Nuclear deterrence in the Arab-Israeli conflict. A case study in Egyptian-Israeli relations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shikaki, K.I.

1986-01-01

In order to achieve security and stability, and maximize the chances for resolving the Arab-Israeli conflict, should Egypt and Israel adopt declared nuclear deterrence doctrines. Or would such a move be ineffective, dangerous, or even disastrous. The nuclearization of the Middle East is not necessary: military threats to the survival of the states in the region do not justify the introduction of nuclear weapons. Nuclearization is not desirable: deterrence theory's assumptions and implications exhibit intellectual weakness and its explanatory power is unsatisfactory; nuclear deterrence may reduce the frequency of war, but it pays little attention to the consequences of war;more » and in comparison to defense, nuclear deterrence may lack credibility. Presently, Israel has nuclear capability and delivery systems sufficient to provide security to its vital areas through deterrence of or defense against Arab attacks. The Arabs do not, however, believe that such security extends to the Arab territories occupied by Israel during the June 1967 war. To supply security, nuclear deterrence must be effective, stable, and credible. In a multinuclear environment, the Egyptians and Israelis are likely to meet the requirement for an effective deterrence: the possession of a nuclear capability sufficient to inflict an enormous amount of death and destruction. If the Arabs and Israelis sought and adopted strategies of deterrence, they might be able to meet the requirement for a stable deterrence: the acquisition of second strike capabilities.« less

Can We Control Cheating in the Classroom?

ERIC Educational Resources Information Center

Kerkvliet, Joe; Sigmund, Charles L.

1999-01-01

Examines the determinants of class-specific academic cheating on examinations, class-to-class differences in the severity of the cheating problem across 12 principles of economics classes, whether control measures are effective, and the relative effectiveness of deterrent measures. Considers methods for gathering data on cheating. (CMK)

Deterrence Theory and the Role of Shame in Projected Offending of College Students against a Ban on Alcohol

ERIC Educational Resources Information Center

Kelley, Margaret S.; Fukushima, Miyuki; Spivak, Andrew L.; Payne, David

2009-01-01

In the present study we advance previous research in deterrence theory by examining the perceived deterrent effects of a newly instituted dry policy on a college campus. A survey of 500 full-time undergraduate students between the ages of 18 and 26 was conducted 3 months following the ban on alcohol. Hypotheses are derived from deterrence theory…

ASSESSING THE UNCERTAINTY OF NUCLEAR DETERRENCE

DTIC Science & Technology

2017-04-22

empirical attempts. From both qualitative and quantitative perspectives, this paper finds cause to question the certainty that nuclear deterrence will...suggests nuclear weapons do indeed possess a higher deterrence effect than conventional forces alone. Data from the “ Correlates of War” data set was...certainly do not provide an absolute deterrent against aggression. 16 While nuclear weapons appear to be correlated with a reduction in the occurrences

The transition to a deterrence posture more reliant on strategic defenses

NASA Astrophysics Data System (ADS)

Chrzanowski, Paul L.

1988-12-01

Strategic nuclear deterrence is currently based on the overwhelming capability of the arsenals of the two superpowers. Massive damage would be inflicted upon the military forces and industrial capacity of both sides should nuclear war occur and escalation of conflict not be controlled. Nuclear deterrence has fostered a condition of peace in central Europe and an absence of direct conflict between the U.S. and the Soviet Union. However, some question whether deterrence will remain effective into the indefinite future, and should deterrence fail the consequences are grave.

Affect intensity and processing fluency of deterrents.

PubMed

Holman, Andrei

2013-01-01

The theory of emotional intensity (Brehm, 1999) suggests that the intensity of affective states depends on the magnitude of their current deterrents. Our study investigated the role that fluency--the subjective experience of ease of information processing--plays in the emotional intensity modulations as reactions to deterrents. Following an induction phase of good mood, we manipulated both the magnitude of deterrents (using sets of photographs with pre-tested potential to instigate an emotion incompatible with the pre-existent affective state--pity) and their processing fluency (normal vs. enhanced through subliminal priming). Current affective state and perception of deterrents were then measured. In the normal processing conditions, the results revealed the cubic effect predicted by the emotional intensity theory, with the initial affective state being replaced by the one appropriate to the deterrent only in participants exposed to the high magnitude deterrence. In the enhanced fluency conditions the emotional intensity pattern was drastically altered; also, the replacement of the initial affective state occurred at a lower level of deterrence magnitude (moderate instead of high), suggesting the strengthening of deterrence emotional impact by enhanced fluency.

An evaluation of the specific deterrent effect of vehicle impoundment on suspended, revoked and unlicensed drivers in California

DOT National Transportation Integrated Search

1997-11-01

While license suspension has been shown to be effective, many drivers with suspended (S) or revoked (R) licenses continue to drive illegally, collecting additional citations and becoming involved in crashes. To reduce the occurrence of driving by off...

Mitigating the Impact of Bats in Historic Churches: The Response of Natterer’s Bats Myotis nattereri to Artificial Roosts and Deterrence

PubMed Central

Zeale, Matt R. K.; Bennitt, Emily; Newson, Stuart E.; Packman, Charlotte; Browne, William J.; Harris, Stephen; Jones, Gareth; Stone, Emma

2016-01-01

Bats frequently roost in historic churches, and these colonies are of considerable conservation value. Inside churches, bat droppings and urine can cause damage to the historic fabric of the building and to items of cultural significance. In extreme cases, large quantities of droppings can restrict the use of a church for worship and/or other community functions. In the United Kingdom, bats and their roosts are protected by law, and striking a balance between conserving the natural and cultural heritage can be a significant challenge. We investigated mitigation strategies that could be employed in churches and other historic buildings to alleviate problems caused by bats without adversely affecting their welfare or conservation status. We used a combination of artificial roost provision and deterrence at churches in Norfolk, England, where significant maternity colonies of Natterer’s bats Myotis nattereri damage church features. Radio-tracking data and population modelling showed that excluding M. nattereri from churches is likely to have a negative impact on their welfare and conservation status, but that judicious use of deterrents, especially high intensity ultrasound, can mitigate problems caused by bats. We show that deterrence can be used to move bats humanely from specific roosting sites within a church and limit the spread of droppings and urine so that problems to congregations and damage to cultural heritage can be much reduced. In addition, construction of bespoke roost spaces within churches can allow bats to continue to roost within the fabric of the building without flying in the church interior. We highlight that deterrence has the potential to cause serious harm to M. nattereri populations if not used judiciously, and so the effects of deterrents will need careful monitoring, and their use needs strict regulation. PMID:26771548

The Common Sense of Small Nuclear Arsenals

DTIC Science & Technology

2012-01-01

affairs. That pattern is continuing and, therefore, is worth examining. In this article I use structural theory to explain what I call “the com­ mon...deterrence and dis­ suasion and then explain small nuclear arsenals in terms of structural theory , relying most heavily on the effects of socialization...deterrence are particularly useful. Dissuasion and general deterrence share many common elements. Both are rooted in deterrence theory and share an

An evaluation of the elimination of plea bargaining for DWI offenders

DOT National Transportation Integrated Search

1989-01-01

The purpose of the evaluation was to determine the effects of eliminating plea bargaining for DWI offenses on general deterrence, recidivism, and court operations were studied. Specific indicators of impact on these three areas were identified and me...

Active Travel Behavior in a Border Region of Texas and New Mexico: Motivators, Deterrents, and Characteristics.

PubMed

Sener, Ipek N; Lee, Richard J

2017-08-01

Active travel has been linked with improved transportation and health outcomes, such as reduced traffic congestion and air pollution, improved mobility, accessibility, and equity, and increased physical and mental health. The purpose of this study was to better understand active travel characteristics, motivators, and deterrents in the El Paso, TX, region. A multimodal transportation survey brought together elements of transportation and health, with a focus on attitudinal characteristics. The analysis consisted of an initial descriptive analysis, spatial analysis, and multivariate binary and ordered-response models of walking and bicycling behavior. The motivators and deterrents of active travel differed for walkers, bicyclists, and noncyclists interested in bicycling. The link between active travel and life satisfaction was moderated by age, with a negative association for older travelers. This effect was stronger for bicycling than it was for walking. Based on the findings, several interventions to encourage walking and bicycling were suggested. These included infrastructure and built environment enhancements, workplace programs, and interventions targeting specific subpopulations.

Identification of the mosquito biting deterrent constituents from the Indian folk remedy plant Jatropha curcas

USDA-ARS?s Scientific Manuscript database

An investigation of the Indian folk remedy plant, Jatropha curcas, was performed to specifically identify the constituents responsible for the mosquito biting deterrent activity of the oil as a whole. Jatropha curcas seed oil is burned in oil lamps in India and part of Africa to repel biting insect...

The Relative Effectiveness of Various Incentives and Deterrents as Judged by Pupils and Teachers.

ERIC Educational Resources Information Center

Burns, Robert B.

1978-01-01

Compares opinions of British teachers and students toward educational incentives and deterrents. Little change has occurred in the responses of teachers and students over the 24 years. Differences of opinion are evident between pupils and teachers, especially with regard to corporal punishment as a deterrent and adult approval as an incentive.…

How Close is too Close? The Effect of a Non-Lethal Electric Shark Deterrent on White Shark Behaviour.

PubMed

Kempster, Ryan M; Egeberg, Channing A; Hart, Nathan S; Ryan, Laura; Chapuis, Lucille; Kerr, Caroline C; Schmidt, Carl; Huveneers, Charlie; Gennari, Enrico; Yopak, Kara E; Meeuwig, Jessica J; Collin, Shaun P

2016-01-01

Sharks play a vital role in the health of marine ecosystems, but the potential threat that sharks pose to humans is a reminder of our vulnerability when entering the ocean. Personal shark deterrents are being marketed as the solution to mitigate the threat that sharks pose. However, the effectiveness claims of many personal deterrents are based on our knowledge of shark sensory biology rather than robust testing of the devices themselves, as most have not been subjected to independent scientific studies. Therefore, there is a clear need for thorough testing of commercially available shark deterrents to provide the public with recommendations of their effectiveness. Using a modified stereo-camera system, we quantified behavioural interactions between white sharks (Carcharodon carcharias) and a baited target in the presence of a commercially available, personal electric shark deterrent (Shark Shield Freedom7™). The stereo-camera system enabled an accurate assessment of the behavioural responses of C. carcharias when encountering a non-lethal electric field many times stronger than what they would naturally experience. Upon their first observed encounter, all C. carcharias were repelled at a mean (± std. error) proximity of 131 (± 10.3) cm, which corresponded to a mean voltage gradient of 9.7 (± 0.9) V/m. With each subsequent encounter, their proximity decreased by an average of 11.6 cm, which corresponded to an increase in tolerance to the electric field by an average of 2.6 (± 0.5) V/m per encounter. Despite the increase in tolerance, sharks continued to be deterred from interacting for the duration of each trial when in the presence of an active Shark Shield™. Furthermore, the findings provide no support to the theory that electric deterrents attract sharks. The results of this study provide quantitative evidence of the effectiveness of a non-lethal electric shark deterrent, its influence on the behaviour of C. carcharias, and an accurate method for testing other shark deterrent technologies.

How Close is too Close? The Effect of a Non-Lethal Electric Shark Deterrent on White Shark Behaviour

PubMed Central

Hart, Nathan S.; Ryan, Laura; Chapuis, Lucille; Kerr, Caroline C.; Schmidt, Carl; Huveneers, Charlie; Gennari, Enrico; Yopak, Kara E.; Meeuwig, Jessica J.; Collin, Shaun P.

2016-01-01

Sharks play a vital role in the health of marine ecosystems, but the potential threat that sharks pose to humans is a reminder of our vulnerability when entering the ocean. Personal shark deterrents are being marketed as the solution to mitigate the threat that sharks pose. However, the effectiveness claims of many personal deterrents are based on our knowledge of shark sensory biology rather than robust testing of the devices themselves, as most have not been subjected to independent scientific studies. Therefore, there is a clear need for thorough testing of commercially available shark deterrents to provide the public with recommendations of their effectiveness. Using a modified stereo-camera system, we quantified behavioural interactions between white sharks (Carcharodon carcharias) and a baited target in the presence of a commercially available, personal electric shark deterrent (Shark Shield Freedom7™). The stereo-camera system enabled an accurate assessment of the behavioural responses of C. carcharias when encountering a non-lethal electric field many times stronger than what they would naturally experience. Upon their first observed encounter, all C. carcharias were repelled at a mean (± std. error) proximity of 131 (± 10.3) cm, which corresponded to a mean voltage gradient of 9.7 (± 0.9) V/m. With each subsequent encounter, their proximity decreased by an average of 11.6 cm, which corresponded to an increase in tolerance to the electric field by an average of 2.6 (± 0.5) V/m per encounter. Despite the increase in tolerance, sharks continued to be deterred from interacting for the duration of each trial when in the presence of an active Shark Shield™. Furthermore, the findings provide no support to the theory that electric deterrents attract sharks. The results of this study provide quantitative evidence of the effectiveness of a non-lethal electric shark deterrent, its influence on the behaviour of C. carcharias, and an accurate method for testing other shark deterrent technologies. PMID:27368059

Effect of qualitative and quantitative variation in allelochemicals on a generalist insect: Iridoid glycosides and the southern armyworm.

PubMed

Puttick, G M; Bowers, M D

1988-01-01

The behavioral and physiological effects of plant allelochemicals have been difficult to demonstrate; it is not often clear whether the compounds are deterrent, toxic, or both. In this study, we compared the qualitative and quantitative effects of several iridoid glycosides on a generalist lepidopteran herbivore,Spodoptera eridania (Noctuidae). Larval growth and survivorship and larval preference or avoidance were measured on artificial diets containing different iridoid glycosides at different concentrations. We also tested the toxicity/deterrence of these compounds. We found that iridoid glycosides retarded larval growth significantly at relatively low concentrations and that they were usually avoided in preference tests. The toxicity/ deterrence test did not always reflect the results of these other tests. The merits of using a variety of methods for determining deterrence and/or toxicity of plant allelochemicals are discussed.

Why Do Blood Donors Lapse or Reduce Their Donation's Frequency?

PubMed

Charbonneau, Johanne; Cloutier, Marie-Soleil; Carrier, Élianne

2016-01-01

Finding effective ways to retain blood donors is crucial. This study seeks to compare, in a context of a voluntary and nonremunerated system, donor demographics and deterrents to blood donation among plasma/platelet donors (PPDs), regular whole blood donors (WBDs), and lapsed whole blood donors (LWBD). Among 1879 participants to a survey on motivations, time use, and blood donation, 207 WBDs (26%) and 148 PPDs (31%) said that they reduced their donation frequency over the last 5 years. Participants to this survey also included 609 LWBDs, who did not donate in the past 5 years. We asked about reasons why they reduce or cease to donate blood and demographic variables. χ(2) Tests were completed to determine which deterrents stand out across the 3 blood donor groups. The deterrent indicating the highest percentage was "time constraints related to work or studies" (43% for all respondents). Comparison of WBDs, LWBDs, and PPDs shows that results for 7 deterrents were statistically different between the 3 groups. Obstacles to donating blood also vary based on sex, age (life course), and level of education. Blood collection agencies should consider developing new retention strategies tailored to blood donors, taking into account the specific profiles of female/male donors, events that typically occur at various stages of life, and particular challenges associated with differences in levels of education. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

Habituation in Frankliniella occidentalis to deterrent plant compounds and their blends.

PubMed

Egger, Barbara; Spangl, Bernhard; Koschier, Elisabeth Helene

2014-06-01

Feeding and oviposition deterrence of three secondary plant compounds and their 1:1 blends to adult female Frankliniella occidentalis Pergande (Thysanoptera: Thripidae) and the potential for habituation of the thrips to the pure compounds and the 1:1 blends at various concentrations were investigated. In choice assays, we tested dose-dependent feeding and oviposition deterrence of the two fatty acid derivatives methyl jasmonate and cis -jasmone, the phenylpropanoid allylanisole, and their blends when directly applied to bean leaf discs. The concentration required to reduce the feeding damage by 50% relative to the control treatment (FDC 50 ) was lowest for cis -jasmone and highest for allylanisole. The feeding deterrent effect of both jasmonates was increased when blended with allylanisole. Feeding deterrence and oviposition deterrence were strongly correlated. In no-choice assays conducted over four consecutive days, we discovered that dilutions at low concentrations (FDC 15 ) applied to bean leaves resulted in habituation to the deterrents, whereas no habituation occurred at higher concentrations (FDC 50 ). We observed a tendency that the 1:1 blends reduce the probability that thrips habituate to the deterrent compounds. Our results may be useful in the development of integrated crop protection strategies with the implementation of allelochemicals as pest behaviour-modifying agents.

Minimum Nuclear Deterrence Research

DTIC Science & Technology

2003-05-15

well as by additional experts interviewed in Paris (November 2002). One expert at the French MoD stressed the psychological importance of the 1940...continued to stress France’s commitment to "contributing to European security" specifically through the existence of its nuclear deterrent.43...Mondiale (Thesis, Paris, Librairie Générale de Droit et de Jurisprudence, 1966, p. 441) as cited in David Cumin , L’Arme

Abuse-deterrent formulations approval reform: Will clinical correctness or real-world results be used to address the nation's opioid crisis: "Noninterference" as a new approval standard.

PubMed

Cohen, Dan

To further the public policy objectives of Congress and the country, legislators should now insist that abuse-deterrent formulations (ADFs) be deployed for every C-II opioid and stimulant. The need for these innovative technologies has never been greater. And to most efficiently incentivize innovators to develop and deploy the most effective and modern deterrents, a new and simpler regulatory approval standard for ADF should be adopted by the U.S. Food and Drug Administration. That standard, based on a concept of "Noninterference" increases the potential for a much earlier deployment of ADFs in a broad range of products and allows deterrence to play its most effective role in combatting the national opioid crisis.

(E)-Caryophyllene and α-Humulene: Aedes aegypti Oviposition Deterrents Elucidated by Gas Chromatography-Electrophysiological Assay of Commiphora leptophloeos Leaf Oil

PubMed Central

da Silva, Rayane Cristine Santos; Milet-Pinheiro, Paulo; Bezerra da Silva, Patrícia Cristina; da Silva, Alexandre Gomes; da Silva, Marcia Vanusa; Navarro, Daniela Maria do Amaral Ferraz; da Silva, Nicácio Henrique

2015-01-01

Aedes aegypti is responsible for the transmission of dengue, a disease that infects millions of people each year. Although essential oils are well recognized as sources of compounds with repellent and larvicidal activities against the dengue mosquito, much less is known about their oviposition deterrent effects. Commiphora leptophloeos, a tree native to South America, has important pharmacological properties, but the chemical profile and applicability of its essential oil in controlling the spread of the dengue mosquito have not been investigated. The aim of this study was to determine the composition of C. leptophloeos leaf oil and to evaluate its larvicidal and oviposition deterrent effects against A. aegypti. Fifty-five components of the essential oil were detected by gas chromatography (GC)—mass spectrometry, with α-phellandrene (26.3%), (E)-caryophyllene (18.0%) and β-phellandrene (12.9%) identified as the major constituents. Bioassays showed that the oil exhibited strong oviposition deterrent effects against A. aegypti at concentrations between 25 and 100 ppm, and possessed good larvicidal activity (LC50 = 99.4 ppm). Analysis of the oil by GC coupled with electroantennographic detection established that seven constituents could trigger antennal depolarization in A. aegypti gravid females. Two of these components, namely (E)-caryophyllene and α-humulene, were present in substantial proportions in the oil, and oviposition deterrence assays confirmed that both were significantly active at concentrations equivalent to those present in the oil. It is concluded that these sesquiterpenes are responsible, at least in part, for the deterrent effect of the oil. The oviposition deterrent activity of the leaf oil of C. leptophloeos is one of the most potent reported so far, suggesting that it could represent an interesting alternative to synthetic insecticides. The results of this study highlight the importance of integrating chemical and electrophysiological methods for screening natural compounds for their potential in combating vectors of insect-borne diseases. PMID:26650757

Unconventional Deterrence Strategy

DTIC Science & Technology

2005-06-01

200 words) This thesis examines a largely unexplored area of deterrence theory – unconventional deterrence. Unconventional deterrence is defined...hypothesis of deterrence theory which says that the balance of the opponents’ military capabilities is the basic determinant of successful deterrence...

From Power Projection To Power Protection: Revitalizing Conventional Deterrence In NATO

DTIC Science & Technology

2016-06-01

deterrence, in its broadest sense, means persuading an opponent not to initiate a specific action because the perceived benefits do not justify...relies on an extended calculation of adversary costs and benefits . A calculation for denial must only look at the respective forces for that particular...force to a forward deployment of an infantry company. A significant benefit of power projection is that it allows husbanding of resources at home or at

Preventing youth access to alcohol: outcomes from a multi-community time-series trial*.

PubMed

Wagenaar, Alexander C; Toomey, Traci L; Erickson, Darin J

2005-03-01

AIMS/INTERVENTION: The Complying with the Minimum Drinking Age project (CMDA) is a community trial designed to test effects of two interventions designed to reduce alcohol sales to minors: (1) training for management of retail alcohol establishments and (2) enforcement checks of alcohol establishments. CMDA is a multi-community time-series quasi-experimental trial with a nested cohort design. CMDA was implemented in 20 cities in four geographic areas in the US Midwest. The core outcome, propensity for alcohol sales to minors, was directly tested with research staff who attempted to purchase alcohol without showing age identification using a standardized protocol in 602 on-premise and 340 off-premise alcohol establishments. Data were collected every other week in all communities over 4 years. Mixed-model regression and Box-Jenkins time-series analyses were used to assess short- and long-term establishment-specific and general community-level effects of the two interventions. Effects of the training intervention were mixed. Specific deterrent effects were observed for enforcement checks, with an immediate 17% reduction in likelihood of sales to minors. These effects decayed entirely within 3 months in off-premise establishments and to an 8.2% reduction in on-premise establishments. Enforcement checks prevent alcohol sales to minors. At the intensity levels tested, enforcement primarily affected specific establishments checked, with limited diffusion to the whole community. Finally, most of the enforcement effect decayed within 3 months, suggesting that a regular schedule of enforcement is necessary to maintain deterrence.

Little Boy to Star Wars the evolution of American deterrence. Research report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Havey, M.E.

1986-05-01

The historical and sociological development of the American deterrent posture in the nuclear age is traced since the its dawn at Alamagordo, New Mexico, 16 July 1945, and the use of the Little Boy over Hiroshima three weeks later. A description of Western man's involvement in and reaction to pre-1945 catastrophic circumstances is followed by a comparative examination of the post-1945 changes in national policy in regard to the use and dangers of total war. Using Bernard Brodie as a theoretical deterrent baseline, the author analyzes the ethical and military shifts in U.S. declaratory (versus actual) nuclear policy, through Paulmore » Nitze's statements of future policy in light of strategic defense. The author concludes that extremely effective--not necessarily perfect--defenses can be based dramatically on the beneficial effects of arms control. But at the same time, such a condition must inevitably result in a de facto reversion of U.S. nuclear policy to that of a small, non-counterforce force de frappe deterrent - similar in effect to that of the present French posture. The implications of this upon U.S.-Soviet force balance, the historical trends of the American Way of War, and the present deterrent mindset of the officer corps is left as a grave concern.« less

The Effect of Suspension as a Deterrent to Student Misconduct

ERIC Educational Resources Information Center

Jackson, Angela Coleman

2014-01-01

The purpose of this study was to examine the effect of suspension as a deterrent to student misconduct. A mixed methods approach using both qualitative (interviews of administrators and teachers) and quantitative (discipline records of identified sixth graders) were utilized. In this case study approach, one-on-one semi-structured interviews were…

Field evaluation of jail sanctions for DWI

DOT National Transportation Integrated Search

1988-04-29

The objective of this study was to evaluate the effect of Tennessee's two-day mandatory jail sanction for first-offense DWI on general deterrence, special deterrence, and the operation of the drinking-driver control system. Our analysis of general de...

Effects of an electric field on white sharks: in situ testing of an electric deterrent.

PubMed

Huveneers, Charlie; Rogers, Paul J; Semmens, Jayson M; Beckmann, Crystal; Kock, Alison A; Page, Brad; Goldsworthy, Simon D

2013-01-01

Elasmobranchs can detect minute electromagnetic fields, <1 nV cm(-1), using their ampullae of Lorenzini. Behavioural responses to electric fields have been investigated in various species, sometimes with the aim to develop shark deterrents to improve human safety. The present study tested the effects of the Shark Shield Freedom7™ electric deterrent on (1) the behaviour of 18 white sharks (Carcharodon carcharias) near a static bait, and (2) the rates of attacks on a towed seal decoy. In the first experiment, 116 trials using a static bait were performed at the Neptune Islands, South Australia. The proportion of baits taken during static bait trials was not affected by the electric field. The electric field, however, increased the time it took them to consume the bait, the number of interactions per approach, and decreased the proportion of interactions within two metres of the field source. The effect of the electric field was not uniform across all sharks. In the second experiment, 189 tows using a seal decoy were conducted near Seal Island, South Africa. No breaches and only two surface interactions were observed during the tows when the electric field was activated, compared with 16 breaches and 27 surface interactions without the electric field. The present study suggests that the behavioural response of white sharks and the level of risk reduction resulting from the electric field is contextually specific, and depends on the motivational state of sharks.

Effects of an Electric Field on White Sharks: In Situ Testing of an Electric Deterrent

PubMed Central

Huveneers, Charlie; Rogers, Paul J.; Semmens, Jayson M.; Beckmann, Crystal; Kock, Alison A.; Page, Brad; Goldsworthy, Simon D.

2013-01-01

Elasmobranchs can detect minute electromagnetic fields, <1 nVcm–1, using their ampullae of Lorenzini. Behavioural responses to electric fields have been investigated in various species, sometimes with the aim to develop shark deterrents to improve human safety. The present study tested the effects of the Shark Shield Freedom7™ electric deterrent on (1) the behaviour of 18 white sharks (Carcharodon carcharias) near a static bait, and (2) the rates of attacks on a towed seal decoy. In the first experiment, 116 trials using a static bait were performed at the Neptune Islands, South Australia. The proportion of baits taken during static bait trials was not affected by the electric field. The electric field, however, increased the time it took them to consume the bait, the number of interactions per approach, and decreased the proportion of interactions within two metres of the field source. The effect of the electric field was not uniform across all sharks. In the second experiment, 189 tows using a seal decoy were conducted near Seal Island, South Africa. No breaches and only two surface interactions were observed during the tows when the electric field was activated, compared with 16 breaches and 27 surface interactions without the electric field. The present study suggests that the behavioural response of white sharks and the level of risk reduction resulting from the electric field is contextually specific, and depends on the motivational state of sharks. PMID:23658766

Trends & Controversies: Sociocultural Predictive Analytics and Terrorism Deterrence

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sanfilippo, Antonio P.; McGrath, Liam R.

2011-08-12

The use of predictive analytics to model terrorist rhetoric is highly instrumental in developing a strategy to deter terrorism. Traditional (e.g. Cold-War) deterrence methods are ineffective with terrorist groups such as al Qaida. Terrorists typically regard the prospect of death or loss of property as acceptable consequences of their struggle. Deterrence by threat of punishment is therefore fruitless. On the other hand, isolating terrorists from the community that may sympathize with their cause can have a decisive deterring outcome. Without the moral backing of a supportive audience, terrorism cannot be successfully framed as a justifiable political strategy and recruiting ismore » curtailed. Ultimately, terrorism deterrence is more effectively enforced by exerting influence to neutralize the communicative reach of terrorists.« less

Deterrent Concentration Measurement with FTIR and Subsequent Ballistic Performance in Medium Caliber Propellant

NASA Technical Reports Server (NTRS)

Furrow, Keith W.; Ritchie, Steve J.; Morris, Amy

2000-01-01

To meet ballistic requirements, medium and small caliber propellants use deterrent coatings to obtain burn rate progressivity. The required amount and distribution of deterrent varies between gun systems, propellant types, and often between lots. Micro Fourier Transform Infrared (FTIR) spectroscopy was used to measure deterrent gradients in RP36 propellants coated with methyl centralite (MC) at different deterrent levels and different processing conditions. The aromatic C-C bonds at 1496 cm(exp -1) wavenumber were used to monitor the deterrent profiles through the grain. Deterrent gradients measured with FTIR spectroscopy were then used to estimate burn rate gradients in the deterred grains. Burn rates were calculated from literature models and from closed bomb data of RP36 containing uniform deterrent concentration. Finally, the burn rate gradients were input into an IBHFG2 model of a 200 cc-closed bomb. The early flame spreading portion of the closed bomb ballistic cycle (0 to 0.2 P/Pmax) was roughly modeled by dividing the charge up into five propellant decks and igniting them at different times in the ballistic cycle. Pressure traces and vivacity curves from closed bomb shots were compared to predictions. In addition to the burn rate gradient, the closed bomb pressure trace was heavily dependent on ignition and flame spread. These two phenomena were not readily distinguishable from one another in deterred grains. The same RP-36 propellant was shot in a 25 mm M793TP round which was again modeled with IBHVG2. Peak pressure and muzzle velocity were accurately modeled when erosive burning effects were empirically factored into the model.

Cult of deterrence: A moral and strategic critique of the anti-ballistic missile treaty. Master`s thesis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pringle, C.S.

1997-12-30

Ballistic missile defense is the morally and strategically superior alternative to the current system of deterrence, provided that it is responsibly implemented. Analysis of the Just War Criteria and the utilitarian justifications of deterrence present a moral obligation to pursue the alternative strategy of missile defense as a means of defending the United States. However, the Anti-Ballistic Missile (ABM) Treaty does not allow earnest pursuit of this alternative, despite recent efforts to exploit its loopholes and broaden its meaning beyond any reasonable limit. Moreover, deterrence can no longer provide the guarantee of security that it did during the Cold War.more » Offense-Defense Theory shows that revisionist states are not subject to the same calculations of effective deterrence that the Soviet Union was during that period. This strategic analysis underlies the moral evaluations and further supports missile defense. The cult of deterrence is presented as an explanation for the failure to adapt national security policy to the new international structure, as European powers failed to perceive the offense-defense balance prior to World War I. The ABM regime threatens to reproduce those same mistakes with even greater consequences.« less

The effects of initial participation motivations on learning engagement in transition training for future general practitioners in rural China: perceived deterrents as mediator

PubMed Central

Cui, Guan-yu; Yao, Mei-lin; Zhang, Xia; Guo, Yan-kui; Li, Hui-min; Yao, Xiu-ping

2016-01-01

Background For the shortage of high-quality general practitioners (GPs) in China's rural areas, Chinese government has taken steps to encourage rural specialists to participate in transition training for future GPs. Specialists’ initial participation motivations and their perceived deterrents during training may play important roles for their learning engagement in the transition training. This study aimed at revealing the relationships among the variables of initial participation motivations, perceived deterrents in training, and learning engagement. Methods A questionnaire survey was used in this study. A total of 156 rural specialists who participated in transition training for future GPs filled out the questionnaire, which consisted of the measurements of initial participation motivations, perceived deterrents, and learning engagement in training. The data about specialists’ demographic variables were collected at the same time. Results The variance of initial escape/stimulations motivation significantly predicted the variance of learning engagement through the full mediating role of perceived deterrents in training. In addition, initial educational preparation motivations predicted the variance of learning engagement directly. Conclusions Specialists’ initial participation motivations and perceived deterrents in training played important roles for learning engagement in the transition training. PMID:27340086

JPRS Report, China

DTIC Science & Technology

1989-11-17

study of soil physical properties. At present, we have established field experimental plots in the loessial plain of the lower Yellow River, provided... effect on the military strength of countries all over the world. Under present conditions, science, technology, and economics are making unprec... effect deterrence, but are also producing profound changes in the methods of deterrence. Looking at the strategic situation worldwide, scientific

Motivators and deterrents to blood donation among Black South Africans: a qualitative analysis of focus group data.

PubMed

Muthivhi, T N; Olmsted, M G; Park, H; Sha, M; Raju, V; Mokoena, T; Bloch, E M; Murphy, E L; Reddy, R

2015-08-01

South Africa has a markedly skewed representation where the majority of blood (62%) is presently collected from an ethnically White minority. This study seeks to identify culturally specific factors affecting motivation of donors in South Africa. We performed a qualitative study to evaluate motivators and deterrents to blood donation among Black South Africans. A total of 13 focus groups, comprising a total of 97 Black South Africans, stratified by age and geographic location were conducted. Transcripts of the interviews were analysed using a coding framework by Bednall & Bove. Participants made 463 unique comments about motivators focusing primarily on promotional communications (28%), incentives (20%) and prosocial motivation (16%). Participants made 376 comments about deterrents which focused primarily on fear (41%), negative attitudes (14%) and lack of knowledge (10%). Although prosocial motivation (altruism) was the most frequently mentioned individual motivator, promotional communication elicited more overall comments by participants. As reported by many authors, fear and lack of awareness were strong deterrents, but scepticism engendered by perceived racial discrimination in blood collection were unique to the South African environment. © 2015 British Blood Transfusion Society.

Nectar Attracts Foraging Honey Bees with Components of Their Queen Pheromones.

PubMed

Liu, Fanglin; Gao, Jie; Di, Nayan; Adler, Lynn S

2015-11-01

Floral nectar often contains chemicals that are deterrent to pollinators, presenting potential challenges to outcrossing plant species. Plants may be able to co-opt pollinator chemical signals to mitigate the negative effects of nectar deterrent compounds on pollination services. We found that buckwheat (Fagopyrum esculentum) and Mexican sunflower (Tithonia diversifolia) produce nectar with abundant phenolics, including three components of the Apis honeybee queen mandibular pheromone (QMP). In addition, these nectars contain a non-pheromonal phenolic, chlorogenic acid (CA), which was toxic to honeybees, and T. diversifolia nectar also contained isochlorogenic acid (IA). Fresh nectar or solutions containing nectar phenolics reduced Apis individual feeding compared to sucrose solutions. However, freely foraging bees preferred solutions with QMP components to control solutions, and QMP components over-rode or reversed avoidance of CA and IA. Furthermore, prior exposure to the presence or just the odor of QMP components removed the deterrent effects of CA and IA. By mimicking the honey bee pheromone blend, nectar may maintain pollinator attraction in spite of deterrent nectar compounds.

Oviposition deterrent and skin repellent activities of Solanum trilobatum leaf extract against the malarial vector Anopheles stephensi.

PubMed Central

Rajkumar, S.; Jebanesan, A.

2005-01-01

The leaf extract of Solanum trilobatum (Solanaceae) was tested under laboratory conditions for oviposition deterrent and skin repellent activities against the adult mosquito Anopheles stephensi. Concentrations of 0.01, 0.025, 0.05, 0.075 and 0.1% reduced egg laying by gravid females from 18 to 99% compared to ethanol-treated controls. In skin repellent tests, concentrations of 0.001, 0.005, 0.01, 0.015, and 0.02 % provided 70 to 120 minutes protection against mosquito bites, whereas the ethanol control provided only 2.2 minutes of protection. Both oviposition deterrent and skin repellent activity were dose dependent. The results suggest that the leaf extract of S. trilobatum is an effective oviposition deterrent and skin repellent against An. stephensi. PMID:16341247

Strategic Flexibility to Deter in the Asia Pacific

DTIC Science & Technology

2016-01-01

result will occur. This posture, while often effective , ac- tually limits response options for policy makers, essentially requiring the establishment...to the de- terrent effect of a range of policy options supported by the breadth of the nation’s instruments of power and “unguided by an overt...deterrence policy”; some define this deterrent effect as dissuasion, as does this article, although in the Department of Defense’s (DOD) joint doctrine

Strategies to reduce driving under the influence of alcohol.

PubMed

DeJong, W; Hingson, R

1998-01-01

The purpose of this review is to update research on the prevention of alcohol-related traffic deaths since the 1988 Surgeon General's Workshop on Drunk Driving. Four primary areas of research are reviewed here: (a) general deterrence policies, (b) alcohol control policies, (c) mass communications campaigns, including advertising restrictions, and (d) community traffic safety programs. Modern efforts to combat drunk driving in the United States began with specific deterrence strategies to punish convicted drunk drivers, and then evolved to include general deterrence strategies that were targeted to the population as a whole. Efforts next expanded to include the alcohol side of the problem, with measures installed to decrease underage drinking and excessive alcohol consumption. In the next several years, greater efforts are needed on all these fronts. Also needed, however, are programs that integrate drunk driving prevention with other traffic safety initiatives.

Enforcement, adjudication and public information strategies for the general deterrence of driving while intoxicated : information for potential field site participants

DOT National Transportation Integrated Search

1982-10-01

The National Highway Traffic Safety Administration (NHTSA) through a contract with the University of North Carolina Highway Safety Research Center (HSRC) is intending to field test the effectiveness of selected general deterrence programs directed at...

Effects of acoustic deterrents on foraging bats

Treesearch

Joshua B. Johnson; W. Mark Ford; Jane L. Rodrigue; John W. Edwards

2012-01-01

Significant bat mortality events associated with wind energy expansion, particularly in the Appalachians, have highlighted the need for development of possible mitigation practices to reduce or prevent strike mortality. Other than increasing turbine cut-in speed, acoustic deterrents probably hold the greatest promise for reducing bat mortality. However, acoustic...

Bomber Deterrence Missions: Criteria To Evaluate Mission Effectiveness

DTIC Science & Technology

2016-02-16

International Relations from Brigham Young University and a Master of Science degree in Aviation Safety Management from the University of Central...AIR WAR COLLEGE AIR UNIVERSITY BOMBER DETERRENCE MISSIONS: CRITERIA TO EVALUATE MISSION EFFECTIVENESS by Bradley L. Cochran, Col, USAF A...paper are those of the author and do not reflect the official policy or position of the US government, the Department of Defense, or Air University

"Deterrability" among Gang and Nongang Juvenile Offenders: Are Gang Members More (or Less) Deterrable than Other Juvenile Offenders?

ERIC Educational Resources Information Center

Maxson, Cheryl L.; Matsuda, Kristy N.; Hennigan, Karen

2011-01-01

This study investigates the effect of the threat of legal sanctions on intentions to commit three types of offenses with a representative sample of 744 officially adjudicated youth with varying histories of offenses and gang involvement. In a departure from previous research, the authors find small severity effects for property crimes that are not…

Taste detection of the non-volatile isothiocyanate moringin results in deterrence to glucosinolate-adapted insect larvae.

PubMed

Müller, Caroline; van Loon, Joop; Ruschioni, Sara; De Nicola, Gina Rosalinda; Olsen, Carl Erik; Iori, Renato; Agerbirk, Niels

2015-10-01

Isothiocyanates (ITCs), released from Brassicales plants after hydrolysis of glucosinolates, are known for their negative effects on herbivores but mechanisms have been elusive. The ITCs are initially present in dissolved form at the site of herbivore feeding, but volatile ITCs may subsequently enter the gas phase and all ITCs may react with matrix components. Deterrence to herbivores resulting from topically applied volatile ITCs in artificial feeding assays may hence lead to ambiguous conclusions. In the present study, the non-volatile ITC moringin (4-(α-L-rhamnopyranosyloxy)benzyl ITC) and its glucosinolate precursor glucomoringin were examined for effects on behaviour and taste physiology of specialist insect herbivores of Brassicales. In feeding bioassays, glucomoringin was not deterrent to larvae of Pieris napi (Lepidoptera: Pieridae) and Athalia rosae (Hymenoptera: Tenthredinidae), which are adapted to glucosinolates. Glucomoringin stimulated feeding of larvae of the related Pieris brassicae (Lepidoptera: Pieridae) and also elicited electrophysiological activity from a glucosinolate-sensitive gustatory neuron in the lateral maxillary taste sensilla. In contrast, the ITC moringin was deterrent to P. napi and P. brassicae at high levels and to A. rosae at both high and low levels when topically applied to cabbage leaf discs (either 12, 120 or 1200 nmol moringin per leaf disc of 1cm diameter). Survival of A. rosae was also significantly reduced when larvae were kept on leaves treated with moringin for several days. Furthermore, moringin elicited electrophysiological activity in a deterrent-sensitive neuron in the medial maxillary taste sensillum of P. brassicae, providing a sensory mechanism for the deterrence and the first known ITC taste response of an insect. In simulated feeding assays, recovery of moringin was high, in accordance with its non-volatile nature. Our results demonstrate taste-mediated deterrence of a non-volatile, natural ITC to glucosinolate-adapted insects. Copyright © 2015 Elsevier Ltd. All rights reserved.

Motivators and deterrents to blood donation among Black South Africans: a qualitative analysis of focus group data

PubMed Central

Muthivhi, T. N.; Olmsted, M. G.; Park, H.; Sha, M.; Raju, V.; Mokoena, T.; Bloch, E. M.; Murphy, E. L.; Reddy, R.

2015-01-01

SUMMARY Background and Objectives South Africa has a markedly skewed representation where the majority of blood (62%) is presently collected from an ethnically White minority. This study seeks to identify culturally specific factors affecting motivation of donors in South Africa. Materials and Methods We performed a qualitative study to evaluate motivators and deterrents to blood donation among Black South Africans. A total of 13 focus groups, comprising a total of 97 Black South Africans, stratified by age and geographic location were conducted. Transcripts of the interviews were analysed using a coding framework by Bednall & Bove. Results Participants made 463 unique comments about motivators focusing primarily on promotional communications (28%), incentives (20%) and prosocial motivation (16%). Participants made 376 comments about deterrents which focused primarily on fear (41%), negative attitudes (14%) and lack of knowledge (10%). Conclusion Although prosocial motivation (altruism) was the most frequently mentioned individual motivator, promotional communication elicited more overall comments by participants. As reported by many authors, fear and lack of awareness were strong deterrents, but scepticism engendered by perceived racial discrimination in blood collection were unique to the South African environment. PMID:26104809

West European and East Asian Perspectives on Defense, Deterrence and Strategy. Volume 6. South Korean Perspectives on Defense, Deterrence and Strategy.

DTIC Science & Technology

1984-04-11

8217IN.2 AD-A166 115 DNA-TR-84-109-V6 ’’ WEST EUROPEAN AND EAST ASIAN PERSPECTIVES ON DEFENSE, DETERRENCE AND STRATEGY Volume VI-South Korean Perspectives...on Defense, Deterrence and J. Strategy Institute for Foreign Policy Analysis Central Plaza Building 675 Massachusetts Avenue Cambridge, MA 02139...PERSPECTIVES ON DEFENSE, DETERRENCE AND STRATEGY Volume VI-South Korean Perspectives on Defense, Deterrence and Strategy 12 PERSONALAUTHOR(S

Why leaders punish: A power perspective.

PubMed

Mooijman, Marlon; van Dijk, Wilco W; Ellemers, Naomi; van Dijk, Eric

2015-07-01

We propose that power fundamentally changes why leaders punish and we develop a theoretical model that specifies how and why this occurs. Specifically, we argue that power increases the reliance on deterrence, but not just deserts, as a punishment motive and relate this to power fostering a distrustful mindset. We tested our model in 9 studies using different instantiations of power, different measurements and manipulations of distrust while measuring punishment motives and recommended punishments across a number of different situations. These 9 studies demonstrate that power fosters distrust and hereby increases both the reliance on deterrence as a punishment motive and the implementation of punishments aimed at deterrence (i.e., public punishments, public naming of rule breakers and punishments with a mandatory minimum). We discuss the practical implications for leaders, managers and policymakers and the theoretical implications for scholars interested in power, trust, and punishments. (c) 2015 APA, all rights reserved).

Strategic Personality and the Effectiveness of Nuclear Deterrence: Deterring Iraq and Iran

DTIC Science & Technology

2001-09-01

ES-1 I. NUCLEAR DETERRENCE AND THREAT REDUCTION IN THE ERA OF THE “KOSOVO SYNDROME ...without the Kosovo Syndrome ? ................................... 106 Appendix A: The Strategic Personality Types...the United States from intervening in their future internal ethnic, religious, political, or regional disputes. The rise of this “Kosovo Syndrome

Here to Help: Third Party Deterrence Against Insurgent Groups

DTIC Science & Technology

2015-05-22

that the new threat “of delinquent states and shadowy terrorist groups” was beyond the effects of deterrence.8 However, for those seeking an alternative...foreignpolicy.com/2014/05/08/portrait-of-the-army-as-a-work-in-progress. 28 Statistically , there is reason to favor joint training programs, with the aim

Feeding deterrence and inhibitory effects of bee balm (Monarda didyma) leaves on fall armyworm

USDA-ARS?s Scientific Manuscript database

The fall armyworm [Spodoptera frugiperda (J.E. Smith)] is a serious pest of many field and horticulture crops. Because of the many advantages for the use of plant-derived pesticides, we tested whether bee balm (Monarda didyma L.) leaves could have feeding deterrence on fall armyworm. When S. frugipe...

Aedes aegypti (Diptera: culicidae) biting deterrence: structure-activity relationship of saturated and unsaturated fatty acids

USDA-ARS?s Scientific Manuscript database

In this study we systematically evaluated for the first time the biting deterrent effects of a series of saturated and unsaturated fatty acids against Aedes aegypti [yellow fever mosquito (Diptera: Culicidae)] using the K & D bioassay system (Klun et al 2005). The saturated fatty acids (C6:0 to C16...

The Prospects of Employing Semiochemical and Visual Deterrents in Protecting Trees from Bark Beetles

Treesearch

B.L. Strom; L.M. Roton; J.L. Hayes; R.A. Goyer

1996-01-01

Tree protection tactics based on semiochemicals are being investigated by many forest scientists but their consistent effectiveness remains a concern. One approach toward increasing the efficacy of such treatments is to combine semiochemically-based tactics with deterrents that disrupt other cues necessary for host finding and colonization. In this study we...

Current Impact and Application of Abuse-Deterrent Opioid Formulations in Clinical Practice.

PubMed

Lee, Ya-Han; Brown, Daniel L; Chen, Hsiang-Yin

2017-11-01

Abuse-deterrent formulations (ADFs) represent one novel strategy for curbing the potential of opioid abuse. We aim to compare and contrast the characteristics and applications of current abuse-deterrent opioid products in clinical practice. Literature searches were conducted in databases (Pubmed Medline, International Pharmaceutical Abstracts, Google Scholar) and official reports. Relevant data were screened and organized into: 1) epidemiology of opioid abuse, 2) mitigation strategies for reducing opioid abuse, 3) development of ADFs, and 4) clinical experience with these formulations. Increasing trends of opioid abuse and misuse have been reported globally. There are 5 types of abuse-deterrent opioid products: physical chemical barrier, combined agonist/antagonist, sequestered aversive agent, prodrug, and novel delivery system. The advantages and disadvantages of the 5 options are discussed in this review. A total of 9 products with abuse-deterrent labels have been approved by the Food and Drug Administration (FDA). The rates of abuse, diversion, and overdose deaths of these new products are also discussed. A framework for collecting in-time data on the efficacy, benefit and risk ratio, and cost-effectiveness of these new products is suggested to facilitate their optimal use. The present review did not utilize systematic review standards or meta-analytic techniques, given the large heterogeneity of data and outcomes reviewed. ADFs provide an option for inhibiting the abuse or misuse of oral opioid products by hindering extraction of the active ingredient, preventing alternative routes of administration, or causing aversion. Their relatively high costs, uncertain insurance policies, and limited data on pharmacoeconomics warrant collaborative monitoring and assessment by government agencies, pharmaceutical manufacturers, and data analysis services to define their therapeutic role in the future. Opioid abuse, abuse-deterrent formulations, ADF, post-marketing, FDA guidance, cost impact, abuse liking, physician attitude, generic abuse-deterrent formulation, clinical application.

Predicting DUI decisions in different legal environments: investigating deterrence with a conjoint experiment.

PubMed

Yao, Jie; Johnson, Mark B; Beck, Kenneth H

2014-01-01

Driving under the influence (DUI) enforcement practices and sanctions contribute differentially to the certainty, swiftness, and severity of punishment, which are the key components of general deterrence theory. This study used a conjoint experiment to understand the decision-making process of potential DUI offenders and tested how variation in enforcement and legal punishment affects drinking and driving decisions. It sought to verify and quantify the unique deterrent effects of certainty, severity, and swiftness and to predict the rates of drinking and driving in different legal environments. One hundred twenty-one college seniors and graduate students at the University of Maryland participated in the Web-based conjoint experiment. They were randomly assigned to 4 blocks, each of which included 9 hypothetical scenarios composed of different levels of DUI enforcement and penalties. Respondents were asked to state their likelihood of drinking and driving under each scenario, as well as their estimated chance of being caught by the police for DUI. Intensified enforcement, harsh jail penalty, and immediate long license suspension were found to be the strongest deterrents to drinking and driving. Alternative ways to get home were also important in reducing people's willingness to drive. These factors accounted for most of the attribute effect on the DUI decision, whereas delayed punishment due to judicial processing, fine penalty, and legal blood alcohol concentration (BAC) limit had negligible effects. For the personal characteristics, college seniors and those who had previously driven after drinking were more likely to choose to drink and drive, whereas those who expect a jail penalty for a DUI offense were less likely to drive. Our research confirmed and quantified certainty of punishment as the greatest deterrent to DUI, but it also indicated the equally important effect of a severe jail penalty. It provides evidence on the feasibility of using a conjoint experiment in future studies to understand the general driver population and, with the help of a simulation tool, to predict DUI decisions in different legal environments. Such predictions can be used to better inform policy decisions on developing targeted general deterrence programs in different communities.

Oviposition-altering and ovicidal potentials of five essential oils against female adults of the dengue vector, Aedes aegypti L.

PubMed

Warikoo, Radhika; Wahab, Naim; Kumar, Sarita

2011-10-01

The oviposition deterrence and ovicidal potential of five different essential oils, peppermint oil (Mentha piperita), basil oil (Ocimum basilicum), rosemary oil (Rosemarinus officinalis), citronella oil (Cymbopogon nardus), and celery seed oil (Apium graveolens), were assessed against female adults of the dengue vector, Aedes aegypti L. Multiple concentration tests were carried out where cups containing 1 mL of different concentrations (100%, 10%, 1%, 0.1%) of the oils and 199 mL of water were used for oviposition. The number of eggs laid and the larvae hatched in each cup were scored to evaluate the oviposition deterrent and ovicidal potentials of the oils. Our investigations revealed that the addition of 100% oil (pure oil) caused complete oviposition deterrence except in A. graveolens which resulted in 75% effective repellency. The use of 10% oil resulted in the maximum deterrence of 97.5% as shown by the M. piperita oil while other oils caused 36-97% oviposition deterrence as against the control. The oviposition medium with 1% oil showed decreased deterrent potential with 30-64% effective repellency, the M. piperita oil being exceptional. However, as the concentrations of the oil were reduced further to 0.1%, the least effective oil observed was A. graveolens (25% ER). Also, the M. piperita oil showed much reduced activity (40%) as compared to the control, while the other oils exhibited 51-58% repellency to oviposition. The studies on the ovicidal effects of these oils revealed that the eggs laid in the water with 100% essential oils did not hatch at all, whereas when 10% oils were used, only the R. officinalis oil resulted in 28% egg hatch. At lower concentrations (1%), the oils of M. piperita, O. basilicum, and C. nardus showed complete egg mortality while those of A. graveolens and R. officinalis resulted in 71% and 34% egg hatches, respectively. When used at 0.1%, the O. basilicum oil was found to be the only effective oil with 100% egg mortality, whereas other oils resulted in 16-76% egg mortality, the least mortality caused by the A. graveolens oil. These results suggest that these essential oils can be employed in a resistance-management program against A. aegypti. Further detailed research is needed to identify the active ingredient in the extracts and implement the effective mosquito management program.

"Selling smarter, not harder": Life course effects on drug sellers' risk perceptions and management.

PubMed

Fader, Jamie J

2016-10-01

Policies undergirding the American War on Drugs assume that drug offenders respond rationally to adjustments in sanction certainty and severity. Previous studies find that instead of absolute deterrence, or the termination of criminal activity, drug offenders employ restrictive deterrence, or a variety of risk management strategies. Extant research and current drug policy both fail to examine the interaction of risk perception, management techniques, and life course events or circumstances. This dynamic examination of apprehension avoidance strategies relies on in-depth interviews mapping out the careers of 20 drug sellers in Philadelphia, Pennsylvania. It examines their risk perceptions and risk management strategies and techniques, exploring rationales for shifts in offending behavior. Respondents were highly risk-averse but used a narrow definition of sanctions relevant to shaping future offending behavior, typically making small adjustments in sales techniques. Rationales for these shifts included sanctions, personal preference, and life course events or circumstances. Only one attributed lasting desistance from offending to a sanction, although life course events such as parenthood and employment were associated with short-term and planned desistance. The limited relevance of sanctions to offenders' thinking about risk avoidance contextualizes the widespread failure of policies designed to deter drug sales. Findings support a growing conclusion that severity of punishment is a less powerful deterrent than certainty and that adjustments in certainty after arrest are offense-specific. The relationship of life course events - especially employment - to desistance and resumed offending suggest that social policies may be more effective than criminal justice sanctions in reducing drug offending. Copyright © 2016 Elsevier B.V. All rights reserved.

The Future of US Nuclear Deterrence and the Impact of the Global Zero Movement

DTIC Science & Technology

2013-02-10

The most appealing GZC recommendation is for a de facto minimum deterrence model en route to GZ. To its detriment, however, the GZC proposal relies...difficult to dispute that this path leads, at least eventually, to a minimum deterrence model . It is likely that the US can continue to wield a...instead, a capable, credible deterrent is critical to countering these threats and is especially so in a minimum deterrence model . Two key

How to Reduce Those Costly School Bus Accidents.

ERIC Educational Resources Information Center

Farmer, Ernest

1985-01-01

The deterrent to school bus accidents is preparedness. Training programs for drivers and mechanics, equipment specifications, and a community support base are some of the ways to prevent tragedy. (MLF)

The effect of an abuse‐deterrent opioid formulation (OxyContin) on opioid abuse‐related outcomes in the postmarketing setting

PubMed Central

Chilcoat, HD; Butler, SF; Sellers, EM; Kadakia, A; Harikrishnan, V; Haddox, JD; Dart, RC

2016-01-01

An extended‐release opioid analgesic (OxyContin, OC) was reformulated with abuse‐deterrent properties to deter abuse. This report examines changes in abuse through oral and nonoral routes, doctor‐shopping, and fatalities in 10 studies 3.5 years after reformulation. Changes in OC abuse from 1 year before to 3 years after OC reformulation were calculated, adjusted for prescription changes. Abuse of OC decreased 48% in national poison center surveillance systems, decreased 32% in a national drug treatment system, and decreased 27% among individuals prescribed OC in claims databases. Doctor‐shopping for OC decreased 50%. Overdose fatalities reported to the manufacturer decreased 65%. Abuse of other opioids without abuse‐deterrent properties decreased 2 years later than OC and with less magnitude, suggesting OC decreases were not due to broader opioid interventions. Consistent with the formulation, decreases were larger for nonoral than oral abuse. Abuse‐deterrent opioids may mitigate abuse and overdose risks among chronic pain patients. PMID:27170195

''Whither Deterrence?'' A Brief Synopsis May, 2002

DOE Office of Scientific and Technical Information (OSTI.GOV)

Poppe, C; Vergino, E; Barker, R

To most audiences, deterrence has been interconnected with nuclear weapons whose purpose had been to deter a Soviet attack. But, the Soviet Union has been gone for almost a decade. President George W. Bush has stated that Russia is not an enemy of the US and the numbers of nuclear weapons can be dramatically reduced. It is important to note that deterrence has always transcended nuclear weapons. The US' first line of deterrence has been its formidable conventional warfare capability, designed to prevent conflict and win wars if necessary. The role of nuclear weapons has been to deter the,use ofmore » nuclear weapons and other weapons of mass destruction against U.S. interests during the conduct of conventional warfare and to ensure our ability to inflict massive destruction on any who would use nuclear weapons, or other weapons of mass destruction, against us. With regard to the Soviet Union, the threat of the use of nuclear weapons was a critical component of our deterrent to prevent massive Soviet conventional attack against our allies in Europe. However, the events of September 11, 2001 make clear that we have not convinced all who seek to harm us that we will be able to respond in a manner to make them wish they had not even tried. The September 11 attacks, as well as other past conflicts, do not mean that deterrence has failed-it remains effective against the threats for which it was designed. We have known there are other threats for which we did not have a credible deterrent. The challenge is to sustain deterrence against the classic threats as they evolve in technical sophistication while remaining alert to the need to evaluate continuously our ability to deter previously unforeseen challenges. How then should we be looking at deterrence as we consider fifteen or so years in the future, say to about 2015? What will be the role of nuclear weapons and other instruments of mass destruction in the future? What should the US be doing to prepare for the future? In this study, we present four futures as a tool for planners who must think ahead fifteen years or more, rather than a prediction of the future. None of the four futures will emerge in just the way we have described. Fifteen years from now, some mix of these futures is more likely, or perhaps we will see a trend towards one of the futures, but with the possibility that any of the other three could appear, perhaps quite swiftly. Any future will undoubtedly contain its own kind of unpleasant surprises and, in contrast to the Cold War; the possession of enormous nuclear-response and conventional-response capability may not be sufficient to deter these from happening. However, there are other tools that the US must include as part of its strategy and security policy in addition to deterrence, specifically dissuasion, defense, destruction, and assurance. Rather than rely on the Cold-War concept of deterrence, future security policy should be built upon the appropriate mix of these elements as a way to steer us toward a more favorable future, while ensuring that we are prepared for the kinds of surprises associated with far less favorable futures. In this study, we have defined three unfavorable futures to be avoided, and one future that represents, we believe, a more desirable global situation than the first three, but still not entirely benign. Our security policy should be defined to avoid or prevent the first three, which we have entitled ''Nuclear Giants, Global Terror'', and ''Regional Nuclear Tension and Use'', and steer us toward a more favorable future, ''Dynamic Cooperation''. We have examined the implications for both policy and military capability that are posed by these different futures. The result often raises more questions than we are able to answer without additional study-however, our primary purpose was to clarify the issues, to identify. what we believe we know, what we don't know, and where more study and effort are needed. Nevertheless, in preparing for unfavorable futures, we must also identify and plan the future we want. This study emphasizes that a desirable future in 2015 would be characterized by peaceful resolution of conflict, growing worldwide economic prosperity, an effective non-proliferation regime, the ability of the United States to control its own destiny without conflict, and expansion of political and economic freedom. Security policies, even in the face of unpleasant futures, should be crafted so as enhance, rather than diminish, these desired goals.« less

Legal liability perspectives on abuse-deterrent opioids in the treatment of chronic pain.

