Influences of Prerequisite Knowledge on Inferencing in Literature.

ERIC Educational Resources Information Center

Stander, Aaron C.

New information about reading comprehension (specifically schema theory) was applied to the teaching of literature in a study involving 33 high school students enrolled in two American literature classes. In particular, the study examined the ways in which knowledge of background information about a work could influence students' comprehension of…

78 FR 48540 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-08

... collection. Background: Information to be collected will focus on pilot, controller, or vehicle driver practices and/or feedback on specific runway safety initiatives, such as training programs, Runway Safety... incursions. Respondents: An estimated 8,900 pilots, aircraft support vehicle drivers, airport/airfield...

Aggression, Social Cognitions, Anger and Sadness in Bullies and Victims

ERIC Educational Resources Information Center

Camodeca, Marina; Goossens, Frits A.

2005-01-01

Background: The present study aimed to investigate children's social information processing (SIP) and emotions in the bullying situation, taking into account reactive and proactive aggression. More specifically, we investigated the way in which children interpret social information, which goals they select, how they evaluate their responses and…

GUIDE FOR SOCIAL STUDIES AND SCIENCE-HEALTH, FIRST YEAR. JUNIOR HIGH SCHOOL SPECIAL CURRICULUM.

ERIC Educational Resources Information Center

STINCHCOMB, KOMA D.; AND OTHERS

THIS CURRICULUM GUIDE FOR JUNIOR HIGH EDUCABLE MENTALLY HANDICAPPED STUDENTS PROVIDES INFORMATION ON TEACHING PROCEDURES, SUGGESTIONS FOR PLANNING SUPPLEMENTAL UNITS, TYPES OF LESSONS, AND EVALUATION. INDIVIDUAL UNITS INCLUDE THE INFORMATION CONTENT, SUGGESTIONS FOR BACKGROUND STUDY, SPECIFIC TEACHING PLANS, DISCUSSION QUESTIONS, ASSIGNMENTS,…

Information Needs to Support an Evaluation Process for Bureau of Indian Affairs Educational Programs.

ERIC Educational Resources Information Center

Jeffery, James R., Comp.

The purpose of this paper is to provide the Director of the Office of Education Programs with an instrument with which to develop an educational data base for providing information to evaluate the education programs of the Bureau of Indian Affairs (BIA). Some specific issues and questions are presented along with background information. BIA…

Characterizing Health Information for Different Target Audiences.

PubMed

Sun, Yueping; Hou, Zhen; Hou, Li; Li, Jiao

2015-01-01

Different groups of audiences in health care: health professionals and health consumers, each have different information needs. Health monographs targeting different audiences are created by leveraging readers' background knowledge. The NCI's Physician Data Query (PDQ®) Cancer Information Summaries provide parallel cancer information and education resources with different target audiences. In this paper, we used targeted audience-specific cancer information PDQs to measure characteristic differences on the element level between audiences. In addition, we compared vocabulary coverage. Results show a significant difference between the professional and patient version of cancer monographs in both content organization and vocabulary. This study provides a new view to assess targeted audience-specific health information, and helps editors to improve the quality and readability of health information.

Exploration of a "Double-Jeopardy" Hypothesis within Working Memory Profiles for Children with Specific Language Impairment

ERIC Educational Resources Information Center

Briscoe, J.; Rankin, P. M.

2009-01-01

Background: Children with specific language impairment (SLI) often experience difficulties in the recall and repetition of verbal information. Archibald and Gathercole (2006) suggested that children with SLI are vulnerable across two separate components of a tripartite model of working memory (Baddeley and Hitch 1974). However, the hierarchical…

Using Niche-Market Magazines to Teach Audience

ERIC Educational Resources Information Center

Tichenor, Stuart

2006-01-01

In technical writing classes, audience is one of the most important concepts. Technical writing is typically written to a specific audience for a specific purpose. In addition, as audiences change, so must the way a document is written. An audience's lack of knowledge in a technical area, for example, would require more background information or…

Issues of War Trauma and Working with Refugees. A Compilation of Resources.

ERIC Educational Resources Information Center

Somach, Susan D., Comp.

The Center for Applied Linguistics has compiled these resources on the subjects of war trauma and working with refugees to guide refugee service providers and classroom teachers. The materials include background information about trauma and posttraumatic stress disorder and specific information about problems of refugees and victims of war trauma.…

Adoption of Information and Communication Technologies (ICTs) by Agricultural Science and Extension Teachers in Abuja, Nigeria

ERIC Educational Resources Information Center

Alabi, Olugbenga Omotayo

2016-01-01

This study examined adoption of Information and Communication Technologies (ICTs) by agricultural science and extension teachers in Abuja, Nigeria. Specifically, the objectives are to: identify the background and demographic characteristics of agricultural science and extension teachers in the study area; examine the factors influencing adoption…

A National Survey of Mental Health Screening and Assessment Practices in Juvenile Correctional Facilities

ERIC Educational Resources Information Center

Swank, Jacqueline M.; Gagnon, Joseph C.

2017-01-01

Background: Mental health screening and assessment is crucial within juvenile correctional facilities (JC). However, limited information is available about the current screening and assessment procedures specifically within JC. Objective: The purpose of the current study was to obtain information about the mental health screening and assessment…

75 FR 21006 - Town Hall Discussion With the Director of the Center for Devices and Radiological Health and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-22

... Radiological Health (CDRH) fiscal year (FY) 2010 priorities. In addition, FDA is interested in engaging in... information and discuss issues of importance to the medical device industry. CDRH is specifically interested... through Friday. SUPPLEMENTARY INFORMATION: I. Background CDRH has announced four priority areas of...

Sentence Repetition: What Does the Task Measure?

ERIC Educational Resources Information Center

Polišenská, Kamila; Chiat, Shula; Roy, Penny

2015-01-01

Background: Sentence repetition is gaining increasing attention as a source of information about children's sentence-level abilities in clinical assessment, and as a clinical marker of specific language impairment. However, it is widely debated what the task is testing and therefore how informative it is. Aims: (1) To evaluate the effects of…

[The Impact of Immigrant Status on the Mode of Hospital Referral, Impression of Disease Severity and Length of Stay in Inpatient General Pediatric Care].

PubMed

Ullrich, Sebastian; Nesterko, Yuriy; Briel, Diana; Hiemisch, Andreas; Brähler, Elmar; Glaesmer, Heide

2017-08-10

Background National as well as international research often shows differences in health and health behavior between children and youth with and without migration background. It is also noted that there are differences in the use of health services depending on the migration background. Patients and Methods Data from 266 pediatric patients, regarding their hospitalization, general impression of health status and length of stay in a hospital, were analyzed depending on the migration background. Information on migration background and treatment-related data were obtained from the parents of the patient or from the hospital information system (SAP). 20.7% of patients (n=55) had a migration background. Results Migrants were hospitalized more often under a participation of the emergency room than non-migrants; also migrants showed a more severe illness picture. Regarding the number of diagnoses and length of stay as well as the distribution of the main diagnoses, no differences were found. Discussion Language barriers, culture-specific ideas about illness and insufficient knowledge of the German health care system were discussed as possible reasons to for the differences between migrants and non-migrants. Conclusion This study confirms already known differences in the use of health services by people with and without migration background. The results indicate worse health status in migrant patients compared to non-migrants by hospitalization. Future research with greater numbers of participants should specifically investigate on this point. © Georg Thieme Verlag KG Stuttgart · New York.

The Great Hydrometer Construction Contest!

ERIC Educational Resources Information Center

McGinnis, James Randy; Padilla, Michael J.

1991-01-01

The relationship between specific gravity, salinity, and density in brine solutions is investigated. Students construct hydrometers to reinforce concepts learned in oceanography. Background information, salt requirements for the unknowns, directions, and reproducible worksheets are included. (KR)

Background Investigations and Clearances

EPA Pesticide Factsheets

You may need to complete certain security forms and report for identity proofing and fingerprinting before you can begin work at EPA. The following document contain specific instructions and information to help guide you through the process:

Draft Site Treatment Plan (DSTP), Volumes I and II

DOE Office of Scientific and Technical Information (OSTI.GOV)

D`Amelio, J.

1994-08-30

Site Treatment Plans (STP) are required for facilities at which the DOE generates or stores mixed waste. This Draft Site Treatment Plan (DSTP) the second step in a three-phase process, identifies the currently preferred options for treating mixed waste at the Savannah River Site (SRS) or for developing treatment technologies where technologies do not exist or need modification. The DSTP reflects site-specific preferred options, developed with the state`s input and based on existing available information. To the extent possible, the DSTP identifies specific treatment facilities for treating the mixed waste and proposes schedules. Where the selection of specific treatment facilitiesmore » is not possible, schedules for alternative activities such as waste characterization and technology assessment are provided. All schedule and cost information presented is preliminary and is subject to change. The DSTP is comprised of two volumes: this Compliance Plan Volume and the Background Volume. This Compliance Plan Volume proposes overall schedules with target dates for achieving compliance with the land disposal restrictions (LDR) of RCRA and procedures for converting the target dates into milestones to be enforced under the Order. The more detailed discussion of the options contained in the Background Volume is provided for informational purposes only.« less

Ageing without hearing loss or cognitive impairment causes a decrease in speech intelligibility only in informational maskers.

PubMed

Rajan, R; Cainer, K E

2008-06-23

In most everyday settings, speech is heard in the presence of competing sounds and understanding speech requires skills in auditory streaming and segregation, followed by identification and recognition, of the attended signals. Ageing leads to difficulties in understanding speech in noisy backgrounds. In addition to age-related changes in hearing-related factors, cognitive factors also play a role but it is unclear to what extent these are generalized or modality-specific cognitive factors. We examined how ageing in normal-hearing decade age cohorts from 20 to 69 years affected discrimination of open-set speech in background noise. We used two types of sentences of similar structural and linguistic characteristics but different masking levels (i.e. differences in signal-to-noise ratios required for detection of sentences in a standard masker) so as to vary sentence demand, and two background maskers (one causing purely energetic masking effects and the other causing energetic and informational masking) to vary load conditions. There was a decline in performance (measured as speech reception thresholds for perception of sentences in noise) in the oldest cohort for both types of sentences, but only in the presence of the more demanding informational masker. We interpret these results to indicate a modality-specific decline in cognitive processing, likely a decrease in the ability to use acoustic and phonetic cues efficiently to segregate speech from background noise, in subjects aged >60.

Hellsgate Big Game Winter Range Wildlife Mitigation Site Specific Management Plan for the Hellsgate Project.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Berger, Matthew T.; Judd, Steven L.

This report contains a detailed site-specific management plan for the Hellsgate Winter Range Wildlife Mitigation Project. The report provides background information about the mitigation process, the review process, mitigation acquisitions, Habitat Evaluation Procedures (HEP) and mitigation crediting, current habitat conditions, desired future habitat conditions, restoration/enhancements efforts and maps.

Using Principles of Learning to Inform Language Therapy Design for Children with Specific Language Impairment

ERIC Educational Resources Information Center

Alt, Mary; Meyers, Christina; Ancharski, Alexandra

2012-01-01

Background: Language treatment for children with specific language impairment (SLI) often takes months to achieve moderate results. Interventions often do not incorporate the principles that are known to affect learning in unimpaired learners. Aims: To outline some key findings about learning in typical populations and to suggest a model of how…

Library Service Now in New York State: A Background Paper Prepared for the Governor's Commission on Libraries. Some People Say...

ERIC Educational Resources Information Center

Prentice, Ann E.; Connor, Jean L.

Prepared as a background paper for the Governor's Conference on Libraries in June 1978, this document presents a summary of what is known (or not known) about the library 'picture' in New York State. This picture is sketched in an overview, and then specific areas are colored in. Information on each type of library--school, public, academic,…

Supplier Assessment System (SAS)

NASA Technical Reports Server (NTRS)

Dietrich, Kristen

2016-01-01

Background: Sponsored by NASA Headquarters; Charter - provide information to assist the quality assurance community in evaluating and determining supplier risk; Comprehensive on-line repository of supplier information; Available to approved civil service personnel from all NASA Centers, other U.S. Government Agencies, Prime Contractors, and NASA direct support contractors; User access to specific data types or documents is controlled as needed.

Facial Electromyographic Responses to Emotional Information from Faces and Voices in Individuals with Pervasive Developmental Disorder

ERIC Educational Resources Information Center

Magnee, Maurice J. C. M.; de Gelder, Beatrice; van Engeland, Herman; Kemner, Chantal

2007-01-01

Background: Despite extensive research, it is still debated whether impairments in social skills of individuals with pervasive developmental disorder (PDD) are related to specific deficits in the early processing of emotional information. We aimed to test both automatic processing of facial affect as well as the integration of auditory and visual…

The information content of cosmic microwave background anisotropies

NASA Astrophysics Data System (ADS)

Scott, Douglas; Contreras, Dagoberto; Narimani, Ali; Ma, Yin-Zhe

2016-06-01

The cosmic microwave background (CMB) contains perturbations that are close to Gaussian and isotropic. This means that its information content, in the sense of the ability to constrain cosmological models, is closely related to the number of modes probed in CMB power spectra. Rather than making forecasts for specific experimental setups, here we take a more pedagogical approach and ask how much information we can extract from the CMB if we are only limited by sample variance. We show that, compared with temperature measurements, the addition of E-mode polarization doubles the number of modes available out to a fixed maximum multipole, provided that all of the TT, TE, and EE power spectra are measured. However, the situation in terms of constraints on particular parameters is more complicated, as we explain and illustrate graphically. We also discuss the enhancements in information that can come from adding B-mode polarization and gravitational lensing. We show how well one could ever determine the basic cosmological parameters from CMB data compared with what has been achieved with Planck, which has already probed a substantial fraction of the TT information. Lastly, we look at constraints on neutrino mass as a specific example of how lensing information improves future prospects beyond the current 6-parameter model.

The information content of cosmic microwave background anisotropies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scott, Douglas; Contreras, Dagoberto; Narimani, Ali

The cosmic microwave background (CMB) contains perturbations that are close to Gaussian and isotropic. This means that its information content, in the sense of the ability to constrain cosmological models, is closely related to the number of modes probed in CMB power spectra. Rather than making forecasts for specific experimental setups, here we take a more pedagogical approach and ask how much information we can extract from the CMB if we are only limited by sample variance. We show that, compared with temperature measurements, the addition of E -mode polarization doubles the number of modes available out to a fixedmore » maximum multipole, provided that all of the TT , TE , and EE power spectra are measured. However, the situation in terms of constraints on particular parameters is more complicated, as we explain and illustrate graphically. We also discuss the enhancements in information that can come from adding B -mode polarization and gravitational lensing. We show how well one could ever determine the basic cosmological parameters from CMB data compared with what has been achieved with Planck , which has already probed a substantial fraction of the TT information. Lastly, we look at constraints on neutrino mass as a specific example of how lensing information improves future prospects beyond the current 6-parameter model.« less

Understanding the Role of Context in the Interpretation of Complex Battlespace Intelligence

DTIC Science & Technology

2006-01-01

Level 2 Fusion)" that there remains a significant need for higher levels of information fusion such as those required for generic situation awareness ... information in a set of reports, 2) general background knowledge e.g., doctrine, techniques, practices) plus 4) known situation-specific information (e.g... aware that notwithstanding any other provision of law, no person shall be subject to a penalty for failing to comply with a collection of information

Computer Anxiety: How to Measure It?

ERIC Educational Resources Information Center

McPherson, Bill

1997-01-01

Provides an overview of five scales that are used to measure computer anxiety: Computer Anxiety Index, Computer Anxiety Scale, Computer Attitude Scale, Attitudes toward Computers, and Blombert-Erickson-Lowrey Computer Attitude Task. Includes background information and scale specifics. (JOW)

Preserving Flow Variability in Watershed Model Calibrations

EPA Science Inventory

Background/Question/Methods Although watershed modeling flow calibration techniques often emphasize a specific flow mode, ecological conditions that depend on flow-ecology relationships often emphasize a range of flow conditions. We used informal likelihood methods to investig...

Promoting Community Health Resources: Preferred Communication Strategies

USDA-ARS?s Scientific Manuscript database

Background: Community health promotion efforts involve communicating resource information to priority populations. Which communication strategies are most effective is largely unknown for specific populations. Objective: A random-dialed telephone survey was conducted to assess health resource comm...

Meta-Modeling: A Knowledge-Based Approach to Facilitating Model Construction and Reuse

NASA Technical Reports Server (NTRS)

Keller, Richard M.; Dungan, Jennifer L.

1997-01-01

In this paper, we introduce a new modeling approach called meta-modeling and illustrate its practical applicability to the construction of physically-based ecosystem process models. As a critical adjunct to modeling codes meta-modeling requires explicit specification of certain background information related to the construction and conceptual underpinnings of a model. This information formalizes the heretofore tacit relationship between the mathematical modeling code and the underlying real-world phenomena being investigated, and gives insight into the process by which the model was constructed. We show how the explicit availability of such information can make models more understandable and reusable and less subject to misinterpretation. In particular, background information enables potential users to better interpret an implemented ecosystem model without direct assistance from the model author. Additionally, we show how the discipline involved in specifying background information leads to improved management of model complexity and fewer implementation errors. We illustrate the meta-modeling approach in the context of the Scientists' Intelligent Graphical Modeling Assistant (SIGMA) a new model construction environment. As the user constructs a model using SIGMA the system adds appropriate background information that ties the executable model to the underlying physical phenomena under investigation. Not only does this information improve the understandability of the final model it also serves to reduce the overall time and programming expertise necessary to initially build and subsequently modify models. Furthermore, SIGMA's use of background knowledge helps eliminate coding errors resulting from scientific and dimensional inconsistencies that are otherwise difficult to avoid when building complex models. As a. demonstration of SIGMA's utility, the system was used to reimplement and extend a well-known forest ecosystem dynamics model: Forest-BGC.

Ethnicity-specific factors influencing childhood immunisation decisions among Black and Asian Minority Ethnic groups in the UK: a systematic review of qualitative research.

PubMed

Forster, Alice S; Rockliffe, Lauren; Chorley, Amanda J; Marlow, Laura A V; Bedford, Helen; Smith, Samuel G; Waller, Jo

2017-06-01

Uptake of some childhood immunisations in the UK is lower among those from some Black and Asian Minority Ethnic (BAME) backgrounds. This systematic review of qualitative research sought to understand the factors that are associated with ethnicity that influence the immunisation decisions of parents from BAME backgrounds living in the UK. Databases were searched on 2 December 2014 for studies published at any time using the terms 'UK' and 'vaccination' and 'qualitative methods' (and variations of these). Included articles comprised participants who were parents from BAME backgrounds. Thematic synthesis methods were used to develop descriptive and higher order themes. Themes specific to ethnicity and associated factors are reported. Eight papers were included in the review. Most participants were from Black (n=62) or Asian (n=38) backgrounds. Two ethnicity-related factors affected immunisation decisions. First, factors that are related to ethnicity itself (namely religion, upbringing and migration, and language) affected parents' perceived importance of immunisations, whether immunisations were permitted or culturally acceptable and their understanding of immunisation/the immunisation schedule. Second, perceived biological differences affected decision-making and demand for information. Factors related to ethnicity must be considered when seeking to understand immunisation decisions among parents from BAME backgrounds. Where appropriate and feasible, vaccination information should be targeted to address beliefs about ethnic differences held by some individuals from some BAME backgrounds. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

The Development of Wake Turbulence Recategorization in the United States

DOT National Transportation Integrated Search

2016-06-13

This paper describes the background information and provides a status update on a : specific aspect of the Federal Aviation Administration (FAA) wake turbulence program : known as RECAT (i.e., Recategorization). The fundamental premise of RECAT is th...

Arsenic surveillance program

NASA Technical Reports Server (NTRS)

1993-01-01

Background information about arsenic is presented including forms, common sources, and clinical symptoms of arsenic exposure. The purpose of the Arsenic Surveillance Program and LeRC is outlined, and the specifics of the Medical Surveillance Program for Arsenic Exposure at LeRC are discussed.

Solid Waste Information and Tracking System Client Server Conversion Project Management Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

GLASSCOCK, J.A.

2000-02-10

The Project Management Plan governing the conversion of SWITS to a client-server architecture. The PMP describes the background, planning and management of the SWITS conversion. Requirements and specification documentation needed for the SWITS conversion

Field trip guide to the 2010 Schultz Fire Burn Area

Treesearch

Karen Koestner; Anne Youberg; Daniel G. Neary

2011-01-01

This field trip guide was created for a September 18th, 2011, field trip to the 2010 Schultz Fire burn area northeast of Flagstaff, Arizona, as part of the Arizona Hydrological Society's Annual Symposium. The guide provides background information on the 2010 Schultz Fire and aftermath (Section 1), site-specific information for each stop on the field trip (Section...

Consortium for the Application of Space Data to Education - CASDE

NASA Technical Reports Server (NTRS)

Zygielbaum, A.; Rundquist, D.; Stork, E. J.

1995-01-01

From Background section: The Conortium for the Application of Space Data to Education (CASDE) was formed to make space data holdings more easily accessible to educators and students. CASDE will take an even greater step and work with educators to develop specific sets of data and information, and concomitant software to apply these holdings to specific curricula in a diverse set of subjects.

Environmental Awareness and Environmental Education in Myanmar.

ERIC Educational Resources Information Center

Win, Hla Hla

2001-01-01

Provides background information on environmental issues and conservation within Myanmar (formerly Burma). Discusses environmental education, focusing specifically on primary education in Myanmar. Explores the effectiveness of environmental education by using four questions to guide the evaluation, such as why environmental education is taught and…

Association between a social-business eating pattern and early asymptomatic atherosclerosis

USDA-ARS?s Scientific Manuscript database

BACKGROUND: The importance of a healthy diet in relation to cardiovascular health promotion is widely recognized. Identifying specific dietary patterns related to early atherosclerosis would contribute greatly to inform effective primary prevention strategies. OBJECTIVES: This study sought to quanti...

Ladybirds as Teaching Aids: 2. Potential for Practical and Project Work.

ERIC Educational Resources Information Center

Majerus, M. E. N.; And Others

1989-01-01

Presented are several ideas for projects involving ladybird beetles. Discussed is background information about the insects; and projects involving life histories, intra-specific variation, taxonomy, genetics, behavior, ecology, habitat surveys, population biology, and overwintering biology. Lists 12 references. (CW)

Review & Peer Review of “Parameters for Properly Designed and Operated Flares” Documents

EPA Pesticide Factsheets

This page contains two 2012 memoranda on the review of EPA's parameters for properly designed and operated flares. One details the process of peer review, and the other provides background information and specific charge questions to the panel.

Psychological Approaches to Problems of Children and Adolescents.

ERIC Educational Resources Information Center

Grimes, Jeff, Ed.

This document, intended as a resource for school psychologists, contains articles addressing a variety of psychological and behavioral problems of children and adolescents. Each chapter includes the following content: background information concerning the specific topic, approaches for assessing the behavior of concern, intervention possibilities,…

A method to characterise site, urban and regional ambient background radiation.

PubMed

Passmore, C; Kirr, M

2011-03-01

Control dosemeters are routinely provided to customers to monitor the background radiation so that it can be subtracted from the gross response of the dosemeter to arrive at the occupational dose. Landauer, the largest dosimetry processor in the world with subsidiaries in Australia, Brazil, China, France, Japan, Mexico and the UK, has clients in approximately 130 countries. The Glenwood facility processes over 1.1 million controls per year. This network of clients around the world provides a unique ability to monitor the world's ambient background radiation. Control data can be mined to provide useful historical information regarding ambient background rates and provide a historical baseline for geographical areas. Historical baseline can be used to provide site or region-specific background subtraction values, document the variation in ambient background radiation around a client's site or provide a baseline for measuring the efficiency of clean-up efforts in urban areas after a dirty bomb detonation.

Combining rules, background knowledge and change patterns to maintain semantic annotations.

PubMed

Cardoso, Silvio Domingos; Chantal, Reynaud-Delaître; Da Silveira, Marcos; Pruski, Cédric

2017-01-01

Knowledge Organization Systems (KOS) play a key role in enriching biomedical information in order to make it machine-understandable and shareable. This is done by annotating medical documents, or more specifically, associating concept labels from KOS with pieces of digital information, e.g., images or texts. However, the dynamic nature of KOS may impact the annotations, thus creating a mismatch between the evolved concept and the associated information. To solve this problem, methods to maintain the quality of the annotations are required. In this paper, we define a framework based on rules, background knowledge and change patterns to drive the annotation adaption process. We evaluate experimentally the proposed approach in realistic cases-studies and demonstrate the overall performance of our approach in different KOS considering the precision, recall, F1-score and AUC value of the system.

Combining rules, background knowledge and change patterns to maintain semantic annotations

PubMed Central

Cardoso, Silvio Domingos; Chantal, Reynaud-Delaître; Da Silveira, Marcos; Pruski, Cédric

2017-01-01

Knowledge Organization Systems (KOS) play a key role in enriching biomedical information in order to make it machine-understandable and shareable. This is done by annotating medical documents, or more specifically, associating concept labels from KOS with pieces of digital information, e.g., images or texts. However, the dynamic nature of KOS may impact the annotations, thus creating a mismatch between the evolved concept and the associated information. To solve this problem, methods to maintain the quality of the annotations are required. In this paper, we define a framework based on rules, background knowledge and change patterns to drive the annotation adaption process. We evaluate experimentally the proposed approach in realistic cases-studies and demonstrate the overall performance of our approach in different KOS considering the precision, recall, F1-score and AUC value of the system. PMID:29854115

Plug in to the Utah Library Network, Reach Out to the World. Utah Library Network and Internet Training Handbook [for DOS]. Information Forum Publication #7.

ERIC Educational Resources Information Center

Reinwand, Louis; And Others

This manual is designed to assist public libraries in Utah in their use of the Internet. Many of the examples used were created specifically to explain the use of products that the Utah Library Network provides for public libraries in Utah. The introduction provides background history and general information about the Internet and general…

Systematics errors in strong lens modeling

NASA Astrophysics Data System (ADS)

Johnson, Traci L.; Sharon, Keren; Bayliss, Matthew B.

We investigate how varying the number of multiple image constraints and the available redshift information can influence the systematic errors of strong lens models, specifically, the image predictability, mass distribution, and magnifications of background sources. This work will not only inform upon Frontier Field science, but also for work on the growing collection of strong lensing galaxy clusters, most of which are less massive and are capable of lensing a handful of galaxies.

75 FR 36211 - Requirements for Distribution of Byproduct Material

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-24

.... Submitting Comments and Accessing Information II. Background A. Introduction B. Regulatory Framework III.... Introduction The Commission has authority to issue both general and specific licenses for the use of byproduct... Products As noted in the introduction on regulatory framework, class exemptions allow the Commission to...

The Industrial Revolution: An ERIC/ChESS Sample.

ERIC Educational Resources Information Center

Pinhey, Laura A.

2000-01-01

Provides a list, from the ERIC database, of teaching materials and background information on the Industrial Revolution. Specific topics include life in Lowell (Massachusetts), the global impact of the Industrial Revolution, and England's Industrial Revolution. Offers directions for obtaining the full text of these materials. (CMK)

Salads, Sandwiches and Desserts.

ERIC Educational Resources Information Center

Marine Corps Inst., Washington, DC.

Developed as part of the Marine Corps Institute (MCI) correspondence training program, this course on salads, sandwiches, and desserts is designed to provide Marine food service personnel with a general background in the proper techniques for the preparation of these items. Introductory materials include specific information for MCI students and a…

Helping Chinese Children Become More Creative

ERIC Educational Resources Information Center

Huang, Pingting; Szente, Judit

2014-01-01

This article provides information about children's creativity in the People's Republic of China. More specifically, it introduces the Chinese cultural and social background along with the school and family environments as they relate to young children's creativity. The article also provides some suggestions for schools and families to foster…

A Background of a Volatile Plant Compound Alters Neural and Behavioral Responses to the Sex Pheromone Blend in a Moth.

PubMed

Dupuy, Fabienne; Rouyar, Angéla; Deisig, Nina; Bourgeois, Thomas; Limousin, Denis; Wycke, Marie-Anne; Anton, Sylvia; Renou, Michel

2017-01-01

Recognition of intra-specific olfactory signals within a complex environment of plant-related volatiles is crucial for reproduction in male moths. Sex pheromone information is detected by specific olfactory receptor neurons (Phe-ORNs), highly abundant on the male antenna. The information is then transmitted to the pheromone processing macroglomerular complex (MGC) within the primary olfactory center, the antennal lobe, where it is processed by local interneurons and projection neurons. Ultimately a behavioral response, orientation toward the pheromone source, is elicited. Volatile plant compounds (VPCs) are detected by other functional types of olfactory receptor neurons (ORNs) projecting in another area of the antennal lobe. However, Phe-ORNs also respond to some VPCs. Female-produced sex pheromones are emitted within a rich environment of VPCs, some of which have been shown to interfere with the detection and processing of sex pheromone information. As interference between the different odor sources might depend on the spatial and temporal features of the two types of stimuli, we investigated here behavioral and neuronal responses to a brief sex pheromone blend pulse in a VPC background as compared to a control background in the male noctuid moth Agrotis ipsilon . We observed male orientation behavior in a wind tunnel and recorded responses of Phe-ORNs and MGC neurons to a brief sex pheromone pulse within a background of individual VPCs. We also recorded the global input signal to the MGC using in vivo calcium imaging with the same stimulation protocol. We found that VPCs eliciting a response in Phe-ORNs and MGC neurons masked responses to the pheromone and decreased the contrast between background odor and the sex pheromone at both levels, whereas α-pinene did not interfere with first order processing. The calcium signal produced in response to a VPC background was tonic, lasting longer than the VPC stimulus duration, and masked entirely the pheromone response. One percent heptanal and linalool, in addition to the masking effect, caused a clear delay in responses of MGC neurons to the sex pheromone. Upwind flight toward the pheromone in a wind tunnel was also delayed but otherwise not altered by different doses of heptanal.

Estimating Time to the Common Ancestor for a Beneficial Allele

PubMed Central

Smith, Joel; Coop, Graham; Stephens, Matthew; Novembre, John

2018-01-01

Abstract The haplotypes of a beneficial allele carry information about its history that can shed light on its age and the putative cause for its increase in frequency. Specifically, the signature of an allele’s age is contained in the pattern of variation that mutation and recombination impose on its haplotypic background. We provide a method to exploit this pattern and infer the time to the common ancestor of a positively selected allele following a rapid increase in frequency. We do so using a hidden Markov model which leverages the length distribution of the shared ancestral haplotype, the accumulation of derived mutations on the ancestral background, and the surrounding background haplotype diversity. Using simulations, we demonstrate how the inclusion of information from both mutation and recombination events increases accuracy relative to approaches that only consider a single type of event. We also show the behavior of the estimator in cases where data do not conform to model assumptions, and provide some diagnostics for assessing and improving inference. Using the method, we analyze population-specific patterns in the 1000 Genomes Project data to estimate the timing of adaptation for several variants which show evidence of recent selection and functional relevance to diet, skin pigmentation, and morphology in humans. PMID:29361025

Evaluation of the effectiveness of Gaussian filtering in distinguishing punctate synaptic signals from background noise during image analysis.

PubMed

Iwabuchi, Sadahiro; Kakazu, Yasuhiro; Koh, Jin-Young; Harata, N Charles

2014-02-15

Images in biomedical imaging research are often affected by non-specific background noise. This poses a serious problem when the noise overlaps with specific signals to be quantified, e.g. for their number and intensity. A simple and effective means of removing background noise is to prepare a filtered image that closely reflects background noise and to subtract it from the original unfiltered image. This approach is in common use, but its effectiveness in identifying and quantifying synaptic puncta has not been characterized in detail. We report on our assessment of the effectiveness of isolating punctate signals from diffusely distributed background noise using one variant of this approach, "Difference of Gaussian(s) (DoG)" which is based on a Gaussian filter. We evaluated immunocytochemically stained, cultured mouse hippocampal neurons as an example, and provided the rationale for choosing specific parameter values for individual steps in detecting glutamatergic nerve terminals. The intensity and width of the detected puncta were proportional to those obtained by manual fitting of two-dimensional Gaussian functions to the local information in the original image. DoG was compared with the rolling-ball method, using biological data and numerical simulations. Both methods removed background noise, but differed slightly with respect to their efficiency in discriminating neighboring peaks, as well as their susceptibility to high-frequency noise and variability in object size. DoG will be useful in detecting punctate signals, once its characteristics are examined quantitatively by experimenters. Copyright © 2013 Elsevier B.V. All rights reserved.

Simulating Issue Networks in Small Classes using the World Wide Web.

ERIC Educational Resources Information Center

Josefson, Jim; Casey, Kelly

2000-01-01

Provides background information on simulations and active learning. Discusses the use of simulations in political science courses. Describes a simulation exercise where students performed specific institutional role playing, simulating the workings of a single congressional issue network, based on the reauthorization of the Endangered Species Act.…

Current information technology needs of small to medium sized apparel manufacturers and contractors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wipple, C.; Vosti, E.

1997-11-01

This report documents recent efforts of the American Textile Partnership (AMTEX) Demand Activated Manufacturing Architecture (DAMA) Project to address needs that are characterized of small to medium sized apparel manufactures and contractors. Background on the AMTEX/DAMA project and objectives for this specific efforts are discussed.

Using JournalMap to improve ecological knowledge discovery and visualization

USDA-ARS?s Scientific Manuscript database

Background/Question/Methods Most of the ecological research conducted around the world is tied to specific places, however, that location information is locked up in the text and figures of scientific articles in myriad forms that are not easily searchable. While access to ecological literature ha...

HEALTH AND NUTRITION LESSON PLANS AND STUDENT WORKSHEETS, ADULT BASIC EDUCATION.

ERIC Educational Resources Information Center

New York State Education Dept., Albany.

THIS MANUAL PROVIDES ADULT BASIC EDUCATION TEACHERS WITH LESSON PLANS IN HEALTH AND NUTRITION. EACH LESSON CONTAINS BACKGROUND MATERIAL OFFERING SPECIFIC INFORMATION ON THE SUBJECT OF EACH LESSON, AIMS, LESSON DEVELOPMENT, AND TWO STUDENT WORKSHEETS. DISCUSSION QUESTIONS ARE SUGGESTED TO ENCOURAGE THE GREATEST POSSIBLE STUDENT INVOLVEMENT. THE TEN…

77 FR 18251 - Development of Animal Models of Pregnancy To Address Medical Countermeasures for Influenza in the...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-27

... during pregnancy. Specifically, this workshop will address experimental design issues in selecting the... countermeasures, including influenza therapies, that may be used during pregnancy; and (3) experimental design... pharmacokinetic studies, and (3) additional issues in experimental design. Background information on the public...

African-German Cooperation in Educational Research and Planning.

ERIC Educational Resources Information Center

Sachsenmeier, Peter

The report presents background information and proceedings from a conference held in Bonn, Germany, in September 1977 to encourage exchange of ideas between African and German educators and government officials. Specifically, the conference served to document the increasing interest of German educators to interact with educators from the third…

Development and Evaluation of a Computerized Engagement Intervention for IPS Supported Employment

ERIC Educational Resources Information Center

Haslett, William R.

2013-01-01

Background: Current information technology offers the promise of innovative approaches to engagement for mental health. Specific psychosocial services may also benefit from technology-based engagement interventions. Individual Placement and Support (IPS) is an evidence-based service that helps people who have a severe mental illness to gain…

[Rural Education Studies.

ERIC Educational Resources Information Center

Wright, Betty Atwell

The Rural Education Studies albums (oversized photographs printed on heavy coated cardboard) are published in a set of 8, each of which has a separate teacher's guide to complement the contents. A comprehensive teacher's guide provides background studies for effective use of the series, as well as providing specific information and key-concepts…

HR Shared Services and the Realignment of HR.

ERIC Educational Resources Information Center

Reilly, P.

This report examines how adopting the shared services model of human resources (HR) services delivery can help businesses achieve better alignment between their HR service and specific business needs. Chapter 1 provides background information on the research project underlying this report, which included the following data collection activities:…

Word Reading Aloud Skills: Their Positive Redefinition through Ageing

ERIC Educational Resources Information Center

Chapleau, Marianne; Wilson, Maximiliano A.; Potvin, Karel; Harvey-Langton, Alexandra; Montembeault, Maxime; Brambati, Simona M.

2017-01-01

Background: Successful reading can be achieved by means of two different procedures: sub-word processes for the pronunciation of words without semantics or pseudowords (PW) and whole-word processes that recruit word-specific information regarding the pronunciation of words with atypical orthography-to-phonology mappings (exception words, EW).…

Teaching and Learning in a Microelectronic Age.

ERIC Educational Resources Information Center

Shane, Harold G.

General background information on microtechnologies with implications for educators provides an introduction to this review of past and current developments in microelectronics and specific ways in which the microchip is permeating society, creating problems and opportunities both in the workplace and the home. Topics discussed in the first of two…

Negative and Atypical Story Content Themes Depicted by Children with Behaviour Problems

ERIC Educational Resources Information Center

Wan, Ming Wai; Green, Jonathan

2010-01-01

Background: Specific thematic content arising from children's doll play is often considered to give clinically meaningful information regarding their mental state, but has received little systematic enquiry. This exploratory study examined the negative and atypical content themes in the attachment story narratives of children with behaviour…

Recruitment to Intellectual Disability Research: A Qualitative Study

ERIC Educational Resources Information Center

Nicholson, L.; Colyer, M.; Cooper, S. -A.

2013-01-01

Background: Difficulties in the recruitment of adults with intellectual disability (ID) to research studies are well described but little studied. The aim of this study was to investigate the difficulties in recruiting to a specific research project, in order to inform future recruitment to ID research. Methods: Individual semi-structured…

Specifications of the International Cooperation Administration for DDT water-dispersible powder for use in malaria control programmes

PubMed Central

Pearce, George W.; Gooden, E. L.; Johnson, Donald R.

1959-01-01

Background information is presented on the development of specifications for 75% DDT water-dispersible powder for use in malaria control programmes supported by the International Cooperation Administration (ICA) of the United States Government. Early difficulties with DDT powders used in these programmes were investigated and it was found that the most critical requirements involved packaging, suspensibility and storage stability. ICA specifications were evolved to meet these requirements. The suspensibility test developed is described, and the importance of inspection of the material procured is discussed. PMID:14431217

Therapeutic Enactment: Integrating Individual and Group Counseling Models for Change

ERIC Educational Resources Information Center

Westwood, Marvin J.; Keats, Patrice A.; Wilensky, Patricia

2003-01-01

The purpose of this article is to introduce the reader to a group-based therapy model known as therapeutic enactment. A description of this multimodal change model is provided by outlining the relevant background information, key concepts related to specific change processes, and the differences in this model compared to earlier psychodrama…

Learning from History: World War II and the Culture of High Technology.

ERIC Educational Resources Information Center

Miller, Carolyn R.

1998-01-01

Outlines some resources for understanding technology as an important aspect of the late-twentieth-century American culture. Provides helpful background that can inform and shape further studies in the rhetoric of technology. Notes implications of this history for rhetorical study, specifically for how the rhetoric of technology may be distinct…

Lead-Free vs Tin-Lead Reliability of Advanced Electronic Assemblies

NASA Technical Reports Server (NTRS)

Ghaffarian, Reza

2005-01-01

This presentation will provide the technical background and specific information published in literature related to reliability test, analyses, modeling, and associated issues for lead-free solder package assemblies in comparison to their tin-lead solder alloys. It also presents current understanding of lead-free thermal cycle test performance in support.

Review of Visual Speech Perception by Hearing and Hearing-Impaired People: Clinical Implications

ERIC Educational Resources Information Center

Woodhouse, Lynn; Hickson, Louise; Dodd, Barbara

2009-01-01

Background: Speech perception is often considered specific to the auditory modality, despite convincing evidence that speech processing is bimodal. The theoretical and clinical roles of speech-reading for speech perception, however, have received little attention in speech-language therapy. Aims: The role of speech-read information for speech…

76 FR 55609 - Energy Conservation Program for Consumer Products: Request for Exclusion of 120 Volt, 100 Watt...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-08

... of R20 Short Lamps and Unavailability of Substitutes D. Request for Information I. Background The... or has special characteristics not available in substitute lamp types. Specifically, as the lamp has... manufacturers (including designated beam spread and lumen output), there are no substitute products on the...

Protein discovery: combined transcriptomic and proteomic analyses of venom from the endoparasitoid Cotesia chilonis (Hymenoptera: Brachonidae)

USDA-ARS?s Scientific Manuscript database

Background: Many species of endoparasitoid wasps provide biological control services in agroecosystems. Although there is a great deal of information on the ecology and physiology of host/parasitoid interactions, relatively little is known on the protein composition of venom and how specific venom p...

Adult Learning and Learners. PREL Briefing Paper.

ERIC Educational Resources Information Center

Timarong, Alvina; Temaungil, Marianne; Sukrad, Wilma

A survey of literature on adult learning and learners conducted for Palau Community College (PCC), Koror, Palau, found a lack of literature specific to the United States-affiliated Pacific region. Background information was compiled on development of formal education in Palau. A survey was administered in fall 2001 to adult learners working toward…

Native Americans: An Elementary Art Unit.

ERIC Educational Resources Information Center

Brown, Pat

This elementary art unit, which exposes students to the art and culture of American Indian tribes, is divided into four sections. Each section deals with a geographical area and a tribe or tribes within that area. Background information precedes instructions for art projects related to specific tribes. The influence of the environment on culture…

Initial Steps in Creating a Developmentally Valid Tool for Observing/Assessing Rope Jumping

ERIC Educational Resources Information Center

Roberton, Mary Ann; Thompson, Gregory; Langendorfer, Stephen J.

2017-01-01

Background: Valid motor development sequences show the various behaviors that children display as they progress toward competence in specific motor skills. Teachers can use these sequences to observe informally or formally assess their students. While longitudinal study is ultimately required to validate developmental sequences, there are earlier,…

Educating for a Just Society, Grades 7-12.

ERIC Educational Resources Information Center

McGinnis, Kathleen

This manual examines peace and justice themes with a specific domestic focus on issues rooted in the cultural, political, social, and economic fiber of the U.S. culture and economy. Each unit begins with overall goals for the unit with lessons developed around each goal. The lessons include brief background information for the teacher and…

Building a Conceptual Framework for Data Literacy

ERIC Educational Resources Information Center

Gummer, Edith; Mandinach, Ellen

2015-01-01

Background: The increasing focus on education as an evidence-based practice requires that educators can effectively use data to inform their practice. At the level of classroom instructional decision making, the nature of the specific knowledge and skills teachers need to use data effectively is complex and not well characterized. Being able to…

76 FR 6087 - Draft Weapons Safety Assessment on the Use of Enhanced Weapons; Notice of Availability and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-03

... holders, and other stakeholders on a draft guidance document entitled ``Weapons Safety Assessment'' (WSA... weapons under the NRC's proposed rule titled ``Enhanced Weapons, Firearms Background Checks, and Security.... You should not include any site-specific security information in your comments. Federal rulemaking Web...

Do Particular Design Features Assist People with Aphasia to Comprehend Text? An Exploratory Study

ERIC Educational Resources Information Center

Wilson, Lucy; Read, Jennifer

2016-01-01

Background: Much of the evidence underlying guidelines for producing accessible information for people with aphasia focuses on client preference for particular design features. There is limited evidence regarding the effects of these features on comprehension. Aims: To examine the effects of specific design features on text comprehension. It was…

Safety in Trade and Industrial and Technical Education.

ERIC Educational Resources Information Center

Thomas, John C.

Intended to serve as a resource guide to assist trade, industrial, and technical teachers in maintaining an effective and efficient safety program, the document does not contain information concerning the many specific operations of the various trades. The materials serve as a background for teachers as they develop their own units of instruction…

Inference and Sentence Comprehension in Children with Specific or Pragmatic Language Impairments

ERIC Educational Resources Information Center

Adams, Catherine; Clarke, Elaine; Haynes, Rebecca

2009-01-01

Background: Children with language impairments have difficulty in reporting verbal inferences, but it is unclear whether the source of this problem lies in limitations of language comprehension, an inability to access world knowledge, or the integration of information in discourse. Children with pragmatic language impairments (CwPLI) are often…

75 FR 40844 - Town Hall Discussion With the Director of the Center for Devices and Radiological Health and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-14

... Radiological Health (CDRH) Fiscal Year (FY) 2010 Priorities. In addition, FDA is interested in engaging in... and discuss issues of importance to the medical device industry. CDRH is specifically interested in... through Friday. SUPPLEMENTARY INFORMATION: I. Background CDRH has announced four priority areas of...

Detection of artifacts from high energy bursts in neonatal EEG.

PubMed

Bhattacharyya, Sourya; Biswas, Arunava; Mukherjee, Jayanta; Majumdar, Arun Kumar; Majumdar, Bandana; Mukherjee, Suchandra; Singh, Arun Kumar

2013-11-01

Detection of non-cerebral activities or artifacts, intermixed within the background EEG, is essential to discard them from subsequent pattern analysis. The problem is much harder in neonatal EEG, where the background EEG contains spikes, waves, and rapid fluctuations in amplitude and frequency. Existing artifact detection methods are mostly limited to detect only a subset of artifacts such as ocular, muscle or power line artifacts. Few methods integrate different modules, each for detection of one specific category of artifact. Furthermore, most of the reference approaches are implemented and tested on adult EEG recordings. Direct application of those methods on neonatal EEG causes performance deterioration, due to greater pattern variation and inherent complexity. A method for detection of a wide range of artifact categories in neonatal EEG is thus required. At the same time, the method should be specific enough to preserve the background EEG information. The current study describes a feature based classification approach to detect both repetitive (generated from ECG, EMG, pulse, respiration, etc.) and transient (generated from eye blinking, eye movement, patient movement, etc.) artifacts. It focuses on artifact detection within high energy burst patterns, instead of detecting artifacts within the complete background EEG with wide pattern variation. The objective is to find true burst patterns, which can later be used to identify the Burst-Suppression (BS) pattern, which is commonly observed during newborn seizure. Such selective artifact detection is proven to be more sensitive to artifacts and specific to bursts, compared to the existing artifact detection approaches applied on the complete background EEG. Several time domain, frequency domain, statistical features, and features generated by wavelet decomposition are analyzed to model the proposed bi-classification between burst and artifact segments. A feature selection method is also applied to select the feature subset producing highest classification accuracy. The suggested feature based classification method is executed using our recorded neonatal EEG dataset, consisting of burst and artifact segments. We obtain 78% sensitivity and 72% specificity as the accuracy measures. The accuracy obtained using the proposed method is found to be about 20% higher than that of the reference approaches. Joint use of the proposed method with our previous work on burst detection outperforms reference methods on simultaneous burst and artifact detection. As the proposed method supports detection of a wide range of artifact patterns, it can be improved to incorporate the detection of artifacts within other seizure patterns and background EEG information as well. © 2013 Elsevier Ltd. All rights reserved.

Remote sensing as a source of data for outdoor recreation planning

NASA Technical Reports Server (NTRS)

Reed, W. E.; Goodell, H. G.; Emmitt, G. D.

1972-01-01

Specific data needs for outdoor recreation planning and the ability of tested remote sensors to provide sources for these data are examined. Data needs, remote sensor capabilities, availability of imagery, and advantages and problems of incorporating remote sensing data sources into ongoing planning data collection programs are discussed in detail. Examples of the use of imagery to derive data for a range of common planning analyses are provided. A selected bibliography indicates specific uses of data in planning, basic background materials on remote sensing technology, and sources of information on environmental information systems expected to use remote sensing to provide new environmental data of use in outdoor recreation planning.

Data on multicultural education and diagnostic information profiling: Culture, learning styles and creativity.

PubMed

Maseleno, Andino; Hardaker, Glenn; Sabani, Noraisikin; Suhaili, Nabilah

2016-12-01

This article contains data related to multicultural education and diagnostic information profiling preliminary findings. It includes the responses of 253 students. The data consists of six sections, i) culture: race, ethnicity, language and identity; ii) learning preferences: physiological and perceptual; iii) cognitive learning styles: physical, emotional and mental; iv) creativity skills and problem solving skills; v) motivation; and vi) students' background knowledge. The data may be used as part of data analytics for specific personalized e-learning platform.

Conflicting Online Health Information and Rational Decision Making: Implication for Cancer Survivors.

PubMed

Yoon, Heesoo; Sohn, Minsung; Choi, Mankyu; Jung, Minsoo

Although people in the social media age can access health information easier, they have difficulty judging conflicting rational information or summarizing the large amounts of health information available. Conflicting health information occurs when contrary assertions or information about a certain health issue comes from different information sources. This study examined the background knowledge and the current phenomenon of why conflicting health information occurs in real-world conditions. We also reviewed causes and solutions by reviewing the literature. In particular, we recommend a method that solves problems that patients have including cancer survivors who cannot themselves be active in seeking health information. Thus, we categorized the specific types of conflicting health information and analyzed the sociodemographic factors and information carrier factors that have an impact on the health information-seeking behavior of individuals.

Predictive modelling: parents’ decision making to use online child health information to increase their understanding and/or diagnose or treat their child’s health

PubMed Central

2012-01-01

Background The quantum increases in home Internet access and available online health information with limited control over information quality highlight the necessity of exploring decision making processes in accessing and using online information, specifically in relation to children who do not make their health decisions. The aim of this study was to understand the processes explaining parents’ decisions to use online health information for child health care. Methods Parents (N = 391) completed an initial questionnaire assessing the theory of planned behaviour constructs of attitude, subjective norm, and perceived behavioural control, as well as perceived risk, group norm, and additional demographic factors. Two months later, 187 parents completed a follow-up questionnaire assessing their decisions to use online information for their child’s health care, specifically to 1) diagnose and/or treat their child’s suspected medical condition/illness and 2) increase understanding about a diagnosis or treatment recommended by a health professional. Results Hierarchical multiple regression showed that, for both behaviours, attitude, subjective norm, perceived behavioural control, (less) perceived risk, group norm, and (non) medical background were the significant predictors of intention. For parents’ use of online child health information, for both behaviours, intention was the sole significant predictor of behaviour. The findings explain 77% of the variance in parents’ intention to treat/diagnose a child health problem and 74% of the variance in their intentions to increase their understanding about child health concerns. Conclusions Understanding parents’ socio-cognitive processes that guide their use of online information for child health care is important given the increase in Internet usage and the sometimes-questionable quality of health information provided online. Findings highlight parents’ thirst for information; there is an urgent need for health professionals to provide parents with evidence-based child health websites in addition to general population education on how to evaluate the quality of online health information. PMID:23228171

Deficits in Facial Expression Recognition in Male Adolescents with Early-Onset or Adolescence-Onset Conduct Disorder

ERIC Educational Resources Information Center

Fairchild, Graeme; Van Goozen, Stephanie H. M.; Calder, Andrew J.; Stollery, Sarah J.; Goodyer, Ian M.

2009-01-01

Background: We examined whether conduct disorder (CD) is associated with deficits in facial expression recognition and, if so, whether these deficits are specific to the early-onset form of CD, which emerges in childhood. The findings could potentially inform the developmental taxonomic theory of antisocial behaviour, which suggests that…

Science, Technology and Society in Contemporary Egypt: Background Information for Social Studies Teachers.

ERIC Educational Resources Information Center

1989

Egypt is having a very difficult time supplying enough food to meet the demands of its swelling population. This complex problem is analyzed and discussed from a variety of perspectives. Factors such as foreign aid, family planning, agriculture, demographics, and religious and social culture are examined, as well as more specific issues such as…

CTE's Role in Energy and Environmental Sustainability

ERIC Educational Resources Information Center

Hyslop, Alisha

2009-01-01

ACTE Issue Briefs are designed to highlight the role of career and technical education (CTE) in a broader issue of national interest. Each Brief is designed to strengthen the voice of CTE related to the specific issue and to draw more attention to CTE activities and best practices around the country. The Briefs provide background information,…

Confirming the Etiology of Adolescent Acting-out Behaviors: An Examination of Observer-Ratings in a Sample of Adoptive and Biological Siblings

ERIC Educational Resources Information Center

Burt, S. Alexandra; Klahr, Ashlea M.; Rueter, Martha A.; McGue, Matt; Iacono, William G.

2011-01-01

Background: A recent meta-analysis revealed moderate shared environmental influences (C) on most forms of child and adolescent psychopathology (Burt, 2009), including antisocial behavior. Critically, however, the research analyzed in this meta-analysis relied largely on specific informant-reports (and particularly parent and child reports), each…

Capabilities of radar as they might relate to entomological studies

NASA Technical Reports Server (NTRS)

Skolnik, M. I.

1979-01-01

A tutoral background of radar capabilities and its potential for insect research is provided. The basic principles and concepts of radar were reviewed. Information on current radar equipment was examined. Specific issues related to insect research included; target cross-section, radar frequency, tracking target recognition and false alarms, clutter reduction, radar transmitter power, and ascertained atmospheric processes.

A Study Identifying the Components of a Quality Child Care Center.

ERIC Educational Resources Information Center

Panetta, Sandra J.

Specific characteristics of a quality day care center are identified through a survey of parents, teachers, and directors utilizing or working in day care centers. The introduction to this descriptive research study offers background information on the history of the child care movement in America and a review of related research projects. A…

Handbook for a Commitment to America's Future: A Toolkit for Leaders of State-Level P-16

ERIC Educational Resources Information Center

Business-Higher Education Forum (NJ1), 2005

2005-01-01

This handbook provides P-16 council leaders with a toolkit of background information and proposed procedures for structuring and guiding implementation of Business-Higher Education Forum's (BHEF) proposed action plan. Specifically, it details a four-part nationwide action plan to improve overall pre-kindergarten through high school (P-12)…

76 FR 53475 - Medicare Program; Meeting of the Medicare Evidence Development and Coverage Advisory Committee...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-26

.... Your comments should focus on issues specific to the list of topics that we have proposed to the Committee. The list of research topics to be discussed at the meeting will be available on the following Web... disease. Background information about this topic, including panel materials, is available at http://www...

78 FR 13059 - Medicare Program; Meeting of the Medicare Evidence Development and Coverage Advisory Committee...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-26

... request to speak by April 1, 2013. Your comments should focus on issues specific to the list of topics that we have proposed to the Committee. The list of research topics to be discussed at the meeting will... clinical significance). Background information about this topic, including panel materials, is available at...

75 FR 73094 - Medicare Program; Meeting of the Medicare Evidence Development and Coverage Advisory Committee...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-29

... available. Your comments should focus on issues specific to the list of topics that we have proposed to the Committee. The list of research topics to be discussed at the meeting will be available on the following Web... (CKD) patients (pre- dialysis and dialysis). Background information about this topic, including panel...

77 FR 53204 - Medicare Program; Meeting of the Medicare Evidence Development and Coverage Advisory Committee...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-31

.... Your comments should focus on issues specific to the list of topics that we have proposed to the Committee. The list of research topics to be discussed at the meeting will be available on the following web... management of heart failure. Background information about this topic, including panel materials, is available...

76 FR 71569 - Medicare Program; Meeting of the Medicare Evidence Development and Coverage Advisory Committee...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-18

... December 22, 2011. Your comments should focus on issues specific to the list of topics that we have proposed to the Committee. The list of research topics to be discussed at the meeting will be available on... atherosclerosis. Background information about this topic, including panel materials, is available at http://www...

77 FR 64997 - Medicare Program; Meeting of the Medicare Evidence Development and Coverage Advisory Committee...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-24

... focus on issues specific to the list of topics that we have proposed to the Committee. The list of research topics to be discussed at the meeting will be available on the following Web site prior to the... neurodegenerative disease. Background information about this topic, including panel materials, is available at http...

75 FR 8980 - Medicare Program; Meeting of the Medicare Evidence Development and Coverage Advisory Committee...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-26

... available. Your comments should focus on issues specific to the list of topics that we have proposed to the Committee. The list of research topics to be discussed at the meeting will be available on the following Web... prostate cancer. Background information about this topic, including panel materials, is available at http...

Selected Bibliography on Culture and Cultural Materials, Preliminary Edition. Series A: Reference Materials, Human Relations in Cultural Context.

ERIC Educational Resources Information Center

Condon, E. C.; And Others

Included in this bibliography are references to resources and materials available to the teacher and educator on human relations and cultural education. The bibliography is divided into three sections on culture, specific culture, and adult bilingual-bicultural education. The section on culture presents background information on the relation of…

Progress Towards a Neutral Current $$\\pi^0$$ Cross Section Analysis in the NOvA Near Detector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bowles, Reed; Paley, Jonathan

The NOvA neutrino experiment is attempting to measure properties of neutrinos in order to figure out information about the universe. To detect the signal neutrino interactions, we must determine methods to identify and isolate background events. Research focused on a specific background interaction called a single prong neutral currentmore » $$\\pi^0$$ interaction. To do this, a basic cuts based analysis was performed, followed by feeding data into a multi-variate analysis package using a boosted decision tree (BDT) algorithm. Using the BDT, a a new variable was generated which separates signal and background very efficiently. Further work must still be done in order to continue improving the performance of the BDT. This research is valuable to the field of studying neutrino cross sections as it is a background which will always be present in this type of analysis.« less

An interactive ontology-driven information system for simulating background radiation and generating scenarios for testing special nuclear materials detection algorithms

DOE PAGES

Sorokine, Alexandre; Schlicher, Bob G.; Ward, Richard C.; ...

