped strategies, the model is able to predict the behavior of participants that master the task.

Weapons Acquisition System Reform Through Enhancing Technical Knowledge and Oversight Act of 2009

THOMAS, 111th Congress

Rep. Skelton, Ike [D-MO-4

2009-04-27

House - 05/13/2009 Laid on the table. See S.454 for further action. (All Actions) Notes: For further action, see S.454, which became Public Law 111-23 on 5/22/2009. Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

Training Subversives: The Ethics of Leadership Preparation

ERIC Educational Resources Information Center

Buskey, Frederick C.; Pitts, Eric M.

2009-01-01

School leaders have traditionally learned to "do no harm." But they must also develop the necessary skills to "do good." That can require "artistic subordination," a theory of action inspired by nonviolent protests. School leaders can learn five steps to that will help guide their actions in sticky situations. Strategies for action are framed in…

Whistleblower Protection Enhancement Act of 2010

THOMAS, 111th Congress

Sen. Akaka, Daniel K. [D-HI

2009-02-03

Senate - 12/22/2010 Message on House action received in Senate and at desk: House amendments to Senate bill. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

Students Taking Action for Road Safety Act of 2010

THOMAS, 111th Congress

Sen. Klobuchar, Amy [D-MN

2010-07-30

Senate - 07/30/2010 Read twice and referred to the Committee on Commerce, Science, and Transportation. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

CDC Vital Signs: Hospital Actions Affect Breastfeeding

MedlinePlus

... Read the MMWR Science Clips Hospital Actions Affect Breastfeeding Language: English (US) Español (Spanish) Recommend on Facebook ... in many US hospitals do not fully support breastfeeding. Some of the Ten Steps on which hospitals ...

Faster Action Safety Team Emergency Response Act of 2010

THOMAS, 111th Congress

Sen. Casey, Robert P., Jr. [D-PA

2010-11-18

Senate - 11/18/2010 Read twice and referred to the Committee on Health, Education, Labor, and Pensions. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Faster Action Safety Team Emergency Response Act of 2011

THOMAS, 112th Congress

Sen. Casey, Robert P., Jr. [D-PA

2011-03-15

Senate - 03/15/2011 Read twice and referred to the Committee on Health, Education, Labor, and Pensions. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Assessing potentially dangerous medical actions with the computer-based case simulation portion of the USMLE step 3 examination.

PubMed

Harik, Polina; Cuddy, Monica M; O'Donovan, Seosaimhin; Murray, Constance T; Swanson, David B; Clauser, Brian E

2009-10-01

The 2000 Institute of Medicine report on patient safety brought renewed attention to the issue of preventable medical errors, and subsequently specialty boards and the National Board of Medical Examiners were encouraged to play a role in setting expectations around safety education. This paper examines potentially dangerous actions taken by examinees during the portion of the United States Medical Licensing Examination Step 3 that is particularly well suited to evaluating lapses in physician decision making, the Computer-based Case Simulation (CCS). Descriptive statistics and a general linear modeling approach were used to analyze dangerous actions ordered by 25,283 examinees that completed CCS for the first time between November 2006 and January 2008. More than 20% of examinees ordered at least one dangerous action with the potential to cause significant patient harm. The propensity to order dangerous actions may vary across clinical cases. The CCS format may provide a means of collecting important information about patient-care situations in which examinees may be more likely to commit dangerous actions and the propensity of examinees to order dangerous tests and treatments.

Wrestling with 'doubt-sayers': a first step in leading community-wide climate change action for better health.

PubMed

Ritchie, Jan

2011-12-01

Although the evidence base for climate change is indisputable and the potential human health impact is extremely concerning, to date public health professionals are playing little part in influencing community change to accept and act on the science. In reviewing the techniques used to obstruct action on tobacco control by vested interests through constantly raising doubt about the science in this arena, a similar pattern is seen in obstructing action on climate change. It is clear that the raising of unverified doubt is the primary tool employed by profit-driven corporations to prevent constructive action in both these arenas, with the very high potential for the health of the whole population to suffer as a result. Those promoting the health of Australians have a responsibility to optimise health in this regard and need to think differently through embracing complexity science and then take action, with the first step being to provide constant counter-arguments to the unsubstantiated statements of the 'doubt-sayers'.

Image editing with Adobe Photoshop 6.0.

PubMed

Caruso, Ronald D; Postel, Gregory C

2002-01-01

The authors introduce Photoshop 6.0 for radiologists and demonstrate basic techniques of editing gray-scale cross-sectional images intended for publication and for incorporation into computerized presentations. For basic editing of gray-scale cross-sectional images, the Tools palette and the History/Actions palette pair should be displayed. The History palette may be used to undo a step or series of steps. The Actions palette is a menu of user-defined macros that save time by automating an action or series of actions. Converting an image to 8-bit gray scale is the first editing function. Cropping is the next action. Both decrease file size. Use of the smallest file size necessary for the purpose at hand is recommended. Final file size for gray-scale cross-sectional neuroradiologic images (8-bit, single-layer TIFF [tagged image file format] at 300 pixels per inch) intended for publication varies from about 700 Kbytes to 3 Mbytes. Final file size for incorporation into computerized presentations is about 10-100 Kbytes (8-bit, single-layer, gray-scale, high-quality JPEG [Joint Photographic Experts Group]), depending on source and intended use. Editing and annotating images before they are inserted into presentation software is highly recommended, both for convenience and flexibility. Radiologists should find that image editing can be carried out very rapidly once the basic steps are learned and automated. Copyright RSNA, 2002

Gait biomechanics of skipping are substantially different than those of running.

PubMed

McDonnell, Jessica; Willson, John D; Zwetsloot, Kevin A; Houmard, Joseph; DeVita, Paul

2017-11-07

The inherit injury risk associated with high-impact exercises calls for alternative ways to achieve the benefits of aerobic exercise while minimizing excessive stresses to body tissues. Skipping presents such an alternative, incorporating double support, flight, and single support phases. We used ground reaction forces (GRFs), lower extremity joint torques and powers to compare skipping and running in 20 healthy adults. The two consecutive skipping steps on each limb differed significantly from each other, and from running. Running had the longest step length, the highest peak vertical GRF, peak knee extensor torque, and peak knee negative and positive power and negative and positive work. Skipping had the greater cadence, peak horizontal GRF, peak hip and ankle extensor torques, peak ankle negative power and work, and peak ankle positive power. The second vs first skipping step had the shorter step length, higher cadence, peak horizontal GRF, peak ankle extensor torque, and peak ankle negative power, negative work, and positive power and positive work. The first skipping step utilized predominately net negative joint work (eccentric muscle action) while the second utilized predominately net positive joint work (concentric muscle action). The skipping data further highlight the persistence of net negative work performed at the knee and net positive work performed at the ankle across locomotion gaits. Evidence of step segregation was seen in distribution of the braking and propelling impulses and net work produced across the hip, knee, and ankle joints. Skipping was substantially different than running and was temporally and spatially asymmetrical with successive foot falls partitioned into a dominant function, either braking or propelling whereas running had a single, repeated step in which both braking and propelling actions were performed equally. Copyright © 2017 Elsevier Ltd. All rights reserved.

Report: EPA Data Standards Plan Completed But Additional Steps Are Needed

EPA Pesticide Factsheets

Report #12-P-0519, June 5, 2012. The actions taken by EPA were either incomplete or lacked steps to help management determine the overall effectiveness of the Agency’s implementation of data standards.

Closing the brain-to-brain loop in laboratory testing.

PubMed

Plebani, Mario; Lippi, Giuseppe

2011-07-01

Abstract The delivery of laboratory services has been described 40 years ago and defined with the foremost concept of "brain-to-brain turnaround time loop". This concept consists of several processes, including the final step which is the action undertaken on the patient based on laboratory information. Unfortunately, the need for systematic feedback to improve the value of laboratory services has been poorly understood and, even more risky, poorly applied in daily laboratory practice. Currently, major problems arise from the unavailability of consensually accepted quality specifications for the extra-analytical phase of laboratory testing. This, in turn, does not allow clinical laboratories to calculate a budget for the "patient-related total error". The definition and use of the term "total error" refers only to the analytical phase, and should be better defined as "total analytical error" to avoid any confusion and misinterpretation. According to the hierarchical approach to classify strategies to set analytical quality specifications, the "assessment of the effect of analytical performance on specific clinical decision-making" is comprehensively at the top and therefore should be applied as much as possible to address analytical efforts towards effective goals. In addition, an increasing number of laboratories worldwide are adopting risk management strategies such as FMEA, FRACAS, LEAN and Six Sigma since these techniques allow the identification of the most critical steps in the total testing process, and to reduce the patient-related risk of error. As a matter of fact, an increasing number of laboratory professionals recognize the importance of understanding and monitoring any step in the total testing process, including the appropriateness of the test request as well as the appropriate interpretation and utilization of test results.

Key Elements of Observing Practice: A Data Wise DVD and Facilitator's Guide

ERIC Educational Resources Information Center

Boudett, Kathryn Parker; City, Elizabeth A.; Russell, Marcia K.

2010-01-01

Based on the bestselling book "Data Wise: A Step-by-Step Guide to Using Assessment Results to Improve Teaching and Learning", and its companion volume, "Data Wise in Action", this DVD and Facilitator's Guide offer insight into one of the most challenging steps in capturing data about school performance: observing and analyzing instructional…

Private Right of Action Against Theft of Trade Secrets Act of 2013

THOMAS, 113th Congress

Rep. Lofgren, Zoe [D-CA-19

2013-06-20

House - 07/15/2013 Referred to the Subcommittee on Crime, Terrorism, Homeland Security, and Investigations. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Terrorism Risk Insurance Program Reauthorization Act of 2014

THOMAS, 113th Congress

Sen. Schumer, Charles E. [D-NY

2014-04-10

Senate - 12/11/2014 Message on House action received in Senate and at desk: House amendment to Senate bill. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

Federal Financial Assistance Management Improvement Act of 2009

THOMAS, 111th Congress

Sen. Voinovich, George V. [R-OH

2009-01-22

Senate - 12/15/2009 Message on House action received in Senate and at desk: House amendment to Senate bill. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

Effect of pyrimido[1,6-a]benzimidazoles, quinolones, and Ca2+ on the DNA gyrase-mediated cleavage reaction.

PubMed Central

Gmünder, H; Kuratli, K; Keck, W

1995-01-01

The quinolones inhibit the A subunit of DNA gyrase in the presence of Mg2+ by interrupting the DNA breakage and resealing steps, and the latter step is also retarded without quinolones if Mg2+ is replaced by Ca2+. Pyrimido[1,6-a]benzimidazoles have been found to represent a new class of potent DNA gyrase inhibitors which also act at the A subunit. To determine alterations in the DNA sequence specificity of DNA gyrase for cleavage sites in the presence of inhibitors of both classes or in the presence of Ca2+, we used DNA restriction fragments of 164, 85, and 71 bp from the pBR322 plasmid as model substrates. Each contained, at a different position, the 20-bp pBR322 sequence around position 990, where DNA gyrase preferentially cleaves in the presence of quinolones. Our results show that pyrimido[1,6-a]benzimidazoles have a mode of action similar to that of quinolones; they inhibit the resealing step and influence the DNA sequence specificity of DNA gyrase in the same way. Differences between inhibitors of both classes could be observed only in the preferences of DNA gyrase for these cleavage sites. The 20-bp sequence appeared to have some properties that induced DNA gyrase to cleave all three DNA fragments in the presence of inhibitors within this sequence, whereas cleavage in the presence of Ca2+ was in addition dependent on the length of the DNA fragments. PMID:7695300

Validity of the Stages of Change in Steps instrument (SoC-Step) for achieving the physical activity goal of 10,000 steps per day.

PubMed

Rosenkranz, Richard R; Duncan, Mitch J; Caperchione, Cristina M; Kolt, Gregory S; Vandelanotte, Corneel; Maeder, Anthony J; Savage, Trevor N; Mummery, W Kerry

2015-11-30

Physical activity (PA) offers numerous benefits to health and well-being, but most adults are not sufficiently physically active to afford such benefits. The 10,000 steps campaign has been a popular and effective approach to promote PA. The Transtheoretical Model posits that individuals have varying levels of readiness for health behavior change, known as Stages of Change (Precontemplation, Contemplation, Preparation, Action, and Maintenance). Few validated assessment instruments are available for determining Stages of Change in relation to the PA goal of 10,000 steps per day. The purpose of this study was to assess the criterion-related validity of the SoC-Step, a brief 10,000 steps per day Stages of Change instrument. Participants were 504 Australian adults (176 males, 328 females, mean age = 50.8 ± 13.0 years) from the baseline sample of the Walk 2.0 randomized controlled trial. Measures included 7-day accelerometry (Actigraph GT3X), height, weight, and self-reported intention, self-efficacy, and SoC-Step: Stages of Change relative to achieving 10,000 steps per day. Kruskal-Wallis H tests with pairwise comparisons were used to determine whether participants differed by stage, according to steps per day, general health, body mass index, intention, and self-efficacy to achieve 10,000 steps per day. Binary logistic regression was used to test the hypothesis that participants in Maintenance or Action stages would have greater likelihood of meeting the 10,000 steps goal, in comparison to participants in the other three stages. Consistent with study hypotheses, participants in Precontemplation had significantly lower intention scores than those in Contemplation (p = 0.003) or Preparation (p < 0.001). Participants in Action or Maintenance stages were more likely to achieve ≥10,000 steps per day (OR = 3.11; 95 % CI = 1.66,5.83) compared to those in Precontemplation, Contemplation, or Preparation. Intention (p < 0.001) and self-efficacy (p < 0.001) to achieve 10,000 steps daily differed by stage, and participants in the Maintenance stage had higher general health status and lower body mass index than those in Precontemplation, Contemplation and Preparation stages (p < 0.05). This brief SoC-Step instrument appears to have good criterion-related validity for determining Stages of Change related to the public health goal of 10,000 steps per day. Australian New Zealand Clinical Trials Registry reference: ACTRN12611000157976 World Health Organization Universal Trial Number: U111-1119-1755.

Effectiveness of a stepped primary care smoking cessation intervention (ISTAPS study): design of a cluster randomised trial

PubMed Central

Cabezas, Carmen; Martin, Carlos; Granollers, Silvia; Morera, Concepció; Ballve, Josep Lluis; Zarza, Elvira; Blade, Jordi; Borras, Margarida; Serra, Antoni; Puente, Diana

2009-01-01

Background There is a considerable body of evidence on the effectiveness of specific interventions in individuals who wish to quit smoking. However, there are no large-scale studies testing the whole range of interventions currently recommended for helping people to give up smoking; specifically those interventions that include motivational interviews for individuals who are not interested in quitting smoking in the immediate to short term. Furthermore, many of the published studies were undertaken in specialized units or by a small group of motivated primary care centres. The objective of the study is to evaluate the effectiveness of a stepped smoking cessation intervention based on a trans-theoretical model of change, applied to an extensive group of Primary Care Centres (PCC). Methods/Design Cluster randomised clinical trial. Unit of randomization: basic unit of care consisting of a family physician and a nurse, both of whom care for the same population (aprox. 2000 people). Intention to treat analysis. Study population: Smokers (n = 3024) aged 14 to 75 years consulting for any reason to PCC and who provided written informed consent to participate in the trial. Intervention: 6-month implementation of recommendations of a Clinical Practice Guideline which includes brief motivational interviews for smokers at the precontemplation – contemplation stage, brief intervention for smokers in preparation-action who do not want help, intensive intervention with pharmacotherapy for smokers in preparation-action who want help, and reinforcing intervention in the maintenance stage. Control group: usual care. Outcome measures: Self-reported abstinence confirmed by exhaled air carbon monoxide concentration of ≤ 10 parts per million. Points of assessment: end of intervention period and 1 and 2 years post-intervention; continuous abstinence rate for 1 year; change in smoking cessation stage; health status measured by SF-36. Discussion The application of a stepped intervention based on the stages of a change model is possible under real and diverse clinical practice conditions, and improves the smoking cessation success rate in smokers, besides of their intention or not to give up smoking at baseline. Trial Registration Clinical Trials.gov Identifier: NCT00125905 PMID:19193233

44 CFR 9.13 - Particular types of temporary housing.

Code of Federal Regulations, 2010 CFR

2010-10-01

...-rise areas. (5) FEMA shall comply with Step 2 Early Public Notice (§ 9.8(c)) and Step 7 Final Public... to flooding, a rejection of a non-floodplain location alternative and of the no-action alternative...

Approving the renewal of import restrictions contained in the Burmese Freedom and Democracy Act of 2003.

THOMAS, 112th Congress

Rep. Crowley, Joseph [D-NY-7

2011-05-26

Senate - 09/15/2011 Message on Senate action sent to the House. (All Actions) Notes: For further action, see H.R.2017, which became Public Law 112-33 on 9/30/2011. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

To designate the United States courthouse under construction at 98 West First Street, Yuma, Arizona, as the "John M. Roll United States Courthouse".

THOMAS, 112th Congress

Rep. Grijalva, Raul M. [D-AZ-7

2011-02-09

02/10/2011 For Further Action See S.188. (All Actions) Notes: For further action, see S.188, which became Public Law 112-2 on 2/17/2011. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Five Steps for Structuring Data-Informed Conversations and Action in Education. REL 2013-001

ERIC Educational Resources Information Center

Kekahio, Wendy; Baker, Myriam

2013-01-01

Using data strategically to guide decisions and actions can have a positive effect on education practices and processes. This facilitation guide shows education data teams how to move beyond simply reporting data to applying data to direct strategic action. Using guiding questions, suggested activities, and activity forms, this guide provides…

Online Actions with Offline Impact: How Online Social Networks Influence Online and Offline User Behavior.

PubMed

Althoff, Tim; Jindal, Pranav; Leskovec, Jure

2017-02-01

Many of today's most widely used computing applications utilize social networking features and allow users to connect, follow each other, share content, and comment on others' posts. However, despite the widespread adoption of these features, there is little understanding of the consequences that social networking has on user retention, engagement, and online as well as offline behavior. Here, we study how social networks influence user behavior in a physical activity tracking application. We analyze 791 million online and offline actions of 6 million users over the course of 5 years, and show that social networking leads to a significant increase in users' online as well as offline activities. Specifically, we establish a causal effect of how social networks influence user behavior. We show that the creation of new social connections increases user online in-application activity by 30%, user retention by 17%, and user offline real-world physical activity by 7% (about 400 steps per day). By exploiting a natural experiment we distinguish the effect of social influence of new social connections from the simultaneous increase in user's motivation to use the app and take more steps. We show that social influence accounts for 55% of the observed changes in user behavior, while the remaining 45% can be explained by the user's increased motivation to use the app. Further, we show that subsequent, individual edge formations in the social network lead to significant increases in daily steps. These effects diminish with each additional edge and vary based on edge attributes and user demographics. Finally, we utilize these insights to develop a model that accurately predicts which users will be most influenced by the creation of new social network connections.