PubMed

Brushwood, David B; Rich, Ben A; Coleman, John J; Bolen, Jennifer; Wong, Winston

2010-12-01

Abuse-deterrent opioid analgesic formulations can help reduce the risk of opioid diversion and abuse. Not all opioid analgesics are available as both extended- and immediate-release dosage forms in abuse-deterrent formulations. Clinicians may have to balance the clinical benefit of a product that does not use abuse-deterrent technology versus the regulatory benefit of using a product with this technology. There is the possibility that a health care professional may be held legally liable when a product without abuse-deterrent qualities is used and a person suffers harm that would not have occurred had an abuse-deterrent formulation been provided. This article reviews legal precedents that inform an understanding of the need to reduce malpractice exposure by identifying patients who are at high risk of opioid diversion and/or abuse and considering the use of an abuse-deterrent formulation for these patients.

Protocol: changes in rates of opioid overdose and poisoning events in an integrated health system following the introduction of a formulation of OxyContin® with abuse-deterrent properties.

PubMed

Janoff, Shannon L; Perrin, Nancy A; Coplan, Paul M; Chilcoat, Howard D; Campbell, Cynthia I; Green, Carla A

2016-05-14

Addiction, overdoses and deaths resulting from prescription opioids have increased dramatically over the last decade. In response, several manufacturers have developed formulations of opioids with abuse-deterrent properties. For many of these products, the Food and Drug Administration (FDA) recognized the formulation with labeling claims and mandated post-marketing studies to assess the abuse-deterrent effects. In response, we assess differences in rates of opioid-related overdoses and poisonings prior to and following the introduction of a formulation of OxyContin® with abuse-deterrent properties. To assess effects of this formulation, electronic medical record (EMR) data from Kaiser Permanente Northwest (KPNW) and Kaiser Permanente Northern California (KPNC) are linked to state death data and compared to chart audits. Overdose and poisoning events will be categorized by intentionality and number of agents involved, including illicit drugs and alcohol. Using 6-month intervals over a 10-year period, trends will be compared in rates of opioid-related overdoses and poisoning events associated with OxyContin® to rates of events associated with other oxycodone and opioid formulations. Qualitative interviews with patients and relatives of deceased patients will be conducted to capture circumstances surrounding events. This study assesses and tracks changes in opioid-related overdoses and poisoning events prior to and following the introduction of OxyContin® with abuse-deterrent properties. Public health significance is high because these medications are designed to reduce abuse-related behaviors that lead to important adverse outcomes, including overdoses and deaths.

Document fraud deterrent strategies: four case studies

NASA Astrophysics Data System (ADS)

Mercer, John W.

1998-04-01

This paper discusses the approaches taken to deter fraud committed against four documents: the machine-readable passport; the machine-readable visa; the Consular Report of Birth Abroad; and the Border Crossing Card. General approaches are discussed first, with an emphasis on the reasons for the document, the conditions of its use and the information systems required for it to function. A cost model of counterfeit deterrence is introduced. Specific approaches to each of the four documents are then discussed, in light of the issuance circumstances and criteria, the intent of the issuing authority, the applicable international standards and the level of protection and fraud resistance appropriate for the document.

Gustatory receptor neuron responds to DEET and other insect repellents in the yellow-fever mosquito, Aedes aegypti

NASA Astrophysics Data System (ADS)

Sanford, Jillian L.; Shields, Vonnie D. C.; Dickens, Joseph C.

2013-03-01

Three gustatory receptor neurons were characterized for contact chemoreceptive sensilla on the labella of female yellow-fever mosquitoes, Aedes aegypti. The neuron with the smallest amplitude spike responded to the feeding deterrent, quinine, as well as N, N-diethyl-3-methylbenzamide and other insect repellents. Two other neurons with differing spikes responded to salt (NaCl) and sucrose. This is the first report of a gustatory receptor neuron specific for insect repellents in mosquitoes and may provide a tool for screening chemicals to discover novel or improved feeding deterrents and repellents for use in the management of arthropod disease vectors.

The effects of herbal essential oils on the oviposition-deterrent and ovicidal activities of Aedes aegypti (Linn.), Anopheles dirus (Peyton and Harrison) and Culex quinquefasciatus (Say).

PubMed

Siriporn, P; Mayura, S

2012-03-01

The effect of oviposition-deterrent and ovicidal of seven essential oils were evaluated towards three mosquito vectors, Aedes aegypti, Anopheles dirus and Culex quinquefasciatus. The oviposition activity index (OAI) values of six essential oils namely Cananga odorata, Cymbopogon citratus, Cymbopogon nardus, Eucalyptus citriodora, Ocimum basilicum and Syzygium aromaticum indicated that there were more deterrent than the control whereas Citrus sinensis oil acted as oviposition attractant. At higher concentration (10%) of Ca. odorata (ylang ylang flowers) showed high percent effective repellency (ER) against oviposition at 99.4% to Ae. aegypti, 97.1% to An. dirus and 100% to Cx. quinquefasciatus, respectively. The results showed that mean numbers of eggs were lower in treated than in untreated water. In addition, there was an inverse relationship between essential oil concentrations and ovicidal activity. As the concentration of essential oil increased from 1%, 5% and up to 10% conc., the hatching rate decreased. The essential oil of Ca. odorata at 10% conc. gave minimum egg hatch of 10.4% (for Ae. aegypti), 0.8% (for An. dirus) and 1.1% (for Cx. quinquefasciatus) respectively. These results clearly revealed that the essential oil of Ca. odorata served as a potential oviposition-deterrent and ovicidal activity against Ae. aegypti, An. dirus and Cx. quinquefasciatus.

Evaluating the Effectiveness of an Ultrasonic Acoustic Deterrent for Reducing Bat Fatalities at Wind Turbines.

PubMed

Arnett, Edward B; Hein, Cris D; Schirmacher, Michael R; Huso, Manuela M P; Szewczak, Joseph M

2013-01-01

Large numbers of bats are killed by wind turbines worldwide and minimizing fatalities is critically important to bat conservation and acceptance of wind energy development. We implemented a 2-year study testing the effectiveness of an ultrasonic acoustic deterrent for reducing bat fatalities at a wind energy facility in Pennsylvania. We randomly selected control and treatment turbines that were searched daily in summer and fall 2009 and 2010. Estimates of fatality, corrected for field biases, were compared between treatment and control turbines. In 2009, we estimated 21-51% fewer bats were killed per treatment turbine than per control turbine. In 2010, we determined an approximate 9% inherent difference between treatment and control turbines and when factored into our analysis, variation increased and between 2% more and 64% fewer bats were killed per treatment turbine relative to control turbines. We estimated twice as many hoary bats were killed per control turbine than treatment turbine, and nearly twice as many silver-haired bats in 2009. In 2010, although we estimated nearly twice as many hoary bats and nearly 4 times as many silver-haired bats killed per control turbine than at treatment turbines during the treatment period, these only represented an approximate 20% increase in fatality relative to the pre-treatment period for these species when accounting for inherent differences between turbine sets. Our findings suggest broadband ultrasound broadcasts may reduce bat fatalities by discouraging bats from approaching sound sources. However, effectiveness of ultrasonic deterrents is limited by distance and area ultrasound can be broadcast, in part due to rapid attenuation in humid conditions. We caution that an operational deterrent device is not yet available and further modifications and experimentation are needed. Future efforts must also evaluate cost-effectiveness of deterrents in relation to curtailment strategies to allow a cost-benefit analysis for mitigating bat fatalities.

Evaluating the Effectiveness of an Ultrasonic Acoustic Deterrent for Reducing Bat Fatalities at Wind Turbines

PubMed Central

Arnett, Edward B.; Hein, Cris D.; Schirmacher, Michael R.; Huso, Manuela M. P.; Szewczak, Joseph M.

2013-01-01

Large numbers of bats are killed by wind turbines worldwide and minimizing fatalities is critically important to bat conservation and acceptance of wind energy development. We implemented a 2-year study testing the effectiveness of an ultrasonic acoustic deterrent for reducing bat fatalities at a wind energy facility in Pennsylvania. We randomly selected control and treatment turbines that were searched daily in summer and fall 2009 and 2010. Estimates of fatality, corrected for field biases, were compared between treatment and control turbines. In 2009, we estimated 21–51% fewer bats were killed per treatment turbine than per control turbine. In 2010, we determined an approximate 9% inherent difference between treatment and control turbines and when factored into our analysis, variation increased and between 2% more and 64% fewer bats were killed per treatment turbine relative to control turbines. We estimated twice as many hoary bats were killed per control turbine than treatment turbine, and nearly twice as many silver-haired bats in 2009. In 2010, although we estimated nearly twice as many hoary bats and nearly 4 times as many silver-haired bats killed per control turbine than at treatment turbines during the treatment period, these only represented an approximate 20% increase in fatality relative to the pre-treatment period for these species when accounting for inherent differences between turbine sets. Our findings suggest broadband ultrasound broadcasts may reduce bat fatalities by discouraging bats from approaching sound sources. However, effectiveness of ultrasonic deterrents is limited by distance and area ultrasound can be broadcast, in part due to rapid attenuation in humid conditions. We caution that an operational deterrent device is not yet available and further modifications and experimentation are needed. Future efforts must also evaluate cost-effectiveness of deterrents in relation to curtailment strategies to allow a cost-benefit analysis for mitigating bat fatalities. PMID:23840369

Evaluating the effectiveness of an ultrasonic acoustic deterrent for reducing bat fatalities at wind turbines

USGS Publications Warehouse

Arnett, Edward B.; Hein, Cris D.; Schirmacher, Michael R.; Huso, Manuela M.P.; Szewczak, Joseph M.

2013-01-01

Large numbers of bats are killed by wind turbines worldwide and minimizing fatalities is critically important to bat conservation and acceptance of wind energy development. We implemented a 2-year study testing the effectiveness of an ultrasonic acoustic deterrent for reducing bat fatalities at a wind energy facility in Pennsylvania. We randomly selected control and treatment turbines that were searched daily in summer and fall 2009 and 2010. Estimates of fatality, corrected for field biases, were compared between treatment and control turbines. In 2009, we estimated 21–51% fewer bats were killed per treatment turbine than per control turbine. In 2010, we determined an approximate 9% inherent difference between treatment and control turbines and when factored into our analysis, variation increased and between 2% more and 64% fewer bats were killed per treatment turbine relative to control turbines. We estimated twice as many hoary bats were killed per control turbine than treatment turbine, and nearly twice as many silver-haired bats in 2009. In 2010, although we estimated nearly twice as many hoary bats and nearly 4 times as many silver-haired bats killed per control turbine than at treatment turbines during the treatment period, these only represented an approximate 20% increase in fatality relative to the pre-treatment period for these species when accounting for inherent differences between turbine sets. Our findings suggest broadband ultrasound broadcasts may reduce bat fatalities by discouraging bats from approaching sound sources. However, effectiveness of ultrasonic deterrents is limited by distance and area ultrasound can be broadcast, in part due to rapid attenuation in humid conditions. We caution that an operational deterrent device is not yet available and further modifications and experimentation are needed. Future efforts must also evaluate cost-effectiveness of deterrents in relation to curtailment strategies to allow a cost-benefit analysis for mitigating bat fatalities.

Does Tribolium brevicornis Cuticular Chemistry Deter Cannibalism and Predation of Pupae?

PubMed Central

Alabi, T; Dean, J; Michaud, JP; Verheggen, F; Lognay, G; Haubruge, E

2011-01-01

The cuticular hydrocarbons of insects are species-specific and often function as semiochemicals. The activity of Tribolium brevicornis cuticular hydrocarbons as feeding deterrents that ostensibly function to prevent pupal cannibalism and predation was evaluated. The cuticular hydrocarbons of T. brevicornis pupae were characterized and flour disk bioassays conducted with individual and combined extract components incorporated into artificial diets on which Tribolium adults fed for six days. Feeding by T. brevicornis and T. castaneum on flour disks containing cuticular extracts of T. brevicornis pupae resulted in reduced consumption and weight loss relative to feeding on control flour disks. In both cases, feeding deterrence indices exceeded 80% suggesting that T. brevicornis cuticular hydrocarbons could function to deter cannibalism and predation of pupae by larvae and adult beetles. Sixteen different cuticular hydrocarbons were identified in T. brevicornis pupal extracts. Eight of the commercially available linear alkanes were tested individually in feeding trials with eight Tribolium species. One compound (C28) significantly reduced the amount of food consumed by three species compared to control disks, whereas the compounds C25, C26, and C27 elicited increased feeding in some species. Four other compounds had no effect on consumption for any species. When four hydrocarbon mixtures were tested for synergistic deterrence on T. brevicornis and T. castaneum, none significantly influenced consumption. Our results indicate that the cuticular chemistry of T. brevicornis pupae could serve to deter predation by conspecific and congeneric beetles. PMID:22224957

Operational Vigilant Warrior: Conventional Deterrence Theory, Doctrine, and Practice

DTIC Science & Technology

1996-06-01

psychological aspect of retaliation more than the possibility that defensive actions can deny anticipated gains. This definition is insufficient to...nuclear deterrence, conventional deterrence can also be based on eliminating or limiting the adversary’s ability to act. The nature and destructive...conclusions from the theory and evidence presented in the previous chapters. It reviews how conventional deterrence can be improved by exploiting

Continuous exposure to the deterrents cis-jasmone and methyl jasmonate does not alter the behavioural responses of Frankliniella occidentalis

PubMed Central

Egger, Barbara; Spangl, Bernhard; Koschier, Elisabeth Helene

2016-01-01

Behavioural responses of Frankliniella occidentalis (Pergande) (Thysanoptera: Thripidae), a generalist, cell sap-feeding insect species with piercing-sucking mouthparts, after continuous exposure to two deterrent secondary plant compounds are investigated. We compared in choice assays on bean leaf discs, the settling, feeding, and oviposition preferences of F. occidentalis females that had no experience with the two fatty acid derivatives methyl jasmonate and cis-jasmone before testing (naïve thrips) vs. females that had been exposed to the deterrent compounds before testing (experienced thrips). The thrips were exposed to the deterrents at low or high concentrations for varied time periods and subsequently tested on bean leaf discs treated with the respective deterrent at either a low or a high concentration. Frankliniella occidentalis females avoided settling on the deterrent-treated bean leaf discs for an observation period of 6 h, independent of their previous experience. Our results demonstrate that feeding and oviposition deterrence of the jasmonates to the thrips were not altered by continuous exposure of the thrips to the jasmonates. Habituation was not induced, neither by exposure to the low concentration of the deterrents nor by exposure to the high concentration. These results indicate that the risk of habituation to two volatile deterrent compounds after repeated exposure is not evident in F. occidentalis. This makes the two compounds potential candidates to be integrated in pest management strategies. PMID:26726263

Continuous exposure to the deterrents cis-jasmone and methyl jasmonate does not alter the behavioural responses of Frankliniella occidentalis.

PubMed

Egger, Barbara; Spangl, Bernhard; Koschier, Elisabeth Helene

2016-01-01

Behavioural responses of Frankliniella occidentalis (Pergande) (Thysanoptera: Thripidae), a generalist, cell sap-feeding insect species with piercing-sucking mouthparts, after continuous exposure to two deterrent secondary plant compounds are investigated. We compared in choice assays on bean leaf discs, the settling, feeding, and oviposition preferences of F. occidentalis females that had no experience with the two fatty acid derivatives methyl jasmonate and cis -jasmone before testing (naïve thrips) vs. females that had been exposed to the deterrent compounds before testing (experienced thrips). The thrips were exposed to the deterrents at low or high concentrations for varied time periods and subsequently tested on bean leaf discs treated with the respective deterrent at either a low or a high concentration. Frankliniella occidentalis females avoided settling on the deterrent-treated bean leaf discs for an observation period of 6 h, independent of their previous experience. Our results demonstrate that feeding and oviposition deterrence of the jasmonates to the thrips were not altered by continuous exposure of the thrips to the jasmonates. Habituation was not induced, neither by exposure to the low concentration of the deterrents nor by exposure to the high concentration. These results indicate that the risk of habituation to two volatile deterrent compounds after repeated exposure is not evident in F. occidentalis . This makes the two compounds potential candidates to be integrated in pest management strategies.

Do abuse deterrent opioid formulations work?

PubMed

Dart, Richard C; Iwanicki, Janetta L; Dasgupta, Nabarun; Cicero, Theodore J; Schnoll, Sidney H

We performed a systematic review to answer the question, "Does the introduction of an opioid analgesic with abuse deterrent properties result in reduced overall abuse of the drug in the community?" We included opioid analgesics with abuse deterrent properties (hydrocodone, morphine, oxycodone) with results restricted to the metasearch term "delayed onset," English language, use in humans, and publication years 2009-2016. All articles that contained data evaluating misuse, abuse, overdose, addiction, and death were included. The results were categorized using the Bradford-Hill criteria. We included 44 reports: hydrocodone (n = 7), morphine (n = 5), or oxycodone (n = 32) with Food and Drug Administration-approved Categories 1, 2, or 3 abuse deterrent labeling. The data currently available support the Hill criteria of strength (effect size), consistency (reproducibility), temporality, plausibility, and coherence. There was insufficient or no information available for the criteria of biological gradient, experiment, and analogy. We also assessed confounding factors and bias, which indicated that both were present and substantial in magnitude. Our analysis found that only oxycodone extended release (ER) had information available to evaluate abuse deterrence in the community. In Australia, Canada, and the United States, reformulation of oxycodone ER was followed by marked reduction in measures of abuse. The precise extent of reduced abuse cannot be calculated because of heterogeneous data sets, but the reported reductions ranged from 10 to 90 percent depending on the measure and the duration of follow-up.

Abuse-deterrent formulations, an evolving technology against the abuse and misuse of opioid analgesics.

PubMed

Schaeffer, Tammi

2012-12-01

The increased use of opioid pain medication has been mirrored by the increased misuse and abuse of these drugs. As part of a multidisciplinary approach to this epidemic, pharmaceutical companies, with the encouragement of the Food and Drug Administration, have increased the development of abuse-deterrent formulations. While all have the goal of treating pain while mitigating misuse and abuse, there are different technologies utilized to impart the abuse-deterrent properties. The goal of this paper is to review the basis of abuse-deterrent formulations, the different types and approaches of some of the abuse-deterrent products, and their current regulatory status in the USA.

Routes of abuse of prescription opioid analgesics: a review and assessment of the potential impact of abuse-deterrent formulations.

PubMed

Gasior, Maciej; Bond, Mary; Malamut, Richard

2016-01-01

Prescription opioid analgesics are an important treatment option for patients with chronic pain; however, misuse, abuse and diversion of these medications are a major global public health concern. Prescription opioid analgesics can be abused via intended and non-intended routes of administration, both intact or after manipulation of the original formulation to alter the drug-delivery characteristics. Available data indicate that ingestion (with or without manipulation of the prescribed formulation) is the most prevalent route of abuse, followed by inhalation (snorting, smoking and vaping) and injection. However, reported routes of abuse vary considerably between different formulations. A number of factors have been identified that appear to be associated with non-oral routes of abuse, including a longer duration of abuse, younger age, male sex and a rural or socially deprived location. The development of abuse-deterrent formulations of prescription opioid analgesics is an important step toward reducing abuse of these medications. Available abuse-deterrent formulations aim to hinder extraction of the active ingredient, prevent administration through alternative routes and/or make abuse of the manipulated product less attractive, less rewarding or even aversive. There are currently five opioid analgesics with a Food and Drug Administration abuse-deterrent label, and a number of other products are under review. A growing body of evidence suggests that introduction of abuse-deterrent opioid analgesics in the USA has been associated with decreased rates of abuse of these formulations. The availability of abuse-deterrent formulations therefore appears to represent an important step toward curbing the epidemic of abuse of prescription opioid analgesics, while ensuring the availability of effective pain medications for patients with legitimate medical need.

Important statistical considerations in the evaluation of post-market studies to assess whether opioids with abuse-deterrent properties result in reduced abuse in the community.

PubMed

By, Kunthel; McAninch, Jana K; Keeton, Stephine L; Secora, Alex; Kornegay, Cynthia J; Hwang, Catherine S; Ly, Thomas; Levenson, Mark S

2018-05-01

Abuse, misuse, addiction, overdose, and death associated with non-medical use of prescription opioids have become a serious public health concern. Reformulation of these products with abuse-deterrent properties is one approach for addressing this problem. FDA has approved several extended-release opioid analgesics with abuse-deterrent labeling, the bases of which come from pre-market studies. As all opioid analgesics must be capable of delivering the opioid in order to reduce pain, abuse-deterrent properties do not prevent abuse, nor do pre-market evaluations ensure that there will be reduced abuse in the community. Utilizing data from various surveillance systems, some recent post-market studies suggest a decline in abuse of extended-release oxycodone after reformulation with abuse-deterrent properties. We discuss challenges stemming from the use of such data. We quantify the relationship between the sample, the population, and the underlying sampling mechanism and identify the necessary conditions if valid statements about the population are to be made. The presence of other interventions in the community necessitates the use of comparators. We discuss the principles under which the use of comparators can be meaningful. Results based on surveillance data need to be interpreted with caution as the underlying sampling mechanisms can bias the results in unpredictable ways. The use of comparators has the potential to disentangle the effect due to the abuse-deterrence properties from those due to other interventions. However, identifying a comparator that is meaningful can be very difficult. Published 2017. This article is a U.S. Government work and is in the public domain in the USA.

The deterrent forces of the Commonwealth of Independent States

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kortunov, S.

The rapid changes that are occurring in Europe and in the world at large create qualitatively new military and political realities and will force nuclear powers to make major adjustments in their foreign policy and military-technological thinking. The new situation will certainly lead to changes in both the nuclear doctrines of those countries and their approaches to nuclear forces - both strategic and tactical - as will be needed to ensure national security. This applies fully to the Commonwealth of Independent States (the former USSR), whose nuclear doctrine, like that of the North Atlantic Treaty Organization (NATO), is now beingmore » overhauled. It is well known that the former Soviet Union in its public declarations, including those made at the highest political level, has been strongly critical of the doctrine of deterrence. An unbiased historical analysis of the postwar period also demonstrates that military competition between the Soviet Union and the United States in the nuclear field followed the action-reaction logic, the constraining factors being primarily financial and technological rather than moral. Parity was initially interpreted as numerical equality in strategic nuclear arms and later as rough equality in operational nuclear capabilities. Another confirmation that the Soviet Union had based its policy precisely on the doctrine of deterrence is the Antiballistic Missile (ABM) Treaty, which limits the antiballistic missile systems of the two sides to purely symbolic numbers of ABMs and effectively exposes the former Soviet Union and the United States to a retaliatory strike. Nuclear deterrence is a modus vivendi of the world we live in, and it will stay that way until nations devise a fundamentally new system of maintaining international security. The problem is that the nuclear powers have more than enough nuclear weapons to make deterrence work effectively.« less

New Capabilities for Hostile Environments on Z Grand Challenge LDRD - Final Status

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cuneo, Michael E.; Griffin, P. J.; Balch, D. K.

2016-10-01

The purpose of this project was to develop new physical simulation capabilities in order to support the science-based qualification of nonnuclear weapon components in hostile radiation environments. The project contributes directly to the goals of maintaining a safe, secure, and effective US nuclear stockpile, maintaining strategic deterrence at lower nuclear force levels, extending the life of the nuclear deterrent capability, and to be ready for technological surprise.

The New Era of Counterforce

NASA Astrophysics Data System (ADS)

Lieber, Keir

Nuclear deterrence rests on the survivability of nuclear arsenals. For much of the nuclear age, counterforce disarming attacks those aimed at eliminating nuclear forces were nearly impossible because of the ability of potential victims to hide and protect their weapons. However, technological developments are eroding this foundation of nuclear deterrence. Advances rooted in the computer revolution have made nuclear forces around the world far more vulnerable than before. Specifically, two key approaches that countries have relied on to ensure arsenal survivability since the dawn of the nuclear age hardening and concealment have been undercut by leaps in weapons accuracy and a revolution in remote sensing. Various models, methods, and evidence demonstrate the emergence of new possibilities for counterforce disarming strikes. In short, the task of securing nuclear arsenals against attack is a far greater challenge than it was in the past. The new era of counterforce challenges the basis for confidence in contemporary deterrence stability, raises critical issues for national and international security policy, and sheds light on one of the enduring theoretical puzzles of the nuclear era: why international security competition has endured in the shadow of the nuclear revolution.

Changes in the dispensing of opioid medications in Canada following the introduction of a tamper-deterrent formulation of long-acting oxycodone: a time series analysis.

PubMed

Gomes, Tara; Mastorakos, Andrea; Paterson, J Michael; Sketris, Ingrid; Caetano, Patricia; Greaves, Simon; Henry, David

2017-11-22

In February 2012, a reformulated tamper-deterrent form of long-acting oxycodone, OxyNeo, was introduced in Canada. We investigated the impact of the introduction of OxyNeo on patterns of opioid prescribing. We conducted population-based, cross-sectional analyses of opioid dispensing in Canada between 2008 and 2016. We estimated monthly community pharmacy dispensing of oral formulations of codeine, morphine, hydromorphone and oxycodone, and a transdermal formulation of fentanyl, and converted quantities to milligrams of morphine equivalents (MMEs) per 1000 population. We used time series analysis to evaluate the effect of the introduction of OxyNeo on these trends. National dispensing of long-acting opioids fell by 14.9% between February 2012 and April 2016, from 36 098 MMEs to 30 716 MMEs per 1000 population ( p < 0.01). This effect varied across Canada and was largest in Ontario (reduction of 22.8%) ( p = 0.01) and British Columbia (reduction of 30.0%) ( p = 0.01). The national rate of oxycodone dispensing fell by 46.4% after the introduction of OxyNeo ( p < 0.001); this was partially offset by an increase of 47.8% in hydromorphone dispensing ( p < 0.001). Although dispensing of immediate-release opioids was a substantial contributor to overall population opioid exposure across Canada, it was unaffected by the introduction of OxyNeo ( p > 0.05 in all provinces). The findings suggest that the introduction of a tamper-deterrent formulation of long-acting oxycodone in Canada, against a background of changing public drug benefits, was associated with sustained changes in selection of long-acting opioids but only small changes in the quantity of long-acting opioids dispensed. This illustrates the limited effect a tamper-deterrent formulation and associated coverage policy can have when other, non-tamper-deterrent alternatives are readily available. Copyright 2017, Joule Inc. or its licensors.

On sanction-goal justifications: How and why deterrence justifications undermine rule compliance.

PubMed

Mooijman, Marlon; van Dijk, Wilco W; van Dijk, Eric; Ellemers, Naomi

2017-04-01

Authorities frequently justify their sanctions as attempts to deter people from rule breaking. Although providing a sanction justification seems appealing and harmless, we propose that a deterrence justification decreases the extent to which sanctions are effective in promoting rule compliance. We develop a theoretical model that specifies how and why this occurs. Consistent with our model, 5 experiments demonstrated that-compared with sanctions provided without a justification or sanctions provided with a just-deserts justification-sanction effectiveness decreased when sanctions were justified as attempts to deter people from rule breaking. This effect was mediated by people feeling distrusted by the authority. We further demonstrated that (a) the degree to which deterrence fostered distrust was attenuated when the sanction was targeted at others (instead of the participant) and (b) the degree to which distrust undermined rule compliance was attenuated when the authority was perceived as legitimate. We discuss the practical implications for authorities tasked with promoting rule compliance, and the theoretical implications for the literature on sanctions, distrust, and rule compliance. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Ethical dilemmas of nuclear deterrence

DOE Office of Scientific and Technical Information (OSTI.GOV)

Russett, B.M.

An analysis of the May 1983 Pastoral Letter on War and Peace of the US Catholic Bishops examines their ethical arguments, which were critical of accepted policy while failing to change the underlying principles of acceptable deterrence and a just war. The author concludes that there is no easy solution to the problem of nuclear deterrence because there is no way to bridge the extremes of war-winning counterforce and possession without use. The Bishops' central problem was deterrence of attack on US allies or neutrals, but he finds merit in their positions that deterrence need not rely on nuclear threatsmore » and that new ways of thinking are needed for the long run. 20 references. (DCK)« less

Deterrents to Accountability.

ERIC Educational Resources Information Center

Hencley, Stephen P.

This speech assesses potential deterrents to the implementation of accountability in education. The author divides these deterrents into (1) philosophical-ideological; humanist-behaviorist conflicts, individuality versus "techno-urban fascism," and accountability systems tied to the achievement of cognitive objectives at the lower end of Bloom's…

Trends in reports of driving following illicit drug consumption among regular drug users in Australia, 2007-2013: Has random roadside drug testing had a deterrent effect?

PubMed

Horyniak, Danielle; Dietze, Paul; Lenton, Simon; Alati, Rosa; Bruno, Raimondo; Matthews, Allison; Breen, Courtney; Burns, Lucy

2017-07-01

Driving following illicit drug consumption ('drug-driving') is a potential road safety risk. Roadside drug testing (RDT) is conducted across Australia with the dual aims of prosecuting drivers with drugs in their system and deterring drug-driving. We examined trends over time in self-reported past six-month drug-driving among sentinel samples of regular drug users and assessed the impact of experiences of RDT on drug-driving among these participants. Data from 1913 people who inject drugs (PWID) and 3140 regular psychostimulant users (RPU) who were first-time participants in a series of repeat cross-sectional sentinel studies conducted in Australian capital cities from 2007 to 2013 and reported driving in the past six months were analysed. Trends over time were assessed using the χ 2 test for trend. Multivariable logistic regressions assessed the relationship between experiences of RDT and recent drug-driving, adjusting for survey year, jurisdiction of residence and socio-demographic and drug use characteristics. The percentage of participants reporting recent (past six months) drug-driving decreased significantly over time among both samples (PWID: 83% [2007] vs. 74% [2013], p<0.001; RPU: 72% vs. 56%, p<0.001), but drug-driving remained prevalent. Lifetime experience of RDT increased significantly over time (PWID: 6% [2007] vs. 32% [2013], p<0.001; RPU: 2% vs. 11%, p<0.001). There were no significant associations between experiencing RDT and drug-driving among either PWID or RPU. Although there is some evidence that drug-driving among key risk groups of regular drug users is declining in Australia, possibly reflecting a general deterrent effect of RDT, experiencing RDT appears to have no specific deterrent effect on drug-driving. Further intervention, with a particular focus on changing attitudes towards drug-driving, may be needed to further reduce this practice among these groups. Copyright © 2017 Elsevier Ltd. All rights reserved.

Deterrence by Denial: The Efficacy of U.S. Missile Defense in the Persian Gulf as a Deterrent Against the Iranian Regional Missile Threat

DTIC Science & Technology

2011-06-10

me throughout the entire process. Your professionalism and guidance were critical in making this a worthwhile study. Special thanks to my wife Jamie ...intelligence review by Michael Knights entitled ―Deterrence by punishment could offer last resort options for Iran‖ in April 2006. In this report, Knights ...RL32048, Iran: U.S. Concerns and Policy Responses. Washington, DC: Congressional Research Service, 20 August 2010. Knights , Michael. ―Deterrence by

Examining deterrence of adult sex crimes: A semi-parametric intervention time series approach.

PubMed

Park, Jin-Hong; Bandyopadhyay, Dipankar; Letourneau, Elizabeth

2014-01-01

Motivated by recent developments on dimension reduction (DR) techniques for time series data, the association of a general deterrent effect towards South Carolina (SC)'s registration and notification (SORN) policy for preventing sex crimes was examined. Using adult sex crime arrestee data from 1990 to 2005, the the idea of Central Mean Subspace (CMS) is extended to intervention time series analysis (CMS-ITS) to model the sequential intervention effects of 1995 (the year SC's SORN policy was initially implemented) and 1999 (the year the policy was revised to include online notification) on the time series spectrum. The CMS-ITS model estimation was achieved via kernel smoothing techniques, and compared to interrupted auto-regressive integrated time series (ARIMA) models. Simulation studies and application to the real data underscores our model's ability towards achieving parsimony, and to detect intervention effects not earlier determined via traditional ARIMA models. From a public health perspective, findings from this study draw attention to the potential general deterrent effects of SC's SORN policy. These findings are considered in light of the overall body of research on sex crime arrestee registration and notification policies, which remain controversial.

Testing the effectiveness of an acoustic deterrent for gray whales along the Oregon coast

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lagerquist, Barbara; Winsor, Martha; Mate, Bruce

This study was conducted to determine whether a low-powered sound source could be effective at deterring gray whales from areas that may prove harmful to them. With increased interest in the development of marine renewal energy along the Oregon coast the concern that such development may pose a collision or entanglement risk for gray whales. A successful acoustic deterrent could act as a mitigation tool to prevent harm to whales from such risks. In this study, an acoustic device was moored on the seafloor in the pathway of migrating gray whales off Yaquina Head on the central Oregon coast. Shore-basedmore » observers tracked whales with a theodolite (surveyor’s tool) to accurately locate whales as they passed the headland. Individual locations of different whales/whale groups as well as tracklines of the same whale/whale groups were obtained and compared between times with the acoustic device was transmitting and when it was off. Observations were conducted on 51 d between January 1 and April 15, 2012. A total of 143 individual whale locations were collected for a total of 243 whales, as well as 57 tracklines for a total of 142 whales. Inclement weather and equipment problems resulted in very small sample sizes, especially during experimental periods, when the device was transmitting. Because of this, the results of this study were inconclusive. We feel that another season of field testing is warranted to successfully test the effectiveness of the deterrent, but recommend increasing the zone of influence to 3 km to ensure the collection of adequate sample sizes. Steps have been taken to acquire the necessary federal research permit modification to authorize the increased zone of influence and to modify the acoustic device for the increased power. With these changes we are confident we will be able to determine whether the deterrent is effective at deflecting gray whales. A successful deterrent device may serve as a valuable mitigation tool to protect gray whales, and other baleen whales, in the event that marine energy development poses a collision or entanglement risk.« less

Water-Borne Cues of a Non-Indigenous Seaweed Mediate Grazer-Deterrent Responses in Native Seaweeds, but Not Vice Versa

PubMed Central

Yun, Hee Young; Engelen, Aschwin H.; Santos, Rui O.; Molis, Markus

2012-01-01

Plants optimise their resistance to herbivores by regulating deterrent responses on demand. Induction of anti-herbivory defences can occur directly in grazed plants or from emission of risk cues to the environment, which modifies interactions of adjacent plants with, for instance, their consumers. This study confirmed the induction of anti-herbivory responses by water-borne risk cues between adjoining con-specific seaweeds and firstly examined whether plant-plant signalling also exists among adjacent hetero-specific seaweeds. Furthermore, differential abilities and geographic variation in plant-plant signalling by a non-indigenous seaweed as well as native seaweeds were assessed. Twelve-day induction experiments using the non-indigenous seaweed Sargassum muticum were conducted in the laboratory in Portugal and Germany with one local con-familiar (Portugal: Cystoseira humilis, Germany: Halidrys siliquosa) and hetero-familiar native species (Portugal: Fucus spiralis, Germany: F. vesiculosus). All seaweeds were grazed by a local isopod species (Portugal: Stenosoma nadejda, Germany: Idotea baltica) and were positioned upstream of con- and hetero-specific seaweeds. Grazing-induced modification in seaweed traits were tested in three-day feeding assays between cue-exposed and cue-free ( = control) pieces of both fresh and reconstituted seaweeds. Both Fucus species reduced their palatability when positioned downstream of isopod-grazed con-specifics. Yet, the palatability of non-indigenous S. muticum remained constant in the presence of upstream grazed con-specifics and native hetero-specifics. In contrast, both con-familiar (but neither hetero-familiar) native species reduced palatability when located downstream of grazed S. muticum. Similar patterns of grazer-deterrent responses to water-borne cues were observed on both European shores, and were almost identical between assays using fresh and reconstituted seaweeds. Hence, seaweeds may use plant-plant signalling to optimise chemical resistance to consumers, though this ability appeared to be species-specific. Furthermore, this study suggests that native species may benefit more than a non-indigenous species from water-borne cue mediated reduction in consumption as only natives responded to signals emitted by hetero-specifics. PMID:22701715

Water-borne cues of a non-indigenous seaweed mediate grazer-deterrent responses in native seaweeds, but not vice versa.

PubMed

Yun, Hee Young; Engelen, Aschwin H; Santos, Rui O; Molis, Markus

2012-01-01

Plants optimise their resistance to herbivores by regulating deterrent responses on demand. Induction of anti-herbivory defences can occur directly in grazed plants or from emission of risk cues to the environment, which modifies interactions of adjacent plants with, for instance, their consumers. This study confirmed the induction of anti-herbivory responses by water-borne risk cues between adjoining con-specific seaweeds and firstly examined whether plant-plant signalling also exists among adjacent hetero-specific seaweeds. Furthermore, differential abilities and geographic variation in plant-plant signalling by a non-indigenous seaweed as well as native seaweeds were assessed. Twelve-day induction experiments using the non-indigenous seaweed Sargassum muticum were conducted in the laboratory in Portugal and Germany with one local con-familiar (Portugal: Cystoseira humilis, Germany: Halidrys siliquosa) and hetero-familiar native species (Portugal: Fucus spiralis, Germany: F. vesiculosus). All seaweeds were grazed by a local isopod species (Portugal: Stenosoma nadejda, Germany: Idotea baltica) and were positioned upstream of con- and hetero-specific seaweeds. Grazing-induced modification in seaweed traits were tested in three-day feeding assays between cue-exposed and cue-free ( = control) pieces of both fresh and reconstituted seaweeds. Both Fucus species reduced their palatability when positioned downstream of isopod-grazed con-specifics. Yet, the palatability of non-indigenous S. muticum remained constant in the presence of upstream grazed con-specifics and native hetero-specifics. In contrast, both con-familiar (but neither hetero-familiar) native species reduced palatability when located downstream of grazed S. muticum. Similar patterns of grazer-deterrent responses to water-borne cues were observed on both European shores, and were almost identical between assays using fresh and reconstituted seaweeds. Hence, seaweeds may use plant-plant signalling to optimise chemical resistance to consumers, though this ability appeared to be species-specific. Furthermore, this study suggests that native species may benefit more than a non-indigenous species from water-borne cue mediated reduction in consumption as only natives responded to signals emitted by hetero-specifics.

Age differences in understanding precedent-setting decisions and authorities' responses to violations of deontic rules.

PubMed

Klaczynski, Paul A

2011-05-01

To examine age trends in precedent-setting decisions and the effects of these decisions on perceptions of authorities, preadolescents and adolescents were presented with deontic rule infractions that occurred in the absence or presence of mitigating circumstances. In Study 1, in the absence of mitigating circumstances, adolescents recommended punishing rule violations more than preadolescents; when mitigating circumstances were present, adolescents recommended punishing infractions less than preadolescents. In Study 2, before and after receiving information that authorities had punished or permitted rule violations, participants indicated their beliefs in authority legitimacy, rule strength, and rule deterrence value. In the absence of mitigating circumstances, beliefs strengthened when infractions were punished and beliefs weakened when infractions were permitted. When mitigating circumstances were present and authorities punished violations, preadolescents' legitimacy and deterrence beliefs strengthened. Adolescents' deterrence beliefs strengthened, but their beliefs in authority legitimacy weakened. When justifiable infractions were permitted, preadolescents' legitimacy and deterrence beliefs weakened, whereas adolescents' beliefs strengthened. Discussion focuses on age differences in legitimacy beliefs and understanding the consequences of setting precedents and on the relevance of the findings to theories of deontic reasoning, moral judgments, and epistemological development. Copyright © 2010 Elsevier Inc. All rights reserved.

Sources of Deterrence: The Perceived Costs of Assault Versus Arrest.

ERIC Educational Resources Information Center

Hawkins, Richard; Williams, Kirk R.

Recent panel studies of deterrence have reported little evidence that perceptions of legal sanctions promote deterrence. Yet those studies have consistently found that extralegal sanctions "inhibit" criminal involvement. Conclusions drawn from this line of research remain speculative, however, because they are guided by an unnecessarily…

Rats and seabirds: effects of egg size on predation risk and the potential of conditioned taste aversion as a mitigation method.

PubMed

Latorre, Lucía; Larrinaga, Asier R; Santamaría, Luis

2013-01-01

Seabirds nesting on islands are threatened by invasive rodents, such as mice and rats, which may attack eggs, chicks and even adults. The low feasibility of rat eradications on many islands makes the development of alternate control plans necessary. We used a combination of field experiments on a Mediterranean island invaded by black rats (Rattusrattus) to evaluate (1) the predation risk posed to different-sized seabird eggs and (2), the potential of two deterrent methods (electronic and chemical) to reduce its impact. Rats were able to consume eggs of all sizes (12 to 68 g), but survival increased 13 times from the smallest to the largest eggs (which also had more resistant eggshells). Extrapolation to seabird eggs suggests that the smallest species (Hydrobatespelagicus) suffer the most severe predation risk, but even the largest (Larusmichahellis) could suffer >60% mortality. Nest attack was not reduced by the deterrents. However, chemical deterrence (conditioned taste aversion by lithium chloride) slowed the increase in predation rate over time, which resulted in a three-fold increase in egg survival to predation as compared to both control and electronic deterrence. At the end of the experimental period, this effect was confirmed by a treatment swap, which showed that conferred protection remains at least 15 days after cessation of the treatment. Results indicate that small seabird species are likely to suffer severe rates of nest predation by rats and that conditioned taste aversion, but not electronic repellents, may represent a suitable method to protect colonies when eradication or control is not feasible or cost-effective.

Production, perceptions, and punishment: restrictive deterrence in the context of cannabis cultivation.

PubMed

Nguyen, Holly; Malm, Aili; Bouchard, Martin

2015-03-01

American authorities have invested extraordinary resources to keep up with the growth in cannabis cultivation, and state-level cannabis laws have been changing rapidly. Despite these changes, little research on the relationship between criminal justice sanctions and grower behaviours exist, in particular research that examines restrictive deterrence - the altering of an illegal behaviour as opposed to desisting from it completely. We examine restrictive deterrence in the context of cannabis cultivation by modelling the relationship between the threat of sanctions and the size of cultivation site and number of co-offenders. We use data from an anonymous web survey where participants were recruited through advertisements on websites related to cannabis use and cultivation. Negative binomial regression were used on 337 cases that contain valid data on size of cultivation site and 338 cases that contain valid data on the number of co-offenders. Our study found some evidence that the severity of state sanctions reduces the size of cultivation sites among growers who reside in the state. However, the number of contacts with the police had the opposite effect. In addition, we did not find a restrictive deterrent effect for the number of co-offenders, suggesting that different factors affect different decision points. Interestingly, objective skill and subjective skill had positive and independent effects on size of site. Results suggest that state-level sanctions have a structuring effect by restricting the size of cultivation sites but further increases in sanctions or enforcement are unlikely to deter more individuals from growing cannabis. In fact, there may be some potential dangers of increased enforcement on cannabis growers. Copyright © 2014 Elsevier B.V. All rights reserved.

Employment of physical therapist assistants in a residential state school.

PubMed

Lovelace-Chandler, V; Lovelace-Chandler, B

1979-10-01

Development of a job description for physical therapist assistants in a residential center serving persons with developmental disabilities is presented. Academic preparation and ethical guidelines for the assistant were reviewed to determine appropriate job responsibilities. Assistants had sufficient academic preparation in modalities and bronchial drainage to function effectively and partial academic preparation in other areas related to treating developmental disabilities. Substantial on-the-job training was necessary for the assistant to perform specific tasks competently. Need for additional training was not considered a deterrent to hiring the assistant.

The nuclear debate: Deterrence and the lapse of faith

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tucker, R.W.

1985-01-01

This essay examines the growth of skepticism about the present system of nuclear deterrence. Tucker resists predicting the ultimate outcome, but he views the nuclear debate of this decade as an important ''lapse of faith'' in deterrence and he doubts there will ever be a full restoration of confidence.

Defining Deterrence in Cyberspace Working Toward a Framework to Integrate Cyber Deterrence

DTIC Science & Technology

2011-04-01

The goal of deterrence is not to deter the use of a particular weapon. Rather, a nation deters undesirable behavior. Cyber warfare can produce three...associated limitations will not produce a strategically decisive result. Cyber warfare must be used in conjunction with other instruments of power to

Malpractice litigation and nursing home quality of care.

PubMed

Konetzka, R Tamara; Park, Jeongyoung; Ellis, Robert; Abbo, Elmer

2013-12-01

To assess the potential deterrent effect of nursing home litigation threat on nursing home quality. We use a panel dataset of litigation claims and Nursing Home Online Survey Certification and Reporting (OSCAR) data from 1995 to 2005 in six states: Florida, Illinois, Wisconsin, New Jersey, Missouri, and Delaware, for a total of 2,245 facilities. Claims data are from Westlaw's Adverse Filings database, a proprietary legal database, on all malpractice, negligence, and personal injury/wrongful death claims filed against nursing facilities. A lagged 2-year moving average of the county-level number of malpractice claims is used to represent the threat of litigation. We use facility fixed-effects models to examine the relationship between the threat of litigation and nursing home quality. We find significant increases in registered nurse-to-total staffing ratios in response to rising malpractice threat, and a reduction in pressure sores among highly staffed facilities. However, the magnitude of the deterrence effect is small. Deterrence in response to the threat of malpractice litigation is unlikely to lead to widespread improvements in nursing home quality. This should be weighed against other benefits and costs of litigation to assess the net benefit of tort reform. © Health Research and Educational Trust.

Global 93: Deterrence Theory for the Coming Decade

DTIC Science & Technology

1993-06-30

likely to create in the near future. They will not create contingencies in which U.S. power is a relevant deterrent." Raj Krishna , "India and the Bomb...Obsolescence of MaiorWar (New York: Basic Books, 1989) Naroll, Raoul, Vern L. Bullough, and Frada Naroll, Military Deterrence in History (Albany: State

An evaluation of mosquito repellents and essential plant oils as deterrents of Asian citrus psyllid

USDA-ARS?s Scientific Manuscript database

This study objectives were to evaluate mosquito repellents against Asian citrus psyllid (ACP) and to expand our knowledge of the potential of essential plant oils as deterrents of adult infestations. Twenty-two candidate deterrents were tested as 20% solutions in methanol using a laboratory assay. G...

Research design considerations for clinical studies of abuse-deterrent opioid analgesics: IMMPACT recommendations

PubMed Central

Turk, Dennis C.; O’Connor, Alec B.; Dworkin, Robert H.; Chaudhry, Amina; Katz, Nathaniel P.; Adams, Edgar H.; Brownstein, John S.; Comer, Sandra D.; Dart, Richard; Dasgupta, Nabarun; Denisco, Richard A.; Klein, Michael; Leiderman, Deborah B.; Lubran, Robert; Rappaport, Bob A.; Zacny, James P.; Ahdieh, Harry; Burke, Laurie B.; Cowan, Penney; Jacobs, Petra; Malamut, Richard; Markman, John; Michna, Edward; Palmer, Pamela; Peirce-Sandner, Sarah; Potter, Jennifer S.; Raja, Srinivasa N.; Rauschkolb, Christine; Roland, Carl L.; Webster, Lynn R.; Weiss, Roger D.; Wolf, Kerry

2013-01-01

Opioids are essential to the management of pain in many patients, but they also are associated with potential risks for abuse, overdose, and diversion. A number of efforts have been devoted to the development of abuse-deterrent formulations of opioids to reduce these risks. This article summarizes a consensus meeting that was organized to propose recommendations for the types of clinical studies that can be used to assess the abuse deterrence of different opioid formulations. Due to the many types of individuals who may be exposed to opioids, an opioid formulation will need to be studied in several populations using various study designs in order to determine its abuse-deterrent capabilities. It is recommended that the research conducted to evaluate abuse deterrence should include studies assessing: (1) abuse liability; (2) the likelihood that opioid abusers will find methods to circumvent the deterrent properties of the formulation; (3) measures of misuse and abuse in randomized clinical trials involving pain patients with both low risk and high risk of abuse; and (4) post-marketing epidemiological studies. PMID:22770841

Deficiency of gustatory sensitivity to some deterrent compounds in "polyphagous" mutant strains of the silkworm, Bombyx mori.

PubMed

Asaoka, K

2000-11-01

Sawa-J, CSJ02 and N601 x C601 are selected mutant strains of Bombyx mori, which grow on various artificial diets or temporarily ingest various plant leaves. To examine the mechanisms mediating diet breadth of caterpillars, gustatory spike responses of the silkworms, called 'polyphagous" strains, were compared with normal strains, N137 x C146 and C02. There were notable differences in their feeding habits and in their sensitivity to salicin in deterrent cells in the maxillary medial styloconic sensilla and the epipharyngeal sensilla. By contrast, the deterrent cells of all strains responded similarly to strychnine nitrate in a dose-dependent manner. In additional comparisons of Sawa-J and N137 x C146, Sawa-J maxillary deterrent cells were significantly less sensitive to phloridzin, amygdalin and arbutin, but responded to some alkaloids and 20-hydroxyecdysone with similar or even higher firing rate. These results suggest that the deficiency of the sensitivity to some deterrent compounds on the deterrent cell of the polyphagous strains may be caused by mutant genes and affects the diet breadth of caterpillars.

The value of vengeance and the demand for deterrence.

PubMed

Crockett, Molly J; Özdemir, Yagiz; Fehr, Ernst

2014-12-01

Humans will incur costs to punish others who violate social norms. Theories of justice highlight 2 motives for punishment: a forward-looking deterrence of future norm violations and a backward-looking retributive desire to harm. Previous studies of costly punishment have not isolated how much people are willing to pay for retribution alone, because typically punishment both inflicts damage (satisfying the retributive motive) and communicates a norm violation (satisfying the deterrence motive). Here, we isolated retributive motives by examining how much people will invest in punishment when the punished individual will never learn about the punishment. Such "hidden" punishment cannot deter future norm violations but was nevertheless frequently used by both 2nd-party victims and 3rd-party observers of norm violations, indicating that retributive motives drive punishment decisions independently from deterrence goals. While self-reports of deterrence motives correlated with deterrence-related punishment behavior, self-reports of retributive motives did not correlate with retributive punishment behavior. Our findings reveal a preference for pure retribution that can lead to punishment without any social benefits. PsycINFO Database Record (c) 2014 APA, all rights reserved.

The Value of Vengeance and the Demand for Deterrence

PubMed Central

2014-01-01

Humans will incur costs to punish others who violate social norms. Theories of justice highlight 2 motives for punishment: a forward-looking deterrence of future norm violations and a backward-looking retributive desire to harm. Previous studies of costly punishment have not isolated how much people are willing to pay for retribution alone, because typically punishment both inflicts damage (satisfying the retributive motive) and communicates a norm violation (satisfying the deterrence motive). Here, we isolated retributive motives by examining how much people will invest in punishment when the punished individual will never learn about the punishment. Such “hidden” punishment cannot deter future norm violations but was nevertheless frequently used by both 2nd-party victims and 3rd-party observers of norm violations, indicating that retributive motives drive punishment decisions independently from deterrence goals. While self-reports of deterrence motives correlated with deterrence-related punishment behavior, self-reports of retributive motives did not correlate with retributive punishment behavior. Our findings reveal a preference for pure retribution that can lead to punishment without any social benefits. PMID:25285429

Blunt impact as deterrent: human approach-avoidance behaviors and other stress responses studied within a paintball gaming context

NASA Astrophysics Data System (ADS)

Short, Kenneth R.; Bergen, Michael T.; DeMarco, Robert M.; Chua, Florence B.; Servatius, Richard J.

2006-05-01

Blunt impact munitions are often used by civilian law enforcement and in military operations on urban terrain (MOUT) missions to dissuade individuals and groups from approaching valued assets. The use of blunt munitions (rubber-ball or sponge) is predicated on their effectiveness as aversive stimuli; the effectiveness is weighed against the risk of serious injury or death. However, little empirical evidence supports effectiveness. Here, we use a paintball gaming context to study the effects of blunt impact on performance and approach behaviors. Volunteers individually traversed a course in which targets offer the opportunity to gain for accuracy. While completing the targeting task, subjects were bombarded with paintballs, which progressively became more numerous and the impact more intense as the subjects neared goal locations. Initial data suggest that over 30 blunt impacts by paintballs delivered at 280 ft/sec over 30 to 100 ft are insufficient to overcome intrinsic and extrinsic approach motivations or impair targeting or advance performance in an overwhelming majority of subjects. Our apparent ceiling effect was surprising. A sub-comparison of the few subjects who stopped the game before the end with those who did not suggests that personality factors influence the effectiveness of blunt impact as a deterrent. While paintballs differ from traditional blunt impact munitions on a number of physical characteristics, impact that was sufficient to repeatedly bruise volunteers was not an effective deterrent.

An experimental hut study to quantify the effect of DDT and airborne pyrethroids on entomological parameters of malaria transmission

PubMed Central

2014-01-01

Background Current malaria vector control programmes rely on insecticides with rapid contact toxicity. However, spatial repellents can also be applied to reduce man-vector contact, which might ultimately impact malaria transmission. The aim of this study was to quantify effects of airborne pyrethroids from coils and DDT used an indoor residual spray (IRS) on entomological parameters that influence malaria transmission. Methods The effect of Transfluthrin and Metofluthrin coils compared to DDT on house entry, exit and indoor feeding behaviour of Anopheles gambiae sensu lato were measured in experimental huts in the field and in the semi-field. Outcomes were deterrence - reduction in house entry of mosquitoes; irritancy or excito-repellency – induced premature exit of mosquitoes; blood feeding inhibition and effect on mosquito fecundity. Results Transfluthrin coils, Metofluthrin coils and DDT reduced human vector contact through deterrence by 38%, 30% and 8%, respectively and induced half of the mosquitoes to leave huts before feeding (56%, 55% and 48%, respectively). Almost all mosquitoes inside huts with Metofluthrin and Transfluthrin coils and more than three quarters of mosquitoes in the DDT hut did not feed, almost none laid eggs and 67%, 72% and 70% of all mosquitoes collected from Transfluthrin, Metofluthrin and DDT huts, respectively had died after 24 hours. Conclusion This study highlights that airborne pyrethroids and DDT affect a range of anopheline mosquito behaviours that are important parameters in malaria transmission, namely deterrence, irritancy/excito-repellency and blood-feeding inhibition. These effects are in addition to significant toxicity and reduced mosquito fecundity that affect mosquito densities and, therefore, provide community protection against diseases for both users and non-users. Airborne insecticides and freshly applied DDT had similar effects on deterrence, irritancy and feeding inhibition. Therefore, it is suggested that airborne pyrethroids, if delivered in suitable formats, may complement existing mainstream vector control tools. PMID:24693934

Mechanisms of Feeding Deterrence by Ziziphins.