2015-05-22

This paper describes an original approach to generating scenarios for the purpose of testing the algorithms used to detect special nuclear materials (SNM) that incorporates the use of ontologies. Separating the signal of SNM from the background requires sophisticated algorithms. To assist in developing such algorithms, there is a need for scenarios that capture a very wide range of variables affecting the detection process, depending on the type of detector being used. To provide such a cpability, we developed an ontology-driven information system (ODIS) for generating scenarios that can be used in creating scenarios for testing of algorithms for SNMmore » detection. The ontology-driven scenario generator (ODSG) is an ODIS based on information supplied by subject matter experts and other documentation. The details of the creation of the ontology, the development of the ontology-driven information system, and the design of the web user interface (UI) are presented along with specific examples of scenarios generated using the ODSG. We demonstrate that the paradigm behind the ODSG is capable of addressing the problem of semantic complexity at both the user and developer levels. Compared to traditional approaches, an ODIS provides benefits such as faithful representation of the users' domain conceptualization, simplified management of very large and semantically diverse datasets, and the ability to handle frequent changes to the application and the UI. Furthermore, the approach makes possible the generation of a much larger number of specific scenarios based on limited user-supplied information« less

International medical students – a survey of perceived challenges and established support services at medical faculties

PubMed Central

Huhn, D.; Junne, F.; Zipfel, S.; Duelli, R.; Resch, F.; Herzog, W.; Nikendei, C.

2015-01-01

Introduction: Medical students with a non-German background face several challenges during their studies. Besides support given by foreign student offices further specific projects for international students have been developed and are offered by medical faculties. However, so far, neither a systematic survey of the faculties’ perceived problems nor of the offered support exists. Method: All study deaneries of medical faculties in Germany were contacted between April and October 2013 and asked for their participation in a telephone interview. Interview partners were asked about 1.) The percentage of non-German students at the medical faculty; 2.) The perceived difficulties and problems of foreign students; 3.) The offers for non-German students; and 4.) The specification of further possibilities of support. Given information was noted, frequencies counted and results interpreted via frequency analysis. Results: Only 39% of the medical faculties could give detailed information about the percentage of non-German students. They reported an average share of 3.9% of students with an EU migration background and 4.9% with a non-EU background. Most frequently cited offers are student conducted tutorials, language courses and tandem-programs. The most frequently reported problem by far is the perceived lack of language skills of foreign students at the beginning of their studies. Suggested solutions are mainly the development of tutorials and the improvement of German medical terminology. Discussion: Offers of support provided by medical faculties for foreign students vary greatly in type and extent. Support offered is seen to be insufficient in coping with the needs of the international students in many cases. Hence, a better coverage of international students as well as further research efforts to the specific needs and the effectiveness of applied interventions seem to be essential. PMID:25699112

Deconstructing Visual Scenes in Cortex: Gradients of Object and Spatial Layout Information

PubMed Central

Kravitz, Dwight J.; Baker, Chris I.

2013-01-01

Real-world visual scenes are complex cluttered, and heterogeneous stimuli engaging scene- and object-selective cortical regions including parahippocampal place area (PPA), retrosplenial complex (RSC), and lateral occipital complex (LOC). To understand the unique contribution of each region to distributed scene representations, we generated predictions based on a neuroanatomical framework adapted from monkey and tested them using minimal scenes in which we independently manipulated both spatial layout (open, closed, and gradient) and object content (furniture, e.g., bed, dresser). Commensurate with its strong connectivity with posterior parietal cortex, RSC evidenced strong spatial layout information but no object information, and its response was not even modulated by object presence. In contrast, LOC, which lies within the ventral visual pathway, contained strong object information but no background information. Finally, PPA, which is connected with both the dorsal and the ventral visual pathway, showed information about both objects and spatial backgrounds and was sensitive to the presence or absence of either. These results suggest that 1) LOC, PPA, and RSC have distinct representations, emphasizing different aspects of scenes, 2) the specific representations in each region are predictable from their patterns of connectivity, and 3) PPA combines both spatial layout and object information as predicted by connectivity. PMID:22473894

An incremental knowledge assimilation system (IKAS) for mine detection

NASA Astrophysics Data System (ADS)

Porway, Jake; Raju, Chaitanya; Varadarajan, Karthik Mahesh; Nguyen, Hieu; Yadegar, Joseph

2010-04-01

In this paper we present an adaptive incremental learning system for underwater mine detection and classification that utilizes statistical models of seabed texture and an adaptive nearest-neighbor classifier to identify varied underwater targets in many different environments. The first stage of processing uses our Background Adaptive ANomaly detector (BAAN), which identifies statistically likely target regions using Gabor filter responses over the image. Using this information, BAAN classifies the background type and updates its detection using background-specific parameters. To perform classification, a Fully Adaptive Nearest Neighbor (FAAN) determines the best label for each detection. FAAN uses an extremely fast version of Nearest Neighbor to find the most likely label for the target. The classifier perpetually assimilates new and relevant information into its existing knowledge database in an incremental fashion, allowing improved classification accuracy and capturing concept drift in the target classes. Experiments show that the system achieves >90% classification accuracy on underwater mine detection tasks performed on synthesized datasets provided by the Office of Naval Research. We have also demonstrated that the system can incrementally improve its detection accuracy by constantly learning from new samples.

Exploring Encoding and Retrieval Effects of Background Information on Text Memory

ERIC Educational Resources Information Center

Rawson, Katherine A.; Kintsch, Walter

2004-01-01

Two experiments were conducted (a) to evaluate how providing background information at test may benefit retrieval and (b) to further examine how providing background information prior to study influences encoding. Half of the participants read background information prior to study, and the other half did not. In each group, half were presented…

Ensemble-based methods for forecasting census in hospital units

PubMed Central

2013-01-01

Background The ability to accurately forecast census counts in hospital departments has considerable implications for hospital resource allocation. In recent years several different methods have been proposed forecasting census counts, however many of these approaches do not use available patient-specific information. Methods In this paper we present an ensemble-based methodology for forecasting the census under a framework that simultaneously incorporates both (i) arrival trends over time and (ii) patient-specific baseline and time-varying information. The proposed model for predicting census has three components, namely: current census count, number of daily arrivals and number of daily departures. To model the number of daily arrivals, we use a seasonality adjusted Poisson Autoregressive (PAR) model where the parameter estimates are obtained via conditional maximum likelihood. The number of daily departures is predicted by modeling the probability of departure from the census using logistic regression models that are adjusted for the amount of time spent in the census and incorporate both patient-specific baseline and time varying patient-specific covariate information. We illustrate our approach using neonatal intensive care unit (NICU) data collected at Women & Infants Hospital, Providence RI, which consists of 1001 consecutive NICU admissions between April 1st 2008 and March 31st 2009. Results Our results demonstrate statistically significant improved prediction accuracy for 3, 5, and 7 day census forecasts and increased precision of our forecasting model compared to a forecasting approach that ignores patient-specific information. Conclusions Forecasting models that utilize patient-specific baseline and time-varying information make the most of data typically available and have the capacity to substantially improve census forecasts. PMID:23721123

Toward a sustainable European Network for Health Technology Assessment. The EUnetHTA project.

PubMed

Kristensen, F B; Chamova, J; Hansen, N W

2006-03-01

EUnetHTA is a recently initiated EU network aiming at connecting national HTA agencies, research institutions, and health ministries to enable an effective exchange of information and to lend support to health policy decisions by the Member States. The article briefly discusses the policy background, the specific objectives, and the project structure of the network.

AERA Statement on Use of Value-Added Models (VAM) for the Evaluation of Educators and Educator Preparation Programs

ERIC Educational Resources Information Center

Educational Researcher, 2015

2015-01-01

The purpose of this statement is to inform those using or considering the use of value-added models (VAM) about their scientific and technical limitations in the evaluation of educators and programs that prepare teachers. The statement briefly reviews the background and current context of using VAM for evaluations, enumerates specific psychometric…

Prosperity, Sustainable Employment and Social Justice: Challenges for the German Labor Market in the Twenty-First Century

ERIC Educational Resources Information Center

Möller, Joachim

2014-01-01

This paper analyzes the effects of German labor market reforms on the competitiveness and performance of the German economy. The contribution starts with giving some background information on the rationale behind the reforms and stresses the specific structure of the German economy. We then describe the salient effects of the reforms for…

Lesson Plan Manual, a Series of Lesson Plans and Worksheets on Consumer Education and Student Worksheets for Consumer Education Lesson Plans, Adult Basic Education.

ERIC Educational Resources Information Center

New York State Education Dept., Albany.

This manual provides teachers with lesson plans in consumer education. Each lesson contains background material offering the teacher specific information on the subject of the lesson, development of understandings, student worksheets, and discussion questions to encourage student involvement. The ten lesson plans are--Buying on time, Retail…

An Evaluation of the Implementation of National Core Curricula in Australia. Summary Report.

ERIC Educational Resources Information Center

Parkinson, Kevin J.; Broderick, John S.

As part of a study of the development and implementation of the National Core Curricula (NCC) in Australia, a historical background was prepared from a number of data sources and views on NCC were sought from senior Technical and Further Education (TAFE) officers in Australia. More specific information was sought in three case studies, the project…

Promoting Self-Esteem in Integrated Early Childhood Settings. AECA Resource Book Series, Volume 1, Number 3.

ERIC Educational Resources Information Center

Tarrant, Sue; Konza, Deslea

The development of a positive self-concept and self-esteem can affect thinking, feeling, attitudes, and behavior, and determine what children are and their successes in later life. Noting the importance of development of self-concept and self-esteem in the early years, this booklet provides some background information and specific strategies to…

Promoting Gender Equity in Middle and Secondary School Sports Programs. ERIC Digest.

ERIC Educational Resources Information Center

Priest, Laurie; Summerfield, Liane M.

This digest provides background information about gender equity in sports and physical activity as well as specific strategies for achieving equity at the middle and secondary school levels. The paper begins by describing gender equitable sports programs as ones in which either boys or girls would be pleased to accept as its own the program of the…

Manual for computing bed load transport using BAGS (Bedload Assessment for Gravel-bed Streams) Software

Treesearch

John Pitlick; Yantao Cui; Peter Wilcock

2009-01-01

This manual provides background information and instructions on the use of a spreadsheet-based program for Bedload Assessment in Gravel-bed Streams (BAGS). The program implements six bed load transport equations developed specifically for gravel-bed rivers. Transport capacities are calculated on the basis of field measurements of channel geometry, reach-average slope,...

Quantitative chemical imaging with background-free multiplex coherent anti-Stokes Raman scattering by dual-soliton Stokes pulses

PubMed Central

Chen, Kun; Wu, Tao; Wei, Haoyun; Zhou, Tian; Li, Yan

2016-01-01

Coherent anti-Stokes Raman microscopy (CARS) is a quantitative, chemically specific, and label-free optical imaging technique for studying inhomogeneous systems. However, the complicating influence of the nonresonant response on the CARS signal severely limits its sensitivity and specificity and especially limits the extent to which CARS microscopy has been used as a fully quantitative imaging technique. On the basis of spectral focusing mechanism, we establish a dual-soliton Stokes based CARS microspectroscopy and microscopy scheme capable of quantifying the spatial information of densities and chemical composition within inhomogeneous samples, using a single fiber laser. Dual-soliton Stokes scheme not only removes the nonresonant background but also allows robust acquisition of multiple characteristic vibrational frequencies. This all-fiber based laser source can cover the entire fingerprint (800-2200 cm−1) region with a spectral resolution of 15 cm−1. We demonstrate that quantitative degree determination of lipid-chain unsaturation in the fatty acids mixture can be achieved by the characterization of C = C stretching and CH2 deformation vibrations. For microscopy purposes, we show that the spatially inhomogeneous distribution of lipid droplets can be further quantitatively visualized using this quantified degree of lipid unsaturation in the acyl chain for contrast in the hyperspectral CARS images. The combination of compact excitation source and background-free capability to facilitate extraction of quantitative composition information with multiplex spectral peaks will enable wider applications of quantitative chemical imaging in studying biological and material systems. PMID:27867704

Reappraising Abstract Paintings after Exposure to Background Information

PubMed Central

Park, Seongmin A.; Yun, Kyongsik; Jeong, Jaeseung

2015-01-01

Can knowledge help viewers when they appreciate an artwork? Experts’ judgments of the aesthetic value of a painting often differ from the estimates of naïve viewers, and this phenomenon is especially pronounced in the aesthetic judgment of abstract paintings. We compared the changes in aesthetic judgments of naïve viewers while they were progressively exposed to five pieces of background information. The participants were asked to report their aesthetic judgments of a given painting after each piece of information was presented. We found that commentaries by the artist and a critic significantly increased the subjective aesthetic ratings. Does knowledge enable experts to attend to the visual features in a painting and to link it to the evaluative conventions, thus potentially causing different aesthetic judgments? To investigate whether a specific pattern of attention is essential for the knowledge-based appreciation, we tracked the eye movements of subjects while viewing a painting with a commentary by the artist and with a commentary by a critic. We observed that critics’ commentaries directed the viewers’ attention to the visual components that were highly relevant to the presented commentary. However, attention to specific features of a painting was not necessary for increasing the subjective aesthetic judgment when the artists’ commentary was presented. Our results suggest that at least two different cognitive mechanisms may be involved in knowledge- guided aesthetic judgments while viewers reappraise a painting. PMID:25945789

Effectiveness of Organ Donation Information Campaigns in Germany: A Facebook Based Online Survey

PubMed Central

Settmacher, Utz; Wurst, Christine; Dirsch, Olaf

2015-01-01

Background The German transplantation system is in a crisis due to a lack of donor organs. Information campaigns are one of the main approaches to increase organ donation rates. Since 2012, German health insurance funds are obliged by law to inform their members about organ donation. We raised the hypothesis: The willingness to sign a donor card rises due to the subsequent increase of specific knowledge by receiving the information material of the health insurance funds. Objective The objective of the study was to assess the influence of information campaigns on the specific knowledge and the willingness to donate organs. Methods We conducted an online survey based on recruitment via Facebook groups, advertisements using the snowball effect, and on mailing lists of medical faculties in Germany. Besides the demographic data, the willingness to hold an organ donor card was investigated. Specific knowledge regarding transplantation was explored using five factual questions resulting in a specific knowledge score. Results We recruited a total of 2484 participants, of which 32.7% (300/917) had received information material. Mean age was 29.9 (SD 11.0, median 26.0). There were 65.81% (1594/2422) of the participants that were female. The mean knowledge score was 3.28 of a possible 5.00 (SD 1.1, median 3.0). Holding a donor card was associated with specific knowledge (P<.001), but not with the general education level (P=.155). Receiving information material was related to holding a donor card (P<.001), but not to a relevant increase in specific knowledge (difference in mean knowledge score 3.20 to 3.48, P=.006). The specific knowledge score and the percentage of organ donor card holders showed a linear association (P<.001). Conclusions The information campaign was not associated with a relevant increase in specific knowledge, but with an increased rate in organ donor card holders. This effect is most likely related to the feeling of being informed, together with an easy access to the organ donor card. PMID:26220442

NASA's 2004 Hall Thruster Program

NASA Technical Reports Server (NTRS)

Jacobson, David T.; Manzella, David H.; Hofer, Richard R.; Peterson, Peter Y.

2004-01-01

An overview of NASA's Hall thruster research and development tasks conducted during fiscal year 2004 is presented. These tasks focus on: raising the technology readiness level of high power Hall thrusters, developing a moderate-power/ moderate specific impulse Hall thruster, demonstrating high-power/high specific impulse Hall thruster operation, and addressing the fundamental technical challenges of emerging Hall thruster concepts. Programmatic background information, technical accomplishments and out year plans for each program element performed under the sponsorship of the In-Space Transportation Program, Project Prometheus, and the Energetics Project are provided.

Solar thermal technical information guide

NASA Astrophysics Data System (ADS)

1985-05-01

This guide is designed to help investigators search for information in the solar thermal technology field. The information ranges from history and technology basics to the latest in research and develoment. It is written to help several audiences, including engineers and scientists who may be unfamiliar with a particular aspect of solar thermal energy, university researchers who are interested in the field, manufacturers needing to learn more about specific topics, and librarians who provide information to their clientele. The guide is divided into ten chapters, with Chapters 1 to 8 providing background on solar thermal energy development (including its history and current status) by topic. Within each topic, an overview is provided with references to relevant publications or information sources. Chapters 9 and 10 contain directories listing research centers and major technical information sources, respectively.

Retinotopic patterns of background connectivity between V1 and fronto-parietal cortex are modulated by task demands

PubMed Central

Griffis, Joseph C.; Elkhetali, Abdurahman S.; Burge, Wesley K.; Chen, Richard H.; Visscher, Kristina M.

2015-01-01

Attention facilitates the processing of task-relevant visual information and suppresses interference from task-irrelevant information. Modulations of neural activity in visual cortex depend on attention, and likely result from signals originating in fronto-parietal and cingulo-opercular regions of cortex. Here, we tested the hypothesis that attentional facilitation of visual processing is accomplished in part by changes in how brain networks involved in attentional control interact with sectors of V1 that represent different retinal eccentricities. We measured the strength of background connectivity between fronto-parietal and cingulo-opercular regions with different eccentricity sectors in V1 using functional MRI data that were collected while participants performed tasks involving attention to either a centrally presented visual stimulus or a simultaneously presented auditory stimulus. We found that when the visual stimulus was attended, background connectivity between V1 and the left frontal eye fields (FEF), left intraparietal sulcus (IPS), and right IPS varied strongly across different eccentricity sectors in V1 so that foveal sectors were more strongly connected than peripheral sectors. This retinotopic gradient was weaker when the visual stimulus was ignored, indicating that it was driven by attentional effects. Greater task-driven differences between foveal and peripheral sectors in background connectivity to these regions were associated with better performance on the visual task and faster response times on correct trials. These findings are consistent with the notion that attention drives the configuration of task-specific functional pathways that enable the prioritized processing of task-relevant visual information, and show that the prioritization of visual information by attentional processes may be encoded in the retinotopic gradient of connectivty between V1 and fronto-parietal regions. PMID:26106320

Pixelated camouflage patterns from the perspective of hyperspectral imaging

NASA Astrophysics Data System (ADS)

Racek, František; Jobánek, Adam; Baláž, Teodor; Krejčí, Jaroslav

2016-10-01

Pixelated camouflage patterns fulfill the role of both principles the matching and the disrupting that are exploited for blending the target into the background. It means that pixelated pattern should respect natural background in spectral and spatial characteristics embodied in micro and macro patterns. The HS imaging plays the similar, however the reverse role in the field of reconnaissance systems. The HS camera fundamentally records and extracts both the spectral and spatial information belonging to the recorded scenery. Therefore, the article deals with problems of hyperspectral (HS) imaging and subsequent processing of HS images of pixelated camouflage patterns which are among others characterized by their specific spatial frequency heterogeneity.

iASeq: integrative analysis of allele-specificity of protein-DNA interactions in multiple ChIP-seq datasets

PubMed Central

2012-01-01

Background ChIP-seq provides new opportunities to study allele-specific protein-DNA binding (ASB). However, detecting allelic imbalance from a single ChIP-seq dataset often has low statistical power since only sequence reads mapped to heterozygote SNPs are informative for discriminating two alleles. Results We develop a new method iASeq to address this issue by jointly analyzing multiple ChIP-seq datasets. iASeq uses a Bayesian hierarchical mixture model to learn correlation patterns of allele-specificity among multiple proteins. Using the discovered correlation patterns, the model allows one to borrow information across datasets to improve detection of allelic imbalance. Application of iASeq to 77 ChIP-seq samples from 40 ENCODE datasets and 1 genomic DNA sample in GM12878 cells reveals that allele-specificity of multiple proteins are highly correlated, and demonstrates the ability of iASeq to improve allelic inference compared to analyzing each individual dataset separately. Conclusions iASeq illustrates the value of integrating multiple datasets in the allele-specificity inference and offers a new tool to better analyze ASB. PMID:23194258

Integrating prior information into microwave tomography part 2: Impact of errors in prior information on microwave tomography image quality.

PubMed

Kurrant, Douglas; Fear, Elise; Baran, Anastasia; LoVetri, Joe

2017-12-01

The authors have developed a method to combine a patient-specific map of tissue structure and average dielectric properties with microwave tomography. The patient-specific map is acquired with radar-based techniques and serves as prior information for microwave tomography. The impact that the degree of structural detail included in this prior information has on image quality was reported in a previous investigation. The aim of the present study is to extend this previous work by identifying and quantifying the impact that errors in the prior information have on image quality, including the reconstruction of internal structures and lesions embedded in fibroglandular tissue. This study also extends the work of others reported in literature by emulating a clinical setting with a set of experiments that incorporate heterogeneity into both the breast interior and glandular region, as well as prior information related to both fat and glandular structures. Patient-specific structural information is acquired using radar-based methods that form a regional map of the breast. Errors are introduced to create a discrepancy in the geometry and electrical properties between the regional map and the model used to generate the data. This permits the impact that errors in the prior information have on image quality to be evaluated. Image quality is quantitatively assessed by measuring the ability of the algorithm to reconstruct both internal structures and lesions embedded in fibroglandular tissue. The study is conducted using both 2D and 3D numerical breast models constructed from MRI scans. The reconstruction results demonstrate robustness of the method relative to errors in the dielectric properties of the background regional map, and to misalignment errors. These errors do not significantly influence the reconstruction accuracy of the underlying structures, or the ability of the algorithm to reconstruct malignant tissue. Although misalignment errors do not significantly impact the quality of the reconstructed fat and glandular structures for the 3D scenarios, the dielectric properties are reconstructed less accurately within the glandular structure for these cases relative to the 2D cases. However, general agreement between the 2D and 3D results was found. A key contribution of this paper is the detailed analysis of the impact of prior information errors on the reconstruction accuracy and ability to detect tumors. The results support the utility of acquiring patient-specific information with radar-based techniques and incorporating this information into MWT. The method is robust to errors in the dielectric properties of the background regional map, and to misalignment errors. Completion of this analysis is an important step toward developing the method into a practical diagnostic tool. © 2017 American Association of Physicists in Medicine.

Battery electric vehicles - implications for the driver interface.

PubMed

Neumann, Isabel; Krems, Josef F

2016-03-01

The current study examines the human-machine interface of a battery electric vehicle (BEV) from a user-perspective, focussing on the evaluation of BEV-specific displays, the relevance of provided information and challenges for drivers due to the concept of electricity in a road vehicle. A sample of 40 users drove a BEV for 6 months. Data were gathered at three points of data collection. Participants perceived the BEV-specific displays as only moderately reliable and helpful for estimating the displayed parameters. This was even less the case after driving the BEV for 3 months. A taxonomy of user requirements was compiled revealing the need for improved and additional information, especially regarding energy consumption and efficiency. Drivers had difficulty understanding electrical units and the energy consumption of the BEV. On the background of general principles for display design, results provide implications how to display relevant information and how to facilitate drivers' understanding of energy consumption in BEVs. Practitioner Summary: Battery electric vehicle (BEV) displays need to incorporate new information. A taxonomy of user requirements was compiled revealing the need for improved and additional information in the BEV interface. Furthermore, drivers had trouble understanding electrical units and energy consumption; therefore, appropriate assistance is required. Design principles which are specifically important in the BEV context are discussed.

Background noise exerts diverse effects on the cortical encoding of foreground sounds.

PubMed

Malone, B J; Heiser, Marc A; Beitel, Ralph E; Schreiner, Christoph E

2017-08-01

In natural listening conditions, many sounds must be detected and identified in the context of competing sound sources, which function as background noise. Traditionally, noise is thought to degrade the cortical representation of sounds by suppressing responses and increasing response variability. However, recent studies of neural network models and brain slices have shown that background synaptic noise can improve the detection of signals. Because acoustic noise affects the synaptic background activity of cortical networks, it may improve the cortical responses to signals. We used spike train decoding techniques to determine the functional effects of a continuous white noise background on the responses of clusters of neurons in auditory cortex to foreground signals, specifically frequency-modulated sweeps (FMs) of different velocities, directions, and amplitudes. Whereas the addition of noise progressively suppressed the FM responses of some cortical sites in the core fields with decreasing signal-to-noise ratios (SNRs), the stimulus representation remained robust or was even significantly enhanced at specific SNRs in many others. Even though the background noise level was typically not explicitly encoded in cortical responses, significant information about noise context could be decoded from cortical responses on the basis of how the neural representation of the foreground sweeps was affected. These findings demonstrate significant diversity in signal in noise processing even within the core auditory fields that could support noise-robust hearing across a wide range of listening conditions. NEW & NOTEWORTHY The ability to detect and discriminate sounds in background noise is critical for our ability to communicate. The neural basis of robust perceptual performance in noise is not well understood. We identified neuronal populations in core auditory cortex of squirrel monkeys that differ in how they process foreground signals in background noise and that may contribute to robust signal representation and discrimination in acoustic environments with prominent background noise. Copyright © 2017 the American Physiological Society.

Data communication between data terminal equipment and the JPL administrative data base management system

NASA Technical Reports Server (NTRS)

Iverson, R. W.

1984-01-01

Approaches to enabling an installed base of mixed data terminal equipment to access a data base management system designed to work with a specific terminal are discussed. The approach taken by the Jet Propulsion Laboratory is described. Background information on the Jet Propulsion Laboratory (JPL), its organization and a description of the Administrative Data Base Management System is included.

Exploring the Impact of Individualism and Uncertainty Avoidance in Web-Based Electronic Learning: An Empirical Analysis in European Higher Education

ERIC Educational Resources Information Center

Sanchez-Franco, Manuel J.; Martinez-Lopez, Francisco J.; Martin-Velicia, Felix A.

2009-01-01

Our research specifically focuses on the effects of the national cultural background of educators on the acceptance and usage of ICT, particularly the Web as an extensive and expanding information base that provides the ultimate in resource-rich learning. Most research has been used North Americans as subjects. For this reason, we interviewed…

Deep space network: Mission support requirements

NASA Technical Reports Server (NTRS)

1991-01-01

The purpose is to provide NASA and Jet Propulsion Laboratory management with a concise summary of information concerning the forecasting of the necessary support and requirements for missions described here, including the Earth Radiation Budget Experiment, the Cosmic Background Explorer, the Comet Rendezvous Asteroid Flyby, the Cassini, and the Dynamics Explorer-1. A brief description of various missions along with specific support requirements for each are given.

Method for Establishing Direction of Arrival by Use of Signals of Opportunity

DTIC Science & Technology

2017-08-29

March 2018 The below identified patent application is available for licensing. Requests for information should be addressed to: TECHNOLOGY...without the payment of any royalties thereon or therefor. CROSS REFERENCE TO OTHER PATENT APPLICATIONS [0002] None. BACKGROUND OF THE INVENTION (1...based on a statistical model of a partitioned aperture communications receiving system and specifically a receiving system to converge on a best

Functional Assays for Ricin Detection

NASA Astrophysics Data System (ADS)

Ezan, Eric; Duriez, Elodie; Fenaille, François; Becher, François

In this review, we provide background information on ricin structure, present available functional assays for other toxins that are potential biothreat agents, and finish by describing the functional assay of ricin itself. Using appropriate sample preparation and optimized detection based on N-glycosidase activity, we demonstrate that specific detection of whole ricin at a level of around 0.1 ng/mL is possible and applicable to environmental samples.

The U.N. Population Fund: Background and the U.S. Funding Debate

DTIC Science & Technology

2008-07-24

provided $41 million specifically to procure contraceptive commodities. While UNFPA receives voluntary contributions from many countries — 180 in 2006...meeting unmet needs for contraceptive services; ! Supporting young people — providing accurate information, counseling, and services to prevent unwanted...services, postponing pregnancy for young girls, improving girls’ nutrition, and repairing physical and emotional damage. CRS-6 6 UNFPA. Annual Report

"Hook"-calibration of GeneChip-microarrays: theory and algorithm.

PubMed

Binder, Hans; Preibisch, Stephan

2008-08-29

: The improvement of microarray calibration methods is an essential prerequisite for quantitative expression analysis. This issue requires the formulation of an appropriate model describing the basic relationship between the probe intensity and the specific transcript concentration in a complex environment of competing interactions, the estimation of the magnitude these effects and their correction using the intensity information of a given chip and, finally the development of practicable algorithms which judge the quality of a particular hybridization and estimate the expression degree from the intensity values. : We present the so-called hook-calibration method which co-processes the log-difference (delta) and -sum (sigma) of the perfect match (PM) and mismatch (MM) probe-intensities. The MM probes are utilized as an internal reference which is subjected to the same hybridization law as the PM, however with modified characteristics. After sequence-specific affinity correction the method fits the Langmuir-adsorption model to the smoothed delta-versus-sigma plot. The geometrical dimensions of this so-called hook-curve characterize the particular hybridization in terms of simple geometric parameters which provide information about the mean non-specific background intensity, the saturation value, the mean PM/MM-sensitivity gain and the fraction of absent probes. This graphical summary spans a metrics system for expression estimates in natural units such as the mean binding constants and the occupancy of the probe spots. The method is single-chip based, i.e. it separately uses the intensities for each selected chip. : The hook-method corrects the raw intensities for the non-specific background hybridization in a sequence-specific manner, for the potential saturation of the probe-spots with bound transcripts and for the sequence-specific binding of specific transcripts. The obtained chip characteristics in combination with the sensitivity corrected probe-intensity values provide expression estimates scaled in natural units which are given by the binding constants of the particular hybridization.

The Cosmic Infrared Background Experiment (CIBER): A Sounding Rocket Payload to Study the near Infrared Extragalactic Background Light

NASA Astrophysics Data System (ADS)

Zemcov, M.; Arai, T.; Battle, J.; Bock, J.; Cooray, A.; Hristov, V.; Keating, B.; Kim, M. G.; Lee, D. H.; Levenson, L. R.; Mason, P.; Matsumoto, T.; Matsuura, S.; Nam, U. W.; Renbarger, T.; Sullivan, I.; Suzuki, K.; Tsumura, K.; Wada, T.

2013-08-01

The Cosmic Infrared Background Experiment (CIBER) is a suite of four instruments designed to study the near infrared (IR) background light from above the Earth's atmosphere. The instrument package comprises two imaging telescopes designed to characterize spatial anisotropy in the extragalactic IR background caused by cosmological structure during the epoch of reionization, a low resolution spectrometer to measure the absolute spectrum of the extragalactic IR background, and a narrow band spectrometer optimized to measure the absolute brightness of the zodiacal light foreground. In this paper we describe the design and characterization of the CIBER payload. The detailed mechanical, cryogenic, and electrical design of the system are presented, including all system components common to the four instruments. We present the methods and equipment used to characterize the instruments before and after flight, and give a detailed description of CIBER's flight profile and configurations. CIBER is designed to be recoverable and has flown four times, with modifications to the payload having been informed by analysis of the first flight data. All four instruments performed to specifications during the subsequent flights, and the scientific data from these flights are currently being analyzed.

THE COSMIC INFRARED BACKGROUND EXPERIMENT (CIBER): A SOUNDING ROCKET PAYLOAD TO STUDY THE NEAR INFRARED EXTRAGALACTIC BACKGROUND LIGHT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zemcov, M.; Bock, J.; Hristov, V.

2013-08-15

The Cosmic Infrared Background Experiment (CIBER) is a suite of four instruments designed to study the near infrared (IR) background light from above the Earth's atmosphere. The instrument package comprises two imaging telescopes designed to characterize spatial anisotropy in the extragalactic IR background caused by cosmological structure during the epoch of reionization, a low resolution spectrometer to measure the absolute spectrum of the extragalactic IR background, and a narrow band spectrometer optimized to measure the absolute brightness of the zodiacal light foreground. In this paper we describe the design and characterization of the CIBER payload. The detailed mechanical, cryogenic, andmore » electrical design of the system are presented, including all system components common to the four instruments. We present the methods and equipment used to characterize the instruments before and after flight, and give a detailed description of CIBER's flight profile and configurations. CIBER is designed to be recoverable and has flown four times, with modifications to the payload having been informed by analysis of the first flight data. All four instruments performed to specifications during the subsequent flights, and the scientific data from these flights are currently being analyzed.« less

Effects of background stimulation upon eye-movement information.

PubMed

Nakamura, S

1996-04-01

To investigate the effects of background stimulation upon eye-movement information (EMI), the perceived deceleration of the target motion during pursuit eye movement (Aubert-Fleishl paradox) was analyzed. In the experiment, a striped pattern was used as a background stimulus with various brightness contrasts and spatial frequencies for serially manipulating the attributions of the background stimulus. Analysis showed that the retinal-image motion of the background stimulus (optic flow) affected eye-movement information and that the effects of optic flow became stronger when high contrast and low spatial frequency stripes were presented as the background stimulus. In conclusion, optic flow is one source of eye-movement information in determining real object motion, and the effectiveness of optic flow depends on the attributes of the background stimulus.

Specific and diversive curiosity in gifted elementary students.

PubMed

Johnson, L; Beer, J

1992-10-01

Twenty-nine gifted students in Grades 2 to 6 from the small school districts in north central Kansas completed the Maze test and the Which-to-Discuss test. Background information such as age, sex, grade, and marital status of parents was also collected. There were no significant differences between boys and girls or for students from divorced and nondivorced parents on either the Which-to-Discuss test (specific curiosity) or the Maze test scores (diversive curiosity). The students scored significantly higher on the former test than chance guessing which suggests the students were displaying specific curiosity. Scores of these gifted students on these two tests of curiosity were significantly and positively correlated.

[On the Way to Culture-Sensitive Patient Information Materials: Results of a Focus Group Study].

PubMed

Ries, Zivile; Frank, Fabian; Bermejo, Isaac; Kalaitsidou, Chariklia; Zill, Jördis; Dirmaier, Jörg; Härter, Martin; Bengel, Jürgen; Hölzel, Lars

2018-06-01

This study was part of a double-blind randomised controlled trial aimed to evaluate the effects of culture-sensitive patient information materials (PIM) compared with standard translated material. The study aimed to obtain the data for the development of culture sensitive PIM about unipolar depression for the 4 largest migrant groups in Germany (Turkish, Polish, Russian and Italian migration background). A qualitative study using 4 manual-based focus groups (FG), one for each migrant group, with 29 participants (9 with a Turkish (TüG), 8 with a Polish (PoG), 5 with a Russian (RuG) and 7 with an Italian (ItG) migration background) was conducted. The discussions were recorded, transcribed and analyzed using qualitative content analysis. 7 categories were identified. For the (1.) development of a good culture-sensitive PIM an easy language, a clear structure, an assessable extent of information and the avoidance of stereotypes were highlighted cross-culturally in all four FG. RuG and PoG had the largest (2.) lack of information about the German health care system. Concerning the (3.) illness perception RuG named problems with recognizing and understanding depression. PoG, RuG and TüG thematized (4.) feared consequences of the illness and of professional helpseeking. ItG, PoG, RuG had fears concerning (5.) psychotropic drugs as a result from insufficient knowledge about medication. For (6.) doctor-patient relationship cultural specifics were identified in RuG and TüG and for (7.) migration or culture specific reasons for depression in RuG, ItG and TüG. Although the identified categories were relevant for all or for the majority of migrant groups, for most categories specific cultural aspects were discovered. These findings show the importance of a culture sensitive adaptation of PIM. © Georg Thieme Verlag KG Stuttgart · New York.

Effects of background motion on eye-movement information.

PubMed

Nakamura, S

1997-02-01

The effect of background stimulus on eye-movement information was investigated by analyzing the underestimation of the target velocity during pursuit eye movement (Aubert-Fleishl paradox). In the experiment, a striped pattern with various brightness contrasts and spatial frequencies was used as a background stimulus, which was moved at various velocities. Analysis showed that the perceived velocity of the pursuit target, which indicated the magnitudes of eye-movement information, decreased when the background stripes moved in the same direction as eye movement at higher velocities and increased when the background moved in the opposite direction. The results suggest that the eye-movement information varied as a linear function of the velocity of the motion of the background retinal image (optic flow). In addition, the effectiveness of optic flow on eye-movement information was determined by the attributes of the background stimulus such as the brightness contrast or the spatial frequency of the striped pattern.

Background Information and User Guide for MIL-F-8785C, Military Specification - Flying Qualities of Piloted Airplanes

DTIC Science & Technology

1982-07-01

Design Military Specification 20. ABSTRACT (Co.itInue o., revorse.• de if ,lec0O.•,•dr’ 1 Id•ntnify’’ bY bI. rk ,CI•,ti lim r) ’This document is published...criteria to Insert into the basic requirements, verification proceduresand leason: learned from past experience. The Standkerd will thus be the framework ...equations with sketch: Each of the three paired quantities in the de - nominators of KS and KR should have a hir over them, as is done in the numerators

Background Information and User’s Guide for MIL-F-9490

DTIC Science & Technology

1975-01-01

requirements, although different analysis results will apply to each requirement. Basic differences between the two realibility requirements are: MIL-F-8785B...provides the rationale for establishing such limits. The specific risk analysis comprises the same data which formed the average risk analysis , except...statistical analysis will be based on statistical data taken using limited exposure Limes of components and equipment. The exposure times and resulting

MissileLab User’s Guide

DTIC Science & Technology

2009-02-01

extension) that contain the airframe geometry specific to a single configuration. Results from a MissileLab run will be stored in a directory...re)created and contain all APE results and associated input files. C. Background In the early stages of missile system design, it is necessary to...Copying the AeroEngine Files After installation, the subdirectories in the “AeroEngine” directory contain contact information on how to obtain valid

Tobacco Talk: Educating Young Children about Tobacco. Suggestions for Teachers, Parents, and Other Care Providers of Children to Age 10.

ERIC Educational Resources Information Center

D'Onofrio, Carol

This book provides adults with specific suggestions and advice for talking with children about the health and social hazards of tobacco use. The first two chapters provide background information and general principles for talking about tobacco with children up to the age of 10. Each of the following five chapters focuses on one topic about tobacco…

Dynamics Explorer dual spacecraft to be launched on July 31

NASA Technical Reports Server (NTRS)

1981-01-01

Plans for the launch of the Dynamics Explorers A and B are announced. The mission of the spacecraft is described. Specific knowledge about the coupling of energy, electric currents, electric fields, and plasmas between the magnetosphere, the ionosphere, and the atmosphere is sought. The instrumentation of the spacecraft is described and the spacecraft and Delta 3918 launch vehicle characterized. Detailed background information amplifying the mission is included.

Apollo 17: At Taurus Littrow

NASA Technical Reports Server (NTRS)

Anderton, D. A.

1973-01-01

A summation, with color illustrations, is presented on the Apollo 17 mission. The height, weight, and thrust specifications are given on the launch vehicle. Presentations are given on: the night launch; earth to moon ascent; separation and descent; EVA, the sixth lunar surface expedition; ascent from Taurus-Littrow; the America to Challenger rendezvous; return, reentry, and recovery; the scientific results of the mission; background information on the astronauts; and the future projects.

Genome-wide prediction and analysis of human tissue-selective genes using microarray expression data

PubMed Central

2013-01-01

Background Understanding how genes are expressed specifically in particular tissues is a fundamental question in developmental biology. Many tissue-specific genes are involved in the pathogenesis of complex human diseases. However, experimental identification of tissue-specific genes is time consuming and difficult. The accurate predictions of tissue-specific gene targets could provide useful information for biomarker development and drug target identification. Results In this study, we have developed a machine learning approach for predicting the human tissue-specific genes using microarray expression data. The lists of known tissue-specific genes for different tissues were collected from UniProt database, and the expression data retrieved from the previously compiled dataset according to the lists were used for input vector encoding. Random Forests (RFs) and Support Vector Machines (SVMs) were used to construct accurate classifiers. The RF classifiers were found to outperform SVM models for tissue-specific gene prediction. The results suggest that the candidate genes for brain or liver specific expression can provide valuable information for further experimental studies. Our approach was also applied for identifying tissue-selective gene targets for different types of tissues. Conclusions A machine learning approach has been developed for accurately identifying the candidate genes for tissue specific/selective expression. The approach provides an efficient way to select some interesting genes for developing new biomedical markers and improve our knowledge of tissue-specific expression. PMID:23369200

Film/chemistry selection for the earth resources technology satellite /ERTS/ ground data handling system

NASA Technical Reports Server (NTRS)

Shaffer, R. M.

1973-01-01

A detailed description is given of the methods of choose the duplication film and chemistry currently used in the NASA-ERTS Ground Data Handling System. The major ERTS photographic duplication goals are given as background information to justify the specifications for the desirable film/chemistry combination. Once these specifications were defined, a quantitative evaluation program was designed and implemented to determine if any recommended combinations could meet the ERTS laboratory specifications. The specifications include tone reproduction, granularity, MTF and cosmetic effects. A complete description of the techniques used to measure the test response variables is given. It is anticipated that similar quantitative techniques could be used on other programs to determine the optimum film/chemistry consistent with the engineering goals of the program.

Imagery atlas: a structure of expert software designed to improve the accessibility of remote-sensed satellite imagery

NASA Astrophysics Data System (ADS)

Genet, Richard P.

1995-11-01

Policy changes in the United States and Europe will bring a number of firms into the remote sensing market. More importantly, there will be a vast increase in the amount of data and potentially, the amount of information, that is available for academic, commercial and a variety of public uses. Presently many of the users of remote sensing data have some understanding of photogrammetric and remote sensing technologies. This is especially true of environmentalist users and academics. As the amount of remote sensing data increases, in order to broaden the user base, it will become increasingly important that the information user not be required to have a background in photogrammetry, remote sensing, or even in the basics of geographic information systems. The user must be able to articulate his requirements in view of existence of new sources of information. This paper provides the framework for expert systems to accomplish this interface. Specific examples of the capabilities which must be developed in order to maximize the utility of specific images and image archives are presented and discussed.

Beyond the Classroom: The Impact of Informal STEM Experiences on Student Attitudes and Interest

NASA Astrophysics Data System (ADS)

Scinski, Lidia

A lack of social capital can be a critical factor impeding underrepresented minority (URM) students from obtaining the mathematical and scientific background required to achieve educational and career success in STEM fields. In this study, the effects of generating and utilizing social capital within an informal STEM outreach summer camp are examined as resources in strengthening the academic pipeline for Hispanic students towards careers in STEM. Empirical studies have shown that economically disadvantaged and minority students experience larger learning losses during "unschooled" periods of time than their middle-class and White counterparts. The "faucet theory" explains how the achievement gap widens during unschooled periods of time when the resource faucet is turned off and families of students from disadvantaged backgrounds are unable to make up for these resources. Consequently, minority and students of disadvantaged backgrounds are quickly shortcircuited in taking advantage of opportunities to pursue careers in STEM fields. To address the research questions, this study employed a qualitative research design, specifically an instrumental case study design using mixed methods within a bounded program. The methods included multiple measures to collect and analyze data from focus group interviews, electronic documents, observations, and survey administrations. The sample population included forty-nine Hispanic 7th and 8th grade students from middle schools in San Diego County. Results of the study demonstrated that the informal STEM outreach summer camp positively impacted Hispanic students and increased interest and attitudes toward STEM choices. STEM programs offered during out-of-school time need to be relationship based to support young students' social and emotional development (Goldstein, Lee, & Chung, 2010). The resource faucet continued to flow during the summer for iQUEST science camp participants because they were able to tap into social capital in the surrounding community. More specifically, participants were able to generate social capital in two key forms of institutional support: "funds of knowledge" and "emotional and moral support".

Neutral details associated with emotional events are encoded: evidence from a cued recall paradigm.

PubMed

Mickley Steinmetz, Katherine R; Knight, Aubrey G; Kensinger, Elizabeth A

2016-11-01

Enhanced emotional memory often comes at the cost of memory for surrounding background information. Narrowed-encoding theories suggest that this is due to narrowed attention for emotional information at encoding, leading to impaired encoding of background information. Recent work has suggested that an encoding-based theory may be insufficient. Here, we examined whether cued recall-instead of previously used recognition memory tasks-would reveal evidence that non-emotional information associated with emotional information was effectively encoded. Participants encoded positive, negative, or neutral objects on neutral backgrounds. At retrieval, they were given either the item or the background as a memory cue and were asked to recall the associated scene element. Counter to narrowed-encoding theories, emotional items were more likely than neutral items to trigger recall of the associated background. This finding suggests that there is a memory trace of this contextual information and that emotional cues may facilitate retrieval of this information.

Gender-Specific Determinants and Patterns of Online Health Information Seeking: Results From a Representative German Health Survey

PubMed Central

Baumann, Eva; Czerwinski, Fabian

2017-01-01

Background Online health information-seeking behavior (OHISB) is currently a widespread and common behavior that has been described as an important prerequisite of empowerment and health literacy. Although demographic factors such as socioeconomic status (SES), age, and gender have been identified as important determinants of OHISB, research is limited regarding the gender-specific motivational determinants of OHISB and differences between women and men in the use of online resources for health information purposes. Objective The aim of this study was to identify gender-specific determinants and patterns of OHISB by analyzing data from a representative German sample of adults (N=1728) with special attention to access and frequency of use as well as topics and sources of OHISB. Methods We employed a 2-step analysis, that is, after exploring differences between users and nonusers of online health information using logistic regression models, we highlighted gender-specific determinants of the frequency of OHISB by applying zero-truncated negative binomial models. Results Age (odds ratio, OR for females=0.97, 95% CI 0.96-0.99) and degree of satisfaction with one’s general practitioner (GP) (OR for males=0.73, 95% CI 0.57-0.92) were gender-specific determinants of access to OHISB. Regarding the frequency of OHISB, daily Internet use (incidence rate ratio, IRR=1.67, 95% CI 1.19-2.33) and a strong interest in health topics (IRR=1.45, 95% CI 1.19-1.77) were revealed to be more important predictors than SES (IRR for high SES=1.25, 95% CI 0.91-1.73). Conclusions Users indicate that the Internet seems to be capable of providing a valuable source of informational support and patient empowerment. Increasing the potential value of the Internet as a source for health literacy and patient empowerment requires need-oriented and gender-specific health communication efforts, media, and information strategies. PMID:28377367

The Mouse Tumor Biology Database: A Comprehensive Resource for Mouse Models of Human Cancer.

PubMed

Krupke, Debra M; Begley, Dale A; Sundberg, John P; Richardson, Joel E; Neuhauser, Steven B; Bult, Carol J

2017-11-01

Research using laboratory mice has led to fundamental insights into the molecular genetic processes that govern cancer initiation, progression, and treatment response. Although thousands of scientific articles have been published about mouse models of human cancer, collating information and data for a specific model is hampered by the fact that many authors do not adhere to existing annotation standards when describing models. The interpretation of experimental results in mouse models can also be confounded when researchers do not factor in the effect of genetic background on tumor biology. The Mouse Tumor Biology (MTB) database is an expertly curated, comprehensive compendium of mouse models of human cancer. Through the enforcement of nomenclature and related annotation standards, MTB supports aggregation of data about a cancer model from diverse sources and assessment of how genetic background of a mouse strain influences the biological properties of a specific tumor type and model utility. Cancer Res; 77(21); e67-70. ©2017 AACR . ©2017 American Association for Cancer Research.

A Computational Tool to Detect and Avoid Redundancy in Selected Reaction Monitoring

PubMed Central

Röst, Hannes; Malmström, Lars; Aebersold, Ruedi

2012-01-01

Selected reaction monitoring (SRM), also called multiple reaction monitoring, has become an invaluable tool for targeted quantitative proteomic analyses, but its application can be compromised by nonoptimal selection of transitions. In particular, complex backgrounds may cause ambiguities in SRM measurement results because peptides with interfering transitions similar to those of the target peptide may be present in the sample. Here, we developed a computer program, the SRMCollider, that calculates nonredundant theoretical SRM assays, also known as unique ion signatures (UIS), for a given proteomic background. We show theoretically that UIS of three transitions suffice to conclusively identify 90% of all yeast peptides and 85% of all human peptides. Using predicted retention times, the SRMCollider also simulates time-scheduled SRM acquisition, which reduces the number of interferences to consider and leads to fewer transitions necessary to construct an assay. By integrating experimental fragment ion intensities from large scale proteome synthesis efforts (SRMAtlas) with the information content-based UIS, we combine two orthogonal approaches to create high quality SRM assays ready to be deployed. We provide a user friendly, open source implementation of an algorithm to calculate UIS of any order that can be accessed online at http://www.srmcollider.org to find interfering transitions. Finally, our tool can also simulate the specificity of novel data-independent MS acquisition methods in Q1–Q3 space. This allows us to predict parameters for these methods that deliver a specificity comparable with that of SRM. Using SRM interference information in addition to other sources of information can increase the confidence in an SRM measurement. We expect that the consideration of information content will become a standard step in SRM assay design and analysis, facilitated by the SRMCollider. PMID:22535207

Chemical Source Localization Fusing Concentration Information in the Presence of Chemical Background Noise.

PubMed

Pomareda, Víctor; Magrans, Rudys; Jiménez-Soto, Juan M; Martínez, Dani; Tresánchez, Marcel; Burgués, Javier; Palacín, Jordi; Marco, Santiago

2017-04-20

We present the estimation of a likelihood map for the location of the source of a chemical plume dispersed under atmospheric turbulence under uniform wind conditions. The main contribution of this work is to extend previous proposals based on Bayesian inference with binary detections to the use of concentration information while at the same time being robust against the presence of background chemical noise. For that, the algorithm builds a background model with robust statistics measurements to assess the posterior probability that a given chemical concentration reading comes from the background or from a source emitting at a distance with a specific release rate. In addition, our algorithm allows multiple mobile gas sensors to be used. Ten realistic simulations and ten real data experiments are used for evaluation purposes. For the simulations, we have supposed that sensors are mounted on cars which do not have among its main tasks navigating toward the source. To collect the real dataset, a special arena with induced wind is built, and an autonomous vehicle equipped with several sensors, including a photo ionization detector (PID) for sensing chemical concentration, is used. Simulation results show that our algorithm, provides a better estimation of the source location even for a low background level that benefits the performance of binary version. The improvement is clear for the synthetic data while for real data the estimation is only slightly better, probably because our exploration arena is not able to provide uniform wind conditions. Finally, an estimation of the computational cost of the algorithmic proposal is presented.

Gaming for Safer Sex: Young German and Turkish People Report No Specific Culture-Related Preferences Toward Educational Games Promoting Safer Sex.

PubMed

Brüll, Phil; Ruiter, Robert A C; Wiers, Reinout W; Kok, Gerjo

2016-12-01

Comprehensive sex education programs specifically designed for adolescents and young adults that take into account gender norms and cultural background have shown promise as a means of countering the high sexually transmitted infection rate in young people. Recently, digital gaming interventions delivered on computers or mobile devices have emerged as another way to promote safer sex behavior in a young population. Tailoring these computer-based interventions to their target population has been recognized to increase positive behavior outcomes. In this qualitative study, we investigated whether young female and male adults from two different cultural backgrounds (all living in Germany) would have different preferences and needs in relation to an educational game promoting safer sex. We conducted four semistructured focus group interviews comprising open-ended questions with male and female participants who had either a German or a Turkish background. In total, 20 individuals, aged between 18 and 22 years, from two socially diverse and ethnically mixed vocational schools in Germany participated. Independent of cultural background and gender, participants preferred a real-world design with a first-person visual perspective over a fantasy-like third-person perspective. Furthermore, they preferred highly customizable avatars. All participants mentioned the importance of including an alcohol-intoxicated avatar and most participants wanted there to be additional information available about various safer sex approaches and about the use of different barrier protection methods. Males and females reported similar preferences for the design of an educational game promoting safer sex, with the only difference being exactly how the topic of having sexual intercourse should be addressed in the game. Males preferred a direct approach, whereas females had a preference for treating this subject more sympathetically. Educational games offer anonymity and can provide young people across different cultural backgrounds with gender-tailored opportunities to experiment with specific safer sex precautions in a nonthreatening virtual environment, free from unwanted parental control and peer monitoring.

New results and techniques in space radio astronomy.

NASA Technical Reports Server (NTRS)

Alexander, J. K.

1971-01-01

The methods and results of early space radioastronomy experiments are reviewed, with emphasis on the RAE 1 spacecraft which was designed specifically and exclusively for radio astronomical studies. The RAE 1 carries two gravity-gradient-stabilized 229-m traveling-wave V-antennas, a 37-m dipole antenna, and a number of radiometer systems to provide measurements over the 0.2 to 9.2 MHz frequency range with a time resolution of 0.5 sec and an absolute accuracy of plus or minus 25%. Observations of solar bursts at frequencies down to 0.2 MHz provide new information on the density, plasma velocity, and dynamics of coronal streamers out to distances greater than 50 solar radii. New information on the distribution of the ionized component of the interstellar medium is being obtained from galactic continuum background maps at frequencies around 4 MHz. Cosmic noise background spectra measured down to 0.5 MHz produce new estimates on the interstellar flux of cosmic rays, on magnetic fields in the galactic halo, and on distant extragalactic radio sources.

Health-Related Internet Use by Children and Adolescents: Systematic Review

PubMed Central

Kwon, Misol

2018-01-01

Background The internet is widely used by children and adolescents, who generally have a high level of competency with technology. Thus, the internet has become a great resource for supporting youth self-care and health-related services. However, few studies have explored adolescents’ internet use for health-related matters. Objective The objective of this systematic literature review was to examine the phenomenon of children and adolescents’ health-related internet use and to identify gaps in the research. Methods A total of 19 studies were selected from a search of major electronic databases: PubMed, Cumulative Index of Nursing and Allied Health Literature, and PsycINFO using the following search terms: “health-related internet use,” “eHealth,” “Internet use for health-related purpose,” “Web-based resource,” “health information seeking,” and “online resource,” combined with “child,” “adolescent,” “student,” “youth,” and “teen.” The children’s and adolescents’ ages were limited to 24 years and younger. The search was conducted from September 2015 to October 2017. The studies identified to contain youth (<24 years) health-related internet use were all published in peer-reviewed journals in the past 10 years; these studies examined general internet use seeking health care services, resources, information, or using the internet for health promotion and self-care. Studies were excluded if they explored the role of the internet as a modality for surveys, recruitment, or searching for relevant literature without specifically aiming to study participants’ health-related internet use; focused solely on quality assurance for specific websites; or were designed to test a specific internet-based intervention. Results Interesting patterns in adolescents’ health-related internet use, such as seeking preventative health care and specific information about medical issues, were identified. Quantitative studies reported rates of the internet use and access among youth, and the purpose and patterns of health-related internet use among youth were identified. A major objective of health-related internet use is to gain information, but there are inconsistencies in adolescents’ perceptions of health-related internet use. Conclusions This study’s findings provide important information on how youth seek information and related support systems for their health care on the internet. The conceptual and methodological limitations of the identified studies, such as the lack of a theoretical background and unrepresentative samples, are discussed, and gaps within the studies are identified for future research. This review also suggests important features for potential Web-based health interventions for children and adolescents. PMID:29615385

F-16 Training System Media Report

DTIC Science & Technology

1981-03-01

practice items. 4.1.3 Use/Procedure This strategy requires the learner to apply a set of sequential steps designed to accomplish a specific task which needs...information. 6. Feedback: Provides the student with the correct answers for the practice items. 4.1.5 Use/Rule This strategy requires the learner to...provide the background and rationale for selecting and/or modifying instructional media to best meet the needs of the F-16 training program. The

Integrating Research, Education, Outreach and Communication Through Storytelling: A Case Study in Progress

NASA Astrophysics Data System (ADS)

McCaffrey, M. S.; Ledley, T.; Manduca, C.; Salmon, R.

2006-12-01

In order to provide a meaningful context for non-technical users to be able to decipher and comprehend research data, it is necessary to provide background into the process involved. Storytelling can provide the narrative description that brings data alive by showing the 'Who' (providing human interest, education and training background, and career opportunities information), 'What' (focusing on discipline, field of study, research questions, and significance), 'Where' (geographic location(s), logistics involved in getting there, and elevation or depth), 'When' (time(s) of day, year data collected, and temporal scale data focus on), 'Why' (why is the data important intellectually as well as in the broader, societal context) and especially the 'How' (what tools, technology, mathematics, and statistics are used to collect, archive, and analyze data). The upcoming International Polar Year (IPY), running from March 2007 to March 2009, builds on prior polar research and IPYs, and offers a unique opportunity to showcase the process of data collection and analysis in a compelling human context. Internationally, the IPY Education, Outreach and Communication (EOC) subcommittee is seeking to integrate the EOC continuum and when appropriate repurpose information about specific research projects. For example, descriptions of projects designed initially for media purposes may also serve as the "at a glance" overview of a project that can then link to more detailed narrative descriptions of the projects, augmented with video and audio clips, web-links to related background information and relevant curriculum, and ultimately to the data itself, well scaffolded with relevant supporting materials and tools. In the United States, plans are underway for developing a suite of data stories that provide the narrative background of a project and can be used in museum kiosks and other informal science settings, data sheets, that provide teachers with an overview of the data, and curriculum and training for teachers using the model developed by the Earth Exploration Toolkit.

Domain-General Mechanisms for Speech Segmentation: The Role of Duration Information in Language Learning

PubMed Central

2016-01-01

Speech segmentation is supported by multiple sources of information that may either inform language processing specifically, or serve learning more broadly. The Iambic/Trochaic Law (ITL), where increased duration indicates the end of a group and increased emphasis indicates the beginning of a group, has been proposed as a domain-general mechanism that also applies to language. However, language background has been suggested to modulate use of the ITL, meaning that these perceptual grouping preferences may instead be a consequence of language exposure. To distinguish between these accounts, we exposed native-English and native-Japanese listeners to sequences of speech (Experiment 1) and nonspeech stimuli (Experiment 2), and examined segmentation using a 2AFC task. Duration was manipulated over 3 conditions: sequences contained either an initial-item duration increase, or a final-item duration increase, or items of uniform duration. In Experiment 1, language background did not affect the use of duration as a cue for segmenting speech in a structured artificial language. In Experiment 2, the same results were found for grouping structured sequences of visual shapes. The results are consistent with proposals that duration information draws upon a domain-general mechanism that can apply to the special case of language acquisition. PMID:27893268

Automatic Mechanisms for Social Attention Are Culturally Penetrable.