Online Actions with Offline Impact: How Online Social Networks Influence Online and Offline User Behavior

PubMed Central

Althoff, Tim; Jindal, Pranav; Leskovec, Jure

2017-01-01

Many of today’s most widely used computing applications utilize social networking features and allow users to connect, follow each other, share content, and comment on others’ posts. However, despite the widespread adoption of these features, there is little understanding of the consequences that social networking has on user retention, engagement, and online as well as offline behavior. Here, we study how social networks influence user behavior in a physical activity tracking application. We analyze 791 million online and offline actions of 6 million users over the course of 5 years, and show that social networking leads to a significant increase in users’ online as well as offline activities. Specifically, we establish a causal effect of how social networks influence user behavior. We show that the creation of new social connections increases user online in-application activity by 30%, user retention by 17%, and user offline real-world physical activity by 7% (about 400 steps per day). By exploiting a natural experiment we distinguish the effect of social influence of new social connections from the simultaneous increase in user’s motivation to use the app and take more steps. We show that social influence accounts for 55% of the observed changes in user behavior, while the remaining 45% can be explained by the user’s increased motivation to use the app. Further, we show that subsequent, individual edge formations in the social network lead to significant increases in daily steps. These effects diminish with each additional edge and vary based on edge attributes and user demographics. Finally, we utilize these insights to develop a model that accurately predicts which users will be most influenced by the creation of new social network connections. PMID:28345078

Blueprint for action: steps toward a high-quality, high-value maternity care system.

PubMed

Angood, Peter B; Armstrong, Elizabeth Mitchell; Ashton, Diane; Burstin, Helen; Corry, Maureen P; Delbanco, Suzanne F; Fildes, Barbara; Fox, Daniel M; Gluck, Paul A; Gullo, Sue Leavitt; Howes, Joanne; Jolivet, R Rima; Laube, Douglas W; Lynne, Donna; Main, Elliott; Markus, Anne Rossier; Mayberry, Linda; Mitchell, Lynn V; Ness, Debra L; Nuzum, Rachel; Quinlan, Jeffrey D; Sakala, Carol; Salganicoff, Alina

2010-01-01

Childbirth Connection hosted a 90th Anniversary national policy symposium, Transforming Maternity Care: A High Value Proposition, on April 3, 2009, in Washington, DC. Over 100 leaders from across the range of stakeholder perspectives were actively engaged in the symposium work to improve the quality and value of U.S. maternity care through broad system improvement. A multi-disciplinary symposium steering committee guided the strategy from its inception and contributed to every phase of the project. The "Blueprint for Action: Steps Toward a High Quality, High Value Maternity Care System", issued by the Transforming Maternity Care Symposium Steering Committee, answers the fundamental question, "Who needs to do what, to, for, and with whom to improve the quality of maternity care over the next five years?" Five stakeholder workgroups collaborated to propose actionable strategies in 11 critical focus areas for moving expeditiously toward the realization of the long term "2020 Vision for a High Quality, High Value Maternity Care System", also published in this issue. Following the symposium these workgroup reports and recommendations were synthesized into the current blueprint. For each critical focus area, the "Blueprint for Action" presents a brief problem statement, a set of system goals for improvement in that area, and major recommendations with proposed action steps to achieve them. This process created a clear sightline to action that if enacted could improve the structure, process, experiences of care, and outcomes of the maternity care system in ways that when anchored in the culture can indeed transform maternity care. Copyright 2010 Jacobs Institute of Women

Continuous Energy Improvement in Motor Driven Systems - A Guidebook for Industry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gilbert A. McCoy and John G. Douglass

2014-02-01

This guidebook provides a step-by-step approach to developing a motor system energy-improvement action plan. An action plan includes which motors should be repaired or replaced with higher efficiency models, recommendations on maintaining a spares inventory, and discussion of improvements in maintenance practices. The guidebook is the successor to DOE’s 1997 Energy Management for Motor Driven Systems. It builds on its predecessor publication by including topics such as power transmission systems and matching driven equipment to process requirements in addition to motors.

The STARTEC Decision Support Tool for Better Tradeoffs between Food Safety, Quality, Nutrition, and Costs in Production of Advanced Ready-to-Eat Foods.

PubMed

Skjerdal, Taran; Gefferth, Andras; Spajic, Miroslav; Estanga, Edurne Gaston; de Cecare, Alessandra; Vitali, Silvia; Pasquali, Frederique; Bovo, Federica; Manfreda, Gerardo; Mancusi, Rocco; Trevisiani, Marcello; Tessema, Girum Tadesse; Fagereng, Tone; Moen, Lena Haugland; Lyshaug, Lars; Koidis, Anastasios; Delgado-Pando, Gonzalo; Stratakos, Alexandros Ch; Boeri, Marco; From, Cecilie; Syed, Hyat; Muccioli, Mirko; Mulazzani, Roberto; Halbert, Catherine

2017-01-01

A prototype decision support IT-tool for the food industry was developed in the STARTEC project. Typical processes and decision steps were mapped using real life production scenarios of participating food companies manufacturing complex ready-to-eat foods. Companies looked for a more integrated approach when making food safety decisions that would align with existing HACCP systems. The tool was designed with shelf life assessments and data on safety, quality, and costs, using a pasta salad meal as a case product. The process flow chart was used as starting point, with simulation options at each process step. Key parameters like pH, water activity, costs of ingredients and salaries, and default models for calculations of Listeria monocytogenes , quality scores, and vitamin C, were placed in an interactive database. Customization of the models and settings was possible on the user-interface. The simulation module outputs were provided as detailed curves or categorized as "good"; "sufficient"; or "corrective action needed" based on threshold limit values set by the user. Possible corrective actions were suggested by the system. The tool was tested and approved by end-users based on selected ready-to-eat food products. Compared to other decision support tools, the STARTEC-tool is product-specific and multidisciplinary and includes interpretation and targeted recommendations for end-users.

The STARTEC Decision Support Tool for Better Tradeoffs between Food Safety, Quality, Nutrition, and Costs in Production of Advanced Ready-to-Eat Foods

PubMed Central

Gefferth, Andras; Spajic, Miroslav; Estanga, Edurne Gaston; Vitali, Silvia; Pasquali, Frederique; Bovo, Federica; Manfreda, Gerardo; Mancusi, Rocco; Tessema, Girum Tadesse; Fagereng, Tone; Moen, Lena Haugland; Lyshaug, Lars; Koidis, Anastasios; Delgado-Pando, Gonzalo; Stratakos, Alexandros Ch.; Boeri, Marco; From, Cecilie; Syed, Hyat; Muccioli, Mirko; Mulazzani, Roberto; Halbert, Catherine

2017-01-01

A prototype decision support IT-tool for the food industry was developed in the STARTEC project. Typical processes and decision steps were mapped using real life production scenarios of participating food companies manufacturing complex ready-to-eat foods. Companies looked for a more integrated approach when making food safety decisions that would align with existing HACCP systems. The tool was designed with shelf life assessments and data on safety, quality, and costs, using a pasta salad meal as a case product. The process flow chart was used as starting point, with simulation options at each process step. Key parameters like pH, water activity, costs of ingredients and salaries, and default models for calculations of Listeria monocytogenes, quality scores, and vitamin C, were placed in an interactive database. Customization of the models and settings was possible on the user-interface. The simulation module outputs were provided as detailed curves or categorized as “good”; “sufficient”; or “corrective action needed” based on threshold limit values set by the user. Possible corrective actions were suggested by the system. The tool was tested and approved by end-users based on selected ready-to-eat food products. Compared to other decision support tools, the STARTEC-tool is product-specific and multidisciplinary and includes interpretation and targeted recommendations for end-users. PMID:29457031

Sensponsive architecture as a tool to stimulate the senses and alleviate the psychological disorders of an individual.

PubMed

Liapi, Marianthi; Linaraki, Despoina; Voradaki, Georgia

2012-08-01

The paper presents an ongoing research project that aims to help individuals with mild psychological disorders, like depression, to reduce the use of medication and escape a possible addiction to drugs by transforming their immediate or broader living space into a sensponsive environment. It is an innovative, multidisciplinary, non-invasive approach through the domains of architecture, computer science, psychology and endocrinology. Initially, the paper presents the connections between space and human behavior, and specifically, the ways in which the spatial qualities of the surrounding environment affect the human senses and consequently the hormonal changes and the production of the corresponding emotions and actions. As a next step, the paper outlines the creation of sensponsive environments that are programmed to sense human discomfort by monitoring changes in facial expression and body movement and respond to them accordingly by transforming their spatial elements in order to make people feel better. The proposed sensponsive spaces are equipped with biomedical monitoring systems, smart materials and sensor-actuator assemblies with programmed re-actions (haptic, olfactory, chromatic and so on) that help people refine their feeling of the surrounding space, guiding its smooth transition to a comfortable--for the body and the mind-place. The paper concludes with the next step of this research initiative, the sensponsive suit, a personalized wearable assembly enhanced with technology to positively affect the psychological health of the wearer.

Fluctuations of the experience of togetherness within the team over time: task-cohesion and shared understanding throughout a sporting regular season.

PubMed

Bourbousson, Jérôme; Fortes-Bourbousson, Marina

2017-06-01

Based on a diagnosis action research design, the present study assessed the fluctuations of the team experience of togetherness. Reported experiences of 12 basketball team members playing in the under-18 years old national championship were studied during a four-month training and competitive period. Time series analysis (Auto-Regressive Integrated Moving Average procedures) served to describe temporal properties of the way in which the fluctuations of task-cohesion and shared understanding were step-by-step experienced over time, respectively. Correlations, running-correlations and cross-lagged correlations were used to describe the temporal links that governed the relationships between both phenomena. The results indicated that the task-cohesion dimensions differed mainly for shared understanding dynamics in that their time fluctuations were not embedded in external events, and that the variations in shared understanding tend to precede 'individual attractions to the task' variations with seven team practical sessions. This study argues for further investigation of how 'togetherness' is experienced alternatively as a feeling of cohesion or shared understanding. Practitioner Summary: The present action research study investigated the experience that the team members have to share information during practice, and the subsequent benefices on team cohesion. Results call for specific interventions that make team members accept the fluctuating nature of team phenomena, to help them maintaining their daily efforts.

Nursing Practices in Catholic Healthcare: A Case Study of Nurses in a Catholic Private Hospital.

PubMed

Edward, Karen-Leigh; Giandinoto, Jo-Ann; Mills, Cally; Kay, Kate

2017-11-07

We aimed to investigate Catholic Identity and Mission communication specifically how nurses were expressing the Catholic healthcare values in practice. A mixed-methods, case study design was used and included non-participant observation, a mid-level manager focus group (n = 7) and online surveys (n = 144). Document and observational data analysis revealed the organisation's commitment to visible indication of Catholic values adherence. Focus group analysis revealed two themes, 'Catholic values in action' and 'taking the extra step'. The impact of Catholic Identity and Mission on nurses and nursing care recipients remains elusive and warrants further understanding.

Ligand Binding: Molecular Mechanics Calculation of the Streptavidin-Biotin Rupture Force

NASA Astrophysics Data System (ADS)

Grubmuller, Helmut; Heymann, Berthold; Tavan, Paul

1996-02-01

The force required to rupture the streptavidin-biotin complex was calculated here by computer simulations. The computed force agrees well with that obtained by recent single molecule atomic force microscope experiments. These simulations suggest a detailed multiple-pathway rupture mechanism involving five major unbinding steps. Binding forces and specificity are attributed to a hydrogen bond network between the biotin ligand and residues within the binding pocket of streptavidin. During rupture, additional water bridges substantially enhance the stability of the complex and even dominate the binding inter-actions. In contrast, steric restraints do not appear to contribute to the binding forces, although conformational motions were observed.

Keeping Hawai’i’s forest birds one step ahead of avian diseases in a warming world: a focus on Hakalau Forest National Wildlife Refuge. A case study from the National Conservation and Training Center Structured Decision Making Workshop

USGS Publications Warehouse

Paxton, Eben H.; Burgett, Jeff; McDonald-Fadden, Eve; Bean, Ellen; Atkinson, Carter T.; Ball, Donna; Cole, Colleen; Crampton, Lisa H.; Kraus, Jim; LaPointe, Dennis A.; Mehrhoff, Loyal; Samuel, Michael D.; Brewer, Donna; Converse, Sarah J.; Morey, Steve

2011-01-01

This report is a product of a one-week workshop on using Structured Decision Making to identify and prioritize conservation actions to address the threat of climate change on Hawaii‟s native forest bird community. Specifically, t his report addresses the issue of global warming ‟s likely role in increasing disease prevalence in upper elevation forests of Hawaii, negatively impacting native bird populations susceptible to the disease but currently disease - free because of the cooler temperatures at high elevations. 

The neuropsychology of self-reflection in psychiatric illness

PubMed Central

Philippi, Carissa L.; Koenigs, Michael

2014-01-01

The development of robust neuropsychological measures of social and affective function—which link critical dimensions of mental health to their underlying neural circuitry—could be a key step in achieving a more pathophysiologically-based approach to psychiatric medicine. In this article, we summarize research indicating that self-reflection (the inward attention to personal thoughts, memories, feelings, and actions) may be a useful model for developing such a paradigm, as there is evidence that self-reflection is (1) measurable with self-report scales and performance-based tests, (2) linked to the activity of a specific neural circuit, and (3) dimensionally related to mental health and various forms of psychopathology. PMID:24685311

Integrating Land Cover Modeling and Adaptive Management to Conserve Endangered Species and Reduce Catastrophic Fire Risk

NASA Technical Reports Server (NTRS)

Breininger, David; Duncan, Brean; Eaton, Mitchell; Johnson, Fred; Nichols, James

2014-01-01

Land cover modeling is used to inform land management, but most often via a two-step process where science informs how management alternatives can influence resources and then decision makers can use this to make decisions. A more efficient process is to directly integrate science and decision making, where science allows us to learn to better accomplish management objectives and is developed to address specific decisions. Co-development of management and science is especially productive when decisions are complicated by multiple objectives and impeded by uncertainty. Multiple objectives can be met by specification of tradeoffs, and relevant uncertainty can be addressed through targeted science (i.e., models and monitoring). We describe how to integrate habitat and fuels monitoring with decision making focused on dual objectives of managing for endangered species and minimizing catastrophic fire risk. Under certain conditions, both objectives might be achieved by a similar management policy, but habitat trajectories suggest tradeoffs. Knowledge about system responses to actions can be informed by applying competing management actions to different land units in the same system state and by ideas about fire behavior. Monitoring and management integration is important to optimize state-specific management decisions and increase knowledge about system responses. We believe this approach has broad utility for and cover modeling programs intended to inform decision making.

Haiti Recovery Act

THOMAS, 111th Congress

Sen. Dodd, Christopher J. [D-CT

2010-01-28

House - 03/09/2010 Held at the desk. (All Actions) Notes: For further action, see H.R.4573, which became Public Law 111-158 on 4/26/2010. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

PREEMIE Reauthorization Act

THOMAS, 113th Congress

Rep. Eshoo, Anna G. [D-CA-18

2013-02-06

House - 02/08/2013 Referred to the Subcommittee on Health. (All Actions) Notes: For further action, see S.252, which became Public Law 113-55 on 11/27/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Smart Savings Act

THOMAS, 113th Congress

Sen. Warren, Elizabeth [D-MA

2014-03-12

House - 09/17/2014 Held at the desk. (All Actions) Notes: For further action, see H.R.4193, which became Public Law 113-255 on 12/18/2014. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

MAP-21

THOMAS, 112th Congress

Sen. Boxer, Barbara [D-CA

2011-11-07

04/24/2012 See also H.R. 4348. (All Actions) Notes: For further action, see H.R.6064, which became Public Law 112-140 on 6/29/2012. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Consolidated Appropriations Act, 2012

THOMAS, 112th Congress

Rep. Rogers, Harold [R-KY-5

2011-12-14

House - 12/14/2011 Referred to House Budget (All Actions) Notes: For further action, see H.R.2055, which became Public Law 112-74 on 12/23/2011. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Supplemental Appropriations Act, 2010

THOMAS, 111th Congress

Rep. Lewis, Jerry [R-CA-41

2010-07-15

House - 07/15/2010 Referred to House Budget (All Actions) Notes: For further action, see H.R.4899, which became Public Law 111-212 on 7/29/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

America Invents Act

THOMAS, 112th Congress

Sen. Leahy, Patrick J. [D-VT

2011-01-25

House - 03/09/2011 Held at the desk. (All Actions) Notes: For further action, see H.R.1249, which became Public Law 112-29 on 9/16/2011. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Sunscreen Innovation Act

THOMAS, 113th Congress

Rep. Whitfield, Ed [R-KY-1

2014-03-13

Senate - 07/29/2014 Received in the Senate. (All Actions) Notes: For further action, see S.2141, which became Public Law 113-195 on 11/26/2014. Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

Deconstructing the roles of glucocorticoids in adipose tissue biology and the development of central obesity.

PubMed

Lee, Mi-Jeong; Pramyothin, Pornpoj; Karastergiou, Kalypso; Fried, Susan K

2014-03-01

Central obesity is associated with insulin resistance and dyslipidemia. Thus, the mechanisms that control fat distribution and its impact on systemic metabolism have importance for understanding the risk for diabetes and cardiovascular disease. Hypercortisolemia at the systemic (Cushing's syndrome) or local levels (due to adipose-specific overproduction via 11β-hydroxysteroid dehydrogenase 1) results in the preferential expansion of central, especially visceral fat depots. At the same time, peripheral subcutaneous depots can become depleted. The biochemical and molecular mechanisms underlying the depot-specific actions of glucocorticoids (GCs) on adipose tissue function remain poorly understood. GCs exert pleiotropic effects on adipocyte metabolic, endocrine and immune functions, and dampen adipose tissue inflammation. GCs also regulate multiple steps in the process of adipogenesis. Acting synergistically with insulin, GCs increase the expression of numerous genes involved in fat deposition. Variable effects of GC on lipolysis are reported, and GC can improve or impair insulin action depending on the experimental conditions. Thus, the net effect of GC on fat storage appears to depend on the physiologic context. The preferential effects of GC on visceral adipose tissue have been linked to higher cortisol production and glucocorticoid receptor expression, but the molecular details of the depot-dependent actions of GCs are only beginning to be understood. In addition, increasing evidence underlines the importance of circadian variations in GCs in relationship to the timing of meals for determining their anabolic actions on the adipocyte. In summary, although the molecular mechanisms remain to be fully elucidated, there is increasing evidence that GCs have multiple, depot-dependent effects on adipocyte gene expression and metabolism that promote central fat deposition. This article is part of a Special Issue entitled: Modulation of Adipose Tissue in Health and Disease. Copyright © 2013 Elsevier B.V. All rights reserved.