DTIC Science & Technology

1985-05-30

number) e mechanism of feeding deterrence by ziziphins for sout rn armyworms ( Spodoptera eridania ; Lepidoptera:Noctuidae) was investigated using bo long... Spodoptera eridania , to investigate the mechanisms of feeding deterrence by ziziphins extracted from the leaves of • .Ziziphus jujuba. Evaluation...Videotape Analysis of Feeding Suppression in the Southern Armyworm ( Spodoptera eridania ; Lepidoptera: Noctuidae) Produced by Extracts of the

Cracks in the New Jar: The Limits of Tailored Deterrence

DTIC Science & Technology

2011-03-17

motivated biases, which result from subconscious psychological pressure that distorts perception. Motivated biases differ from cognitive biases...deterrence theory, including the uncertainty and cognitive biases inherent to both intelligence assessments and international relations. While...neglects some of the most important elements of contemporary deterrence theory, including the uncertainty and cognitive biases inherent to both

Feeding and oviposition deterrent activities of flower buds of globemallow,Sphaeralcea emoryi torrey, against boll weevil,Anthonomus grandis Boheman (Coleoptera: Curculionidae).

PubMed

Honda, H; Bowers, W S

1996-01-01

The globemallow,Sphaeralcea emoryi Torrey, a plant native to Arizona was evaluated as a source of feeding or oviposition deterrents to the boll weevil,Anthonomus grandis Boheman. Feeding and oviposition responses of reproductive weevils to the flower buds and artificial diets spiked with dry powder or extracts of the globemallow buds were determined. Boll weevils were deterred from feeding and ovipositing in the flower buds unless the calyxes were removed. Male and virgin female weevils were discouraged from feeding as much as gravid weevils. Secondary chemicals in the flower buds served primarily as feeding deterrents but also prevented oviposition. The concentration of these chemicals was highest in the calyxes of the buds, and potent deterrent activity could be extracted from the calyxes with methanol. Boll weevils were able to perceive the deterrents by contact chemosensory organs on the antennae, maxillary palps and labial palps.

Los Alamos National Laboratory Human and Intellectual Capital for Sustaining Nuclear Deterrence

DOE Office of Scientific and Technical Information (OSTI.GOV)

McAlpine, Bradley

2015-04-01

This paper provides an overview of the current human and intellectual capital at Los Alamos National Laboratory, through specific research into the statistics and demographics as well as numerous personal interviews at all levels of personnel. Based on this information, a series of recommendations are provided to assist Los Alamos National Laboratory in ensuring the future of the human and intellectual capital for the nuclear deterrence mission. While the current human and intellectual capital is strong it stands on the precipice and action must be taken to ensure Los Alamos National Laboratory maintains leadership in developing and sustaining national nuclearmore » capabilities. These recommendations may be applicable to other areas of the nuclear enterprise, including the Air Force, after further research and study.« less

Increasing Uncertainty: The Dangers of Relying on Conventional Forces for Nuclear Deterrence

DTIC Science & Technology

2016-03-14

designed by the United States to meet its nuclear deterrence needs are not constrained by the “nuclear taboo ” and, in fact, are more usable.38 The...Nuclear deterrence may be much more fragile than any of us realize. It is imperative that we do not take the “nuclear taboo ” for granted by assuming

A Cross-Cultural Study of Punishment Beliefs and Decisions.

PubMed

Zhang, Yanyan; Chen, Chuansheng; Greenberger, Ellen; Knowles, Eric D

2017-02-01

The current research examined cultural similarities and differences in punishment beliefs and decisions. Participants were European Americans ( N = 50), Chinese Americans ( N = 57), and Chinese in Mainland China ( N = 50). The Functions of Punishment Questionnaire was used to measure participants' beliefs about the retributive or deterrent functions of punishment and a scenario method was used to measure the extent to which punishment decisions were driven by individuals' concerns for retribution or deterrence. The results indicated that, contrary to the hypothesis that the retributive function would be emphasized by individualistic groups and the deterrent function by collectivistic groups, Mainland Chinese participants had a stronger belief in retribution and a weaker belief in deterrence than did European and Chinese Americans. The results also indicated that retribution played a bigger role in punishment decisions for Chinese than for the other two groups, but the importance of the deterrence function in punishment decisions did not differ across the three groups. Finally, the correlation between interdependence orientation and the belief in retribution was positive for Chinese but negative for European Americans. Taken together, the findings provided little evidence that collectivists are more deterrence-oriented and individualists more retribution-oriented.

Research design considerations for clinical studies of abuse-deterrent opioid analgesics: IMMPACT recommendations.

PubMed

Turk, Dennis C; O'Connor, Alec B; Dworkin, Robert H; Chaudhry, Amina; Katz, Nathaniel P; Adams, Edgar H; Brownstein, John S; Comer, Sandra D; Dart, Richard; Dasgupta, Nabarun; Denisco, Richard A; Klein, Michael; Leiderman, Deborah B; Lubran, Robert; Rappaport, Bob A; Zacny, James P; Ahdieh, Harry; Burke, Laurie B; Cowan, Penney; Jacobs, Petra; Malamut, Richard; Markman, John; Michna, Edward; Palmer, Pamela; Peirce-Sandner, Sarah; Potter, Jennifer S; Raja, Srinivasa N; Rauschkolb, Christine; Roland, Carl L; Webster, Lynn R; Weiss, Roger D; Wolf, Kerry

2012-10-01

Opioids are essential to the management of pain in many patients, but they also are associated with potential risks for abuse, overdose, and diversion. A number of efforts have been devoted to the development of abuse-deterrent formulations of opioids to reduce these risks. This article summarizes a consensus meeting that was organized to propose recommendations for the types of clinical studies that can be used to assess the abuse deterrence of different opioid formulations. Because of the many types of individuals who may be exposed to opioids, an opioid formulation will need to be studied in several populations using various study designs to determine its abuse-deterrent capabilities. It is recommended that the research conducted to evaluate abuse deterrence should include studies assessing: (1) abuse liability, (2) the likelihood that opioid abusers will find methods to circumvent the deterrent properties of the formulation, (3) measures of misuse and abuse in randomized clinical trials involving pain patients with both low risk and high risk of abuse, and (4) postmarketing epidemiological studies. Copyright © 2012 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

What Deters Crime? Comparing the Effectiveness of Legal, Social, and Internal Sanctions Across Countries.

PubMed

Mann, Heather; Garcia-Rada, Ximena; Hornuf, Lars; Tafurt, Juan

2016-01-01

The question of what deters crime is of both theoretical and practical interest. The present paper focuses on what factors deter minor, non-violent crimes, i.e., dishonest actions that violate the law. Much research has been devoted to testing the effectiveness of legal sanctions on crime, while newer models also include social sanctions (judgment of friends or family) and internal sanctions (feelings of guilt). Existing research suggests that both internal sanctions and, to a lesser extent, legal sanctions deter crime, but it is unclear whether this pattern is unique to Western countries or robust across cultures. We administered a survey study to participants in China, Colombia, Germany, Portugal, and USA, five countries from distinct cultural regions of the world. Participants were asked to report the likelihood of engaging in seven dishonest and illegal actions, and were asked to indicate the probability and severity of consequences for legal, friend, family, and internal sanctions. Results indicated that across countries, internal sanctions had the strongest deterrent effects on crime. The deterrent effects of legal sanctions were weaker and varied across countries. Furthermore, the deterrent effects of legal sanctions were strongest when internal sanctions were lax. Unexpectedly, social sanctions were positively related to likelihood of engaging in crime. Taken together, these results suggest that the relative strengths of legal and internal sanctions are robust across cultures and dishonest actions.

What Deters Crime? Comparing the Effectiveness of Legal, Social, and Internal Sanctions Across Countries

PubMed Central

Mann, Heather; Garcia-Rada, Ximena; Hornuf, Lars; Tafurt, Juan

2016-01-01

The question of what deters crime is of both theoretical and practical interest. The present paper focuses on what factors deter minor, non-violent crimes, i.e., dishonest actions that violate the law. Much research has been devoted to testing the effectiveness of legal sanctions on crime, while newer models also include social sanctions (judgment of friends or family) and internal sanctions (feelings of guilt). Existing research suggests that both internal sanctions and, to a lesser extent, legal sanctions deter crime, but it is unclear whether this pattern is unique to Western countries or robust across cultures. We administered a survey study to participants in China, Colombia, Germany, Portugal, and USA, five countries from distinct cultural regions of the world. Participants were asked to report the likelihood of engaging in seven dishonest and illegal actions, and were asked to indicate the probability and severity of consequences for legal, friend, family, and internal sanctions. Results indicated that across countries, internal sanctions had the strongest deterrent effects on crime. The deterrent effects of legal sanctions were weaker and varied across countries. Furthermore, the deterrent effects of legal sanctions were strongest when internal sanctions were lax. Unexpectedly, social sanctions were positively related to likelihood of engaging in crime. Taken together, these results suggest that the relative strengths of legal and internal sanctions are robust across cultures and dishonest actions. PMID:26903898

Characterization of oryza sativa acyl activating enzyme3 (OsAAE3)

USDA-ARS?s Scientific Manuscript database

Oxalate, the smallest of the dicarboxylic acids, is produced in many plants. This acid has been shown to play an important role in both plant physiology and defense, specifically in regards to metal detoxification, calcium regulation, sucking and chewing insect deterrence, and the production of calc...

Malpractice Litigation and Nursing Home Quality of Care

PubMed Central

Konetzka, R Tamara; Park, Jeongyoung; Ellis, Robert; Abbo, Elmer

2013-01-01

Objective. To assess the potential deterrent effect of nursing home litigation threat on nursing home quality. Data Sources/Study Setting. We use a panel dataset of litigation claims and Nursing Home Online Survey Certification and Reporting (OSCAR) data from 1995 to 2005 in six states: Florida, Illinois, Wisconsin, New Jersey, Missouri, and Delaware, for a total of 2,245 facilities. Claims data are from Westlaw's Adverse Filings database, a proprietary legal database, on all malpractice, negligence, and personal injury/wrongful death claims filed against nursing facilities. Study Design. A lagged 2-year moving average of the county-level number of malpractice claims is used to represent the threat of litigation. We use facility fixed-effects models to examine the relationship between the threat of litigation and nursing home quality. Principal Findings. We find significant increases in registered nurse-to-total staffing ratios in response to rising malpractice threat, and a reduction in pressure sores among highly staffed facilities. However, the magnitude of the deterrence effect is small. Conclusions. Deterrence in response to the threat of malpractice litigation is unlikely to lead to widespread improvements in nursing home quality. This should be weighed against other benefits and costs of litigation to assess the net benefit of tort reform. PMID:23741985

Effects of excipients and curing process on the abuse deterrent properties of directly compressed tablets.

PubMed

Rahman, Ziyaur; Zidan, Ahmed S; Korang-Yeboah, Maxwell; Yang, Yang; Siddiqui, Akhtar; Shakleya, Diaa; Khan, Mansoor A; Cruz, Celia; Ashraf, Muhammad

2017-01-30

The objective of the present investigation was to understand the effects of excipients and curing process on the abuse deterrent properties (ADP) of Polyox™ based directly compressible abuse deterrent tablet formulations (ADFs). The excipients investigated were lactose (monohydrate or anhydrous), microcrystalline cellulose and hydroxypropyl methylcellulose. The ADPs studied were tablet crush resistance or hardness, particle size distribution following mechanical manipulation, drug extraction in water and alcohol, syringeability and injectability. Other non-ADPs such as surface morphology and tablet dissolution were also studied. It was found that presence of 50% or more of water soluble or swellable excipient in the ADF tablets significantly affected the tablet hardness, particle size distribution following mechanical manipulation and drug extraction while small amount (5%) of excipients had either minimal or no effect on ADPs of these tablets. Addition of high molecular weight HPMC (K 100M) affected syringeability and injectability of ADF. Curing process was found to affect ADPs (hardness, particle size distribution, drug extraction and syringeability and injectability) when compared with uncured tablet. In conclusion, addition of large amount of excipients, especially water soluble ones in Polyox™ based ADF tablets increase the risk of abuse by various routes of administration. Published by Elsevier B.V.

Hardcore drinking drivers and other contributors to the alcohol-impaired driving problem: need for a comprehensive approach.

PubMed

Williams, Allan F; McCartt, Anne T; Ferguson, Susan A

2007-03-01

Understanding the hardcore drinking driver concept in the context of the alcohol-impaired driving problem. Review of the relevant literature. As progress against alcohol-impaired driving slowed in the early 1990s, public and political attention turned to "hardcore" drinking drivers, and they have been a priority for the past 15 years. Though intuitive, the hardcore concept has been difficult to conceptualize. Its definition of hard-to-change chronic heavy drinking drivers focuses on a group that is not easily identifiable and ignores many who account for a large portion of alcohol-impaired driving crashes. These include drivers who drink heavily on occasion and drivers who drink at more moderate levels that elevate crash risk. Emphasis on the hardcore has focused attention on the small proportion of drinking drivers who have been detected and arrested, whereas the vast majority of drinking drivers go undetected. Some countermeasures aimed at the hardcore group have been effective in reducing recidivism, but attention and resources also need to be given to general deterrent initiatives (e.g., 0.08 g/dL, sobriety checkpoints, administrative license suspension). There has been no reduction in the overall alcohol-impaired driving problem since the mid-1990s. Reductions in the alcohol-impaired driving problem require that attention be focused on all relevant target groups. Some benefits could accrue by recognizing that countermeasures developed for hardcore drinking drivers, such as alcohol ignition interlocks and vehicle or plate impoundment, might also be effective with more numerous first-time offenders. However, such strategies are likely to be most effective against recidivism (specific deterrence). Greater gains could be achieved through general deterrent efforts (increasing the real and perceived risk of arrest and punishment to all drinking drivers), along with application of public health measures designed to reduce overall consumption. Additional ways need to be found to separate drinking and driving, either through cultural changes in drinking and/or driving behavior or, in the future, with the use of technology that can make vehicles inoperable by drivers with illegal blood alcohol concentrations.

A Trio of Viral Proteins Tunes Aphid-Plant Interactions in Arabidopsis thaliana

PubMed Central

Du, Zhiyou; Murphy, Alex M.; Anggoro, Damar Tri; Tungadi, Trisna; Luang-In, Vijitra; Lewsey, Mathew G.; Rossiter, John T.; Powell, Glen; Smith, Alison G.; Carr, John P.

2013-01-01

Background Virus-induced deterrence to aphid feeding is believed to promote plant virus transmission by encouraging migration of virus-bearing insects away from infected plants. We investigated the effects of infection by an aphid-transmitted virus, cucumber mosaic virus (CMV), on the interaction of Arabidopsis thaliana, one of the natural hosts for CMV, with Myzus persicae (common names: ‘peach-potato aphid’, ‘green peach aphid’). Methodology/Principal Findings Infection of Arabidopsis (ecotype Col-0) with CMV strain Fny (Fny-CMV) induced biosynthesis of the aphid feeding-deterrent 4-methoxy-indol-3-yl-methylglucosinolate (4MI3M). 4MI3M inhibited phloem ingestion by aphids and consequently discouraged aphid settling. The CMV 2b protein is a suppressor of antiviral RNA silencing, which has previously been implicated in altering plant-aphid interactions. Its presence in infected hosts enhances the accumulation of CMV and the other four viral proteins. Another viral gene product, the 2a protein (an RNA-dependent RNA polymerase), triggers defensive signaling, leading to increased 4MI3M accumulation. The 2b protein can inhibit ARGONAUTE1 (AGO1), a host factor that both positively-regulates 4MI3M biosynthesis and negatively-regulates accumulation of substance(s) toxic to aphids. However, the 1a replicase protein moderated 2b-mediated inhibition of AGO1, ensuring that aphids were deterred from feeding but not poisoned. The LS strain of CMV did not induce feeding deterrence in Arabidopsis ecotype Col-0. Conclusions/Significance Inhibition of AGO1 by the 2b protein could act as a booby trap since this will trigger antibiosis against aphids. However, for Fny-CMV the interplay of three viral proteins (1a, 2a and 2b) appears to balance the need of the virus to inhibit antiviral silencing, while inducing a mild resistance (antixenosis) that is thought to promote transmission. The strain-specific effects of CMV on Arabidopsis-aphid interactions, and differences between the effects of Fny-CMV on this plant and those seen previously in tobacco (inhibition of resistance to aphids) may have important epidemiological consequences. PMID:24349433

Blood donors' perceptions, motivators and deterrents in Sub-Saharan Africa - a scoping review of evidence.

PubMed

Asamoah-Akuoko, Lucy; Hassall, Oliver W; Bates, Imelda; Ullum, Henrik

2017-06-01

Achieving an adequate blood supply in Sub-Saharan Africa (SSA) through donor mobilization and retention is crucial. Factors that motivate or deter blood donors vary according to beliefs and social norms. Understanding the factors that influence blood donation behaviour in SSA is vital to developing effective strategies to address blood donor motivation and retention. This review of 35 studies from 16 SSA countries collates available evidence concerning the perceptions, motivators and deterrents that influence blood donors in SSA. The review revealed a common understanding that blood and blood donation save lives. The main deterrent to blood donation was fear due to lack of knowledge and discouraging spiritual, religious and cultural perceptions of blood donation. The main motivators for blood donation were altruism, donating blood for family and incentives. The findings support the need for targeted, culturally sensitive education, recruitment and retention strategies to improve the blood supply in SSA. © 2017 John Wiley & Sons Ltd.

An evaluation of Nova Scotia's alcohol ignition interlock program.

PubMed

Vanlaar, Ward G M; Mainegra Hing, Marisela; Robertson, Robyn D

2017-03-01

Alcohol ignition interlock programs for offenders aim to reduce recidivism among convicted drink drivers. This study presents an evaluation of Nova Scotia's interlock program implemented in 2008 in order to assess its effectiveness to reduce impaired driving and to help identify areas for improvement. Data used include conviction and crash records of individual participants; provincial monthly counts of alcohol-related charges, convictions and fatal and serious crashes; and interlock logged events. Methods used include descriptive statistics, survival analysis, time series and logistic regression analysis. With respect to specific deterrence (i.e., preventing recidivism) there was a 90% reduction in recidivism among voluntary participants since participation in the interlock program and a 79% reduction after these participants exited from the program. With respect to general deterrence (i.e., referring to a preventative effect on the entire population of drivers in Nova Scotia) there were temporary decreases in the numbers of alcohol-related charges (13.32%) and convictions (9.93%) and a small significant decrease in the number of fatal and serious injury alcohol-related crashes, following the implementation of the program. The evidence suggests the interlock program was better at preventing harm due to alcohol-impaired driving than the alternative of not using the interlock program. Recommendations were formulated supporting the continuation of the interlock program in Nova Scotia. Copyright © 2017 Elsevier Ltd. All rights reserved.

Structural Activity of Bovidic Acid and Related Compounds as Feeding Deterrents against Aedes aegypti

DTIC Science & Technology

2007-01-01

fatty acid analogues were evaluated against Aedes aegypti (L.) mosquitoes and results indicate that this may generate class of topical repellents for use...duced risk to humans, pets and environment, natu- Structural Activity of Bovidic Acid and Related Compounds as Feeding Deterrents against Aedes aegypti K...against insects that transmit pathogens to humans. KEY WORDS : Bovidic acid , feeding deterrents , Aedes aegypti , hydroxy furanoid

Deterrence and WMD Terrorism: Calibrating Its Potential Contributions to Risk Reduction

DTIC Science & Technology

2007-06-01

ideology and aspiration (so-called franchisees ) • operational enablers (financiers etc.) • moral legitimizers • state sponsors • passive state...of al Qaeda • groups affiliated by ideology and aspiration (so-called franchisees ) • operational enablers (financiers etc.) • moral legitimizers...of deterrence.14 One is “deterrence by the threat of punishment,” which compels the adversary to try to calculate whether the potential benefits of

Preference and aversion for deterrent chemicals in two species of Peromyscus mouse.

PubMed

Glendinning, J I

1993-07-01

Deterrent chemicals such as quinine hydrochloride (QHC1) are generally considered to be aversive to mammals at all detectable concentrations. However, several species contain individuals that drink solutions containing low concentrations of deterrents in preference to plain water. The present study examines this paradoxical preference in two species of mouse, Peromyscus melanotis and P. aztecus. Preliminary findings had suggested that whereas some P. aztecus prefer low concentrations of QHC1, no P. melanotis prefer any concentration of QHC1. Experiment 1 tested the hypothesis that individual mice that prefer low concentrations of QHC1 would respond similarly to four other deterrents described by humans as bitter and/or astringent (ouabain, hop extract, sucrose octaacetate, and tannic acid) in 48-h, two-bottle choice tests. Peromyscus aztecus displayed a large amount of intraspecific variation in response to all five deterrents. Those P. aztecus that drank low concentrations of QHC1 in preference to plain water were significantly more likely to respond similarly to low concentrations of the other deterrents. No P. melanotis displayed a preference for any concentration of either deterrent. Experiment 2 examined the temporal stability of the response to 0.1 mM QHC1 in P. aztecus over six consecutive choice tests. Mice were divided into three groups based on their initial response to the QHC1 solution (preference, no response, or rejection) and then subjected to the 12-day test. The response of mice within each of the groups did not change significantly over time.(ABSTRACT TRUNCATED AT 250 WORDS)

Aviation Security, Risk Assessment, and Risk Aversion for Public Decisionmaking

ERIC Educational Resources Information Center

Stewart, Mark G.; Mueller, John

2013-01-01

This paper estimates risk reductions for each layer of security designed to prevent commercial passenger airliners from being commandeered by terrorists, kept under control for some time, and then crashed into specific targets. Probabilistic methods are used to characterize the uncertainty of rates of deterrence, detection, and disruption, as well…

Challenges Involved in the Development and Delivery of Abuse-deterrent Formulations of Opioid Analgesics.

PubMed

Cohen, Joshua P; Mendoza, Mario; Roland, Carl

2018-02-01

This commentary examines the development, regulatory, and reimbursement challenges facing abuse-deterrent formulation (ADF) products. In January 2017, the Tufts Center for the Study of Drug Development convened a roundtable to explore clinical development, regulatory, and reimbursement challenges with respect to ADFs of opioid analgesics. Roundtable participants, who included a range of pharmaceutical industry and other experts, discussed multiple challenges. First, several key clinical development challenges were identified and discussed. These challenges pertain to prodrug development and development of deterrents against oral abuse. Second, experts suggested that more clarity is needed from regulatory authorities regarding standards for proving ADF labeling claims and for being rewarded with 3-year data exclusivity. Similarly, given the substantial burdens associated with the development of postapproval evidence generation, experts raised the need for a consistent regulatory policy related to postapproval evidence generation for all ADFs (branded and generic). Third, despite the public health benefits of certain ADF products, current coverage and access policies impede patient access. Payer justification for restrictive policies appears to be based more on budget impact considerations than cost-effectiveness. Fourth, there remains a need to further expand the evidence base regarding clinical and cost-effectiveness as well as abuse deterrence in a real-world setting for all ADF products. Clinical development challenges need to be overcome with respect to novel ADF technologies, such as prodrugs and deterrents against oral abuse. More clarity is needed from regulatory authorities on labeling claims and data exclusivity eligibility with respect to ADFs. Ensuring prescriber training and awareness of various options for treating pain, including ADF products, is an important step, as is educating payers about the public health benefits of ADFs in appropriate subpopulations of pain patients. In addition, physicians may need to incorporate appropriate risk stratification methods. Finally, it is important to establish a level playing field between coverage of ADF and non-ADF products so that non-ADF products are not given preferred formulary placement. Copyright © 2018 Elsevier HS Journals, Inc. All rights reserved.

Gaming Space: A Game-Theoretic Methodology for Assessing the Deterrent Value of Space Control Options

DTIC Science & Technology

2018-06-07

Gaming Space A Game-Theoretic Methodology for Assessing the Deterrent Value of Space Control Options C O R...in space. Adversaries have already employed non -kinetic OSC capabilities, such as Global Positioning System jammers, in recent conflicts, and they...as part of the project “Assessing the Deterrent Value of Defensive Space Control Options.” The purpose of the project was to develop a methodology

Deterrence with China: Avoiding Nuclear Miscalculation

DTIC Science & Technology

2014-01-01

When each nation can manage these three elements in the correct way, the cost -benefit calculations of each side should favor deterrence of a...under pressure to justify the cost of its plans to replace its SSBN fleet. After a recent 2-year delay in the planned SSBN replacement program, any...of CPGS may prove advantageous in some scenarios,31 but those advantages do not come with- out a cost to nuclear deterrence stability with China—a

On Nuclear Deterrence and Assurance

DTIC Science & Technology

2009-01-01

Strategic  Studies  Quarterly ♦  Spring  2009 [ 43 ] On Nuclear Deterrence  and Assurance Keith B. Payne Weakness is provocative. —Donald Rumsfeld...Strategic  Studies  Quarterly ♦  Spring  2009 Keith B. Payne [ 44 ] No Deterrence Value for Nuclear Weapons...Payne.indd 44 2/2/09 2:31:00 PM On Nuclear Deterrence and Assurance Strategic  Studies  Quarterly ♦  Spring  2009 [ 45 ] of nuclear weapons were to be

Malnutrition: A Deterrent to Human Progress

ERIC Educational Resources Information Center

Johnson, Nancy E.; Found, R. Elaine

1971-01-01

Authors discuss the effects of malnutrition on retardation of mental development and intellectual capacity. Research findings on undernourished experimental animals are cited as well as studies involving children suffering the effects of malnutrition in infancy. (Editor/LF)

Paddling, Punishing and Force

ERIC Educational Resources Information Center

Hyman, Irwin A.; And Others

1977-01-01

Discusses the extent and use of corporal punishment in public schools, the results of research on the effectiveness of corporal punishment as a deterrent to misbehavior, and the use and effect of alternative measures of classroom management. (BF)

Assessing the Deterrence Value of Carrier Presence Against Adversary Aggression in a Coalition Environment

DTIC Science & Technology

2017-09-01

seeks to quantify the deterrence value of a CSG using a game - theoretic framework. Consider a region with several nations, where two major players stand...develop a Markov game to model the interactions between the two players and these other nations over a period of time. The game starts in Notional...establishing diplomatic advantage are equally important in deterring aggression. 14. SUBJECT TERMS carrier strike group, CSG, deterrence, Markov game

A Study on the Failure of Conventional Deterrence: The Case Study of the Bombardment of Yeonpyeong in 2010

DTIC Science & Technology

2016-12-01

December 2016 3. REPORT TYPE AND DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE A STUDY ON THE FAILURE OF CONVENTIONAL DETERRENCE: THE CASE ...Approved for public release. Distribution is unlimited A STUDY ON THE FAILURE OF CONVENTIONAL DETERRENCE: THE CASE STUDY OF THE BOMBARDMENT OF...necessary to analyze these diverse elements comprehensively. E. RESEARCH DESIGN This thesis focuses on a single case study about the bombardment of

Strategic Studies Quarterly. Volume 6, Number 2. Summer 2012

DTIC Science & Technology

2012-06-01

Jr . Forging an Indian Partnership Capt Craig H. Neuman II, USAF Chasing Its Tail: Nuclear Deterrence in the Information Age? Stephen J. Cimbala Commentary Our Brick Moon William H. Gerstenmaier ...Su m m er 2012 SUMMER 2012 Vol. 6, No. 2 Commentary Our Brick Moon William H. Gerstenmaier Chasing Its Tail: Nuclear Deterrence in...Extended Deterrence: How Much Strategic Force Is Too Little? David J. Trachtenberg The Common Sense of Small Nuclear Arsenals James Wood Forsyth

Feeding deterrent compounds to the boll weevil,Anthonomus grandis Boheman in Rose-of-Sharon,Hibiscus syriacus L.

PubMed

Bird, T G; Hedin, P A; Burks, M L

1987-05-01

The Rose-of-Sharon,Hibiscus syriacus (L.), can be a significant alternate host plant for the boll weevil,Anthonomus gradis (Boh.). Boll weevils are known to be deterred from feeding and ovipositing in the buds unless the calyx is removed. This investigation was initiated to identify calyx allelochemicals that deter feeding with the eventual strategy of breeding for cotton lines high in these allelochemicals in the appropriate tissues. The feeding deterrency of calyx tissue from the buds of Rose-of-Sharon for the boll weevil was confirmed. The most active deterrent fraction was found to contain mostly fatty acids and their methyl esters. Saturated fatty acids and their methyl esters were generally found to be stimulatory, while the unsaturated species were found to be deterrent. Higher quantities of the fatty acids, particularly the unsaturated species, were found in Rose-of-Sharon calyx tissue than in the buds without calyx. This supports the hypothesis developed through the isolational work and testing of standards that the unsaturated fatty acids are significant deterrents of boll weevil feeding.

Isolation and Identification of Mosquito (Aedes aegypti) Biting-Deterrent Compounds from the Native American Ethnobotanical Remedy Plant Hierochloë odorata (Sweetgrass).

PubMed

Cantrell, Charles L; Jones, A Maxwell P; Ali, Abbas

2016-11-09

Hierochloë odorata (L.) P. Beauv. (Poaceae), commonly known as sweetgrass, has documented use as an insect repellent by the Flatheads of Montana and Blackfoot of Alberta. Both the Flatheads of Montana and Blackfoot of Alberta would use braided plant material in a sachet in clothing or burn them from one end as incense, air/clothing freshener, and insect repellent. This study evaluated the insect-repellent properties of this plant using an in vitro mosquito Aedes aegypti feeding bioassay-directed approach to identify the compound(s) responsible for the observed activities. Evaluation of crude extracts produced from H. odorata revealed that the hydrodistillate had the highest level of mosquito biting deterrence. Fractionation of this extract, followed by re-evaluation for mosquito biting deterrence, produced many active fractions, which were evaluated by spectroscopic techniques and determined to contain phytol, coumarin, and 2-methoxy-4-vinylphenol. Phytol and coumarin were both determined to be responsible for the Ae. aegypti biting deterrency. Scientific evidence reported here validates its traditional use as a biting-insect deterrent.

Cyber Deterrence and Stability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goychayev, Rustam; Carr, Geoffrey A.; Weise, Rachel A.

Throughout the 20th and early 21st centuries, deterrence and arms control have been cornerstones of strategic stability between the superpowers. However, the weaponization of the cyber realm by State actors and the multipolar nature of cyber conflict now undermines that stability. Strategic stability is the state in which nations believe that if they act aggressively to undermine U.S. national interests and the post-World War II liberal democratic order, the consequences will outweigh the benefits. The sense of lawlessness and lack of consequences in the cyber realm embolden States to be more aggressive in taking actions that undermine stability. Accordingly, thismore » paper examines 1) the role of deterrence and arms control in securing cyber stability, and 2) the limitations and challenges associated with these traditional national security paradigms as applied to this emerging threat domain. This paper demonstrates that many 20th-century deterrence and arms control concepts are not particularly applicable in the cyber realm. However, they are not entirely irrelevant. The United States can distill lessons learned from this rich deterrence and arms control experience to develop and deploy a strategy to advance cyber stability.« less

Random breath testing in Australia: getting it to work according to specifications.

PubMed

Homel, R

1993-01-01

After reading the deterrence literature, particularly the work of H. Laurence Ross, I concluded in the late 1970's that many road accidents could be prevented through the wholehearted implementation of random breath testing (RBT). RBT is a system of drink-drive law enforcement which aims to increase the perceived likelihood of apprehension through the use of mass breath testing techniques at roadblocks which are highly visible, are unpredictable in their locations and give the impression of ubiquity. As the result of public pressure, RBT was introduced in NSW in December 1982, with spectacular results. The law was intensively enforced and extensively advertised, partly due to the advocacy of researchers such as myself, but also because ther was an acute political need for instant results. Since RBT is a difficult enforcement technique for police to sustain in effective form, researchers must strive to improve their understanding of what works, and remain in close contact with police, policy makers and politicians. Although this process is costly in terms of time and, possibly, academic 'pay-off', it is essential if the fragile understanding of deterrence principles amongst these groups is not to lead to superficially attractive, but probably ineffective techniques such as low visibility mobile RBT.

Simulated seal scarer sounds scare porpoises, but not seals: species-specific responses to 12 kHz deterrence sounds

PubMed Central

Hermannsen, Line; Beedholm, Kristian

2017-01-01

Acoustic harassment devices (AHD) or ‘seal scarers’ are used extensively, not only to deter seals from fisheries, but also as mitigation tools to deter marine mammals from potentially harmful sound sources, such as offshore pile driving. To test the effectiveness of AHDs, we conducted two studies with similar experimental set-ups on two key species: harbour porpoises and harbour seals. We exposed animals to 500 ms tone bursts at 12 kHz simulating that of an AHD (Lofitech), but with reduced output levels (source peak-to-peak level of 165 dB re 1 µPa). Animals were localized with a theodolite before, during and after sound exposures. In total, 12 sound exposures were conducted to porpoises and 13 exposures to seals. Porpoises were found to exhibit avoidance reactions out to ranges of 525 m from the sound source. Contrary to this, seal observations increased during sound exposure within 100 m of the loudspeaker. We thereby demonstrate that porpoises and seals respond very differently to AHD sounds. This has important implications for application of AHDs in multi-species habitats, as sound levels required to deter less sensitive species (seals) can lead to excessive and unwanted large deterrence ranges on more sensitive species (porpoises). PMID:28791155

Effects of Ginkgo biloba constituents on fruit-infesting behavior of codling moth (Cydia pomonella) in apples.

PubMed

Pszczolkowski, Maciej A; Durden, Kevin; Sellars, Samantha; Cowell, Brian; Brown, John J

2011-10-26

Codling moth, Cydia pomonella (L.), is a cosmopolitan pest of apple, potentially causing severe damage to the fruit. Currently used methods of combating this insect do not warrant full success or are harmful to the environment. The use of plant-derived semiochemicals for manipulation with fruit-infesting behavior is one of the new avenues for controlling this pest. Here, we explore the potential of Ginkgo biloba and its synthetic metabolites for preventing apple feeding and infestation by neonate larvae of C. pomonella. Experiments with crude extracts indicated that deterrent constituents of ginkgo are present among alkylphenols, terpene trilactones, and flavonol glycosides. Further experiments with ginkgo synthetic metabolites of medical importance, ginkgolic acids, kaempferol, quercetin, isorhamnetin, ginkgolides, and bilobalide, indicated that three out of these chemicals have feeding deterrent properties. Ginkgolic acid 15:0 prevented fruit infestation at concentrations as low as 1 mg/mL, bilobalide had deterrent effects at 0.1 mg/mL and higher concentrations, and ginkgolide B at 10 mg/mL. On the other hand, kaempferol and quercetin promoted fruit infestation by codling moth neonates. Ginkgolic acids 13:0, 15:1, and 17:1, isorhamnetin, and ginkgolides A and C had no effects on fruit infestation-related behavior. Our research is the first report showing that ginkgo constituents influence fruit infestation behavior and have potential applications in fruit protection.

Domestic Violence Courts: A Multisite Test of Whether and How They Change Offender Outcomes.

PubMed

Cissner, Amanda B; Labriola, Melissa; Rempel, Michael

2015-09-01

Findings are from an investigation of 24 criminal domestic violence courts (DVCs) across New York, testing their effect on recidivism, case processing, and case resolutions. Overall, we found a small positive impact on recidivism among convicted offenders. We further found that the sex of defendants moderated the court impact on case resolutions; that is, among male defendants only, DVCs increased conviction rates and sentences involving jail or prison. In addition, multi-level, multivariate analyses found that court policies specifically designed to increase victim safety, hold offenders accountable, and reduce offender recidivism (through deterrence or rehabilitation) were instrumental in reducing recidivism. © The Author(s) 2015.

Deterrence vs. Assurance: The U.S. Naval Presence in the Persian Gulf

DTIC Science & Technology

more significant contribution to regional stability in the greater Middle East region. This research draws from two cases: the Navys deterrence-based...indicate that Iran poses little threat to the Strait of Hormuz for various economic and military reasons, suggesting that perhaps the Navys policy of...positive impact on regional stability . If the Navy seeks to use its warships as a stabilizing force in the region, it should restructure its strategy and employ ships in ways that provide assurance, not deterrence.

Validation of Rational Deterrence Theory: Analysis of U.S. Government and Adversary Risk Propensity and Relative Emphasis on Gain or Loss

DTIC Science & Technology

2010-03-01

policy (Achen & Snidal, 1989). Huth and Russett (1984) emphasize : “if we do not know how deterrence works when it is most needed, policies assigned...application of deterrence to U.S. adversaries in these policies. Analysis of risk propensity and relative emphases on loss/gain of those actors...research, the strategic environment. Evidence of such assessment may reflect an adversary’s risk propensities and relative emphases on loss/gain; however

Family Relationships and Parental Monitoring during Middle School as Predictors of Early Adolescent Problem Behavior

ERIC Educational Resources Information Center

Fosco, Gregory M.; Stormshak, Elizabeth A.; Dishion, Thomas J.; Winter, Charlotte E.

2012-01-01

The middle school years are a period of increased risk for youths' engagement in antisocial behaviors, substance use, and affiliation with deviant peers (Dishion & Patterson, 2006). This study examined the specific role of parental monitoring and of family relationships (mother, father, and sibling) that are all critical to the deterrence of…

Acoustical deterrence of Silver Carp (Hypophthalmichthys molitrix)

USGS Publications Warehouse

Brooke J. Vetter,; Cupp, Aaron R.; Fredricks, Kim T.; Gaikowski, Mark P.; Allen F. Mensinger,

2015-01-01

The invasive Silver Carp (Hypophthalmichthys molitrix) dominate large regions of the Mississippi River drainage and continue to expand their range northward threatening the Laurentian Great Lakes. This study found that complex broadband sound (0–10 kHz) is effective in altering the behavior of Silver Carp with implications for deterrent barriers or potential control measures (e.g., herding fish into nets). The phonotaxic response of Silver Carp was investigated using controlled experiments in outdoor concrete ponds (10 × 4.9 × 1.2 m). Pure tones (500–2000 Hz) and complex sound (underwater field recordings of outboard motors) were broadcast using underwater speakers. Silver Carp always reacted to the complex sounds by exhibiting negative phonotaxis to the sound source and by alternating speaker location, Silver Carp could be directed consistently, up to 37 consecutive times, to opposite ends of the large outdoor pond. However, fish habituated quickly to pure tones, reacting to only approximately 5 % of these presentations and never showed more than two consecutive responses. Previous studies have demonstrated the success of sound barriers in preventing Silver Carp movement using pure tones and this research suggests that a complex sound stimulus would be an even more effective deterrent.

Reexamining the frequency range of hearing in silver (Hypophthalmichthys molitrix) and bighead (H. nobilis) carp

USGS Publications Warehouse

Vetter, Brooke J.; Brey, Marybeth; Meninger, Allen F.

2018-01-01

Silver (Hypophthalmichthys molitrix) and bighead (H. nobilis) carp (collectively bigheaded carp) are invasive fish that threaten aquatic ecosystems in the upper Midwest United States and the Laurentian Great Lakes. Controlling bigheaded carp is a priority of fisheries managers and one area of focus involves developing acoustic deterrents to prevent upstream migration. For an acoustic deterrent to be effective however, the hearing ability of bigheaded carp must be characterized. A previous study showed that bigheaded carp detected sound up to 3 kHz but this range is narrower than what has been reported for other ostariophysans. Therefore, silver and bighead carp frequency detection was evaluated in response to 100 Hz to 9 kHz using auditory evoked potentials (AEPs). AEPs were recorded from 100 Hz to 5 kHz. The lowest thresholds were at 500 Hz for both species (silver carp threshold: 80.6 ± 3.29 dB re 1 μPa SPLrms, bighead carp threshold: 90.5 ± 5.75 dB re 1 μPa SPLrms; mean ± SD). These results provide fisheries managers with better insight on effective acoustic stimuli for deterrent systems, however, to fully determine bigheaded carp hearing abilities, these results need to be compared with behavioral assessments.

Variability in chemical defense across a shallow to mesophotic depth gradient in the Caribbean sponge Plakortis angulospiculatus

NASA Astrophysics Data System (ADS)

Slattery, Marc; Gochfeld, Deborah J.; Diaz, M. Cristina; Thacker, Robert W.; Lesser, Michael P.

2016-03-01

The transition between shallow and mesophotic coral reef communities in the tropics is characterized by a significant gradient in abiotic and biotic conditions that could result in potential trade-offs in energy allocation. The mesophotic reefs in the Bahamas and the Cayman Islands have a rich sponge fauna with significantly greater percent cover of sponges than in their respective shallow reef communities, but relatively low numbers of spongivores. Plakortis angulospiculatus, a common sponge species that spans the depth gradient from shallow to mesophotic reefs in the Caribbean, regenerates faster following predation and invests more energy in protein synthesis at mesophotic depths compared to shallow reef conspecifics. However, since P. angulospiculatus from mesophotic reefs typically contain lower concentrations of chemical feeding deterrents, they are not able to defend new tissue from predation as efficiently as conspecifics from shallow reefs. Nonetheless, following exposure to predators on shallow reefs, transplanted P. angulospiculatus from mesophotic depths developed chemical deterrence to predatory fishes. A survey of bioactive extracts indicated that a specific defensive metabolite, plakortide F, varied in concentration with depth, producing altered deterrence between shallow and mesophotic reef P. angulospiculatus. Different selective pressures in shallow and mesophotic habitats have resulted in phenotypic plasticity within this sponge species that is manifested in variable chemical defense and tissue regeneration at wound sites.

The effects of picric acid (2,4,6-trinitrophenol) and a bite-deterrent chemical (denatonium benzoate) on autotomy in rats after peripheral nerve lesion.

PubMed

Firouzi, Matin Sadat; Firouzi, Masoumeh; Nabian, Mohammad Hossein; Zanjani, Leila Oryadi; Zadegan, Shayan Abdollah; Kamrani, Reza Shahryar; Rahimi-Movaghar, Vafa

2015-04-01

Denervation of the hind limb is a technique used to study peripheral nerve regeneration. Autotomy or autophagia is an undesirable response to denervation in such studies. Application of a commercially available lotion used to deter nail biting in humans reduced autotomy in rats after denervation but did not completely prevent it. In this study, this authors evaluated the application of picric acid to prevent autotomy in rats in peripheral nerve experiments. They carried out sciatic nerve transection in 41 adult female Wistar rats and then applied either bite-deterrent lotion (n = 26) or saturated picric acid solution (n = 15) topically to the affected hind limb immediately after surgery and every day for 1 month. Autotomy scores were lower for rats treated with picric acid than for rats treated with bite-deterrent lotion 1 week and 2 weeks after surgery but were not different between the two groups 4 weeks after surgery. The authors conclude that application of picric acid could be used as an alternative strategy to prevent autotomy in peripheral nerve studies.

Remixing the ‘Appropriate Mix’: Reassessing NATO’s Deterrence and Defense Posture in the Face of New Threats

DOE Office of Scientific and Technical Information (OSTI.GOV)

Juarez, Anthony

The North Atlantic Treaty Organization (NATO) and the countries of Europe face a renewed challenge from the east vis-à-vis the Putin regime in Moscow. In the face of these new challenges, NATO must reconsider its deterrence and defense posture in order to deter conflict in Europe. Unfortunately, Russian attempts to rewrite the rules of the post-Cold War international order by force have been coupled with nuclear saber rattling and overt nuclear threats. Russia’s nuclear threats, in addition to provocative changes to Russia’s nuclear posture in its Military Doctrine, are methods to make up for Russia’s conventional military inferiority relative tomore » NATO and the United States. Some have described Moscow’s actions as laying the groundwork for a nuclear coercion strategy. While the decrease in the nuclear arsenals of Russia and the United States has reduced the likelihood of nuclear annihilation to an all-time low since the height of the Cold War, Russia’s nuclear coercion strategy is increasing the probability of nuclear employment in Europe. The probability of nuclear use is compounded by Russia’s tremendous local military advantage around its periphery in spite of U.S. global military primacy. This military advantage increases the incentive to use military force if Russian decision-makers conclude that a quick military victory is possible, or if Russian leaders miscalculate based on an incorrect assessment of military force balance or resolve of their adversary. The integration of Lithuania, Latvia, and Estonia (referred to as the Baltics in this paper) into the NATO alliance in 2004 makes Russia’s military advantage in its periphery increasingly relevant. Each NATO state is required to assist any NATO state that comes under attack per Article V of the North Atlantic Treaty. The Baltic states’ proximity to Russia, their weak indigenous militaries, their former status as Soviet Republics, large population of ethnic Russians, and Russian President Vladimir V. Putin’s claim that he will protect Russians wherever they are makes the Baltics the most likely flashpoint for conflict between NATO and Russia. This analysis will tackle the problem of reshaping NATO’s deterrence and defense posture in light of the new Russian threat and its obligation to defend its most vulnerable members. Specifically, it will assess the suitability of NATO’s “appropriate mix” of nuclear, conventional, and missile defense capabilities to deterring conventional conflict with Russia and, if conventional deterrence fails, preventing Russian nuclear escalation. It will use a scenario-based approach informed by a deterrence model to explore how changes to NATO’s posture and policy could impact the deterrence of Russian aggression.« less

U.S. Regional Deterrence Strategies

DTIC Science & Technology

1995-01-01

MOTIVATIONS OF REGIONAL ADVERSARIES ............................. 27 Regime Types ................................. 27 Domestic Political Instability...32 Historical Cases Illustrating the influence of Domestic Politics .................................. 36 China, 1950... Political Constraints ............................. 86 Military Constraints ............. II................89 Deterrence in U.S. Regional Strategy

Repellent and deterrent effects of SS220, Picaridin, and Deet suppress human blood feeding by Aedes aegypti, Anopheles stephensi, and Phlebotomus papatasi.

PubMed

Klun, Jerome A; Khrimian, Ashot; Debboun, Mustapha

2006-01-01

A series of behavioral tests with Aedes aegypti (L.), Anopheles stephensi Liston, mosquitoes, and the sand fly Phlebotomus papatasi Scopoli in the presence of Deet, SS220, and Picaridin topically applied to the skin of human volunteers showed that the insects were deterred from feeding on and repelled from surfaces emanating the compounds. When offered a 12- or 24-cm2 area of skin, one-half treated with compound and one-half untreated, the insects fed almost exclusively on untreated skin. The sand flies and mosquitoes did not at any time physically contact chemically treated surfaces. When treated and untreated skin areas were covered with cloth, insects contacted, landed, and bit only through cloth covering untreated skin. These observations provided evidence that the compounds deterred feeding and repelled insects from treated surfaces primarily as a result of olfactory sensing. When cloth, one-half untreated and one-half treated with chemical, was placed over untreated skin, insects only touched and specifically bit through the untreated cloth. This showed that the activity of the chemicals does not involve a chemical x skin interaction. In the presence of any of the three chemicals, no matter how they were presented to the insects, overall population biting activity was reduced by about one-half relative to controls. This reduction showed a true repellent effect for the compounds. Results clearly showed that Deet, SS220, and Picaridin exert repellent and deterrent effects upon the behavior of mosquitoes and sand flies. Heretofore, the combined behavioral effects of these compounds upon mosquito and sand fly behavior were unknown. Moreover, protection afforded by Deet, SS220, and Picaridin against the feeding of these three disease vectors on humans is mechanistically a consequence of the two chemical effects.

Effect of Surround WP on behavior and mortality of apple maggot (Diptera: Tephritidae).

PubMed

Leskey, Tracy C; Wright, Starker E; Glenn, D Michael; Puterka, Gary J

2010-04-01

Apple maggot, Rhagoletis pomonella (Walsh) (Diptera: Tephritidae), is a key pest in apple (Malus spp.) production areas located in the northeastern and midwestern United States and the eastern provinces of Canada. The development of Surround WP has offered a new approach for controlling apple maggot and other tephritid species, because this material is considered to be compatible with advanced integrated pest management and organic production systems. We conducted studies aimed at identifying the behavioral and biological effects of this material on apple maggots. Specifically, we examined the effect of Surround WP on the visual ecology of adult flies under field conditions, on tactile responses of flies in semifield trials, and on fly mortality in laboratory-based-bioassays. We demonstrated that an even coating of white particles over a fruit-mimicking sphere surface reduced visual attractiveness. We also found that spotty-coated fruit-mimicking spheres (meant to mimic ripe fruit bearing an uneven coating of Surround WP) were perceived by flies as not having the ideal round silhouette shape stimulus. Surround WP served as a tactile deterrent; the residence time of females introduced on to treated fruit was much shorter compared with untreated fruit. Surround WP also had a toxic effect on both adult apple maggot and Rhagoletis suavis (Loew); flies exposed to and forced to stand on Surround-treated surfaces died in <2 d in all trials. The combined effectiveness of Surround WP is based on a reduction in the attractiveness of fruit-based visual cues, an increase in the likelihood of flies leaving treated surfaces due to tactile deterrence, and a potential for increased mortality due to exposure to Surround WP particles.

Deterrence before Hiroshima

DOE Office of Scientific and Technical Information (OSTI.GOV)

Quester, G.H.

The gap between studies of military history and military strategy is ever widening. The enormous destructive power of nuclear weapons has tended to persuade us that the military experience of the first half of this century is not relevant to more ''modern'' military questions. In Deterrence before Hiroshima, first published in 1966, George H. Quester analyzes pre-nuclear age theories of deterrence to equip us with a perspective and data by which current theories can be evaluated. Quester shows that from almost the time of the first military aircraft, air-power was believed to have the capacity for apocalyptic destruction. He pointsmore » out that the modern terms deterrence, limited war, tacit agreement, and balance of terror, show up often in the literature from 1900-1945, coupled with war scenarios every bit as awesome as a nuclear holocaust.« less

Age, gender and deterrability: Are younger male drivers more likely to discount the future?

PubMed

Freeman, James; Kaye, Sherrie-Anne; Truelove, Verity; Davey, Jeremy

2017-07-01

Utilizing the Classical Deterrence theory and Stafford and Warr's (1993) reconceptualized model of deterrence, the current study examined whether age, gender, and discounting the future tendencies influence perceptions of being apprehended for speeding offences. Licensed motorists (N=700; 57% female) in Queensland (Australia) were recruited to complete a self-report questionnaire that measured perceptual deterrence, speeding related behaviors and discounting the future tendencies. Data were analyzed utilizing descriptive, bivariate and multivariate regressions. Significant (albeit weak) positive correlations were found between age and perceptions of apprehension certainty. Males were significantly more likely to report higher incidences of speeding (including while avoiding detection) compared to females. In contrast, females were more likely to perceive high levels of apprehension certainty and consider impending penalties to be more severe. At a multivariate level, discounting the future tendencies (in addition to being male, reporting lower levels of perceptual severity and swiftness, and more instances of punishment avoidance) were predictive of lower perceptual certainty levels. This study is one of the first to reveal that being male and having a tendency to discount the consequences of the future may directly influence drivers' perceptual deterrence levels. Copyright © 2017 Elsevier Ltd. All rights reserved.

The effectiveness of laser and radar based enforcement programs for deterrence of speeding

DOT National Transportation Integrated Search

1997-02-01

This report documents the results of a study to determine the community-wide effectiveness of laser-based speed enforcement programs relative to radar-based programs. Jurisdiction-wide speeding enforcement programs were implemented and evaluated in t...

Summary Report - Strategic Weapons on the 21st Century Conference

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roberts, B.

2017-04-21

This 11th annual event focused on changes in the security environment and their implications for the U.S. approach to deterrence, with special attention to extended deterrence in Europe and East Asia.

Deterrents to Change.

ERIC Educational Resources Information Center

Dyer, John

1984-01-01

Identifies some of the current forces influencing global change; speculates on possible ramifications of these forces for changes in a school system; and suggests what possible deterrents and inhibitors operating in large public education systems are preventing change. (SB)

School discipline and disruptive classroom behavior: the moderating effects of student perceptions.

PubMed

Way, Sandra M

2011-01-01

This study examines the relationship between school discipline and student classroom behavior. A traditional deterrence framework predicts that more severe discipline will reduce misbehavior. In contrast, normative perspectives suggest that compliance depends upon commitment to rules and authority, including perceptions of fairness and legitimacy. Using school and individual-level data from the National Education Longitudinal Study of 1988 and multilevel regression modeling, the author finds support for the normative perspective. Students who perceive school authority as legitimate and teacher–student relations as positive are rated as less disruptive. While perceptions of fairness also predict lower disruptions, the effects are mediated by positive teacher–student relations. Contrary to the deterrence framework, more school rules and higher perceived strictness predicts more, not less, disruptive behavior. In addition, a significant interaction effect suggests that attending schools with more severe punishments may have the unintended consequence of generating defiance among certain youth.

Recurrent issues in efforts to prevent homicidal youth violence in schools: expert opinions.

PubMed

Dill, Karen E; Redding, Richard E; Smith, Peter K; Surette, Ray; Cornell, Dewey G

2011-01-01

Developmental research on social influences on adolescents can guide practices aimed to prevent homicidal youth violence. School shootings have repeatedly raised questions about the contributory role of bullying and entertainment violence, how news media publicity might produce copycat crimes, and whether stiffer criminal sanctions might have a deterrent effect. This article presents the thoughts and recommendations of a group of experts on these topics summarizing the current knowledge base. In brief, bullying reduction programs may be a useful early prevention effort. Television and video games with violent themes can encourage aggressive behavior, but these media can be used to teach more prosocial behavior as well. The potential copycat effects of highly publicized crimes might be diminished with more restrained reporting, although more research is needed. Finally, there is substantial evidence that increased criminal sanctions for youthful offenders have not had a deterrent effect. Copyright © 2011 Wiley Periodicals, Inc., A Wiley Company.

Strategic, Tactical and Doctrinal Military Concepts. The Deterrence Concept: A Synthesis Based on a Survey of the Literature.

DTIC Science & Technology

1980-04-01

influence appears strongest, that the work is most ab - stract, and that the results have seemed to cause the most prob- lems when applied to the real...deterrence to the world at large, for Churchill’s clear exposi - tion of the basic concept, and as probably the first major statement on deterrence...works cited are in general ab - stract and theoretical, or minor and irrelevant. Also, since most of the bibliography cited is from the 1950’s (a single

What deters nurses from participating in web-based graduate nursing programs?: A cross-sectional survey research study.

PubMed

Carpenter, Suzanne H

2016-01-01

A graduate degree is required of nursing faculty in America. Because of the nursing faculty shortage, web-based graduate nursing programs are being offered to encourage nurses to return to school. The identification of deterrents to participating in these programs is an important step in increasing enrollment. To identify deterrents to participation in web-based graduate nursing programs. Descriptive survey research. Louisiana Two hundred and eighty-one registered nurse members of the Louisiana Nurses' Association. The 54-item four-point Likert-type interval scale Deterrents to Participation in Web-Based Graduate Nursing Programs Survey Instrument was used. Data were collected over 8weeks using SurveyMonkey.com to administer the web survey tool to all members of the Louisiana State Nurses' Association. A factor analysis revealed a three-factor solution that explained 55.436% of the total variance in deterrents to participation in web-based graduate nursing programs. The factors were labeled "concerns about quality, cost, and time," "concerns about access to resources: technological and personal," and "concerns about electronic mediated communication." Multiple regression analysis revealed an overall model of three predictors of deterrents to participation in web-based graduate nursing programs: no computer literacy, annual household income between 20,000 and 50,000 dollars, and having the current educational status of graduating from a diploma RN program. This model accounted for 21% of the variance in the deterrents to participation scores. Since these three significant predictors of deterrents to participation in web-based graduate nursing programs were identified, web-based nursing graduate program administrators might consider an outreach to RN diploma graduates in an effort to make them aware of available technology support programs to foster participation. Scholarships for lower income nursing students are recommended, and programs to support computer literacy within the nursing community should be considered. Copyright © 2015 Elsevier Ltd. All rights reserved.