PubMed

Cohen, Adam S; Sasaki, Joni Y; German, Tamsin C; Kim, Heejung S

2017-01-01

Are mechanisms for social attention influenced by culture? Evidence that social attention is triggered automatically by bottom-up gaze cues and is uninfluenced by top-down verbal instructions may suggest it operates in the same way everywhere. Yet considerations from evolutionary and cultural psychology suggest that specific aspects of one's cultural background may have consequence for the way mechanisms for social attention develop and operate. In more interdependent cultures, the scope of social attention may be broader, focusing on more individuals and relations between those individuals. We administered a multi-gaze cueing task requiring participants to fixate a foreground face flanked by background faces and measured shifts in attention using eye tracking. For European Americans, gaze cueing did not depend on the direction of background gaze cues, suggesting foreground gaze alone drives automatic attention shifting; for East Asians, cueing patterns differed depending on whether the foreground cue matched or mismatched background cues, suggesting foreground and background gaze information were integrated. These results demonstrate that cultural background influences the social attention system by shifting it into a narrow or broad mode of operation and, importantly, provides evidence challenging the assumption that mechanisms underlying automatic social attention are necessarily rigid and impenetrable to culture. Copyright © 2015 Cognitive Science Society, Inc.

Initial Design of Culturally Informed Behavioral Intervention Technologies: Developing an mHealth Intervention for Young Sexual Minority Men With Generalized Anxiety Disorder and Major Depression

PubMed Central

Montague, Enid; Mohr, David C

2013-01-01

Background To our knowledge, there is no well-articulated process for the design of culturally informed behavioral intervention technologies. Objective This paper describes the early stages of such a process, illustrated by the methodology for the ongoing development of a behavioral intervention technology targeting generalized anxiety disorder and major depression among young sexual minority men. Methods We integrated instructional design for Internet behavioral intervention technologies with greater detail on information sources that can identify user needs in understudied populations, as well as advances in the understanding of technology-specific behavioral intervention technology dimensions that may need to be culturally tailored. Results General psychological theory describing how to effect change in the clinical target is first integrated with theory describing potentially malleable factors that help explain the clinical problem within the population. Additional information sources are then used to (1) evaluate the theory, (2) identify population-specific factors that may affect users’ ability to relate to and benefit from the behavioral intervention technology, and (3) establish specific skills, attitudes, knowledge, etc, required to change malleable factors posited in the theory. User needs result from synthesis of this information. Product requirements are then generated through application of the user needs to specific behavioral intervention technology dimensions (eg, technology platform). We provide examples of considerations relevant to each stage of this process and how they were applied. Conclusions This process can guide the initial design of other culturally informed behavioral intervention technologies. This first attempt to create a systematic design process can spur development of guidelines for design of behavioral intervention technologies aimed to reduce health disparities. PMID:24311444

Kepler Data Release 25 Notes (Q0-Q17)

NASA Technical Reports Server (NTRS)

Mullally, Susan E.; Caldwell, Douglas A.; Barclay, Thomas Stewart; Barentsen, Geert; Clarke, Bruce Donald; Bryson, Stephen T.; Burke, Christopher James; Campbell, Jennifer Roseanna; Catanzarite, Joseph H.; Christiansen, Jessie;

Prediction of Maternal Cytomegalovirus Serostatus in Early Pregnancy: A Retrospective Analysis in Western Europe

PubMed Central

Kuessel, Lorenz; Husslein, Heinrich; Marschalek, Julian; Brunner, Julia; Ristl, Robin; Popow-Kraupp, Theresia; Kiss, Herbert

2015-01-01

Background Cytomegalovirus (CMV) is the most prevalent congenital viral infection and thus places an enormous disease burden on newborn infants. Seroprevalence of maternal antibodies to CMV due to CMV exposure prior to pregnancy is currently the most important protective factor against congenital CMV disease. The aim of this study was to identify potential predictors, and to develop and evaluate a risk-predicting model for the maternal CMV serostatus in early pregnancy. Methods Maternal and paternal background information, as well as maternal CMV serostatus in early pregnancy from 882 pregnant women were analyzed. Women were divided into two groups based on their CMV serostatus, and were compared using univariate analysis. To predict serostatus based on epidemiological baseline characteristics, a multiple logistic regression model was calculated using stepwise model selection. Sensitivity and specificity were analyzed using ROC curves. A nomogram based on the model was developed. Results 646 women were CMV seropositive (73.2%), and 236 were seronegative (26.8%). The groups differed significantly with respect to maternal age (p = 0.006), gravidity (p<0.001), parity (p<0.001), use of assisted reproduction techniques (p = 0.018), maternal and paternal migration background (p<0.001), and maternal and paternal education level (p<0.001). ROC evaluation of the selected prediction model revealed an area under the curve of 0.83 (95%CI: 0.8–0.86), yielding sensitivity and specificity values of 0.69 and 0.86, respectively. Conclusion We identified predictors of maternal CMV serostatus in early pregnancy and developed a risk-predicting model based on baseline epidemiological characteristics. Our findings provide easy accessible information that can influence the counseling of pregnant woman in terms of their CMV-associated risk. PMID:26693714

The limits of arousal's memory impairing effects on nearby information

PubMed Central

Mather, Mara; Gorlick, Marissa; Nesmith, Kathryn

2009-01-01

Showing an arousing central stimulus in a scene often leads to enhanced memory for the arousing central information and impaired memory for peripheral details. However, it is not clear from previous work whether arousing stimuli impair memory for all non-arousing nearby information or just background information. In several experiments, we tested how emotionally arousing pictures affect memory for nearby pictures and for background information. We found that when two pictures were presented together, having one of the pictures be arousing did not affect item and location memory for the other picture. In contrast, an arousing picture impaired memory for a background pattern. These findings suggest that arousal impairs memory for information that is the target of perceptual suppression, such as background information when there is a figure-ground distinction, but does not impair memory for other foreground information. PMID:19827704

The limits of arousal's memory-impairing effects on nearby information.

PubMed

Mather, Mara; Gorlick, Marissa A; Nesmith, Kathryn

2009-01-01

Showing an arousing central stimulus in a scene often leads to enhanced memory for the arousing central information and impaired memory for peripheral details. However, it is not clear from previous work whether arousing stimuli impair memory for all nonarousing nearby information or just background information. In several experiments, we tested how emotionally arousing pictures affect memory for nearby pictures and for background information. We found that when 2 pictures were presented together, an arousing picture did not affect item and location memory for the other picture. In contrast, an arousing picture impaired memory for a background pattern. These findings suggest that arousal impairs memory for information that is the target of perceptual suppression, such as background information when there is a figure-ground distinction, but does not impair memory for other foreground information.

Neutral Details Associated with Emotional Events are Encoded: Evidence from a Cued Recall Paradigm

PubMed Central

Steinmetz, Katherine R. Mickley; Knight, Aubrey G.; Kensinger, Elizabeth A.

2015-01-01

Enhanced emotional memory often comes at the cost of memory for surrounding background information. Narrowed-encoding theories suggest that this is due to narrowed attention for emotional information at encoding, leading to impaired encoding of background information. Recent work has suggested that an encoding-based theory may be insufficient. Here, we examined whether cued recall – instead of previously used recognition memory tasks - would reveal evidence that non-emotional information associated with emotional information was effectively encoded. Participants encoded positive, negative, or neutral objects on neutral backgrounds. At retrieval, they were given either the item or the background as a memory cue and were asked to recall the associated scene element. Counter to narrowed-encoding theories, emotional items were more likely than neutral items to trigger recall of the associated background. This finding suggests that there is a memory trace of this contextual information and that emotional cues may facilitate retrieval of this information. PMID:26220708

Pigs in Toxicology: Breed Differences in Metabolism and Background Findings.

PubMed

Helke, Kristi L; Nelson, Keith N; Sargeant, Aaron M; Jacob, Binod; McKeag, Sean; Haruna, Julius; Vemireddi, Vimala; Greeley, Melanie; Brocksmith, Derek; Navratil, Nicole; Stricker-Krongrad, Alain; Hollinger, Charlotte

2016-06-01

Both a rodent and a nonrodent species are required for evaluation in nonclinical safety studies conducted to support human clinical trials. Historically, dogs and nonhuman primates have been the nonrodent species of choice. Swine, especially the miniature swine or minipigs, are increasingly being used in preclinical safety as an alternate nonrodent species. The pig is an appropriate option for these toxicology studies based on metabolic pathways utilized in xenobiotic biotransformation. Both similarities and differences exist in phase I and phase II biotransformation pathways between humans and pigs. There are numerous breeds of pigs, yet only a few of these breeds are characterized with regard to both xenobiotic-metabolizing enzymes and background pathology findings. Some specific differences in these enzymes based on breed and sex are known. Although swine have been used extensively in biomedical research, there is also a paucity of information in the current literature detailing the incidence of background lesions and differences between commonly used breeds. Here, the xenobiotic-metabolizing enzymes are compared between humans and pigs, and minipig background pathology changes are reviewed with emphasis on breed differences. © The Author(s) 2016.

Background sounds contribute to spectrotemporal plasticity in primary auditory cortex.

PubMed

Moucha, Raluca; Pandya, Pritesh K; Engineer, Navzer D; Rathbun, Daniel L; Kilgard, Michael P

2005-05-01

The mammalian auditory system evolved to extract meaningful information from complex acoustic environments. Spectrotemporal selectivity of auditory neurons provides a potential mechanism to represent natural sounds. Experience-dependent plasticity mechanisms can remodel the spectrotemporal selectivity of neurons in primary auditory cortex (A1). Electrical stimulation of the cholinergic nucleus basalis (NB) enables plasticity in A1 that parallels natural learning and is specific to acoustic features associated with NB activity. In this study, we used NB stimulation to explore how cortical networks reorganize after experience with frequency-modulated (FM) sweeps, and how background stimuli contribute to spectrotemporal plasticity in rat auditory cortex. Pairing an 8-4 kHz FM sweep with NB stimulation 300 times per day for 20 days decreased tone thresholds, frequency selectivity, and response latency of A1 neurons in the region of the tonotopic map activated by the sound. In an attempt to modify neuronal response properties across all of A1 the same NB activation was paired in a second group of rats with five downward FM sweeps, each spanning a different octave. No changes in FM selectivity or receptive field (RF) structure were observed when the neural activation was distributed across the cortical surface. However, the addition of unpaired background sweeps of different rates or direction was sufficient to alter RF characteristics across the tonotopic map in a third group of rats. These results extend earlier observations that cortical neurons can develop stimulus specific plasticity and indicate that background conditions can strongly influence cortical plasticity.

Background Signal as an in Situ Predictor of Dopamine Oxidation Potential: Improving Interpretation of Fast-Scan Cyclic Voltammetry Data.

PubMed

Meunier, Carl J; Roberts, James G; McCarty, Gregory S; Sombers, Leslie A

2017-02-15

Background-subtracted fast-scan cyclic voltammetry (FSCV) has emerged as a powerful analytical technique for monitoring subsecond molecular fluctuations in live brain tissue. Despite increasing utilization of FSCV, efforts to improve the accuracy of quantification have been limited due to the complexity of the technique and the dynamic recording environment. It is clear that variable electrode performance renders calibration necessary for accurate quantification; however, the nature of in vivo measurements can make conventional postcalibration difficult, or even impossible. Analyte-specific voltammograms and scaling factors that are critical for quantification can shift or fluctuate in vivo. This is largely due to impedance changes, and the effects of impedance on these measurements have not been characterized. We have previously reported that the background current can be used to predict electrode-specific scaling factors in situ. In this work, we employ model circuits to investigate the impact of impedance on FSCV measurements. Additionally, we take another step toward in situ electrode calibration by using the oxidation potential of quinones on the electrode surface to accurately predict the oxidation potential for dopamine at any point in an electrochemical experiment, as both are dependent on impedance. The model, validated both in adrenal slice and live brain tissue, enables information encoded in the shape of the background voltammogram to determine electrochemical parameters that are critical for accurate quantification. This improves data interpretation and provides a significant next step toward more automated methods for in vivo data analysis.

[Location information acquisition and sharing application design in national census of Chinese medicine resources].

PubMed

Zhang, Xiao-Bo; Li, Meng; Wang, Hui; Guo, Lan-Ping; Huang, Lu-Qi

2017-11-01

In literature, there are many information on the distribution of Chinese herbal medicine. Limited by the technical methods, the origin of Chinese herbal medicine or distribution of information in ancient literature were described roughly. It is one of the main objectives of the national census of Chinese medicine resources, which is the background information of the types and distribution of Chinese medicine resources in the region. According to the national Chinese medicine resource census technical specifications and pilot work experience, census team with "3S" technology, computer network technology, digital camera technology and other modern technology methods, can effectively collect the location information of traditional Chinese medicine resources. Detailed and specific location information, such as regional differences in resource endowment and similarity, biological characteristics and spatial distribution, the Chinese medicine resource census data access to the accuracy and objectivity evaluation work, provide technical support and data support. With the support of spatial information technology, based on location information, statistical summary and sharing of multi-source census data can be realized. The integration of traditional Chinese medicine resources and related basic data can be a spatial integration, aggregation and management of massive data, which can help for the scientific rules data mining of traditional Chinese medicine resources from the overall level and fully reveal its scientific connotation. Copyright© by the Chinese Pharmaceutical Association.

Optical switch probes and optical lock-in detection (OLID) imaging microscopy: high-contrast fluorescence imaging within living systems.

PubMed

Yan, Yuling; Marriott, M Emma; Petchprayoon, Chutima; Marriott, Gerard

2011-02-01

Few to single molecule imaging of fluorescent probe molecules can provide information on the distribution, dynamics, interactions and activity of specific fluorescently tagged proteins during cellular processes. Unfortunately, these imaging studies are made challenging in living cells because of fluorescence signals from endogenous cofactors. Moreover, related background signals within multi-cell systems and intact tissue are even higher and reduce signal contrast even for ensemble populations of probe molecules. High-contrast optical imaging within high-background environments will therefore require new ideas on the design of fluorescence probes, and the way their fluorescence signals are generated and analysed to form an image. To this end, in the present review we describe recent studies on a new family of fluorescent probe called optical switches, with descriptions of the mechanisms that underlie their ability to undergo rapid and reversible transitions between two distinct states. Optical manipulation of the fluorescent and non-fluorescent states of an optical switch probe generates a modulated fluorescence signal that can be isolated from a larger unmodulated background by using OLID (optical lock-in detection) techniques. The present review concludes with a discussion on select applications of synthetic and genetically encoded optical switch probes and OLID microscopy for high-contrast imaging of specific proteins and membrane structures within living systems.

Agricultural land cover mapping in the context of a geographically referenced digital information system. [Carroll, Macon, and Gentry Counties, Missouri

NASA Technical Reports Server (NTRS)

Stoner, E. R.

1982-01-01

The introduction of soil map information to the land cover mapping process can improve discrimination of land cover types and reduce confusion among crop types that may be caused by soil-specific management practices and background reflectance characteristics. Multiple dates of LANDSAT MSS digital were analyzed for three study areas in northern Missouri to produce cover types for major agricultural land cover classes. Digital data bases were then developed by adding ancillary data such as digitized soil and transportation network information to the LANDSAT-derived cover type map. Procedures were developed to manipulate the data base parameters to extract information applicable to user requirements. An agricultural information system combining such data can be used to determine the productive capacity of land to grow crops, fertilizer needs, chemical weed control rates, irrigation suitability, and trafficability of soil for planting.

Gene Function Hypotheses for the Campylobacter jejuni Glycome Generated by a Logic-Based Approach

PubMed Central

Sternberg, Michael J.E.; Tamaddoni-Nezhad, Alireza; Lesk, Victor I.; Kay, Emily; Hitchen, Paul G.; Cootes, Adrian; van Alphen, Lieke B.; Lamoureux, Marc P.; Jarrell, Harold C.; Rawlings, Christopher J.; Soo, Evelyn C.; Szymanski, Christine M.; Dell, Anne; Wren, Brendan W.; Muggleton, Stephen H.

2013-01-01

Increasingly, experimental data on biological systems are obtained from several sources and computational approaches are required to integrate this information and derive models for the function of the system. Here, we demonstrate the power of a logic-based machine learning approach to propose hypotheses for gene function integrating information from two diverse experimental approaches. Specifically, we use inductive logic programming that automatically proposes hypotheses explaining the empirical data with respect to logically encoded background knowledge. We study the capsular polysaccharide biosynthetic pathway of the major human gastrointestinal pathogen Campylobacter jejuni. We consider several key steps in the formation of capsular polysaccharide consisting of 15 genes of which 8 have assigned function, and we explore the extent to which functions can be hypothesised for the remaining 7. Two sources of experimental data provide the information for learning—the results of knockout experiments on the genes involved in capsule formation and the absence/presence of capsule genes in a multitude of strains of different serotypes. The machine learning uses the pathway structure as background knowledge. We propose assignments of specific genes to five previously unassigned reaction steps. For four of these steps, there was an unambiguous optimal assignment of gene to reaction, and to the fifth, there were three candidate genes. Several of these assignments were consistent with additional experimental results. We therefore show that the logic-based methodology provides a robust strategy to integrate results from different experimental approaches and propose hypotheses for the behaviour of a biological system. PMID:23103756

Gene function hypotheses for the Campylobacter jejuni glycome generated by a logic-based approach.

PubMed

Sternberg, Michael J E; Tamaddoni-Nezhad, Alireza; Lesk, Victor I; Kay, Emily; Hitchen, Paul G; Cootes, Adrian; van Alphen, Lieke B; Lamoureux, Marc P; Jarrell, Harold C; Rawlings, Christopher J; Soo, Evelyn C; Szymanski, Christine M; Dell, Anne; Wren, Brendan W; Muggleton, Stephen H

2013-01-09

Increasingly, experimental data on biological systems are obtained from several sources and computational approaches are required to integrate this information and derive models for the function of the system. Here, we demonstrate the power of a logic-based machine learning approach to propose hypotheses for gene function integrating information from two diverse experimental approaches. Specifically, we use inductive logic programming that automatically proposes hypotheses explaining the empirical data with respect to logically encoded background knowledge. We study the capsular polysaccharide biosynthetic pathway of the major human gastrointestinal pathogen Campylobacter jejuni. We consider several key steps in the formation of capsular polysaccharide consisting of 15 genes of which 8 have assigned function, and we explore the extent to which functions can be hypothesised for the remaining 7. Two sources of experimental data provide the information for learning-the results of knockout experiments on the genes involved in capsule formation and the absence/presence of capsule genes in a multitude of strains of different serotypes. The machine learning uses the pathway structure as background knowledge. We propose assignments of specific genes to five previously unassigned reaction steps. For four of these steps, there was an unambiguous optimal assignment of gene to reaction, and to the fifth, there were three candidate genes. Several of these assignments were consistent with additional experimental results. We therefore show that the logic-based methodology provides a robust strategy to integrate results from different experimental approaches and propose hypotheses for the behaviour of a biological system. Copyright © 2012 Elsevier Ltd. All rights reserved.

Does object view influence the scene consistency effect?

PubMed

Sastyin, Gergo; Niimi, Ryosuke; Yokosawa, Kazuhiko

2015-04-01

Traditional research on the scene consistency effect only used clearly recognizable object stimuli to show mutually interactive context effects for both the object and background components on scene perception (Davenport & Potter in Psychological Science, 15, 559-564, 2004). However, in real environments, objects are viewed from multiple viewpoints, including an accidental, hard-to-recognize one. When the observers named target objects in scenes (Experiments 1a and 1b, object recognition task), we replicated the scene consistency effect (i.e., there was higher accuracy for the objects with consistent backgrounds). However, there was a significant interaction effect between consistency and object viewpoint, which indicated that the scene consistency effect was more important for identifying objects in the accidental view condition than in the canonical view condition. Therefore, the object recognition system may rely more on the scene context when the object is difficult to recognize. In Experiment 2, the observers identified the background (background recognition task) while the scene consistency and object views were manipulated. The results showed that object viewpoint had no effect, while the scene consistency effect was observed. More specifically, the canonical and accidental views both equally provided contextual information for scene perception. These findings suggested that the mechanism for conscious recognition of objects could be dissociated from the mechanism for visual analysis of object images that were part of a scene. The "context" that the object images provided may have been derived from its view-invariant, relatively low-level visual features (e.g., color), rather than its semantic information.

Mars Sample Handling Protocol Workshop Series

NASA Technical Reports Server (NTRS)

Rummel, John D. (Editor); Race, Margaret S. (Editor); Acevedo, Sara (Technical Monitor)

2000-01-01

This document is the report resulting from the first workshop of the series on development of the criteria for a Mars sample handling protocol. Workshop 1 was held in Bethesda, Maryland on March 20-22, 2000. This report serves to document the proceedings of Workshop 1; it summarizes relevant background information, provides an overview of the deliberations to date, and helps frame issues that will need further attention or resolution in upcoming workshops. Specific recommendations are not part of this report.

[Migration and diabetes].

PubMed

Aydinkoc-Tuzcu, Kadriye; Schindler, Karin; Kautzky-Willer, Alexandra; Ludvik, Bernhard; Fasching, Peter

2016-04-01

The article deals with the demographic data of migration in Austria and with therapeutic advice concerning drug therapy and diabetes education for patients with migration background. In this context socio-cultural specifics are discussed. These suggestions are seen complementary to the general treatment guidelines of the Austrian Diabetes Association.Especially for the fast months Ramadan there are a lot of informations. The most important point is that the patient care must be highly individualized and the management plan may differ for each patient.

Evolution to Space

NASA Technical Reports Server (NTRS)

Cohen, Jacob

2013-01-01

This presentation will discuss recent space exploration results (LCROSS, KEPLER, etc.), increase access to space and the small and cube satellites platform as it relates to the future of space exploration. It will highlight the concept of modularization and the use of biology, and specifically synthetic biology in the future. The presentation will be a general public presentation. When speaking to a younger audience, I will discuss my background. All slides contain only public information. No technical ITAR/Export controlled material will be discussed.

The Institute of American Indian Arts Background Information (Task One of the Transition Evaluation). Background Paper.

ERIC Educational Resources Information Center

Tippeconnic, John W., Jr.

The paper, prepared as Task One of the Institute of American Indian Arts Transition Evaluation, provides pertinent background information about the Institute of American Indian Arts in Santa Fe, New Mexico. A brief history of the Institute is given, with information about its philosophy and purpose; objectives; organization and administration; the…

Prediction of TF target sites based on atomistic models of protein-DNA complexes

PubMed Central

Angarica, Vladimir Espinosa; Pérez, Abel González; Vasconcelos, Ana T; Collado-Vides, Julio; Contreras-Moreira, Bruno

2008-01-01

Background The specific recognition of genomic cis-regulatory elements by transcription factors (TFs) plays an essential role in the regulation of coordinated gene expression. Studying the mechanisms determining binding specificity in protein-DNA interactions is thus an important goal. Most current approaches for modeling TF specific recognition rely on the knowledge of large sets of cognate target sites and consider only the information contained in their primary sequence. Results Here we describe a structure-based methodology for predicting sequence motifs starting from the coordinates of a TF-DNA complex. Our algorithm combines information regarding the direct and indirect readout of DNA into an atomistic statistical model, which is used to estimate the interaction potential. We first measure the ability of our method to correctly estimate the binding specificities of eight prokaryotic and eukaryotic TFs that belong to different structural superfamilies. Secondly, the method is applied to two homology models, finding that sampling of interface side-chain rotamers remarkably improves the results. Thirdly, the algorithm is compared with a reference structural method based on contact counts, obtaining comparable predictions for the experimental complexes and more accurate sequence motifs for the homology models. Conclusion Our results demonstrate that atomic-detail structural information can be feasibly used to predict TF binding sites. The computational method presented here is universal and might be applied to other systems involving protein-DNA recognition. PMID:18922190

Central station market development strategies for photovoltaics

NASA Technical Reports Server (NTRS)

1980-01-01

Federal market development strategies designed to accelerate the market penetration of central station applications of photovoltaic energy system are analyzed. Since no specific goals were set for the commercialization of central station applications, strategic principles are explored which, when coupled with specific objectives for central stations, can produce a market development implementation plan. The study includes (1) background information on the National Photovoltaic Program, photovoltaic technology, and central stations; (2) a brief market assessment; (3) a discussion of the viewpoints of the electric utility industry with respect to solar energy; (4) a discussion of commercialization issues; and (5) strategy principles. It is recommended that a set of specific goals and objectives be defined for the photovoltaic central station program, and that these goals and objectives evolve into an implementation plan that identifies the appropriate federal role.

Central station market development strategies for photovoltaics

NASA Astrophysics Data System (ADS)

1980-11-01

Federal market development strategies designed to accelerate the market penetration of central station applications of photovoltaic energy system are analyzed. Since no specific goals were set for the commercialization of central station applications, strategic principles are explored which, when coupled with specific objectives for central stations, can produce a market development implementation plan. The study includes (1) background information on the National Photovoltaic Program, photovoltaic technology, and central stations; (2) a brief market assessment; (3) a discussion of the viewpoints of the electric utility industry with respect to solar energy; (4) a discussion of commercialization issues; and (5) strategy principles. It is recommended that a set of specific goals and objectives be defined for the photovoltaic central station program, and that these goals and objectives evolve into an implementation plan that identifies the appropriate federal role.

User perception and interpretation of tornado probabilistic hazard information: Comparison of four graphical designs.

PubMed

Miran, Seyed M; Ling, Chen; James, Joseph J; Gerard, Alan; Rothfusz, Lans

2017-11-01

Effective design for presenting severe weather information is important to reduce devastating consequences of severe weather. The Probabilistic Hazard Information (PHI) system for severe weather is being developed by NOAA National Severe Storms Laboratory (NSSL) to communicate probabilistic hazardous weather information. This study investigates the effects of four PHI graphical designs for tornado threat, namely, "four-color"," red-scale", "grayscale" and "contour", on users' perception, interpretation, and reaction to threat information. PHI is presented on either a map background or a radar background. Analysis showed that the accuracy was significantly higher and response time faster when PHI was displayed on map background as compared to radar background due to better contrast. When displayed on a radar background, "grayscale" design resulted in a higher accuracy of responses. Possibly due to familiarity, participants reported four-color design as their favorite design, which also resulted in the fastest recognition of probability levels on both backgrounds. Our study shows the importance of using intuitive color-coding and sufficient contrast in conveying probabilistic threat information via graphical design. We also found that users follows a rational perceiving-judging-feeling-and acting approach in processing probabilistic hazard information for tornado. Copyright © 2017 Elsevier Ltd. All rights reserved.

29 CFR Appendix A to §§ 1605.2 and... - Background Information

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 4 2010-07-01 2010-07-01 false Background Information A Appendix A to §§ 1605.2 and 1605... §§ 1605.2 and 1605.3—Background Information In 1966, the Commission adopted guidelines on religious... of Trans World Airlines' business, and would therefore, exceed the duty to accommodate Hardison. In...

29 CFR Appendix A to §§ 1605.2 and... - Background Information

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 4 2011-07-01 2011-07-01 false Background Information A Appendix A to §§ 1605.2 and 1605... §§ 1605.2 and 1605.3—Background Information In 1966, the Commission adopted guidelines on religious... of Trans World Airlines' business, and would therefore, exceed the duty to accommodate Hardison. In...

Evaluation as a critical factor of success in local public health accreditation programs.

PubMed

Tremain, Beverly; Davis, Mary; Joly, Brenda; Edgar, Mark; Kushion, Mary L; Schmidt, Rita

2007-01-01

This article presents the variety of approaches used to conduct evaluations of performance improvement or accreditation systems, while illustrating the complexity of conducting evaluations to inform local public health practice. We, in addition, hope to inform the Exploring Accreditation Program about relevant experiences involving accreditation and performance assessment processes, specifically evaluation, as it debates and discusses a national voluntary model. A background of each state is given. To further explore these issues, interviews were conducted with each state's evaluator to gain more in-depth information on the many different evaluation strategies and approaches used. On the basis of the interviews, the authors provide several overall themes, which suggest that evaluation is a critical tool and success factor for performance assessment or accreditation programs.

Integrating GPCR-specific information with full text articles

PubMed Central

2011-01-01

Background With the continued growth in the volume both of experimental G protein-coupled receptor (GPCR) data and of the related peer-reviewed literature, the ability of GPCR researchers to keep up-to-date is becoming increasingly curtailed. Results We present work that integrates the biological data and annotations in the GPCR information system (GPCRDB) with next-generation methods for intelligently exploring, visualising and interacting with the scientific articles used to disseminate them. This solution automatically retrieves relevant information from GPCRDB and displays it both within and as an adjunct to an article. Conclusions This approach allows researchers to extract more knowledge more swiftly from literature. Importantly, it allows reinterpretation of data in articles published before GPCR structure data became widely available, thereby rescuing these valuable data from long-dormant sources. PMID:21910883

Optical polarization: background and camouflage

NASA Astrophysics Data System (ADS)

Škerlind, Christina; Hallberg, Tomas; Eriksson, Johan; Kariis, Hans; Bergström, David

2017-10-01

Polarimetric imaging sensors in the electro-optical region, already military and commercially available in both the visual and infrared, show enhanced capabilities for advanced target detection and recognition. The capabilities arise due to the ability to discriminate between man-made and natural background surfaces using the polarization information of light. In the development of materials for signature management in the visible and infrared wavelength regions, different criteria need to be met to fulfil the requirements for a good camouflage against modern sensors. In conventional camouflage design, the aimed design of the surface properties of an object is to spectrally match or adapt it to a background and thereby minimizing the contrast given by a specific threat sensor. Examples will be shown from measurements of some relevant materials and how they in different ways affect the polarimetric signature. Dimensioning properties relevant in an optical camouflage from a polarimetric perspective, such as degree of polarization, the viewing or incident angle, and amount of diffuse reflection, mainly in the infrared region, will be discussed.

[Culture sensitive analysis of psychosomatic complaints in migrants in Germany].

PubMed

Bermejo, Isaac; Nicolaus, Leonhard; Kriston, Levente; Hölzel, Lars; Härter, Martin

2012-05-01

To ensure an adequate health care of migrants, differentiated information on the association of cultural background and migration related factors and psychosomatic complaints are necessary. Cross-sectional questionnaire based survey regarding psychosomatic complaints of migrants from Turkey (n = 77), Italy (n = 95), and Spain (n = 67) and ethnic German resettled from the states of the former Soviet Union (n = 196). Questionnaires distributed by non-health specific counselling agencies of welfare associations. The cultural background was a relevant factor for psychosomatic complaints, showing higher complaints in Turkish and ethnic German resettled migrants, also compared to a sample of age corresponding Germans. In contrast, Spanish and Italian migrants showed a lower risk for psychosomatic complaints. Also gender, feeling unwell in Germany and fatalism showed a significant association with psychosomatic complaints. Migrants in Germany do not have per se a higher risk for psychosomatic complaints. A distinct differentiation by cultural background is necessary. © Georg Thieme Verlag KG Stuttgart · New York.

76 FR 34639 - Notice of Proposed Additional Information Collection: Advisory Committee and Research and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-14

... and Research and Promotion Background Information AGENCY: Office of the Secretary, USDA. ACTION... and Promotion Background Information to include Race, Ethnicity, National Origin, Gender and...: [email protected] . SUPPLEMENTARY INFORMATION: Title: Advisory Committee and Research and Promotion...

Aerial thermography for energy conservation

NASA Technical Reports Server (NTRS)

Jack, J. R.

1978-01-01

Thermal infrared scanning from an aircraft is a convenient and commercially available means for determining relative rates of energy loss from building roofs. The need to conserve energy as fuel costs makes the mass survey capability of aerial thermography an attractive adjunct to community energy awareness programs. Background information on principles of aerial thermography is presented. Thermal infrared scanning systems, flight and environmental requirements for data acquisition, preparation of thermographs for display, major users and suppliers of thermography, and suggested specifications for obtaining aerial scanning services were reviewed.

Accommodating complexity and human behaviors in decision analysis.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Backus, George A.; Siirola, John Daniel; Schoenwald, David Alan

2007-11-01

This is the final report for a LDRD effort to address human behavior in decision support systems. One sister LDRD effort reports the extension of this work to include actual human choices and additional simulation analyses. Another provides the background for this effort and the programmatic directions for future work. This specific effort considered the feasibility of five aspects of model development required for analysis viability. To avoid the use of classified information, healthcare decisions and the system embedding them became the illustrative example for assessment.

76 FR 30405 - Information Collection Request Under OMB Review

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-25

..., the National Agency Check (NAC) Questionnaire for Peace Corps Volunteer Background Investigation (OMB... INFORMATION: The NAC Questionnaire for Peace Corps Volunteer Background Investigation Form is used to conduct... Volunteer Background Investigation. Type of Review: Reinstatement, without change, of a previously approved...

Thresholding of auditory cortical representation by background noise

PubMed Central

Liang, Feixue; Bai, Lin; Tao, Huizhong W.; Zhang, Li I.; Xiao, Zhongju

2014-01-01

It is generally thought that background noise can mask auditory information. However, how the noise specifically transforms neuronal auditory processing in a level-dependent manner remains to be carefully determined. Here, with in vivo loose-patch cell-attached recordings in layer 4 of the rat primary auditory cortex (A1), we systematically examined how continuous wideband noise of different levels affected receptive field properties of individual neurons. We found that the background noise, when above a certain critical/effective level, resulted in an elevation of intensity threshold for tone-evoked responses. This increase of threshold was linearly dependent on the noise intensity above the critical level. As such, the tonal receptive field (TRF) of individual neurons was translated upward as an entirety toward high intensities along the intensity domain. This resulted in preserved preferred characteristic frequency (CF) and the overall shape of TRF, but reduced frequency responding range and an enhanced frequency selectivity for the same stimulus intensity. Such translational effects on intensity threshold were observed in both excitatory and fast-spiking inhibitory neurons, as well as in both monotonic and nonmonotonic (intensity-tuned) A1 neurons. Our results suggest that in a noise background, fundamental auditory representations are modulated through a background level-dependent linear shifting along intensity domain, which is equivalent to reducing stimulus intensity. PMID:25426029

76 FR 69287 - National Instant Criminal Background Check System Section Agency Information Collection...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-08

... System Section Agency Information Collection Activities: Existing collection, comments requested the Voluntary Appeal File (VAF) Brochure ACTION: 60-Day Notice of Information Collection Under Review. The... Criminal Background Check System (NICS) Section has submitted the following information collection request...

Human face detection using motion and color information

NASA Astrophysics Data System (ADS)

Kim, Yang-Gyun; Bang, Man-Won; Park, Soon-Young; Choi, Kyoung-Ho; Hwang, Jeong-Hyun

2008-02-01

In this paper, we present a hardware implementation of a face detector for surveillance applications. To come up with a computationally cheap and fast algorithm with minimal memory requirement, motion and skin color information are fused successfully. More specifically, a newly appeared object is extracted first by comparing average Hue and Saturation values of background image and a current image. Then, the result of skin color filtering of the current image is combined with the result of a newly appeared object. Finally, labeling is performed to locate a true face region. The proposed system is implemented on Altera Cyclone2 using Quartus II 6.1 and ModelSim 6.1. For hardware description language (HDL), Verilog-HDL is used.

INFORMATIONAL STRESS AS A DEPRESSION INDUCING FACTOR (EXPERIMENTAL STUDY).

PubMed

Matitaishvili, T; Domianidze, T; Burdjanadze, G; Nadareishvili, D; Khananashvili, M

2017-01-01

Chronic psychogenic stress represents the major initiating agent of psychoneural diseases including depression. We used informational stress model for the purpose of modelling chronic psychogenic stress and depression. The aim of the research was to study behavior of dominant and submissive rats at different stages of informational stress and during depression state. In order to study anxiety and depressive behavior of rats we used "forced swim", "elevated cross maze" and "open-field" tests. The obtained results showed that chronic stressing procedure performed on rats by using the mentioned "informational" stress model led to the development of depression both in dominant and submissive rats. Stressing procedure caused sharp increase of serotonin concentration in hypothalamus of dominant and submissive rats. Under behavioral depression background, sharp increase of serotonin concentration in hypothalamus has been revealed which is caused by the peculiarities of stress model (by uncontrollable stressor. Specifically, by inevitable electric painful irritation).

Health Insurance Portability and Accountability Act (HIPAA) Privacy Rule and the National Instant Criminal Background Check System (NICS). Final rule.

PubMed

2016-01-06

The Department of Health and Human Services (HHS or "the Department'') is issuing this final rule to modify the Health Insurance Portability and Accountability Act of 1996 (HIPAA) Privacy Rule to expressly permit certain HIPAA covered entities to disclose to the National Instant Criminal Background Check System (NICS) the identities of individuals who are subject to a Federal "mental health prohibitor'' that disqualifies them from shipping, transporting, possessing, or receiving a firearm. The NICS is a national system maintained by the Federal Bureau of Investigation (FBI) to conduct background checks on persons who may be disqualified from receiving firearms based on Federally prohibited categories or State law. Among the persons subject to the Federal mental health prohibitor established under the Gun Control Act of 1968 and implementing regulations issued by the Department of Justice (DOJ) are individuals who have been involuntarily committed to a mental institution; found incompetent to stand trial or not guilty by reason of insanity; or otherwise have been determined by a court, board, commission, or other lawful authority to be a danger to themselves or others or to lack the mental capacity to contract or manage their own affairs, as a result of marked subnormal intelligence or mental illness, incompetency, condition, or disease. Under this final rule, only covered entities with lawful authority to make the adjudications or commitment decisions that make individuals subject to the Federal mental health prohibitor, or that serve as repositories of information for NICS reporting purposes, are permitted to disclose the information needed for these purposes. The disclosure is restricted to limited demographic and certain other information needed for NICS purposes. The rule specifically prohibits the disclosure of diagnostic or clinical information, from medical records or other sources, and any mental health information beyond the indication that the individual is subject to the Federal mental health prohibitor.

Parametric models to relate spike train and LFP dynamics with neural information processing.

PubMed

Banerjee, Arpan; Dean, Heather L; Pesaran, Bijan

2012-01-01

Spike trains and local field potentials (LFPs) resulting from extracellular current flows provide a substrate for neural information processing. Understanding the neural code from simultaneous spike-field recordings and subsequent decoding of information processing events will have widespread applications. One way to demonstrate an understanding of the neural code, with particular advantages for the development of applications, is to formulate a parametric statistical model of neural activity and its covariates. Here, we propose a set of parametric spike-field models (unified models) that can be used with existing decoding algorithms to reveal the timing of task or stimulus specific processing. Our proposed unified modeling framework captures the effects of two important features of information processing: time-varying stimulus-driven inputs and ongoing background activity that occurs even in the absence of environmental inputs. We have applied this framework for decoding neural latencies in simulated and experimentally recorded spike-field sessions obtained from the lateral intraparietal area (LIP) of awake, behaving monkeys performing cued look-and-reach movements to spatial targets. Using both simulated and experimental data, we find that estimates of trial-by-trial parameters are not significantly affected by the presence of ongoing background activity. However, including background activity in the unified model improves goodness of fit for predicting individual spiking events. Uncovering the relationship between the model parameters and the timing of movements offers new ways to test hypotheses about the relationship between neural activity and behavior. We obtained significant spike-field onset time correlations from single trials using a previously published data set where significantly strong correlation was only obtained through trial averaging. We also found that unified models extracted a stronger relationship between neural response latency and trial-by-trial behavioral performance than existing models of neural information processing. Our results highlight the utility of the unified modeling framework for characterizing spike-LFP recordings obtained during behavioral performance.

PTBS segmentation scheme for synthetic aperture radar

NASA Astrophysics Data System (ADS)

Friedland, Noah S.; Rothwell, Brian J.

1995-07-01

The Image Understanding Group at Martin Marietta Technologies in Denver, Colorado has developed a model-based synthetic aperture radar (SAR) automatic target recognition (ATR) system using an integrated resource architecture (IRA). IRA, an adaptive Markov random field (MRF) environment, utilizes information from image, model, and neighborhood resources to create a discrete, 2D feature-based world description (FBWD). The IRA FBWD features are peak, target, background and shadow (PTBS). These features have been shown to be very useful for target discrimination. The FBWD is used to accrue evidence over a model hypothesis set. This paper presents the PTBS segmentation process utilizing two IRA resources. The image resource (IR) provides generic (the physics of image formation) and specific (the given image input) information. The neighborhood resource (NR) provides domain knowledge of localized FBWD site behaviors. A simulated annealing optimization algorithm is used to construct a `most likely' PTBS state. Results on simulated imagery illustrate the power of this technique to correctly segment PTBS features, even when vehicle signatures are immersed in heavy background clutter. These segmentations also suppress sidelobe effects and delineate shadows.

Neutral location cues and cost/benefit analysis of visual attention shifts.

PubMed

Wright, R D; Richard, C M; McDonald, J J

1995-12-01

The effects of location cuing on target responses can be examined by comparing informative and neutral cuing conditions. In particular, the magnitudes of costs of invalid location cuing and of benefits of valid location cuing can be determined by comparing invalid and valid cue responses to location-nonspecific neutral cue responses. Cost/benefit analysis is based on the assumption that neutral baseline measures reflect a general warning effect about the impending target's onset but no other specific target information. The experiments we report were carried out to determine the appropriateness of two baseline measures for cost/benefit analyses of direct (nonsymbolic) location cuing effects. We found that a multiple-cue baseline attenuated the benefits of valid cuing, and that a background-flash baseline arbitrarily attenuated costs or benefits depending on flash intensity. It is proposed that a background flash is the more suitable neutral cue because it is target-location-nonspecific, but that its intensity should be adjusted to elicit a target-onset warning signal of the same magnitude as the location cues with which it will be compared.

Background sounds contribute to spectrotemporal plasticity in primary auditory cortex

PubMed Central

Moucha, Raluca; Pandya, Pritesh K.; Engineer, Navzer D.; Rathbun, Daniel L.

2010-01-01

The mammalian auditory system evolved to extract meaningful information from complex acoustic environments. Spectrotemporal selectivity of auditory neurons provides a potential mechanism to represent natural sounds. Experience-dependent plasticity mechanisms can remodel the spectrotemporal selectivity of neurons in primary auditory cortex (A1). Electrical stimulation of the cholinergic nucleus basalis (NB) enables plasticity in A1 that parallels natural learning and is specific to acoustic features associated with NB activity. In this study, we used NB stimulation to explore how cortical networks reorganize after experience with frequency-modulated (FM) sweeps, and how background stimuli contribute to spectrotemporal plasticity in rat auditory cortex. Pairing an 8–4 kHz FM sweep with NB stimulation 300 times per day for 20 days decreased tone thresholds, frequency selectivity, and response latency of A1 neurons in the region of the tonotopic map activated by the sound. In an attempt to modify neuronal response properties across all of A1 the same NB activation was paired in a second group of rats with five downward FM sweeps, each spanning a different octave. No changes in FM selectivity or receptive field (RF) structure were observed when the neural activation was distributed across the cortical surface. However, the addition of unpaired background sweeps of different rates or direction was sufficient to alter RF characteristics across the tonotopic map in a third group of rats. These results extend earlier observations that cortical neurons can develop stimulus specific plasticity and indicate that background conditions can strongly influence cortical plasticity PMID:15616812

77 FR 66634 - Agency Information Collection Activities: Proposed Collection; Comments Requested: Appeals of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-06

...] Agency Information Collection Activities: Proposed Collection; Comments Requested: Appeals of Background... Information Collection (1) Type of Information Collection: Extension of a currently approved collection. (2) Title of the Form/Collection: Appeals of Background Checks. (3) Agency form number, if any, and the...

Patient-Reported Outcome (PRO) Assessment in Clinical Trials: A Systematic Review of Guidance for Trial Protocol Writers

PubMed Central

Calvert, Melanie; Kyte, Derek; Duffy, Helen; Gheorghe, Adrian; Mercieca-Bebber, Rebecca; Ives, Jonathan; Draper, Heather; Brundage, Michael; Blazeby, Jane; King, Madeleine

2014-01-01

Background Evidence suggests there are inconsistencies in patient-reported outcome (PRO) assessment and reporting in clinical trials, which may limit the use of these data to inform patient care. For trials with a PRO endpoint, routine inclusion of key PRO information in the protocol may help improve trial conduct and the reporting and appraisal of PRO results; however, it is currently unclear exactly what PRO-specific information should be included. The aim of this review was to summarize the current PRO-specific guidance for clinical trial protocol developers. Methods and Findings We searched the MEDLINE, EMBASE, CINHAL and Cochrane Library databases (inception to February 2013) for PRO-specific guidance regarding trial protocol development. Further guidance documents were identified via Google, Google scholar, requests to members of the UK Clinical Research Collaboration registered clinical trials units and international experts. Two independent investigators undertook title/abstract screening, full text review and data extraction, with a third involved in the event of disagreement. 21,175 citations were screened and 54 met the inclusion criteria. Guidance documents were difficult to access: electronic database searches identified just 8 documents, with the remaining 46 sourced elsewhere (5 from citation tracking, 27 from hand searching, 7 from the grey literature review and 7 from experts). 162 unique PRO-specific protocol recommendations were extracted from included documents. A further 10 PRO recommendations were identified relating to supporting trial documentation. Only 5/162 (3%) recommendations appeared in ≥50% of guidance documents reviewed, indicating a lack of consistency. Conclusions PRO-specific protocol guidelines were difficult to access, lacked consistency and may be challenging to implement in practice. There is a need to develop easily accessible consensus-driven PRO protocol guidance. Guidance should be aimed at ensuring key PRO information is routinely included in appropriate trial protocols, in order to facilitate rigorous collection/reporting of PRO data, to effectively inform patient care. PMID:25333995

78 FR 70070 - Agency Information Collection Activities; Proposed Collection; Comments Requested: Request for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-22

... Background Investigation Information ACTION: 30-Day notice. The Department of Justice (DOJ), Bureau of... the burden of the proposed collection of information, including the validity of the methodology and... Form/Collection: Request for ATF Background Investigation Information. (3) Agency form number, if any...

Dark matter vs. neutrinos: the effect of astrophysical uncertainties and timing information on the neutrino floor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davis, Jonathan H., E-mail: jonathan.h.m.davis@gmail.com

2015-03-01

Future multi-tonne Direct Detection experiments will be sensitive to solar neutrino induced nuclear recoils which form an irreducible background to light Dark Matter searches. Indeed for masses around 6 GeV the spectra of neutrinos and Dark Matter are so similar that experiments are said to run into a neutrino floor, for which sensitivity increases only marginally with exposure past a certain cross section. In this work we show that this floor can be overcome using the different annual modulation expected from solar neutrinos and Dark Matter. Specifically for cross sections below the neutrino floor the DM signal is observable throughmore » a phase shift and a smaller amplitude for the time-dependent event rate. This allows the exclusion power to be improved by up to an order of magnitude for large exposures. In addition we demonstrate that, using only spectral information, the neutrino floor exists over a wider mass range than has been previously shown, since the large uncertainties in the Dark Matter velocity distribution make the signal spectrum harder to distinguish from the neutrino background. However for most velocity distributions it can still be surpassed using timing information, and so the neutrino floor is not an absolute limit on the sensitivity of Direct Detection experiments.« less

Dark matter vs. neutrinos: the effect of astrophysical uncertainties and timing information on the neutrino floor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davis, Jonathan H.

2015-03-09

Future multi-tonne Direct Detection experiments will be sensitive to solar neutrino induced nuclear recoils which form an irreducible background to light Dark Matter searches. Indeed for masses around 6 GeV the spectra of neutrinos and Dark Matter are so similar that experiments are said to run into a neutrino floor, for which sensitivity increases only marginally with exposure past a certain cross section. In this work we show that this floor can be overcome using the different annual modulation expected from solar neutrinos and Dark Matter. Specifically for cross sections below the neutrino floor the DM signal is observable throughmore » a phase shift and a smaller amplitude for the time-dependent event rate. This allows the exclusion power to be improved by up to an order of magnitude for large exposures. In addition we demonstrate that, using only spectral information, the neutrino floor exists over a wider mass range than has been previously shown, since the large uncertainties in the Dark Matter velocity distribution make the signal spectrum harder to distinguish from the neutrino background. However for most velocity distributions it can still be surpassed using timing information, and so the neutrino floor is not an absolute limit on the sensitivity of Direct Detection experiments.« less

[Effects of exposure frequency and background information on preferences for photographs of cars in different locations].

PubMed

Matsuda, Ken; Kusumi, Takashi; Hosomi, Naohiro; Osa, Atsushi; Miike, Hidetoshi

2014-08-01

This study examined the influence of familiarity and novelty on the mere exposure effect while manipulating the presentation of background information. We selected presentation stimuli that integrated cars and backgrounds based on the results of pilot studies. During the exposure phase, we displayed the stimuli successively for 3 seconds, manipulating the background information (same or different backgrounds with each presentation) and exposure frequency (3, 6, and 9 times). In the judgment phase, 18 participants judged the cars in terms of preference, familiarity, and novelty on a 7-point scale. As the number of stimulus presentations increased, the preference for the cars increased during the different background condition and decreased during the same background condition. This increased preference may be due to the increase in familiarity caused by the higher exposure frequency and novelty resulting from the background changes per exposure session. The rise in preference judgments was not seen when cars and backgrounds were presented independently. Therefore, the addition of novel features to each exposure session facilitated the mere exposure effect.

Mathematics teachers' support and retention: using Maslow's hierarchy to understand teachers' needs

NASA Astrophysics Data System (ADS)

Fisher, Molly H.; Royster, David

2016-10-01

As part of a larger study, four mathematics teachers from diverse backgrounds and teaching situations report their ideas on teacher stress, mathematics teacher retention, and their feelings about the needs of mathematics teachers, as well as other information crucial to retaining quality teachers. The responses from the participants were used to develop a hierarchy of teachers' needs that resembles Maslow's hierarchy, which can be used to better support teachers in various stages of their careers. The interviews revealed both non content-specific and content-specific needs within the hierarchy. The responses show that teachers found different schools foster different stress levels and that as teachers they used a number of resources for reducing stress. Other mathematics-specific ideas are also discussed such as the amount of content and pedagogy courses required for certification.

Rapid Decision-Making with Side-Specific Perceptual Discrimination in Ants

PubMed Central

Stroeymeyt, Nathalie; Guerrieri, Fernando J.; van Zweden, Jelle S.; d'Ettorre, Patrizia

2010-01-01

Background Timely decision making is crucial for survival and reproduction. Organisms often face a speed-accuracy trade-off, as fully informed, accurate decisions require time-consuming gathering and treatment of information. Optimal strategies for decision-making should therefore vary depending on the context. In mammals, there is mounting evidence that multiple systems of perceptual discrimination based on different neural circuits emphasize either fast responses or accurate treatment of stimuli depending on the context. Methodology/Principal Findings We used the ant Camponotus aethiops to test the prediction that fast information processing achieved through direct neural pathways should be favored in situations where quick reactions are adaptive. Social insects discriminate readily between harmless group-members and dangerous strangers using easily accessible cuticular hydrocarbons as nestmate recognition cues. We show that i) tethered ants display rapid aggressive reactions upon presentation of non-nestmate odor (120 to 160 ms); ii) ants' aggressiveness towards non-nestmates can be specifically reduced by exposure to non-nestmate odor only, showing that social interactions are not required to alter responses towards non-nestmates; iii) decision-making by ants does not require information transfer between brain hemispheres, but relies on side-specific decision rules. Conclusions/Significance Our results strongly suggest that first-order olfactory processing centers (up to the antennal lobes) are likely to play a key role in ant nestmate recognition. We hypothesize that the coarse level of discrimination achieved in the antennal lobes early in odor processing provides enough information to determine appropriate behavioral responses towards non-nestmates. This asks for a reappraisal of the mechanisms underlying social recognition in insects. PMID:20808782

14 CFR 1203.200 - Background and discussion.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 1203.200 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY PROGRAM NASA Information Security Program § 1203.200 Background and discussion. (a) In establishing a... public inspection of that information that is classified to protect the national security. (b) In...

14 CFR 1203.200 - Background and discussion.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 1203.200 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY PROGRAM NASA Information Security Program § 1203.200 Background and discussion. (a) In establishing a... public inspection of that information that is classified to protect the national security. (b) In...

Solid waste information and tracking system client-server conversion project management plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

May, D.L.

1998-04-15

This Project Management Plan is the lead planning document governing the proposed conversion of the Solid Waste Information and Tracking System (SWITS) to a client-server architecture. This plan presents the content specified by American National Standards Institute (ANSI)/Institute of Electrical and Electronics Engineers (IEEE) standards for software development, with additional information categories deemed to be necessary to describe the conversion fully. This plan is a living document that will be reviewed on a periodic basis and revised when necessary to reflect changes in baseline design concepts and schedules. This PMP describes the background, planning and management of the SWITS conversion.more » It does not constitute a statement of product requirements. Requirements and specification documentation needed for the SWITS conversion will be released as supporting documents.« less

Matching food security analysis to context: the experience of the Somalia food security assessment unit.

PubMed

Hemrich, Günter

2005-06-01

This case study reviews the experience of the Somalia Food Security Assessment Unit (FSAU) of operating a food security information system in the context of a complex emergency. In particular, it explores the linkages between selected features of the protracted crisis environment in Somalia and conceptual and operational aspects of food security information work. The paper specifically examines the implications of context characteristics for the establishment and operations of the FSAU field monitoring component and for the interface with information users and their diverse information needs. It also analyses the scope for linking food security and nutrition analysis and looks at the role of conflict and gender analysis in food security assessment work. Background data on the food security situation in Somalia and an overview of some key features of the FSAU set the scene for the case study. The paper is targeted at those involved in designing, operating and funding food security information activities.

Practical Communication Guidance to Improve Phase I Informed Consent Conversations and Decision-Making in Pediatric Oncology

PubMed Central

Johnson, Liza-Marie; Leek, Angela C.; Drotar, Dennis; Noll, Robert B.; Rheingold, Susan R.; Kodish, Eric D.; Baker, Justin N.

2015-01-01

Background It can be difficult to explain pediatric Phase I oncology trials to families of children with refractory cancer. Parents may misunderstand the information presented to them, and physicians may assume that certain topics are covered in the informed consent document and need not be discussed. Communication models can help to ensure effective discussions. Methods Suggestions for improving the informed consent process were first solicited from Phase I study clinicians via questionnaire. Eight parents who had enrolled their child on a Phase I pediatric oncology trial were recruited for an advisory group designed to assess the clinicians’ suggestions and make additional recommendations for improving informed consent for pediatric Phase I trials. Results A Phase I Communication Model was designed to incorporate the suggestions of clinicians and families. It focuses on education of parents/families about Phase I trials at specific time points during a child’s illness, but specifically at the point of relapse. We also present an informative Phase I fact sheet that can be distributed to families. Conclusions Families who will be offered information about a Phase I clinical trial can first receive a standardized fact sheet explaining the general purpose of these early-phase clinical trials. Parental understanding may be further enhanced when oncologists address key themes, beginning at diagnosis and continuing through important decision points during the child’s illness. This model should be prospectively evaluated. PMID:25873253

The Contribution of the Vaccine Adverse Event Text Mining System to the Classification of Possible Guillain-Barré Syndrome Reports

PubMed Central

Botsis, T.; Woo, E. J.; Ball, R.

2013-01-01

Background We previously demonstrated that a general purpose text mining system, the Vaccine adverse event Text Mining (VaeTM) system, could be used to automatically classify reports of an-aphylaxis for post-marketing safety surveillance of vaccines. Objective To evaluate the ability of VaeTM to classify reports to the Vaccine Adverse Event Reporting System (VAERS) of possible Guillain-Barré Syndrome (GBS). Methods We used VaeTM to extract the key diagnostic features from the text of reports in VAERS. Then, we applied the Brighton Collaboration (BC) case definition for GBS, and an information retrieval strategy (i.e. the vector space model) to quantify the specific information that is included in the key features extracted by VaeTM and compared it with the encoded information that is already stored in VAERS as Medical Dictionary for Regulatory Activities (MedDRA) Preferred Terms (PTs). We also evaluated the contribution of the primary (diagnosis and cause of death) and secondary (second level diagnosis and symptoms) diagnostic VaeTM-based features to the total VaeTM-based information. Results MedDRA captured more information and better supported the classification of reports for GBS than VaeTM (AUC: 0.904 vs. 0.777); the lower performance of VaeTM is likely due to the lack of extraction by VaeTM of specific laboratory results that are included in the BC criteria for GBS. On the other hand, the VaeTM-based classification exhibited greater specificity than the MedDRA-based approach (94.96% vs. 87.65%). Most of the VaeTM-based information was contained in the secondary diagnostic features. Conclusion For GBS, clinical signs and symptoms alone are not sufficient to match MedDRA coding for purposes of case classification, but are preferred if specificity is the priority. PMID:23650490

Spectral and temporal changes to speech produced in the presence of energetic and informational maskers.