Solid waste management of small island developing states-the case of the Seychelles: a systemic and collaborative study of Swiss and Seychellois students to support policy.

PubMed

Meylan, Grégoire; Lai, Adelene; Hensley, John; Stauffacher, Michael; Krütli, Pius

2018-05-15

Solid waste management (SWM) is a significant challenge for the Seychelles. Waste generation, fueled by economic development and tourism, increases steadily, while landfilling continues to be the main disposal path, thus exacerbating the island nation's specific weaknesses. Due to the small scale of the Seychelles economy, there is little capital available to stimulate innovations in SWM and generate the knowledge for setting priorities and guiding SWM action. Students from ETH Zurich and UniSey conducted a transdisciplinary case study (tdCS) to fill this knowledge gap and gain insights into the obstacles and opportunities related to sustainable SWM. The tdCS approach allowed students to gain comprehensive and in-depth knowledge about the SWM system required to set priorities for action and next steps. The government should streamline the different financial frameworks according to a clear principle (e.g., polluter pays principle). Specific biogenic waste streams represent a potential source of energy and fertilizers. Expanding the scope and densifying the network of collection points could help raise recycling rates of other waste fractions. Diverting biogenic waste and recycling more glass, metals, paper, and plastics would also significantly reduce landfilling rates. Regardless of future amounts of waste ending up on landfills, the latter must be reengineered before the surrounding environment suffers major adverse impacts. All these actions imply a government-driven approach which integrates the views of stakeholders and consumers alike.

Using the Intervention Mapping Protocol to develop an online video intervention for parents to prevent childhood obesity: Movie Models.

PubMed

De Lepeleere, Sara; Verloigne, Maïté; Brown, Helen Elizabeth; Cardon, Greet; De Bourdeaudhuij, Ilse

2016-08-08

The increasing prevalence of childhood overweight/obesity caused by an unhealthy diet, insufficient physical activity (PA) and high levels of sedentary behaviour (SB) is a prominent public health concern. Parenting practices may contribute to healthy behaviour change in children, but well-researched examples are limited. The aim of this study is to describe the systematic development of an intervention for parents to prevent childhood overweight/obesity through the improvement of parenting practices. The six steps of the Intervention Mapping Protocol (IMP), a theory- and evidence-based tool to develop health-related interventions, were used as a framework to develop the 'Movie Models' programme. In Step 1, a needs assessment was performed to better understand the health problem of overweight/obesity in children and its association with diet, PA and SB. In Step 2, the programme goal (increasing the adoption of effective parenting practices) was sub-divided into performance objectives. Change objectives, which specify explicit actions required to accomplish the performance objectives, were also identified. Step 3 included the selection of theoretical methods (e.g. 'modelling' and 'images'), which were then translated into the practical strategy of online parenting videos. Step 4 comprised the development of a final intervention framework, and Step 5 included the planning of programme adoption and implementation. The final phase, Step 6, included the development of an effect- and process-evaluation plan. The IMP was used to structure the development of 'Movie Models', an intervention targeting specific parenting practices related to children's healthy diet, PA, SB, and parental self-efficacy. A clear framework for process analyses is offered, which aims to increase the potential effectiveness of an intervention and can be useful for those developing health promotion programmes. © The Author(s) 2016.

Six steps to an effective denials management program.

PubMed

Robertson, Brian; Doré, Alexander

2005-09-01

The following six steps can help you manage denials management issues in your organization: Create standard definitions of denial types. Establish a denial hierarchy. Establish a centralized denial database. Develop key performance indicators. Build responsibility matrices. Measure, monitor, and take action.

Moving the Strategic Plan off the Shelf and into Action at the University of Wisconsin-Madison

ERIC Educational Resources Information Center

Paris, Kathleen A.

2004-01-01

The author describes practical steps for infusing the strategic plan throughout the organization. These steps have carried the University of Wisconsin--Madison effectively through two cycles of reaccreditation and planning. (Contains 1 figure.)

SANE Deployment Act

THOMAS, 113th Congress

Rep. Lipinski, Daniel [D-IL-3

2013-05-15

House - 06/20/2013 Referred to the Subcommittee on Military Personnel. (All Actions) Notes: For further action, see H.R.3304, which became Public Law 113-66 on 12/26/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Domestic Minor Sex Trafficking Deterrence and Victims Support Act of 2010

THOMAS, 111th Congress

Sen. Wyden, Ron [D-OR

2009-12-22

Senate - 12/21/2010 Message on House action received in Senate and at desk: House amendment to Senate bill. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

TBI Treatment Act

THOMAS, 113th Congress

Rep. Sessions, Pete [R-TX-32

2013-06-12

House - 08/29/2013 Referred to the Subcommittee on Military Personnel. (All Actions) Notes: For further action, see H.R.3304, which became Public Law 113-66 on 12/26/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Longline Catcher Processor Subsector Single Fishery Cooperative Act

THOMAS, 111th Congress

Rep. Larsen, Rick [D-WA-2

2009-10-22

House - 07/27/2010 Subcommittee Hearings Held. (All Actions) Notes: For further action, see S.1609, which became Public Law 111-335 on 12/22/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Affirmative Action: Equal Opportunity for Women in Library Management

ERIC Educational Resources Information Center

DeFichy, Wendy

1973-01-01

Women can achieve equal opportunity in library management through Affirmative Action Committees. Several steps are suggested: the determination of present status; assessment of library policies affecting hiring, parental leave and promotion; some strategies to attain managerial positions. (21 references) (Author)

Healing Our Heroes Act

THOMAS, 113th Congress

Rep. Broun, Paul C. [R-GA-10

2014-01-29

House - 02/11/2014 Referred to the Subcommittee on Health. (All Actions) Notes: For further action, see H.R.5771, which became Public Law 113-295 on 12/19/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Drought Information Act of 2013

THOMAS, 113th Congress

Sen. Pryor, Mark L. [D-AR

2013-02-25

House - 02/04/2014 Held at the desk. (All Actions) Notes: For further action, see H.R.2431, which became Public Law 113-86 on 3/6/2014. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Pilot's Bill of Rights

THOMAS, 112th Congress

Rep. Graves, Sam [R-MO-6

2012-01-24

House - 01/25/2012 Referred to the Subcommittee on Aviation. (All Actions) Notes: For further action, see S.1335, which became Public Law 112-153 on 8/3/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Harriet Tubman National Historical Parks Act

THOMAS, 113th Congress

Rep. Maffei, Daniel B. [D-NY-24

2013-02-13

House - 06/06/2013 Subcommittee Hearings Held. (All Actions) Notes: For further action, see H.R.3979, which became Public Law 113-291 on 12/19/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

12 CFR 702.204 - Prompt corrective action for “critically undercapitalized” credit unions

Code of Federal Regulations, 2010 CFR

2010-01-01

... rates of interest on insured deposits in its relevant market area; (13) Other action to carry out prompt... complying with the quarterly timetable of steps and meeting the quarterly net worth targets prescribed in an...

Telework Enhancement Act of 2010

THOMAS, 111th Congress

Sen. Akaka, Daniel K. [D-HI

2009-03-25

House - 05/25/2010 Held at the desk. (All Actions) Notes: For further action, see H.R.1722, which became Public Law 111-292 on 12/9/2010. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Veteran Skills to Jobs Act

THOMAS, 112th Congress

Sen. Nelson, Bill [D-FL

2012-03-27

House - 07/09/2012 Held at the desk. (All Actions) Notes: For further action, see H.R.4155, which became Public Law 112-147 on 7/23/2012. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Fort Pulaski National Monument Lease Authorization Act

THOMAS, 112th Congress

Rep. Kingston, Jack [R-GA-1

2011-07-28

House - 09/15/2011 Subcommittee Hearings Held. (All Actions) Notes: For further action, see S.535, which became Public Law 112-69 on 12/19/2011. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

HOPE Act

THOMAS, 111th Congress

Rep. Hoekstra, Peter [R-MI-2

2010-02-04

House - 02/04/2010 Referred to the House Committee on the Judiciary. (All Actions) Notes: For further action, see H.R.5283, which became Public Law 111-293 on 12/9/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Frank Buckles World War I Memorial Act

THOMAS, 112th Congress

Rep. Poe, Ted [R-TX-2

2011-03-08

House - 01/24/2012 Subcommittee Hearings Held. (All Actions) Notes: For further action, see H.R.6364, which became Public Law 112-272 on 1/14/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

A bill to designate the United States courthouse located at 211 South Court Street, Rockford, Illinois, as the "Stanley J. Roszkowski United States Courthouse".

THOMAS, 111th Congress

Sen. Durbin, Richard J. [D-IL

2009-02-05

House - 04/23/2009 For further action see P.L. 111-14. (All Actions) Notes: For further action, see S.520, which became Public Law 111-14 on 4/23/2009. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Youth Action Council on Sustainable Innovation (YACSI) Report: Making Innovation Sustainable Among Youth in Canada.

ERIC Educational Resources Information Center

2002

A study surveyed 241 high-achieving youth aged 15-25 regarding how innovation can be made sustainable among youth in Canada. Results were insightful and pointed to actionable steps for the Youth Action Council for Sustainable Innovation and the federal government. Findings indicated the following: youth can be more innovative if they have the…

Morris K. Udall Scholarship and Excellence in National Environmental Policy Amendments Act of 2009

THOMAS, 111th Congress

Rep. Grijalva, Raul M. [D-AZ-7

2009-02-12

Senate - 10/08/2009 Message on House action received in Senate and at desk: House amendment to Senate amendment. (All Actions) Notes: For further action, see S.1818, which became Public Law 111-90 on 11/3/2009. Tracker: This bill has the status Resolving DifferencesHere are the steps for Status of Legislation:

To amend the Digital Television Transition and Public Safety Act of 2005 to extend the interoperable emergency communications grant program through fiscal year 2012.

THOMAS, 111th Congress

Rep. Cao, Anh "Joseph" [R-LA-2

2009-03-31

House - 10/08/2009 FOR FURTHER ACTION, see H.R. 3633. (All Actions) Notes: For further action, see S.1694, which became Public Law 111-96 on 11/6/2009. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

To amend the Digital Television Transition and Public Safety Act of 2005 to extend the interoperable emergency communications grant program through fiscal year 2012.

THOMAS, 111th Congress

Rep. Cao, Anh "Joseph" [R-LA-2

2009-07-27

House - 10/08/2009 FOR FURTHER ACTION, see H.R. 3633. (All Actions) Notes: For further action, see S.1694, which became Public Law 111-96 on 11/6/2009. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Sexual Conflict and Seminal Fluid Proteins: A Dynamic Landscape of Sexual Interactions

PubMed Central

Sirot, Laura K.; Wong, Alex; Chapman, Tracey; Wolfner, Mariana F.

2015-01-01

Sexual reproduction requires coordinated contributions from both sexes to proceed efficiently. However, the reproductive strategies that the sexes adopt often have the potential to give rise to sexual conflict because they can result in divergent, sex-specific costs and benefits. These conflicts can occur at many levels, from molecular to behavioral. Here, we consider sexual conflict mediated through the actions of seminal fluid proteins. These proteins provide many excellent examples in which to trace the operation of sexual conflict from molecules through to behavior. Seminal fluid proteins are made by males and provided to females during mating. As agents that can modulate egg production at several steps, as well as reproductive behavior, sperm “management,” and female feeding, activity, and longevity, the actions of seminal proteins are prime targets for sexual conflict. We review these actions in the context of sexual conflict. We discuss genomic signatures in seminal protein (and related) genes that are consistent with current or previous sexual conflict. Finally, we note promising areas for future study and highlight real-world practical situations that will benefit from understanding the nature of sexual conflicts mediated by seminal proteins. PMID:25502515

Sexual conflict and seminal fluid proteins: a dynamic landscape of sexual interactions.

PubMed

Sirot, Laura K; Wong, Alex; Chapman, Tracey; Wolfner, Mariana F

2014-12-11

Sexual reproduction requires coordinated contributions from both sexes to proceed efficiently. However, the reproductive strategies that the sexes adopt often have the potential to give rise to sexual conflict because they can result in divergent, sex-specific costs and benefits. These conflicts can occur at many levels, from molecular to behavioral. Here, we consider sexual conflict mediated through the actions of seminal fluid proteins. These proteins provide many excellent examples in which to trace the operation of sexual conflict from molecules through to behavior. Seminal fluid proteins are made by males and provided to females during mating. As agents that can modulate egg production at several steps, as well as reproductive behavior, sperm "management," and female feeding, activity, and longevity, the actions of seminal proteins are prime targets for sexual conflict. We review these actions in the context of sexual conflict. We discuss genomic signatures in seminal protein (and related) genes that are consistent with current or previous sexual conflict. Finally, we note promising areas for future study and highlight real-world practical situations that will benefit from understanding the nature of sexual conflicts mediated by seminal proteins. Copyright © 2015 Cold Spring Harbor Laboratory Press; all rights reserved.

A functional approach to movement analysis and error identification in sports and physical education

PubMed Central

Hossner, Ernst-Joachim; Schiebl, Frank; Göhner, Ulrich

2015-01-01

In a hypothesis-and-theory paper, a functional approach to movement analysis in sports is introduced. In this approach, contrary to classical concepts, it is not anymore the “ideal” movement of elite athletes that is taken as a template for the movements produced by learners. Instead, movements are understood as the means to solve given tasks that in turn, are defined by to-be-achieved task goals. A functional analysis comprises the steps of (1) recognizing constraints that define the functional structure, (2) identifying sub-actions that subserve the achievement of structure-dependent goals, (3) explicating modalities as specifics of the movement execution, and (4) assigning functions to actions, sub-actions and modalities. Regarding motor-control theory, a functional approach can be linked to a dynamical-system framework of behavioral shaping, to cognitive models of modular effect-related motor control as well as to explicit concepts of goal setting and goal achievement. Finally, it is shown that a functional approach is of particular help for sports practice in the context of structuring part practice, recognizing functionally equivalent task solutions, finding innovative technique alternatives, distinguishing errors from style, and identifying root causes of movement errors. PMID:26441717

Long-term Transfer of Learning from Books and Videos during Toddlerhood

PubMed Central

Brito, Natalie; Barr, Rachel; McIntyre, Paula; Simcock, Gabrielle

2011-01-01

Television viewing and picture book reading are prevalent activities during toddlerhood and research has shown that toddlers can imitate from both books and videos after short delays (Barr & Hayne, 1999; Simcock & DeLoache, 2006). This is the first study to directly compare toddlers’ long-term retention rates for target actions learned from a video or book. Toddlers (N = 158) aged 18- and 24-months saw an experimenter demonstrating how to make a novel 3-step toy rattle via a pre-recorded video or a picture book. The toddlers’ imitation of the target actions was tested after a specific delay (e.g., 2 weeks, 4 weeks) and their performance was compared to that of age-matched controls who did not see a demonstration. The 18-month-olds retained the target actions for 2 weeks, exhibiting forgetting at 4 weeks, whereas the 24-month-olds retained the information for up to 4 weeks, exhibiting forgetting at 8 weeks. Retention rates for books and videos did not differ at either age. These findings demonstrate very impressive retention from a brief 2D media demonstration and they contribute to our overall understanding of long-term memory processes during infancy. PMID:21911223

A Racial Equity Toolkit for Midwifery Organizations.

PubMed

Gordon, Wendy M

2016-11-01

Midwifery associations are increasing awareness and commitment to racial equity in the profession and in the communities we serve. Moving these commitments from words into action may be facilitated by a racial equity toolkit to help guide midwifery organizations to consider all policies, initiatives, and actions with a racial equity lens. Racial equity impact analyses have been used in recent years by various governmental agencies in the United States and abroad with positive results, and emerging literature indicates that nonprofit organizations are having similarly positive results. This article proposes a framework for midwifery organizations to incorporate a racial equity toolkit, starting with explicit intentions of the organization with regard to racial equity in the profession. Indicators of success are elucidated as the next step, followed by the use of a racial equity impact analysis worksheet. This worksheet is applied by teams or committees when considering new policies or initiatives to examine those actions through a racial equity lens. An organizational change team and equity advisory groups are essential in assisting organizational leadership to forecast potential negative and positive impacts. Examples of the components of a midwifery-specific racial equity toolkit are included. © 2016 by the American College of Nurse-Midwives.

Long-term transfer of learning from books and video during toddlerhood.

PubMed

Brito, Natalie; Barr, Rachel; McIntyre, Paula; Simcock, Gabrielle

2012-01-01

Television viewing and picture book reading are prevalent activities during toddlerhood, and research has shown that toddlers can imitate from both books and videos after short delays. This is the first study to directly compare toddlers' long-term retention rates for target actions learned from a video or book. Toddlers (N=158) at 18- and 24-months of age saw an experimenter demonstrating how to make a novel three-step toy rattle via a prerecorded video or a picture book. The toddlers' imitation of the target actions was tested after a specific delay (e.g., 2, 4 weeks), and their performance was compared with that of age-matched controls who did not see a demonstration. The 18-month-olds retained the target actions for 2 weeks, exhibiting forgetting at 4 weeks, whereas the 24-month-olds retained the information for up to 4 weeks, exhibiting forgetting at 8 weeks. Retention rates for books and videos did not differ at either age. These findings demonstrate very impressive retention from a brief two-dimensional media demonstration, and they contribute to our overall understanding of long-term memory processes during infancy. Copyright © 2011 Elsevier Inc. All rights reserved.

10 Steps for Implementing Change.

ERIC Educational Resources Information Center

Marsee, Jeff

2002-01-01

Offers steps for adapting the change process to institutional culture: align leadership style with organizational culture, don't overuse change missionaries, protect change agents, define the problem, maintain focus when the project drifts, identify and remove barriers before implementing action plans, assign responsibilities to individuals,…

A Viral Packaging Motor Varies Its DNA Rotation and Step Size to Preserve Subunit Coordination as the Capsid Fills

PubMed Central

Tafoya, Sara; Aathavan, K.; Schnitzbauer, Joerg; Grimes, Shelley; Jardine, Paul J.; Bustamante, Carlos

2014-01-01

SUMMARY Multimeric, ring-shaped molecular motors rely on the coordinated action of their subunits to perform crucial biological functions. During these tasks, motors often change their operation in response to regulatory signals. Here, we investigate a viral packaging machine as it fills the capsid with DNA and encounters increasing internal pressure. We find that the motor rotates the DNA during packaging and that the rotation per basepair increases with filling. This change accompanies a reduction in the motor’s step size. We propose that these adjustments preserve motor coordination by allowing one subunit to make periodic, specific, and regulatory contacts with the DNA. At high filling, we also observe the down-regulation of the ATP-binding rate and the emergence of long-lived pauses, suggesting a throttling-down mechanism employed by the motor near the completion of packaging. This study illustrates how a biological motor adjusts its operation in response to changing conditions, while remaining highly coordinated. PMID:24766813

Impact of Marine Drugs on Animal Reproductive Processes

PubMed Central

Silvestre, Francesco; Tosti, Elisabetta

2009-01-01

The discovery and description of bioactive substances from natural sources has been a research topic for the last 50 years. In this respect, marine animals have been used to extract many new compounds exerting different actions. Reproduction is a complex process whose main steps are the production and maturation of gametes, their activation, the fertilisation and the beginning of development. In the literature it has been shown that many substances extracted from marine organisms may have profound influence on the reproductive behaviour, function and reproductive strategies and survival of species. However, despite the central importance of reproduction and thus the maintenance of species, there are still few studies on how reproductive mechanisms are impacted by marine bioactive drugs. At present, studies in either marine and terrestrial animals have been particularly important in identifying what specific fine reproductive mechanisms are affected by marine-derived substances. In this review we describe the main steps of the biology of reproduction and the impact of substances from marine environment and organisms on the reproductive processes. PMID:20098597

Kinetic measures of restabilisation during volitional stepping reveal age-related alterations in the control of mediolateral dynamic stability.