Transitions to Engagement among Low-Income Cohabiting African American Couples: A Family Perspective for Policy

ERIC Educational Resources Information Center

Chaney, Cassandra; Monroe, Pamela

2011-01-01

With passage of the Welfare Reform Law of 1996, various national, state, and local programs were created to encourage marriage, particularly among low-income African American cohabiting couples with children. However, policy makers know little about the deterrents to marriage for members of this group. More specifically, there is a lack of data…

"Nuclear Deterrence" as an Adaptive Game Frame for Crisis Decision-Making.

ERIC Educational Resources Information Center

Sorenson, David S.

1981-01-01

Describes the simulation game "Nuclear Deterrence," which was developed to model an international relations crisis situation involving a bargaining framework potentially applicable to crisis modeling in other disciplines. Eight references are listed. (Author/LLS)

Deterrent activity of hops flavonoids and their derivatives against stored product pests.

PubMed

Jackowski, J; Popłoński, J; Twardowska, K; Magiera-Dulewicz, J; Hurej, M; Huszcza, E

2017-10-01

Five flavonoids from hops, two of their derivatives, along with naringenin used as a model compound, were tested for their antifeedant activity against three coleopteran stored product pests: Sitophilus granarius L., Tribolium confusum Duv. and Trogoderma granarium Everts. The introduction, into the tested flavonoid molecules, of additional structural fragments such as prenyl or dimethylpyran moiety, is proposed to significantly alter the deterrent activity of the compounds. The prenyl moiety in flavonoids increased the deterrent activity of these compounds in all three of the grain feeding species used in the tests. It is also concluded that the introduction of dimethylpyran moiety to the flavonoid structure increases its deterrent activity in S. granarius and T. confusum, but in one of the test insects, T. granarium, an increased feeding was observed in response to the introduction of dimethylpyran moiety to the flavonoid structure.

32 CFR 16.3 - Available sentences.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Forces of the United States and of the broad deterrent impact associated with a sentence's effect on... recommendation to suspend, remit, commute or otherwise modify the adjudged sentence in concert with one or more...

Structure-activity relationship studies on the mosquito toxicity and biting deterrency of callicarpenal derivatives.

PubMed

Cantrell, Charles L; Klun, Jerome A; Pridgeon, Julia; Becnel, James; Green, Solomon; Fronczek, Frank R

2009-04-01

Callicarpenal (=13,14,15,16-tetranorclerod-3-en-12-al=[(1S,2R,4aR,8aR)-1,2,3,4,4a,7,8,8a-octahydro-1,2,4a,5-tetramethylnaphthalen-1-yl]acetaldehyde; 1) has previously demonstrated significant mosquito bite-deterring activity against Aedes aegypti and Anopheles stephensi in addition to repellent activity against host-seeking nymphs of the blacklegged tick, Ixodes scapularis. In the present study, structural modifications were performed on callicarpenal (1) in an effort to understand the functional groups necessary for maintaining and/or increasing its activity and to possibly lead to more effective insect control agents. All modifications in this study targeted the C(12) aldehyde or the C(3) alkene functionalities or combinations thereof. Mosquito biting deterrency appeared to be influenced most by C(3) alkene modification as evidenced by catalytic hydrogenation that resulted in a compound having significantly less effectiveness than 1 at a test amount of 25 nmol/cm2. Oxidation and/or reduction of the C(12) aldehyde did not diminish mosquito biting deterrency, but, at the same time, none of the modifications were more effective than 1 in deterring mosquito biting. Toxicities of synthesized compounds towards Ae. aegypti ranged from an LD50 value of 2.36 to 40.11 microg per mosquito. Similarly, LD95 values ranged from a low of 5.59 to a high of 104.9 microg.

Evaluation of the Activity of the Essential Oil from an Ornamental Flower against Aedes aegypti: Electrophysiology, Molecular Dynamics and Behavioral Assays.

PubMed

Bezerra-Silva, Patrícia C; Dutra, Kamilla A; Santos, Geanne K N; Silva, Rayane C S; Iulek, Jorge; Milet-Pinheiro, Paulo; Navarro, Daniela M A F

2016-01-01

Dengue fever has spread worldwide and affects millions of people every year in tropical and subtropical regions of Africa, Asia, Europe and America. Since there is no effective vaccine against the dengue virus, prevention of disease transmission depends entirely on regulating the vector (Aedes aegypti) or interrupting human-vector contact. The aim of this study was to assess the oviposition deterrent activity of essential oils of three cultivars of torch ginger (Etlingera elatior, Zingiberaceae) against the dengue mosquito. Analysis of the oils by gas chromatography (GC)-mass spectrometry revealed the presence of 43 constituents, of which α-pinene, dodecanal and n-dodecanol were the major components in all cultivars. Solutions containing 100 ppm of the oils exhibited oviposition deterrent activities against gravid Ae. aegypti females. GC analysis with electroantennographic detection indicated that the oil constituents n-decanol, 2-undecanone, undecanal, dodecanal, trans-caryophyllene, (E)-β-farnesene, α-humulene, n-dodecanol, isodaucene and dodecanoic acid were able to trigger antennal depolarization in Ae. aegypti females. Bioassays confirmed that solutions containing 50 ppm of n-dodecanol or dodecanal exhibited oviposition deterrent activities, while a solution containing the alcohol and aldehyde in admixture at concentrations representative of the oil presented an activity similar to that of the 100 ppm oil solution. Docking and molecular dynamics simulations verified that the interaction energies of the long-chain oil components and Ae. aegypti odorant binding protein 1 were quite favorable, indicating that the protein is a possible oviposition deterrent receptor in the antenna of Ae. aegypti.

Evaluating the abuse potential of opioids and abuse-deterrent -opioid formulations: A review of clinical study methodology.

PubMed

Setnik, Beatrice; Schoedel, Kerri A; Levy-Cooperman, Naama; Shram, Megan; Pixton, Glenn C; Roland, Carl L

With the development of opioid abuse-deterrent formulations (ADFs), there is a need to conduct well-designed human abuse potential studies to evaluate the effectiveness of their deterrent properties. Although these types of studies have been conducted for many years, largely to evaluate inherent abuse potential of a molecule and inform drug scheduling, methodological approaches have varied across studies. The focus of this review is to describe current "best practices" and methodological adaptations required to assess abuse-deterrent opioid formulations for regulatory submissions. A literature search was conducted in PubMed® to review methodological approaches (study conduct and analysis) used in opioid human abuse potential studies. Search terms included a combination of "opioid," "opiate," "abuse potential," "abuse liability," "liking," AND "pharmacodynamic," and only studies that evaluated single doses of opioids in healthy, nondependent individuals with or without prior opioid experience were included. Seventy-one human abuse potential studies meeting the prespecified criteria were identified, of which 21 studies evaluated a purported opioid ADF. Based on these studies, key methodological considerations were reviewed and summarized according to participant demographics, study prequalification, comparator and dose selection, route of administration and drug manipulation, study blinding, outcome measures and training, safety, and statistical analyses. The authors recommend careful consideration of key elements (eg, a standardized definition of a "nondependent recreational user"), as applicable, and offer key principles and "best practices" when conducting human abuse potential studies for opioid ADFs. Careful selection of appropriate study conditions is dependent on the type of ADF technology being evaluated.

Germany and the Future of Nuclear Deterrence in Europe

DTIC Science & Technology

1992-12-01

OF GERMANY PRIOR TO REUNIFICATION ........................................ 10 A. INTRODUCTION .................................... 10 B . 1945-1960...Strategic Thinking and the Role of Franz Josef Strauss ..................................... 19 b . Domestic and International Opposition ............ 23 c...63 B . UNITED KINGDOM .................................. 63 1. Background of Deterrence ........................... 64 2

The general deterrence of driving while intoxicated. Volume 2, Subsystem analyses

DOT National Transportation Integrated Search

1978-04-01

A system analysis was completed of the general deterrence of driving while intoxicated (DWI). Elements which influence DWI 'decisions were identified and interrelated in a system model; then, potential countermeasures which might be employed in DWI g...

Enforcement and public information strategies for DWI deterrence : the Indianapolis, Indiana experience

DOT National Transportation Integrated Search

1988-07-01

This report summarizes the results of a field test of attempting to achieve driving while intoxicated (DWI) general deterrence by combining enforcement efforts with public information and education (PI&E) activities designed to heighten public awaren...

Bumblebees are not deterred by ecologically relevant concentrations of nectar toxins.

PubMed

Tiedeken, Erin Jo; Stout, Jane C; Stevenson, Philip C; Wright, Geraldine A

2014-05-01

Bees visit flowers to collect nectar and pollen that contain nutrients and simultaneously facilitate plant sexual reproduction. Paradoxically, nectar produced to attract pollinators often contains deterrent or toxic plant compounds associated with herbivore defence. The functional significance of these nectar toxins is not fully understood, but they may have a negative impact on pollinator behaviour and health, and, ultimately, plant pollination. This study investigates whether a generalist bumblebee, Bombus terrestris, can detect naturally occurring concentrations of nectar toxins. Using paired-choice experiments, we identified deterrence thresholds for five compounds found in the nectar of bee-pollinated plants: quinine, caffeine, nicotine, amygdalin and grayanotoxin. The deterrence threshold was determined when bumblebees significantly preferred a sucrose solution over a sucrose solution containing the compound. Bumblebees had the lowest deterrence threshold for the alkaloid quinine (0.01 mmol l(-1)); all other compounds had higher deterrence thresholds, above the natural concentration range in floral nectar. Our data, combined with previous work using honeybees, suggest that generalist bee species have poor acuity for the detection of nectar toxins. The fact that bees do not avoid nectar-relevant concentrations of these compounds likely indicates that it is difficult for them to learn to associate floral traits with the presence of toxins, thus maintaining this trait in plant populations.

Bumblebees are not deterred by ecologically relevant concentrations of nectar toxins

PubMed Central

Tiedeken, Erin Jo; Stout, Jane C.; Stevenson, Philip C.; Wright, Geraldine A.

2014-01-01

Bees visit flowers to collect nectar and pollen that contain nutrients and simultaneously facilitate plant sexual reproduction. Paradoxically, nectar produced to attract pollinators often contains deterrent or toxic plant compounds associated with herbivore defence. The functional significance of these nectar toxins is not fully understood, but they may have a negative impact on pollinator behaviour and health, and, ultimately, plant pollination. This study investigates whether a generalist bumblebee, Bombus terrestris, can detect naturally occurring concentrations of nectar toxins. Using paired-choice experiments, we identified deterrence thresholds for five compounds found in the nectar of bee-pollinated plants: quinine, caffeine, nicotine, amygdalin and grayanotoxin. The deterrence threshold was determined when bumblebees significantly preferred a sucrose solution over a sucrose solution containing the compound. Bumblebees had the lowest deterrence threshold for the alkaloid quinine (0.01 mmol l−1); all other compounds had higher deterrence thresholds, above the natural concentration range in floral nectar. Our data, combined with previous work using honeybees, suggest that generalist bee species have poor acuity for the detection of nectar toxins. The fact that bees do not avoid nectar-relevant concentrations of these compounds likely indicates that it is difficult for them to learn to associate floral traits with the presence of toxins, thus maintaining this trait in plant populations. PMID:24526720

Judging the goring ox: retribution directed toward animals.

PubMed

Goodwin, Geoffrey P; Benforado, Adam

2015-04-01

Prior research on the psychology of retribution is complicated by the difficulty of separating retributive and general deterrence motives when studying human offenders (Study 1). We isolate retribution by investigating judgments about punishing animals, which allows us to remove general deterrence from consideration. Studies 2 and 3 document a "victim identity" effect, such that the greater the perceived loss from a violent animal attack, the greater the belief that the culprit deserves to be killed. Study 3 documents a "targeted punishment" effect, such that the responsive killing of the actual "guilty" culprit is seen as more deserved than the killing of an almost identical yet "innocent" animal from the same species. Studies 4 and 5 extend both effects to participants' acceptance of inflicting pain and suffering on the offending animal at the time of its death, and show that both effects are mediated by measures of retributive sentiment, and not by consequentialist concerns. Copyright © 2014 Cognitive Science Society, Inc.

How Bees Deter Elephants: Beehive Trials with Forest Elephants (Loxodonta africana cyclotis) in Gabon.

PubMed

Ngama, Steeve; Korte, Lisa; Bindelle, Jérôme; Vermeulen, Cédric; Poulsen, John R

2016-01-01

In Gabon, like elsewhere in Africa, crops are often sources of conflict between humans and wildlife. Wildlife damage to crops can drastically reduce income, amplifying poverty and creating a negative perception of wild animal conservation among rural people. In this context, crop-raiding animals like elephants quickly become "problem animals". To deter elephants from raiding crops beehives have been successfully employed in East Africa; however, this method has not yet been tested in Central Africa. We experimentally examined whether the presence of Apis mellifera adansonii, the African honey bee species present in Central Africa, deters forest elephants (Loxodonta Africana cyclotis) from feeding on fruit trees. We show for the first time that the effectiveness of beehives as deterrents of elephants is related to bee activity. Empty hives and those housing colonies of low bee activity do not deter elephants all the time; but beehives with high bee activity do. Although elephant disturbance of hives does not impede honey production, there is a tradeoff between deterrence and the quantity of honey produced. To best achieve the dual goals of deterring elephants and producing honey colonies must maintain an optimum activity level of 40 to 60 bee movements per minute. Thus, beehives colonized by Apis mellifera adansonii bees can be effective elephant deterrents, but people must actively manage hives to maintain bee colonies at the optimum activity level.

Transduction mechanism(s) of Na-saccharin in the blowfly Protophormia terraenovae: evidence for potassium and calcium conductance involvement.

PubMed

Masala, Carla; Solari, Paolo; Sollai, Giorgia; Crnjar, Roberto; Liscia, Anna

2009-12-01

The study on transduction mechanisms underlying bitter stimuli is a particularly intriguing challenge for taste researchers. The present study investigates, in the labellar chemosensilla of the blowfly Protophormia terraenovae, the transduction mechanism by which saccharin evokes the response of the "deterrent" cell, with particular attention to the contribution of K(+) and Ca(2+) current and the role of cyclic nucleotides, since second messengers modulate Ca(2+), Cl(-) and K(+) currents to different extents. As assessed by extracellular single-sensillum recordings, our results show that the addition of a Ca(2+) chelator such as EGTA or the Ca(2+) current blockers SK&F-96365, Mibefradil, Nifedipine and W-7 decrease the response of the "deterrent" cell to saccharin. A similar decreasing effect was also obtained following the addition of 4-aminopyridine, a K(+) current blocker. On the contrary, the membrane-permeable cyclic nucleotide 8-bromoguanosine 3',5'-cyclic monophosphate (8Br-cGMP) activates this cell and shows an additive effect when presented mixed with saccharin. Our results are consistent with the hypothesis that in the labellar chemosensilla of the blowfly both Ca(2+) and K(+) ions are involved in the transduction mechanism of the "deterrent" cell in response to saccharin. Our results also suggest a possible pathway common to saccharin and 8Br-cGMP.

How Bees Deter Elephants: Beehive Trials with Forest Elephants (Loxodonta africana cyclotis) in Gabon

PubMed Central

Ngama, Steeve; Korte, Lisa; Bindelle, Jérôme; Vermeulen, Cédric; Poulsen, John R.

2016-01-01

In Gabon, like elsewhere in Africa, crops are often sources of conflict between humans and wildlife. Wildlife damage to crops can drastically reduce income, amplifying poverty and creating a negative perception of wild animal conservation among rural people. In this context, crop-raiding animals like elephants quickly become “problem animals”. To deter elephants from raiding crops beehives have been successfully employed in East Africa; however, this method has not yet been tested in Central Africa. We experimentally examined whether the presence of Apis mellifera adansonii, the African honey bee species present in Central Africa, deters forest elephants (Loxodonta Africana cyclotis) from feeding on fruit trees. We show for the first time that the effectiveness of beehives as deterrents of elephants is related to bee activity. Empty hives and those housing colonies of low bee activity do not deter elephants all the time; but beehives with high bee activity do. Although elephant disturbance of hives does not impede honey production, there is a tradeoff between deterrence and the quantity of honey produced. To best achieve the dual goals of deterring elephants and producing honey colonies must maintain an optimum activity level of 40 to 60 bee movements per minute. Thus, beehives colonized by Apis mellifera adansonii bees can be effective elephant deterrents, but people must actively manage hives to maintain bee colonies at the optimum activity level. PMID:27196059

Abuse-Deterrent Opioid Formulations: Pharmacokinetic and Pharmacodynamic Considerations.

PubMed

Walter, Carmen; Knothe, Claudia; Lötsch, Jörn

2016-07-01

Abuse-deterrent formulations (ADFs) are technologically sophisticated pharmaceutical formulations that impede manipulation and extraction of opioids and/or provoke unpleasant effects when they are taken in excessive quantity. This is implemented by creating physical barriers, inseparably combining the opioid with an opioid antagonist or adding aversive agents to the formulation. These pharmaceutical changes may potentially alter the pharmacokinetics and consequently the pharmacodynamics of the opioid. In this review, comparative evidence on pharmacokinetic differences between abuse-deterrent and classical formulations of the same opioids is summarized; furthermore, pharmacodynamic differences, with a focus on analgesia and abuse-related symptoms, are addressed. Most of the 12 studies comparing opioid pharmacokinetics have judged the physically intact ADF as being bioequivalent to the corresponding classical formulation. Pharmacokinetic differences have, however, been reported with physically manipulated ADFs and have ranged from moderate deviations from bioequivalence to complete changes in the pharmacokinetic profile (e.g. from a sustained-release formulation to a fast-release formulation). Pharmacodynamic effects were assessed in 14 comparative studies, which reported that intact ADFs usually provided clinically equivalent analgesia and clear advantages with respect to their addiction potential. However, withdrawal symptoms could be induced by the ADFs, although rarely and, in particular, when the ADFs had been physically altered. This evidence suggests that opioid ADFs are a working concept resulting in mostly minor pharmacokinetic and pharmacodynamic differences in comparison with classical formulations; however, they may deviate from this equivalence when physically altered.

Chemical defense and chemical variation in some tropical Pacific species of Halimeda (Halimedaceae; Chlorophyta)

NASA Astrophysics Data System (ADS)

Paul, Valerie J.; van Alstyne, Kathryn L.

1988-03-01

Over a dozen species of the genus Halimeda have been chemically investigated and found to produce the diterpenoid metabolites halimedatrial (1) and halimedatetraacetate (2) in varying concentrations. These meabolites have been proposed to play a role in chemical defense against herbivores based on their chemical structures and their demonstrated biological activities in laboratory and aquarium assays. We examined and compared the feeding deterrent effects of these two compounds tovard herbivorous fishes in field experiments on Guam reefs. Halimedatrial is a more effective feeding deterrent than halimedatetraacetate. It is the major secondary metabolite in young Halimeda macroloba and in the newly produced segments of growing plants. The organic extracts from young plants and new segments were significantly more deterrent than extracts from mature plant tissue. Some populations of Halimeda growing in reef-slope habitats, where herbivory is intense, also have high concentrations of halimedatrial. We compared extracts between reef slope and reef flat collections of Halimeda opuntia on Guam and Pohnpei (= Ponape), and H. discoidea and H. macroloba on Guam. We found that halimedtrial was the major metabolite in reef-slope collections of H. opuntia from Pohnpei and Pago Bay, Guam, and that halimedatetraacetate was the major metabolite a non-reef slope populations. In the cases examined, chemical defenses were greatest in (1) plant parts and (2) populations that were at greatest risk to herbivores.

Arthropod deterrents from Artemisia pallens (Davana oil) components

USDA-ARS?s Scientific Manuscript database

Davanone, a key sesquiterpene component of davana oil, has been synthesized in five convenient steps. Oxygenated sesquiterpenes have been linked to insect deterrent properties. Based on initial screening of davana oil, davanone and its hydroxy precursors have been generated and are being evaluated...

Enforcement and public information strategies for DWI general deterrence : the Boise City, Idaho experience

DOT National Transportation Integrated Search

1987-08-01

This report summarizes the results of a field test of attempting to achieve driving while intoxicated (DWI) general deterrence by combining enforcement efforts with public information and education (PI&E) activities designed to heighten public awaren...

Use of intermediaries in DWI deterrence. Volume 1, Phase 2 report : development of intermediary programs

DOT National Transportation Integrated Search

1983-04-01

One potential approach to DWI deterrence and prevention involves encouraging people present in potential drunk driving situations to intervene in order to prevent a trip by an impaired driver. Potential "intermediaries" include service personnel in c...

Darfur: A Way Ahead

DTIC Science & Technology

2007-03-30

any actions towards solving the crisis in Darfur. Sudan is using this strategy to conduct deliberate genocidal atrocities directly against a major...solution, specific flexible deterrents, or a combination of these approaches is required to end the crisis in Darfur. Unlike the similar genocide ...campaign in Rwanda in 1994, the United States has more than a humanitarian or peripheral national interest at stake. Within the context of the War on

The Long War Concept: Using the Security Cooperation Marine Air Ground Task Force to Address Irregular Threats through Shaping and Deterrence

DTIC Science & Technology

2008-01-01

8217 relationships and alliances and/or deter potenrlal advetsaries. • PlltlSE 1: Deter the Enem ~’, This phase focuses on deterring specific opponents by...destruction of the enem ~’ in ol’der to break the opponent’s will for organized resistance. StabIllty operations WIll also be conducted as needed to

Coping with mass destruction: United States power projection in the nuclear and chemical third world. Monograph report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cheek, G.H.

1993-05-14

This monograph explores the proliferation of weapons of mass destruction in the Third World, their operational impact on power projection forces, and the viability of deterrence in the future. It concludes that the proliferation of weapons of mass destruction may have grave consequences for the power projection forces in the future; simple assumptions of non-use, reliance on our nuclear deterrent or protective measures may give us a false sense of security. Proper analysis of operational vulnerabilities will be essential for future power projection. Proliferation of operational delivery systems and weapons of mass destruction continues despite treaties and the best intentionsmore » of world leaders. Weapons of mass destruction are becoming more common throughout the world and chemical and biological weapons continue to become more and more lethal. These trends are creating a multipolar world, which history has shown to be the most unstable. This unstable world will be the environment for future power projection. Deterrence in this environment is without precedent other than the Cold War paradigm. It is questionable whether deterrence will transfer outside this paradigm as Third World nations do not have the experience, balance of power, infrastructure or political stability needed to make the concept viable. Possession of weapons of mass destruction may even allow these nations to deter entry of US power projection forces into certain regions as deterrence is a two way concept. While deterrence is still an essential part of US National Strategy to prevent war, reliance on it to prevent use of weapons of mass destruction in the midst of a conflict may prove to be a false hope.« less

Against the Corporal Punishment of Children

ERIC Educational Resources Information Center

Clark, John

2004-01-01

John Wilson suggests there are six advantages for corporal punishment: cheap and easy to administer, effective deterrent, effective reform, adjustable pain, fair because of similar dislike of pain, no permanent damage. None of these survive close scrutiny. An alternative, deontological argument against corporal punishment is proposed building on…

Deterrence at the Operational Level of War

DTIC Science & Technology

2011-01-01

edited, with Barry Blechman, Making Defense Reform Work (Brassey’s, 1990) and has also authored numerous books and articles . Deterrence at the...computational power. In contrast, many models of rational inference view the mind as if it were a supernatural being possessing demonic powers of reason

Deterrents to Participation in Web-based Continuing Professional Education.

ERIC Educational Resources Information Center

Perdue, Kathy J.; Valentine, Thomas

2000-01-01

This study examined the perceptions of certified public accountants concerning deterrents to participation in Web-based continuing professional education. Results of surveys included concerns about electronically mediated communication; the quality of course offerings; access to technology-associated resources; and the availability of necessary…

The general deterrence of driving while intoxicated. Volume 1, System analysis and computer-based simulation

DOT National Transportation Integrated Search

1978-01-01

A system analysis was completed of the general deterrence of driving while intoxicated (DWI). Elements which influence DWI decisions were identified and interrelated in a system model; then, potential countermeasures which might be employed in DWI ge...

Task force on deterrence of air piracy : final report.

DOT National Transportation Integrated Search

1978-11-01

In February 1969, as the frequency of hijacking of U.S. air carrier aircraft was rising to an all-time high, the Federal Aviation Administration established a multi-disciplinary Task Force on Deterrence of Air Piracy. The work of the Task Force in de...

Give Deterrence a Chance: A Strategy Against Al Qaeda

DTIC Science & Technology

2007-03-28

Al Qaeda Terrorists have been described as sociopaths , narcissists, fanatics, extremists, zealots, true-believers, jihadists or demented criminals...If terrorists are sociopaths or other deviants (and it is probable that some are), then it is unlikely that deterrence with its reliance on rational

Larvicidal and Biting Deterrent Activity of Essential Oils of Curcuma longa, Ar-turmerone, and Curcuminoids Against Aedes aegypti and Anopheles quadrimaculatus (Culicidae: Diptera).

PubMed

Ali, Abbas; Wang, Yan-Hong; Khan, Ikhlas A

2015-09-01

Essential oils and extract of Curcuma longa, ar-turmerone, and curcuminoids were evaluated for their larvicidal and deterrent activity against mosquitoes. Ar-turmerone and curcuminoids constituted 36.9, 24.9 and 50.6% of rhizome oil, leaf oil, and rhizome extract, respectively. Ar-turmerone was the major compound of the rhizome oil (36.9%) and leaf oil (24.9%). The ethanolic extract had 15.4% ar-turmerone with 6.6% bisdesmethoxycurcumin, 6.1% desmethoxycurcumin, and 22.6% curcumin. In in vitro studies, essential oils of the leaf (biting deterrence index [BDI] = 0.98), rhizome (BDI = 0.98), and rhizome ethanolic extract (BDI = 0.96) at 10 µg/cm(2) showed biting deterrent activity similar to DEET at 25 nmol/cm(2) against Aedes aegypti L. Among the pure compounds, ar-turmerone (BDI = 1.15) showed the biting deterrent activity higher than DEET at 25 nmol/cm(2) whereas the activity of other compounds was lower than DEET. In Anopheles quadrimaculatus Say, only ar-turmerone showed deterrent activity similar to DEET. In dose-response bioassay, ar-turmerone showed significantly higher biting deterrence than DEET at all the dosages. Ar-turmerone, at 15 nmol/cm(2), showed activity similar to DEET at 25 nmol/cm(2) and activity at 5 nmol/cm(2) was similar to DEET at 20 and 15 nmol/cm(2). Leaf essential oil with LC(50) values of 1.8 and 8.9 ppm against larvae of An. quadrimaculatus and Ae. aegypti, respectively, showed highest toxicity followed by rhizome oil and ethanolic extract. Among the pure compounds, ar-turmerone with LC(50) values of 2.8 and 2.5 ppm against larvae of An. quadrimaculatus and Ae. aegypti, respectively, was most toxic followed by bisdesmethoxycurcumin, curcumin, and desmethoxycurcumin. © The Authors 2015. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Nuclear weapons, irrational behavior, and extended deterrence

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rhodes, E.J.

1985-01-01

This dissertation examines the problem of extended deterrence deductively develops a theory of commitment-through-contingent irrationality, and draws upon this theory to frame a set of comparatively attractive policy recommendations. To these ends, the dissertation explores the nature, sources, and types of irrationality and irrational behavior, the necessary and sufficient conditions for the existence of coercive power, the various logical modes of commitment, and the various modes of nuclear coercion. These strands are fused into a theory of nuclear coercion based on contingently irrational behavior that has relevance for the problem of extended deterrence and that has important implications for USmore » policy.« less

An evaluation of the general deterrent effect of vehicle impoundment on suspended and revoked drivers in California

DOT National Transportation Integrated Search

2000-04-01

While license suspension/revocation have been shown to be effective, it is also known that most suspended/revoked (S/R) drivers violate their S/R order and continue to drive, accruing traffic convictions and becoming involved in crashes. In an attemp...

Effective Prevention of Adolescent Substance Abuse--Educational versus Deterrent Approaches

ERIC Educational Resources Information Center

Tze, Virginia M. C.; Li, Johnson C.-H.; Pei, Jacqueline

2012-01-01

Substance abuse, especially among adolescents, has long been an important issue in society. In light of the adverse impact of substance abuse, scholars, educators, and policy-makers have proposed different approaches to prevent and reduce such abuse. This paper investigates the effectiveness of the two prominent approaches--educational and…

Performance Outcomes of an Online First Aid and CPR Course for Laypersons

ERIC Educational Resources Information Center

Cason, Carolyn L.; Stiller, Janeth

2011-01-01

Objective: The study evaluated the effectiveness of an online first aid course by comparing it with the traditional instructor-led course. An effective online course increases course accessibility and mitigates the major deterrent to widespread layperson training. Design: A comparison group design evaluated performances among 25 laypersons…

Impact of abuse-deterrent OxyContin on prescription opioid utilization.

PubMed

Hwang, Catherine S; Chang, Hsien-Yen; Alexander, G Caleb

2015-02-01

We quantified the degree to which the August 2010 reformulation of abuse-deterrent OxyContin affected its use, as well as the use of alternative extended-release and immediate-release opioids. We used the IMS Health National Prescription Audit, a nationally representative source of prescription activity in the USA, to conduct a segmented time-series analysis of the use of OxyContin and other prescription opioids. Our primary time period of interest was 12 months prior to and following August 2010. We performed model checks and sensitivity analyses, such as adjusting for marketing and promotion, using alternative lag periods, and adding extra observation points. OxyContin sales were similar before and after the August 2010 reformulation, with approximately 550 000 monthly prescriptions. After adjusting for declines in the generic extended-release oxycodone market, the formulation change was associated with a reduction of approximately 18 000 OxyContin prescription sales per month (p = 0.02). This decline corresponded to a change in the annual growth rate of OxyContin use, from 4.9% prior to the reformulation to -23.8% during the year after the reformulation. There were no statistically significant changes associated with the sales of alternative extended-release (p = 0.42) or immediate-release (p = 0.70) opioids. Multiple sensitivity analyses supported these findings and their substantive interpretation. The market debut of abuse-deterrent OxyContin was associated with declines in its use after accounting for the simultaneous contraction of the generic extended-release oxycodone market. Further scrutiny into the effect of abuse-deterrent formulations on medication use and health outcomes is vital given their popularity in opioid drug development. Copyright © 2014 John Wiley & Sons, Ltd.

Do deterrence and social-control theories predict driving after drinking 15 years after a DWI conviction?

PubMed

Lapham, Sandra C; Todd, Michael

2012-03-01

This study investigates the utility of deterrence and social-control theories for prospective prediction of driving-while-impaired (DWI) outcomes of first-time DWI offenders. The sample consisted of a subset of 544 convicted first-time DWI offenders (N=337 females) who were interviewed 5 and 15 years after referral to a Screening Program in Bernalillo County, New Mexico. Variables collected at the 5-year (initial) interview were used in structural equation models to predict past 3-months, self-reported DWI at the 15-year follow-up (follow-up) interview. These variables represented domains defined by deterrence and social-control theories of DWI behavior, with one model corresponding to deterrence theory and one to social-control theory. Both models fit the data. DWI jail time was positively related to perceived enforcement, which was negatively but not significantly related to self-reported DWI. Neither jail time for DWI nor perceived likelihood of arrest was linearly related to self-reported DWI at follow-up. Interactions between jail time and prior DWI behavior indicated relatively weaker associations between initial and 15-year DWI for those reporting more jail time. Our prospective study demonstrated that for this convicted DWI offender cohort, classic formulations of deterrence and social-control theories did not account for DWI. However, results suggest that punishment may decrease the likelihood of DWI recidivism. Copyright © 2012 Elsevier Ltd. All rights reserved.

Frequency modulation for a wind turbine blade-mounted ultrasonic bat deterrent

NASA Astrophysics Data System (ADS)

Carlson, Daniel; Dowling, Zara; Sievert, Paul; Modarres-Sadeghi, Yahya

2017-11-01

Progress on developing a bat deterrent device for placement on the rotating blades of a wind turbine is presented. The mechanisms by which bat larynxes generate ultrasound is studied and reproduced experimentally. In previous iterations, flow-induced oscillations have been used to generate ultrasonic frequencies within the 20-70 kHz range: a range which laboratory studies have shown can deter bats from an area. However, the present work considers mechanisms which result in frequency modulation within the higher harmonics, an acoustic signal closer to what bats naturally avoid. Results discussed include the effects of spanwise tension on the flapwise oscillation of a pseudo larynx in flow, and how shifting the flapwise natural frequency allows frequency modulation. The net effect is a device effective within the range of wind speeds encountered along the length of a rotating wind turbine blade. The authors wish to acknowledge support by the National Science Foundation Offshore Wind Energy IGERT at the University of Massachusetts, Amherst, Grant Number 1068864.

Endogenous and costly institutional deterrence

Treesearch

David C. Kingsley; Thomas C. Brown

2014-01-01

Modern economies rely on central-authority institutions to regulate individual behaviour. Despite the importance of such institutions little is known about their formation within groups. In a public good experiment, groups selected the level of deterrence implemented by the institution, knowing that the administrative costs of the institution rose with the level of...

Use of intermediaries in DWI deterrence. Volume 2, Phase 1 report : analysis of potential target clusters for DWI intermediary programs

DOT National Transportation Integrated Search

1983-04-01

This report summarizes the results of Phase I of the project, "Use of Intermediaries in DWI Deterrence." Data from secondary sources along with National Accident Samplimg System (NASS), Fatal Accident Reporting System (FARS) and National Institute on...

Deterrents to Women's Participation in Continuing Professional Development

ERIC Educational Resources Information Center

Chuang, Szu-Fang

2015-01-01

This study was designed to explore and define key factors that deter women from participating in continuing professional development (CPD) in the workplace. Four dimensions of deterrents that are caused by women's social roles, gender inequality and gender dimensions are discussed: family and time constraints, cost and work constraints, lack of…

Convenience, the bane of our existence, and other barriers to donating.

PubMed

Schreiber, George B; Schlumpf, Karen S; Glynn, Simone A; Wright, David J; Tu, Yongling; King, Melissa R; Higgins, Martha J; Kessler, Debra; Gilcher, Ronald; Nass, Catharie C; Guiltinan, Anne M

2006-04-01

To prevent donor loss and improve retention, it is important to understand the major deterrents to blood donation and to identify factors that can be effectively addressed by blood centers. A 30-item self-administered questionnaire was completed in 2003 by 1705 first-time and 2437 repeat US donors who had not donated in 2 to 3 years. Asian, Hispanic, black, and white first-time and repeat donors rated the importance of deterrents to donation in their decision to not return with a 1 to 5 scale. Categorical analysis of variance methods were used to compare the importance of deterrents between first-time and repeat donors of different race or ethnicity. Not having a convenient place to donate was most commonly cited as an important or very important reason for not returning by 32 to 42 percent of first-time and 26 to 43 percent of repeat respondents. Although bad treatment and poor staff skills were less of a barrier than convenience, they were more important for minority donors. Other factors such as physical side effects, foreign travel, or length of the process appeared less important. Inconvenience is a major barrier to donating, suggesting that mobile collections and increased hours of operation might help recapture lapsed donors. The finding that lapsed minority donors were more likely to give bad treatment and poor staff skills as important reasons to not donate is disconcerting in light of the changing donor demographics and increased efforts to recruit these donors.

Impact of Deterrents on Effectiveness of Mandatory Continuing Professional Education for Company Secretaries in India

ERIC Educational Resources Information Center

Walawalkar, Rajesh

2015-01-01

This study is about the perceptions of Company Secretaries about effectiveness of their formal and mandatory Continuing Professional Education (CPE) programme run by the Institute of Company Secretaries of India. The objectives were to ascertain: (1) to what extent do Company Secretaries perceive their CPE as effective, (2) what are the various…

Integrating nuclear weapons stockpile management and nuclear arms control to enable significant stockpile reductions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sanders, Lani Miyoshi; DeLand, Sharon M.; Pregenzer, Arian L.

2010-11-01

In his 2009 Prague speech and the 2010 Nuclear Posture Review, President Barack Obama committed the United States to take concrete steps toward nuclear disarmament while maintaining a safe, secure, and effective nuclear deterrent. There is an inherent tension between these two goals that is best addressed through improved integration of nuclear weapons objectives with nuclear arms control objectives. This article reviews historical examples of the interaction between the two sets of objectives, develops a framework for analyzing opportunities for future integration, and suggests specific ideas that could benefit the nuclear weapons enterprise as it undergoes transformation and that couldmore » make the future enterprise compatible with a variety of arms control futures.« less

Follow-up evaluation of Wisconsin's 1982 drinking and driving law

DOT National Transportation Integrated Search

1988-09-01

A previous study examined the deterrent effects of Wisconsin's 1982 law mandating three to six month license suspension for first-time convicted drinking drivers. This earlier study found that: crashes and violations were reduced during the first thr...

Confidence in Nuclear Weapons as Numbers Decrease and Time Since Testing Increases

NASA Astrophysics Data System (ADS)

Adams, Marvin

2011-04-01

As numbers and types of nuclear weapons are reduced, the U.S. objective is to maintain a safe, secure and effective nuclear deterrent without nuclear-explosive testing. A host of issues combine to make this a challenge. An evolving threat environment may prompt changes to security systems. Aging of weapons has led to ``life extension programs'' that produce weapons that differ in some ways from the originals. Outdated and changing facilities pose difficulties for life-extension, surveillance, and dismantlement efforts. A variety of factors can make it a challenge to recruit, develop, and retain outstanding people with the skills and experience that are needed to form the foundation of a credible deterrent. These and other issues will be discussed in the framework of proposals to reduce and perhaps eliminate nuclear weapons.

Received and perceived social support in times of stress: a test of the social support deterioration deterrence model.

PubMed

Norris, F H; Kaniasty, K

1996-09-01

The authors evaluated the impact of receiving social support on subsequent levels of perceived social support and psychological distress in 2 independent samples of victims of severe natural disasters: Hurricane Hugo (n = 498) and Hurricane Andrew (n = 404). A social support deterioration deterrence model was proposed that stipulated that postdisaster mobilization of received support counteracts the deterioration in expectations of support often experienced by victims of major life events. LISREL analyses of data collected 12 and 24 months after Hugo and 6 and 28 months after Andrew provided strong evidence for the hypothesized model: Perceived support mediated the long-term effects on distress of both scope of disaster exposure and postdisaster received support. Theoretical and application issues of social support are discussed.

A Biomimetic Ultrasonic Whistle for Use as a Bat Deterrent on Wind Turbines

NASA Astrophysics Data System (ADS)

Sievert, Paul; Seyed-Aghazadeh, Banafsheh; Carlson, Daniel; Dowling, Zara; Modarres-Sadeghi, Yahya

2016-11-01

As wind energy continues to gain worldwide prominence, more and more turbines are detrimentally influencing bat colonies. In 2012 alone, an estimated 600,000 bats were killed by wind turbines in the United States. Bats show a tendency to fly towards turbines. The objective of this work is to deter bats from the proximity of the swept area of operational wind turbine blades. Established field studies have shown that bats avoid broadband ultrasonic noise on the same frequency spectrum as their echolocation chirps. A biomimetic ultrasonic pulse generator for use as a bat deterrent on wind turbines is designed and studied experimentally. This device, which works based on the fundamentals of flow-induced oscillations of a flexible sheet is a whistle-like device inspired by a bat larynx, mechanically powered via air flow on a wind turbine blade. Current device prototypes have proven robust at producing ultrasound across the 20 - 70 kHz range for flow inlet velocities of 4 - 14 m/s. Ultimately, a deterrent as described here could provide a reliable, cost-effective means of alerting bats to the presence of moving turbine blades, reducing bat mortality at wind facilities, and reducing regulatory uncertainty for wind facility developers. The financial support provided by the US Department of Energy, and the Massachusetts Clean Energy center is acknowledged.

Callicarpenal and Intermedeol: Two Natural Arthropod Feeding Deterrent and Repellent Compounds Identified from the Southern Folk Remedy Plant, Callicarpa americana

USDA-ARS?s Scientific Manuscript database

In previous studies on the American beautyberry (Callicarpa americana), it was demonstrated that callicarpenal and intermedeol were responsible for the arthropod repellent and feeding deterrent activity of this folk remedy. Both compounds showed significant bite-deterring activity against Aedes aeg...

2015 Cross-Domain Deterrence Seminar Summary Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Juarez, A.

2016-01-11

Lawrence Livermore National Laboratory (LLNL) hosted the 2nd Annual Cross-Domain Deterrence Seminar on November 17th, 2015 in Livermore, CA. The seminar was sponsored by LLNL’s Center for Global Security Research (CGSR), National Security Office (NSO), and Global Security program. This summary covers the seminar’s panels and subsequent discussions.

American Naval Policy, Strategy, Plans and Operations in the Second Decade of the Twenty first Century

DTIC Science & Technology

2017-01-01

13 Maritime safety ...deterrence, ballistic missile defense, deterrence of conventional crises and war (through naval readiness and engagement), maritime safety operations...confidence-building measure and to avoid unwanted crises.55 Maritime safety This an area that is primarily the domain of the world’s Coast Guards

Isolation and identification of mosquito (Aedes aegypti) biting deterrent fatty acids from male inflorescences of breadfruit (Artocarpus altilis (Parkinson)Fosberg)

USDA-ARS?s Scientific Manuscript database

Dried male inflorescences of breadfruit (Artocarpus altilis, Moraceae) are burned in communities throughout Oceania to repel flying insects, including mosquitoes. This study was conducted to identify chemicals responsible for mosquito deterrence. Various crude extracts were evaluated, and the most a...

An Application of the Social Support Deterioration Deterrence Model to Rescue Workers

ERIC Educational Resources Information Center

Prati, Gabriele; Pietrantoni, Luca

2010-01-01

This study examined the role of social support in promoting quality of life in the aftermath of critical incidents involvement. Participants were a sample of 586 Italian rescue workers. Structural equation modelling was used to test the social support deterioration deterrence model. Results showed that the impact of critical incident involvement…

The nuclear dilemma and the just war tradition

DOE Office of Scientific and Technical Information (OSTI.GOV)

O'Brien, W.V.; Langan, J.

This book presents papers on the ethical aspects of nuclear weapons. Topics considered include the concept of a ''just'' war, national defense, political aspects, religion and politics, the failure of deterrence, conventional warfare, nuclear deterrence and democratic politics, the future of the nuclear debate, non-proliferation policy, arms control, national security, and government policies.

Risk based In Vitro Performance Assessment of Extended Release Abuse Deterrent Formulations

PubMed Central

Xu, Xiaoming; Gupta, Abhay; Al-Ghabeish, Manar; Calderon, Silvia N.; Khan, Mansoor A.

2016-01-01

High strength extended release opioid products, which are indispensable tools in the management of pain, are associated with serious risks of unintentional and potentially fatal overdose, as well as of misuse and abuse that might lead to addiction. The issue of drug abuse becomes increasingly prominent when the dosage forms can be readily manipulated to release a high amount of opioid or to extract the drug in certain products or solvents. One approach to deter opioid drug abuse is by providing novel abuse deterrent formulations (ADF), with properties that may be viewed as barriers to abuse of the product. However, unlike regular extended release formulations, assessment of ADF technologies are challenging, in part due to the great variety of formulation designs available to achieve deterrence of abuse by oral, parenteral, nasal and respiratory routes. With limited prior history or literature information, and lack of compendial standards, evaluation and regulatory approval of these novel drug products become increasingly difficult. The present article describes a risk-based standardized in-vitro approach that can be utilized in general evaluation of abuse deterrent features for all ADF products. PMID:26784976

In Vitro and In Vivo Evaluation of Infestation Deterrents Against Lice

PubMed Central

Yoon, Kyong Sup; Ketzis, Jennifer K.; Andrewes, Samuel W.; Wu, Christopher S.; Honraet, Kris; Staljanssens, Dorien; Rossel, Bart; Marshall Clark, J.

2015-01-01

The human head louse is a cosmopolitan ectoparasite and frequently infests many people, particularly school-age children. Due to widespread pyrethroid resistance and the lack of efficient resistance management, there has been a considerable interest in the protection of uninfested people and prevention of reinfestation by disrupting lice transfer. In this study, two nonclinical model systems (in vitro and in vivo) were used to determine the efficacy of the infestation deterrents, Elimax lotion and Elimax shampoo, against human head lice or poultry chewing lice, respectively. With in vitro assessments, female head lice exhibited significantly higher avoidance responses to hair tufts treated with either of the test formulations, which led to significantly higher ovipositional avoidance when compared with female lice on control hair tufts. Additionally, both formulations were determined to be competent infestation deterrents in a competitive avoidance test in the presence of a known attractant (head louse feces extract). In in vivo assessments using a previously validated poultry model, Elimax shampoo was determined to be an efficacious deterrent against poultry chewing lice within Menopon spp. and Menacanthus spp. PMID:26336209

Physical characteristics of Medicago truncatula calcium oxalate crystals determine their effectiveness in insect defense

USDA-ARS?s Scientific Manuscript database

Plant structural traits can act as defense against herbivorous insects, causing them to avoid feeding on a given plant or tissue. Mineral crystals of calcium oxalate in leaves of Medicago truncatula Gaertn. have previously been shown to be effective deterrents of lepidopteran insect feeding. They ar...

Thinking Globally about U.S. Extended Deterrence

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roberts, Brad; Santoro, David; Volpe, Tristan

In contrast to the Cold War bilateral global competition between the United States and the Soviet Union, the modern nuclear age features a more complex, multiplayer arena on the regional scale. With the exception of the U.S. and Russia, most major powers retain relatively small nuclear arsenals or technical hedge capabilities. The U.S., with strong interests and security partnerships in Europe, Northeast Asia, and the Middle East, must navigate through long-standing rivalries and active conflicts while attempting to divine the intentions of less experienced nuclear decision makers in charge of weak domestic institutions. As a result, analysts and policymakers mustmore » think globally about U.S. extended deterrence. How have the requirements of extended deterrence and assurance changed? Are there important threads that connect each region? What should the U.S. do differently? To explore these questions, Lawrence Livermore National Laboratory’s Center for Global Security Research, in partnership with the Carnegie Endowment for International Peace and the Pacific Forum CSIS, held a workshop on “Thinking Globally about U.S. Extended Deterrence” in Washington, DC on November 2, 2015. The workshop brought together approximately 40 U.S. and foreign deterrence specialists and government officials, all attending in their private capacities. The participants joined a day of not-for-attribution discussions on the changing deterrence and assurance requirements, the threads that connect the regions, and U.S. strategy to deal with emerging challenges. The following is a summary of key takeaways.« less

Opioids with abuse-deterrent properties: A regulatory and technological overview.

PubMed

Haddox, J David

Three concurrent public health problems coexist in the United States: endemic nonmedical use/misuse of opioid analgesics, epidemic overdose fatalities involving opioid analgesics, and endemic chronic pain in adults. These intertwined issues comprise an opioid crisis that has spurred the development of formulations of opioids with abuse-deterrent properties and label claims (OADP). To reduce abuse and misuse of prescription opioids, the federal Food and Drug Administration (FDA) has issued a formal Guidance to drug developers that delineates four categories of testing to generate data sufficient for a description of a product's abuse-deterrent properties, along with associated claims, in its Full Prescribing Information (FPI). This article reviews the epidemiology of the crisis as background for the development of OADP, summarizes the FDA Guidance for Industry regarding abuse-deterrent technologies, and provides an overview of some technologies that are currently employed or are under study for incorporation into OADP. Such technologies include physical and chemical barriers to abuse, combined formulations of opioid agonists and antagonists, inclusion of aversive agents, use of delivery systems that deter abuse, development of new molecular entities and prodrugs, and formulation of products that include some combination of these approaches. Opioids employing these novel technologies are one part of a comprehensive intervention strategy that can deter abuse of prescription opioid analgesics without creating barriers to the safe use of prescription opioids. The maximal public health contribution of OADP will probably occur only when all opioids have FDA-recognized abuse-deterrent properties and label claims.

Dose-dependent effects of nectar alkaloids in a montane plant-pollinator community

USDA-ARS?s Scientific Manuscript database

Although secondary metabolites are prevalent in floral nectar, the ecological consequences for pollinators and pollination remain relatively unexplored. While often deterrent to pollinators at high concentrations, secondary metabolite concentrations in nectar tend to be much lower than secondary met...

International approaches to driving under the influence of cannabis: A review of evidence on impact.

PubMed

Watson, Tara Marie; Mann, Robert E

2016-12-01

There are knowledge gaps regarding the effectiveness of different approaches designed to prevent and deter driving under the influence of cannabis (DUIC). Policymakers are increasingly interested in evidence-based responses to DUIC as numerous jurisdictions worldwide have legally regulated cannabis or are debating such regulation. We contribute a comprehensive review of international literature on countermeasures that address DUIC, and identify where and how such measures have been evaluated. The following databases were systematically searched from 1995 to present: Medline, Embase, PsycINFO, CINAHL, Sociological Abstracts, and Criminal Justice Abstracts. Hand searching of relevant documents, internet searches for grey literature, and review of ongoing email alerts were conducted to capture any emerging literature and relevant trends. Numerous international jurisdictions have introduced a variety of measures designed to deter DUIC. Much interest has been generated regarding non-zero per se laws that set fixed legal limits for tetrahydrocannabinol and/or its metabolites detected in drivers. Other approaches include behavioural impairment laws, zero-tolerance per se laws, roadside drug testing, graduated licensing system restrictions, and remedial programs. However, very few evaluations have appeared in the literature. Although some promising results have been reported (e.g., roadside testing), it is premature to draw firm conclusions regarding the broader impacts of general deterrent approaches to DUIC. This review points to the need for a long-term commitment to rigorously evaluate, using multiple methods, the impact of general and specific deterrent DUIC countermeasures. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

The International Politics of Peace Education: The Conflict between Deterrence and Disarmament.

ERIC Educational Resources Information Center

Willers, Jack Conrad

The main impetus for peace education is the arms race, which places peace education in the conflict between conservatives advocating increased nuclear deterrence and liberals supporting nuclear disarmament. In the United States, education for peace is still in its infancy. Other developed nations, such as the Scandinavian countries and to a lesser…

Bioassay-guided isolation and identification of Aedes aegypti larvicidal and biting deterrent compounds from Veratrum lobelianum

USDA-ARS?s Scientific Manuscript database

An ethanol extract from Veratrum lobelianum Bernh. rhizomes was evaluated for biting deterrent and larvicidal activity against Aedes aegypti. V. lobelianum extract showed larvicidal activity with LC50 values of 11.79 ppm and 89.9 ppm against 1st and 4th instar larvae, respectively, at 24 h post-trea...

Rationality, Culture and Deterrence

DTIC Science & Technology

2013-09-01

Postgraduate School Center on Contemporary Conflict is the research wing of the Department of National Security Affairs ( NSA ) and specializes in the...and neuroscience . None of these approaches, either alone or in combination, offers a perfect framework for predicting the outcomes of deterrence...constructivism, approaches based on domestic and bureaucratic politics, and behavioral approaches drawn from findings in psychology and neuroscience

Strengthening Deterrence for 21st Century Strategic Conflicts and Competition: Accelerating Adaptation and Integration - Annotated Bibliography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roberts, B.; Durkalec, J. J.

This was the fourth in a series of annual events convened at Livermore to exploring the emerging place of the “new domains” in U.S. deterrence strategies. The purposes of the series are to facilitate the emergence of a community of interest that cuts across the policy, military, and technical communities and to inform laboratory strategic planning. U.S. allies have also been drawn into the conversation, as U.S. deterrence strategies are in part about their protection. Discussion in these workshops is on a not-for-attribution basis. It is also makes no use of classified information. On this occasion, there were nearly 100more » participants from a dozen countries.« less

Moral and morale benefits of the Strategic Defense Initiative. Student report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Poston, J.R.

1986-04-01

This writer finds strategic defense a moral advance over the present nuclear deterrence policy as well as a probable boost to national and military morale because of the broad-based popular support attendant to the inherent moral suasion. Popular support is nearly inevitable because of the moral superiority of strategic defense over nuclear retaliation, as well as the sheer compulsion of common sense about a protective defense. Criticism of the SDI abounds, but not without adequate answers from proponents. One of the best morale-building supports for those experiencing mixed moral feelings about nuclear deterrence is that strategic defense avoids or pointsmore » to a way out of the moral problems facing nuclear deterrence and its grim companion--nuclear retaliation.« less

Gender and stereotypes in motivation to study computer programming for careers in multimedia

NASA Astrophysics Data System (ADS)

Doubé, Wendy; Lang, Catherine

2012-03-01

A multimedia university programme with relatively equal numbers of male and female students in elective programming subjects provided a rare opportunity to investigate female motivation to study and pursue computer programming in a career. The MSLQ was used to survey 85 participants. In common with research into deterrence of females from STEM domains, females displayed significantly lower self-efficacy and expectancy for success. In contrast to research into deterrence of females from STEM domains, both genders placed similar high values on computer programming and shared high extrinsic and intrinsic goal orientation. The authors propose that the stereotype associated with a creative multimedia career could attract female participation in computer programming whereas the stereotype associated with computer science could be a deterrent.

Nucleophile sensitivity of Drosophila TRPA1 underlies light-induced feeding deterrence

PubMed Central

Du, Eun Jo; Ahn, Tae Jung; Wen, Xianlan; Seo, Dae-Won; Na, Duk L; Kwon, Jae Young; Choi, Myunghwan; Kim, Hyung-Wook; Cho, Hana; Kang, KyeongJin

2016-01-01

Solar irradiation including ultraviolet (UV) light causes tissue damage by generating reactive free radicals that can be electrophilic or nucleophilic due to unpaired electrons. Little is known about how free radicals induced by natural sunlight are rapidly detected and avoided by animals. We discover that Drosophila Transient Receptor Potential Ankyrin 1 (TRPA1), previously known only as an electrophile receptor, sensitively detects photochemically active sunlight through nucleophile sensitivity. Rapid light-dependent feeding deterrence in Drosophila was mediated only by the TRPA1(A) isoform, despite the TRPA1(A) and TRPA1(B) isoforms having similar electrophile sensitivities. Such isoform dependence re-emerges in the detection of structurally varied nucleophilic compounds and nucleophilicity-accompanying hydrogen peroxide (H2O2). Furthermore, these isoform-dependent mechanisms require a common set of TRPA1(A)-specific residues dispensable for electrophile detection. Collectively, TRPA1(A) rapidly responds to natural sunlight intensities through its nucleophile sensitivity as a receptor of photochemically generated radicals, leading to an acute light-induced behavioral shift in Drosophila. DOI: http://dx.doi.org/10.7554/eLife.18425.001 PMID:27656903

What's the Rush? Tort Laws and Elective Early-term Induction of Labor.

PubMed

Roth, Louise Marie

2016-12-01

Tort laws aim to deter risky medical practices and increase accountability for harm. This research examines their effects on deterrence of a high-risk obstetric practice in the United States: elective early-term (37-38 weeks gestation) induction of labor. Using birth certificate data from the Natality Detail Files and state-level data from publicly available sources, this study analyzes the effects of tort laws on labor induction with multilevel models (MLM) of 665,491 early-term births nested in states. Results reveal that caps on damages are associated with significantly higher odds of early-term induction and Proportionate Liability (PL) is associated with significantly lower odds compared to Joint and Several Liability (JSL). The findings suggest that clinicians are more likely to engage in practices that defy professional guidelines in tort environments with lower legal burdens. I discuss the implications of the findings for patient safety and the deterrence of high-risk practices. © American Sociological Association 2016.

Reactions to mandatory sentences in relation to the ethnic identity and criminal history of the offender.