PubMed

Cooke, Martin; Lu, Youyi

2010-10-01

Talkers change the way they speak in noisy conditions. For energetic maskers, speech production changes are relatively well-understood, but less is known about how informational maskers such as competing speech affect speech production. The current study examines the effect of energetic and informational maskers on speech production by talkers speaking alone or in pairs. Talkers produced speech in quiet and in backgrounds of speech-shaped noise, speech-modulated noise, and competing speech. Relative to quiet, speech output level and fundamental frequency increased and spectral tilt flattened in proportion to the energetic masking capacity of the background. In response to modulated backgrounds, talkers were able to reduce substantially the degree of temporal overlap with the noise, with greater reduction for the competing speech background. Reduction in foreground-background overlap can be expected to lead to a release from both energetic and informational masking for listeners. Passive changes in speech rate, mean pause length or pause distribution cannot explain the overlap reduction, which appears instead to result from a purposeful process of listening while speaking. Talkers appear to monitor the background and exploit upcoming pauses, a strategy which is particularly effective for backgrounds containing intelligible speech.

Introduction to the Centers for Disease Control and Prevention and Healthcare Infection Control Practices Advisory Committee Guideline for Prevention of Surgical Site Infection: Prosthetic Joint Arthroplasty Section.

PubMed

Segreti, John; Parvizi, Javad; Berbari, Elie; Ricks, Philip; Berríos-Torres, Sandra I

Peri-prosthetic joint infection (PJI) is a severe complication of total joint arthroplasty that appears to be increasing as more of these procedures are performed. Numerous risk factors for incisional (superficial and deep) and organ/space (e.g., PJI) surgical site infections (SSIs) have been identified. A better understanding and reversal of modifiable risk factors may lead to a reduction in the incidence of incisional SSI and PJI. The Centers for Disease Control and Prevention (CDC) and the Healthcare Infection Control Practices Advisory Committee (HICPAC) recently updated the national Guideline for Prevention of Surgical Site Infection. The updated guideline applies evidence-based methodology, presents recommendations for potential strategies to reduce the risk of SSI, and includes an arthroplasty-specific section. This article serves to introduce the guideline development process and to complement the Prosthetic Joint Arthroplasty section with background information on PJI-specific economic burden, epidemiology, pathogenesis and microbiology, and risk factor information.

Integrated action of pheromone signals in promoting courtship behavior in male mice

PubMed Central

Haga-Yamanaka, Sachiko; Ma, Limei; He, Jie; Qiu, Qiang; Lavis, Luke D; Looger, Loren L; Yu, C Ron

2014-01-01

The mammalian vomeronasal organ encodes pheromone information about gender, reproductive status, genetic background and individual differences. It remains unknown how pheromone information interacts to trigger innate behaviors. In this study, we identify vomeronasal receptors responsible for detecting female pheromones. A sub-group of V1re clade members recognizes gender-identifying cues in female urine. Multiple members of the V1rj clade are cognate receptors for urinary estrus signals, as well as for sulfated estrogen (SE) compounds. In both cases, the same cue activates multiple homologous receptors, suggesting redundancy in encoding female pheromone cues. Neither gender-specific cues nor SEs alone are sufficient to promote courtship behavior in male mice, whereas robust courtship behavior can be induced when the two cues are applied together. Thus, integrated action of different female cues is required in pheromone-triggered mating behavior. These results suggest a gating mechanism in the vomeronasal circuit in promoting specific innate behavior. DOI: http://dx.doi.org/10.7554/eLife.03025.001 PMID:25073926

Demographic and Motivation Differences Among Online Sex Offenders by Type of Offense: An Exploration of Routine Activities Theories.

PubMed

Navarro, Jordana N; Jasinski, Jana L

2015-01-01

This article presents an analysis of the relationship between online sexual offenders' demographic background and characteristics indicative of motivation and offense type. Specifically, we investigate whether these characteristics can distinguish different online sexual offender groups from one another as well as inform routine activity theorists on what potentially motivates perpetrators. Using multinomial logistic regression, this study found that online sexual offenders' demographic backgrounds and characteristics indicative of motivation do vary by offense types. Two important implications of this study are that the term "online sexual offender" encompasses different types of offenders, including some who do not align with mainstream media's characterization of "predators," and that the potential offender within routine activity theory can be the focus of empirical investigation rather than taken as a given in research.

[Mental health in adolescents in Germany: A comparison with regard to migration background and country of origin].

PubMed

Brettschneider, Anna-Kristin; Hölling, H; Schlack, R; Ellert, U

2015-04-01

Many children and adolescents in Germany grow up in families with a migration background. Different cultural, religious, and linguistic backgrounds have an influence on their behavior in various ways. Health status can be affected both negatively and positively by a migration background. The aim of this study was to analyze associations between migration background and self-reported psychological problems. In addition, it was tested whether country of origin had a differential effect on the associations found. Because of its migration-specific approach, the baseline survey (2003-2006) of the nationwide German Health Interview and Examination Survey for Children and Adolescents (KiGGS) offers a solid basis for migrant-specific analyses. Self-reported mental health problems were assessed using the Strengths and Difficulties Questionnaire (SDQ), which was completed by 6,719 adolescents aged 11-17 years. Adolescents with a two-sided migration background (i.e., both parents) reported higher SDQ total difficulties scores compared with adolescents without a migration background (16.9 vs 11.5%) or those with a one-sided migration background (16.9 vs 11.3%). Adolescents with a Turkish background had higher odds (boys: OR 2.0; 95%CI 1.3-3.2; girls: OR 2.0; 95%CI 1.2-3.4) of reporting mental health problems than adolescents without a migration background. Also, girls with a migration background from Western Europe, the USA or Canada had higher odds (OR 2.2; 95%CI 1.3-3.6). In some cases, adjusting for socioeconomic status led to insignificant associations with regard to the country of origin. The findings underline the importance of migrant-specific and culture-sensitive prevention, which also takes the environment and culture-specific characteristics into account.

Natural Mosquito-Pathogen Hybrid IgG4 Antibodies in Vector-Borne Diseases: A Hypothesis.

PubMed

Londono-Renteria, Berlin; Cardenas, Jenny C; Troupin, Andrea; Colpitts, Tonya M

2016-01-01

Chronic exposure to antigens may favor the production of IgG4 antibodies over other antibody types. Recent studies have shown that up to a 30% of normal human IgG4 is bi-specific and is able to recognize two antigens of different nature. A requirement for this specificity is the presence of both eliciting antigens in the same time and at the same place where the immune response is induced. During transmission of most vector-borne diseases, the pathogen is delivered to the vertebrate host along with the arthropod saliva during blood feeding and previous studies have shown the existence of IgG4 antibodies against mosquito salivary allergens. However, there is very little ongoing research or information available regarding IgG4 bi-specificity with regard to infectious disease, particularly during immune responses to vector-borne diseases, such as malaria, filariasis, or dengue virus infection. Here, we provide background information and present our hypothesis that IgG4 may not only be a useful tool to measure exposure to infected mosquito bites, but that these bi-specific antibodies may also play an important role in modulation of the immune response against malaria and other vector-borne diseases in endemic settings.

The effect of sequential information on consumers' willingness to pay for credence food attributes.

PubMed

Botelho, A; Dinis, I; Lourenço-Gomes, L; Moreira, J; Costa Pinto, L; Simões, O

2017-11-01

The use of experimental methods to determine consumers' willingness to pay for "quality" food has been gaining importance in scientific research. In most of the empirical literature on this issue the experimental design starts with blind tasting, after which information is introduced. It is assumed that this approach allows consumers to elicit the real value that they attach to each of the features added through specific information. In this paper, the starting hypothesis is that this technique overestimates the weight of the features introduced by information in consumers' willingness to pay when compared to a real market situation, in which consumers are confronted with all the information at once. The data obtained through contingent valuation in an in-store setting was used to estimate a hedonic model aiming at assessing consumers' willingness to pay (WTP) for the feature "geographical origin of the variety" of pears and apples in different information scenarios: i) blind tasting followed by extrinsic information and ii) full information provided at once. The results show that, in fact, features are more valued when gradually added to background information than when consumers receive all the information from the beginning. Copyright © 2017 Elsevier Ltd. All rights reserved.

How Patients With Schizophrenia Use the Internet: Qualitative Study

PubMed Central

Sibitz, Ingrid; Unger, Annemarie; Amering, Michaela

2010-01-01

Background The Internet is an important source of health information for people with psychiatric conditions. Little is known about the way patients with schizophrenia use the Internet when it comes to issues related to their illness. Data on their specific needs, difficulties, and the consequences related to Internet use are lacking. Objective Our objective was to investigate the nature and subjective consequences of health-related Internet use among patients with schizophrenia. Methods In all, 26 individual semistructured interviews were conducted and analyzed qualitatively in groups of 4 until theoretical saturation was achieved. Results Study results suggest that the Internet is an influential source of illness-related information for patients with schizophrenia. Many aspects of their behavior around the Internet resemble those of individuals not afflicted by mental illness. Importantly, problems specific to patients with schizophrenia were stimulus overflow, an inability to deal with the abundance of information, difficulties with concentration, lack of energy, paranoid ideas, symptom provocation, and the need to distance themselves from illness-related topics as part of the recovery process. Internet information was subjectively perceived as having the potential to significantly change patients’ attitudes toward medication and their relationships with doctors. Conclusions These findings provide insight into how individuals with schizophrenia handle illness-related Internet information. The data could contribute to the continuous development of Internet-based interventions and offer novel approaches to optimizing traditional treatment options. PMID:21169176

How Animals Understand the Meaning of Indefinite Information from Environments?

NASA Astrophysics Data System (ADS)

Shimizu, H.; Yamaguchi, Y.

Animals, including human beings, have ability to understand the meaning of indefinite information from environments. Thanks to this ability the animals have flexibility in their behaviors for the environmental changes. Staring from a hypothesis that understanding of the input (Shannonian) information is based on the self-organization of a neuronal representation, that is, a spatio-temporal pattern constituted of coherent activities of neurons encoding a ``figure'', being separated from the ``background'' encoded by incoherent activities, the conditions necessary for the understanding of indefinite information were discussed. The crucial conditions revealed are that the neuronal system is incomplete or indefinite in a sense that its rules for the self-organization of the neuronal activities are completed only after the input of the environmental information and that it has an additional system named "self-specific to relevantly self-organize dynamical ``constraints'' or ``boundary conditions'' for the self-organization of the representation. For the simultaneous self-organizations of the relevant constraints and the representation, a global circulation of activities must be self-organized between these two kinds of neuronal systems. Moreover, for the performance of these functions, a specific kind of synergetic elements, ``holon elements'', are also necessary. By means of a neuronal model, the visual perception of indefinite input signals is demonstrated. The results obtained are consistent with those recently observed in the visual cortex of cats.

Analysis of the site-specific carbon isotope composition of propane by gas source isotope ratio mass spectrometer

NASA Astrophysics Data System (ADS)

Piasecki, Alison; Sessions, Alex; Lawson, Michael; Ferreira, A. A.; Neto, E. V. Santos; Eiler, John M.

2016-09-01

Site-specific isotope ratio measurements potentially provide valuable information about the formation and degradation of complex molecules-information that is lost in conventional bulk isotopic measurements. Here we discuss the background and possible applications of such measurements, and present a technique for studying the site-specific carbon isotope composition of propane at natural abundance based on mass spectrometric analysis of the intact propane molecule and its fragment ions. We demonstrate the feasibility of this approach through measurements of mixtures of natural propane and propane synthesized with site-specific 13C enrichment, and we document the limits of precision of our technique. We show that mass balance calculations of the bulk δ13C of propane based on our site-specific measurements is generally consistent with independent constraints on bulk δ13C. We further demonstrate the accuracy of the technique, and illustrate one of its simpler applications by documenting the site-specific carbon isotope signature associated with gas phase diffusion of propane, confirming that our measurements conform to the predictions of the kinetic theory of gases. This method can be applied to propane samples of moderate size (tens of micromoles) isolated from natural gases. Thus, it provides a means of studying the site-specific stable isotope systematics of propane at natural isotope abundances on sample sizes that are readily recovered from many natural environments. This method may also serve as a model for future techniques that apply high-resolution mass spectrometry to study the site-specific isotopic distributions of larger organic molecules, with potential applications to biosynthesis, forensics and other geochemical subjects.

Field Manual of Wildlife Diseases

USGS Publications Warehouse

Franson, J. Christian; Friend, Milton; Gibbs, Samantha E.J.; Wild, Margaret A.

2015-01-01

We begin this new manual with introductory contextual and historical background about the convergence of wildlife disease with wildlife management as a wildlife conservation concern (section A, chap. 1). The remainder of the publication is focused on pragmatic information and considerations for addressing various aspects of wildlife disease. Section B focuses on concepts associated with disease surveillance and response to outbreaks, and section C deals with specific techniques for disease surveillance and investigation. Section D, “Diseases of Wild Birds,” and others that follow will address diseases of concern in various species groups. Electronic links facilitate timely access to a wide variety of supplemental information and processes relevant to content in this new version of the “Field Manual of Wildlife Diseases.”

About nutria and their control

USGS Publications Warehouse

Evans, James

1970-01-01

This report presents much of the information we gathered during this four-year period about nutria and how to control them. Because it is meant primarily for the general public, it omits the specific references to the scientific literature that pepper most technical reports, but it does present background information on the history, biology, and behavior of nutria, particularly those in the Gulf Coast Region. The control methods presented, when used as directed, are safe and effective and provide solutions for most situations, including those where people want to alleviate nutria damage without killing the nutria. Though we were pleased with these results, research still continues, directed toward discovering new and better methods of control that will solve any future problem with nutria.

A review and evaluation of numerical tools for fractional calculus and fractional order controls

NASA Astrophysics Data System (ADS)

Li, Zhuo; Liu, Lu; Dehghan, Sina; Chen, YangQuan; Xue, Dingyü

2017-06-01

In recent years, as fractional calculus becomes more and more broadly used in research across different academic disciplines, there are increasing demands for the numerical tools for the computation of fractional integration/differentiation, and the simulation of fractional order systems. Time to time, being asked about which tool is suitable for a specific application, the authors decide to carry out this survey to present recapitulative information of the available tools in the literature, in hope of benefiting researchers with different academic backgrounds. With this motivation, the present article collects the scattered tools into a dashboard view, briefly introduces their usage and algorithms, evaluates the accuracy, compares the performance, and provides informative comments for selection.

Moving toward mainstream: perspectives on enhancing therapy with men.

PubMed

Wade, Jay C; Good, Glenn E

2010-09-01

Psychotherapists began sharing their clinical experiences with men's gender-related psychological issues and the challenges of addressing them in therapy during the late 1970s and early 1980s (e.g., O'Neil, 1981; Scher, 1979; Skovholt, 1978). However, it has taken several decades for these messages and the accompanying research to yield advances that are being adopted into more mainstream psychotherapeutic practices. Over the recent three decades, the theory, research, and clinical wisdom about psychotherapy with men can be viewed as falling into several main clusters. Specifically, there is literature and research providing: - General information on masculine socialization and the psychology of men. - Information about specific issues that men and male clients bring to therapy. - Information about the expectations and experiences of specific groups of men (e.g., men of differing racial/ethnic backgrounds, geographical regions, age cohorts, spiritual/religious beliefs, differing physical ability statuses). - Suggestions for addressing men's reluctance to seek psychotherapy and the challenges associated with forming therapeutic working alliances with men when they do come to therapy. - Suggestions regarding adjustments to psychotherapeutic processes for conducting effective psychotherapy with men. - Development and assessment of instruments to assess endorsement of various male norms and of aspects of men's gender role conflict and stress. Reviewing the earliest writings, some of these pioneering therapists' initial clinical observations remain highly relevant today. (PsycINFO Database Record (c) 2010 APA, all rights reserved).

Effectiveness of Journal Ranking Schemes as a Tool for Locating Information

PubMed Central

Stringer, Michael J.; Sales-Pardo, Marta; Nunes Amaral, Luís A.

2008-01-01

Background The rise of electronic publishing [1], preprint archives, blogs, and wikis is raising concerns among publishers, editors, and scientists about the present day relevance of academic journals and traditional peer review [2]. These concerns are especially fuelled by the ability of search engines to automatically identify and sort information [1]. It appears that academic journals can only remain relevant if acceptance of research for publication within a journal allows readers to infer immediate, reliable information on the value of that research. Methodology/Principal Findings Here, we systematically evaluate the effectiveness of journals, through the work of editors and reviewers, at evaluating unpublished research. We find that the distribution of the number of citations to a paper published in a given journal in a specific year converges to a steady state after a journal-specific transient time, and demonstrate that in the steady state the logarithm of the number of citations has a journal-specific typical value. We then develop a model for the asymptotic number of citations accrued by papers published in a journal that closely matches the data. Conclusions/Significance Our model enables us to quantify both the typical impact and the range of impacts of papers published in a journal. Finally, we propose a journal-ranking scheme that maximizes the efficiency of locating high impact research. PMID:18301760

Contact, Travel, and Transmission: The Impact of Winter Holidays on Influenza Dynamics in the United States

PubMed Central

Ewing, Anne; Lee, Elizabeth C.; Viboud, Cécile

2017-01-01

Abstract Background. The seasonality of influenza is thought to vary according to environmental factors and human behavior. During winter holidays, potential disease-causing contact and travel deviate from typical patterns. We aim to understand these changes on age-specific and spatial influenza transmission. Methods. We characterized the changes to transmission and epidemic trajectories among children and adults in a spatial context before, during, and after the winter holidays among aggregated physician medical claims in the United States from 2001 to 2009 and among synthetic data simulated from a deterministic, age-specific spatial metapopulation model. Results. Winter holidays reduced influenza transmission and delayed the trajectory of influenza season epidemics. The holiday period was marked by a shift in the relative risk of disease from children toward adults. Model results indicated that holidays delayed epidemic peaks and synchronized incidence across locations, and that contact reductions from school closures, rather than age-specific mixing and travel, produced these observed holiday influenza dynamics. Conclusions. Winter holidays delay seasonal influenza epidemic peaks and shift disease risk toward adults because of changes in contact patterns. These findings may inform targeted influenza information and vaccination campaigns during holiday periods. PMID:28031259

THE ORIGIN OF ASTEROID 162173 (1999 JU{sub 3})

DOE Office of Scientific and Technical Information (OSTI.GOV)

Campins, Humberto; De Leon, Julia; Morbidelli, Alessandro

Near-Earth asteroid (162173) 1999 JU{sub 3} (henceforth JU{sub 3}) is a potentially hazardous asteroid and the target of the Japanese Aerospace Exploration Agency's Hayabusa-2 sample return mission. JU{sub 3} is also a backup target for two other sample return missions: NASA's OSIRIS-REx and the European Space Agency's Marco Polo-R. We use dynamical information to identify an inner-belt, low-inclination origin through the {nu}{sub 6} resonance, more specifically, the region with 2.15 AU < a < 2.5 AU and i < 8 Degree-Sign . The geometric albedo of JU{sub 3} is 0.07 {+-} 0.01, and this inner-belt region contains four well-defined low-albedomore » asteroid families (Clarissa, Erigone, Polana, and Sulamitis), plus a recently identified background population of low-albedo asteroids outside these families. Only two of these five groups, the background and the Polana family, deliver JU{sub 3}-sized asteroids to the {nu}{sub 6} resonance, and the background delivers significantly more JU{sub 3}-sized asteroids. The available spectral evidence is also diagnostic; the visible and near-infrared spectra of JU{sub 3} indicate it is a C-type asteroid, which is compatible with members of the background, but not with the Polana family because it contains primarily B-type asteroids. Hence, this background population of low-albedo asteroids is the most likely source of JU{sub 3}.« less

Paediatric patient navigation models of care in Canada: An environmental scan.

PubMed

Luke, Alison; Doucet, Shelley; Azar, Rima

2018-05-01

(1) To provide other organizations with useful information when implementing paediatric navigation programs and (2) to inform the implementation of a navigation care centre in New Brunswick for children with complex health conditions. This environmental scan consisted of a literature review of published and grey literature for paediatric patient navigation programs across Canada. Additional programs were found following discussions with program coordinators and navigators. Interviews were conducted with key staff from each program and included questions related to patient condition; target population and location; method delivery; navigator background; and navigator roles. Data analysis included analysis of interviews and identification of common themes across the different programs. We interviewed staff from 19 paediatric navigation programs across Canada. Programs varied across a number of different themes, including: condition and disease type, program location (e.g., hospital or clinic), navigator background (e.g., registered nurse or peer/lay navigator) and method of delivery (e.g., phone or face-to-face). Overall, navigator roles are similar across all programs, including advocacy, education, support and assistance in accessing resources from both within and outside the health care system. This scan offers a road map of Canadian paediatric navigation programs. Knowledge learned from this scan will inform stakeholders who are either involved in the delivery of paediatric patient navigation programs or planning to implement such a program. Specifically, our scan informed the development of a navigation centre for children with complex health conditions in New Brunswick.

Gaps in Survey Data on Cancer in American Indian and Alaska Native Populations: Examination of US Population Surveys, 1960–2010

PubMed Central

Duran, Tinka; Stimpson, Jim P.; Smith, Corey

2013-01-01

Introduction Population-based data are essential for quantifying the problems and measuring the progress made by comprehensive cancer control programs. However, cancer information specific to the American Indian/Alaska Native (AI/AN) population is not readily available. We identified major population-based surveys conducted in the United States that contain questions related to cancer, documented the AI/AN sample size in these surveys, and identified gaps in the types of cancer-related information these surveys collect. Methods We conducted an Internet query of US Department of Health and Human Services agency websites and a Medline search to identify population-based surveys conducted in the United States from 1960 through 2010 that contained information about cancer. We used a data extraction form to collect information about the purpose, sample size, data collection methods, and type of information covered in the surveys. Results Seventeen survey sources met the inclusion criteria. Information on access to and use of cancer treatment, follow-up care, and barriers to receiving timely and quality care was not consistently collected. Estimates specific to the AI/AN population were often lacking because of inadequate AI/AN sample size. For example, 9 national surveys reviewed reported an AI/AN sample size smaller than 500, and 10 had an AI/AN sample percentage less than 1.5%. Conclusion Continued efforts are needed to increase the overall number of AI/AN participants in these surveys, improve the quality of information on racial/ethnic background, and collect more information on treatment and survivorship. PMID:23517582

Australian consumer awareness of health benefits associated with vegetable consumption.

PubMed

Rekhy, Reetica; Khan, Aila; Eason, Jocelyn; Mactavish-West, Hazel; Lister, Carolyn; Mcconchie, Robyn

2017-04-01

The present study investigated the perceived health benefits of specific vegetable consumption to guide the use of nutrition and health claims on vegetable marketing collateral. Free elicitation and consumer ranking data were collected through an online survey of 1000 adults from across Australia and analysed for the perceived importance of vegetables in the daily diet, number of serves consumed per day, knowledge about health-related benefits of specific vegetables and perceived health benefits of vegetable consumption. The importance of vegetables in the diet and daily vegetable consumption was higher in people from an English-speaking background, females, people aged 45 years and over and people living in non-metropolitan areas. Digestion was selected as the major health benefit from consumption of specific vegetables. However, understanding of the health benefits of specific vegetable consumption was relatively low among consumers. Half of the respondents were not sure of the health benefits associated with specific vegetables, except for carrots and spinach. Some respondents volunteered nutrient content or other information. There was no clear indication that consumers understand the specific health benefits conferred by consumption of vegetables. Nutrient and health benefit labelling therefore has the capacity to enhance knowledge of vegetable consumers. It is recommended that health benefit labelling be tailored to promote greater consumption of vegetables in those demographic groups where vegetable consumption was lower. The present study assists the Australian vegetable industry in helping consumers make more informed consumption choices. © 2016 Dietitians Association of Australia.

National Athletic Trainers' Association Position Statement: Preventing Sudden Death in Sports

PubMed Central

Casa, Douglas J.; Guskiewicz, Kevin M.; Anderson, Scott A.; Courson, Ronald W.; Heck, Jonathan F.; Jimenez, Carolyn C.; McDermott, Brendon P.; Miller, Michael G.; Stearns, Rebecca L.; Swartz, Erik E.; Walsh, Katie M.

2012-01-01

Objective: To present recommendations for the prevention and screening, recognition, and treatment of the most common conditions resulting in sudden death in organized sports. Background: Cardiac conditions, head injuries, neck injuries, exertional heat stroke, exertional sickling, asthma, and other factors (eg, lightning, diabetes) are the most common causes of death in athletes. Recommendations: These guidelines are intended to provide relevant information on preventing sudden death in sports and to give specific recommendations for certified athletic trainers and others participating in athletic health care. PMID:22488236

Expert systems applied to fault isolation and energy storage management, phase 2

NASA Technical Reports Server (NTRS)

1987-01-01

A user's guide for the Fault Isolation and Energy Storage (FIES) II system is provided. Included are a brief discussion of the background and scope of this project, a discussion of basic and advanced operating installation and problem determination procedures for the FIES II system and information on hardware and software design and implementation. A number of appendices are provided including a detailed specification for the microprocessor software, a detailed description of the expert system rule base and a description and listings of the LISP interface software.

The Chronotron: A Neuron That Learns to Fire Temporally Precise Spike Patterns

PubMed Central

Florian, Răzvan V.

2012-01-01

In many cases, neurons process information carried by the precise timings of spikes. Here we show how neurons can learn to generate specific temporally precise output spikes in response to input patterns of spikes having precise timings, thus processing and memorizing information that is entirely temporally coded, both as input and as output. We introduce two new supervised learning rules for spiking neurons with temporal coding of information (chronotrons), one that provides high memory capacity (E-learning), and one that has a higher biological plausibility (I-learning). With I-learning, the neuron learns to fire the target spike trains through synaptic changes that are proportional to the synaptic currents at the timings of real and target output spikes. We study these learning rules in computer simulations where we train integrate-and-fire neurons. Both learning rules allow neurons to fire at the desired timings, with sub-millisecond precision. We show how chronotrons can learn to classify their inputs, by firing identical, temporally precise spike trains for different inputs belonging to the same class. When the input is noisy, the classification also leads to noise reduction. We compute lower bounds for the memory capacity of chronotrons and explore the influence of various parameters on chronotrons' performance. The chronotrons can model neurons that encode information in the time of the first spike relative to the onset of salient stimuli or neurons in oscillatory networks that encode information in the phases of spikes relative to the background oscillation. Our results show that firing one spike per cycle optimizes memory capacity in neurons encoding information in the phase of firing relative to a background rhythm. PMID:22879876

Black Officer Accession and Retention

DTIC Science & Technology

1980-05-15

of Historically Black educational institutions. FACT. Provided for information at inclosure 1 is correspondence frcm HQ DA outlining the...CHAPTER I. INTRODUCTION ............... ....................... 1 Background Information ...INTRODUCTION BACKGROUND INFORMATION A gro’np of black students from the US Army War College Class of 󈨓, reached the conclusion that black officers were

Spectrometry: Report of panel

NASA Technical Reports Server (NTRS)

Farmer, C. Barney; Murcray, David G.; Abreu, Vincent; Gille, John C.; Hanel, Rudolph A.; Hoell, James M., Jr.; Jamieson, John A.; Zwick, Harold

1987-01-01

Spectroscopic measurements are required to define the spectral background and provide the detailed spectral information that is essential for the design of species-specific systems and the analysis of data obtained from them. This function of spectroscopic measurements is expected to be an important part of any tropospheric remote-sensing program, and both emission and absorption spectroscopy are relevant in this context. The data from such observations are of value to tropospheric science in their own right, during the initial phases while species-specific techniques and instruments are under development. In addition, there are a number of unresolved problems in tropospheric radiative transfer and spectroscopy which presently limit the accuracy and reliability of all remote sensing methods. Only through a supporting program of spectroscopic measurements can progress be made in improving the understanding of these aspects of radiative transfer and ultimately reaching the desired confidence in the accuracy to species-specific monitoring techniques.

Significance of Cuscutain, a cysteine protease from Cuscuta reflexa, in host-parasite interactions

PubMed Central

2010-01-01

Background Plant infestation with parasitic weeds like Cuscuta reflexa induces morphological as well as biochemical changes in the host and the parasite. These modifications could be caused by a change in protein or gene activity. Using a comparative macroarray approach Cuscuta genes specifically upregulated at the host attachment site were identified. Results One of the infestation specific Cuscuta genes encodes a cysteine protease. The protein and its intrinsic inhibitory peptide were heterologously expressed, purified and biochemically characterized. The haustoria specific enzyme was named cuscutain in accordance with similar proteins from other plants, e.g. papaya. The role of cuscutain and its inhibitor during the host parasite interaction was studied by external application of an inhibitor suspension, which induced a significant reduction of successful infection events. Conclusions The study provides new information about molecular events during the parasitic plant - host interaction. Inhibition of cuscutain cysteine proteinase could provide means for antagonizing parasitic plants. PMID:20964874

Learning to Link Visual Contours

PubMed Central

Li, Wu; Piëch, Valentin; Gilbert, Charles D.

2008-01-01

SUMMARY In complex visual scenes, linking related contour elements is important for object recognition. This process, thought to be stimulus driven and hard wired, has substrates in primary visual cortex (V1). Here, however, we find contour integration in V1 to depend strongly on perceptual learning and top-down influences that are specific to contour detection. In naive monkeys the information about contours embedded in complex backgrounds is absent in V1 neuronal responses, and is independent of the locus of spatial attention. Training animals to find embedded contours induces strong contour-related responses specific to the trained retinotopic region. These responses are most robust when animals perform the contour detection task, but disappear under anesthesia. Our findings suggest that top-down influences dynamically adapt neural circuits according to specific perceptual tasks. This may serve as a general neuronal mechanism of perceptual learning, and reflect top-down mediated changes in cortical states. PMID:18255036

Unmet Information Needs and Quality of Life in Young Breast Cancer Survivors in Japan

PubMed Central

Miyashita, Mika; Ohno, Shinji; Kataoka, Akemi; Tokunaga, Eriko; Masuda, Norikazu; Shien, Tadahiko; Kawabata, Kimiko; Takahashi, Miyako

2015-01-01

Background: Young breast cancer survivors have specific needs related to age. Clarifying the relationships between unmet information needs and quality of life (QOL) in young breast cancer survivors can contribute to constructing a support system to enhance QOL in patients. Objective: This study aimed to identify the unmet information needs and examine the relationships between unmet information needs and QOL in young breast cancer survivors in Japan. Methods: Participants completed an information needs questionnaire containing 26 items, the World Health Organization Quality of Life Instrument–Short Form (WHOQOL-BREF), and a demographic and medical information questionnaire. Results: Fifty participants (30.7%) were unsatisfied with “overall communication with medical professionals.” The mean scores on all subscales of the WHOQOL-BREF of the participants who were satisfied with “overall communication with medical professionals” were significantly higher than those of the unsatisfied group. “follow-up tests,” “treatment for recurrence of breast cancer,” “strategies about communication with medical staff,” and “nutrition” were significantly related with all subscales in the WHOQOL-BREF. “Secondary menopause caused by hormonal therapy” was significantly related with physical and psychological health. Conclusions: Japanese young breast cancer survivors have unmet information needs, including age-specific issues. These unmet information needs are related to QOL. In particular, “overall communication with medical professionals,” which is the most unmet information need, is related to QOL. Implications for Practice: Oncology nurses should teach patients communication skills, provide adequate information, and provide education and emotional support to medical professionals to improve QOL in young breast cancer survivors. PMID:25254410

Collaborative learning in teaching information management

NASA Astrophysics Data System (ADS)

Natho, N.; Knipping, L.; Pfeiffer, O.; Schröder, C.; Zorn, E.; Jeschke, S.

2010-08-01

In this paper, we present the course called 'New Media in Education and Research', which employs a blended learning approach. This course is a part of a new bachelor's programme 'Natural Sciences in the Information Society' that is in place in TU Berlin. The main goal of this course is to provide the students with the appropriate information technology literacy that they will need during their studies and beyond. A more specific goal of the course is to train the students to collaborate in small groups. Tablet PCs with OneNote installed on it act as agents to communicate some of the technological aspects as well as soft skills in a blended learning scenario. We discuss the pedagogical and technological backgrounds of the course and we present the implementation of the course. We conclude with a review of our results and an outlook to future work.

[Trauma-Informed Peer Counselling in the Care of Refugees with Trauma-Related Disorders].

PubMed

Wöller, Wolfgang

2016-09-01

Providing adequate culture-sensitive care for a large number of refugees with trauma-related disorders constitutes a major challenge. In this context, peer support and trauma-informed peer counselling can be regarded as a valuable means to complement the psychosocial care systems. In recent years, peer support and peer education have been successfully implemented e. g. in health care education, in psychiatric care, and in the treatment of traumatized individuals. Only little research data is available for traumatized refugees. However, results are encouraging. A program is presented which integrates trauma-informed peer educators (TIP) with migration background in the care of traumatized refugees. Peers' responsibility includes emotional support and understanding the refugees' needs, sensitizing for trauma-related disorders, providing psychoeducation, and teaching trauma-specific stabilization techniques under supervision of professional psychotherapists. © Georg Thieme Verlag KG Stuttgart · New York.

Informal E-waste recycling in developing countries: review of metal(loid)s pollution, environmental impacts and transport pathways.

PubMed

Ackah, Michael

2017-11-01

Crude or primitive recycling practices are often adopted in material resource recovery from E-waste in developing nations. Significant human health and environmental impacts may occur because of such practices. Literature on metal(loid)s pollution during E-waste processing is fragmented. Here, I review the health and environmental impacts of E-waste recycling operations and transport pathways of metal(loid)s, dispersed during operations. This paper is organised into five sections. Section 1 relates to the background of global E-waste generation and legal/illegal trade, citing specific cases from Ghana and other developing nations. Section 2 provides a brief information on sources of metal(loid)s in E-waste. Section 3 describes characteristics of informal E-waste recycling operations in developing nations. Section 4 examines the health and environmental impacts in E-waste recycling while section 5 evaluates major transport pathways of metal(loid)s contaminants.

Optically detected X-ray absorption spectroscopy measurements as a means of monitoring corrosion layers on copper.

PubMed

Dowsett, Mark G; Adriaens, Annemie; Jones, Gareth K C; Poolton, Nigel; Fiddy, Steven; Nikitenko, Sergé

2008-11-15

XANES and EXAFS information is conventionally measured in transmission through the energy-dependent absorption of X-rays or by observing X-ray fluorescence, but secondary fluorescence processes, such as the emission of electrons and optical photons (e.g., 200-1000 nm), can also be used as a carrier of the XAS signatures, providing complementary information such as improved surface specificity. Where the near-visible photons have a shorter range in a material, the data will be more surface specific. Moreover, optical radiation may escape more readily than X-rays through liquid in an environmental cell. Here, we describe a first test of optically detected X-ray absorption spectroscopy (ODXAS) for monitoring electrochemical treatments on copper-based alloys, for example, heritage metals. Artificially made corrosion products deposited on a copper substrate were analyzed in air and in a 1% (w/v) sodium sesquicarbonate solution to simulate typical conservation methods for copper-based objects recovered from marine environments. The measurements were made on stations 7.1 and 9.2 MF (SRS Daresbury, UK) using the mobile luminescence end station (MoLES), supplemented by XAS measurements taken on DUBBLE (BM26 A) at the ESRF. The ODXAS spectra usually contain fine structure similar to that of XAS spectra measured in X-ray fluorescence. Importantly, for the compounds examined, the ODXAS is significantly more surface specific, and >98% characteristic of thin surface layers of 0.5-1.5-microm thickness in cases where X-ray measurements are dominated by the substrate. However, EXAFS and XANES from broadband optical measurements are superimposed on a high background due to other optical emission modes. This produces statistical fluctuations up to double what would be expected from normal counting statistics because the data retain the absolute statistical fluctuation in the original raw count, while losing up to 70% of their magnitude when background is removed. The problem may be solved in future through optical filtering to isolate the information-containing band, combined with the use of higher input X-ray fluxes available on third-generation light sources.

Neural Computation of Surface Border Ownership and Relative Surface Depth from Ambiguous Contrast Inputs.

PubMed

Dresp-Langley, Birgitta; Grossberg, Stephen

2016-01-01

The segregation of image parts into foreground and background is an important aspect of the neural computation of 3D scene perception. To achieve such segregation, the brain needs information about border ownership; that is, the belongingness of a contour to a specific surface represented in the image. This article presents psychophysical data derived from 3D percepts of figure and ground that were generated by presenting 2D images composed of spatially disjoint shapes that pointed inward or outward relative to the continuous boundaries that they induced along their collinear edges. The shapes in some images had the same contrast (black or white) with respect to the background gray. Other images included opposite contrasts along each induced continuous boundary. Psychophysical results demonstrate conditions under which figure-ground judgment probabilities in response to these ambiguous displays are determined by the orientation of contrasts only, not by their relative contrasts, despite the fact that many border ownership cells in cortical area V2 respond to a preferred relative contrast. Studies are also reviewed in which both polarity-specific and polarity-invariant properties obtain. The FACADE and 3D LAMINART models are used to explain these data.

Neural Computation of Surface Border Ownership and Relative Surface Depth from Ambiguous Contrast Inputs

PubMed Central

Dresp-Langley, Birgitta; Grossberg, Stephen

2016-01-01

The segregation of image parts into foreground and background is an important aspect of the neural computation of 3D scene perception. To achieve such segregation, the brain needs information about border ownership; that is, the belongingness of a contour to a specific surface represented in the image. This article presents psychophysical data derived from 3D percepts of figure and ground that were generated by presenting 2D images composed of spatially disjoint shapes that pointed inward or outward relative to the continuous boundaries that they induced along their collinear edges. The shapes in some images had the same contrast (black or white) with respect to the background gray. Other images included opposite contrasts along each induced continuous boundary. Psychophysical results demonstrate conditions under which figure-ground judgment probabilities in response to these ambiguous displays are determined by the orientation of contrasts only, not by their relative contrasts, despite the fact that many border ownership cells in cortical area V2 respond to a preferred relative contrast. Studies are also reviewed in which both polarity-specific and polarity-invariant properties obtain. The FACADE and 3D LAMINART models are used to explain these data. PMID:27516746

Firearm laws: a primer for psychiatrists.

PubMed

Price, Marilyn; Norris, Donna Marie

2010-01-01

Persons with mental illness or substance abuse have been perceived by the public to pose an increased risk of violence to themselves and others. As a result, federal and state laws have restricted the right of certain categories of persons with mental illness or substance abuse to possess, register, license, retain, or carry a firearm. Clinicians should be familiar with the specific firearm statutes of their own states, which describe the disqualifying mental health/substance abuse history and the role and responsibility of the psychiatrist in the process. State statutes vary widely in terms of the definitions of, and reporting requirements relating to, prohibited persons with mental illness or substance abuse. States also vary in the duration of the prohibition and in the timing of the appeals process. Some of the statutes have specific provisions for the removal of a firearm when a prohibited person is identified. States may maintain a mental health database that is used to determine firearm eligibility and may forward information to the National Instant Criminal Background Check System. The National Instant Criminal Background Check System Improvement Amendments Act of 2007 will likely increase the number of persons identified as belonging to the prohibited class.

Reconstruction of hyperspectral image using matting model for classification

NASA Astrophysics Data System (ADS)

Xie, Weiying; Li, Yunsong; Ge, Chiru

2016-05-01

Although hyperspectral images (HSIs) captured by satellites provide much information in spectral regions, some bands are redundant or have large amounts of noise, which are not suitable for image analysis. To address this problem, we introduce a method for reconstructing the HSI with noise reduction and contrast enhancement using a matting model for the first time. The matting model refers to each spectral band of an HSI that can be decomposed into three components, i.e., alpha channel, spectral foreground, and spectral background. First, one spectral band of an HSI with more refined information than most other bands is selected, and is referred to as an alpha channel of the HSI to estimate the hyperspectral foreground and hyperspectral background. Finally, a combination operation is applied to reconstruct the HSI. In addition, the support vector machine (SVM) classifier and three sparsity-based classifiers, i.e., orthogonal matching pursuit (OMP), simultaneous OMP, and OMP based on first-order neighborhood system weighted classifiers, are utilized on the reconstructed HSI and the original HSI to verify the effectiveness of the proposed method. Specifically, using the reconstructed HSI, the average accuracy of the SVM classifier can be improved by as much as 19%.

Alternatives to project-specific consent for access to personal information for health research: Insights from a public dialogue

PubMed Central

Willison, Donald J; Swinton, Marilyn; Schwartz, Lisa; Abelson, Julia; Charles, Cathy; Northrup, David; Cheng, Ji; Thabane, Lehana

2008-01-01

Background The role of consent for research use of health information is contentious. Most discussion has focused on when project-specific consent may be waived but, recently, a broader range of consent options has been entertained, including broad opt-in for multiple studies with restrictions and notification with opt-out. We sought to elicit public values in this matter and to work toward an agreement about a common approach to consent for use of personal information for health research through deliberative public dialogues. Methods We conducted seven day-long public dialogues, involving 98 participants across Canada. Immediately before and after each dialogue, participants completed a fixed-response questionnaire rating individuals' support for 3 approaches to consent in the abstract and their consent choices for 5 health research scenarios using personal information. They also rated how confident different safeguards made them feel that their information was being used responsibly. Results Broad opt-in consent for use of personal information garnered the greatest support in the abstract. When presented with specific research scenarios, no one approach to consent predominated. When profit was introduced into the scenarios, consent choices shifted toward greater control over use. Despite lively and constructive dialogues, and considerable shifting in opinion at the individual level, at the end of the day, there was no substantive aggregate movement in opinion. Personal controls were among the most commonly cited approaches to improving people's confidence in the responsible use of their information for research. Conclusion Because no one approach to consent satisfied even a simple majority of dialogue participants and the importance placed on personal controls, a mechanism should be developed for documenting consent choice for different types of research, including ways for individuals to check who has accessed their medical record for purposes other than clinical care. This could be done, for example, through a web-based patient portal to their electronic health record. Researchers and policy makers should continue to engage the public to promote greater public understanding of the research process and to look for feasible alternatives to existing approaches to project-specific consent for observational research. PMID:19019239

Current information technology needs of small to medium sized apparel manufacturers and contractors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wimple, C., LLNL

1998-04-01

This report documents recent efforts of the American Textile Partnership (AMTEX{sup TM}) Demand Activated Manufacturing Architecture (DAMA) Project to identify opportunities for cost effective enhanced information technology use by small to medium sized apparel manufacturers and contractors. Background on the AMTEX/DAMA project and objectives for the specific DAMA Small and Medium Enterprise (SME) effort are discussed in this section. The approach used to gather information about current opportunities or needs is outlined in Section 2 Approach, and relevant findings are identified and a brief analysis of the information gathered is presented in Section 3 Findings. Recommendations based on the analysis,more » are offered in Section 4 Recommendations, and plans are suggested for DAMA follow-on in Section 5 Future Plans. Trip reports for each of the companies visited are contained in Appendix E - Company Trip Reports. These individual reports contain the data upon which the analysis presented in Section 3 Findings is based.« less

The Contribution of Buckwheat Genetic Resources to Health and Dietary Diversity

PubMed Central

Sytar, Oksana; Brestic, Marian; Zivcak, Marek; Tran, Lam-Son Phan

2016-01-01

Despite several reports on the beneficial effects of buckwheat in prevention of human diseases, little attention has been devoted to the variability of biochemical and physiological traits in different buckwheat genetic resources. This review describes the biochemical evaluation of buckwheat genetic resources and the identification of elite genotypes for plant breeding and exploitation. The various types of bioactive compounds present in different varieties provide basic background information needed for the efficient production of buckwheat foods with added value. In this review, we will provide an integrated view of the biochemistry of bioactive compounds of buckwheat plants of different origin, especially of fagopyrin, proteins and amino acids, as well as of other phenolic compounds including rutin and chlorogenic acid. In addition to the genetic background, the effect of different growth conditions is discussed. The health effects of fagopyrin, phenolic acids, specific proteins and rutin are also presented. PMID:27252586

An overview of remote sensing and geodesy for epidemiology and public health application.

PubMed

Hay, S I

2000-01-01

The techniques of remote sensing (RS) and geodesy have the potential to revolutionize the discipline of epidemiology and its application in human health. As a new departure from conventional epidemiological methods, these techniques require some detailed explanation. This review provides the theoretical background to RS including (i) its physical basis, (ii) an explanation of the orbital characteristics and specifications of common satellite sensor systems, (iii) details of image acquisition and procedures adopted to overcome inherent sources of data degradation, and (iv) a background to geophysical data preparation. This information allows RS applications in epidemiology to be readily interpreted. Some of the techniques used in geodesy, to locate features precisely on Earth so that they can be registered to satellite sensor-derived images, are also included. While the basic principles relevant to public health are presented here, inevitably many of the details must be left to specialist texts.

Subject design and factors affecting achievement in mathematics for biomedical science

NASA Astrophysics Data System (ADS)

Carnie, Steven; Morphett, Anthony

2017-01-01

Reports such as Bio2010 emphasize the importance of integrating mathematical modelling skills into undergraduate biology and life science programmes, to ensure students have the skills and knowledge needed for biological research in the twenty-first century. One way to do this is by developing a dedicated mathematics subject to teach modelling and mathematical concepts in biological contexts. We describe such a subject at a research-intensive Australian university, and discuss the considerations informing its design. We also present an investigation into the effect of mathematical and biological background, prior mathematical achievement, and gender, on student achievement in the subject. The investigation shows that several factors known to predict performance in standard calculus subjects apply also to specialized discipline-specific mathematics subjects, and give some insight into the relative importance of mathematical versus biological background for a biology-focused mathematics subject.

An Overview of Remote Sensing and Geodesy for Epidemiology and Public Health Application

PubMed Central

Hay, S.I.

2011-01-01

The techniques of remote sensing (RS) and geodesy have the potential to revolutionize the discipline of epidemiology and its application in human health. As a new departure from conventional epidemiological methods, these techniques require some detailed explanation. This review provides the theoretical background to RS including (i) its physical basis, (ii) an explanation of the orbital characteristics and specifications of common satellite sensor systems, (iii) details of image acquisition and procedures adopted to overcome inherent sources of data degradation, and (iv) a background to geophysical data preparation. This information allows RS applications in epidemiology to be readily interpreted. Some of the techniques used in geodesy, to locate features precisely on Earth so that they can be registered to satellite sensor-derived images, are also included. While the basic principles relevant to public health are presented here, inevitably many of the details must be left to specialist texts. PMID:10997203

Chemical Entity Semantic Specification: Knowledge representation for efficient semantic cheminformatics and facile data integration

PubMed Central

2011-01-01

Background Over the past several centuries, chemistry has permeated virtually every facet of human lifestyle, enriching fields as diverse as medicine, agriculture, manufacturing, warfare, and electronics, among numerous others. Unfortunately, application-specific, incompatible chemical information formats and representation strategies have emerged as a result of such diverse adoption of chemistry. Although a number of efforts have been dedicated to unifying the computational representation of chemical information, disparities between the various chemical databases still persist and stand in the way of cross-domain, interdisciplinary investigations. Through a common syntax and formal semantics, Semantic Web technology offers the ability to accurately represent, integrate, reason about and query across diverse chemical information. Results Here we specify and implement the Chemical Entity Semantic Specification (CHESS) for the representation of polyatomic chemical entities, their substructures, bonds, atoms, and reactions using Semantic Web technologies. CHESS provides means to capture aspects of their corresponding chemical descriptors, connectivity, functional composition, and geometric structure while specifying mechanisms for data provenance. We demonstrate that using our readily extensible specification, it is possible to efficiently integrate multiple disparate chemical data sources, while retaining appropriate correspondence of chemical descriptors, with very little additional effort. We demonstrate the impact of some of our representational decisions on the performance of chemically-aware knowledgebase searching and rudimentary reaction candidate selection. Finally, we provide access to the tools necessary to carry out chemical entity encoding in CHESS, along with a sample knowledgebase. Conclusions By harnessing the power of Semantic Web technologies with CHESS, it is possible to provide a means of facile cross-domain chemical knowledge integration with full preservation of data correspondence and provenance. Our representation builds on existing cheminformatics technologies and, by the virtue of RDF specification, remains flexible and amenable to application- and domain-specific annotations without compromising chemical data integration. We conclude that the adoption of a consistent and semantically-enabled chemical specification is imperative for surviving the coming chemical data deluge and supporting systems science research. PMID:21595881

Students Seeking Access to Four-Year Institutions: Community College Transfers [Background Information].

ERIC Educational Resources Information Center

Moore, Jamillah

This publication provides background information for a hearing by the California Senate Select Committee on Higher Education and Outreach on December 3, 1997. The Introduction presents the Committee announcement, press release, agenda, information about transfer efforts in California, facts and figures about the community colleges, and the text of…

Biana: a software framework for compiling biological interactions and analyzing networks

PubMed Central

2010-01-01

Background The analysis and usage of biological data is hindered by the spread of information across multiple repositories and the difficulties posed by different nomenclature systems and storage formats. In particular, there is an important need for data unification in the study and use of protein-protein interactions. Without good integration strategies, it is difficult to analyze the whole set of available data and its properties. Results We introduce BIANA (Biologic Interactions and Network Analysis), a tool for biological information integration and network management. BIANA is a Python framework designed to achieve two major goals: i) the integration of multiple sources of biological information, including biological entities and their relationships, and ii) the management of biological information as a network where entities are nodes and relationships are edges. Moreover, BIANA uses properties of proteins and genes to infer latent biomolecular relationships by transferring edges to entities sharing similar properties. BIANA is also provided as a plugin for Cytoscape, which allows users to visualize and interactively manage the data. A web interface to BIANA providing basic functionalities is also available. The software can be downloaded under GNU GPL license from http://sbi.imim.es/web/BIANA.php. Conclusions BIANA's approach to data unification solves many of the nomenclature issues common to systems dealing with biological data. BIANA can easily be extended to handle new specific data repositories and new specific data types. The unification protocol allows BIANA to be a flexible tool suitable for different user requirements: non-expert users can use a suggested unification protocol while expert users can define their own specific unification rules. PMID:20105306

Access to and value of information to support good practice for staff in Kenyan hospitals

PubMed Central

Muinga, Naomi; Sen, Barbara; Ayieko, Philip; Todd, Jim; English, Mike

2015-01-01

Background Studies have sought to define information needs of health workers within very specific settings or projects. Lacking in the literature is how hospitals in low-income settings are able to meet the information needs of their staff and the use of information communication technologies (ICT) in day-to-day information searching. Objective The study aimed to explore where professionals in Kenyan hospitals turn to for work-related information in their day-to-day work. Additionally, it examined what existing solutions are provided by hospitals with regard to provision of best practice care. Lastly, the study explored the use of ICT in information searching. Design Data for this study were collected in July 2012. Self-administered questionnaires (SAQs) were distributed across 22 study hospitals with an aim to get a response from 34 health workers per hospital. Results SAQs were collected from 657 health workers. The most popular sources of information to guide work were fellow health workers and printed guidelines while the least popular were scientific journals. Of value to health workers were: national treatment policies, new research findings, regular reports from surveillance data, information on costs of services and information on their performance of routine clinical tasks; however, hospitals only partially met these needs. Barriers to accessing information sources included: ‘not available/difficult to get’ and ‘difficult to understand’. ICT use for information seeking was reported and with demographic specific differences noted from the multivariate logistic regression model; nurses compared to medical doctors and older workers were less likely to use ICT for health information searching. Barriers to accessing Internet were identified as: high costs and the lack of the service at home or at work. Conclusions Hospitals need to provide appropriate information by improving information dissemination efforts and providing an enabling environment that allows health workers find the information they need for best practice. PMID:25979113

Informational Masking Effects on Neural Encoding of Stimulus Onset and Acoustic Change.

PubMed

Niemczak, Christopher E; Vander Werff, Kathy R

2018-05-18

Recent investigations using cortical auditory evoked potentials have shown masker-dependent effects on sensory cortical processing of speech information. Background noise maskers consisting of other people talking are particularly difficult for speech recognition. Behavioral studies have related this to perceptual masking, or informational masking, beyond just the overlap of the masker and target at the auditory periphery. The aim of the present study was to use cortical auditory evoked potentials, to examine how maskers (i.e., continuous speech-shaped noise [SSN] and multi-talker babble) affect the cortical sensory encoding of speech information at an obligatory level of processing. Specifically, cortical responses to vowel onset and formant change were recorded under different background noise conditions presumed to represent varying amounts of energetic or informational masking. The hypothesis was, that even at this obligatory cortical level of sensory processing, we would observe larger effects on the amplitude and latency of the onset and change components as the amount of informational masking increased across background noise conditions. Onset and change responses were recorded to a vowel change from /u-i/ in young adults under four conditions: quiet, continuous SSN, eight-talker (8T) babble, and two-talker (2T) babble. Repeated measures analyses by noise condition were conducted on amplitude, latency, and response area measurements to determine the differential effects of these noise conditions, designed to represent increasing and varying levels of informational and energetic masking, on cortical neural representation of a vowel onset and acoustic change response waveforms. All noise conditions significantly reduced onset N1 and P2 amplitudes, onset N1-P2 peak to peak amplitudes, as well as both onset and change response area compared with quiet conditions. Further, all amplitude and area measures were significantly reduced for the two babble conditions compared with continuous SSN. However, there were no significant differences in peak amplitude or area for either onset or change responses between the two different babble conditions (eight versus two talkers). Mean latencies for all onset peaks were delayed for noise conditions compared with quiet. However, in contrast to the amplitude and area results, differences in peak latency between SSN and the babble conditions did not reach statistical significance. These results support the idea that while background noise maskers generally reduce amplitude and increase latency of speech-sound evoked cortical responses, the type of masking has a significant influence. Speech babble maskers (eight talkers and two talkers) have a larger effect on the obligatory cortical response to speech sound onset and change compared with purely energetic continuous SSN maskers, which may be attributed to informational masking effects. Neither the neural responses to the onset nor the vowel change, however, were sensitive to the hypothesized increase in the amount of informational masking between speech babble maskers with two talkers compared with eight talkers.

The Importance of Purpose: Moving beyond Consent in the Societal Use of Personal Health Information

PubMed Central

Grande, David; Mitra, Nandita; Shah, Anand; Wan, Fei; Asch, David A.

2015-01-01

Background Adoption of electronic health record systems has increased the availability of patient-level electronic health information. Objective Examine public support for secondary uses of electronic health information under different consent arrangements. Design National experimental survey to examine perceptions of uses of electronic health information when varying along three dimensions: patient consent (obtained vs. not obtained), use (research vs. marketing), and framing of the findings (abstract description without results vs. specific results). Setting Nationally representative survey. Participants 3,064 African American, Hispanic, and non-Hispanic White individuals representing a response rate of 65%. Measurements Appropriateness of health information use described in vignettes on a 1-10 scale (1=not at all appropriate; 10=very appropriate). Results Mean ratings ranged from a low of 3.81 for a marketing use when consent was not obtained and specific results were presented to a high of 7.06 for a research use when consent was obtained and specific results were presented. Participants rated scenarios where consent was obtained as more appropriate compared to when consent was not obtained (+1.01; 95% CI 0.69, 1.34, P<0.001). Participants rated scenarios where the use was marketing as less appropriate compared to when the use was research (−2.03; 95% CI −2.27, −1.78, P<0.001). Unconsented research uses were seen as more appropriate than consented marketing uses (5.65 vs. 4.52; difference = 1.13; 95% CI 0.87, 1.39).. Limitations Participants rated hypothetical scenarios and results could be vulnerable to non-response bias despite the high response rate. Conclusions Although approaches to health information sharing emphasize consent, public opinion also emphasizes purpose suggesting a need to focus more attention on the social value of information use. Primary Funding Source National Human Genome Research Institute PMID:25506854

Annotated ESTs from various tissues of the brown planthopper Nilaparvata lugens: A genomic resource for studying agricultural pests

PubMed Central

Noda, Hiroaki; Kawai, Sawako; Koizumi, Yoko; Matsui, Kageaki; Zhang, Qiang; Furukawa, Shigetoyo; Shimomura, Michihiko; Mita, Kazuei

2008-01-01

Background The brown planthopper (BPH), Nilaparvata lugens (Hemiptera, Delphacidae), is a serious insect pests of rice plants. Major means of BPH control are application of agricultural chemicals and cultivation of BPH resistant rice varieties. Nevertheless, BPH strains that are resistant to agricultural chemicals have developed, and BPH strains have appeared that are virulent against the resistant rice varieties. Expressed sequence tag (EST) analysis and related applications are useful to elucidate the mechanisms of resistance and virulence and to reveal physiological aspects of this non-model insect, with its poorly understood genetic background. Results More than 37,000 high-quality ESTs, excluding sequences of mitochondrial genome, microbial genomes, and rDNA, have been produced from 18 libraries of various BPH tissues and stages. About 10,200 clusters have been made from whole EST sequences, with average EST size of 627 bp. Among the top ten most abundantly expressed genes, three are unique and show no homology in BLAST searches. The actin gene was highly expressed in BPH, especially in the thorax. Tissue-specifically expressed genes were extracted based on the expression frequency among the libraries. An EST database is available at our web site. Conclusion The EST library will provide useful information for transcriptional analyses, proteomic analyses, and gene functional analyses of BPH. Moreover, specific genes for hemimetabolous insects will be identified. The microarray fabricated based on the EST information will be useful for finding genes related to agricultural and biological problems related to this pest. PMID:18315884

Early evolution of efficient enzymes and genome organization

PubMed Central

2012-01-01

Background Cellular life with complex metabolism probably evolved during the reign of RNA, when it served as both information carrier and enzyme. Jensen proposed that enzymes of primordial cells possessed broad specificities: they were generalist. When and under what conditions could primordial metabolism run by generalist enzymes evolve to contemporary-type metabolism run by specific enzymes? Results Here we show by numerical simulation of an enzyme-catalyzed reaction chain that specialist enzymes spread after the invention of the chromosome because protocells harbouring unlinked genes maintain largely non-specific enzymes to reduce their assortment load. When genes are linked on chromosomes, high enzyme specificity evolves because it increases biomass production, also by reducing taxation by side reactions. Conclusion The constitution of the genetic system has a profound influence on the limits of metabolic efficiency. The major evolutionary transition to chromosomes is thus proven to be a prerequisite for a complex metabolism. Furthermore, the appearance of specific enzymes opens the door for the evolution of their regulation. Reviewers This article was reviewed by Sándor Pongor, Gáspár Jékely, and Rob Knight. PMID:23114029

3D brain tumor segmentation in multimodal MR images based on learning population- and patient-specific feature sets.