PubMed

Singer, Jonathan C; McIlroy, William E; Prentice, Stephen D

2014-11-07

Research examining age-related changes in dynamic stability during stepping has recognised the importance of the restabilisation phase, subsequent to foot-contact. While regulation of the net ground reaction force (GRFnet) line of action is believed to influence dynamic stability during steady-state locomotion, such control during restabilisation remains unknown. This work explored the origins of age-related decline in mediolateral dynamic stability by examining the line of action of GRFnet relative to the centre of mass (COM) during restabilisation following voluntary stepping. Healthy younger and older adults (n=20 per group) performed three single-step tasks (varying speed and step placement), altering the challenge to stability control. Age-related differences in magnitude and intertrial variability of the angle of divergence of GRFnet line of action relative to the COM were quantified, along with the peak mediolateral and vertical GRFnet components. The angle of divergence was further examined at discrete points during restabilisation, to uncover events of potential importance to stability control. Older adults exhibited a reduced angle of divergence throughout restabilisation. Temporal and spatial constraints on stepping increased the magnitude and intertrial variability of the angle of divergence, although not differentially among the older adults. Analysis of the time-varying angle of divergence revealed age-related reductions in magnitude, with increases in timing and intertrial timing variability during the later phase of restabilisation. This work further supports the idea that age-related challenges in lateral stability control emerge during restabilisation. Age-related alterations during the later phase of restabilisation may signify challenges with reactive control. Copyright © 2014 Elsevier Ltd. All rights reserved.

Corrective Action Decision Document/Corrective Action Plan for Corrective Action Unit 98: Frenchman Flat, Nevada National Security Site, Nevada, Revision 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Irene Farnham and Sam Marutzky

2011-07-01

This CADD/CAP follows the Corrective Action Investigation (CAI) stage, which results in development of a set of contaminant boundary forecasts produced from groundwater flow and contaminant transport modeling of the Frenchman Flat CAU. The Frenchman Flat CAU is located in the southeastern portion of the NNSS and comprises 10 underground nuclear tests. The tests were conducted between 1965 and 1971 and resulted in the release of radionuclides in the subsurface in the vicinity of the test cavities. Two important aspects of the corrective action process are presented within this CADD/CAP. The CADD portion describes the results of the Frenchman Flatmore » CAU data-collection and modeling activities completed during the CAI stage. The corrective action objectives and the actions recommended to meet the objectives are also described. The CAP portion describes the corrective action implementation plan. The CAP begins with the presentation of CAU regulatory boundary objectives and initial use restriction boundaries that are identified and negotiated by NNSA/NSO and the Nevada Division of Environmental Protection (NDEP). The CAP also presents the model evaluation process designed to build confidence that the flow and contaminant transport modeling results can be used for the regulatory decisions required for CAU closure. The first two stages of the strategy have been completed for the Frenchman Flat CAU. A value of information analysis and a CAIP were developed during the CAIP stage. During the CAI stage, a CAIP addendum was developed, and the activities proposed in the CAIP and addendum were completed. These activities included hydrogeologic investigation of the underground testing areas, aquifer testing, isotopic and geochemistry-based investigations, and integrated geophysical investigations. After these investigations, a groundwater flow and contaminant transport model was developed to forecast contaminant boundaries that enclose areas potentially exceeding the Safe Drinking Water Act radiological standards at any time within 1,000 years. An external peer review of the groundwater flow and contaminant transport model was completed, and the model was accepted by NDEP to allow advancement to the CADD/CAP stage. The CADD/CAP stage focuses on model evaluation to ensure that existing models provide adequate guidance for the regulatory decisions regarding monitoring and institutional controls. Data-collection activities are identified and implemented to address key uncertainties in the flow and contaminant transport models. During the CR stage, final use restriction boundaries and CAU regulatory boundaries are negotiated and established; a long-term closure monitoring program is developed and implemented; and the approaches and policies for institutional controls are initiated. The model evaluation process described in this plan consists of an iterative series of five steps designed to build confidence in the site conceptual model and model forecasts. These steps are designed to identify data-collection activities (Step 1), document the data-collection activities in the 0CADD/CAP (Step 2), and perform the activities (Step 3). The new data are then assessed; the model is refined, if necessary; the modeling results are evaluated; and a model evaluation report is prepared (Step 4). The assessments are made by the modeling team and presented to the pre-emptive review committee. The decision is made by the modeling team with the assistance of the pre-emptive review committee and concurrence of NNSA/NSO to continue data and model assessment/refinement, recommend additional data collection, or recommend advancing to the CR stage. A recommendation to advance to the CR stage is based on whether the model is considered to be sufficiently reliable for designing a monitoring system and developing effective institutional controls. The decision to advance to the CR stage or to return to step 1 of the process is then made by NDEP (Step 5).« less

Shared Decision-Making as the Future of Emergency Cardiology.

PubMed

Probst, Marc A; Noseworthy, Peter A; Brito, Juan P; Hess, Erik P

2018-02-01

Shared decision-making is playing an increasingly large role in emergency cardiovascular care. Although there are many challenges to successfully performing shared decision-making in the emergency department, there are numerous clinical scenarios in which it should be used. In this article, we explore new research and emerging decision aids in the following emergency care scenarios: (1) low-risk chest pain; (2) new-onset atrial fibrillation; and (3) moderate-risk syncope. These decision aids are designed to engage patients and facilitate shared decision-making for specific treatment and disposition (admit vs discharge) decisions. We then offer a 3-step, practical approach to performing shared decision-making in the acute care setting, on the basis of broad stakeholder input and previous conceptual work. Step 1 involves simply acknowledging that a clinical decision needs to be made. Step 2 involves a shared discussion about the working diagnosis and the options for care in the context of the patient's values, preferences, and circumstances. The third and final step requires the patient and provider to agree on a plan of action regarding further medical care. The implementation of shared decision-making in emergency cardiology has the potential to shift the paradigm of clinical practice from paternalism toward mutualism and improve the quality and experience of care for our patients. Copyright © 2017 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.

Denali National Park Improvement Act

THOMAS, 113th Congress

Rep. Young, Don [R-AK-At Large

2013-02-06

House - 09/20/2013 Placed on the Union Calendar, Calendar No. 157. (All Actions) Notes: For further action, see S.157, which became Public Law 113-33 on 9/18/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Flood Safe Basements Act

THOMAS, 113th Congress

Rep. Cramer, Kevin [R-ND-At Large

2014-01-09

House - 01/09/2014 Referred to the House Committee on Financial Services. (All Actions) Notes: For further action, see H.R.3370, which became Public Law 113-89 on 3/21/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Cabin Fee Act of 2014

THOMAS, 113th Congress

Rep. Hastings, Doc [R-WA-4

2014-06-17

House - 06/19/2014 Ordered to be Reported by Unanimous Consent. (All Actions) Notes: For further action, see H.R.3979, which became Public Law 113-291 on 12/19/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

RACE for Space Act

THOMAS, 112th Congress

Rep. Posey, Bill [R-FL-15

2012-04-19

House - 07/10/2012 Referred to the Subcommittee on Strategic Forces. (All Actions) Notes: For further action, see H.R.4310, which became Public Law 112-239 on 1/2/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Accuracy for Adoptees Act

THOMAS, 113th Congress

Rep. Smith, Lamar [R-TX-21

2013-10-30

House - 01/09/2014 Referred to the Subcommittee on Immigration and Border Security. (All Actions) Notes: For further action, see S.1614, which became Public Law 113-74 on 1/16/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Small Business Penalty Fairness Act of 2009

THOMAS, 111th Congress

Sen. Baucus, Max [D-MT

2009-12-18

House - 02/22/2010 Held at the desk. (All Actions) Notes: For further action, see H.R.5297, which became Public Law 111-240 on 9/27/2010. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

United States Anti-Doping Agency Reauthorization Act

THOMAS, 113th Congress

Rep. Johnson, Bill [R-OH-6

2014-09-18

House - 09/19/2014 Referred to the Subcommittee on Health. (All Actions) Notes: For further action, see S.2338, which became Public Law 113-280 on 12/18/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Intelligence Authorization Act for Fiscal Year 2010

THOMAS, 111th Congress

Sen. Feinstein, Dianne [D-CA

2010-07-19

House - 08/09/2010 Held at the desk. (All Actions) Notes: For further action, see H.R.2701, which became Public Law 111-259 on 10/7/2010. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Miami Dade College Land Conveyance Act

THOMAS, 111th Congress

Sen. Nelson, Bill [D-FL

2009-04-02

House - 06/19/2009 Held at the desk. (All Actions) Notes: For further action, see H.R.838, which became Public Law 111-48 on 8/12/2009. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Assessing Progress in Haiti Act

THOMAS, 113th Congress

Rep. Lee, Barbara [D-CA-13

2013-04-25

House - 06/07/2013 Referred to the Subcommittee on the Western Hemisphere. (All Actions) Notes: For further action, see S.1104, which became Public Law 113-162 on 8/8/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Enhanced Partnership with Pakistan Act of 2009

THOMAS, 111th Congress

Sen. Kerry, John F. [D-MA

2009-05-04

House - 06/25/2009 Held at the desk. (All Actions) Notes: For further action, see S.1707, which became Public Law 111-73 on 10/15/2009. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

To require the Commodity Futures Trading Commission to take certain actions to reduce excessive speculation in energy markets.

THOMAS, 112th Congress

Rep. Hinchey, Maurice D. [D-NY-22

2012-04-19

House - 05/10/2012 Referred to the Subcommittee on General Farm Commodities and Risk Management. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Rural Hospital Access Act of 2013

THOMAS, 113th Congress

Rep. Reed, Tom [R-NY-23

2013-04-26

House - 06/03/2013 Referred to the Subcommittee on Health. (All Actions) Notes: For further action, see H.R.4302, which became Public Law 113-93 on 4/1/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Keeping Flood Insurance Affordable Act of 2013

THOMAS, 113th Congress

Rep. Capuano, Michael E. [D-MA-7

2013-11-15

House - 11/15/2013 Referred to House Rules (All Actions) Notes: For further action, see H.R.3370, which became Public Law 113-89 on 3/21/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

American Fighter Aces Congressional Gold Medal Act

THOMAS, 113th Congress

Sen. Manchin, Joe, III [D-WV

2013-12-15

House - 03/27/2014 Held at the desk. (All Actions) Notes: For further action, see H.R.685, which became Public Law 113-105 on 5/23/2014. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Crow Tribe Water Rights Settlement Act of 2009

THOMAS, 111th Congress

Rep. Rehberg, Denny [R-MT-At Large

2009-09-15

House - 09/22/2009 Subcommittee Hearings Held. (All Actions) Notes: For further action, see H.R.4783, which became Public Law 111-291 on 12/8/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Mandatory Price Reporting Act of 2010

THOMAS, 111th Congress

Rep. Peterson, Collin C. [D-MN-7

2010-07-26

House - 07/28/2010 Ordered to be Reported by Voice Vote. (All Actions) Notes: For further action, see S.3656, which became Public Law 111-239 on 9/27/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Kids First Research Act of 2013

THOMAS, 113th Congress

Rep. Harper, Gregg [R-MS-3

2013-04-25

House - 06/03/2013 Referred to the Subcommittee on Health. (All Actions) Notes: For further action, see H.R.2019, which became Public Law 113-94 on 4/3/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

HIV Organ Policy Equity Act

THOMAS, 113th Congress

Rep. Capps, Lois [D-CA-24

2013-02-14

House - 07/30/2013 Placed on the Union Calendar, Calendar No. 129. (All Actions) Notes: For further action, see S.330, which became Public Law 113-51 on 11/21/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Honor the WISH Act

THOMAS, 112th Congress

Rep. Cohen, Steve [D-TN-9

2011-03-11

House - 03/18/2011 Referred to the Subcommittee on Military Personnel. (All Actions) Notes: For further action, see H.R.1540, which became Public Law 112-81 on 12/31/2011. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Disaster Relief Appropriations Act, 2013

THOMAS, 112th Congress

Rep. Rogers, Harold [R-KY-5

2011-02-11

Senate - 12/30/2012 Message on Senate action sent to the House. (All Actions) Notes: This bill was for a time the Senate legislative vehicle for Hurricane Sandy supplemental appropriations. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Territorial Omnibus Act of 2013

THOMAS, 113th Congress

Rep. Sablan, Gregorio Kilili Camacho [D-MP-At Large

2013-05-23

House - 07/08/2013 Referred to the Subcommittee on Workforce Protections. (All Actions) Notes: For further action, see S.256, which became Public Law 113-34 on 9/18/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Drug Sentencing Reform and Cocaine Kingpin Trafficking Act of 2009

THOMAS, 111th Congress

Rep. Jackson-Lee, Sheila [D-TX-18

2009-01-07

House - 05/21/2009 Subcommittee Hearings Held. (All Actions) Notes: For further action, see S.1789, which became Public Law 111-220 on 8/3/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Budget Control Act of 2011

THOMAS, 112th Congress

Sen. Leahy, Patrick J. [D-VT

2011-03-17

Senate - 08/01/2011 Considered by Senate. (consideration: CR S5156) (All Actions) Notes: For further action, see S.365, which became Public Law 112-25 on 8/2/2011. Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

Water Resources Development Act of 2013

THOMAS, 113th Congress

Sen. Boxer, Barbara [D-CA

2013-03-18

10/31/2013 See also H.R. 3080. (All Actions) Notes: For further action, see H.R.3080, which became Public Law 113-121 on 6/10/2014. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Averting the Fiscal Cliff Act

THOMAS, 112th Congress

Rep. Jordan, Jim [R-OH-4

2012-12-19

House - 12/19/2012 Referred to the Subcommittee on Health. (All Actions) Notes: For further action, see H.R.8, which became Public Law 112-240 on 1/2/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Ukraine Freedom Support Act of 2014

THOMAS, 113th Congress

Sen. Menendez, Robert [D-NJ

2014-09-16

House - 12/11/2014 Held at the desk. (All Actions) Notes: For further action, see H.R.5859, which became Public Law 113-272 on 12/18/2014. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

National Alzheimer's Project Act

THOMAS, 111th Congress

Rep. Markey, Edward J. [D-MA-7

2010-02-25

House - 02/25/2010 Referred to the House Committee on Energy and Commerce. (All Actions) Notes: For further action, see S.3036, which became Public Law 111-375 on 1/4/2011. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Border Tunnel Prevention Act of 2011

THOMAS, 112th Congress

Sen. Feinstein, Dianne [D-CA

2011-06-20

House - 01/31/2012 Held at the desk. (All Actions) Notes: For further action, see H.R.4119, which became Public Law 112-127 on 6/5/2012. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

To require the Commodity Futures Trading Commission to take certain actions to reduce excessive speculation in energy markets.

THOMAS, 112th Congress

Rep. Hochul, Kathleen C. [D-NY-26

2012-04-18

House - 05/10/2012 Referred to the Subcommittee on General Farm Commodities and Risk Management. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Fallen Firefighters Assistance Tax Clarification Act of 2013

THOMAS, 113th Congress

Sen. Schumer, Charles E. [D-NY

2013-11-13

12/13/2013 See also H.R. 3458. (All Actions) Notes: For further action, see H.R.3458, which became Public Law 113-63 on 12/20/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Ultralight Aircraft Smuggling Prevention Act of 2011

THOMAS, 112th Congress

Sen. Udall, Tom [D-NM

2011-12-08

House - 12/12/2011 Held at the desk. (All Actions) Notes: For further action, see H.R.3801, which became Public Law 112-93 on 2/10/2012. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Unnecessary Cap Act of 2013

THOMAS, 113th Congress

Rep. Reed, Tom [R-NY-23

2013-08-02

House - 08/02/2013 Referred to the Subcommittee on Health. (All Actions) Notes: For further action, see H.R.4302, which became Public Law 113-93 on 4/1/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

SPEECH Act

THOMAS, 111th Congress

Sen. Leahy, Patrick J. [D-VT

2010-06-22

Senate - 06/22/2010 Read twice and referred to the Committee on the Judiciary. (All Actions) Notes: For further action, see H.R.2765, which became Public Law 111-223 on 8/10/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Stability for Service Members Act

THOMAS, 113th Congress

Rep. Fincher, Stephen Lee [R-TN-8

2014-12-04

House - 12/23/2014 Referred to the Subcommittee on Economic Opportunity. (All Actions) Notes: For further action, see S.3008, which became Public Law 113-286 on 12/18/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Bonneville Unit Clean Hydropower Facilitation Act

THOMAS, 113th Congress

Sen. Hatch, Orrin G. [R-UT

2013-01-22

House - 06/20/2013 Held at the desk. (All Actions) Notes: For further action, see H.R.254, which became Public Law 113-20 on 7/18/2013. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Sibling Connections Act

THOMAS, 113th Congress

Sen. Grassley, Chuck [R-IA

2013-12-10

Senate - 12/10/2013 Read twice and referred to the Committee on Finance. (All Actions) Notes: For further action, see H.R.4980, which became Public Law 113-183 on 9/29/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

BLM Permit Processing Improvement Act of 2014

THOMAS, 113th Congress

Sen. Udall, Tom [D-NM

2014-06-05

House - 09/17/2014 Held at the desk. (All Actions) Notes: For further action, see H.R.3979, which became Public Law 113-291 on 12/19/2014. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Predisaster Hazard Mitigation Act of 2010

THOMAS, 111th Congress

Sen. Lieberman, Joseph I. [ID-CT

2010-04-22

House - 06/29/2010 Held at the desk. (All Actions) Notes: For further action, see H.R.1746, which became Public Law 111-351 on 1/4/2011. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

How to Radicalize Graduate Students: Take These Simple Steps to Intimidate, Alienate, and Agitate Your Own Flock of Graduate Students

ERIC Educational Resources Information Center

Steffen, Heather

2011-01-01

As the recession, budget cuts, endowment losses, and Republican governors gut university funding, campuses across the country have become host to occupations, union actions, and demonstrations. One can take steps to intimidate, alienate, and agitate a flock of graduate students. The author discusses steps that offer simple ways to rile up and…

Jasmonate signaling in plant stress responses and development - active and inactive compounds.