PubMed

Feather, N T; Souter, Jacqueline

2002-08-01

This study investigated the responses of 181 participants (87 men, 94 women), from Adelaide, South Australia, to scenarios describing mandatory sentences for perpetrators of a property offense committed in the Northern Territory, Australia. Four scenarios that were randomly distributed varied ethnic identity (White Australian, Aboriginal Australian) and criminal history (first-time offender, third-time offender). Participants completed attitude measures for both mandatory sentencing and capital punishment, a right-wing authoritarianism scale, and a scale concerned with sentencing goals (retribution, deterrence, protection of society, and rehabilitation). Results showed strong effects of attitude toward mandatory sentencing on scenario responses for variables such as perceived responsibility, deservingness, leniency, seriousness, anger and pleasure, and weaker effects of ethnic identity and criminal history. Participants were generally more sympathetic when the offender was an Aboriginal Australian. Results of a multiple regression analysis showed that attitude toward mandatory sentence was predicted by right-wing authoritarianism and by sentencing goals relating to deterrence and the protection of society.

Adolescent Drug Use and the Deterrent Effect of School-Imposed Penalties

ERIC Educational Resources Information Center

Waddell, G. R.

2012-01-01

Estimates of the effect of school-imposed penalties for drug use on a student's consumption of marijuana are biased if both are determined by unobservable school or individual attributes. Reverse causality is also a potential challenge to retrieving estimates of the causal relationship, as the severity of school sanctions may simply reflect the…

Nuclear weapons are illegal threats

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meyrowitz, E.L.

Challenging Harry Almond's position that nuclear deterrence is workable, the author contends that there is no historical basis for believing that anticipation of the horrors of war will be an effective deterrent. He questions the belief that the nuclear balance of terror has maintained the peace for the past 40 years because an arms race is inherently unstable. The argument that the pursuit of national interests takes precedence over any limitation imposed by international law reflects a perception of international law that is comparable to the Third Reich. The bases for a legal evaluation of the status of nuclear weaponsmore » under international law come from express and implicit treaty provisions, international custom, general principles of international law, judicial decisions, resolutions at the United Nations, and the opinions of qualified jurists as well as military necessity.« less

Improve medical malpractice law by letting health care insurers take charge.

PubMed

Reinker, Kenneth S; Rosenberg, David

2011-01-01

This essay discusses unlimited insurance subrogation (UIS) as a means of improving the deterrence and compensation results of medical malpractice law. Under UIS, health care insureds could assign their entire potential medical malpractice claims to their first-party commercial and government insurers. UIS should improve deterrence by establishing first-party insurers as plaintiffs to confront liability insurers on the defense side, leading to more effective prosecution of meritorious claims and reducing meritless and unnecessary litigation. UIS should improve compensation outcomes by converting litigation cost- and risk- laden "tort insurance" into cheaper and enhanced first-party insurance. UIS also promises dynamic benefits through further reforms by contract between the first-party and liability insurers that would take charge of system. No UIS-related costs are apparent that would outweigh these benefits. © 2011 American Society of Law, Medicine & Ethics, Inc.

Responses of invasive silver and bighead carp to a carbon dioxide barrier in outdoor ponds

USGS Publications Warehouse

Cupp, Aaron R.; Erickson, Richard A.; Fredricks, Kim T.; Swyers, Nicholas M.; Hatton, Tyson; Amberg, Jon J.

2017-01-01

Resource managers need for effective methods to prevent the movement of silver (Hypophthalmichthys molitrix) and bighead carp (H. nobilis) from the Mississippi River basin into the Laurentian Great Lakes. In this study, we evaluated dissolved carbon dioxide (CO2) as a barrier and deterrent to silver (278 ± 30.5 mm) and bighead (212 ± 7.7 mm) carp movement in continuous-flow outdoor ponds. As a barrier, CO2 significantly reduced upstream movement but was not 100% effective at blocking fish passage. As a deterrent, we observed a significant shift away from areas of high CO2 relative to normal movement before and after injection. Carbon dioxide concentrations varied across the pond during injection and reached maximum concentrations of 74.5±1.9 mg/L CO2; 29 532 – 41 393 µatm at the site of injection during three independent trials. We conclude that CO2 altered silver and bighead carp movement in outdoor ponds and recommend further research to determine barrier effectiveness during field applications.

Deterrents to Nurses' Participation in Continuing Professional Education as Perceived by Licensed Nurses in Oklahoma

ERIC Educational Resources Information Center

Fahnestock, Annetta Bethene

2012-01-01

Little is known about the deterrents to licensed nurses' participation in continuing professional education (CPE) in Oklahoma, the licensed nurses' preferred method for obtaining CPE, and the ways in which employers support participation in CPE. A random sample of 78 licensed nurses in Oklahoma completed a 20 item questionnaire and a 40 item…

PRISM

DTIC Science & Technology

2017-12-21

deterrence approach is capable of exer- cising deterrence with virtual, psychological , moral, and physical aspects in an integrated way, thus lever...Julie Ryan T H E F I F T H D O M A I N Integrating cyber and electronic warfare capabilities increases the commander’s situational awareness. (U.S...cyber organizations and the interagency; and integrating cyber requirements into operational planning and execution. It will take continued

U.S. Army Training in the Tactical Employment of Chemical Weapons: A flaw in Our Chemical Deterrence?

DTIC Science & Technology

1988-12-09

y horse drawn milltary 𔃾 transportation system A.3 Germany began to suffer reverses In Fance .wld on tlt . front, Hitler, who initially had been...September 1987. Rogers, Gen Bernard. Interview. "Chemical Deterrence is Imperative". _ National Guard, March 1985, p. 27-8. Segal, David. ’Soviet Union’s

French Nuclear Strategy in an Age of Terrorism

DTIC Science & Technology

2006-12-01

PAGES 115 14. SUBJECT TERMS French Nuclear Strategy, Deterrence, Nuclear Doctrine, France , European Nuclear Deterrence, Franco-American Relations...Certain Idea of France (Princeton, NJ: Princeton University Press, 1993); Wilfrid L Kohl, French Nuclear Diplomacy (Princeton, NJ: Princeton University...nuclear program. 1. A Nuclear France : Inception of the force de frappe The French nuclear program started during the Fourth Republic, immediately

A U.S. Minimum Nuclear Deterrence Strategy: By Design or Default It’s about the Policy Options

DTIC Science & Technology

2012-06-01

then who are we to suggest actions that may upset the apple cart. Continued Retention of a Nuclear Deterrence Force. The ideas of M. K. Ghandi ...shaped India’s thinking about nuclear weapons. Ghandi espoused non-violence as a political strategy and his moral rejection of nuclear weapons laid the

Abuse-deterrent formulations: transitioning the pharmaceutical market to improve public health and safety

PubMed Central

Worthy, Stacey L.; Barnes, Michael C.; Tarbell, Benjamin

2015-01-01

This article evaluates abuse-deterrent formulations (ADFs) as a method to reduce prescription drug abuse while ensuring access to vital medications for individuals with legitimate need; assesses the pros and cons of ADFs and the current state of ADF adoption in the market; and develops policy recommendations to transition the market to ADFs. Although abuse-deterrent technology is still in its nascent stages, ADFs have been proven to reduce prescription drug abuse and its consequences, and even an incremental reduction in abuse can have a significant impact on the nation by reducing the costly social, physical, mental, and public health problems resulting from abuse. Federal ADF policy does not reflect the urgency of the prescription drug abuse epidemic and does not go far enough toward changing the status quo. Policies must be implemented to encourage innovation and a market shift toward ADFs by ensuring any generic medication that references a branded ADF demonstrates that it does not have abuse-deterrent properties inferior to the branded ADF product. Policies must also require federal prescription drug benefit plans to cover ADFs to ensure consumers have access to such medications. PMID:25922655

In Vitro and In Vivo Evaluation of Infestation Deterrents Against Lice.

PubMed

Yoon, Kyong Sup; Ketzis, Jennifer K; Andrewes, Samuel W; Wu, Christopher S; Honraet, Kris; Staljanssens, Dorien; Rossel, Bart; Marshall Clark, J

2015-09-01

The human head louse is a cosmopolitan ectoparasite and frequently infests many people, particularly school-age children. Due to widespread pyrethroid resistance and the lack of efficient resistance management, there has been a considerable interest in the protection of uninfested people and prevention of reinfestation by disrupting lice transfer. In this study, two nonclinical model systems (in vitro and in vivo) were used to determine the efficacy of the infestation deterrents, Elimax lotion and Elimax shampoo, against human head lice or poultry chewing lice, respectively. With in vitro assessments, female head lice exhibited significantly higher avoidance responses to hair tufts treated with either of the test formulations, which led to significantly higher ovipositional avoidance when compared with female lice on control hair tufts. Additionally, both formulations were determined to be competent infestation deterrents in a competitive avoidance test in the presence of a known attractant (head louse feces extract). In in vivo assessments using a previously validated poultry model, Elimax shampoo was determined to be an efficacious deterrent against poultry chewing lice within Menopon spp. and Menacanthus spp. © The Authors 2015. Published by Oxford University Press on behalf of Entomological Society of America.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beck, James B.

Welcome to the February newsletter. Recent highlights include progress on the nuclear deal with Iran, the continued challenges with North Korea, the developing situation in Ukraine and Georgia, and issues related to the Unites States Nuclear Deterrent. In this newsletter, some key messages from the recent Nuclear Deterrent summit, which is annually held in Washington, DC, asre also included. The NSO recently hosted a workshop organized with the Center for International Security and Cooperation (CISAC) at Stanford University on how other States view nuclear weapons and deterrence. Participants included Dr. Bradley Roberts, Gen. (Ret.) Robert Kehler, Bridge Colby, Dr. Robertmore » Gromoll, and other experts. If you would like to have a more in-depth discussion on this or any related topics, please contact Sylvia Martinez at 667-6120 to set up some time.« less

Acoustic deterrence of bighead carp (Hypophthalmichthys nobilis) to a broadband sound stimulus

USGS Publications Warehouse

Vetter, Brooke J.; Murchy, Kelsie; Cupp, Aaron R.; Amberg, Jon J.; Gaikowski, Mark P.; Mensinger, Allen F.

2017-01-01

Recent studies have shown the potential of acoustic deterrents against invasive silver carp (Hypophthalmichthys molitrix). This study examined the phonotaxic response of the bighead carp (H. nobilis) to pure tones (500–2000 Hz) and playbacks of broadband sound from an underwater recording of a 100 hp outboard motor (0.06–10 kHz) in an outdoor concrete pond (10 × 5 × 1.2 m) at the U.S. Geological Survey Upper Midwest Environmental Science Center in La Crosse, WI. The number of consecutive times the fish reacted to sound from alternating locations at each end of the pond was assessed. Bighead carp were relatively indifferent to the pure tones with median consecutive responses ranging from 0 to 2 reactions away from the sound source. However, fish consistently exhibited significantly (P < 0.001) greater negative phonotaxis to the broadband sound (outboard motor recording) with an overall median response of 20 consecutive reactions during the 10 min trials. In over 50% of broadband sound tests, carp were still reacting to the stimulus at the end of the trial, implying that fish were not habituating to the sound. This study suggests that broadband sound may be an effective deterrent to bighead carp and provides a basis for conducting studies with wild fish.

Formulation Optimization of Hot Melt Extruded Abuse Deterrent Pellet Dosage Form Utilizing Design of Experiments (DOE)

PubMed Central

Maddineni, Sindhuri; Battu, Sunil Kumar; Morott, Joe; Majumdar, Soumyajit; Repka, Michael A.

2014-01-01

The objective of the present study was to develop techniques for an abuse-deterrent (AD) platform utilizing hot melt extrusion (HME) process. Formulation optimization was accomplished by utilizing Box-Behnken design of experiments to determine the effect of the three formulation factors: PolyOx™ WSR301, Benecel™ K15M, and Carbopol 71G; each of which was studied at three levels on TR attributes of the produced melt extruded pellets. A response surface methodology was utilized to identify the optimized formulation. Lidocaine Hydrochloride was used as a model drug, and suitable formulation ingredients were employed as carrier matrices and processing aids. All of the formulations were evaluated for the TR attributes such as particle size post-milling, gelling, percentage of drug extraction in water and alcohol. All of the DOE formulations demonstrated sufficient hardness and elasticity, and could not be reduced into fine particles (<150µm), which is a desirable feature to prevent snorting. In addition, all of the formulations exhibited good gelling tendency in water with minimal extraction of drug in the aqueous medium. Moreover, Benecel™ K15M in combination with PolyOx™ WSR301 could be utilized to produce pellets with TR potential. HME has been demonstrated to be a viable technique with a potential to develop novel abuse-deterrent formulations. PMID:24433429

Nuclear Deterrence. Applications of Elementary Probability to International Relations. Modules and Monographs in Undergraduate Mathematics and Its Applications Project. UMAP Unit 327.

ERIC Educational Resources Information Center

Smith, Harvey A.

This module is designed to apply mathematical models to nuclear deterrent problems, and to aid users in developing enlightened skepticism about the use of linear models in stability analyses and long-term predictions. An attempt is made at avoiding overwhelming complexities through concentration on land-based missile forces. It is noted that after…

Conflict with China: Prospects, Consequences, and Strategies for Deterrence

DTIC Science & Technology

2011-01-01

Burma / Myanmar . Above and beyond the dangers posed by a clash between the world’s two most populous countries, the presence of nuclear weapons on...Reconnaissance CBRNE Chemical, Biological, Radiological, Nuclear , High-Yield Explosives DMZ Demilitarized Zone DPRK Democratic People’s Republic of Korea EEZ...most concern to the United States. 2 Conflict with China: Prospects, Consequences, and Strategies for Deterrence Occasions for Conflict North Korea

Airman Scholar Journal. Volume 19, Spring 2013

DTIC Science & Technology

2013-01-01

of technological prowess and a symbol of ideological victory over communism . The Apollo program, which Stephen Johnson has called the United States...CO,80840 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) 11 ...Space Deterrence in a Labrynthine World Zachary Crippen and Andrew Hilton Topical Focus: Proliferation and Deterrence 11 Racism: A Stumbling Block to

Cyberdeterrence and Cyberwar

DTIC Science & Technology

2009-01-01

introduce subtle but vehicle-damaging changes to the chemical mix in the gasoline. Battle damage prediction is critical in establishing deterrence at all...the emotional resonance of the sort engen - dered by bloody terrorist attacks. If the target system is private (which it would practically have to be...secondary deterrence are the successful dissuasion of Nazi Germany and, half a century later, Saddam’s Iraq from using chemical weapons. Strategic

Nuclear Deterrence in Cyber-ia: Challenges and Controversies

DTIC Science & Technology

2016-09-01

acceptance of possible opponents. In short, the task of managing a nuclear crisis demands clear thinking and good information. But the employment of...economy, and social infrastructure. (Stuxnet was an exceptional, purpose-built destroyer of targeted nuclear facilities.) Failure of deterrence can...lead to historically unprecedented and socially catastrophic damage even in the case of a “limited” nuclear war by Cold War standards. 58 | Air

Deterrence in Cyberspace

DTIC Science & Technology

2012-06-13

sea craft, and affect food or water supplies are strategic and the target of a policy statement on cyber deterrence. Cyber-isolation The third...mechanical damage, but the uranium that was enriched was done so incorrectly and was contaminated to a point it would have to be re-processed.8...Insurgency, and Peacekeeping, (New York: Stackpole, 1971). 38 in Malaysia , or at least it provides a readily available conduit to communication

Biting deterrence and insecticidal activity of hydrazide–hydrazones and their corresponding 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazoles against Aedes aegypti

USDA-ARS?s Scientific Manuscript database

BACKGROUND: Hydrazones are important compounds for drug design and they have also good insecticidal activity. In this study, A series of hydrazide–hydrazones (1-10) and 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazoles (11-20) were investigated for their biting deterrent and insecticidal act...

Strategic Studies Quarterly. Volume 5, Number 4, Winter 2011

DTIC Science & Technology

2011-12-01

attack, and its destructive capacity intrinsically poses existential threats to nation- states (not to mention their populations). This is not true...nuclear technology. Unlike nuclear, cyber does not pose an existential threat. As Martin Libicki points out, destruction or disconnection of cyber...the Cuban missile crisis, existential deterrence worked, and a few Soviet bombs created deterrence despite an over- whelming American superiority in

NATOs Deterrence Strategy is Failing. The Enhanced Forward Presence: Delusion or Renewal

DTIC Science & Technology

2018-04-20

can credibly deter Russia. NATO, Enhanced Forward Presence, Deterrence, Multi -Domain Battle, Russia, Baltics Unclassified Unclassified Unclassified...Strategy. The contents of this paper reflect my own personal views and are not necessarily endorsed by the Joint Forces Staff College or the Department... multi -domain capabilities . . . [and] control information,”5 but in response, NATO has struggled to convincingly adjust to this changing character

The nuclear arms debate: Ethical and political implications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johansen, R.C.

1984-01-01

This book contains the following seven papers: Moral Aspects of the Nuclear Arms Debate: The Contribution of the U.S. Catholic Bishops; The Strategic and Arms Control Implications of the Bishop's Pastoral Letter; Applying Just-War Doctrine to Nuclear Deterrence; Nuclearism in Western Culture; Mutal Assured Destruction: A Stable Nuclear Deterrent; The Prospect for a Freeze on Nuclear Weapons; and The Soviet Union and Arms Control.

Acaricidal and oviposition deterring effects of santalol identified in sandalwood oil against two-spotted spider mite, Tetranychus urticae Koch (Acari: Tetranychidae).

PubMed

Roh, Hyun Sik; Lim, Eu Gene; Kim, Jinwoo; Park, Chung Gyoo

2011-12-01

Thirty-four plant essential oils were screened for their acaricidal and oviposition deterrent activities against two-spotted spider mite (TSSM), Tetranychus urticae Koch (Acari: Tetranychidae), in the laboratory using a leaf-dip bioassay. From initial trials, sandalwood and common thyme oils were observed to be the most effective against TSSM adult females. Subsequent trials confirmed that only sandalwood oil was significantly active (87.2 ± 2.9% mortality) against TSSM adult females. Sandalwood oil also demonstrated oviposition deterring effects based on a 89.3% reduction of the total number of eggs on leaf disks treated with the oil. GC-MS analysis revealed that the main components of the sandalwood oil were α-santalol (45.8%), β-santalol (20.6%), β-sinensal (9.4%), and epi-β-santalol (3.3%). A mixture of α- and β-santalol (51.0:22.9, respectively) produced significantly higher mortality (85.5 ± 2.9%) and oviposition deterrent effects (94.7% reduction in the number of eggs) than the control. Phytotoxicity was not shown on rose shoots to which a 0.1% solution of sandalwood oil was applied.

Structural and chemical insect defenses in calcium oxalate defective mutants of Medicago truncatula

USDA-ARS?s Scientific Manuscript database

Plant structures can act as defense against herbivorous insects, causing them to avoid feeding on a given plant or tissue. Mineral crystals of calcium oxalate in leaves of Medicago truncatula Gaertn. are effective deterrents of lepidopteran feeding, and they inhibit conversion of leaves into insect ...

Conceptions of politics, morality, and war in the nuclear policy debates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ware, L.C.

1993-01-01

During the resurgent nuclear debates from the mid-1970s to the mid-1980s, analysts sharply disagreed about the appropriate means and ends of strategy. Deterrence dominance strategists argued that America required a countervailing capacity to sustain a viable deterrent posture and to contain Soviet adventurism. Proponents of pure deterrence claimed that the risks endemic to mutual vulnerability would suffice to moderate the superpower rivalry. Advocates of denuclearization charged that reliance on nuclear weaponry posed the greatest danger to human well-being and called for diplomatic measures to establish a disarmament regime. While scholars have systemically explored the strategic and technological components of themore » controversy, few studies have examined the political theoretic dimensions. Through a textual exegesis of the writings of key participants, this work seeks to demonstrate that contending conceptions of politics and morality inform dissension about the viability of coercive power in the nuclear age. Justifications of deterrence dominance proposals generally conflate political and ethical considerations through variants of Hobbesian skepticism or liberal just war interventionism. Such arguments perceive the state as the locus of societal values and sovereignty as sanctioning extensive activities in the global system. Pure deterrence notions posit an irreconcilable tension between politics and morality that corresponds with a tragic vision: war may be a necessary element of sociality, but it seldom has truly creative consequences. From this perspective, the state is a morally ambiguous agent that can preserve and endanger societal well-being. Finally, associated with the denuclearization school is a conviction that progressive social movements can conform politics to essential ethical precepts by minimizing the role of coercive power. In this view, the state and its claim to sovereignty are primary sources of the war system, hence must be radically altered.« less

Off the street and into “the cut”: Deterrence and displacement in NYC's quality of life marijuana policing

PubMed Central

Elliott, Luther; Golub, Andrew; Dunlap, Eloise

2011-01-01

This paper examines the accounts of NYC marijuana smokers about the information and values underlying decisions about where to smoke. We do so to assess the deterrent value of NYC's “quality of life” policing of marijuana in public view. Participants indicated a general awareness of escalated marijuana policing and its attendant risks and almost universally spoke of avoiding public use in high-traffic locations and in the city's cultural and commercial centres. Beyond that, however, the deterrent value of aggressive marijuana policing appears limited. Individuals without access to private space reported outdoor marijuana use as a normalized peer group activity that has increasingly been displaced to marginal and interstitial public spaces that were collectively referred to by participants as “the cut.” PMID:22001856

A Game Theoretic Model of Thermonuclear Cyberwar

DOE Office of Scientific and Technical Information (OSTI.GOV)

Soper, Braden C.

In this paper we propose a formal game theoretic model of thermonuclear cyberwar based on ideas found in [1] and [2]. Our intention is that such a game will act as a first step toward building more complete formal models of Cross-Domain Deterrence (CDD). We believe the proposed thermonuclear cyberwar game is an ideal place to start on such an endeavor because the game can be fashioned in a way that is closely related to the classical models of nuclear deterrence [4–6], but with obvious modifications that will help to elucidate the complexities introduced by a second domain. We startmore » with the classical bimatrix nuclear deterrence game based on the game of chicken, but introduce uncertainty via a left-of-launch cyber capability that one or both players may possess.« less

The Complexity of Threats to Nuclear Strategic Deterrence Posture

DTIC Science & Technology

2017-02-07

environment, a status quo but things are improving, a status quo but things are getting worse, and the occurrence of a game -changing event. Findings...adversaries. This information will certainly inform this research, as game changing technology will in due course affect the strategic nuclear deterrence...Congressional Research Service, RAND Corporation, and certain peer-reviewed and scholarly articles. The fourth independent variable, “Occurrence of a Game

Taking a Quantum Leap in Cyber Deterrence

DTIC Science & Technology

2010-02-17

calculus that weighs the cost and benefit of an action. 76 According to John Mearsheimer, that decision calculus is ―a function of the costs and...frame an adversary‘s rationale and decision calculus . 82 Understanding a group‘s rationale helps frame a strategy for deterrence. Emanuel Adler...only remaining option. Mearsheimer‘s decision calculus described above indicates that if the cost of an attack is high, or the probability of

Conflict Containment in the Balkans: Testing Extended Deterrence.

DTIC Science & Technology

1995-03-01

STATEMENT 12b. DISTRIBUTION CODE Approved for public release; distribution is unlimited. 13. ABSTRACT This thesis critically analyzes a prominent theoretical...Containment 15. NUMBER OF in the Balkans; Deterrence; Coercive Diplomacy; Balance of Forces. PAGES: 161 16. PRICE CODE 17. SECURITY CLASSIFI- 18. SECURITY...Department of National Security Affai sAccesion For NTIS CRA&I DTtC TAB Unannounced Justifca ........... By- Distribution Availability Codes Avail and/or Dist

Perseverance of Power: The Relevancy of Nuclear Deterrence in the Future

DTIC Science & Technology

2013-06-01

22 James Wood Jr. Forsyth, B. Chance Saltzman , and Gary Jr. Schaub, "Rememberance of Things Past," Strategic Studies Quarterly (Spring 2010): 75...Deterrence Now: 152. 117 Reagan, "Nuclear Weapons Employment Policy". 118 Forsyth, Saltzman , and Schaub, "Rememberance of Things Past," 75. 119 See notes 96...international order. 122 Forsyth, Saltzman , and Schaub, "Rememberance of Things Past," 80

Signaling the End of Deterrence Afforded by Dual Capable Aircraft

DTIC Science & Technology

2017-04-06

INTRODUCTION For more than 60 years, the Unites States and Europe relied on fighter aircraft capable of executing conventional and nuclear strike...missions. Known as dual-capable aircraft (DCA), these fighters were an integral part of the US extended nuclear deterrence strategy in Asia and Europe...force structure, sustainment and modernization by the US and Allied nations allowed tactical nuclear forces to atrophy. Starting in 2010, the US and

Challenging Minimum Deterrence: Articulating the Contemporary Relevance of Nuclear Weapons

DTIC Science & Technology

2016-07-13

Command and Control: Nuclear Weapons, the Damascus Accident , and the Illusion of Safety (New York: Penguin Press, 2013), 484. 36. Keir A. Lieber and...Remembrance of Things Past,” 78. 53. Scott D. Sagan, The Limits of Safety: Organizations, Accidents , and Nuclear Weapons (Princeton, NJ: Princeton...16 | Air & Space Power Journal Challenging Minimum Deterrence Articulating the Contemporary Relevance of Nuclear Weapons Maj Joshua D. Wiitala, USAF

Cyber Attacks, Attribution, and Deterrence: Three Case Studies

DTIC Science & Technology

2015-05-23

threat informs his decision about the appropriate deterrent counter-threats. There tend to be three camps in general: Minimalists , Moderates, and...Alarmists. Minimalists do not require much explanation because they are the authors who believe that cyber does not pose any significant threat...Armageddon.”32 Amongst the minimalists are Lawrence Freedman and Thomas Rid. Freedman grants discussion of cyber attacks a scant two pages in his seven

Out of (South) Africa: Pretoria`s nuclear weapons experience. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Horton, R.E.

1998-04-01

The primary focus of this paper is the impact of key South African leaders on the successful developments and subsequent rollbacks of South Africa`s nuclear weapons capability. It highlights the key milestones in the development of South Africa`s nuclear weapon capability. It also relates how different groups within South Africa (scientists, politicians, military and technocrats) interacted to successfully produce South Africa`s nuclear deterrent. It emphasizes the pivotal influence of the senior political leadership to pursue nuclear rollback given the disadvantages of its nuclear means to achieve vital national interests. The conclusions drawn from flu`s effort are the South African nuclearmore » program was an extreme response to its own identity Crisis. Nuclear weapons became a means to achieving a long term end of a closer affiliation with the West. A South Africa yearning to be identified as a Western nation and receive guarantees of its security rationalized the need for a nuclear deterrent. The deterrent was intended to draw in Western support to counter a feared total onslaught by Communist forces in the region. Two decades later, that same South Africa relinquished its nuclear deterrent and reformed its domestic policies to secure improved economic and political integration with the West.« less

The Nuclear Posture Review (NPR) : are we safer?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brune, Nancy E.

2010-07-01

Nuclear Posture Review (NPR) is designed to make world safer by reducing the role of U.S. nuclear weapons and reducing the salience of nuclear weapons. U.S. also seeks to maintain a credible nuclear deterrent and reinforce regional security architectures with missile defenses and other conventional military capabilities. But recent studies suggest that nuclear proliferation is a direct response to the perceived threat of U.S. conventional capabilities not U.S. nuclear stockpile. If this is true, then the intent of the NPR to reduce the role and numbers of nuclear weapons and strengthen conventional military capabilities may actually make the world lessmore » safe. First stated objective of NPR is to reduce the role and numbers of U.S. nuclear weapons, reduce the salience of nuclear weapons and move step by step toward eliminating them. Second stated objective is a reaffirmation of U.S. commitment to maintaining a strong deterrent which forms the basis of U.S. assurances to allies and partners. The pathway - made explicit throughout the NPR - for reducing the role and numbers of nuclear weapons while maintaining a credible nuclear deterrent and reinforcing regional security architectures is to give conventional forces and capabilities and missile defenses (e.g. non-nuclear elements) a greater share of the deterrence burden.« less

Laboratory-based testing to evaluate abuse-deterrent formulations and satisfy the Food and Drug Administration's recommendation for Category 1 Testing.

PubMed

Altomare, Christopher; Kinzler, Eric R; Buchhalter, August R; Cone, Edward J; Costantino, Anthony

The US Food and Drug Administration (FDA) considers the development of abuse-deterrent formulations of solid oral dosage forms a public health priority and has outlined a series of premarket studies that should be performed prior to submitting an application to the Agency. Category 1 studies are performed to characterize whether the abuse-deterrent properties of a new formulation can be easily defeated. Study protocols are designed to evaluate common abuse patterns of prescription medications as well as more advanced methods that have been reported on drug abuse websites and forums. Because FDA believes Category 1 testing should fully characterize the abuse-deterrent characteristics of an investigational formulation, Category 1 testing is time consuming and requires specialized laboratory resources as well as advanced knowledge of prescription medication abuse. Recent Advisory Committee meetings at FDA have shown that Category 1 tests play a critical role in FDA's evaluation of an investigational formulation. In this article, we will provide a general overview of the methods of manipulation and routes of administration commonly utilized by prescription drug abusers, how those methods and routes are evaluated in a laboratory setting, and discuss data intake, analysis, and reporting to satisfy FDA's Category 1 testing requirements.

Methyl Jasmonate-Induced Monoterpenes in Scots Pine and Norway Spruce Tissues Affect Pine Weevil Orientation.

PubMed

Lundborg, Lina; Nordlander, Göran; Björklund, Niklas; Nordenhem, Henrik; Borg-Karlson, Anna-Karin

2016-12-01

In large parts of Europe, insecticide-free measures for protecting conifer plants are desired to suppress damage by the pine weevil Hylobius abietis (L.). Treatment with methyl jasmonate (MeJA), a chemical elicitor already used in crop production, may enhance expression of chemical defenses in seedlings in conifer regenerations. However, in a previous experiment, MeJA treatment resulted in substantially better field protection for Scots pine (Pinus sylvestris L.) than for Norway spruce (Picea abies (L.) Karst.). Hypothesizing that the variations may be at least due partly to volatiles released by MeJA-treated seedlings and their effects on pine weevil orientation, we examined tissue extracts of seedlings (from the same batches as previously used) by two-dimensional GC-MS. We found that the MeJA treatment increased contents of the monoterpene (-)-β-pinene in phloem (the weevil's main target tissue) of both tree species, however, the (-)-β-pinene/(-)-α-pinene ratio increased more in the phloem of P. sylvestris. We also tested the attractiveness of individual monoterpenes found in conifer tissues (needles and phloem) for pine weevils using an arena with traps baited with single-substance dispensers and pine twigs. Trap catches were reduced when the pine material was combined with a dispenser releasing (-)-β-pinene, (+)-3-carene, (-)-bornyl acetate or 1,8-cineole. However, (-)-α-pinene did not have this effect. Thus, the greater field protection of MeJA-treated P. sylvestris seedlings may be due to the selective induction of increases in contents of the deterrent (-)-β-pinene, in contrast to strong increases in both non-deterrent (-)-α-pinene and the deterrent (-)-β-pinene in P. abies seedlings.

Response to Intervention (RTI): A Mixed Methods Study Evaluating the Effects of Behavior Training Software on Behavior of In-School Suspension Students

ERIC Educational Resources Information Center

Cooper, Rosie Nicole

2014-01-01

Excessive classroom disruption is prevalent among today's public high schools and is a deterrent to the academic and social achievements of students. Using Response to Intervention (RtI) to equip in-school suspension (ISS) programs with a research-based behavioral curriculum is one possible solution to efficiently and cost-effectively remediating…

Medicago truncatula-derived calcium oxalate crystals have a negative impact on chewing insect performance via their physical properties

USDA-ARS?s Scientific Manuscript database

Plant structural traits often act as defenses against herbivorous insects, causing them to avoid feeding on a given plant or tissue. Mineral crystals of calcium oxalate in Medicago truncatula Gaertn. (Fabaceae) leaves have previously been shown to be effective deterrents of lepidopteran insect feedi...

The Use of Electronic Book Theft Detection Systems in Libraries.

ERIC Educational Resources Information Center

Witt, Thomas B.

1996-01-01

Although electronic book theft detection systems can be a deterrent to library material theft, no electronic system is foolproof, and a total security program is necessary to ensure collection security. Describes how book theft detection systems work, their effectiveness, and the problems inherent in technology. A total security program considers…

Thinking About Preventing Nuclear War.

ERIC Educational Resources Information Center

Ground Zero, Washington, DC.

Potential paths to nuclear war and the available means of prevention of nuclear war are discussed. Presented is a detailed description of six nuclear war scenarios, and brief examples of types of potential deterrents to nuclear war (firebreaks) which are relevant for each. To be effective, the right combination of firebreaks must be used, the…

The Quest for Antifeedants for the Spruce Budworm (Choristoneura fumiferana (Clem.)

Treesearch

M.D. Bentley; D.E. Leonard; G.M.  Strunz

1983-01-01

Extracts of non-host plants and selected naturally occurring compounds have been screened for their effects on feeding by spruce budworm larvae, (Choristoneura fumiferana (Clem.), using as diet a filter paper substrate impregnated with the synergistic feeding stimulants, sucrose, and L-proline. The most potent feeding deterrents identified to date...

Alternatives to Violence: Empowering Youth To Develop Healthy Relationships.

ERIC Educational Resources Information Center

Wolfe, David A.; And Others

Practical ways are presented to promote healthy and nonviolent relationships for youth, guided by the belief that prevention is cheaper and more effective than deterrence or punishment. Equality and balance are the basis of prevention efforts. It must be acknowledged that violence is ingrained in cultural expressions of power and inequality, and…

Both Suspension and Alternatives Work, Depending on One's Aim

ERIC Educational Resources Information Center

Bear, George G.

2012-01-01

In this commentary on the special series, I argue that whereas a zero-tolerance approach to school discipline is "something stupid" (Kauffman & Brigham, 2000) the use of suspension might not be. Despite its limitations, suspension and other forms of punishment serve as effective deterrents of behavior problems for most children, especially when…

Community Differences in the Association between Parenting: Practices and Child Conduct Problems.

ERIC Educational Resources Information Center

Simons, Ronald L.; Lin, Kuei-Hsiu; Gordon, Leslie C.; Brody, Gene H.; Murry, Velma; Conger, Rand D.

2002-01-01

Surveys African American families (N=841) to test hypothesis that community context might influence the association between parent control and punishment on child conduct problems. Survey found the deterrent effect of caretaker control on conduct problems became smaller as deviant behavior became more widespread. Results suggest that a particular…

Boom or Bust: Britain’s Nuclear Deterrent Beyond 2025

DTIC Science & Technology

2012-04-26

Labour government of the day, spelt out a commitment to replace Britain’s Submarine Launched Ballistic Missile (SLBM) nuclear deterrent with a similar...global and national economies; banks collapsed, markets went into turmoil and the extent of government debts and borrowing was laid bare. The fiscal...disarmament. In 2010 Nick Clegg stated that: "Neither Labour nor the Conservatives are prepared to question spending tens of billions of pounds on a like

From War to Deterrence? Israel-Hezbollah Conflict Since 2006

DTIC Science & Technology

2014-05-01

Israeli Air Force (IAF) strike on a Syrian reactor in September 2007, the issue of the Lebanese front, although unsettled, was moved to the...widespread con- fusion over the exact level of readiness and coverage of its missile defense architecture. Given the current passion of Israeli...Variations on a Theme: The Conceptual - ization of Deterrence in Israeli Strategic Thinking,” Security Stud- ies, Vol. 7, No. 3, Spring 1998, pp. 145-181

Can Counter-Gang Models be Applied to Counter ISIS’s Internet Recruitment Campaign

DTIC Science & Technology

2016-06-10

limitation that exists is the lack of reliable statistics from social media companies in regards to the quantity of ISIS-affiliated sites, which exist on... statistics , they have approximately 320-million monthly active users with thirty-five-plus languages supported and 77 percent of accounts located...Justice and Delinquency Prevention program. For deterrence-based models, the primary point of research is focused deterrence models with emphasis placed

Extended Deterrence: Taking Stock of Current Policy and Updating the Research and PME Agendas

DTIC Science & Technology

2014-08-01

Conference and Venue The INSS “Extended Deterrence: Taking Stock of Current policy and Updating the Research and PME Agendas” workshop took place...Force Institute for National Security Studies ( INSS ) which is sponsored by the Air Force Strategic Plans and Policy Division (A5XP). Subject...emerging strategic environment? INSS anticipated that the discussion would be influenced by current developments such as: • The Russian incursion

Realities of Deterrence and Retaliatory Options to Attacks in Space and Cyberspace

DTIC Science & Technology

2012-02-15

instruments of power. It is an evolving landscape of electronic and kinetic threats that may merely scratch the surface of what might be at an...communications satellite; and in 2008, during two separate attacks, hackers accessed National Aeronautics and Space Administration ( NASA ) telemetry...unacceptable and to be avoided.23,24 Deterrence between the United States and the Soviet Union was bi-polar, between known adversaries. This is not

Abuse-deterrent formulations of prescription opioid analgesics in the management of chronic noncancer pain.

PubMed

Hale, Martin E; Moe, Derek; Bond, Mary; Gasior, Maciej; Malamut, Richard

2016-10-01

Misuse, abuse and diversion of prescription opioid analgesics represent a global public health concern. The development of abuse-deterrent formulations (ADFs) of prescription opioid analgesics is an important step toward reducing abuse and diversion of these medications, as well as potentially limiting medical consequences when misused or administered in error. ADFs aim to hinder extraction of the active ingredient, prevent administration through alternative routes and/or make abuse of the manipulated product less attractive, less rewarding or aversive. However, opioid ADFs may still be abused via the intended route of administration by increasing the dose and/or dosing frequency. The science of abuse deterrence and the regulatory landscape are still relatively new and evolving. This paper reviews the current status of opioid ADFs, with particular focus on different approaches that can be used to deter abuse, regulatory considerations and implications for clinical management.

National military strategy in the post cold war era: Nuclear deterrence or an alternative. Study project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pooley, G.R.

In the aftermath of the Cold War it becomes necessary to explore the validity of nuclear deterrence as the cornerstone of the United States National Military Strategy for the upcoming period of transition in international relations. Using the current world situation as a starting point, the evolving trends in international relations, arms control and nuclear proliferation, the strategic threat and the evolution of technology will be analyzed in an effort to forecast the complexion of international relations twenty years hence. Then, within this context, nuclear deterrence and a non nuclear alternative nonoffensive defense, proposed by the Danish political scientist, Bjornmore » Moller, will be examined. In the final analysis, this project will suggest an appropriate direction for the evolution of the United States' National Military Strategy which, in the opinion of the author, provides the best probability for long term world peace.« less

In defiance of nuclear deterrence: anti-nuclear New Zealand after two decades.

PubMed

Reitzig, Andreas

2006-01-01

In 1984, nuclear-armed and nuclear-powered vessels were banned from New Zealand to express the country's rejection of the nuclear deterrence concept. This led to a disagreement with the United States. Today, the ban on nuclear-powered ships is the only element of the nuclear-free legislation that still strains US-New Zealand relations. This article presents the reasons for the ban on nuclear-powered ships, which include scientific safety concerns, a symbolic rejection of the nuclear deterrence posture, and patriotic factors such as a nuclear-free national identity. The military and economic consequences of the ban are also examined. Since the ban on nuclear-powered vessels appears to be neither widely known abroad nor commonly recognised as a supportive disarmament measure outside New Zealand, it is concluded that whatever the future of this ban will be, New Zealand's anti-nuclear image will remain known internationally through the ban on nuclear arms.

Nonoffensive defense is overrated

DOE Office of Scientific and Technical Information (OSTI.GOV)

Flanagan, S.J.

1988-09-01

Some Western analysts argue that European security would stabilize if nations shifted to forces and doctrines that left them structurally incapable of conducting offensive military actions. Some, including American scholar Gene Sharp, have even called for replacing traditional military forces with plans for civilian-based resistance. Purely defensive postures would be reassuring to neighboring states, all of these theorists say, but such defenses would still be strong enough to defeat an attack if deterrence failed. This defensive-only stance, according to its advocates, is a purer form of deterrence by denial than now exists, since it removes even the possibility of inflictingmore » punishment in retaliation for an attack: it deters only be denying victory. But Mr. Flanagan questions whether such defense actually would serve as a credible deterrent. In addition, the various proposed schemes share some serious weaknesses, which he proceeds to discuss. 5 refs.« less

The impact of state laws protecting abortion clinics and reproductive rights on crimes against abortion providers: deterrence, backlash, or neither?

PubMed

Pridemore, William Alex; Freilich, Joshua D

2007-12-01

Since Roe v. Wade, most states have passed laws either restricting or further protecting reproductive rights. During a wave of anti-abortion violence in the early 1990s, several states also enacted legislation protecting abortion clinics, staff, and patients. One hypothesis drawn from the theoretical literature predicts that these laws provide a deterrent effect and thus fewer anti-abortion crimes in states that protect clinics and reproductive rights. An alternative hypothesis drawn from the literature expects a backlash effect from radical members of the movement and thus more crimes in states with protective legislation. We tested these competing hypotheses by taking advantage of unique data sets that gauge the strength of laws protecting clinics and reproductive rights and that provide self-report victimization data from clinics. Employing logistic regression and controlling for several potential covariates, we found null effects and thus no support for either hypothesis. The null findings were consistent across a number of different types of victimization. Our discussion contextualizes these results in terms of previous research on crimes against abortion providers, discusses alternative explanations for the null findings, and considers the implications for future policy development and research.

Nectar microbes can reduce secondary metabolites in nectar and alter effects on nectar consumption by pollinators.

PubMed

Vannette, Rachel L; Fukami, Tadashi

2016-06-01

Secondary metabolites that are present in floral nectar have been hypothesized to enhance specificity in plant-pollinator mutualism by reducing larceny by non-pollinators, including microorganisms that colonize nectar. However, few studies have tested this hypothesis. Using synthetic nectar, we conducted laboratory and field experiments to examine the effects of five chemical compounds found in nectar on the growth and metabolism of nectar-colonizing yeasts and bacteria, and the interactive effects of these compounds and nectar microbes on the consumption of nectar by pollinators. In most cases, focal compounds inhibited microbial growth, but the extent of these effects depended on compound identity, concentration, and microbial species. Moreover, most compounds did not substantially decrease sugar metabolism by microbes, and microbes reduced the concentration of some compounds in nectar. Using artificial flowers in the field, we also found that the common nectar yeast Metschnikowia reukaufii altered nectar consumption by small floral visitors, but only in nectar containing catalpol. This effect was likely mediated by a mechanism independent of catalpol metabolism. Despite strong compound-specific effects on microbial growth, our results suggest that the secondary metabolites tested here are unlikely to be an effective general defense mechanism for preserving nectar sugars for pollinators. Instead, our results indicate that microbial colonization of nectar could reduce the concentration of secondary compounds in nectar and, in some cases, reduce deterrence to pollinators.

Advances in chemical and physical properties of electric arc furnace carbon steel slag by hot stage processing and mineral mixing.

PubMed

Liapis, Ioannis; Papayianni, Ioanna

2015-01-01

Slags are recognised as a highly efficient, cost effective tool in the metal processing industry, by minimising heat losses, reducing metal oxidation through contact with air, removing metal impurities and protecting refractories and graphite electrodes. When compared to natural aggregates for use in the construction industry, slags have higher specific weight that acts as an economic deterrent. A method of altering the specific weight of EAFC slag by hot stage processing and mineral mixing, during steel production is presented in this article. The method has minimal interference with the production process of steel, even by limited additions of appropriate minerals at high temperatures. Five minerals are examined, namely perlite, ladle furnace slag, bauxite, diatomite and olivine. Measurements of specific weight are accompanied by X-ray diffraction (XRD) and fluorescence (XRF) analysis and scanning electron microscopy spectral images. It is also shown how altering the chemical composition is expected to affect the furnace refractory lining. Additionally, the process has been repeated for the most suitable mix in gas furnace and physical properties (FI, SI, LA, PSV, AAV, volume stability) examined. Alteration of the specific weight can result in tailoring slag properties for specific applications in the construction sector. Copyright © 2014 Elsevier B.V. All rights reserved.

Bed bug deterrence

PubMed Central

2010-01-01

A recent study in BMC Biology has determined that the immature stage of the bed bug (the nymph) signals its reproductive status to adult males using pheromones and thus avoids the trauma associated with copulation in this species. The success of this nymphal strategy of deterrence is instructive. Against the background of increasing problems with bed bugs, this research raises the question whether pheromones might be used to control them. See research article http://www.biomedcentral.com/1741-7007/8/121 PMID:20828375

Tacit Knowledge Involvement in the Production of Nuclear Weapons: A Critical Component of a Credible US Nuclear Deterrent in the 21st Century

DTIC Science & Technology

2013-02-14

important in sustaining a credible nuclear deterrent without testing. Thinking in the early days of the Manhattan Project was that designing a nuclear...weapon would occur quickly. Renowned physicist Edward Teller recalled being discouraged from joining the Manhattan Project at Los Alamos National...difficulties with their nuclear program in the early years despite involvement with portions of the Manhattan Project . With permission, the British

Donating blood: a meta-analytic review of self-reported motivators and deterrents.

PubMed

Bednall, Timothy C; Bove, Liliana L

2011-10-01

Although research on blood donor motivation abounds, most studies have typically focused on small sets of variables, used different terminology to label equivalent constructs, and have not attempted to generalize findings beyond their individual settings. The current study sought to synthesize past findings into a unified taxonomy of blood donation drivers and deterrents and to estimate the prevalence of each factor across the worldwide population of donors and eligible nondonors. Primary studies were collected, and cross-validated categories of donation motivators and deterrents were developed. Proportions of first-time, repeat, lapsed, apheresis, and eligible nondonors endorsing each category were calculated. In terms of motivators, first-time and repeat donors most frequently cited convenience, prosocial motivation, and personal values; apheresis donors similarly cited the latter 2 motivators and money. Conversely, lapsed donors more often cited collection agency reputation, perceived need for donation, and marketing communication as motivators. In terms of deterrents, both donors and nondonors most frequently referred to low self-efficacy to donate, low involvement, inconvenience, absence of marketing communication, ineffective incentives, lack of knowledge about donating, negative service experiences, and fear. The integration of past findings has yielded a comprehensive taxonomy of factors influencing blood donation and has provided insight into the prevalence of each factor across multiple stages of donors' careers. Implications for collection agencies are discussed. Copyright © 2011 Elsevier Inc. All rights reserved.

Chemical Constituents of Supercritical Extracts from Alpinia officinarum and the Feeding Deterrent Activity against Tribolium castaneum.

PubMed

Xin, Mintong; Guo, Shanshan; Zhang, Wenjuan; Geng, Zhufeng; Liang, Junyu; Du, Shushan; Deng, Zhiwei; Wang, Yongyan

2017-04-18

Alpinia officinarum has been confirmed to possess bioactivities against some pests. In this work, a sample was obtained from A. officinarum rhizomes by supercritical fluid CO₂ extraction (SFE). According to GC-MS analysis, the main chemical components for SFE-sample included benzylacetone (26.77%), 1,7-diphenyl-5-hydroxy-3-heptanone (17.78%), guaiacylacetone (10.03%) and benzenepropanal (7.42%). The essential oil of A. officinarum rhizomes (LD 50 = 20.71 μg/adult) exhibited more contact toxicity than SFE extract (LD 50 = 82.72 μg/adult) against Tribolium castaneum . From SFE extracts, one new compound, 1-phenyl-4-(16,17-dimethyl-9,13-octadiene)-5-isopentenyl-7-(4"-methoxyl-3"-hydroxyl-phenyl)-3-heptanone ( 3 ), together with five known compounds identified as 5-hydroxy-1,7-diphenyl-3-heptanone ( 1 ), 1,7-diphenyl-4-hepten-3-one ( 2 ), galangin ( 4 ), galangin-3-methyl ether ( 5 ) and pinocembrin ( 6 ), were isolated and their feeding deterrent activities against T. castaneum adults were assessed. It was found that compounds 1 - 6 had feeding deterrent activities against T. castaneum with feeding deterrent indices of 18.21%, 18.94%, 19.79%, 26.99%, 20.34%, and 35.81%, respectively, at the concentration of 1500 ppm. Hence, the essential oil and SFE extracts/compounds of A. officinarum rhizomes represent promising alternatives in the control of T. castaneum adults.

Deterrence and Cyber-Weapons

DTIC Science & Technology

2013-03-01

range of options by which they can effectively increase their resolve on an issue without risking the commitment of large forces or mutually assured...Washington DC 20503. 1. AGENCY USE ONLY (Leave blank) 2. REPORT DATE March 2013 3. REPORT TYPE AND DATES COVERED Master’s Thesis 4. TITLE AND...conventional, nuclear, and RMA—and how they typically influence this behavior . After proposing selected factors that influence the effectiveness of a cyber

Discovery of a protective Rickettsia prowazekii antigen recognized by CD8+ T cells, RP884, using an in vivo screening platform.

PubMed

Gazi, Michal; Caro-Gomez, Erika; Goez, Yenny; Cespedes, Maria A; Hidalgo, Marylin; Correa, Paula; Valbuena, Gustavo

2013-01-01

Rickettsia prowazekii has been tested for biological warfare due to the high mortality that it produces after aerosol transmission of very low numbers of rickettsiae. Epidemic typhus, the infection caused by these obligately intracellular bacteria, continues to be a threat because it is difficult to diagnose due to initial non-specific symptoms and the lack of commercial diagnostic tests that are sensitive and specific during the initial clinical presentation. A vaccine to prevent epidemic typhus would constitute an effective deterrent to the weaponization of R. prowazekii; however, an effective and safe vaccine is not currently available. Due to the cytoplasmic niche of Rickettsia, CD8(+) T-cells are critical effectors of immunity; however, the identification of antigens recognized by these cells has not been systematically addressed. To help close this gap, we designed an antigen discovery strategy that uses cell-based vaccination with antigen presenting cells expressing microbe's proteins targeted to the MHC class I presentation pathway. We report the use of this method to discover a protective T-cell rickettsial antigen, RP884, among a test subset of rickettsial proteins.

Ronald Reagan's Re-formulation of the Rhetoric of War: Analysis of the "Zero Option,""Evil Empire," and "Star Wars" Addresses.

ERIC Educational Resources Information Center

Goodnight, G. Thomas

1986-01-01

Analyzes speeches in which Reagan challenges the following convention: science will continue to create technologically advanced weapons against which no effective defense will be developed, making deterrence through an assured retaliatory capability the only possible defense. Textual analysis reveals how public discourse can achieve unities of…

The Geography of Deterrence: Exploring the Small Area Effects of Sobriety Checkpoints on Alcohol-Impaired Collision Rates within a City

ERIC Educational Resources Information Center

Nunn, Samuel; Newby, William

2011-01-01

This article examines alcohol-impaired collision metrics around nine sobriety checkpoint locations in Indianapolis, Indiana, before and after implementation of 22 checkpoints, using a pre/post examination, a pre/post nonequivalent comparison group analysis, and an interrupted time series approach. Traffic safety officials used geographical…

The Fact of the Matter

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kippen, Karen Elizabeth; Montoya, Donald Raymond

For more than 20 years the science and engineering capabilities of the nation’s Stockpile Stewardship Program have allowed the United States to sustain a safe, secure, and effective nuclear deterrent. Most of the problems identifi ed within the nuclear stockpile are related to its aging materials. MaRIE will advance this record of excellence in addressing such materials problems.

InfoSec-MobCop - Framework for Theft Detection and Data Security on Mobile Computing Devices

NASA Astrophysics Data System (ADS)

Gupta, Anand; Gupta, Deepank; Gupta, Nidhi

People steal mobile devices with the intention of making money either by selling the mobile or by taking the sensitive information stored inside it. Mobile thefts are rising even with existing deterrents in place. This is because; they are ineffective, as they generate unnecessary alerts and might require expensive hardware equipments. In this paper a novel framework termed as InfoSec-MobCop is proposed which secures a mobile user’s data and discovers theft by detecting any anomaly in the user behavior. The anomaly of the user is computed by extracting and monitoring user specific details (typing pattern and usage history). The result of any intrusion attempt by a masquerader is intimated to the service provider through an SMS. Effectiveness of the used approach is discussed using FAR and FRR graphs. The experimental system uses both real users and simulated studies to quantify the effectiveness of the InfoSec-MobCop (Information Security Mobile Cop).

Dancing the Two-Step in Ontario's Long-term Care Sector: More Deterrence-oriented Regulation = Ownership and Management Consolidation.

PubMed

Daly, Tamara

2015-03-01

This paper explores shifts in public and private delivery over time through an analysis of Ontario's approach to LTC funding and regulation in relation to other jurisdictions in Canada and abroad. The case of Ontario's long-term care (LTC) policy evolution - from the 1940s until early 2013 -- shows how moving from compliance to deterrence oriented regulation can support consolidation of commercial providers' ownership and increase the likelihood of non-profit and public providers outsourcing their management.

West European and East Asian Perspectives on Defense, Deterrence and Strategy. Volume 3. Spanish Perspectives on Defense, Deterrence and Strategy.

DTIC Science & Technology

1984-05-16

sovereignty over the Tarfaya strip (between Western Sahara and post -colonial Morocco), over the whole of the Western Sahara and over the Spanish enclaves...veillance post , and a supply and repair vessel in the Mediterranean. Admiral of the Fleet Lewin said around the same time that the importance of Gibraltar...5.3.2 El Pais Self-appointed diario independiente de la manana. Its editorial line is controlled by Sr. Javier Pradera, former Communist Party member

What Happens to Deterrence as Nuclear Weapons Decrease Toward Zero?

NASA Astrophysics Data System (ADS)

Drell, Sidney

2011-04-01

Steps reducing reliance on deployed nuclear weapons en route to zero will be discussed. They include broadly enhancing cooperation and transparency agreements beyond the provisions for verifying limits on deployed strategic nuclear warheads and delivery systems in the New START treaty. Two questions that will be addressed are: What conditions would have to be established in order to maintain strategic stability among nations as nuclear weapons recede in importance? What would nuclear deterrence be like in a world without nuclear weapons?

Preparing for the 2009 Nuclear Posture Review: Post-Cold War Nuclear Deterrence and the 2001 NPR Debate

DTIC Science & Technology

2008-12-01

of relying upon the minimalist idea of maintaining strategic deterrence only to prevent nuclear attack.[87] Joseph Pilat agrees and tries to make...Record Straight,” The Washington Quarterly 28, no. 3 (Summer 2005): 136. 87. Payne (2005), Op. Cit., 140. 88. Pilat , Op. Cit., 43. 89. Payne (2005...152. 91. Payne (2005), Op. Cit., 142. 92. Ibid., 146. 93. Joseph F. Pilat , “The New Triad,” in Wirtz and Larson, eds., Nuclear Transformation

Deterrence and the United States Coast Guard: Enhancing Current Practice with Performance Measures

DTIC Science & Technology

2012-03-01

Talley,  Jin , Kite Powell,  The US Coast Guard Vessel Inspection Programme (2005)  Deterrence and the United States Coast Guard: Enhancing Current...practical problem-solving, not from theory or strategy. As a result, the activities are fractured and may not even be recognized as related to...of Sun Tzu’s admonition: “Strategy without tactics is the slowest route to victory. Tactics without strategy is the noise before defeat.” The US

Weapons of mass destruction in the developing world. What are the operational options. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Minner, D.K.

1992-06-19

The proliferation in quantity and quality of weapons of mass destruction serve as a threat of great consequence to U.S. operational forces. Operational options for action are explored within the national military strategy concepts of forward presence, deterrence, and crisis/regional contingency response. Three questions and associated issues related to operational art are posed for each concept: (1) what condition must be produced to achieve the strategic goal, (2) what events will most likely result in the desired condition, and (3) how should resources be applied to produce those events. The resulting analysis offers the following conclusions: (1) complementary efforts bymore » all instruments of national power--political, diplomatic, economic, and military--are necessary; (2) knowledge, training, and equipment are the first line of defense; (3) persuasion as well as confrontation is necessary; (4) effective deterrence requires capability, credibility, and communication; and (5) training and weapons for retaliation-in-kind remain the final alternative.« less

Joseph A. Burton Forum Award: Some Nuclear Weapons Dilemmas

NASA Astrophysics Data System (ADS)

May, Michael

2014-03-01

Nuclear weapons pose a combination of political and ethical dilemmas the solution to which has not been found. On one hand, in the view of both US government leaders and US allies, nuclear deterrence continues to play an essential part in the US role as the ultimate source of military strength for the alliances among the major democratic countries. It also continues to be in demand by countries that believe themselves to be isolated and threatened. On the other hand, nuclear weapons, besides being effective deterrents, can cause unprecedented loss of life and risk the demise of civilizations. No ban or technical precaution could prevent the rebuilding of nuclear weapons in a crisis. No diplomatic arrangement to date has erased the threat of invasion and war in the world. Only the abandonment of war and the threat of war as instruments of policy can make nuclear weapons obsolete. The slow, halting, risky road to that end remains the only hope for a world in which lasting solutions to the nuclear dilemmas are possible.