PubMed

Jiang, Jun; Wu, Yao; Huang, Meiyan; Yang, Wei; Chen, Wufan; Feng, Qianjin

2013-01-01

Brain tumor segmentation is a clinical requirement for brain tumor diagnosis and radiotherapy planning. Automating this process is a challenging task due to the high diversity in appearance of tumor tissue among different patients and the ambiguous boundaries of lesions. In this paper, we propose a method to construct a graph by learning the population- and patient-specific feature sets of multimodal magnetic resonance (MR) images and by utilizing the graph-cut to achieve a final segmentation. The probabilities of each pixel that belongs to the foreground (tumor) and the background are estimated by global and custom classifiers that are trained through learning population- and patient-specific feature sets, respectively. The proposed method is evaluated using 23 glioma image sequences, and the segmentation results are compared with other approaches. The encouraging evaluation results obtained, i.e., DSC (84.5%), Jaccard (74.1%), sensitivity (87.2%), and specificity (83.1%), show that the proposed method can effectively make use of both population- and patient-specific information. Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved.

Regional specific groundwater arsenic levels and neuropsychological functioning: a cross-sectional study

PubMed Central

Edwards, Melissa; Johnson, Leigh; Mauer, Cortney; Barber, Robert; Hall, James; O'Bryant, Sid

2014-01-01

Background The purpose of the study was to examine the link between GIS-estimated regional specific groundwater levels and neuropsychological functioning in a sample of individuals with and without cognitive impairment. Methods This cross-sectional study design analyzed data from 1390 participants (733 Alzheimer's disease, 127 Mild Cognitive Impairment, and 530 with normal cognition) enrolled in the Texas Alzheimer's Research and Care Consortium. Geographic information systems analyses were used to estimate regional specific groundwater arsenic concentrations using the Environmental Systems Research Institute and arsenic concentrations from the Texas Water Development Board. Results In the full cohort, regional specific arsenic concentrations were positively associated with language abilities (p=0.008), but associated with poorer verbal memory, immediate (p=0.008) and delayed (p<0.001) as well as poorer visual memory, immediate (p=0.02) and delayed (p<0.001). The findings varied by diagnostic category with arsenic being related with cognition most prominently among MCI cases. Conclusions Overall, estimated regional specific groundwater arsenic levels were negatively associated with neuropsychological performance. PMID:24506178

Latina immigrants, interpersonal violence, and the decision to report to police.

PubMed

Pitts, Kimberly Mathis

2014-06-01

Interpersonal violence (IPV) occurs across all ethnic and racial groups and affects women of all ages and socioeconomic backgrounds. Battered women of Latin American descent are less likely to seek help from either formal or informal sources and these women are more likely to stay longer in an abusive relationship before seeking help. To contribute to the growing body of literature on IPV, this research will examine particular situational and individual-specific characteristics of IPV incidents experienced by Latina immigrant women living in a metropolitan area in the Southern United States. Based on a sample of 568 immigrant Latina women collected over a 6-year period, this research explains whether particular situational and individual-specific characteristics of IPV incidents affect the decisions of Latina victims to report to the police.

COMPENDIUM OF METHODS FOR THE DETERMINATION ...

EPA Pesticide Factsheets

This Second Edition of the Compendium has been prepared to provide regional, state and local environmental regulatory agencies with step-by-step sampling and analysis procedures for the determination of selected toxic organic pollutants in ambient air. It is designed to assist those persons responsible for sampling and analysis of toxic organic pollutants in complying with the requirements of Title III of the Clean Air Act. This revised Compendium presents a set of 17 methods in a standardized format with a variety of applicable sampling methods, as well as several analytical techniques, for specific classes of organic pollutants, as appropriate to the specific pollutant compound, its level, and potential interferences. Consequently, this treatment allows the user flexibility in selecting alternatives to complement his or her background and laboratory capability. Information

Questions about complementary and alternative medicine to the Regional Medicines Information and Pharmacovigilance Centres in Norway (RELIS): a descriptive pilot study

PubMed Central

2014-01-01

Background Provision of clinically relevant information about complementary and alternative medicine (CAM) to health care professionals is not well described. The aim of the study was to assess questions about CAM to the Regional Medicines Information and Pharmacovigilance Centres in Norway (RELIS). Methods All question-answers pairs (QAPs) in the RELIS database indexed with alternative medicine from 2005-2010 constituted the study material. A randomly selected sample of 100 QAPs was characterized with regard to type of question (category, patient-specific or general), occupation and workplace of enquirer, the type of information search performed (simple or advanced), and if the answers contained information to provide factual or consultative replies (facts about or advice on clinical use of CAM, respectively). Proportions were compared with Fisher’s exact test with significance at the 0.05 level. Results One thousand and thirty-eight (7.7%) out of 13 482 questions involved CAM. Eighty-two out of 100 questions concerned products containing one or more herbs, vitamins and minerals as well as other substances. Thirty-eight out of 100 questions concerned the category documentation (substance identification and/or literature reports about clinical effects), 36 interactions, 16 adverse effects, 9 pregnancy and lactation, and 1 question concerned contraindications. Sixty-three questions were patient-specific and 37 general. Fifty-four questions came from physicians, 33 from pharmacists and 13 from others (including nurses, midwives, students, CAM practitioners, and the public). Pharmacists asked more frequently about interactions while physicians asked more frequently about adverse effects (p < 0.05). Seventy-six of the questions came from outside hospital, mainly general practice and community pharmacies. Fifty-nine answers were based on a simple and 41 on an advanced information search. Thirty-three factual and 38 consultative answers were provided. In 29 answers, search provided no information. Lack of information to provide an answer was not significantly different between patient-specific (31.7%) and general questions (24.3%). Conclusions General practice and community pharmacies are the main sources for questions about CAM to RELIS. Physicians are concerned about adverse effects while pharmacists are concerned about interactions. Lack of information to provide answers to patient-specific and general questions about CAM represents a problem. PMID:24529279

Genetic dissection of quantitative trait locus for ethanol sensitivity in long- and short-sleep mice.

PubMed

Bennett, B; Carosone-Link, P; Beeson, M; Gordon, L; Phares-Zook, N; Johnson, T E

2008-08-01

Interval-specific congenic strains (ISCS) allow fine mapping of a quantitative trait locus (QTL), narrowing its confidence interval by an order of magnitude or more. In earlier work, we mapped four QTL specifying differential ethanol sensitivity, assessed by loss of righting reflex because of ethanol (LORE), in the inbred long-sleep (ILS) and inbred short-sleep (ISS) strains, accounting for approximately 50% of the genetic variance for this trait. Subsequently, we generated reciprocal congenic strains in which each full QTL interval from ILS was bred onto the ISS background and vice versa. An earlier paper reported construction and results of the ISCS on the ISS background; here, we describe this process and report results on the ILS background. We developed multiple ISCS for each Lore QTL in which the QTL interval was broken into a number of smaller intervals. For each of the four QTL regions (chromosomes 1, 2, 11 and 15), we were successful in reducing the intervals significantly. Multiple, positive strains were overlapped to generate a single, reduced interval. Subsequently, this reduced region was overlaid on previous reductions from the ISS background congenics, resulting in substantial reductions in all QTL regions by approximately 75% from the initial mapping study. Genes with sequence or expression polymorphisms in the reduced intervals are potential candidates; evidence for these is presented. Genetic background effects can be important in detection of single QTL; combining this information with the generation of congenics on both backgrounds, as described here, is a powerful approach for fine mapping QTL.

Content specificity of attentional bias to threat in post-traumatic stress disorder.

PubMed

Zinchenko, A; Al-Amin, M M; Alam, M M; Mahmud, W; Kabir, N; Reza, H M; Burne, T H J

2017-08-01

Attentional bias to affective information and reduced cognitive control may maintain the symptoms of post-traumatic stress disorder (PTSD) and impair cognitive functioning. However, the role of content specificity of affective stimuli (e.g., trauma-related, emotional trauma-unrelated) in the observed attentional bias and cognitive control is less clear, as this has not been tested simultaneously before. Therefore, we examined the content specificity of attentional bias to threat in PTSD. PTSD participants (survivors of a multistory factory collapse, n=30) and matched controls (n=30) performed an Eriksen Flanker task. They identified the direction of a centrally presented target arrow, which was flanked by several task-irrelevant distractor arrows pointed to the same (congruent) or opposite direction (incongruent). Additionally, participants were presented with a picture of a face (neutral, emotional) or building (neutral=normal, emotional=collapsed multistory factory) as a task-irrelevant background image. We found that PTSD participants produced overall larger conflict effects and longer reaction times (RT) to emotional than to neutral stimuli relative to their healthy counterparts. Moreover, PTSD, but not healthy participants showed a stimulus specific dissociation in processing emotional stimuli. Emotional faces elicited longer RTs compared to neutral faces, while emotional buildings elicited faster responses, compared to neutral buildings. PTSD patients show a content-sensitive attentional bias to emotional information and impaired cognitive control. Copyright © 2017 Elsevier Ltd. All rights reserved.

Employment of Near Full-Length Ribosome Gene TA-Cloning and Primer-Blast to Detect Multiple Species in a Natural Complex Microbial Community Using Species-Specific Primers Designed with Their Genome Sequences.

PubMed

Zhang, Huimin; He, Hongkui; Yu, Xiujuan; Xu, Zhaohui; Zhang, Zhizhou

2016-11-01

It remains an unsolved problem to quantify a natural microbial community by rapidly and conveniently measuring multiple species with functional significance. Most widely used high throughput next-generation sequencing methods can only generate information mainly for genus-level taxonomic identification and quantification, and detection of multiple species in a complex microbial community is still heavily dependent on approaches based on near full-length ribosome RNA gene or genome sequence information. In this study, we used near full-length rRNA gene library sequencing plus Primer-Blast to design species-specific primers based on whole microbial genome sequences. The primers were intended to be specific at the species level within relevant microbial communities, i.e., a defined genomics background. The primers were tested with samples collected from the Daqu (also called fermentation starters) and pit mud of a traditional Chinese liquor production plant. Sixteen pairs of primers were found to be suitable for identification of individual species. Among them, seven pairs were chosen to measure the abundance of microbial species through quantitative PCR. The combination of near full-length ribosome RNA gene library sequencing and Primer-Blast may represent a broadly useful protocol to quantify multiple species in complex microbial population samples with species-specific primers.

Experiences with nutrition-related information during antenatal care of pregnant women of different ethnic backgrounds residing in the area of Oslo, Norway.

PubMed

Garnweidner, Lisa M; Sverre Pettersen, Kjell; Mosdøl, Annhild

2013-12-01

to explore experiences with nutrition-related information during routine antenatal care among women of different ethnical backgrounds. individual interviews with seventeen participants were conducted twice during pregnancy. Data collection and analysis were inspired by an interpretative phenomenological approach. participants were purposively recruited at eight Mother and Child Health Centres in the area of Oslo, Norway, where they received antenatal care. participants had either immigrant backgrounds from African and Asian countries (n=12) or were ethnic Norwegian (n=5). Participants were pregnant with their first child and had a pre-pregnancy Body Mass Index above 25 kg/m(2). participants experienced that they were provided with little nutrition-related information in antenatal care. The information was perceived as presented in very general terms and focused on food safety. Weight management and the long-term prevention of diet-related chronic diseases had hardly been discussed. Participants with immigrant backgrounds appeared to be confused about information given by the midwife which was incongruent with their original food culture. The participants were actively seeking for nutrition-related information and had to navigate between various sources of information. the midwife is considered a trustworthy source of nutrition-related information. Therefore, antenatal care may have considerable potential to promote a healthy diet to pregnant women. Findings suggest that nutrition communication in antenatal care should be more tailored towards women's dietary habits and cultural background, nutritional knowledge as well as level of nutrition literacy. Copyright © 2012 Elsevier Ltd. All rights reserved.

Using expert knowledge for test linking.

PubMed

Bolsinova, Maria; Hoijtink, Herbert; Vermeulen, Jorine Adinda; Béguin, Anton

2017-12-01

Linking and equating procedures are used to make the results of different test forms comparable. In the cases where no assumption of random equivalent groups can be made some form of linking design is used. In practice the amount of data available to link the two tests is often very limited due to logistic and security reasons, which affects the precision of linking procedures. This study proposes to enhance the quality of linking procedures based on sparse data by using Bayesian methods which combine the information in the linking data with background information captured in informative prior distributions. We propose two methods for the elicitation of prior knowledge about the difference in difficulty of two tests from subject-matter experts and explain how these results can be used in the specification of priors. To illustrate the proposed methods and evaluate the quality of linking with and without informative priors, an empirical example of linking primary school mathematics tests is presented. The results suggest that informative priors can increase the precision of linking without decreasing the accuracy. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

ACCESS, SOURCES AND VALUE OF NEW MEDICAL INFORMATION - VIEWS OF FINAL YEAR MEDICAL STUDENTS AT THE UNIVERSITY OF NAIROBI

PubMed Central

Gituma, Adrian; Masika, Moses; Muchangi, Eric; Nyagah, Lily; Otieno, Vincent; Irimu, Grace; Wasunna, Aggrey; Ndiritu, Moses; English, Mike

2009-01-01

Background Globally many doctors, particularly in low-income countries, have no formal training in using new information to improve their practice. As a first step clinicians must have access to information and so we explored reported access in graduating medical students in Nairobi. Objectives To evaluate final year medical students’ access to new medical information. Methods A cross-sectional survey of fifth (final) year medical students at the University of Nairobi using anonymous, self-administered questionnaires. Findings Questionnaires were distributed to 291 (85%) of a possible 343 students and returned by 152 (44%). Within the previous 12 months half reported accessing some form of new medical information most commonly from books and the internet. However, only a small number reported regular access and specific, new journal articles were rarely accessed. Absence of internet facilities, slow internet speeds and cost were common barriers to access while current training seems rarely to encourage students to seek new information. Conclusion Almost half the students had not accessed any new medical information in their final year in medical school suggesting they are ill prepared for a career that may increasingly demand life-long, self-learning. PMID:19152558

Oxytocin Reduces Background Anxiety in a Fear-Potentiated Startle Paradigm: Peripheral vs Central Administration

PubMed Central

Ayers, Luke W; Missig, Galen; Schulkin, Jay; Rosen, Jeffrey B

2011-01-01

Oxytocin is known to have anti-anxiety and anti-stress effects. Using a fear-potentiated startle paradigm in rats, we previously demonstrated that subcutaneously administered oxytocin suppressed acoustic startle following fear conditioning compared with startle before fear conditioning (termed background anxiety), but did not have an effect on cue-specific fear-potentiated startle. The findings suggest oxytocin reduces background anxiety, an anxious state not directly related to cue-specific fear, but sustained beyond the immediate threat. The goal of the present study was to compare the effects of centrally and peripherally administered oxytocin on background anxiety and cue-specific fear. Male rats were given oxytocin either subcutaneously (SC) or intracerebroventricularly (ICV) into the lateral ventricles before fear-potentiated startle testing. Oxytocin doses of 0.01 and 0.1 μg/kg SC reduced background anxiety. ICV administration of oxytocin at doses from 0.002 to 20 μg oxytocin had no effect on background anxiety or cue-specific fear-potentiated startle. The 20 μg ICV dose of oxytocin did reduce acoustic startle in non-fear conditioned rats. These studies indicate that oxytocin is potent and effective in reducing background anxiety when delivered peripherally, but not when delivered into the cerebroventricular system. Oxytocin given systemically may have anti-anxiety properties that are particularly germane to the hypervigilance and exaggerated startle typically seen in many anxiety and mental health disorder patients. PMID:21796104

A case study for teaching information literacy skills

PubMed Central

Kingsley, Karla V; Kingsley, Karl

2009-01-01

Background The Internet has changed contemporary workplace skills, resulting in a need for proficiency with specific digital, online and web-based technologies within the fields of medicine, dentistry and public health. Although younger students, generally under 30 years of age, may appear inherently comfortable with the use of technology-intensive environments and digital or online search methods, competence in information literacy among these students may be lacking. Methods This project involved the design and assessment of a research-based assignment to help first-year, graduate-level health science students to develop and integrate information literacy skills with clinical relevance. Results One cohort of dental students (n = 78) was evaluated for this project and the results demonstrate that although all students were able to provide the correct response from the content-specific, or technology-independent, portion of the assignment, more than half (54%) were unable to demonstrate competence with a web-based, technology-dependent section of this assignment. No correlation was found between any demographic variable measured (gender, age, or race). Conclusion More evidence is emerging that demonstrates the need for developing curricula that integrates new knowledge and current evidence-based practices and technologies, traditionally isolated from graduate and health-care curricula, that can enhance biomedical and clinical training for students. This study provides evidence, critical for the evaluation of new practices, which can promote and facilitate the integration of information literacy into the curriculum. PMID:19178715

Retrieval of Radiology Reports Citing Critical Findings with Disease-Specific Customization

PubMed Central

Lacson, Ronilda; Sugarbaker, Nathanael; Prevedello, Luciano M; Ivan, IP; Mar, Wendy; Andriole, Katherine P; Khorasani, Ramin

2012-01-01

Background: Communication of critical results from diagnostic procedures between caregivers is a Joint Commission national patient safety goal. Evaluating critical result communication often requires manual analysis of voluminous data, especially when reviewing unstructured textual results of radiologic findings. Information retrieval (IR) tools can facilitate this process by enabling automated retrieval of radiology reports that cite critical imaging findings. However, IR tools that have been developed for one disease or imaging modality often need substantial reconfiguration before they can be utilized for another disease entity. Purpose: This paper: 1) describes the process of customizing two Natural Language Processing (NLP) and Information Retrieval/Extraction applications – an open-source toolkit, A Nearly New Information Extraction system (ANNIE); and an application developed in-house, Information for Searching Content with an Ontology-Utilizing Toolkit (iSCOUT) – to illustrate the varying levels of customization required for different disease entities and; 2) evaluates each application’s performance in identifying and retrieving radiology reports citing critical imaging findings for three distinct diseases, pulmonary nodule, pneumothorax, and pulmonary embolus. Results: Both applications can be utilized for retrieval. iSCOUT and ANNIE had precision values between 0.90-0.98 and recall values between 0.79 and 0.94. ANNIE had consistently higher precision but required more customization. Conclusion: Understanding the customizations involved in utilizing NLP applications for various diseases will enable users to select the most suitable tool for specific tasks. PMID:22934127

Satellite data driven modeling system for predicting air quality and visibility during wildfire and prescribed burn events

NASA Astrophysics Data System (ADS)

Nair, U. S.; Keiser, K.; Wu, Y.; Maskey, M.; Berendes, D.; Glass, P.; Dhakal, A.; Christopher, S. A.

2012-12-01

The Alabama Forestry Commission (AFC) is responsible for wildfire control and also prescribed burn management in the state of Alabama. Visibility and air quality degradation resulting from smoke are two pieces of information that are crucial for this activity. Currently the tools available to AFC are the dispersion index available from the National Weather Service and also surface smoke concentrations. The former provides broad guidance for prescribed burning activities but does not provide specific information regarding smoke transport, areas affected and quantification of air quality and visibility degradation. While the NOAA operational air quality guidance includes surface smoke concentrations from existing fire events, it does not account for contributions from background aerosols, which are important for the southeastern region including Alabama. Also lacking is the quantification of visibility. The University of Alabama in Huntsville has developed a state-of-the-art integrated modeling system to address these concerns. This system based on the Community Air Quality Modeling System (CMAQ) that ingests satellite derived smoke emissions and also assimilates NASA MODIS derived aerosol optical thickness. In addition, this operational modeling system also simulates the impact of potential prescribed burn events based on location information derived from the AFC prescribed burn permit database. A lagrangian model is used to simulate smoke plumes for the prescribed burns requests. The combined air quality and visibility degradation resulting from these smoke plumes and background aerosols is computed and the information is made available through a web based decision support system utilizing open source GIS components. This system provides information regarding intersections between highways and other critical facilities such as old age homes, hospitals and schools. The system also includes satellite detected fire locations and other satellite derived datasets relevant for fire and smoke management.

A study of nuclear recoil backgrounds in dark matter detectors

NASA Astrophysics Data System (ADS)

Westerdale, Shawn S.

Despite the great success of the Standard Model of particle physics, a preponderance of astrophysical evidence suggests that it cannot explain most of the matter in the universe. This so-called dark matter has eluded direct detection, though many theoretical extensions to the Standard Model predict the existence of particles with a mass on the 1-1000 GeV scale that interact only via the weak nuclear force. Particles in this class are referred to as Weakly Interacting Massive Particles (WIMPs), and their high masses and low scattering cross sections make them viable dark matter candidates. The rarity of WIMP-nucleus interactions makes them challenging to detect: any background can mask the signal they produce. Background rejection is therefore a major problem in dark matter detection. Many experiments greatly reduce their backgrounds by employing techniques to reject electron recoils. However, nuclear recoil backgrounds, which produce signals similar to what we expect from WIMPs, remain problematic. There are two primary sources of such backgrounds: surface backgrounds and neutron recoils. Surface backgrounds result from radioactivity on the inner surfaces of the detector sending recoiling nuclei into the detector. These backgrounds can be removed with fiducial cuts, at some cost to the experiment's exposure. In this dissertation we briefly discuss a novel technique for rejecting these events based on signals they make in the wavelength shifter coating on the inner surfaces of some detectors. Neutron recoils result from neutrons scattering off of nuclei in the detector. These backgrounds may produce a signal identical to what we expect from WIMPs and are extensively discussed here. We additionally present a new tool for calculating (alpha, n) yields in various materials. We introduce the concept of a neutron veto system designed to shield against, measure, and provide an anti-coincidence veto signal for background neutrons. We discuss the research and development that informed the design of the DarkSide-50 boron-loaded liquid scintillator neutron veto. We describe the specific implementation of this veto system in DarkSide-50, including a description of its performance, and show that it can reject neutrons with a high enough efficiency to allow DarkSide-50 to run background-free for three years.

Persistence and evolution of allergen-specific IgE repertoires during subcutaneous specific immunotherapy

PubMed Central

Levin, Mattias; King, Jasmine J.; Glanville, Jacob; Jackson, Katherine J. L.; Looney, Timothy J.; Hoh, Ramona A.; Mari, Adriano; Andersson, Morgan; Greiff, Lennart; Fire, Andrew Z.; Boyd, Scott D.; Ohlin, Mats

2016-01-01

Background Specific immunotherapy (SIT) is the only treatment with proven long-term curative potential in allergic disease. Allergen-specific IgE is the causative agent of allergic disease, and antibodies contribute to SIT, but the effects of SIT on aeroallergen-specific B cell repertoires are not well understood. Objective To characterize the IgE sequences expressed by allergen-specific B cells, and track the fate of these B cell clones during SIT. Methods We have used high-throughput antibody gene sequencing and identification of allergen-specific IgE using combinatorial antibody fragment library technology to analyze immunoglobulin repertoires of blood and nasal mucosa of aeroallergen-sensitized individuals before and during the first year of subcutaneous SIT. Results Of 52 distinct allergen-specific IgE heavy chains from eight allergic donors, 37 were also detected by high-throughput antibody gene sequencing of blood, nasal mucosa, or both sample types. The allergen-specific clones had increased persistence, higher likelihood of belonging to clones expressing other switched isotypes, and possibly larger clone size than the rest of the IgE repertoire. Clone members in nasal tissue showed close mutational relationships. Conclusion Combining functional binding studies, deep antibody repertoire sequencing, and information on clinical outcomes in larger studies may in the future aid assessment of SIT mechanisms and efficacy. PMID:26559321

Antiretroviral therapy outcomes among HIV infected clients in Gweru City, Zimbabwe 2006 - 2011: a cohort analysis.

PubMed

Shambira, Gerald; Gombe, Notion Tafara; Hall, Casey Daniel; Park, Meeyoung Mattie; Frimpong, Joseph Asamoah

2017-01-01

The government of Zimbabwe began providing antiretroviral therapy (ART) to People Living with HIV/AIDS (PLHIV) in public institutions in 2004. In Midlands province two clinics constituted the most active HIV care service points, with patients being followed up through a comprehensive patient monitoring and tracking system which captured specific patient variables and outcomes over time. The data from 2006 to 2011 were subjected to analysis to answer specific research questions and this case study is based on that analysis. The goal of this case study is to build participants' capacity to undertake secondary data analysis and interpretation using a dataset for HIV antiretroviral therapy in Zimbabwe and to draw conclusions which inform recommendations. Case studies in applied epidemiology allow students to practice applying epidemiologic skills in the classroom to address real-world public health problems. Case studies as a vital component of an applied epidemiology curriculum are instrumental in reinforcing principles and skills covered in lectures or in background reading. The target audience includes Field Epidemiology and Laboratory Training Programs (FELTPs), university students, district health executives, and health information officers.

VarioML framework for comprehensive variation data representation and exchange

PubMed Central

2012-01-01

Background Sharing of data about variation and the associated phenotypes is a critical need, yet variant information can be arbitrarily complex, making a single standard vocabulary elusive and re-formatting difficult. Complex standards have proven too time-consuming to implement. Results The GEN2PHEN project addressed these difficulties by developing a comprehensive data model for capturing biomedical observations, Observ-OM, and building the VarioML format around it. VarioML pairs a simplified open specification for describing variants, with a toolkit for adapting the specification into one's own research workflow. Straightforward variant data can be captured, federated, and exchanged with no overhead; more complex data can be described, without loss of compatibility. The open specification enables push-button submission to gene variant databases (LSDBs) e.g., the Leiden Open Variation Database, using the Cafe Variome data publishing service, while VarioML bidirectionally transforms data between XML and web-application code formats, opening up new possibilities for open source web applications building on shared data. A Java implementation toolkit makes VarioML easily integrated into biomedical applications. VarioML is designed primarily for LSDB data submission and transfer scenarios, but can also be used as a standard variation data format for JSON and XML document databases and user interface components. Conclusions VarioML is a set of tools and practices improving the availability, quality, and comprehensibility of human variation information. It enables researchers, diagnostic laboratories, and clinics to share that information with ease, clarity, and without ambiguity. PMID:23031277

Meta-Analysis of Personality Traits in Alzheimer’s Disease: A Comparison with Healthy Subjects

PubMed Central

D’Iorio, Alfonsina; Garramone, Federica; Piscopo, Fausta; Baiano, Chiara; Raimo, Simona; Santangelo, Gabriella

2018-01-01

Background: The role of specific personality traits as factor risks of Alzheimer’s disease (AD) has been consistently found, whereas personality traits specifically related to AD (after the diagnosis) have not been outlined yet. Objective: A meta-analysis of published studies was performed to determine whether AD patients have a distinctive personality trait profile compared to healthy subjects (HC), similar to or different from a premorbid personality profile consistently reported in previous studies. Methods: A systematic literature search was performed using PsycInfo (PROQUEST), PubMed, and Scopus. The meta-analysis pooled results from primary studies using Hedges’ g unbiased approach. Results: The meta-analysis included 10 primary studies and revealed that, when the personality was evaluated by informant-rated measures, AD patients had significantly higher levels of Neuroticism, lower levels of Openness, Agreeableness, Conscientiousness, and Extraversion than HCs. When the personality was evaluated by self-rated measures, the results obtained from informants were confirmed for Neuroticism, Openness, and Extraversion but not for Agreeableness and Conscientiousness where AD patients and HCs achieved similar scores. Conclusions: The meta-analysis revealed that high Neuroticism and low Openness and Extraversion are distinctive personality traits significantly associated with a diagnosis of AD when evaluated both self-rated and informant-rated measures. This personality trait profile is similar to premorbid one, which contributes to development of AD over time. Therefore, our findings indirectly support the idea of specific premorbid personality traits as harbingers of AD. PMID:29480186

Modular, high power, variable R dynamic electrical load simulator

NASA Technical Reports Server (NTRS)

Joncas, K. P.

1974-01-01

The design of a previously developed basic variable R load simulator was entended to increase its power dissipation and transient handling capabilities. The delivered units satisfy all design requirements, and provides for a high power, modular simulation capability uniquely suited to the simulation of complex load responses. In addition to presenting conclusions and recommendations and pertinent background information, the report covers program accomplishments; describes the simulator basic circuits, transfer characteristic, protective features, assembly, and specifications; indicates the results of simulator evaluation, including burn-in and acceptance testing; provides acceptance test data; and summarizes the monthly progress reports.

Key issues concerning environmental enrichment for laboratory-held fish species.

PubMed

Williams, T D; Readman, G D; Owen, S F

2009-04-01

An improved knowledge and understanding of the fundamental biological requirements is needed for many of the species of fish held in captivity and, without this knowledge it is difficult to determine the optimal conditions for laboratory culture. The aim of this paper is to review the key issues concerning environmental enrichment for laboratory-held fish species and identify where improvements are required. It provides background information on environmental enrichment, describes enrichment techniques currently used in aquatic ecotoxicology studies, identifies potential restrictions in their use and discusses why more detailed and species-specific guidance is needed.

Chapter 7: Renewable Energy Options and Considerations for Net Zero Installations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Booth, Samuel

This chapter focuses on renewable energy options for military installations. It discusses typical renewable technologies, project development, and gives examples. Renewable energy can be combined with conventional energy sources to provide part or all of the energy demand at an installation. The appropriate technology mix for an installation will depend on site-specific factors such as renewable resources, energy costs, local energy policies and incentives, available land, mission compatibility, and other factors. The objective of this chapter is to provide basic background information and resources on renewable energy options for NATO leaders and energy personnel.

Electricity Generation Baseline Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Logan, Jeffrey; Marcy, Cara; McCall, James

This report was developed by a team of national laboratory analysts over the period October 2015 to May 2016 and is part of a series of studies that provide background material to inform development of the second installment of the Quadrennial Energy Review (QER 1.2). The report focuses specifically on U.S. power sector generation. The report limits itself to the generation sector and does not address in detail parallel issues in electricity end use, transmission and distribution, markets and policy design, and other important segments. The report lists 15 key findings about energy system needs of the future.

Future HIV Mentoring Programs to Enhance Diversity.

PubMed

Stoff, David M; Cargill, Victoria A

2016-09-01

This paper proposes a general template to guide future mentoring program development addressing: (i) considerations to ensure an adequate research workforce; (ii) key guidelines and principles of mentoring; and (iii) use of a logic model to develop program milestones, outcomes and evaluation. We focus on these areas to guide and inform the most effective mentoring program components, which we find to be more helpful than identifying specific features and ingredients. Although the focus is on the development of a new generation of investigators from diverse backgrounds, this template may also apply to mentoring programs for other investigators and for disciplines beyond HIV.

Workshop 8 (synthesis): challenges of expanding ecological sanitation into urban areas.

PubMed

Milburn, A; Matsui, S; Malmqvist, P A

2002-01-01

After seven papers discussing specific examples of ecological sanitation projects, the workshop considered the background, motivation and feasibility of this technology. It was agreed that ecological sanitation could help tackle water scarcity, health protection and, by recycling water and nutrients into agriculture, food scarcity. Dense cities are probably unsuitable for its implementation, but rural, town and peri-urban areas are promising. Key issues that remains are: the microbiological and chemical risks associated with the technology; the need for major information, education and support programmes; effective linking to reuse schemes; tailoring systems to meet local physical, socio-economic and cultural circumstances.

Manufacturing techniques for gyroscopes in gravity probe B

NASA Technical Reports Server (NTRS)

Rasquin, J. R.

1976-01-01

The design of the fused silica gyroscope configuration is presented. The first gyroscope was made for erection and spin tests only and does not contain the angle readout loops necessary for a functioning experimental gyroscope. The rotor ball described is not coated with the ultimate material, niobium, but instead with a sandwich of titanium, cooper, and titanium for spin-up test purposes. Background, historical information, manufacturing procedures, and sketches for this gyroscope are included to provide a better understanding of the device and the techniques and special tools required to manufacture a fused silica gyroscope to the required specifications.

Taiwan: Background Notes Series.

ERIC Educational Resources Information Center

Reams, Joanne Reppert

Concise background information on Taiwan is provided. The publication begins with a profile of Taiwan, discussing the people, geography, political establishment, and economy. A map of the country is provided. The bulk of the publication then provides more detailed information on Taiwan's people, geography, history, administration, political…

76 FR 51065 - Information Collection Request Under OMB Review

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-17

... (NAC) Questionnaire for Peace Corps Volunteer Background Investigation (OMB Control Number 0420-0001... Questionnaire for Peace Corps Volunteer Background Investigation (OMB Control Number 0420-0001) requests only... the proposed collection of information, including the validity of the methodology and assumptions used...

Examining the Beliefs and Practices of Four Effective Australian Primary Science Teachers

NASA Astrophysics Data System (ADS)

Fitzgerald, Angela; Dawson, Vaille; Hackling, Mark

2013-06-01

With trends across many countries still indicating the decline of student interest in school science and diminishing numbers of students studying science beyond the compulsory years, it seems that the field remains in crisis. To address these unfortunate trends, there needs to be a greater emphasis on science education research that highlights the good news stories. For example, what are science teachers actually doing in their classrooms to increase student interest and understanding in science? This article focuses on the science teaching beliefs and practices of four Western Australian primary school teachers. The teachers were nominated by a professional colleague as effective practitioners. The study involved gathering information from classroom observations and teacher interviews to provide background information to assist in developing understandings of these teachers and their science teaching. This article reports on the initial findings drawn from Deanne A, Kate B, Lisa C and Rebecca D. Their practices were organised into the following six categories: classroom environment; conceptual knowledge and procedural skills; teaching strategies and approaches; student-specific considerations; teacher-specific considerations; and context-specific considerations. In examining the components contributing to these categories, it was evident that the teachers' beliefs, as well as the contextual factors inherent in each classroom environment, influenced how and why they teach science in the ways they do.

RNase H-assisted RNA-primed rolling circle amplification for targeted RNA sequence detection.

PubMed

Takahashi, Hirokazu; Ohkawachi, Masahiko; Horio, Kyohei; Kobori, Toshiro; Aki, Tsunehiro; Matsumura, Yukihiko; Nakashimada, Yutaka; Okamura, Yoshiko

2018-05-17

RNA-primed rolling circle amplification (RPRCA) is a useful laboratory method for RNA detection; however, the detection of RNA is limited by the lack of information on 3'-terminal sequences. We uncovered that conventional RPRCA using pre-circularized probes could potentially detect the internal sequence of target RNA molecules in combination with RNase H. However, the specificity for mRNA detection was low, presumably due to non-specific hybridization of non-target RNA with the circular probe. To overcome this technical problem, we developed a method for detecting a sequence of interest in target RNA molecules via RNase H-assisted RPRCA using padlocked probes. When padlock probes are hybridized to the target RNA molecule, they are converted to the circular form by SplintR ligase. Subsequently, RNase H creates nick sites only in the hybridized RNA sequence, and single-stranded DNA is finally synthesized from the nick site by phi29 DNA polymerase. This method could specifically detect at least 10 fmol of the target RNA molecule without reverse transcription. Moreover, this method detected GFP mRNA present in 10 ng of total RNA isolated from Escherichia coli without background DNA amplification. Therefore, this method can potentially detect almost all types of RNA molecules without reverse transcription and reveal full-length sequence information.

Automating document classification for the Immune Epitope Database

PubMed Central

Wang, Peng; Morgan, Alexander A; Zhang, Qing; Sette, Alessandro; Peters, Bjoern

2007-01-01

Background The Immune Epitope Database contains information on immune epitopes curated manually from the scientific literature. Like similar projects in other knowledge domains, significant effort is spent on identifying which articles are relevant for this purpose. Results We here report our experience in automating this process using Naïve Bayes classifiers trained on 20,910 abstracts classified by domain experts. Improvements on the basic classifier performance were made by a) utilizing information stored in PubMed beyond the abstract itself b) applying standard feature selection criteria and c) extracting domain specific feature patterns that e.g. identify peptides sequences. We have implemented the classifier into the curation process determining if abstracts are clearly relevant, clearly irrelevant, or if no certain classification can be made, in which case the abstracts are manually classified. Testing this classification scheme on an independent dataset, we achieve 95% sensitivity and specificity in the 51.1% of abstracts that were automatically classified. Conclusion By implementing text classification, we have sped up the reference selection process without sacrificing sensitivity or specificity of the human expert classification. This study provides both practical recommendations for users of text classification tools, as well as a large dataset which can serve as a benchmark for tool developers. PMID:17655769

Improving the use of research evidence in guideline development: 12. Incorporating considerations of equity.

PubMed

Oxman, Andrew D; Schünemann, Holger J; Fretheim, Atle

2006-12-05

The World Health Organization (WHO), like many other organisations around the world, has recognised the need to use more rigorous processes to ensure that health care recommendations are informed by the best available research evidence. This is the 12th of a series of 16 reviews that have been prepared as background for advice from the WHO Advisory Committee on Health Research to WHO on how to achieve this. We reviewed the literature on incorporating considerations of equity in guidelines and recommendations. We searched PubMed and three databases of methodological studies for existing systematic reviews and relevant methodological research. We did not conduct systematic reviews ourselves. Our conclusions are based on the available evidence, consideration of what WHO and other organisations are doing and logical arguments. We found few directly relevant empirical methodological studies. These answers are based largely on logical arguments. When and how should inequities be addressed in systematic reviews that are used as background documents for recommendations? The following question should routinely be considered: Are there plausible reasons for anticipating differential relative effects across disadvantaged and advantaged populations? If there are plausible reasons for anticipating differential effects, additional evidence should be included in a review to inform judgments about the likelihood of differential effects. What questions about equity should routinely be addressed by those making recommendations on behalf of WHO? The following additional questions should routinely be considered: How likely is it that the results of available research are applicable to disadvantaged populations and settings? How likely are differences in baseline risk that would result in differential absolute effects across disadvantaged and advantaged populations? How likely is it that there are important differences in trade-offs between the expected benefits and harms across disadvantaged and advantaged populations? Are there different implications for disadvantaged and advantaged populations, or implications for addressing inequities? What context specific information is needed to inform adaptation and decision making in a specific setting with regard to impacts on equity? Those making recommendations on behalf of WHO should routinely consider and offer advice about the importance of the following types of context specific data that might be needed to inform adaptation and decision making in a specific setting: Effect modifiers for disadvantaged populations and for the likelihood of differential effects. Baseline risk in relationship to social and economic status. Utilization and access to care in relationship to social and economic status. Costs in relationship to social and economic status. Ethics and laws that may impact on strategies for addressing inequities. Availability of resources to address inequities. What implementation strategies are likely be needed to ensure that recommendations are implemented equitably? Organisational changes are likely to be important to address inequities. While it may only be possible to consider these in relationship to specific settings, consideration should be given to how best to provide support for identifying and addressing needs for organisational changes. In countries with pervasive inequities institutional, cultural and political changes may first be needed. Appropriate indicators of social and economic status should be used to monitor the effects of implementing recommendations on disadvantaged populations and on changes in social and economic status.

The Space From Heart Disease Intervention for People With Cardiovascular Disease and Distress: A Mixed-Methods Study

PubMed Central

Clifton, Abigail; Lee, Geraldine; Norman, Ian J; O'Callaghan, David; Tierney, Karen; Richards, Derek

2015-01-01

Background Poor self-management of symptoms and psychological distress leads to worse outcomes and excess health service use in cardiovascular disease (CVD). Online-delivered therapy is effective, but generic interventions lack relevance for people with specific long-term conditions, such as cardiovascular disease. Objective To develop a comprehensive online CVD-specific intervention to improve both self-management and well-being, and to test acceptability and feasibility. Methods Informed by the Medical Research Council (MRC) guidance for the development of complex interventions, we adapted an existing evidence-based generic intervention for depression and anxiety for people with CVD. Content was informed by a literature review of existing resources and trial evidence, and the findings of a focus group study. Think-aloud usability testing was conducted to identify improvements to design and content. Acceptability and feasibility were tested in a cross-sectional study. Results Focus group participants (n=10) agreed that no existing resource met all their needs. Improvements such as "collapse and expand" features were added based on findings that participants’ information needs varied, and specific information, such as detecting heart attacks and when to seek help, was added. Think-aloud testing (n=2) led to changes in font size and design changes around navigation. All participants of the cross-sectional study (10/10, 100%) were able to access and use the intervention. Reported satisfaction was good, although the intervention was perceived to lack relevance for people without comorbid psychological distress. Conclusions We have developed an evidence-based, theory-informed, user-led online intervention for improving self-management and well-being in CVD. The use of multiple evaluation tests informed improvements to content and usability. Preliminary acceptability and feasibility has been demonstrated. The Space from Heart Disease intervention is now ready to be tested for effectiveness. This work has also identified that people with CVD symptoms and comorbid distress would be the most appropriate sample for a future randomized controlled trial to evaluate its effectiveness. PMID:26133739

Robust Data Detection for the Photon-Counting Free-Space Optical System With Implicit CSI Acquisition and Background Radiation Compensation

NASA Astrophysics Data System (ADS)

Song, Tianyu; Kam, Pooi-Yuen

2016-02-01

Since atmospheric turbulence and pointing errors cause signal intensity fluctuations and the background radiation surrounding the free-space optical (FSO) receiver contributes an undesired noisy component, the receiver requires accurate channel state information (CSI) and background information to adjust the detection threshold. In most previous studies, for CSI acquisition, pilot symbols were employed, which leads to a reduction of spectral and energy efficiency; and an impractical assumption that the background radiation component is perfectly known was made. In this paper, we develop an efficient and robust sequence receiver, which acquires the CSI and the background information implicitly and requires no knowledge about the channel model information. It is robust since it can automatically estimate the CSI and background component and detect the data sequence accordingly. Its decision metric has a simple form and involves no integrals, and thus can be easily evaluated. A Viterbi-type trellis-search algorithm is adopted to improve the search efficiency, and a selective-store strategy is adopted to overcome a potential error floor problem as well as to increase the memory efficiency. To further simplify the receiver, a decision-feedback symbol-by-symbol receiver is proposed as an approximation of the sequence receiver. By simulations and theoretical analysis, we show that the performance of both the sequence receiver and the symbol-by-symbol receiver, approach that of detection with perfect knowledge of the CSI and background radiation, as the length of the window for forming the decision metric increases.

Classifying elephant behaviour through seismic vibrations.

PubMed

Mortimer, Beth; Rees, William Lake; Koelemeijer, Paula; Nissen-Meyer, Tarje

2018-05-07

Seismic waves - vibrations within and along the Earth's surface - are ubiquitous sources of information. During propagation, physical factors can obscure information transfer via vibrations and influence propagation range [1]. Here, we explore how terrain type and background seismic noise influence the propagation of seismic vibrations generated by African elephants. In Kenya, we recorded the ground-based vibrations of different wild elephant behaviours, such as locomotion and infrasonic vocalisations [2], as well as natural and anthropogenic seismic noise. We employed techniques from seismology to transform the geophone recordings into source functions - the time-varying seismic signature generated at the source. We used computer modelling to constrain the propagation ranges of elephant seismic vibrations for different terrains and noise levels. Behaviours that generate a high force on a sandy terrain with low noise propagate the furthest, over the kilometre scale. Our modelling also predicts that specific elephant behaviours can be distinguished and monitored over a range of propagation distances and noise levels. We conclude that seismic cues have considerable potential for both behavioural classification and remote monitoring of wildlife. In particular, classifying the seismic signatures of specific behaviours of large mammals remotely in real time, such as elephant running, could inform on poaching threats. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

Assessing the Acceptability and Usability of an Internet-Based Intelligent Health Assistant Developed for Use among Turkish Migrants: Results of a Study Conducted in Bremen, Germany

PubMed Central

Samkange-Zeeb, Florence; Ernst, Sinja Alexandra; Klein-Ellinghaus, Funda; Brand, Tilman; Reeske-Behrens, Anna; Plumbaum, Till; Zeeb, Hajo

2015-01-01

The Internet offers a new chance for health professionals to reach population groups not usually reached through traditional information channels, for example, migrants. Criticism has, however, been raised that most health information on the Internet is not easy to read and lacks cultural sensitivity. We developed an Internet-based bilingual health assistant especially for Turkish migrants in Germany, tested its acceptance, and evaluated its usability in a participatory research design with families with and without Turkish migrant background. The interactive health assistant covered the following: nutrition, physical activity, overweight, diabetes, as well as pregnancy and pregnancy support. The idea of an Internet-based health assistant was generally accepted by all participants of the evaluation study, as long as it would be incorporated in existing appliances, such as smartphones. The bilingual nature of the assistant was welcomed especially by first generation migrants, but migrant participants also indicated that not all health information needed to be made available in a culture-specific way. The participants were least satisfied with the nutrition component, which they felt should include recipes and ingredients from the culture of origin, as well as specific aspects of food preparation. PMID:26633455

Assessing the Acceptability and Usability of an Internet-Based Intelligent Health Assistant Developed for Use among Turkish Migrants: Results of a Study Conducted in Bremen, Germany.

PubMed

Samkange-Zeeb, Florence; Ernst, Sinja Alexandra; Klein-Ellinghaus, Funda; Brand, Tilman; Reeske-Behrens, Anna; Plumbaum, Till; Zeeb, Hajo

2015-12-03

The Internet offers a new chance for health professionals to reach population groups not usually reached through traditional information channels, for example, migrants. Criticism has, however, been raised that most health information on the Internet is not easy to read and lacks cultural sensitivity. We developed an Internet-based bilingual health assistant especially for Turkish migrants in Germany, tested its acceptance, and evaluated its usability in a participatory research design with families with and without Turkish migrant background. The interactive health assistant covered the following: nutrition, physical activity, overweight, diabetes, as well as pregnancy and pregnancy support. The idea of an Internet-based health assistant was generally accepted by all participants of the evaluation study, as long as it would be incorporated in existing appliances, such as smartphones. The bilingual nature of the assistant was welcomed especially by first generation migrants, but migrant participants also indicated that not all health information needed to be made available in a culture-specific way. The participants were least satisfied with the nutrition component, which they felt should include recipes and ingredients from the culture of origin, as well as specific aspects of food preparation.

Electric line source illumination of a chiral cylinder placed in another chiral background medium

NASA Astrophysics Data System (ADS)

Aslam, M.; Saleem, A.; Awan, Z. A.

2018-05-01

An electric line source illumination of a chiral cylinder embedded in a chiral background medium is considered. The field expressions inside and outside of a chiral cylinder have been derived using the wave field decomposition approach. The effects of various chiral cylinders, chiral background media and source locations upon the scattering gain pattern have been investigated. It is observed that the chiral background reduces the backward scattering gain as compared to the free space background for a dielectric cylinder. It is also studied that by moving a line source away from a cylinder reduces the backward scattering gain for a chiral cylinder placed in a chiral background under some specific conditions. A unique phenomenon of reduced scattering gain has been observed at a specific observation angle for a chiral cylinder placed in a chiral background having an electric line source location of unity free space wavelength. An isotropic scattering gain pattern is observed for a chiral nihility background provided that if cylinder is chiral or chiral nihility type. It is also observed that this isotropic behaviour is independent of background and cylinder chirality.

A gene-specific non-enhancer sequence is critical for expression from the promoter of the small heat shock protein gene αB-crystallin

PubMed Central

2014-01-01

Background Deciphering of the information content of eukaryotic promoters has remained confined to universal landmarks and conserved sequence elements such as enhancers and transcription factor binding motifs, which are considered sufficient for gene activation and regulation. Gene-specific sequences, interspersed between the canonical transacting factor binding sites or adjoining them within a promoter, are generally taken to be devoid of any regulatory information and have therefore been largely ignored. An unanswered question therefore is, do gene-specific sequences within a eukaryotic promoter have a role in gene activation? Here, we present an exhaustive experimental analysis of a gene-specific sequence adjoining the heat shock element (HSE) in the proximal promoter of the small heat shock protein gene, αB-crystallin (cryab). These sequences are highly conserved between the rodents and the humans. Results Using human retinal pigment epithelial cells in culture as the host, we have identified a 10-bp gene-specific promoter sequence (GPS), which, unlike an enhancer, controls expression from the promoter of this gene, only when in appropriate position and orientation. Notably, the data suggests that GPS in comparison with the HSE works in a context-independent fashion. Additionally, when moved upstream, about a nucleosome length of DNA (−154 bp) from the transcription start site (TSS), the activity of the promoter is markedly inhibited, suggesting its involvement in local promoter access. Importantly, we demonstrate that deletion of the GPS results in complete loss of cryab promoter activity in transgenic mice. Conclusions These data suggest that gene-specific sequences such as the GPS, identified here, may have critical roles in regulating gene-specific activity from eukaryotic promoters. PMID:24589182

Neighborhood Information Service Centers. Public Library "Information and Referral" Provides Significant New Personal Service to the Individual Library User. A Background Paper for the White House Conference on Library and Information Services.

ERIC Educational Resources Information Center

Layne, Elizabeth N.

This booklet, one of a series of background papers for the White House Conference, presents information and referral services as one of the ways libraries are developing programs to discharge their responsibilities to the public they serve. It details the determination of a woman librarian in Detroit to develop the first comprehensive I&R…

78 FR 5276 - Tribal Background Investigations and Licensing

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-25

... industry generally, including ownership interests in those businesses; (7) The name and address of any... temporary and permanent gaming licenses. DATES: Effective Date: February 25, 2013. FOR FURTHER INFORMATION.... Telephone: 202-632-7009. SUPPLEMENTARY INFORMATION: I. Background The Indian Gaming Regulatory Act (IGRA or...

28 CFR 25.4 - Record source categories.

Code of Federal Regulations, 2010 CFR

2010-07-01

....4 Judicial Administration DEPARTMENT OF JUSTICE DEPARTMENT OF JUSTICE INFORMATION SYSTEMS The National Instant Criminal Background Check System § 25.4 Record source categories. It is anticipated that... to the NICS Index. Information in the NCIC and III systems that will be searched during a background...

General Aviation in Nebraska: Nebraska SATS Project Background Paper No. 1

NASA Technical Reports Server (NTRS)

Smith, Russell; Wachal, Jocelyn

2000-01-01

The Nebraska SATS project is a state-level component of NASA's Small Aircraft Transportation System (SATS). During the next several years the project will examine several different factors affecting SATS implementation in Nebraska. These include economic and taxation issues, public policy issues, airport planning processes, information dissemination strategies, and systemic change factors. This background paper profiles the general aviation system in Nebraska. It is written to provide information about the "context" within which SATS will be pursued. The primary focus is thus on describing and providing background information about the current situation. A secondary focus is on drawing general conclusions about the ability of the current system to incorporate the types of changes implied by SATS. First, some brief information on the U.S. aviation system is provided. The next two sections profile the current general aviation aircraft and pilot base. Nebraska's system of general aviation airports is then described. Within this section of the paper, information is provided on the different types of general aviation airports in Nebraska, airport activity levels and current infrastructure. The fourth major section of the background paper looks at Nebraska's local airport authorities. These special purpose local governments oversee the majority of the general aviation airports in the state. Among the items examined are total expenditures, capital expenditures and planning activities. Next, the paper provides background information on the Nebraska Department of Aeronautics (NDA) and recent Federal funding for general aviation in Nebraska. The final section presents summary conclusions.

Assessing computer skills in Tanzanian medical students: an elective experience

PubMed Central

Samuel, Miriam; Coombes, John C; Miranda, J Jaime; Melvin, Rob; Young, Eoin JW; Azarmina, Pejman

2004-01-01

Background One estimate suggests that by 2010 more than 30% of a physician's time will be spent using information technology tools. The aim of this study is to assess the information and communication technologies (ICT) skills of medical students in Tanzania. We also report a pilot intervention of peer mentoring training in ICT by medical students from the UK tutoring students in Tanzania. Methods Design: Cross sectional study and pilot intervention study. Participants: Fourth year medical students (n = 92) attending Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania. Main outcome measures: Self-reported assessment of competence on ICT-related topics and ability to perform specific ICT tasks. Further information related to frequency of computer use (hours per week), years of computer use, reasons for use and access to computers. Skills at specific tasks were reassessed for 12 students following 4 to 6 hours of peer mentoring training. Results The highest levels of competence in generic ICT areas were for email, Internet and file management. For other skills such as word processing most respondents reported low levels of competence. The abilities to perform specific ICT skills were low – less than 60% of the participants were able to perform the core specific skills assessed. A period of approximately 5 hours of peer mentoring training produced an approximate doubling of competence scores for these skills. Conclusion Our study has found a low level of ability to use ICT facilities among medical students in a leading university in sub-Saharan Africa. A pilot scheme utilising UK elective students to tutor basic skills showed potential. Attention is required to develop interventions that can improve ICT skills, as well as computer access, in order to bridge the digital divide. PMID:15306029

The impact of different background errors in the assimilation of satellite radiances and in-situ observational data using WRFDA for three rainfall events over Iran

NASA Astrophysics Data System (ADS)

Zakeri, Zeinab; Azadi, Majid; Ghader, Sarmad

2018-01-01

Satellite radiances and in-situ observations are assimilated through Weather Research and Forecasting Data Assimilation (WRFDA) system into Advanced Research WRF (ARW) model over Iran and its neighboring area. Domain specific background error based on x and y components of wind speed (UV) control variables is calculated for WRFDA system and some sensitivity experiments are carried out to compare the impact of global background error and the domain specific background errors, both on the precipitation and 2-m temperature forecasts over Iran. Three precipitation events that occurred over the country during January, September and October 2014 are simulated in three different experiments and the results for precipitation and 2-m temperature are verified against the verifying surface observations. Results show that using domain specific background error improves 2-m temperature and 24-h accumulated precipitation forecasts consistently, while global background error may even degrade the forecasts compared to the experiments without data assimilation. The improvement in 2-m temperature is more evident during the first forecast hours and decreases significantly as the forecast length increases.

Stroke doctors: Who are we? A World Stroke Organization survey.

PubMed

Meretoja, Atte; Acciarresi, Monica; Akinyemi, Rufus O; Campbell, Bruce; Dowlatshahi, Dar; English, Coralie; Henninger, Nils; Poppe, Alexandre; Putaala, Jukka; Saini, Monica; Sato, Shoichiro; Wu, Bo; Brainin, Michael; Norrving, Bo; Davis, Stephen

2017-10-01

Background Specialist training provides skilled workforce for service delivery. Stroke medicine has evolved rapidly in the past years. No prior information exists on background or training of stroke doctors globally. Aims To describe the specialties that represent stroke doctors, their training requirements, and the scientific organizations ensuring continuous medical education. Methods The World Stroke Organization conducted an expert survey between June and November 2014 using e-mailed questionnaires. All Organization for Economic Co-operation and Development countries with >1 million population and other countries with >50 million population were included ( n = 49, total 5.6 billion inhabitants, 85% of global strokes). Two stroke experts from each selected country were surveyed, discrepancies resolved, and further information on identified stroke-specific curricula sought. Results We received responses from 48 (98%) countries. Of ischemic stroke patients, 64% were reportedly treated by neurologists, ranging from 5% in Ireland to 95% in the Netherlands. Per thousand annual strokes there were average six neurologists, ranging from 0.3 in Ethiopia to 33 in Israel. Of intracerebral hemorrhage patients, 29% were reportedly treated by neurosurgeons, ranging from 5% in Sweden to 79% in Japan, with three neurosurgeons per thousand strokes, ranging from 0.1 in Ethiopia to 24 in South Korea. Most countries had a stroke society (86%) while only 10 (21%) had a degree or subspecialty for stroke medicine. Conclusions Stroke doctor numbers, background specialties, and opportunities to specialize in stroke vary across the globe. Most countries have a scientific society to pursue advancement of stroke medicine, but few have stroke curricula.

Effect of display update interval, update type, and background on perception of aircraft separation on a cockpit display on traffic information

NASA Technical Reports Server (NTRS)

Jago, S.; Baty, D.; Oconnor, S.; Palmer, E.

1981-01-01

The concept of a cockpit display of traffic information (CDTI) includes the integration of air traffic, navigation, and other pertinent information in a single electronic display in the cockpit. Concise display symbology was developed for use in later full-mission simulator evaluations of the CDTI concept. Experimental variables used included the update interval motion of the aircraft, the update type, (that is, whether the two aircraft were updated at the same update interval or not), the background (grid pattern or no background), and encounter type (straight or curved). Only the type of encounter affected performance.

Development and testing of culturally sensitive patient information material for Turkish, Polish, Russian and Italian migrants with depression or chronic low back pain (KULTINFO): study protocol for a double-blind randomized controlled trial.