PubMed

Wasternack, Claus; Strnad, Miroslav

2016-09-25

Jasmonates (JAs) are lipid-derived signals mediating plant responses to biotic and abiotic stresses and in plant development. Following the elucidation of each step in their biosynthesis and the important components of perception and signaling, several activators, repressors and co-repressors have been identified which contribute to fine-tuning the regulation of JA-induced gene expression. Many of the metabolic reactions in which JA participates, such as conjugation with amino acids, glucosylation, hydroxylation, carboxylation, sulfation and methylation, lead to numerous compounds with different biological activities. These metabolites may be highly active, partially active in specific processes or inactive. Hydroxylation, carboxylation and sulfation inactivate JA signaling. The precursor of JA biosynthesis, 12-oxo-phytodienoic acid (OPDA), has been identified as a JA-independent signaling compound. An increasing number of OPDA-specific processes is being identified. To conclude, the numerous JA compounds and their different modes of action allow plants to respond specifically and flexibly to alterations in the environment. Copyright © 2015 Elsevier B.V. All rights reserved.

ATP analogues at a glance.

PubMed

Bagshaw, C

2001-02-01

ATP has long been known to play a central role in the energetics of cells both in transduction mechanisms and in metabolic pathways, and is involved in regulation of enzyme, channel and receptor activities. Numerous ATP analogues have been synthesised to probe the role of ATP in biosystems (Yount, 1975; Jameson and Eccleston, 1997; Bagshaw, 1998). In general, two contrasting strategies are employed. Modifications may be introduced deliberately to change the properties of ATP (e.g. making it non-hydrolysable) so as to perturb the chemical steps involved in its action. Typically these involve modification of the phosphate chain. Alternatively, derivatives (e.g. fluorescent probes) are designed to report on the action of ATP but have a minimal effect on its properties. ATP-utilising systems vary enormously in their specificity; so what acts as a good analogue in one case may be very poor in another. The accompanying poster shows a representative selection of derivatives that have been synthesised and summarises their key properties.

Processing and analysis of cardiac optical mapping data obtained with potentiometric dyes

PubMed Central

Laughner, Jacob I.; Ng, Fu Siong; Sulkin, Matthew S.; Arthur, R. Martin

2012-01-01

Optical mapping has become an increasingly important tool to study cardiac electrophysiology in the past 20 years. Multiple methods are used to process and analyze cardiac optical mapping data, and no consensus currently exists regarding the optimum methods. The specific methods chosen to process optical mapping data are important because inappropriate data processing can affect the content of the data and thus alter the conclusions of the studies. Details of the different steps in processing optical imaging data, including image segmentation, spatial filtering, temporal filtering, and baseline drift removal, are provided in this review. We also provide descriptions of the common analyses performed on data obtained from cardiac optical imaging, including activation mapping, action potential duration mapping, repolarization mapping, conduction velocity measurements, and optical action potential upstroke analysis. Optical mapping is often used to study complex arrhythmias, and we also discuss dominant frequency analysis and phase mapping techniques used for the analysis of cardiac fibrillation. PMID:22821993

Meta-analysis and psychophysiology: A tutorial using depression and action-monitoring event-related potentials.

PubMed

Moran, Tim P; Schroder, Hans S; Kneip, Chelsea; Moser, Jason S

2017-01-01

Meta-analyses are regularly used to quantitatively integrate the findings of a field, assess the consistency of an effect and make decisions based on extant research. The current article presents an overview and step-by-step tutorial of meta-analysis aimed at psychophysiological researchers. We also describe best-practices and steps that researchers can take to facilitate future meta-analysis in their sub-discipline. Lastly, we illustrate each of the steps by presenting a novel meta-analysis on the relationship between depression and action-monitoring event-related potentials - the error-related negativity (ERN) and the feedback negativity (FN). This meta-analysis found that the literature on depression and the ERN is contaminated by publication bias. With respect to the FN, the meta-analysis found that depression does predict the magnitude of the FN; however, this effect was dependent on the type of task used by the study. Copyright © 2016 Elsevier B.V. All rights reserved.

The European cooperative approach to securing critical information infrastructure.

PubMed

Purser, Steve

2011-10-01

This paper provides an overview of the EU approach to securing critical information infrastructure, as defined in the Action Plan contained in the Commission Communication of March 2009, entitled 'Protecting Europe from large-scale cyber-attacks and disruptions: enhancing preparedness, security and resilience' and further elaborated by the Communication of May 2011 on critical Information infrastructure protection 'Achievements and next steps: towards global cyber-security'. After explaining the need for pan-European cooperation in this area, the CIIP Action Plan is explained in detail. Finally, the current state of progress is summarised together with the proposed next steps.

Directed Selection of Recombinant Human Monoclonal Antibodies to Herpes Simplex Virus Glycoproteins from Phage Display Libraries

NASA Astrophysics Data System (ADS)

Sanna, Pietro Paolo; Williamson, R. Anthony; de Logu, Alessandro; Bloom, Floyd E.; Burton, Dennis R.

1995-07-01

Human monoclonal antibodies have considerable potential in the prophylaxis and treatment of viral disease. However, only a few such antibodies suitable for clinical use have been produced to date. We have previously shown that large panels of human recombinant monoclonal antibodies against a plethora of infectious agents, including herpes simplex virus types 1 and 2, can be established from phage display libraries. Here we demonstrate that facile cloning of recombinant Fab fragments against specific viral proteins in their native conformation can be accomplished by panning phage display libraries against viral glycoproteins "captured" from infected cell extracts by specific monoclonal antibodies immobilized on ELISA plates. We have tested this strategy by isolating six neutralizing recombinant antibodies specific for herpes simplex glycoprotein gD or gB, some of which are against conformationally sensitive epitopes. By using defined monoclonal antibodies for the antigen-capture step, this method can be used for the isolation of antibodies to specific regions and epitopes within the target viral protein. For instance, monoclonal antibodies to a nonneutralizing epitope can be used in the capture step to clone antibodies to neutralizing epitopes, or antibodies to a neutralizing epitope can be used to clone antibodies to a different neutralizing epitope. Furthermore, by using capturing antibodies to more immunodominant epitopes, one can direct the cloning to less immunogenic ones. This method should be of value in generating antibodies to be used both in the prophylaxis and treatment of viral infections and in the characterization of the mechanisms of antibody protective actions at the molecular level.

Targeting Membrane-Bound Viral RNA Synthesis Reveals Potent Inhibition of Diverse Coronaviruses Including the Middle East Respiratory Syndrome Virus

PubMed Central

Bergström, Tomas; Kann, Nina; Adamiak, Beata; Hannoun, Charles; Kindler, Eveline; Jónsdóttir, Hulda R.; Muth, Doreen; Kint, Joeri; Forlenza, Maria; Müller, Marcel A.; Drosten, Christian; Thiel, Volker; Trybala, Edward

2014-01-01

Coronaviruses raise serious concerns as emerging zoonotic viruses without specific antiviral drugs available. Here we screened a collection of 16671 diverse compounds for anti-human coronavirus 229E activity and identified an inhibitor, designated K22, that specifically targets membrane-bound coronaviral RNA synthesis. K22 exerts most potent antiviral activity after virus entry during an early step of the viral life cycle. Specifically, the formation of double membrane vesicles (DMVs), a hallmark of coronavirus replication, was greatly impaired upon K22 treatment accompanied by near-complete inhibition of viral RNA synthesis. K22-resistant viruses contained substitutions in non-structural protein 6 (nsp6), a membrane-spanning integral component of the viral replication complex implicated in DMV formation, corroborating that K22 targets membrane bound viral RNA synthesis. Besides K22 resistance, the nsp6 mutants induced a reduced number of DMVs, displayed decreased specific infectivity, while RNA synthesis was not affected. Importantly, K22 inhibits a broad range of coronaviruses, including Middle East respiratory syndrome coronavirus (MERS–CoV), and efficient inhibition was achieved in primary human epithelia cultures representing the entry port of human coronavirus infection. Collectively, this study proposes an evolutionary conserved step in the life cycle of positive-stranded RNA viruses, the recruitment of cellular membranes for viral replication, as vulnerable and, most importantly, druggable target for antiviral intervention. We expect this mode of action to serve as a paradigm for the development of potent antiviral drugs to combat many animal and human virus infections. PMID:24874215

Intact action segmentation in Parkinson's disease: Hypothesis testing using a novel computational approach.

PubMed

Schiffer, Anne-Marike; Nevado-Holgado, Alejo J; Johnen, Andreas; Schönberger, Anna R; Fink, Gereon R; Schubotz, Ricarda I

2015-11-01

Action observation is known to trigger predictions of the ongoing course of action and thus considered a hallmark example for predictive perception. A related task, which explicitly taps into the ability to predict actions based on their internal representations, is action segmentation; the task requires participants to demarcate where one action step is completed and another one begins. It thus benefits from a temporally precise prediction of the current action. Formation and exploitation of these temporal predictions of external events is now closely associated with a network including the basal ganglia and prefrontal cortex. Because decline of dopaminergic innervation leads to impaired function of the basal ganglia and prefrontal cortex in Parkinson's disease (PD), we hypothesised that PD patients would show increased temporal variability in the action segmentation task, especially under medication withdrawal (hypothesis 1). Another crucial aspect of action segmentation is its reliance on a semantic representation of actions. There is no evidence to suggest that action representations are substantially altered, or cannot be accessed, in non-demented PD patients. We therefore expected action segmentation judgments to follow the same overall patterns in PD patients and healthy controls (hypothesis 2), resulting in comparable segmentation profiles. Both hypotheses were tested with a novel classification approach. We present evidence for both hypotheses in the present study: classifier performance was slightly decreased when it was tested for its ability to predict the identity of movies segmented by PD patients, and a measure of normativity of response behaviour was decreased when patients segmented movies under medication-withdrawal without access to an episodic memory of the sequence. This pattern of results is consistent with hypothesis 1. However, the classifier analysis also revealed that responses given by patients and controls create very similar action-specific patterns, thus delivering evidence in favour hypothesis 2. In terms of methodology, the use of classifiers in the present study allowed us to establish similarity of behaviour across groups (hypothesis 2). The approach opens up a new avenue that standard statistical methods often fail to provide and is discussed in terms of its merits to measure hypothesised similarities across study populations. Copyright © 2015 Elsevier Ltd. All rights reserved.

Expressing the sense of the Congress that State and local governments should be supported for taking actions to discourage illegal immigration and that legislation should be enacted to ease the burden on State and local governments for taking such actions.

THOMAS, 111th Congress

Rep. Poe, Ted [R-TX-2

2009-01-09

House - 02/09/2009 Referred to the Subcommittee on Immigration, Citizenship, Refugees, Border Security, and International Law. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

To require the Secretary of Homeland Security to conduct a program in the maritime environment for the mobile biometric identification of suspected individuals, including terrorists, to enhance border security.

THOMAS, 111th Congress

Rep. Bilirakis, Gus M. [R-FL-9

2009-01-28

10/23/2009 For Further Action See H.R.3619. (All Actions) Notes: For further action, see H.R.3619, which became Public Law 111-281 on 10/15/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Intercountry Adoption Universal Accreditation Act of 2012

THOMAS, 112th Congress

Rep. Sires, Albio [D-NJ-13

2012-06-26

House - 06/26/2012 Referred to the House Committee on Foreign Affairs. (All Actions) Notes: For further action, see S.3331, which became Public Law 112-276 on 1/14/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

SMART Prevention Act of 2013

THOMAS, 113th Congress

Sen. Whitehouse, Sheldon [D-RI

2013-01-24

Senate - 01/24/2013 Read twice and referred to the Committee on the Judiciary. (All Actions) Notes: For further action, see S.47, which became Public Law 113-4 on 3/7/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Aviation Jobs and Safety Act of 2011

THOMAS, 112th Congress

Rep. Costello, Jerry F. [D-IL-12

2011-07-26

House - 07/27/2011 Referred to the Subcommittee on Aviation. (All Actions) Notes: For further action, see H.R.1079, which became Public Law 112-7 on 3/31/2011. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Airport and Airway Extension Act of 2011, Part IV

THOMAS, 112th Congress

Sen. Rockefeller, John D., IV [D-WV

2011-07-19

07/21/2011 Sponsor introductory remarks on measure. (All Actions) Notes: For further action, see H.R.2553, which became Public Law 112-27 on 8/5/2011. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Small Business Intermediary Lending Pilot Program Act of 2010

THOMAS, 111th Congress

Rep. Kilroy, Mary Jo [D-OH-15

2010-05-18

05/20/2010 Sponsor introductory remarks on measure. (All Actions) Notes: For further action, see H.R.5297, which became Public Law 111-240 on 9/27/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

BLM Live Internet Auctions Act

THOMAS, 113th Congress

Rep. Johnson, Bill [R-OH-6

2013-02-06

House - 09/10/2013 Placed on the Union Calendar, Calendar No. 148. (All Actions) Notes: For further action, see H.R.3979, which became Public Law 113-291 on 12/19/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Disabled Military Child Protection Act of 2013

THOMAS, 113th Congress

Rep. Moran, James P. [D-VA-8

2013-06-04

House - 08/29/2013 Referred to the Subcommittee on Military Personnel. (All Actions) Notes: For further action, see H.R.3979, which became Public Law 113-291 on 12/19/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Judicial Survivors Protection Act of 2009

THOMAS, 111th Congress

Rep. Johnson, Henry C. "Hank," Jr. [D-GA-4

2009-07-22

House - 09/14/2009 Referred to the Subcommittee on Courts and Competition Policy. (All Actions) Notes: For further action, see S.1107, which became Public Law 111-49 on 8/12/2009. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Coast Guard Modernization Act of 2009

THOMAS, 111th Congress

Rep. Oberstar, James L. [D-MN-8

2009-06-02

House - 12/03/2009 Placed on the Union Calendar, Calendar No. 203. (All Actions) Notes: For further action, see H.R.3619, which became Public Law 111-281 on 10/15/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Weapon Systems Acquisition Reform Act of 2009

THOMAS, 111th Congress

Rep. Tauscher, Ellen O. [D-CA-10

2009-03-31

House - 03/31/2009 Referred to the House Committee on Armed Services. (All Actions) Notes: For further action, see S.454, which became Public Law 111-23 on 5/22/2009. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

American Recovery and Reinvestment Act of 2009

THOMAS, 111th Congress

Sen. Baucus, Max [D-MT

2009-01-29

Senate - 01/30/2009 Star Print ordered on the bill. (All Actions) Notes: For further action, see H.R.1, which became Public Law 111-5 on 2/17/2009. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

School District 318 Land Exchange Act

THOMAS, 113th Congress

Rep. Nolan, Richard M. [D-MN-8

2014-03-12

House - 12/22/2014 Placed on the Union Calendar, Calendar No. 528. (All Actions) Notes: For further action, see H.R.3979, which became Public Law 113-291 on 12/19/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Columbine-Hondo Wilderness Act

THOMAS, 113th Congress

Rep. Lujan, Ben Ray [D-NM-3

2013-04-23

House - 05/02/2013 Referred to the Subcommittee on Public Lands and Environmental Regulation. (All Actions) Notes: For further action, see H.R.3979, which became Public Law 113-291 on 12/19/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Blackfoot River Land Exchange Act of 2014

THOMAS, 113th Congress

Rep. Simpson, Michael K. [R-ID-2

2014-07-09

House - 12/01/2014 Placed on the Union Calendar, Calendar No. 479. (All Actions) Notes: For further action, see S.2040, which became Public Law 113-232 on 12/16/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Water Resources Development Act of 2010

THOMAS, 111th Congress

Rep. Oberstar, James L. [D-MN-8

2010-07-28

House - 09/29/2010 Placed on the Union Calendar, Calendar No. 391. (All Actions) Notes: For further action, see H.R.6184, which became Public Law 111-315 on 12/18/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

State Child Welfare Innovation Act

THOMAS, 112th Congress

Sen. Baucus, Max [D-MT

2011-05-17

Senate - 05/17/2011 Read twice and referred to the Committee on Finance. (All Actions) Notes: For further action, see H.R.2883, which became Public Law 112-34 on 9/30/2011. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Restoring American Financial Stability Act of 2010

THOMAS, 111th Congress

Sen. Dodd, Christopher J. [D-CT

2010-04-15

Senate - 05/25/2010 Returned to the Calendar. Calendar No. 349. (All Actions) Notes: For further action, see H.R.4173, which became Public Law 111-203 on 7/21/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

PEPFAR Stewardship and Oversight Act of 2013

THOMAS, 113th Congress

Rep. Engel, Eliot L. [D-NY-16

2013-09-25

House - 09/25/2013 Referred to the House Committee on Foreign Affairs. (All Actions) Notes: For further action, see S.1545, which became Public Law 113-56 on 12/2/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Investor Protection Act of 2009

THOMAS, 111th Congress

Rep. Kanjorski, Paul E. [D-PA-11

2009-10-15

House - 12/17/2010 Placed on the Union Calendar, Calendar No. 408. (All Actions) Notes: For further action, see H.R.4173, which became Public Law 111-203 on 7/21/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Medicare IVIG Access Act

THOMAS, 112th Congress

Sen. Kerry, John F. [D-MA

2011-05-12

Senate - 05/12/2011 Read twice and referred to the Committee on Finance. (All Actions) Notes: For further action, see H.R.1845, which became Public Law 112-242 on 1/10/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

IMPACT Act of 2014

THOMAS, 113th Congress

Sen. Wyden, Ron [D-OR

2014-06-26

Senate - 06/26/2014 Read twice and referred to the Committee on Finance. (All Actions) Notes: For further action, see H.R.4994, which became Public Law 113-185 on 10/6/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Veterans Health Care Budget Reform and Transparency Act of 2009

THOMAS, 111th Congress

Sen. Akaka, Daniel K. [D-HI

2009-02-12

08/06/2009 See also H.R. 1016. (All Actions) Notes: For further action, see H.R.1016, which became Public Law 111-81 on 10/22/2009. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Airline Flight Crew Technical Corrections Act

THOMAS, 111th Congress

Rep. Bishop, Timothy H. [D-NY-1

2009-02-09

House - 03/23/2009 Referred to the Subcommittee on Workforce Protections. (All Actions) Notes: For further action, see S.1422, which became Public Law 111-119 on 12/21/2009. Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

Salmon Lake Land Selection Resolution Act

THOMAS, 112th Congress

Rep. Young, Don [R-AK-At Large

2011-01-12

House - 01/26/2011 Referred to the Subcommittee Indian and Alaska Native Affairs. (All Actions) Notes: For further action, see S.292, which became Public Law 112-133 on 6/15/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Limestone Hills Training Area Withdrawal Act

THOMAS, 113th Congress

Rep. Daines, Steve [R-MT-At Large

2013-04-23

House - 06/24/2013 Placed on the Union Calendar, Calendar No. 86. (All Actions) Notes: For further action, see H.R.3304, which became Public Law 113-66 on 12/26/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

A bill to require the Commodity Futures Trading Commission to take certain actions to reduce excessive speculation in energy markets.