Botanicals as eco friendly biorational alternatives of synthetic pesticides against Callosobruchus spp. (Coleoptera: Bruchidae)-a review.

PubMed

Kedia, Akash; Prakash, Bhanu; Mishra, Prashant Kumar; Singh, Priyanka; Dubey, Nawal Kishore

2015-03-01

The article presents the potential of botanicals in the management of Callosobruchus spp., the primary insect pest causing deterioration to a variety of stored legume grains. Different botanical formulations have been reported time to time showing pronounced insecticidal activity, repellence to pest, oviposition deterrency, adult emergence inhibition, ovicidal, larvicidal, pupaecidal activity and feeding deterrency based on their contact toxicity and fumigation effects. Some of the botanicals have also been practically proved efficacious to protect the stored food commodities from the bruchids during storage conditions. Such botanical formulations have shown their promise in integrated management of the pest as semiochemicals by showing behaviour altering efficacy against the bruchids, thereby, reducing the induced pest resistance problem which is frequently reported with synthetic pesticides. Hence, they may be recommended in food security programmes as eco-friendly and biorational alternatives of synthetic pesticides providing integrated management of the losses of stored food commodities due to infestation of bruchids.

Activity of Schinus areira (Anacardiaceae) essential oils against the grain storage pest Tribolium castaneum.

PubMed

Descamps, Lilian R; Sánchez Chopa, Carolina; Ferrero, Adriana A

2011-06-01

Essential oils extracted from leaves and fruits of Schinus areira (Anacardiaceae) were tested for their repellent, toxic and feeding deterrent properties against Tribolium castaneum (Coleoptera: Tenebrionidae) larvae and adults. A topical application assay was employed for the contact toxicity study and filter paper impregnation for the fumigant assay. A treated diet was also used to evaluate the repellent activity and a flour disk bioassay for the feeding deterrent action and nutritional index alteration. The essential oil of the leaves contained mainly monoterpenoids, with alpha-phellandrene, 3-carene and camphene predominant, whereas that from the fruits contained mainly alpha-phellandrene, 3-carene and beta-myrcene. The leaf essential oil showed repellent effects, whereas that from the fruit was an attractant. Both oils produced mortality against larvae in topical and fumigant bioassays, but fumigant toxicity was not found against adults. Moreover, both essential oils produced some alterations in nutritional index. These results show that the essential oils from S. areira could be applicable to the management of populations of Tribolium castaneum.

Interpreting labels of abuse-deterrent opioid analgesics.

PubMed

Webster, Lynn R

To provide an overview of available abuse-deterrent opioids (ADOs) and the labeling text that describes abuse-deterrent (AD) properties. A nonsystematic review of ADO literature and regulatory documents guiding their development. A critical assessment and discussion of common routes of opioid abuse, AD methods and properties, US Food and Drug Administration (FDA) study requirements to achieve AD labeling, and brief guide to understanding AD labels. The FDA has issued guidance as incentive and direction to industry to develop ADOs as one component of a multi-pronged public-health strategy to combat opioid abuse and misuse. The guidance describes separate categories of premarket and postmarket studies and makes recommendations for claims that may be made based on study findings. Ten ADOs have FDA-approved labeling attesting to AD properties. Available formulations that fail to conform to FDA guidance in study and labeling recommendations cannot be considered ADO. Formulations with AD properties are expected to reduce risk compared to the same agents without AD properties but cannot prevent all abuse and adverse clinical outcomes.

What's holding back abuse-deterrent opioid formulations? Considering 12 U.S. stakeholders.

PubMed

Pergolizzi, Joseph V; Taylor, Robert; LeQuang, Jo Ann; Raffa, Robert B

2018-06-01

There is no greater public health threat at this time in America than the opioid abuse crisis, and a systematic, level-headed, coherent, and unified approach is needed. Among the many things that have been proposed to help reduce opioid abuse is the development of opioid analgesic products in abuse-deterrent formulations (ADFs). This seems to make perfect sense. Areas covered: In this article, the viewpoints of 12 stakeholders (physicians, pain patients, payers, manufacturers, regulators, law enforcement, hospitals, first responders, elected officials, rehabilitation centers, opioid addicts, and the general public) were considered in terms of how ADF opioids are regarded and might contribute potential impediments to more widespread use. This is a narrative review based on the literature. Stakeholders were not surveyed directly. Expert opinion: Although abuse-deterrent technology for opioid analgesics has been available for several years, ADFs have not gained widespread acceptance. ADF products serve an important but limited purpose, but their incremental costs may serve as a 'mixed message' for many of the stakeholders concerned about cost containment.

Deterrence and nuclear strategy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lodal, J.M.

1980-01-01

Mr. Lodal sees the social aspects of an effective deterrence policy as no less important than its technological aspects; further, programs and policies must be put in place that enhance social cohesion, that demonstrate the will to carry through on the strategy that we in the Western world subscribe to. It is the challenge of this political objective that most demands our attention. He feels that, if we are to remain secure, we must restore not only political cohesion to the Western alliance but a sensible political relationship between the United States and the Soviet Union as well. Such amore » relationship will of necessity provide for arms control. If we are able to maintain the arms control agreements reached to date, including the ABM treaty and SALT II, we will be a step ahead. It is to be hoped that the administration taking office in January of 1981 can restore order to our political relationships and avoid the necessity of a major defense program change such as the one suggested here. Unfortunately, the risk of this not happening is very real, according to Mr. Lodal. Therefore, the conceptualizing of concrete policies to improve our strategic nuclear posture becomes imperative. Adding limited defenses to our traditional doctrine is simply the best of a set of difficult choices. Such defenses would make our threatened use of battlefield nuclear weapons more credible, and they would restore a measure of extended deterrence; battlefield weapons could be used with the knowledge that only a massive Soviet attack would harm the US homeland. Thus, the defense would create a second firebreak in the ladder of escalation.« less

Weak laws against acid attacks on women: an Indian perspective.

PubMed

Ahmad, Nehaluddin

2012-01-01

Acid attacks, especially on women, have seen an alarming growth in India over the last decade. While these attacks can be attributed to various factors such as the social weakness of women in a male-dominated society, the situation is exacerbated by the general neglect of the lawmakers. As acid is inexpensive and easily available, it serves as an ideal weapon for the perpetrators. Further, as this offence is bailable in certain situations, the punishment does not act as a sufficient deterrent in most cases. This paper describes the horrendous effects that acid attacks have on the victims physically, psychologically and socially. It also examines the contemporary laws governing acid attacks on victims and offenders. Ideas for a better legal approach will also be examined with special reference to acid attacks as a crime, and the validity of specific legal provisions for female victims.

The effects of police contact on trajectories of violence: a group-based, propensity score matching analysis.

PubMed

Ward, Jeffrey T; Krohn, Marvin D; Gibson, Chris L

2014-02-01

This study uses a life course framework to investigate how police contacts may serve as a potential turning point in a violent crime trajectory. Drawing on the central ideas from deterrence and labeling theories, we determine whether individuals on different violent offending trajectories increase or decrease their offending following a police contact. Analyzing nine waves of data from the Rochester Youth Development Study, an integrated propensity score matching and latent class growth model was used. First, three violent trajectory groups emerged including high offenders, non-offenders, and low offenders. Second, after accounting for selection bias using propensity score matching procedures, experiencing a police contact increased the likelihood of future violent offending for the entire sample and for those who were on a low violent-offending trajectory specifically. These findings are interpreted as partial support for labeling theory. Limitations of the study and directions for future research are discussed.

Oviposition Deterrent and Larvicidal and Pupaecidal Activity of Seven Essential Oils and their Major Components against Culex quinquefasciatus Say (Diptera: Culicidae): Synergism–antagonism Effects

PubMed Central

Andrade-Ochoa, Sergio; Sánchez-Aldana, Daniela; Chacón-Vargas, Karla Fabiola; Rivera-Chavira, Blanca E.; Camacho, Alejandro D.; Nogueda-Torres, Benjamín

2018-01-01

The larvicidal activity of essential oils cinnamon (Cinnamomum verum J. Presl), Mexican lime (Citrus aurantifolia Swingle) cumin (Cuminum cyminum Linnaeus), clove (Syzygium aromaticum (L.) Merr. & L.M.Perry), laurel (Laurus nobilis Linnaeus), Mexican oregano (Lippia berlandieri Schauer) and anise (Pimpinella anisum Linnaeus)) and their major components are tested against larvae and pupae of Culex quinquefasciatus Say. Third instar larvae and pupae are used for determination of lethality and mortality. Essential oils with more than 90% mortality after a 30-min treatment are evaluated at different time intervals. Of the essential oils tested, anise and Mexican oregano are effective against larvae, with a median lethal concentration (LC50) of 4.7 and 6.5 µg/mL, respectively. Anise essential oil and t-anethole are effective against pupae, with LC50 values of 102 and 48.7 µg/mL, respectively. Oregano essential oil and carvacrol also have relevant activities. A kinetic analysis of the larvicidal activity, the oviposition deterrent effect and assays of the effects of the binary mixtures of chemical components are undertaken. Results show that anethole has synergistic effects with other constituents. This same effect is observed for carvacrol and thymol. Limonene shows antagonistic effect with β-pinene. The high larvicidal and pupaecidal activities of essential oils and its components demonstrate that they can be potential substitutes for chemical compounds used in mosquitoes control programs. PMID:29443951

The comparative effectiveness of two digit-sucking deterrent methods.

PubMed

Bourne, C O

2005-09-01

A study was conducted to compare the effectiveness of the crib and positive reinforcement in eliminating anterior open bites and increased overjets caused by digit-sucking. The overjet and overbite were measured using an overjet ruler at the start and end of the seventeen-week observation period. Forty patients consented to participate but measurements were only obtained for 11 subjects. The trend in this study is that the crib is more effective than positive reinforcement in preventing digit-sucking.

Picking up the shield: Incorporating defense into strategic nuclear doctrine. Research report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruotsala, M.G.

Picking up the Shield is an interesting and enlightening account of the evolution of strategic nuclear doctrine. It puts the offense-defense relationship into a historical perspective that lends important insight into the ongoing debate over strategic defenses. Although this debate centers on the active defenses contemplated by the strategic defense initiative, Lt Col Michael G. Ruotsala makes the point that passive defenses are also an important component of strategic defense. He sees the inherent passive defenses of the Triad as being a key to maintaining offense-oriented deterrence, and he makes a good case for survivable Peacekeeper basing and a smallmore » mobile intercontinental ballistic missile (ICBM) to enhance deterrence and pave the way for active defense. Although the future may hold a strategic defense with new, even revolutionary, weapons, any future program will embody old concepts of offense and defense. For the foreseeable future, offensive strategic forces will continue to play a dominant role in US defense policy. However, strategic defenses are consistent with US strategic doctrine. More important for deterrence, defenses are consistent with Soviet doctrine. Clearly, complementing roles for both the offense and defense are critical for developing a doctrine that enhances deterrence of a nuclear exchange between the United States and the Soviet Union. It is also clear that Picking up the Shield makes a significant contribution to understanding the challenge we face as we incorporate defense into strategic nuclear doctrine.« less

West European and East Asian perspectives on defense, deterrence, and strategy. Volume 2. Western European perspectives on defense, deterrence, and strategy. Technical report, 1 December 1982-15 May 1984

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pfaltzgraff, R.L.; Davis, J.K.; Dougherty, J.E.

1984-05-16

A survey of contemporary West European perspectives on defense, deterrence, and strategy, with special emphasis on the role of nuclear weapons deployed in, or assigned to, the NATO area. Changes have occurred during the past decade in the relative military strength of NATO and the Warsaw Pact, particularly as a result of the substantial growth in Soviet nuclear-capable systems and conventional forces assigned to Europe, and the momentum manifested by the Soviet Union in its deployments of intercontinental ballistic missiles. There has also been a substantial shift in West European thinking and attitudes about security and strategy. Together, these trendsmore » have created a need to reassess the posture of NATO forces generally, and especially nuclear weapons, both in a broader Euro-strategic framework and on the Central Front in the 1980s. The survey is on such issues as the future of the British and French national strategic nuclear forces; the role of the U.S.-strategic nuclear forces in the deterrence of conflict in Europe; the prospects of raising the nuclear threshold by the deployment of new conventional technologies; the impact of strategic defense initiatives on U.S.-NATO security; and the modernization of NATO intermediate-range nuclear capabilities, especially in light of the continuing deployment of the Soviet Union of new generation Euro-strategic forces targeted against Western Europe.« less

Melanoma risk: adolescent females' perspectives on skin protection pre/post-viewing a ultraviolet photoaged photograph of their own facial sun damage.

PubMed

Eastabrook, Suzette; Chang, Paul; Taylor, Myra F

2018-03-01

Suntanning increases skin cancer risk and prematurely ages skin. Photoageing photography is an effective means of increasing adult ultraviolet radiation (UVR) awareness and skin-protection practices. While adults' largely positive suntanning-deterrence responses to photoageing photography are well-documented, comparatively little is known about the deterrence effectiveness of photoageing photography with adolescents. To help fill this knowledge gap, in-depth interviews were collected from 10 adolescent females and were subsequently subjected to interpretive phenomenological analysis. The emergent central theme - Having a tan and looking good in the short-term is okay, however, in the longer-term you can end up looking far worse… but still a tan is worth it - and its component subthemes reveal that the adolescent female's desire for a suntan is largely appearance driven. While photoaged photography is effective in increasing their awareness of the skin damage that UVR exposure causes, it does not alter their suntanning intentions. The analysis also revealed that one of the major barriers to adolescent females' adoption of skin-protective behaviours is their belief in their own invincibility. Hence, skin-protection interventions that lessen the aura of invincibility around adolescent females' understanding of their risk for developing skin cancers are vital to reducing the incidence of malignant melanoma.

Toxicity of ar-curcumene and epi-β-bisabolol from Hedychium larsenii (Zingiberaceae) essential oil on malaria, chikungunya and St. Louis encephalitis mosquito vectors.

PubMed

AlShebly, Mashael Marzouq; AlQahtani, Fatma Saeed; Govindarajan, Marimuthu; Gopinath, Kasi; Vijayan, Periasamy; Benelli, Giovanni

2017-03-01

Mosquitoes act as vectors of key pathogens and parasites. Plant essential oils have been recognized as important sources of biopesticides, which do not induce resistance and have limited toxic effects on human health and non-target organisms. In this research, we evaluated the larvicidal and oviposition deterrence activity of Hedychium larsenii essential oil (EO) and its major compounds ar-curcumene and epi-β-bisabolol. Both molecules showed high toxicity against early third instars of Anopheles stephensi (LC 50 =10.45 and 14.68µg/ml), Aedes aegypti (LC 50 =11.24 and 15.83µg/ml) and Culex quinquefasciatus (LC 50 =12.24 and 17.27µg/ml). In addition, low doses of ar-curcumene and epi-β-bisabolol were effective as oviposition deterrents against the three tested mosquito species. Notably, the acute toxicity of H. larsenii oil and its major compounds against the mosquito biocontrol agent Poecilia reticulata was low, with LC 50 higher than 1500ppm. Overall, the results from this study revealed that ar-curcumene and epi-β-bisabolol from the H. larsenii oil can be considered for the development of novel and effective mosquito larvicides. Copyright © 2016 Elsevier Inc. All rights reserved.

Effects of two commercial neem-based insecticides on lone star tick, Amblyomma americanum (L.) (Acari: Ixodidae): deterrence, mortality, and reproduction

USDA-ARS?s Scientific Manuscript database

The lone star tick, Amblyomma americanum (L.), is a widely distributed three-host obligate blood-feeding parasite in the United States and Mexico. It mostly attaches to white-tailed deer, Odocoilus virginianus (Zimmerman) and wild turkey, Meleagris gallopavo L., as well as a wide variety of other do...

The Ring of Gyges: Anonymity and Technological Advance’s Effect on the Deterrence of Nonstate Actors in 2035

DTIC Science & Technology

2012-10-01

Technical Information Center, 1972), 723–24. A case in point is the Manhattan Project undertaken by the United States to produce the first atomic weapon. A...capital and operations costs from 1942 through 1945. Costs adjusted using a base year of 1944 (the year of highest Manhattan Project expenditures). 39

BdorCSP2 Is Important for Antifeed and Oviposition-Deterring Activities Induced by Rhodojaponin-III against Bactrocera dorsalis

PubMed Central

Dong, Xiaolin; Wang, Peidan; Hu, Meiying; Zhong, Guohua

2013-01-01

Rhodojaponin-III is a nonvolatile botanical grayanoid diterpene compound, which has antifeedant and oviposition deterrence effects against many kinds of insects. However, the molecular mechanism of the chemoreception process remains unknown. In this study, the important role of BdorCSP2 in the recognition of Rhodojaponin-III was identified. The full length cDNA encoding BdorCSP2 was cloned from legs of Bactrocera dorsalis. The results of expression pattern revealed that BdorCSP2 was abundantly expressed in the legs of adult B. dorsalis. Moreover, the expression of BdorCSP2 could be up-regulated by Rhodojaponin-III. In order to gain comprehensive understanding of the recognition process, the binding affinity between BdorCSP2 and Rhodojaponin-III was measured by fluorescence binding assay. Silencing the expression of BdorCSP2 through the ingestion of dsRNA could weaken the effect of oviposition deterrence and antifeedant of Rhodojaponin-III. These results suggested that BdorCSP2 of B. dorsalis could be involved in chemoreception of Rhodojaponin-III and played a critical role in antifeedant and oviposition behaviors induced by Rhodojaponin-III. PMID:24155937

An Ethylene-Protected Achilles’ Heel of Etiolated Seedlings for Arthropod Deterrence

PubMed Central

Boex-Fontvieille, Edouard; Rustgi, Sachin; von Wettstein, Diter; Pollmann, Stephan; Reinbothe, Steffen; Reinbothe, Christiane

2016-01-01

A small family of Kunitz protease inhibitors exists in Arabidopsis thaliana, a member of which (encoded by At1g72290) accomplishes highly specific roles during plant development. Arabidopsis Kunitz-protease inhibitor 1 (Kunitz-PI;1), as we dubbed this protein here, is operative as cysteine PI. Activity measurements revealed that despite the presence of the conserved Kunitz-motif the bacterially expressed Kunitz-PI;1 was unable to inhibit serine proteases such as trypsin and chymotrypsin, but very efficiently inhibited the cysteine protease RESPONSIVE TO DESICCATION 21. Western blotting and cytolocalization studies using mono-specific antibodies recalled Kunitz-PI;1 protein expression in flowers, young siliques and etiolated seedlings. In dark-grown seedlings, maximum Kunitz-PI;1 promoter activity was detected in the apical hook region and apical parts of the hypocotyls. Immunolocalization confirmed Kunitz-PI;1 expression in these organs and tissues. No transmitting tract (NTT) and HECATE 1 (HEC1), two transcription factors previously implicated in the formation of the female reproductive tract in flowers of Arabidopsis, were identified to regulate Kunitz-PI;1 expression in the dark and during greening, with NTT acting negatively and HEC1 acting positively. Laboratory feeding experiments with isopod crustaceans such as Porcellio scaber (woodlouse) and Armadillidium vulgare (pillbug) pinpointed the apical hook as ethylene-protected Achilles’ heel of etiolated seedlings. Because exogenous application of the ethylene precursor 1-aminocyclopropane-1-carboxylic acid (ACC) and mechanical stress (wounding) strongly up-regulated HEC1-dependent Kunitz-PI;1 gene expression, our results identify a new circuit controlling herbivore deterrence of etiolated plants in which Kunitz-PI;1 is involved. PMID:27625656

Managing severe pain and abuse potential: the potential impact of a new abuse-deterrent formulation oxycodone/naltrexone extended-release product.

PubMed

Pergolizzi, Joseph V; Taylor, Robert; LeQuang, Jo Ann; Raffa, Robert B

2018-01-01

Proper management of severe pain represents one of the most challenging clinical dilemmas. Two equally important goals must be attained: the humanitarian/medical goal to relieve suffering and the societal/legal goal to not contribute to the drug abuse problem. This is an age-old problem, and the prevailing emphasis placed on one or the other goal has resulted in pendulum swings that have resulted in either undertreatment of pain or the current epidemic of misuse and abuse. In an effort to provide efficacious strong pain relievers (opioids) that are more difficult to abuse by the most dangerous routes of administration, pharmaceutical companies are developing products in which the opioid is manufactured in a formulation that is designed to be tamper resistant. Such a product is known as an abuse-deterrent formulation (ADF). ADF opioid products are designed to deter or resist abuse by making it difficult to tamper with the product and extracting the opioid for inhalation or injection. To date, less than a dozen opioid formulations have been approved by the US Food and Drug Administration to carry specific ADF labeling, but this number will likely increase in the coming years. Most of these products are extended-release formulations.

Greenland shark (Somniosus microcephalus) feeding behavior on static fishing gear, effect of SMART (Selective Magnetic and Repellent-Treated) hook deterrent technology, and factors influencing entanglement in bottom longlines

PubMed Central

Sullivan, Rennie; Hedges, Kevin J.

2018-01-01

The Greenland Shark (Somniosus microcephalus) is the most common bycatch in the Greenland halibut (Reinhardtius hippoglossoides) bottom longline fishery in Cumberland Sound, Canada. Historically, this inshore fishery has been prosecuted through the ice during winter but winter storms and unpredictable landfast ice conditions since the mid-1990s have led to interest in developing a summer fishery during the ice-free season. However, bycatch of Greenland shark was found to increase substantially with 570 sharks captured during an experimental Greenland halibut summer fishery (i.e., mean of 6.3 sharks per 1,000 hooks set) and mortality was reported to be about 50% due in part to fishers killing sharks that were severely entangled in longline gear. This study investigated whether the SMART (Selective Magnetic and Repellent-Treated) hook technology is a practical deterrent to Greenland shark predation and subsequent bycatch on bottom longlines. Greenland shark feeding behavior, feeding kinematics, and variables affecting entanglement/disentanglement and release are also described. The SMART hook failed to deter Greenland shark predation, i.e., all sharks were captured on SMART hooks, some with more than one SMART hook in their jaw. Moreover, recently captured Greenland sharks did not exhibit a behavioral response to SMART hooks. In situ observations of Greenland shark feeding show that this species uses a powerful inertial suction mode of feeding and was able to draw bait into the mouth from a distance of 25–35 cm. This method of feeding is suggested to negate the potential deterrent effects of electropositive metal and magnetic alloy substitutions to the SMART hook technology. The number of hooks entangled by a Greenland shark and time to disentangle and live-release a shark was found to increase with body length. PMID:29785345

The law isn't everything: The impact of legal and non-legal sanctions on motorists' drink driving behaviors.

PubMed

Freeman, James; Szogi, Elizabeth; Truelove, Verity; Vingilis, Evelyn

2016-12-01

The effectiveness of drink driving countermeasures (such as sanctions) to deter motorists from driving over the legal limit is extremely important when considering the impact the offending behavior has on the community. However, questions remain regarding the extent that both legal and non-legal factors influence drink driving behaviors. This is of particular concern given that both factors are widely used as either sanctioning outcomes or in media campaigns designed to deter drivers (e.g., highlighting the physical risk of crashing). This paper reports on an examination of 1,253 Queensland motorists' perceptions of legal and non-legal drink driving sanctions and the corresponding deterrent impact of such perceptions on self-reported offending behavior. Participants volunteered to complete either an online or paper version of the questionnaire. Encouragingly, quantitative analysis of the data revealed that participants' perceptions of both legal sanctions (e.g., certainty, severity and swiftness) as well as non-legal sanctions (e.g., fear of social, internal or physical harm) were relatively high, with perceptual certainty being the highest. Despite this, a key theme to emerge from the study was that approximately 25% of the sample admitted to drink driving at some point in time. Multivariate analyses revealed six significant predictors of drink driving, being: males, younger drivers, lower perceptions of the severity of sanctions, and less concern about the social, internal, and physical harms associated with the offense. However, a closer examination of the data revealed that the combined deterrence model was not very accurate at predicting drink driving behaviors (e.g., 21% of variance). A range of non-legal deterrent factors have the potential to reduce the prevalence of drink driving although further research is required to determine how much exposure is required to produce a strong effect. Copyright © 2016 Elsevier Ltd and National Safety Council. All rights reserved.

Greenland shark (Somniosus microcephalus) feeding behavior on static fishing gear, effect of SMART (Selective Magnetic and Repellent-Treated) hook deterrent technology, and factors influencing entanglement in bottom longlines.

PubMed

Grant, Scott M; Sullivan, Rennie; Hedges, Kevin J

2018-01-01

The Greenland Shark ( Somniosus microcephalus ) is the most common bycatch in the Greenland halibut ( Reinhardtius hippoglossoides ) bottom longline fishery in Cumberland Sound, Canada. Historically, this inshore fishery has been prosecuted through the ice during winter but winter storms and unpredictable landfast ice conditions since the mid-1990s have led to interest in developing a summer fishery during the ice-free season. However, bycatch of Greenland shark was found to increase substantially with 570 sharks captured during an experimental Greenland halibut summer fishery (i.e., mean of 6.3 sharks per 1,000 hooks set) and mortality was reported to be about 50% due in part to fishers killing sharks that were severely entangled in longline gear. This study investigated whether the SMART (Selective Magnetic and Repellent-Treated) hook technology is a practical deterrent to Greenland shark predation and subsequent bycatch on bottom longlines. Greenland shark feeding behavior, feeding kinematics, and variables affecting entanglement/disentanglement and release are also described. The SMART hook failed to deter Greenland shark predation, i.e., all sharks were captured on SMART hooks, some with more than one SMART hook in their jaw. Moreover, recently captured Greenland sharks did not exhibit a behavioral response to SMART hooks. In situ observations of Greenland shark feeding show that this species uses a powerful inertial suction mode of feeding and was able to draw bait into the mouth from a distance of 25-35 cm. This method of feeding is suggested to negate the potential deterrent effects of electropositive metal and magnetic alloy substitutions to the SMART hook technology. The number of hooks entangled by a Greenland shark and time to disentangle and live-release a shark was found to increase with body length.

Dancing the Two-Step in Ontario’s Long-term Care Sector: More Deterrence-oriented Regulation = Ownership and Management Consolidation

PubMed Central

Daly, Tamara

2016-01-01

This paper explores shifts in public and private delivery over time through an analysis of Ontario’s approach to LTC funding and regulation in relation to other jurisdictions in Canada and abroad. The case of Ontario’s long-term care (LTC) policy evolution – from the 1940s until early 2013 -- shows how moving from compliance to deterrence oriented regulation can support consolidation of commercial providers’ ownership and increase the likelihood of non-profit and public providers outsourcing their management. PMID:27777495

West European and East Asian Perspectives on Defense, Deterrence and Strategy. Volume 4. Portuguese Perspectives on Defense, Deterrence and Strategy.

DTIC Science & Technology

1984-05-16

in U.S. military planning , the West has to face growing threats in the peripheral zones, namely in those that are essential to the supply of raw...to a re-definition of U.S. strategic planning . In accordance with the ’Maritime strategy" of deployment from the U.S. territory of important military...Socialist Party, and the editor of the Communist daily, O’Diario, Miguel Urbano Rodriques. Neutralist doctrines are abundantly expressed in Liber 25

Nothing New Under the Sun: Benefiting from the Great Lessons of History to Develop a Coherent Cyberspace Deterrence Strategy

DTIC Science & Technology

2012-05-12

LESSONS OF HISTORY TO DEVELOP A COHERENT CYBERSPACE DETERRENCE STRATEGY 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHDR!SI 5d. PROJECT ...AFOSR-82-1234. 5c. PROGRAM ELEMENT NUMBER. Enter all program element numbers as they appear in the report, e.g. 61101 A. 5d. PROJECT NUMBER...Enter all project numbers as they appear in the report, e.g. 1F665702D1257; ILIR. 5e. TASK NUMBER. Enter all task numbers as they appear in the

Biosynthesis and Regulation of Bioprotective Alkaloids in the Gramineae Endophytic Fungi with Implications for Herbivores Deterrents.

PubMed

Luo, Hongping; Xie, Longxiang; Zeng, Jie; Xie, Jianping

2015-12-01

Four kinds of bioprotective alkaloids-peramine, loline, ergot alkaloid, indole-diterpenes, produced by grass-fungal endophyte symbioses, are deterrents or toxic to vertebrate and invertebrate herbivores. Ergot alkaloids have pharmacological properties and widely are used clinically. The regulation of alkaloids biosynthesis is under intensive study to improve the yield for better agricultural and medicinal application. In this paper, we summarize the structure, related genes, regulation, and toxicity of alkaloids. We focus on the biosynthesis and the regulation network of alkaloids.

Consequence Management: A Disconnect Between National Security Policy and Force Structure?

DTIC Science & Technology

2001-03-15

effects or the consequences of a detonated and/or released weapon(s) has only recently been given much attention. Despite several warnings of the...with the exposure ? Second, the time required to establish and field a regional JTF would prevent the force from having a strong positive effect on the... outcome of the situation. One of the critical missions of a successful consequence management force is its ability to provide a strong deterrent

Evaluation of Abuse-Deterrent or Tamper-Resistant Opioid Formulations on Overall Health Care Expenditures in a State Medicaid Program.

PubMed

Keast, Shellie L; Owora, Arthur; Nesser, Nancy; Farmer, Kevin

2016-04-01

The development of abuse-deterrent opioid prescription medications is a priority at the national level. Pharmaceutical manufacturers have begun marketing new formulations of currently available opioids that meet higher abuse resistance standards. Little information is available regarding the impact of these formulations on overall health care expenditures. To (a) examine the relationship between health care expenditures and use of brand abuse-deterrent or tamper-resistant (ADTR) extended-release opioids versus standard dosage form (SDF) extended-release opioids in a state Medicaid population, and (b) determine whether this relationship was influenced by member-specific characteristics. The study is a cross-sectional review of Oklahoma Medicaid members (aged ≥ 21 years) with at least 1 paid pharmacy claim for long-acting opioids between September 2013 and August 2014. Members who were adherent to extended-release opioid products were classified into ADTR and SDF opioid groups. The relationship between health care expenditures (prescription, medical, and overall) and opioid groups was examined using multiple linear regression models. The impact of member-specific characteristics (age, sex, race, urban classifications, and various comorbidities) on this relationship was examined. Prescription spending ($9,265,554) accounted for 35% of overall health care expenditures ($26,304,693) among 938 members during the 12-month reference period. Total prescription expenditures were higher among ADTR than SDF user groups, and the difference in median expenditures between these 2 groups was larger among members with more comorbidities, as measured by the Charlson Comorbidity Index score. Overall, ADTR users had higher median total health care and medical expenditures, and the difference in median expenditures was dependent on whether a member had comorbidities of addiction or not (higher expenditures were observed among members with comorbidities of addiction). The abuse and misuse of medically prescribed opioid products is a growing health epidemic. A variety of attempts have been made to reduce the potential of abuse and misuse of these products, including changes to product formulations. The results of this study indicate that both prescription spending and physician and pharmacy spending combined may be increased with the use of these new products because of higher pricing. Study findings also suggest that the use of ADTR opioids among members with comorbidities of addiction may be related to slightly lower overall health care and medical expenditures than those among members without comorbidities of addiction. Further research is required to answer questions regarding the comparative effectiveness of existing opioid prescription formulations. No outside funding supported this research. Nesser is employed by the Oklahoma Health Care Authority, and Keast is a contractual employee for the Oklahoma Health Care Authority. The authors declare no other conflicts of interest. Study design was primarily contributed by Keast, along with Nesser and Farmer. Keast took the lead in data collection, while data interpretation was primarily performed by Owora, along with Keast and assisted by Nesser and Farmer. The manuscript was written and revised by all authors equally.

Attitudes and doping: a structural equation analysis of the relationship between athletes' attitudes, sport orientation and doping behaviour

PubMed Central

2007-01-01

Background For effective deterrence methods, individual, systemic and situational factors that make an athlete or athlete group more susceptible to doping than others should be fully investigated. Traditional behavioural models assume that the behaviour in question is the ultimate end. However, growing evidence suggests that in doping situations, the doping behaviour is not the end but a means to an end, which is gaining competitive advantage. Therefore, models of doping should include and anti-doping policies should consider attitudes or orientations toward the specific target end, in addition to the attitude toward the 'tool' itself. Objectives The aim of this study was to empirically test doping related dispositions and attitudes of competitive athletes with the view of informing anti-doping policy developments and deterrence methods. To this end, the paper focused on the individual element of the drug availability – athlete's personality – situation triangle. Methods Data were collected by questionnaires containing a battery of psychological tests among competitive US male college athletes (n = 199). Outcome measures included sport orientation (win and goal orientation and competitiveness), doping attitude, beliefs and self-reported past or current use of doping. A structural equation model was developed based on the strength of relationships between these outcome measures. Results Whilst the doping model showed satisfactory fit, the results suggested that athletes' win and goal orientation and competitiveness do not play a statistically significant role in doping behaviour, but win orientation has an effect on doping attitude. The SEM analysis provided empirical evidence that sport orientation and doping behaviour is not directly related. Conclusion The considerable proportion of doping behaviour unexplained by the model suggests that other factors play an influential role in athletes' decisions regarding prohibited methods. Future research, followed by policy development, should incorporate these factors to capture the complexity of the doping phenomenon and to identify points for effective anti-doping interventions. Sport governing bodies and anti-doping organisations need to recognise that using performance enhancements may be more of a rational, outcome optimizing behaviour than deviance and consider offering acceptable alternative performance-enhancing methods to doping. PMID:17996097

Countering the Effects of Violent Transnational Crime: Major Findings of the Technical Seminar

DTIC Science & Technology

2008-05-01

reconstitution of the violent transnational criminal groups occurs, both in quantitative and qualitative terms. Currently, only successive operations over...that 6 internationally -recognized experts were assembled at the technical seminar, and issued a personal plea that they as a collective take steps to...the deterrence theory principles can be applied against distributed, franchise -type criminal organizations, and documented that a series of

Conventional Expeditionary Forces: A 21st Century Triad for Strategic Deterrence

DTIC Science & Technology

2009-05-27

testing and transfers of nuclear materials, the ability to effectively monitor and track all such activities 100% of the time does not exist at present nor...Limited Test Ban Treaty of 1963 sought to stabilize the arms race and reduce environmental damage by banning atmospheric, sea-based, and space-based...nuclear weapons tests , thereby limiting future testing to underground conditions, and was signed 139

Variable percentage sampler

DOEpatents

Miller, Jr., William H.

1976-01-01

A remotely operable sampler is provided for obtaining variable percentage samples of nuclear fuel particles and the like for analyses. The sampler has a rotating cup for a sample collection chamber designed so that the effective size of the sample inlet opening to the cup varies with rotational speed. Samples of a desired size are withdrawn from a flowing stream of particles without a deterrent to the flow of remaining particles.

Efficacy of a sensory deterrent and pipe modifications in decreasing entrainment of juvenile green sturgeon (Acipenser medirostris) at unscreened water diversions

PubMed Central

Poletto, Jamilynn B.; Cocherell, Dennis E.; Mussen, Timothy D.; Ercan, Ali; Bandeh, Hossein; Levent Kavvas, M.; Cech, Joseph J.; Fangue, Nann A.

2014-01-01

Water projects designed to extract fresh water for local urban, industrial and agricultural use throughout rivers and estuaries worldwide have contributed to the fragmentation and degradation of suitable habitat for native fishes. The number of water diversions located throughout the Sacramento–San Joaquin watershed in California's Central Valley exceeds 3300, and the majority of these are unscreened. Many anadromous fish species are susceptible to entrainment into these diversions, potentially impacting population numbers. In the laboratory, juvenile green sturgeon (Acipenser medirostris) have been shown to have high entrainment rates into unscreened diversions compared with those of other native California fish species, which may act as a significant source of mortality for this already-threatened species. Therefore, we tested the efficacy of a sensory deterrent (strobe light) and two structural pipe modifications (terminal pipe plate and upturned pipe configuration) in decreasing the entrainment of juvenile green sturgeon (mean mass ± SEM = 162.9 ± 4.0 g; mean fork length = 39.4 ± 0.3 cm) in a large (>500 kl) outdoor flume fitted with a water-diversion pipe 0.46 m in diameter. While the presence of the strobe light did not affect fish entrainment rates, the terminal pipe plate and upturned pipe modifications significantly decreased the proportion of fish entrained out of the total number tested relative to control conditions (0.13 ± 0.02 and 0.03 ± 0.02 vs. 0.44 ± 0.04, respectively). These data suggest that sensory deterrents using visual stimuli are not an effective means to reduce diversion pipe interactions for green sturgeon, but that structural alterations to diversions can successfully reduce entrainment for this species. Our results are informative for the development of effective management strategies to mitigate the impacts of water diversions on sturgeon populations and suggest that effective restoration strategies that balance agricultural needs with conservation programmes are possible. PMID:27293677

Testing and Contrasting Road Safety Education, Deterrence, and Social Capital Theories: A Sociological Approach to the Understanding of Male Drink-Driving in Chile's Metropolitan Region.

PubMed

Nazif, José Ignacio

2011-01-01

Three theories offer different explanations to the understanding of male drink-driving. In order to test road safety education, deterrence, and social capital theories, logistic regression analysis was applied to predict respondents' statements of having or not having engaged in actual drink-driving (DD). Variable for road safety education theory was whether a driver had graduated from a professional driving school or not. Deterrence theory was operationalized with a variable of whether a driver had been issued a traffic ticket or not. Social capital theory was operationalized with two variables, having children or not and having religion identification or not. Since both variables 'years of formal education' and 'years of driving experience' have been reported to be correlated to alcohol consumption and DD respectively, these were introduced as controls. In order to assess the significance of each variable statistically, Wald tests were applied in seven models. Results indicate on the one hand that road safety education variable is not statistically significant; and on the other, deterrence theory variable and social capital theory variable 'having children' were both statistically significant at the level of .01. Findings are discussed in reference to Chile's context. Data were taken from the "Road Users Attitudes and Behaviors towards Traffic Safety" survey from the National Commission of Road Safety of the Government of Chile (2005). The sample size was reported to be 2,118 (N of male drivers was 396). This survey was representative of Chile's Metropolitan Region road users' population.

Testing and Contrasting Road Safety Education, Deterrence, and Social Capital Theories: A Sociological Approach to the Understanding of Male Drink-Driving in Chile’s Metropolitan Region

PubMed Central

Nazif, José Ignacio

2011-01-01

Three theories offer different explanations to the understanding of male drink-driving. In order to test road safety education, deterrence, and social capital theories, logistic regression analysis was applied to predict respondents’ statements of having or not having engaged in actual drink-driving (DD). Variable for road safety education theory was whether a driver had graduated from a professional driving school or not. Deterrence theory was operationalized with a variable of whether a driver had been issued a traffic ticket or not. Social capital theory was operationalized with two variables, having children or not and having religion identification or not. Since both variables ‘years of formal education’ and ‘years of driving experience’ have been reported to be correlated to alcohol consumption and DD respectively, these were introduced as controls. In order to assess the significance of each variable statistically, Wald tests were applied in seven models. Results indicate on the one hand that road safety education variable is not statistically significant; and on the other, deterrence theory variable and social capital theory variable ‘having children’ were both statistically significant at the level of .01. Findings are discussed in reference to Chile’s context. Data were taken from the “Road Users Attitudes and Behaviors towards Traffic Safety” survey from the National Commission of Road Safety of the Government of Chile (2005). The sample size was reported to be 2,118 (N of male drivers was 396). This survey was representative of Chile’s Metropolitan Region road users' population. PMID:22105406

Electrophysiological Responses of Gustatory Receptor Neurons on the Labella of the Common Malaria Mosquito, Anopheles quadrimaculatus (Diptera: Culicidae).

PubMed

Sparks, Jackson T; Dickens, Joseph C

2016-05-11

We recorded electrical responses from sensory cells associated with gustatory sensilla on the labella of female Anopheles quadrimaculatus Say to salt, sucrose, quinine (a feeding deterrent), and the insect repellent, N,N-diethyl-3-methylbenzamide (DEET). A salt-sensitive cell responded to increasing concentrations of sodium chloride. A second cell was activated by increasing sucrose concentrations, while quinine, DEET, or a mixture of quinine + DEET elicited spike activity from a third cell, an apparent bitter- or deterrent-sensitive cell. Both quinine and DEET suppressed activity of the sugar-sensitive cell; sucrose suppressed activity of the bitter- or deterrent-sensitive cell. These results demonstrate separate gustatory pathways for a feeding stimulant and aversive contact cues mediated through distinct sensory inputs on the labellum. This sensory appendage may serve as a useful target to disrupt feeding behavior in this and other anopheline species, which transmit diseases like malaria to human populations. Published by Oxford University Press on behalf of Entomological Society of America 2016. This work is written by US Government employees and is in the public domain in the United States.

Can Nuclear Terrorists be Deterred?

NASA Astrophysics Data System (ADS)

Ferguson, Charles

2005-04-01

Conventional thinking since September 11, 2001, posits that nuclear-armed terrorists cannot be deterred. However, not all terrorist groups are alike. For instance, those that are strongly affiliated with a national territory or a constituency that can be held hostage are more likely to be self-deterred against using or even acquiring nuclear weapons. In contrast, international terrorist organizations, such as al Qaeda, or apocalyptic groups, such as Aum Shinrikyo, may welcome retaliatory nuclear strikes because they embrace martyrdom. Such groups may be immune to traditional deterrence, which threatens direct punishment against the group in question or against territory or people the terrorists' value. Although deterring these groups may appear hopeless, nuclear forensic techniques could provide the means to establish deterrence through other means. In particular, as long as the source of the nuclear weapon or fissile material could be identified, the United States could threaten a retaliatory response against a nation that did not provide adequate security for its nuclear weapons or weapons-usable fissile material. This type of deterrent threat could be used to compel the nation with lax security to improve its security to meet rigorous standards.

United States initiative for chemical weapons arms control. Master`s thesis, 2 August 1995-7 June 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scott, R.D.

1996-06-07

This research investigates the US policy initiative renouncing the employment of chemical weapons (CW). The focus of the research is to determine if such an initiative will achieve the national objective for implementation of the Chemical Weapons Convention (CWC). If the initiative does not meet the national objective are there feasible options for the United States Government (USG). In 1993, the USG established a policy banning the use of chemical weapons. This act may have won the battle for the moral high ground, but it will not deter nor eliminate the use of chemical weapons worldwide. The relative ease bymore » which a nation can take various combinations of chemical compounds and produce a lethal chemical agent makes deterrence and/or complete elimination virtually impossible. The US should continue to employ the elements of diplomatic, informational, military, and economic policy regarding nonproliferation inclusive of a proven deterrent-CW. No use of CW or any weapon of mass destruction is best, but until the CWC is ratified a deterrent should be maintained by the US.« less

Help seeking for cancer ‘alarm’ symptoms: a qualitative interview study of primary care patients in the UK

PubMed Central

Whitaker, Katriina L; Macleod, Una; Winstanley, Kelly; Scott, Suzanne E; Wardle, Jane

2015-01-01

Background Delay in help seeking for cancer ‘alarm’ symptoms has been identified as a contributor to delayed diagnosis. Aim To understand people’s help-seeking decision making for cancer alarm symptoms, without imposing a cancer context. Design and setting Community-based, qualitative interview study in the UK, using purposive sampling by sex, socioeconomic status, and prior help seeking, with framework analysis of transcripts. Method Interviewees (n = 48) were recruited from a community-based sample (n = 1724) of adults aged ≥50 years who completed a health survey that included a list of symptoms. Cancer was not mentioned. Participants reporting any of 10 cancer alarm symptoms (n = 915) and who had consented to contact (n = 482) formed the potential pool from which people were invited to an interview focusing on their symptom experiences. Results Reasons for help seeking included symptom persistence, social influence, awareness/fear of a link with cancer, and ‘just instinct’. Perceiving the symptom as trivial or ‘normal’ was a deterrent, as was stoicism, adopting self-management strategies, and fear of investigations. Negative attitudes to help seeking were common. Participants did not want to be seen as making a fuss, did not want to waste the doctor’s time, and were sometimes not confident that the GP could help. Conclusion Decision making about cancer alarm symptoms was complex. Recognition of cancer risk almost always motivated help seeking (more so than the fear of cancer being a deterrent), assisted by recent public-awareness campaigns. As well as symptom persistence motivating help seeking, it could also have the reverse effect. Negative attitudes to help seeking were significant deterrents. PMID:25624313

Help seeking for cancer 'alarm' symptoms: a qualitative interview study of primary care patients in the UK.

PubMed

Whitaker, Katriina L; Macleod, Una; Winstanley, Kelly; Scott, Suzanne E; Wardle, Jane

2015-02-01

Delay in help seeking for cancer 'alarm' symptoms has been identified as a contributor to delayed diagnosis. To understand people's help-seeking decision making for cancer alarm symptoms, without imposing a cancer context. Community-based, qualitative interview study in the UK, using purposive sampling by sex, socioeconomic status, and prior help seeking, with framework analysis of transcripts. Interviewees (n = 48) were recruited from a community-based sample (n = 1724) of adults aged ≥50 years who completed a health survey that included a list of symptoms. Cancer was not mentioned. Participants reporting any of 10 cancer alarm symptoms (n = 915) and who had consented to contact (n = 482) formed the potential pool from which people were invited to an interview focusing on their symptom experiences. Reasons for help seeking included symptom persistence, social influence, awareness/fear of a link with cancer, and 'just instinct'. Perceiving the symptom as trivial or 'normal' was a deterrent, as was stoicism, adopting self-management strategies, and fear of investigations. Negative attitudes to help seeking were common. Participants did not want to be seen as making a fuss, did not want to waste the doctor's time, and were sometimes not confident that the GP could help. Decision making about cancer alarm symptoms was complex. Recognition of cancer risk almost always motivated help seeking (more so than the fear of cancer being a deterrent), assisted by recent public-awareness campaigns. As well as symptom persistence motivating help seeking, it could also have the reverse effect. Negative attitudes to help seeking were significant deterrents. © British Journal of General Practice 2015.

Efficacy of indigenous plant extracts on the malaria vector Anopheles subpictus Grassi (Diptera: Culicidae)

PubMed Central

Elango, G.; Zahir, A. Abduz; Bagavan, A.; Kamaraj, C.; Rajakumar, G.; Santhoshkumar, T.; Marimuthu, S.; Rahuman, A. Abdul

2011-01-01

Background & objectives: Mosquito control is facing a threat due to the emergence of resistance to synthetic insecticides. Insecticides of plant origin may serve as suitable alternative biocontrol techniques in the future. The purpose of the present study was to assess the ethyl acetate, acetone and methanol extracts of Andrographis paniculata, Eclipta prostrata and Tagetes erecta leaves tested for oviposition-deterrent, ovicidal and repellent activities against malaria vector, Anopheles subpictus Grassi (Diptera: Culicidae). Methods: The dried leaves of the three plants were powdered mechanically and extracted with ethyl acetate, acetone and methanol. One gram of crude extract was first dissolved in 100 ml of acetone (stock solution). From the stock solution, test solution concentrations of 31.21- 499.42 mg/l for oviposition- deterrence assay and repellency and 15.60 - 998.85 mg/l were used in ovicidal assay. The percentage oviposition- deterrence, hatching rate of eggs and protection time were calculated. One-way analysis of variance was used for the multiple concentration tests and for per cent mortality to determine significant treatment differences. Results: The percentage of effective oviposition repellency was highest at 499.42 mg/l and the lowest at 31.21 mg/l in ethyl acetate, acetone and methanol extracts of A. paniculata, E. prostrata and T. erecta. The oviposition activity index (OAI) value of ethyl acetate, acetone and methanol extracts of A. paniculata, E. prostrata and T. erecta at 499.42 mg/l were -0.91, -0.93, -0.84, -0.84, -0.87, -0.82, -0.87, -0.89 and -0.87, respectively. Mortality (no egg hatchability) was 100 per cent with ethyl acetate and methanol extracts of A. paniculata, E. prostrata and T. erecta at 998.85 mg/l. The maximum adult repellent activity was observed at 499.42 mg/l in ethyl acetate extracts of A. paniculata, E. prostrata and methanol extracts of T. erecta, and the mean complete protection time ranged from 120 to 150 min with the different extracts tested. Interpretation & conclusions: The acetone extract of A. paniculata, methanol extract of E. prostrata and T. erecta showed good oviposition-deterrent, ovicidal and repellent activities respectively. These results suggest that the leaf extracts of A. paniculata, E. prostrata and T. erecta may have the potential to be used as an ideal eco-friendly approach for the control of the An. subpictus. PMID:21985822

Identifying the effective concentration for spatial repellency of the dengue vector Aedes aegypti

PubMed Central

2012-01-01

Background Current efforts are underway to quantify the chemical concentration in a treated air space that elicits a spatial repellent (deterrent) response in a vector population. Such information will facilitate identifying the optimum active ingredient (AI) dosage and intervention coverage important for the development of spatial repellent tools – one of several novel strategies being evaluated for vector-borne disease control. This study reports initial findings from air sampling experiments conducted under field conditions to describe the relationship between air concentrations of repellent AIs and deterrent behavior in the dengue vector, Aedes aegypti. Methods Air samples were taken inside and outdoors of experimental huts located in Pu Tuey Village, Kanchanaburi Province, Thailand in conjunction with mosquito behavioral evaluations. A mark-release-recapture study design using interception traps was used to measure deterrency of Ae. aegypti against 0.00625% metofluthrin coils and DDT-treated fabric (2g/m2) within separate experimental trials. Sentinel mosquito cohorts were positioned adjacent to air sampling locations to monitor knock down responses to AI within the treated air space. Air samples were analyzed using two techniques: the U.S. Environmental Protection Agency (USEPA) Compendium Method TO-10A and thermal desorption (TD). Results Both the USEPA TO-10A and TD air sampling methods were able to detect and quantify volatized AIs under field conditions. Air samples indicated concentrations of both repellent chemicals below thresholds required for toxic responses (mortality) in mosquitoes. These concentrations elicited up to a 58% and 70% reduction in Ae. aegypti entry (i.e., deterrency) into treated experimental huts using metofluthrin coils and DDT-treated fabric, respectively. Minimal knock down was observed in sentinel mosquito cohorts positioned adjacent to air sampling locations during both chemical evaluations. Conclusions This study is the first to describe two air sampling methodologies that are appropriate for detecting and quantifying repellent chemicals within a treated air space during mosquito behavior evaluations. Results demonstrate that the quantity of AI detected by the mosquito vector, Ae. aegypti, that elicits repellency is far lower than that needed for toxicity. These findings have important implications for evaluation and optimization of new vector control tools that function through mosquito behavior modification as opposed to mortality. PMID:23273133

Can We Deter Terrorists From Employing Weapons of Mass Destruction on the U.S. Homeland?

DTIC Science & Technology

2003-04-01

come to think of al Qaeda like a strawberry plant that sends out runners forming roots where they touch the ground to spawn new plants. These new plants...technicians, and Islamic charities. Individual successes at the operational and tactical level can also have a chilling effect on recruitment and...Some believe the U.S. faces its greatest WMD threat since the 1962 Cuban missile crisis, but many discount the effect deterrence can have on terrorist

Graduated driver licensing and differential deterrence: The effect of license type on intentions to violate road rules.

PubMed

Poirier, Brigitte; Blais, Etienne; Faubert, Camille

2018-01-01

In keeping with the differential deterrence theory, this article assesses the moderating effect of license type on the relationship between social control and intention to violate road rules. More precisely, the article has two objectives: (1) to assess the effect of license type on intentions to infringe road rules; and (2) to pinpoint mechanisms of social control affecting intentions to violate road rules based on one's type of driver license (a restricted license or a full license). This effect is examined among a sample of 392 young drivers in the province of Quebec, Canada. Drivers taking part in the Graduated Driver Licensing (GDL) program have limited demerit points and there is zero tolerance for drinking-and-driving. Propensity score matching techniques were used to assess the effect of the license type on intentions to violate road rules and on various mechanisms of social control. Regression analyses were then conducted to estimate the moderating effect of license type. Average treatment effects from propensity score matching analyses indicate that respondents with a restricted license have lower levels of intention to infringe road rules. While moral commitment and, to a lesser extent, the perceived risk of arrest are both negatively associated with intentions to violate road rules, the license type moderates the relationship between delinquent peers and intentions to violate road rules. The effect of delinquent peers is reduced among respondents with a restricted driver license. Finally, a diminished capability to resist peer pressure could explain the increased crash risk in months following full licensing. Copyright © 2017 Elsevier Ltd. All rights reserved.

Surgical treatment of obesity.

PubMed

Puzziferri, Nancy; Blankenship, Jeanne; Wolfe, Bruce M

2006-02-01

The surgical treatment of obesity has existed for over 50 yr. Surgical options have evolved from high-risk procedures infrequently performed, to safe, effective procedures increasingly performed. The operations used today provide significant durable weight loss, resolution or marked improvement of obesity-related comorbidities, and enhanced quality of life for the majority of patients. The effect of bariatric surgery on the neurohormonal regulation of energy homeostasis is not fully understood. Despite its effectiveness, less than 1% of obese patients are treated surgically. The perception that obesity surgery is unsafe remains a deterrent to care.

The Canadian Natural Health Products (NHP) Regulations: Industry Compliance Motivations

PubMed Central

Laeeque, Hina; Kachan, Natasha; Cohen, Jillian Clare; D'Cruz, Joseph

2007-01-01

This qualitative study explores corporations' motivations to comply with new natural health products (NHP) Regulations in Canada. Interviews were conducted with representatives from 20 Canadian NHP companies. Findings show that the rationale for compliance differs for large compared to small and medium-sized enterprises (SMEs). Large firms are motivated to comply with the regulations because of the deterrent fear of negative media coverage, social motivations, ability to comply and maintaining a competitive market advantage. In contrast, SMEs are motivated to comply due to the deterrent fear of legal prosecution and a sense of duty. PMID:17549245

An overview of the potential threat as related to missile requirements

NASA Technical Reports Server (NTRS)

Spearman, M. L.

1983-01-01

Based on unclassified sources, a general review is presented of the perceived U.S.S.R. doctrine, force balances, production ratios, inventory growth, inventory items, and current actions. The extent to which the Soviets appear to be attempting to increase their sphere of influence through economic and political control as well as possible military control of land, sea, air, and space is considered. To offset such possibilities, certain areas of deterrent needs that the Western world might pursue are suggested. Particular emphasis is placed on the role of missiles as part of the deterrent needs.

Antifeedant activity of xanthohumol and supercritical carbon dioxide extract of spent hops against stored product pests.

PubMed

Jackowski, J; Hurej, M; Rój, E; Popłoński, J; Kośny, L; Huszcza, E

2015-08-01

Xanthohumol, a prenylated flavonoid from hops, and a supercritical carbon dioxide extract of spent hops were studied for their antifeedant activity against stored product insect pests: Sitophilus granarius L., Tribolium confusum Duv. and Trogoderma granarium Everts. Xanthohumol exhibited medium deterrent activity against the adults of S. granarius L. and larvae of T. confusum Duv. The spent hops extract was more active than xanthohumol towards the adults of T. confusum Duv. The potential application of the crude spent hops extract as a feeding deterrent against the stored product pests is proposed.

The Canadian Natural Health Products (NHP) regulations: industry compliance motivations.

PubMed

Laeeque, Hina; Boon, Heather; Kachan, Natasha; Cohen, Jillian Clare; D'Cruz, Joseph

2007-06-01

This qualitative study explores corporations' motivations to comply with new natural health products (NHP) Regulations in Canada. Interviews were conducted with representatives from 20 Canadian NHP companies. Findings show that the rationale for compliance differs for large compared to small and medium-sized enterprises (SMEs). Large firms are motivated to comply with the regulations because of the deterrent fear of negative media coverage, social motivations, ability to comply and maintaining a competitive market advantage. In contrast, SMEs are motivated to comply due to the deterrent fear of legal prosecution and a sense of duty.