PubMed

Hölzel, Lars P; Ries, Zivile; Zill, Jördis M; Kriston, Levente; Dirmaier, Jörg; Härter, Martin; Bermejo, Isaac

2014-07-04

Many of the approximately 15 million people with a migration background living in Germany (19% of the population) are inadequately reached by existing healthcare provision. In the literature, the necessity for cultural adaptation of information material for patients with a migration background is often cited as a measure for improving healthcare.In this study, culturally sensitive information material will be developed and evaluated for patients with a migration background and depression or chronic low back pain. In this respect, it will be examined whether culturally sensitive information material is judged as more useful by the patients than standard translated patient information without cultural adaptation. The implementation and evaluation of culturally sensitive patient information material will occur in the framework of a double-blind randomized controlled parallel-group study in four study centres in Germany. Primary care patients with a Turkish, Polish, Russian or Italian migration background with a diagnosis of depressive disorder or chronic low back pain will be included and randomly allocated to the intervention group or the control group. In the intervention group, culturally sensitive patient information will be handed to the patient at the end of the physician consultation, while in the control group, standard translated patient information material will be provided. The patients will be surveyed by means of questionnaires following the consultation as well as after 8 weeks and 6 months. In addition to the primary outcome (subjective usefulness), several patient- and physician-rated secondary outcomes will be considered. The study will provide an empirical answer to the question of whether persons with a migration background perceive culturally sensitive patient information material as more useful than translated information material without cultural adaptation. Deutsches Register Klinischer Studien (DRKS-ID) DRKS00004241 and Universal Trial Number (UTN) U1111-1135-8043.

Why Do Patients and Caregivers Seek Answers From the Internet and Online Lung Specialists? A Qualitative Study

PubMed Central

Linssen, Cilia; Schramel, Franz MNH; Festen, Jan; Lammers, Ernst; Smit, Egbert F; Postmus, Pieter E; Westerman, Marjan J

2014-01-01

Background Since its launch in 2003, the Dutch Lung Cancer Information Center’s (DLIC) website has become increasingly popular. The most popular page of the website is the section “Ask the Physician”, where visitors can ask an online lung specialist questions anonymously and receive an answer quickly. Most questions were not only asked by lung cancer patients but also by their informal caregivers. Most questions concerned specific information about lung cancer. Objective Our goal was to explore the reasons why lung cancer patients and caregivers search the Internet for information and ask online lung specialists questions on the DLIC’s interactive page, “Ask the Physician”, rather than consulting with their own specialist. Methods This research consisted of a qualitative study with semistructured telephone interviews about medical information-seeking behavior (eg, information needs, reasons for querying online specialists). The sample comprised 5 lung cancer patients and 20 caregivers who posed a question on the interactive page of the DLIC website. Results Respondents used the Internet and the DLIC website to look for lung cancer–related information (general/specific to their personal situation) and to cope with cancer. They tried to achieve a better understanding of the information given by their own specialist and wanted to be prepared for the treatment trajectory and disease course. This mode of information supply helped them cope and gave them emotional support. The interactive webpage was also used as a second opinion. The absence of face-to-face contact made respondents feel freer to ask for any kind of information. By being able to pose a question instantly and receiving a relatively quick reply from the online specialist to urgent questions, respondents felt an easing of their anxiety as they did not have to wait until the next consultation with their own specialist. Conclusions The DLIC website with its interactive page is a valuable complementary mode of information supply and supportive care for lung cancer patients and caregivers. PMID:24496139

Robust pedestrian detection and tracking from a moving vehicle

NASA Astrophysics Data System (ADS)

Tuong, Nguyen Xuan; Müller, Thomas; Knoll, Alois

2011-01-01

In this paper, we address the problem of multi-person detection, tracking and distance estimation in a complex scenario using multi-cameras. Specifically, we are interested in a vision system for supporting the driver in avoiding any unwanted collision with the pedestrian. We propose an approach using Histograms of Oriented Gradients (HOG) to detect pedestrians on static images and a particle filter as a robust tracking technique to follow targets from frame to frame. Because the depth map requires expensive computation, we extract depth information of targets using Direct Linear Transformation (DLT) to reconstruct 3D-coordinates of correspondent points found by running Speeded Up Robust Features (SURF) on two input images. Using the particle filter the proposed tracker can efficiently handle target occlusions in a simple background environment. However, to achieve reliable performance in complex scenarios with frequent target occlusions and complex cluttered background, results from the detection module are integrated to create feedback and recover the tracker from tracking failures due to the complexity of the environment and target appearance model variability. The proposed approach is evaluated on different data sets both in a simple background scenario and a cluttered background environment. The result shows that, by integrating detector and tracker, a reliable and stable performance is possible even if occlusion occurs frequently in highly complex environment. A vision-based collision avoidance system for an intelligent car, as a result, can be achieved.

Noise Reduction with Microphone Arrays for Speaker Identification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cohen, Z

Reducing acoustic noise in audio recordings is an ongoing problem that plagues many applications. This noise is hard to reduce because of interfering sources and non-stationary behavior of the overall background noise. Many single channel noise reduction algorithms exist but are limited in that the more the noise is reduced; the more the signal of interest is distorted due to the fact that the signal and noise overlap in frequency. Specifically acoustic background noise causes problems in the area of speaker identification. Recording a speaker in the presence of acoustic noise ultimately limits the performance and confidence of speaker identificationmore » algorithms. In situations where it is impossible to control the environment where the speech sample is taken, noise reduction filtering algorithms need to be developed to clean the recorded speech of background noise. Because single channel noise reduction algorithms would distort the speech signal, the overall challenge of this project was to see if spatial information provided by microphone arrays could be exploited to aid in speaker identification. The goals are: (1) Test the feasibility of using microphone arrays to reduce background noise in speech recordings; (2) Characterize and compare different multichannel noise reduction algorithms; (3) Provide recommendations for using these multichannel algorithms; and (4) Ultimately answer the question - Can the use of microphone arrays aid in speaker identification?« less

Toward theoretical understanding of the fertility preservation decision-making process: Examining information processing among young women with cancer

PubMed Central

Hershberger, Patricia E.; Finnegan, Lorna; Altfeld, Susan; Lake, Sara; Hirshfeld-Cytron, Jennifer

2014-01-01

Background Young women with cancer now face the complex decision about whether to undergo fertility preservation. Yet little is known about how these women process information involved in making this decision. Objective The purpose of this paper is to expand theoretical understanding of the decision-making process by examining aspects of information processing among young women diagnosed with cancer. Methods Using a grounded theory approach, 27 women with cancer participated in individual, semi-structured interviews. Data were coded and analyzed using constant-comparison techniques that were guided by five dimensions within the Contemplate phase of the decision-making process framework. Results In the first dimension, young women acquired information primarily from clinicians and Internet sources. Experiential information, often obtained from peers, occurred in the second dimension. Preferences and values were constructed in the third dimension as women acquired factual, moral, and ethical information. Women desired tailored, personalized information that was specific to their situation in the fourth dimension; however, women struggled with communicating these needs to clinicians. In the fifth dimension, women offered detailed descriptions of clinician behaviors that enhance or impede decisional debriefing. Conclusion Better understanding of theoretical underpinnings surrounding women’s information processes can facilitate decision support and improve clinical care. PMID:24552086

Generation and memory for contextual detail.

PubMed

Mulligan, Neil W

2004-07-01

Generation enhances item memory but may not enhance other aspects of memory. In 12 experiments, the author investigated the effect of generation on context memory, motivated in part by the hypothesis that generation produces a trade-off in encoding item and contextual information. Participants generated some study words (e.g., hot-c__) and read others (e.g., hot-cold). Generation consistently enhanced item memory but did not enhance context memory. More specifically, generation disrupted context memory for the color of the target word but did not affect context memory for location, background color, and cue-word color. The specificity of the negative generation effect in context memory argues against a general item-context trade-off. A processing account of generation meets greater success. In addition, the results provide no evidence that generation enhances recollection of contextual details. Copyright 2004 APA, all rights reserved

Development of a comprehensive list of criteria for evaluating consumer education materials on colorectal cancer screening

PubMed Central

2013-01-01

Background Appropriate patient information materials may support the consumer’s decision to attend or not to attend colorectal cancer (CRC) screening tests (fecal occult blood test and screening colonoscopy). The aim of this study was to develop a list of criteria to assess whether written health information materials on CRC screening provide balanced, unbiased, quantified, understandable, and evidence-based health information (EBHI) about CRC and CRC screening. Methods The list of criteria was developed based on recommendations and assessment tools for health information in the following steps: (1) Systematic literature search in 13 electronic databases (search period: 2000–2010) and completed by an Internet search (2) Extraction of identified criteria (3) Grouping of criteria into categories and domains (4) Compilation of a manual of adequate answers derived from systematic reviews and S3 guidelines (5) Review by external experts (6) Modification (7) Final discussion with external experts. Results Thirty-one publications on health information tools and recommendations were identified. The final list of criteria includes a total of 230 single criteria in three generic domains (formal issues, presentation and understandability, and neutrality and balance) and one CRC-specific domain. A multi-dimensional rating approach was used whenever appropriate (e.g., rating for the presence, correctness, presentation and level of evidence of information). Free text input was allowed to ensure the transparency of assessment. The answer manual proved to be essential to the rating process. Quantitative analyses can be made depending on the level and dimensions of criteria. Conclusions This comprehensive list of criteria clearly has a wider range of evaluation than previous assessment tools. It is not intended as a final quality assessment tool, but as a first step toward thorough evaluation of specific information materials for their adherence to EBHI requirements. This criteria list may also be used to revise leaflets and to develop evidence-based health information on CRC screening. After adjustment for different procedure-specific criteria, the list of criteria can also be applied to other cancer screening procedures. PMID:24028691

Asymmetric nanofluidic grating detector for differential refractive index measurement and biosensing.

PubMed

Purr, F; Bassu, M; Lowe, R D; Thürmann, B; Dietzel, A; Burg, T P

2017-12-05

Measuring small changes in refractive index can provide both sensitive and contactless information on molecule concentration or process conditions for a wide range of applications. However, refractive index measurements are easily perturbed by non-specific background signals, such as temperature changes or non-specific binding. Here, we present an optofluidic device for measuring refractive index with direct background subtraction within a single measurement. The device is comprised of two interdigitated arrays of nanofluidic channels designed to form an optical grating. Optical path differences between the two sets of channels can be measured directly via an intensity ratio within the diffraction pattern that forms when the grating is illuminated by a collimated laser beam. Our results show that no calibration or biasing is required if the unit cell of the grating is designed with an appropriate built-in asymmetry. In proof-of-concept experiments we attained a noise level equivalent to ∼10 -5 refractive index units (30 Hz sampling rate, 4 min measurement interval). Furthermore, we show that the accumulation of biomolecules on the surface of the nanochannels can be measured in real-time. Because of its simplicity and robustness, we expect that this inherently differential measurement concept will find many applications in ultra-low volume analytical systems, biosensors, and portable devices.

CHAD USER’S GUIDE: Extracting Human Activity Information from CHAD on the PC

EPA Science Inventory

The Consolidated Human Activity Database (CHAD) User Guide offers a short tutorial about CHAD Access; background on the CHAD Databases; background on individual studies in CHAD; and information about using CHAD data, caveats, known problems, notes, and database design and develop...

Comparison of the Source and Quality of Information on the Internet Between Anterolateral Ligament Reconstruction and Anterior Cruciate Ligament Reconstruction: An Australian Experience

PubMed Central

Devitt, Brian M.; Hartwig, Taylor; Klemm, Haydn; Cosic, Filip T.; Green, James; Webster, Kate E.; Feller, Julian A.; Baker, Joseph F.

2017-01-01

Background: The internet is a valuable tool, but concerns exist regarding the quality and accuracy of medical information available online. Purpose: To evaluate the source and quality of information on the internet relating to anterolateral ligament reconstruction (ALLR) compared with anterior cruciate ligament reconstruction (ACLR). Study Design: Cross-sectional study. Methods: A questionnaire was administered to 50 ACLR patients in Australia to determine their use of the internet to research their operation and their familiarity with the anterolateral ligament (ALL) of the knee. The most common search terms were determined, and the first 70 websites returned by the 5 most popular search engines were used to assess the quality of information about ACLR and ALLR. Each site was categorized by type and was assessed for quality and validity using the DISCERN score, the Journal of the American Medical Association (JAMA) benchmark criteria, and a novel specific content score for each procedure. The presence of the Health on the Net Code (HONcode) seal was also recorded. Results: The majority (84%) of ACLR patients used the internet to research their operation. The quality of information available for ALLR was significantly inferior to that for ACLR according to the DISCERN score (37.3 ± 3.4 vs 54.4 ± 4.6; P < .0001) and specific content score (5.3 ± 1.3 vs 11.0 ± 1.5; P < .0001). ACLR websites were predominantly physician produced, while the majority of ALLR websites were academic. In contrast to ACLR websites, the majority of ALLR websites did not provide information on the indication for treatment or potential complications. ALLR websites scored better on the JAMA benchmark criteria due to the predominance of academic websites. A greater proportion of ACLR websites (14.6%) versus ALLR websites (2.5%) provided an HONcode seal. Correlation was demonstrated between the DISCERN score and specific content scores for both ACLR and ALLR but not with JAMA benchmark criteria. The specific content score had high reliability for both ACLR and ALLR. Conclusion: The majority of patients undergoing ACLR in Australia used the internet to research the procedure. The quality of information on the internet relating to ALLR was significantly inferior to information about ACLR. Most ALLR websites failed to include crucial information about the indication or options for treatment, prognosis, and potential complications. Surgeons should be aware of the information to which their patients are exposed through the internet and should be proactive in directing patients to appropriate websites. PMID:29242806

Enriching semantic knowledge bases for opinion mining in big data applications.

PubMed

Weichselbraun, A; Gindl, S; Scharl, A

2014-10-01

This paper presents a novel method for contextualizing and enriching large semantic knowledge bases for opinion mining with a focus on Web intelligence platforms and other high-throughput big data applications. The method is not only applicable to traditional sentiment lexicons, but also to more comprehensive, multi-dimensional affective resources such as SenticNet. It comprises the following steps: (i) identify ambiguous sentiment terms, (ii) provide context information extracted from a domain-specific training corpus, and (iii) ground this contextual information to structured background knowledge sources such as ConceptNet and WordNet. A quantitative evaluation shows a significant improvement when using an enriched version of SenticNet for polarity classification. Crowdsourced gold standard data in conjunction with a qualitative evaluation sheds light on the strengths and weaknesses of the concept grounding, and on the quality of the enrichment process.

Assessment of fragment projection hazard: probability distributions for the initial direction of fragments.

PubMed

Tugnoli, Alessandro; Gubinelli, Gianfilippo; Landucci, Gabriele; Cozzani, Valerio

2014-08-30

The evaluation of the initial direction and velocity of the fragments generated in the fragmentation of a vessel due to internal pressure is an important information in the assessment of damage caused by fragments, in particular within the quantitative risk assessment (QRA) of chemical and process plants. In the present study an approach is proposed to the identification and validation of probability density functions (pdfs) for the initial direction of the fragments. A detailed review of a large number of past accidents provided the background information for the validation procedure. A specific method was developed for the validation of the proposed pdfs. Validated pdfs were obtained for both the vertical and horizontal angles of projection and for the initial velocity of the fragments. Copyright © 2014 Elsevier B.V. All rights reserved.

The effect of self-regulatory and metacognitive strategy instruction on impoverished students' assessment achievement in physics

NASA Astrophysics Data System (ADS)

Fouche, Jaunine

The purpose of this nonequivalent control group design study was to evaluate the effectiveness of metacognitive and self-regulatory strategy use on the assessment achievement of 215 9th-grade, residential physics students from low socioeconomic status (low-SES) backgrounds. Students from low-SES backgrounds often lack the self-regulatory habits and metacognitive strategies to improve academic performance. In an effort to increase these scores and to increase student self-regulation and metacognition with regard to achievement in physics, this study investigated the use of metacognitive and self-regulatory strategies specifically as they apply to students' use of their own assessment data. Traditionally, student performance data is used by adults to inform instructional and curricular decisions. However, students are rarely given or asked to evaluate their own performance data. Moreover, students are not shown how to use this data to plan for or inform their own learning. It was found that students in the overall and algebra-ready treatment groups performed significantly better than their control group peers. These results are favorable for inclusion of strategies involving self-regulation and metacognition in secondary physics classrooms. Although these results may be applicable across residential, impoverished populations, further research is needed with non-residential populations.

Progress towards millennium development goal 1 in northern rural Nicaragua: Findings from a health and demographic surveillance site

PubMed Central

2012-01-01

Background Millennium Development Goal 1 encourages local initiatives for the eradication of extreme poverty. However, monitoring is indispensable to insure that actions performed at higher policy levels attain success. Poverty in rural areas in low- and middle-income countries remains chronic. Nevertheless, a rural area (Cuatro Santos) in northern Nicaragua has made substantial progress toward poverty eradication by 2015. We examined the level of poverty there and described interventions aimed at reducing it. Methods Household data collected from a Health and Demographic Surveillance System was used to analyze poverty and the transition out of it, as well as background information on family members. In the follow-up, information about specific interventions (i.e., installation of piped drinking water, latrines, access to microcredit, home gardening, and technical education) linked them to the demographic data. A propensity score was used to measure the association between the interventions and the resulting transition from poverty. Results Between 2004 and 2009, poverty was reduced as a number of interventions increased. Although microcredit was inequitably distributed across the population, combined with home gardening and technical training, it resulted in significant poverty reduction in this rural area. Conclusions Sustainable interventions reduced poverty in the rural areas studied by about one- third. PMID:22894144

The German Young Olympic Athletes' Lifestyle and Health Management Study (GOAL Study): design of a mixed-method study

PubMed Central

2011-01-01

Background In order to perform at top levels, elite athletes have to both protect and risk their health at the same time. Adolescent elite athletes have the additional challenge of coping with substantial physical, psychological and social transformations. The contradictory phenomenon of protecting and risking the adolescent athletes' health in sports challenges the development of health promotion and protection strategies. The GOAL Study (German Young Olympic Athletes' Lifestyle and Health Management Study) analyzes the individual and organizational management of health in adolescent elite sports. Methods/design We combine quantitative and qualitative approaches in a mixed-method study. This allows us to gather a broad range of representative information on squad athletes from all Olympic disciplines as well as in-depth information on four selected Olympic disciplines (artistic gymnastics, biathlon, handball and wrestling). Within the quantitative section we attempt to identify the young athletes' health and nutrition behavior, their subjective health state and their lay health representations, health-related social networks, and structures of medical attendance. 1138 national team level athletes born between 1992 and 1995 from 51 Olympic disciplines responded to the questionnaire (response rate: 61,75%). The qualitative section investigates the meaning and relevance of health and nutrition within the athletes' sports specific surroundings, the impact of biographic backgrounds on individual health behavior, and sports specific cultures of health, nutrition and risk. We interviewed 24 athletes and 28 coaching and medical experts, and carried out 14 multi-day participant observations at training sessions and competitions. Conclusions The studies' results will serve as the basis for developing tailored health promotion strategies to be in cooperation with German elite sports associations. PMID:21627777

Analytical Calculation of Mutual Information between Weakly Coupled Poisson-Spiking Neurons in Models of Dynamically Gated Communication.

PubMed

Cannon, Jonathan

2017-01-01

Mutual information is a commonly used measure of communication between neurons, but little theory exists describing the relationship between mutual information and the parameters of the underlying neuronal interaction. Such a theory could help us understand how specific physiological changes affect the capacity of neurons to synaptically communicate, and, in particular, they could help us characterize the mechanisms by which neuronal dynamics gate the flow of information in the brain. Here we study a pair of linear-nonlinear-Poisson neurons coupled by a weak synapse. We derive an analytical expression describing the mutual information between their spike trains in terms of synapse strength, neuronal activation function, the time course of postsynaptic currents, and the time course of the background input received by the two neurons. This expression allows mutual information calculations that would otherwise be computationally intractable. We use this expression to analytically explore the interaction of excitation, information transmission, and the convexity of the activation function. Then, using this expression to quantify mutual information in simulations, we illustrate the information-gating effects of neural oscillations and oscillatory coherence, which may either increase or decrease the mutual information across the synapse depending on parameters. Finally, we show analytically that our results can quantitatively describe the selection of one information pathway over another when multiple sending neurons project weakly to a single receiving neuron.

Foreign Policy Choices for Americans: A Nonpartisan Guide for Voters.

ERIC Educational Resources Information Center

Hoepli, Nancy L., Ed.; And Others

Eighteen foreign policy topics are presented in this book to provide voters, officeholders, candidates, students, and teachers with background information, facts, and U.S. foreign policies. A fact list, historical background information, current administration policy, and policy alternatives are described for most of these topics. Part 1 discusses…

Martin Luther King, Jr. Teacher's Resource Manual.

ERIC Educational Resources Information Center

Connecticut State Dept. of Education, Hartford.

This Connecticut teachers' manual on Martin Luther King, Jr. includes: (1) teacher background information; (2) five excerpts from King's speeches; (3) four themes for lesson plans; and (4) sample lesson plans. The teacher's background information provides biographical sketches of King and his precursors. The five speeches reproduced here are…

Employment and Training Legislation-1968; Background Information.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. Senate Committee on Labor and Public Welfare.

This volume supplied background information for employment and training legislation for the Committee on Labor and Public Welfare of the United States Senate for 1968. It includes: (1) excerpts from reports and recommendations of national committees and commissions on civil disorders, rural poverty, technology and automation, food and fiber, and…

Teaching Students about Their Civic Obligation--Jury Duty.

ERIC Educational Resources Information Center

Engelhardt, Leah T.; Steinbrink, John E.

2001-01-01

Contends that early adolescents need to learn how the jury trial system works. Provides background information on the topic for teachers. Includes a two-day lesson plan on jury duty as a civic obligation, background information for students, and extension activities relating to jury trials in the appendix. (CMK)

Opening Pandora's Stream: Piping Music into the Information Literacy Classroom

ERIC Educational Resources Information Center

Langan, Kathleen A.; Sachs, Dianna E.

2013-01-01

Although it is well known that music can affect cognitive processes, little research has been conducted examining the influence of background music on students in information literacy classrooms. In 2010, librarians at Western Michigan University investigated the effect of background music on student engagement and retention of information…

Mexico: The Quest for a U.S. Policy.

ERIC Educational Resources Information Center

Smith, Peter H.

Illustrated with photographs, cartoons and charts, this essay provides background information on the Mexican political system and economy and discusses the main issues confronting the United States in its relations with Mexico. The essay was written to provide interested citizens with background information on important foreign policy questions.…

Acid Rain Materials for Classroom Use.

ERIC Educational Resources Information Center

Factor, Lance; Kooser, Robert G.

This booklet contains three separate papers suitable for use in an advanced high school or college chemistry course. The first paper provides background information on acids and bases. The second paper provides additional background information, focusing on certain aspects of atmospheric chemistry as it relates to the acid rain problem. An attempt…

78 FR 23545 - Proposed Extension of Approval of Information Collection; Comment Request: Third Party Conformity...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-19

... evaluate whether third party conformity assessment bodies meet the requirements to test for compliance to... background documents or comments received, go to http://www.regulations.gov . FOR FURTHER INFORMATION CONTACT...: A. Background The Consumer Product Safety Improvement Act of 2008 (CPSIA) requires third party...

77 FR 15456 - Agency Information Collection Activities: Proposed Information Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-15

... charge regarding the employment history of, and the publicly adjudicated disciplinary and enforcement... for a State and national criminal background check; and (2) personal history and experience, including... criminal history background reports and actions taken with respect thereto. Type of Review: Extension of a...

A framework for ecological decision support systems: Building the right systems and building the systems right

USGS Publications Warehouse

D'Erchia, Frank; Korschgen, Carl E.; Nyquist, M.; Root, Ralph; Sojda, Richard S.; Stine, Peter

2001-01-01

Workshops in the late 1990's launched the commitment of the U.S. Geological Survey's Biological Resources Division (BRD) to develop and implement decision support systems (DSS) applications. One of the primary goals of this framework document is to provide sufficient background and information for Department of the Interior (DOI) bureau stakeholders and other clients to determine the potential for DSS development. Such an understanding can assist them in carrying out effective land planning and management practices. This document provides a definition of DSS and its characteristics and capabilities. It proceeds to describe issues related to meeting resource managers needs, such as the needs for specific applications, customer requirements, information and technology transfer, user support, and institutionalization. Using the decision process as a means to guide DSS development and determine users needs is also discussed. We conclude with information on method to evaluate DSS development efforts and recommended procedures for verification and validation. 

Information based universal feature extraction

NASA Astrophysics Data System (ADS)

Amiri, Mohammad; Brause, Rüdiger

2015-02-01

In many real world image based pattern recognition tasks, the extraction and usage of task-relevant features are the most crucial part of the diagnosis. In the standard approach, they mostly remain task-specific, although humans who perform such a task always use the same image features, trained in early childhood. It seems that universal feature sets exist, but they are not yet systematically found. In our contribution, we tried to find those universal image feature sets that are valuable for most image related tasks. In our approach, we trained a neural network by natural and non-natural images of objects and background, using a Shannon information-based algorithm and learning constraints. The goal was to extract those features that give the most valuable information for classification of visual objects hand-written digits. This will give a good start and performance increase for all other image learning tasks, implementing a transfer learning approach. As result, in our case we found that we could indeed extract features which are valid in all three kinds of tasks.

K-12 education sector desk reference. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-01-01

K-12 schools are a major energy customer. To help utility managers better analyze their business relationships with this important market segment, this reference provides background information, statistics, and other useful information. This is a reference. It is a compilation of figures, charts, and tables taken from many existing sources representing some of the best information available about K-12 schools. Analysts reviews over 2,500 pages of government and private sector documents (listed in Appendix A) to select the 100 pages included here. They made every effort to select documents likely to be useful to utility planning staff and program managers. Wherevermore » possible, specific state data have been included to help utility staff compute impacts within a service territory. Both a phone number and e-mail address have been included wherever available for each document listed in Appendix A. The report includes data on the following: energy use; federal mandates; deferred maintenance; indoor air quality; and technology in education. 21 figs., 49 tabs.« less

SOLID WASTE INTEGRATED FORECAST TECHNICAL (SWIFT) REPORT FY2005 THRU FY2035 2005.0 VOLUME 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

BARCOT, R.A.

This report provides up-to-date life cycle information about the radioactive solid waste expected to be managed by Hanford's Waste Management (WM) Project from onsite and offsite generators. It includes: (1) an overview of Hanford-wide solid waste to be managed by the WM Project; (2) multi-level and waste class-specific estimates; (3) background information on waste sources; and (4) comparisons to previous forecasts and other national data sources. The focus of this report is low-level waste (LLW), mixed low-level waste (MLLW), and transuranic waste, both non-mixed and mixed (TRU(M)). Some details on hazardous waste are also provided, however, this information is notmore » considered comprehensive. This report includes data requested in December, 2004 with updates through March 31,2005. The data represent a life cycle forecast covering all reported activities from FY2005 through the end of each program's life cycle and are an update of the previous FY2004.1 data version.« less

Informed Decision Making About Prostate Cancer Testing in Predominantly Immigrant Black Men: A Randomized Controlled Trial

PubMed Central

Lepore, Stephen J.; Wolf, Randi L.; Basch, Charles E.; Godfrey, Melissa; McGinty, Emma; Shmukler, Celia; Ullman, Ralph; Thomas, Nigel; Weinrich, Sally

2012-01-01

Background Decision support interventions have been developed to help men clarify their values and make informed decisions about prostate cancer testing, but they seldom target high-risk black and immigrant men. Purpose This study evaluated the efficacy of a decision support intervention focused on prostate cancer testing in a sample of predominantly immigrant black men. Methods Black men (N = 490) were randomized to tailored telephone education about prostate cancer testing or a control condition. Results Post-intervention, the intervention group had significantly greater knowledge, lower decision conflict, and greater likelihood of talking with their physician about prostate cancer testing than the control group. There were no significant intervention effects on prostate specific antigen testing, congruence between testing intention and behavior, or anxiety. Conclusions A tailored telephone decision support intervention can promote informed decision making about prostate cancer testing in black and predominantly immigrant men without increasing testing or anxiety. Clinical trial Registered in clinicaltrials.gov (NCT01415375) PMID:22825933

Development of cytochromes P450 in avian species as a biomarker for environmental contaminant exposure and effect: Procedures and baseline values

USGS Publications Warehouse

Melancon, M.J.; Bengston, David A.; Henshel, Diane S.

1996-01-01

As in mammals and fish, birds respond to many environmental contaminants with induction of hepatic cytochromes P450. In order to monitor cytchromes P450 in specific avian species, for assessing the status of that species or the habitat it utilizes, it is necessary to have background information on the appropriate assay conditions and the responsiveness of cytochrome P450 induction in that species. Assay of four monooxygenases which give resorufin as product using a fluorescence microwell plate scanner has proven to be an effective approach. Information is provided on the incubation conditions and baseline activity for twenty avian species at ages ranging from pipping embryo to adult. Induction responsiveness is presented for sixteen of them. This information can serve as a guide for those who wish to utilize cytochrome P450 as a biomarker for contaminant exposure and effect to aid in selection of appropriate species, age, and monooxygenase assay(s).

Lunar cartographic dossier, volume 1

NASA Technical Reports Server (NTRS)

Schimerman, L. A. (Editor)

1975-01-01

The dossier is designed to provide an up to date summary of the extent and quality of cartographic information as well as describing materials available to support lunar scientific investigation and study. It covers the specific photographic, selenodetic and cartographic data considered to be of continuing significance to users of lunar cartographic information. Historical background data is included. Descriptive and evaluative information is presented concerning lunar maps, photomaps and photo mosaics. Discussion comprises identification of series or individual sheet characteristics, control basis, source materials and compilation methodology used. The global, regional and local selenodetic control are described which were produced for lunar feature location in support of lunar mapping or positional study. Further discussion covers the fundamental basis for each control system, number of points produced, techniques employed and evaluated accuracy. Although lunar photography is an informational source rather than a cartographic product, a photography section was included to facilitate correlation to the mapping and control works described. Description of lunar photographic systems, photography and photo support data are presented from a cartographic-photogrammetric viewpoint with commentary on cartographic applications.

Advance Directives as Support of Autonomy for Persons with Dementia? A Pilot Study among Persons with Dementia and Their Informal Caregivers

PubMed Central

Schmidhuber, Martina; Haeupler, Sandra; Marinova-Schmidt, Velislava; Frewer, Andreas; Kolominsky-Rabas, Peter L.

2017-01-01

Background Advance directives could be an important instrument to support a person's will once he/she is not able to consent anymore – if composed competently. A survey was conducted to identify the level of knowledge concerning possibilities and limits of advance directives. Methods The study was conducted as part of the Bavarian Dementia Survey (BayDem). Data were collected from January 2014 to December 2015 by structured face-to-face interviews. Study participants were persons with dementia and their informal caregivers (n = 74). Results In total, 66% reported having written an advance directive. Concerning the participants' knowledge about possibilities and limitations of advance directives, a lack of knowledge was noted about the possibility to revoke an advance directive. Furthermore, 70% of informal caregivers and 56% of persons with dementia were not aware of the possibility to include dementia-specific terms in the advance directive. Conclusion It is necessary to optimize structures for public information and education concerning the topic of advance directives for persons with dementia. PMID:29118785

C3: The Compositional Construction of Context. A New, More Effective and Efficient Way to Marshal Inferences from Background Knowledge

DTIC Science & Technology

2014-09-01

quarter. Deep natural language understanding , efficient inference, pragmatics, background knowledge U U U SAR 4 Dr. David McDonald (781) 718-1964 C3...effective and efficient way to marshal inferences from background knowledge ’ N00014-13-1-0228 Dr. David McDonald Smart Information Flow Technologies, dba...for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data

Overview of an REU program: A case study in gender parity, ethnic diversity, and community college students

NASA Astrophysics Data System (ADS)

Pearson, J. K.; Noriega, G.; Benthien, M. L.

2017-12-01

The Undergraduate Studies in Earthquake Information Technology (USEIT) is an REU Internship Program focused in multi-disciplinary, collaborative research offered through the Southern California Earthquake Center (SCEC); a research consortium focused on earthquake science. USEIT is an 8-week intensive undergraduate research program. The program is designed for interns to work as a collaborative engine to solve an overarching real-world earthquake problem referred to as the "Grand Challenge". The interns are organized in teams and paired with mentors that have expertise in their specific task in the Grand Challenge. The program is focused around earthquake system science, where students have the opportunity to use super computers, programming platforms, geographic information systems, and internally designed and developed visualization software. The goal of the USEIT program is to motivate undergraduates from diverse backgrounds towards careers in science and engineering through team-based research in the field of earthquake information technology. Efforts are made to recruit students with diverse backgrounds, taking into consideration gender, ethnic background, socioeconomic standing, major, college year, and institution type (2-year and 4-year colleges). USEIT has a partnership with two local community colleges to recruit underserved students. Our emphasis is to attract students that would 1) grow and develop technical skills, soft skills, and confidence from the program, and 2) provide perspective and innovation to the program. USEIT offers on-campus housing to provide a submerged learning environment, recruits diverse majors to foster interdisciplinary collaboration, maintains a full time in lab mentor for day-to-day intern needs, takes students on field trips to provide context to their research, and plans activities and field trips for team building and morale. Each year metrics are collected through exit surveys, personal statements, and intern experience statements. We highlight lessons learned, including a need for pre-program engagement to ensure student success.

Using Intervention Mapping to develop a programme to prevent sexually transmittable infections, including HIV, among heterosexual migrant men

PubMed Central

Wolfers, Mireille EG; van den Hoek, Caty; Brug, Johannes; de Zwart, Onno

2007-01-01

Background There is little experience with carefully developed interventions in the HIV/STI prevention field aimed at adult heterosexual target groups in the Netherlands. The ability to apply intervention development protocols, like Intervention Mapping, in daily practice outside of academia, is a matter of concern. An urgent need also exists for interventions aimed at the prevention of STI in migrant populations in the Netherlands. This article describes the theory and evidence based development of HIV/STI prevention interventions by the Municipal Public Health Service Rotterdam Area (MPHS), the Netherlands, for heterosexual migrant men with Surinamese, Dutch-Caribbean, Cape Verdean, Turkish and Moroccan backgrounds. Methods First a needs assessment was carried out. Then, a literature review was done, key figures were interviewed and seven group discussions were held. Subsequently, the results were translated into specific objectives ("change objectives") and used in intervention development for two subgroups: men with an Afro-Caribbean background and unmarried men with a Turkish and Moroccan background. A matrix of change objectives was made for each subgroup and suitable theoretical methods and practical strategies were selected. Culturally-tailored interventions were designed and were pre-tested among the target groups. Results This development process resulted in two interventions for specific subgroups that were appreciated by both the target groups and the migrant prevention workers. The project took place in collaboration with a university center, which provided an opportunity to get expert advice at every step of the Intervention Mapping process. At relevant points of the development process, migrant health educators and target group members provided advice and feedback on the draft intervention materials. Conclusion This intervention development project indicates that careful well-informed intervention development using Intervention Mapping is feasible in the daily practice of the MPHS, provided that sufficient time and expertise on this approach is available. Further research should test the effectiveness of these interventions. PMID:17615052

Hospital clinical pharmacy services in Vietnam.

PubMed

Trinh, Hieu T; Nguyen, Huong T L; Pham, Van T T; Ba, Hai L; Dong, Phuong T X; Cao, Thao T B; Nguyen, Hanh T H; Brien, Jo-Anne

2018-04-07

Background Clinical pharmacy is key to the quality use of medicines. While there are different approaches in different countries, international perspectives may inform health service development. The Vietnamese Ministry of Health introduced a legal regulation of clinical pharmacy services in December 2012. Objective To describe the services, and to explore reported barriers and facilitators in implementing clinical pharmacy activities in Vietnamese hospitals after the introduction of Vietnamese Ministry of Health legal regulation. Setting Thirty-nine hospitals in Hanoi, Vietnam, including 22 provincial and 17 district hospitals. Method A mixed methods study was utilized. An online questionnaire was sent to the hospitals. In-depth interviews were conducted with pairs of nominated pharmacists at ten of these hospitals. The questionnaire focused on four areas: facilities, workforce, policies and clinical pharmacy activities. Main outcome measure Proportion of clinical pharmacy activities in hospitals. Themes in clinical pharmacy practice. Results 34/39 (87%) hospitals had established clinical pharmacy teams. Most activities were non-patient-specific (87%) while the preliminary patient-specific clinical pharmacy services were available in only 8/39 hospitals (21%). The most common non-patient-specific activities were providing medicines information (97%), reporting adverse drug reactions (97%), monitoring medication usage (97%). The patient specific activities varied widely between hospitals and were ad hoc. The main challenges reported were: lack of workforce and qualified clinical pharmacists. Conclusion While most hospitals had hospital-based pharmacy activities, the direct patient care was limited. Training, education and an expanded work forces are needed to improve clinical pharmacy services.

Infants' Selectively Pay Attention to the Information They Receive from a Native Speaker of Their Language.

PubMed

Marno, Hanna; Guellai, Bahia; Vidal, Yamil; Franzoi, Julia; Nespor, Marina; Mehler, Jacques

2016-01-01

From the first moments of their life, infants show a preference for their native language, as well as toward speakers with whom they share the same language. This preference appears to have broad consequences in various domains later on, supporting group affiliations and collaborative actions in children. Here, we propose that infants' preference for native speakers of their language also serves a further purpose, specifically allowing them to efficiently acquire culture specific knowledge via social learning. By selectively attending to informants who are native speakers of their language and who probably also share the same cultural background with the infant, young learners can maximize the possibility to acquire cultural knowledge. To test whether infants would preferably attend the information they receive from a speaker of their native language, we familiarized 12-month-old infants with a native and a foreign speaker, and then presented them with movies where each of the speakers silently gazed toward unfamiliar objects. At test, infants' looking behavior to the two objects alone was measured. Results revealed that infants preferred to look longer at the object presented by the native speaker. Strikingly, the effect was replicated also with 5-month-old infants, indicating an early development of such preference. These findings provide evidence that young infants pay more attention to the information presented by a person with whom they share the same language. This selectivity can serve as a basis for efficient social learning by influencing how infants' allocate attention between potential sources of information in their environment.

Accurate object tracking system by integrating texture and depth cues

NASA Astrophysics Data System (ADS)

Chen, Ju-Chin; Lin, Yu-Hang

2016-03-01

A robust object tracking system that is invariant to object appearance variations and background clutter is proposed. Multiple instance learning with a boosting algorithm is applied to select discriminant texture information between the object and background data. Additionally, depth information, which is important to distinguish the object from a complicated background, is integrated. We propose two depth-based models that can compensate texture information to cope with both appearance variants and background clutter. Moreover, in order to reduce the risk of drifting problem increased for the textureless depth templates, an update mechanism is proposed to select more precise tracking results to avoid incorrect model updates. In the experiments, the robustness of the proposed system is evaluated and quantitative results are provided for performance analysis. Experimental results show that the proposed system can provide the best success rate and has more accurate tracking results than other well-known algorithms.

Image visualization of hyperspectral spectrum for LWIR

NASA Astrophysics Data System (ADS)

Chong, Eugene; Jeong, Young-Su; Lee, Jai-Hoon; Park, Dong Jo; Kim, Ju Hyun

2015-07-01

The image visualization of a real-time hyperspectral spectrum in the long-wave infrared (LWIR) range of 900-1450 cm-1 by a color-matching function is addressed. It is well known that the absorption spectra of main toxic industrial chemical (TIC) and chemical warfare agent (CWA) clouds are detected in this spectral region. Furthermore, a significant spectral peak due to various background species and unknown targets are also present. However, those are dismissed as noise, resulting in utilization limit. Herein, we applied a color-matching function that uses the information from hyperspectral data, which is emitted from the materials and surfaces of artificial or natural backgrounds in the LWIR region. This information was used to classify and differentiate the background signals from the targeted substances, and the results were visualized as image data without additional visual equipment. The tristimulus value based visualization information can quickly identify the background species and target in real-time detection in LWIR.

Background and imaging simulations for the hard X-ray camera of the MIRAX mission

NASA Astrophysics Data System (ADS)

Castro, M.; Braga, J.; Penacchioni, A.; D'Amico, F.; Sacahui, R.

2016-07-01

We report the results of detailed Monte Carlo simulations of the performance expected both at balloon altitudes and at the probable satellite orbit of a hard X-ray coded-aperture camera being developed for the Monitor e Imageador de RAios X (MIRAX) mission. Based on a thorough mass model of the instrument and detailed specifications of the spectra and angular dependence of the various relevant radiation fields at both the stratospheric and orbital environments, we have used the well-known package GEANT4 to simulate the instrumental background of the camera. We also show simulated images of source fields to be observed and calculated the detailed sensitivity of the instrument in both situations. The results reported here are especially important to researchers in this field considering that we provide important information, not easily found in the literature, on how to prepare input files and calculate crucial instrumental parameters to perform GEANT4 simulations for high-energy astrophysics space experiments.

Participants’ perceptions and understanding of a malaria clinical trial in Bangladesh

PubMed Central

2014-01-01

Background Existing evidence suggests that there is often limited understanding among participants in clinical trials about the informed consent process, resulting in their providing consent without really understanding the purpose of the study, specific procedures, and their rights. The objective of the study was to determine the subjects’ understanding of research, perceptions of voluntariness and motivations for participation in a malaria clinical trial. Methods In this study semi-structured interviews of adult clinical trial participants with uncomplicated falciparum malaria were conducted in Ramu Upazila Health Complex, in Bangladesh. Results Of 16 participants, the vast majority (81%) were illiterate. All subjects had a ‘therapeutic misconception’ i.e. the trial was perceived to be conducted primarily for the benefit of individual patients when in fact the main objective was to provide information to inform public health policy. From the patients’ perspective, getting well from their illness was their major concern. Poor actual understanding of trial specific procedures was reported despite participants’ satisfaction with treatment and nursing care. Conclusion There is frequently a degree of overlap between research and provision of clinical care in malaria research studies. Patients may be motivated to participate to research without a good understanding of the principal objectives of the study despite a lengthy consent process. The findings suggest that use of a standard consent form following the current ICH-GCP guidelines does not result in achieving fully informed consent and the process should be revised, simplified and adapted to individual trial settings. PMID:24893933

Discrepancy between Medical Evidence Form 2728 and Renal Biopsy for Glomerular Diseases

PubMed Central

Hogan, Susan L.; Jennette, Caroline E.; Kenderes, Barbara; Krisher, Jenna; Jennette, J. Charles; McClellan, William M.

2010-01-01

Background and objectives: The United States Renal Data System (USRDS) is a commonly utilized database for epidemiologic research of ESRD patients. USRDS uses Medical Evidence Form 2728 to collect medical information about ESRD patients. The validity of the Form 2728 “primary cause of renal failure” field for glomerular diseases has not been evaluated, although inconsistencies between Form 2728 information and medical records have been documented previously with respect to comorbidities. Design, setting, participants, & measurements: Form 2728 information was linked with renal biopsy results from the Glomerular Disease Collaborative Network (GDCN) for 217 patients with biopsy-confirmed glomerular diseases who had reached ESRD. Biopsy results were compared with the Form 2728 “primary cause of renal failure” field. Diseases were considered individually, and also categorized into commonly used disease groups. Percentage of agreement and disease-specific measures of validity were calculated. Results: Overall agreement between renal biopsy and Form 2728 was low (14.8% overall, 23.0% when categorized). Agreement was better after Form 2728 was revised in 1995 (10.0% before versus 23.2% after overall). The cause of ESRD field was left blank in 57% of the forms submitted for glomerular disease patients. Individual glomerular diseases had very low specificities, but tended to have high positive predictive values. Conclusions: Form 2728 does not accurately reflect the renal pathology diagnosis as captured by biopsy. The large degree of missing data and misclassification should be of concern to those performing epidemiologic research using Form 2728 information on glomerular diseases. PMID:20688886

Scientific Integrity and Executive National Security Proclamations: A Conflict of the Modern Age

NASA Astrophysics Data System (ADS)

Nelson, R.; Banerdt, B.; Bell, J. L.; Byrnes, D. V.; Carlisle, G. L.; D'Addario, L. R.; Weissman, P. R.; Eisenhardt, P. R.; Foster, S. D.; Golombek, M. P.; Gorjian, V.; Gorjian, Z.; Hale, A. S.; Kulleck, J. G.; Laubach, S. L.; McElrath, T. P.; Penanen, K. I.; Satter, C.; Walker, W. J.

2010-12-01

In 2004, in response to the events of September, 11, 2001, President George W. Bush issued Homeland Security Presidential Directive #12, an executive order requiring a uniform means of identification (i.e. identification badge) for all employees and contractors at federal facilities. To comply with this directive NASA ordered that its contract employees at the Jet Propulsion Laboratory 'voluntarily' agree to an open ended, unrestricted, background investigation into the intimate details of their private lives. These employees do not have security clearances and do not work with classified material. Caltech, which employs the JPL personnel under a NASA management contract, informed the employees that if they did not ‘voluntarily’ consent to the background investigation, they would be assumed to have voluntarily resigned and therefore be denied access to JPL (i.e. they would be functionally terminated). In October 2007, twentyeight JPL employees filed suit in Federal District Court. After an initial dismissal by the lowest federal court, the Ninth Circuit Court of Appeals issued an injunction against Caltech and NASA, stopping the background investigations. The Appeals Court found that the investigations were not narrowly tailored to meet the specific needs of NASA and therefore violated the employee’s legitimate expectation of informational privacy. This injunction has been reviewed and upheld several times by various panels of the Ninth Circuit Court of Appeals. In November 2009, the United States Department of Justice petitioned the U.S. Supreme Court requesting that it overturn this injunction. The Supreme Court accepted the case for oral arguments and scheduled them for October 5, 2010. A decision is imminent (if it has not been made already). The case has opened the following questions regarding all research workers under government contract: 1. What impact would such intrusive investigations have on open scientific inquiry and scientific integrity? 2. How much can the Government reasonably ask about the backgrounds of its contract employees? 3. What rights do employees have to challenge the findings of their background investigations, and can the results of such investigations be contested in the courts? 4. What is the responsibility of a contract employer such as Caltech to protect the privacy of contract research workers like those at JPL? 5. What is the responsibility of professional societies in representing the interests of federal contract employees such as those at JPL? 6. What would constitute a reasonable background investigation of contract employees that would be narrowly tailored in order to protect informational privacy? This work is a private venture. Affiliations are listed for identification purposes only. No NASA, Caltech or JPL resources were expended in producing this abstract.

"We don't know her history, her background": adoptive parents' perspectives on whole genome sequencing results.

PubMed

Crouch, Julia; Yu, Joon-Ho; Shankar, Aditi G; Tabor, Holly K

2015-02-01

Exome sequencing and whole genome sequencing (ES/WGS) can provide parents with a wide range of genetic information about their children, and adoptive parents may have unique issues to consider regarding possible access to this information. The few papers published on adoption and genetics have focused on targeted genetic testing of children in the pre-adoption context. There are no data on adoptive parents' perspectives about pediatric ES/WGS, including their preferences about different kinds of results, and the potential benefits and risks of receiving results. To explore these issues, we conducted four exploratory focus groups with adoptive parents (N = 26). The majority lacked information about their children's biological family health history and ancestry, and many viewed WGS results as a way to fill in these gaps in knowledge. Some expressed concerns about protecting their children's future privacy and autonomy, but at the same time stated that WGS results could possibly help them be proactive about their children's health. A few parents expressed concerns about the risks of WGS in a pre-adoption context, specifically about decreasing a child's chance of adoption. These results suggest that issues surrounding genetic information in the post-adoption and ES/WGS contexts need to be considered, as well as concerns about risks in the pre-adoption context. A critical challenge for ES/WGS in the context of adoption will be balancing the right to know different kinds of genetic information with the right not to know. Specific guidance for geneticists and genetic counselors may be needed to maximize benefits of WGS while minimizing harms and prohibiting misuse of the information in the adoption process.

Web-Based Surveillance of Public Information Needs for Informing Preconception Interventions

PubMed Central

D’Ambrosio, Angelo; Agricola, Eleonora; Russo, Luisa; Gesualdo, Francesco; Pandolfi, Elisabetta; Bortolus, Renata; Castellani, Carlo; Lalatta, Faustina; Mastroiacovo, Pierpaolo; Tozzi, Alberto Eugenio

2015-01-01

Background The risk of adverse pregnancy outcomes can be minimized through the adoption of healthy lifestyles before pregnancy by women of childbearing age. Initiatives for promotion of preconception health may be difficult to implement. Internet can be used to build tailored health interventions through identification of the public's information needs. To this aim, we developed a semi-automatic web-based system for monitoring Google searches, web pages and activity on social networks, regarding preconception health. Methods Based on the American College of Obstetricians and Gynecologists guidelines and on the actual search behaviors of Italian Internet users, we defined a set of keywords targeting preconception care topics. Using these keywords, we analyzed the usage of Google search engine and identified web pages containing preconception care recommendations. We also monitored how the selected web pages were shared on social networks. We analyzed discrepancies between searched and published information and the sharing pattern of the topics. Results We identified 1,807 Google search queries which generated a total of 1,995,030 searches during the study period. Less than 10% of the reviewed pages contained preconception care information and in 42.8% information was consistent with ACOG guidelines. Facebook was the most used social network for sharing. Nutrition, Chronic Diseases and Infectious Diseases were the most published and searched topics. Regarding Genetic Risk and Folic Acid, a high search volume was not associated to a high web page production, while Medication pages were more frequently published than searched. Vaccinations elicited high sharing although web page production was low; this effect was quite variable in time. Conclusion Our study represent a resource to prioritize communication on specific topics on the web, to address misconceptions, and to tailor interventions to specific populations. PMID:25879682

TIMSS 2011 User Guide for the International Database. Supplement 2: National Adaptations of International Background Questionnaires

ERIC Educational Resources Information Center

Foy, Pierre, Ed.; Arora, Alka, Ed.; Stanco, Gabrielle M., Ed.

2013-01-01

This supplement describes national adaptations made to the international version of the TIMSS 2011 background questionnaires. This information provides users with a guide to evaluate the availability of internationally comparable data for use in secondary analyses involving the TIMSS 2011 background variables. Background questionnaire adaptations…

Using old technology to implement modern computer-aided decision support for primary diabetes care.

PubMed Central

Hunt, D. L.; Haynes, R. B.; Morgan, D.

2001-01-01

BACKGROUND: Implementation rates of interventions known to be beneficial for people with diabetes mellitus are often suboptimal. Computer-aided decision support systems (CDSSs) can improve these rates. The complexity of establishing a fully integrated electronic medical record that provides decision support, however, often prevents their use. OBJECTIVE: To develop a CDSS for diabetes care that can be easily introduced into primary care settings and diabetes clinics. THE SYSTEM: The CDSS uses fax-machine-based optical character recognition software for acquiring patient information. Simple, 1-page paper forms, completed by patients or health practitioners, are faxed to a central location. The information is interpreted and recorded in a database. This initiates a routine that matches the information against a knowledge base so that patient-specific recommendations can be generated. These are formatted and faxed back within 4-5 minutes. IMPLEMENTATION: The system is being introduced into 2 diabetes clinics. We are collecting information on frequency of use of the system, as well as satisfaction with the information provided. CONCLUSION: Computer-aided decision support can be provided in any setting with a fax machine, without the need for integrated electronic medical records or computerized data-collection devices. PMID:11825194

User Experiences of the McMaster Optimal Aging Portal’s Evidence Summaries and Blog Posts: Usability Study

PubMed Central

M Barbara, Angela; Dobbins, Maureen; Haynes, R Brian; Iorio, Alfonso; Lavis, John N

2016-01-01

Background Evidence summaries and blogs can support evidence-informed healthy aging, by presenting high-quality health research evidence in plain language for a nonprofessional (citizen) audience. Objective Our objective was to explore citizens’ perceptions about the usability of evidence summaries and blog posts on the Web-based McMaster Optimal Aging Portal. Methods Twenty-two citizens (aged 50 years and older) and informal caregivers participated in a qualitative study using a think-aloud method and semistructured interviews. Eleven interviews were conducted in person, 7 over the telephone, and 4 by Skype. Results We identified themes that fell under 4 user-experience categories: (1) desirability: personal relevance, (2) understandability: language comprehension, grasping the message, dealing with uncertainty, (3) usability: volume of information, use of numbers, and (4) usefulness: intention to use, facility for sharing. Conclusions Participants recognized that high-quality evidence on aging was valuable. Their intended use of the information was influenced by how much it applied to their own health circumstances or those of a loved one. Some specific formatting features that were preferred included consistent layout, content organized by subheadings, catchy titles, numerical information summarized in a table, and inclusion of a glossary. PMID:27542995

The Influence of Religion-Specific Background Knowledge on the Listening Comprehension of Adult Second-Language Students.

ERIC Educational Resources Information Center

Markham, Paul; Latham, Michael

1987-01-01

Assesses the influence of religious-specific background knowledge on adult ESL listening comprehension. Sixteen Moslems, 20 Christians, and 28 religion-neutral students listened to two passages, one on prayer rituals of Islam and one on those of Christianity. Students better recalled and understood the passage related to their respective religious…

Synthetic fiber production facilities: Background information for proposed standards

NASA Astrophysics Data System (ADS)

Goodwin, D. R.

1982-10-01

Standards of performance to control emissions of volatile organic compounds (VOC) from new, modified, and reconstructed synthetic fiber production facilities are being proposed under section III of the Clean Air Act. This document contains information on the background and authority, regulatory alternatives considered, and environmental and economic impacts of the regulatory alternatives.

The Effects of Background Information on Standarized Test Scores.

ERIC Educational Resources Information Center

Feeley, Joan T.; Wepner, Shelley B.

A study was conducted to determine the effects of exposure to the topics included on the comprehension subtest of the Nelson-Denny Reading Test (ND), Form F, on college freshmen's performance on the test. In addition, the study investigated whether those students with background information would indicate their awareness of this knowledge on a…

Mechanistic and quantitative insight into cell surface targeted molecular imaging agent design.

PubMed

Zhang, Liang; Bhatnagar, Sumit; Deschenes, Emily; Thurber, Greg M

2016-05-05

Molecular imaging agent design involves simultaneously optimizing multiple probe properties. While several desired characteristics are straightforward, including high affinity and low non-specific background signal, in practice there are quantitative trade-offs between these properties. These include plasma clearance, where fast clearance lowers background signal but can reduce target uptake, and binding, where high affinity compounds sometimes suffer from lower stability or increased non-specific interactions. Further complicating probe development, many of the optimal parameters vary depending on both target tissue and imaging agent properties, making empirical approaches or previous experience difficult to translate. Here, we focus on low molecular weight compounds targeting extracellular receptors, which have some of the highest contrast values for imaging agents. We use a mechanistic approach to provide a quantitative framework for weighing trade-offs between molecules. Our results show that specific target uptake is well-described by quantitative simulations for a variety of targeting agents, whereas non-specific background signal is more difficult to predict. Two in vitro experimental methods for estimating background signal in vivo are compared - non-specific cellular uptake and plasma protein binding. Together, these data provide a quantitative method to guide probe design and focus animal work for more cost-effective and time-efficient development of molecular imaging agents.

Tool for Constructing Data Albums for Significant Weather Events

NASA Astrophysics Data System (ADS)

Kulkarni, A.; Ramachandran, R.; Conover, H.; McEniry, M.; Goodman, H.; Zavodsky, B. T.; Braun, S. A.; Wilson, B. D.

2012-12-01

Case study analysis and climatology studies are common approaches used in Atmospheric Science research. Research based on case studies involves a detailed description of specific weather events using data from different sources, to characterize physical processes in play for a given event. Climatology-based research tends to focus on the representativeness of a given event, by studying the characteristics and distribution of a large number of events. To gather relevant data and information for case studies and climatology analysis is tedious and time consuming; current Earth Science data systems are not suited to assemble multi-instrument, multi mission datasets around specific events. For example, in hurricane science, finding airborne or satellite data relevant to a given storm requires searching through web pages and data archives. Background information related to damages, deaths, and injuries requires extensive online searches for news reports and official storm summaries. We will present a knowledge synthesis engine to create curated "Data Albums" to support case study analysis and climatology studies. The technological challenges in building such a reusable and scalable knowledge synthesis engine are several. First, how to encode domain knowledge in a machine usable form? This knowledge must capture what information and data resources are relevant and the semantic relationships between the various fragments of information and data. Second, how to extract semantic information from various heterogeneous sources including unstructured texts using the encoded knowledge? Finally, how to design a structured database from the encoded knowledge to store all information and to support querying? The structured database must allow both knowledge overviews of an event as well as drill down capability needed for detailed analysis. An application ontology driven framework is being used to design the knowledge synthesis engine. The knowledge synthesis engine is being applied to build a portal for hurricane case studies at the Global Hydrology and Resource Center (GHRC), a NASA Data Center. This portal will auto-generate Data Albums for specific hurricane events, compiling information from distributed resources such as NASA field campaign collections, relevant data sets, storm reports, pictures, videos and other useful sources.