THOMAS, 112th Congress

Sen. Sanders, Bernard [I-VT

2012-03-21

Senate - 03/21/2012 Read twice and referred to the Committee on Agriculture, Nutrition, and Forestry. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Animal Generic Drug User Fee Amendments of 2013

THOMAS, 113th Congress

Rep. Gardner, Cory [R-CO-4

2013-04-09

House - 04/12/2013 Referred to the Subcommittee on Health. (All Actions) Notes: For further action, see S.622, which became Public Law 113-14 on 6/13/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Restore Online Shoppers' Confidence Act

THOMAS, 111th Congress

Rep. Space, Zachary T. [D-OH-18

2010-07-01

House - 07/01/2010 Referred to the House Committee on Energy and Commerce. (All Actions) Notes: For further action, see S.3386, which became Public Law 111-345 on 12/29/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Animal Drug User Fee Amendments of 2013

THOMAS, 113th Congress

Rep. Shimkus, John [R-IL-15

2013-04-09

House - 08/02/2013 Placed on the Union Calendar, Calendar No. 135. (All Actions) Notes: For further action, see S.622, which became Public Law 113-14 on 6/13/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Alicia Dawn Koehl Respect for National Cemeteries Act

THOMAS, 113th Congress

Rep. Brooks, Susan W. [R-IN-5

2013-09-17

House - 11/06/2013 Referred to the Subcommittee on Military Personnel. (All Actions) Notes: For further action, see S.1471, which became Public Law 113-65 on 12/20/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Intelligence Authorization Act for Fiscal Year 2010

THOMAS, 111th Congress

Sen. Feinstein, Dianne [D-CA

2009-07-22

House - 02/25/2010 Rule H. Res. 1105 passed House. (All Actions) Notes: For further action, see H.R.2701, which became Public Law 111-259 on 10/7/2010. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Generic Drug and Biosimilar User Fee Act of 2012

THOMAS, 112th Congress

Rep. Murphy, Tim [R-PA-18

2012-02-08

House - 02/10/2012 Referred to the Subcommittee on Health. (All Actions) Notes: For further action, see S.3187, which became Public Law 112-144 on 7/9/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Campus Sexual Violence Elimination Act

THOMAS, 113th Congress

Rep. Maloney, Carolyn B. [D-NY-12

2013-02-25

House - 04/23/2013 Referred to the Subcommittee on Higher Education and Workforce Training. (All Actions) Notes: For further action, see S.47, which became Public Law 113-4 on 3/7/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Surface Transportation Extension Act of 2012

THOMAS, 112th Congress

Rep. Mica, John L. [R-FL-7

2012-03-28

House - 04/30/2012 Referred to the Subcommittee on Energy and Power. (All Actions) Notes: For further action, see H.R.6064, which became Public Law 112-140 on 6/29/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Sandy Recovery Improvement Act of 2013

THOMAS, 113th Congress

Rep. Denham, Jeff [R-CA-10

2013-01-14

Senate - 12/20/2013 Indefinitely postponed by Senate by Unanimous Consent. (All Actions) Notes: For further action, see H.R.152, which became Public Law 113-2 on 1/29/2013. Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

Fair Military Leave Act

THOMAS, 112th Congress

Sen. Kohl, Herb [D-WI

2012-02-01

Senate - 02/01/2012 Read twice and referred to the Committee on Armed Services. (All Actions) Notes: For further action, see H.R.4310, which became Public Law 112-239 on 1/2/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

FAA Air Transportation Modernization and Safety Improvement Act

THOMAS, 112th Congress

Sen. Rockefeller, John D., IV [D-WV

2011-01-27

04/07/2011 See also H.R. 658. (All Actions) Notes: For further action, see H.R.658, which became Public Law 112-95 on 2/14/2012. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Federal Data Center Consolidation Act of 2013

THOMAS, 113th Congress

Sen. Bennet, Michael F. [D-CO

2013-10-30

House - 09/19/2014 Referred to House Armed Services (All Actions) Notes: For further action, see H.R.3979, which became Public Law 113-291 on 12/19/2014. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Lions Clubs International Century of Service Commemorative Coin Act

THOMAS, 112th Congress

Sen. Moran, Jerry [R-KS

2011-06-29

House - 07/30/2012 Held at the desk. (All Actions) Notes: For further action, see H.R.2139, which became Public Law 112-181 on 10/5/2012. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Creating American Jobs Through Foreign Capital Investment Act

THOMAS, 112th Congress

Sen. Leahy, Patrick J. [D-VT

2011-03-17

Senate - 12/07/2011 Committee on the Judiciary. Hearings held. (All Actions) Notes: For further action, see S.3245, which became Public Law 112-176 on 9/28/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

SAFER Act of 2013

THOMAS, 113th Congress

Sen. Cornyn, John [R-TX

2013-01-23

Senate - 01/23/2013 Read twice and referred to the Committee on the Judiciary. (All Actions) Notes: For further action, see S.47, which became Public Law 113-4 on 3/7/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

A Plus Act

THOMAS, 112th Congress

Rep. Bass, Karen [D-CA-33

2012-05-31

House - 09/26/2012 Referred to the Subcommittee on Early Childhood, Elementary, and Secondary Education. (All Actions) Notes: For further action, see S.3472, which became Public Law 112-278 on 1/14/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Elizabeth A. Connelly Act

THOMAS, 111th Congress

Rep. McMahon, Michael E. [D-NY-13

2010-01-27

House - 02/23/2010 Referred to the Subcommittee on Early Childhood, Elementary, and Secondary Education. (All Actions) Notes: For further action, see S.2781, which became Public Law 111-256 on 10/5/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Firearms Fairness and Affordability Act

THOMAS, 111th Congress

Sen. Baucus, Max [D-MT

2009-03-18

Senate - 03/18/2009 Read twice and referred to the Committee on Finance. (All Actions) Notes: For further action, see H.R.5552, which became Public Law 111-237 on 8/16/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Commerce, Justice, Science, and Related Agencies Appropriations Act, 2012

THOMAS, 112th Congress

Sen. Mikulski, Barbara A. [D-MD

2011-09-15

10/17/2011 See also H.R. 2112. (All Actions) Notes: For further action, see H.R.2112, which became Public Law 112-55 on 11/18/2011. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Commerce, Justice, Science, and Related Agencies Appropriations Act, 2012

THOMAS, 112th Congress

Rep. Wolf, Frank R. [R-VA-10

2011-07-20

10/17/2011 See also H.R. 2112. (All Actions) Notes: For further action, see H.R.2112, which became Public Law 112-55 on 11/18/2011. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Ukraine Support Act

THOMAS, 113th Congress

Rep. Royce, Edward R. [R-CA-39

2014-03-21

Senate - 04/02/2014 Read twice and referred to the Committee on Foreign Relations. (All Actions) Notes: For further action, see S.2183, which became Public Law 113-96 on 4/3/2014. Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

Improving Nutrition for America's Children Act

THOMAS, 111th Congress

Rep. Miller, George [D-CA-7

2010-06-10

House - 09/13/2010 Referred to the Subcommittee on Healthy Families and Communities. (All Actions) Notes: For further action, see S.3307, which became Public Law 111-296 on 12/13/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

National Defense Authorization Act for Fiscal Year 2010

THOMAS, 111th Congress

Sen. Levin, Carl [D-MI

2009-07-02

House - 07/28/2009 Held at the desk. (All Actions) Notes: For further action, see H.R.2647, which became Public Law 111-84 on 10/28/2009. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Safe Doses Act

THOMAS, 112th Congress

Sen. Schumer, Charles E. [D-NY

2011-05-16

Senate - 08/28/2012 Placed on Senate Legislative Calendar under General Orders. Calendar No. 495. (All Actions) Notes: For further action, see H.R.4223, which became Public Law 112-186 on 10/5/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Maritime Safety Act of 2009

THOMAS, 111th Congress

Rep. Oberstar, James L. [D-MN-8

2009-06-02

House - 12/03/2009 Placed on the Union Calendar, Calendar No. 202. (All Actions) Notes: For further action, see H.R.3619, which became Public Law 111-281 on 10/15/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Platts-Van Hollen Whistleblower Protection Enhancement Act of 2011

THOMAS, 112th Congress

Rep. Issa, Darrell E. [R-CA-49

2011-11-01

House - 10/01/2012 Committee on Intelligence (Permanent) discharged. (All Actions) Notes: For further action, see S.743, which became Public Law 112-199 on 11/27/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Serve America Act

THOMAS, 111th Congress

Sen. Kennedy, Edward M. [D-MA

2009-01-16

Senate - 03/18/2009 Placed on Senate Legislative Calendar under General Orders. Calendar No. 34. (All Actions) Notes: For further action, see H.R.1388, which became Public Law 111-13 on 4/21/2009. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Enhanced Partnership with Pakistan Act of 2009

THOMAS, 111th Congress

Rep. Berman, Howard L. [D-CA-28

2009-09-24

House - 09/24/2009 Referred to the House Committee on Foreign Affairs. (All Actions) Notes: For further action, see S.1707, which became Public Law 111-73 on 10/15/2009. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Cooperative and Small Employer Charity Pension Flexibility Act

THOMAS, 113th Congress

Sen. Harkin, Tom [D-IA

2013-07-16

03/25/2014 See also H.R. 4275. (All Actions) Notes: For further action, see H.R.4275, which became Public Law 113-97 on 4/7/2014. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Get the Lead Out Act

THOMAS, 111th Congress

Rep. Eshoo, Anna G. [D-CA-14

2010-05-12

House - 05/12/2010 Referred to the House Committee on Energy and Commerce. (All Actions) Notes: For further action, see S.3874, which became Public Law 111-380 on 1/4/2011. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Patent Law Treaties Implementation Act of 2012

THOMAS, 112th Congress

Rep. Smith, Lamar [R-TX-21

2012-09-19

House - 09/19/2012 Referred to the House Committee on the Judiciary. (All Actions) Notes: For further action, see S.3486, which became Public Law 112-211 on 12/18/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Legislative Branch Appropriations Act, 2014

THOMAS, 113th Congress

Rep. Alexander, Rodney [R-LA-5

2013-07-23

House - 07/23/2013 Placed on the Union Calendar, Calendar No. 126. (All Actions) Notes: For further action, see H.R.3547, which became Public Law 113-76 on 1/17/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Freedom to Fish Act of 2013

THOMAS, 113th Congress

Rep. Whitfield, Ed [R-KY-1

2013-02-26

House - 02/27/2013 Referred to the Subcommittee on Water Resources and Environment. (All Actions) Notes: For further action, see S.982, which became Public Law 113-13 on 6/3/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

FISA Sunsets Reauthorization Act of 2011

THOMAS, 112th Congress

Rep. Sensenbrenner, F. James, Jr. [R-WI-5

2011-05-06

House - 05/18/2011 Placed on the Union Calendar, Calendar No. 40. (All Actions) Notes: For further action, see H.R.514, which became Public Law 112-3 on 2/25/2011. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Protecting Tenants at Foreclosure Act of 2009

THOMAS, 111th Congress

Rep. Ellison, Keith [D-MN-5

2009-03-02

House - 03/02/2009 Referred to the House Committee on Financial Services. (All Actions) Notes: For further action, see S.896, which became Public Law 111-22 on 5/20/2009. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Investigative Assistance for Violent Crimes Act of 2012

THOMAS, 112th Congress

Sen. Whitehouse, Sheldon [D-RI

2011-11-02

House - 12/18/2012 Held at the desk. (All Actions) Notes: For further action, see H.R.2076, which became Public Law 112-265 on 1/14/2013. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Federal Restricted Buildings and Grounds Improvement Act of 2011

THOMAS, 112th Congress

Sen. Blumenthal, Richard [D-CT

2011-11-02

House - 02/07/2012 Held at the desk. (All Actions) Notes: For further action, see H.R.347, which became Public Law 112-98 on 3/8/2012. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Sandia Pueblo Settlement Technical Amendment Act

THOMAS, 113th Congress

Rep. Lujan Grisham, Michelle [D-NM-1

2013-11-21

House - 04/01/2014 Placed on the Union Calendar, Calendar No. 295. (All Actions) Notes: For further action, see S.611, which became Public Law 113-119 on 6/9/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Cabin Fee Act of 2014

THOMAS, 113th Congress

Rep. Hastings, Doc [R-WA-4

2014-09-16

House - 12/22/2014 Placed on the Union Calendar, Calendar No. 538. (All Actions) Notes: For further action, see H.R.3979, which became Public Law 113-291 on 12/19/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Formaldehyde Standards for Composite Wood Products Act

THOMAS, 111th Congress

Rep. Matsui, Doris O. [D-CA-5

2010-03-10

House - 06/22/2010 Placed on the Union Calendar, Calendar No. 291. (All Actions) Notes: For further action, see S.1660, which became Public Law 111-199 on 7/7/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Money Remittances Improvement Act of 2013

THOMAS, 113th Congress

Rep. Ellison, Keith [D-MN-5

2013-04-24

House - 04/24/2013 Referred to the House Committee on Financial Services. (All Actions) Notes: For further action, see H.R.4386, which became Public Law 113-156 on 8/8/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Red Flag Program Clarification Act of 2010

THOMAS, 111th Congress

Rep. Adler, John H. [D-NJ-3

2010-11-17

House - 11/17/2010 Referred to the House Committee on Financial Services. (All Actions) Notes: For further action, see S.3987, which became Public Law 111-319 on 12/18/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Maritime Lien Reform Act

THOMAS, 112th Congress

Rep. Young, Don [R-AK-At Large

2011-03-17

House - 03/18/2011 Referred to the Subcommittee on Coast Guard and Maritime Transportation. (All Actions) Notes: For further action, see H.R.2838, which became Public Law 112-213 on 12/20/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Small Manufacturers Export Initiative Act

THOMAS, 111th Congress

Rep. Larsen, Rick [D-WA-2

2010-07-20

House - 07/23/2010 Referred to the Subcommittee on Technology and Innovation. (All Actions) Notes: For further action, see H.R.5297, which became Public Law 111-240 on 9/27/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Box Elder Utah Land Conveyance Act

THOMAS, 112th Congress

Rep. Bishop, Rob [R-UT-1

2011-03-30

House - 09/23/2011 Placed on the Union Calendar, Calendar No. 143. (All Actions) Notes: For further action, see S.683, which became Public Law 112-70 on 12/19/2011. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Anchorage Land Conveyance Act of 2013

THOMAS, 113th Congress

Rep. Young, Don [R-AK-At Large

2013-02-06

House - 12/16/2013 Placed on the Union Calendar, Calendar No. 216. (All Actions) Notes: For further action, see H.R.3979, which became Public Law 113-291 on 12/19/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Federal Buildings Personnel Training Act of 2010

THOMAS, 111th Congress

Rep. Carnahan, Russ [D-MO-3

2010-04-22

House - 11/30/2010 Placed on the Union Calendar, Calendar No. 394. (All Actions) Notes: For further action, see S.3250, which became Public Law 111-308 on 12/14/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Federal Retirement Reform Act of 2009

THOMAS, 111th Congress

Rep. Towns, Edolphus [D-NY-10

2009-03-31

House - 04/27/2009 Referred to the Subcommittee on Military Personnel. (All Actions) Notes: For further action, see H.R.1256, which became Public Law 111-31 on 6/22/2009. Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

Military Spouses Residency Relief Act

THOMAS, 111th Congress

Rep. Carter, John R. [R-TX-31

2009-02-25

House - 10/08/2009 Forwarded by Subcommittee to Full Committee by Voice Vote . (All Actions) Notes: For further action, see S.475, which became Public Law 111-97 on 11/11/2009. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Social Security Number Privacy and Identity Theft Prevention Act of 2009

THOMAS, 111th Congress

Rep. Tanner, John S. [D-TN-8

2009-07-23

07/24/2009 Sponsor introductory remarks on measure. (All Actions) Notes: For further action, see S.3789, which became Public Law 111-318 on 12/18/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Coltsville National Historical Park Act

THOMAS, 113th Congress

Rep. Larson, John B. [D-CT-1

2013-03-19

House - 04/01/2014 Placed on the Union Calendar, Calendar No. 290. (All Actions) Notes: For further action, see H.R.3979, which became Public Law 113-291 on 12/19/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Managing Athletic Liability: An Assessment Guide.

ERIC Educational Resources Information Center

Burling, Philip; And Others

1992-01-01

A comprehensive risk-management program associated with athletic activities contains the following essential components: (1) policies and procedures; (2) training; (3) supervision; (4) corrective action; (5) review and revision; (6) legal counsel and support. Action steps follow each of these major areas. (29 case references) (MLF)

Peace Corps Volunteer Service Improvement Act of 2011

THOMAS, 112th Congress

Rep. Ros-Lehtinen, Ileana [R-FL-18

2011-07-29

House - 09/21/2011 Ordered to be Reported by Unanimous Consent. (All Actions) Notes: For further action, see S.1280, which became Public Law 112-57 on 11/21/2011. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Intelligence Authorization Act for Fiscal Year 2014

THOMAS, 113th Congress

Rep. Rogers, Mike J. [R-MI-8

2013-10-30

House - 11/25/2013 Placed on the Union Calendar, Calendar No. 198. (All Actions) Notes: For further action, see S.1681, which became Public Law 113-126 on 7/7/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Continuing Extension Act of 2010

THOMAS, 111th Congress

Sen. Coburn, Tom [R-OK

2010-03-25

Senate - 03/25/2010 Read twice and referred to the Committee on Finance. (All Actions) Notes: For further action, see H.R.4851, which became Public Law 111-157 on 4/15/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Unemployment Supplemental Assistance Act

THOMAS, 111th Congress

Rep. McDermott, Jim [D-WA-7

2009-01-08

House - 01/08/2009 Referred to the House Committee on Ways and Means. (All Actions) Notes: For further action, see H.R.1, which became Public Law 111-5 on 2/17/2009. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Dignified Burial of Veterans Act of 2012

THOMAS, 112th Congress

Rep. Bilirakis, Gus M. [R-FL-9

2012-06-29

House - 06/29/2012 Referred to the House Committee on Veterans' Affairs. (All Actions) Notes: For further action, see S.3202, which became Public Law 112-260 on 1/10/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Mt. Andrea Lawrence Designation Act of 2011

THOMAS, 112th Congress

Rep. McKeon, Howard P. "Buck" [R-CA-25

2011-05-10

House - 05/30/2012 Placed on the House Calendar, Calendar No. 134. (All Actions) Notes: For further action, see S.925, which became Public Law 112-259 on 1/10/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Green Mountain Lookout Heritage Protection Act

THOMAS, 113th Congress

Rep. DelBene, Suzan K. [D-WA-1

2013-02-28

House - 01/23/2014 Placed on the Union Calendar, Calendar No. 244. (All Actions) Notes: For further action, see S.404, which became Public Law 113-99 on 4/15/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Unemployment Insurance Modernization Act

THOMAS, 111th Congress

Rep. McDermott, Jim [D-WA-7

2009-01-08

House - 01/08/2009 Referred to the House Committee on Ways and Means. (All Actions) Notes: For further action, see H.R.1, which became Public Law 111-5 on 2/17/2009. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

A whole school approach: collaborative development of school health policies, processes, and practices.