Refugee blues: a UK and European perspective

PubMed Central

Turner, Stuart

2015-01-01

In this paper, the numbers of refugees travelling to the European Union are set in a global context. It is argued that the increasing restrictions placed on asylum seekers from the 1980s onwards in the UK and the associated culture of deterrence and prohibition have had the perverse effect of supporting the economic market for people smuggling. It appears that these restrictions were initially designed to deter people, most of whom would have been granted humanitarian assistance had they managed to arrive in the UK, so as to prevent them from accessing the decision-making process on asylum. Policy changes concerning travel, benefits, and other pressures on asylum seekers are also considered in the context of deterrence. The problems facing asylum seekers do not end with their arrival in a safe country. The current methods of determining refugee status are alarmingly weak. Indeed there is evidence suggesting that those who are most traumatised before arrival face systematic disadvantage. The focus of this paper is on the United Kingdom but its conclusions apply to most Western European countries. The paper concludes with some tentative suggestions for change. PMID:26514159

Racial disparity and the legitimacy of the criminal justice system: exploring consequences for deterrence.

PubMed

Taxman, Faye S; Byrne, James M; Pattavina, April

2005-11-01

Minority (over) representation in the criminal justice system remains a puzzle, both from a policy and an intervention perspective. Cross-sectional reviews of the policies and practices of the criminal justice system often find differential rates of involvement in the criminal justice system that are associated with the nature of the criminal charge/act or characteristics of the offender; however, longitudinal reviews of the race effect often show it to be confounded by procedural and extralegal variables. This review focuses on how the cumulative policies and practices of the criminal justice system contribute to churning, or the recycling of individuals through the system. In conducting our review, we describe how the same criminal justice processes and practices adversely affect select communities. The consequences of policies and procedures that contribute to churning may affect the legitimacy of the criminal justice system as a deterrent to criminal behavior. A research agenda on issues related to legitimacy of the criminal justice system aimed at a better understanding of how this affects individual and community behavior is presented.

Examining the Direct and Indirect Effects of Fear and Anger on Criminal Decision Making Among Known Offenders.

PubMed

Bouffard, Jeff A

2015-12-01

Deterrence represents the central theoretical core of the American criminal justice system, yet relatively little attention has been paid to how emotions like fear and anger may relate to deterrence. Psychological research has debated whether negative emotions each have similar impacts on decision making (valence approaches) or if distinct emotions have unique impacts (appraisal tendency approaches). This study explores the direct and indirect influences of fear and anger on hypothetical drunk driving likelihood, including their impact on cost perceptions. Surveys were administered to 1,013 male and female incarcerated felony offenders in the Southwestern United States. Using a multivariate path model and controlling for a number of other individual factors, current fear related to increased cost perceptions and anger to decreased costs. Anger also maintained a direct influence on drunk driving, whereas fear did not. Despite their shared negative valence, fear and anger appear to have dissimilar influences on cost perceptions and criminal decision making. A better understanding of these processes may lead to improved crime prevention approaches. © The Author(s) 2014.

A Deterrence Approach to Regulate Nurses' Compliance with Electronic Medical Records Privacy Policy.

PubMed

Kuo, Kuang-Ming; Talley, Paul C; Hung, Ming-Chien; Chen, Yen-Liang

2017-11-03

Hospitals have become increasingly aware that electronic medical records (EMR) may bring about tangible/intangible benefits to managing institutions, including reduced medical errors, improved quality-of-care, curtailed costs, and allowed access to patient information by healthcare professionals regardless of limitations. However, increased dependence on EMR has led to a corresponding increase in the influence of EMR breaches. Such incursions, which have been significantly facilitated by the introduction of mobile devices for accessing EMR, may induce tangible/intangible damage to both hospitals and concerned individuals. The purpose of this study was to explore factors which may tend to inhibit nurses' intentions to violate privacy policy concerning EMR based upon the deterrence theory perspective. Utilizing survey methodology, 262 responses were analyzed via structural equation modeling. Results revealed that punishment certainty, detection certainty, and subjective norm would most certainly and significantly reduce nurses' intentions to violate established EMR privacy policy. With these findings, recommendations for health administrators in planning and designing effective strategies which may potentially inhibit nurses from violating EMR privacy policy are discussed.

Ink from longfin inshore squid, Doryteuthis pealeii, as a chemical and visual defense against two predatory fishes, summer flounder, Paralichthys dentatus, and sea catfish, Ariopsis felis.

PubMed

Derby, Charles D; Tottempudi, Mihika; Love-Chezem, Tiffany; Wolfe, Lanna S

2013-12-01

Chemical and visual defenses are used by many organisms to avoid being approached or eaten by predators. An example is inking molluscs-including gastropods such as sea hares and cephalopods such as squid, cuttlefish, and octopus-which release a colored ink upon approach or attack. Previous work showed that ink can protect molluscs through a combination of chemical, visual, and other effects. In this study, we examined the effects of ink from longfin inshore squid, Doryteuthis pealeii, on the behavior of two species of predatory fishes, summer flounder, Paralichthys dentatus, and sea catfish, Ariopsis felis. Using a cloud assay, we found that ink from longfin inshore squid affected the approach phase of predation by summer flounder, primarily through its visual effects. Using a food assay, we found that the ink affected the consummatory and ingestive phase of predation of both sea catfish and summer flounder, through the ink's chemical properties. Fractionation of ink showed that most of its deterrent chemical activity is associated with melanin granules, suggesting that either compounds adhering to these granules or melanin itself are the most biologically active. This work provides the basis for a comparative approach to identify deterrent molecules from inking cephalopods and to examine neural mechanisms whereby these chemicals affect behavior of fish, using the sea catfish as a chemosensory model.

'Lowering the threshold of effective deterrence'-Testing the effect of private security agents in public spaces on crime: A randomized controlled trial in a mass transit system.

PubMed

Ariel, Barak; Bland, Matthew; Sutherland, Alex

2017-01-01

Supplementing local police forces is a burgeoning multibillion-dollar private security industry. Millions of formal surveillance agents in public settings are tasked to act as preventative guardians, as their high visibility presence is hypothesized to create a deterrent threat to potential offenders. Yet, rigorous evidence is lacking. We randomly assigned all train stations in the South West of England that experienced crime into treatment and controls conditions over a six-month period. Treatment consisted of directed patrol by uniformed, unarmed security agents. Hand-held trackers on every agent yielded precise measurements of all patrol time in the stations. Count-based regression models, estimated marginal means and odds-ratios are used to assess the effect of these patrols on crimes reported to the police by victims, as well as new crimes detected by police officers. Outcomes are measured at both specified target locations to which security guards were instructed to attend, as well as at the entire station complexes. Analyses show that 41% more patrol visits and 29% more minutes spent by security agents at treatment compared to control stations led to a significant 16% reduction in victim-generated crimes at the entirety of the stations' complexes, with a 49% increase in police-generated detections at the target locations. The findings illustrate the efficacy of private policing for crime prevention theory.

Spatial variability in secondary metabolites of the indo-pacific sponge Stylissa massa.

PubMed

Rohde, Sven; Gochfeld, Deborah J; Ankisetty, Sridevi; Avula, Bharathi; Schupp, Peter J; Slattery, Marc

2012-05-01

Chemical diversity represents a measure of selective pressures acting on genotypic variability. In order to understand patterns of chemical ecology and biodiversity in the environment, it is necessary to enhance our knowledge of chemical diversity within and among species. Many sponges produce variable levels of secondary metabolites in response to diverse biotic and abiotic environmental factors. This study evaluated intra-specific variability in secondary metabolites in the common Indo-Pacific sponge Stylissa massa over various geographic scales, from local to ocean basin. Several major metabolites were quantified in extracts from sponges collected in American Samoa, Pohnpei, Saipan, and at several sites and depths in Guam. Concentrations of several of these metabolites varied geographically across the Pacific basin, with American Samoa and Pohnpei exhibiting the greatest differences, and Guam and Saipan more similar to each other. There were also significant differences in concentrations among different sites and depths within Guam. The crude extract of S. massa exhibited feeding deterrence against the omnivorous pufferfish Canthigaster solandri at natural concentrations, however, none of the isolated compounds was deterrent at the maximum natural concentrations observed, nor were mixtures of these compounds, thus emphasizing the need for bioassay-guided isolation to characterize specific chemical defenses. Antibacterial activity against a panel of ecologically relevant pathogens was minimal. Depth transplants, predator exclusion, and UV protection experiments were performed, but although temporal variability in compound concentrations was observed, there was no evidence that secondary metabolite concentration in S. massa was induced by any of these factors. Although the reasons behind the variability observed in the chemical constituents of S. massa are still in question, all sponges are not created equal from a chemical standpoint, and these studies provide further insights into patterns of chemical diversity within S. massa.

An Analysis of Internal Controls and Procurement Fraud Deterrence

DTIC Science & Technology

2013-12-01

might keep the organization from achieving its objectives and analyze risks , including fraud risk , so as to decide how the risk should be managed ( COSO ...internal control to adequately manage the risk ( COSO , 2013). Risk management involves developing the effective internal control targeted at a...structure and management . While the risk of fraud cannot be eliminated entirely, it can be greatly reduced with an appropriate procurement fraud prevention

Prenuclear-age leaders and the nuclear arms race.

PubMed

Frank, Jerome D

1982-10-01

Nuclear arms are a phenomenon with no historical precedent, yet people--and their national leaders--confront the prospect of nuclear war with psychological attitudes from an earlier, simpler time. This paper considers the meaning of our image of the "enemy," analyzes the appropriateness and effectiveness of a policy of deterrence, and considers approaches to doing away with war and to easing international antagonisms through the pursuit of mutually beneficial goals.

Report of the Defense Science Board Task Force on Nuclear Deterrence Skills

DTIC Science & Technology

2008-09-01

entail modeling and simulation capability analogous to that for weapon design. A minimum “national” nuclear weapons effects simulator enterprise...systems programs (design, develop, produce, deploy, and sustain) relies 18 I C HA P TE R 3 upon a variety of management models . For example, the Air...entry vehicle design, modeling and simulation efforts, command and control, launch system infrastructure, intermediate-range missile concepts, advanced

How DARHT Works - the World's Most Powerful X-ray Machine

ScienceCinema

None

2018-06-01

The Dual Axis Radiographic Hydrodynamic Test (DARHT) facility at Los Alamos National Laboratory is an essential scientific tool that supports Stockpile Stewardship at the Laboratory. The World's most powerful x-ray machine, it's used to take high-speed images of mock nuclear devices - data that is used to confirm and modify advanced computer codes in assuring the safety, security, and effectiveness of the U.S. nuclear deterrent.

Nuclear Deterrence: Strong Policy is Needed for Effective Defense

DTIC Science & Technology

2011-03-24

providing anti-access to U.S. forces should conflict erupt, for example over the Taiwan sovereignty issue.29 Emerging Chinese long- range delivery systems...securing fissile material is already extremely difficult. It is quite possible that some nuclear material is unaccounted for in the world; even if banned ...Nuclear weapons are like very complicated chemical experiments, sometimes changing in unforeseen ways as metals corrode, plastics break down and

AMERICA’S BASE NETWORK: CREDIBLE DETERRENCE

DTIC Science & Technology

2017-04-06

reduction occurring after World War I.13 Both eras saw decades of instability and warfare replace the economic stability provided by the US and its global...is still in effect today and is based on shared interests in security and stability . The alliance was formally established via an Economic and...Abstract This essay looks at historical US basing strategy in order to understand the geopolitical and economic complexity facing diplomacy of future

Could plant extracts have enabled hominins to acquire honey before the control of fire?

PubMed

Kraft, Thomas S; Venkataraman, Vivek V

2015-08-01

Honey is increasingly recognized as an important food item in human evolution, but it remains unclear whether extinct hominins could have overcome the formidable collective stinging defenses of honey bees during honey acquisition. The utility of smoke for this purpose is widely recognized, but little research has explored alternative methods of sting deterrence such as the use of plant secondary compounds. To consider whether hominins could have used plant extracts as a precursor or alternative to smoke, we review the ethnographic, ethnobotanical, and plant chemical ecology literature to examine how humans use plants in combination with, and independently of, smoke during honey collection. Plant secondary compounds are diverse in their physiological and behavioral effects on bees and differ fundamentally from those of smoke. Plants containing these chemicals are widespread and prove to be remarkably effective in facilitating honey collection by honey hunters and beekeepers worldwide. While smoke may be superior as a deterrent to bees, plant extracts represent a plausible precursor or alternative to the use of smoke during honey collection by hominins. Smoke is a sufficient but not necessary condition for acquiring honey in amounts exceeding those typically obtained by chimpanzees, suggesting that significant honey consumption could have predated the control of fire. Copyright © 2015 Elsevier Ltd. All rights reserved.

REDUCTIONS WITHOUT REGRET: DEFINING THE NEEDED CAPABILITIES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Swegle, J.; Tincher, D.

This is the second of three papers (in addition to an introductory summary) aimed at providing a framework for evaluating future reductions or modifications of the U.S. nuclear force, first by considering previous instances in which nuclear-force capabilities were eliminated; second by looking forward into at least the foreseeable future at the features of global and regional deterrence (recognizing that new weapon systems currently projected will have expected lifetimes stretching beyond our ability to predict the future); and third by providing examples of past or possible undesirable outcomes in the shaping of the future nuclear force, as well as somemore » closing thoughts for the future. This paper begins with a discussion of the current nuclear force and the plans and procurement programs for the modernization of that force. Current weapon systems and warheads were conceived and built decades ago, and procurement programs have begun for the modernization or replacement of major elements of the nuclear force: the heavy bomber, the air-launched cruise missile, the ICBMs, and the ballistic-missile submarines. In addition, the Nuclear Weapons Council has approved a new framework for nuclear-warhead life extension not fully fleshed out yet that aims to reduce the current number of nuclear explosives from seven to five, the so-called 3+2 vision. This vision includes three interoperable warheads for both ICBMs and SLBMs (thus eliminating one backup weapon) and two warheads for aircraft delivery (one gravity bomb and one cruise-missile, eliminating a second backup gravity bomb). This paper also includes a discussion of the current and near-term nuclear-deterrence mission, both global and regional, and offers some observations on future of the strategic deterrence mission and the challenges of regional and extended nuclear deterrence.« less

Biting deterrence and insecticidal activity of hydrazide-hydrazones and their corresponding 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazoles against Aedes aegypti.

PubMed

Tabanca, Nurhayat; Ali, Abbas; Bernier, Ulrich R; Khan, Ikhlas A; Kocyigit-Kaymakcioglu, Bedia; Oruç-Emre, Emine E; Unsalan, Seda; Rollas, Sevim

2013-06-01

Taking into account the improvement in insecticidal activity by the inclusion of fluorine in the hydrazone moiety, the authors synthesized new 4-fluorobenzoic acid hydrazides and 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazoles, substituting a phenyl group or a heteroaryl ring carrying one or two atoms of F, Cl and Br, and investigated their biting deterrent and larvicidal activities against Aedes aegypti for the first time. The compound 3-acetyl-5-(4-fluorophenyl)-2-[4-(dimethylamino)phenyl]-2,3-dihydro-1,3,4-oxadiazole (17) produced the highest biting deterrent activity (BDI = 1.025) against Ae. Aegypti, followed by 4-fluorobenzoic acid [(phenyl)methylene] hydrazide (1). These activity results were similar to those of N,N-diethyl-meta-toluamide (DEET), which showed a proportion not biting of 0.8-0.92. When compounds 1 and 17 were tested on cloth worn on human volunteers, compound 1 was not repellent for some volunteers until present in excess of 500 nmol cm(-2) , while compound 17 was not repellent at the highest concentration tested (1685 nmol cm(-2) ). In the larvicidal screening bioassays, only compounds 10, 11, 12 and 17 showed 100% mortality at the highest screening dose of 100 ppm against Ae. aegypti larvae. Compounds 11 and 12 with LD50 values of 24.1 and 30.9 ppm showed significantly higher mortality than 10 (80.3 ppm) and 17 (58.7 ppm) at 24-h post-treatment. The insecticidal and biting deterrent activities were correlated with the presence of a halogen atom on the phenyl or heteroaryl substituent of the hydrazone moiety. © 2012 Society of Chemical Industry.

Strategic Missile Defense & Nuclear Deterrence

NASA Astrophysics Data System (ADS)

Grego, Laura

The United States has pursued defenses against nuclear-armed long-range ballistic missiles since at least the 1950s. At the same time, concerns that missile defenses could undermine nuclear deterrence and potentially spark an arms race led the United States and Soviet Union to negotiate limits on these systems. The 1972 Anti-Ballistic Missile Treaty constrained strategic missile defenses for thirty years. After abandoning the treaty in 2002, President George W. Bush began fielding the Ground-based Midcourse Defense (GMD) homeland missile defense system on an extremely aggressive schedule, nominally to respond to threats from North Korea and Iran. Today, nearly fifteen years after its initial deployment, the potential and the limits of this homeland missile defense are apparent. Its test record is poor and it has no demonstrated ability to stop an incoming missile under real-world conditions. No credible strategy is in place to solve the issue of discriminating countermeasures. Insufficient oversight has not only exacerbated the GMD system's problems, but has obscured their full extent, which could encourage politicians and military leaders to make decisions that actually increase the risk of a missile attack against the United States. These are not the only costs. Both Russia and China have repeatedly expressed concerns that U.S. missile defenses adversely affect their own strategic capabilities and interests, particularly taken in light of the substantial US nuclear forces. This in turn affects these countries' nuclear modernization priorities. This talk will provide a technical overview of the US strategic missile defense system, and how it relates to deterrence against non-peer adversaries as well as how it affects deterrence with Russia and China and the long-term prospects for nuclear reductions

The role of opacity and transparency in achieving strategic stability in South Asia.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rajain, Arpit; Ashraf, Tariq Mahmud

According to international relations theory, deterrence can be used as a tool to achieve stability between potentially hostile nations. India and Pakistan's long history of periodic crises raises the question of how they can achieve deterrence stability. 'Transparency' describes the flow of information between parties and plays a key role in establishing a deterrence relationship. This paper studies the balance needed between opacity and transparency in nuclear topics for the maintenance of deterrence stability between India and Pakistan. States with nuclear weapons are postulated to implement transparency in four categories: potential, capability, intent, and resolve. The study applies these categoriesmore » to the nuclear components of the ongoing India-Pakistan Composite Dialogue Working Group for Peace and Security including CBMs. To focus our efforts, we defined four scenarios to characterize representative strategic/military/political conditions. The scenarios are combinations of these two sets of opposite poles: competition - cooperation; extremism - moderation (to be understood primarily in a religious/nationalistic sense). We describe each scenario in terms of select focal areas (nuclear doctrine, nuclear command and control, nuclear stockpile, nuclear delivery/defensive systems, and conventional force posture). The scenarios help frame the realm of possibilities, and have been described in terms of expected conditions for the focal areas. We then use the conditions in each scenario to prescribe a range of information-sharing actions that the two countries could take to increase stability. We also highlight the information that should not be shared. These actions can be political (e.g., declarations), procedural (e.g., advance notice of certain military activities), or technologically based (e.g., seismic monitoring of the nuclear test moratorium).« less

Six-month, open-label study of hydrocodone extended release formulated with abuse-deterrence technology: Safety, maintenance of analgesia, and abuse potential.

PubMed

Hale, Martin E; Ma, Yuju; Malamut, Richard

2016-01-01

To evaluate long-term safety, maintenance of analgesia, and aberrant drug-related behaviors of hydrocodone extended release (ER) formulated with CIMA® Abuse-Deterrence Technology. Phase 3, multicenter, open-label extension. Fifty-six US centers. Adults with chronic low back pain completing a 12-week placebocontrolled study of abuse-deterrent hydrocodone ER were eligible. One hundred eighty-two patients enrolled and received ≥1 dose of study drug, 170 entered openlabel treatment, and 136 completed the study. Patients receiving hydrocodone ER in the 12-week, placebo-controlled study continued their previous dose unless adjustment was needed; those previously receiving placebo (n=78) underwent dose titration/adjustment to an analgesic dose (15-90 mg every 12 hours). Patients received 22 weeks of open-label treatment. adverse events (AEs). Maintenance of analgesia: worst pain intensity (WPI) and average pain intensity (API) at each study visit. Aberrant drug behavior: study drug loss and diversion. AEs were reported for 65/182 (36 percent) patients during dose titration/ adjustment and 88/170 (52 percent) during open-label treatment. No treatmentrelated serious AEs were reported. There were no clinically meaningful trends in other safety assessments, including physical examinations and pure tone audiometry. One patient receiving hydrocodone ER 30 mg twice daily experienced a severe AE of neurosensory deafness that was considered treatment related. Mean WPI and API remained steady throughout open-label treatment. Six (3 percent) patients reported medication loss, and 5 (3 percent) reported diversion. Abuse-deterrent hydrocodone ER was generally well tolerated in patients with chronic low back pain, maintained efficacy, and was associated with low rates of loss and diversion.

The introduction of a potentially abuse deterrent oxycodone formulation: Early findings from the Australian National Opioid Medications Abuse Deterrence (NOMAD) study.

PubMed

Degenhardt, Louisa; Bruno, Raimondo; Ali, Robert; Lintzeris, Nicholas; Farrell, Michael; Larance, Briony

2015-06-01

There is increasing concern about tampering of pharmaceutical opioids. We describe early findings from an Australian study examining the potential impact of the April 2014 introduction of an abuse-deterrent sustained-release oxycodone formulation (Reformulated OxyContin(®)). Data on pharmaceutical opioid sales; drug use by people who inject drugs regularly (PWID); client visits to the Sydney Medically Supervised Injecting Centre (MSIC); and last drug injected by clients of inner-Sydney needle-syringe programmes (NSPs) were obtained, 2009-2014. A cohort of n=606 people tampering with pharmaceutical opioids was formed pre-April 2014, and followed up May-August 2014. There were declines in pharmacy sales of 80mg OxyContin(®) post-introduction of the reformulated product, the dose most commonly diverted and injected by PWID. Reformulated OxyContin(®) was among the least commonly used and injected drugs among PWID. This was supported by Sydney NSP data. There was a dramatic reduction in MSIC visits for injection of OxyContin(®) post-introduction of the new formulation (from 62% of monthly visits pre-introduction to 5% of visits, August 2014). The NOMAD cohort confirmed a reduction in OxyContin(®) use/injection post-introduction. Reformulated OxyContin(®) was cheaper and less attractive for tampering than Original OxyContin(®). These data suggest that, in the short term, introduction of an abuse-deterrent formulation of OxyContin(®) in Australia was associated with a reduction in injection of OxyContin(®), with no clear switch to other drugs. Reformulated OxyContin(®), in this short follow-up, does not appear to be considered as attractive for tampering. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Crop Damage by Primates: Quantifying the Key Parameters of Crop-Raiding Events

PubMed Central

Wallace, Graham E.; Hill, Catherine M.

2012-01-01

Human-wildlife conflict often arises from crop-raiding, and insights regarding which aspects of raiding events determine crop loss are essential when developing and evaluating deterrents. However, because accounts of crop-raiding behaviour are frequently indirect, these parameters are rarely quantified or explicitly linked to crop damage. Using systematic observations of the behaviour of non-human primates on farms in western Uganda, this research identifies number of individuals raiding and duration of raid as the primary parameters determining crop loss. Secondary factors include distance travelled onto farm, age composition of the raiding group, and whether raids are in series. Regression models accounted for greater proportions of variation in crop loss when increasingly crop and species specific. Parameter values varied across primate species, probably reflecting differences in raiding tactics or perceptions of risk, and thereby providing indices of how comfortable primates are on-farm. Median raiding-group sizes were markedly smaller than the typical sizes of social groups. The research suggests that key parameters of raiding events can be used to measure the behavioural impacts of deterrents to raiding. Furthermore, farmers will benefit most from methods that discourage raiding by multiple individuals, reduce the size of raiding groups, or decrease the amount of time primates are on-farm. This study demonstrates the importance of directly relating crop loss to the parameters of raiding events, using systematic observations of the behaviour of multiple primate species. PMID:23056378

Investigation on deterrence effect of legal punishment measures on driving after drinking in Chongqing, China.

PubMed

Suo, Qinghui

2015-01-01

Driving after drinking is one of the main causes associated with road accidents in China. China has been concerned about this serious problem and updated the regulations of road traffic safety law about driving after drinking 3 times in the last 10 years to deter this offense. The deterrence effect of the current punishment measures implemented since January 2013 was studied in this article. Data applied in the study were collected by questionnaire surveys carried out in Chongqing, a city in southwest China. A total of 329 drivers participated in 3 rounds of the survey and a 5-point scale rating was applied in the investigation. There was a slight difference between drivers' familiarity of the law regarding driving after drinking in April 2013 and April 2014. The perceived certainty of being caught for driving after drinking was higher in April 2013 than in April 2014 and it had a time-dependent decreasing tendency. Our investigations also show that license suspension is the most practical and effective measure and penalty points system ranks second. A monetary fine appears to be inefficient to achieve the desired effects. The fourth edition of the Road Traffic Safety Law of the People's Republic of China, which took effect in January 2013 coinciding with the application of random breath testing and intensification of enforcement activity, is effective in deterring driving after drinking according to our investigation. More measures should be implemented to change the decreasing tendency of perceived certainty of being caught for driving after drinking. An increase in the monetary fine is suggested.

The impact of child welfare legislation on domestic violence-related homicide rates.

PubMed

Dasgupta, Kabir; Pacheco, Gail

2018-05-01

State-specific statutes providing legal consequences for perpetrating domestic violence in the presence of a child have been enacted across the United States between 1996 and 2012. This paper examines the impact of this child welfare legislation, using a difference-in-differences approach. We find a significant drop in domestic violence-related homicide rates, when considering a wide range of victim-offender relationships. However, this result does not hold for marital homicides, suggesting that for this subpopulation, the risk of reprisal and consequent reduction in reporting may be counterbalancing the hypothesized deterrent impacts of the legislation. Copyright © 2018 John Wiley & Sons, Ltd.

Insect Feeding Deterrents in Endophyte-Infected Tall Fescue †

PubMed Central

Johnson, M. C.; Dahlman, D. L.; Siegel, M. R.; Bush, L. P.; Latch, G. C. M.; Potter, D. A.; Varney, D. R.

1985-01-01

The presence of an endophytic fungus, Acremonium coenophialum, in tall fescue (Festuca arundinacea) deterred aphid feeding by Rhopalosiphum padi and Schizaphis graminum. Both species of aphid were unable to survive when confined to endophyte-infected tall fescue plants. Feeding deterrents and toxic factors to R. padi and Oncopeltus fasciatus, large milkweed bug, were primarily associated with a methanol extract obtained when endophyte-infected tall fescue seed was serially extracted with hexane, ethyl acetate, and methanol. The concentrations of pyrrolizidine alkaloids were determined to be 30 to 100 times greater in the methanol extract than in the hexane and ethyl acetate extracts. PMID:16346751

An overview of aerodynamic research and technology requirements as related to some military needs

NASA Technical Reports Server (NTRS)

Spearman, M. L.

1983-01-01

Based on unclassified sources, a general review is presented of some military needs in light of the perceived U.S.S.R. doctrine, force balances, inventory growth, inventory items, and current actions. The Soviets appear to be attempting to increase their sphere of influence throught economic and political control as well as possible military control of land, sea, air, and space. To offset such possibilities, certain areas of deterrent needs that the Western World might pursue are suggested. Particular emphasis is placed on the role of research and technology related to aerospace systems as part of the deterrent needs.

Development concept for a small, split-core, heat-pipe-cooled nuclear reactor

NASA Technical Reports Server (NTRS)

Lantz, E.; Breitwieser, R.; Niederauer, G. F.

1974-01-01

There have been two main deterrents to the development of semiportable nuclear reactors. One is the high development costs; the other is the inability to satisfy with assurance the questions of operational safety. This report shows how a split-core, heat-pipe cooled reactor could conceptually eliminate these deterrents, and examines and summarizes recent work on split-core, heat-pipe reactors. A concept for a small reactor that could be developed at a comparatively low cost is presented. The concept would extend the technology of subcritical radioisotope thermoelectric generators using 238 PuO2 to the evolution of critical space power reactors using 239 PuO2.

Potential feeding deterrents found in hemlock woolly adelgid, Adelges tsugae

NASA Astrophysics Data System (ADS)

Jones, Anne C.; Mullins, Donald E.; Jones, Tappey H.; Salom, Scott M.

2012-07-01

The nonnative hemlock woolly adelgid ( Adelges tsugae Annand, Hemiptera: Sternorrhyncha: Adelgidae) has been a significant mortality agent of eastern hemlock ( Tsuga canadensis Carriere) throughout a large portion of its geographic range. During a study investigating adelgid vigor in relation to host health, it was noted that adelgid extracts ranged from a yellow to a deep red color. Analysis by GC-MS identified the presence of the anthraquinone, chrysophanol and its anthrone precursor, chrysarobin in the extract. These compounds are predator deterrents in several other insects, including chrysomelid beetles. It is hypothesized that these compounds serve a similar purpose in the hemlock woolly adelgid.

West European and East Asian Perspectives on Defense, Deterrence and Strategy. Volume 2. Western European Perspectives on Defense, Deterrence and Strategy.

DTIC Science & Technology

1984-05-16

3a - vDE Or 4EPORT 13b 󈨋M COvERED :W)AE OF REPOR~ r or ay 5~ COu.N. *Technical :ROM 821201 -o 8451" 1984, May 16"a 238" 0y 5-I o. * 6 Su POLEMETARY...34 International Defense Review, Vol. 12, No. 3 (1979). 82. Geneste, Colonel Marc. ’La Bataille Terrestre Nuc1~aire,5 Strategie, (July-September 1976). 83.t, u...Strategi- gues, Nucl~aires Tactiques, Terrestres Maritimes et Aeriennes,’ Le Figaro, April 21, 1983. 182. Everts, Philip P. ’Reviving Unilateralism

Nitrogenous ovipositional deterrents in the leaves of sweet pepper (Capsicum annuum) at the mature stage against the leafminer, Liriomyza trifolii (Burgess).

PubMed

Dekebo, Aman; Kashiwagi, Takehiro; Tebayashi, Shin-ich; Kim, Chul-Sa

2007-02-01

Mature leaves of the sweet pepper, Capsicum annuum, exhibited resistance against the American serpentine leafminer, Liriomyza trifolii (Burgess), Agromyzidae. Based on bioassay-guided fractionation, three compounds, namely 4-aminobutanoic acid, (2S,4R)-4-hydroxy-1-methyl-2-pyrrolidine carboxylic acid and 4-amino-1-beta-D-ribofuranosyl-2(1H)-pyrimidinone, were isolated from the leaves of sweet pepper. These compounds had significant oviposition deterrence towards adult flies of L. trifolii from laying their eggs on host plant leaves treated at 3.70, 16.60 and 6.45 microg/cm(2), respectively.

Assessing the Impact of a Focused Deterrence Strategy to Combat Intimate Partner Domestic Violence.

PubMed

Sechrist, Stacy M; Weil, John D

2018-03-01

The Offender Focused Domestic Violence Initiative (OFDVI) represents for the first time anywhere the application of the evidence-based focused deterrence policing approach to combat intimate partner domestic violence (IPDV). Through holding offenders accountable, the strategy has resulted in 20% reductions each in IPDV-related calls for police service and arrests. Victim injuries have been significantly reduced and the 1-year IPDV offender recidivism rate is about 16-17%. The backbone of the OFDVI strategy is the multidisciplinary collaboration of law enforcement and community partners which has resulted in identification and resolving system issues which have historically allowed offenders to repeat IPDV without consequence.

Association between alcoholism and the dopamine D4 receptor gene.

PubMed Central

Muramatsu, T; Higuchi, S; Murayama, M; Matsushita, S; Hayashida, M

1996-01-01

A point mutation in the aldehyde dehydrogenase 2 gene (ALDH2(2) allele) is considered to be a genetic deterrent for alcoholism; however, 80 of 655 Japanese alcoholics had the mutant allele. Genotype factors that might increase susceptibility by overriding the deterrent showed a higher frequency of a five repeat allele of the dopamine D4 receptor 48 bp repeat polymorphism in alcoholics with ALDH2(2) than in 100 other alcoholics and 144 controls. Alcoholics with the five repeat allele also abused other drugs more often. These data suggest the involvement of the dopamine system in the development of alcoholism and other addictive behaviour. PMID:8929946

Insecticidal and Repellent Activity of Several Plant-Derived Essential Oils Against Aedes aegypti.

PubMed

Castillo, Ruth M; Stashenko, Elena; Duque, Jonny E

2017-03-01

We examined the pupicidal, adulticidal, repellent, and oviposition-deterrent activities of essential oils (EOs) from Lippia alba, L. origanoides, Eucalyptus citriodora, Cymbopogon citratus, Cymbopogon flexuosus, Citrus sinensis , Cananga odorata , Swinglea glutinosa, and Tagetes lucida plants against Aedes aegypti under laboratory conditions. Pupicidal and adulticidal activities were assessed at exploratory concentrations of 250, 310, and 390 parts per million (ppm); and 30, 300, and 1,000 ppm, respectively. The greatest pupicidal activity was exhibited at 390 ppm with a 24-h exposure by L. origanoides, and 390 ppm with a 48-h exposure by Citrus sinensis . Lippia origanoides killed all adult mosquitoes at 300 ppm after 120 min of exposure. Only L. origanoides and E. citriodora EOs, applied at 1,000 ppm to human skin, produced the greatest repellency (100%) to host-seeking Ae. aegypti after 2 min of exposure; the repellency decreased between 12% and 10% after 15 min. Complete oviposition deterrence by gravid Ae. aegypti was observed for E. citriodora EOs at 200 ppm with an oviposition activity index of -1.00. These results confirm that the EOs assessed in this study have insecticidal, repellent, and oviposition-deterrent activities against the dengue vector, Ae. aegypti.

Will abuse-deterrent formulations of opioid analgesics be successful in achieving their purpose?

PubMed

Bannwarth, Bernard

2012-09-10

During the last 2 decades, there has been a dramatic increase in the use of strong opioids for chronic non-cancer pain. This increase has been accompanied by a steep increase in abuse, misuse, and both fatal and non-fatal overdoses involving prescription opioids. The situation is already alarming in the US. Prescription opioid-related harm is a complex, multifactorial issue that requires a multifaceted solution. In this respect, formulations of opioid analgesics designed to resist or deter abuse may be a useful component of a comprehensive opioid risk minimization programme. Such formulations have or are being developed. Abuse-resistant opioids include those that use some kind of physical barrier to prevent tampering with the formulation. Abuse-deterrent opioids are not necessarily resistant to tampering, but contain substances that are designed to make the formulation less attractive to abusers. This article focuses on two products intended to deter abuse that were reviewed by the US Food and Drug Administration (FDA). The first (Embeda®) consists of extended-release morphine with sequestered naltrexone, an opioid antagonist that is released if the tablet is compromised by chewing or crushing. Although Embeda® exhibited abuse-deterrent features, its label warns that it can be abused in a manner similar to other opioid agonists. Furthermore, tampering with Embeda® will result in the release of naltrexone, which may precipitate withdrawal in opioid-tolerant individuals. In March 2011, all dosage forms of Embeda® were recalled because the product failed to meet routine stability standards, and its return date to the market is currently unknown. The second product (Acurox®) was intended to be both tamper resistant and abuse deterrent. It consisted of an immediate-release oxycodone tablet with subtherapeutic niacin as an aversive agent and used a gel-forming ingredient designed to inhibit inhalation and prevent extraction of the drug for injection. The new drug application for Acurox® was rejected in 2010 by the FDA because of concerns about the potential abuse-deterrent benefits of niacin. While acknowledging that no one formulation can be expected to deter all types of opioid-abusive behaviours and no product is likely to be abuse proof in the hands of clear and determined abusers, the reductions in abuse these new products would provide may be an incremental step towards safer prescription opioids.

Benefits and Limits of Abuse-Deterrent Painkillers.

PubMed

Hendrikson, Hollie; Hanson, Karmen

2016-02-01

Abuse of opioid prescription products, meant to reduce pain, has been making headlines in recent years as a growing problem not only in rural and urban areas, but also across population groups. Policymakers looking for effective ways to reduce such abuse are employing various strategies, including setting up prescription drug monitoring programs. Another approach gaining attention involves encouraging or requiring the use of prescription drug formulas that can help deter abuse of opioid painkiller products.

Understanding the Role of Deterrence in Counterterrorism Security

DTIC Science & Technology

2009-11-01

30, No. 5, pp. 429–443. Enders, W., Sandler, T. (1993). “The Effectiveness of Anti-Terrorism Policies: Vector Autoregression Intervention Analysis ...occasional paper series . RAND occasional papers may include an informed perspective on a timely policy issue, a discussion of new research...United States safe? Are better means available for evaluating what may work or not and why? This series is designed to focus on a small set of

Miscalculated Ambiguity: The Effects of US Nuclear Declaratory Policy on Deterrence and Nonproliferation

DTIC Science & Technology

2010-06-01

Business, Sports , Entertainment and Video News. http://edition.cnn.com/2010/ US /08/27/debt.security.mullen/index.html (accessed March 23, 2011). 70...sole-purpose policy would also vastly enhance US nonproliferation efforts. This policy would increase US legitimacy as the leader of the...March 29, 2011). 93 "Iran Ridicules Obama Nuclear Policy - USATODAY.com." News, Travel, Weather, Entertainment , Sports , Technology, U.S. & World

Effects of nicotine on the digestive performance of nectar-feeding birds reflect their relative tolerance to this alkaloid.

PubMed

Lerch-Henning, S; Nicolson, S W

2015-12-01

The paradox of secondary metabolites, toxic defence compounds produced by plants, in nectar and fruits is well known. Deterrence of feeding by nectarivorous and frugivorous birds is better understood than the effect of these chemicals on the digestive performance of birds. Digestive parameters such as transit time and sugar assimilation are important in assessing nutrient utilization and deterrence may be related to post-ingestive effects involving these parameters. Nectar and many fruits contain mainly sugars and water, and avian consumers compensate for low sugar content in their diet by increasing food intake: this may also increase their intake of secondary metabolites. We investigated how the alkaloid nicotine, naturally present in nectar of Nicotiana species, influences compensatory feeding and digestive performance of nectar-feeding birds. High nicotine concentration negatively affected compensatory feeding and apparent assimilation efficiency of white-bellied sunbirds Cinnyris talatala and Cape white-eyes Zosterops virens; but nicotine slowed gut transit time only in the latter species. In contrast, food intake and digestive performance of dark-capped bulbuls Pycnonotus tricolor was unaffected by nicotine up to a concentration of 50μM. Bulbuls are primarily frugivorous; hence, they are more exposed to secondary metabolites than sunbirds and possibly white-eyes. Because their diet is richer in toxins, frugivorous birds may have evolved more efficient detoxification strategies than those of specialist nectar-feeding birds. Copyright © 2015 Elsevier Inc. All rights reserved.

West European and East Asian perspectives on defense, deterrence, and strategy. Volume 6. South Korean perspectives on defense, deterrence, and strategy. Technical report, 1 December 1981-30 November 1982

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pfaltzgraff, R.L.; Dougherty, J.E.; Davis, J.K.

1984-04-11

This study addresses the international security perspectives of the Republic of Korea (South Korea). Particular emphasis is placed on the way in which American, Soviet, Chinese and Japanese interests intersect on the Korean Peninsula and on their impact upon the military balance between North and South Korea. A major portion of this analysis is devoted as well to an examination of inter-Korean relations, spotlighting the varying security implications of the continued partition, as opposed to the eventual reunification of the two Koreas. The importance to South Korea of the Seoul-Washington-Tokyo relationship is discussed, as well as the effect of themore » Sino-Soviet dispute on South Korean defense and foreign policies. In order to clarify further the strategic perspectives of key decision makers in Seoul, the study reviewed and assessed South Korean views on such controversial issues as the expansion of Japan's self-defense forces, the withdrawal of the U.S. ground troops from the Korean peninsula, Sino-Soviet moves toward rapprochement, and the proliferation of nuclear weapons in Northeast Asia.« less

Ground squirrel tail-flag displays alter both predatory strike and ambush site selection behaviours of rattlesnakes.

PubMed

Barbour, Matthew A; Clark, Rulon W

2012-09-22

Many species approach, inspect and signal towards their predators. These behaviours are often interpreted as predator-deterrent signals--honest signals that indicate to a predator that continued hunting is likely to be futile. However, many of these putative predator-deterrent signals are given when no predator is present, and it remains unclear if and why such signals deter predators. We examined the effects of one such signal, the tail-flag display of California ground squirrels, which is frequently given both during and outside direct encounters with northern Pacific rattlesnakes. We video-recorded and quantified the ambush foraging responses of rattlesnakes to tail-flagging displays from ground squirrels. We found that tail-flagging deterred snakes from striking squirrels, most likely by advertising squirrel vigilance (i.e. readiness to dodge a snake strike). We also found that tail-flagging by adult squirrels increased the likelihood that snakes would leave their ambush site, apparently by elevating the vigilance of nearby squirrels which reduces the profitability of the ambush site. Our results provide some of the first empirical evidence of the mechanisms by which a prey display, although frequently given in the absence of a predator, may still deter predators during encounters.

U.S. Nuclear Policy, Strategy, and Force Structure: Insights and Issues from the 1994, 2001, and 2010 Nuclear Posture Reviews

DTIC Science & Technology

2014-09-01

for the different motives of proliferators.145 Joachim Krause wrote in 2007 that some members of the Clinton administration believed that they...preventing WMD use, which effectively linked deterrence to counterproliferation. 146 Joachim Krause , “Enlightenment and Nuclear Order,” International...173 Despite the concerns of some commentators, such as Daryl Kimball and Wolfgang Panofsky, Keith Payne argued that assurance was a necessary defense

High Frontier, The Journal for Space & Missile Professionals. Volume 5, Number 2

DTIC Science & Technology

2009-02-01

Institute of Space Law. He also taught management theory for Cerro Coso Com- munity College and Golden Gate University. Mr. Rendleman has been awarded the...nation must not place its sovereignty at risk or forfeit its cur- rent warfighting advantages. To present an effective deterrence, the portrait of...bombers on alert, the preponderance of reliance and risk then moves to the submarine force, essentially requiring the US to rely upon a single nuclear

High Frontier: The Journal for Space and Missile Professionals. Volume 7, Number 1, November 2010

DTIC Science & Technology

2010-11-01

effect on their decision calculus . The predictability of our response—and their accounting for it—was a part of their cost/ benefit trade space well...national leadership’s decision calculus , there is one simple point of clarity about nuclear deterrence that transcends all of the variables: your...Together with more inci- dental situations of entanglement (e.g., when services are shared on a commercial bearer), these common systems create a

Deterrence Requirements and Arms Control Responsibilities: The United State’s Obligation to Ratify the Comprehensive Nuclear Test Ban Treaty

DTIC Science & Technology

2010-02-17

systems to detect a nuclear explosion; seismic, hydroacoustic, infrasound , and radionuclide. These stations are able to detect a nuclear explosion as...These sites detect thousands of seismic events a year, mainly from earthquakes and mining explosions, and have proved effective in detecting past...that detect sound waves in the oceans, and the 60 infrasound stations above ground that detect ultra-low frequency sound waves emitted by nuclear

Computer network security for the radiology enterprise.

PubMed

Eng, J

2001-08-01

As computer networks become an integral part of the radiology practice, it is appropriate to raise concerns regarding their security. The purpose of this article is to present an overview of computer network security risks and preventive strategies as they pertain to the radiology enterprise. A number of technologies are available that provide strong deterrence against attacks on networks and networked computer systems in the radiology enterprise. While effective, these technologies must be supplemented with vigilant user and system management.

The Ring of Gyges: Anonymity and Technological Advance’s Effect on the Deterrence of Non-State Actors in 2035

DTIC Science & Technology

2011-02-16

year of 1944 (the year of highest Manhattan Project expenditures). Richard G. Hewlett and Oscar E. Anderson, Jr., The New World: A History of the...technological developments in the biological sciences may provide 39 A case in point is the Manhattan ... Project undertaken by the United States to produce the first atomic weapon. A huge national effort was required to create the first atomic weapon in

Deterrence of device counterfeiting, cloning, and subversion by substitution using hardware fingerprinting

DOEpatents

Hamlet, Jason R; Bauer, Todd M; Pierson, Lyndon G

2014-09-30

Deterrence of device subversion by substitution may be achieved by including a cryptographic fingerprint unit within a computing device for authenticating a hardware platform of the computing device. The cryptographic fingerprint unit includes a physically unclonable function ("PUF") circuit disposed in or on the hardware platform. The PUF circuit is used to generate a PUF value. A key generator is coupled to generate a private key and a public key based on the PUF value while a decryptor is coupled to receive an authentication challenge posed to the computing device and encrypted with the public key and coupled to output a response to the authentication challenge decrypted with the private key.

The bishops and nuclear weapons: The catholic pastoral letter on war and peace

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dougherty, J.E.

1984-01-01

This is a contribution to the Catholic debate over nuclear weapons, by an international relations scholar who teaches at a Catholic college. Dougherty is critical of the 1983 pastoral letter, arguing that it focuses too much on the dangers of nuclear war and the inadequacies of deterrence while giving insufficient attention to Soviet expansionism and the need for stable deterrence through a judicious mixture of military modernization and arms control. He is concerned by an increase in ''Catholic nuclear pacifism,'' fearing that the pastoral letter could become a theological rationalization for neo-isolationism in the United States. The European bishops, hemore » notes, take a more moderate view.« less

The burn surgeon: an endangered species. Can exposure in medical school increase interest in burn surgery?

PubMed

Kahn, Steven Alexander; Goldman, Matthew; Daul, Matthew; Lentz, Christopher W

2011-01-01

The nation is faced with a shortage of subspecialty physicians, including burn surgeons. Exposure to a specialty in medical school has been shown to influence students' career choices. The authors postulate that exposure to burn surgery increases their interest in the field. Students from a medical school with an American Burn Association-verified burn center and from a school without a burn center were anonymously surveyed and asked to report their interest and knowledge regarding burn surgery using a 5-point Likert scale. They were asked about their current year in school, gender, overall interest in surgery, and any prior exposure to burn surgery (eg, preceptorship or rotation). Students were asked whether exposure to burn surgery or to a strong mentor might increase their interest in the field. Finally, they were asked to pick the most important factor in a list of deterrents to pursuing a career in burn surgery. Predictors of interest in burn surgery were determined with regression analyses. A total of 380 of 662 students responded to the survey (57.4%). Significant predictors of interest in burn surgery were an interest in surgery (P < .001, odds ratio [OR] = 56.3), prior exposure to burn surgery (P = .02, OR = 5.7), and year in school (P = .006, OR = 1.7). First- and second-year students were more likely to report interest in burn surgery (P < .001). Gender and medical school attended were not significant predictors. Prior exposure to burn surgery became a stronger predictor in subgroup analysis of the fourth-year students (P < .001, OR = 24.5). The majority of students reported that exposure to burn surgery (76%) and a strong mentor (87%) would make them more likely to consider burn surgery as a career. "Not interested in surgery" was the most important deterrent to pursuing a career in burn surgery, which was selected by 33% of students. However, 25% of students chose "I don't know anything about burn surgery" as the most important deterrent. Factors specific to burn surgery were less frequently selected (eg, wound care and hot operating room). The majority of students reported ignorance of the field of burns: 64% disagreed that they understood what a burn surgeon does on a daily basis, and 74% agreed they did not know enough about the field to consider it as a career. Exposure to burn surgery in the form of a clinical rotation fosters medical student interest. However, the majority of medical students lack knowledge about the field of burn surgery. Many consider this a deterrent to selecting it as a career. More exposure during medical school and strong mentorship may influence more students to become burn surgeons. Mentorship and recruiting efforts should be focused on students with a general interest in surgery.

Reductions without Regret: Avoiding Wrong Turns, Roach Motels, and Box Canyons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Swegle, John A.; Tincher, Douglas J.

This is the third of three papers (in addition to an introductory summary) aimed at providing a framework for evaluating future reductions or modifications of the U.S. nuclear force, first by considering previous instances in which nuclear-force capabilities were eliminated; second by looking forward into at least the foreseeable future at the features of global and regional deterrence (recognizing that new weapon systems currently projected will have expected lifetimes stretching beyond our ability to predict the future); and third by providing examples of past or possible undesirable outcomes in the shaping of the future nuclear force, as well as somemore » closing thoughts for the future. In this paper, we provide one example each of our judgments on what constitutes a box canyon, a roach motel, and a wrong turn: Wrong Turn: The Reliable Replacement Warhead: Roach Motel: SRAM T vs the B61: and A Possible Box Canyon: A Low-Yield Version of the W76 SLBM Warhead. Recognizing that new nuclear missions or weapons are not demanded by current circumstances ₋ a development path that yields future capabilities similar to those of today, which are adequate if not always ideal, and a broader national-security strategy that supports nonproliferation and arms control by reducing the role for, and numbers, of nuclear weapons ₋ we briefly consider alternate, less desirable futures, and their possible effect on the complex problem of regional deterrence. In this regard, we discuss the issues posed by, and possible responses to, three example regional deterrence challenges: in-country defensive use of nuclear weapons by an adversary; reassurance of U.S. allies with limited strategic depth threatened by an emergent nuclear power; and extraterritorial, non-strategic offensive use of nuclear weapons by an adversary in support of limited military objectives against a U.S. ally.« less

Essential Oils of Echinophora lamondiana (Apiales: Umbelliferae): A Relationship Between Chemical Profile and Biting Deterrence and Larvicidal Activity Against Mosquitoes (Diptera: Culicidae).

PubMed

Ali, Abbas; Tabanca, Nurhayat; Ozek, Gulmira; Ozek, Temel; Aytac, Zeki; Bernier, Ulrich R; Agramonte, Natasha M; Baser, K Husnu Can; Khan, Ikhlas A

2015-01-01

The essential oils from the flower, leaf, and stem of Echinophora lamondiana B.Yildiz et Z.Bahcecioglu were analyzed by gas chromatography-flame ionization detection and gas chromatography-mass spectrometry. In total, 41, 37, and 44 compounds were identified, which accounted for 98.0, 99.1, and 97.0% of flower, leaf, and stem essential oils, respectively. The monoterpenic hydrocarbons were found to be high in all samples of the essential oils. The major components of essential oils from flower, leaf, and stem of E. lamondiana were δ-3-carene (61.9, 75.0, and 65.9%, respectively), α-phellandrene (20.3, 14.1, and 12.8%, respectively), and terpinolene (2.7, 3.3, and 2.9%, respectively). Flower and leaf essential oils and terpinolene produced biting deterrence similar to 25 nmol/cm(2) N, N-diethyl-meta-toluamide (DEET; 97%) against Aedes aegypti (L.) and Anopheles quadrimaculatus Say. Compounds (+)-δ-3-carene, (R)-(-)-α-phellandrene, and water-distilled essential oils were significantly less repellent than DEET. Among essential oils, leaf oil was the least toxic of the oils, with an LC50 value of 138.3 ppm, whereas flower essential oil killed only 32% larvae, and no mortality of stem oil at highest tested dosages against Ae aegypti was observed. Terpinolene and α-phellandrene showed higher toxicity than δ-3-carene in both the species. In contrast to Ae. aegypti, all the essential oils showed toxicity in An. quadrimaculatus, and toxicity was higher in leaf oil than the other two oils. These results could be useful in finding new, safe, and more effective natural biopesticides and biting deterrent or repellents against Ae. aegypti. © The Author 2015. Published by Oxford University Press on behalf of the Entomological Society of America.For Permissions, please e-mail: journals.permissions@oup.com.

Variables Impacting an Academic Pharmacy Career Choice

PubMed Central

Brown, Bonnie K.; Byrd, Debbie C.; Gupchup, Gireesh V.; Mark, Scott M.; Mobley Smith, Miriam A.; Rospond, Raylene M.

2008-01-01

Objectives To identify the variables associated with an academic pharmacy career choice among the following groups: final professional-year doctor of pharmacy (PharmD) students, pharmacy residents, pharmacy faculty members within the first 5 years of academic employment, and clinical pharmacy practitioners. Methods A cross-sectional design Web-based survey instrument was developed using the online tool SurveyMonkey. The survey link was distributed via e-mail and postcards, and data were collected anonymously. Quantitative analyses were used to describe the 2,494 survey respondents and compare their responses to 25 variables associated with an academic pharmacy career choice. Logistic regression models were used to predict the motivators/deterrents associated with an academic pharmacy career choice for each participant group. Results Across all participant groups, the potential need to generate one's salary was the primary deterrent and autonomy, flexibility, and the ability to shape the future of the profession were the primary motivators. Final-year pharmacy students who considered a career in academic pharmacy were significantly deterred by grant writing. The overall sample of participants who considered an academic pharmacy career was more likely to be motivated by the academic environment and opportunities to teach, conduct professional writing and reviews, and participate in course design and/or assessment. Conclusions This study demonstrates specific areas to consider for improved recruitment and retention of pharmacy faculty. For example, providing experiences related to pharmacy academia, such as allowing student participation in teaching and research, may stimulate those individuals' interest in pursuing an academic pharmacy career. PMID:18698388

Waging modern war: An analysis of the moral literature on the nuclear arms debate

DOE Office of Scientific and Technical Information (OSTI.GOV)

Palmer-Fernandez, G.F.

1992-01-01

The primary aim was to examine the dominant views on the subject of deterrence and the use of nuclear weapons, to compare them with each other, and to consider objections that have or might be made against them. A second, more controversial and substantive, aim was to show that nuclear weapons and war-fighting plans engender some disturbing moral dilemmas that call into question fundamental ways of thinking about morality and some of the common intuitions on the relation of intentions and actions. The author examines the moral literature, both religious and secular, on nuclear arms policy written between the earlymore » 1960s and the late 1980s. Three different schools of thought, or parties,' are identified. To establish the differences among these parties, the author shows the various ways in which judgments on the use of nuclear weapons and on deterrence are linked either by a prohibitive moral principle which draws a moral equivalence going from action to intention or by a factual assumption about the nature of nuclear weapons. He concludes with the suggestion that the dilemmas that arise in the moral evaluation of nuclear deterrence represent a profound and much wider problem in moral theory between the ideals of character and the moral claims of politics.« less

Choosing Psychiatry as a Career: Motivators and Deterrents at a Critical Decision-Making Juncture

PubMed Central

Wiesenfeld, Lesley; Abbey, Susan; Takahashi, Sue Glover; Abrahams, Caroline

2014-01-01

Objective To examine factors influencing the choice of psychiatry as a career between residency program application and ranking decision making. Methods: Using an online questionnaire, applicants to the largest Canadian psychiatry residency program were surveyed about the impact of various factors on their ultimate decision to enter psychiatry residency training. Results: Applicants reported that patient-related stigma was a motivator in considering psychiatry as a career, but that negative comments from colleagues, friends, and family about choosing psychiatry was a deterrent. Training program length, limited treatments, and insufficient clerkship exposure were noted as deterrents to choosing psychiatry, though future job prospects, the growing role of neuroscience, and diagnostic complexity positively influenced choosing psychiatry as a specialty. Research and elective time away opportunities were deemed relatively unimportant to ranking decisions, compared with more highly weighted factors, such as program flexibility, emphasis on psychotherapy, service– training balance, and training program location. Most applicants also reported continuing to fine tune ranking decisions between the application and ranking submission deadline. Conclusions: Stigma, exposure to psychiatry, diagnostic complexity, and an encouraging job market were highlighted as positive influences on the choice to enter psychiatry residency. Interview and information days represent opportunities for continued targeted recruitment activity for psychiatry residency programs. PMID:25161070

Thermonuclear peace, the tightrope of deterrence

DOE Office of Scientific and Technical Information (OSTI.GOV)

Uscher, A.R.