HMPAS: Human Membrane Protein Analysis System

PubMed Central

2013-01-01

Background Membrane proteins perform essential roles in diverse cellular functions and are regarded as major pharmaceutical targets. The significance of membrane proteins has led to the developing dozens of resources related with membrane proteins. However, most of these resources are built for specific well-known membrane protein groups, making it difficult to find common and specific features of various membrane protein groups. Methods We collected human membrane proteins from the dispersed resources and predicted novel membrane protein candidates by using ortholog information and our membrane protein classifiers. The membrane proteins were classified according to the type of interaction with the membrane, subcellular localization, and molecular function. We also made new feature dataset to characterize the membrane proteins in various aspects including membrane protein topology, domain, biological process, disease, and drug. Moreover, protein structure and ICD-10-CM based integrated disease and drug information was newly included. To analyze the comprehensive information of membrane proteins, we implemented analysis tools to identify novel sequence and functional features of the classified membrane protein groups and to extract features from protein sequences. Results We constructed HMPAS with 28,509 collected known membrane proteins and 8,076 newly predicted candidates. This system provides integrated information of human membrane proteins individually and in groups organized by 45 subcellular locations and 1,401 molecular functions. As a case study, we identified associations between the membrane proteins and diseases and present that membrane proteins are promising targets for diseases related with nervous system and circulatory system. A web-based interface of this system was constructed to facilitate researchers not only to retrieve organized information of individual proteins but also to use the tools to analyze the membrane proteins. Conclusions HMPAS provides comprehensive information about human membrane proteins including specific features of certain membrane protein groups. In this system, user can acquire the information of individual proteins and specified groups focused on their conserved sequence features, involved cellular processes, and diseases. HMPAS may contribute as a valuable resource for the inference of novel cellular mechanisms and pharmaceutical targets associated with the human membrane proteins. HMPAS is freely available at http://fcode.kaist.ac.kr/hmpas. PMID:24564858

A Study of Nuclear Recoil Backgrounds in Dark Matter Detectors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Westerdale, Shawn S.

2016-01-01

Despite the great success of the Standard Model of particle physics, a preponderance of astrophysical evidence suggests that it cannot explain most of the matter in the universe. This so-called dark matter has eluded direct detection, though many theoretical extensions to the Standard Model predict the existence of particles with a mass on themore » $1-1000$ GeV scale that interact only via the weak nuclear force. Particles in this class are referred to as Weakly Interacting Massive Particles (WIMPs), and their high masses and low scattering cross sections make them viable dark matter candidates. The rarity of WIMP-nucleus interactions makes them challenging to detect: any background can mask the signal they produce. Background rejection is therefore a major problem in dark matter detection. Many experiments greatly reduce their backgrounds by employing techniques to reject electron recoils. However, nuclear recoil backgrounds, which produce signals similar to what we expect from WIMPs, remain problematic. There are two primary sources of such backgrounds: surface backgrounds and neutron recoils. Surface backgrounds result from radioactivity on the inner surfaces of the detector sending recoiling nuclei into the detector. These backgrounds can be removed with fiducial cuts, at some cost to the experiment's exposure. In this dissertation we briefly discuss a novel technique for rejecting these events based on signals they make in the wavelength shifter coating on the inner surfaces of some detectors. Neutron recoils result from neutrons scattering from nuclei in the detector. These backgrounds may produce a signal identical to what we expect from WIMPs and are extensively discussed here. We additionally present a new tool for calculating ($$\\alpha$$, n)yields in various materials. We introduce the concept of a neutron veto system designed to shield against, measure, and provide an anti-coincidence veto signal for background neutrons. We discuss the research and development that informed the design of the DarkSide-50 boron-loaded liquid scintillator neutron veto. We describe the specific implementation of this veto system in DarkSide-50, including a description of its performance, and show that it can reject neutrons with a high enough e_ciency to allow DarkSide-50 to run background-free for three years.« less

Manned Systems Utilization Analysis. Study 2.1: Space Servicing Pilot Program Study. [for automated payloads

NASA Technical Reports Server (NTRS)

Wolfe, R. R.

1975-01-01

Space servicing automated payloads was studied for potential cost benefits for future payload operations. Background information is provided on space servicing in general, and on a pilot flight test program in particular. An fight test is recommended to demonstrate space servicing. An overall program plan is provided which builds upon the pilot program through an interim servicing capability. A multipayload servicing concept for the time when the full capability tug becomes operational is presented. The space test program is specifically designed to provide low-cost booster vehicles and a flight test platform for several experiments on a single flight.

A 10-MWe solar-thermal central-receiver pilot plant: Solar facilities design integration. Plant operating/training manual (RADL-Item 2-36)

NASA Astrophysics Data System (ADS)

1982-07-01

Plant and system level operating instructions are provided for the Barstow Solar Pilot Plant. Individual status instructions are given that identify plant conditions, process controller responsibilities, process conditions and control accuracies, operating envelopes, and operator cautions appropriate to the operating condition. Transition operating instructions identify the sequence of activities to be carried out to accomplish the indicated transition. Most transitions involve the startup or shutdown of an individual flowpath. Background information is provided on collector field operations, and the heliostat groupings and specific commands used in support receiver startup are defined.

National Athletic Trainers' Association Position Statement: Skin Diseases

PubMed Central

Zinder, Steven M.; Basler, Rodney S. W.; Foley, Jack; Scarlata, Chris; Vasily, David B.

2010-01-01

Abstract Objective: To present recommendations for the prevention, education, and management of skin infections in athletes. Background: Trauma, environmental factors, and infectious agents act together to continually attack the integrity of the skin. Close quarters combined with general poor hygiene practices make athletes particularly vulnerable to contracting skin diseases. An understanding of basic prophylactic measures, clinical features, and swift management of common skin diseases is essential for certified athletic trainers to aid in preventing the spread of infectious agents. Recommendations: These guidelines are intended to provide relevant information on skin infections and to give specific recommendations for certified athletic trainers and others participating in athletic health care. PMID:20617918

Verification of EPA's " Preliminary remediation goals for radionuclides" (PRG) electronic calculator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stagich, B. H.

The U.S. Environmental Protection Agency (EPA) requested an external, independent verification study of their “Preliminary Remediation Goals for Radionuclides” (PRG) electronic calculator. The calculator provides information on establishing PRGs for radionuclides at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) sites with radioactive contamination (Verification Study Charge, Background). These risk-based PRGs set concentration limits using carcinogenic toxicity values under specific exposure conditions (PRG User’s Guide, Section 1). The purpose of this verification study is to ascertain that the computer codes has no inherit numerical problems with obtaining solutions as well as to ensure that the equations are programmed correctly.

International Data Base for the U.S. Renewable Energy Industry

DOE Office of Scientific and Technical Information (OSTI.GOV)

none

1986-05-01

The International Data Base for the US Renewable Energy Industry was developed to provide the US renewable energy industry with background data for identifying and analyzing promising foreign market opportunities for their products and services. Specifically, the data base provides the following information for 161 developed and developing countries: (1) General Country Data--consisting of general energy indicators; (2) Energy Demand Data--covering commercial primary energy consumption; (3) Energy Resource Data--identifying annual average insolation, wind power, and river flow data; (4) Power System Data--indicating a wide range of electrical parameters; and (5) Business Data--including currency and credit worthiness data.

Low-speed single-element airfoil synthesis

NASA Technical Reports Server (NTRS)

Mcmasters, J. H.; Henderson, M. L.

1979-01-01

The use of recently developed airfoil analysis/design computational tools to clarify, enrich and extend the existing experimental data base on low-speed, single element airfoils is demonstrated. A discussion of the problem of tailoring an airfoil for a specific application at its appropriate Reynolds number is presented. This problem is approached by use of inverse (or synthesis) techniques, wherein a desirable set of boundary layer characteristics, performance objectives, and constraints are specified, which then leads to derivation of a corresponding viscous flow pressure distribution. Examples are presented which demonstrate the synthesis approach, following presentation of some historical information and background data which motivate the basic synthesis process.

47 CFR 215.1 - Background.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 5 2012-10-01 2012-10-01 false Background. 215.1 Section 215.1 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL FEDERAL GOVERNMENT FOCAL POINT FOR ELECTROMAGNETIC PULSE (EMP) INFORMATION § 215.1 Background. (a) The nuclear electromagnetic...

47 CFR 215.1 - Background.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 5 2014-10-01 2014-10-01 false Background. 215.1 Section 215.1 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL FEDERAL GOVERNMENT FOCAL POINT FOR ELECTROMAGNETIC PULSE (EMP) INFORMATION § 215.1 Background. (a) The nuclear electromagnetic...

47 CFR 215.1 - Background.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false Background. 215.1 Section 215.1 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL FEDERAL GOVERNMENT FOCAL POINT FOR ELECTROMAGNETIC PULSE (EMP) INFORMATION § 215.1 Background. (a) The nuclear electromagnetic...

47 CFR 215.1 - Background.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 5 2013-10-01 2013-10-01 false Background. 215.1 Section 215.1 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL FEDERAL GOVERNMENT FOCAL POINT FOR ELECTROMAGNETIC PULSE (EMP) INFORMATION § 215.1 Background. (a) The nuclear electromagnetic...

47 CFR 215.1 - Background.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 5 2011-10-01 2011-10-01 false Background. 215.1 Section 215.1 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL FEDERAL GOVERNMENT FOCAL POINT FOR ELECTROMAGNETIC PULSE (EMP) INFORMATION § 215.1 Background. (a) The nuclear electromagnetic...

76 FR 79565 - Management Contracts-Background Investigations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-22

... Management Contracts--Background Investigations AGENCY: National Indian Gaming Commission. ACTION: Notice of... investigation process required for management contracts. The proposed revision may reduce duplication of efforts... to clarify that a management contractor should be required to submit background information when the...

Identification of amino acid residues involved in substrate specificity of plant acyl-ACP thioesterases using a bioinformatics-guided approach

PubMed Central

Mayer, Kimberly M; Shanklin, John

2007-01-01

Background The large amount of available sequence information for the plant acyl-ACP thioesterases (TEs) made it possible to use a bioinformatics-guided approach to identify amino acid residues involved in substrate specificity. The Conserved Property Difference Locator (CPDL) program allowed the identification of putative specificity-determining residues that differ between the FatA and FatB TE classes. Six of the FatA residue differences identified by CPDL were incorporated into the FatB-like parent via site-directed mutagenesis and the effect of each on TE activity was determined. Variants were expressed in E. coli strain K27 that allows determination of enzyme activity by GCMS analysis of fatty acids released into the medium. Results Substitutions at four of the positions (74, 86, 141, and 174) changed substrate specificity to varying degrees while changes at the remaining two positions, 110 and 221, essentially inactivated the thioesterase. The effects of substitutions at positions 74, 141, and 174 (3-MUT) or 74, 86, 141, 174 (4-MUT) were not additive with respect to specificity. Conclusion Four of six putative specificity determining positions in plant TEs, identified with the use of CPDL, were validated experimentally; a novel colorimetric screen that discriminates between active and inactive TEs is also presented. PMID:17201914

A RCT Comparing Specific Intensive Cognitive Training to Aspecific Psychological Intervention in RRMS: The SMICT Study

PubMed Central

Mattioli, Flavia; Stampatori, Chiara; Bellomi, Fabio; Danni, Maura; Compagnucci, Laura; Uccelli, Antonio; Pardini, Matteo; Santuccio, Giuseppe; Fregonese, Giuditta; Pattini, Marianna; Allegri, Beatrice; Clerici, Raffaella; Lattuada, Annalisa; Montomoli, Cristina; Corso, Barbara; Capra, Ruggero

2015-01-01

Background: Specific cognitive rehabilitation in multiple sclerosis (MS) resulted to be effective compared to no treatment. So far the possible role of an aspecific psychological intervention on cognition has not been investigated. Objective: The aim of the SMICT RCT was to compare the efficacy of a specific cognitive training with an aspecific psychological intervention in relapsing-remitting MS patients. Methods: From a sample of 150 patients, with the same disability and immunomodulatory therapy, submitted to neuropsychological examination, 45 impaired in at least one test were included and 41 randomized to have either a specific cognitive training for the impaired function (22) or to an aspecific psychological intervention (19) for 4 months, starting after baseline examination. Neuropsychological tests and functional scales were administered at baseline and 1 year later. Results: After 1 year, the mean number of pathological tests was significantly lower in the specific treatment group, compared to the aspecific group. Memory and attention/speeded information processing functions were mostly improved. Depression and quality of life were not different between groups at follow up. Conclusion: Our study demonstrates that an intensive and domain specific cognitive approach results to be more effective than aspecific psychological intervention in patients with MS. PMID:25628596

Automated epidermis segmentation in histopathological images of human skin stained with hematoxylin and eosin

NASA Astrophysics Data System (ADS)

Kłeczek, Paweł; Dyduch, Grzegorz; Jaworek-Korjakowska, Joanna; Tadeusiewicz, Ryszard

2017-03-01

Background: Epidermis area is an important observation area for the diagnosis of inflammatory skin diseases and skin cancers. Therefore, in order to develop a computer-aided diagnosis system, segmentation of the epidermis area is usually an essential, initial step. This study presents an automated and robust method for epidermis segmentation in whole slide histopathological images of human skin, stained with hematoxylin and eosin. Methods: The proposed method performs epidermis segmentation based on the information about shape and distribution of transparent regions in a slide image and information about distribution and concentration of hematoxylin and eosin stains. It utilizes domain-specific knowledge of morphometric and biochemical properties of skin tissue elements to segment the relevant histopathological structures in human skin. Results: Experimental results on 88 skin histopathological images from three different sources show that the proposed method segments the epidermis with a mean sensitivity of 87 %, a mean specificity of 95% and a mean precision of 57%. It is robust to inter- and intra-image variations in both staining and illumination, and makes no assumptions about the type of skin disorder. The proposed method provides a superior performance compared to the existing techniques.

Scripts for TRUMP data analyses. Part II (HLA-related data): statistical analyses specific for hematopoietic stem cell transplantation.

PubMed

Kanda, Junya

2016-01-01

The Transplant Registry Unified Management Program (TRUMP) made it possible for members of the Japan Society for Hematopoietic Cell Transplantation (JSHCT) to analyze large sets of national registry data on autologous and allogeneic hematopoietic stem cell transplantation. However, as the processes used to collect transplantation information are complex and differed over time, the background of these processes should be understood when using TRUMP data. Previously, information on the HLA locus of patients and donors had been collected using a questionnaire-based free-description method, resulting in some input errors. To correct minor but significant errors and provide accurate HLA matching data, the use of a Stata or EZR/R script offered by the JSHCT is strongly recommended when analyzing HLA data in the TRUMP dataset. The HLA mismatch direction, mismatch counting method, and different impacts of HLA mismatches by stem cell source are other important factors in the analysis of HLA data. Additionally, researchers should understand the statistical analyses specific for hematopoietic stem cell transplantation, such as competing risk, landmark analysis, and time-dependent analysis, to correctly analyze transplant data. The data center of the JSHCT can be contacted if statistical assistance is required.

Probabilistic drug connectivity mapping

PubMed Central

2014-01-01

Background The aim of connectivity mapping is to match drugs using drug-treatment gene expression profiles from multiple cell lines. This can be viewed as an information retrieval task, with the goal of finding the most relevant profiles for a given query drug. We infer the relevance for retrieval by data-driven probabilistic modeling of the drug responses, resulting in probabilistic connectivity mapping, and further consider the available cell lines as different data sources. We use a special type of probabilistic model to separate what is shared and specific between the sources, in contrast to earlier connectivity mapping methods that have intentionally aggregated all available data, neglecting information about the differences between the cell lines. Results We show that the probabilistic multi-source connectivity mapping method is superior to alternatives in finding functionally and chemically similar drugs from the Connectivity Map data set. We also demonstrate that an extension of the method is capable of retrieving combinations of drugs that match different relevant parts of the query drug response profile. Conclusions The probabilistic modeling-based connectivity mapping method provides a promising alternative to earlier methods. Principled integration of data from different cell lines helps to identify relevant responses for specific drug repositioning applications. PMID:24742351

GDA, a web-based tool for Genomics and Drugs integrated analysis.

PubMed

Caroli, Jimmy; Sorrentino, Giovanni; Forcato, Mattia; Del Sal, Giannino; Bicciato, Silvio

2018-05-25

Several major screenings of genetic profiling and drug testing in cancer cell lines proved that the integration of genomic portraits and compound activities is effective in discovering new genetic markers of drug sensitivity and clinically relevant anticancer compounds. Despite most genetic and drug response data are publicly available, the availability of user-friendly tools for their integrative analysis remains limited, thus hampering an effective exploitation of this information. Here, we present GDA, a web-based tool for Genomics and Drugs integrated Analysis that combines drug response data for >50 800 compounds with mutations and gene expression profiles across 73 cancer cell lines. Genomic and pharmacological data are integrated through a modular architecture that allows users to identify compounds active towards cancer cell lines bearing a specific genomic background and, conversely, the mutational or transcriptional status of cells responding or not-responding to a specific compound. Results are presented through intuitive graphical representations and supplemented with information obtained from public repositories. As both personalized targeted therapies and drug-repurposing are gaining increasing attention, GDA represents a resource to formulate hypotheses on the interplay between genomic traits and drug response in cancer. GDA is freely available at http://gda.unimore.it/.

Development of ultralow energy (1–10 eV) ion scattering spectrometry coupled with reflection absorption infrared spectroscopy and temperature programmed desorption for the investigation of molecular solids

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bag, Soumabha; Bhuin, Radha Gobinda; Methikkalam, Rabin Rajan J.

2014-01-15

Extremely surface specific information, limited to the first atomic layer of molecular surfaces, is essential to understand the chemistry and physics in upper atmospheric and interstellar environments. Ultra low energy ion scattering in the 1–10 eV window with mass selected ions can reveal extremely surface specific information which when coupled with reflection absorption infrared (RAIR) and temperature programmed desorption (TPD) spectroscopies, diverse chemical and physical properties of molecular species at surfaces could be derived. These experiments have to be performed at cryogenic temperatures and at ultra high vacuum conditions without the possibility of collisions of neutrals and background deposition inmore » view of the poor ion intensities and consequent need for longer exposure times. Here we combine a highly optimized low energy ion optical system designed for such studies coupled with RAIR and TPD and its initial characterization. Despite the ultralow collision energies and long ion path lengths employed, the ion intensities at 1 eV have been significant to collect a scattered ion spectrum of 1000 counts/s for mass selected CH{sub 2}{sup +}.« less

Whole genome comparative studies between chicken and turkey and their implications for avian genome evolution

PubMed Central

Griffin, Darren K; Robertson, Lindsay B; Tempest, Helen G; Vignal, Alain; Fillon, Valérie; Crooijmans, Richard PMA; Groenen, Martien AM; Deryusheva, Svetlana; Gaginskaya, Elena; Carré, Wilfrid; Waddington, David; Talbot, Richard; Völker, Martin; Masabanda, Julio S; Burt, Dave W

2008-01-01

Background Comparative genomics is a powerful means of establishing inter-specific relationships between gene function/location and allows insight into genomic rearrangements, conservation and evolutionary phylogeny. The availability of the complete sequence of the chicken genome has initiated the development of detailed genomic information in other birds including turkey, an agriculturally important species where mapping has hitherto focused on linkage with limited physical information. No molecular study has yet examined conservation of avian microchromosomes, nor differences in copy number variants (CNVs) between birds. Results We present a detailed comparative cytogenetic map between chicken and turkey based on reciprocal chromosome painting and mapping of 338 chicken BACs to turkey metaphases. Two inter-chromosomal changes (both involving centromeres) and three pericentric inversions have been identified between chicken and turkey; and array CGH identified 16 inter-specific CNVs. Conclusion This is the first study to combine the modalities of zoo-FISH and array CGH between different avian species. The first insight into the conservation of microchromosomes, the first comparative cytogenetic map of any bird and the first appraisal of CNVs between birds is provided. Results suggest that avian genomes have remained relatively stable during evolution compared to mammalian equivalents. PMID:18410676

Detection experiments with humans implicate visual predation as a driver of colour polymorphism dynamics in pygmy grasshoppers

PubMed Central

2013-01-01

Background Animal colour patterns offer good model systems for studies of biodiversity and evolution of local adaptations. An increasingly popular approach to study the role of selection for camouflage for evolutionary trajectories of animal colour patterns is to present images of prey on paper or computer screens to human ‘predators’. Yet, few attempts have been made to confirm that rates of detection by humans can predict patterns of selection and evolutionary modifications of prey colour patterns in nature. In this study, we first analyzed encounters between human ‘predators’ and images of natural black, grey and striped colour morphs of the polymorphic Tetrix subulata pygmy grasshoppers presented on background images of unburnt, intermediate or completely burnt natural habitats. Next, we compared detection rates with estimates of capture probabilities and survival of free-ranging grasshoppers, and with estimates of relative morph frequencies in natural populations. Results The proportion of grasshoppers that were detected and time to detection depended on both the colour pattern of the prey and on the type of visual background. Grasshoppers were detected more often and faster on unburnt backgrounds than on 50% and 100% burnt backgrounds. Striped prey were detected less often than grey or black prey on unburnt backgrounds; grey prey were detected more often than black or striped prey on 50% burnt backgrounds; and black prey were detected less often than grey prey on 100% burnt backgrounds. Rates of detection mirrored previously reported rates of capture by humans of free-ranging grasshoppers, as well as morph specific survival in the wild. Rates of detection were also correlated with frequencies of striped, black and grey morphs in samples of T. subulata from natural populations that occupied the three habitat types used for the detection experiment. Conclusions Our findings demonstrate that crypsis is background-dependent, and implicate visual predation as an important driver of evolutionary modifications of colour polymorphism in pygmy grasshoppers. Our study provides the clearest evidence to date that using humans as ‘predators’ in detection experiments may provide reliable information on the protective values of prey colour patterns and of natural selection and microevolution of camouflage in the wild. PMID:23639215

Sharing clinical information across care settings: the birth of an integrated assessment system

PubMed Central

Gray, Leonard C; Berg, Katherine; Fries, Brant E; Henrard, Jean-Claude; Hirdes, John P; Steel, Knight; Morris, John N

2009-01-01

Background Population ageing, the emergence of chronic illness, and the shift away from institutional care challenge conventional approaches to assessment systems which traditionally are problem and setting specific. Methods From 2002, the interRAI research collaborative undertook development of a suite of assessment tools to support assessment and care planning of persons with chronic illness, frailty, disability, or mental health problems across care settings. The suite constitutes an early example of a "third generation" assessment system. Results The rationale and development strategy for the suite is described, together with a description of potential applications. To date, ten instruments comprise the suite, each comprising "core" items shared among the majority of instruments and "optional" items that are specific to particular care settings or situations. Conclusion This comprehensive suite offers the opportunity for integrated multi-domain assessment, enabling electronic clinical records, data transfer, ease of interpretation and streamlined training. PMID:19402891

Leadership training in science, technology, engineering and mathematics education in Bulgaria

NASA Astrophysics Data System (ADS)

Bairaktarova, Diana; Cox, Monica F.; Evangelou, Demetra

2011-12-01

This synthesis paper explores current leadership training in science, technology, engineering and mathematics (STEM) education in Bulgaria. The analysis begins with discussion of global factors influencing the implementation of leadership training in STEM education in general and then presents information about the current status of leadership training in Bulgaria with emphases on the country's economics, politics and geographical location as specific factors influencing leadership education. A short background of Bulgaria is presented with regard to population, gross domestic product, educational system, engineering force and possible need for leaders in industry in Bulgaria and the European Union. The paper provides an overall view about the current status of leadership training in all Bulgarian universities offering STEM education and concentrates specifically on two major universities by examining their currently offered programmes. As part of the discussion, similar training elements in other European countries and the USA are presented.

Short Stature—Physiology and Pathology

PubMed Central

Rimoin, David L.; Borochowitz, Zvi; Horton, William A.

1986-01-01

Stature, the quantitative measure of height, varies widely within each ethnic group with a fairly normal distribution. Of the numerous patients whom physicians encounter because of short stature, relatively few are pathologically small in the context of family and ethnic background. Physicians must be able to differentiate pathologic short stature from the lower end of the normal curve before embarking on a complex diagnostic evaluation. There are literally hundreds of different causes of short stature, and the clinical evaluation requires a wide variety of clinical, radiographic, pathologic and biochemical tools. Although specific treatment to promote growth is available only in persons with the endocrinopathies and the acquired nutritional, emotional and chronic disease states, diagnosis of the specific form of short stature can have great importance in being able to prevent complications and to offer accurate prognostic information and genetic counseling. ImagesFigure 2.Figure 3. PMID:2873688

Capturing a failure of an ASIC in-situ, using infrared radiometry and image processing software

NASA Technical Reports Server (NTRS)

Ruiz, Ronald P.

2003-01-01

Failures in electronic devices can sometimes be tricky to locate-especially if they are buried inside radiation-shielded containers designed to work in outer space. Such was the case with a malfunctioning ASIC (Application Specific Integrated Circuit) that was drawing excessive power at a specific temperature during temperature cycle testing. To analyze the failure, infrared radiometry (thermography) was used in combination with image processing software to locate precisely where the power was being dissipated at the moment the failure took place. The IR imaging software was used to make the image of the target and background, appear as unity. As testing proceeded and the failure mode was reached, temperature changes revealed the precise location of the fault. The results gave the design engineers the information they needed to fix the problem. This paper describes the techniques and equipment used to accomplish this failure analysis.

Management of Cardiac Involvement Associated With Neuromuscular Diseases: A Scientific Statement From the American Heart Association.

PubMed

Feingold, Brian; Mahle, William T; Auerbach, Scott; Clemens, Paula; Domenighetti, Andrea A; Jefferies, John L; Judge, Daniel P; Lal, Ashwin K; Markham, Larry W; Parks, W James; Tsuda, Takeshi; Wang, Paul J; Yoo, Shi-Joon

2017-09-26

For many neuromuscular diseases (NMDs), cardiac disease represents a major cause of morbidity and mortality. The management of cardiac disease in NMDs is made challenging by the broad clinical heterogeneity that exists among many NMDs and by limited knowledge about disease-specific cardiovascular pathogenesis and course-modifying interventions. The overlay of compromise in peripheral muscle function and other organ systems, such as the lungs, also makes the simple application of endorsed adult or pediatric heart failure guidelines to the NMD population problematic. In this statement, we provide background on several NMDs in which there is cardiac involvement, highlighting unique features of NMD-associated myocardial disease that require clinicians to tailor their approach to prevention and treatment of heart failure. Undoubtedly, further investigations are required to best inform future guidelines on NMD-specific cardiovascular health risks, treatments, and outcomes. © 2017 American Heart Association, Inc.

New criteria for supplementation of selected micronutrients in the era of nutrigenetics and nutrigenomics.

PubMed

Schwartz, Betty

2014-08-01

Advances in molecular biology, emergence of novel techniques and huge amount of information generated in the post-Human Genome Project era have fostered the emergence of new disciplines in the field of nutritional research: Nutrigenomics deals with the effect of diet on gene expression whereas nutrigenetics refers to the impact of inherited traits on the response to a specific dietary pattern, functional food or supplement. Understanding the role of micronutrient supplementation with specific genetic backgrounds may provide an important contribution to a new optimum health strategy based on individualized nutritional treatment and may provide the strategies for the development of safer and more effective dietary interventions. This overview of the various aspects of supplementation of micronutrients in the era of nutrigenetics and nutrigenomics may provide a better understanding of novel nutritional research approach and provide an additional insight that can be applied to the daily dietary practice.

WAG 2 remedial investigation and site investigation site-specific work plan/health and safety checklist for the ecological assessment task, Kingfisher Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Holt, V.L.; Baron, L.A.

1994-05-01

This report provides specific details and requirements for the WAG 2 remedial investigation and site investigation Ecological Assessment Task, Kingfisher Study, including information that will contribute to safe completion of the project. The report includes historical background; a site map; project organization; task descriptions and hazard evaluations; controls; and monitoring, personal protective equipment, decontamination, and medical surveillance program requirements. The report also includes descriptions of site personnel and their certifications as well as suspected WAG 2 contaminants and their characteristics. The primary objective of the WAG 2 Kingfisher Study is to assess the feasibility of using kingfishers as biological monitorsmore » of contaminants on the Oak Ridge Reservation (ORR). Kingfisher sample collection will be used to determine the levels of contaminants and degree of bioaccumulation within a common piscivorous bird feeding on contaminated fish from streams on the ORR.« less

Metabolism Disrupting Chemicals and Metabolic Disorders

PubMed Central

Heindel, Jerrold J.; Blumberg, Bruce; Cave, Mathew; Machtinger, Ronit; Mantovani, Alberto; Mendez, Michelle A.; Nadal, Angel; Palanza, Paola; Panzica, Giancarlo; Sargis, Robert; Vandenberg, Laura N.; Saal, Frederick vom

2016-01-01

The recent epidemics of metabolic diseases, obesity, type 2 diabetes(T2D), liver lipid disorders and metabolic syndrome have largely been attributed to genetic background and changes in diet, exercise and aging. However, there is now considerable evidence that other environmental factors may contribute to the rapid increase in the incidence of these metabolic diseases. This review will examine changes to the incidence of obesity, T2D and non-alcoholic fatty liver disease (NAFLD), the contribution of genetics to these disorders and describe the role of the endocrine system in these metabolic disorders. It will then specifically focus on the role of endocrine disrupting chemicals (EDCs) in the etiology of obesity, T2D and NAFLD while finally integrating the information on EDCs on multiple metabolic disorders that could lead to metabolic syndrome. We will specifically examine evidence linking EDC exposures during critical periods of development with metabolic diseases that manifest later in life and across generations. PMID:27760374

Climate change and health effects in Northwest Alaska

PubMed Central

Brubaker, Michael; Berner, James; Chavan, Raj; Warren, John

2011-01-01

This article provides examples of adverse health effects, including weather-related injury, food insecurity, mental health issues, and water infrastructure damage, and the responses to these effects that are currently being applied in two Northwest Alaska communities. Background In Northwest Alaska, warming is resulting in a broad range of unusual weather and environmental conditions, including delayed freeze-up, earlier breakup, storm surge, coastal erosion, and thawing permafrost. These are just some of the climate impacts that are driving concerns about weather-related injury, the spread of disease, mental health issues, infrastructure damage, and food and water security. Local leaders are challenged to identify appropriate adaptation strategies to address climate impacts and related health effects. Implementation process The tribal health system is combining local observations, traditional knowledge, and western science to perform community-specific climate change health impact assessments. Local leaders are applying this information to develop adaptation responses. Objective The Alaska Native Tribal Health Consortium will describe relationships between climate impacts and health effects and provide examples of community-scaled adaptation actions currently being applied in Northwest Alaska. Findings Climate change is increasing vulnerability to injury, disease, mental stress, food insecurity, and water insecurity. Northwest communities are applying adaptation approaches that are both specific and appropriate. Conclusion The health impact assessment process is effective in raising awareness, encouraging discussion, engaging partners, and implementing adaptation planning. With community-specific information, local leaders are applying health protective adaptation measures. PMID:22022304

Evidence for somatic gene conversion and deletion in bipolar disorder, Crohn's disease, coronary artery disease, hypertension, rheumatoid arthritis, type-1 diabetes, and type-2 diabetes

PubMed Central

2011-01-01

Background During gene conversion, genetic information is transferred unidirectionally between highly homologous but non-allelic regions of DNA. While germ-line gene conversion has been implicated in the pathogenesis of some diseases, somatic gene conversion has remained technically difficult to investigate on a large scale. Methods A novel analysis technique is proposed for detecting the signature of somatic gene conversion from SNP microarray data. The Wellcome Trust Case Control Consortium has gathered SNP microarray data for two control populations and cohorts for bipolar disorder (BD), cardiovascular disease (CAD), Crohn's disease (CD), hypertension (HT), rheumatoid arthritis (RA), type-1 diabetes (T1D) and type-2 diabetes (T2D). Using the new analysis technique, the seven disease cohorts are analyzed to identify cohort-specific SNPs at which conversion is predicted. The quality of the predictions is assessed by identifying known disease associations for genes in the homologous duplicons, and comparing the frequency of such associations with background rates. Results Of 28 disease/locus pairs meeting stringent conditions, 22 show various degrees of disease association, compared with only 8 of 70 in a mock study designed to measure the background association rate (P < 10-9). Additional candidate genes are identified using less stringent filtering conditions. In some cases, somatic deletions appear likely. RA has a distinctive pattern of events relative to other diseases. Similarities in patterns are apparent between BD and HT. Conclusions The associations derived represent the first evidence that somatic gene conversion could be a significant causative factor in each of the seven diseases. The specific genes provide potential insights about disease mechanisms, and are strong candidates for further study. Please see Commentary: http://www.biomedcentral.com/1741-7015/9/13/abstract. PMID:21291537

Libraries and Information Science: the Profession. Alternative Career Opportunities for Atmospheric, Earth, and Geo-scientists.

NASA Astrophysics Data System (ADS)

Love, A. M.

2003-12-01

Many graduate students, researchers and scientists may not be aware that there are other career opportunities available to them as scientists besides the traditional academic, government, industrial and private sector tracks. Subject specialists with science backgrounds are in great demand. Knowledge management and information services affiliated with science and research is an exciting and creative profession. Contributing to, finding and delivering the range of information now emerging from new and established disciplines in all formats defines Information Science and Librarianship with a multitude of opportunities. This poster will offer information to encourage students and researchers with these skills and backgrounds to consider Information and Library Science as an exciting career path.

Background factors related to and/or influencing occupation in mentally disordered offenders.

PubMed

Lindstedt, Helena; Ivarsson, Ann-Britt; Söderlund, Anne

2006-09-01

Knowledge of background and occupational related factors of mentally disordered offenders are missing. It is essential to understand these issues when planning discharge from forensic psychiatric hospital care to enable community dwelling. One aim was to investigate mentally disordered offenders' background factors, confidence in and how they value occupations. Another aim was to investigate MDOs background factors' in relation to and the influences on Occupational Performance and Social Participation. Data was collected with an explorative, correlative design after informed consent, from 74 mentally disordered offenders (mean age 34,2) cared for in forensic psychiatric hospitals. Assessments were Allen Cognitive Level Screen, Capability to Perform Daily Occupations, Interview Schedule of Social Interaction, Manchester Short Assessment of Quality of Life, Self-efficacy Scale and Importance scale. Eight background factors were assembled from the individual forensic psychiatric investigation. Most of the investigated background factors relate to and half of them influence occupational performance, particular the cognitive aspect of occupational performance. The influences on occupation originate from adulthood, such as suffering from schizophrenia, psycho/social problems, and having performed violent crimes. These findings indicate that staff in forensic hospital care should initiate rehabilitation with knowledge about MDOs' complex daily occupations. For avoiding information bias, information gathering preceding treatment planning should be performed in collaboration between caring staff and mentally disordered offenders.

The 2014 Sandia Verification and Validation Challenge: Problem statement

DOE PAGES

Hu, Kenneth; Orient, George

2016-01-18

This paper presents a case study in utilizing information from experiments, models, and verification and validation (V&V) to support a decision. It consists of a simple system with data and models provided, plus a safety requirement to assess. The goal is to pose a problem that is flexible enough to allow challengers to demonstrate a variety of approaches, but constrained enough to focus attention on a theme. This was accomplished by providing a good deal of background information in addition to the data, models, and code, but directing the participants' activities with specific deliverables. In this challenge, the theme ismore » how to gather and present evidence about the quality of model predictions, in order to support a decision. This case study formed the basis of the 2014 Sandia V&V Challenge Workshop and this resulting special edition of the ASME Journal of Verification, Validation, and Uncertainty Quantification.« less

Arterial Stiffness in Children: Pediatric Measurement and Considerations

PubMed Central

Savant, Jonathan D.; Furth, Susan L.; Meyers, Kevin E.C.

2014-01-01

Background Arterial stiffness is a natural consequence of aging, accelerated in certain chronic conditions, and predictive of cardiovascular events in adults. Emerging research suggests the importance of arterial stiffness in pediatric populations. Methods There are different indices of arterial stiffness. The present manuscript focuses on carotid-femoral pulse wave velocity and pulse wave analysis, although other methodologies are discussed. Also reviewed are specific measurement considerations for pediatric populations and the literature describing arterial stiffness in children with certain chronic conditions (primary hypertension, obesity, diabetes, chronic kidney disease, hypercholesterolemia, genetic syndromes involving vasculopathy, and solid organ transplant recipients). Conclusions The measurement of arterial stiffness in children is feasible and, under controlled conditions, can give accurate information about the underlying state of the arteries. This potentially adds valuable information about the functionality of the cardiovascular system in children with a variety of chronic diseases well beyond that of the brachial artery blood pressure. PMID:26587447

Activities and Accomplishments of ICAM

NASA Technical Reports Server (NTRS)

Tiwari, S. N.

1997-01-01

A brief historical background on establishing the Institute for Computational and Applied Mechanics (ICAM) is presented and basic goals and objectives are discussed. It is emphasized that the goal of the ICAM has been to develop and maintain a self-sustaining center of excellence in computational methods at Old Dominion University (ODU). Information is provided on funding sources and budget disposition, recent activities and accomplishments, list of graduate students supported on the program, and number of students who received graduate degrees (M.S. as well as Ph.D.). Information is also provided on research coordination with various scientists and engineers, and on different reports specifically written for ICAM. ICAM has been supported, in part, by NASA Langley Research Center through Grant NAG-1-363. This report constitutes the final report for ICAM for the period ending December 1996. The grant has been monitored by the University Affairs Officers at NASA Langley.

Comparison of element-specific capillary chromotography detectors for the identification of heteroatomic species in coal liquids

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mitchell, S.C.; Bartle, K.D.; Holden, K.M.L.

1994-12-31

A series of heteroatom-rich coal and coal-derived liquids have been analysed using gas chromatography (GC) in combination with three different element-selective detectors. Selected chromatograms, including a supercritical extract (Mequinenza lignite) and aromatic fractions isolated from coal tar pitch samples are presented. In each case a series of sulphur- and/or nitrogen-containing compounds have been identified using either flame photometric detection (GC/FID/FPD) or nitrogen-phosphorous detection (GC/FID/NPD) and the information compared with that obtained from a GC coupled to an atomic emission detector (GC-AED). Preliminary results have demonstrated the relative response characteristics of each detector and their respective ability to acquire qualitative andmore » quantitative information in interfering background matrices. Further, due to the unique capabilities of GC-AED, a number of dual heteroatomic (sulphur-oxygen and nitrogen-oxygen) compounds have been identified.« less

Complementary stable carbon isotope ratio and amount of substance measurements in sports anti-doping.

PubMed

Cawley, Adam T; George, Adrian V

2012-12-01

The detection of steroids originating from synthetic precursors against a background of their chemically identical natural analogues has proven to be a significant challenge for doping control laboratories accredited by the World Anti-Doping Agency (WADA). The complementary application of gas chromatography-mass spectrometry (GC-MS) and gas chromatography-combustion-isotope ratio mass spectrometry (GC-C-IRMS) has been demonstrated to provide specific detection of endogenous steroid misuse for improved anti-doping analysis. Markers of synthetically derived steroids are reviewed on the basis of abnormal urinary excretions and low (13)C content. A combinatorial approach is presented for the interpretation of GC-MS and GC-C-IRMS data in the anti-doping context. This methodology can allow all relevant information concerning an individual's metabolism to be assessed in order to make an informed decision with respect to a doping violation. Copyright © 2012 John Wiley & Sons, Ltd.

Consumer attitudes and the governance of food safety.

PubMed

Todt, Oliver; Muñoz, Emilio; González, Marta; Ponce, Gloria; Estévez, Betty

2009-01-01

This paper reports the analysis of a recent study of public perception of food safety governance in Spain, using genetically modified (GM) foods as an indicator. The data make clear that Spanish food consumers are aware of their rights and role in the marketplace. They are critical of current regulatory decision making, which they perceive to be unduly influenced by certain social actors, such as industry. In contrast, consumers demand decisions to be based primarily on scientific opinion, as well as consumer preferences. They want authorities to facilitate informed purchasing decisions, and favor labeling of GM foods mostly on the grounds of their right to know. However, consumers' actual level of knowledge with respect to food technology and food safety remains low. There are several ambivalences as to the real impact of these attitudes on actual consumer behavior (specifically when it comes to organizing themselves or searching out background information).

Enriching semantic knowledge bases for opinion mining in big data applications

PubMed Central

Weichselbraun, A.; Gindl, S.; Scharl, A.

2014-01-01

This paper presents a novel method for contextualizing and enriching large semantic knowledge bases for opinion mining with a focus on Web intelligence platforms and other high-throughput big data applications. The method is not only applicable to traditional sentiment lexicons, but also to more comprehensive, multi-dimensional affective resources such as SenticNet. It comprises the following steps: (i) identify ambiguous sentiment terms, (ii) provide context information extracted from a domain-specific training corpus, and (iii) ground this contextual information to structured background knowledge sources such as ConceptNet and WordNet. A quantitative evaluation shows a significant improvement when using an enriched version of SenticNet for polarity classification. Crowdsourced gold standard data in conjunction with a qualitative evaluation sheds light on the strengths and weaknesses of the concept grounding, and on the quality of the enrichment process. PMID:25431524

Beyond scene gist: Objects guide search more than scene background.

PubMed

Koehler, Kathryn; Eckstein, Miguel P

2017-06-01

Although the facilitation of visual search by contextual information is well established, there is little understanding of the independent contributions of different types of contextual cues in scenes. Here we manipulated 3 types of contextual information: object co-occurrence, multiple object configurations, and background category. We isolated the benefits of each contextual cue to target detectability, its impact on decision bias, confidence, and the guidance of eye movements. We find that object-based information guides eye movements and facilitates perceptual judgments more than scene background. The degree of guidance and facilitation of each contextual cue can be related to its inherent informativeness about the target spatial location as measured by human explicit judgments about likely target locations. Our results improve the understanding of the contributions of distinct contextual scene components to search and suggest that the brain's utilization of cues to guide eye movements is linked to the cue's informativeness about the target's location. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

An Inside Look at School Reform: What We Have Learned about Assessing Student Learning in a Nongraded Primary School.

ERIC Educational Resources Information Center

Hall, Tracey E.; Baker, Scott

This paper provides background information on school reform and describes efforts to implement an assessment system for students with disabilities in 12 nongraded primary classrooms. Background information briefly covers the school restructuring movement, the history of nongraded primary education, alternative assessment strategies which focus on…

Analysis of Naval NETWAR FORCEnet Enterprise: Implications for Capabilities Based Budgeting

DTIC Science & Technology

2006-12-01

of this background information and projecting how ADNS is likely to succeed in the NNFE framework , two fundamental research questions were addressed...background information and projecting how ADNS is likely to succeed in the NNFE framework , two fundamental research questions were addressed. The...Business Approach ......................................................26 Figure 8. Critical Assumption for Common Analytical Framework

76 FR 4478 - Privacy Act of 1974; Report of Modified or Altered System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-25

... contractors that have a need to know the information for the purpose of assisting the Department's efforts to... Records Narrative Statement I. Background and Purpose of the System A. Background The Department of Health... information for the purpose of assisting the Department's efforts to respond to a suspected or confirmed...

76 FR 4476 - Privacy Act of 1974; Report of Modified or Altered System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-25

... contractors that have a need to know the information for the purpose of assisting the Department's efforts to.... Background and Purpose of the System A. Background The Department of Health and Human Services proposes to... Department contractors that have a need to know the information for the purpose of assisting the Department's...

76 FR 4445 - Privacy Act of 1974; Report of Modified or Altered System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-25

... federal agencies and Department contractors that have a need to know the information for the purpose of... of Records Narrative Statement I. Background and Purpose of the System A. Background The Department... and Department contractors that have a need to know the information for the purpose of assisting the...

77 FR 60683 - Proposed Extension of Approval of Information Collection; Comment Request-Safety Standard for...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-04

.... Docket: For access to the docket to read background documents or comments received, go to http://www...: [email protected] . SUPPLEMENTARY INFORMATION: A. Background In 1979, the Commission issued the Safety... based on a test of each product or upon a reasonable testing program. Section 14(b) of the CPSA...

Physical demands, injuries, and conditioning practices of stock car drivers.

PubMed

Ebben, William P; Suchomel, Timothy J

2012-05-01

The purpose of this study was to assess the physical demands, injuries, and conditioning practices of stock car drivers. Forty stock car drivers from 27 states in the United States participated in the interviews for 43.9 ± 13.9 minutes. The interviews examined background information, the physical demands of racing, injuries associated with racing, and the athletic and fitness background and practices of the subjects. Numerical data were analyzed using Pearson's correlation coefficients. Responses to open-ended questions were analyzed using inductive content analysis. Results revealed significant correlation between track points standings and the length of the resistance training sessions (R = -0.71, p = 0.002) and subject self-assessment of their fitness (R = -0.53, p = 0.045). Results also revealed that "upper-body strength" was identified as the most important physical demand. Extreme fatigue was the most common feeling after a demanding race. Subjects reported that shoulder fatigue was the most common form of muscle soreness experienced after a race. Back and torso injuries were the most common injury, although head injuries most frequently required medical attention. The subjects' biggest fear was fire, followed closely by head and neck injury. The bench press and running were the most commonly performed resistance training and cardiovascular exercises, respectively. Subjects reported that their highest motivation for training was to improve their racing performance. Many subjects had athletic backgrounds with football identified as the sport they had most commonly participated in. This study provides additional detailed information. Results of this study can assist strength and conditioning professionals in the development of strength and conditioning programs for performance enhancement and injury prevention that are specific to the needs of this population of athletes.

Adolescents Searching for Health Information on the Internet: An Observational Study

PubMed Central

Derry, Holly A; Resnick, Paul J; Richardson, Caroline R

2003-01-01

Background Adolescents' access to health information on the Internet is partly a function of their ability to search for and find answers to their health-related questions. Adolescents may have unique health and computer literacy needs. Although many surveys, interviews, and focus groups have been utilized to understand the information-seeking and information-retrieval behavior of adolescents looking for health information online, we were unable to locate observations of individual adolescents that have been conducted in this context. Objective This study was designed to understand how adolescents search for health information using the Internet and what implications this may have on access to health information. Methods A convenience sample of 12 students (age 12-17 years) from 1 middle school and 2 high schools in southeast Michigan were provided with 6 health-related questions and asked to look for answers using the Internet. Researchers recorded 68 specific searches using software that captured screen images as well as synchronized audio recordings. Recordings were reviewed later and specific search techniques and strategies were coded. A qualitative review of the verbal communication was also performed. Results Out of 68 observed searches, 47 (69%) were successful in that the adolescent found a correct and useful answer to the health question. The majority of sites that students attempted to access were retrieved directly from search engine results (77%) or a search engine's recommended links (10%); only a small percentage were directly accessed (5%) or linked from another site (7%). The majority (83%) of followed links from search engine results came from the first 9 results. Incorrect spelling (30 of 132 search terms), number of pages visited within a site (ranging from 1-15), and overall search strategy (eg, using a search engine versus directly accessing a site), were each important determinants of success. Qualitative analysis revealed that participants used a trial-and-error approach to formulate search strings, scanned pages randomly instead of systematically, and did not consider the source of the content when searching for health information. Conclusions This study provides a useful snapshot of current adolescent searching patterns. The results have implications for constructing realistic simulations of adolescent search behavior, improving distribution and usefulness of Web sites with health information relevant to adolescents, and enhancing educators' knowledge of what specific pitfalls students are likely to encounter. PMID:14713653

Background frequency of Bacillus species at the Canberra Airport: A 12 month study.

PubMed

Gahan, Michelle E; Thomas, Rory; Rossi, Rebecca; Nelson, Michelle; Roffey, Paul; Richardson, Michelle M; McNevin, Dennis

2015-12-01

Anthrax, caused by Bacillus anthracis, is a naturally occurring disease in Australia. Whilst mainly limited to livestock in grazing regions of Victoria and New South Wales, movement of people, stock and vehicles means B. anthracis could be present outside this region. Of particular interest is the "background" prevalence of B. anthracis at transport hubs including airports. The aim of this study was to determine the background frequency of B. anthracis and the commonly used hoax agent Bacillus thuringiensis at the Canberra Airport over a 12 month period. Samples were collected daily for seven days each month from August 2011-July 2012 and analyzed using species specific real-time polymerase chain reaction. Fourteen samples (of a total of 575) were positive for the B. anthracis PL3 genomic marker, 24 for the cya (pXO1) plasmid marker and five for the capB (pXO2) plasmid marker. Whilst five samples were positive for both PL3 and cya, no samples were positive for all three markers hence there is no evidence to suggest the presence of pathogenic B. anthracis strains. B. anthracis targets were detected primarily in February 2012 and B. thuringiensis peaked in October and November 2011 and again in April and May 2012. This study provides a rapid method to screen for, and differentiate, Bacillus species. Armed with this information investigators will be able to discriminate a "threat" from "background" frequencies should the need arise. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Meeting the ranging of informational needs of chronic low back pain sufferers: conceptual design and rationale of the interactive website ONESELF.

PubMed

Schulz, Peter J; Rubinelli, Sara; Mariotti, Guido; Keller, Nicola

2009-01-01

Information plays an important role in the management and treatment of chronic pain conditions. Often, however, delivered information does not address specific difficulties of consumers. The present study illustrates the design and implementation of the website ONESELF - run by the Institute of Communication and Health of the University of Lugano - which has been created to meet the ranging of informational needs of chronic low back pain sufferers. ONESELF rests on an integrated idea of health literacy that highlights the kind of information consumers need to inform their decisions about back pain. This idea has been tested through a qualitative analysis of requests posted by users in the forum of ONESELF between July 2006 and December 2007. Users seek information to build their declarative (factual) and procedural knowledge, as well as to evaluate that knowledge and apply it to the context of their own life. Online interactional tools such as ONESELF are a promising source of health communication, provided that the content manager of the website and the health professionals collaborate in a rigorously structured manner. ONESELF can benefit traditional medical consultations in helping screen requests from patients that do not need to see a doctor, and in acting as a repository of background information that saves consultation time for more urgent matters.

Site Amplification Characteristics of the Several Seismic Stations at Jeju Island, in Korea, using S-wave Energy, Background Noise, and Coda waves from the East Japan earthquake (Mar. 11th, 2011) Series.

NASA Astrophysics Data System (ADS)

Seong-hwa, Y.; Wee, S.; Kim, J.

2016-12-01

Observed ground motions are composed of 3 main factors such as seismic source, seismic wave attenuation and site amplification. Among them, site amplification is also important factor and should be considered to estimate soil-structure dynamic interaction with more reliability. Though various estimation methods are suggested, this study used the method by Castro et. al.(1997) for estimating site amplification. This method has been extended to background noise, coda waves and S waves recently for estimating site amplification. This study applied the Castro et. al.(1997)'s method to 3 different seismic waves, that is, S-wave Energy, Background Noise, and Coda waves. This study analysed much more than about 200 ground motions (acceleration type) from the East Japan earthquake (March 11th, 2011) Series of seismic stations at Jeju Island (JJU, SGP, HALB, SSP and GOS; Fig. 1), in Korea. The results showed that most of the seismic stations gave similar results among three types of seismic energies. Each station showed its own characteristics of site amplification property in low, high and specific resonance frequency ranges. Comparison of this study to other studies can give us much information about dynamic amplification of domestic sites characteristics and site classification.

Reporting of feasibility factors in publications on integrated treatment programs for women with substance abuse issues and their children: a systematic review and analysis

PubMed Central

2012-01-01

Background Implementation of evidence-based practices in real-world settings is a complex process impacted by many factors, including intervention, dissemination, service provider, and organizational characteristics. Efforts to improve knowledge translation have resulted in greater attention to these factors. Researcher attention to the applicability of findings to applied settings also has increased. Much less attention, however, has been paid to intervention feasibility, an issue important to applied settings. Methods In a systematic review of 121documents regarding integrated treatment programs for women with substance abuse issues and their children, we examined the presence of feasibility-related information. Specifically, we analysed study descriptions for information regarding feasibility factors in six domains (intervention, practitioner, client, service delivery, organizational, and service system). Results On average, fewer than half of the 25 feasibility details assessed were included in the documents. Most documents included some information describing the participating clients, the services offered as part of the intervention, the location of services, and the expected length of stay or number of sessions. Only approximately half of the documents included specific information about the treatment model. Few documents indicated whether the intervention was manualized or whether the intervention was preceded by a standardized screening or assessment process. Very few provided information about the core intervention features versus the features open to local adaptation, or the staff experience or training required to deliver the intervention. Conclusions As has been found in reviews of intervention studies in other fields, our findings revealed that most documents provide some client and intervention information, but few documents provided sufficient information to fully evaluate feasibility. We consider possible explanations for the paucity of feasibility information and provide suggestions for better reporting to promote diffusion of evidence-based practices. PMID:23217025

22 CFR 97.3 - Requirements subject to verification in an outgoing Convention case.

Code of Federal Regulations, 2014 CFR

2014-04-01

... background study. An accredited agency, temporarily accredited agency, or public domestic authority must complete or approve a child background study that includes information about the child's identity, adoptability, background, social environment, family history, medical history (including that of the child's...

22 CFR 97.3 - Requirements subject to verification in an outgoing Convention case.

Code of Federal Regulations, 2012 CFR

2012-04-01

... background study. An accredited agency, temporarily accredited agency, or public domestic authority must complete or approve a child background study that includes information about the child's identity, adoptability, background, social environment, family history, medical history (including that of the child's...

22 CFR 97.3 - Requirements subject to verification in an outgoing Convention case.

Code of Federal Regulations, 2011 CFR

2011-04-01

... background study. An accredited agency, temporarily accredited agency, or public domestic authority must complete or approve a child background study that includes information about the child's identity, adoptability, background, social environment, family history, medical history (including that of the child's...

22 CFR 97.3 - Requirements subject to verification in an outgoing Convention case.

Code of Federal Regulations, 2013 CFR

2013-04-01

... background study. An accredited agency, temporarily accredited agency, or public domestic authority must complete or approve a child background study that includes information about the child's identity, adoptability, background, social environment, family history, medical history (including that of the child's...

22 CFR 97.3 - Requirements subject to verification in an outgoing Convention case.

Code of Federal Regulations, 2010 CFR

2010-04-01

... background study. An accredited agency, temporarily accredited agency, or public domestic authority must complete or approve a child background study that includes information about the child's identity, adoptability, background, social environment, family history, medical history (including that of the child's...

16 CFR § 1102.4 - Scope.

Code of Federal Regulations, 2013 CFR

2013-01-01

... AVAILABLE CONSUMER PRODUCT SAFETY INFORMATION DATABASE Background and Definitions § 1102.4 Scope. This part... Product Safety Information Database, including all information published therein. ...

Diagnosis and mortality in 47,XYY persons: a registry study

PubMed Central

2010-01-01

Background Sex chromosomal abnormalities are relatively common, yet many aspects of these syndromes remain unexplored. For instance epidemiological data in 47,XYY persons are still limited. Methods Using a national Danish registry, we identified 208 persons with 47,XYY or a compatible karyotype, whereof 36 were deceased; all were diagnosed from 1968 to 2008. For further analyses, we identified age matched controls from the male background population (n = 20,078) in Statistics Denmark. We report nationwide prevalence data, data regarding age at diagnosis, as well as total and cause specific mortality data in these persons. Results The average prevalence was 14.2 47,XYY persons per 100,000, which is reduced compared to the expected 98 per 100,000. Their median age at diagnosis was 17.1 years. We found a significantly decreased lifespan from 77.9 years (controls) to 67.5 years (47,XYY persons). Total mortality was significantly increased compared to controls, with a hazard ratio of 3.6 (2.6-5.1). Dividing the causes of deaths according to the International Classification of Diseases, we identified an increased hazard ratio in all informative chapters, with a significantly increased ratio in cancer, pulmonary, neurological and unspecified diseases, and trauma. Conclusion We here present national epidemiological data regarding 47,XYY syndrome, including prevalence and mortality data, showing a significantly delay to diagnosis, reduced life expectancy and an increased total and cause specific mortality. PMID:20509956

Wildlife connectivity approaches and best practices in U.S. state wildlife action plans.

PubMed

Lacher, Iara; Wilkerson, Marit L

2014-02-01

As habitat loss and fragmentation threaten biodiversity on large geographic scales, creating and maintaining connectivity of wildlife populations is an increasingly common conservation objective. To assess the progress and success of large-scale connectivity planning, conservation researchers need a set of plans that cover large geographic areas and can be analyzed as a single data set. The state wildlife action plans (SWAPs) fulfill these requirements. We examined 50 SWAPs to determine the extent to which wildlife connectivity planning, via linkages, is emphasized nationally. We defined linkage as connective land that enables wildlife movement. For our content analysis, we identified and quantified 6 keywords and 7 content criteria that ranged in specificity and were related to linkages for wide-ranging terrestrial vertebrates and examined relations between content criteria and statewide data on focal wide-ranging species, spending, revenue, and conserved land. Our results reflect nationwide disparities in linkage conservation priorities and highlight the continued need for wildlife linkage planning. Only 30% or less of the 50 SWAPs fulfilled highly specific content criteria (e.g., identifying geographic areas for linkage placement or management). We found positive correlations between our content criteria and statewide data on percent conserved land, total focal species, and spending on parks and recreation. We supplemented our content analysis with interviews with 17 conservation professionals to gain specific information about state-specific context and future directions of linkage conservation. Based on our results, relevant literature, and interview responses, we suggest the following best practices for wildlife linkage conservation plans: collect ecologically meaningful background data; be specific; establish community-wide partnerships; and incorporate sociopolitical and socioeconomic information. © 2013 Society for Conservation Biology.