PubMed

Hunt, Pete; Barrios, Lisa; Telljohann, Susan K; Mazyck, Donna

2015-11-01

The Whole School, Whole Community, Whole Child (WSCC) model shows the interrelationship between health and learning and the potential for improving educational outcomes by improving health outcomes. However, current descriptions do not explain how to implement the model. The existing literature, including scientific articles, programmatic guidance, and publications by national agencies and organizations, was reviewed and synthesized to describe an overview of interrelatedness of learning and health and the 10 components of the WSCC model. The literature suggests potential benefits of applying the WSCC model at the district and school level. But, the model lacks specific guidance as to how this might be made actionable. A collaborative approach to health and learning is suggested, including a 10-step systematic process to help schools and districts develop an action plan for improving health and education outcomes. Essential preliminary actions are suggested to minimize the impact of the challenges that commonly derail systematic planning processes and program implementation, such as lack of readiness, personnel shortages, insufficient resources, and competing priorities. All new models require testing and evidence to confirm their value. District and schools will need to test this model and put plans into action to show that significant, substantial, and sustainable health and academic outcomes can be achieved. © 2015 The Authors. Journal of School Health published by Wiley Periodicals, Inc. on behalf of American School Health Association.

An ethogram for Benthic Octopods (Cephalopoda: Octopodidae).

PubMed

Mather, Jennifer A; Alupay, Jean S

2016-05-01

The present paper constructs a general ethogram for the actions of the flexible body as well as the skin displays of octopuses in the family Octopodidae. The actions of 6 sets of structures (mantle-funnel, arms, sucker-stalk, skin-web, head, and mouth) combine to produce behavioral units that involve positioning of parts leading to postures such as the flamboyant, movements of parts of the animal with relation to itself including head bob and grooming, and movements of the whole animal by both jetting in the water and crawling along the substrate. Muscular actions result in 4 key changes in skin display: (a) chromatophore expansion, (b) chromatophore contraction resulting in appearance of reflective colors such as iridophores and leucophores, (c) erection of papillae on the skin, and (d) overall postures of arms and mantle controlled by actions of the octopus muscular hydrostat. They produce appearances, including excellent camouflage, moving passing cloud and iridescent blue rings, with only a few known species-specific male visual sexual displays. Commonalities across the family suggest that, despite having flexible muscular hydrostat movement systems producing several behavioral units, simplicity of production may underlie the complexity of movement and appearance. This systematic framework allows researchers to take the next step in modeling how such diversity can be a combination of just a few variables. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

[Mobile team of palliative care in a department of neurology: value of two multidisciplinary and professional groups fruit of a joint distribution of the palliative approach and ethical support].

PubMed

Baudoin, D; Krebs, S

2013-04-01

This article describes how a mobile team of palliative care and a department of neurology learned to cope with many complex end-of-life situations. After a brief introduction to inter-team cooperation, clinical work of the mobile team with patients and families and its cooperation with the neurology team are presented. The specificity of supportive care in neurology is also analyzed. Two interdisciplinary and multi-professional tools - the Palliative Care Resource Group and the Ethics Consultation Group - are described, with their activities and their goals. The Palliative Care Resource Group is a specific entity whose identity lies at the crossroads between commonly recognized organizational units: clinic staff, clinical practice, ethical or organizational analysis groups (Balint, 1960), discussion groups (Rusznievski, 1999), training groups. It has several objectives: 1) create a robust conceptual environment enabling the pursuit of palliative care practices without relying on the empty paradigm of stereotypical actions; if suffering cannot be avoided, psychic development and transformation can be promoted; 2) attempt to prevent caregiver burnout; 3) help support and strengthen the collective dimension of the team, learning a mode of care which goes beyond the execution of coded actions; 4) enhance the primary dimension of care, i.e. taking care, especially in clinical situations where conventional wisdom declares that "nothing more can be done."; 5) promote group work so new ideas arising from the different teams influence the behavior of all caregivers. The Ethics Consultation Group organizes its work in several steps. The first step is discernment, clearly identifying the question at hand with the clinical staff. This is followed by a consultation between the clinical team, the patient, the family and the referring physician to arrive at a motivated decision, respecting the competent patient's opinion. The final step is an evaluation of the decision and its consequences. The Ethical Consultation Group, which meets at a scheduled time at a set place, unites the different members of the neurology and palliative care teams who come to a common decision. These specific moments have an important impact on team cohesion, creating a common culture and a convergence of individual representations about making difficult decisions. Specific clinical cases are described to illustrate some of the difficulties encountered in palliative care decision-making. These cases provide insight about the decision to create a palliative care gastrostomy for a man with progressive supranuclear palsy, the suffering experienced by a medical team caring for a young woman with Creutzfeldt-Jacob encephalopathy, or a woman's experience with the post-stroke life-and-death seesaw. Theoretical divisions, illustrated with clinical stories, can be useful touchstones for neurology teams. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

Research highlights from the UIC/NIH Center for Botanical Dietary Supplements Research for Women’s Health: Black cohosh from the field to the clinic

PubMed Central

Farnsworth, Norman R; Mahady, Gail B.

2009-01-01

In 1999, the Department of Medicinal Chemistry and Pharmacognosy at the College of Pharmacy, University of Illinois (UIC) at Chicago was funded to establish a Botanical Dietary Supplements Research Center from the National Institutes of Health (NIH). The emphasis of the UIC/NIH Center for Botanical Dietary Supplements Research (CBDSR) is botanical dietary supplements (BDS) for women's health. Center’s research has focused on BDS that may improve women's health and quality of life, specifically in the areas of menopause, premenstrual syndrome, and persistent urinary tract infections. Center investigators have overcome many challenges associated with botanical dietary supplements research, including acquiring and identifying plant species for investigation, isolating and identifying active constituents, elucidating the mechanisms of action of these botanicals, and conducting phase I and phase II clinical studies. Black cohosh [Actaea racemosa L. (Ranunculaceae)] has been used as a model to illustrate the steps involved in taking a botanical dietary supplement from the field, all the way to clinical trials. Bioassays are described that were necessary to elucidate the pertinent biological studies of plant extracts and their mechanisms of action. The Center has used an innovative multidisciplinary approach to this type of research, and thus has been very successful in fulfilling its specific aims. PMID:20161501

Androgen actions on endothelium functions and cardiovascular diseases

PubMed Central

Cai, Jing-Jing; Wen, Juan; Jiang, Wei-Hong; Lin, Jian; Hong, Yuan; Zhu, Yuan-Shan

2016-01-01

The roles of androgens on cardiovascular physiology and pathophysiology are controversial as both beneficial and detrimental effects have been reported. Although the reasons for this discrepancy are unclear, multiple factors such as genetic and epigenetic variation, sex-specificity, hormone interactions, drug preparation and route of administration may contribute. Recently, growing evidence suggests that androgens exhibit beneficial effects on cardiovascular function though the mechanism remains to be elucidated. Endothelial cells (ECs) which line the interior surface of blood vessels are distributed throughout the circulatory system, and play a crucial role in cardiovascular function. Endothelial progenitor cells (EPCs) are considered an indispensable element for the reconstitution and maintenance of an intact endothelial layer. Endothelial dysfunction is regarded as an initiating step in development of atherosclerosis and cardiovascular diseases. The modulation of endothelial functions by androgens through either genomic or nongenomic signal pathways is one possible mechanism by which androgens act on the cardiovascular system. Obtaining insight into the mechanisms by which androgens affect EC and EPC functions will allow us to determine whether androgens possess beneficial effects on the cardiovascular system. This in turn may be critical in the prevention and therapy of cardiovascular diseases. This article seeks to review recent progress in androgen regulation of endothelial function, the sex-specificity of androgen actions, and its clinical applications in the cardiovascular system. PMID:27168746

Effective Strategies for Monitoring and Regulating Chemical Mixtures and Contaminants Sharing Pathways of Toxicity

PubMed Central

Venkatesan, Arjun K.; Halden, Rolf U.

2015-01-01

Traditionally, hazardous chemicals have been regulated in the U.S. on a one-by-one basis, an approach that is slow, expensive and can be inefficient, as illustrated by a decades-long succession of replacing one type of organohalogen flame retardants (OHFRs) with another one, without addressing the root cause of toxicity and associated public health threats posed. The present article expounds on the need for efficient monitoring strategies and pragmatic steps in reducing environmental pollution and adverse human health impacts. A promising approach is to combine specific bioassays with state-of-the-art chemical screening to identify chemicals and chemical mixtures sharing specific modes of action (MOAs) and pathways of toxicity (PoTs). This approach could be used to identify and regulate hazardous chemicals as classes or compound families, featuring similar biological end-points, such as endocrine disruption and mutagenicity. Opportunities and potential obstacles of implementing this approach are discussed. PMID:26343697

Elicitation of cognitions related to HIV risk behaviors in persons with mental illnesses: implications for prevention.

PubMed

Tennille, Julie; Solomon, Phyllis; Fishbein, Martin; Blank, Michael

2009-01-01

An important step in research using the Theory of Reasoned Action and Theory of Planned Behavior (TRA/TPB) is conducting an elicitation process to identify topic and population specific cognitions. This study explored HIV risk behaviors in persons with mental illnesses and introduces findings from focus groups conducted during the development phase of an HIV primary and secondary prevention intervention study. Researchers held four focus groups with persons with mental illnesses focused on HIV risks and condom use. Participants discussed sexual side effects of psychotropic medications as a potential cause of both medication non-adherence and HIV risk behaviors. The intersection of these two issues is specific to this population. We conclude with the recommendation that HIV primary and secondary prevention intervention for persons with mental illnesses must incorporate the promotion of healthy sexuality, including attention to sexual side effects of psychotropic medications.

Eudicot plant-specific sphingolipids determine host selectivity of microbial NLP cytolysins.

PubMed

Lenarčič, Tea; Albert, Isabell; Böhm, Hannah; Hodnik, Vesna; Pirc, Katja; Zavec, Apolonija B; Podobnik, Marjetka; Pahovnik, David; Žagar, Ema; Pruitt, Rory; Greimel, Peter; Yamaji-Hasegawa, Akiko; Kobayashi, Toshihide; Zienkiewicz, Agnieszka; Gömann, Jasmin; Mortimer, Jenny C; Fang, Lin; Mamode-Cassim, Adiilah; Deleu, Magali; Lins, Laurence; Oecking, Claudia; Feussner, Ivo; Mongrand, Sébastien; Anderluh, Gregor; Nürnberger, Thorsten

2017-12-15

Necrosis and ethylene-inducing peptide 1-like (NLP) proteins constitute a superfamily of proteins produced by plant pathogenic bacteria, fungi, and oomycetes. Many NLPs are cytotoxins that facilitate microbial infection of eudicot, but not of monocot plants. Here, we report glycosylinositol phosphorylceramide (GIPC) sphingolipids as NLP toxin receptors. Plant mutants with altered GIPC composition were more resistant to NLP toxins. Binding studies and x-ray crystallography showed that NLPs form complexes with terminal monomeric hexose moieties of GIPCs that result in conformational changes within the toxin. Insensitivity to NLP cytolysins of monocot plants may be explained by the length of the GIPC head group and the architecture of the NLP sugar-binding site. We unveil early steps in NLP cytolysin action that determine plant clade-specific toxin selectivity. Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

[Management by objectives: an experience by transfusion and immunology service in Rabat].

PubMed

Essakalli, M; Atouf, O; Ouadghiri, S; Bouayad, A; Drissi, A; Sbain, K; Sakri, L; Benseffaj, N; Brick, C

2013-09-01

The management by objectives method has become highly used in health management. In this context, the blood transfusion and haemovigilance service has been chosen for a pilot study by the Head Department of the Ibn Sina Hospital in Rabat. This study was conducted from 2009 to 2011, in four steps. The first one consisted in preparing human resources (information and training), identifying the strengths and weaknesses of the service and the identification and classification of the service's users. The second step was the elaboration of the terms of the contract, which helped to determine two main strategic objectives: to strengthen the activities of the service and move towards the "status of reference." Each strategic objective had been declined in operational objectives, then in actions and the means required for the implementation of each action. The third step was the implementation of each action (service, head department) so as to comply with the terms of the contract as well as to meet the deadlines. Based on assessment committees, the last step consisted in the evaluation process. This evaluation was performed using monitoring indicators and showed that management by objectives enabled the Service to reach the "clinical governance level", to optimize its human and financial resources and to reach the level of "national laboratory of reference in histocompatibility". The scope of this paper is to describe the four steps of this pilot study and to explain the usefulness of the management by objectives method in health management. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

Identification and validation nucleolin as a target of curcumol in nasopharyngeal carcinoma cells.

PubMed

Wang, Juan; Wu, Jiacai; Li, Xumei; Liu, Haowei; Qin, Jianli; Bai, Zhun; Chi, Bixia; Chen, Xu

2018-06-30

Identification of the specific protein target(s) of a drug is a critical step in unraveling its mechanisms of action (MOA) in many natural products. Curcumol, isolated from well known Chinese medicinal plant Curcuma zedoary, has been shown to possess multiple biological activities. It can inhibit nasopharyngeal carcinoma (NPC) proliferation and induce apoptosis, but its target protein(s) in NPC cells remains unclear. In this study, we employed a mass spectrometry-based chemical proteomics approach reveal the possible protein targets of curcumol in NPC cells. Cellular thermal shift assay (CETSA), molecular docking and cell-based assay was used to validate the binding interactions. Chemical proteomics capturing uncovered that NCL is a target of curcumol in NPC cells, Molecular docking showed that curcumol bound to NCL with an -7.8 kcal/mol binding free energy. Cell function analysis found that curcumol's treatment leads to a degradation of NCL in NPC cells, and it showed slight effects on NP69 cells. In conclusion, our results providing evidences that NCL is a target protein of curcumol. We revealed that the anti-cancer effects of curcumol in NPC cells are mediated, at least in part, by NCL inhibition. Many natural products showed high bioactivity, while their mechanisms of action (MOA) are very poor or completely missed. Understanding the MOA of natural drugs can thoroughly exploit their therapeutic potential and minimize their adverse side effects. Identification of the specific protein target(s) of a drug is a critical step in unraveling its MOA. Compound-centric chemical proteomics is a classic chemical proteomics approach which integrates chemical synthesis with cell biology and mass spectrometry (MS) to identify protein targets of natural products determine the drug mechanism of action, describe its toxicity, and figure out the possible cause of off-target. It is an affinity-based chemical proteomics method to identify small molecule-protein interactions through affinity chromatography approach coupled with mass spectrometry, has been conventionally used to identify target proteins and has yielded good results. Curcumol, has shown effective inhibition on Nasopharyngeal Carcinoma (NPC) Cells, interacted with NCL and then initiated the anti-tumor biological effect. This research demonstrated the effectiveness of chemical proteomics approaches in natural drugs molecular target identification, revealing and understanding of the novel mechanism of actions of curcumol is crucial for cancer prevention and treatment in nasopharynx cancer. Copyright © 2018 Elsevier B.V. All rights reserved.