This policy analysis focuses on the actions and approaches that will best reduce the chances of nuclear war in a MAD world, where mutual terror and mutual dependence will define our bipolar environment for the foreseeable future. The general approach to this broad and complex issue can be summarized as follows: since plans for conducting and preventing nuclear war are likely to be self-fulfilling prophecies, the US should strive for rational declaratory and deployment policies that reduce the chance of nuclear conflict while maintaining our national-security interests. Stability, probably the single most-important and unifying theme in nuclear deterrence, is visualizedmore » as a set of incentive structures that create no perceived advantages in escalating at any point along a hypothetical-force continuum. The key element in establishing and maintaining superpower stability is the inability to achieve adequate damage limitation through a preemptive first strike. The power and number of nuclear weapons compared to the fragility and limited number of priority targets seriously challenge the utility of most defensive measures. Successfully walking the tightrope of deterrence will require careful balancing of legitimate and competing values. This is a difficult task, but with a clear and realistic vision of the future, it is a feasible one.« less

Fluid Mechanics and Homeland Security

NASA Astrophysics Data System (ADS)

Settles, Gary S.

2006-01-01

Homeland security involves many applications of fluid mechanics and offers many opportunities for research and development. This review explores a wide selection of fluids topics in counterterrorism and suggests future directions. Broad topics range from preparedness and deterrence of impending terrorist attacks to detection, response, and recovery. Specific topics include aircraft hardening, blast mitigation, sensors and sampling, explosive detection, microfluidics and labs-on-a-chip, chemical plume dispersal in urban settings, and building ventilation. Also discussed are vapor plumes and standoff detection, nonlethal weapons, airborne disease spread, personal protective equipment, and decontamination. Involvement in these applications requires fluid dynamicists to think across the traditional boundaries of the field and to work with related disciplines, especially chemistry, biology, aerosol science, and atmospheric science.

Comprehensive Nuclear-Test-Ban Treaty: Background and Current Developments

DTIC Science & Technology

2009-01-28

safe. So he has not ruled out testing in the future, but there are no plans to do so.’”5 Critics expressed concern about the implications of these...nuclear weapons testing.”6 Another critic felt that increased funding for test readiness would in effect give prior approval for testing. In July 2002 a...moratorium. We may find at some future time that we cannot diagnose or remedy a problem in a warhead critical the U.S. nuclear deterrent without

Nuclear Deterrence 2035: Millennials Inheriting the Flight

DTIC Science & Technology

2017-06-01

SLBM 1992 W88 SLBM 1990 W80 ALCM/B-52 1961 B61 Bomb /B-2/B-52 1994 B83 Bomb /B-2/B-52 1994 35 must be savvy in how to leverage all aspects of...across the electromagnetic spectrum ( EMS ). However, each vector is currently only theoretical. There are treaty limitations that restrict war in space...February 2017). 41 cyberspace and hinder the development of a weapon in those domains. A weapon with effects in the EMS is most likely and its

A kinesthetic-tactual display for stall deterrence

NASA Technical Reports Server (NTRS)

Gilson, R. D.; Ventola, R. W.; Fenton, R. E.

1975-01-01

A kinesthetic tactual display may be effectively used as a control aid per previous flight tests. Angle of attack information would be continuously presented to a pilot, via this display, during critical operational phases where stalls are probable. A two phase plan for evaluating this concept is presented. A first development phase would encompass: (1) display fabrication for a conventional control yoke; (2) its installation, together with other necessary instrumentation, in an experimental aircraft; and (3) preliminary flight testing by experienced pilots.

Stockpile Stewardship: Los Alamos

ScienceCinema

McMillan, Charlie; Morgan, Nathanial; Goorley, Tom; Merrill, Frank; Funk, Dave; Korzekwa, Deniece; Laintz, Ken

2018-01-16

"Heritage of Science" is a short video that highlights the Stockpile Stewardship program at Los Alamos National Laboratory. Stockpile Stewardship was conceived in the early 1990s as a national science-based program that could assure the safety, security, and effectiveness of the U.S. nuclear deterrent without the need for full-scale underground nuclear testing. This video was produced by Los Alamos National Laboratory for screening at the Lab's Bradbury Science Museum in Los Alamos, NM and is narrated by science correspondent Miles O'Brien.

Predicting Alcohol Misuse Among College Students in the US and South Korea.

PubMed

Kim, Sang-Yeon; Ahn, Seokhoon; Lim, Tae-Seop

2015-01-01

This study examines contributing factors of alcohol misuse among college students in South Korea and the U.S. Exploratory factor analyses (EFA) on measurements of alcohol expectancy, alcohol efficacy, and accommodation resulted in social and personal causes for alcohol misuse. Social causes alone predicted alcohol misuse for both countries. Social factors constituted a much stronger predictor of alcohol misuse among South Korean students than among American students. Practical implications for effective deterrence of student binge drinking are discussed.

The arms race and nuclear war

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barash, D.P.

Addressing the history, physics, biology, economics, politics, psychology, and ethics of nuclear armaments, the author provides a survey of diverse facets of the nuclear controversy. The study encompasses such key areas as nuclear hardware and technology; the short- and long-term effects of nuclear weapons; strategic doctrine, deterrence and defense policy; the arms race, arms control, and nuclear proliferation; and the economic impact, psychology, and ethics of nuclear armaments. A ''Policy Issues'' section, presenting both the advocate and opponent sides of the debate, is included with each chapter.

Drug offence sentencing practices in the United States of America.

PubMed

Weissman, J C

1984-01-01

The United States criminal justice system, in response to a variety of risks, makes available a range of options to help control drug offenders. Pre-arrest diversion, pre-trial diversion, pre-trial release, probation, split sentencing, warn release, incarceration and parole release are alternative dispositions involving a graduated scale of punishment, incarceration, specific deterrence and rehabilitation. New drug offence sentencing policies are emerging within the criminal justice system. Traditional values of rehabilitation are currently less favoured and contemporary doctrines advocate sentencing based on principles of uniformity and retribution. Drug law sentencing practices are a principal concern of this article and the major policy themes are systematically reviewed. Diversion, criminal responsibility, selective incapacitation, trafficking, and cocaine abuse are examined. Guidelines for policy development are recommended and the analysis covers the related concepts of sentencing ideology, decriminalization, and determinate sentencing models. Specific recommendations are offered for revision of drug offence sentencing policies to incorporate the emerging penal values.

DTIC review. Volume 1, Number 1: Nuclear proliferation and deterrence in a changing political world

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cupp, C.M.; Lee, C.; Foster, H.

1995-08-01

This collection of selected documents from the Defense Technical Information Center (DTIC) addresses the formidable issue of protecting the United States and its people from potential nuclear destruction. With the dissolution of the former Soviet Union and, concomitantly, the end of the Cold War, new strategies for nonproliferation and deterrence must be devised and implemented. Potential threats from countries not previously seen as a danger, the escalation of regional conflicts and the proliferation of weapons of mass destruction are but a few of the considerations to be addressed. The authors of the following papers propose various plans and tactics tomore » ensure United States national security and maintain world peace.« less

The impact of no-fault compensation on health care expenditures: an empirical study of OECD countries.

PubMed

Vandersteegen, Tom; Marneffe, Wim; Cleemput, Irina; Vereeck, Lode

2015-03-01

Around the world, governments are faced with spiralling health care expenditures. This raises the need for further insight in the determinants of these expenditures. Existing literature focuses primarily on income, ageing, health care financing and supply variables. This paper includes medical malpractice system characteristics as determinants of health spending in OECD countries. Estimates from our regression models suggest that no-fault schemes for medical injuries with decoupling of deterrence and compensation reduce health expenditures per capita by 0.11%. Furthermore, countries that introduced a no-fault system without decoupling of deterrence and compensation are found to have higher (+0.06%) health care spending. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Stockpile Stewardship: How We Ensure the Nuclear Deterrent Without Testing

ScienceCinema

None

2018-01-16

In the 1990s, the U.S. nuclear weapons program shifted emphasis from developing new designs to dismantling thousands of existing weapons and maintaining a much smaller enduring stockpile. The United States ceased underground nuclear testing, and the Department of Energy created the Stockpile Stewardship Program to maintain the safety, security, and reliability of the U.S. nuclear deterrent without full-scale testing. This video gives a behind the scenes look at a set of unique capabilities at Lawrence Livermore that are indispensable to the Stockpile Stewardship Program: high performance computing, the Superblock category II nuclear facility, the JASPER a two stage gas gun, the High Explosive Applications Facility (HEAF), the National Ignition Facility (NIF), and the Site 300 contained firing facility.

Legislations combating counterfeit drugs in Hong Kong.

PubMed

Lai, C W; Chan, W K

2013-08-01

To understand legislation combating counterfeit drugs in Hong Kong. This study consisted of two parts. In part I, counterfeit drugs–related ordinances and court cases were reviewed. In part II, indepth interviews of the stakeholders were described. Hong Kong. All Hong Kong ordinances were screened manually to identify those combating counterfeit drugs. Court cases were searched for each of the identified cases. Then, the relevant judgement justifications were analysed to identify sentencing issues. Indepth interviews with the stakeholders were conducted to understand their perceptions about such legislation. Trade Marks Ordinance, Patents Ordinance, Trade Descriptions Ordinance, and Pharmacy and Poisons Ordinance were current legislative items combating counterfeit drugs. Sentencing criteria depended on: intention to deceive, quantity of seized drugs, presence of expected therapeutic effect or toxic ingredients, previous criminal records, cooperativeness with Customs officers, honest confessions, pleas of guilty, types of drugs, and precautionary measures to prevent sale of counterfeit drugs. Stakeholders’ perceptions were explored with respect to legislation regarding the scale and significance of the counterfeit drug problem, penalties and deterrents, drug-specific legislation and authority, and inspections and enforcement. To plug the loopholes, a specific law with heavy penalties should be adopted. This could be supplemented by non-legal measures like education of judges, lawyers, and the public; publishing the names of offending pharmacies; and emphasising the role of pharmacists to the public.

Transcriptome Analysis of Barbarea vulgaris Infested with Diamondback Moth (Plutella xylostella) Larvae

PubMed Central

Shen, Di; Wang, Haiping; Wu, Qingjun; Lu, Peng; Qiu, Yang; Song, Jiangping; Zhang, Youjun; Li, Xixiang

2013-01-01

Background The diamondback moth (DBM, Plutella xylostella) is a crucifer-specific pest that causes significant crop losses worldwide. Barbarea vulgaris (Brassicaceae) can resist DBM and other herbivorous insects by producing feeding-deterrent triterpenoid saponins. Plant breeders have long aimed to transfer this insect resistance to other crops. However, a lack of knowledge on the biosynthetic pathways and regulatory networks of these insecticidal saponins has hindered their practical application. A pyrosequencing-based transcriptome analysis of B. vulgaris during DBM larval feeding was performed to identify genes and gene networks responsible for saponin biosynthesis and its regulation at the genome level. Principal Findings Approximately 1.22, 1.19, 1.16, 1.23, 1.16, 1.20, and 2.39 giga base pairs of clean nucleotides were generated from B. vulgaris transcriptomes sampled 1, 4, 8, 12, 24, and 48 h after onset of P. xylostella feeding and from non-inoculated controls, respectively. De novo assembly using all data of the seven transcriptomes generated 39,531 unigenes. A total of 37,780 (95.57%) unigenes were annotated, 14,399 of which were assigned to one or more gene ontology terms and 19,620 of which were assigned to 126 known pathways. Expression profiles revealed 2,016–4,685 up-regulated and 557–5188 down-regulated transcripts. Secondary metabolic pathways, such as those of terpenoids, glucosinolates, and phenylpropanoids, and its related regulators were elevated. Candidate genes for the triterpene saponin pathway were found in the transcriptome. Orthological analysis of the transcriptome with four other crucifer transcriptomes identified 592 B. vulgaris-specific gene families with a P-value cutoff of 1e−5. Conclusion This study presents the first comprehensive transcriptome analysis of B. vulgaris subjected to a series of DBM feedings. The biosynthetic and regulatory pathways of triterpenoid saponins and other DBM deterrent metabolites in this plant were classified. The results of this study will provide useful data for future investigations on pest-resistance phytochemistry and plant breeding. PMID:23696897

NATO (North Atlantic Treaty Organization) deterrence and defense after the INF (Intermediate-Range Nuclear Forces) treaty. Final report, June 1988-June 1989

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garrett, S.A.

1989-06-21

The treaty between the Soviet Union and the United States eliminating a whole class of intermediate-range nuclear forces (INF) in Europe raises a number of questions about NATO's future ability to deter Warsaw Pact aggression. Future choices on Alliance strategy and doctrine will be influenced by a variety of factors, including the image of new thinking in Soviet security policy enunciated by General Secretary Gorbachev, changing West European opinion toward the use of nuclear weapons for NATO deterrence, the complications inherent in further nuclear and conventional arms-control negotiations, assessments of the current conventional arms balance in Europe, and ongoing questionsmore » about NATO cohesion as well as the continued coupling of American security with that of her European allies. In the post-INF environment it may well be that U.S. Navy nuclear assets will assume an increasingly important role, particularly the Tomahawk Land Attack Missile/Nuclear (TLAM/N). The TLAM/N has many attractive attributes that can be supportive of NATO deterrence of the WTO, but there are also a number of unresolved questions to be addressed concerning this particular weapons system. Modernization of NATO's land-based short-range nuclear forces (SNF), such as the Lance missile, is also seen by many as critical to the maintenance of Alliance security in the aftermath of INF.« less

Penny-Wise, Dollar-Foolish.

ERIC Educational Resources Information Center

Griffin, C. W.

1979-01-01

A veteran energy author discusses the economic deterrents to energy-conservation design measures inherent in the present tax laws, and proposes a standard energy tax reduction as a potential solution. (Author)

Assessment of extended-release opioid analgesics for the treatment of chronic pain.

PubMed

Gudin, Jeffrey A

2013-03-01

Approximately 3.8 million patients annually receive extended-release (ER) or long-acting opioid prescriptions in the outpatient setting, around half of which are written by primary care physicians. Compared with short-acting, immediate-release (IR) formulations, ER and oral long-acting opioid analgesics are associated with clinical advantages, such as extended periods of time during which drug plasma levels are within the therapeutic range, decreased peak-to-trough fluctuations, and prolonged analgesia over the dosing period. Additionally, ER opioids offer a more convenient, less frequent dosing regimen to chronic pain patients who are often taking several concomitant medications. The increased utilization of ER opioids has been accompanied by a rise in the misuse and abuse of these formulations. Certain pharmacokinetic parameters (e.g., longer time to maximum drug plasma concentration, lower maximum drug plasma concentration) may decrease the abuse potential of intact ER opioids by limiting the positive subjective and reinforcing effects relative to IR formulations. Putative abuse-deterrent formulations have also recently been introduced to impede physical manipulation of these formulations, or reduce the harm resulting from such behavior. Such formulations may represent an incremental advance to reduce non-oral forms of abuse. This article reviews the pharmacokinetic profiles and abuse-deterrent features of newer ER opioid analgesics for the treatment of moderate to severe chronic pain.

Ground squirrel tail-flag displays alter both predatory strike and ambush site selection behaviours of rattlesnakes

PubMed Central

Barbour, Matthew A.; Clark, Rulon W.

2012-01-01

Many species approach, inspect and signal towards their predators. These behaviours are often interpreted as predator-deterrent signals—honest signals that indicate to a predator that continued hunting is likely to be futile. However, many of these putative predator-deterrent signals are given when no predator is present, and it remains unclear if and why such signals deter predators. We examined the effects of one such signal, the tail-flag display of California ground squirrels, which is frequently given both during and outside direct encounters with northern Pacific rattlesnakes. We video-recorded and quantified the ambush foraging responses of rattlesnakes to tail-flagging displays from ground squirrels. We found that tail-flagging deterred snakes from striking squirrels, most likely by advertising squirrel vigilance (i.e. readiness to dodge a snake strike). We also found that tail-flagging by adult squirrels increased the likelihood that snakes would leave their ambush site, apparently by elevating the vigilance of nearby squirrels which reduces the profitability of the ambush site. Our results provide some of the first empirical evidence of the mechanisms by which a prey display, although frequently given in the absence of a predator, may still deter predators during encounters. PMID:22787023

Opioid Analgesics.

PubMed

Jamison, Robert N; Mao, Jianren

2015-07-01

Chronic pain is an international health issue of immense importance that is influenced by both physical and psychological factors. Opioids are useful in treating chronic pain but have accompanying complications. It is important for clinicians to understand the basics of opioid pharmacology, the benefits and adverse effects of opioids, and related problematic issues of tolerance, dependence, and opioid-induced hyperalgesia. In this article, the role of psychiatric comorbidity and the use of validated assessment tools to identify individuals who are at the greatest risk for opioid misuse are discussed. Additionally, interventional treatment strategies for patients with chronic pain who are at risk for opioid misuse are presented. Specific behavioral interventions designed to improve adherence with prescription opioids among persons treated for chronic pain, such as frequent monitoring, periodic urine screens, opioid therapy agreements, opioid checklists, and motivational counseling, are also reviewed. Use of state-sponsored prescription drug monitoring programs is also encouraged. Areas requiring additional investigation are identified, and the future role of abuse-deterrent opioids and innovative technology in addressing issues of opioid therapy and pain are presented. Copyright © 2015 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

Perceptions of family caring and its impact on peer associations and drug involvement among rural dwelling African American and White adolescents.

PubMed

Taylor, Matthew J; Merritt, Stephanie M; Brown, Carrie M

2012-01-01

The purpose of this study was to investigate the premise that adolescent perceptions of family caring are a precipitating source of substance use deterrence. More specifically, this study examined the role of family caring on communication of substance use harm and sanctions of use and the effect of these on peer substance involvement and individual use outcomes. A sample of rural dwelling African American and White 7th and 8th grade students (N = 1780) was assessed through self-report. It was anticipated that family caring would be positively related to harm communication and sanctions of use, and that these would be negatively related to peer substance involvement and individual use. Results suggest that family caring was positively linked to harm communication and sanctions of use, and that these were both negatively related to peer substance involvement and individual use. Several significant race differences were noted, which suggest differential associations between some variables. Results are discussed in terms of these race differences, as well as in terms of rural residency.

Fluorescent blue lights, injecting drug use and related health risk in public conveniences: findings from a qualitative study of micro-injecting environments.

PubMed

Parkin, Stephen; Coomber, Ross

2010-07-01

This paper presents findings relating to injecting drug users' experiences and opinions of public toilets illuminated with fluorescent blue lights and presents an empirical assessment of the intended deterrent effect of such installations. Data analysis identified that blue lights deterred less than half the sample interviewed. Furthermore over half (18/31) of the sample were prepared to inject in conditions specifically designed to deter injecting practice. Of these, 11 respondents were completely undeterred and 7 individuals were only partially deterred by blue light environments. These findings are discussed within the interpretative frameworks of Pierre Bourdieu's theory of habitus and symbolic violence. The authors conclude that fluorescent blue lights contribute towards the development of situated resistance by injecting drug users within a public injecting habitus; a resistance that produces and reproduces drug-related harm and is a behaviour that opposes the symbolic violence of harm reduction intervention. The paper concludes with suggestions for theory-driven practical intervention that may seek to disrupt the harmful elements of the public injecting habitus. 2010 Elsevier Ltd. All rights reserved.

Assurance Penalty Level Analysis Final Rule TSD

EPA Pesticide Factsheets

This Technical Support Document (TSD) supports EPA’s determination that the final Transport Rule’s assurance provision penalty requirement provides sufficient deterrence against a state exceeding its assurance level.

Stockpile Stewardship: How We Ensure the Nuclear Deterrent Without Testing

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2014-09-04

In the 1990s, the U.S. nuclear weapons program shifted emphasis from developing new designs to dismantling thousands of existing weapons and maintaining a much smaller enduring stockpile. The United States ceased underground nuclear testing, and the Department of Energy created the Stockpile Stewardship Program to maintain the safety, security, and reliability of the U.S. nuclear deterrent without full-scale testing. This video gives a behind the scenes look at a set of unique capabilities at Lawrence Livermore that are indispensable to the Stockpile Stewardship Program: high performance computing, the Superblock category II nuclear facility, the JASPER a two stage gas gun,more » the High Explosive Applications Facility (HEAF), the National Ignition Facility (NIF), and the Site 300 contained firing facility.« less

Chrysolina herbacea Modulates Terpenoid Biosynthesis of Mentha aquatica L.

PubMed Central

Atsbaha Zebelo, Simon; Bertea, Cinzia M.; Bossi, Simone; Occhipinti, Andrea; Gnavi, Giorgio; Maffei, Massimo E.

2011-01-01

Interactions between herbivorous insects and plants storing terpenoids are poorly understood. This study describes the ability of Chrysolina herbacea to use volatiles emitted by undamaged Mentha aquatica plants as attractants and the plant's response to herbivory, which involves the production of deterrent molecules. Emitted plant volatiles were analyzed by GC-MS. The insect's response to plant volatiles was tested by Y-tube olfactometer bioassays. Total RNA was extracted from control plants, mechanically damaged leaves, and leaves damaged by herbivores. The terpenoid quantitative gene expressions (qPCR) were then assayed. Upon herbivory, M. aquatica synthesizes and emits (+)-menthofuran, which acts as a deterrent to C. herbacea. Herbivory was found to up-regulate the expression of genes involved in terpenoid biosynthesis. The increased emission of (+)-menthofuran was correlated with the upregulation of (+)-menthofuran synthase. PMID:21408066

Peace and war: a study of morality and US strategic nuclear policies. Study project report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ginder, D.B.; Hicks, I.

1983-05-01

The paper examines the quesitons of peace and war and the morality of nuclear deterrence. These vital and enduring questions have been again become a focus of societal debate, especially in the light of the Catholic Bishop's pastoral letter. The nuclear debate is all encompassing, raising philosophical, political, social, strategic an religious questions. These issues present problems that each informed citizen will have to discern both morally and politically. The purpose of the paper is not to evaluate the morality of the defense and deterrent policies/strategies of the United States, but to provide the reader with the information to allowmore » him to formulate judgment on this important question and be able to reconcile personal moral values with national policy and strategy.« less

Complementary and Alternative Medicine Use in Minority and Medically Underserved Oncology Patients: Assessment and Implications.

PubMed

Jones, Desiree; Cohen, Lorenzo; Rieber, Alyssa G; Urbauer, Diana; Fellman, Bryan; Fisch, Michael J; Nazario, Arlene

2018-06-01

Complementary and alternative medicine (CAM) use in minority and medically underserved oncology patients is not well documented. We assessed knowledge and utilization of CAM in a sample of these patients receiving treatment at an urban community hospital. Patients with cancer were interviewed using an electronic application that depicted specific CAM therapies. Patients were questioned on their knowledge and utilization of therapies, deterrents to use, and interest in using these therapies if they were made available. Patients (n = 165) reported a high awareness and use of CAM therapies. CAM use was highest for prayer (85%), relaxation (54%), special diet (29%), meditation (19%), and massage (18%). Patients' interest in using CAM was high for nearly all therapies. Lack of adequate knowledge and cost of use were reported as deterrents to use. Female patients reported higher use of aromatherapy relative to males (37.1% vs 19.4%, P = .02); those with higher education reported greater use of relaxation (60.8% vs 28.6%, P = .02); non-Hispanics reported higher use of relaxation relative to Hispanics (63.5% vs 44.2%, P = .03), and African American patients reported higher use of relaxation relative to White patients (69.2% vs 50%, P = .03). CAM use in minority and medically underserved cancer patients is common, but not professionally guided; thus, concerns remain regarding its safe use. Our data underscore the importance of patient-physician dialogue regarding CAM use in this patient population, and interest in access to the medically guided integration of evidence-based CAM therapies.

Surgical and radiological effects upon the development of speech after total laryngectomy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Richardson, J.L.

1981-01-01

The data presented examine the relationship between postlaryngectomy communication method, and the extent of total laryngectomy and the use of radiation therapy. The expectations of speech therapy providers were also examined. The author interviewed 60 laryngectomy patients who were six months to 3 1/2 years postsurgery. Surgeries were grouped into four categories and correlated with communication method. The relationship was statistically significant with the most apparent deterrent effect exhibited only for the most extreme surgical excisions. There was no relationship with the use of radiation therapy. In many cases speech therapy providers' expectations were not supported by the data.

Nuclear Weapons and Science Education.

ERIC Educational Resources Information Center

Wellington, J. J.

1984-01-01

Provides suggestions on how science teachers can, and should, deal with the nuclear weapons debate in a balanced and critical way. Includes a table outlining points for and against deterrence and disarmament. (JN)

Chemical and biological warfare. Should defenses be researched and deployed?

PubMed

Orient, J M

1989-08-04

The threat of chemical and biological weapons of mass destruction has intensified because of improved delivery systems and advances in chemistry, genetics, and other sciences. Possible US responses to this threat include deterrence, defenses, and/or disarmament, including a reaffirmation of the Biological and Toxin Weapons Convention of 1972, which is now in jeopardy. This article discusses the history of chemical and biological warfare, existing and potential weapons, the proliferation of weapons and delivery systems, ways to prevent the use of these weapons, and ways to protect populations from their effects.

Science, Technology and the Nuclear Arms Race

NASA Astrophysics Data System (ADS)

Schroeer, Dietrich

1984-09-01

A comprehensive survey of the nuclear arms race from a technological point of view, which will appeal to the scientist and non-scientist alike. Provides information for the layman on this current topic and is designed for undergraduate courses in political science, history, international studies, as well as physics courses on the subject. Explores the motivation behind the development of various nuclear arms technologies and their deployment and examines the effects these technologies have on military, political and social strategies. Discusses the nature of deterrence and alternatives to it, arms control, and disarmament.

Volcanism and soil mercury on Mars - Consequences for terrestrial microorganisms

NASA Technical Reports Server (NTRS)

Siegel, B. Z.; Siegel, S. M.

1978-01-01

An earth-Mars depletion formula proposed by Anders and Owen for volatiles is used to calculate a range of putative Hg levels for Martian volcanic soils based upon analyzed samples from Hawaii. The range is about 50-150 microgram per kg. When applied either in conventional or special media (e.g., basalt powder), these levels of Hg are effective inhibitors of the growth of earth microorganisms. Taken together with other hostile chemical and physical factors, volcanic toxicants would appear to provide a further deterrent to the accidental establishment of terrestrial microbiota on Mars.

Targets of opportunity : community based alcohol programs

DOT National Transportation Integrated Search

1988-04-01

Targets of Opportunity (TOP), were comprehensive community based programs addressing the drinking and driving concerns within a particular community. The program incorporated six elements: 1) General deterrence - public information,leducation and enf...

Extended Deterrence, Nuclear Proliferation, and START III

DOE Office of Scientific and Technical Information (OSTI.GOV)

Speed, R.D.

2000-06-20

Early in the Cold War, the United States adopted a policy of ''extended nuclear deterrence'' to protect its allies by threatening a nuclear strike against any state that attacks these allies. This threat can (in principle) be used to try to deter an enemy attack using conventional weapons or one using nuclear, chemical, or biological weapons. The credibility of a nuclear threat has long been subject to debate and is dependent on many complex geopolitical factors, not the least of which is the military capabilities of the opposing sides. The ending of the Cold War has led to a significantmore » decrease in the number of strategic nuclear weapons deployed by the United States and Russia. START II, which was recently ratified by the Russian Duma, will (if implemented) reduce the number deployed strategic nuclear weapons on each side to 3500, compared to a level of over 11,000 at the end of the Cold War in 1991. The tentative limit established by Presidents Clinton and Yeltsin for START III would reduce the strategic force level to 2000-2500. However, the Russians (along with a number of arms control advocates) now argue that the level should be reduced even further--to 1500 warheads or less. The conventional view is that ''deep cuts'' in nuclear weapons are necessary to discourage nuclear proliferation. Thus, as part of the bargain to get the non-nuclear states to agree to the renewal of the Nuclear Non-Proliferation Treaty, the United States pledged to work towards greater reductions in strategic forces. Without movement in the direction of deep cuts, it is thought by many analysts that some countries may decide to build their own nuclear weapons. Indeed, this was part of the rationale India used to justify its own nuclear weapons program. However, there is also some concern that deep cuts (to 1500 or lower) in the U.S. strategic nuclear arsenal could have the opposite effect. The fear is that such cuts might undermine extended deterrence and cause a crisis in confidence among U.S. allies to such an extent that they could seek nuclear weapons of their own to protect themselves.« less

Is harm reduction profitable? An analytical framework for corporate social responsibility based on an epidemic model of addictive consumption.

PubMed

Massin, Sophie

2012-06-01

This article aims to help resolve the apparent paradox of producers of addictive goods who claim to be socially responsible while marketing a product clearly identified as harmful. It advances that reputation effects are crucial in this issue and that determining whether harm reduction practices are costly or profitable for the producers can help to assess the sincerity of their discourse. An analytical framework based on an epidemic model of addictive consumption that includes a deterrent effect of heavy use on initiation is developed. This framework enables us to establish a clear distinction between a simple responsible discourse and genuine harm reduction practices and, among harm reduction practices, between use reduction practices and micro harm reduction practices. Using simulations based on tobacco sales in France from 1950 to 2008, we explore the impact of three corresponding types of actions: communication on damage, restraining selling practices and development of safer products on total sales and on the social cost. We notably find that restraining selling practices toward light users, that is, preventing light users from escalating to heavy use, can be profitable for the producer, especially at early stages of the epidemic, but that such practices also contribute to increase the social cost. These results suggest that the existence of a deterrent effect of heavy use on the initiation of the consumption of an addictive good can shed new light on important issues, such as the motivations for corporate social responsibility and the definition of responsible actions in the particular case of harm reduction. Copyright © 2012 Elsevier Ltd. All rights reserved.

Effects of dietary esfenvalerate exposures on three aquatic insect species representing different functional feeding groups.

PubMed

Palmquist, Katherine R; Jenkins, Jeffrey J; Jepson, Paul C

2008-08-01

Given the chemical properties of synthetic pyrethroids, it is probable that compounds, including esfenvalerate, that enter surface waters may become incorporated into aquatic insect food sources. We examined the effect of dietary esfenvalerate uptake in aquatic insects representing different functional feeding groups. We used three field-collected aquatic insect species: A grazing scraper, Cinygmula reticulata McDunnough (Ephemeroptera: Heptageniidae); an omnivorous filter feeder, Brachycentrus americanus Banks (Trichoptera: Brachycentridae); and a predator, Hesperoperla pacifica Banks (Plecoptera: Perlidae). Laboratory-cultured algae were preexposed for 24 h to esfenvalerate concentrations of 0, 0.025, 0.05, and 0.1 microg/L and provided to two C. reticulata age classes (small and final-instar nymphs). Reduction in small nymph growth was observed following three weeks of feeding on algae exposed to 0.05 and 0.1 microg/L of esfenvalerate, and the highest dietary exposure reduced egg production in final-instar nymphs. The diet for B. americanus and H. pacifica consisted of dead third-instar Chironomus tentans larvae preexposed for 24 h to esfenvalerate concentrations ranging between 0.1 and 1.0 microg/L. Consumption of larvae exposed to 0.5 to 1.0 microg/L of esfenvalerate caused case abandonment and mortality in B. americanus caddisfly larvae. Although H. pacifica nymphs readily consumed esfenvalerate-exposed larvae, no adverse effects were observed during the present study. Furthermore, no evidence of esfenvalerate-induced feeding deterrence was found in any of the species tested, suggesting that aquatic insects may not be able to distinguish between pyrethroid-contaminated and uncontaminated food sources. These findings indicate that feeding deterrence is not a factor in regulating aquatic insect dietary exposures to synthetic pyrethroids.

Insect deterrent and nematicidal screening of microfungi from Mexico and anti-aphid compounds from Gliomastix masseei.

PubMed

Ruiz-Jiménez, Ana L; González-Coloma, Azucena; Andrés-Yeves, Mari Fe; Ruiz-Sánchez, Esaú; Heredia, Gabriela; Peraza-Sánchez, Sergio R; Medina-Baizabal, Irma L; Reyes-Estebanez, Manuela; Canto-Canché, Blondy; Gamboa-Angulo, Marcela

Fungal metabolites are promising alternatives for the development of biorational pesticides. In this sense, microfungi from tropical regions are valuable sources of natural compounds for pest management. With the aim of broadening the search for new eco-friendly products to manage plant pests, this study was carried out to evaluate the biological activity of 23 tropical fungal extracts on three species of phytophagous insects and a plant parasitic nematode. In addition, the active principles of the most effective extract were identified. The insect deterrent activity of fungal extracts was evaluated on the settling of aphids Myzus persicae and Rhopalosiphum padi, and on the feeding of lepidoptera larva Spodoptera littoralis; the nematostatic activity was evaluated on the mobility of Meloidogyne javanica. Active metabolites from Gliomastix masseei were identified by GC-MS techniques and by comparison with commercial standards. Results showed seven extracts with strong effect on the settling of M. persicae and R. padi (settling inhibition >80%). The calculated median of effective concentration (EC 50 ) values ranged from 8 to 38μg/cm 2 for the extracts of Clonostachys rosea and G. masseei, respectively. Bioassay-guided separation of the ethyl acetate extract of G. masseei revealed the presence of fatty acids and their derivatives, where methyl 9-octadecenoate was the most active compound with EC 50 values of 16μg and 35μg/cm 2 for M. persicae and R. padi, respectively. Extracts of C. rosea and G. masseei could be a promising option in the control of pest aphids in agriculture. Copyright © 2016 Asociación Argentina de Microbiología. Publicado por Elsevier España, S.L.U. All rights reserved.

Intranasal abuse potential of an abuse-deterrent oxycodone formulation compared to oxycodone immediate release and placebo in nondependent, recreational opioid users.

PubMed

Setnik, Beatrice; Schoedel, Kerri; Bartlett, Cindy; Dick, Chris; Hakim, Nasrat; Geoffroy, Pierre

To assess the intranasal (IN) human abuse potential of ELI-200, a novel immediate-release (IR) oxycodone formulation containing sequestered naltrexone. Randomized, double-blind, double-dummy, active and placebo-controlled, five-way crossover study. Pharmacodynamics, safety, and pharmacokinetics (PKs) were evaluated for up to 36 hours postdose. Single site in Canada (INC Research Toronto). Healthy male and female nondependent recreational opioid users underwent a naloxone challenge and drug discrimination qualification test. Single IN dose of ground ELI-200 (30-mg oxycodone hydrochloride [HCl]/3-mg naltrexone HCl), crushed 30-mg oxycodone HCl IR (Roxicodone®), placebo, fixed placebo, and single oral dose of intact ELI-200 (30mg/3mg). Peak effect (E max ) for bipolar Drug Liking (0-100 point visual analog scale). Of the 44 randomized subjects, 37 completed all five treatment periods. All active treatments showed significantly higher (p<0.001) median Drug Liking E max relative to placebo. Significant reductions (p<0.001) in median Drug Liking [E max ] were observed for IN ELI-200 [56.0] compared to IN oxycodone IR [100.0]. Secondary positive or objective measures (High, Good Drug Effects, Overall Drug Liking, Take Drug Again, and maximum pupil constriction) showed significantly lower E max for IN ELI-200 (p<0.001) compared to IN oxycodone IR. IN administration of ELI-200 demonstrated significantly decreased effects on subjective and physiologic measures, and greater nasal irritation, compared to IN oxycodone IR. These findings, along with the PK profile of naltrexone, demonstrated that when ELI-200 capsules were ground and administered intranasally, the naltrexone component was rapidly released and conferred meaningful abuse-deterrent properties.

The specific deterrence of administrative per se laws in reducing drunk driving recidivism.

PubMed

McArthur, D L; Kraus, J F

1999-01-01

To determine if administrative per se laws are more effective than other forms of sanction against drunk drivers. The overall goal of the search strategy was to identify all relevant research concerning the specific effects of administrative per se laws in reducing drunk driving recidivism, traffic crashes, and other alcohol-related driving offenses by those drivers with suspended licenses. Known review articles and MEDLINE reviews formed the reference bibliography; numerous databases were searched from 1966 to the present, using such terms as alcohol, driver's license, recidivism, deterrence, and legislation. To be selected the study had to be designed to test the presence of an administrative per se license revocation or restriction in a defined cohort, have a suitable comparison cohort whose sanctions for drunk driving were not administrative per se, and provide relevant data that lead to an objective assessment of recidivism. Types of studies included were randomized controlled trials, nonrandomized controlled trials, other specialized cohort studies, and case-control studies. Three studies were identified; all met inclusion criteria. One of the studies provided Kaplan-Meier survival curves for failure times defined as days to new conviction following the initial arrest. Odds ratios and 99% confidence intervals were extracted from two of the studies and additional information was supplied by the author of one of the studies. One study found that one state in the United States experienced a reduction of about one third in repeat arrests for drunk driving over a 3-year period among those who were arrested under administrative per se, relative to recidivism seen in a comparison cohort of drivers prior to administrative per se. Two other states did not experience any change in recidivism. The second study found that drivers whose licenses were suspended under administrative per se were 39% less likely during the first year following suspension to be rearrested on the charge of driving while intoxicated compared with a comparison cohort. This differential persisted into the second year of follow-up, but disappeared by the third year. The third study found both first offenders and repeat offenders arrested under administrative per se were 34% less likely to be involved during the year following their arrest in a subsequent motor vehicle crash compared with those in the comparison cohort. Drivers with administrative per se suspensions were 21% less likely to be involved in additional drunk driving offenses, and 27% less likely to be involved in reckless driving offenses related to alcohol. Administrative per se laws governing license restriction for drivers have been shown to be effective in some states but not others in decreasing the rates at which these same drivers are subsequently involved in a motor vehicle crash or in another alcohol-related offense, compared with drivers who were sanctioned through other conventional judicial processes. Replications are needed in other states or large driver populations using improved methodology.

International Parental Child Abduction Deterrence Act

THOMAS, 111th Congress

Rep. Holt, Rush [D-NJ-12

2009-07-31

House - 09/14/2009 Referred to the Subcommittee on Immigration, Citizenship, Refugees, Border Security, and International Law. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Determinants of plasma donation: A review of the literature.

PubMed

Beurel, A; Terrade, F; Lebaudy, J-P; Danic, B

2017-09-01

The major contribution of Human Sciences in the understanding of the whole blood donation behavior has been through the study of individuals' motivations and deterrents to donate. However, if whole blood donation has been very widely studied in the last sixty years, we still know very little about plasma donation in voluntary non-remunerated environments. Yet, the need for plasma-derived products has been strongly increasing for some years, and blood collection agencies have to adapt if they want to meet this demand. This article aims to review the main motivations and deterrents to whole blood donation, and to compare them with those that we already know concerning plasma donation. Current evidence shows similarities between both behaviors, but also differences that indicate a need for further research regarding plasma donation. Copyright © 2017. Published by Elsevier SAS.

Using Caffeine Pills for Performance Enhancement. An Experimental Study on University Students' Willingness and Their Intention to Try Neuroenhancements.

PubMed

Brand, Ralf; Koch, Helen

2016-01-01

Recent research has indicated that university students sometimes use caffeine pills for neuroenhancement (NE; non-medical use of psychoactive substances or technology to produce a subjective enhancement in psychological functioning and experience), especially during exam preparation. In our factorial survey experiment, we manipulated the evidence participants were given about the prevalence of NE amongst peers and measured the resulting effects on the psychological predictors included in the Prototype-Willingness Model of risk behavior. Two hundred and thirty-one university students were randomized to a high prevalence condition (read faked research results overstating usage of caffeine pills amongst peers by a factor of 5; 50%), low prevalence condition (half the estimated prevalence; 5%) or control condition (no information about peer prevalence). Structural equation modeling confirmed that our participants' willingness and intention to use caffeine pills in the next exam period could be explained by their past use of neuroenhancers, attitude to NE and subjective norm about use of caffeine pills whilst image of the typical user was a much less important factor. Provision of inaccurate information about prevalence reduced the predictive power of attitude with respect to willingness by 40-45%. This may be because receiving information about peer prevalence which does not fit with their perception of the social norm causes people to question their attitude. Prevalence information might exert a deterrent effect on NE via the attitude-willingness association. We argue that research into NE and deterrence of associated risk behaviors should be informed by psychological theory.

Using Caffeine Pills for Performance Enhancement. An Experimental Study on University Students’ Willingness and Their Intention to Try Neuroenhancements

PubMed Central

Brand, Ralf; Koch, Helen

2016-01-01

Recent research has indicated that university students sometimes use caffeine pills for neuroenhancement (NE; non-medical use of psychoactive substances or technology to produce a subjective enhancement in psychological functioning and experience), especially during exam preparation. In our factorial survey experiment, we manipulated the evidence participants were given about the prevalence of NE amongst peers and measured the resulting effects on the psychological predictors included in the Prototype-Willingness Model of risk behavior. Two hundred and thirty-one university students were randomized to a high prevalence condition (read faked research results overstating usage of caffeine pills amongst peers by a factor of 5; 50%), low prevalence condition (half the estimated prevalence; 5%) or control condition (no information about peer prevalence). Structural equation modeling confirmed that our participants’ willingness and intention to use caffeine pills in the next exam period could be explained by their past use of neuroenhancers, attitude to NE and subjective norm about use of caffeine pills whilst image of the typical user was a much less important factor. Provision of inaccurate information about prevalence reduced the predictive power of attitude with respect to willingness by 40-45%. This may be because receiving information about peer prevalence which does not fit with their perception of the social norm causes people to question their attitude. Prevalence information might exert a deterrent effect on NE via the attitude-willingness association. We argue that research into NE and deterrence of associated risk behaviors should be informed by psychological theory. PMID:26903909

21 CFR 14.100 - List of standing advisory committees.

Code of Federal Regulations, 2012 CFR

2012-04-01

... research relevant to such communication to the public by both FDA and other entities. It also facilitates... analgesics, e.g., abuse-deterrent opioids, novel analgesics, and issues related to opioid abuse, and those...

21 CFR 14.100 - List of standing advisory committees.

Code of Federal Regulations, 2013 CFR

2013-04-01

... research relevant to such communication to the public by both FDA and other entities. It also facilitates... analgesics, e.g., abuse-deterrent opioids, novel analgesics, and issues related to opioid abuse, and those...

21 CFR 14.100 - List of standing advisory committees.

Code of Federal Regulations, 2014 CFR

2014-04-01

... research relevant to such communication to the public by both FDA and other entities. It also facilitates... analgesics, e.g., abuse-deterrent opioids, novel analgesics, and issues related to opioid abuse, and those...

45 CFR 30.23 - Enforcement policy.

Code of Federal Regulations, 2012 CFR

2012-10-01

... of deterrence and securing compliance, present and future, will be adequately served by the Secretary's acceptance of the sum to be agreed upon. ... § 30.23 Enforcement policy. The Secretary may compromise statutory penalties, forfeitures, or claims...

45 CFR 30.23 - Enforcement policy.

Code of Federal Regulations, 2011 CFR

2011-10-01

... of deterrence and securing compliance, present and future, will be adequately served by the Secretary's acceptance of the sum to be agreed upon. ... § 30.23 Enforcement policy. The Secretary may compromise statutory penalties, forfeitures, or claims...

45 CFR 30.23 - Enforcement policy.

Code of Federal Regulations, 2013 CFR

2013-10-01

... of deterrence and securing compliance, present and future, will be adequately served by the Secretary's acceptance of the sum to be agreed upon. ... § 30.23 Enforcement policy. The Secretary may compromise statutory penalties, forfeitures, or claims...

45 CFR 30.23 - Enforcement policy.

Code of Federal Regulations, 2014 CFR

2014-10-01

... of deterrence and securing compliance, present and future, will be adequately served by the Secretary's acceptance of the sum to be agreed upon. ... § 30.23 Enforcement policy. The Secretary may compromise statutory penalties, forfeitures, or claims...

45 CFR 30.23 - Enforcement policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... of deterrence and securing compliance, present and future, will be adequately served by the Secretary's acceptance of the sum to be agreed upon. ... § 30.23 Enforcement policy. The Secretary may compromise statutory penalties, forfeitures, or claims...

Radioactive Import Deterrence Act

THOMAS, 111th Congress

Rep. Gordon, Bart [D-TN-6

2009-01-14

Senate - 12/03/2009 Received in the Senate and Read twice and referred to the Committee on Environment and Public Works. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

Saving Human Lives: What Complexity Science and Information Systems can Contribute

NASA Astrophysics Data System (ADS)

Helbing, Dirk; Brockmann, Dirk; Chadefaux, Thomas; Donnay, Karsten; Blanke, Ulf; Woolley-Meza, Olivia; Moussaid, Mehdi; Johansson, Anders; Krause, Jens; Schutte, Sebastian; Perc, Matjaž

2015-02-01

We discuss models and data of crowd disasters, crime, terrorism, war and disease spreading to show that conventional recipes, such as deterrence strategies, are often not effective and sufficient to contain them. Many common approaches do not provide a good picture of the actual system behavior, because they neglect feedback loops, instabilities and cascade effects. The complex and often counter-intuitive behavior of social systems and their macro-level collective dynamics can be better understood by means of complexity science. We highlight that a suitable system design and management can help to stop undesirable cascade effects and to enable favorable kinds of self-organization in the system. In such a way, complexity science can help to save human lives.

Saving Human Lives: What Complexity Science and Information Systems can Contribute.

PubMed

Helbing, Dirk; Brockmann, Dirk; Chadefaux, Thomas; Donnay, Karsten; Blanke, Ulf; Woolley-Meza, Olivia; Moussaid, Mehdi; Johansson, Anders; Krause, Jens; Schutte, Sebastian; Perc, Matjaž

We discuss models and data of crowd disasters, crime, terrorism, war and disease spreading to show that conventional recipes, such as deterrence strategies, are often not effective and sufficient to contain them. Many common approaches do not provide a good picture of the actual system behavior, because they neglect feedback loops, instabilities and cascade effects. The complex and often counter-intuitive behavior of social systems and their macro-level collective dynamics can be better understood by means of complexity science. We highlight that a suitable system design and management can help to stop undesirable cascade effects and to enable favorable kinds of self-organization in the system. In such a way, complexity science can help to save human lives.

Canada's new drug-impaired driving law: the need to consider other approaches.

PubMed

Solomon, Robert; Chamberlain, Erika

2014-01-01

The objects of this study were: To review the state of drug-impaired driving in Canada, particularly in light of the 2008 amendments to the Criminal Code, which authorized police to demand standardized field sobriety testing and drug recognition evaluations, and to consider whether alternative enforcement models would be more effective in terms of detecting and prosecuting drug-impaired drivers and thereby achieve greater deterrence. This article provides a review of survey data, roadside screening studies, and postmortem reports that indicate the prevalence of driving after drug use in Canada. It evaluates the Criminal Code's 2008 amendments and their impact on charges and convictions for drug-impaired driving. It then reviews some alternative enforcement models for drug-impaired driving that have been adopted in other jurisdictions, particularly toxicological testing, and evaluates them against Canada's social, political, and constitutional framework. Survey data, roadside screening studies, and postmortem reports indicate that driving after drug use is commonplace and is now more prevalent among young people than driving after drinking. Unfortunately, the 2008 Criminal Code amendments have not had their desired effects. The measures have proven to be costly, time-consuming, and cumbersome, and are readily susceptible to challenge in the courts. Accordingly, the charge rates for drug-impaired driving remain extremely low, and the law has had minimal deterrent effects. The review of alternative enforcement models suggests that a system of random roadside saliva screening, somewhat similar to the model used in Victoria, Australia, will be the most effective in terms of detecting and prosecuting drug-impaired drivers and most consistent with Canada's legal and constitutional system. Canada should establish per se limits for the most commonly used drugs, enforceable through a system of screening and evidentiary tests. This will be more efficient and cost-effective and will result in more reliable evidence for criminal trials. Although this system will inevitably be subject to constitutional challenge, existing case law suggests that it should be upheld as a reasonable limit on constitutional rights.

Influence ofAmaranthus hybridus L. allelochemics on oviposition behavior ofSpodoptera exigua andS. eridania (Lepidoptera: Noctuidae).

PubMed

Mitchell, E R; Heath, R R

1985-05-01

Common pigweed,Amaranthus hybridus L., is a favorite host of the beet army worm (BAW),Spodoptera exigua L. Chemicals extracted from homogenized pigweed with distilled water, ethanol, or dichloromethane and sprayed back on pigweed deterred oviposition by the BAW. Similarly, water extracts of frass from conspecific larvae or southern armyworm (SAW) larvae,S. eridania (Cramer), fed pigweed leaves and sprayed back on pigweed plants also deterred BAW oviposition, thus confirming that deterrence was due to plant allelochemics rather than specific compounds associated with the metabolic or excretory products of the larvae. Confirmation of the presence of oviposition-deterring chemicals in pigweed was used to explain a previously observed seasonal displacement of BAW by SAW on pigweed in the field.

Expression of Resistance in Amaranthus spp. (Caryophyllales: Amaranthaceae): Effects of Selected Accessions on the Behaviour and Biology of the Amaranth Leaf-Webber, Spoladea recurvalis (Lepidoptera: Crambidae).

PubMed

Othim, Stephen T O; Ramasamy, Srinivasan; Kahuthia-Gathu, Ruth; Dubois, Thomas; Ekesi, Sunday; Fiaboe, Komi K M

2018-06-08

Spoladea recurvalis F. is a major pest moth of amaranth ( Amaranthus spp.) flowers worldwide, with a potential of causing complete foliage loss under severe outbreaks. Chemical insecticides are uneconomical for resource-poor farmers and pose health and environmental risks. Host plant resistance (HPR) to insects is an effective, economical and environmentally friendly alternative that is poorly understood and largely unexploited among traditional leafy vegetables. A total of 35 amaranth accessions were evaluated for the expression of their antixenotic and antibiotic traits against S. recurvalis , focusing on their effects on the biology of the pest in comparison with a susceptible accession. The accession VI036227 was found to be highly resistant against the pest, exhibiting exemplary antibiosis by causing 100% larval mortality within the first 36 h, despite not being deterrent for oviposition. The accessions VI048076, VI056563 and VI047555-B demonstrated moderate resistance against the pest for specific parameters including low oviposition, moderate early stage larval mortality and reduced adult longevity. Total mortality and weight gain in these three accessions were, however, not significantly different from the susceptible control. Higher numbers of eggs were laid in no-choice compared to choice situations. The implications of these findings in the management of S. recurvalis on amaranths are discussed.

Litigation and complaints procedures: objectives, effectiveness and alternatives.

PubMed Central

Whelan, C J

1988-01-01

Recent debates about redress mechanisms for medical accident victims have been sidetracked by fears of an American-style medical malpractice crisis. What is required is a framework within which the debate can resume. This paper proposes such a framework by focusing on the compensation and deterrence objectives and placing them in the wider context of the social costs of providing medical services. The framework is then used to assess and compare the effectiveness of differing approaches. In particular, the American and British experiences of litigation, including the concept of 'defensive medicine', are evaluated. Also discussed briefly are alternatives to court-based complaints procedures including 'no-fault' schemes, professional ethics and internal complaints mechanisms. PMID:3392721

The limits to cumulative causation: international migration from Mexican urban areas.

PubMed

Fussell, Elizabeth; Massey, Douglas S

2004-02-01

We present theoretical arguments and empirical research to suggest that the principal mechanisms of cumulative causation do not function in large urban settings. Using data from the Mexican Migration Project, we found evidence of cumulative causation in small cities, rural towns and villages, but not in large urban areas. With event-history models, we found little positive effect of community-level social capital and a strong deterrent effect of urban labor markets on the likelihood of first and later U.S. trips for residents of urban areas in Mexico, suggesting that the social process of migration from urban areas is distinct from that in the more widely studied rural migrant-sending communities of Mexico.

An applied test of the social learning theory of deviance to college alcohol use.

PubMed

DeMartino, Cynthia H; Rice, Ronald E; Saltz, Robert

2015-04-01

Several hypotheses about influences on college drinking derived from the social learning theory of deviance were tested and confirmed. The effect of ethnicity on alcohol use was completely mediated by differential association and differential reinforcement, whereas the effect of biological sex on alcohol use was partially mediated. Higher net positive reinforcements to costs for alcohol use predicted increased general use, more underage use, and more frequent binge drinking. Two unexpected finding were the negative relationship between negative expectations and negative experiences, and the substantive difference between nondrinkers and general drinkers compared with illegal or binge drinkers. The discussion considers implications for future campaigns based on Akers's deterrence theory.

Deterrence of the drinking driver : an international survey

DOT National Transportation Integrated Search

1981-03-01

The report surveys the international literature on drinking-and-driving laws to determine what is known concerning their impact on driver behavior. Its particular concern is with reported adoptions of Scandinavian-type laws, which define the drinking...

Prevention and Deterrence of Crimes Against Children Act of 2009

THOMAS, 111th Congress

Rep. Scalise, Steve [R-LA-1

2009-07-31

House - 09/14/2009 Referred to the Subcommittee on Immigration, Citizenship, Refugees, Border Security, and International Law. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

NNSA Administrator Looks to Future of Nuclear Security at STRATCOM Symposium

ScienceCinema

Thomas D'Agostino

2017-12-09

Administrator Thomas P. DAgostino of the National Nuclear Security Administration (NNSA) discusses the future of the Nuclear Security Enterprise and its strategic deterrence mission in light of President Obamas unprecedented nuclear security agenda.

Bird nesting and droppings control on highway structures.

DOT National Transportation Integrated Search

2010-10-01

This report provides a comprehensive literature survey of permanent and temporary deterrents to nesting and roosting, a : discussion of risks to human health and safety from exposure to bird nests and droppings and recommended protective measures, : ...

Facing Up to the Issues.

ERIC Educational Resources Information Center

Wakefield, Rowan; And Others

1984-01-01

Major long-term issues that will have to be addressed by the president and Congress are discussed. These include the changing American family, America's growing international debt, changing trends in agribusiness, industrial policy, and nuclear weapons and strategic deterrence. (RM)

Crash test and evaluation of locking architectural mailboxes.

DOT National Transportation Integrated Search

2014-09-01

Some homeowners and businesses are becoming increasingly concerned about mail-identity theft. : Consequently, there is a growing demand for the use of locking mailboxes for theft deterrence and vandal : resistance. There are a number of mailbox produ...

48 CFR 32.107 - Need for contract financing not a deterrent.

Code of Federal Regulations, 2011 CFR

2011-10-01

... contractor's need for contract financing as a handicap for a contract award; e.g., as a responsibility factor... because the contractor failed to indicate a need for contract financing before the contract was awarded. ...

48 CFR 32.107 - Need for contract financing not a deterrent.

Code of Federal Regulations, 2012 CFR

2012-10-01

... contractor's need for contract financing as a handicap for a contract award; e.g., as a responsibility factor... because the contractor failed to indicate a need for contract financing before the contract was awarded. ...

48 CFR 32.107 - Need for contract financing not a deterrent.

Code of Federal Regulations, 2014 CFR

2014-10-01

... contractor's need for contract financing as a handicap for a contract award; e.g., as a responsibility factor... because the contractor failed to indicate a need for contract financing before the contract was awarded. ...

48 CFR 32.107 - Need for contract financing not a deterrent.

Code of Federal Regulations, 2010 CFR

2010-10-01

... contractor's need for contract financing as a handicap for a contract award; e.g., as a responsibility factor... because the contractor failed to indicate a need for contract financing before the contract was awarded. ...

48 CFR 32.107 - Need for contract financing not a deterrent.

Code of Federal Regulations, 2013 CFR

2013-10-01

... contractor's need for contract financing as a handicap for a contract award; e.g., as a responsibility factor... because the contractor failed to indicate a need for contract financing before the contract was awarded. ...

Deterrence and transmission as mechanisms ensuring reliability of gossip.

PubMed

Giardini, Francesca

2012-10-01

Spreading information about the members of one's group is one of the most universal human behaviors. Thanks to gossip, individuals can acquire the information about their peers without sustaining the burden of costly interactions with cheaters, but they can also create and revise social bonds. Gossip has also several positive functions at the group level, promoting cohesion and norm compliance. However, gossip can be unreliable, and can be used to damage others' reputation or to circulate false information, thus becoming detrimental to people involved and useless for the group. In this work, we propose a theoretical model in which reliability of gossip depends on the joint functioning of two distinct mechanisms. Thanks to the first, i.e., deterrence, individuals tend to avoid informational cheating because they fear punishment and the disruption of social bonds. On the other hand, transmission provides humans with the opportunity of reducing the consequences of cheating through a manipulation of the source of gossip.