Measurement properties of translated versions of neck-specific questionnaires: a systematic review

PubMed Central

2011-01-01

Background Several disease-specific questionnaires to measure pain and disability in patients with neck pain have been translated. However, a simple translation of the original version doesn't guarantee similar measurement properties. The objective of this study is to critically appraise the quality of the translation process, cross-cultural validation and the measurement properties of translated versions of neck-specific questionnaires. Methods Bibliographic databases were searched for articles concerning the translation or evaluation of the measurement properties of a translated version of a neck-specific questionnaire. The methodological quality of the selected studies and the results of the measurement properties were critically appraised and rated using the COSMIN checklist and criteria for measurement properties. Results The search strategy resulted in a total of 3641 unique hits, of which 27 articles, evaluating 6 different questionnaires in 15 different languages, were included in this study. Generally the methodological quality of the translation process is poor and none of the included studies performed a cross-cultural adaptation. A substantial amount of information regarding the measurement properties of translated versions of the different neck-specific questionnaires is lacking. Moreover, the evidence for the quality of measurement properties of the translated versions is mostly limited or assessed in studies of poor methodological quality. Conclusions Until results from high quality studies are available, we advise to use the Catalan, Dutch, English, Iranian, Korean, Spanish and Turkish version of the NDI, the Chinese version of the NPQ, and the Finnish, German and Italian version of the NPDS. The Greek NDI needs cross-cultural validation and there is no methodologically sound information for the Swedish NDI. For all other languages we advise to translate the original version of the NDI. PMID:21645355

Developing topic-specific search filters for PubMed with click-through data.

PubMed

Li, J; Lu, Z

2013-01-01

Search filters have been developed and demonstrated for better information access to the immense and ever-growing body of publications in the biomedical domain. However, to date the number of filters remains quite limited because the current filter development methods require significant human efforts in manual document review and filter term selection. In this regard, we aim to investigate automatic methods for generating search filters. We present an automated method to develop topic-specific filters on the basis of users' search logs in PubMed. Specifically, for a given topic, we first detect its relevant user queries and then include their corresponding clicked articles to serve as the topic-relevant document set accordingly. Next, we statistically identify informative terms that best represent the topic-relevant document set using a background set composed of topic irrelevant articles. Lastly, the selected representative terms are combined with Boolean operators and evaluated on benchmark datasets to derive the final filter with the best performance. We applied our method to develop filters for four clinical topics: nephrology, diabetes, pregnancy, and depression. For the nephrology filter, our method obtained performance comparable to the state of the art (sensitivity of 91.3%, specificity of 98.7%, precision of 94.6%, and accuracy of 97.2%). Similarly, high-performing results (over 90% in all measures) were obtained for the other three search filters. Based on PubMed click-through data, we successfully developed a high-performance method for generating topic-specific search filters that is significantly more efficient than existing manual methods. All data sets (topic-relevant and irrelevant document sets) used in this study and a demonstration system are publicly available at http://www.ncbi.nlm.nih.gov/CBBresearch/Lu/downloads/CQ_filter/

Developing Topic-Specific Search Filters for PubMed with Click-Through Data

PubMed Central

Li, Jiao; Lu, Zhiyong

2013-01-01

Summary Objectives Search filters have been developed and demonstrated for better information access to the immense and ever-growing body of publications in the biomedical domain. However, to date the number of filters remains quite limited because the current filter development methods require significant human efforts in manual document review and filter term selection. In this regard, we aim to investigate automatic methods for generating search filters. Methods We present an automated method to develop topic-specific filters on the basis of users’ search logs in PubMed. Specifically, for a given topic, we first detect its relevant user queries and then include their corresponding clicked articles to serve as the topic-relevant document set accordingly. Next, we statistically identify informative terms that best represent the topic-relevant document set using a background set composed of topic irrelevant articles. Lastly, the selected representative terms are combined with Boolean operators and evaluated on benchmark datasets to derive the final filter with the best performance. Results We applied our method to develop filters for four clinical topics: nephrology, diabetes, pregnancy, and depression. For the nephrology filter, our method obtained performance comparable to the state of the art (sensitivity of 91.3%, specificity of 98.7%, precision of 94.6%, and accuracy of 97.2%). Similarly, high-performing results (over 90% in all measures) were obtained for the other three search filters. Conclusion Based on PubMed click-through data, we successfully developed a high-performance method for generating topic-specific search filters that is significantly more efficient than existing manual methods. All data sets (topic-relevant and irrelevant document sets) used in this study and a demonstration system are publicly available at http://www.ncbi.nlm.nih.gov/CBBresearch/Lu/downloads/CQ_filter/ PMID:23666447

ISA-TAB-Nano: A Specification for Sharing Nanomaterial Research Data in Spreadsheet-based Format

PubMed Central

2013-01-01

Background and motivation The high-throughput genomics communities have been successfully using standardized spreadsheet-based formats to capture and share data within labs and among public repositories. The nanomedicine community has yet to adopt similar standards to share the diverse and multi-dimensional types of data (including metadata) pertaining to the description and characterization of nanomaterials. Owing to the lack of standardization in representing and sharing nanomaterial data, most of the data currently shared via publications and data resources are incomplete, poorly-integrated, and not suitable for meaningful interpretation and re-use of the data. Specifically, in its current state, data cannot be effectively utilized for the development of predictive models that will inform the rational design of nanomaterials. Results We have developed a specification called ISA-TAB-Nano, which comprises four spreadsheet-based file formats for representing and integrating various types of nanomaterial data. Three file formats (Investigation, Study, and Assay files) have been adapted from the established ISA-TAB specification; while the Material file format was developed de novo to more readily describe the complexity of nanomaterials and associated small molecules. In this paper, we have discussed the main features of each file format and how to use them for sharing nanomaterial descriptions and assay metadata. Conclusion The ISA-TAB-Nano file formats provide a general and flexible framework to record and integrate nanomaterial descriptions, assay data (metadata and endpoint measurements) and protocol information. Like ISA-TAB, ISA-TAB-Nano supports the use of ontology terms to promote standardized descriptions and to facilitate search and integration of the data. The ISA-TAB-Nano specification has been submitted as an ASTM work item to obtain community feedback and to provide a nanotechnology data-sharing standard for public development and adoption. PMID:23311978

Wildlife connectivity approaches and best practices in U.S. state wildlife action plans

USGS Publications Warehouse

Lacher, Iara; Wilkerson, Marit L.

2014-01-01

As habitat loss and fragmentation threaten biodiversity on large geographic scales, creating and maintaining connectivity of wildlife populations is an increasingly common conservation objective. To assess the progress and success of large-scale connectivity planning, conservation researchers need a set of plans that cover large geographic areas and can be analyzed as a single data set. The state wildlife action plans (SWAPs) fulfill these requirements. We examined 50 SWAPs to determine the extent to which wildlife connectivity planning, via linkages, is emphasized nationally. We defined linkage as connective land that enables wildlife movement. For our content analysis, we identified and quantified 6 keywords and 7 content criteria that ranged in specificity and were related to linkages for wide-ranging terrestrial vertebrates and examined relations between content criteria and statewide data on focal wide-ranging species, spending, revenue, and conserved land. Our results reflect nationwide disparities in linkage conservation priorities and highlight the continued need for wildlife linkage planning. Only 30% or less of the 50 SWAPs fulfilled highly specific content criteria (e.g., identifying geographic areas for linkage placement or management). We found positive correlations between our content criteria and statewide data on percent conserved land, total focal species, and spending on parks and recreation. We supplemented our content analysis with interviews with 17 conservation professionals to gain specific information about state-specific context and future directions of linkage conservation. Based on our results, relevant literature, and interview responses, we suggest the following best practices for wildlife linkage conservation plans: collect ecologically meaningful background data; be specific; establish community-wide partnerships; and incorporate sociopolitical and socioeconomic information.

E-Mail Writing: Providing Background Information in the Core of Computer Assisted Instruction

ERIC Educational Resources Information Center

Nazari, Behzad; Ninknejad, Sahar

2015-01-01

The present study highly supported the effective role of providing background information via email by the teacher to write e-mail by the students in learners' writing ability. A total number of 50 EFL advanced male students aged between 25 and 40 at different branches of Iran Language Institute in Tehran, Tehran. Through the placement test of…

Separation of foreground and background from light field using gradient information.

PubMed

Lee, Jae Young; Park, Rae-Hong

2017-02-01

Studies of computer vision or machine vision applications using a light field camera have been increasing in recent years. However, the abilities that the light field camera has are not fully used in these applications. In this paper, we propose a method for direct separation of foreground and background that uses the gradient information and can be used in various applications such as pre-processing. From an optical phenomenon whereby the bundles of rays from the background are flipped, we derive that the disparity sign of the background in the captured three-dimensional scene has the opposite disparity sign of the foreground. Using the majority-weighted voting algorithm based on the gradient information with the Lambertian assumption and the gradient constraint, the foreground and background can be separated at each pixel. In regard to pre-processing, the proposed method can be used for various applications such as occlusion and saliency detection, disparity estimation, and so on. Experimental results with the EPFL light field dataset and Stanford Lytro light field dataset show that the proposed method achieves better performance in terms of the occlusion detection, and thus can be effectively used in pre-processing for saliency detection and disparity estimation.

Background odour induces adaptation and sensitization of olfactory receptors in the antennae of houseflies.

PubMed

Kelling, F J; Ialenti, F; Den Otter, C J

2002-06-01

The presence of background odour was found to have a small but significant effect on the sensitivity of the antennal olfactory system of houseflies, Musca domestica Linnaeus (Diptera: Muscidae), to new pulses of odour. We show that cross-adaptation and cross-sensitization between a background odour of (+/-)-1-octen-3-ol and pulses of (+/-)-1-octen-3-ol, 2-pentanone and R-(+)-limonene can occur, confirming that olfactory receptor cells are sensitive to different odours. Background odour can increase the responses to low concentration odour pulses and decrease the responses to higher concentration odour pulses. It is suggested that background odour has a larger effect on olfactory receptor cells that respond with a tonic increase of spike frequency, giving information about the level of odour concentration, i.e. the 'static' environment. Cells that respond in a phasic way only provide information on the dynamics of the olfactory environment.

A Study on Mutil-Scale Background Error Covariances in 3D-Var Data Assimilation

NASA Astrophysics Data System (ADS)

Zhang, Xubin; Tan, Zhe-Min

2017-04-01

The construction of background error covariances is a key component of three-dimensional variational data assimilation. There are different scale background errors and interactions among them in the numerical weather Prediction. However, the influence of these errors and their interactions cannot be represented in the background error covariances statistics when estimated by the leading methods. So, it is necessary to construct background error covariances influenced by multi-scale interactions among errors. With the NMC method, this article firstly estimates the background error covariances at given model-resolution scales. And then the information of errors whose scales are larger and smaller than the given ones is introduced respectively, using different nesting techniques, to estimate the corresponding covariances. The comparisons of three background error covariances statistics influenced by information of errors at different scales reveal that, the background error variances enhance particularly at large scales and higher levels when introducing the information of larger-scale errors by the lateral boundary condition provided by a lower-resolution model. On the other hand, the variances reduce at medium scales at the higher levels, while those show slight improvement at lower levels in the nested domain, especially at medium and small scales, when introducing the information of smaller-scale errors by nesting a higher-resolution model. In addition, the introduction of information of larger- (smaller-) scale errors leads to larger (smaller) horizontal and vertical correlation scales of background errors. Considering the multivariate correlations, the Ekman coupling increases (decreases) with the information of larger- (smaller-) scale errors included, whereas the geostrophic coupling in free atmosphere weakens in both situations. The three covariances obtained in above work are used in a data assimilation and model forecast system respectively, and then the analysis-forecast cycles for a period of 1 month are conducted. Through the comparison of both analyses and forecasts from this system, it is found that the trends for variation in analysis increments with information of different scale errors introduced are consistent with those for variation in variances and correlations of background errors. In particular, introduction of smaller-scale errors leads to larger amplitude of analysis increments for winds at medium scales at the height of both high- and low- level jet. And analysis increments for both temperature and humidity are greater at the corresponding scales at middle and upper levels under this circumstance. These analysis increments improve the intensity of jet-convection system which includes jets at different levels and coupling between them associated with latent heat release, and these changes in analyses contribute to the better forecasts for winds and temperature in the corresponding areas. When smaller-scale errors are included, analysis increments for humidity enhance significantly at large scales at lower levels to moisten southern analyses. This humidification devotes to correcting dry bias there and eventually improves forecast skill of humidity. Moreover, inclusion of larger- (smaller-) scale errors is beneficial for forecast quality of heavy (light) precipitation at large (small) scales due to the amplification (diminution) of intensity and area in precipitation forecasts but tends to overestimate (underestimate) light (heavy) precipitation .

Development of an acquisition protocol and a segmentation algortihm for wounds of cutaneous Leishmaniasis in digital images

NASA Astrophysics Data System (ADS)

Diaz, Kristians; Castañeda, Benjamín; Miranda, César; Lavarello, Roberto; Llanos, Alejandro

2010-03-01

We developed a protocol for the acquisition of digital images and an algorithm for a color-based automatic segmentation of cutaneous lesions of Leishmaniasis. The protocol for image acquisition provides control over the working environment to manipulate brightness, lighting and undesirable shadows on the injury using indirect lighting. Also, this protocol was used to accurately calculate the area of the lesion expressed in mm2 even in curved surfaces by combining the information from two consecutive images. Different color spaces were analyzed and compared using ROC curves in order to determine the color layer with the highest contrast between the background and the wound. The proposed algorithm is composed of three stages: (1) Location of the wound determined by threshold and mathematical morphology techniques to the H layer of the HSV color space, (2) Determination of the boundaries of the wound by analyzing the color characteristics in the YIQ space based on masks (for the wound and the background) estimated from the first stage, and (3) Refinement of the calculations obtained on the previous stages by using the discrete dynamic contours algorithm. The segmented regions obtained with the algorithm were compared with manual segmentations made by a medical specialist. Broadly speaking, our results support that color provides useful information during segmentation and measurement of wounds of cutaneous Leishmaniasis. Results from ten images showed 99% specificity, 89% sensitivity, and 98% accuracy.

Auditory responses in the amygdala to social vocalizations

NASA Astrophysics Data System (ADS)

Gadziola, Marie A.

The underlying goal of this dissertation is to understand how the amygdala, a brain region involved in establishing the emotional significance of sensory input, contributes to the processing of complex sounds. The general hypothesis is that communication calls of big brown bats (Eptesicus fuscus) transmit relevant information about social context that is reflected in the activity of amygdalar neurons. The first specific aim analyzed social vocalizations emitted under a variety of behavioral contexts, and related vocalizations to an objective measure of internal physiological state by monitoring the heart rate of vocalizing bats. These experiments revealed a complex acoustic communication system among big brown bats in which acoustic cues and call structure signal the emotional state of a sender. The second specific aim characterized the responsiveness of single neurons in the basolateral amygdala to a range of social syllables. Neurons typically respond to the majority of tested syllables, but effectively discriminate among vocalizations by varying the response duration. This novel coding strategy underscores the importance of persistent firing in the general functioning of the amygdala. The third specific aim examined the influence of acoustic context by characterizing both the behavioral and neurophysiological responses to natural vocal sequences. Vocal sequences differentially modify the internal affective state of a listening bat, with lower aggression vocalizations evoking the greatest change in heart rate. Amygdalar neurons employ two different coding strategies: low background neurons respond selectively to very few stimuli, whereas high background neurons respond broadly to stimuli but demonstrate variation in response magnitude and timing. Neurons appear to discriminate the valence of stimuli, with aggression sequences evoking robust population-level responses across all sound levels. Further, vocal sequences show improved discrimination among stimuli compared to isolated syllables, and this improved discrimination is expressed in part by the timing of action potentials. Taken together, these data support the hypothesis that big brown bat social vocalizations transmit relevant information about the social context that is encoded within the discharge pattern of amygdalar neurons ultimately responsible for coordinating appropriate social behaviors. I further propose that vocalization-evoked amygdalar activity will have significant impact on subsequent sensory processing and plasticity.

Feasibility of a patient decision aid regarding disclosure of personal health information: qualitative evaluation of the Health Care Information Directive

PubMed Central

Tracy, C Shawn; Dantas, Guilherme Coelho; Upshur, Ross EG

2004-01-01

Background Concerns regarding the privacy of health information are escalating owing both to the growing use of information technology to store and exchange data and to the increasing demand on the part of patients to control the use of their medical records. The objective of this study was to evaluate the Health Care Information Directive (HCID), a recently-developed patient decision aid that aims to delineate the level of health information an individual is willing to share. Methods We convened a series of four focus group meetings with several communities in a large Canadian city. A total of 28 men and women participated, representing health care consumer advocates, urban professionals, senior citizens, and immigrants who speak English as a second language. Data were analysed using qualitative methods. Results Participants lacked substantial knowledge regarding the fate and uses of personal health information. They expressed mistrust concerning how their information will be used and protected. Several suggestions were made towards customizing the use of data according to specific needs rather than broad and full access to their charts. Furthermore, despite concern regarding the implementation of a tool like the HCID, participants were hopeful that a refined instrument could contribute to the improved regulation of health information. Conclusion This study indicated poor knowledge concerning the uses of personal health information, distrust concerning security provisions, and cautious support for a patient decision aid such as the HCID to improve control over health data. PMID:15361257

Perception on Informed Consent Regarding Nursing Care Practices in a Tertiary Care Center.

PubMed

Paudel, B; Shrestha, G K

Background Consent for care procedures is mandatory after receipt of adequate information. It maintains patient's rights and autonomy to make thoughtful decisions. Poor communication often leads to poor health quality. Objective To assess hospitalized patients' perception on informed consent regarding nursing care practices in a tertiary care center. Method This is a descriptive cross-sectional study among 113 admitted patients conducted in February 2012 at Dhulikhel Hospital, Nepal. Patients of various wards were selected using purposive non-probability sampling with at least 3 days of hospitalization. Close ended structured questionnaire was used to assess patients' perception on three different areas of informed consent (information giving, opportunity to make decision and taking prior consent). Result Among the participants 71.6% perceived positively regarding informed consent towards nursing care practices with a mean score of 3.32 ± 1.28. Patients' perception on various areas of informed consent viz. information giving, opportunities to make specific decision and taking prior consent were all positive with mean values of 3.43±1.12, 2.88±1.23, 3.65±1.49 respectively. Comparison of mean perception of informed consent with various variables revealed insignificant correlation (p-value >0.05) for age, educational level and previous hospitalization while it was significant (p-value < 0.05) for communication skills of nurses. Conclusion Majority of patients have positive perception on informed consent towards nursing care practices. Communication skills of nurses affect the perception of patients' regardless of age, education level and past experiences.

16 CFR 1102.4 - Scope.

Code of Federal Regulations, 2011 CFR

2011-01-01

... CONSUMER PRODUCT SAFETY INFORMATION DATABASE (Eff. Jan. 10, 2011) Background and Definitions § 1102.4 Scope... Available Consumer Product Safety Information Database, including all information published therein. ...

Meta-Generalis: A Novel Method for Structuring Information from Radiology Reports

PubMed Central

Barbosa, Flavio; Traina, Agma Jucci

2016-01-01

Summary Background A structured report for imaging exams aims at increasing the precision in information retrieval and communication between physicians. However, it is more concise than free text and may limit specialists’ descriptions of important findings not covered by pre-defined structures. A computational ontological structure derived from free texts designed by specialists may be a solution for this problem. Therefore, the goal of our study was to develop a methodology for structuring information in radiology reports covering specifications required for the Brazilian Portuguese language, including the terminology to be used. Methods We gathered 1,701 radiological reports of magnetic resonance imaging (MRI) studies of the lumbosacral spine from three different institutions. Techniques of text mining and ontological conceptualization of lexical units extracted were used to structure information. Ten radiologists, specialists in lumbosacral MRI, evaluated the textual superstructure and terminology extracted using an electronic questionnaire. Results The established methodology consists of six steps: 1) collection of radiology reports of a specific MRI examination; 2) textual decomposition; 3) normalization of lexical units; 4) identification of textual superstructures; 5) conceptualization of candidate-terms; and 6) evaluation of superstructures and extracted terminology by experts using an electronic questionnaire. Three different textual superstructures were identified, with terminological variations in the names of their textual categories. The number of candidate-terms conceptualized was 4,183, yielding 727 concepts. There were a total of 13,963 relationships between candidate-terms and concepts and 789 relationships among concepts. Conclusions The proposed methodology allowed structuring information in a more intuitive and practical way. Indications of three textual superstructures, extraction of lexicon units and the normalization and ontologically conceptualization were achieved while maintaining references to their respective categories and free text radiology reports. PMID:27580980

A rigorous approach to facilitate and guarantee the correctness of the genetic testing management in human genome information systems

PubMed Central

2011-01-01

Background Recent medical and biological technology advances have stimulated the development of new testing systems that have been providing huge, varied amounts of molecular and clinical data. Growing data volumes pose significant challenges for information processing systems in research centers. Additionally, the routines of genomics laboratory are typically characterized by high parallelism in testing and constant procedure changes. Results This paper describes a formal approach to address this challenge through the implementation of a genetic testing management system applied to human genome laboratory. We introduced the Human Genome Research Center Information System (CEGH) in Brazil, a system that is able to support constant changes in human genome testing and can provide patients updated results based on the most recent and validated genetic knowledge. Our approach uses a common repository for process planning to ensure reusability, specification, instantiation, monitoring, and execution of processes, which are defined using a relational database and rigorous control flow specifications based on process algebra (ACP). The main difference between our approach and related works is that we were able to join two important aspects: 1) process scalability achieved through relational database implementation, and 2) correctness of processes using process algebra. Furthermore, the software allows end users to define genetic testing without requiring any knowledge about business process notation or process algebra. Conclusions This paper presents the CEGH information system that is a Laboratory Information Management System (LIMS) based on a formal framework to support genetic testing management for Mendelian disorder studies. We have proved the feasibility and showed usability benefits of a rigorous approach that is able to specify, validate, and perform genetic testing using easy end user interfaces. PMID:22369688

Location, Location, Location: Eye-Tracking Evidence that Consumers Preferentially View Prominently Positioned Nutrition Information

PubMed Central

Graham, Dan J.; Jeffery, Robert W.

2012-01-01

Background Nutrition Facts labels can keep consumers better informed about their diets' nutritional composition, however, consumers currently do not understand these labels well or use them often. Thus, modifying existing labels may benefit public health. Objective The present study tracked the visual attention of individuals making simulated food-purchasing decisions to assess Nutrition Facts label viewing. Primary research questions were how self-reported viewing of Nutrition Facts labels and their components relates to measured viewing and whether locations of labels and specific label components relate to viewing. Design The study involved a simulated grocery shopping exercise conducted on a computer equipped with an eye-tracking camera. A post-task survey assessed self-reported nutrition information viewing, health behaviors, and demographics. Subjects/setting Individuals 18 years old and older and capable of reading English words on a computer (n=203) completed the 1-hour protocol at the University of Minnesota during Spring 2010. Statistical analyses Primary analyses included χ2, analysis of variance, and t tests comparing self-reported and measured viewing of label components in different presentation configurations. Results Self-reported viewing of Nutrition Facts label components was higher than objectively measured viewing. Label components at the top of the label were viewed more than those at the bottom, and labels positioned in the center of the screen were viewed more than those located on the sides. Conclusions Nutrition Facts label position within a viewing area and position of specific components on a label relate to viewing. Eye tracking is a valuable technology for evaluating consumers' attention to nutrition information, informing nutrition labeling policy (eg, front-of-pack labels), and designing labels that best support healthy dietary decisions. PMID:22027053

Development of the Primary Care Quality-Homeless (PCQ-H) Instrument: A Practical Survey of Patients' Experiences in Primary Care

PubMed Central

Kertesz, Stefan. G.; Pollio, David E.; Jones, Richard N.; Steward, Jocelyn; Stringfellow, Erin J.; Gordon, Adam J.; Johnson, Nancy K.; Kim, Theresa A.; Granstaff, Unita; Austin, Erika L.; Young, Alexander S.; Golden, Joya; Davis, Lori L.; Roth, David L.; Holt, Cheryl L.

2015-01-01

Background Homeless patients face unique challenges in obtaining primary care responsive to their needs and context. Patient experience questionnaires could permit assessment of patient-centered medical homes for this population, but standard instruments may not reflect homeless patients' priorities and concerns. Objectives This report describes (a) the content and psychometric properties of a new primary care questionnaire for homeless patients and (b) the methods utilized in its development. Methods Starting with quality-related constructs from the Institute of Medicine, we identified relevant themes by interviewing homeless patients and experts in their care. A multidisciplinary team drafted a preliminary set of 78 items. This was administered to homeless-experienced clients (n=563) across 3 VA facilities and 1 non-VA Health Care for the Homeless Program. Using Item Response Theory, we examined Test Information Function curves to eliminate less informative items and devise plausibly distinct subscales. Results The resulting 33-item instrument (Primary Care Quality-Homeless, PCQ-H) has four subscales: Patient-Clinician Relationship (15 items), Cooperation among Clinicians (3 items), Access/Coordination (11 items) and Homeless-Specific Needs (4 items). Evidence for divergent and convergent validity is provided. Test Information Function (TIF) graphs showed adequate informational value to permit inferences about groups for 3 subscales (Relationship, Cooperation and Access/Coordination). The 3-item Cooperation subscale had lower informational value (TIF<5) but had good internal consistency (alpha=0.75) and patients frequently reported problems in this aspect of care. Conclusions Systematic application of qualitative and quantitative methods supported the development of a brief patient-reported questionnaire focused on the primary care of homeless patients and offers guidance for future population-specific instrument development. PMID:25023918

[Dementia in families with a Turkish migration background. Organization and characteristics of domestic care arrangements].

PubMed

Mogar, M; von Kutzleben, M

2015-07-01

Until recently public health and health services research has not been concerned with people suffering from dementia with a Turkish migration background as a priority. There is little evidence about the situation of this population; however, it is known that these individuals almost always live with their families and are cared for by their families generally without seeking professional support. The aim of this study was to gain insight into the organization and characteristics of home-based care arrangements for people suffering from dementia with a Turkish migration background from the family carer's perspective. Interviews with seven family carers. The principles of the grounded theory served as a framework for data analysis. Unconditional commitment to caring for a family member with dementia was identified as the main characteristic of care arrangements in families with a Turkish migration background. Dementia is not a factor that has an impact on the decision of families to assume care responsibility for an affected family member and there is a lack of knowledge about dementia in general. There are various inhibiting factors for the utilization of formal services and the family carers in this sample complained that the available services are not culturally sensitive. There seems to be an extensive need for information and counselling regarding care dependency and dementia among the Turkish community. To provide personal-centred care and relief to these families in the future, efforts should be made to adapt the current care system to the specific needs and demands of this population. Cultural sensitivity in general and individual subjective needs of persons with a Turkish migration background affected by dementia should be taken into account.

The first Malay database toward the ethnic-specific target molecular variation.

PubMed

Halim-Fikri, Hashim; Etemad, Ali; Abdul Latif, Ahmad Zubaidi; Merican, Amir Feisal; Baig, Atif Amin; Annuar, Azlina Ahmad; Ismail, Endom; Salahshourifar, Iman; Liza-Sharmini, Ahmad Tajudin; Ramli, Marini; Shah, Mohamed Irwan; Johan, Muhammad Farid; Hassan, Nik Norliza Nik; Abdul-Aziz, Noraishah Mydin; Mohd Noor, Noor Haslina; Nur-Shafawati, Ab Rajab; Hassan, Rosline; Bahar, Rosnah; Zain, Rosnah Binti; Yusoff, Shafini Mohamed; Yusoff, Surini; Tan, Soon Guan; Thong, Meow-Keong; Wan-Isa, Hatin; Abdullah, Wan Zaidah; Mohamed, Zahurin; Abdul Latiff, Zarina; Zilfalil, Bin Alwi

2015-04-30

The Malaysian Node of the Human Variome Project (MyHVP) is one of the eighteen official Human Variome Project (HVP) country-specific nodes. Since its inception in 9(th) October 2010, MyHVP has attracted the significant number of Malaysian clinicians and researchers to participate and contribute their data to this project. MyHVP also act as the center of coordination for genotypic and phenotypic variation studies of the Malaysian population. A specialized database was developed to store and manage the data based on genetic variations which also associated with health and disease of Malaysian ethnic groups. This ethnic-specific database is called the Malaysian Node of the Human Variome Project database (MyHVPDb). Currently, MyHVPDb provides only information about the genetic variations and mutations found in the Malays. In the near future, it will expand for the other Malaysian ethnics as well. The data sets are specified based on diseases or genetic mutation types which have three main subcategories: Single Nucleotide Polymorphism (SNP), Copy Number Variation (CNV) followed by the mutations which code for the common diseases among Malaysians. MyHVPDb has been open to the local researchers, academicians and students through the registration at the portal of MyHVP ( http://hvpmalaysia.kk.usm.my/mhgvc/index.php?id=register ). This database would be useful for clinicians and researchers who are interested in doing a study on genomics population and genetic diseases in order to obtain up-to-date and accurate information regarding the population-specific variations and also useful for those in countries with similar ethnic background.

Choosing a design to fit the situation: how to improve specificity and positive predictive values using Bayesian lot quality assurance sampling

PubMed Central

Olives, Casey; Pagano, Marcello

2013-01-01

Background Lot Quality Assurance Sampling (LQAS) is a provably useful tool for monitoring health programmes. Although LQAS ensures acceptable Producer and Consumer risks, the literature alleges that the method suffers from poor specificity and positive predictive values (PPVs). We suggest that poor LQAS performance is due, in part, to variation in the true underlying distribution. However, until now the role of the underlying distribution in expected performance has not been adequately examined. Methods We present Bayesian-LQAS (B-LQAS), an approach to incorporating prior information into the choice of the LQAS sample size and decision rule, and explore its properties through a numerical study. Additionally, we analyse vaccination coverage data from UNICEF’s State of the World’s Children in 1968–1989 and 2008 to exemplify the performance of LQAS and B-LQAS. Results Results of our numerical study show that the choice of LQAS sample size and decision rule is sensitive to the distribution of prior information, as well as to individual beliefs about the importance of correct classification. Application of the B-LQAS approach to the UNICEF data improves specificity and PPV in both time periods (1968–1989 and 2008) with minimal reductions in sensitivity and negative predictive value. Conclusions LQAS is shown to be a robust tool that is not necessarily prone to poor specificity and PPV as previously alleged. In situations where prior or historical data are available, B-LQAS can lead to improvements in expected performance. PMID:23378151

Background suppression of infrared small target image based on inter-frame registration

NASA Astrophysics Data System (ADS)

Ye, Xiubo; Xue, Bindang

2018-04-01

We propose a multi-frame background suppression method for remote infrared small target detection. Inter-frame information is necessary when the heavy background clutters make it difficult to distinguish real targets and false alarms. A registration procedure based on points matching in image patches is used to compensate the local deformation of background. Then the target can be separated by background subtraction. Experiments show our method serves as an effective preliminary of target detection.

General Information About Injection Wells

EPA Pesticide Factsheets

This webpage provides general background information on injection wells used to place fluids in the subsurface. It also provides information on use, different categories, and how they are regulated. Information on the protection is also provided.

Low Health Literacy and Evaluation of Online Health Information: A Systematic Review of the Literature

PubMed Central

van den Putte, Bas; Giani, Stefano; van Weert, Julia CM

2015-01-01

Background Recent years have witnessed a dramatic increase in consumer online health information seeking. The quality of online health information, however, remains questionable. The issue of information evaluation has become a hot topic, leading to the development of guidelines and checklists to design high-quality online health information. However, little attention has been devoted to how consumers, in particular people with low health literacy, evaluate online health information. Objective The main aim of this study was to review existing evidence on the association between low health literacy and (1) people’s ability to evaluate online health information, (2) perceived quality of online health information, (3) trust in online health information, and (4) use of evaluation criteria for online health information. Methods Five academic databases (MEDLINE, PsycINFO, Web of Science, CINAHL, and Communication and Mass-media Complete) were systematically searched. We included peer-reviewed publications investigating differences in the evaluation of online information between people with different health literacy levels. Results After abstract and full-text screening, 38 articles were included in the review. Only four studies investigated the specific role of low health literacy in the evaluation of online health information. The other studies examined the association between educational level or other skills-based proxies for health literacy, such as general literacy, and outcomes. Results indicate that low health literacy (and related skills) are negatively related to the ability to evaluate online health information and trust in online health information. Evidence on the association with perceived quality of online health information and use of evaluation criteria is inconclusive. Conclusions The findings indicate that low health literacy (and related skills) play a role in the evaluation of online health information. This topic is therefore worth more scholarly attention. Based on the results of this review, future research in this field should (1) specifically focus on health literacy, (2) devote more attention to the identification of the different criteria people use to evaluate online health information, (3) develop shared definitions and measures for the most commonly used outcomes in the field of evaluation of online health information, and (4) assess the relationship between the different evaluative dimensions and the role played by health literacy in shaping their interplay. PMID:25953147

Making Sense of Mobile- and Web-Based Wellness Information Technology: Cross-Generational Study

PubMed Central

Shankar, Kalpana; Connelly, Kay

2013-01-01

Background A recent trend in personal health and wellness management is the development of computerized applications or information and communication technologies (ICTs) that support behavioral change, aid the management of chronic conditions, or help an individual manage their wellness and engage in a healthier lifestyle. Objective To understand how individuals across 3 generations (young, middle-aged, and older) think about the design and use of collaborative health and wellness management technologies and what roles these could take in their lives. Methods Face-to-face semistructured interviews, paper prototype systems, and video skits were used to assess how individuals from 3 age cohorts (young: 18-25 years; middle-aged: 35-50 years; and older: ≥65 years) conceptualize the role that health and wellness computing could take in their lives. Results A total of 21 participants in the 3 age cohorts took part (young: n=7; middle-aged: n=7; and older: n=7). Young adults expected to be able to actively manage the presentation of their health-related information. Middle-aged adults had more nuanced expectations that reflect their engagement with work and other life activities. Older adults questioned the sharing of health information with a larger audience, although they saw the value in 1-way sharing between family members or providing aggregated information. Conclusions Our findings inform our suggestions for improving the design of future collaborative health and wellness applications that target specific age groups. We recommend that collaborative ICT health applications targeting young adults should integrate with existing social networking sites, whereas those targeting middle-aged and older adults should support small social networks that rely on intimate personal relationships. Systems that target middle-aged adults should support episodic needs, such as time-sensitive, perhaps intermittent, goal setting. They should also have a low barrier to entry, allowing individuals who do not normally engage with the Internet to participate with the application for the specific purposes of health engagement. Collaborative ICT health applications targeting older adults should allow discreet 1-way sharing, and also support sharing of information in aggregate with others’ data. These systems should also provide mechanisms to preselect recipients of different kinds of data, or to easily direct specific information to individuals in real time. PMID:23900035

Quality of online health information about oral contraceptives from Hebrew-language websites

PubMed Central

2012-01-01

Background The Internet is a frequently used source of health information. Adolescents in particular seem to be receptive to online health information (OHI) and often incorporate such information in their decision-making processes. Yet, OHI is often incomplete, inaccurate, or unreliable. This study assessed the quality of Hebrew online (non-user-generated) content on oral contraceptives (OC), with regard to accuracy/completeness, credibility, and usability. Methods Twenty-nine websites in Hebrew, including those of the four Israeli HMOs, were identified and evaluated. The websites were categorized as: HMO, health portal, contraception-specific, promotional-commercial, and life style and women’s health. A set of established content parameters was selected by a family planning expert to assess accuracy/completeness. The Health on the Net Foundation Code of Conduct (HONcode) principles were used to assess the websites’ reliability. Usability was assessed by applying items selected from the Minervation Validation and the University of Michigan’s ′Website Evaluation checklist′ scale. Mean scores, standard deviations (SD), and ranges were calculated for all websites and for category-specific websites. Correlation between dimensions and Inter-rater reliability were also examined. Results The mean score for accuracy/completeness was 50.9% for all websites (SD=30.1%, range 8–100%). Many websites failed to provide complete information, or provided inaccurate information regarding what to do when a pill is missed and when to use back–up methods. The average credibility score for all websites was 70.6% (SD=15.1, range=38=98%). The credibility parameters that were most commonly absent were funding source, authoring, date of content creation and last modification, explicit reference to evidence-based information, and references and citations. The average usability score for all websites was 94.5% (SD=6.9%, range 79–100%). A weak correlation was found between the three quality parameters assessed. Conclusions Wide variation was noted in the quality of Hebrew-language OC websites. HMOs’ websites scored highest on credibility and usability, and contraceptive-specific websites exhibited the greatest accuracy/completeness. The findings highlight the need to establish quality guidelines for health website content, train health care providers in assisting their patients to seek high quality OHI, and strengthen e-health literacy skills among online-information seekers, including perhaps health professionals. PMID:23006798

[The image of general practitioners from the perspective of patients with and without a Turkish migration background - a qualitative study].

PubMed

Uslu, S; Natanzon, I; Joos, S

2014-06-01

In order to improve the medical care of people with migration background, the existing specialties in medical understanding must be taken into account. The aim of this study was to explore the image of general practitioners from the viewpoint of patients and to evaluate possible differences in the perception of patients with and without a Turkish migration background. 5 focus groups with participants with and without migration background were assessed in German language. In addition to a predefined interview guideline, the collage technique was used in order to explore the image of the practitioners through pictures. The content analysis was conducted according to Mayring using the software program ATLAS.ti. The patients revealed a highly positive image about the general practitioners. By means of the collage technique some negative aspects could be identified which were not discussed in the focus groups. Only minimal differences in the opinions of participants with and without Turkish migration background could be observed. These were a strongly negative attribution to the general practitioners with regard to financial aspects by the participants without migration background on the one hand and a rather paternalistic viewpoint by the participants with Turkish migration background on the other hand. Asked about an image change of general practitioners, the overall opinion has changed over the years from doctors being considered to be "powerful" and "unapproachable" to a "normal" level. Major reasons for this image change were attributed to the fact that patients are becoming increasingly informed about medical issues through the internet and the high work pressure of general practitioners. The image of general practitioners in Turkey was perceived more negative as compared to Germany. The image of general practitioners from the perspective of patients is predominantly positive. Altogether, only minor differences in the perception of German speaking patients with and without Turkish migration background could be identified. Therefore, specific ways of proceeding or qualification measures for general practitioners do not seem necessary in this context. © Georg Thieme Verlag KG Stuttgart · New York.

Contribution of spoken language and socio-economic background to adolescents' educational achievement at age 16 years.

PubMed

Spencer, Sarah; Clegg, Judy; Stackhouse, Joy; Rush, Robert

2017-03-01

Well-documented associations exist between socio-economic background and language ability in early childhood, and between educational attainment and language ability in children with clinically referred language impairment. However, very little research has looked at the associations between language ability, educational attainment and socio-economic background during adolescence, particularly in populations without language impairment. To investigate: (1) whether adolescents with higher educational outcomes overall had higher language abilities; and (2) associations between adolescent language ability, socio-economic background and educational outcomes, specifically in relation to Mathematics, English Language and English Literature GCSE grade. A total of 151 participants completed five standardized language assessments measuring vocabulary, comprehension of sentences and spoken paragraphs, and narrative skills and one nonverbal assessment when between 13 and 14 years old. These data were compared with the participants' educational achievement obtained upon leaving secondary education (16 years old). Univariate logistic regressions were employed to identify those language assessments and demographic factors that were associated with achieving a targeted A * -C grade in English Language, English Literature and Mathematics General Certificate of Secondary Education (GCSE) at 16 years. Further logistic regressions were then conducted to examine further the contribution of socio-economic background and spoken language skills in the multivariate models. Vocabulary, comprehension of sentences and spoken paragraphs, and mean length utterance in a narrative task along with socio-economic background contributed to whether participants achieved an A * -C grade in GCSE Mathematics and English Language and English Literature. Nonverbal ability contributed to English Language and Mathematics. The results of multivariate logistic regressions then found that vocabulary skills were particularly relevant to all three GCSE outcomes. Socio-economic background only remained important for English Language, once language assessment scores and demographic information were considered. Language ability, and in particular vocabulary, plays an important role for educational achievement. Results confirm a need for ongoing support for spoken language ability throughout secondary education and a potential role for speech and language therapy provision in the continuing drive to reduce the gap in educational attainment between groups from differing socio-economic backgrounds. © 2016 Royal College of Speech and Language Therapists.

Knowledge translation to fitness trainers: A systematic review

PubMed Central

2010-01-01

Background This study investigates approaches for translating evidence-based knowledge for use by fitness trainers. Specific questions were: Where do fitness trainers get their evidence-based information? What types of interventions are effective for translating evidence-based knowledge for use by fitness trainers? What are the barriers and facilitators to the use of evidence-based information by fitness trainers in their practice? Methods We describe a systematic review of studies about knowledge translation interventions targeting fitness trainers. Fitness trainers were defined as individuals who provide exercise program design and supervision services to the public. Nurses, physicians, physiotherapists, school teachers, athletic trainers, and sport team strength coaches were excluded. Results Of 634 citations, two studies were eligible for inclusion: a survey of 325 registered health fitness professionals (66% response rate) and a qualitative study of 10 fitness instructors. Both studies identified that fitness trainers obtain information from textbooks, networking with colleagues, scientific journals, seminars, and mass media. Fitness trainers holding higher levels of education are reported to use evidence-based information sources such as scientific journals compared to those with lower education levels, who were reported to use mass media sources. The studies identified did not evaluate interventions to translate evidence-based knowledge for fitness trainers and did not explore factors influencing uptake of evidence in their practice. Conclusion Little is known about how fitness trainers obtain and incorporate new evidence-based knowledge into their practice. Further exploration and specific research is needed to better understand how emerging health-fitness evidence can be translated to maximize its use by fitness trainers providing services to the general public. PMID:20398317

Analyzing small data sets using Bayesian estimation: the case of posttraumatic stress symptoms following mechanical ventilation in burn survivors

PubMed Central

van de Schoot, Rens; Broere, Joris J.; Perryck, Koen H.; Zondervan-Zwijnenburg, Mariëlle; van Loey, Nancy E.

2015-01-01

Background The analysis of small data sets in longitudinal studies can lead to power issues and often suffers from biased parameter values. These issues can be solved by using Bayesian estimation in conjunction with informative prior distributions. By means of a simulation study and an empirical example concerning posttraumatic stress symptoms (PTSS) following mechanical ventilation in burn survivors, we demonstrate the advantages and potential pitfalls of using Bayesian estimation. Methods First, we show how to specify prior distributions and by means of a sensitivity analysis we demonstrate how to check the exact influence of the prior (mis-) specification. Thereafter, we show by means of a simulation the situations in which the Bayesian approach outperforms the default, maximum likelihood and approach. Finally, we re-analyze empirical data on burn survivors which provided preliminary evidence of an aversive influence of a period of mechanical ventilation on the course of PTSS following burns. Results Not suprisingly, maximum likelihood estimation showed insufficient coverage as well as power with very small samples. Only when Bayesian analysis, in conjunction with informative priors, was used power increased to acceptable levels. As expected, we showed that the smaller the sample size the more the results rely on the prior specification. Conclusion We show that two issues often encountered during analysis of small samples, power and biased parameters, can be solved by including prior information into Bayesian analysis. We argue that the use of informative priors should always be reported together with a sensitivity analysis. PMID:25765534

Analyzing small data sets using Bayesian estimation: the case of posttraumatic stress symptoms following mechanical ventilation in burn survivors.

PubMed

van de Schoot, Rens; Broere, Joris J; Perryck, Koen H; Zondervan-Zwijnenburg, Mariëlle; van Loey, Nancy E

2015-01-01

Background : The analysis of small data sets in longitudinal studies can lead to power issues and often suffers from biased parameter values. These issues can be solved by using Bayesian estimation in conjunction with informative prior distributions. By means of a simulation study and an empirical example concerning posttraumatic stress symptoms (PTSS) following mechanical ventilation in burn survivors, we demonstrate the advantages and potential pitfalls of using Bayesian estimation. Methods : First, we show how to specify prior distributions and by means of a sensitivity analysis we demonstrate how to check the exact influence of the prior (mis-) specification. Thereafter, we show by means of a simulation the situations in which the Bayesian approach outperforms the default, maximum likelihood and approach. Finally, we re-analyze empirical data on burn survivors which provided preliminary evidence of an aversive influence of a period of mechanical ventilation on the course of PTSS following burns. Results : Not suprisingly, maximum likelihood estimation showed insufficient coverage as well as power with very small samples. Only when Bayesian analysis, in conjunction with informative priors, was used power increased to acceptable levels. As expected, we showed that the smaller the sample size the more the results rely on the prior specification. Conclusion : We show that two issues often encountered during analysis of small samples, power and biased parameters, can be solved by including prior information into Bayesian analysis. We argue that the use of informative priors should always be reported together with a sensitivity analysis.

[Fax Survey to Elucidate the Information Needs of General Practitioners in Lower Saxony Regarding the Topic of Medical Implants].

PubMed

Schaper, M; Berndt, M; Schrimpf, C; Wilhelmi, M; Elff, M; Haverich, A; Wilhelmi, M

2016-12-01

Background: Medial implants help a multitude of patients to gain more health, mobility and thus, quality of life. In collaboration with a still growing expectation of life especially, i.e., within Western industrial countries, this has led to an increasing use of implants over the last years. However, although biomechanical characteristics of modern implant materials have improved considerably, one big challenge still exists - the implant-associated infection. Early diagnostic and therapeutic interventions could clearly mitigate this issue, but are general practitioners sufficiently informed regarding this topic? Material and Methods: In March 2013 and in close cooperation with the Lower Saxony association of general practitioners, we initiated a survey to elucidate the information demands of general practitioners regarding the topic of medical implants. A total of 939 members of the association were contacted via fax and 101 (10.8 %) responded. Based on the obtained data, we then evaluated which topics are most interesting for this group of medical professionals. Results: The survey clearly indicates that general practitioners request more general implant-related data, e.g., type and specification of an implant as well as its location within the individual patient and contact addresses of the implanting hospital, but also want more specific information regarding diagnostic and therapeutic strategies in the case of implant-associated complications. Conclusion: The present article reports in detail on the conducted fax survey and shows some initial strategies as to how the identified challenges might be faced. Georg Thieme Verlag KG Stuttgart · New York.

Dietary Preferences and Nutritional Information Needs Among Career Firefighters in the United States

PubMed Central

Yang, Justin; Farioli, Andrea; Korre, Maria

2015-01-01

Background: Considerable cardiovascular disease and cancer risk among firefighters are attributable to excess adiposity. Robust evidence confirms strong relationships between dietary patterns and the risk of chronic disease. Dietary modification is more likely to be effective when the strategy is appealing and addresses knowledge gaps. Objective: To assess career firefighters' diet practices and information needs, compare the relative appeal of proposed diet plans, and examine how these vary in association with body composition. Methods: Cross-sectional, online survey distributed to members of the International Association of Fire Fighters. Results: Most firefighters do not currently follow any specific dietary plan (71%) and feel that they receive insufficient nutrition information (68%), but most are interested in learning more about healthy eating (75%). When presented with written descriptions of diets without names or labels and asked to rank them in order of preference, firefighters most often rated the Mediterranean diet as their favorite and gave it a more favorable distribution of relative rankings (P<.001) compared to the Paleo, Atkins, Therapeutic Lifestyle Changes, and Esselsteyn Engine 2 (low-fat, strictly plant-based) diets. Obese respondents reported more limited nutritional knowledge (P<.001) and were more likely to feel that they received insufficient nutritional information (P=.021) than participants with normal body weight. Conclusions: Most career firefighters are overweight or obese and do not practice a specific diet; however, 75% want to learn more about healthy eating. Among popular dietary choices, firefighters were most receptive to a Mediterranean diet and least receptive to a strictly plant-based diet. PMID:26331100

Trial Registration at ClinicalTrials.gov between May and October 2005

PubMed Central

Zarin, Deborah A.; Tse, Tony; Ide, Nicholas C.

2006-01-01

BACKGROUND Clinical trial registration allows interested parties to obtain information about ongoing and completed trials, but there are few data indicating the quality of the information provided during the registration process. We used information in the publicly available ClinicalTrials.gov database to describe patterns of trial registration before and after the implementation by journal editors of a new policy requiring registration as a prerequisite for publication. METHODS We reviewed ClinicalTrials.gov records to determine patterns of completion of the “Intervention Name” and “Primary Outcome Measure” data fields for trials registered on May 20 and October 11, 2005, and for trials registered during the interval between these two dates, inclusively. RESULTS During the interval studied, the number of registrations in ClinicalTrials.gov increased by 73 percent from 13,153 to 22,714. The percentage of interventional trials registered by industry with nonspecific Intervention Name entries (attributable to four drug companies) decreased from 10 percent to 2 percent; all other industry and nonindustry records contained specific entries in this field. Of the 2670 studies registered by industry between the two dates, 76 percent provided information in the Primary Outcome Measure field, although these entries varied markedly in their degree of specificity. In the remaining 24 percent of the records, this field was blank. CONCLUSIONS During the summer of 2005, there were large increases in the number of clinical trial registrations. Overall, the data contained in records were more complete in October than they were in May, but there still is room for substantial improvement. PMID:16382064

77 FR 30932 - Approval and Promulgation of Air Quality Implementation Plans; Massachusetts; Regional Haze

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-24

... background for EPA's proposed action? A. The Regional Haze Problem B. Background Information C. Roles of... the background for EPA's proposed action? A. The Regional Haze Problem Regional haze is visibility... distances, even hundreds of kilometers. Therefore, to effectively address the problem of visibility...

Child Care: State Requirements for Background Checks.

ERIC Educational Resources Information Center

Fagnoni, Cynthia

Background checks involve gathering information from state and federal databases to determine if child care providers have a history of child abuse or other criminal convictions that would make them unacceptable for working with children. Background checks include state criminal history checks, state child abuse registry checks, and Federal Bureau…

In-Home Respite Care Program Development. Background. Coordinator's Manual. Training Manual.

ERIC Educational Resources Information Center

Parham, J. D.; And Others

This volume consists of a background discussion, coordinator's manual, and training manual dealing with developing programs for the in-home respite care (IHRC) of the developmentally disabled. Addressed in the background information unit are the nature of developmental disabilities; program variables, planning, and funding; and practical…

14 CFR 91.1051 - Pilot safety background check.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Pilot safety background check. 91.1051... Operations Program Management § 91.1051 Pilot safety background check. Within 90 days of an individual beginning service as a pilot, the program manager must request the following information: (a) FAA records...

77 FR 10508 - Agency Information Collection Activities; Proposed Collection; Comment Request; Background Checks...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-22

... Activities; Proposed Collection; Comment Request; Background Checks for Contractor Employees (Renewal) AGENCY... the electronic docket, go to www.regulations.gov . Title: Background Checks for Contractor Employees... consolidated in 40 CFR part 9. Abstract: The EPA uses contractors to perform services throughout the nation...

77 FR 55843 - Office of Facilities Management and Program Services; Submission for OMB Review; Background...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-11

... of Facilities Management and Program Services; Submission for OMB Review; Background Investigations... collection of personal data for background investigations for child care workers accessing GSA owned and... assumptions and methodology; ways to enhance the quality, utility, and clarity of the information to be...

Physicians’ Outlook on ICD-10-CM/PCS and Its Effect on Their Practice

PubMed Central

Watzlaf, Valerie; Alkarwi, Zahraa; Meyers, Sandy; Sheridan, Patty

2015-01-01

Background The United States is one of the last countries to change from ICD-9-CM to ICD-10-CM/PCS. The compliance date for implementation of ICD-10-CM/PCS is expected to fall on October 1, 2015. Objectives Evaluate physicians’ perceptions on the change from ICD-9-CM to ICD-10-CM/PCS and its effect on their practice, determine how HIM professionals can assist in this transition, and assess what resources are needed to aid in the transition. Results Twenty physicians were asked to participate in one of three focus groups. Twelve physicians (60 percent) agreed to participate. Top concerns included electronic health record software readiness, increase in documentation specificity and time, ability of healthcare professionals to learn a new language, and inadequacy of current training methods and content. Conclusion Physicians expressed that advantages of ICD-10-CM/PCS were effective data analytics and complexity of patient cases with more specific codes. Health information management professionals were touted as needed during the transition to create simple, clear specialty guides and crosswalks as well as education and training tools specific for physicians. PMID:26807074

Parent psychopathology and offspring mental disorders: results from the WHO World Mental Health Surveys

PubMed Central

McLaughlin, Katie A.; Gadermann, Anne M.; Hwang, Irving; Sampson, Nancy A.; Al-Hamzawi, Ali; Andrade, Laura Helena; Angermeyer, Matthias C.; Benjet, Corina; Bromet, Evelyn J.; Bruffaerts, Ronny; Caldas-de-Almeida, José Miguel; de Girolamo, Giovanni; de Graaf, Ron; Florescu, Silvia; Gureje, Oye; Haro, Josep Maria; Hinkov, Hristo Ruskov; Horiguchi, Itsuko; Hu, Chiyi; Karam, Aimee Nasser; Kovess-Masfety, Viviane; Lee, Sing; Murphy, Samuel D.; Nizamie, S. Haque; Posada-Villa, José; Williams, David R.; Kessler, Ronald C.

2012-01-01

Background Associations between specific parent and offspring mental disorders are likely to have been overestimated in studies that have failed to control for parent comorbidity. Aims To examine the associations of parent with respondent disorders. Method Data come from the World Health Organization (WHO) World Mental Health Surveys (n = 51 507). Respondent disorders were assessed with the Composite International Diagnostic Interview and parent disorders with informant-based Family History Research Diagnostic Criteria interviews. Results Although virtually all parent disorders examined (major depressive, generalised anxiety, panic, substance and antisocial behaviour disorders and suicidality) were significantly associated with offspring disorders in multivariate analyses, little specificity was found. Comorbid parent disorders had significant sub-additive associations with offspring disorders. Population-attributable risk proportions for parent disorders were 12.4% across all offspring disorders, generally higher in high- and upper-middle- than low-/lower-middle-income countries, and consistently higher for behaviour (11.0-19.9%) than other (7.1-14.0%) disorders. Conclusions Parent psychopathology is a robust non-specific predictor associated with a substantial proportion of offspring disorders. PMID:22403085

[Recording and data processing of electrical signals of the specific atrioventricular conduction pathways in man].

PubMed

Héron, F; Mialet, G; Schuller, C; Breton, D; Perrin, J; Degeorges, M

1979-01-01

Signals of the electrical activity of the specific atrioventricular conduction pathways were recorded with an unipolar lead to obtain an exact time reference. The amplifier used had special characteristics: high gain settings (up to 300,000), very low noise levels, and wide filter range (2 Hz - 1,600 Hz). The low amplitude of the signals under study, of the order of a microvolt, and the wide filter range of the amplifier necessitated placing the patient in a Faraday cage. The signals recorded on magnetic tape were treated by a system of analysis for signal treatment. The method of averaging was used to extract the signal from background noise especially that arising from somatic muscle. The amplitude of the Hisian signal was much larger than that usually obtained with other methods. The intervals were determined with precision of the order of 1 millisecond. Frequential analysis of the signals gave another representation of the information contained in the time signals. This new representation seems to give better discrimination of the different zones of activation of the specific atrioventricular conduction pathways.

Unified treatment algorithm for the management of crotaline snakebite in the United States: results of an evidence-informed consensus workshop

PubMed Central

2011-01-01

Background Envenomation by crotaline snakes (rattlesnake, cottonmouth, copperhead) is a complex, potentially lethal condition affecting thousands of people in the United States each year. Treatment of crotaline envenomation is not standardized, and significant variation in practice exists. Methods A geographically diverse panel of experts was convened for the purpose of deriving an evidence-informed unified treatment algorithm. Research staff analyzed the extant medical literature and performed targeted analyses of existing databases to inform specific clinical decisions. A trained external facilitator used modified Delphi and structured consensus methodology to achieve consensus on the final treatment algorithm. Results A unified treatment algorithm was produced and endorsed by all nine expert panel members. This algorithm provides guidance about clinical and laboratory observations, indications for and dosing of antivenom, adjunctive therapies, post-stabilization care, and management of complications from envenomation and therapy. Conclusions Clinical manifestations and ideal treatment of crotaline snakebite differ greatly, and can result in severe complications. Using a modified Delphi method, we provide evidence-informed treatment guidelines in an attempt to reduce variation in care and possibly improve clinical outcomes. PMID:21291549

Improving Imperfect Data from Health Management Information Systems in Africa Using Space–Time Geostatistics

PubMed Central

Gething, Peter W; Noor, Abdisalan M; Gikandi, Priscilla W; Ogara, Esther A. A; Hay, Simon I; Nixon, Mark S; Snow, Robert W; Atkinson, Peter M

2006-01-01

Background Reliable and timely information on disease-specific treatment burdens within a health system is critical for the planning and monitoring of service provision. Health management information systems (HMIS) exist to address this need at national scales across Africa but are failing to deliver adequate data because of widespread underreporting by health facilities. Faced with this inadequacy, vital public health decisions often rely on crudely adjusted regional and national estimates of treatment burdens. Methods and Findings This study has taken the example of presumed malaria in outpatients within the largely incomplete Kenyan HMIS database and has defined a geostatistical modelling framework that can predict values for all data that are missing through space and time. The resulting complete set can then be used to define treatment burdens for presumed malaria at any level of spatial and temporal aggregation. Validation of the model has shown that these burdens are quantified to an acceptable level of accuracy at the district, provincial, and national scale. Conclusions The modelling framework presented here provides, to our knowledge for the first time, reliable information from imperfect HMIS data to support evidence-based decision-making at national and sub-national levels. PMID:16719557