Poison Center Network Act

THOMAS, 113th Congress

Sen. Murray, Patty [D-WA

2013-11-18

Senate - 12/19/2013 Placed on Senate Legislative Calendar under General Orders. Calendar No. 281. (All Actions) Notes: For further action, see H.R.3527, which became Public Law 113-77 on 1/24/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

National Flood Insurance Program Extension Act of 2010

THOMAS, 111th Congress

Rep. Pomeroy, Earl [D-ND-At Large

2010-03-04

House - 03/04/2010 Referred to the House Committee on Financial Services. (All Actions) Notes: For further action, see H.R.5569, which became Public Law 111-196 on 7/2/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Transition Assistance Advisor Act of 2012

THOMAS, 112th Congress

Sen. Casey, Robert P., Jr. [D-PA

2012-06-28

Senate - 06/28/2012 Read twice and referred to the Committee on Armed Services. (All Actions) Notes: For further action, see H.R.4310, which became Public Law 112-239 on 1/2/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Mount Stevens and Ted Stevens Icefield Designation Act

THOMAS, 111th Congress

Rep. Young, Don [R-AK-At Large

2010-09-23

House - 09/23/2010 Referred to the House Committee on Natural Resources. (All Actions) Notes: For further action, see S.3802, which became Public Law 111-284 on 10/18/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Water Heater Rating Improvement Act of 2011

THOMAS, 112th Congress

Rep. Cooper, Jim [D-TN-5

2011-01-26

House - 02/09/2011 Referred to the Subcommittee on Energy and Power. (All Actions) Notes: For further action, see H.R.6582, which became Public Law 112-210 on 12/18/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Pedestrian Safety Enhancement Act of 2009

THOMAS, 111th Congress

Rep. Towns, Edolphus [D-NY-10

2009-01-28

House - 02/02/2009 Referred to the Subcommittee on Commerce, Trade and Consumer Protection. (All Actions) Notes: For further action, see S.841, which became Public Law 111-373 on 1/4/2011. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Protect our Kids Act of 2012

THOMAS, 112th Congress

Sen. Baucus, Max [D-MT

2012-12-21

Senate - 12/21/2012 Read twice and referred to the Committee on Finance. (All Actions) Notes: For further action, see H.R.6655, which became Public Law 112-275 on 1/14/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Veterans' Compensation Cost-of-Living Adjustment Act of 2010

THOMAS, 111th Congress

Sen. Akaka, Daniel K. [D-HI

2010-03-11

Senate - 09/22/2010 Returned to the Calendar. Calendar No. 550. (All Actions) Notes: For further action, see H.R.4667, which became Public Law 111-247 on 9/30/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

American Heroes COLA Act of 2014

THOMAS, 113th Congress

Rep. Runyan, Jon [R-NJ-3

2014-02-26

House - 03/07/2014 Referred to the Subcommittee on Disability Assistance and Memorial Affairs. (All Actions) Notes: For further action, see S.2258, which became Public Law 113-181 on 9/26/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Coast Guard and Maritime Transportation Act of 2012

THOMAS, 112th Congress

Rep. LoBiondo, Frank A. [R-NJ-2

2012-06-01

House - 06/07/2012 Subcommittee on Coast Guard and Maritime Transportation Discharged. (All Actions) Notes: For further action, see H.R.2838, which became Public Law 112-213 on 12/20/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Chesapeake Bay Accountability and Recovery Act of 2013

THOMAS, 113th Congress

Rep. Wittman, Robert J. [R-VA-1

2013-02-14

House - 05/19/2014 Placed on the Union Calendar, Calendar No. 335. (All Actions) Notes: For further action, see S.1000, which became Public Law 113-273 on 12/18/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Small Business Job Creation Act of 2010

THOMAS, 111th Congress

Sen. Snowe, Olympia J. [R-ME

2010-03-10

Senate - 03/10/2010 Read twice and referred to the Committee on Finance. (All Actions) Notes: For further action, see H.R.5297, which became Public Law 111-240 on 9/27/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

National Aeronautics and Space Administration Authorization Act of 2010

THOMAS, 111th Congress

Rep. Gordon, Bart [D-TN-6

2010-07-20

House - 07/28/2010 Placed on the Union Calendar, Calendar No. 333. (All Actions) Notes: For further action, see S.3729, which became Public Law 111-267 on 10/11/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Supplemental Appropriations Act, 2009

THOMAS, 111th Congress

Sen. Inouye, Daniel K. [D-HI

2009-05-14

Senate - 05/14/2009 Placed on Senate Legislative Calendar under General Orders. Calendar No. 62. (All Actions) Notes: For further action, see H.R.2346, which became Public Law 111-32 on 6/24/2009. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Kate Puzey Peace Corps Volunteer Protection Act of 2011

THOMAS, 112th Congress

Rep. Poe, Ted [R-TX-2

2011-06-23

House - 09/21/2011 Ordered to be Reported by Unanimous Consent. (All Actions) Notes: For further action, see S.1280, which became Public Law 112-57 on 11/21/2011. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Over-the-Counter Derivatives Markets Act of 2009

THOMAS, 111th Congress

Rep. Frank, Barney [D-MA-4

2009-10-13

House - 10/21/2009 Ordered to be Reported by Voice Vote. (All Actions) Notes: For further action, see H.R.4173, which became Public Law 111-203 on 7/21/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Protecting Children From Internet Pornographers Act of 2011

THOMAS, 112th Congress

Rep. Smith, Lamar [R-TX-21

2011-05-25

House - 12/16/2011 Placed on the Union Calendar, Calendar No. 224. (All Actions) Notes: For further action, see H.R.6063, which became Public Law 112-206 on 12/7/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Child Protection Act of 2012

THOMAS, 112th Congress

Sen. Blumenthal, Richard [D-CT

2012-07-30

Senate - 07/30/2012 Read twice and referred to the Committee on the Judiciary. (All Actions) Notes: For further action, see H.R.6063, which became Public Law 112-206 on 12/7/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Regulated Investment Company Modernization Act of 2010

THOMAS, 111th Congress

Sen. Bingaman, Jeff [D-NM

2010-11-17

Senate - 11/17/2010 Read twice and referred to the Committee on Finance. (All Actions) Notes: For further action, see H.R.4337, which became Public Law 111-325 on 12/22/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Post-9/11 Veterans Educational Assistance Improvements Act of 2010

THOMAS, 111th Congress

Rep. Minnick, Walter [D-ID-1

2010-07-29

House - 07/30/2010 Referred to the Subcommittee on Economic Opportunity. (All Actions) Notes: For further action, see S.3447, which became Public Law 111-377 on 1/4/2011. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Black Hills Cemetery Act

THOMAS, 113th Congress

Sen. Thune, John [R-SD

2013-03-05

Senate - 06/27/2013 Placed on Senate Legislative Calendar under General Orders. Calendar No. 117. (All Actions) Notes: For further action, see H.R.291, which became Public Law 113-131 on 7/25/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Columbine-Hondo Wilderness Act

THOMAS, 113th Congress

Sen. Udall, Tom [D-NM

2013-04-22

Senate - 12/10/2014 Placed on Senate Legislative Calendar under General Orders. Calendar No. 631. (All Actions) Notes: For further action, see H.R.3979, which became Public Law 113-291 on 12/19/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Helium Stewardship Act of 2013

THOMAS, 113th Congress

Sen. Wyden, Ron [D-OR

2013-04-23

Senate - 07/29/2013 Placed on Senate Legislative Calendar under General Orders. Calendar No. 152. (All Actions) Notes: For further action, see H.R.527, which became Public Law 113-40 on 10/2/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Shark Conservation Act of 2009

THOMAS, 111th Congress

Sen. Kerry, John F. [D-MA

2009-04-22

Senate - 02/04/2010 Placed on Senate Legislative Calendar under General Orders. Calendar No. 270. (All Actions) Notes: For further action, see H.R.81, which became Public Law 111-348 on 1/4/2011. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Energy and Commerce Recovery and Reinvestment Act

THOMAS, 111th Congress

Rep. Waxman, Henry A. [D-CA-30

2009-01-22

House - 01/27/2009 Placed on the Union Calendar, Calendar No. 3. (All Actions) Notes: For further action, see H.R.1, which became Public Law 111-5 on 2/17/2009. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

CROWDFUND Act

THOMAS, 112th Congress

Sen. Merkley, Jeff [D-OR

2012-03-13

Senate - 03/13/2012 Read twice and referred to the Committee on Banking, Housing, and Urban Affairs. (All Actions) Notes: For further action, see H.R.3606, which became Public Law 112-106 on 4/5/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Allowing Qualified Local Employees to Serve Act

THOMAS, 112th Congress

Rep. Nugent, Richard B. [R-FL-5

2012-03-08

House - 03/08/2012 Referred to the House Committee on Oversight and Government Reform. (All Actions) Notes: For further action, see S.2170, which became Public Law 112-230 on 12/28/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Sabinoso Wilderness Act of 2009

THOMAS, 111th Congress

Rep. Lujan, Ben Ray [D-NM-3

2009-02-09

House - 02/12/2009 Referred to the Subcommittee on National Parks, Forests and Public Lands. (All Actions) Notes: For further action, see H.R.146, which became Public Law 111-11 on 3/30/2009. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Sugar Loaf Fire Protection District Land Exchange Act

THOMAS, 112th Congress

Rep. Polis, Jared [D-CO-2

2011-02-10

House - 07/20/2011 Placed on the Union Calendar, Calendar No. 106. (All Actions) Notes: For further action, see S.278, which became Public Law 112-79 on 12/23/2011. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Cabin Fee Act of 2013

THOMAS, 113th Congress

Sen. Tester, Jon [D-MT

2013-07-23

Senate - 05/22/2014 Placed on Senate Legislative Calendar under General Orders. Calendar No. 397. (All Actions) Notes: For further action, see H.R.3979, which became Public Law 113-291 on 12/19/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

A bill to require the Commodity Futures Trading commission to take certain emergency action to eliminate excessive speculation in energy markets.

THOMAS, 113th Congress

Sen. Sanders, Bernard [I-VT

2014-06-26

Senate - 06/26/2014 Read twice and referred to the Committee on Agriculture, Nutrition, and Forestry. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Sleeping Bear Dunes National Lakeshore Conservation and Recreation Act

THOMAS, 113th Congress

Rep. Benishek, Dan [R-MI-1

2013-01-04

House - 02/28/2014 Placed on the Union Calendar, Calendar No. 272. (All Actions) Notes: For further action, see S.23, which became Public Law 113-87 on 3/13/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Prescription Drug Labeling Promotion Act of 2012

THOMAS, 112th Congress

Rep. Markey, Edward J. [D-MA-7

2012-02-24

House - 02/24/2012 Referred to the House Committee on Energy and Commerce. (All Actions) Notes: For further action, see S.3187, which became Public Law 112-144 on 7/9/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Veterans' Traumatic Brain Injury Rehabilitative Services' Improvements Act of 2011

THOMAS, 112th Congress

Sen. Boozman, John [R-AR

2011-05-11

Senate - 06/08/2011 Committee on Veterans' Affairs. Hearings held. (All Actions) Notes: For further action, see H.R.1627, which became Public Law 112-154 on 8/6/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Fallen Heroes of 9/11 Act

THOMAS, 112th Congress

Sen. Casey, Robert P., Jr. [D-PA

2011-06-21

House - 09/12/2011 Referred to the House Committee on Financial Services. (All Actions) Notes: For further action, see H.R.3421, which became Public Law 112-76 on 12/23/2011. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Fallen Heroes of 9/11 Act

THOMAS, 112th Congress

Rep. Shuster, Bill [R-PA-9

2011-09-07

House - 10/04/2011 Referred to the Subcommittee on Domestic Monetary Policy and Technology. (All Actions) Notes: For further action, see H.R.3421, which became Public Law 112-76 on 12/23/2011. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

A bill to award the Congressional Gold Medal to Shimon Peres.

THOMAS, 113th Congress

Sen. Ayotte, Kelly [R-NH

2013-08-01

House - 03/14/2014 Held at the desk. (All Actions) Notes: For further action, see H.R.2939, which became Public Law 113-114 on 6/9/2014. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Stem Cell Therapeutic and Research Reauthorization Act of 2010

THOMAS, 111th Congress

Rep. Young, C. W. Bill [R-FL-10

2010-08-09

House - 09/28/2010 Placed on the Union Calendar, Calendar No. 383. (All Actions) Notes: For further action, see S.3751, which became Public Law 111-264 on 10/8/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Crow Tribe Water Rights Settlement Act of 2009

THOMAS, 111th Congress

Rep. Rehberg, Denny [R-MT-At Large

2009-02-04

House - 02/09/2009 Referred to the Subcommittee on Water and Power. (All Actions) Notes: For further action, see H.R.4783, which became Public Law 111-291 on 12/8/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Private Fund Investment Advisers Registration Act of 2009

THOMAS, 111th Congress

Rep. Kanjorski, Paul E. [D-PA-11

2009-10-15

House - 12/17/2010 Placed on the Union Calendar, Calendar No. 407. (All Actions) Notes: For further action, see H.R.4173, which became Public Law 111-203 on 7/21/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Naval Vessel Transfer Act of 2013

THOMAS, 113th Congress

Sen. Coats, Daniel [R-IN

2013-02-26

Senate - 02/26/2013 Read twice and referred to the Committee on Foreign Relations. (All Actions) Notes: For further action, see S.1683, which became Public Law 113-276 on 12/18/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Hatch Act Modernization Act of 2012

THOMAS, 112th Congress

Rep. Cummings, Elijah E. [D-MD-7

2012-03-07

House - 03/07/2012 Referred to the House Committee on Oversight and Government Reform. (All Actions) Notes: For further action, see S.2170, which became Public Law 112-230 on 12/28/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Sequestration Transparency Act of 2012

THOMAS, 112th Congress

Sen. Thune, John [R-SD

2012-05-23

Senate - 05/23/2012 Read twice and referred to the Committee on the Budget. (All Actions) Notes: For further action, see H.R.5872, which became Public Law 112-155 on 8/7/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Haqqani Network Terrorist Designation Act of 2012

THOMAS, 112th Congress

Rep. Rogers, Mike J. [R-MI-8

2012-06-27

House - 07/11/2012 Referred to the Subcommittee on Crime, Terrorism, and Homeland Security. (All Actions) Notes: For further action, see S.1959, which became Public Law 112-168 on 8/10/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Combating Autism Reauthorization Act

THOMAS, 112th Congress

Sen. Menendez, Robert [D-NJ

2011-05-26

Senate - 09/12/2011 Placed on Senate Legislative Calendar under General Orders. Calendar No. 163. (All Actions) Notes: For further action, see H.R.2005, which became Public Law 112-32 on 9/30/2011. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Kalaupapa Memorial Act of 2009

THOMAS, 111th Congress

Rep. Hirono, Mazie K. [D-HI-2

2009-01-09

House - 02/04/2009 Referred to the Subcommittee on National Parks, Forests and Public Lands. (All Actions) Notes: For further action, see H.R.146, which became Public Law 111-11 on 3/30/2009. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Small Business Export Enhancement Act of 2010

THOMAS, 111th Congress

Rep. Dahlkemper, Kathleen A. [D-PA-3

2010-07-22

House - 07/22/2010 Referred to the House Committee on Small Business. (All Actions) Notes: For further action, see H.R.5297, which became Public Law 111-240 on 9/27/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Trade Adjustment Assistance Extension Act of 2010

THOMAS, 111th Congress

Sen. Brown, Sherrod [D-OH

2010-12-22

Senate - 12/22/2010 Read twice and referred to the Committee on Finance. (All Actions) Notes: For further action, see H.R.6517, which became Public Law 111-344 on 12/29/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Arizona National Scenic Trail Act

THOMAS, 111th Congress

Rep. Giffords, Gabrielle [D-AZ-8

2009-01-15

House - 02/04/2009 Referred to the Subcommittee on National Parks, Forests and Public Lands. (All Actions) Notes: For further action, see H.R.146, which became Public Law 111-11 on 3/30/2009. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Servicemembers' Telemedicine and E-Health Portability Act of 2011

THOMAS, 112th Congress

Rep. Thompson, Glenn [R-PA-5

2011-05-11

House - 05/25/2011 Referred to the Subcommittee on Health. (All Actions) Notes: For further action, see H.R.1540, which became Public Law 112-81 on 12/31/2011. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

To modify a land grant patent issued by the Secretary of the Interior.

THOMAS, 112th Congress

Rep. Benishek, Dan [R-MI-1

2011-11-14

House - 01/24/2012 Subcommittee Hearings Held. (All Actions) Notes: For further action, see S.404, which became Public Law 112-137 on 6/27/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Divisional Realignment Act of 2012

THOMAS, 112th Congress

Sen. McCaskill, Claire [D-MO

2012-06-14

Senate - 06/14/2012 Read twice and referred to the Committee on the Judiciary. (All Actions) Notes: For further action, see H.R.5512, which became Public Law 112-188 on 10/5/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Creating American Jobs Through Foreign Capital Investment Act

THOMAS, 112th Congress

Rep. Larsen, Rick [D-WA-2

2011-09-20

House - 09/23/2011 Referred to the Subcommittee on Immigration Policy and Enforcement. (All Actions) Notes: For further action, see S.3245, which became Public Law 112-176 on 9/28/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Ultralight Aircraft Smuggling Prevention Act of 2011

THOMAS, 112th Congress

Sen. Udall, Tom [D-NM

2011-08-02

Senate - 08/02/2011 Read twice and referred to the Committee on Finance. (All Actions) Notes: For further action, see H.R.3801, which became Public Law 112-93 on 2/10/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Helping Heroes Fly Act

THOMAS, 113th Congress

Sen. Pryor, Mark L. [D-AR

2013-07-31

Senate - 07/31/2013 Read twice and referred to the Committee on Commerce, Science, and Transportation. (All Actions) Notes: For further action, see H.R.1344, which became Public Law 113-27 on 8/9/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Helping Heroes Fly Act

THOMAS, 113th Congress

Sen. Pryor, Mark L. [D-AR

2013-07-25

Senate - 07/25/2013 Read twice and referred to the Committee on Commerce, Science, and Transportation. (All Actions) Notes: For further action, see H.R.1344, which became Public Law 113-27 on 8/9/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

District of Columbia Financial Efficiency Act of 2013

THOMAS, 113th Congress

Rep. Issa, Darrell E. [R-CA-49

2013-07-23

House - 07/24/2013 Ordered to be Reported by Unanimous Consent. (All Actions) Notes: For further action, see H.R.3343, which became Public Law 113-71 on 12/26/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

State Small Business Credit Initiative Act of 2010

THOMAS, 111th Congress

Rep. Peters, Gary C. [D-MI-9

2010-05-13

House - 05/13/2010 Referred to the House Committee on Financial Services. (All Actions) Notes: For further action, see H.R.5297, which became Public Law 111-240 on 9/27/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Intelligence Authorization Act for Fiscal Year 2015

THOMAS, 113th Congress

Rep. Rogers, Mike J. [R-MI-8

2014-05-15

House - 05/15/2014 Referred to the House Committee on Intelligence (Permanent Select). (All Actions) Notes: For further action, see H.R.4681, which became Public Law 113-293 on 12/19/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Bountiful City Land Consolidation Act

THOMAS, 111th Congress

Rep. Bishop, Rob [R-UT-1

2009-01-16

House - 02/04/2009 Referred to the Subcommittee on National Parks, Forests and Public Lands. (All Actions) Notes: For further action, see H.R.146, which became Public Law 111-11 on 3/30/2009. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Small Business Penalty Relief Act of 2009

THOMAS, 111th Congress

Sen. Baucus, Max [D-MT

2009-11-16

Senate - 11/16/2009 Read twice and referred to the Committee on Finance. (All Actions) Notes: For further action, see H.R.5297, which became Public Law 111-240 on 9/27/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Small Business Penalty Relief Act of 2009

THOMAS, 111th Congress

Rep. Lewis, John [D-GA-5

2009-11-16

House - 11/16/2009 Referred to the House Committee on Ways and Means. (All Actions) Notes: For further action, see H.R.5297, which became Public Law 111-240 on 9/27/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Powering American Jobs Act of 2014

THOMAS, 113th Congress

Rep. Kelly, Mike [R-PA-3

2014-12-01

House - 12/01/2014 Referred to the House Committee on Ways and Means. (All Actions) Notes: For further action, see H.R.5771, which became Public Law 113-295 on 12/19/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Division Realignment Act of 2013

THOMAS, 113th Congress

Rep. Thompson, Bennie G. [D-MS-2

2013-07-31

House - 09/13/2013 Referred to the Subcommittee on Courts, Intellectual Property, and the Internet. (All Actions) Notes: For further action, see H.R.2871, which became Public Law 113-61 on 12/20/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Subcontracting Transparency and Reliability Act of 2012

THOMAS, 112th Congress

Rep. Mulvaney, Mick [R-SC-5

2012-02-02

House - 12/27/2012 Placed on the Union Calendar, Calendar No. 534. (All Actions) Notes: For further action, see H.R.4310, which became Public Law 112-239 on 1/2/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Tax Technical Corrections Act of 2014

THOMAS, 113th Congress

Rep. Camp, Dave [R-MI-4

2014-09-18

House - 09/18/2014 Referred to the House Committee on Ways and Means. (All Actions) Notes: For further action, see H.R.5771, which became Public Law 113-295 on 12/19/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation: