A General Audiovisual Temporal Processing Deficit in Adult Readers With Dyslexia.

PubMed

Francisco, Ana A; Jesse, Alexandra; Groen, Margriet A; McQueen, James M

2017-01-01

Because reading is an audiovisual process, reading impairment may reflect an audiovisual processing deficit. The aim of the present study was to test the existence and scope of such a deficit in adult readers with dyslexia. We tested 39 typical readers and 51 adult readers with dyslexia on their sensitivity to the simultaneity of audiovisual speech and nonspeech stimuli, their time window of audiovisual integration for speech (using incongruent /aCa/ syllables), and their audiovisual perception of phonetic categories. Adult readers with dyslexia showed less sensitivity to audiovisual simultaneity than typical readers for both speech and nonspeech events. We found no differences between readers with dyslexia and typical readers in the temporal window of integration for audiovisual speech or in the audiovisual perception of phonetic categories. The results suggest an audiovisual temporal deficit in dyslexia that is not specific to speech-related events. But the differences found for audiovisual temporal sensitivity did not translate into a deficit in audiovisual speech perception. Hence, there seems to be a hiatus between simultaneity judgment and perception, suggesting a multisensory system that uses different mechanisms across tasks. Alternatively, it is possible that the audiovisual deficit in dyslexia is only observable when explicit judgments about audiovisual simultaneity are required.

Oscillatory integration windows in neurons

PubMed Central

Gupta, Nitin; Singh, Swikriti Saran; Stopfer, Mark

2016-01-01

Oscillatory synchrony among neurons occurs in many species and brain areas, and has been proposed to help neural circuits process information. One hypothesis states that oscillatory input creates cyclic integration windows: specific times in each oscillatory cycle when postsynaptic neurons become especially responsive to inputs. With paired local field potential (LFP) and intracellular recordings and controlled stimulus manipulations we directly test this idea in the locust olfactory system. We find that inputs arriving in Kenyon cells (KCs) sum most effectively in a preferred window of the oscillation cycle. With a computational model, we show that the non-uniform structure of noise in the membrane potential helps mediate this process. Further experiments performed in vivo demonstrate that integration windows can form in the absence of inhibition and at a broad range of oscillation frequencies. Our results reveal how a fundamental coincidence-detection mechanism in a neural circuit functions to decode temporally organized spiking. PMID:27976720

Temporal windows in visual processing: "prestimulus brain state" and "poststimulus phase reset" segregate visual transients on different temporal scales.

PubMed

Wutz, Andreas; Weisz, Nathan; Braun, Christoph; Melcher, David

2014-01-22

Dynamic vision requires both stability of the current perceptual representation and sensitivity to the accumulation of sensory evidence over time. Here we study the electrophysiological signatures of this intricate balance between temporal segregation and integration in vision. Within a forward masking paradigm with short and long stimulus onset asynchronies (SOA), we manipulated the temporal overlap of the visual persistence of two successive transients. Human observers enumerated the items presented in the second target display as a measure of the informational capacity read-out from this partly temporally integrated visual percept. We observed higher β-power immediately before mask display onset in incorrect trials, in which enumeration failed due to stronger integration of mask and target visual information. This effect was timescale specific, distinguishing between segregation and integration of visual transients that were distant in time (long SOA). Conversely, for short SOA trials, mask onset evoked a stronger visual response when mask and targets were correctly segregated in time. Examination of the target-related response profile revealed the importance of an evoked α-phase reset for the segregation of those rapid visual transients. Investigating this precise mapping of the temporal relationships of visual signals onto electrophysiological responses highlights how the stream of visual information is carved up into discrete temporal windows that mediate between segregated and integrated percepts. Fragmenting the stream of visual information provides a means to stabilize perceptual events within one instant in time.

On the temporal window of auditory-brain system in connection with subjective responses

NASA Astrophysics Data System (ADS)

Mouri, Kiminori

2003-08-01

The human auditory-brain system processes information extracted from autocorrelation function (ACF) of the source signal and interaural cross correlation function (IACF) of binaural sound signals which are associated with the left and right cerebral hemispheres, respectively. The purpose of this dissertation is to determine the desirable temporal window (2T: integration interval) for ACF and IACF mechanisms. For the ACF mechanism, the visual change of Φ(0), i.e., the power of ACF, was associated with the change of loudness, and it is shown that the recommended temporal window is given as about 30(τe)min [s]. The value of (τe)min is the minimum value of effective duration of the running ACF of the source signal. It is worth noticing from the experiment of EEG that the most preferred delay time of the first reflection sound is determined by the piece indicating (τe)min in the source signal. For the IACF mechanism, the temporal window is determined as below: The measured range of τIACC corresponding to subjective angle for the moving image sound depends on the temporal window. Here, the moving image was simulated by the use of two loudspeakers located at +/-20° in the horizontal plane, reproducing amplitude modulated band-limited noise alternatively. It is found that the temporal window has a wide range of values from 0.03 to 1 [s] for the modulation frequency below 0.2 Hz. Thesis advisor: Yoichi Ando Copies of this thesis written in English can be obtained from Kiminori Mouri, 5-3-3-1110 Harayama-dai, Sakai city, Osaka 590-0132, Japan. E-mail address: km529756@aol.com

A test of multiple correlation temporal window characteristic of non-Markov processes

NASA Astrophysics Data System (ADS)

Arecchi, F. T.; Farini, A.; Megna, N.

2016-03-01

We introduce a sensitive test of memory effects in successive events. The test consists of a combination K of binary correlations at successive times. K decays monotonically from K = 1 for uncorrelated events as a Markov process. For a monotonic memory fading, K<1 always. Here we report evidence of a K>1 temporal window in cognitive tasks consisting of the visual identification of the front face of the Necker cube after a previous presentation of the same. We speculate that memory effects provide a temporal window with K>1 and this experiment could be a possible first step towards a better comprehension of this phenomenon. The K>1 behaviour is maximal at an inter-measurement time τ around 2s with inter-subject differences. The K>1 persists over a time window of 1s around τ; outside this window the K<1 behaviour is recovered. The universal occurrence of a K>1 window in pairs of successive perceptions suggests that, at variance with single visual stimuli eliciting a suitable response, a pair of stimuli shortly separated in time displays mutual correlations.

Behavioural evidence for separate mechanisms of audiovisual temporal binding as a function of leading sensory modality.

PubMed

Cecere, Roberto; Gross, Joachim; Thut, Gregor

2016-06-01

The ability to integrate auditory and visual information is critical for effective perception and interaction with the environment, and is thought to be abnormal in some clinical populations. Several studies have investigated the time window over which audiovisual events are integrated, also called the temporal binding window, and revealed asymmetries depending on the order of audiovisual input (i.e. the leading sense). When judging audiovisual simultaneity, the binding window appears narrower and non-malleable for auditory-leading stimulus pairs and wider and trainable for visual-leading pairs. Here we specifically examined the level of independence of binding mechanisms when auditory-before-visual vs. visual-before-auditory input is bound. Three groups of healthy participants practiced audiovisual simultaneity detection with feedback, selectively training on auditory-leading stimulus pairs (group 1), visual-leading stimulus pairs (group 2) or both (group 3). Subsequently, we tested for learning transfer (crossover) from trained stimulus pairs to non-trained pairs with opposite audiovisual input. Our data confirmed the known asymmetry in size and trainability for auditory-visual vs. visual-auditory binding windows. More importantly, practicing one type of audiovisual integration (e.g. auditory-visual) did not affect the other type (e.g. visual-auditory), even if trainable by within-condition practice. Together, these results provide crucial evidence that audiovisual temporal binding for auditory-leading vs. visual-leading stimulus pairs are independent, possibly tapping into different circuits for audiovisual integration due to engagement of different multisensory sampling mechanisms depending on leading sense. Our results have implications for informing the study of multisensory interactions in healthy participants and clinical populations with dysfunctional multisensory integration. © 2016 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

Improving Accuracy and Temporal Resolution of Learning Curve Estimation for within- and across-Session Analysis

PubMed Central

Tabelow, Karsten; König, Reinhard; Polzehl, Jörg

2016-01-01

Estimation of learning curves is ubiquitously based on proportions of correct responses within moving trial windows. Thereby, it is tacitly assumed that learning performance is constant within the moving windows, which, however, is often not the case. In the present study we demonstrate that violations of this assumption lead to systematic errors in the analysis of learning curves, and we explored the dependency of these errors on window size, different statistical models, and learning phase. To reduce these errors in the analysis of single-subject data as well as on the population level, we propose adequate statistical methods for the estimation of learning curves and the construction of confidence intervals, trial by trial. Applied to data from an avoidance learning experiment with rodents, these methods revealed performance changes occurring at multiple time scales within and across training sessions which were otherwise obscured in the conventional analysis. Our work shows that the proper assessment of the behavioral dynamics of learning at high temporal resolution can shed new light on specific learning processes, and, thus, allows to refine existing learning concepts. It further disambiguates the interpretation of neurophysiological signal changes recorded during training in relation to learning. PMID:27303809

Optimal pulse design for communication-oriented slow-light pulse detection.

PubMed

Stenner, Michael D; Neifeld, Mark A

2008-01-21

We present techniques for designing pulses for linear slow-light delay systems which are optimal in the sense that they maximize the signal-to-noise ratio (SNR) and signal-to-noise-plus-interference ratio (SNIR) of the detected pulse energy. Given a communication model in which input pulses are created in a finite temporal window and output pulse energy in measured in a temporally-offset output window, the SNIR-optimal pulses achieve typical improvements of 10 dB compared to traditional pulse shapes for a given output window offset. Alternatively, for fixed SNR or SNIR, window offset (detection delay) can be increased by 0.3 times the window width. This approach also invites a communication-based model for delay and signal fidelity.

Reducing Sensor Noise in MEG and EEG Recordings Using Oversampled Temporal Projection.

PubMed

Larson, Eric; Taulu, Samu

2018-05-01

Here, we review the theory of suppression of spatially uncorrelated, sensor-specific noise in electro- and magentoencephalography (EEG and MEG) arrays, and introduce a novel method for suppression. Our method requires only that the signals of interest are spatially oversampled, which is a reasonable assumption for many EEG and MEG systems. Our method is based on a leave-one-out procedure using overlapping temporal windows in a mathematical framework to project spatially uncorrelated noise in the temporal domain. This method, termed "oversampled temporal projection" (OTP), has four advantages over existing methods. First, sparse channel-specific artifacts are suppressed while limiting mixing with other channels, whereas existing linear, time-invariant spatial operators can spread such artifacts to other channels with a spatial distribution which can be mistaken for one produced by an electrophysiological source. Second, OTP minimizes distortion of the spatial configuration of the data. During source localization (e.g., dipole fitting), many spatial methods require corresponding modification of the forward model to avoid bias, while OTP does not. Third, noise suppression factors at the sensor level are maintained during source localization, whereas bias compensation removes the denoising benefit for spatial methods that require such compensation. Fourth, OTP uses a time-window duration parameter to control the tradeoff between noise suppression and adaptation to time-varying sensor characteristics. OTP efficiently optimizes noise suppression performance while controlling for spatial bias of the signal of interest. This is important in applications where sensor noise significantly limits the signal-to-noise ratio, such as high-frequency brain oscillations.

Lamb Temporal Bone as a Surgical Training Model of Round Window Cochlear Implant Electrode Insertion.

PubMed

Mantokoudis, Georgios; Huth, Markus E; Weisstanner, Christian; Friedrich, Hergen M; Nauer, Claude; Candreia, Claudia; Caversaccio, Marco D; Senn, Pascal

2016-01-01

The preservation of residual hearing in cochlear implantation opens the door for optimal functional results. This atraumatic surgical technique requires training; however, the traditional human cadaveric temporal bones have become less available or unattainable in some institutions. This study investigates the suitability of an alternative model, using cadaveric lamb temporal bone, for surgical training of atraumatic round window electrode insertion. A total of 14 lamb temporal bones were dissected for cochlear implantation by four surgeons. After mastoidectomy, visualization, and drilling of the round window niche, an atraumatic round window insertion of a Medel Flex24 electrode was performed. Electrode insertion depth and position were verified by computed tomography scans. All cochleas were successfully implanted using the atraumatic round window approach; however, surgical access through the mastoid was substantially different when compared human anatomy. The mean number of intracochlear electrode contacts was 6.5 (range, 4-11) and the mean insertion depth 10.4 mm (range, 4-20 mm), which corresponds to a mean angular perimodiolar insertion depth of 229 degrees (range 67-540°). Full insertion of the electrode was not possible because of the smaller size of the lamb cochlea in comparison to that of the human. The lamb temporal bone model is well suited as a training model for atraumatic cochlear implantation at the level of the round window. The minimally pneumatized mastoid as well as the smaller cochlea can help prepare a surgeon for difficult cochlear implantations. Because of substantial differences to human anatomy, it is not an adequate training model for other surgical techniques such as mastoidectomy and posterior tympanotomy as well as full electrode insertion.

Masking Period Patterns and Forward Masking for Speech-Shaped Noise: Age-Related Effects.

PubMed

Grose, John H; Menezes, Denise C; Porter, Heather L; Griz, Silvana

2016-01-01

The purpose of this study was to assess age-related changes in temporal resolution in listeners with relatively normal audiograms. The hypothesis was that increased susceptibility to nonsimultaneous masking contributes to the hearing difficulties experienced by older listeners in complex fluctuating backgrounds. Participants included younger (n = 11), middle-age (n = 12), and older (n = 11) listeners with relatively normal audiograms. The first phase of the study measured masking period patterns for speech-shaped noise maskers and signals. From these data, temporal window shapes were derived. The second phase measured forward-masking functions and assessed how well the temporal window fits accounted for these data. The masking period patterns demonstrated increased susceptibility to backward masking in the older listeners, compatible with a more symmetric temporal window in this group. The forward-masking functions exhibited an age-related decline in recovery to baseline thresholds, and there was also an increase in the variability of the temporal window fits to these data. This study demonstrated an age-related increase in susceptibility to nonsimultaneous masking, supporting the hypothesis that exacerbated nonsimultaneous masking contributes to age-related difficulties understanding speech in fluctuating noise. Further support for this hypothesis comes from limited speech-in-noise data, suggesting an association between susceptibility to forward masking and speech understanding in modulated noise.

Pheromone responsiveness threshold depends on temporal integration by antennal lobe projection neurons

PubMed Central

Tabuchi, Masashi; Sakurai, Takeshi; Mitsuno, Hidefumi; Namiki, Shigehiro; Minegishi, Ryo; Shiotsuki, Takahiro; Uchino, Keiro; Sezutsu, Hideki; Tamura, Toshiki; Haupt, Stephan Shuichi; Nakatani, Kei; Kanzaki, Ryohei

2013-01-01

The olfactory system of male moths has an extreme sensitivity with the capability to detect and recognize conspecific pheromones dispersed and greatly diluted in the air. Just 170 molecules of the silkmoth (Bombyx mori) sex pheromone bombykol are sufficient to induce sexual behavior in the male. However, it is still unclear how the sensitivity of olfactory receptor neurons (ORNs) is relayed through the brain to generate high behavioral responsiveness. Here, we show that ORN activity that is subthreshold in terms of behavior can be amplified to suprathreshold levels by temporal integration in antennal lobe projection neurons (PNs) if occurring within a specific time window. To control ORN inputs with high temporal resolution, channelrhodopsin-2 was genetically introduced into bombykol-responsive ORNs. Temporal integration in PNs was only observed for weak inputs, but not for strong inputs. Pharmacological dissection revealed that GABAergic mechanisms inhibit temporal integration of strong inputs, showing that GABA signaling regulates PN responses in a stimulus-dependent fashion. Our results show that boosting of the PNs’ responses by temporal integration of olfactory information occurs specifically near the behavioral threshold, effectively defining the lower bound for behavioral responsiveness. PMID:24006366

Window and Overlap Processing Effects on Power Estimates from Spectra

NASA Astrophysics Data System (ADS)

Trethewey, M. W.

2000-03-01

Fast Fourier transform (FFT) spectral processing is based on the assumption of stationary ergodic data. In engineering practice, the assumption is often violated and non-stationary data processed. Data windows are commonly used to reduce leakage by decreasing the signal amplitudes near the boundaries of the discrete samples. With certain combinations of non-stationary signals and windows, the temporal weighting may attenuate important signal characteristics to adversely affect any subsequent processing. In other words, the window artificially reduces a significant section of the time signal. Consequently, spectra and overall power estimated from the affected samples are unreliable. FFT processing can be particularly problematic when the signal consists of randomly occurring transients superimposed on a more continuous signal. Overlap processing is commonly used in this situation to improve the estimates. However, the results again depend on the temporal character of the signal in relation to the window weighting. A worst-case scenario, a short-duration half sine pulse, is used to illustrate the relationship between overlap percentage and resulting power estimates. The power estimates are shown to depend on the temporal behaviour of the square of overlapped window segments. An analysis shows that power estimates may be obtained to within 0.27 dB for the following windows and overlap combinations: rectangular (0% overlap), Hanning (62.5% overlap), Hamming (60.35% overlap) and flat-top (82.25% overlap).

Duration of ultrasound-mediated enhanced plasma membrane permeability.

PubMed

Lammertink, Bart; Deckers, Roel; Storm, Gert; Moonen, Chrit; Bos, Clemens

2015-03-30

Ultrasound (US) induced cavitation can be used to enhance the intracellular delivery of drugs by transiently increasing the cell membrane permeability. The duration of this increased permeability, termed temporal window, has not been fully elucidated. In this study, the temporal window was investigated systematically using an endothelial- and two breast cancer cell lines. Model drug uptake was measured as a function of time after sonication, in the presence of SonoVue™ microbubbles, in HUVEC, MDA-MB-468 and 4T1 cells. In addition, US pressure amplitude was varied in MDA-MB-468 cells to investigate its effect on the temporal window. Cell membrane permeability of HUVEC and MDA-MB-468 cells returned to control level within 1-2 h post-sonication, while 4T1 cells needed over 3h. US pressure affected the number of cells with increased membrane permeability, as well as the temporal window in MDA-MB-468 cells. This study shows that the duration of increased membrane permeability differed between the cell lines and US pressures used here. However, all were consistently in the order of 1-3 h after sonication. Copyright © 2014 Elsevier B.V. All rights reserved.

An Evaluation of the Surgical Trauma to Intracochlear Structures After Insertion of Cochlear Implant Electrode Arrays: A Comparison by Round Window and Antero-Inferior Cochleostomy Techniques.

PubMed

Sikka, Kapil; Kairo, Arvind; Singh, Chirom Amit; Roy, T S; Lalwani, Sanjeev; Kumar, Rakesh; Thakar, Alok; Sharma, Suresh C

2017-09-01

To evaluate the extent of intracochlear damage by histologic assessment of cadaveric temporal bones after insertion of cochlear implants by: round window approach and cochleostomy approach. Cochlear implantation was performed by transmastoid facial recess approach in 10 human cadaveric temporal bones. In 5 temporal bones, electrode insertion was acheieved by round window approach and in the remaining 5 bones, by cochleostomy approach. The bones were fixed, decalcified, sectioned and studied histologically. Grading of insertion trauma was assessed. In the round window insertion group, 2 bones had to be excluded from the study: one was damaged during handling with electrode extrusion and another bone did not show any demonstrable identifiable cochlear structure. Out of the 3 temporal bones, a total of 35 sections were examined: 24 demonstrated normal cochlea, 4 had basilar membrane bulging and 7 had fracture of bony spiral lamina. In the cochleostomy group, histology of 2 bones had to be discarded due to lack of any identifiable inner ear structures. Out of the 3 bones studied, 18 sections were examined: only 3 were normal, 4 sections had some bulge in spiral lamina and 11 had fracture of bony spiral lamina. The fracture of spiral lamina and bulge of basement membrane proportion is relatively higher if we perform cochleostomy as compared to round window approach. Therefore, round window insertion is relatively less traumatic as compared to cochleostomy. However, our sample size was very small and a study with a larger sample is required to further validate these findings.

Mechanisms for Rapid Adaptive Control of Motion Processing in Macaque Visual Cortex.

PubMed

McLelland, Douglas; Baker, Pamela M; Ahmed, Bashir; Kohn, Adam; Bair, Wyeth

2015-07-15

A key feature of neural networks is their ability to rapidly adjust their function, including signal gain and temporal dynamics, in response to changes in sensory inputs. These adjustments are thought to be important for optimizing the sensitivity of the system, yet their mechanisms remain poorly understood. We studied adaptive changes in temporal integration in direction-selective cells in macaque primary visual cortex, where specific hypotheses have been proposed to account for rapid adaptation. By independently stimulating direction-specific channels, we found that the control of temporal integration of motion at one direction was independent of motion signals driven at the orthogonal direction. We also found that individual neurons can simultaneously support two different profiles of temporal integration for motion in orthogonal directions. These findings rule out a broad range of adaptive mechanisms as being key to the control of temporal integration, including untuned normalization and nonlinearities of spike generation and somatic adaptation in the recorded direction-selective cells. Such mechanisms are too broadly tuned, or occur too far downstream, to explain the channel-specific and multiplexed temporal integration that we observe in single neurons. Instead, we are compelled to conclude that parallel processing pathways are involved, and we demonstrate one such circuit using a computer model. This solution allows processing in different direction/orientation channels to be separately optimized and is sensible given that, under typical motion conditions (e.g., translation or looming), speed on the retina is a function of the orientation of image components. Many neurons in visual cortex are understood in terms of their spatial and temporal receptive fields. It is now known that the spatiotemporal integration underlying visual responses is not fixed but depends on the visual input. For example, neurons that respond selectively to motion direction integrate signals over a shorter time window when visual motion is fast and a longer window when motion is slow. We investigated the mechanisms underlying this useful adaptation by recording from neurons as they responded to stimuli moving in two different directions at different speeds. Computer simulations of our results enabled us to rule out several candidate theories in favor of a model that integrates across multiple parallel channels that operate at different time scales. Copyright © 2015 the authors 0270-6474/15/3510268-13$15.00/0.

Longitudinal positron emission tomography imaging of glial cell activation in a mouse model of mesial temporal lobe epilepsy: Toward identification of optimal treatment windows.

PubMed

Nguyen, Duc-Loc; Wimberley, Catriona; Truillet, Charles; Jego, Benoit; Caillé, Fabien; Pottier, Géraldine; Boisgard, Raphaël; Buvat, Irène; Bouilleret, Viviane

2018-06-01

Mesiotemporal lobe epilepsy is the most common type of drug-resistant partial epilepsy, with a specific history that often begins with status epilepticus due to various neurological insults followed by a silent period. During this period, before the first seizure occurs, a specific lesion develops, described as unilateral hippocampal sclerosis (HS). It is still challenging to determine which drugs, administered at which time point, will be most effective during the formation of this epileptic process. Neuroinflammation plays an important role in pathophysiological mechanisms in epilepsy, and therefore brain inflammation biomarkers such as translocator protein 18 kDa (TSPO) can be potent epilepsy biomarkers. TSPO is associated with reactive astrocytes and microglia. A unilateral intrahippocampal kainate injection mouse model can reproduce the defining features of human temporal lobe epilepsy with unilateral HS and the pattern of chronic pharmacoresistant temporal seizures. We hypothesized that longitudinal imaging using TSPO positron emission tomography (PET) with 18 F-DPA-714 could identify optimal treatment windows in a mouse model during the formation of HS. The model was induced into the right dorsal hippocampus of male C57/Bl6 mice. Micro-PET/computed tomographic scanning was performed before model induction and along the development of the HS at 7 days, 14 days, 1 month, and 6 months. In vitro autoradiography and immunohistofluorescence were performed on additional mice at each time point. TSPO PET uptake reached peak at 7 days and mostly related to microglial activation, whereas after 14 days, reactive astrocytes were shown to be the main cells expressing TSPO, reflected by a continuing increased PET uptake. TSPO-targeted PET is a highly potent longitudinal biomarker of epilepsy and could be of interest to determine the therapeutic windows in epilepsy and to monitor response to treatment. Wiley Periodicals, Inc. © 2018 International League Against Epilepsy.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, L; Shen, C; Wang, J

Purpose: To reduce cone beam CT (CBCT) imaging dose, we previously proposed a progressive dose control (PDC) scheme to employ temporal correlation between CBCT images at different fractions for image quality enhancement. A temporal non-local means (TNLM) method was developed to enhance quality of a new low-dose CBCT using existing high-quality CBCT. To enhance a voxel value, the TNLM method searches for similar voxels in a window. Due to patient deformation among the two CBCTs, a large searching window was required, reducing image quality and computational efficiency. This abstract proposes a deformation-assisted TNLM (DA-TNLM) method to solve this problem. Methods:more » For a low-dose CBCT to be enhanced using a high-quality CBCT, we first performed deformable image registration between the low-dose CBCT and the high-quality CBCT to approximately establish voxel correspondence between the two. A searching window for a voxel was then set based on the deformation vector field. Specifically, the search window for each voxel was shifted by the deformation vector. A TNLM step was then applied using only voxels within this determined window to correct image intensity at the low-dose CBCT. Results: We have tested the proposed scheme on simulated CIRS phantom data and real patient data. The CITS phantom was scanned on Varian onboard imaging CBCT system with coach shifting and dose reducing for each time. The real patient data was acquired in four fractions with dose reduced from standard CBCT dose to 12.5% of standard dose. It was found that the DA-TNLM method can reduce total dose by over 75% on average in the first four fractions. Conclusion: We have developed a PDC scheme which can enhance the quality of image scanned at low dose using a DA-TNLM method. Tests in phantom and patient studies demonstrated promising results.« less

Masking Period Patterns & Forward Masking for Speech-Shaped Noise: Age-related effects

PubMed Central

Grose, John H.; Menezes, Denise C.; Porter, Heather L.; Griz, Silvana

2015-01-01

Objective The purpose of this study was to assess age-related changes in temporal resolution in listeners with relatively normal audiograms. The hypothesis was that increased susceptibility to non-simultaneous masking contributes to the hearing difficulties experienced by older listeners in complex fluctuating backgrounds. Design Participants included younger (n = 11), middle-aged (n = 12), and older (n = 11) listeners with relatively normal audiograms. The first phase of the study measured masking period patterns for speech-shaped noise maskers and signals. From these data, temporal window shapes were derived. The second phase measured forward-masking functions, and assessed how well the temporal window fits accounted for these data. Results The masking period patterns demonstrated increased susceptibility to backward masking in the older listeners, compatible with a more symmetric temporal window in this group. The forward-masking functions exhibited an age-related decline in recovery to baseline thresholds, and there was also an increase in the variability of the temporal window fits to these data. Conclusions This study demonstrated an age-related increase in susceptibility to non-simultaneous masking, supporting the hypothesis that exacerbated non-simultaneous masking contributes to age-related difficulties understanding speech in fluctuating noise. Further support for this hypothesis comes from limited speech-in-noise data suggesting an association between susceptibility to forward masking and speech understanding in modulated noise. PMID:26230495

The Construct of the Multisensory Temporal Binding Window and its Dysregulation in Developmental Disabilities

PubMed Central

Wallace, Mark T.; Stevenson, Ryan A.

2014-01-01

Behavior, perception and cognition are strongly shaped by the synthesis of information across the different sensory modalities. Such multisensory integration often results in performance and perceptual benefits that reflect the additional information conferred by having cues from multiple senses providing redundant or complementary information. The spatial and temporal relationships of these cues provide powerful statistical information about how these cues should be integrated or “bound” in order to create a unified perceptual representation. Much recent work has examined the temporal factors that are integral in multisensory processing, with many focused on the construct of the multisensory temporal binding window – the epoch of time within which stimuli from different modalities is likely to be integrated and perceptually bound. Emerging evidence suggests that this temporal window is altered in a series of neurodevelopmental disorders, including autism, dyslexia and schizophrenia. In addition to their role in sensory processing, these deficits in multisensory temporal function may play an important role in the perceptual and cognitive weaknesses that characterize these clinical disorders. Within this context, focus on improving the acuity of multisensory temporal function may have important implications for the amelioration of the “higher-order” deficits that serve as the defining features of these disorders. PMID:25128432

Temporal Binding Window of the Sound-Induced Flash Illusion in Amblyopia.

PubMed

Narinesingh, Cindy; Goltz, Herbert C; Wong, Agnes M F

2017-03-01

Amblyopia is a neurodevelopmental visual disorder caused by abnormal visual experience in childhood. In addition to known visual deficits, there is evidence for changes in audiovisual integration in amblyopia using explicit tasks. We examined audiovisual integration in amblyopia using an implicit task that is more relevant in a real-world context. A total of 11 participants with amblyopia and 16 controls were tested binocularly and monocularly on the sound-induced flash illusion, in which flashes and beeps are presented concurrently and the perceived number of flashes is influenced by the number of beeps. The task used 1 to 2 rapid peripheral flashes presented with 0 to 2 beeps, at 5 stimulus onset asynchronies, that is, beep (-200 milliseconds, -100 milliseconds) or flash leading (100 milliseconds, 200 milliseconds) or simultaneous (0 milliseconds). Participants reported the number of perceived flashes. Susceptibility was indicated by a "2 flashes" response to "fission" (1 flash, 2 beeps) or "1 flash" to "fusion" (2 flashes, 1 beep). For fission with the beep leading during binocular viewing, controls showed an expected decrease in illusion strength as stimulus onset asynchronies increased, whereas the illusion strength remained constant in participants with amblyopia, indicating a wider temporal binding window in amblyopia (P = 0.007). For fusion, participants with amblyopia showed reduced illusion strength during amblyopic eye viewing (P = 0.044) with the flash leading. Amblyopia is associated with the widening of the temporal binding window, specifically for fission when viewing binocularly with the beep leading. This suggests a developmental adaptation to delayed amblyopic eye visual processing to optimize audiovisual integration.

[Applied anatomy of scala tympani inlet related to cochlear implantation].

PubMed

Zou, Tuanming; Guo, Menghe; Zhang, Hongzheng; Shu, Fan; Xie, Nanping

2012-06-01

To investigate the related parameters of the temporal bone structure for determining the position of implanting electrode into the scala tympani in cochlear implantation surgery through the facial recess and epitympanum approach. In a surgical simulation experiment, 20 human temporal bones were studied and measured to determine the related parameters of the temporal bone structure. The distance 5.91∓0.29 mm between the short process of the incus and the round window niche, 2.11∓0.18 mm between the stapes and the round window niche, 6.70∓0.19 mm between the facial nerve in the perpendicular paragraph and the round window niche, 2.22∓0.21 mm from the pyramidal eminence to the round window, and 2.16∓0.14 mm between the stapes and the round window. The minimal distance between the implanting electrode and the vestibular window was 2.12∓0.19 mm. The distance between the cochleariform process and the round window niche was 3.79∓0.17 mm. The position of the cochlear electrode array insertion into the second cochlear turn was 2.25∓0.13 mm under the stapes. The location of the cochlear electrode array insertion into the second cochlear turn was 2.28∓0.20 mm inferior to the pyramidal eminence. These parameters provide a reference value to determine the different positions of cochlear electrode array insertion into the scale tympani in different patients.

Measurement of stapes vibration in Human temporal bones by round window stimulation using a 3-coil transducer.

PubMed

Shin, Dong Ho; Kim, Dong Wook; Lim, Hyung Gyu; Jung, Eui Sung; Seong, Ki Woong; Lee, Jyung Hyun; Kim, Myoung Nam; Cho, Jin Ho

2014-01-01

Round window placement of a 3-coil transducer offers a new approach for coupling an implantable hearing aid to the inner ear. The transducer exhibits high performance at low-frequencies. One remarkable feature of the 3-coil transducer is that it minimizes leakage flux. Thus, the transducer, which consists of two permanent magnets and three coils, can enhance vibrational displacement. In human temporal bones, stapes vibration was observed by laser Doppler vibrometer in response to round window stimulation using the 3-coil transducer. Coupling between the 3-coil transducer and the round window was connected by a wire-rod. The stimulation created stapes velocity when the round window stimulated. Performance evaluation was conducted by measuring stapes velocity. To verify the performance of the 3-coil transducer, stapes velocity for round window and tympanic membrane stimulation were compared, respectively. Stapes velocity by round window stimulation using the 3-coil transducer was approximately 14 dB higher than that achieved by tympanic membrane stimulation. The study shows that 3-coil transducer is suitable for implantable hearing aids.

The effect of length and starting year on trend analyses of temperatures in Spanish mainland (1951-2010). Seasonal analyses: Spring (III)

NASA Astrophysics Data System (ADS)

Salinas Solé, Celia; Peña Angulo, Dhais; Gonzalez Hidalgo, Jose Carlos; Brunetti, Michele

2017-04-01

In this poster we applied the moving window approach (see Poster I of this collection) to analyze trends of spring and its corresponding months (March, April, May) temperature mean values of maximum (Tmax) and minimum (Tmin) in Spanish mainland to detect the effects of length period and starting year. Monthly series belong to Monthly Temperature dataset of Spanish mainland (MOTEDAS). Database contains in its grid format of 5236 pixels of monthly series (10x10 km). The threshold used in spatial analyses considers 20% of land under significant trend (p<0.05). The most striking results are as follow: • Seasonal Tmax shows that global trend was positive and significant until the mid 80's with higher values than 75% from between 1954-2010 to 1979-2010, being reduced after to the north region. So, from 1985-2010 no significant trend have been detected. Monthly analyses show differences. March trend is not significant (<20% of area) since 1974-2010, while significant trend in April and May varies between 1961-2010/1979-2010 and 1965-2010/1980-2010 respectively, clearly located in northern midland and Mediterranean coastland. • Spring Tmin trend analyses is significantly (>20%) during all temporal windows, notwithstanding NW do not show global significant trend, and in the most recent temporal windows only affect significantly SE. Monthly analyses also differ. Not significant trend is detected in March from 1979-2010, and from 1985-2010 in May, being April the month in any temporal windows with more than 20% of land affected by significant trend. • Spatial differences are detected between windows (South-North in March, East-West in April-May. We can conclude Tmax trend varies accordingly temporal windows dramatically in spring and no significance has been detected in the recent decades. Northern areas and Mediterranean coastland seems to be the most affected. Monthy Tmax trend spatial analyses confirm the heterogeneity of diurnal temperatures; different spatial gradients in windows have been detected between months. Seasonal Tmin show a more global temporal pattern. Spatial gradients of significance between months have been detected, in some sense contraries to the observed in Tmax.

Spatial-temporal modeling of the association between air pollution exposure and preterm birth: identifying critical windows of exposure.

PubMed

Warren, Joshua; Fuentes, Montserrat; Herring, Amy; Langlois, Peter

2012-12-01

Exposure to high levels of air pollution during the pregnancy is associated with increased probability of preterm birth (PTB), a major cause of infant morbidity and mortality. New statistical methodology is required to specifically determine when a particular pollutant impacts the PTB outcome, to determine the role of different pollutants, and to characterize the spatial variability in these results. We develop a new Bayesian spatial model for PTB which identifies susceptible windows throughout the pregnancy jointly for multiple pollutants (PM(2.5) , ozone) while allowing these windows to vary continuously across space and time. We geo-code vital record birth data from Texas (2002-2004) and link them with standard pollution monitoring data and a newly introduced EPA product of calibrated air pollution model output. We apply the fully spatial model to a region of 13 counties in eastern Texas consisting of highly urban as well as rural areas. Our results indicate significant signal in the first two trimesters of pregnancy with different pollutants leading to different critical windows. Introducing the spatial aspect uncovers critical windows previously unidentified when space is ignored. A proper inference procedure is introduced to correctly analyze these windows. © 2012, The International Biometric Society.

Vibration measurement by temporal Fourier analyses of a digital hologram sequence.

PubMed

Fu, Yu; Pedrini, Giancarlo; Osten, Wolfgang

2007-08-10

A method for whole-field noncontact measurement of displacement, velocity, and acceleration of a vibrating object based on image-plane digital holography is presented. A series of digital holograms of a vibrating object are captured by use of a high-speed CCD camera. The result of the reconstruction is a three-dimensional complex-valued matrix with noise. We apply Fourier analysis and windowed Fourier analysis in both the spatial and the temporal domains to extract the displacement, the velocity, and the acceleration. The instantaneous displacement is obtained by temporal unwrapping of the filtered phase map, whereas the velocity and acceleration are evaluated by Fourier analysis and by windowed Fourier analysis along the time axis. The combination of digital holography and temporal Fourier analyses allows for evaluation of the vibration, without a phase ambiguity problem, and smooth spatial distribution of instantaneous displacement, velocity, and acceleration of each instant are obtained. The comparison of Fourier analysis and windowed Fourier analysis in velocity and acceleration measurements is also presented.

Measuring temporal summation in visual detection with a single-photon source.

PubMed

Holmes, Rebecca; Victora, Michelle; Wang, Ranxiao Frances; Kwiat, Paul G

2017-11-01

Temporal summation is an important feature of the visual system which combines visual signals that arrive at different times. Previous research estimated complete summation to last for 100ms for stimuli judged "just detectable." We measured the full range of temporal summation for much weaker stimuli using a new paradigm and a novel light source, developed in the field of quantum optics for generating small numbers of photons with precise timing characteristics and reduced variance in photon number. Dark-adapted participants judged whether a light was presented to the left or right of their fixation in each trial. In Experiment 1, stimuli contained a stream of photons delivered at a constant rate while the duration was systematically varied. Accuracy should increase with duration as long as the later photons can be integrated with the proceeding ones into a single signal. The temporal integration window was estimated as the point that performance no longer improved, and was found to be 650ms on average. In Experiment 2, the duration of the visual stimuli was kept short (100ms or <30ms) while the number of photons was varied to explore the efficiency of summation over the integration window compared to Experiment 1. There was some indication that temporal summation remains efficient over the integration window, although there is variation between individuals. The relatively long integration window measured in this study may be relevant to studies of the absolute visual threshold, i.e., tests of single-photon vision, where "single" photons should be separated by greater than the integration window to avoid summation. Copyright © 2017 Elsevier Ltd. All rights reserved.

Predicting progression of mild cognitive impairment to dementia using neuropsychological data: a supervised learning approach using time windows.

PubMed

Pereira, Telma; Lemos, Luís; Cardoso, Sandra; Silva, Dina; Rodrigues, Ana; Santana, Isabel; de Mendonça, Alexandre; Guerreiro, Manuela; Madeira, Sara C

2017-07-19

Predicting progression from a stage of Mild Cognitive Impairment to dementia is a major pursuit in current research. It is broadly accepted that cognition declines with a continuum between MCI and dementia. As such, cohorts of MCI patients are usually heterogeneous, containing patients at different stages of the neurodegenerative process. This hampers the prognostic task. Nevertheless, when learning prognostic models, most studies use the entire cohort of MCI patients regardless of their disease stages. In this paper, we propose a Time Windows approach to predict conversion to dementia, learning with patients stratified using time windows, thus fine-tuning the prognosis regarding the time to conversion. In the proposed Time Windows approach, we grouped patients based on the clinical information of whether they converted (converter MCI) or remained MCI (stable MCI) within a specific time window. We tested time windows of 2, 3, 4 and 5 years. We developed a prognostic model for each time window using clinical and neuropsychological data and compared this approach with the commonly used in the literature, where all patients are used to learn the models, named as First Last approach. This enables to move from the traditional question "Will a MCI patient convert to dementia somewhere in the future" to the question "Will a MCI patient convert to dementia in a specific time window". The proposed Time Windows approach outperformed the First Last approach. The results showed that we can predict conversion to dementia as early as 5 years before the event with an AUC of 0.88 in the cross-validation set and 0.76 in an independent validation set. Prognostic models using time windows have higher performance when predicting progression from MCI to dementia, when compared to the prognostic approach commonly used in the literature. Furthermore, the proposed Time Windows approach is more relevant from a clinical point of view, predicting conversion within a temporal interval rather than sometime in the future and allowing clinicians to timely adjust treatments and clinical appointments.

CT findings of the temporal bone in CHARGE syndrome: aspects of importance in cochlear implant surgery.

PubMed

Vesseur, A C; Verbist, B M; Westerlaan, H E; Kloostra, F J J; Admiraal, R J C; van Ravenswaaij-Arts, C M A; Free, R H; Mylanus, E A M

2016-12-01

To provide an overview of anomalies of the temporal bone in CHARGE syndrome relevant to cochlear implantation (CI), anatomical structures of the temporal bone and the respective genotypes were analysed. In this retrospective study, 42 CTs of the temporal bone of 42 patients with CHARGE syndrome were reviewed in consensus by two head-and-neck radiologists and two otological surgeons. Anatomical structures of the temporal bone were evaluated and correlated with genetic data. Abnormalities that might affect CI surgery were seen, such as a vascular structure, a petrosquamosal sinus (13 %), an underdeveloped mastoid (8 %) and an aberrant course of the facial nerve crossing the round window (9 %) and/or the promontory (18 %). The appearance of the inner ear varied widely: in 77 % of patients all semicircular canals were absent and the cochlea varied from normal to hypoplastic. A stenotic cochlear aperture was observed in 37 %. The middle ear was often affected with a stenotic round (14 %) or oval window (71 %). More anomalies were observed in patients with truncating mutations than with non-truncating mutations. Temporal bone findings in CHARGE syndrome vary widely. Vascular variants, aberrant route of the facial nerve, an underdeveloped mastoid, aplasia of the semicircular canals, and stenotic round window may complicate cochlear implantation.

Regulation of Viable and Optimal Cohorts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aubin, Jean-Pierre, E-mail: aubin.jp@gmail.com

This study deals with the evolution of (scalar) attributes (resources or income in evolutionary demography or economics, position in traffic management, etc.) of a population of “mobiles” (economic agents, vehicles, etc.). The set of mobiles sharing the same attributes is regarded as an instantaneous cohort described by the number of its elements. The union of instantaneous cohorts during a mobile window between two attributes is a cohort. Given a measure defining the number of instantaneous cohorts, the accumulation of the mobile attributes on a evolving mobile window is the measure of the cohort on this temporal mobile window. Imposing accumulationmore » constraints and departure conditions, this study is devoted to the regulation of the evolutions of the attributes which are1.viable in the sense that the accumulations constraints are satisfied at each instant;2.and, among them, optimal, in the sense that both the duration of the temporal mobile window is maximum and that the accumulation on this temporal mobile window is the largest viable one. This value is the “accumulation valuation” function. Viable and optimal evolutions under accumulation constraints are regulated by an “implicit Volterra integro-differential inclusion” built from the accumulation valuation function, solution to an Hamilton–Jacobi–Bellman partial differential equation under constraints which is constructed for this purpose.« less

Shot boundary detection and label propagation for spatio-temporal video segmentation

NASA Astrophysics Data System (ADS)

Piramanayagam, Sankaranaryanan; Saber, Eli; Cahill, Nathan D.; Messinger, David

2015-02-01

This paper proposes a two stage algorithm for streaming video segmentation. In the first stage, shot boundaries are detected within a window of frames by comparing dissimilarity between 2-D segmentations of each frame. In the second stage, the 2-D segments are propagated across the window of frames in both spatial and temporal direction. The window is moved across the video to find all shot transitions and obtain spatio-temporal segments simultaneously. As opposed to techniques that operate on entire video, the proposed approach consumes significantly less memory and enables segmentation of lengthy videos. We tested our segmentation based shot detection method on the TRECVID 2007 video dataset and compared it with block-based technique. Cut detection results on the TRECVID 2007 dataset indicate that our algorithm has comparable results to the best of the block-based methods. The streaming video segmentation routine also achieves promising results on a challenging video segmentation benchmark database.

Physical activity classification with dynamic discriminative methods.

PubMed

Ray, Evan L; Sasaki, Jeffer E; Freedson, Patty S; Staudenmayer, John

2018-06-19

A person's physical activity has important health implications, so it is important to be able to measure aspects of physical activity objectively. One approach to doing that is to use data from an accelerometer to classify physical activity according to activity type (e.g., lying down, sitting, standing, or walking) or intensity (e.g., sedentary, light, moderate, or vigorous). This can be formulated as a labeled classification problem, where the model relates a feature vector summarizing the accelerometer signal in a window of time to the activity type or intensity in that window. These data exhibit two key characteristics: (1) the activity classes in different time windows are not independent, and (2) the accelerometer features have moderately high dimension and follow complex distributions. Through a simulation study and applications to three datasets, we demonstrate that a model's classification performance is related to how it addresses these aspects of the data. Dynamic methods that account for temporal dependence achieve better performance than static methods that do not. Generative methods that explicitly model the distribution of the accelerometer signal features do not perform as well as methods that take a discriminative approach to establishing the relationship between the accelerometer signal and the activity class. Specifically, Conditional Random Fields consistently have better performance than commonly employed methods that ignore temporal dependence or attempt to model the accelerometer features. © 2018, The International Biometric Society.

Preoperative evaluation of cochlear implantation through the round window membrane in the facial recess using high-resolution computed tomography.

PubMed

Xie, Li-Hong; Tang, Jie; Miao, Wen-Jie; Tang, Xiang-Long; Li, Heng; Tang, An-Zhou

2018-06-01

We evaluated the risk of cochlear implantation through the round window membrane in the facial recess through a preoperative analysis of the angle between the facial nerve-round window and the cranial midline using high-resolution temporal bone CT. Temporal bone CT films of 176 patients with profound sensorineural hearing loss at our hospital from 2013 to 2015 were reviewed. The preoperative temporal bone CT scans of the patients were retrospectively analysed. The vertical distance (d value) from the leading edge of the facial nerve to the posterior wall of the external auditory canal and the angle (α value) between the line from the leading edge of the facial nerve to the midpoint of the round window membrane and the median sagittal line on the round window membrane plane were measured. Based on intraoperative observation, the round window membrane was divided into complete round window membrane exposure (group A), partial exposure (group B), and unexposed (group C) groups, and statistical analysis was performed. The α value could be effectively measured for all 176 patients (62.60 ± 7.12), and the d value could be effectively measured for 95 cases (5.53 ± 1.00). An analysis of the correlation between the α and d values of these 95 cases found a negative correlation. Of the 176 cases, one-way analysis of variance (ANOVA) showed that the differences among the groups were significant [P = 0.000 (< 0.05)]. The angle (α value) between the line connecting the leading edge of the facial nerve to the midpoint of the round window and the median sagittal line measured in preoperative CT scans was associated with the difficulty of intraoperatively exposing the round window membrane. When the α value was larger than a certain degree, the difficulty of exposing the round window membrane was increased. In such cases, the surgeon should fully expose the round window membrane during surgery, which could result decrease the likelihood of complications.

Gender-specific effects of emotional modulation on visual temporal order thresholds.

PubMed

Liang, Wei; Zhang, Jiyuan; Bao, Yan

2015-09-01

Emotions affect temporal information processing in the low-frequency time window of a few seconds, but little is known about their effect in the high-frequency domain of some tens of milliseconds. The present study aims to investigate whether negative and positive emotional states influence the ability to discriminate the temporal order of visual stimuli, and whether gender plays a role in temporal processing. Due to the hemispheric lateralization of emotion, a hemispheric asymmetry between the left and the right visual field might be expected. Using a block design, subjects were primed with neutral, negative and positive emotional pictures before performing temporal order judgment tasks. Results showed that male subjects exhibited similarly reduced order thresholds under negative and positive emotional states, while female subjects demonstrated increased threshold under positive emotional state and reduced threshold under negative emotional state. Besides, emotions influenced female subjects more intensely than male subjects, and no hemispheric lateralization was observed. These observations indicate an influence of emotional states on temporal order processing of visual stimuli, and they suggest a gender difference, which is possibly associated with a different emotional stability.

Accounting for nonmonotonic precursor duration effects with gain reduction in the temporal window model.

PubMed

Roverud, Elin; Strickland, Elizabeth A

2014-03-01

The mechanisms of forward masking are not clearly understood. The temporal window model (TWM) proposes that masking occurs via a neural mechanism that integrates within a temporal window. The medial olivocochlear reflex (MOCR), a sound-evoked reflex that reduces cochlear amplifier gain, may also contribute to forward masking if the preceding sound reduces gain for the signal. Psychophysical evidence of gain reduction can be observed using a growth of masking (GOM) paradigm with an off-frequency forward masker and a precursor. The basilar membrane input/output (I/O) function is estimated from the GOM function, and the I/O function gain is reduced by the precursor. In this study, the effect of precursor duration on this gain reduction effect was examined for on- and off-frequency precursors. With on-frequency precursors, thresholds increased with increasing precursor duration, then decreased (rolled over) for longer durations. Thresholds with off-frequency precursors continued to increase with increasing precursor duration. These results are not consistent with solely neural masking, but may reflect gain reduction that selectively affects on-frequency stimuli. The TWM was modified to include history-dependent gain reduction to simulate the MOCR, called the temporal window model-gain reduction (TWM-GR). The TWM-GR predicted rollover and the differences with on- and off-frequency precursors whereas the TWM did not.

Effect of Round Window Reinforcement on Hearing: A Temporal Bone Study With Clinical Implications for Surgical Reinforcement of the Round Window.

PubMed

Wegner, Inge; Eldaebes, Mostafa M A S; Landry, Thomas G; Adamson, Robert B; Grolman, Wilko; Bance, Manohar L

2016-06-01

Round window reinforcement leads to conductive hearing loss. The round window is stiffened surgically as therapy for various conditions, including perilymphatic fistula and superior semicircular canal dehiscence. Round window reinforcement reduces symptoms in these patients. However, it also reduces fluid displacement in the cochlea and might therefore increase conductive hearing loss. Perichondrium was applied to the round window membrane in nine fresh-frozen, nonpathologic temporal bones. In four temporal bones cartilage was applied subsequently. Acoustic stimuli in the form of frequency sweeps from 250 to 8000 Hz were generated at 110 dB sound pressure level. A total of 16 frequencies in a 1/3-octave series were used. Stapes velocities in response to the acoustic stimuli were measured at equally spaced multiple points covering the stapes footplate using a scanning laser Doppler interferometry system. Measurements were made at baseline, after applying perichondrium, and after applying cartilage. At frequencies up to 1000 Hz perichondrium reinforcement decreased stapes velocities by 1.5 to 2.9 dB compared with no reinforcement (p value = 0.003). Reinforcement with cartilage led to a further deterioration of stapes velocities by 2.6 to 4.2 dB at frequencies up to 1000 Hz (p value = 0.050). The higher frequencies were not affected by perichondrium reinforcement (p value = 0.774) or cartilage reinforcement (p value = 0.644). Our results seem to suggest a modest, clinically negligible effect of reinforcement with perichondrium. Placing cartilage on the round window resulted in a graded effect on stapes velocities in keeping with the increased stiffness of cartilage compared with perichondrium. Even so, the effect was relatively small.

Timing of favorable conditions, competition and fertility interact to govern recruitment of invasive Chinese tallow tree in stressful environments.

PubMed

Gabler, Christopher A; Siemann, Evan

2013-01-01

The rate of new exotic recruitment following removal of adult invaders (reinvasion pressure) influences restoration outcomes and costs but is highly variable and poorly understood. We hypothesize that broad variation in average reinvasion pressure of Triadica sebifera (Chinese tallow tree, a major invader) arises from differences among habitats in spatiotemporal availability of realized recruitment windows. These windows are periods of variable duration long enough to permit establishment given local environmental conditions. We tested this hypothesis via a greenhouse mesocosm experiment that quantified how the duration of favorable moisture conditions prior to flood or drought stress (window duration), competition and nutrient availability influenced Triadica success in high stress environments. Window duration influenced pre-stress seedling abundance and size, growth during stress and final abundance; it interacted with other factors to affect final biomass and germination during stress. Stress type and competition impacted final size and biomass, plus germination, mortality and changes in size during stress. Final abundance also depended on competition and the interaction of window duration, stress type and competition. Fertilization interacted with competition and stress to influence biomass and changes in height, respectively, but did not affect Triadica abundance. Overall, longer window durations promoted Triadica establishment, competition and drought (relative to flood) suppressed establishment, and fertilization had weak effects. Interactions among factors frequently produced different effects in specific contexts. Results support our 'outgrow the stress' hypothesis and show that temporal availability of abiotic windows and factors that influence growth rates govern Triadica recruitment in stressful environments. These findings suggest that native seed addition can effectively suppress superior competitors in stressful environments. We also describe environmental scenarios where specific management methods may be more or less effective. Our results enable better niche-based estimates of local reinvasion pressure, which can improve restoration efficacy and efficiency by informing site selection and optimal management.

Timing of Favorable Conditions, Competition and Fertility Interact to Govern Recruitment of Invasive Chinese Tallow Tree in Stressful Environments

PubMed Central

Gabler, Christopher A.; Siemann, Evan

2013-01-01

The rate of new exotic recruitment following removal of adult invaders (reinvasion pressure) influences restoration outcomes and costs but is highly variable and poorly understood. We hypothesize that broad variation in average reinvasion pressure of Triadica sebifera (Chinese tallow tree, a major invader) arises from differences among habitats in spatiotemporal availability of realized recruitment windows. These windows are periods of variable duration long enough to permit establishment given local environmental conditions. We tested this hypothesis via a greenhouse mesocosm experiment that quantified how the duration of favorable moisture conditions prior to flood or drought stress (window duration), competition and nutrient availability influenced Triadica success in high stress environments. Window duration influenced pre-stress seedling abundance and size, growth during stress and final abundance; it interacted with other factors to affect final biomass and germination during stress. Stress type and competition impacted final size and biomass, plus germination, mortality and changes in size during stress. Final abundance also depended on competition and the interaction of window duration, stress type and competition. Fertilization interacted with competition and stress to influence biomass and changes in height, respectively, but did not affect Triadica abundance. Overall, longer window durations promoted Triadica establishment, competition and drought (relative to flood) suppressed establishment, and fertilization had weak effects. Interactions among factors frequently produced different effects in specific contexts. Results support our ‘outgrow the stress’ hypothesis and show that temporal availability of abiotic windows and factors that influence growth rates govern Triadica recruitment in stressful environments. These findings suggest that native seed addition can effectively suppress superior competitors in stressful environments. We also describe environmental scenarios where specific management methods may be more or less effective. Our results enable better niche-based estimates of local reinvasion pressure, which can improve restoration efficacy and efficiency by informing site selection and optimal management. PMID:23967212

Mesothelial cell proliferation in the scala tympani: a reaction to the rupture of the round window membrane.

PubMed

Sone, M

1998-10-01

The inner layer of the round window membrane is composed of mesothelial cells and this mesothelial cell layer extends to the scala tympani. This study describes the histopathologic findings of temporal bone analysis from a patient with bilateral perilymphatic fistula of the round window membrane. The left ear showed proliferation of mesothelial cells in the scala tympani of the basal turn adjoining the round window membrane. This cell proliferation is thought to be a reaction to the rupture of the round window membrane.

The monaural temporal window based on masking period pattern data in school-aged children and adults.

PubMed

Buss, Emily; He, Shuman; Grose, John H; Hall, Joseph W

2013-03-01

Several lines of evidence indicate that auditory temporal resolution improves over childhood, whereas other data implicate the development of processing efficiency. The present study used the masking period pattern paradigm to examine the maturation of temporal processing in normal-hearing children (4.8 to 10.7 yrs) compared to adults. Thresholds for a brief tone were measured at 6 temporal positions relative to the period of a 5-Hz quasi-square-wave masker envelope, with a 20-dB modulation depth, as well as in 2 steady maskers. The signal was a pure tone at either 1000 or 6500 Hz, and the masker was a band of noise, either spectrally wide or narrow (21.3 and 1.4 equivalent rectangular bandwidths, respectively). Masker modulation improved thresholds more for wide than narrow bandwidths, and adults tended to receive more benefit from modulation than young children. Fits to data for the wide maskers indicated a change in window symmetry with development, reflecting relatively greater backward masking for the youngest listeners. Data for children >6.5 yrs of age appeared more adult-like for the 6500- than the 1000-Hz signal. Differences in temporal window asymmetry with listener age cannot be entirely explained as a consequence of a higher criterion for detection in children, a form of inefficiency.

Temporal Vulnerability and the Post-Disaster 'Window of Opportunity to Woo:' a Case Study of an African-American Floodplain Neighborhood after Hurricane Floyd in North Carolina.

PubMed

de Vries, Daniel H

2017-01-01

After major flooding associated with Hurricane Floyd (1999) in North Carolina, mitigation managers seized upon the "window of opportunity" to woo residents to accept residential buyout offers despite sizable community resistance. I present a theoretical explanation of how post-crisis periods turn into "opportunities" based on a temporal referential theory that complements alternative explanations based on temporal coincidence, panarchy, and shock-doctrine theories. Results from fieldwork conducted from 2002 to 2004 illustrate how several temporal influences compromised collective calibration of "normalcy" in local cultural models, leading to an especially heightened vulnerability to collective surprise. Four factors particularly influenced this temporal vulnerability: 1) epistemological uncertainty of floodplain dynamics due to colonization; 2) cultural practices that maintained a casual amnesia; 3) meaning attributed to stochastic timing of floods; and 4) competitive impact of referential flood baseline attractors.

Performance of the round window soft coupler for the backward stimulation of the cochlea in a temporal bone model.

PubMed

Gostian, Antoniu-Oreste; Schwarz, David; Mandt, Philipp; Anagiotos, Andreas; Ortmann, Magdalene; Pazen, David; Beutner, Dirk; Hüttenbrink, Karl-Bernd

2016-11-01

The round window vibroplasty is a feasible option for the treatment of conductive, sensorineural and mixed hearing loss. Although clinical data suggest a satisfying clinical outcome with various coupling methods, the most efficient coupling technique of the floating mass transducer to the round window is still a matter of debate. For this, a soft silicone-made coupler has been developed recently that aims to ease and optimize the stimulation of the round window membrane of this middle ear implant. We performed a temporal bone study evaluating the performance of the soft coupler compared to the coupling with individually shaped cartilage, perichondrium and the titanium round window coupler with loads up to 20 mN at the unaltered and fully exposed round window niche. The stimulation of the cochlea was measured by the volume velocities of the stapes footplate detected by a laser Doppler vibrometer. The coupling method was computed as significant factor with cartilage and perichondrium allowing for the highest volume velocities followed by the soft and titanium coupler. Exposure of the round window niche allowed for higher volume velocities while the applied load did not significantly affect the results. The soft coupler allows for a good contact to the round window membrane and an effective backward stimulation of the cochlea. Clinical data are mandatory to evaluate performance of this novel coupling method in vivo.

Predictors of round window accessibility for adult cochlear implantation based on pre-operative CT scan: a prospective observational study.

PubMed

Park, Edward; Amoodi, Hosam; Kuthubutheen, Jafri; Chen, Joseph M; Nedzelski, Julian M; Lin, Vincent Y W

2015-05-28

Cochlear implantation has become a mainstream treatment option for patients with severe to profound sensorineural hearing loss. During cochlear implant, there are key surgical steps which are influenced by anatomical variations between each patient. The aim of this study is to determine if there are potential predictors of difficulties that may be encountered during the cortical mastoidectomy, facial recess approach and round window access in cochlear implant surgery based upon pre-operative temporal bone CT scan. Fifty seven patients undergoing unilateral cochlear implantation were analyzed. Difficulty with 1) cortical mastoidectomy, 2) facial recess approach, and 3) round window access were scored intra-operatively by the surgeon in a blinded fashion (1 = "easy", 2 = "moderate", 3 = "difficult"). Pre-operative temporal bone CT scans were analyzed for 1) degree of mastoid aeration; 2) location of the sigmoid sinus; 3) height of the tegmen; 4) the presence of air cells in the facial recess, and 5) degree of round window bony overhang. Poor mastoid aeration and lower tegmen position, but not the location of sigmoid sinus, are associated with greater difficulty with the cortical mastoidectomy. Presence of an air cell around the facial nerve was predictive of easier facial recess access. However, the degree of round window bony overhang was not predictive of difficulty associated with round window access. Certain parameters on the pre-operative temporal bone CT scan may be useful in predicting potential difficulties encountered during the key steps involved in cochlear implant surgery.

Exploring the structure and function of temporal networks with dynamic graphlets

PubMed Central

Hulovatyy, Y.; Chen, H.; Milenković, T.

2015-01-01

Motivation: With increasing availability of temporal real-world networks, how to efficiently study these data? One can model a temporal network as a single aggregate static network, or as a series of time-specific snapshots, each being an aggregate static network over the corresponding time window. Then, one can use established methods for static analysis on the resulting aggregate network(s), but losing in the process valuable temporal information either completely, or at the interface between different snapshots, respectively. Here, we develop a novel approach for studying a temporal network more explicitly, by capturing inter-snapshot relationships. Results: We base our methodology on well-established graphlets (subgraphs), which have been proven in numerous contexts in static network research. We develop new theory to allow for graphlet-based analyses of temporal networks. Our new notion of dynamic graphlets is different from existing dynamic network approaches that are based on temporal motifs (statistically significant subgraphs). The latter have limitations: their results depend on the choice of a null network model that is required to evaluate the significance of a subgraph, and choosing a good null model is non-trivial. Our dynamic graphlets overcome the limitations of the temporal motifs. Also, when we aim to characterize the structure and function of an entire temporal network or of individual nodes, our dynamic graphlets outperform the static graphlets. Clearly, accounting for temporal information helps. We apply dynamic graphlets to temporal age-specific molecular network data to deepen our limited knowledge about human aging. Availability and implementation: http://www.nd.edu/∼cone/DG. Contact: tmilenko@nd.edu Supplementary information: Supplementary data are available at Bioinformatics online. PMID:26072480

Temporal behavior of unresolved transition array emission in water window soft x-ray spectral region from multiply charged ions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dinh, Thanh-Hung, E-mail: dinh@cc.utsunomiya-u.ac.jp; Suzuki, Yuhei; Arai, Goki

2015-09-21

We have characterized the spectral structure and the temporal history of the laser-produced high-Z multi-charged ion plasmas for the efficient water window soft x-ray sources. Strong unresolved transition array emission was observed due to 4d–4f and 4f–5g transitions from Au, Pb, and Bi plasmas in the 280–700 eV photon energy region. The temporal behavior of the emission was essentially similar of that of the laser pulse with a slight delay between different transitions. These results provide feedback for accurate modeling of the atomic processes with the radiative hydrodynamic simulations.

Quality assessment of static aggregation compared to the temporal approach based on a pig trade network in Northern Germany.

PubMed

Büttner, Kathrin; Salau, Jennifer; Krieter, Joachim

2016-07-01

Recent analyses of animal movement networks focused on the static aggregation of trade contacts over different time windows, which neglects the system's temporal variation. In terms of disease spread, ignoring the temporal dynamics can lead to an over- or underestimation of an outbreak's speed and extent. This becomes particularly evident, if the static aggregation allows for the existence of more paths compared to the number of time-respecting paths (i.e. paths in the right chronological order). Therefore, the aim of this study was to reveal differences between static and temporal representations of an animal trade network and to assess the quality of the static aggregation in comparison to the temporal counterpart. Contact data from a pig trade network (2006-2009) of a producer community in Northern Germany were analysed. The results show that a median value of 8.7 % (4.6-14.1%) of the nodes and 3.1% (1.6-5.5%) of the edges were active on a weekly resolution. No fluctuations in the activity patterns were obvious. Furthermore, 50% of the nodes already had one trade contact after approximately six months. For an accumulation window with increasing size (one day each), the accumulation rate, i.e. the relative increase in the number of nodes or edges, stayed relatively constant below 0.07% for the nodes and 0.12 % for the edges. The temporal distances had a much wider distribution than the topological distances. 84% of the temporal distances were smaller than 90 days. The maximum temporal distance was 1000 days, which corresponds to the temporal diameter of the present network. The median temporal correlation coefficient, which measures the probability for an edge to persist across two consecutive time steps, was 0.47, with a maximum value of 0.63 at the accumulation window of 88 days. The causal fidelity measures the fraction of the number of static paths which can also be taken in the temporal network. For the whole observation period relatively high values indicate that 67% of the time-respecting paths existed in both network representations. An increase to 0.87 (0.82-0.88) and 0.92 (0.80-0.98), respectively, could be observed for yearly and monthly aggregation windows. The results show that the investigated pig trade network in its static aggregation represents the temporal dynamics of the system sufficiently well. Therefore, the methodology for analysing static instead of dynamic networks can be used without losing too much information. Copyright © 2016 Elsevier B.V. All rights reserved.

Gap junctions are essential for murine primordial follicle assembly immediately before birth.

PubMed

Teng, Zhen; Wang, Chao; Wang, Yijing; Huang, Kun; Xiang, Xi; Niu, Wanbao; Feng, Lizhao; Zhao, Lihua; Yan, Hao; Zhang, Hua

2016-02-01

The reserve of primordial follicles determines the reproductive ability of the female mammal over its reproductive life. The primordial follicle is composed of two types of cells: oocytes and surrounding pre-granulosa cells. However, the underlying mechanism regulating primordial follicle assembly is largely undefined. In this study, we found that gap junction communication (GJC) established between the ovarian cells in the perinatal mouse ovary may be involved in the process. First, gap junction structures between the oocyte and surrounding pre-granulosa cells appear at about 19.0 dpc (days post coitum). As many as 12 gap junction-related genes are upregulated at birth, implying that a complex communication may exist between ovarian cells, because specifically silencing the genes of individual gap junction proteins, such as Gja1, Gja4 or both, has no influence on primordial follicle assembly. On the other hand, non-specific blockers of GJC, such as carbenoxolone (CBX) and 18α-glycyrrhetinic acid (AGA), significantly inhibit mouse primordial follicle assembly. We proved that the temporal window for establishment of GJC in the fetal ovary is from 19.5 dpc to 1 dpp (days postpartum). In addition, the expression of ovarian somatic cell (OSC)-specific genes, such as Notch2, Foxl2 and Irx3, was negatively affected by GJC blockers, whereas oocyte-related genes, such as Ybx2, Nobox and Sohlh1, were hardly affected, implying that the establishment of GJC during this period may be more important to OSCs than to oocytes. In summary, our results indicated that GJC involves in the mouse primordial follicle assembly process at a specific temporal window that needs Notch signaling cross-talking. © 2016 Society for Reproduction and Fertility.

Time course of brain activation elicited by basic emotions.

PubMed

Hot, Pascal; Sequeira, Henrique

2013-11-13

Whereas facial emotion recognition protocols have shown that each discrete emotion has a specific time course of brain activation, there is no electrophysiological evidence to support these findings for emotional induction by complex pictures. Our objective was to specify the differences between the time courses of brain activation elicited by feelings of happiness and, with unpleasant pictures, by feelings of disgust and sadness. We compared event-related potentials (ERPs) elicited by the watching of high-arousing pictures from the International Affective Picture System, selected to induce specific emotions. In addition to a classical arousal effect on late positive components, we found specific ERP patterns for each emotion in early temporal windows (<200 ms). Disgust was the first emotion to be associated with different brain processing after 140 ms, whereas happiness and sadness differed in ERPs elicited at the frontal and central sites after 160 ms. Our findings highlight the limits of the classical averaging of ERPs elicited by different emotions inside the same valence and suggest that each emotion could elicit a specific temporal pattern of brain activation, similar to those observed with emotional face recognition.

Automatic Multi-sensor Data Quality Checking and Event Detection for Environmental Sensing

NASA Astrophysics Data System (ADS)

LIU, Q.; Zhang, Y.; Zhao, Y.; Gao, D.; Gallaher, D. W.; Lv, Q.; Shang, L.

2017-12-01

With the advances in sensing technologies, large-scale environmental sensing infrastructures are pervasively deployed to continuously collect data for various research and application fields, such as air quality study and weather condition monitoring. In such infrastructures, many sensor nodes are distributed in a specific area and each individual sensor node is capable of measuring several parameters (e.g., humidity, temperature, and pressure), providing massive data for natural event detection and analysis. However, due to the dynamics of the ambient environment, sensor data can be contaminated by errors or noise. Thus, data quality is still a primary concern for scientists before drawing any reliable scientific conclusions. To help researchers identify potential data quality issues and detect meaningful natural events, this work proposes a novel algorithm to automatically identify and rank anomalous time windows from multiple sensor data streams. More specifically, (1) the algorithm adaptively learns the characteristics of normal evolving time series and (2) models the spatial-temporal relationship among multiple sensor nodes to infer the anomaly likelihood of a time series window for a particular parameter in a sensor node. Case studies using different data sets are presented and the experimental results demonstrate that the proposed algorithm can effectively identify anomalous time windows, which may resulted from data quality issues and natural events.

Measurement of Temporal Awareness in Air Traffic Control

NASA Technical Reports Server (NTRS)

Rantanen, E.M.

2009-01-01

Temporal awareness, or level 3 situation awareness, is critical to successful control of air traffic, yet the construct remains ill-defined and difficult to measure. This research sought evidence for air traffic controllers awareness of temporal characteristics of their tasks in data from a high-fidelity system evaluation simulation. Five teams of controllers worked on four scenarios with different traffic load. Several temporal parameters were defined for each task controllers performed during a simulation run and their actions on the tasks were timed relative to them. Controllers showed a strong tendency to prioritize tasks according to a first come, first served principle. This trend persisted as task load increased. Also evident was awareness of the urgency of tasks, as tasks with impending closing of a window of opportunity were performed before tasks that had longer time available before closing of the window.

Auditory Processing Efficiency and Temporal Resolution in Children and Adults.

ERIC Educational Resources Information Center

Hill, Penelope R.; Hartley, Douglas E.H.; Glasberg, Brian R.; Moore, Brian C.J.; Moore, David R.

2004-01-01

Children have higher auditory backward masking (BM) thresholds than adults. One explanation for this is poor temporal resolution, resulting in difficulty separating brief or rapidly presented sounds. This implies that the auditory temporal window is broader in children than in adults. Alternatively, elevated BM thresholds in children may indicate…

Synchronized multiartifact reduction with tomographic reconstruction (SMART-RECON): A statistical model based iterative image reconstruction method to eliminate limited-view artifacts and to mitigate the temporal-average artifacts in time-resolved CT.

PubMed

Chen, Guang-Hong; Li, Yinsheng

2015-08-01

In x-ray computed tomography (CT), a violation of the Tuy data sufficiency condition leads to limited-view artifacts. In some applications, it is desirable to use data corresponding to a narrow temporal window to reconstruct images with reduced temporal-average artifacts. However, the need to reduce temporal-average artifacts in practice may result in a violation of the Tuy condition and thus undesirable limited-view artifacts. In this paper, the authors present a new iterative reconstruction method, synchronized multiartifact reduction with tomographic reconstruction (SMART-RECON), to eliminate limited-view artifacts using data acquired within an ultranarrow temporal window that severely violates the Tuy condition. In time-resolved contrast enhanced CT acquisitions, image contrast dynamically changes during data acquisition. Each image reconstructed from data acquired in a given temporal window represents one time frame and can be denoted as an image vector. Conventionally, each individual time frame is reconstructed independently. In this paper, all image frames are grouped into a spatial-temporal image matrix and are reconstructed together. Rather than the spatial and/or temporal smoothing regularizers commonly used in iterative image reconstruction, the nuclear norm of the spatial-temporal image matrix is used in SMART-RECON to regularize the reconstruction of all image time frames. This regularizer exploits the low-dimensional structure of the spatial-temporal image matrix to mitigate limited-view artifacts when an ultranarrow temporal window is desired in some applications to reduce temporal-average artifacts. Both numerical simulations in two dimensional image slices with known ground truth and in vivo human subject data acquired in a contrast enhanced cone beam CT exam have been used to validate the proposed SMART-RECON algorithm and to demonstrate the initial performance of the algorithm. Reconstruction errors and temporal fidelity of the reconstructed images were quantified using the relative root mean square error (rRMSE) and the universal quality index (UQI) in numerical simulations. The performance of the SMART-RECON algorithm was compared with that of the prior image constrained compressed sensing (PICCS) reconstruction quantitatively in simulations and qualitatively in human subject exam. In numerical simulations, the 240(∘) short scan angular span was divided into four consecutive 60(∘) angular subsectors. SMART-RECON enables four high temporal fidelity images without limited-view artifacts. The average rRMSE is 16% and UQIs are 0.96 and 0.95 for the two local regions of interest, respectively. In contrast, the corresponding average rRMSE and UQIs are 25%, 0.78, and 0.81, respectively, for the PICCS reconstruction. Note that only one filtered backprojection image can be reconstructed from the same data set with an average rRMSE and UQIs are 45%, 0.71, and 0.79, respectively, to benchmark reconstruction accuracies. For in vivo contrast enhanced cone beam CT data acquired from a short scan angular span of 200(∘), three 66(∘) angular subsectors were used in SMART-RECON. The results demonstrated clear contrast difference in three SMART-RECON reconstructed image volumes without limited-view artifacts. In contrast, for the same angular sectors, PICCS cannot reconstruct images without limited-view artifacts and with clear contrast difference in three reconstructed image volumes. In time-resolved CT, the proposed SMART-RECON method provides a new method to eliminate limited-view artifacts using data acquired in an ultranarrow temporal window, which corresponds to approximately 60(∘) angular subsectors.

Electrophysiological Correlates of Individual Differences in Perception of Audiovisual Temporal Asynchrony

PubMed Central

Kaganovich, Natalya; Schumaker, Jennifer

2016-01-01

Sensitivity to the temporal relationship between auditory and visual stimuli is key to efficient audiovisual integration. However, even adults vary greatly in their ability to detect audiovisual temporal asynchrony. What underlies this variability is currently unknown. We recorded event-related potentials (ERPs) while participants performed a simultaneity judgment task on a range of audiovisual (AV) and visual-auditory (VA) stimulus onset asynchronies (SOAs) and compared ERP responses in good and poor performers to the 200 ms SOA, which showed the largest individual variability in the number of synchronous perceptions. Analysis of ERPs to the VA200 stimulus yielded no significant results. However, those individuals who were more sensitive to the AV200 SOA had significantly more positive voltage between 210 and 270 ms following the sound onset. In a follow-up analysis, we showed that the mean voltage within this window predicted approximately 36% of variability in sensitivity to AV temporal asynchrony in a larger group of participants. The relationship between the ERP measure in the 210-270 ms window and accuracy on the simultaneity judgment task also held for two other AV SOAs with significant individual variability - 100 and 300 ms. Because the identified window was time-locked to the onset of sound in the AV stimulus, we conclude that sensitivity to AV temporal asynchrony is shaped to a large extent by the efficiency in the neural encoding of sound onsets. PMID:27094850

Fluid volume displacement at the oval and round windows with air and bone conduction stimulation.

PubMed

Stenfelt, Stefan; Hato, Naohito; Goode, Richard L

2004-02-01

The fluids in the cochlea are normally considered incompressible, and the fluid volume displacement of the oval window (OW) and the round window (RW) should be equal and of opposite phase. However, other channels, such as the cochlear and vestibular aqueducts, may affect the fluid flow. To test if the OW and RW fluid flows are equal and of opposite phase, the volume displacement was assessed by multiple point measurement at the windows with a laser Doppler vibrometer. This was done during air conduction (AC) stimulation in seven fresh human temporal bones, and with bone conduction (BC) stimulation in eight temporal bones and one human cadaver head. With AC stimulation, the average volume displacement of the two windows is within 3 dB, and the phase difference is close to 180 degrees for the frequency range 0.1 to 10 kHz. With BC stimulation, the average volume displacement difference between the two windows is greater: below 2 kHz, the volume displacement at the RW is 5 to 15 dB greater than at the OW and above 2 kHz more fluid is displaced at the OW. With BC stimulation, lesions at the OW caused only minor changes of the fluid flow at the RW.

Fluid volume displacement at the oval and round windows with air and bone conduction stimulation

NASA Astrophysics Data System (ADS)

Stenfelt, Stefan; Hato, Naohito; Goode, Richard L.

2004-02-01

The fluids in the cochlea are normally considered incompressible, and the fluid volume displacement of the oval window (OW) and the round window (RW) should be equal and of opposite phase. However, other channels, such as the cochlear and vestibular aqueducts, may affect the fluid flow. To test if the OW and RW fluid flows are equal and of opposite phase, the volume displacement was assessed by multiple point measurement at the windows with a laser Doppler vibrometer. This was done during air conduction (AC) stimulation in seven fresh human temporal bones, and with bone conduction (BC) stimulation in eight temporal bones and one human cadaver head. With AC stimulation, the average volume displacement of the two windows is within 3 dB, and the phase difference is close to 180° for the frequency range 0.1 to 10 kHz. With BC stimulation, the average volume displacement difference between the two windows is greater: below 2 kHz, the volume displacement at the RW is 5 to 15 dB greater than at the OW and above 2 kHz more fluid is displaced at the OW. With BC stimulation, lesions at the OW caused only minor changes of the fluid flow at the RW.

Temporal dynamics of figure-ground segregation in human vision.

PubMed

Neri, Peter; Levi, Dennis M

2007-01-01

The segregation of figure from ground is arguably one of the most fundamental operations in human vision. Neural signals reflecting this operation appear in cortex as early as 50 ms and as late as 300 ms after presentation of a visual stimulus, but it is not known when these signals are used by the brain to construct the percepts of figure and ground. We used psychophysical reverse correlation to identify the temporal window for figure-ground signals in human perception and found it to lie within the range of 100-160 ms. Figure enhancement within this narrow temporal window was transient rather than sustained as may be expected from measurements in single neurons. These psychophysical results prompt and guide further electrophysiological studies.

The twilight zone: ambient light levels trigger activity in primitive ants.

PubMed

Narendra, Ajay; Reid, Samuel F; Hemmi, Jan M

2010-05-22

Many animals become active during twilight, a narrow time window where the properties of the visual environment are dramatically different from both day and night. Despite the fact that many animals including mammals, reptiles, birds and insects become active in this specific temporal niche, we do not know what cues trigger this activity. To identify the onset of specific temporal niches, animals could anticipate the timing of regular events or directly measure environmental variables. We show that the Australian bull ant, Myrmecia pyriformis, starts foraging only during evening twilight throughout the year. The onset occurs neither at a specific temperature nor at a specific time relative to sunset, but at a specific ambient light intensity. Foraging onset occurs later when light intensities at sunset are brighter than normal or earlier when light intensities at sunset are darker than normal. By modifying ambient light intensity experimentally, we provide clear evidence that ants indeed measure light levels and do not rely on an internal rhythm to begin foraging. We suggest that the reason for restricting the foraging onset to twilight and measuring light intensity to trigger activity is to optimize the trade-off between predation risk and ease of navigation.

The twilight zone: ambient light levels trigger activity in primitive ants

PubMed Central

Narendra, Ajay; Reid, Samuel F.; Hemmi, Jan M.

2010-01-01

Many animals become active during twilight, a narrow time window where the properties of the visual environment are dramatically different from both day and night. Despite the fact that many animals including mammals, reptiles, birds and insects become active in this specific temporal niche, we do not know what cues trigger this activity. To identify the onset of specific temporal niches, animals could anticipate the timing of regular events or directly measure environmental variables. We show that the Australian bull ant, Myrmecia pyriformis, starts foraging only during evening twilight throughout the year. The onset occurs neither at a specific temperature nor at a specific time relative to sunset, but at a specific ambient light intensity. Foraging onset occurs later when light intensities at sunset are brighter than normal or earlier when light intensities at sunset are darker than normal. By modifying ambient light intensity experimentally, we provide clear evidence that ants indeed measure light levels and do not rely on an internal rhythm to begin foraging. We suggest that the reason for restricting the foraging onset to twilight and measuring light intensity to trigger activity is to optimize the trade-off between predation risk and ease of navigation. PMID:20129978

Prenatal Particulate Air Pollution and Neurodevelopment in Urban Children: Examining Sensitive Windows and Sex-specific Associations

PubMed Central

Chiu, Yueh-Hsiu Mathilda; Hsu, Hsiao-Hsien Leon; Coull, Brent A.; Bellinger, David C.; Kloog, Itai; Schwartz, Joel; Wright, Robert O.; Wright, Rosalind J.

2015-01-01

Background Brain growth and structural organization occurs in stages beginning prenatally. Toxicants may impact neurodevelopment differently dependent upon exposure timing and fetal sex. Objectives We implemented innovative methodology to identify sensitive windows for the associations between prenatal particulate matter with diameter≤2.5μm (PM2.5) and children’s neurodevelopment. Methods We assessed 267 full-term urban children’s prenatal daily PM2.5 exposure using a validated satellite-based spatio-temporally resolved prediction model. Outcomes included IQ (WISC-IV), attention (omission errors [OEs], commission errors [CEs], hit reaction time [HRT], and HRT standard error [HRT-SE] on the Conners’ CPT-II), and memory (general memory [GM] index and its components - verbal [VEM] and visual [VIM] memory, and attention-concentration [AC] indices on the WRAML-2) assessed at age 6.5±0.98 years. To identify the role of exposure timing, we used distributed lag models to examine associations between weekly prenatal PM2.5 exposure and neurodevelopment. Sex-specific associations were also examined. Results Mothers were primarily minorities (60% Hispanic, 25% black); 69% had ≤12 years of education. Adjusting for maternal age, education, race, and smoking, we found associations between higher PM2.5 levels at 31–38 weeks with lower IQ, at 20–26 weeks gestation with increased OEs, at 32–36 weeks with slower HRT, and at 22–40 weeks with increased HRT-SE among boys, while significant associations were found in memory domains in girls (higher PM2.5 exposure at 18–26 weeks with reduced VIM, at 12–20 weeks with reduced GM). Conclusions Increased PM2.5 exposure in specific prenatal windows was associated with poorer function across memory and attention domains with variable associations based on sex. Refined determination of time window- and sex-specific associations may enhance insight into underlying mechanisms and identification of vulnerable subgroups. PMID:26641520

Prenatal particulate air pollution and neurodevelopment in urban children: Examining sensitive windows and sex-specific associations.

PubMed

Chiu, Yueh-Hsiu Mathilda; Hsu, Hsiao-Hsien Leon; Coull, Brent A; Bellinger, David C; Kloog, Itai; Schwartz, Joel; Wright, Robert O; Wright, Rosalind J

2016-02-01

Brain growth and structural organization occurs in stages beginning prenatally. Toxicants may impact neurodevelopment differently dependent upon exposure timing and fetal sex. We implemented innovative methodology to identify sensitive windows for the associations between prenatal particulate matter with diameter ≤ 2.5 μm (PM2.5) and children's neurodevelopment. We assessed 267 full-term urban children's prenatal daily PM2.5 exposure using a validated satellite-based spatio-temporally resolved prediction model. Outcomes included IQ (WISC-IV), attention (omission errors [OEs], commission errors [CEs], hit reaction time [HRT], and HRT standard error [HRT-SE] on the Conners' CPT-II), and memory (general memory [GM] index and its components - verbal [VEM] and visual [VIM] memory, and attention-concentration [AC] indices on the WRAML-2) assessed at age 6.5±0.98 years. To identify the role of exposure timing, we used distributed lag models to examine associations between weekly prenatal PM2.5 exposure and neurodevelopment. Sex-specific associations were also examined. Mothers were primarily minorities (60% Hispanic, 25% black); 69% had ≤12 years of education. Adjusting for maternal age, education, race, and smoking, we found associations between higher PM2.5 levels at 31-38 weeks with lower IQ, at 20-26 weeks gestation with increased OEs, at 32-36 weeks with slower HRT, and at 22-40 weeks with increased HRT-SE among boys, while significant associations were found in memory domains in girls (higher PM2.5 exposure at 18-26 weeks with reduced VIM, at 12-20 weeks with reduced GM). Increased PM2.5 exposure in specific prenatal windows may be associated with poorer function across memory and attention domains with variable associations based on sex. Refined determination of time window- and sex-specific associations may enhance insight into underlying mechanisms and identification of vulnerable subgroups. Copyright © 2015 Elsevier Ltd. All rights reserved.

Analytical Computation of the Epidemic Threshold on Temporal Networks

NASA Astrophysics Data System (ADS)

Valdano, Eugenio; Ferreri, Luca; Poletto, Chiara; Colizza, Vittoria

2015-04-01

The time variation of contacts in a networked system may fundamentally alter the properties of spreading processes and affect the condition for large-scale propagation, as encoded in the epidemic threshold. Despite the great interest in the problem for the physics, applied mathematics, computer science, and epidemiology communities, a full theoretical understanding is still missing and currently limited to the cases where the time-scale separation holds between spreading and network dynamics or to specific temporal network models. We consider a Markov chain description of the susceptible-infectious-susceptible process on an arbitrary temporal network. By adopting a multilayer perspective, we develop a general analytical derivation of the epidemic threshold in terms of the spectral radius of a matrix that encodes both network structure and disease dynamics. The accuracy of the approach is confirmed on a set of temporal models and empirical networks and against numerical results. In addition, we explore how the threshold changes when varying the overall time of observation of the temporal network, so as to provide insights on the optimal time window for data collection of empirical temporal networked systems. Our framework is of both fundamental and practical interest, as it offers novel understanding of the interplay between temporal networks and spreading dynamics.

Aging and the Mammalian Regulatory Triumvirate

PubMed Central

Rollo, C. David

2010-01-01

A temporal framework linking circadian rhythms and clocks to aging rates identifies a specific window of target of rapamycin (TOR) signaling associated with growth hormone (GH) and insulin-like growth factor (IGF-1) (largely exclusive of insulin) in early sleep. IGF-1 signaling is released by growth hormone secretory peaks and downregulation of IGF-1 binding protein-1 resulting in activation of the mitogen activated protein kinase/extracellular signal response kinase (MAPK/ERK) and phosphoinositide 3-kinase-protein kinase B (PI3K-PKB/Akt) signaling pathways. Phosphorylation of Akt activates TOR which mediates the protein synthesis and growth functions of the GH axis. TOR activity is also associated with downregulated stress resistance, faster aging and reduced lifespan. IGF-1 signaling is terminated by falling GH and upregulation of IGF-1 binding proteins mediated by somatostatin and rising corticosteroids in later sleep. This suppresses PI3K-Akt signaling, thus activating the forkhead transcription factors (FOXOs) and stress-resistance pathways involved in promoting longevity. Thus, sleep appears to encompass both pathways currently identified as most relevant to aging and they toggle successively on the phosphorylation status of Akt. I propose a modified version of Pearl’s rate of living theory emphasizing the hard-wired antagonism of growth (TOR) and stress resistance (FOXO). The sleep association of TOR and FOXO in temporally separated windows and their sequential temporal deployment may change much of the way we think about aging and how to manipulate it. PMID:22396860

Separation of High Order Harmonics with Fluoride Windows

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allison, Tom; van Tilborg, Jeroen; Wright, Travis

2010-08-02

The lower orders produced in high order harmonic generation can be effciently temporally separated into monochromatic pulses by propagation in a Fluoride window while still preserving their femtosecond pulse duration. We present calculations for MgF2, CaF2, and LiF windows for the third, fifth, and seventh harmonics of 800 nm. We demonstrate the use of this simple and inexpensive technique in a femtosecond pump/probe experiment using the fifth harmonic.

Time-marching multi-grid seismic tomography

NASA Astrophysics Data System (ADS)

Tong, P.; Yang, D.; Liu, Q.

2016-12-01

From the classic ray-based traveltime tomography to the state-of-the-art full waveform inversion, because of the nonlinearity of seismic inverse problems, a good starting model is essential for preventing the convergence of the objective function toward local minima. With a focus on building high-accuracy starting models, we propose the so-called time-marching multi-grid seismic tomography method in this study. The new seismic tomography scheme consists of a temporal time-marching approach and a spatial multi-grid strategy. We first divide the recording period of seismic data into a series of time windows. Sequentially, the subsurface properties in each time window are iteratively updated starting from the final model of the previous time window. There are at least two advantages of the time-marching approach: (1) the information included in the seismic data of previous time windows has been explored to build the starting models of later time windows; (2) seismic data of later time windows could provide extra information to refine the subsurface images. Within each time window, we use a multi-grid method to decompose the scale of the inverse problem. Specifically, the unknowns of the inverse problem are sampled on a coarse mesh to capture the macro-scale structure of the subsurface at the beginning. Because of the low dimensionality, it is much easier to reach the global minimum on a coarse mesh. After that, finer meshes are introduced to recover the micro-scale properties. That is to say, the subsurface model is iteratively updated on multi-grid in every time window. We expect that high-accuracy starting models should be generated for the second and later time windows. We will test this time-marching multi-grid method by using our newly developed eikonal-based traveltime tomography software package tomoQuake. Real application results in the 2016 Kumamoto earthquake (Mw 7.0) region in Japan will be demonstrated.

Musicians have enhanced audiovisual multisensory binding: experience-dependent effects in the double-flash illusion.

PubMed

Bidelman, Gavin M

2016-10-01

Musical training is associated with behavioral and neurophysiological enhancements in auditory processing for both musical and nonmusical sounds (e.g., speech). Yet, whether the benefits of musicianship extend beyond enhancements to auditory-specific skills and impact multisensory (e.g., audiovisual) processing has yet to be fully validated. Here, we investigated multisensory integration of auditory and visual information in musicians and nonmusicians using a double-flash illusion, whereby the presentation of multiple auditory stimuli (beeps) concurrent with a single visual object (flash) induces an illusory perception of multiple flashes. We parametrically varied the onset asynchrony between auditory and visual events (leads and lags of ±300 ms) to quantify participants' "temporal window" of integration, i.e., stimuli in which auditory and visual cues were fused into a single percept. Results show that musically trained individuals were both faster and more accurate at processing concurrent audiovisual cues than their nonmusician peers; nonmusicians had a higher susceptibility for responding to audiovisual illusions and perceived double flashes over an extended range of onset asynchronies compared to trained musicians. Moreover, temporal window estimates indicated that musicians' windows (<100 ms) were ~2-3× shorter than nonmusicians' (~200 ms), suggesting more refined multisensory integration and audiovisual binding. Collectively, findings indicate a more refined binding of auditory and visual cues in musically trained individuals. We conclude that experience-dependent plasticity of intensive musical experience extends beyond simple listening skills, improving multimodal processing and the integration of multiple sensory systems in a domain-general manner.

Moments in Time

PubMed Central

Wittmann, Marc

2011-01-01

It has been suggested that perception and action can be understood as evolving in temporal epochs or sequential processing units. Successive events are fused into units forming a unitary experience or “psychological present.” Studies have identified several temporal integration levels on different time scales which are fundamental for our understanding of behavior and subjective experience. In recent literature concerning the philosophy and neuroscience of consciousness these separate temporal processing levels are not always precisely distinguished. Therefore, empirical evidence from psychophysics and neuropsychology on these distinct temporal processing levels is presented and discussed within philosophical conceptualizations of time experience. On an elementary level, one can identify a functional moment, a basic temporal building block of perception in the range of milliseconds that defines simultaneity and succession. Below a certain threshold temporal order is not perceived, individual events are processed as co-temporal. On a second level, an experienced moment, which is based on temporal integration of up to a few seconds, has been reported in many qualitatively different experiments in perception and action. It has been suggested that this segmental processing mechanism creates temporal windows that provide a logistical basis for conscious representation and the experience of nowness. On a third level of integration, continuity of experience is enabled by working memory in the range of multiple seconds allowing the maintenance of cognitive operations and emotional feelings, leading to mental presence, a temporal window of an individual’s experienced presence. PMID:22022310

Probabilistic estimation of residential air exchange rates for ...

EPA Pesticide Factsheets

Residential air exchange rates (AERs) are a key determinant in the infiltration of ambient air pollution indoors. Population-based human exposure models using probabilistic approaches to estimate personal exposure to air pollutants have relied on input distributions from AER measurements. An algorithm for probabilistically estimating AER was developed based on the Lawrence Berkley National Laboratory Infiltration model utilizing housing characteristics and meteorological data with adjustment for window opening behavior. The algorithm was evaluated by comparing modeled and measured AERs in four US cities (Los Angeles, CA; Detroit, MI; Elizabeth, NJ; and Houston, TX) inputting study-specific data. The impact on the modeled AER of using publically available housing data representative of the region for each city was also assessed. Finally, modeled AER based on region-specific inputs was compared with those estimated using literature-based distributions. While modeled AERs were similar in magnitude to the measured AER they were consistently lower for all cities except Houston. AERs estimated using region-specific inputs were lower than those using study-specific inputs due to differences in window opening probabilities. The algorithm produced more spatially and temporally variable AERs compared with literature-based distributions reflecting within- and between-city differences, helping reduce error in estimates of air pollutant exposure. Published in the Journal of

Specification and Verification of Web Applications in Rewriting Logic

NASA Astrophysics Data System (ADS)

Alpuente, María; Ballis, Demis; Romero, Daniel

This paper presents a Rewriting Logic framework that formalizes the interactions between Web servers and Web browsers through a communicating protocol abstracting HTTP. The proposed framework includes a scripting language that is powerful enough to model the dynamics of complex Web applications by encompassing the main features of the most popular Web scripting languages (e.g. PHP, ASP, Java Servlets). We also provide a detailed characterization of browser actions (e.g. forward/backward navigation, page refresh, and new window/tab openings) via rewrite rules, and show how our models can be naturally model-checked by using the Linear Temporal Logic of Rewriting (LTLR), which is a Linear Temporal Logic specifically designed for model-checking rewrite theories. Our formalization is particularly suitable for verification purposes, since it allows one to perform in-depth analyses of many subtle aspects related to Web interaction. Finally, the framework has been completely implemented in Maude, and we report on some successful experiments that we conducted by using the Maude LTLR model-checker.

NASA TLX: software for assessing subjective mental workload.

PubMed

Cao, Alex; Chintamani, Keshav K; Pandya, Abhilash K; Ellis, R Darin

2009-02-01

The NASA Task Load Index (TLX) is a popular technique for measuring subjective mental workload. It relies on a multidimensional construct to derive an overall workload score based on a weighted average of ratings on six subscales: mental demand, physical demand, temporal demand, performance, effort, and frustration level. A program for implementing a computerized version of the NASA TLX is described. The software version assists in simplifying collection, postprocessing, and storage of raw data. The program collects raw data from the subject and calculates the weighted (or unweighted) workload score, which is output to a text file. The program can also be tailored to a specific experiment using a simple input text file, if desired. The program was designed in Visual Studio 2005 and is capable of running on a Pocket PC with Windows CE or on a PC with Windows 2000 or higher. The NASA TLX program is available for free download.

Combining Temporal and Spectral Information with Spatial Mapping to Identify Differences between Phonological and Semantic Networks: A Magnetoencephalographic Approach.

PubMed

McNab, Fiona; Hillebrand, Arjan; Swithenby, Stephen J; Rippon, Gina

2012-01-01

Early, lesion-based models of language processing suggested that semantic and phonological processes are associated with distinct temporal and parietal regions respectively, with frontal areas more indirectly involved. Contemporary spatial brain mapping techniques have not supported such clear-cut segregation, with strong evidence of activation in left temporal areas by both processes and disputed evidence of involvement of frontal areas in both processes. We suggest that combining spatial information with temporal and spectral data may allow a closer scrutiny of the differential involvement of closely overlapping cortical areas in language processing. Using beamforming techniques to analyze magnetoencephalography data, we localized the neuronal substrates underlying primed responses to nouns requiring either phonological or semantic processing, and examined the associated measures of time and frequency in those areas where activation was common to both tasks. Power changes in the beta (14-30 Hz) and gamma (30-50 Hz) frequency bands were analyzed in pre-selected time windows of 350-550 and 500-700 ms In left temporal regions, both tasks elicited power changes in the same time window (350-550 ms), but with different spectral characteristics, low beta (14-20 Hz) for the phonological task and high beta (20-30 Hz) for the semantic task. In frontal areas (BA10), both tasks elicited power changes in the gamma band (30-50 Hz), but in different time windows, 500-700 ms for the phonological task and 350-550 ms for the semantic task. In the left inferior parietal area (BA40), both tasks elicited changes in the 20-30 Hz beta frequency band but in different time windows, 350-550 ms for the phonological task and 500-700 ms for the semantic task. Our findings suggest that, where spatial measures may indicate overlapping areas of involvement, additional beamforming techniques can demonstrate differential activation in time and frequency domains.

Temporal Integration Windows in Neural Processing and Perception Aligned to Saccadic Eye Movements.

PubMed

Wutz, Andreas; Muschter, Evelyn; van Koningsbruggen, Martijn G; Weisz, Nathan; Melcher, David

2016-07-11

When processing dynamic input, the brain balances the opposing needs of temporal integration and sensitivity to change. We hypothesized that the visual system might resolve this challenge by aligning integration windows to the onset of newly arriving sensory samples. In a series of experiments, human participants observed the same sequence of two displays separated by a brief blank delay when performing either an integration or segregation task. First, using magneto-encephalography (MEG), we found a shift in the stimulus-evoked time courses by a 150-ms time window between task signals. After stimulus onset, multivariate pattern analysis (MVPA) decoding of task in occipital-parietal sources remained above chance for almost 1 s, and the task-decoding pattern interacted with task outcome. In the pre-stimulus period, the oscillatory phase in the theta frequency band was informative about both task processing and behavioral outcome for each task separately, suggesting that the post-stimulus effects were caused by a theta-band phase shift. Second, when aligning stimulus presentation to the onset of eye fixations, there was a similar phase shift in behavioral performance according to task demands. In both MEG and behavioral measures, task processing was optimal first for segregation and then integration, with opposite phase in the theta frequency range (3-5 Hz). The best fit to neurophysiological and behavioral data was given by a dampened 3-Hz oscillation from stimulus or eye fixation onset. The alignment of temporal integration windows to input changes found here may serve to actively organize the temporal processing of continuous sensory input. Copyright © 2016 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Quantifying nonergodicity in nonautonomous dissipative dynamical systems: An application to climate change

NASA Astrophysics Data System (ADS)

Drótos, Gábor; Bódai, Tamás; Tél, Tamás

2016-08-01

In nonautonomous dynamical systems, like in climate dynamics, an ensemble of trajectories initiated in the remote past defines a unique probability distribution, the natural measure of a snapshot attractor, for any instant of time, but this distribution typically changes in time. In cases with an aperiodic driving, temporal averages taken along a single trajectory would differ from the corresponding ensemble averages even in the infinite-time limit: ergodicity does not hold. It is worth considering this difference, which we call the nonergodic mismatch, by taking time windows of finite length for temporal averaging. We point out that the probability distribution of the nonergodic mismatch is qualitatively different in ergodic and nonergodic cases: its average is zero and typically nonzero, respectively. A main conclusion is that the difference of the average from zero, which we call the bias, is a useful measure of nonergodicity, for any window length. In contrast, the standard deviation of the nonergodic mismatch, which characterizes the spread between different realizations, exhibits a power-law decrease with increasing window length in both ergodic and nonergodic cases, and this implies that temporal and ensemble averages differ in dynamical systems with finite window lengths. It is the average modulus of the nonergodic mismatch, which we call the ergodicity deficit, that represents the expected deviation from fulfilling the equality of temporal and ensemble averages. As an important finding, we demonstrate that the ergodicity deficit cannot be reduced arbitrarily in nonergodic systems. We illustrate via a conceptual climate model that the nonergodic framework may be useful in Earth system dynamics, within which we propose the measure of nonergodicity, i.e., the bias, as an order-parameter-like quantifier of climate change.

Mining approximate temporal functional dependencies with pure temporal grouping in clinical databases.

PubMed

Combi, Carlo; Mantovani, Matteo; Sabaini, Alberto; Sala, Pietro; Amaddeo, Francesco; Moretti, Ugo; Pozzi, Giuseppe

2015-07-01

Functional dependencies (FDs) typically represent associations over facts stored by a database, such as "patients with the same symptom get the same therapy." In more recent years, some extensions have been introduced to represent both temporal constraints (temporal functional dependencies - TFDs), as "for any given month, patients with the same symptom must have the same therapy, but their therapy may change from one month to the next one," and approximate properties (approximate functional dependencies - AFDs), as "patients with the same symptomgenerallyhave the same therapy." An AFD holds most of the facts stored by the database, enabling some data to deviate from the defined property: the percentage of data which violate the given property is user-defined. According to this scenario, in this paper we introduce approximate temporal functional dependencies (ATFDs) and use them to mine clinical data. Specifically, we considered the need for deriving new knowledge from psychiatric and pharmacovigilance data. ATFDs may be defined and measured either on temporal granules (e.g.grouping data by day, week, month, year) or on sliding windows (e.g.a fixed-length time interval which moves over the time axis): in this regard, we propose and discuss some specific and efficient data mining techniques for ATFDs. We also developed two running prototypes and showed the feasibility of our proposal by mining two real-world clinical data sets. The clinical interest of the dependencies derived considering the psychiatry and pharmacovigilance domains confirms the soundness and the usefulness of the proposed techniques. Copyright © 2014 Elsevier Ltd. All rights reserved.

Calibration of Safecast dose rate measurements.

PubMed

Cervone, Guido; Hultquist, Carolynne

2018-10-01

A methodology is presented to calibrate contributed Safecast dose rate measurements acquired between 2011 and 2016 in the Fukushima prefecture of Japan. The Safecast data are calibrated using observations acquired by the U.S. Department of Energy at the time of the 2011 Fukushima Daiichi power plant nuclear accident. The methodology performs a series of interpolations between the U.S. government and contributed datasets at specific temporal windows and at corresponding spatial locations. The coefficients found for all the different temporal windows are aggregated and interpolated using quadratic regressions to generate a time dependent calibration function. Normal background radiation, decay rates, and missing values are taken into account during the analysis. Results show that the standard Safecast static transformation function overestimates the official measurements because it fails to capture the presence of two different Cesium isotopes and their changing magnitudes with time. A model is created to predict the ratio of the isotopes from the time of the accident through 2020. The proposed time dependent calibration takes into account this Cesium isotopes ratio, and it is shown to reduce the error between U.S. government and contributed data. The proposed calibration is needed through 2020, after which date the errors introduced by ignoring the presence of different isotopes will become negligible. Copyright © 2018 Elsevier Ltd. All rights reserved.

Temporal Patterns of Alcohol Consumption and Alcohol-Related Road Accidents in Young Swiss Men: Seasonal, Weekday and Public Holiday Effects.

PubMed

Foster, Simon; Gmel, Gerhard; Estévez, Natalia; Bähler, Caroline; Mohler-Kuo, Meichun

2015-09-01

To assess seasonal, weekday, and public holiday effects on alcohol-related road accidents and drinking diaries among young Swiss men. Federal road accident data (35,485 accidents) from Switzerland and drinking diary data from a large cohort of young Swiss men (11,930 subjects) were analysed for temporal effects by calendar week, weekday and public holiday (Christmas, New Years, National Day). Alcohol-related accidents were analysed using rate ratios for observed versus expected numbers of accidents and proportions of alcohol-related accidents relative to the total number. Drinking diaries were analysed for the proportion of drinkers, median number of drinks consumed, and the 90th percentile's number of drinks consumed. Several parallel peaks were identified in alcohol-related accidents and drinking diaries. These included increases on Fridays and Saturdays, with Saturday drinking extending until early Sunday morning, an increase during the summer on workdays but not weekends, an increase at the end of the year, and increases on public holidays and the evening before. Our results suggest specific time-windows that are associated with increases in drinking and alcohol-related harm. Established prevention measures should be enforced during these time-windows to reduce associated peaks. © The Author 2015. Medical Council on Alcohol and Oxford University Press. All rights reserved.

DNA methylation as a dynamic regulator of development and disease processes: spotlight on the prostate.

PubMed

Keil, Kimberly P; Vezina, Chad M

2015-01-01

Prostate development, benign hyperplasia and cancer involve androgen and growth factor signaling as well as stromal-epithelial interactions. We review how DNA methylation influences these and related processes in other organ systems such as how proliferation is restricted to specific cell populations during defined temporal windows, how androgens elicit their actions and how cells establish, maintain and remodel DNA methylation in a time and cell specific fashion. We also discuss mechanisms by which hormones and endocrine disrupting chemicals reprogram DNA methylation in the prostate and elsewhere and examine evidence for a reawakening of developmental epigenetic pathways as drivers of prostate cancer and benign prostate hyperplasia.

DNA methylation as a dynamic regulator of development and disease processes: spotlight on the prostate

PubMed Central

Keil, Kimberly P; Vezina, Chad M

2015-01-01

Prostate development, benign hyperplasia and cancer involve androgen and growth factor signaling as well as stromal–epithelial interactions. We review how DNA methylation influences these and related processes in other organ systems such as how proliferation is restricted to specific cell populations during defined temporal windows, how androgens elicit their actions and how cells establish, maintain and remodel DNA methylation in a time and cell specific fashion. We also discuss mechanisms by which hormones and endocrine disrupting chemicals reprogram DNA methylation in the prostate and elsewhere and examine evidence for a reawakening of developmental epigenetic pathways as drivers of prostate cancer and benign prostate hyperplasia. PMID:26077429

Temporal correlation coefficient for directed networks.

PubMed

Büttner, Kathrin; Salau, Jennifer; Krieter, Joachim

2016-01-01

Previous studies dealing with network theory focused mainly on the static aggregation of edges over specific time window lengths. Thus, most of the dynamic information gets lost. To assess the quality of such a static aggregation the temporal correlation coefficient can be calculated. It measures the overall possibility for an edge to persist between two consecutive snapshots. Up to now, this measure is only defined for undirected networks. Therefore, we introduce the adaption of the temporal correlation coefficient to directed networks. This new methodology enables the distinction between ingoing and outgoing edges. Besides a small example network presenting the single calculation steps, we also calculated the proposed measurements for a real pig trade network to emphasize the importance of considering the edge direction. The farm types at the beginning of the pork supply chain showed clearly higher values for the outgoing temporal correlation coefficient compared to the farm types at the end of the pork supply chain. These farm types showed higher values for the ingoing temporal correlation coefficient. The temporal correlation coefficient is a valuable tool to understand the structural dynamics of these systems, as it assesses the consistency of the edge configuration. The adaption of this measure for directed networks may help to preserve meaningful additional information about the investigated network that might get lost if the edge directions are ignored.

Contribution of Temporal Preparation and Processing Speed to Simple Reaction Time in Persons with Alzheimer's Disease and Mild Cognitive Impairment

ERIC Educational Resources Information Center

Sylvain-Roy, Stephanie; Bherer, Louis; Belleville, Sylvie

2010-01-01

Temporal preparation was assessed in 15 Alzheimer's disease (AD) patients, 20 persons with mild cognitive impairment (MCI) and 28 healthy older adults. Participants completed a simple reaction time task in which the preparatory interval duration varied randomly within two blocks (short versus long temporal window). Results indicated that AD and…

Temporal integration at consecutive processing stages in the auditory pathway of the grasshopper.

PubMed

Wirtssohn, Sarah; Ronacher, Bernhard

2015-04-01

Temporal integration in the auditory system of locusts was quantified by presenting single clicks and click pairs while performing intracellular recordings. Auditory neurons were studied at three processing stages, which form a feed-forward network in the metathoracic ganglion. Receptor neurons and most first-order interneurons ("local neurons") encode the signal envelope, while second-order interneurons ("ascending neurons") tend to extract more complex, behaviorally relevant sound features. In different neuron types of the auditory pathway we found three response types: no significant temporal integration (some ascending neurons), leaky energy integration (receptor neurons and some local neurons), and facilitatory processes (some local and ascending neurons). The receptor neurons integrated input over very short time windows (<2 ms). Temporal integration on longer time scales was found at subsequent processing stages, indicative of within-neuron computations and network activity. These different strategies, realized at separate processing stages and in parallel neuronal pathways within one processing stage, could enable the grasshopper's auditory system to evaluate longer time windows and thus to implement temporal filters, while at the same time maintaining a high temporal resolution. Copyright © 2015 the American Physiological Society.

Synchronized multiartifact reduction with tomographic reconstruction (SMART-RECON): A statistical model based iterative image reconstruction method to eliminate limited-view artifacts and to mitigate the temporal-average artifacts in time-resolved CT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Guang-Hong, E-mail: gchen7@wisc.edu; Li, Yinsheng

Purpose: In x-ray computed tomography (CT), a violation of the Tuy data sufficiency condition leads to limited-view artifacts. In some applications, it is desirable to use data corresponding to a narrow temporal window to reconstruct images with reduced temporal-average artifacts. However, the need to reduce temporal-average artifacts in practice may result in a violation of the Tuy condition and thus undesirable limited-view artifacts. In this paper, the authors present a new iterative reconstruction method, synchronized multiartifact reduction with tomographic reconstruction (SMART-RECON), to eliminate limited-view artifacts using data acquired within an ultranarrow temporal window that severely violates the Tuy condition. Methods:more » In time-resolved contrast enhanced CT acquisitions, image contrast dynamically changes during data acquisition. Each image reconstructed from data acquired in a given temporal window represents one time frame and can be denoted as an image vector. Conventionally, each individual time frame is reconstructed independently. In this paper, all image frames are grouped into a spatial–temporal image matrix and are reconstructed together. Rather than the spatial and/or temporal smoothing regularizers commonly used in iterative image reconstruction, the nuclear norm of the spatial–temporal image matrix is used in SMART-RECON to regularize the reconstruction of all image time frames. This regularizer exploits the low-dimensional structure of the spatial–temporal image matrix to mitigate limited-view artifacts when an ultranarrow temporal window is desired in some applications to reduce temporal-average artifacts. Both numerical simulations in two dimensional image slices with known ground truth and in vivo human subject data acquired in a contrast enhanced cone beam CT exam have been used to validate the proposed SMART-RECON algorithm and to demonstrate the initial performance of the algorithm. Reconstruction errors and temporal fidelity of the reconstructed images were quantified using the relative root mean square error (rRMSE) and the universal quality index (UQI) in numerical simulations. The performance of the SMART-RECON algorithm was compared with that of the prior image constrained compressed sensing (PICCS) reconstruction quantitatively in simulations and qualitatively in human subject exam. Results: In numerical simulations, the 240{sup ∘} short scan angular span was divided into four consecutive 60{sup ∘} angular subsectors. SMART-RECON enables four high temporal fidelity images without limited-view artifacts. The average rRMSE is 16% and UQIs are 0.96 and 0.95 for the two local regions of interest, respectively. In contrast, the corresponding average rRMSE and UQIs are 25%, 0.78, and 0.81, respectively, for the PICCS reconstruction. Note that only one filtered backprojection image can be reconstructed from the same data set with an average rRMSE and UQIs are 45%, 0.71, and 0.79, respectively, to benchmark reconstruction accuracies. For in vivo contrast enhanced cone beam CT data acquired from a short scan angular span of 200{sup ∘}, three 66{sup ∘} angular subsectors were used in SMART-RECON. The results demonstrated clear contrast difference in three SMART-RECON reconstructed image volumes without limited-view artifacts. In contrast, for the same angular sectors, PICCS cannot reconstruct images without limited-view artifacts and with clear contrast difference in three reconstructed image volumes. Conclusions: In time-resolved CT, the proposed SMART-RECON method provides a new method to eliminate limited-view artifacts using data acquired in an ultranarrow temporal window, which corresponds to approximately 60{sup ∘} angular subsectors.« less

Single-shot measurement of phase and amplitude by using a heterodyne time-lens system and ultrafast digital time-holography

NASA Astrophysics Data System (ADS)

Tikan, Alexey; Bielawski, Serge; Szwaj, Christophe; Randoux, Stéphane; Suret, Pierre

2018-04-01

Temporal imaging systems are outstanding tools for single-shot observation of optical signals that have irregular and ultrafast dynamics. They allow long time windows to be recorded with femtosecond resolution, and do not rely on complex algorithms. However, simultaneous recording of amplitude and phase remains an open challenge for these systems. Here, we present a new heterodyne time-lens arrangement that efficiently records both the amplitude and phase of complex and random signals over large temporal windows (tens of picoseconds). Phase and time are encoded onto the two spatial dimensions of a camera. We implement this phase-sensitive time-lens system in two configurations: a time microscope and a digital temporal-holography device that enables single-shot measurement with a temporal resolution of 80 fs. We demonstrate direct application of our heterodyne time-lens to turbulent-like optical fields and optical rogue waves generated from nonlinear propagation of partially coherent waves inside optical fibres.

Prenatal particulate air pollution exposure and body composition in urban preschool children: Examining sensitive windows and sex-specific associations.

PubMed

Chiu, Yueh-Hsiu Mathilda; Hsu, Hsiao-Hsien Leon; Wilson, Ander; Coull, Brent A; Pendo, Mathew P; Baccarelli, Andrea; Kloog, Itai; Schwartz, Joel; Wright, Robert O; Taveras, Elsie M; Wright, Rosalind J

2017-10-01

Evolving animal studies and limited epidemiological data show that prenatal air pollution exposure is associated with childhood obesity. Timing of exposure and child sex may play an important role in these associations. We applied an innovative method to examine sex-specific sensitive prenatal windows of exposure to PM 2.5 on anthropometric measures in preschool-aged children. Analyses included 239 children born ≥ 37 weeks gestation in an ethnically-mixed lower-income urban birth cohort. Prenatal daily PM 2.5 exposure was estimated using a validated satellite-based spatio-temporal model. Body mass index z-score (BMI-z), fat mass, % body fat, subscapular and triceps skinfold thickness, waist and hip circumferences and waist-to-hip ratio (WHR) were assessed at age 4.0 ± 0.7 years. Using Bayesian distributed lag interaction models (BDLIMs), we examined sex differences in sensitive windows of weekly averaged PM 2.5 levels on these measures, adjusting for child age, maternal age, education, race/ethnicity, and pre-pregnancy BMI. Mothers were primarily Hispanic (55%) or Black (26%), had ≤ 12 years of education (66%) and never smoked (80%). Increased PM 2.5 exposure 8-17 and 15-22 weeks gestation was significantly associated with increased BMI z-scores and fat mass in boys, but not in girls. Higher PM 2.5 exposure 10-29 weeks gestation was significantly associated with increased WHR in girls, but not in boys. Prenatal PM 2.5 was not significantly associated with other measures of body composition. Estimated cumulative effects across pregnancy, accounting for sensitive windows and within-window effects, were 0.21 (95%CI = 0.01-0.37) for BMI-z and 0.36 (95%CI = 0.12-0.68) for fat mass (kg) in boys, and 0.02 (95%CI = 0.01-0.03) for WHR in girls, all per µg/m 3 increase in PM 2.5 . Increased prenatal PM 2.5 exposure was more strongly associated with indices of increased whole body size in boys and with an indicator of body shape in girls. Methods to better characterize vulnerable windows may provide insight into underlying mechanisms contributing to sex-specific associations. Copyright © 2017 Elsevier Inc. All rights reserved.

Temporal coordination of olfactory cortex sharp-wave activity with up- and downstates in the orbitofrontal cortex during slow-wave sleep.

PubMed

Onisawa, Naomi; Manabe, Hiroyuki; Mori, Kensaku

2017-01-01

During slow-wave sleep, interareal communications via coordinated, slow oscillatory activities occur in the large-scale networks of the mammalian neocortex. Because olfactory cortex (OC) areas, which belong to paleocortex, show characteristic sharp-wave (SPW) activity during slow-wave sleep, we examined whether OC SPWs in freely behaving rats occur in temporal coordination with up- and downstates of the orbitofrontal cortex (OFC) slow oscillation. Simultaneous recordings of local field potentials and spike activities in the OC and OFC showed that during the downstate in the OFC, the OC also exhibited downstate with greatly reduced neuronal activity and suppression of SPW generation. OC SPWs occurred during two distinct phases of the upstate of the OFC: early-phase SPWs occurred at the start of upstate shortly after the down-to-up transition in the OFC, whereas late-phase SPWs were generated at the end of upstate shortly before the up-to-down transition. Such temporal coordination between neocortical up- and downstates and olfactory system SPWs was observed between the prefrontal cortex areas (OFC and medial prefrontal cortex) and the OC areas (anterior piriform cortex and posterior piriform cortex). These results suggest that during slow-wave sleep, OC and OFC areas communicate preferentially in specific time windows shortly after the down-to-up transition and shortly before the up-to-down transition. Simultaneous recordings of local field potentials and spike activities in the anterior piriform cortex (APC) and orbitofrontal cortex (OFC) during slow-wave sleep showed that APC sharp waves tended to occur during two distinct phases of OFC upstate: early phase, shortly after the down-to-up transition, and late phase, shortly before the up-to-down transition, suggesting that during slow-wave sleep, olfactory cortex and OFC areas communicate preferentially in the specific time windows. Copyright © 2017 the American Physiological Society.

Temporal coordination of olfactory cortex sharp-wave activity with up- and downstates in the orbitofrontal cortex during slow-wave sleep

PubMed Central

Onisawa, Naomi; Mori, Kensaku

2016-01-01

During slow-wave sleep, interareal communications via coordinated, slow oscillatory activities occur in the large-scale networks of the mammalian neocortex. Because olfactory cortex (OC) areas, which belong to paleocortex, show characteristic sharp-wave (SPW) activity during slow-wave sleep, we examined whether OC SPWs in freely behaving rats occur in temporal coordination with up- and downstates of the orbitofrontal cortex (OFC) slow oscillation. Simultaneous recordings of local field potentials and spike activities in the OC and OFC showed that during the downstate in the OFC, the OC also exhibited downstate with greatly reduced neuronal activity and suppression of SPW generation. OC SPWs occurred during two distinct phases of the upstate of the OFC: early-phase SPWs occurred at the start of upstate shortly after the down-to-up transition in the OFC, whereas late-phase SPWs were generated at the end of upstate shortly before the up-to-down transition. Such temporal coordination between neocortical up- and downstates and olfactory system SPWs was observed between the prefrontal cortex areas (OFC and medial prefrontal cortex) and the OC areas (anterior piriform cortex and posterior piriform cortex). These results suggest that during slow-wave sleep, OC and OFC areas communicate preferentially in specific time windows shortly after the down-to-up transition and shortly before the up-to-down transition. NEW & NOTEWORTHY Simultaneous recordings of local field potentials and spike activities in the anterior piriform cortex (APC) and orbitofrontal cortex (OFC) during slow-wave sleep showed that APC sharp waves tended to occur during two distinct phases of OFC upstate: early phase, shortly after the down-to-up transition, and late phase, shortly before the up-to-down transition, suggesting that during slow-wave sleep, olfactory cortex and OFC areas communicate preferentially in the specific time windows. PMID:27733591

Compensation for Blur Requires Increase in Field of View and Viewing Time

PubMed Central

Kwon, MiYoung; Liu, Rong; Chien, Lillian

2016-01-01

Spatial resolution is an important factor for human pattern recognition. In particular, low resolution (blur) is a defining characteristic of low vision. Here, we examined spatial (field of view) and temporal (stimulus duration) requirements for blurry object recognition. The spatial resolution of an image such as letter or face, was manipulated with a low-pass filter. In experiment 1, studying spatial requirement, observers viewed a fixed-size object through a window of varying sizes, which was repositioned until object identification (moving window paradigm). Field of view requirement, quantified as the number of “views” (window repositions) for correct recognition, was obtained for three blur levels, including no blur. In experiment 2, studying temporal requirement, we determined threshold viewing time, the stimulus duration yielding criterion recognition accuracy, at six blur levels, including no blur. For letter and face recognition, we found blur significantly increased the number of views, suggesting a larger field of view is required to recognize blurry objects. We also found blur significantly increased threshold viewing time, suggesting longer temporal integration is necessary to recognize blurry objects. The temporal integration reflects the tradeoff between stimulus intensity and time. While humans excel at recognizing blurry objects, our findings suggest compensating for blur requires increased field of view and viewing time. The need for larger spatial and longer temporal integration for recognizing blurry objects may further challenge object recognition in low vision. Thus, interactions between blur and field of view should be considered for developing low vision rehabilitation or assistive aids. PMID:27622710

A unified approach to the study of temporal, correlational, and rate coding.

PubMed

Panzeri, S; Schultz, S R

2001-06-01

We demonstrate that the information contained in the spike occurrence times of a population of neurons can be broken up into a series of terms, each reflecting something about potential coding mechanisms. This is possible in the coding regime in which few spikes are emitted in the relevant time window. This approach allows us to study the additional information contributed by spike timing beyond that present in the spike counts and to examine the contributions to the whole information of different statistical properties of spike trains, such as firing rates and correlation functions. It thus forms the basis for a new quantitative procedure for analyzing simultaneous multiple neuron recordings and provides theoretical constraints on neural coding strategies. We find a transition between two coding regimes, depending on the size of the relevant observation timescale. For time windows shorter than the timescale of the stimulus-induced response fluctuations, there exists a spike count coding phase, in which the purely temporal information is of third order in time. For time windows much longer than the characteristic timescale, there can be additional timing information of first order, leading to a temporal coding phase in which timing information may affect the instantaneous information rate. In this new framework, we study the relative contributions of the dynamic firing rate and correlation variables to the full temporal information, the interaction of signal and noise correlations in temporal coding, synergy between spikes and between cells, and the effect of refractoriness. We illustrate the utility of the technique by analyzing a few cells from the rat barrel cortex.

On the relationship between instantaneous phase synchrony and correlation-based sliding windows for time-resolved fMRI connectivity analysis.

PubMed

Pedersen, Mangor; Omidvarnia, Amir; Zalesky, Andrew; Jackson, Graeme D

2018-06-08

Correlation-based sliding window analysis (CSWA) is the most commonly used method to estimate time-resolved functional MRI (fMRI) connectivity. However, instantaneous phase synchrony analysis (IPSA) is gaining popularity mainly because it offers single time-point resolution of time-resolved fMRI connectivity. We aim to provide a systematic comparison between these two approaches, on both temporal and topological levels. For this purpose, we used resting-state fMRI data from two separate cohorts with different temporal resolutions (45 healthy subjects from Human Connectome Project fMRI data with repetition time of 0.72 s and 25 healthy subjects from a separate validation fMRI dataset with a repetition time of 3 s). For time-resolved functional connectivity analysis, we calculated tapered CSWA over a wide range of different window lengths that were temporally and topologically compared to IPSA. We found a strong association in connectivity dynamics between IPSA and CSWA when considering the absolute values of CSWA. The association between CSWA and IPSA was stronger for a window length of ∼20 s (shorter than filtered fMRI wavelength) than ∼100 s (longer than filtered fMRI wavelength), irrespective of the sampling rate of the underlying fMRI data. Narrow-band filtering of fMRI data (0.03-0.07 Hz) yielded a stronger relationship between IPSA and CSWA than wider-band (0.01-0.1 Hz). On a topological level, time-averaged IPSA and CSWA nodes were non-linearly correlated for both short (∼20 s) and long (∼100 s) windows, mainly because nodes with strong negative correlations (CSWA) displayed high phase synchrony (IPSA). IPSA and CSWA were anatomically similar in the default mode network, sensory cortex, insula and cerebellum. Our results suggest that IPSA and CSWA provide comparable characterizations of time-resolved fMRI connectivity for appropriately chosen window lengths. Although IPSA requires narrow-band fMRI filtering, we recommend the use of IPSA given that it does not mandate a (semi-)arbitrary choice of window length and window overlap. A code for calculating IPSA is provided. Copyright © 2018. Published by Elsevier Inc.

Audiovisual Asynchrony Detection in Human Speech

ERIC Educational Resources Information Center

Maier, Joost X.; Di Luca, Massimiliano; Noppeney, Uta

2011-01-01

Combining information from the visual and auditory senses can greatly enhance intelligibility of natural speech. Integration of audiovisual speech signals is robust even when temporal offsets are present between the component signals. In the present study, we characterized the temporal integration window for speech and nonspeech stimuli with…

Scala tympani cochleostomy II: topography and histology.

PubMed

Adunka, Oliver F; Radeloff, Andreas; Gstoettner, Wolfgang K; Pillsbury, Harold C; Buchman, Craig A

2007-12-01

To assess intracochlear trauma using two different round window-related cochleostomy techniques in human temporal bones. Twenty-eight human temporal bones were included in this study. In 21 specimens, cochleostomies were initiated inferior to the round window (RW) annulus. In seven bones, cochleostomies were drilled anterior-inferior to the RW annulus. Limited cochlear implant electrode insertions were performed in 19 bones. In each specimen, promontory anatomy and cochleostomy drilling were photographically documented. Basal cochlear damage was assessed histologically and electrode insertion properties were documented in implanted bones. All implanted specimens showed clear scala tympani electrode placements regardless of cochleostomy technique. All 21 inferior cochleostomies were atraumatic. Anterior-inferior cochleostomies resulted in various degrees of intracochlear trauma in all seven bones. For atraumatic opening of the scala tympani using a cochleostomy approach, initiation of drilling should proceed from inferior to the round window annulus, with gradual progression toward the undersurface of the lumen. While cochleostomies initiated anterior-inferior to the round window annulus resulted in scala tympani opening, many of these bones displayed varying degrees of intracochlear trauma that may result in hearing loss. When intracochlear drilling is avoided, the anterior bony margin of the cochleostomy remains a significant intracochlear impediment to in-line electrode insertion.

Real-time 3-D contrast-enhanced transcranial ultrasound and aberration correction.

PubMed

Ivancevich, Nikolas M; Pinton, Gianmarco F; Nicoletto, Heather A; Bennett, Ellen; Laskowitz, Daniel T; Smith, Stephen W

2008-09-01

Contrast-enhanced (CE) transcranial ultrasound (US) and reconstructed 3-D transcranial ultrasound have shown advantages over traditional methods in a variety of cerebrovascular diseases. We present the results from a novel ultrasound technique, namely real-time 3-D contrast-enhanced transcranial ultrasound. Using real-time 3-D (RT3D) ultrasound and microbubble contrast agent, we scanned 17 healthy volunteers via a single temporal window and nine via the suboccipital window and report our detection rates for the major cerebral vessels. In 71% of subjects, both of our observers identified the ipsilateral circle of Willis from the temporal window, and in 59% we imaged the entire circle of Willis. From the suboccipital window, both observers detected the entire vertebrobasilar circulation in 22% of subjects, and in 44%, the basilar artery. After performing phase aberration correction on one subject, we were able to increase the diagnostic value of the scan, detecting a vessel not present in the uncorrected scan. These preliminary results suggest that RT3D CE transcranial US and RT3D CE transcranial US with phase aberration correction have the potential to greatly impact the field of neurosonology.

Real-Time 3D Contrast-Enhanced Transcranial Ultrasound and Aberration Correction

PubMed Central

Ivancevich, Nikolas M.; Pinton, Gianmarco F.; Nicoletto, Heather A.; Bennett, Ellen; Laskowitz, Daniel T.; Smith, Stephen W.

2008-01-01

Contrast-enhanced (CE) transcranial ultrasound (US) and reconstructed 3D transcranial ultrasound have shown advantages over traditional methods in a variety of cerebrovascular diseases. We present the results from a novel ultrasound technique, namely real-time 3D contrast-enhanced transcranial ultrasound. Using real-time 3D (RT3D) ultrasound and micro-bubble contrast agent, we scanned 17 healthy volunteers via a single temporal window and 9 via the sub-occipital window and report our detection rates for the major cerebral vessels. In 71% of subjects, both of our observers identified the ipsilateral circle of Willis from the temporal window, and in 59% we imaged the entire circle of Willis. From the sub-occipital window, both observers detected the entire vertebrobasilar circulation in 22% of subjects, and in 44% the basilar artery. After performing phase aberration correction on one subject, we were able to increase the diagnostic value of the scan, detecting a vessel not present in the uncorrected scan. These preliminary results suggest that RT3D CE transcranial US and RT3D CE transcranial US with phase aberration correction have the potential to greatly impact the field of neurosonology. PMID:18395321

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fu, Yao, E-mail: Yao.Fu@colorado.edu; Song, Jeong-Hoon, E-mail: JH.Song@colorado.edu

Heat flux expressions are derived for multibody potential systems by extending the original Hardy's methodology and modifying Admal & Tadmor's formulas. The continuum thermomechanical quantities obtained from these two approaches are easy to compute from molecular dynamics (MD) results, and have been tested for a constant heat flux model in two distinctive systems: crystalline iron and polyethylene (PE) polymer. The convergence criteria and affecting parameters, i.e. spatial and temporal window size, and specific forms of localization function are found to be different between the two systems. The conservation of mass, momentum, and energy are discussed and validated within this atomistic–continuummore » bridging.« less

Stress during pregnancy alters temporal and spatial dynamics of the maternal and offspring microbiome in a sex-specific manner

PubMed Central

Jašarević, Eldin; Howard, Christopher D.; Misic, Ana M.; Beiting, Daniel P.; Bale, Tracy L.

2017-01-01

The microbiome is a regulator of host immunity, metabolism, neurodevelopment, and behavior. During early life, bacterial communities within maternal gut and vaginal compartments can have an impact on directing these processes. Maternal stress experience during pregnancy may impact offspring development by altering the temporal and spatial dynamics of the maternal microbiome during pregnancy. To examine the hypothesis that maternal stress disrupts gut and vaginal microbial dynamics during critical prenatal and postnatal windows, we used high-resolution 16S rRNA marker gene sequencing to examine outcomes in our mouse model of early prenatal stress. Consistent with predictions, maternal fecal communities shift across pregnancy, a process that is disrupted by stress. Vaginal bacterial community structure and composition exhibit lasting disruption following stress exposure. Comparison of maternal and offspring microbiota revealed that similarities in bacterial community composition was predicted by a complex interaction between maternal body niche and offspring age and sex. Importantly, early prenatal stress influenced offspring bacterial community assembly in a temporal and sex-specific manner. Taken together, our results demonstrate that early prenatal stress may influence offspring development through converging modifications to gut microbial composition during pregnancy and transmission of dysbiotic vaginal microbiome at birth. PMID:28266645

Using scan statistics for congenital anomalies surveillance: the EUROCAT methodology.

PubMed

Teljeur, Conor; Kelly, Alan; Loane, Maria; Densem, James; Dolk, Helen

2015-11-01

Scan statistics have been used extensively to identify temporal clusters of health events. We describe the temporal cluster detection methodology adopted by the EUROCAT (European Surveillance of Congenital Anomalies) monitoring system. Since 2001, EUROCAT has implemented variable window width scan statistic for detecting unusual temporal aggregations of congenital anomaly cases. The scan windows are based on numbers of cases rather than being defined by time. The methodology is imbedded in the EUROCAT Central Database for annual application to centrally held registry data. The methodology was incrementally adapted to improve the utility and to address statistical issues. Simulation exercises were used to determine the power of the methodology to identify periods of raised risk (of 1-18 months). In order to operationalize the scan methodology, a number of adaptations were needed, including: estimating date of conception as unit of time; deciding the maximum length (in time) and recency of clusters of interest; reporting of multiple and overlapping significant clusters; replacing the Monte Carlo simulation with a lookup table to reduce computation time; and placing a threshold on underlying population change and estimating the false positive rate by simulation. Exploration of power found that raised risk periods lasting 1 month are unlikely to be detected except when the relative risk and case counts are high. The variable window width scan statistic is a useful tool for the surveillance of congenital anomalies. Numerous adaptations have improved the utility of the original methodology in the context of temporal cluster detection in congenital anomalies.

Frequency modulation of neural oscillations according to visual task demands.

PubMed

Wutz, Andreas; Melcher, David; Samaha, Jason

2018-02-06

Temporal integration in visual perception is thought to occur within cycles of occipital alpha-band (8-12 Hz) oscillations. Successive stimuli may be integrated when they fall within the same alpha cycle and segregated for different alpha cycles. Consequently, the speed of alpha oscillations correlates with the temporal resolution of perception, such that lower alpha frequencies provide longer time windows for perceptual integration and higher alpha frequencies correspond to faster sampling and segregation. Can the brain's rhythmic activity be dynamically controlled to adjust its processing speed according to different visual task demands? We recorded magnetoencephalography (MEG) while participants switched between task instructions for temporal integration and segregation, holding stimuli and task difficulty constant. We found that the peak frequency of alpha oscillations decreased when visual task demands required temporal integration compared with segregation. Alpha frequency was strategically modulated immediately before and during stimulus processing, suggesting a preparatory top-down source of modulation. Its neural generators were located in occipital and inferotemporal cortex. The frequency modulation was specific to alpha oscillations and did not occur in the delta (1-3 Hz), theta (3-7 Hz), beta (15-30 Hz), or gamma (30-50 Hz) frequency range. These results show that alpha frequency is under top-down control to increase or decrease the temporal resolution of visual perception.

Combining Temporal and Spectral Information with Spatial Mapping to Identify Differences between Phonological and Semantic Networks: A Magnetoencephalographic Approach

PubMed Central

McNab, Fiona; Hillebrand, Arjan; Swithenby, Stephen J.; Rippon, Gina

2012-01-01

Early, lesion-based models of language processing suggested that semantic and phonological processes are associated with distinct temporal and parietal regions respectively, with frontal areas more indirectly involved. Contemporary spatial brain mapping techniques have not supported such clear-cut segregation, with strong evidence of activation in left temporal areas by both processes and disputed evidence of involvement of frontal areas in both processes. We suggest that combining spatial information with temporal and spectral data may allow a closer scrutiny of the differential involvement of closely overlapping cortical areas in language processing. Using beamforming techniques to analyze magnetoencephalography data, we localized the neuronal substrates underlying primed responses to nouns requiring either phonological or semantic processing, and examined the associated measures of time and frequency in those areas where activation was common to both tasks. Power changes in the beta (14–30 Hz) and gamma (30–50 Hz) frequency bands were analyzed in pre-selected time windows of 350–550 and 500–700 ms In left temporal regions, both tasks elicited power changes in the same time window (350–550 ms), but with different spectral characteristics, low beta (14–20 Hz) for the phonological task and high beta (20–30 Hz) for the semantic task. In frontal areas (BA10), both tasks elicited power changes in the gamma band (30–50 Hz), but in different time windows, 500–700 ms for the phonological task and 350–550 ms for the semantic task. In the left inferior parietal area (BA40), both tasks elicited changes in the 20–30 Hz beta frequency band but in different time windows, 350–550 ms for the phonological task and 500–700 ms for the semantic task. Our findings suggest that, where spatial measures may indicate overlapping areas of involvement, additional beamforming techniques can demonstrate differential activation in time and frequency domains. PMID:22908001

Measurements of Human Middle- and Inner-Ear Mechanics With Dehiscence of the Superior Semicircular Canal

PubMed Central

Chien, Wade; Ravicz, Michael E.; Rosowski, John J.; Merchant, Saumil N.

2008-01-01

Objectives (1) To develop a cadaveric temporal-bone preparation to study the mechanism of hearing loss resulting from superior semicircular canal dehiscence (SCD) and (2) to assess the potential usefulness of clinical measurements of umbo velocity for the diagnosis of SCD. Background The syndrome of dehiscence of the superior semicircular canal is a clinical condition encompassing a variety of vestibular and auditory symptoms, including an air-bone gap at low frequencies. It has been hypothesized that the dehiscence acts as a “third window” into the inner ear that shunts acoustic energy away from the cochlea at low frequencies, causing hearing loss. Methods Sound-induced stapes, umbo, and round-window velocities were measured in prepared temporal bones (n = 8) using laser-Doppler vibrometry (1) with the superior semicircular canal intact, (2) after creation of a dehiscence in the superior canal, and (3) with the dehiscence patched. Clinical measurements of umbo velocity in live SCD ears (n = 29) were compared with similar data from our cadaveric temporal-bone preparations. Results An SCD caused a significant reduction in sound-induced round-window velocity at low frequencies, small but significant increases in sound-induced stapes and umbo velocities, and a measurable fluid velocity inside the dehiscence. The increase in sound-induced umbo velocity in temporal bones was also found to be similar to that measured in the 29 live ears with SCD. Conclusion Findings from the cadaveric temporal-bone preparation were consistent with the third-window hypothesis. In addition, measurement of umbo velocity in live ears is helpful in distinguishing SCD from other otologic pathologies presenting with an air-bone gap (e.g., otosclerosis). PMID:17255894

Multisensory temporal function and EEG complexity in patients with epilepsy and psychogenic nonepileptic events.

PubMed

Noel, Jean-Paul; Kurela, LeAnne; Baum, Sarah H; Yu, Hong; Neimat, Joseph S; Gallagher, Martin J; Wallace, Mark

2017-05-01

Cognitive and perceptual comorbidities frequently accompany epilepsy and psychogenic nonepileptic events (PNEE). However, and despite the fact that perceptual function is built upon a multisensory foundation, little knowledge exists concerning multisensory function in these populations. Here, we characterized facets of multisensory processing abilities in patients with epilepsy and PNEE, and probed the relationship between individual resting-state EEG complexity and these psychophysical measures in each patient. We prospectively studied a cohort of patients with epilepsy (N=18) and PNEE (N=20) patients who were admitted to Vanderbilt's Epilepsy Monitoring Unit (EMU) and weaned off of anticonvulsant drugs. Unaffected age-matched persons staying with the patients in the EMU (N=15) were also recruited as controls. All participants performed two tests of multisensory function: an audio-visual simultaneity judgment and an audio-visual redundant target task. Further, in the cohort of patients with epilepsy and PNEE we quantified resting state EEG gamma power and complexity. Compared with both patients with epilepsy and control subjects, patients with PNEE exhibited significantly poorer acuity in audiovisual temporal function as evidenced in significantly larger temporal binding windows (i.e., they perceived larger stimulus asynchronies as being presented simultaneously). These differences appeared to be specific for temporal function, as there was no difference among the three groups in a non-temporally based measure of multisensory function - the redundant target task. Further, patients with PNEE exhibited more complex resting state EEG patterns as compared to their patients with epilepsy, and EEG complexity correlated with multisensory temporal performance on a subject-by-subject manner. Taken together, findings seem to indicate that patients with PNEE bind information from audition and vision over larger temporal intervals when compared with control subjects as well as patients with epilepsy. This difference in multisensory function appears to be specific to the temporal domain, and may be a contributing factor to the behavioral and perceptual alterations seen in this population. Published by Elsevier Inc.

Generating Daily Synthetic Landsat Imagery by Combining Landsat and MODIS Data

PubMed Central

Wu, Mingquan; Huang, Wenjiang; Niu, Zheng; Wang, Changyao

2015-01-01

Owing to low temporal resolution and cloud interference, there is a shortage of high spatial resolution remote sensing data. To address this problem, this study introduces a modified spatial and temporal data fusion approach (MSTDFA) to generate daily synthetic Landsat imagery. This algorithm was designed to avoid the limitations of the conditional spatial temporal data fusion approach (STDFA) including the constant window for disaggregation and the sensor difference. An adaptive window size selection method is proposed in this study to select the best window size and moving steps for the disaggregation of coarse pixels. The linear regression method is used to remove the influence of differences in sensor systems using disaggregated mean coarse reflectance by testing and validation in two study areas located in Xinjiang Province, China. The results show that the MSTDFA algorithm can generate daily synthetic Landsat imagery with a high correlation coefficient (R) ranged from 0.646 to 0.986 between synthetic images and the actual observations. We further show that MSTDFA can be applied to 250 m 16-day MODIS MOD13Q1 products and the Landsat Normalized Different Vegetation Index (NDVI) data by generating a synthetic NDVI image highly similar to actual Landsat NDVI observation with a high R of 0.97. PMID:26393607

Generating Daily Synthetic Landsat Imagery by Combining Landsat and MODIS Data.

PubMed

Wu, Mingquan; Huang, Wenjiang; Niu, Zheng; Wang, Changyao

2015-09-18

Owing to low temporal resolution and cloud interference, there is a shortage of high spatial resolution remote sensing data. To address this problem, this study introduces a modified spatial and temporal data fusion approach (MSTDFA) to generate daily synthetic Landsat imagery. This algorithm was designed to avoid the limitations of the conditional spatial temporal data fusion approach (STDFA) including the constant window for disaggregation and the sensor difference. An adaptive window size selection method is proposed in this study to select the best window size and moving steps for the disaggregation of coarse pixels. The linear regression method is used to remove the influence of differences in sensor systems using disaggregated mean coarse reflectance by testing and validation in two study areas located in Xinjiang Province, China. The results show that the MSTDFA algorithm can generate daily synthetic Landsat imagery with a high correlation coefficient (R) ranged from 0.646 to 0.986 between synthetic images and the actual observations. We further show that MSTDFA can be applied to 250 m 16-day MODIS MOD13Q1 products and the Landsat Normalized Different Vegetation Index (NDVI) data by generating a synthetic NDVI image highly similar to actual Landsat NDVI observation with a high R of 0.97.

Spatial, temporal, and hybrid decompositions for large-scale vehicle routing with time windows

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bent, Russell W

This paper studies the use of decomposition techniques to quickly find high-quality solutions to large-scale vehicle routing problems with time windows. It considers an adaptive decomposition scheme which iteratively decouples a routing problem based on the current solution. Earlier work considered vehicle-based decompositions that partitions the vehicles across the subproblems. The subproblems can then be optimized independently and merged easily. This paper argues that vehicle-based decompositions, although very effective on various problem classes also have limitations. In particular, they do not accommodate temporal decompositions and may produce spatial decompositions that are not focused enough. This paper then proposes customer-based decompositionsmore » which generalize vehicle-based decouplings and allows for focused spatial and temporal decompositions. Experimental results on class R2 of the extended Solomon benchmarks demonstrates the benefits of the customer-based adaptive decomposition scheme and its spatial, temporal, and hybrid instantiations. In particular, they show that customer-based decompositions bring significant benefits over large neighborhood search in contrast to vehicle-based decompositions.« less

Patterns of anomalies of structures of the middle ear and the facial nerve as revealed in newborn temporal bones.

PubMed

Tóth, Miklós; Sirirattanapan, Jarinratn; Mann, Wolf

2013-08-01

The purpose of this study is to offer new data about facial nerve malformations in the tympanic cavity. Prospective anatomic study of newborns to demonstrate the submacroscopic anatomy of the intratympanic facial nerve and its surrounding structures by malformations. Step-by-step microdissection of 12 newborn temporal bones and histologic evaluation of 4 middle ears showing multiple malformations. Four of 12 temporal bones presented malformation in the middle ear. All 4 temporal bones showed developmental failures of the stapes, and 3 of them had malposition of the tympanic portion of the facial nerve. In 3 cases, there was an oval window atresia, and in 1 case, the rim of the oval window was not ossified and was positioned medial to the stapes. Malformation or displacement of the stapes can be an indirect sign for facial nerve malformation. The most common site for facial nerve malformation is the tympanic portion. The tympanic segment of the nerve is devoid of bony covering in association with these anomalies of the stapes.

Dynamic Reorganization of Functional Connectivity Reveals Abnormal Temporal Efficiency in Schizophrenia.

PubMed

Sun, Yu; Collinson, Simon L; Suckling, John; Sim, Kang

2018-06-07

Emerging evidence suggests that schizophrenia is associated with brain dysconnectivity. Nonetheless, the implicit assumption of stationary functional connectivity (FC) adopted in most previous resting-state functional magnetic resonance imaging (fMRI) studies raises an open question of schizophrenia-related aberrations in dynamic properties of resting-state FC. This study introduces an empirical method to examine the dynamic functional dysconnectivity in patients with schizophrenia. Temporal brain networks were estimated from resting-state fMRI of 2 independent datasets (patients/controls = 18/19 and 53/57 for self-recorded dataset and a publicly available replication dataset, respectively) by the correlation of sliding time-windowed time courses among regions of a predefined atlas. Through the newly introduced temporal efficiency approach and temporal random network models, we examined, for the first time, the 3D spatiotemporal architecture of the temporal brain network. We found that although prominent temporal small-world properties were revealed in both groups, temporal brain networks of patients with schizophrenia in both datasets showed a significantly higher temporal global efficiency, which cannot be simply attributable to head motion and sampling error. Specifically, we found localized changes of temporal nodal properties in the left frontal, right medial parietal, and subcortical areas that were associated with clinical features of schizophrenia. Our findings demonstrate that altered dynamic FC may underlie abnormal brain function and clinical symptoms observed in schizophrenia. Moreover, we provide new evidence to extend the dysconnectivity hypothesis in schizophrenia from static to dynamic brain network and highlight the potential of aberrant brain dynamic FC in unraveling the pathophysiologic mechanisms of the disease.

Listeners modulate temporally selective attention during natural speech processing

PubMed Central

Astheimer, Lori B.; Sanders, Lisa D.

2009-01-01

Spatially selective attention allows for the preferential processing of relevant stimuli when more information than can be processed in detail is presented simultaneously at distinct locations. Temporally selective attention may serve a similar function during speech perception by allowing listeners to allocate attentional resources to time windows that contain highly relevant acoustic information. To test this hypothesis, event-related potentials were compared in response to attention probes presented in six conditions during a narrative: concurrently with word onsets, beginning 50 and 100 ms before and after word onsets, and at random control intervals. Times for probe presentation were selected such that the acoustic environments of the narrative were matched for all conditions. Linguistic attention probes presented at and immediately following word onsets elicited larger amplitude N1s than control probes over medial and anterior regions. These results indicate that native speakers selectively process sounds presented at specific times during normal speech perception. PMID:18395316

Electrophysiological Source Imaging: A Noninvasive Window to Brain Dynamics.

PubMed

He, Bin; Sohrabpour, Abbas; Brown, Emery; Liu, Zhongming

2018-06-04

Brain activity and connectivity are distributed in the three-dimensional space and evolve in time. It is important to image brain dynamics with high spatial and temporal resolution. Electroencephalography (EEG) and magnetoencephalography (MEG) are noninvasive measurements associated with complex neural activations and interactions that encode brain functions. Electrophysiological source imaging estimates the underlying brain electrical sources from EEG and MEG measurements. It offers increasingly improved spatial resolution and intrinsically high temporal resolution for imaging large-scale brain activity and connectivity on a wide range of timescales. Integration of electrophysiological source imaging and functional magnetic resonance imaging could further enhance spatiotemporal resolution and specificity to an extent that is not attainable with either technique alone. We review methodological developments in electrophysiological source imaging over the past three decades and envision its future advancement into a powerful functional neuroimaging technology for basic and clinical neuroscience applications.

GPS or travel diary: Comparing spatial and temporal characteristics of visits to fast food restaurants and supermarkets

PubMed Central

Vernez Moudon, Anne; Hurvitz, Philip M.; Aggarwal, Anju; Drewnowski, Adam

2017-01-01

To assess differences between GPS and self-reported measures of location, we examined visits to fast food restaurants and supermarkets using a spatiotemporal framework. Data came from 446 participants who responded to a survey, filled out travel diaries of places visited, and wore a GPS receiver for seven consecutive days. Provided by Public Health Seattle King County, addresses from food permit data were matched to King County tax assessor parcels in a GIS. A three-step process was used to verify travel-diary reported visits using GPS records: (1) GPS records were temporally matched if their timestamps were within the time window created by the arrival and departure times reported in the travel diary; (2) the temporally matched GPS records were then spatially matched if they were located in a food establishment parcel of the same type reported in the diary; (3) the travel diary visit was then GPS-sensed if the name of food establishment in the parcel matched the one reported in the travel diary. To account for errors in reporting arrival and departure times, GPS records were temporally matched to three time windows: the exact time, +/- 10 minutes, and +/- 30 minutes. One third of the participants reported 273 visits to fast food restaurants; 88% reported 1,102 visits to supermarkets. Of these, 77.3 percent of the fast food and 78.6 percent supermarket visits were GPS-sensed using the +/-10-minute time window. At this time window, the mean travel-diary reported fast food visit duration was 14.5 minutes (SD 20.2), 1.7 minutes longer than the GPS-sensed visit. For supermarkets, the reported visit duration was 23.7 minutes (SD 18.9), 3.4 minutes longer than the GPS-sensed visit. Travel diaries provide reasonably accurate information on the locations and brand names of fast food restaurants and supermarkets participants report visiting. PMID:28388619

GPS or travel diary: Comparing spatial and temporal characteristics of visits to fast food restaurants and supermarkets.

PubMed

Scully, Jason Y; Vernez Moudon, Anne; Hurvitz, Philip M; Aggarwal, Anju; Drewnowski, Adam

2017-01-01

To assess differences between GPS and self-reported measures of location, we examined visits to fast food restaurants and supermarkets using a spatiotemporal framework. Data came from 446 participants who responded to a survey, filled out travel diaries of places visited, and wore a GPS receiver for seven consecutive days. Provided by Public Health Seattle King County, addresses from food permit data were matched to King County tax assessor parcels in a GIS. A three-step process was used to verify travel-diary reported visits using GPS records: (1) GPS records were temporally matched if their timestamps were within the time window created by the arrival and departure times reported in the travel diary; (2) the temporally matched GPS records were then spatially matched if they were located in a food establishment parcel of the same type reported in the diary; (3) the travel diary visit was then GPS-sensed if the name of food establishment in the parcel matched the one reported in the travel diary. To account for errors in reporting arrival and departure times, GPS records were temporally matched to three time windows: the exact time, +/- 10 minutes, and +/- 30 minutes. One third of the participants reported 273 visits to fast food restaurants; 88% reported 1,102 visits to supermarkets. Of these, 77.3 percent of the fast food and 78.6 percent supermarket visits were GPS-sensed using the +/-10-minute time window. At this time window, the mean travel-diary reported fast food visit duration was 14.5 minutes (SD 20.2), 1.7 minutes longer than the GPS-sensed visit. For supermarkets, the reported visit duration was 23.7 minutes (SD 18.9), 3.4 minutes longer than the GPS-sensed visit. Travel diaries provide reasonably accurate information on the locations and brand names of fast food restaurants and supermarkets participants report visiting.

TH-CD-207B-03: How to Quantify Temporal Resolution in X-Ray MDCT Imaging?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Budde, A; GE Healthcare Technologies, Madison, WI; Li, Y

Purpose: In modern CT scanners, a quantitative metric to assess temporal response, namely, to quantify the temporal resolution (TR), remains elusive. Rough surrogate metrics, such as half of the gantry rotation time for single source CT, a quarter of the gantry rotation time for dual source CT, or measurements of motion artifact’s size, shape, or intensity have previously been used. In this work, a rigorous framework which quantifies TR and a practical measurement method are developed. Methods: A motion phantom was simulated which consisted of a single rod that is in motion except during a static period at the temporalmore » center of the scan, termed the TR window. If the image of the motion scan has negligible motion artifacts compared to an image from a totally static scan, then the system has a TR no worse than the TR window used. By repeating this comparison with varying TR windows, the TR of the system can be accurately determined. Motion artifacts were also visually assessed and the TR was measured across varying rod motion speeds, directions, and locations. Noiseless fan beam acquisitions were simulated and images were reconstructed with a short-scan image reconstruction algorithm. Results: The size, shape, and intensity of motion artifacts varied when the rod speed, direction, or location changed. TR measured using the proposed method, however, was consistent across rod speeds, directions, and locations. Conclusion: Since motion artifacts vary depending upon the motion speed, direction, and location, they are not suitable for measuring TR. In this work, a CT system with a specified TR is defined as having the ability to produce a static image with negligible motion artifacts, no matter what motion occurs outside of a static window of width TR. This framework allows for practical measurement of temporal resolution in clinical CT imaging systems. Funding support: GE Healthcare; Conflict of Interest: Employee, GE Healthcare.« less

Noise-induced hearing loss increases the temporal precision of complex envelope coding by auditory-nerve fibers

PubMed Central

Henry, Kenneth S.; Kale, Sushrut; Heinz, Michael G.

2014-01-01

While changes in cochlear frequency tuning are thought to play an important role in the perceptual difficulties of people with sensorineural hearing loss (SNHL), the possible role of temporal processing deficits remains less clear. Our knowledge of temporal envelope coding in the impaired cochlea is limited to two studies that examined auditory-nerve fiber responses to narrowband amplitude modulated stimuli. In the present study, we used Wiener-kernel analyses of auditory-nerve fiber responses to broadband Gaussian noise in anesthetized chinchillas to quantify changes in temporal envelope coding with noise-induced SNHL. Temporal modulation transfer functions (TMTFs) and temporal windows of sensitivity to acoustic stimulation were computed from 2nd-order Wiener kernels and analyzed to estimate the temporal precision, amplitude, and latency of envelope coding. Noise overexposure was associated with slower (less negative) TMTF roll-off with increasing modulation frequency and reduced temporal window duration. The results show that at equal stimulus sensation level, SNHL increases the temporal precision of envelope coding by 20–30%. Furthermore, SNHL increased the amplitude of envelope coding by 50% in fibers with CFs from 1–2 kHz and decreased mean response latency by 0.4 ms. While a previous study of envelope coding demonstrated a similar increase in response amplitude, the present study is the first to show enhanced temporal precision. This new finding may relate to the use of a more complex stimulus with broad frequency bandwidth and a dynamic temporal envelope. Exaggerated neural coding of fast envelope modulations may contribute to perceptual difficulties in people with SNHL by acting as a distraction from more relevant acoustic cues, especially in fluctuating background noise. Finally, the results underscore the value of studying sensory systems with more natural, real-world stimuli. PMID:24596545

Visual awareness suppression by pre-stimulus brain stimulation; a neural effect.

PubMed

Jacobs, Christianne; Goebel, Rainer; Sack, Alexander T

2012-01-02

Transcranial magnetic stimulation (TMS) has established the functional relevance of early visual cortex (EVC) for visual awareness with great temporal specificity non-invasively in conscious human volunteers. Many studies have found a suppressive effect when TMS was applied over EVC 80-100 ms after the onset of the visual stimulus (post-stimulus TMS time window). Yet, few studies found task performance to also suffer when TMS was applied even before visual stimulus presentation (pre-stimulus TMS time window). This pre-stimulus TMS effect, however, remains controversially debated and its origin had mainly been ascribed to TMS-induced eye-blinking artifacts. Here, we applied chronometric TMS over EVC during the execution of a visual discrimination task, covering an exhaustive range of visual stimulus-locked TMS time windows ranging from -80 pre-stimulus to 300 ms post-stimulus onset. Electrooculographical (EoG) recordings, sham TMS stimulation, and vertex TMS stimulation controlled for different types of non-neural TMS effects. Our findings clearly reveal TMS-induced masking effects for both pre- and post-stimulus time windows, and for both objective visual discrimination performance and subjective visibility. Importantly, all effects proved to be still present after post hoc removal of eye blink trials, suggesting a neural origin for the pre-stimulus TMS suppression effect on visual awareness. We speculate based on our data that TMS exerts its pre-stimulus effect via generation of a neural state which interacts with subsequent visual input. Copyright © 2011 Elsevier Inc. All rights reserved.

Identification of a hybridization window that facilitates sizeable reductions of pollen-mediated gene flow in spring wheat.

PubMed

Willenborg, Christian J; Brûlé-Babel, Anita L; Van Acker, Rene C

2010-06-01

Transgenic wheat (Triticum aestivum L.) with improved agronomic traits is currently being field-tested. Gene flow in space is well-documented, but isolation in time has not received comparable attention. Here, we report the results of a field experiment that investigated reductions in intraspecific gene flow associated with temporal isolation of flowering between T. aestivum conspecifics. Pollen-mediated gene flow (PMGF) between an imazamox-resistant (IR) volunteer wheat population and a non-IR spring wheat crop was assessed over a range of volunteer emergence timings and plant population densities that collectively promoted flowering asynchrony. Natural hybridization events between the two populations were detected by phenotypically scoring plants in F(1) populations followed by verification with Mendelian segregation ratios in the F(1:2) lines. Based on the examination of >545,000 seedlings, we identified a hybridization window in spring wheat approximately 125 growing degree-days (GDD) in length. We found a sizeable reduction (two- to four-fold) in gene flow frequencies when flowering occurred outside of this window. The hybridization window identified in this research also will serve to temporally isolate neighboring wheat crops. However, strict control of volunteer populations or spatial isolation of neighbouring crops emerging within a 125 GDD hybridization window will be necessary to maintain low frequencies of PMGF in spring wheat fields. The model developed herein also is likely to be applicable to other wind-pollinated species.

Threshold model of cascades in empirical temporal networks

NASA Astrophysics Data System (ADS)

Karimi, Fariba; Holme, Petter

2013-08-01

Threshold models try to explain the consequences of social influence like the spread of fads and opinions. Along with models of epidemics, they constitute a major theoretical framework of social spreading processes. In threshold models on static networks, an individual changes her state if a certain fraction of her neighbors has done the same. When there are strong correlations in the temporal aspects of contact patterns, it is useful to represent the system as a temporal network. In such a system, not only contacts but also the time of the contacts are represented explicitly. In many cases, bursty temporal patterns slow down disease spreading. However, as we will see, this is not a universal truth for threshold models. In this work we propose an extension of Watts’s classic threshold model to temporal networks. We do this by assuming that an agent is influenced by contacts which lie a certain time into the past. I.e., the individuals are affected by contacts within a time window. In addition to thresholds in the fraction of contacts, we also investigate the number of contacts within the time window as a basis for influence. To elucidate the model’s behavior, we run the model on real and randomized empirical contact datasets.

Timing of androgen receptor disruption and estrogen exposure underlies a spectrum of congenital penile anomalies

PubMed Central

Armfield, Brooke A.; Cohn, Martin J.

2015-01-01

Congenital penile anomalies (CPAs) are among the most common human birth defects. Reports of CPAs, which include hypospadias, chordee, micropenis, and ambiguous genitalia, have risen sharply in recent decades, but the causes of these malformations are rarely identified. Both genetic anomalies and environmental factors, such as antiandrogenic and estrogenic endocrine disrupting chemicals (EDCs), are suspected to cause CPAs; however, little is known about the temporal window(s) of sensitivity to EDCs, or the tissue-specific roles and downstream targets of the androgen receptor (AR) in external genitalia. Here, we show that the full spectrum of CPAs can be produced by disrupting AR at different developmental stages and in specific cell types in the mouse genital tubercle. Inactivation of AR during a narrow window of prenatal development results in hypospadias and chordee, whereas earlier disruptions cause ambiguous genitalia and later disruptions cause micropenis. The neonatal phase of penile development is controlled by the balance of AR to estrogen receptor α (ERα) activity; either inhibition of androgen or augmentation of estrogen signaling can induce micropenis. AR and ERα have opposite effects on cell division, apoptosis, and regulation of Hedgehog, fibroblast growth factor, bone morphogenetic protein, and Wnt signaling in the genital tubercle. We identify Indian hedgehog (Ihh) as a novel downstream target of AR in external genitalia and show that conditional deletion of Ihh inhibits penile masculinization. These studies reveal previously unidentified cellular and molecular mechanisms by which antiandrogenic and estrogenic signals induce penile malformations and demonstrate that the timing of endocrine disruption can determine the type of CPA. PMID:26598695

The sense of body ownership relaxes temporal constraints for multisensory integration.

PubMed

Maselli, Antonella; Kilteni, Konstantina; López-Moliner, Joan; Slater, Mel

2016-08-03

Experimental work on body ownership illusions showed how simple multisensory manipulation can generate the illusory experience of an artificial limb as being part of the own-body. This work highlighted how own-body perception relies on a plastic brain representation emerging from multisensory integration. The flexibility of this representation is reflected in the short-term modulations of physiological states and perceptual processing observed during these illusions. Here, we explore the impact of ownership illusions on the temporal dimension of multisensory integration. We show that, during the illusion, the temporal window for integrating touch on the physical body with touch seen on a virtual body representation, increases with respect to integration with visual events seen close but separated from the virtual body. We show that this effect is mediated by the ownership illusion. Crucially, the temporal window for visuotactile integration was positively correlated with participants' scores rating the illusory experience of owning the virtual body and touching the object seen in contact with it. Our results corroborate the recently proposed causal inference mechanism for illusory body ownership. As a novelty, they show that the ensuing illusory causal binding between stimuli from the real and fake body relaxes constraints for the integration of bodily signals.

Effects of Spatio-Temporal Aliasing on Out-the-Window Visual Systems

NASA Technical Reports Server (NTRS)

Sweet, Barbara T.; Stone, Leland S.; Liston, Dorion B.; Hebert, Tim M.

2014-01-01

Designers of out-the-window visual systems face a challenge when attempting to simulate the outside world as viewed from a cockpit. Many methodologies have been developed and adopted to aid in the depiction of particular scene features, or levels of static image detail. However, because aircraft move, it is necessary to also consider the quality of the motion in the simulated visual scene. When motion is introduced in the simulated visual scene, perceptual artifacts can become apparent. A particular artifact related to image motion, spatiotemporal aliasing, will be addressed. The causes of spatio-temporal aliasing will be discussed, and current knowledge regarding the impact of these artifacts on both motion perception and simulator task performance will be reviewed. Methods of reducing the impact of this artifact are also addressed

Rapid, experience-dependent translation of neurogranin enables memory encoding.

PubMed

Jones, Kendrick J; Templet, Sebastian; Zemoura, Khaled; Kuzniewska, Bozena; Pena, Franciso X; Hwang, Hongik; Lei, Ding J; Haensgen, Henny; Nguyen, Shannon; Saenz, Christopher; Lewis, Michael; Dziembowska, Magdalena; Xu, Weifeng

2018-06-19

Experience induces de novo protein synthesis in the brain and protein synthesis is required for long-term memory. It is important to define the critical temporal window of protein synthesis and identify newly synthesized proteins required for memory formation. Using a behavioral paradigm that temporally separates the contextual exposure from the association with fear, we found that protein synthesis during the transient window of context exposure is required for contextual memory formation. Among an array of putative activity-dependent translational neuronal targets tested, we identified one candidate, a schizophrenia-associated candidate mRNA, neurogranin (Ng, encoded by the Nrgn gene) responding to novel-context exposure. The Ng mRNA was recruited to the actively translating mRNA pool upon novel-context exposure, and its protein levels were rapidly increased in the hippocampus. By specifically blocking activity-dependent translation of Ng using virus-mediated molecular perturbation, we show that experience-dependent translation of Ng in the hippocampus is required for contextual memory formation. We further interrogated the molecular mechanism underlying the experience-dependent translation of Ng, and found that fragile-X mental retardation protein (FMRP) interacts with the 3'UTR of the Nrgn mRNA and is required for activity-dependent translation of Ng in the synaptic compartment and contextual memory formation. Our results reveal that FMRP-mediated, experience-dependent, rapid enhancement of Ng translation in the hippocampus during the memory acquisition enables durable context memory encoding. Copyright © 2018 the Author(s). Published by PNAS.

Rapid, experience-dependent translation of neurogranin enables memory encoding

PubMed Central

Jones, Kendrick J.; Templet, Sebastian; Zemoura, Khaled; Pena, Franciso X.; Hwang, Hongik; Lei, Ding J.; Haensgen, Henny; Nguyen, Shannon; Saenz, Christopher; Lewis, Michael; Dziembowska, Magdalena

2018-01-01

Experience induces de novo protein synthesis in the brain and protein synthesis is required for long-term memory. It is important to define the critical temporal window of protein synthesis and identify newly synthesized proteins required for memory formation. Using a behavioral paradigm that temporally separates the contextual exposure from the association with fear, we found that protein synthesis during the transient window of context exposure is required for contextual memory formation. Among an array of putative activity-dependent translational neuronal targets tested, we identified one candidate, a schizophrenia-associated candidate mRNA, neurogranin (Ng, encoded by the Nrgn gene) responding to novel-context exposure. The Ng mRNA was recruited to the actively translating mRNA pool upon novel-context exposure, and its protein levels were rapidly increased in the hippocampus. By specifically blocking activity-dependent translation of Ng using virus-mediated molecular perturbation, we show that experience-dependent translation of Ng in the hippocampus is required for contextual memory formation. We further interrogated the molecular mechanism underlying the experience-dependent translation of Ng, and found that fragile-X mental retardation protein (FMRP) interacts with the 3′UTR of the Nrgn mRNA and is required for activity-dependent translation of Ng in the synaptic compartment and contextual memory formation. Our results reveal that FMRP-mediated, experience-dependent, rapid enhancement of Ng translation in the hippocampus during the memory acquisition enables durable context memory encoding. PMID:29880715

Orienting attention in visual space by nociceptive stimuli: investigation with a temporal order judgment task based on the adaptive PSI method.

PubMed

Filbrich, Lieve; Alamia, Andrea; Burns, Soline; Legrain, Valéry

2017-07-01

Despite their high relevance for defending the integrity of the body, crossmodal links between nociception, the neural system specifically coding potentially painful information, and vision are still poorly studied, especially the effects of nociception on visual perception. This study investigated if, and in which time window, a nociceptive stimulus can attract attention to its location on the body, independently of voluntary control, to facilitate the processing of visual stimuli occurring in the same side of space as the limb on which the visual stimulus was applied. In a temporal order judgment task based on an adaptive procedure, participants judged which of two visual stimuli, one presented next to either hand in either side of space, had been perceived first. Each pair of visual stimuli was preceded (by 200, 400, or 600 ms) by a nociceptive stimulus applied either unilaterally on one single hand, or bilaterally, on both hands simultaneously. Results show that, as compared to the bilateral condition, participants' judgments were biased to the advantage of the visual stimuli that occurred in the same side of space as the hand on which a unilateral, nociceptive stimulus was applied. This effect was present in a time window ranging from 200 to 600 ms, but importantly, biases increased with decreasing time interval. These results suggest that nociceptive stimuli can affect the perceptual processing of spatially congruent visual inputs.

Prognostic models based on patient snapshots and time windows: Predicting disease progression to assisted ventilation in Amyotrophic Lateral Sclerosis.

PubMed

Carreiro, André V; Amaral, Pedro M T; Pinto, Susana; Tomás, Pedro; de Carvalho, Mamede; Madeira, Sara C

2015-12-01

Amyotrophic Lateral Sclerosis (ALS) is a devastating disease and the most common neurodegenerative disorder of young adults. ALS patients present a rapidly progressive motor weakness. This usually leads to death in a few years by respiratory failure. The correct prediction of respiratory insufficiency is thus key for patient management. In this context, we propose an innovative approach for prognostic prediction based on patient snapshots and time windows. We first cluster temporally-related tests to obtain snapshots of the patient's condition at a given time (patient snapshots). Then we use the snapshots to predict the probability of an ALS patient to require assisted ventilation after k days from the time of clinical evaluation (time window). This probability is based on the patient's current condition, evaluated using clinical features, including functional impairment assessments and a complete set of respiratory tests. The prognostic models include three temporal windows allowing to perform short, medium and long term prognosis regarding progression to assisted ventilation. Experimental results show an area under the receiver operating characteristics curve (AUC) in the test set of approximately 79% for time windows of 90, 180 and 365 days. Creating patient snapshots using hierarchical clustering with constraints outperforms the state of the art, and the proposed prognostic model becomes the first non population-based approach for prognostic prediction in ALS. The results are promising and should enhance the current clinical practice, largely supported by non-standardized tests and clinicians' experience. Copyright © 2015 Elsevier Inc. All rights reserved.

The impact of water loading on postglacial decay times in Hudson Bay

NASA Astrophysics Data System (ADS)

Han, Holly Kyeore; Gomez, Natalya

2018-05-01

Ongoing glacial isostatic adjustment (GIA) due to surface loading (ice and water) variations during the last glacial cycle has been contributing to sea-level changes globally throughout the Holocene, especially in regions like Canada that were heavily glaciated during the Last Glacial Maximum (LGM). The spatial and temporal distribution of GIA, as manifested in relative sea-level (RSL) change, are sensitive to the ice history and the rheological structure of the solid Earth, both of which are uncertain. It has been shown that RSL curves near the center of previously glaciated regions with no ongoing surface loading follow an exponential-like form, with the postglacial decay times associated with that form having a weak sensitivity to the details of the ice loading history. Postglacial decay time estimates thus provide a powerful datum for constraining the Earth's viscous structure and improving GIA predictions. We explore spatial patterns of postglacial decay time predictions in Hudson Bay by decomposing numerically modeled RSL changes into contributions from water and ice loading effects, and computing their relative impact on the decay times. We demonstrate that ice loading can contribute a strong geographic trend on the decay time estimates if the time window used to compute decay times includes periods that are temporally close to (i.e. contemporaneous with, or soon after) periods of active loading. This variability can be avoided by choosing a suitable starting point for the decay time window. However, more surprisingly, we show that across any adopted time window, water loading effects associated with inundation into, and postglacial flux out of, Hudson Bay and James Bay will impart significant geographic variability onto decay time estimates. We emphasize this issue by considering both maps of predicted decay times across the region and site-specific estimates, and we conclude that variability in observed decay times (whether based on existing or future data sets) may reflect this water loading signal.

Femtosecond optical packet generation by a direct space-to-time pulse shaper.

PubMed

Leaird, D E; Weiner, A M

1999-06-15

We demonstrate femtosecond operation of a direct space-to-time pulse shaper in which there is direct mapping (no Fourier transform) between the spatial position of the masking function and the temporal position in the output waveform. We use this apparatus to generate trains of 20 pulses as an ultrafast optical data packet over an approximately 40-ps temporal window.

Alterations in audiovisual simultaneity perception in amblyopia

PubMed Central

2017-01-01

Amblyopia is a developmental visual impairment that is increasingly recognized to affect higher-level perceptual and multisensory processes. To further investigate the audiovisual (AV) perceptual impairments associated with this condition, we characterized the temporal interval in which asynchronous auditory and visual stimuli are perceived as simultaneous 50% of the time (i.e., the AV simultaneity window). Adults with unilateral amblyopia (n = 17) and visually normal controls (n = 17) judged the simultaneity of a flash and a click presented with both eyes viewing. The signal onset asynchrony (SOA) varied from 0 ms to 450 ms for auditory-lead and visual-lead conditions. A subset of participants with amblyopia (n = 6) was tested monocularly. Compared to the control group, the auditory-lead side of the AV simultaneity window was widened by 48 ms (36%; p = 0.002), whereas that of the visual-lead side was widened by 86 ms (37%; p = 0.02). The overall mean window width was 500 ms, compared to 366 ms among controls (37% wider; p = 0.002). Among participants with amblyopia, the simultaneity window parameters were unchanged by viewing condition, but subgroup analysis revealed differential effects on the parameters by amblyopia severity, etiology, and foveal suppression status. Possible mechanisms to explain these findings include visual temporal uncertainty, interocular perceptual latency asymmetry, and disruption of normal developmental tuning of sensitivity to audiovisual asynchrony. PMID:28598996

Alterations in audiovisual simultaneity perception in amblyopia.

PubMed

Richards, Michael D; Goltz, Herbert C; Wong, Agnes M F

2017-01-01

Amblyopia is a developmental visual impairment that is increasingly recognized to affect higher-level perceptual and multisensory processes. To further investigate the audiovisual (AV) perceptual impairments associated with this condition, we characterized the temporal interval in which asynchronous auditory and visual stimuli are perceived as simultaneous 50% of the time (i.e., the AV simultaneity window). Adults with unilateral amblyopia (n = 17) and visually normal controls (n = 17) judged the simultaneity of a flash and a click presented with both eyes viewing. The signal onset asynchrony (SOA) varied from 0 ms to 450 ms for auditory-lead and visual-lead conditions. A subset of participants with amblyopia (n = 6) was tested monocularly. Compared to the control group, the auditory-lead side of the AV simultaneity window was widened by 48 ms (36%; p = 0.002), whereas that of the visual-lead side was widened by 86 ms (37%; p = 0.02). The overall mean window width was 500 ms, compared to 366 ms among controls (37% wider; p = 0.002). Among participants with amblyopia, the simultaneity window parameters were unchanged by viewing condition, but subgroup analysis revealed differential effects on the parameters by amblyopia severity, etiology, and foveal suppression status. Possible mechanisms to explain these findings include visual temporal uncertainty, interocular perceptual latency asymmetry, and disruption of normal developmental tuning of sensitivity to audiovisual asynchrony.

A Window into the Brain: Advances in Psychiatric fMRI

PubMed Central

Zhan, Xiaoyan

2015-01-01

Functional magnetic resonance imaging (fMRI) plays a key role in modern psychiatric research. It provides a means to assay differences in brain systems that underlie psychiatric illness, treatment response, and properties of brain structure and function that convey risk factor for mental diseases. Here we review recent advances in fMRI methods in general use and progress made in understanding the neural basis of mental illness. Drawing on concepts and findings from psychiatric fMRI, we propose that mental illness may not be associated with abnormalities in specific local regions but rather corresponds to variation in the overall organization of functional communication throughout the brain network. Future research may need to integrate neuroimaging information drawn from different analysis methods and delineate spatial and temporal patterns of brain responses that are specific to certain types of psychiatric disorders. PMID:26413531

Auditory processing efficiency deficits in children with developmental language impairments

NASA Astrophysics Data System (ADS)

Hartley, Douglas E. H.; Moore, David R.

2002-12-01

The ``temporal processing hypothesis'' suggests that individuals with specific language impairments (SLIs) and dyslexia have severe deficits in processing rapidly presented or brief sensory information, both within the auditory and visual domains. This hypothesis has been supported through evidence that language-impaired individuals have excess auditory backward masking. This paper presents an analysis of masking results from several studies in terms of a model of temporal resolution. Results from this modeling suggest that the masking results can be better explained by an ``auditory efficiency'' hypothesis. If impaired or immature listeners have a normal temporal window, but require a higher signal-to-noise level (poor processing efficiency), this hypothesis predicts the observed small deficits in the simultaneous masking task, and the much larger deficits in backward and forward masking tasks amongst those listeners. The difference in performance on these masking tasks is predictable from the compressive nonlinearity of the basilar membrane. The model also correctly predicts that backward masking (i) is more prone to training effects, (ii) has greater inter- and intrasubject variability, and (iii) increases less with masker level than do other masking tasks. These findings provide a new perspective on the mechanisms underlying communication disorders and auditory masking.

Characterization of the dimensional stability of advanced metallic materials using an optical test bench structure

NASA Technical Reports Server (NTRS)

Hsieh, Cheng; O'Donnell, Timothy P.

1991-01-01

The dimensional stability of low-density high specific-strength metal-matrix composites (including 30 vol pct SiC(p)/SXA 24-T6 Al, 25 vol pct SiC(p)/6061-T6 Al, 40 vol pct graphite P100 fiber/6061 Al, 50 vol pct graphite P100 fiber/6061 Al, and 40 vol pct P100 graphite fiber/AZ91D Mg composites) and an Al-Li-Mg metal alloy was evaluated using a specially designed five-strut optical test bench structure. The structure had 30 thermocouple locations, one retroreflector, one linear interferometer multilayer insulation, and various strip heaters. It was placed in a 10 exp -7 torr capability vacuum chamber with a laser head positioned at a window port, and a laser interferometer system for collecting dimensional change data. It was found that composite materials have greater 40-C temporal dimensional stability than the AL-Li-Mg alloy. Aluminum-based composites demonstrated better 40-C temporal stability than Mg-based composites.

Time-Coordination Strategies and Control Laws for Multi-Agent Unmanned Systems

NASA Technical Reports Server (NTRS)

Puig-Navarro, Javier; Hovakimyan, Naira; Allen, B. Danette

2017-01-01

Time-critical coordination tools for unmanned systems can be employed to enforce the type of temporal constraints required in terminal control areas, ensure minimum distance requirements among vehicles are satisfied, and successfully perform coordinated missions. In comparison with previous literature, this paper presents an ampler spectrum of coordination and temporal specifications for unmanned systems, and proposes a general control law that can enforce this range of constraints. The constraint classification presented con- siders the nature of the desired arrival window and the permissible coordination errors to define six different types of time-coordination strategies. The resulting decentralized coordination control law allows the vehicles to negotiate their speeds along their paths in response to information exchanged over the communication network. This control law organizes the different members in the fleet hierarchically per their behavior and informational needs as reference agent, leaders, and followers. Examples and simulation results for all the coordination strategies presented demonstrate the applicability and efficacy of the coordination control law for multiple unmanned systems.

Time-Hierarchical Clustering and Visualization of Weather Forecast Ensembles.

PubMed

Ferstl, Florian; Kanzler, Mathias; Rautenhaus, Marc; Westermann, Rudiger

2017-01-01

We propose a new approach for analyzing the temporal growth of the uncertainty in ensembles of weather forecasts which are started from perturbed but similar initial conditions. As an alternative to traditional approaches in meteorology, which use juxtaposition and animation of spaghetti plots of iso-contours, we make use of contour clustering and provide means to encode forecast dynamics and spread in one single visualization. Based on a given ensemble clustering in a specified time window, we merge clusters in time-reversed order to indicate when and where forecast trajectories start to diverge. We present and compare different visualizations of the resulting time-hierarchical grouping, including space-time surfaces built by connecting cluster representatives over time, and stacked contour variability plots. We demonstrate the effectiveness of our visual encodings with forecast examples of the European Centre for Medium-Range Weather Forecasts, which convey the evolution of specific features in the data as well as the temporally increasing spatial variability.

Testing a simplified method for measuring velocity integration in saccades using a manipulation of target contrast.

PubMed

Etchells, Peter J; Benton, Christopher P; Ludwig, Casimir J H; Gilchrist, Iain D

2011-01-01

A growing number of studies in vision research employ analyses of how perturbations in visual stimuli influence behavior on single trials. Recently, we have developed a method along such lines to assess the time course over which object velocity information is extracted on a trial-by-trial basis in order to produce an accurate intercepting saccade to a moving target. Here, we present a simplified version of this methodology, and use it to investigate how changes in stimulus contrast affect the temporal velocity integration window used when generating saccades to moving targets. Observers generated saccades to one of two moving targets which were presented at high (80%) or low (7.5%) contrast. In 50% of trials, target velocity stepped up or down after a variable interval after the saccadic go signal. The extent to which the saccade endpoint can be accounted for as a weighted combination of the pre- or post-step velocities allows for identification of the temporal velocity integration window. Our results show that the temporal integration window takes longer to peak in the low when compared to high contrast condition. By enabling the assessment of how information such as changes in velocity can be used in the programming of a saccadic eye movement on single trials, this study describes and tests a novel methodology with which to look at the internal processing mechanisms that transform sensory visual inputs into oculomotor outputs.

Ube3a reinstatement identifies distinct developmental windows in a murine Angelman syndrome model

PubMed Central

Silva-Santos, Sara; van Woerden, Geeske M.; Bruinsma, Caroline F.; Mientjes, Edwin; Jolfaei, Mehrnoush Aghadavoud; Distel, Ben; Kushner, Steven A.; Elgersma, Ype

2015-01-01

Angelman syndrome (AS) is a severe neurodevelopmental disorder that results from loss of function of the maternal ubiquitin protein ligase E3A (UBE3A) allele. Due to neuron-specific imprinting, the paternal UBE3A copy is silenced. Previous studies in murine models have demonstrated that strategies to activate the paternal Ube3a allele are feasible; however, a recent study showed that pharmacological Ube3a gene reactivation in adulthood failed to rescue the majority of neurocognitive phenotypes in a murine AS model. Here, we performed a systematic study to investigate the possibility that neurocognitive rescue can be achieved by reinstating Ube3a during earlier neurodevelopmental windows. We developed an AS model that allows for temporally controlled Cre-dependent induction of the maternal Ube3a allele and determined that there are distinct neurodevelopmental windows during which Ube3a restoration can rescue AS-relevant phenotypes. Motor deficits were rescued by Ube3a reinstatement in adolescent mice, whereas anxiety, repetitive behavior, and epilepsy were only rescued when Ube3a was reinstated during early development. In contrast, hippocampal synaptic plasticity could be restored at any age. Together, these findings suggest that Ube3a reinstatement early in development may be necessary to prevent or rescue most AS-associated phenotypes and should be considered in future clinical trial design. PMID:25866966

Retinoic acid temporally orchestrates colonization of the gut by vagal neural crest cells.

PubMed

Uribe, Rosa A; Hong, Stephanie S; Bronner, Marianne E

2018-01-01

The enteric nervous system arises from neural crest cells that migrate as chains into and along the primitive gut, subsequently differentiating into enteric neurons and glia. Little is known about the mechanisms governing neural crest migration en route to and along the gut in vivo. Here, we report that Retinoic Acid (RA) temporally controls zebrafish enteric neural crest cell chain migration. In vivo imaging reveals that RA loss severely compromises the integrity and migration of the chain of neural crest cells during the window of time window when they are moving along the foregut. After loss of RA, enteric progenitors accumulate in the foregut and differentiate into enteric neurons, but subsequently undergo apoptosis resulting in a striking neuronal deficit. Moreover, ectopic expression of the transcription factor meis3 and/or the receptor ret, partially rescues enteric neuron colonization after RA attenuation. Collectively, our findings suggest that retinoic acid plays a critical temporal role in promoting enteric neural crest chain migration and neuronal survival upstream of Meis3 and RET in vivo. Copyright © 2017 Elsevier Inc. All rights reserved.

CoinCalc-A new R package for quantifying simultaneities of event series

NASA Astrophysics Data System (ADS)

Siegmund, Jonatan F.; Siegmund, Nicole; Donner, Reik V.

2017-01-01

We present the new R package CoinCalc for performing event coincidence analysis (ECA), a novel statistical method to quantify the simultaneity of events contained in two series of observations, either as simultaneous or lagged coincidences within a user-specific temporal tolerance window. The package also provides different analytical as well as surrogate-based significance tests (valid under different assumptions about the nature of the observed event series) as well as an intuitive visualization of the identified coincidences. We demonstrate the usage of CoinCalc based on two typical geoscientific example problems addressing the relationship between meteorological extremes and plant phenology as well as that between soil properties and land cover.

Impact of coupling techniques of an active middle ear device to the round window membrane for the backward stimulation of the cochlea.

PubMed

Gostian, Antoniu-Oreste; Pazen, David; Ortmann, Magdalene; Luers, Jan-Christoffer; Anagiotos, Andreas; Hüttenbrink, Karl-Bernd; Beutner, Dirk

2015-01-01

Interposed cartilage and the round window coupler (RWC) increase the efficiency of cochlea stimulation with the floating mass transducer (FMT) of a single active middle ear implant (AMEI) placed against the round window membrane. Treatment of mixed and conductive hearing loss with an AMEI attached to the round window is effective, yet the best placement technique of its FMT for the most efficient stimulation of the cochlea remains to be determined. Experimental study on human temporal bones with the FMT placed against firstly the unaltered round window niche and then subsequently against the fully exposed round window membrane with and without interposed cartilage and the RWC. Cochlea stimulation is measured by the volume velocities of the stapes footplate using LASER vibrometry. At the undrilled round window niche, placement of the FMT by itself and with the RWC resulted in similar volume velocities. The response was significantly raised by interposing cartilage into the undrilled round window niche. Complete exposure of the round window membrane allowed for significantly increased volume velocities. Among these, coupling of the FMT with interposed cartilage yielded responses of similar magnitude compared with the RWC but significantly higher compared with the FMT by itself. Good contact to the round window membrane is essential for efficient stimulation of the cochlea. Therefore, interposing cartilage into the undrilled round window niche is a viable option. At the drilled round window membrane, the FMT with interposed cartilage and attached to the RWC are similarly effective.

Femtosecond direct space-to-time pulse shaping in an integrated-optic configuration.

PubMed

Leaird, D E; Weiner, A M

2004-07-01

We demonstrate femtosecond operation of an integrated-optic direct space-to-time pulse shaper for which there is a direct mapping (no Fourier transform) between the spatial position of the masking function and the temporal position in the output waveform. The apparatus is used to generate trains of more than 30 pulses as an ultrafast optical data packet over approximately an 80-ps temporal window.

Creation of a 3D printed temporal bone model from clinical CT data.

PubMed

Cohen, Joss; Reyes, Samuel A

2015-01-01

Generate and describe the process of creating a 3D printed, rapid prototype temporal bone model from clinical quality CT images. We describe a technique to create an accurate, alterable, and reproducible rapid prototype temporal bone model using freely available software to segment clinical CT data and generate three different 3D models composed of ABS plastic. Each model was evaluated based on the appearance and size of anatomical structures and response to surgical drilling. Mastoid air cells had retained scaffolding material in the initial versions. This required modifying the model to allow drainage of the scaffolding material. External auditory canal dimensions were similar to those measured from the clinical data. Malleus, incus, oval window, round window, promontory, horizontal semicircular canal, and mastoid segment of the facial nerve canal were identified in all models. The stapes was only partially formed in two models and absent in the third. Qualitative feel of the ABS plastic was softer than bone. The pate produced by drilling was similar to bone dust when appropriate irrigation was used. We present a rapid prototype temporal bone model made based on clinical CT data using 3D printing technology. The model can be made quickly and inexpensively enough to have potential applications for educational training. Copyright © 2015 Elsevier Inc. All rights reserved.

The Temporal Courses of Phonological and Orthographic Encoding in Handwritten Production in Chinese: An ERP Study

PubMed Central

Zhang, Qingfang; Wang, Cheng

2016-01-01

A central issue in written production concerns how phonological codes influence the output of orthographic codes. We used a picture-word interference paradigm combined with the event-related potential technique to investigate the temporal courses of phonological and orthographic activation and their interplay in Chinese writing. Distractors were orthographically related, phonologically related, orthographically plus phonologically related, or unrelated to picture names. The behavioral results replicated the classic facilitation effect for all three types of relatedness. The ERP results indicated an orthographic effect in the time window of 370–500 ms (onset latency: 370 ms), a phonological effect in the time window of 460–500 ms (onset latency: 464 ms), and an additive pattern of both effects in both time windows, thus indicating that orthographic codes were accessed earlier than, and independent of, phonological codes in written production. The orthographic activation originates from the semantic system, whereas the phonological effect results from the activation spreading from the orthographic lexicon to the phonological lexicon. These findings substantially strengthen the existing evidence that shows that access to orthographic codes is not mediated by phonological information, and they provide important support for the orthographic autonomy hypothesis. PMID:27605911

Neural activity in the posterior superior temporal region during eye contact perception correlates with autistic traits.

PubMed

Hasegawa, Naoya; Kitamura, Hideaki; Murakami, Hiroatsu; Kameyama, Shigeki; Sasagawa, Mutsuo; Egawa, Jun; Endo, Taro; Someya, Toshiyuki

2013-08-09

The present study investigated the relationship between neural activity associated with gaze processing and autistic traits in typically developed subjects using magnetoencephalography. Autistic traits in 24 typically developed college students with normal intelligence were assessed using the Autism Spectrum Quotient (AQ). The Minimum Current Estimates method was applied to estimate the cortical sources of magnetic responses to gaze stimuli. These stimuli consisted of apparent motion of the eyes, displaying direct or averted gaze motion. Results revealed gaze-related brain activations in the 150-250 ms time window in the right posterior superior temporal sulcus (pSTS), and in the 150-450 ms time window in medial prefrontal regions. In addition, the mean amplitude in the 150-250 ms time window in the right pSTS region was modulated by gaze direction, and its activity in response to direct gaze stimuli correlated with AQ score. pSTS activation in response to direct gaze is thought to be related to higher-order social processes. Thus, these results suggest that brain activity linking eye contact and social signals is associated with autistic traits in a typical population. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Audiovisual integration in depth: multisensory binding and gain as a function of distance.

PubMed

Noel, Jean-Paul; Modi, Kahan; Wallace, Mark T; Van der Stoep, Nathan

2018-07-01

The integration of information across sensory modalities is dependent on the spatiotemporal characteristics of the stimuli that are paired. Despite large variation in the distance over which events occur in our environment, relatively little is known regarding how stimulus-observer distance affects multisensory integration. Prior work has suggested that exteroceptive stimuli are integrated over larger temporal intervals in near relative to far space, and that larger multisensory facilitations are evident in far relative to near space. Here, we sought to examine the interrelationship between these previously established distance-related features of multisensory processing. Participants performed an audiovisual simultaneity judgment and redundant target task in near and far space, while audiovisual stimuli were presented at a range of temporal delays (i.e., stimulus onset asynchronies). In line with the previous findings, temporal acuity was poorer in near relative to far space. Furthermore, reaction time to asynchronously presented audiovisual targets suggested a temporal window for fast detection-a range of stimuli asynchronies that was also larger in near as compared to far space. However, the range of reaction times over which multisensory response enhancement was observed was limited to a restricted range of relatively small (i.e., 150 ms) asynchronies, and did not differ significantly between near and far space. Furthermore, for synchronous presentations, these distance-related (i.e., near vs. far) modulations in temporal acuity and multisensory gain correlated negatively at an individual subject level. Thus, the findings support the conclusion that multisensory temporal binding and gain are asymmetrically modulated as a function of distance from the observer, and specifies that this relationship is specific for temporally synchronous audiovisual stimulus presentations.

In vivo imaging of cancer cell size and cellularity using temporal diffusion spectroscopy.

PubMed

Jiang, Xiaoyu; Li, Hua; Xie, Jingping; McKinley, Eliot T; Zhao, Ping; Gore, John C; Xu, Junzhong

2017-07-01

A temporal diffusion MRI spectroscopy based approach has been developed to quantify cancer cell size and density in vivo. A novel imaging microstructural parameters using limited spectrally edited diffusion (IMPULSED) method selects a specific limited diffusion spectral window for an accurate quantification of cell sizes ranging from 10 to 20 μm in common solid tumors. In practice, it is achieved by a combination of a single long diffusion time pulsed gradient spin echo (PGSE) and three low-frequency oscillating gradient spin echo (OGSE) acquisitions. To validate our approach, hematoxylin and eosin staining and immunostaining of cell membranes, in concert with whole slide imaging, were used to visualize nuclei and cell boundaries, and hence, enabled accurate estimates of cell size and cellularity. Based on a two compartment model (incorporating intra- and extracellular spaces), accurate estimates of cell sizes were obtained in vivo for three types of human colon cancers. The IMPULSED-derived apparent cellularities showed a stronger correlation (r = 0.81; P < 0.0001) with histology-derived cellularities than conventional ADCs (r = -0.69; P < 0.03). The IMPULSED approach samples a specific region of temporal diffusion spectra with enhanced sensitivity to length scales of 10-20 μm, and enables measurements of cell sizes and cellularities in solid tumors in vivo. Magn Reson Med 78:156-164, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

Roles for Coincidence Detection in Coding Amplitude-Modulated Sounds

PubMed Central

Ashida, Go; Kretzberg, Jutta; Tollin, Daniel J.

2016-01-01

Many sensory neurons encode temporal information by detecting coincident arrivals of synaptic inputs. In the mammalian auditory brainstem, binaural neurons of the medial superior olive (MSO) are known to act as coincidence detectors, whereas in the lateral superior olive (LSO) roles of coincidence detection have remained unclear. LSO neurons receive excitatory and inhibitory inputs driven by ipsilateral and contralateral acoustic stimuli, respectively, and vary their output spike rates according to interaural level differences. In addition, LSO neurons are also sensitive to binaural phase differences of low-frequency tones and envelopes of amplitude-modulated (AM) sounds. Previous physiological recordings in vivo found considerable variations in monaural AM-tuning across neurons. To investigate the underlying mechanisms of the observed temporal tuning properties of LSO and their sources of variability, we used a simple coincidence counting model and examined how specific parameters of coincidence detection affect monaural and binaural AM coding. Spike rates and phase-locking of evoked excitatory and spontaneous inhibitory inputs had only minor effects on LSO output to monaural AM inputs. In contrast, the coincidence threshold of the model neuron affected both the overall spike rates and the half-peak positions of the AM-tuning curve, whereas the width of the coincidence window merely influenced the output spike rates. The duration of the refractory period affected only the low-frequency portion of the monaural AM-tuning curve. Unlike monaural AM coding, temporal factors, such as the coincidence window and the effective duration of inhibition, played a major role in determining the trough positions of simulated binaural phase-response curves. In addition, empirically-observed level-dependence of binaural phase-coding was reproduced in the framework of our minimalistic coincidence counting model. These modeling results suggest that coincidence detection of excitatory and inhibitory synaptic inputs is essential for LSO neurons to encode both monaural and binaural AM sounds. PMID:27322612

Measuring oxygen tension modulation, induced by a new pre-radiotherapy therapeutic, in a mammary window chamber mouse model

NASA Astrophysics Data System (ADS)

Schafer, Rachel; Gmitro, Arthur F.

2015-03-01

Tumor regions under hypoxic or low oxygen conditions respond less effectively to many treatment strategies, including radiation therapy. A novel investigational therapeutic, NVX-108 (NuvOx Pharma), has been developed to increase delivery of oxygen through the use of a nano-emulsion of dodecofluoropentane. By raising pO2 levels prior to delivering radiation, treatment efficacy may be improved. To aid in evaluating the novel drug, oxygen tension was quantitatively measured, spatially and temporally, to record the effect of administrating NVX-108 in an orthotopic mammary window chamber mouse model of breast cancer. The oxygen tension was measured through the use of an oxygen-sensitive coating, comprised of phosphorescent platinum porphyrin dye embedded in a polystyrene matrix. The coating, applied to the surface of the coverslip of the window chamber through spin coating, is placed in contact with the mammary fat pad to record the oxygenation status of the surface tissue layer. Prior to implantation of the window chamber, a tumor is grown in the SCID mouse model by injection of MCF-7 cells into the mammary fat pad. Two-dimensional spatial distributions of the pO2 levels were obtained through conversion of measured maps of phosphorescent lifetime. The resulting information on the spatial and temporal variation of the induced oxygen modulation could provide valuable insight into the optimal timing between administration of NVX-108 and radiation treatment to provide the most effective treatment outcome.

An investigation of chaotic Kolmogorov flows

NASA Technical Reports Server (NTRS)

Platt, N.; Sirovich, L.; Fitzmaurice, N.

1990-01-01

A two dimensional flow governed by the incompressible Navier-Stokes equations with a steady spatially periodic forcing (known as the Kolmogorov flow) is numerically simulated. The behavior of the flow and its transition states as the Reynolds number (Re) varies is investigated in detail, as well as a number of the flow features. A sequence of bifurcations is shown to take place in the flow as Re varied. Two main regimes of the flow were observed: small and large scale structure regimes corresponding to different ranges of Re. Each of the regimes includes a number of quasiperiodic, chaotic, and relaminarization windows. In addition, each range contains a chaotic window with non-ergodic chaotic attractors. Spatially disordered, but temporally steady states were discovered in large scale structure regime. Features of the diverse cases are displayed in terms of the temporal power spectrum, Poincare sections and, where possible, Lyapunov exponents and Kaplan-Yorke dimension.

Functional magnetic resonance imaging phase synchronization as a measure of dynamic functional connectivity.

PubMed

Glerean, Enrico; Salmi, Juha; Lahnakoski, Juha M; Jääskeläinen, Iiro P; Sams, Mikko

2012-01-01

Functional brain activity and connectivity have been studied by calculating intersubject and seed-based correlations of hemodynamic data acquired with functional magnetic resonance imaging (fMRI). To inspect temporal dynamics, these correlation measures have been calculated over sliding time windows with necessary restrictions on the length of the temporal window that compromises the temporal resolution. Here, we show that it is possible to increase temporal resolution by using instantaneous phase synchronization (PS) as a measure of dynamic (time-varying) functional connectivity. We applied PS on an fMRI dataset obtained while 12 healthy volunteers watched a feature film. Narrow frequency band (0.04-0.07 Hz) was used in the PS analysis to avoid artifactual results. We defined three metrics for computing time-varying functional connectivity and time-varying intersubject reliability based on estimation of instantaneous PS across the subjects: (1) seed-based PS, (2) intersubject PS, and (3) intersubject seed-based PS. Our findings show that these PS-based metrics yield results consistent with both seed-based correlation and intersubject correlation methods when inspected over the whole time series, but provide an important advantage of maximal single-TR temporal resolution. These metrics can be applied both in studies with complex naturalistic stimuli (e.g., watching a movie or listening to music in the MRI scanner) and more controlled (e.g., event-related or blocked design) paradigms. A MATLAB toolbox FUNPSY ( http://becs.aalto.fi/bml/software.html ) is openly available for using these metrics in fMRI data analysis.

Management of Temporal Constraints for Factory Scheduling.

DTIC Science & Technology

1987-06-01

consistency of scheduling decisions were implemented in both the ISIS [Fox 84] and SOJA [LePape 85a] scheduling systems. More recent work with the...kinds of time propagation systems: the symbolic and the numeric ones. Symbolic systems combine relationships with a temporal logic a la Allen [Allen 81...maintains consistency by narrowing time windows associated with activities as decisions are made, and SOJA [LePape 85b] guarantees a schedule’s

Sex differences in prenatal epigenetic programming of stress pathways.

PubMed

Bale, Tracy L

2011-07-01

Maternal stress experience is associated with neurodevelopmental disorders including schizophrenia and autism. Recent studies have examined mechanisms by which changes in the maternal milieu may be transmitted to the developing embryo and potentially translated into programming of the epigenome. Animal models of prenatal stress have identified important sex- and temporal-specific effects on offspring stress responsivity. As dysregulation of stress pathways is a common feature in most neuropsychiatric diseases, molecular and epigenetic analyses at the maternal-embryo interface, especially in the placenta, may provide unique insight into identifying much-needed predictive biomarkers. In addition, as most neurodevelopmental disorders present with a sex bias, examination of sex differences in the inheritance of phenotypic outcomes may pinpoint gene targets and specific windows of vulnerability in neurodevelopment, which have been disrupted. This review discusses the association and possible contributing mechanisms of prenatal stress in programming offspring stress pathway dysregulation and the importance of sex.

Theta Oscillations Rapidly Convey Odor-Specific Content in Human Piriform Cortex.

PubMed

Jiang, Heidi; Schuele, Stephan; Rosenow, Joshua; Zelano, Christina; Parvizi, Josef; Tao, James X; Wu, Shasha; Gottfried, Jay A

2017-04-05

Olfactory oscillations are pervasive throughout vertebrate and invertebrate nervous systems. Such observations have long implied that rhythmic activity patterns play a fundamental role in odor coding. Using intracranial EEG recordings from rare patients with medically resistant epilepsy, we find that theta oscillations are a distinct electrophysiological signature of olfactory processing in the human brain. Across seven patients, odor stimulation enhanced theta power in human piriform cortex, with robust effects at the level of single trials. Importantly, classification analysis revealed that piriform oscillatory activity conveys olfactory-specific information that can be decoded within 110-518 ms of a sniff, and maximally within the theta frequency band. This temporal window was also associated with increased theta-specific phase coupling between piriform cortex and hippocampus. Together these findings suggest that human piriform cortex has access to olfactory content in the time-frequency domain and can utilize these signals to rapidly differentiate odor stimuli. Copyright © 2017 Elsevier Inc. All rights reserved.

Retrofacial approach to access the round window for cochlear implantation of malformed ears.

PubMed

Rizk, Habib; O'Connell, Brendan; Stevens, Shawn; Meyer, Ted

2015-03-01

To report the use of the retrofacial approach for cochlear implantation in three cases of malformed ears with inaccessible round windows through the standard facial recess. Two children with bilateral profound sensorineural hearing loss who were cochlear implant candidates. One patient had bilateral sequential cochlear implantations and the other a unilateral implant. Retrofacial approach to access the posterior mesotympanum and visualize the round window. Ability to complete the surgery with full insertion of the implant and no complications such as facial nerve injury. We implanted three ears in two patients with multiple external and middle ear malformations with an aberrant facial nerve or a posteriorly displaced round window niche. The standard facial recess approach did not allow visualization of the round window. We resorted to a retrofacial approach to access the posterior mesotympanum and proceeded with the surgery through an anterior and inferior cochleostomy or through the round window. In cases with an aberrant facial nerve or inaccessible round window through the facial recess, the retrofacial approach is a good alternative but requires a certain level of expertise and familiarity with temporal bone anatomy. The decision to use an unconventional approach should be considered before surgery, but the ultimate decision may require intraoperative assessment.

Comparison of a spatio-temporal speleothem-based reconstruction of late Holocene climate variability to the timing of cultural developments

NASA Astrophysics Data System (ADS)

Deininger, Michael; Lippold, Jörg; Abele, Florian; McDermott, Frank

2016-04-01

Speleothems are considered as a valuable continental climate archive. Their δ18O records provide information onto past changes of the atmospheric circulation accompanied by changes in surface air temperature and precipitation. During the last decades European speleothem studies have assembled a European speleothem network (including numerous speleothem δ18O records) that allow now not only to picture past climate variability in time but also in space. In particular the climate variability of the last 4.5 ka was investigated by these studies. This allows the comparison of the speleothem-based reconstructed palaeoclimate with the timings of the rise and fall of ancient civilisations in this period - including the Dark Ages. Here we evaluate a compilation of 10 speleothem δ18O records covering the last 4.5 ka using a Monte Carlo based Principal Component Analysis (MC-PCA) that accounts for uncertainties in individual speleothem age models and for the different and varying temporal resolutions of each speleothem δ18O record. Our MC-PCA approach allows not only the identification of temporally coherent changes in δ18O records, i.e. the common signal in all investigated speleothem δ18O records, but it also facilitates their depiction and evaluation spatially. The speleothem δ18O records are spanning almost the entire European continent ranging from the western Margin of the European continent to Northern Turkey and from Northern Italy to Norway. For the MC-PCA analysis the 4.5 ka are divided into eight 1ka long time windows that overlap the subsequent time window by 500 years to allow a comparison of the spatio-temporal evolution of the common signal. For every single time window we derive a common mode of climate variability of all speleothem δ18O records as well as its spatial extent. This allows us to compare the rise and fall of ancient civilisations, like the Hittite and the Roman Empire, with our reconstructed spatio-temporal record.

Systematic analysis of nonlinear ground motion and temporal changes of material properties produced by small and medium earthquakes

NASA Astrophysics Data System (ADS)

Wu, C.; Peng, Z.; Ben-Zion, Y.

2009-12-01

Recent studies based on spectral ratio analysis have found clear temporal changes of material properties in the shallow crust and around active fault zones during large earthquakes with peak ground acceleration (PGA) larger than 100-200 gals (e.g., Sawazaki et al., GRL, 2006; Rubenstein et al., JGR, 2007; Wu et al., GJI, 2009). The temporal evolution of properties is generally characterized by a clear drop of resonant frequency and increased damping, followed by logarithmic recoveries with time. The shift in resonant frequency and damping are considered two hallmarks of nonlinear response associated with increasing material damage. However, an existing damage can produce similar changes in resonance curves with increasing wave amplitude, even in cases when the material damage does not increase (Lyakhovsky et al., GJI, 2009). In such cases the recovery of resonance properties with reduced source amplitude should be essentially instantaneous. It is important to distinguish with in situ seismic data nonlinear wave propagation effects that reflect fixed vs. evolving material damage. Here we systematically analyze temporal changes of material properties and nonlinear response associated with small and medium earthquakes, using seismic data recorded by the Japanese Strong Motion Network KIK-Net, a temporary 10-station PASSCAL seismic network along the North Anatolian Fault in Turkey, and the borehole and surface stations around the Parkfield section of the San Andreas fault. We compute the spectral ratios of windowed records from a pair of target and reference stations, and apply the sliding-window to the entire seismic records including the pre-event noise, P and S waves, and the early and late S-coda waves. We choose small and medium events to reduce the effects from additional material damage and use small sliding-window size to capture the subtle changes in the spectral ratios. The spectral ratio traces from windows within certain PGA ranges are then stacked to enhance the stability of the results. The preliminary results from the KIK-Net data suggest that the resonant frequency starts to decrease for PGA levels of several tens of gals, followed by near instantaneous recovery. Updated results from analysis of all the datasets will be presented in the meeting.

SU-E-J-126: Respiratory Gating Quality Assurance: A Simple Method to Achieve Millisecond Temporal Resolution

DOE Office of Scientific and Technical Information (OSTI.GOV)

McCabe, B; Wiersma, R

Purpose: Low temporal latency between a gating on/off signal and a linac beam on/off during respiratory gating is critical for patient safety. Although, a measurement of temporal lag is recommended by AAPM Task Group 142 for commissioning and annual quality assurance, there currently exists no published method. Here we describe a simple, inexpensive, and reliable method to precisely measure gating lag at millisecond resolutions. Methods: A Varian Real-time Position Management™ (RPM) gating simulator with rotating disk was modified with a resistive flex sensor (Spectra Symbol) attached to the gating box platform. A photon diode was placed at machine isocenter. Outputmore » signals of the flex sensor and diode were monitored with a multichannel oscilloscope (Tektronix™ DPO3014). Qualitative inspection of the gating window/beam on synchronicity were made by setting the linac to beam on/off at end-expiration, and the oscilloscope's temporal window to 100 ms to visually examine if the on/off timing was within the recommended 100-ms tolerance. Quantitative measurements were made by saving the signal traces and analyzing in MatLab™. The on and off of the beam signal were located and compared to the expected gating window (e.g. 40% to 60%). Four gating cycles were measured and compared. Results: On a Varian TrueBeam™ STx linac with RPM gating software, the average difference in synchronicity at beam on and off for four cycles was 14 ms (3 to 30 ms) and 11 ms (2 to 32 ms), respectively. For a Varian Clinac™ 21EX the average difference at beam on and off was 127 ms (122 to 133 ms) and 46 ms (42 to 49 ms), respectively. The uncertainty in the synchrony difference was estimated at ±6 ms. Conclusion: This new gating QA method is easy to implement and allows for fast qualitative inspection and quantitative measurements for commissioning and TG-142 annual QA measurements.« less

Congenital amusia.

PubMed

Williamson, Victoria J; Stewart, Lauren

2013-01-01

For most people, music, like language, is acquired effortlessly in early life. But a few percent of the population have lifelong difficulties in the perception and production of music. In this chapter we discuss psycho-acoustic and behavioral studies that have attempted to delineate the nature of the auditory perceptual deficits in this group and consider whether these difficulties extend outside the musical domain. Finally, we review structural imaging studies in this group which point to subtle anomalies in temporal and frontal areas. We suggest that amusia can be considered a disorder of neural development, which has relatively specific consequences at the behavioral level. Studies of congenital amusia provide a unique window on the neurocognitive architecture of music processing. Copyright © 2013 Elsevier B.V. All rights reserved.

Impact of Audio-Visual Asynchrony on Lip-Reading Effects -Neuromagnetic and Psychophysical Study-

PubMed Central

Yahata, Izumi; Kanno, Akitake; Sakamoto, Shuichi; Takanashi, Yoshitaka; Takata, Shiho; Nakasato, Nobukazu; Kawashima, Ryuta; Katori, Yukio

2016-01-01

The effects of asynchrony between audio and visual (A/V) stimuli on the N100m responses of magnetoencephalography in the left hemisphere were compared with those on the psychophysical responses in 11 participants. The latency and amplitude of N100m were significantly shortened and reduced in the left hemisphere by the presentation of visual speech as long as the temporal asynchrony between A/V stimuli was within 100 ms, but were not significantly affected with audio lags of -500 and +500 ms. However, some small effects were still preserved on average with audio lags of 500 ms, suggesting similar asymmetry of the temporal window to that observed in psychophysical measurements, which tended to be more robust (wider) for audio lags; i.e., the pattern of visual-speech effects as a function of A/V lag observed in the N100m in the left hemisphere grossly resembled that in psychophysical measurements on average, although the individual responses were somewhat varied. The present results suggest that the basic configuration of the temporal window of visual effects on auditory-speech perception could be observed from the early auditory processing stage. PMID:28030631

Visual information for judging temporal range

NASA Technical Reports Server (NTRS)

Kaiser, Mary K.; Mowafy, Lyn

1993-01-01

Work in our laboratory suggests that pilots can extract temporal range information (i.e., the time to pass a given waypoint) directly from out-the-window motion information. This extraction does not require the use of velocity or distance, but rather operates solely on a 2-D motion cue. In this paper, we present the mathematical derivation of this information, psychophysical evidence of human observers' sensitivity, and possible advantages and limitations of basing vehicle control on this parameter.

Applied anatomy of round window and adjacent structures of tympanum related to cochlear implantation.

PubMed

Jain, Shraddha; Gaurkar, Sagar; Deshmukh, Prasad T; Khatri, Mohnish; Kalambe, Sanika; Lakhotia, Pooja; Chandravanshi, Deepshikha; Disawal, Ashish

2018-04-19

Various aspects of the round window anatomy and anatomy of posterior tympanum have relevant implications for designing cochlear implant electrodes and visualizing the round window through facial recess. Preoperative information about possible anatomical variations of the round window and its relationships to the adjacent neurovascular structures can help reduce complications in cochlear implant surgery. The present study was undertaken to assess the common variations in round window anatomy and the relationships to structures of the tympanum that may be relevant for cochlear implant surgery. Thirty-five normal wet human cadaveric temporal bones were studied by dissection for anatomy of round window and its relation to facial nerve, carotid canal, jugular fossa and other structures of posterior tympanum. The dissected bones were photographed by a digital camera of 18 megapixels, which were then imported to a computer to determine various parameters using ScopyDoc 8.0.0.22 version software, after proper calibration and at 1× magnification. When the round window niche is placed posteriorly and inferiorly, the distance between round window and vertical facial nerve decreases, whereas that with horizontal facial nerve increases. In such cases, the distance between oval window and round window also increases. Maximum height of the round window in our study ranged from 0.51-1.27mm (mean of 0.69±0.25mm). Maximum width of round window ranged from 0.51 to 2.04mm (mean of 1.16±0.47mm). Average minimum distance between round window and carotid canal was 3.71±0.88mm (range of 2.79-5.34mm) and that between round window and jugular fossa was 2.47±0.9mm (range of 1.24-4.3mm). The distances from the round window to the oval window and facial nerve are important parameters in identifying a difficult round window niche. Modification of the electrode may be a better option than drilling off the round window margins for insertion of cochlear implant electrodes. Copyright © 2018 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.

SNR and functional sensitivity of BOLD and perfusion-based fMRI using arterial spin labeling with spiral SENSE at 3 T.

PubMed

Perthen, Joanna E; Bydder, Mark; Restom, Khaled; Liu, Thomas T

2008-05-01

Blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) studies using parallel imaging to reduce the readout window have reported a loss in temporal signal-to-noise ratio (SNR) that is less than would be expected given a purely thermal noise model. In this study, the impact of parallel imaging on the noise components and functional sensitivity of both BOLD and perfusion-based fMRI data was investigated. Dual-echo arterial spin labeling data were acquired on five subjects using sensitivity encoding (SENSE), at reduction factors (R) of 1, 2 and 3. Direct recording of cardiac and respiratory activity during data acquisition enabled the retrospective removal of physiological noise. The temporal SNR of the perfusion time series closely followed the thermal noise prediction of a radicalR loss in SNR as the readout window was shortened, with temporal SNR values (relative to the R=1 data) of 0.72 and 0.56 for the R=2 and R=3 data, respectively, after accounting for physiological noise. However, the BOLD temporal SNR decreased more slowly than predicted even after accounting for physiological noise, with relative temporal SNR values of 0.80 and 0.63 for the R=2 and R=3 data, respectively. Spectral analysis revealed that the BOLD trends were dominated by low-frequency fluctuations, which were not dominant in the perfusion data due to signal processing differences. The functional sensitivity, assessed using mean F values over activated regions of interest (ROIs), followed the temporal SNR trends for the BOLD data. However, results for the perfusion data were more dependent on the threshold used for ROI selection, most likely due to the inherently low SNR of functional perfusion data.

Multiscale field-aligned current analyzer

NASA Astrophysics Data System (ADS)

Bunescu, C.; Marghitu, O.; Constantinescu, D.; Narita, Y.; Vogt, J.; Blǎgǎu, A.

2015-11-01

The magnetosphere-ionosphere coupling is achieved, essentially, by a superposition of quasi-stationary and time-dependent field-aligned currents (FACs), over a broad range of spatial and temporal scales. The planarity of the FAC structures observed by satellite data and the orientation of the planar FAC sheets can be investigated by the well-established minimum variance analysis (MVA) of the magnetic perturbation. However, such investigations are often constrained to a predefined time window, i.e., to a specific scale of the FAC. The multiscale field-aligned current analyzer, introduced here, relies on performing MVA continuously and over a range of scales by varying the width of the analyzing window, appropriate for the complexity of the magnetic field signatures above the auroral oval. The proposed technique provides multiscale information on the planarity and orientation of the observed FACs. A new approach, based on the derivative of the largest eigenvalue of the magnetic variance matrix with respect to the length of the analysis window, makes possible the inference of the current structures' location (center) and scale (thickness). The capabilities of the FAC analyzer are explored analytically for the magnetic field profile of the Harris sheet and tested on synthetic FAC structures with uniform current density and infinite or finite geometry in the cross-section plane of the FAC. The method is illustrated with data observed by the Cluster spacecraft on crossing the nightside auroral region, and the results are cross checked with the optical observations from the Time History of Events and Macroscale Interactions during Substorms ground network.

Synaptic consolidation as a temporally variable process: Uncovering the parameters modulating its time-course.

PubMed

Casagrande, Mirelle A; Haubrich, Josué; Pedraza, Lizeth K; Popik, Bruno; Quillfeldt, Jorge A; de Oliveira Alvares, Lucas

2018-04-01

Memories are not instantly created in the brain, requiring a gradual stabilization process called consolidation to be stored and persist in a long-lasting manner. However, little is known whether this time-dependent process is dynamic or static, and the factors that might modulate it. Here, we hypothesized that the time-course of consolidation could be affected by specific learning parameters, changing the time window where memory is susceptible to retroactive interference. In the rodent contextual fear conditioning paradigm, we compared weak and strong training protocols and found that in the latter memory is susceptible to post-training hippocampal inactivation for a shorter period of time. The accelerated consolidation process triggered by the strong training was mediated by glucocorticoids, since this effect was blocked by pre-training administration of metyrapone. In addition, we found that pre-exposure to the training context also accelerates fear memory consolidation. Hence, our results demonstrate that the time window in which memory is susceptible to post-training interferences varies depending on fear conditioning intensity and contextual familiarity. We propose that the time-course of memory consolidation is dynamic, being directly affected by attributes of the learning experiences. Copyright © 2018 Elsevier Inc. All rights reserved.

Towards a portable Raman spectrometer using a concave grating and a time-gated CMOS SPAD.

PubMed

Li, Zhiyun; Deen, M Jamal

2014-07-28

A low-cost, compact Raman spectrometer suitable for the on-line water monitoring applications is explored. A custom-designed concave grating for wavelength selection was fabricated and tested. The detection of the Raman signal is accomplished with a time-gated single photon avalanche diode (TG-SPAD). A fixed gate window of 3.5ns is designed and applied to the TG-SPAD. The temporal resolution of the SPAD was ~60ps when tested with a 7ps, 532nm solid-state laser. To test the efficiency of the gating in fluorescence signal suppression, different detection windows (3ns-0.25ns) within the 3.5ns gate window are used to measure the Raman spectra of Rhodamine B. Strong Raman peaks are resolved with this low-cost system.

Extracting temporal and spatial information from remotely sensed data for mapping wildlife habitat: Tucson

USGS Publications Warehouse

Wallace, Cynthia S.A.; Advised by Marsh, Stuart E.

2002-01-01

The research accomplished in this dissertation used both mathematical and statistical techniques to extract and evaluate measures of landscape temporal dynamics and spatial structure from remotely sensed data for the purpose of mapping wildlife habitat. By coupling the landscape measures gleaned from the remotely sensed data with various sets of animal sightings and population data, effective models of habitat preference were created.Measures of temporal dynamics of vegetation greenness as measured by National Oceanographic and Atmospheric Administration’s Advanced Very High Resolution Radiometer (AVHRR) satellite were used to effectively characterize and map season specific habitat of the Sonoran pronghorn antelope, as well as produce preliminary models of potential yellow-billed cuckoo habitat in Arizona. Various measures that capture different aspects of the temporal dynamics of the landscape were derived from AVHRR Normalized Difference Vegetation Index composite data using three main classes of calculations: basic statistics, standardized principal components analysis, and Fourier analysis. Pronghorn habitat models based on the AVHRR measures correspond visually and statistically to GIS-based models produced using data that represent detailed knowledge of ground-condition.Measures of temporal dynamics also revealed statistically significant correlations with annual estimates of elk population in selected Arizona Game Management Units, suggesting elk respond to regional environmental changes that can be measured using satellite data. Such relationships, once verified and established, can be used to help indirectly monitor the population.Measures of landscape spatial structure derived from IKONOS high spatial resolution (1-m) satellite data using geostatistics effectively map details of Sonoran pronghorn antelope habitat. Local estimates of the nugget, sill, and range variogram parameters calculated within 25 x 25-meter image windows describe the spatial autocorrelation of the image, permitting classification of all pixels into coherent units whose signature graphs exhibit a classic variogram shape. The variogram parameters captured in these signatures have been shown in previous studies to discriminate between different species-specific vegetation associations.The synoptic view of the landscape provided by satellite data can inform resource management efforts. The ability to characterize the spatial structure and temporal dynamics of habitat using repeatable remote sensing data allows closer monitoring of the relationship between a species and its landscape.

Snap Your Fingers! An ERP/sLORETA Study Investigating Implicit Processing of Self- vs. Other-Related Movement Sounds Using the Passive Oddball Paradigm

PubMed Central

Justen, Christoph; Herbert, Cornelia

2016-01-01

So far, neurophysiological studies have investigated implicit and explicit self-related processing particularly for self-related stimuli such as the own face or name. The present study extends previous research to the implicit processing of self-related movement sounds and explores their spatio-temporal dynamics. Event-related potentials (ERPs) were assessed while participants (N = 12 healthy subjects) listened passively to previously recorded self- and other-related finger snapping sounds, presented either as deviants or standards during an oddball paradigm. Passive listening to low (500 Hz) and high (1000 Hz) pure tones served as additional control. For self- vs. other-related finger snapping sounds, analysis of ERPs revealed significant differences in the time windows of the N2a/MMN and P3. An subsequent source localization analysis with standardized low-resolution brain electromagnetic tomography (sLORETA) revealed increased cortical activation in distinct motor areas such as the supplementary motor area (SMA) in the N2a/mismatch negativity (MMN) as well as the P3 time window during processing of self- and other-related finger snapping sounds. In contrast, brain regions associated with self-related processing [e.g., right anterior/posterior cingulate cortex (ACC/PPC)] as well as the right inferior parietal lobule (IPL) showed increased activation particularly during processing of self- vs. other-related finger snapping sounds in the time windows of the N2a/MMN (ACC/PCC) or the P3 (IPL). None of these brain regions showed enhanced activation while listening passively to low (500 Hz) and high (1000 Hz) pure tones. Taken together, the current results indicate (1) a specific role of motor regions such as SMA during auditory processing of movement-related information, regardless of whether this information is self- or other-related, (2) activation of neural sources such as the ACC/PCC and the IPL during implicit processing of self-related movement stimuli, and (3) their differential temporal activation during deviance (N2a/MMN – ACC/PCC) and target detection (P3 – IPL) of self- vs. other-related movement sounds. PMID:27777557

77 FR 12588 - Long Fence & Home, LLLP; Analysis of Proposed Consent Order To Aid Public Comment

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-01

... homeowners can realize by replacing their windows, including the home's geographic location, size, insulation... window of a specific composition in a building having a specific level of insulation in a specific region..., energy savings, energy [[Page 12590

Chronobiology of Takotsubo Syndrome and Myocardial Infarction: Analogies and Differences.

PubMed

Manfredini, Roberto; Manfredini, Fabio; Fabbian, Fabio; Salmi, Raffaella; Gallerani, Massimo; Bossone, Eduardo; Deshmukh, Abhishek J

2016-10-01

Several pathophysiologic factors, not harmful if taken alone, are capable of triggering unfavorable events when presenting together within the same temporal window (chronorisk), and the occurrence of many cardiovascular events is not evenly distributed in time. Both acute myocardial infarction and takotsubo syndrome seem to exhibit a temporal preference in their onset, characterized by variations according to time of day, day of the week, and month of the year, although with both analogies and differences. Copyright © 2016 Elsevier Inc. All rights reserved.

Optimization of ecosystem model parameters with different temporal variabilities using tower flux data and an ensemble Kalman filter

NASA Astrophysics Data System (ADS)

He, L.; Chen, J. M.; Liu, J.; Mo, G.; Zhen, T.; Chen, B.; Wang, R.; Arain, M.

2013-12-01

Terrestrial ecosystem models have been widely used to simulate carbon, water and energy fluxes and climate-ecosystem interactions. In these models, some vegetation and soil parameters are determined based on limited studies from literatures without consideration of their seasonal variations. Data assimilation (DA) provides an effective way to optimize these parameters at different time scales . In this study, an ensemble Kalman filter (EnKF) is developed and applied to optimize two key parameters of an ecosystem model, namely the Boreal Ecosystem Productivity Simulator (BEPS): (1) the maximum photosynthetic carboxylation rate (Vcmax) at 25 °C, and (2) the soil water stress factor (fw) for stomatal conductance formulation. These parameters are optimized through assimilating observations of gross primary productivity (GPP) and latent heat (LE) fluxes measured in a 74 year-old pine forest, which is part of the Turkey Point Flux Station's age-sequence sites. Vcmax is related to leaf nitrogen concentration and varies slowly over the season and from year to year. In contrast, fw varies rapidly in response to soil moisture dynamics in the root-zone. Earlier studies suggested that DA of vegetation parameters at daily time steps leads to Vcmax values that are unrealistic. To overcome the problem, we developed a three-step scheme to optimize Vcmax and fw. First, the EnKF is applied daily to obtain precursor estimates of Vcmax and fw. Then Vcmax is optimized at different time scales assuming fw is unchanged from first step. The best temporal period or window size is then determined by analyzing the magnitude of the minimized cost-function, and the coefficient of determination (R2) and Root-mean-square deviation (RMSE) of GPP and LE between simulation and observation. Finally, the daily fw value is optimized for rain free days corresponding to the Vcmax curve from the best window size. The optimized fw is then used to model its relationship with soil moisture. We found that the optimized fw is best correlated linearly to soil water content at 5 to 10 cm depth. We also found that both the temporal scale or window size and the priori uncertainty of Vcmax (given as its standard deviation) are important in determining the seasonal trajectory of Vcmax. During the leaf expansion stage, an appropriate window size leads to reasonable estimate of Vcmax. In the summer, the fluctuation of optimized Vcmax is mainly caused by the uncertainties in Vcmax but not the window size. Our study suggests that a smooth Vcmax curve optimized from an optimal time window size is close to the reality though the RMSE of GPP at this window is not the minimum. It also suggests that for the accurate optimization of Vcmax, it is necessary to set appropriate levels of uncertainty of Vcmax in the spring and summer because the rate of leaf nitrogen concentration change is different over the season. Parameter optimizations for more sites and multi-years are in progress.

Changes in seasonal streamflow extremes experienced in rivers of Northwestern South America (Colombia)

NASA Astrophysics Data System (ADS)

Pierini, J. O.; Restrepo, J. C.; Aguirre, J.; Bustamante, A. M.; Velásquez, G. J.

2017-04-01

A measure of the variability in seasonal extreme streamflow was estimated for the Colombian Caribbean coast, using monthly time series of freshwater discharge from ten watersheds. The aim was to detect modifications in the streamflow monthly distribution, seasonal trends, variance and extreme monthly values. A 20-year length time moving window, with 1-year successive shiftments, was applied to the monthly series to analyze the seasonal variability of streamflow. The seasonal-windowed data were statistically fitted through the Gamma distribution function. Scale and shape parameters were computed using the Maximum Likelihood Estimation (MLE) and the bootstrap method for 1000 resample. A trend analysis was performed for each windowed-serie, allowing to detect the window of maximum absolute values for trends. Significant temporal shifts in seasonal streamflow distribution and quantiles (QT), were obtained for different frequencies. Wet and dry extremes periods increased significantly in the last decades. Such increase did not occur simultaneously through the region. Some locations exhibited continuous increases only at minimum QT.

Action-outcome learning and prediction shape the window of simultaneity of audiovisual outcomes.

PubMed

Desantis, Andrea; Haggard, Patrick

2016-08-01

To form a coherent representation of the objects around us, the brain must group the different sensory features composing these objects. Here, we investigated whether actions contribute in this grouping process. In particular, we assessed whether action-outcome learning and prediction contribute to audiovisual temporal binding. Participants were presented with two audiovisual pairs: one pair was triggered by a left action, and the other by a right action. In a later test phase, the audio and visual components of these pairs were presented at different onset times. Participants judged whether they were simultaneous or not. To assess the role of action-outcome prediction on audiovisual simultaneity, each action triggered either the same audiovisual pair as in the learning phase ('predicted' pair), or the pair that had previously been associated with the other action ('unpredicted' pair). We found the time window within which auditory and visual events appeared simultaneous increased for predicted compared to unpredicted pairs. However, no change in audiovisual simultaneity was observed when audiovisual pairs followed visual cues, rather than voluntary actions. This suggests that only action-outcome learning promotes temporal grouping of audio and visual effects. In a second experiment we observed that changes in audiovisual simultaneity do not only depend on our ability to predict what outcomes our actions generate, but also on learning the delay between the action and the multisensory outcome. When participants learned that the delay between action and audiovisual pair was variable, the window of audiovisual simultaneity for predicted pairs increased, relative to a fixed action-outcome pair delay. This suggests that participants learn action-based predictions of audiovisual outcome, and adapt their temporal perception of outcome events based on such predictions. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

Letter-sound processing deficits in children with developmental dyslexia: An ERP study.

PubMed

Moll, Kristina; Hasko, Sandra; Groth, Katharina; Bartling, Jürgen; Schulte-Körne, Gerd

2016-04-01

The time course during letter-sound processing was investigated in children with developmental dyslexia (DD) and typically developing (TD) children using electroencephalography. Thirty-eight children with DD and 25 TD children participated in a visual-auditory oddball paradigm. Event-related potentials (ERPs) elicited by standard and deviant stimuli in an early (100-190 ms) and late (560-750 ms) time window were analysed. In the early time window, ERPs elicited by the deviant stimulus were delayed and less left lateralized over fronto-temporal electrodes for children with DD compared to TD children. In the late time window, children with DD showed higher amplitudes extending more over right frontal electrodes. Longer latencies in the early time window and stronger right hemispheric activation in the late time window were associated with slower reading and naming speed. Additionally, stronger right hemispheric activation in the late time window correlated with poorer phonological awareness skills. Deficits in early stages of letter-sound processing influence later more explicit cognitive processes during letter-sound processing. Identifying the neurophysiological correlates of letter-sound processing and their relation to reading related skills provides insight into the degree of automaticity during letter-sound processing beyond behavioural measures of letter-sound-knowledge. Copyright © 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

A fast non-contact imaging photoplethysmography method using a tissue-like model

NASA Astrophysics Data System (ADS)

McDuff, Daniel J.; Blackford, Ethan B.; Estepp, Justin R.; Nishidate, Izumi

2018-02-01

Imaging photoplethysmography (iPPG) allows non-contact, concomitant measurement and visualization of peripheral blood flow using just an RGB camera. Most iPPG methods require a window of temporal data and complex computation, this makes real-time measurement and spatial visualization impossible. We present a fast,"window-less", non-contact imaging photoplethysmography method, based on a tissue-like model of the skin, that allows accurate measurement of heart rate and heart rate variability parameters. The error in heart rate estimates is equivalent to state-of-the-art techniques and computation is much faster.

Exploiting visual search theory to infer social interactions

NASA Astrophysics Data System (ADS)

Rota, Paolo; Dang-Nguyen, Duc-Tien; Conci, Nicola; Sebe, Nicu

2013-03-01

In this paper we propose a new method to infer human social interactions using typical techniques adopted in literature for visual search and information retrieval. The main piece of information we use to discriminate among different types of interactions is provided by proxemics cues acquired by a tracker, and used to distinguish between intentional and casual interactions. The proxemics information has been acquired through the analysis of two different metrics: on the one hand we observe the current distance between subjects, and on the other hand we measure the O-space synergy between subjects. The obtained values are taken at every time step over a temporal sliding window, and processed in the Discrete Fourier Transform (DFT) domain. The features are eventually merged into an unique array, and clustered using the K-means algorithm. The clusters are reorganized using a second larger temporal window into a Bag Of Words framework, so as to build the feature vector that will feed the SVM classifier.

Dynamic chirp control of all-optical format-converted pulsed data from a multi-wavelength inverse-optical-comb injected semiconductor optical amplifier.

PubMed

Lin, Gong-Ru; Pan, Ci-Ling; Yu, Kun-Chieh

2007-10-01

By spectrally and temporally reshaping the gain-window of a traveling-wave semiconductor optical amplifier (TWSOA) with a backward injected multi- or single-wavelength inverse-optical-comb, we theoretically and experimentally investigate the dynamic frequency chirp of the all-optical 10GBit/s Return-to-Zero (RZ) data-stream format-converted from the TWSOA under strong cross-gain depletion scheme. The multi-wavelength inverse-optical-comb injection effectively depletes the TWSOA gain spectrally and temporally, remaining a narrow gain-window and a reduced spectral linewidth and provide a converted RZ data with a smaller peak-to-peak frequency chirp of 6.7 GHz. Even at high inverse-optical-comb injection power and highly biased current condition for improving the operational bit-rate, the chirp of the multi-wavelength-injection converted RZ pulse is still 2.1-GHz smaller than that obtained by using single-wavelength injection at a cost of slight pulse-width broadening by 1 ps.

Detection of Temporally and Spatially Limited Periodic Earthquake Recurrence in Synthetic Seismic Records

NASA Astrophysics Data System (ADS)

Zielke, O.; Arrowsmith, R. J.

2005-12-01

The nonlinear dynamics of fault behavior are dominated by complex interactions among the multiple processes controlling the system. For example, temporal and spatial variations in pore pressure, healing effects, and stress transfer cause significant heterogeneities in fault properties and the stress-field at the sub-fault level. Numerical and laboratory fault models show that the interaction of large systems of fault elements causes the entire system to develop into a state of self-organized criticality. Once in this state, small perturbations of the system may result in chain reactions (i.e., earthquakes) which can affect any number of fault segments. This sensitivity to small perturbations is strong evidence for chaotic fault behavior, which implies that exact event prediction is not possible. However, earthquake prediction with a useful accuracy is nevertheless possible. Studies of other natural chaotic systems have shown that they may enter states of metastability, in which the system's behavior is predictable. Applying this concept to earthquake faults, these windows of metastable behavior should be characterized by periodic earthquake recurrence. The observed periodicity of the Parkfield, CA (M= 6) events may resemble such a window of metastability. I am statistically analyzing numerically generated seismic records to study these phases of periodic behavior. In this preliminary study, seismic records were generated using a model introduced by Nakanishi [Phys. Rev. A, 43, 6613-6621, 1991]. It consists of a one-dimensional chain of blocks (interconnected by springs) with a relaxation function that mimics velocity-weakened frictional behavior. The earthquakes occurring in this model show generally a power-law frequency-size distribution. However, for large events the distribution has a shoulder where the frequency of events is higher than expected from the power law. I have analyzed time-series of single block motions within the system. These time-series include noticeable periodicity during certain intervals in an otherwise aperiodic record. The observed periodic signal is not equally distributed over the range of offsets but shows a multi-modal distribution with increased periodicity for the smallest events and for large events that show a specific offset. These large events also form a shoulder in the frequency-size distribution. Apparently, the model exhibits characteristic earthquakes (defined by similar coseismic slip) that occur more frequently than expected from a power law distribution, and also are significantly more periodic. The wavelength of the periodic signal generally equals the minimum loading time, which is related to the loading velocity and the amount of coseismic slip (i.e., stress drop). No significant event occurs between the characteristic events as long as the system stays in a window of periodic behavior. Within the windows of periodic behavior, earthquake prediction is straightforward. Therefore, recognition of these windows not only in synthetic data but also in real seismic records, may improve the intra-window forecast of earthquakes. Further studies will attempt to determine the characteristics of onset, duration, and end of these windows of periodic earthquake recurrence. Only the motion of a single block within a bigger system was analyzed so far. Going from a zero dimensional scenario to a two dimensional case where the offsets not only of a single block but the displacement patterns caused by a certain event are analyzed will increase the verisimilitude of the detection of periodic earthquake recurrence within an otherwise chaotic seismic record.

Applicability of optical scanner method for fine root dynamics

NASA Astrophysics Data System (ADS)

Kume, Tomonori; Ohashi, Mizue; Makita, Naoki; Khoon Kho, Lip; Katayama, Ayumi; Matsumoto, Kazuho; Ikeno, Hidetoshi

2016-04-01

Fine root dynamics is one of the important components in forest carbon cycling, as ~60 % of tree photosynthetic production can be allocated to root growth and metabolic activities. Various techniques have been developed for monitoring fine root biomass, production, mortality in order to understand carbon pools and fluxes resulting from fine roots dynamics. The minirhizotron method is now a widely used technique, in which a transparent tube is inserted into the soil and researchers count an increase and decrease of roots along the tube using images taken by a minirhizotron camera or minirhizotron video camera inside the tube. This method allows us to observe root behavior directly without destruction, but has several weaknesses; e.g., the difficulty of scaling up the results to stand level because of the small observation windows. Also, most of the image analysis are performed manually, which may yield insufficient quantitative and objective data. Recently, scanner method has been proposed, which can produce much bigger-size images (A4-size) with lower cost than those of the minirhizotron methods. However, laborious and time-consuming image analysis still limits the applicability of this method. In this study, therefore, we aimed to develop a new protocol for scanner image analysis to extract root behavior in soil. We evaluated applicability of this method in two ways; 1) the impact of different observers including root-study professionals, semi- and non-professionals on the detected results of root dynamics such as abundance, growth, and decomposition, and 2) the impact of window size on the results using a random sampling basis exercise. We applied our new protocol to analyze temporal changes of root behavior from sequential scanner images derived from a Bornean tropical forests. The results detected by the six observers showed considerable concordance in temporal changes in the abundance and the growth of fine roots but less in the decomposition. We also examined potential errors due to window size in the temporal changes in abundance and growth using the detected results, suggesting high applicability of the scanner methods with wide observation windows.

24 CFR 200.955 - Supplementary specific requirements under the HUD building product standard and certification...

Code of Federal Regulations, 2010 CFR

2010-04-01

... under the HUD building product standard and certification program for fenestration products (windows and... fenestration products (windows and doors). (a) Applicable standards. (1) All windows and doors shall be... Windows and Glass Doors. (2) This standard has been approved by the Director of the Federal Register for...

47 CFR 15.323 - Specific requirements for devices operating in the 1920-1930 MHz sub-band.

Code of Federal Regulations, 2010 CFR

2010-10-01

...] (c) Devices must incorporate a mechanism for monitoring the time and spectrum windows that its... transmission, devices must monitor the combined time and spectrum windows in which they intend to transmit for... windows without further monitoring. However, occupation of the same combined time and spectrum windows by...

Maternal pesticide use and birth weight in the agricultural health study.

PubMed

Sathyanarayana, Sheela; Basso, Olga; Karr, Catherine J; Lozano, Paula; Alavanja, Michael; Sandler, Dale P; Hoppin, Jane A

2010-04-01

Studies examining the association between maternal pesticide exposure and low birth weight yield conflicting results. The authors examined the association between maternal pesticide use and birth weight among women in the Agricultural Health Study, a large study of pesticide applicators and their spouses in Iowa and North Carolina. The authors evaluated self-reported pesticide use of 27 individual pesticides in relation to birth weight among 2246 farm women whose most recent singleton birth occurred within 5 years of enrollment (1993-1997). The authors used linear regression models adjusted for site, preterm birth, medical parity, maternal body mass index, height, and smoking. The results showed that mean infant birth weight was 3586 g (+/- 546 g), and 3% of the infants were low birth weight (<2500 g). First-trimester pesticide-related tasks were not associated with birth weight. Ever use of the pesticide carbaryl was associated with decreased birth weight (-82 g, 95% confidence interval [CI] = -132, -31). This study thus provides limited evidence about pesticide use as a modulator of birth weight. Overall, the authors observed no associations between birth weight and pesticide-related activities during early pregnancy; however, the authors have no data on temporal specificity of individual pesticide exposures prior to or during pregnancy and therefore cannot draw conclusions related to these exposure windows. Given the widespread exposure to pesticide products, additional evaluation of maternal pregnancy exposures at specific time windows and subsequent birth outcomes is warranted.

Assessment of cardiac time intervals using high temporal resolution real-time spiral phase contrast with UNFOLDed-SENSE.

PubMed

Kowalik, Grzegorz T; Knight, Daniel S; Steeden, Jennifer A; Tann, Oliver; Odille, Freddy; Atkinson, David; Taylor, Andrew; Muthurangu, Vivek

2015-02-01

To develop a real-time phase contrast MR sequence with high enough temporal resolution to assess cardiac time intervals. The sequence utilized spiral trajectories with an acquisition strategy that allowed a combination of temporal encoding (Unaliasing by fourier-encoding the overlaps using the temporal dimension; UNFOLD) and parallel imaging (Sensitivity encoding; SENSE) to be used (UNFOLDed-SENSE). An in silico experiment was performed to determine the optimum UNFOLD filter. In vitro experiments were carried out to validate the accuracy of time intervals calculation and peak mean velocity quantification. In addition, 15 healthy volunteers were imaged with the new sequence, and cardiac time intervals were compared to reference standard Doppler echocardiography measures. For comparison, in silico, in vitro, and in vivo experiments were also carried out using sliding window reconstructions. The in vitro experiments demonstrated good agreement between real-time spiral UNFOLDed-SENSE phase contrast MR and the reference standard measurements of velocity and time intervals. The protocol was successfully performed in all volunteers. Subsequent measurement of time intervals produced values in keeping with literature values and good agreement with the gold standard echocardiography. Importantly, the proposed UNFOLDed-SENSE sequence outperformed the sliding window reconstructions. Cardiac time intervals can be successfully assessed with UNFOLDed-SENSE real-time spiral phase contrast. Real-time MR assessment of cardiac time intervals may be beneficial in assessment of patients with cardiac conditions such as diastolic dysfunction. © 2014 Wiley Periodicals, Inc.

High-dynamic-range cross-correlator for shot-to-shot measurement of temporal contrast

NASA Astrophysics Data System (ADS)

Kon, Akira; Nishiuchi, Mamiko; Kiriyama, Hiromitsu; Ogura, Koichi; Mori, Michiaki; Sakaki, Hironao; Kando, Masaki; Kondo, Kiminori

2017-01-01

The temporal contrast of an ultrahigh-intensity laser is a crucial parameter for laser plasma experiments. We have developed a multichannel cross-correlator (MCCC) for single-shot measurements of the temporal contrast in a high-power laser system. The MCCC is based on third-order cross-correlation, and has four channels and independent optical delay lines. We have experimentally demonstrated that the MCCC system achieves a high dynamic range of ˜1012 and a large temporal window of ˜1 ns. Moreover, we were able to measure the shot-to-shot fluctuations of a short-prepulse intensity at -26 ps and long-pulse (amplified spontaneous emission, ASE) intensities at -30, -450, and -950 ps before the arrival of the main pulse at the interaction point.

Coverage centralities for temporal networks*

NASA Astrophysics Data System (ADS)

Takaguchi, Taro; Yano, Yosuke; Yoshida, Yuichi

2016-02-01

Structure of real networked systems, such as social relationship, can be modeled as temporal networks in which each edge appears only at the prescribed time. Understanding the structure of temporal networks requires quantifying the importance of a temporal vertex, which is a pair of vertex index and time. In this paper, we define two centrality measures of a temporal vertex based on the fastest temporal paths which use the temporal vertex. The definition is free from parameters and robust against the change in time scale on which we focus. In addition, we can efficiently compute these centrality values for all temporal vertices. Using the two centrality measures, we reveal that distributions of these centrality values of real-world temporal networks are heterogeneous. For various datasets, we also demonstrate that a majority of the highly central temporal vertices are located within a narrow time window around a particular time. In other words, there is a bottleneck time at which most information sent in the temporal network passes through a small number of temporal vertices, which suggests an important role of these temporal vertices in spreading phenomena. Contribution to the Topical Issue "Temporal Network Theory and Applications", edited by Petter Holme.Supplementary material in the form of one pdf file available from the Journal web page at http://dx.doi.org/10.1140/epjb/e2016-60498-7

Velocity landscape correlation resolves multiple flowing protein populations from fluorescence image time series.

PubMed

Pandžić, Elvis; Abu-Arish, Asmahan; Whan, Renee M; Hanrahan, John W; Wiseman, Paul W

2018-02-16

Molecular, vesicular and organellar flows are of fundamental importance for the delivery of nutrients and essential components used in cellular functions such as motility and division. With recent advances in fluorescence/super-resolution microscopy modalities we can resolve the movements of these objects at higher spatio-temporal resolutions and with better sensitivity. Previously, spatio-temporal image correlation spectroscopy has been applied to map molecular flows by correlation analysis of fluorescence fluctuations in image series. However, an underlying assumption of this approach is that the sampled time windows contain one dominant flowing component. Although this was true for most of the cases analyzed earlier, in some situations two or more different flowing populations can be present in the same spatio-temporal window. We introduce an approach, termed velocity landscape correlation (VLC), which detects and extracts multiple flow components present in a sampled image region via an extension of the correlation analysis of fluorescence intensity fluctuations. First we demonstrate theoretically how this approach works, test the performance of the method with a range of computer simulated image series with varying flow dynamics. Finally we apply VLC to study variable fluxing of STIM1 proteins on microtubules connected to the plasma membrane of Cystic Fibrosis Bronchial Epithelial (CFBE) cells. Copyright © 2018 Elsevier Inc. All rights reserved.

Measurement of cochlear length using the 'A' value for cochlea basal diameter: A feasibility study.

PubMed

Deep, Nicholas L; Howard, Brittany E; Holbert, Sarah O; Hoxworth, Joseph M; Barrs, David M

2017-07-01

To determine whether the cochlea basal diameter (A value) measurement can be consistently and precisely obtained from high-resolution temporal bone imaging for use in cochlear length estimation. A feasibility study at a tertiary referral center was performed using the temporal bone CTs of 40 consecutive patients. The distance from the round window to the lateral wall was measured for each cochlea by two independent reviewers, a neuroradiologist and an otolaryngologist. The interrater reliability was calculated using the intraclass correlation coefficient (ICC) and the Bland-Altman plot. Forty patients (19 males, 21 females) for a total of 80 cochleae were included. Interrater reliability on the same ear had a high level of agreement by both the ICC and the Bland-Altman plot. ICCs were 0.90 (95% CI: 0.82, 0.94) for the left ear and 0.96 (95% CI: 0.92, 0.98) for the right ear. Bland-Altman plot confirmed interrater reliability with all 96% of measurements falling within the 95% limits of agreement. Measurement between the round window and lateral cochlear wall can be consistently and reliably obtained from high-resolution temporal bone CT scans. Thus, it is feasible to utilize this method to estimate the cochlear length of patients undergoing cochlear implantation.

Computing an optimal time window of audiovisual integration in focused attention tasks: illustrated by studies on effect of age and prior knowledge.

PubMed

Colonius, Hans; Diederich, Adele

2011-07-01

The concept of a "time window of integration" holds that information from different sensory modalities must not be perceived too far apart in time in order to be integrated into a multisensory perceptual event. Empirical estimates of window width differ widely, however, ranging from 40 to 600 ms depending on context and experimental paradigm. Searching for theoretical derivation of window width, Colonius and Diederich (Front Integr Neurosci 2010) developed a decision-theoretic framework using a decision rule that is based on the prior probability of a common source, the likelihood of temporal disparities between the unimodal signals, and the payoff for making right or wrong decisions. Here, this framework is extended to the focused attention task where subjects are asked to respond to signals from a target modality only. Evoking the framework of the time-window-of-integration (TWIN) model, an explicit expression for optimal window width is obtained. The approach is probed on two published focused attention studies. The first is a saccadic reaction time study assessing the efficiency with which multisensory integration varies as a function of aging. Although the window widths for young and older adults differ by nearly 200 ms, presumably due to their different peripheral processing speeds, neither of them deviates significantly from the optimal values. In the second study, head saccadic reactions times to a perfectly aligned audiovisual stimulus pair had been shown to depend on the prior probability of spatial alignment. Intriguingly, they reflected the magnitude of the time-window widths predicted by our decision-theoretic framework, i.e., a larger time window is associated with a higher prior probability.

Slow Temporal Integration Enables Robust Neural Coding and Perception of a Cue to Sound Source Location.

PubMed

Brown, Andrew D; Tollin, Daniel J

2016-09-21

In mammals, localization of sound sources in azimuth depends on sensitivity to interaural differences in sound timing (ITD) and level (ILD). Paradoxically, while typical ILD-sensitive neurons of the auditory brainstem require millisecond synchrony of excitatory and inhibitory inputs for the encoding of ILDs, human and animal behavioral ILD sensitivity is robust to temporal stimulus degradations (e.g., interaural decorrelation due to reverberation), or, in humans, bilateral clinical device processing. Here we demonstrate that behavioral ILD sensitivity is only modestly degraded with even complete decorrelation of left- and right-ear signals, suggesting the existence of a highly integrative ILD-coding mechanism. Correspondingly, we find that a majority of auditory midbrain neurons in the central nucleus of the inferior colliculus (of chinchilla) effectively encode ILDs despite complete decorrelation of left- and right-ear signals. We show that such responses can be accounted for by relatively long windows of bilateral excitatory-inhibitory interaction, which we explicitly measure using trains of narrowband clicks. Neural and behavioral data are compared with the outputs of a simple model of ILD processing with a single free parameter, the duration of excitatory-inhibitory interaction. Behavioral, neural, and modeling data collectively suggest that ILD sensitivity depends on binaural integration of excitation and inhibition within a ≳3 ms temporal window, significantly longer than observed in lower brainstem neurons. This relatively slow integration potentiates a unique role for the ILD system in spatial hearing that may be of particular importance when informative ITD cues are unavailable. In mammalian hearing, interaural differences in the timing (ITD) and level (ILD) of impinging sounds carry critical information about source location. However, natural sounds are often decorrelated between the ears by reverberation and background noise, degrading the fidelity of both ITD and ILD cues. Here we demonstrate that behavioral ILD sensitivity (in humans) and neural ILD sensitivity (in single neurons of the chinchilla auditory midbrain) remain robust under stimulus conditions that render ITD cues undetectable. This result can be explained by "slow" temporal integration arising from several-millisecond-long windows of excitatory-inhibitory interaction evident in midbrain, but not brainstem, neurons. Such integrative coding can account for the preservation of ILD sensitivity despite even extreme temporal degradations in ecological acoustic stimuli. Copyright © 2016 the authors 0270-6474/16/369908-14$15.00/0.

The ultrasound brain helmet: early human feasibility study of multiple simultaneous 3D scans of cerebral vasculature

NASA Astrophysics Data System (ADS)

Lindsey, Brooks D.; Ivancevich, Nikolas M.; Whitman, John; Light, Edward; Fronheiser, Matthew; Nicoletto, Heather A.; Laskowitz, Daniel T.; Smith, Stephen W.

2009-02-01

We describe early stage experiments to test the feasibility of an ultrasound brain helmet to produce multiple simultaneous real-time 3D scans of the cerebral vasculature from temporal and suboccipital acoustic windows of the skull. The transducer hardware and software of the Volumetrics Medical Imaging real-time 3D scanner were modified to support dual 2.5 MHz matrix arrays of 256 transmit elements and 128 receive elements which produce two simultaneous 64° pyramidal scans. The real-time display format consists of two coronal B-mode images merged into a 128° sector, two simultaneous parasagittal images merged into a 128° × 64° C-mode plane, and a simultaneous 64° axial image. Real-time 3D color Doppler images acquired in initial clinical studies after contrast injection demonstrate flow in several representative blood vessels. An offline Doppler rendering of data from two transducers simultaneously scanning via the temporal windows provides an early visualization of the flow in vessels on both sides of the brain. The long-term goal is to produce real-time 3D ultrasound images of the cerebral vasculature from a portable unit capable of internet transmission, thus enabling interactive 3D imaging, remote diagnosis and earlier therapeutic intervention. We are motivated by the urgency for rapid diagnosis of stroke due to the short time window of effective therapeutic intervention.

[Applied anatomy of facial recess and posterior tympanum related to cochlear implantation].

PubMed

Zou, Tuanming; Xie, Nanping; Guo, Menghe; Shu, Fan; Zhang, Hongzheng

2012-05-01

To investigate the related parameters of temporal bone structure in the surgery of cochlear implantation through facial recess approach so as to offer a theoretical reference for the avoidance of facial nerve injury and the accurate localization. In a surgical simulation experiment, twenty human temporal bones were studied. The correlation parameters were measured under surgical microscope. Distance between suprameatal spine and short process of incus was (12.44 +/- 0.51) mm. Width from crotch of chorda tympani nerve to stylomastoid foramen was (2.67 +/- 0.51) mm. Distance between short process of incus and crotch of chorda tympani nerve was (15.22 +/- 0.83) mm. The location of maximal width of the facial recess into short process of incus, crotch of chorda tympani nerve were (6.28 +/- 0.41) mm, (9.81 +/- 0.71) mm, respectively. The maximal width of the facial recess was (2.73 +/- 0.20) mm. The value at level of stapes and round window were (2.48 +/- 0.20 mm) and (2.24 +/- 0.18) mm, respectively. Distance between pyramidalis eminence and anterior round window was (2.22 +/- 0.21) mm. Width from stapes to underneath round window was (2.16 +/- 0.14) mm. These parameters provide a reference value to determine the position of cochlear inserting the electrode array into the scale tympani and opening facial recess firstly to avoid potential damage to facial nerve in surgery.

Differential Intracochlear Sound Pressure Measurements in Normal Human Temporal Bones

NASA Astrophysics Data System (ADS)

Nakajima, Hideko Heidi; Dong, Wei; Olson, Elizabeth S.; Merchant, Saumil N.; Ravicz, Michael E.; Rosowski, John J.

2009-02-01

We present the first simultaneous sound pressure measurements in scala vestibuli and scala tympani of the cochlea in human cadaveric temporal bones. Micro-scale fiberoptic pressure sensors enabled the study of differential sound pressure at the cochlear base. This differential pressure is the input to the cochlear partition, driving cochlear waves and auditory transduction. Results showed that: pressure of scala vestibuli was much greater than scala tympani except at low and high frequencies where scala tympani pressure affects the input to the cochlea; the differential pressure proved to be an excellent measure of normal ossicular transduction of sound (shown to decrease 30-50 dB with ossicular disarticulation, whereas the individual scala pressures were significantly affected by non-ossicular conduction of sound at high frequencies); the middle-ear gain and differential pressure were generally bandpass in frequency dependence; and the middle-ear delay in the human was over twice that of the gerbil. Concurrent stapes velocity measurements allowed determination of the differential impedance across the partition and round-window impedance. The differential impedance was generally resistive, while the round-window impedance was consistent with a compliance in conjunction with distributed inertia and damping. Our techniques can be used to study inner-ear conductive pathologies (e.g., semicircular dehiscence), as well as non-ossicular cochlear stimulation (e.g., round-window stimulation) - situations that cannot be completely quantified by measurements of stapes velocity or scala-vestibuli pressure by themselves.

Non ictal onset zone: A window to ictal dynamics.

PubMed

Afra, Pegah; Hanrahan, Sara J; Kellis, Spencer Sterling; House, Paul

2017-01-01

The focal and network concepts of epilepsy present different aspects of electroclinical phenomenon of seizures. Here, we present a 23-year-old man undergoing surgical evaluation with left fronto-temporal electrocorticography (ECoG) and microelectrode-array (MEA) in the middle temporal gyrus (MTG). We compare action-potential (AP) and local field potentials (LFP) recorded from MEA with ECoG. Seizure onset in the mesial-temporal lobe was characterized by changes in the pattern of AP-firing without clear changes in LFP or ECoG in MTG. This suggests simultaneous analysis of neuronal activity in differing spatial scales and frequency ranges provide complementary insights into how focal and network neurophysiological activity contribute to ictal activity.

Neuronal synchronization and selective color processing in the human brain.

PubMed

Müller, Matthias M; Keil, Andreas

2004-04-01

In the present study, subjects selectively attended to the color of checkerboards in a feature-based attention paradigm. Induced gamma band responses (GBRs), the induced alpha band, and the event-related potential (ERP) were analyzed to uncover neuronal dynamics during selective feature processing. Replicating previous ERP findings, the selection negativity (SN) with a latency of about 160 msec was extracted. Furthermore, and similarly to previous EEG studies, a gamma band peak in a time window between 290 and 380 msec was found. This peak had its major energy in the 55- to 70-Hz range and was significantly larger for the attended color. Contrary to previous human induced gamma band studies, a much earlier 40- to 50-Hz peak in a time window between 160 and 220 msec after stimulus onset and, thus, concurrently to the SN was prominent with significantly more energy for attended as opposed to unattended color. The induced alpha band (9.8-11.7 Hz), on the other hand, exhibited a marked suppression for attended color in a time window between 450 and 600 msec after stimulus onset. A comparison of the time course of the 40- to 50-Hz and 55- to 70-Hz induced GBR, the induced alpha band, and the ERP revealed temporal coincidences for changes in the morphology of these brain responses. Despite these similarities in the time domain, the cortical source configuration was found to discriminate between induced GBRs and the SN. Our results suggest that large-scale synchronous high-frequency brain activity as measured in the human GBR play a specific role in attentive processing of stimulus features.

Research on spatio-temporal database techniques for spatial information service

NASA Astrophysics Data System (ADS)

Zhao, Rong; Wang, Liang; Li, Yuxiang; Fan, Rongshuang; Liu, Ping; Li, Qingyuan

2007-06-01

Geographic data should be described by spatial, temporal and attribute components, but the spatio-temporal queries are difficult to be answered within current GIS. This paper describes research into the development and application of spatio-temporal data management system based upon GeoWindows GIS software platform which was developed by Chinese Academy of Surveying and Mapping (CASM). Faced the current and practical requirements of spatial information application, and based on existing GIS platform, one kind of spatio-temporal data model which integrates vector and grid data together was established firstly. Secondly, we solved out the key technique of building temporal data topology, successfully developed a suit of spatio-temporal database management system adopting object-oriented methods. The system provides the temporal data collection, data storage, data management and data display and query functions. Finally, as a case study, we explored the application of spatio-temporal data management system with the administrative region data of multi-history periods of China as the basic data. With all the efforts above, the GIS capacity of management and manipulation in aspect of time and attribute of GIS has been enhanced, and technical reference has been provided for the further development of temporal geographic information system (TGIS).

Time-gated detection of protein-protein interactions with transcriptional readout

PubMed Central

Sanchez, Mateo I; Coukos, Robert; von Zastrow, Mark

2017-01-01

Transcriptional assays, such as yeast two-hybrid and TANGO, that convert transient protein-protein interactions (PPIs) into stable expression of transgenes are powerful tools for PPI discovery, screens, and analysis of cell populations. However, such assays often have high background and lose information about PPI dynamics. We have developed SPARK (Specific Protein Association tool giving transcriptional Readout with rapid Kinetics), in which proteolytic release of a membrane-tethered transcription factor (TF) requires both a PPI to deliver a protease proximal to its cleavage peptide and blue light to uncage the cleavage site. SPARK was used to detect 12 different PPIs in mammalian cells, with 5 min temporal resolution and signal ratios up to 37. By shifting the light window, we could reconstruct PPI time-courses. Combined with FACS, SPARK enabled 51 fold enrichment of PPI-positive over PPI-negative cells. Due to its high specificity and sensitivity, SPARK has the potential to advance PPI analysis and discovery. PMID:29189201

Fluctuation scaling of quotation activities in the foreign exchange market

NASA Astrophysics Data System (ADS)

Sato, Aki-Hiro; Nishimura, Maiko; Hołyst, Janusz A.

2010-07-01

We study the scaling behavior of quotation activities for various currency pairs in the foreign exchange market. The components’ centrality is estimated from multiple time series and visualized as a currency pair network. The power-law relationship between a mean of quotation activity and its standard deviation for each currency pair is found. The scaling exponent α and the ratio between common and specific fluctuations η increase with the length of the observation time window Δt. The result means that although for Δt=1 (min), the market dynamics are governed by specific processes, and at a longer time scale Δt>100 (min) the common information flow becomes more important. We point out that quotation activities are not independently Poissonian for Δt=1 (min), and temporally or mutually correlated activities of quotations can happen even at this time scale. A stochastic model for the foreign exchange market based on a bipartite graph representation is proposed.

Dynamic CRM occupancy reflects a temporal map of developmental progression.

PubMed

Wilczyński, Bartek; Furlong, Eileen E M

2010-06-22

Development is driven by tightly coordinated spatio-temporal patterns of gene expression, which are initiated through the action of transcription factors (TFs) binding to cis-regulatory modules (CRMs). Although many studies have investigated how spatial patterns arise, precise temporal control of gene expression is less well understood. Here, we show that dynamic changes in the timing of CRM occupancy is a prevalent feature common to all TFs examined in a developmental ChIP time course to date. CRMs exhibit complex binding patterns that cannot be explained by the sequence motifs or expression of the TFs themselves. The temporal changes in TF binding are highly correlated with dynamic patterns of target gene expression, which in turn reflect transitions in cellular function during different stages of development. Thus, it is not only the timing of a TF's expression, but also its temporal occupancy in refined time windows, which determines temporal gene expression. Systematic measurement of dynamic CRM occupancy may therefore serve as a powerful method to decode dynamic changes in gene expression driving developmental progression.

Ultrafast chirped optical waveform recorder using a time microscope

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bennett, Corey Vincent

2015-04-21

A new technique for capturing both the amplitude and phase of an optical waveform is presented. This technique can capture signals with many THz of bandwidths in a single shot (e.g., temporal resolution of about 44 fs), or be operated repetitively at a high rate. That is, each temporal window (or frame) is captured single shot, in real time, but the process may be run repeatedly or single-shot. By also including a variety of possible demultiplexing techniques, this process is scalable to recoding continuous signals.

Can the black box be cracked? The augmentation of microbial ecology by high-resolution, automated sensing technologies.

PubMed

Shade, Ashley; Carey, Cayelan C; Kara, Emily; Bertilsson, Stefan; McMahon, Katherine D; Smith, Matthew C

2009-08-01

Automated sensing technologies, 'ASTs,' are tools that can monitor environmental or microbial-related variables at increasingly high temporal resolution. Microbial ecologists are poised to use AST data to couple microbial structure, function and associated environmental observations on temporal scales pertinent to microbial processes. In the context of aquatic microbiology, we discuss three applications of ASTs: windows on the microbial world, adaptive sampling and adaptive management. We challenge microbial ecologists to push AST potential in helping to reveal relationships between microbial structure and function.

16 CFR 1201.40 - Interpretation concerning bathtub and shower doors and enclosures.

Code of Federal Regulations, 2010 CFR

2010-01-01

... materials in a window that is located over a bathtub or within a shower stall and in the exterior wall of a...” contain no specific exemption for glazing materials in such windows. If read literally, the Standard could include glazing materials in an exterior wall window located above a bathtub because that window could be...

Climatic influences on the breeding biology of the agile frog ( Rana dalmatina)

NASA Astrophysics Data System (ADS)

Combes, Magali; Pinaud, David; Barbraud, Christophe; Trotignon, Jacques; Brischoux, François

2018-02-01

Severe population declines of amphibians have been shown to be attributed to climate change. Nevertheless, the various mechanisms through which climate can influence population dynamics of amphibians remain to be assessed, notably to disentangle the relative synergetic or antagonistic influences of temperature and precipitations on specific life history stages. We investigated the impact of rainfall and temperature on the egg-clutch abundance in a population of agile frog ( Rana dalmatina) during 29 years (1987-2016) on 14 breeding sites located in Brenne Natural Park, France. Specifically, we examined the influence of environmental conditions occurring during five temporal windows of the year cycle corresponding to specific life history stages. Overall, our results suggest that the year-to-year fluctuations of egg-clutch abundances in Brenne Natural Park were partly dependent on local climatic conditions (rainfall and temperature). Climate seemed to influence breeding frogs during the autumn-winter period preceding reproduction. Spring and summer conditions did not influence reproduction. Additionally, we failed to detect effects of climatic conditions on newly metamorphosed individuals. Other factors such as density dependence and inter-specific interactions with introduced predators are likely to play a significant role in reproduction dynamics of the studied frog populations.

Climatic influences on the breeding biology of the agile frog (Rana dalmatina).

PubMed

Combes, Magali; Pinaud, David; Barbraud, Christophe; Trotignon, Jacques; Brischoux, François

2017-12-19

Severe population declines of amphibians have been shown to be attributed to climate change. Nevertheless, the various mechanisms through which climate can influence population dynamics of amphibians remain to be assessed, notably to disentangle the relative synergetic or antagonistic influences of temperature and precipitations on specific life history stages. We investigated the impact of rainfall and temperature on the egg-clutch abundance in a population of agile frog (Rana dalmatina) during 29 years (1987-2016) on 14 breeding sites located in Brenne Natural Park, France. Specifically, we examined the influence of environmental conditions occurring during five temporal windows of the year cycle corresponding to specific life history stages. Overall, our results suggest that the year-to-year fluctuations of egg-clutch abundances in Brenne Natural Park were partly dependent on local climatic conditions (rainfall and temperature). Climate seemed to influence breeding frogs during the autumn-winter period preceding reproduction. Spring and summer conditions did not influence reproduction. Additionally, we failed to detect effects of climatic conditions on newly metamorphosed individuals. Other factors such as density dependence and inter-specific interactions with introduced predators are likely to play a significant role in reproduction dynamics of the studied frog populations.

Geology and geochemistry of volcanic centers within the eastern half of the Sonoma volcanic field, northern San Francisco Bay region, California

USGS Publications Warehouse

Sweetkind, Donald S.; Rytuba, James J.; Langenheim, V.E.; Fleck, Robert J.

2011-01-01

The volcanic fields in the California Coast Ranges north of San Francisco Bay are temporally and spatially associated with the northward migration of the Mendocino triple junction and the transition from subduction and associated arc volcanism to a slab window tectonic environment. Our geochemical analyses from the Sonoma volcanic field highlight the geochemical diversity of these volcanic rocks, allowing us to clearly distinguish these volcanic rocks from those of the roughly coeval ancestral Cascades magmatic arc to the west, and also to compare rocks of the Sonoma volcanic field to rocks from other slab window settings.

Attosecond light sources in the water window

NASA Astrophysics Data System (ADS)

Ren, Xiaoming; Li, Jie; Yin, Yanchun; Zhao, Kun; Chew, Andrew; Wang, Yang; Hu, Shuyuan; Cheng, Yan; Cunningham, Eric; Wu, Yi; Chini, Michael; Chang, Zenghu

2018-02-01

As a compact and burgeoning alternative to synchrotron radiation and free-electron lasers, high harmonic generation (HHG) has proven its superiority in static and time-resolved extreme ultraviolet spectroscopy for the past two decades and has recently gained many interests and successes in generating soft x-ray emissions covering the biologically important water window spectral region. Unlike synchrotron and free-electron sources, which suffer from relatively long pulse width or large time jitter, soft x-ray sources from HHG could offer attosecond time resolution and be synchronized with their driving field to investigate time-resolved near edge absorption spectroscopy, which could reveal rich structural and dynamical information of the interrogated samples. In this paper, we review recent progresses on generating and characterizing attosecond light sources in the water window region. We show our development of an energetic, two-cycle, carrier-envelope phase stable laser source at 1.7 μm and our achievement in producing a 53 as soft x-ray pulse covering the carbon K-edge in the water window. Such source paves the ways for the next generation x-ray spectroscopy with unprecedented temporal resolution.

Window-Based Channel Impulse Response Prediction for Time-Varying Ultra-Wideband Channels.

PubMed

Al-Samman, A M; Azmi, M H; Rahman, T A; Khan, I; Hindia, M N; Fattouh, A

2016-01-01

This work proposes channel impulse response (CIR) prediction for time-varying ultra-wideband (UWB) channels by exploiting the fast movement of channel taps within delay bins. Considering the sparsity of UWB channels, we introduce a window-based CIR (WB-CIR) to approximate the high temporal resolutions of UWB channels. A recursive least square (RLS) algorithm is adopted to predict the time evolution of the WB-CIR. For predicting the future WB-CIR tap of window wk, three RLS filter coefficients are computed from the observed WB-CIRs of the left wk-1, the current wk and the right wk+1 windows. The filter coefficient with the lowest RLS error is used to predict the future WB-CIR tap. To evaluate our proposed prediction method, UWB CIRs are collected through measurement campaigns in outdoor environments considering line-of-sight (LOS) and non-line-of-sight (NLOS) scenarios. Under similar computational complexity, our proposed method provides an improvement in prediction errors of approximately 80% for LOS and 63% for NLOS scenarios compared with a conventional method.

Window-Based Channel Impulse Response Prediction for Time-Varying Ultra-Wideband Channels

PubMed Central

Al-Samman, A. M.; Azmi, M. H.; Rahman, T. A.; Khan, I.; Hindia, M. N.; Fattouh, A.

2016-01-01

This work proposes channel impulse response (CIR) prediction for time-varying ultra-wideband (UWB) channels by exploiting the fast movement of channel taps within delay bins. Considering the sparsity of UWB channels, we introduce a window-based CIR (WB-CIR) to approximate the high temporal resolutions of UWB channels. A recursive least square (RLS) algorithm is adopted to predict the time evolution of the WB-CIR. For predicting the future WB-CIR tap of window wk, three RLS filter coefficients are computed from the observed WB-CIRs of the left wk−1, the current wk and the right wk+1 windows. The filter coefficient with the lowest RLS error is used to predict the future WB-CIR tap. To evaluate our proposed prediction method, UWB CIRs are collected through measurement campaigns in outdoor environments considering line-of-sight (LOS) and non-line-of-sight (NLOS) scenarios. Under similar computational complexity, our proposed method provides an improvement in prediction errors of approximately 80% for LOS and 63% for NLOS scenarios compared with a conventional method. PMID:27992445

Evaluating the effect of aging on interference resolution with time-varying complex networks analysis

PubMed Central

Ariza, Pedro; Solesio-Jofre, Elena; Martínez, Johann H.; Pineda-Pardo, José A.; Niso, Guiomar; Maestú, Fernando; Buldú, Javier M.

2015-01-01

In this study we used graph theory analysis to investigate age-related reorganization of functional networks during the active maintenance of information that is interrupted by external interference. Additionally, we sought to investigate network differences before and after averaging network parameters between both maintenance and interference windows. We compared young and older adults by measuring their magnetoencephalographic recordings during an interference-based working memory task restricted to successful recognitions. Data analysis focused on the topology/temporal evolution of functional networks during both the maintenance and interference windows. We observed that: (a) Older adults require higher synchronization between cortical brain sites in order to achieve a successful recognition, (b) The main differences between age groups arise during the interference window, (c) Older adults show reduced ability to reorganize network topology when interference is introduced, and (d) Averaging network parameters leads to a loss of sensitivity to detect age differences. PMID:26029079

Replacement Sequence of Events Generator

NASA Technical Reports Server (NTRS)

Fisher, Forest; Gladden, Daniel Wenkert Roy; Khanampompan, Teerpat

2008-01-01

The soeWINDOW program automates the generation of an ITAR (International Traffic in Arms Regulations)-compliant sub-RSOE (Replacement Sequence of Events) by extracting a specified temporal window from an RSOE while maintaining page header information. RSOEs contain a significant amount of information that is not ITAR-compliant, yet that foreign partners need to see for command details to their instrument, as well as the surrounding commands that provide context for validation. soeWINDOW can serve as an example of how command support products can be made ITAR-compliant for future missions. This software is a Perl script intended for use in the mission operations UNIX environment. It is designed for use to support the MRO (Mars Reconnaissance Orbiter) instrument team. The tool also provides automated DOM (Distributed Object Manager) storage into the special ITAR-okay DOM collection, and can be used for creating focused RSOEs for product review by any of the MRO teams.

Auto-Associative Recurrent Neural Networks and Long Term Dependencies in Novelty Detection for Audio Surveillance Applications

NASA Astrophysics Data System (ADS)

Rossi, A.; Montefoschi, F.; Rizzo, A.; Diligenti, M.; Festucci, C.

2017-10-01

Machine Learning applied to Automatic Audio Surveillance has been attracting increasing attention in recent years. In spite of several investigations based on a large number of different approaches, little attention had been paid to the environmental temporal evolution of the input signal. In this work, we propose an exploration in this direction comparing the temporal correlations extracted at the feature level with the one learned by a representational structure. To this aim we analysed the prediction performances of a Recurrent Neural Network architecture varying the length of the processed input sequence and the size of the time window used in the feature extraction. Results corroborated the hypothesis that sequential models work better when dealing with data characterized by temporal order. However, so far the optimization of the temporal dimension remains an open issue.

Emergence of artistic talent in frontotemporal dementia.

PubMed

Miller, B L; Cummings, J; Mishkin, F; Boone, K; Prince, F; Ponton, M; Cotman, C

1998-10-01

To describe the clinical, neuropsychological, and imaging features of five patients with frontotemporal dementia (FTD) who acquired new artistic skills in the setting of dementia. Creativity in the setting of dementia has recently been reported. We describe five patients who became visual artists in the setting of FTD. Sixty-nine FTD patients were interviewed regarding visual abilities. Five became artists in the early stages of FTD. Their history, artistic process, neuropsychology, and anatomy are described. On SPECT or pathology, four of the five patients had the temporal variant of FTD in which anterior temporal lobes are involved but the dorsolateral frontal cortex is spared. Visual skills were spared but language and social skills were devastated. Loss of function in the anterior temporal lobes may lead to the "facilitation" of artistic skills. Patients with the temporal lobe variant of FTD offer a window into creativity.

Injuries Associated with Specific Motor Vehicle Hazards: Radiators, Batteries, Power Windows, and Power Roofs

DOT National Transportation Integrated Search

1997-07-01

This report provides estimates of the numbers of persons injured as a result of : hazards involving four specific motor vehicle components: radiators, batteries, : power windows, and power roofs. The injury estimates are based upon data from : the Co...

Neural plasticity associated with recently versus often heard objects.

PubMed

Bourquin, Nathalie M-P; Spierer, Lucas; Murray, Micah M; Clarke, Stephanie

2012-09-01

In natural settings the same sound source is often heard repeatedly, with variations in spectro-temporal and spatial characteristics. We investigated how such repetitions influence sound representations and in particular how auditory cortices keep track of recently vs. often heard objects. A set of 40 environmental sounds was presented twice, i.e. as prime and as repeat, while subjects categorized the corresponding sound sources as living vs. non-living. Electrical neuroimaging analyses were applied to auditory evoked potentials (AEPs) comparing primes vs. repeats (effect of presentation) and the four experimental sections. Dynamic analysis of distributed source estimations revealed i) a significant main effect of presentation within the left temporal convexity at 164-215 ms post-stimulus onset; and ii) a significant main effect of section in the right temporo-parietal junction at 166-213 ms. A 3-way repeated measures ANOVA (hemisphere×presentation×section) applied to neural activity of the above clusters during the common time window confirmed the specificity of the left hemisphere for the effect of presentation, but not that of the right hemisphere for the effect of section. In conclusion, spatio-temporal dynamics of neural activity encode the temporal history of exposure to sound objects. Rapidly occurring plastic changes within the semantic representations of the left hemisphere keep track of objects heard a few seconds before, independent of the more general sound exposure history. Progressively occurring and more long-lasting plastic changes occurring predominantly within right hemispheric networks, which are known to code for perceptual, semantic and spatial aspects of sound objects, keep track of multiple exposures. Copyright © 2012 Elsevier Inc. All rights reserved.

Speech processing: from peripheral to hemispheric asymmetry of the auditory system.

PubMed

Lazard, Diane S; Collette, Jean-Louis; Perrot, Xavier

2012-01-01

Language processing from the cochlea to auditory association cortices shows side-dependent specificities with an apparent left hemispheric dominance. The aim of this article was to propose to nonspeech specialists a didactic review of two complementary theories about hemispheric asymmetry in speech processing. Starting from anatomico-physiological and clinical observations of auditory asymmetry and interhemispheric connections, this review then exposes behavioral (dichotic listening paradigm) as well as functional (functional magnetic resonance imaging and positron emission tomography) experiments that assessed hemispheric specialization for speech processing. Even though speech at an early phonological level is regarded as being processed bilaterally, a left-hemispheric dominance exists for higher-level processing. This asymmetry may arise from a segregation of the speech signal, broken apart within nonprimary auditory areas in two distinct temporal integration windows--a fast one on the left and a slower one on the right--modeled through the asymmetric sampling in time theory or a spectro-temporal trade-off, with a higher temporal resolution in the left hemisphere and a higher spectral resolution in the right hemisphere, modeled through the spectral/temporal resolution trade-off theory. Both theories deal with the concept that lower-order tuning principles for acoustic signal might drive higher-order organization for speech processing. However, the precise nature, mechanisms, and origin of speech processing asymmetry are still being debated. Finally, an example of hemispheric asymmetry alteration, which has direct clinical implications, is given through the case of auditory aging that mixes peripheral disorder and modifications of central processing. Copyright © 2011 The American Laryngological, Rhinological, and Otological Society, Inc.

Brain response during the M170 time interval is sensitive to socially relevant information.

PubMed

Arviv, Oshrit; Goldstein, Abraham; Weeting, Janine C; Becker, Eni S; Lange, Wolf-Gero; Gilboa-Schechtman, Eva

2015-11-01

Deciphering the social meaning of facial displays is a highly complex neurological process. The M170, an event related field component of MEG recording, like its EEG counterpart N170, was repeatedly shown to be associated with structural encoding of faces. However, the scope of information encoded during the M170 time window is still being debated. We investigated the neuronal origin of facial processing of integrated social rank cues (SRCs) and emotional facial expressions (EFEs) during the M170 time interval. Participants viewed integrated facial displays of emotion (happy, angry, neutral) and SRCs (indicated by upward, downward, or straight head tilts). We found that the activity during the M170 time window is sensitive to both EFEs and SRCs. Specifically, highly prominent activation was observed in response to SRC connoting dominance as compared to submissive or egalitarian head cues. Interestingly, the processing of EFEs and SRCs appeared to rely on different circuitry. Our findings suggest that vertical head tilts are processed not only for their sheer structural variance, but as social information. Exploring the temporal unfolding and brain localization of non-verbal cues processing may assist in understanding the functioning of the social rank biobehavioral system. Copyright © 2015 Elsevier Ltd. All rights reserved.

Highly Insulating Windows Volume Purchase Program Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2013-04-01

This report documents the development, execution outcomes and lessons learned of the Highly Insulating Windows Volume Purchase (WVP) Program carried out over a three-year period from 2009 through 2012. The primary goals of the program were met: 1) reduce the incremental cost of highly insulating windows compared to ENERGY STAR windows; and 2) raise the public and potential buyers’ awareness of highly insulating windows and their benefits. A key outcome of the program is that the 2013 ENERGY STAR Most Efficient criteria for primary residential windows were adopted from the technical specifications set forth in the WVP program.

An Efficient Adaptive Window Size Selection Method for Improving Spectrogram Visualization.

PubMed

Nisar, Shibli; Khan, Omar Usman; Tariq, Muhammad

2016-01-01

Short Time Fourier Transform (STFT) is an important technique for the time-frequency analysis of a time varying signal. The basic approach behind it involves the application of a Fast Fourier Transform (FFT) to a signal multiplied with an appropriate window function with fixed resolution. The selection of an appropriate window size is difficult when no background information about the input signal is known. In this paper, a novel empirical model is proposed that adaptively adjusts the window size for a narrow band-signal using spectrum sensing technique. For wide-band signals, where a fixed time-frequency resolution is undesirable, the approach adapts the constant Q transform (CQT). Unlike the STFT, the CQT provides a varying time-frequency resolution. This results in a high spectral resolution at low frequencies and high temporal resolution at high frequencies. In this paper, a simple but effective switching framework is provided between both STFT and CQT. The proposed method also allows for the dynamic construction of a filter bank according to user-defined parameters. This helps in reducing redundant entries in the filter bank. Results obtained from the proposed method not only improve the spectrogram visualization but also reduce the computation cost and achieves 87.71% of the appropriate window length selection.

Dissociating sensory from decision processes in human perceptual decision making.

PubMed

Mostert, Pim; Kok, Peter; de Lange, Floris P

2015-12-15

A key question within systems neuroscience is how the brain translates physical stimulation into a behavioral response: perceptual decision making. To answer this question, it is important to dissociate the neural activity underlying the encoding of sensory information from the activity underlying the subsequent temporal integration into a decision variable. Here, we adopted a decoding approach to empirically assess this dissociation in human magnetoencephalography recordings. We used a functional localizer to identify the neural signature that reflects sensory-specific processes, and subsequently traced this signature while subjects were engaged in a perceptual decision making task. Our results revealed a temporal dissociation in which sensory processing was limited to an early time window and consistent with occipital areas, whereas decision-related processing became increasingly pronounced over time, and involved parietal and frontal areas. We found that the sensory processing accurately reflected the physical stimulus, irrespective of the eventual decision. Moreover, the sensory representation was stable and maintained over time when it was required for a subsequent decision, but unstable and variable over time when it was task-irrelevant. In contrast, decision-related activity displayed long-lasting sustained components. Together, our approach dissects neuro-anatomically and functionally distinct contributions to perceptual decisions.

Dissociating sensory from decision processes in human perceptual decision making

PubMed Central

Mostert, Pim; Kok, Peter; de Lange, Floris P.

2015-01-01

A key question within systems neuroscience is how the brain translates physical stimulation into a behavioral response: perceptual decision making. To answer this question, it is important to dissociate the neural activity underlying the encoding of sensory information from the activity underlying the subsequent temporal integration into a decision variable. Here, we adopted a decoding approach to empirically assess this dissociation in human magnetoencephalography recordings. We used a functional localizer to identify the neural signature that reflects sensory-specific processes, and subsequently traced this signature while subjects were engaged in a perceptual decision making task. Our results revealed a temporal dissociation in which sensory processing was limited to an early time window and consistent with occipital areas, whereas decision-related processing became increasingly pronounced over time, and involved parietal and frontal areas. We found that the sensory processing accurately reflected the physical stimulus, irrespective of the eventual decision. Moreover, the sensory representation was stable and maintained over time when it was required for a subsequent decision, but unstable and variable over time when it was task-irrelevant. In contrast, decision-related activity displayed long-lasting sustained components. Together, our approach dissects neuro-anatomically and functionally distinct contributions to perceptual decisions. PMID:26666393

Specific features of thermocouple calorimeter application for measurements of pulsed X-ray emission from plasma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gavrilov, V. V.; Fasakhov, I. K.

2012-01-15

It is shown that the accuracy of time-integrated measurements of pulsed X-ray emission from hot plasma with calibrated thermocouple calorimeters is mainly determined by two factors. The first and the most important factor is heating of the filter by the absorbed X-rays; as a result, the calorimeter measures the thermal radiation of the filter, which causes appreciable distortion of the temporal profile and amplitude of the recorded signal. The second factor is the dependence of the effective depth of X-ray absorption in the dielectric that covers the entrance window of the calorimeter on the energy of X-ray photons, i.e., onmore » the recorded radiation spectrum. The results of model calculations of the calorimeter signal are compared with the experimental data.« less

The Crista Fenestra and Its Impact on the Surgical Approach to the Scala Tympani during Cochlear Implantation.

PubMed

Angeli, Roberto D; Lavinsky, Joel; Setogutti, Enio T; Lavinsky, Luiz

2017-01-01

The aim of this work was to describe the dimensions of the crista fenestra and determine its presence by means of high-resolution computed tomography (CT) for the purpose of cochlear implantation via the round window approach. A series of 10 adult human temporal bones underwent high-resolution CT scanning and were further dissected for microscopic study of the round window niche. In all of the specimens, the round window membrane was fully visualized after the complete removal of bony overhangs. The crista fenestra was identified as a sharp bony crest located in the anterior and inferior borders of the niche; its area ranged from 0.28 to 0.80 mm2 (mean 0.51 ± 0.18). The proportion of the area occupied by the crista fenestra in the whole circumference of the round window ranged from 23 to 50% (mean 36%). We found a moderate positive correlation between the area of the niche and the dimensions of the crista fenestra (Spearman rho: 0.491). In every case, high-resolution CT scanning was unable to determine the presence of the crista fenestra. The crista fenestra occupies a variable but expressive area within the bony round window niche. Narrower round window niches tended to house smaller crests. The presence of the crista fenestra is an important obstacle to adequate access to the scala tympani. Nevertheless, a high-resolution CT scan provides no additional preoperative information with regard to its presence for the purpose of surgical access to the scala tympani via the round window niche. © 2017 S. Karger AG, Basel.

Neural measures of the role of affective prosody in empathy for pain.

PubMed

Meconi, Federica; Doro, Mattia; Lomoriello, Arianna Schiano; Mastrella, Giulia; Sessa, Paola

2018-01-10

Emotional communication often needs the integration of affective prosodic and semantic components from speech and the speaker's facial expression. Affective prosody may have a special role by virtue of its dual-nature; pre-verbal on one side and accompanying semantic content on the other. This consideration led us to hypothesize that it could act transversely, encompassing a wide temporal window involving the processing of facial expressions and semantic content expressed by the speaker. This would allow powerful communication in contexts of potential urgency such as witnessing the speaker's physical pain. Seventeen participants were shown with faces preceded by verbal reports of pain. Facial expressions, intelligibility of the semantic content of the report (i.e., participants' mother tongue vs. fictional language) and the affective prosody of the report (neutral vs. painful) were manipulated. We monitored event-related potentials (ERPs) time-locked to the onset of the faces as a function of semantic content intelligibility and affective prosody of the verbal reports. We found that affective prosody may interact with facial expressions and semantic content in two successive temporal windows, supporting its role as a transverse communication cue.

Can a national dataset generate a nomogram for necrotizing enterocolitis onset?

PubMed

Gordon, P V; Clark, R; Swanson, J R; Spitzer, A

2014-10-01

Mother's own milk and donor human milk use is increasing as a means of necrotizing enterocolitis (NEC) prevention. Early onset of enteral feeding has been associated with improvement of many outcomes but has not been shown to reduce the incidence of NEC. Better definition of the window of risk for NEC by gestational strata should improve resource management with respect to donor human milk and enhance our understanding of NEC timing and pathogenesis. Our objective was to establish a NEC dataset of sufficient size and quality, then build a generalizable model of NEC onset from the dataset across gestational strata. We used de-identified data from the Pediatrix national dataset and filtered out all diagnostic confounders that could be identified by either specific diagnoses or logical exclusions (example dual diagnoses), with a specific focus on NEC and spontaneous intestinal perforation (SIP) as the outcomes of interest. The median day of onset was plotted against the gestational age for each of these diagnoses and analyzed for similarities and differences in the day of diagnosis. Onset time of medical NEC was inversely proportional to gestation in a linear relationship across all gestational ages. We found the medical NEC dataset displayed characteristics most consistent with a homogeneous disease entity, whereas there was a skew towards early presentation in the youngest gestation groups of surgical NEC (suggesting probable SIP contamination). Our national dataset demonstrates that NEC onset occurs in an inverse stereotypic, linear relationship with gestational age at birth. Medical NEC is the most reliable sub-cohort for the purpose of determining the temporal window of NEC risk.

Temporal relation between top-down and bottom-up processing in lexical tone perception

PubMed Central

Shuai, Lan; Gong, Tao

2013-01-01

Speech perception entails both top-down processing that relies primarily on language experience and bottom-up processing that depends mainly on instant auditory input. Previous models of speech perception often claim that bottom-up processing occurs in an early time window, whereas top-down processing takes place in a late time window after stimulus onset. In this paper, we evaluated the temporal relation of both types of processing in lexical tone perception. We conducted a series of event-related potential (ERP) experiments that recruited Mandarin participants and adopted three experimental paradigms, namely dichotic listening, lexical decision with phonological priming, and semantic violation. By systematically analyzing the lateralization patterns of the early and late ERP components that are observed in these experiments, we discovered that: auditory processing of pitch variations in tones, as a bottom-up effect, elicited greater right hemisphere activation; in contrast, linguistic processing of lexical tones, as a top-down effect, elicited greater left hemisphere activation. We also found that both types of processing co-occurred in both the early (around 200 ms) and late (around 300–500 ms) time windows, which supported a parallel model of lexical tone perception. Unlike the previous view that language processing is special and performed by dedicated neural circuitry, our study have elucidated that language processing can be decomposed into general cognitive functions (e.g., sensory and memory) and share neural resources with these functions. PMID:24723863

The effect of length and starting year on trend analyses of temperatures in Spanish mainland (1951-2010). Seasonal analyses: Autumn (V)

NASA Astrophysics Data System (ADS)

Salinas Solé, Celia; Peña Angulo, Dhais; Gonzalez HIgaldo, Jose Carlos; Brunetti, MIchele

2017-04-01

In this poster we applied the moving window approach (see Poster I of this collection) to analyze trends of autumn and its corresponding months (September, October, November) temperature mean values of maximum (Tmax) and minimum (Tmin) in Spanish mainland to detect the effects of length period and starting year. Monthly series belong to Monthly Temperature dataset of Spanish mainland (MOTEDAS). Database contains in its grid format of 5236 pixels of monthly series (10x10 km). The threshold used in spatial analyses considers 20% of land under significant trend (p<0.05). The most striking results are as follow: • Seasonal trend analyses of Autumn Tmax show no significance at any temporal Windows. Trends of Tmin are significant in more than 20% of land until 1974-2010. The area affected in Tmin progressively increase from SE to NW. • Monthly trend analyses not detect any significance in Tmax, while in Tmin, particularly in October, an extended area is detected in temporal windows in between 1951-2010 to 1978-2010, but clearly concentrated in the starting years of initial 70´s. Spatial pattern of areas affected significantly seems to be from SE to NW for October, and South-North in September. To conclude autumn trend analyses of Tmax and Tmin in Spanish mainland only detect significant trend in Tmin, mostly located in the 70´s and extending from SE to central areas of study area.

Temporal processing deficit leads to impaired multisensory binding in schizophrenia.

PubMed

Zvyagintsev, Mikhail; Parisi, Carmen; Mathiak, Klaus

2017-09-01

Schizophrenia has been characterised by neurodevelopmental dysconnectivity resulting in cognitive and perceptual dysmetria. Hence patients with schizophrenia may be impaired to detect the temporal relationship between stimuli in different sensory modalities. However, only a few studies described deficit in perception of temporally asynchronous multisensory stimuli in schizophrenia. We examined the perceptual bias and the processing time of synchronous and delayed sounds in the streaming-bouncing illusion in 16 patients with schizophrenia and a matched control group of 18 participants. Equal for patients and controls, the synchronous sound biased the percept of two moving squares towards bouncing as opposed to the more frequent streaming percept in the condition without sound. In healthy controls, a delay of the sound presentation significantly reduced the bias and led to prolonged processing time whereas patients with schizophrenia did not differentiate between this condition and the condition with synchronous sound. Schizophrenia leads to a prolonged window of simultaneity for audiovisual stimuli. Therefore, temporal processing deficit in schizophrenia can lead to hyperintegration of temporally unmatched multisensory stimuli.

Prism Window for Optical Alignment

NASA Technical Reports Server (NTRS)

Tang, Hong

2008-01-01

A prism window has been devised for use, with an autocollimator, in aligning optical components that are (1) required to be oriented parallel to each other and/or at a specified angle of incidence with respect to a common optical path and (2) mounted at different positions along the common optical path. The prism window can also be used to align a single optical component at a specified angle of incidence. Prism windows could be generally useful for orienting optical components in manufacture of optical instruments. "Prism window" denotes an application-specific unit comprising two beam-splitter windows that are bonded together at an angle chosen to obtain the specified angle of incidence.

A single-shot spatial chirp method for measuring initial AC conductivity evolution of femtosecond laser pulse excited warm dense matter

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Z.; Hering, P.; Brown, S. B.

To study the rapid evolution of AC conductivity from ultrafast laser excited warm dense matter (WDM), a spatial chirp single-shot method is developed utilizing a crossing angle pump-probe configuration. The pump beam is shaped individually in two spatial dimensions so that it can provide both sufficient laser intensity to excite the material to warm dense matter state and a uniform time window of up to 1 ps with sub-100 fs FWHM temporal resolution. Here, temporal evolution of AC conductivity in laser excited warm dense gold was also measured.

A single-shot spatial chirp method for measuring initial AC conductivity evolution of femtosecond laser pulse excited warm dense matter

DOE PAGES

Chen, Z.; Hering, P.; Brown, S. B.; ...

2016-09-19

To study the rapid evolution of AC conductivity from ultrafast laser excited warm dense matter (WDM), a spatial chirp single-shot method is developed utilizing a crossing angle pump-probe configuration. The pump beam is shaped individually in two spatial dimensions so that it can provide both sufficient laser intensity to excite the material to warm dense matter state and a uniform time window of up to 1 ps with sub-100 fs FWHM temporal resolution. Here, temporal evolution of AC conductivity in laser excited warm dense gold was also measured.

A risk-informed decision framework for setting environmental windows for dredging projects.

PubMed

Suedel, Burton C; Kim, Jongbum; Clarke, Douglas G; Linkov, Igor

2008-09-15

Sediment dredging is necessary to sustain navigation infrastructure in ports and harbor areas. In the United States alone between 250 and 300 million cubic yards of sediment are dredged annually. Dredging activities may cause stress on aquatic biota by locally increasing turbidity and suspended sediment concentrations, physically disturbing habitat by elevated sedimentation rates, interfering in migratory behaviors, and hydraulically entraining bottom dwelling organisms. Environmental windows are a management practice used to alleviate such stresses on resident and transient biota by placing temporal restrictions on the conduct of dredging operations. Adherence to environmental windows can significantly inflate costs for project sponsors and local stakeholders. Since their inception following passage of NEPA in 1969 the process for setting environmental windows has not followed structured procedures and represents an example of the difficulty inherent in achieving a balance between biological resource protection and cost-effective construction and maintenance of navigation infrastructure. Recent developments in the fields of risk assessment for non-chemical stressors as well as experience in implementing structured risk-informed decision-making tools for sediment and natural resource management are summarized in this paper in relation to setting environmental windows. Combining risk assessment and multi-criteria decision analysis allows development of a framework for an objective process consistent with recommendations by the National Academy of Sciences for setting environmental windows. A hypothetical application of the framework for protection of Pacific herring (Clupea pallasii) in San Francisco Bay is discussed.

a Spiral-Based Downscaling Method for Generating 30 M Time Series Image Data

NASA Astrophysics Data System (ADS)

Liu, B.; Chen, J.; Xing, H.; Wu, H.; Zhang, J.

2017-09-01

The spatial detail and updating frequency of land cover data are important factors influencing land surface dynamic monitoring applications in high spatial resolution scale. However, the fragmentized patches and seasonal variable of some land cover types (e. g. small crop field, wetland) make it labor-intensive and difficult in the generation of land cover data. Utilizing the high spatial resolution multi-temporal image data is a possible solution. Unfortunately, the spatial and temporal resolution of available remote sensing data like Landsat or MODIS datasets can hardly satisfy the minimum mapping unit and frequency of current land cover mapping / updating at the same time. The generation of high resolution time series may be a compromise to cover the shortage in land cover updating process. One of popular way is to downscale multi-temporal MODIS data with other high spatial resolution auxiliary data like Landsat. But the usual manner of downscaling pixel based on a window may lead to the underdetermined problem in heterogeneous area, result in the uncertainty of some high spatial resolution pixels. Therefore, the downscaled multi-temporal data can hardly reach high spatial resolution as Landsat data. A spiral based method was introduced to downscale low spatial and high temporal resolution image data to high spatial and high temporal resolution image data. By the way of searching the similar pixels around the adjacent region based on the spiral, the pixel set was made up in the adjacent region pixel by pixel. The underdetermined problem is prevented to a large extent from solving the linear system when adopting the pixel set constructed. With the help of ordinary least squares, the method inverted the endmember values of linear system. The high spatial resolution image was reconstructed on the basis of high spatial resolution class map and the endmember values band by band. Then, the high spatial resolution time series was formed with these high spatial resolution images image by image. Simulated experiment and remote sensing image downscaling experiment were conducted. In simulated experiment, the 30 meters class map dataset Globeland30 was adopted to investigate the effect on avoid the underdetermined problem in downscaling procedure and a comparison between spiral and window was conducted. Further, the MODIS NDVI and Landsat image data was adopted to generate the 30m time series NDVI in remote sensing image downscaling experiment. Simulated experiment results showed that the proposed method had a robust performance in downscaling pixel in heterogeneous region and indicated that it was superior to the traditional window-based methods. The high resolution time series generated may be a benefit to the mapping and updating of land cover data.

Identifying sensitive windows for prenatal particulate air pollution exposure and mitochondrial DNA content in cord blood.

PubMed

Rosa, Maria José; Just, Allan C; Guerra, Marco Sánchez; Kloog, Itai; Hsu, Hsiao-Hsien Leon; Brennan, Kasey J; García, Adriana Mercado; Coull, Brent; Wright, Rosalind J; Téllez Rojo, Martha María; Baccarelli, Andrea A; Wright, Robert O

2017-01-01

Changes in mitochondrial DNA (mtDNA) can serve as a marker of cumulative oxidative stress (OS) due to the mitochondria's unique genome and relative lack of repair systems. In utero particulate matter ≤2.5μm (PM 2.5 ) exposure can enhance oxidative stress. Our objective was to identify sensitive windows to predict mtDNA damage experienced in the prenatal period due to PM 2.5 exposure using mtDNA content measured in cord blood. Women affiliated with the Mexican social security system were recruited during pregnancy in the Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS) study. Mothers with cord blood collected at delivery and complete covariate data were included (n=456). Mothers' prenatal daily exposure to PM 2.5 was estimated using a satellite-based spatio-temporally resolved prediction model and place of residence during pregnancy. DNA was extracted from umbilical cord leukocytes. Quantitative real-time polymerase chain reaction (qPCR) was used to determine mtDNA content. A distributive lag regression model (DLM) incorporating weekly averages of daily PM 2.5 predictions was constructed to plot the association between exposure and OS over the length of pregnancy. In models that included child's sex, mother's age at delivery, prenatal environmental tobacco smoke exposure, birth year, maternal education, and assay batch, we found significant associations between higher PM 2.5 exposure during late pregnancy (35-40weeks) and lower mtDNA content in cord blood. Increased PM 2.5 during a specific prenatal window in the third trimester was associated with decreased mtDNA content suggesting heightened sensitivity to PM-induced OS during this life stage. Copyright © 2016 Elsevier Ltd. All rights reserved.

Gamma ray spectroscopy employing divalent europium-doped alkaline earth halides and digital readout for accurate histogramming

DOEpatents

Cherepy, Nerine Jane; Payne, Stephen Anthony; Drury, Owen B.; Sturm, Benjamin W.

2016-02-09

According to one embodiment, a scintillator radiation detector system includes a scintillator, and a processing device for processing pulse traces corresponding to light pulses from the scintillator, where the processing device is configured to: process each pulse trace over at least two temporal windows and to use pulse digitization to improve energy resolution of the system. According to another embodiment, a scintillator radiation detector system includes a processing device configured to: fit digitized scintillation waveforms to an algorithm, perform a direct integration of fit parameters, process multiple integration windows for each digitized scintillation waveform to determine a correction factor, and apply the correction factor to each digitized scintillation waveform.

78 FR 22942 - Pilkington North America, Inc., Grant of Petition for Decision of Inconsequential Noncompliance

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-17

... replacement rear windows manufactured for model year 2006 through 2009 Honda Civic two-door coupe passenger... approximately 206 replacement rear windows (National Auto Glass Specifications (NAGS) part number FB22692GTY...: Pilkington explains that the noncompliance for the 205 replacement rear windows exists due to Pilkington's...

High performance sapphire windows

NASA Technical Reports Server (NTRS)

Bates, Stephen C.; Liou, Larry

1993-01-01

High-quality, wide-aperture optical access is usually required for the advanced laser diagnostics that can now make a wide variety of non-intrusive measurements of combustion processes. Specially processed and mounted sapphire windows are proposed to provide this optical access to extreme environment. Through surface treatments and proper thermal stress design, single crystal sapphire can be a mechanically equivalent replacement for high strength steel. A prototype sapphire window and mounting system have been developed in a successful NASA SBIR Phase 1 project. A large and reliable increase in sapphire design strength (as much as 10x) has been achieved, and the initial specifications necessary for these gains have been defined. Failure testing of small windows has conclusively demonstrated the increased sapphire strength, indicating that a nearly flawless surface polish is the primary cause of strengthening, while an unusual mounting arrangement also significantly contributes to a larger effective strength. Phase 2 work will complete specification and demonstration of these windows, and will fabricate a set for use at NASA. The enhanced capabilities of these high performance sapphire windows will lead to many diagnostic capabilities not previously possible, as well as new applications for sapphire.

High performance sapphire windows

NASA Astrophysics Data System (ADS)

Bates, Stephen C.; Liou, Larry

1993-02-01

High-quality, wide-aperture optical access is usually required for the advanced laser diagnostics that can now make a wide variety of non-intrusive measurements of combustion processes. Specially processed and mounted sapphire windows are proposed to provide this optical access to extreme environment. Through surface treatments and proper thermal stress design, single crystal sapphire can be a mechanically equivalent replacement for high strength steel. A prototype sapphire window and mounting system have been developed in a successful NASA SBIR Phase 1 project. A large and reliable increase in sapphire design strength (as much as 10x) has been achieved, and the initial specifications necessary for these gains have been defined. Failure testing of small windows has conclusively demonstrated the increased sapphire strength, indicating that a nearly flawless surface polish is the primary cause of strengthening, while an unusual mounting arrangement also significantly contributes to a larger effective strength. Phase 2 work will complete specification and demonstration of these windows, and will fabricate a set for use at NASA. The enhanced capabilities of these high performance sapphire windows will lead to many diagnostic capabilities not previously possible, as well as new applications for sapphire.

The impact of sex and language dominance on material-specific memory before and after left temporal lobe surgery.

PubMed

Helmstaedter, C; Brosch, T; Kurthen, M; Elger, C E

2004-07-01

Recent findings raised evidence that in early-onset left temporal lobe epilepsy, women show greater functional plasticity for verbal memory than men. In particular, women with lesion- or epilepsy-driven atypical language dominance show an advantage over men. The question asked in this study was whether there is evidence of sex- and language dominance-dependent late, i.e. adult age, plasticity for verbal memory when epilepsy surgery is performed in these patients. Pre- and 1-year postoperative memory performance was evaluated in 169 patients (94 males and 75 females) who underwent left temporal lobe surgery and who had WADA testing of hemispheric language dominance prior to surgery. Verbal memory and figural memory were assessed by list-learning paradigms. According to the Bonn intracarotid amobarbital test (IAT) protocol, patients were categorized into left dominant or atypically dominant (right, incomplete left or right, and bilateral dominant) groups. Results were controlled for the hypothesized sex differences. Thirty-four percent of men and 47% of women displayed patterns of atypical language dominance. Atypical dominance was related to an early onset of epilepsy. Men showed a larger time window for development of atypical dominance but, differently from women, the pattern of atypical dominance was more strictly determined by the age at onset of epilepsy. Atypically dominant women showed better verbal memory than typically dominant women or men. After surgery, right dominant patients had better verbal memory outcome than patients with bilateral or left language dominance who showed significant memory loss. No effect of sex on verbal memory change was found. Figural memory deteriorated in men and improved in women, when they were not left dominant. Seizure outcome had no effect on performance changes. It was concluded that better preserved verbal memory in atypically dominant women before surgery indicates greater benefit from atypical dominance in women than men with regard to the initial damage associated with left hemisphere epilepsy. Later in life, when epilepsy surgery causes additional damage, no such sex difference is observed, indicating that the women's advantage over men is fixed to an early time window in life. Postoperative changes in figural memory suggest dynamics in crowding and suppression patterns. Whether this reflects late plasticity and compensation needs further demonstration. For clinical practice, it is important to note that incomplete right hemisphere and bilateral language dominance do not protect against verbal memory loss after left-sided temporal lobe surgery. Copyright 2004 Guarantors of Brain

[Computed tomography of the temporal bone in diagnosis of chronic exudative otitis media].

PubMed

Zelikovich, E I

2005-01-01

Computed tomography (CT) of the temporal bone was made in 37 patients aged 2 to 55 years with chronic exudative otitis media (CEOM). In 21 of them the pathology was bilateral. The analysis of 58 CT images has identified CT signs of chronic exudative otitis media. They include partial (17 temporary bones) or complete (38 temporal bones) block of the bone opening of the auditory tube, pneumatic defects of the tympanic cavity (58 temporal bones), pneumatic defects of the mastoid process and antrum (47 temporal bones), pathologic retraction of the tympanic membrane. The examination of the temporal bone detected both CT-signs of CEOM and other causes of hearing disorders in 14 patients (26 temporal bones) with CEOM symptoms and inadequately high hypoacusis. Among these causes were malformation of the auditory ossicula (n=5), malformation of the labynthine window (n=2), malformation of the middle and internal ear (n=4), a wide aqueduct of the vestibule, labyrinthine anomaly of Mondini's type (n=1), cochlear hypoplasia (n=4), stenosis of the internal acoustic meatuses (n=2). Sclerotic fibrous dysplasia was suggested in 2 temporal bones (by CT data). CT was repeated after surgical treatment of 10 patients (14 temporal bones) and visual assessment of tympanostomy results was made.

HOTS: A Hierarchy of Event-Based Time-Surfaces for Pattern Recognition.

PubMed

Lagorce, Xavier; Orchard, Garrick; Galluppi, Francesco; Shi, Bertram E; Benosman, Ryad B

2017-07-01

This paper describes novel event-based spatio-temporal features called time-surfaces and how they can be used to create a hierarchical event-based pattern recognition architecture. Unlike existing hierarchical architectures for pattern recognition, the presented model relies on a time oriented approach to extract spatio-temporal features from the asynchronously acquired dynamics of a visual scene. These dynamics are acquired using biologically inspired frameless asynchronous event-driven vision sensors. Similarly to cortical structures, subsequent layers in our hierarchy extract increasingly abstract features using increasingly large spatio-temporal windows. The central concept is to use the rich temporal information provided by events to create contexts in the form of time-surfaces which represent the recent temporal activity within a local spatial neighborhood. We demonstrate that this concept can robustly be used at all stages of an event-based hierarchical model. First layer feature units operate on groups of pixels, while subsequent layer feature units operate on the output of lower level feature units. We report results on a previously published 36 class character recognition task and a four class canonical dynamic card pip task, achieving near 100 percent accuracy on each. We introduce a new seven class moving face recognition task, achieving 79 percent accuracy.This paper describes novel event-based spatio-temporal features called time-surfaces and how they can be used to create a hierarchical event-based pattern recognition architecture. Unlike existing hierarchical architectures for pattern recognition, the presented model relies on a time oriented approach to extract spatio-temporal features from the asynchronously acquired dynamics of a visual scene. These dynamics are acquired using biologically inspired frameless asynchronous event-driven vision sensors. Similarly to cortical structures, subsequent layers in our hierarchy extract increasingly abstract features using increasingly large spatio-temporal windows. The central concept is to use the rich temporal information provided by events to create contexts in the form of time-surfaces which represent the recent temporal activity within a local spatial neighborhood. We demonstrate that this concept can robustly be used at all stages of an event-based hierarchical model. First layer feature units operate on groups of pixels, while subsequent layer feature units operate on the output of lower level feature units. We report results on a previously published 36 class character recognition task and a four class canonical dynamic card pip task, achieving near 100 percent accuracy on each. We introduce a new seven class moving face recognition task, achieving 79 percent accuracy.

Transparency of 2μ m window of Titan's atmosphere

NASA Astrophysics Data System (ADS)

Rannou, P.; Seignovert, B.; Le Mouélic, S.; Maltagliati, L.; Rey, M.; Sotin, C.

2018-02-01

Titan's atmosphere is optically thick and hides the surface and the lower layers from the view at almost all wavelengths. However, because gaseous absorptions are spectrally selective, some narrow spectral intervals are relatively transparent and allow to probe the surface. To use these intervals (called windows) a good knowledge of atmospheric absorption is necessary. Once gas spectroscopic linelists are well established, the absorption inside windows depends on the way the far wings of the methane absorption lines are cut-off. We know that the intensity in all the windows can be explained with the same cut-off parameters, except for the window at 2 μm. This discrepancy is generally treated with a workaround which consists in using a different cut-off description for this specific window. This window is relatively transparent and surface may have specific spectral signatures that could be detected. Thus, a good knowledge of atmosphere opacities is essential and our scope is to better understand what causes the difference between the 2 μm window and the other windows. In this work, we used scattered light at the limb and transmissions in occultation observed with VIMS (Visual Infrared Mapping Spectrometer) onboard Cassini, around the 2 μm window. Data shows an absorption feature that participates to the shape of this window. Our atmospheric model fits well the VIMS data at 2 μm with the same cut-off than for the other windows, provided an additional absorption is introduced in the middle of the window around ≃ 2.065 μm. It explains well the discrepency between the cut-off used at 2 μm, and we show that a gas with a fairly constant mixing ratio, possibly ethane, may be the cause of this absorption. Finally, we studied the impact of this absorption on the retrieval of the surface reflectivity and found that it is significant.

Support Vector Data Description Model to Map Specific Land Cover with Optimal Parameters Determined from a Window-Based Validation Set.

PubMed

Zhang, Jinshui; Yuan, Zhoumiqi; Shuai, Guanyuan; Pan, Yaozhong; Zhu, Xiufang

2017-04-26

This paper developed an approach, the window-based validation set for support vector data description (WVS-SVDD), to determine optimal parameters for support vector data description (SVDD) model to map specific land cover by integrating training and window-based validation sets. Compared to the conventional approach where the validation set included target and outlier pixels selected visually and randomly, the validation set derived from WVS-SVDD constructed a tightened hypersphere because of the compact constraint by the outlier pixels which were located neighboring to the target class in the spectral feature space. The overall accuracies for wheat and bare land achieved were as high as 89.25% and 83.65%, respectively. However, target class was underestimated because the validation set covers only a small fraction of the heterogeneous spectra of the target class. The different window sizes were then tested to acquire more wheat pixels for validation set. The results showed that classification accuracy increased with the increasing window size and the overall accuracies were higher than 88% at all window size scales. Moreover, WVS-SVDD showed much less sensitivity to the untrained classes than the multi-class support vector machine (SVM) method. Therefore, the developed method showed its merits using the optimal parameters, tradeoff coefficient ( C ) and kernel width ( s ), in mapping homogeneous specific land cover.

Individual Differences in the Multisensory Temporal Binding Window Predict Susceptibility to Audiovisual Illusions

ERIC Educational Resources Information Center

Stevenson, Ryan A.; Zemtsov, Raquel K.; Wallace, Mark T.

2012-01-01

Human multisensory systems are known to bind inputs from the different sensory modalities into a unified percept, a process that leads to measurable behavioral benefits. This integrative process can be observed through multisensory illusions, including the McGurk effect and the sound-induced flash illusion, both of which demonstrate the ability of…

UAVSAR: An Airborne Window on Earth Surface Deformation

NASA Technical Reports Server (NTRS)

Hensley, Scott

2011-01-01

This study demonstrates that UAVSAR's precision autopilot and electronic steering have allowed for the reliable collection of airborne repeat pass radar interferometric data for deformation mapping. Deformation maps from temporal scales ranging from hours to months over a variety of signals of geophysical interest illustrate the utility of UAVSAR airborne repeat pass interferometry to these studies.

Ultrafast chirped optical waveform recording using referenced heterodyning and a time microscope

DOEpatents

Bennett, Corey Vincent

2010-06-15

A new technique for capturing both the amplitude and phase of an optical waveform is presented. This technique can capture signals with many THz of bandwidths in a single shot (e.g., temporal resolution of about 44 fs), or be operated repetitively at a high rate. That is, each temporal window (or frame) is captured single shot, in real time, but the process may be run repeatedly or single-shot. This invention expands upon previous work in temporal imaging by adding heterodyning, which can be self-referenced for improved precision and stability, to convert frequency chirp (the second derivative of phase with respect to time) into a time varying intensity modulation. By also including a variety of possible demultiplexing techniques, this process is scalable to recoding continuous signals.

Ultrafast chirped optical waveform recorder using referenced heterodyning and a time microscope

DOEpatents

Bennett, Corey Vincent [Livermore, CA

2011-11-22

A new technique for capturing both the amplitude and phase of an optical waveform is presented. This technique can capture signals with many THz of bandwidths in a single shot (e.g., temporal resolution of about 44 fs), or be operated repetitively at a high rate. That is, each temporal window (or frame) is captured single shot, in real time, but the process may be run repeatedly or single-shot. This invention expands upon previous work in temporal imaging by adding heterodyning, which can be self-referenced for improved precision and stability, to convert frequency chirp (the second derivative of phase with respect to time) into a time varying intensity modulation. By also including a variety of possible demultiplexing techniques, this process is scalable to recoding continuous signals.

Applications of Space-Time Duality

NASA Astrophysics Data System (ADS)

Plansinis, Brent W.

The concept of space-time duality is based on a mathematical analogy between paraxial diffraction and narrowband dispersion, and has led to the development of temporal imaging systems. The first part of this thesis focuses on the development of a temporal imaging system for the Laboratory for Laser Energetics. Using an electro-optic phase modulator as a time lens, a time-to-frequency converter is constructed capable of imaging pulses between 3 and 12 ps. Numerical simulations show how this system can be improved to image the 1-30 ps range used in OMEGA-EP. By adjusting the timing between the pulse and the sinusoidal clock of the phase modulator, the pulse spectrum can be selectively narrowed, broadened, or shifted. An experimental demonstration of this effect achieved spectral narrowing and broadening by a factor of 2. Numerical simulations show narrowing by a factor of 8 is possible with modern phase modulators. The second part of this thesis explores the space-time analog of reflection and refraction from a moving refractive index boundary. From a physics perspective, a temporal boundary breaks translational symmetry in time, requiring the momentum of the photon to remain unchanged while its energy may change. This leads to a shifting and splitting of the pulse spectrum as the boundary is crossed. Equations for the reflected and transmitted frequencies and a condition for total internal reflection are found. Two of these boundaries form a temporal waveguide, which confines the pulse to a narrow temporal window. These waveguides have a finite number of modes, which do not change during propagation. A single-mode waveguide can be created, allowing only a single pulse shape to form within the waveguide. Temporal reflection and refraction produce a frequency dependent phase shift on the incident pulse, leading to interference fringes between the incident light and the reflected light. In a waveguide, this leads to self-imaging, where the pulse shape reforms periodically at finite propagation lengths. Numerical simulations are performed for the specific case where the moving boundary is produced through cross-phase modulation. In this case, the Kerr nonlinearity causes the boundary to change during propagation, leading to unique temporal and spectral behavior.

Single-trial EEG-informed fMRI reveals spatial dependency of BOLD signal on early and late IC-ERP amplitudes during face recognition.

PubMed

Wirsich, Jonathan; Bénar, Christian; Ranjeva, Jean-Philippe; Descoins, Médéric; Soulier, Elisabeth; Le Troter, Arnaud; Confort-Gouny, Sylviane; Liégeois-Chauvel, Catherine; Guye, Maxime

2014-10-15

Simultaneous EEG-fMRI has opened up new avenues for improving the spatio-temporal resolution of functional brain studies. However, this method usually suffers from poor EEG quality, especially for evoked potentials (ERPs), due to specific artifacts. As such, the use of EEG-informed fMRI analysis in the context of cognitive studies has particularly focused on optimizing narrow ERP time windows of interest, which ignores the rich diverse temporal information of the EEG signal. Here, we propose to use simultaneous EEG-fMRI to investigate the neural cascade occurring during face recognition in 14 healthy volunteers by using the successive ERP peaks recorded during the cognitive part of this process. N170, N400 and P600 peaks, commonly associated with face recognition, were successfully and reproducibly identified for each trial and each subject by using a group independent component analysis (ICA). For the first time we use this group ICA to extract several independent components (IC) corresponding to the sequence of activation and used single-trial peaks as modulation parameters in a general linear model (GLM) of fMRI data. We obtained an occipital-temporal-frontal stream of BOLD signal modulation, in accordance with the three successive IC-ERPs providing an unprecedented spatio-temporal characterization of the whole cognitive process as defined by BOLD signal modulation. By using this approach, the pattern of EEG-informed BOLD modulation provided improved characterization of the network involved than the fMRI-only analysis or the source reconstruction of the three ERPs; the latter techniques showing only two regions in common localized in the occipital lobe. Copyright © 2014 Elsevier Inc. All rights reserved.

Increased frequency of temporal acoustic window failure in rheumatoid arthritis: a manifestation of altered bone metabolism?

PubMed

Kardos, Zsófia; Oláh, Csaba; Sepsi, Mariann; Sas, Attila; Kostyál, László; Bóta, Tünde; Bhattoa, Harjit Pal; Hodosi, Katalin; Kerekes, György; Tamási, László; Bereczki, Dániel; Szekanecz, Zoltán

2018-05-01

Assessment of intracranial vessels includes transcranial Doppler (TCD). TCD performance requires intact temporal acoustic windows (TAW). Failure of TAW (TAWF) is present in 8-20% of people. There have been no reports on TAWF in rheumatoid arthritis (RA). Altogether, 62 female RA patients were included. Among them, 20 were MTX-treated and biologic-free, 20 received infliximab, and 22 tocilizumab. The controls included 60 non-RA women. TAWF, temporal bone thickness, and texture were determined by ultrasound and CT. BMD and T-scores of multiple bones were determined by DEXA. Several bone biomarkers were assessed by ELISA. In RA, 54.8% of the patients had TAWF on at least one side. Neither TAW could be identified in 34% of RA subjects. In contrast, only 20.0% of control subjects had TAWF on either or both sides (p < 0.001). In RA vs controls, 53.0 vs 2.9% of subjects exerted the trilayer, "sandwich-like" structure of TAW (p < 0.001). Finally, in RA vs controls, the mean temporal bone thickness values of the right TAW were 3.58 ± 1.43 vs 2.92 ± 1.22 mm (p = NS), while those of the left TAW were 4.16 ± 1.56 vs 2.90 ± 1.16 mm (p = 0.001). There was close association between TAWF, bone thickness, and texture (p < 0.05). These TAW parameters all correlated with age; however, TAW failure and texture also correlated with serum osteoprotegerin. TAW bone thickness inversely correlated with hip BMD (p < 0.05). TAWF, thicker, and heterogeneous temporal bones were associated with RA. These features have been associated with bone loss and OPG production. Bone loss seen in RA may result in OPG release and stimulation of bone formation around TAW.

Thresholds of Auditory-Motor Coupling Measured with a Simple Task in Musicians and Non-Musicians: Was the Sound Simultaneous to the Key Press?

PubMed Central

van Vugt, Floris T.; Tillmann, Barbara

2014-01-01

The human brain is able to predict the sensory effects of its actions. But how precise are these predictions? The present research proposes a tool to measure thresholds between a simple action (keystroke) and a resulting sound. On each trial, participants were required to press a key. Upon each keystroke, a woodblock sound was presented. In some trials, the sound came immediately with the downward keystroke; at other times, it was delayed by a varying amount of time. Participants were asked to verbally report whether the sound came immediately or was delayed. Participants' delay detection thresholds (in msec) were measured with a staircase-like procedure. We hypothesised that musicians would have a lower threshold than non-musicians. Comparing pianists and brass players, we furthermore hypothesised that, as a result of a sharper attack of the timbre of their instrument, pianists might have lower thresholds than brass players. Our results show that non-musicians exhibited higher thresholds for delay detection (180±104 ms) than the two groups of musicians (102±65 ms), but there were no differences between pianists and brass players. The variance in delay detection thresholds could be explained by variance in sensorimotor synchronisation capacities as well as variance in a purely auditory temporal irregularity detection measure. This suggests that the brain's capacity to generate temporal predictions of sensory consequences can be decomposed into general temporal prediction capacities together with auditory-motor coupling. These findings indicate that the brain has a relatively large window of integration within which an action and its resulting effect are judged as simultaneous. Furthermore, musical expertise may narrow this window down, potentially due to a more refined temporal prediction. This novel paradigm provides a simple test to estimate the temporal precision of auditory-motor action-effect coupling, and the paradigm can readily be incorporated in studies investigating both healthy and patient populations. PMID:24498299

Optimization of ramp area aircraft push back time windows in the presence of uncertainty

NASA Astrophysics Data System (ADS)

Coupe, William Jeremy

It is well known that airport surface traffic congestion at major airports is responsible for increased taxi-out times, fuel burn and excess emissions and there is potential to mitigate these negative consequences through optimizing airport surface traffic operations. Due to a highly congested voice communication channel between pilots and air traffic controllers and a data communication channel that is used only for limited functions, one of the most viable near-term strategies for improvement of the surface traffic is issuing a push back advisory to each departing aircraft. This dissertation focuses on the optimization of a push back time window for each departing aircraft. The optimization takes into account both spatial and temporal uncertainties of ramp area aircraft trajectories. The uncertainties are described by a stochastic kinematic model of aircraft trajectories, which is used to infer distributions of combinations of push back times that lead to conflict among trajectories from different gates. The model is validated and the distributions are included in the push back time window optimization. Under the assumption of a fixed taxiway spot schedule, the computed push back time windows can be integrated with a higher level taxiway scheduler to optimize the flow of traffic from the gate to the departure runway queue. To enable real-time decision making the computational time of the push back time window optimization is critical and is analyzed throughout.

Being First Matters: Topographical Representational Similarity Analysis of ERP Signals Reveals Separate Networks for Audiovisual Temporal Binding Depending on the Leading Sense.

PubMed

Cecere, Roberto; Gross, Joachim; Willis, Ashleigh; Thut, Gregor

2017-05-24

In multisensory integration, processing in one sensory modality is enhanced by complementary information from other modalities. Intersensory timing is crucial in this process because only inputs reaching the brain within a restricted temporal window are perceptually bound. Previous research in the audiovisual field has investigated various features of the temporal binding window, revealing asymmetries in its size and plasticity depending on the leading input: auditory-visual (AV) or visual-auditory (VA). Here, we tested whether separate neuronal mechanisms underlie this AV-VA dichotomy in humans. We recorded high-density EEG while participants performed an audiovisual simultaneity judgment task including various AV-VA asynchronies and unisensory control conditions (visual-only, auditory-only) and tested whether AV and VA processing generate different patterns of brain activity. After isolating the multisensory components of AV-VA event-related potentials (ERPs) from the sum of their unisensory constituents, we ran a time-resolved topographical representational similarity analysis (tRSA) comparing the AV and VA ERP maps. Spatial cross-correlation matrices were built from real data to index the similarity between the AV and VA maps at each time point (500 ms window after stimulus) and then correlated with two alternative similarity model matrices: AV maps = VA maps versus AV maps ≠ VA maps The tRSA results favored the AV maps ≠ VA maps model across all time points, suggesting that audiovisual temporal binding (indexed by synchrony perception) engages different neural pathways depending on the leading sense. The existence of such dual route supports recent theoretical accounts proposing that multiple binding mechanisms are implemented in the brain to accommodate different information parsing strategies in auditory and visual sensory systems. SIGNIFICANCE STATEMENT Intersensory timing is a crucial aspect of multisensory integration, determining whether and how inputs in one modality enhance stimulus processing in another modality. Our research demonstrates that evaluating synchrony of auditory-leading (AV) versus visual-leading (VA) audiovisual stimulus pairs is characterized by two distinct patterns of brain activity. This suggests that audiovisual integration is not a unitary process and that different binding mechanisms are recruited in the brain based on the leading sense. These mechanisms may be relevant for supporting different classes of multisensory operations, for example, auditory enhancement of visual attention (AV) and visual enhancement of auditory speech (VA). Copyright © 2017 Cecere et al.

Being First Matters: Topographical Representational Similarity Analysis of ERP Signals Reveals Separate Networks for Audiovisual Temporal Binding Depending on the Leading Sense

PubMed Central

2017-01-01

In multisensory integration, processing in one sensory modality is enhanced by complementary information from other modalities. Intersensory timing is crucial in this process because only inputs reaching the brain within a restricted temporal window are perceptually bound. Previous research in the audiovisual field has investigated various features of the temporal binding window, revealing asymmetries in its size and plasticity depending on the leading input: auditory–visual (AV) or visual–auditory (VA). Here, we tested whether separate neuronal mechanisms underlie this AV–VA dichotomy in humans. We recorded high-density EEG while participants performed an audiovisual simultaneity judgment task including various AV–VA asynchronies and unisensory control conditions (visual-only, auditory-only) and tested whether AV and VA processing generate different patterns of brain activity. After isolating the multisensory components of AV–VA event-related potentials (ERPs) from the sum of their unisensory constituents, we ran a time-resolved topographical representational similarity analysis (tRSA) comparing the AV and VA ERP maps. Spatial cross-correlation matrices were built from real data to index the similarity between the AV and VA maps at each time point (500 ms window after stimulus) and then correlated with two alternative similarity model matrices: AVmaps = VAmaps versus AVmaps ≠ VAmaps. The tRSA results favored the AVmaps ≠ VAmaps model across all time points, suggesting that audiovisual temporal binding (indexed by synchrony perception) engages different neural pathways depending on the leading sense. The existence of such dual route supports recent theoretical accounts proposing that multiple binding mechanisms are implemented in the brain to accommodate different information parsing strategies in auditory and visual sensory systems. SIGNIFICANCE STATEMENT Intersensory timing is a crucial aspect of multisensory integration, determining whether and how inputs in one modality enhance stimulus processing in another modality. Our research demonstrates that evaluating synchrony of auditory-leading (AV) versus visual-leading (VA) audiovisual stimulus pairs is characterized by two distinct patterns of brain activity. This suggests that audiovisual integration is not a unitary process and that different binding mechanisms are recruited in the brain based on the leading sense. These mechanisms may be relevant for supporting different classes of multisensory operations, for example, auditory enhancement of visual attention (AV) and visual enhancement of auditory speech (VA). PMID:28450537

Search for repeating events at the plate interface in the seismic sequence of the 2014 Mw8.1 Iquique earthquake, Chile

NASA Astrophysics Data System (ADS)

Kummerow, Joern; Asch, Guenter; Sens-Schönfelder, Christoph; Schurr, Bernd; Tilmann, Frederik; Shapiro, Serge A.

2017-04-01

The 2014 Mw8.1 Iquique earthquake occurred along a segment of the northern Chile- southern Peru seismic gap which had not ruptured for more than 100 years. A specific feature of this event is the observation of prominent foreshock clusters with successively increasing seismic moment releases starting several months before the main shock (e.g., Schurr et al., 2014). The entire seismic sequence, including also the aftershock seismicity, was monitored exceptionally well by the Integrated Plate Boundary Observatory Chile (IPOC). Here, we present results from a systematic, long-term search for repeating seismic events along the plate interface in the source region of the 1 April 2014 (Mw8.1) Iquique main shock. Repeating earthquakes are widely assumed to indicate recurrent ruptures on the same fault patch and to accommodate aseismic slip in the creeping portions around the seismic patch. According to this concept, the analysis of repeating events and of their temporal behaviour provides a tool to estimate the amount of creep. We use the IPOC and two additional local seismic networks and select recorded waveforms of several hundreds of located earthquakes within the foreshock and aftershock series as template events. Waveforms are windowed around the P and S phases and bandpass-filtered for different frequency bands. Window starts are defined by manually revised P onset times. We then run a newly implemented correlation detector on the resampled, continuous seismic data to find highly similar waveforms for each template event. Repeating earthquakes are finally identified by a combination of estimated source dimensions, high waveform similarity and precise relative relocations of the events within each multiplet group. The analysis of the spatial and temporal patterns of the detected repeating earthquake sequences allows to test the proposed idea of progressive unlocking of the plate boundary before the Iquique main shock.

Spatiotemporal Patterns of Contact Across the Rat Vibrissal Array During Exploratory Behavior

PubMed Central

Hobbs, Jennifer A.; Towal, R. Blythe; Hartmann, Mitra J. Z.

2016-01-01

The rat vibrissal system is an important model for the study of somatosensation, but the small size and rapid speed of the vibrissae have precluded measuring precise vibrissal-object contact sequences during behavior. We used a laser light sheet to quantify, with 1 ms resolution, the spatiotemporal structure of whisker-surface contact as five naïve rats freely explored a flat, vertical glass wall. Consistent with previous work, we show that the whisk cycle cannot be uniquely defined because different whiskers often move asynchronously, but that quasi-periodic (~8 Hz) variations in head velocity represent a distinct temporal feature on which to lock analysis. Around times of minimum head velocity, whiskers protract to make contact with the surface, and then sustain contact with the surface for extended durations (~25–60 ms) before detaching. This behavior results in discrete temporal windows in which large numbers of whiskers are in contact with the surface. These “sustained collective contact intervals” (SCCIs) were observed on 100% of whisks for all five rats. The overall spatiotemporal structure of the SCCIs can be qualitatively predicted based on information about head pose and the average whisk cycle. In contrast, precise sequences of whisker-surface contact depend on detailed head and whisker kinematics. Sequences of vibrissal contact were highly variable, equally likely to propagate in all directions across the array. Somewhat more structure was found when sequences of contacts were examined on a row-wise basis. In striking contrast to the high variability associated with contact sequences, a consistent feature of each SCCI was that the contact locations of the whiskers on the glass converged and moved more slowly on the sheet. Together, these findings lead us to propose that the rat uses a strategy of “windowed sampling” to extract an object's spatial features: specifically, the rat spatially integrates quasi-static mechanical signals across whiskers during the period of sustained contact, resembling an “enclosing” haptic procedure. PMID:26778990

Static and Dynamic Compaction of CL-20 Powders

NASA Astrophysics Data System (ADS)

Cooper, Marcia; Brundage, Aaron; Dudley, Evan

2009-06-01

Hexanitrohexaazaisowurtzitane (CL-20) powders were compacted under quasi-static and dynamic loading conditions. A uniaxial compression apparatus quasi-statically compressed the powders to 90% theoretical maximum density with applied stresses up to 0.5 GPa. Dynamic compaction measurements using low-density pressings (62-70% theoretical maximum density) were obtained in a single-stage gas gun at impact velocities between 0.17-0.70 km/s. Experiments were conducted in a reverse ballistic arrangement in which the CL-20 ladened projectile impacted a target consisting of an aluminized window. VISAR-measured particle velocities at the explosive-window interface determined the shock Hugoniot states for pressures up to 0.9 GPa. The powder compaction behavior is found to be stiffer under dynamic loading than under quasi-static loading. Additional gas gun tests were conducted in which the low-density CL-20 pressings were confined within a target cup by the aluminized window. This arrangement enabled temporal measurement of the transmitted wave profiles in which elastic wave precursors were observed.

Micromirror-based manipulation of synchrotron x-ray beams

NASA Astrophysics Data System (ADS)

Walko, D. A.; Chen, Pice; Jung, I. W.; Lopez, D.; Schwartz, C. P.; Shenoy, G. K.; Wang, Jin

2017-08-01

Synchrotron beamlines typically use macroscopic, quasi-static optics to manipulate x-ray beams. We present the use of dynamic microelectromechanical systems-based optics (MEMS) to temporally modulate synchrotron x-ray beams. We demonstrate this concept using single-crystal torsional MEMS micromirrors oscillating at frequencies of 75 kHz. Such a MEMS micromirror, with lateral dimensions of a few hundred micrometers, can interact with x rays by operating in grazing-incidence reflection geometry; x rays are deflected only when an x-ray pulse is incident on the rotating micromirror under appropriate conditions, i.e., at an angle less than the critical angle for reflectivity. The time window for such deflections depends on the frequency and amplitude of the MEMS rotation. We demonstrate that reflection geometry can produce a time window of a few microseconds. We further demonstrate that MEMS optics can isolate x rays from a selected synchrotron bunch or group of bunches. With ray-trace simulations we explain the currently achievable time windows and suggest a path toward improvements.

Inter-Comparison of GOES-8 Imager and Sounder Skin Temperature Retrievals

NASA Technical Reports Server (NTRS)

Haines, Stephanie L.; Suggs, Ronnie J.; Jedlovec, Gary J.; Arnold, James E. (Technical Monitor)

2001-01-01

Skin temperature (ST) retrievals derived from geostationary satellite observations have both high temporal and spatial resolutions and are therefore useful for applications such as assimilation into mesoscale forecast models, nowcasting, and diagnostic studies. Our retrieval method uses a Physical Split Window technique requiring at least two channels within the longwave infrared window. On current GOES satellites, including GOES-11, there are two Imager channels within the required spectral interval. However, beginning with the GOES-M satellite the 12-um channel will be removed, leaving only one longwave channel. The Sounder instrument will continue to have three channels within the longwave window, and therefore ST retrievals will be derived from Sounder measurements. This research compares retrievals from the two instruments and evaluates the effects of the spatial resolution and sensor calibration differences on the retrievals. Both Imager and Sounder retrievals are compared to ground-truth data to evaluate the overall accuracy of the technique. An analysis of GOES-8 and GOES-11 intercomparisons is also presented.

Longitudinal variability in Jupiter's zonal winds derived from multi-wavelength HST observations

NASA Astrophysics Data System (ADS)

Johnson, Perianne E.; Morales-Juberías, Raúl; Simon, Amy; Gaulme, Patrick; Wong, Michael H.; Cosentino, Richard G.

2018-06-01

Multi-wavelength Hubble Space Telescope (HST) images of Jupiter from the Outer Planets Atmospheres Legacy (OPAL) and Wide Field Coverage for Juno (WFCJ) programs in 2015, 2016, and 2017 are used to derive wind profiles as a function of latitude and longitude. Wind profiles are typically zonally averaged to reduce measurement uncertainties. However, doing this destroys any variations of the zonal-component of winds in the longitudinal direction. Here, we present the results derived from using a "sliding-window" correlation method. This method adds longitudinal specificity, and allows for the detection of spatial variations in the zonal winds. Spatial variations are identified in two jets: 1 at 17 ° N, the location of a prominent westward jet, and the other at 7 ° S, the location of the chevrons. Temporal and spatial variations at the 24°N jet and the 5-μm hot spots are also examined.

0.5-keV Soft X-ray attosecond continua

PubMed Central

Teichmann, S. M.; Silva, F.; Cousin, S. L.; Hemmer, M.; Biegert, J.

2016-01-01

Attosecond light pulses in the extreme ultraviolet have drawn a great deal of attention due to their ability to interrogate electronic dynamics in real time. Nevertheless, to follow charge dynamics and excitations in materials, element selectivity is a prerequisite, which demands such pulses in the soft X-ray region, above 200 eV, to simultaneously cover several fundamental absorption edges of the constituents of the materials. Here, we experimentally demonstrate the exploitation of a transient phase matching regime to generate carrier envelope controlled soft X-ray supercontinua with pulse energies up to 2.9±0.1 pJ and a flux of (7.3±0.1) × 107 photons per second across the entire water window and attosecond pulses with 13 as transform limit. Our results herald attosecond science at the fundamental absorption edges of matter by bridging the gap between ultrafast temporal resolution and element specific probing. PMID:27167525

SPICODYN: A Toolbox for the Analysis of Neuronal Network Dynamics and Connectivity from Multi-Site Spike Signal Recordings.

PubMed

Pastore, Vito Paolo; Godjoski, Aleksandar; Martinoia, Sergio; Massobrio, Paolo

2018-01-01

We implemented an automated and efficient open-source software for the analysis of multi-site neuronal spike signals. The software package, named SPICODYN, has been developed as a standalone windows GUI application, using C# programming language with Microsoft Visual Studio based on .NET framework 4.5 development environment. Accepted input data formats are HDF5, level 5 MAT and text files, containing recorded or generated time series spike signals data. SPICODYN processes such electrophysiological signals focusing on: spiking and bursting dynamics and functional-effective connectivity analysis. In particular, for inferring network connectivity, a new implementation of the transfer entropy method is presented dealing with multiple time delays (temporal extension) and with multiple binary patterns (high order extension). SPICODYN is specifically tailored to process data coming from different Multi-Electrode Arrays setups, guarantying, in those specific cases, automated processing. The optimized implementation of the Delayed Transfer Entropy and the High-Order Transfer Entropy algorithms, allows performing accurate and rapid analysis on multiple spike trains from thousands of electrodes.

Studying dynamic processes in liquids by TEM/STEM/DTEM

NASA Astrophysics Data System (ADS)

Abellan, Patricia; Evans, James; Woehl, Taylor; Jungjohann, Katherine; Parent, Lucas; Arslan, Ilke; Ristenpart, William; Browning, Nigel; Mater. Sci. Group Team; Microsc. Group Team; Catal. Sci. Group Collaboration; Ristenpart Res. Group Collaboration

2013-03-01

In order to study dynamic phenomena such as corrosion or catalysis, extreme environmental conditions must be reproduced around the specimen - these include high-temperatures, high-pressures, specific oxidizing/reducing atmospheres or a liquid environment. The use of environmental stages specifically designed to fit in any transmission electron microscope (TEM) allows us to apply the distinct capabilities of each instrument to study dynamic processes. Localized gas/fluid conditions are created around the sample and separated from the high vacuum inside the microscope using hermetically sealed windowed-cells. Advanced capabilities of these techniques include spatial resolutions of ~1 Angstrom or better in aberration corrected instruments or temporal resolutions in the microsecond-nanosecond range in a dynamic TEM (DTEM). Here, unique qualities of the DTEM that benefit the in-situ experiments with gas/fluid environmental cells will be discussed. We also present our results with a liquid stage allowing atomic resolution imaging of nanomaterials in a colloidal suspension, core EEL spectra acquisition, continuous flow, controlled growth of nanocrystals and systematic calibration of the effect of the electron dose on silver nuclei formation.

Multimodal lexical processing in auditory cortex is literacy skill dependent.

PubMed

McNorgan, Chris; Awati, Neha; Desroches, Amy S; Booth, James R

2014-09-01

Literacy is a uniquely human cross-modal cognitive process wherein visual orthographic representations become associated with auditory phonological representations through experience. Developmental studies provide insight into how experience-dependent changes in brain organization influence phonological processing as a function of literacy. Previous investigations show a synchrony-dependent influence of letter presentation on individual phoneme processing in superior temporal sulcus; others demonstrate recruitment of primary and associative auditory cortex during cross-modal processing. We sought to determine whether brain regions supporting phonological processing of larger lexical units (monosyllabic words) over larger time windows is sensitive to cross-modal information, and whether such effects are literacy dependent. Twenty-two children (age 8-14 years) made rhyming judgments for sequentially presented word and pseudoword pairs presented either unimodally (auditory- or visual-only) or cross-modally (audiovisual). Regression analyses examined the relationship between literacy and congruency effects (overlapping orthography and phonology vs. overlapping phonology-only). We extend previous findings by showing that higher literacy is correlated with greater congruency effects in auditory cortex (i.e., planum temporale) only for cross-modal processing. These skill effects were specific to known words and occurred over a large time window, suggesting that multimodal integration in posterior auditory cortex is critical for fluent reading. © The Author 2013. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice.

PubMed

Liu, Karen J; Arron, Joseph R; Stankunas, Kryn; Crabtree, Gerald R; Longaker, Michael T

2007-03-01

Glycogen synthase kinase-3beta (GSK-3beta) has integral roles in a variety of biological processes, including development, diabetes, and the progression of Alzheimer's disease. As such, a thorough understanding of GSK-3beta function will have a broad impact on human biology and therapeutics. Because GSK-3beta interacts with many different pathways, its specific developmental roles remain unclear. We have discovered a genetic requirement for GSK-3beta in midline development. Homozygous null mice display cleft palate, incomplete fusion of the ribs at the midline and bifid sternum as well as delayed sternal ossification. Using a chemically regulated allele of GSK-3beta (ref. 6), we have defined requirements for GSK-3beta activity during discrete temporal windows in palatogenesis and skeletogenesis. The rapamycin-dependent allele of GSK-3beta produces GSK-3beta fused to a tag, FRB* (FKBP/rapamycin binding), resulting in a rapidly destabilized chimaeric protein. In the absence of drug, GSK-3beta(FRB)*(/FRB)* mutants appear phenotypically identical to GSK-3beta-/- mutants. In the presence of drug, GSK-3betaFRB* is rapidly stabilized, restoring protein levels and activity. Using this system, mutant phenotypes were rescued by restoring endogenous GSK-3beta activity during two distinct periods in gestation. This technology provides a powerful tool for defining windows of protein function during development.

Optogenetics through windows on the brain in the nonhuman primate

PubMed Central

Ruiz, Octavio; Lustig, Brian R.; Nassi, Jonathan J.; Cetin, Ali; Reynolds, John H.; Albright, Thomas D.; Callaway, Edward M.; Stoner, Gene R.

2013-01-01

Optogenetics combines optics and genetics to control neuronal activity with cell-type specificity and millisecond temporal precision. Its use in model organisms such as rodents, Drosophila, and Caenorhabditis elegans is now well-established. However, application of this technology in nonhuman primates (NHPs) has been slow to develop. One key challenge has been the delivery of viruses and light to the brain through the thick dura mater of NHPs, which can only be penetrated with large-diameter devices that damage the brain. The opacity of the NHP dura prevents visualization of the underlying cortex, limiting the spatial precision of virus injections, electrophysiological recordings, and photostimulation. Here, we describe a new optogenetics approach in which the native dura is replaced with an optically transparent artificial dura. This artificial dura can be penetrated with fine glass micropipettes, enabling precisely targeted injections of virus into brain tissue with minimal damage to cortex. The expression of optogenetic agents can be monitored visually over time. Most critically, this optical window permits targeted, noninvasive photostimulation and concomitant measurements of neuronal activity via intrinsic signal imaging and electrophysiological recordings. We present results from both anesthetized-paralyzed (optical imaging) and awake-behaving NHPs (electrophysiology). The improvements over current methods made possible by the artificial dura should enable the widespread use of optogenetic tools in NHP research, a key step toward the development of therapies for neuropsychiatric and neurological diseases in humans. PMID:23761700

A chronometric exploration of high-resolution 'sensitive TMS masking' effects on subjective and objective measures of vision.

PubMed

de Graaf, Tom A; Herring, Jim; Sack, Alexander T

2011-03-01

Transcranial magnetic stimulation (TMS) can induce masking by interfering with ongoing neural activity in early visual cortex. Previous work has explored the chronometry of occipital involvement in vision by using single pulses of TMS with high temporal resolution. However, conventionally TMS intensities have been high and the only measure used to evaluate masking was objective in nature. Recent studies have begun to incorporate subjective measures of vision, alongside objective ones. The current study goes beyond previous work in two regards. First, we explored both objective vision (an orientation discrimination task) and subjective vision (a stimulus visibility rating on a four-point scale), across a wide range of time windows with high temporal resolution. Second, we used a very sensitive TMS-masking paradigm: stimulation was at relatively low TMS intensities, with a figure-8 coil, and the small stimulus was difficult to discriminate already at baseline level. We hypothesized that this should increase the effective temporal resolution of our paradigm. Perhaps for this reason, we are able to report a rather interesting masking curve. Within the classical-masking time window, previously reported to encompass broad SOAs anywhere between 60 and 120 ms, we report not one, but at least two dips in objective performance, with no masking in-between. The subjective measure of vision did not mirror this pattern. These preliminary data from our exploratory design suggest that, with sensitive TMS masking, we might be able to reveal visual processes in early visual cortex previously unreported.

Temporal differentiation of pH-dependent capacitive current from dopamine.

PubMed

Yoshimi, Kenji; Weitemier, Adam

2014-09-02

Voltammetric recording of dopamine (DA) with fast-scan cyclic voltammetry (FSCV) on carbon fiber microelectrodes have been widely used, because of its high sensitivity to dopamine. However, since an electric double layer on a carbon fiber surface in a physiological ionic solution behaves as a capacitor, fast voltage manipulation in FSCV induces large capacitive current. The faradic current from oxidation/reduction of target chemicals must be extracted from this large background current. It is known that ionic shifts, including H(+), influence this capacitance, and pH shift can cause confounding influences on the FSCV recordings within a wide range of voltage. Besides FSCV with a triangular waveform, we have been using rectangular pulse voltammetry (RPV) for dopamine detection in the brain. In this method, the onset of a single pulse causes a large capacitive current, but unlike FSCV, the capacitive current is restricted to a narrow temporal window of just after pulse onset (<5 ms). In contrast, the peak of faradic current from dopamine oxidation occurs after a delay of more than a few milliseconds. Taking advantage of the temporal difference, we show that RPV could distinguish dopamine from pH shifts clearly and easily. In addition, the early onset current was useful to evaluate pH shifts. The narrow voltage window of our RPV pulse allowed a clear differentiation of dopamine and serotonin (5-HT), as we have shown previously. Additional recording with RPV, alongside FSCV, would improve identification of chemicals such as dopamine, pH, and 5-HT.

Intraglomerular inhibition shapes the strength and temporal structure of glomerular output

PubMed Central

Shao, Zuoyi; Puche, Adam C.; Liu, Shaolin

2012-01-01

Odor signals are transmitted to the olfactory bulb by olfactory nerve (ON) synapses onto mitral/tufted cells (MCs) and external tufted cells (ETCs). ETCs, in turn, provide feedforward excitatory input to MCs. MC and ETCs are also regulated by inhibition: intraglomerular and interglomerular inhibitory circuits act at MC and ETC apical dendrites; granule cells (GCs) inhibit MC lateral dendrites via the MC→GC→MC circuit. We investigated the contribution of intraglomerular inhibition to MC and ETCs responses to ON input. ON input evokes initial excitation followed by early, strongly summating inhibitory postsynaptic currents (IPSCs) in MCs; this is followed by prolonged, intermittent IPSCs. The N-methyl-d-aspartate receptor antagonist dl-amino-5-phosphovaleric acid, known to suppress GABA release by GCs, reduced late IPSCs but had no effect on early IPSCs. In contrast, selective intraglomerular block of GABAA receptors eliminated all early IPSCs and caused a 5-fold increase in ON-evoked MC spiking and a 10-fold increase in response duration. ETCs also receive intraglomerular inhibition; blockade of inhibition doubled ETC spike responses. By reducing ETC excitatory drive and directly inhibiting MCs, intraglomerular inhibition is a key factor shaping the strength and temporal structure of MC responses to sensory input. Sensory input generates an intraglomerular excitation-inhibition sequence that limits MC spike output to a brief temporal window. Glomerular circuits may dynamically regulate this input-output window to optimize MC encoding across sniff-sampled inputs. PMID:22592311

Intraglomerular inhibition shapes the strength and temporal structure of glomerular output.

PubMed

Shao, Zuoyi; Puche, Adam C; Liu, Shaolin; Shipley, Michael T

2012-08-01

Odor signals are transmitted to the olfactory bulb by olfactory nerve (ON) synapses onto mitral/tufted cells (MCs) and external tufted cells (ETCs). ETCs, in turn, provide feedforward excitatory input to MCs. MC and ETCs are also regulated by inhibition: intraglomerular and interglomerular inhibitory circuits act at MC and ETC apical dendrites; granule cells (GCs) inhibit MC lateral dendrites via the MC→GC→MC circuit. We investigated the contribution of intraglomerular inhibition to MC and ETCs responses to ON input. ON input evokes initial excitation followed by early, strongly summating inhibitory postsynaptic currents (IPSCs) in MCs; this is followed by prolonged, intermittent IPSCs. The N-methyl-d-aspartate receptor antagonist dl-amino-5-phosphovaleric acid, known to suppress GABA release by GCs, reduced late IPSCs but had no effect on early IPSCs. In contrast, selective intraglomerular block of GABA(A) receptors eliminated all early IPSCs and caused a 5-fold increase in ON-evoked MC spiking and a 10-fold increase in response duration. ETCs also receive intraglomerular inhibition; blockade of inhibition doubled ETC spike responses. By reducing ETC excitatory drive and directly inhibiting MCs, intraglomerular inhibition is a key factor shaping the strength and temporal structure of MC responses to sensory input. Sensory input generates an intraglomerular excitation-inhibition sequence that limits MC spike output to a brief temporal window. Glomerular circuits may dynamically regulate this input-output window to optimize MC encoding across sniff-sampled inputs.

Temporal Characterization of Aircraft Noise Sources

NASA Technical Reports Server (NTRS)

Grosveld, Ferdinand W.; Sullivan, Brenda M.; Rizzi, Stephen A.

2004-01-01

Current aircraft source noise prediction tools yield time-independent frequency spectra as functions of directivity angle. Realistic evaluation and human assessment of aircraft fly-over noise require the temporal characteristics of the noise signature. The purpose of the current study is to analyze empirical data from broadband jet and tonal fan noise sources and to provide the temporal information required for prediction-based synthesis. Noise sources included a one-tenth-scale engine exhaust nozzle and a one-fifth scale scale turbofan engine. A methodology was developed to characterize the low frequency fluctuations employing the Short Time Fourier Transform in a MATLAB computing environment. It was shown that a trade-off is necessary between frequency and time resolution in the acoustic spectrogram. The procedure requires careful evaluation and selection of the data analysis parameters, including the data sampling frequency, Fourier Transform window size, associated time period and frequency resolution, and time period window overlap. Low frequency fluctuations were applied to the synthesis of broadband noise with the resulting records sounding virtually indistinguishable from the measured data in initial subjective evaluations. Amplitude fluctuations of blade passage frequency (BPF) harmonics were successfully characterized for conditions equivalent to take-off and approach. Data demonstrated that the fifth harmonic of the BPF varied more in frequency than the BPF itself and exhibited larger amplitude fluctuations over the duration of the time record. Frequency fluctuations were found to be not perceptible in the current characterization of tonal components.

The Role of Oscillatory Phase in Determining the Temporal Organization of Perception: Evidence from Sensory Entrainment.

PubMed

Ronconi, Luca; Melcher, David

2017-11-01

Recent behavioral, neuroimaging, and neurophysiological studies have renewed the idea that the information processing within different temporal windows is linked to the phase and/or frequency of the ongoing oscillations, predominantly in the theta/alpha band (∼4-7 and 8-12 Hz, respectively). However, being correlational in nature, this evidence might reflect a nonfunctional byproduct rather than having a causal role. A more direct link can be shown with methods that manipulate oscillatory activity. Here, we used audiovisual entrainment at different frequencies in the prestimulus period of a temporal integration/segregation task. We hypothesized that entrainment would align ongoing oscillations and drive them toward the stimulation frequency. To reveal behavioral oscillations in temporal perception after the entrainment, we sampled the segregation/integration performance densely in time. In Experiment 1, two groups of human participants (both males and females) received stimulation either at the lower or the upper boundary of the alpha band (∼8.5 vs 11.5 Hz). For both entrainment frequencies, we found a phase alignment of the perceptual oscillation across subjects, but with two different power spectra that peaked near the entrainment frequency. These results were confirmed when perceptual oscillations were characterized in the time domain with sinusoidal fittings. In Experiment 2, we replicated the findings in a within-subject design, extending the results for frequencies in the theta (∼6.5 Hz), but not in the beta (∼15 Hz), range. Overall, these findings show that temporal segregation can be modified by sensory entrainment, providing evidence for a critical role of ongoing oscillations in the temporal organization of perception. SIGNIFICANCE STATEMENT The continuous flow of sensory input is not processed in an analog fashion, but rather is grouped by the perceptual system over time. Recent studies pinpointed the phase and/or frequency of the neural oscillations in the theta/alpha band (∼4-12 Hz) as possible mechanisms underlying temporal windows in perception. Here, we combined two innovative methodologies to provide more direct support for this evidence. We used sensory entrainment to align neural oscillations to different frequencies and then characterized the resultant perceptual oscillation with a temporal dense sampling of the integration/segregation performance. Our results provide the first evidence that the frequency of temporal segregation can be modified by sensory entrainment, supporting a critical role of ongoing oscillations in the integration/segregation of information over time. Copyright © 2017 Ronconi and Melcher.

Wavelet-based clustering of resting state MRI data in the rat.

PubMed

Medda, Alessio; Hoffmann, Lukas; Magnuson, Matthew; Thompson, Garth; Pan, Wen-Ju; Keilholz, Shella

2016-01-01

While functional connectivity has typically been calculated over the entire length of the scan (5-10min), interest has been growing in dynamic analysis methods that can detect changes in connectivity on the order of cognitive processes (seconds). Previous work with sliding window correlation has shown that changes in functional connectivity can be observed on these time scales in the awake human and in anesthetized animals. This exciting advance creates a need for improved approaches to characterize dynamic functional networks in the brain. Previous studies were performed using sliding window analysis on regions of interest defined based on anatomy or obtained from traditional steady-state analysis methods. The parcellation of the brain may therefore be suboptimal, and the characteristics of the time-varying connectivity between regions are dependent upon the length of the sliding window chosen. This manuscript describes an algorithm based on wavelet decomposition that allows data-driven clustering of voxels into functional regions based on temporal and spectral properties. Previous work has shown that different networks have characteristic frequency fingerprints, and the use of wavelets ensures that both the frequency and the timing of the BOLD fluctuations are considered during the clustering process. The method was applied to resting state data acquired from anesthetized rats, and the resulting clusters agreed well with known anatomical areas. Clusters were highly reproducible across subjects. Wavelet cross-correlation values between clusters from a single scan were significantly higher than the values from randomly matched clusters that shared no temporal information, indicating that wavelet-based analysis is sensitive to the relationship between areas. Copyright © 2015 Elsevier Inc. All rights reserved.

Restraint Stress Inhibits Mouse Implantation: Temporal Window and the Involvement of HB-EGF, Estrogen and Progesterone

PubMed Central

Yuan, Hong-Jie; Liang, Bo; Zheng, Liang-Liang; Liu, Yu-Xiang; Luo, Ming-Jiu; Tan, Jing-He

2013-01-01

It is known that psychological stress affects reproduction in women, but it is unknown whether the effect is by impairing implantation. Although studies suggest that long periods of auditory or restraint stress may inhibit implantation in rats and mice, the exact stage of pregnancy at which stress impairs implantation is unclear. Furthermore, whether stress impairs implantation by decreasing the heparin-binding epidermal growth factor-like growth factor (HB-EGF), estrogen and/or progesterone and whether by acting on embryos or on the uterus need further investigations. In this study, a 24-h restraint stress was initiated at 15:30 of day 3 (regimen 1) or at 07:30 (regimen 2) or 15:30 of day 4 (regimen 3) of pregnancy (vaginal plug  =  day 1) to observe effects of restraint stress applied at different peri-implantation stages on implantation. Among the three regimens, whereas regimens 1 and 3 affected neither term pregnancy nor litter size, regimen 2 reduced both. Further observations indicated that regimen 2 of restraint stress also delayed blastocyst hatching and the attachment reaction, decreased serum concentrations of progesterone and estradiol, and down regulated the expression of HB-EGF in both the endometrium and blastocysts. Taken together, the results suggested that restraint stress inhibited mouse implantation in a temporal window-dependent manner and by impairing blastocyst activation and hatching and uterine receptivity via down-regulating HB-EGF, estrogen and progesterone. Thus, the stress applied within the implantation window impaired implantation by acting on both embryos and the uterus. PMID:24244689

A technical assessment of the market for wood windows in Japanese post and beam construction

Treesearch

J. Roos; P. Boardman; I. Eastin

2004-01-01

This research was conducted to develop a better understanding of the problems and opportunities confronting U.S. wood window manufacturers in the post and beam segment of the Japanese residential construction industry. The specific objectives of this research were to (1) provide a description of the Japanese market for wood windows; (2) survey Japanese builders...

Analysis of all-optical temporal integrator employing phased-shifted DFB-SOA.

PubMed

Jia, Xin-Hong; Ji, Xiao-Ling; Xu, Cong; Wang, Zi-Nan; Zhang, Wei-Li

2014-11-17

All-optical temporal integrator using phase-shifted distributed-feedback semiconductor optical amplifier (DFB-SOA) is investigated. The influences of system parameters on its energy transmittance and integration error are explored in detail. The numerical analysis shows that, enhanced energy transmittance and integration time window can be simultaneously achieved by increased injected current in the vicinity of lasing threshold. We find that the range of input pulse-width with lower integration error is highly sensitive to the injected optical power, due to gain saturation and induced detuning deviation mechanism. The initial frequency detuning should also be carefully chosen to suppress the integration deviation with ideal waveform output.

A pipeline of spatio-temporal filtering for predicting the laterality of self-initiated fine movements from single trial readiness potentials.

PubMed

Zeid, Elias Abou; Sereshkeh, Alborz Rezazadeh; Chau, Tom

2016-12-01

In recent years, the readiness potential (RP), a type of pre-movement neural activity, has been investigated for asynchronous electroencephalogram (EEG)-based brain-computer interfaces (BCIs). Since the RP is attenuated for involuntary movements, a BCI driven by RP alone could facilitate intentional control amid a plethora of unintentional movements. Previous studies have attempted single trial classification of RP via spatial and temporal filtering methods, or by combining the RP with event-related desynchronization. However, RP feature extraction remains challenging due to the slow non-oscillatory nature of the potential, its variability among participants and the inherent noise in EEG signals. Here, we propose a participant-specific, individually optimized pipeline of spatio-temporal filtering (PSTF) to improve RP feature extraction for laterality prediction. PSTF applies band-pass filtering on RP signals, followed by Fisher criterion spatial filtering to maximize class separation, and finally temporal window averaging for feature dimension reduction. Optimal parameters are simultaneously found by cross-validation for each participant. Using EEG data from 14 participants performing self-initiated left or right key presses as well as two benchmark BCI datasets, we compared the performance of PSTF to two popular methods: common spatial subspace decomposition, and adaptive spatio-temporal filtering. On the BCI benchmark data sets, PSTF performed comparably to both existing methods. With the key press EEG data, PSTF extracted more discriminative features, thereby leading to more accurate (74.99% average accuracy) predictions of RP laterality than that achievable with existing methods. Naturalistic and volitional interaction with the world is an important capacity that is lost with traditional system-paced BCIs. We demonstrated a significant improvement in fine movement laterality prediction from RP features alone. Our work supports further study of RP-based BCI for intuitive asynchronous control of the environment, such as augmentative communication or wheelchair navigation.

A pipeline of spatio-temporal filtering for predicting the laterality of self-initiated fine movements from single trial readiness potentials

NASA Astrophysics Data System (ADS)

Abou Zeid, Elias; Rezazadeh Sereshkeh, Alborz; Chau, Tom

2016-12-01

Objective. In recent years, the readiness potential (RP), a type of pre-movement neural activity, has been investigated for asynchronous electroencephalogram (EEG)-based brain-computer interfaces (BCIs). Since the RP is attenuated for involuntary movements, a BCI driven by RP alone could facilitate intentional control amid a plethora of unintentional movements. Previous studies have attempted single trial classification of RP via spatial and temporal filtering methods, or by combining the RP with event-related desynchronization. However, RP feature extraction remains challenging due to the slow non-oscillatory nature of the potential, its variability among participants and the inherent noise in EEG signals. Here, we propose a participant-specific, individually optimized pipeline of spatio-temporal filtering (PSTF) to improve RP feature extraction for laterality prediction. Approach. PSTF applies band-pass filtering on RP signals, followed by Fisher criterion spatial filtering to maximize class separation, and finally temporal window averaging for feature dimension reduction. Optimal parameters are simultaneously found by cross-validation for each participant. Using EEG data from 14 participants performing self-initiated left or right key presses as well as two benchmark BCI datasets, we compared the performance of PSTF to two popular methods: common spatial subspace decomposition, and adaptive spatio-temporal filtering. Main results. On the BCI benchmark data sets, PSTF performed comparably to both existing methods. With the key press EEG data, PSTF extracted more discriminative features, thereby leading to more accurate (74.99% average accuracy) predictions of RP laterality than that achievable with existing methods. Significance. Naturalistic and volitional interaction with the world is an important capacity that is lost with traditional system-paced BCIs. We demonstrated a significant improvement in fine movement laterality prediction from RP features alone. Our work supports further study of RP-based BCI for intuitive asynchronous control of the environment, such as augmentative communication or wheelchair navigation.

Assessing the spatial implications of interactions among strategic forest management options using a Windows-based harvest simulator.

Treesearch

Eric J. Gustafson; Luke V. Rasmussen

2002-01-01

Forest management planners must develop strategies to produce timber in ways that do not compromise ecological integrity or sustainability. These strategies often involve modifications to the spatial and temporal scheduling of harvest activities, and these strategies may interact in unexpected ways. We used a timber harvest simulator (HARVEST 6.0) to determine the...

First results of ground-based LWIR hyperspectral imaging remote gas detection

NASA Astrophysics Data System (ADS)

Zheng, Wei-jian; Lei, Zheng-gang; Yu, Chun-chao; Wang, Hai-yang; Fu, Yan-peng; Liao, Ning-fang; Su, Jun-hong

2014-11-01

The new progress of ground-based long-wave infrared remote sensing is presented. The LWIR hyperspectral imaging by using the windowing spatial and temporal modulation Fourier spectroscopy, and the results of outdoor ether gas detection, verify the features of LWIR hyperspectral imaging remote sensing and technical approach. It provides a new technical means for ground-based gas remote sensing.

Lagged kernel machine regression for identifying time windows of susceptibility to exposures of complex mixtures.

PubMed

Liu, Shelley H; Bobb, Jennifer F; Lee, Kyu Ha; Gennings, Chris; Claus Henn, Birgit; Bellinger, David; Austin, Christine; Schnaas, Lourdes; Tellez-Rojo, Martha M; Hu, Howard; Wright, Robert O; Arora, Manish; Coull, Brent A

2018-07-01

The impact of neurotoxic chemical mixtures on children's health is a critical public health concern. It is well known that during early life, toxic exposures may impact cognitive function during critical time intervals of increased vulnerability, known as windows of susceptibility. Knowledge on time windows of susceptibility can help inform treatment and prevention strategies, as chemical mixtures may affect a developmental process that is operating at a specific life phase. There are several statistical challenges in estimating the health effects of time-varying exposures to multi-pollutant mixtures, such as: multi-collinearity among the exposures both within time points and across time points, and complex exposure-response relationships. To address these concerns, we develop a flexible statistical method, called lagged kernel machine regression (LKMR). LKMR identifies critical exposure windows of chemical mixtures, and accounts for complex non-linear and non-additive effects of the mixture at any given exposure window. Specifically, LKMR estimates how the effects of a mixture of exposures change with the exposure time window using a Bayesian formulation of a grouped, fused lasso penalty within a kernel machine regression (KMR) framework. A simulation study demonstrates the performance of LKMR under realistic exposure-response scenarios, and demonstrates large gains over approaches that consider each time window separately, particularly when serial correlation among the time-varying exposures is high. Furthermore, LKMR demonstrates gains over another approach that inputs all time-specific chemical concentrations together into a single KMR. We apply LKMR to estimate associations between neurodevelopment and metal mixtures in Early Life Exposures in Mexico and Neurotoxicology, a prospective cohort study of child health in Mexico City.

Timing-dependent LTP and LTD in mouse primary visual cortex following different visual deprivation models

PubMed Central

Chen, Xia; Fu, Junhong; Cheng, Wenbo; Song, Desheng; Qu, Xiaolei; Yang, Zhuo; Zhao, Kanxing

2017-01-01

Visual deprivation during the critical period induces long-lasting changes in cortical circuitry by adaptively modifying neuro-transmission and synaptic connectivity at synapses. Spike timing-dependent plasticity (STDP) is considered a strong candidate for experience-dependent changes. However, the visual deprivation forms that affect timing-dependent long-term potentiation(LTP) and long-term depression(LTD) remain unclear. Here, we demonstrated the temporal window changes of tLTP and tLTD, elicited by coincidental pre- and post-synaptic firing, following different modes of 6-day visual deprivation. Markedly broader temporal windows were found in robust tLTP and tLTD in the V1M of the deprived visual cortex in mice after 6-day MD and DE. The underlying mechanism for the changes seen with visual deprivation in juvenile mice using 6 days of dark exposure or monocular lid suture involves an increased fraction of NR2b-containing NMDAR and the consequent prolongation of NMDAR-mediated response duration. Moreover, a decrease in NR2A protein expression at the synapse is attributable to the reduction of the NR2A/2B ratio in the deprived cortex. PMID:28520739

Comparisons of transient evoked otoacoustic emissions using chirp and click stimuli

PubMed Central

Keefe, Douglas H.; Feeney, M. Patrick; Hunter, Lisa L.; Fitzpatrick, Denis F.

2016-01-01

Transient-evoked otoacoustic emission (TEOAE) responses (0.7–8 kHz) were measured in normal-hearing adult ears using click stimuli and chirps whose local frequency increased or decreased linearly with time over the stimulus duration. Chirp stimuli were created by allpass filtering a click with relatively constant incident pressure level over frequency. Chirp TEOAEs were analyzed as a nonlinear residual signal by inverse allpass filtering each chirp response into an equivalent click response. Multi-window spectral and temporal averaging reduced noise levels compared to a single-window average. Mean TEOAE levels using click and chirp stimuli were similar with respect to their standard errors in adult ears. TEOAE group delay, group spread, instantaneous frequency, and instantaneous bandwidth were similar overall for chirp and click conditions, except for small differences showing nonlinear interactions differing across stimulus conditions. These results support the theory of a similar generation mechanism on the basilar membrane for both click and chirp conditions based on coherent reflection within the tonotopic region. TEOAE temporal fine structure was invariant across changes in stimulus level, which is analogous to the intensity invariance of click-evoked basilar-membrane displacement data. PMID:27914441

Optimal Design for Hetero-Associative Memory: Hippocampal CA1 Phase Response Curve and Spike-Timing-Dependent Plasticity

PubMed Central

Miyata, Ryota; Ota, Keisuke; Aonishi, Toru

2013-01-01

Recently reported experimental findings suggest that the hippocampal CA1 network stores spatio-temporal spike patterns and retrieves temporally reversed and spread-out patterns. In this paper, we explore the idea that the properties of the neural interactions and the synaptic plasticity rule in the CA1 network enable it to function as a hetero-associative memory recalling such reversed and spread-out spike patterns. In line with Lengyel’s speculation (Lengyel et al., 2005), we firstly derive optimally designed spike-timing-dependent plasticity (STDP) rules that are matched to neural interactions formalized in terms of phase response curves (PRCs) for performing the hetero-associative memory function. By maximizing object functions formulated in terms of mutual information for evaluating memory retrieval performance, we search for STDP window functions that are optimal for retrieval of normal and doubly spread-out patterns under the constraint that the PRCs are those of CA1 pyramidal neurons. The system, which can retrieve normal and doubly spread-out patterns, can also retrieve reversed patterns with the same quality. Finally, we demonstrate that purposely designed STDP window functions qualitatively conform to typical ones found in CA1 pyramidal neurons. PMID:24204822

An improvement of drought monitoring through the use of a multivariate magnitude index

NASA Astrophysics Data System (ADS)

Real-Rangel, R. A.; Alcocer-Yamanaka, V. H.; Pedrozo-Acuña, A.; Breña-Naranjo, J. A.; Ocón-Gutiérrez, A. R.

2017-12-01

In drought monitoring activities it is widely acknowledged that the severity of an event is determined in relation to monthly values of univariate indices of one or more hydrological variables. Normally, these indices are estimated using temporal windows from 1 to 12 months or more to aggregate the effects of deficits in the variable of interest. However, the use of these temporal windows may lead to a misperception of both, the drought event intensity and the timing of its occurrence. In this context, this work presents the implementation of a trivariate drought magnitude index, considering key hydrological variables (e.g., precipitation, soil moisture and runoff) using for this the framework of the Multivariate Standardized Drought Index (MSDI). Despite the popularity and simplicity of the concept of drought magnitude for standardized drought indices, its implementation in drought monitoring and early warning systems has not been reported. This approach has been tested for operational purposes in the recently launched Multivariate Drought Monitor of Mexico (MOSEMM) and the results shows that the inclusion of a Magnitude index facilitates the drought detection and, thus, improves the decision making process for emergency managers.

Comparisons of transient evoked otoacoustic emissions using chirp and click stimuli.

PubMed

Keefe, Douglas H; Feeney, M Patrick; Hunter, Lisa L; Fitzpatrick, Denis F

2016-09-01

Transient-evoked otoacoustic emission (TEOAE) responses (0.7-8 kHz) were measured in normal-hearing adult ears using click stimuli and chirps whose local frequency increased or decreased linearly with time over the stimulus duration. Chirp stimuli were created by allpass filtering a click with relatively constant incident pressure level over frequency. Chirp TEOAEs were analyzed as a nonlinear residual signal by inverse allpass filtering each chirp response into an equivalent click response. Multi-window spectral and temporal averaging reduced noise levels compared to a single-window average. Mean TEOAE levels using click and chirp stimuli were similar with respect to their standard errors in adult ears. TEOAE group delay, group spread, instantaneous frequency, and instantaneous bandwidth were similar overall for chirp and click conditions, except for small differences showing nonlinear interactions differing across stimulus conditions. These results support the theory of a similar generation mechanism on the basilar membrane for both click and chirp conditions based on coherent reflection within the tonotopic region. TEOAE temporal fine structure was invariant across changes in stimulus level, which is analogous to the intensity invariance of click-evoked basilar-membrane displacement data.

Exposure Classification and Temporal Variability in Urinary Bisphenol A Concentrations among Couples in Utah--The HOPE Study.

PubMed

Cox, Kyley J; Porucznik, Christina A; Anderson, David J; Brozek, Eric M; Szczotka, Kathryn M; Bailey, Nicole M; Wilkins, Diana G; Stanford, Joseph B

2016-04-01

Bisphenol A (BPA) is an endocrine disruptor and potential reproductive toxicant, but results of epidemiologic studies have been mixed and have been criticized for inadequate exposure assessment that often relies on a single measurement. Our goal was to describe the distribution of BPA concentrations in serial urinary specimens, assess temporal variability, and provide estimates of exposure classification when randomly selected samples are used to predict average exposure. We collected and analyzed 2,614 urine specimens from 83 Utah couples beginning in 2012. Female participants collected daily first-morning urine specimens during one to two menstrual cycles and male partners collected specimens during the woman's fertile window for each cycle. We measured urinary BPA concentrations and calculated geometric means (GM) for each cycle, characterized the distribution of observed values and temporal variability using intraclass correlation coefficients, and performed surrogate category analyses to determine how well repeat samples could classify exposure. The GM urine BPA concentration was 2.78 ng/mL among males and 2.44 ng/mL among females. BPA had a high degree of variability among both males (ICC = 0.18; 95% CI: 0.11, 0.26) and females (ICC = 0.11; 95% CI: 0.08, 0.16). Based on our more stringent surrogate category analysis, to reach proportions ≥ 0.80 for sensitivity, specificity, and positive predictive value (PPV) among females, 6 and 10 repeat samples for the high and low tertiles, respectively, were required. For the medium tertile, specificity reached 0.87 with 10 repeat samples, but even with 11 samples, sensitivity and PPV did not exceed 0.36. Five repeat samples, among males, yielded sensitivity and PPV values ≥ 0.75 for the high and low tertiles, but, similar to females, classification for the medium tertile was less accurate. Repeated urinary specimens are required to characterize typical BPA exposure. Cox KJ, Porucznik CA, Anderson DJ, Brozek EM, Szczotka KM, Bailey NM, Wilkins DG, Stanford JB. 2016. Exposure classification and temporal variability in urinary bisphenol A concentrations among couples in Utah-the HOPE study. Environ Health Perspect 124:498-506; http://dx.doi.org/10.1289/ehp.1509752.

Data in support of energy performance of double-glazed windows.

PubMed

Shakouri, Mahmoud; Banihashemi, Saeed

2016-06-01

This paper provides the data used in a research project to propose a new simplified windows rating system based on saved annual energy ("Developing an empirical predictive energy-rating model for windows by using Artificial Neural Network" (Shakouri Hassanabadi and Banihashemi Namini, 2012) [1], "Climatic, parametric and non-parametric analysis of energy performance of double-glazed windows in different climates" (Banihashemi et al., 2015) [2]). A full factorial simulation study was conducted to evaluate the performance of 26 different types of windows in a four-story residential building. In order to generalize the results, the selected windows were tested in four climates of cold, tropical, temperate, and hot and arid; and four different main orientations of North, West, South and East. The accompanied datasets include the annual saved cooling and heating energy in different climates and orientations by using the selected windows. Moreover, a complete dataset is provided that includes the specifications of 26 windows, climate data, month, and orientation of the window. This dataset can be used to make predictive models for energy efficiency assessment of double glazed windows.

Sensitivity and Specificity of Emergency Physicians and Trainees for Identifying Internally Concealed Drug Packages on Abdominal Computed Tomography Scan: Do Lung Windows Improve Accuracy?

PubMed

Asha, Stephen Edward; Cooke, Andrew

2015-09-01

Suspected body packers may be brought to emergency departments (EDs) close to international airports for abdominal computed tomography (CT) scanning. Senior emergency clinicians may be asked to interpret these CT scans. Missing concealed drug packages have important clinical and forensic implications. The accuracy of emergency clinician interpretation of abdominal CT scans for concealed drugs is not known. Limited evidence suggests that accuracy for identification of concealed packages can be increased by viewing CT images on "lung window" settings. To determine the accuracy of senior emergency clinicians in interpreting abdominal CT scans for concealed drugs, and to determine if this accuracy was improved by viewing scans on both abdominal and lung window settings. Emergency clinicians blinded to all patient identifiers and the radiology report interpreted CT scans of suspected body packers using standard abdominal window settings and then with the addition of lung window settings. The reference standard was the radiologist's report. Fifty-five emergency clinicians reported 235 CT scans. The sensitivity, specificity, and accuracy of interpretation using abdominal windows was 89.9% (95% confidence interval [CI] 83.0-94.7), 81.9% (95% CI 73.7-88.4), and 86.0% (95% CI 81.5-90.4), respectively, and with both window settings was 94.1% (95% CI 88.3-97.6), 76.7% (95% CI 68.0-84.1), 85.5% (95% CI 81.0-90.0), respectively. Diagnostic accuracy was similar regardless of the clinician's experience. Interrater reliability was moderate (kappa 0.46). The accuracy of interpretation of abdominal CT scans performed for the purpose of detecting concealed drug packages by emergency clinicians is not high enough to safely discharge these patients from the ED. The use of lung windows improved sensitivity, but at the expense of specificity. Crown Copyright © 2015. Published by Elsevier Inc. All rights reserved.

Temporal Ventriloquism Reveals Intact Audiovisual Temporal Integration in Amblyopia.

PubMed

Richards, Michael D; Goltz, Herbert C; Wong, Agnes M F

2018-02-01

We have shown previously that amblyopia involves impaired detection of asynchrony between auditory and visual events. To distinguish whether this impairment represents a defect in temporal integration or nonintegrative multisensory processing (e.g., cross-modal matching), we used the temporal ventriloquism effect in which visual temporal order judgment (TOJ) is normally enhanced by a lagging auditory click. Participants with amblyopia (n = 9) and normally sighted controls (n = 9) performed a visual TOJ task. Pairs of clicks accompanied the two lights such that the first click preceded the first light, or second click lagged the second light by 100, 200, or 450 ms. Baseline audiovisual synchrony and visual-only conditions also were tested. Within both groups, just noticeable differences for the visual TOJ task were significantly reduced compared with baseline in the 100- and 200-ms click lag conditions. Within the amblyopia group, poorer stereo acuity and poorer visual acuity in the amblyopic eye were significantly associated with greater enhancement in visual TOJ performance in the 200-ms click lag condition. Audiovisual temporal integration is intact in amblyopia, as indicated by perceptual enhancement in the temporal ventriloquism effect. Furthermore, poorer stereo acuity and poorer visual acuity in the amblyopic eye are associated with a widened temporal binding window for the effect. These findings suggest that previously reported abnormalities in audiovisual multisensory processing may result from impaired cross-modal matching rather than a diminished capacity for temporal audiovisual integration.

Dynamic functional connectivity and its behavioral correlates beyond vigilance.

PubMed

Patanaik, Amiya; Tandi, Jesisca; Ong, Ju Lynn; Wang, Chenhao; Zhou, Juan; Chee, Michael W L

2018-04-25

Fluctuations in resting-state functional connectivity and global signal have been found to correspond with vigilance fluctuations, but their associations with other behavioral measures are unclear. We evaluated 52 healthy adolescents after a week of adequate sleep followed by five nights of sleep restriction to unmask inter-individual differences in cognition and mood. Resting state scans obtained at baseline only, analyzed using sliding window analysis, consistently yielded two polar dynamic functional connectivity states (DCSs) corresponding to previously reported 'low arousal' and 'high arousal' states. We found that the relative temporal preponderance of two dynamic connectivity states (DCS) in well-rested participants, indexed by a median split of participants, based on the relative time spent in these DCS, revealed highly significant group differences in vigilance at baseline and its decline following multiple nights of sleep restriction. Group differences in processing speed and working memory following manipulation but not at baseline suggest utility of DCS in predicting cognitive vulnerabilities unmasked by a stressor like sleep restriction. DCS temporal predominance was uninformative about mood and sleepiness speaking to specificity in its behavioral predictions. Global signal fluctuation provided information confined to vigilance. This appears to be related to head motion, which increases during periods of low arousal. Copyright © 2018. Published by Elsevier Inc.

Mapping of Human FOXP2 Enhancers Reveals Complex Regulation.

PubMed

Becker, Martin; Devanna, Paolo; Fisher, Simon E; Vernes, Sonja C

2018-01-01

Mutations of the FOXP2 gene cause a severe speech and language disorder, providing a molecular window into the neurobiology of language. Individuals with FOXP2 mutations have structural and functional alterations affecting brain circuits that overlap with sites of FOXP2 expression, including regions of the cortex, striatum, and cerebellum. FOXP2 displays complex patterns of expression in the brain, as well as in non-neuronal tissues, suggesting that sophisticated regulatory mechanisms control its spatio-temporal expression. However, to date, little is known about the regulation of FOXP2 or the genomic elements that control its expression. Using chromatin conformation capture (3C), we mapped the human FOXP2 locus to identify putative enhancer regions that engage in long-range interactions with the promoter of this gene. We demonstrate the ability of the identified enhancer regions to drive gene expression. We also show regulation of the FOXP2 promoter and enhancer regions by candidate regulators - FOXP family and TBR1 transcription factors. These data point to regulatory elements that may contribute to the temporal- or tissue-specific expression patterns of human FOXP2 . Understanding the upstream regulatory pathways controlling FOXP2 expression will bring new insight into the molecular networks contributing to human language and related disorders.

Mapping of Human FOXP2 Enhancers Reveals Complex Regulation

PubMed Central

Becker, Martin; Devanna, Paolo; Fisher, Simon E.; Vernes, Sonja C.

2018-01-01

Mutations of the FOXP2 gene cause a severe speech and language disorder, providing a molecular window into the neurobiology of language. Individuals with FOXP2 mutations have structural and functional alterations affecting brain circuits that overlap with sites of FOXP2 expression, including regions of the cortex, striatum, and cerebellum. FOXP2 displays complex patterns of expression in the brain, as well as in non-neuronal tissues, suggesting that sophisticated regulatory mechanisms control its spatio-temporal expression. However, to date, little is known about the regulation of FOXP2 or the genomic elements that control its expression. Using chromatin conformation capture (3C), we mapped the human FOXP2 locus to identify putative enhancer regions that engage in long-range interactions with the promoter of this gene. We demonstrate the ability of the identified enhancer regions to drive gene expression. We also show regulation of the FOXP2 promoter and enhancer regions by candidate regulators – FOXP family and TBR1 transcription factors. These data point to regulatory elements that may contribute to the temporal- or tissue-specific expression patterns of human FOXP2. Understanding the upstream regulatory pathways controlling FOXP2 expression will bring new insight into the molecular networks contributing to human language and related disorders. PMID:29515369

Brain hemodynamic activity during viewing and re-viewing of comedy movies explained by experienced humor

PubMed Central

Jääskeläinen, Iiro P.; Pajula, Juha; Tohka, Jussi; Lee, Hsin-Ju; Kuo, Wen-Jui; Lin, Fa-Hsuan

2016-01-01

Humor is crucial in human social interactions. To study the underlying neural processes, three comedy clips were shown twice to 20 volunteers during functional magnetic resonance imaging (fMRI). Inter-subject similarities in humor ratings, obtained immediately after fMRI, explained inter-subject correlation of hemodynamic activity in right frontal pole and in a number of other brain regions. General linear model analysis also indicated activity in right frontal pole, as well as in additional cortical areas and subcortically in striatum, explained by humorousness. The association of the right frontal pole with experienced humorousness is a novel finding, which might be related to humor unfolding over longer time scales in the movie clips. Specifically, frontal pole has been shown to exhibit longer temporal receptive windows than, e.g., sensory areas, which might have enabled processing of humor in the clips based on holding information and reinterpreting that in light of new information several (even tens of) seconds later. As another novel finding, medial and lateral prefrontal areas, frontal pole, posterior-inferior temporal areas, posterior parietal areas, posterior cingulate, striatal structures and amygdala showed reduced activity upon re-viewing of the clips, suggesting involvement in processing of humor related to novelty of the comedic events. PMID:27323928

LANGUAGE EXPERIENCE SHAPES PROCESSING OF PITCH RELEVANT INFORMATION IN THE HUMAN BRAINSTEM AND AUDITORY CORTEX: ELECTROPHYSIOLOGICAL EVIDENCE.

PubMed

Krishnan, Ananthanarayan; Gandour, Jackson T

2014-12-01

Pitch is a robust perceptual attribute that plays an important role in speech, language, and music. As such, it provides an analytic window to evaluate how neural activity relevant to pitch undergo transformation from early sensory to later cognitive stages of processing in a well coordinated hierarchical network that is subject to experience-dependent plasticity. We review recent evidence of language experience-dependent effects in pitch processing based on comparisons of native vs. nonnative speakers of a tonal language from electrophysiological recordings in the auditory brainstem and auditory cortex. We present evidence that shows enhanced representation of linguistically-relevant pitch dimensions or features at both the brainstem and cortical levels with a stimulus-dependent preferential activation of the right hemisphere in native speakers of a tone language. We argue that neural representation of pitch-relevant information in the brainstem and early sensory level processing in the auditory cortex is shaped by the perceptual salience of domain-specific features. While both stages of processing are shaped by language experience, neural representations are transformed and fundamentally different at each biological level of abstraction. The representation of pitch relevant information in the brainstem is more fine-grained spectrotemporally as it reflects sustained neural phase-locking to pitch relevant periodicities contained in the stimulus. In contrast, the cortical pitch relevant neural activity reflects primarily a series of transient temporal neural events synchronized to certain temporal attributes of the pitch contour. We argue that experience-dependent enhancement of pitch representation for Chinese listeners most likely reflects an interaction between higher-level cognitive processes and early sensory-level processing to improve representations of behaviorally-relevant features that contribute optimally to perception. It is our view that long-term experience shapes this adaptive process wherein the top-down connections provide selective gating of inputs to both cortical and subcortical structures to enhance neural responses to specific behaviorally-relevant attributes of the stimulus. A theoretical framework for a neural network is proposed involving coordination between local, feedforward, and feedback components that can account for experience-dependent enhancement of pitch representations at multiple levels of the auditory pathway. The ability to record brainstem and cortical pitch relevant responses concurrently may provide a new window to evaluate the online interplay between feedback, feedforward, and local intrinsic components in the hierarchical processing of pitch relevant information.

LANGUAGE EXPERIENCE SHAPES PROCESSING OF PITCH RELEVANT INFORMATION IN THE HUMAN BRAINSTEM AND AUDITORY CORTEX: ELECTROPHYSIOLOGICAL EVIDENCE

PubMed Central

Krishnan, Ananthanarayan; Gandour, Jackson T.

2015-01-01

Pitch is a robust perceptual attribute that plays an important role in speech, language, and music. As such, it provides an analytic window to evaluate how neural activity relevant to pitch undergo transformation from early sensory to later cognitive stages of processing in a well coordinated hierarchical network that is subject to experience-dependent plasticity. We review recent evidence of language experience-dependent effects in pitch processing based on comparisons of native vs. nonnative speakers of a tonal language from electrophysiological recordings in the auditory brainstem and auditory cortex. We present evidence that shows enhanced representation of linguistically-relevant pitch dimensions or features at both the brainstem and cortical levels with a stimulus-dependent preferential activation of the right hemisphere in native speakers of a tone language. We argue that neural representation of pitch-relevant information in the brainstem and early sensory level processing in the auditory cortex is shaped by the perceptual salience of domain-specific features. While both stages of processing are shaped by language experience, neural representations are transformed and fundamentally different at each biological level of abstraction. The representation of pitch relevant information in the brainstem is more fine-grained spectrotemporally as it reflects sustained neural phase-locking to pitch relevant periodicities contained in the stimulus. In contrast, the cortical pitch relevant neural activity reflects primarily a series of transient temporal neural events synchronized to certain temporal attributes of the pitch contour. We argue that experience-dependent enhancement of pitch representation for Chinese listeners most likely reflects an interaction between higher-level cognitive processes and early sensory-level processing to improve representations of behaviorally-relevant features that contribute optimally to perception. It is our view that long-term experience shapes this adaptive process wherein the top-down connections provide selective gating of inputs to both cortical and subcortical structures to enhance neural responses to specific behaviorally-relevant attributes of the stimulus. A theoretical framework for a neural network is proposed involving coordination between local, feedforward, and feedback components that can account for experience-dependent enhancement of pitch representations at multiple levels of the auditory pathway. The ability to record brainstem and cortical pitch relevant responses concurrently may provide a new window to evaluate the online interplay between feedback, feedforward, and local intrinsic components in the hierarchical processing of pitch relevant information. PMID:25838636

2000 survey of window manufacturers on the subject of switchable glass

NASA Astrophysics Data System (ADS)

LaPointe, Michael R.; Sottile, Gregory M.

2001-11-01

The results of a 2000 survey of United States window manufacturers on the subject of switchable glass are discussed. The areas covered in this paper include awareness of the overall product category of switchable glass and various types of switchable glass, attitudes toward specific features of switchable glass, expectations for manufacturer production of such products, expectations for market penetration rates among end-product consumers, levels of price sensitivity among window manufacturers regarding switchable glass, and expectations for the pace of new product development within the window industry over the next five years.

Detection and localization of change points in temporal networks with the aid of stochastic block models

NASA Astrophysics Data System (ADS)

De Ridder, Simon; Vandermarliere, Benjamin; Ryckebusch, Jan

2016-11-01

A framework based on generalized hierarchical random graphs (GHRGs) for the detection of change points in the structure of temporal networks has recently been developed by Peel and Clauset (2015 Proc. 29th AAAI Conf. on Artificial Intelligence). We build on this methodology and extend it to also include the versatile stochastic block models (SBMs) as a parametric family for reconstructing the empirical networks. We use five different techniques for change point detection on prototypical temporal networks, including empirical and synthetic ones. We find that none of the considered methods can consistently outperform the others when it comes to detecting and locating the expected change points in empirical temporal networks. With respect to the precision and the recall of the results of the change points, we find that the method based on a degree-corrected SBM has better recall properties than other dedicated methods, especially for sparse networks and smaller sliding time window widths.

It's about time: Presentation in honor of Ira Hirsh

NASA Astrophysics Data System (ADS)

Grant, Ken

2002-05-01

Over his long and illustrious career, Ira Hirsh has returned time and time again to his interest in the temporal aspects of pattern perception. Although Hirsh has studied and published articles and books pertaining to many aspects of the auditory system, such as sound conduction in the ear, cochlear mechanics, masking, auditory localization, psychoacoustic behavior in animals, speech perception, medical and audiological applications, coupling between psychophysics and physiology, and ecological acoustics, it is his work on auditory timing of simple and complex rhythmic patterns, the backbone of speech and music, that are at the heart of his more recent work. Here, we will focus on several aspects of temporal processing of simple and complex signals, both within and across sensory systems. Data will be reviewed on temporal order judgments of simple tones, and simultaneity judgments and intelligibility of unimodal and bimodal complex stimuli where stimulus components are presented either synchronously or asynchronously. Differences in the symmetry and shape of ``temporal windows'' derived from these data sets will be highlighted.

Renshaw cell interneuron specialization is controlled by a temporally restricted transcription factor program

PubMed Central

Stam, Floor J.; Hendricks, Timothy J.; Zhang, Jingming; Geiman, Eric J.; Francius, Cedric; Labosky, Patricia A.; Clotman, Frederic; Goulding, Martyn

2012-01-01

The spinal cord contains a diverse array of physiologically distinct interneuron cell types that subserve specialized roles in somatosensory perception and motor control. The mechanisms that generate these specialized interneuronal cell types from multipotential spinal progenitors are not known. In this study, we describe a temporally regulated transcriptional program that controls the differentiation of Renshaw cells (RCs), an anatomically and functionally discrete spinal interneuron subtype. We show that the selective activation of the Onecut transcription factors Oc1 and Oc2 during the first wave of V1 interneuron neurogenesis is a key step in the RC differentiation program. The development of RCs is additionally dependent on the forkhead transcription factor Foxd3, which is more broadly expressed in postmitotic V1 interneurons. Our demonstration that RCs are born, and activate Oc1 and Oc2 expression, in a narrow temporal window leads us to posit that neuronal diversity in the developing spinal cord is established by the composite actions of early spatial and temporal determinants. PMID:22115757

Ionic Liquids as Electrolytes for Electrochemical Double-Layer Capacitors: Structures that Optimize Specific Energy.

PubMed

Mousavi, Maral P S; Wilson, Benjamin E; Kashefolgheta, Sadra; Anderson, Evan L; He, Siyao; Bühlmann, Philippe; Stein, Andreas

2016-02-10

Key parameters that influence the specific energy of electrochemical double-layer capacitors (EDLCs) are the double-layer capacitance and the operating potential of the cell. The operating potential of the cell is generally limited by the electrochemical window of the electrolyte solution, that is, the range of applied voltages within which the electrolyte or solvent is not reduced or oxidized. Ionic liquids are of interest as electrolytes for EDLCs because they offer relatively wide potential windows. Here, we provide a systematic study of the influence of the physical properties of ionic liquid electrolytes on the electrochemical stability and electrochemical performance (double-layer capacitance, specific energy) of EDLCs that employ a mesoporous carbon model electrode with uniform, highly interconnected mesopores (3DOm carbon). Several ionic liquids with structurally diverse anions (tetrafluoroborate, trifluoromethanesulfonate, trifluoromethanesulfonimide) and cations (imidazolium, ammonium, pyridinium, piperidinium, and pyrrolidinium) were investigated. We show that the cation size has a significant effect on the electrolyte viscosity and conductivity, as well as the capacitance of EDLCs. Imidazolium- and pyridinium-based ionic liquids provide the highest cell capacitance, and ammonium-based ionic liquids offer potential windows much larger than imidazolium and pyridinium ionic liquids. Increasing the chain length of the alkyl substituents in 1-alkyl-3-methylimidazolium trifluoromethanesulfonimide does not widen the potential window of the ionic liquid. We identified the ionic liquids that maximize the specific energies of EDLCs through the combined effects of their potential windows and the double-layer capacitance. The highest specific energies are obtained with ionic liquid electrolytes that possess moderate electrochemical stability, small ionic volumes, low viscosity, and hence high conductivity, the best performing ionic liquid tested being 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide.

Temporal Response Properties of Accessory Olfactory Bulb Neurons: Limitations and Opportunities for Decoding.

PubMed

Yoles-Frenkel, Michal; Kahan, Anat; Ben-Shaul, Yoram

2018-05-23

The vomeronasal system (VNS) is a major vertebrate chemosensory system that functions in parallel to the main olfactory system (MOS). Despite many similarities, the two systems dramatically differ in the temporal domain. While MOS responses are governed by breathing and follow a subsecond temporal scale, VNS responses are uncoupled from breathing and evolve over seconds. This suggests that the contribution of response dynamics to stimulus information will differ between these systems. While temporal dynamics in the MOS are widely investigated, similar analyses in the accessory olfactory bulb (AOB) are lacking. Here, we have addressed this issue using controlled stimulus delivery to the vomeronasal organ of male and female mice. We first analyzed the temporal properties of AOB projection neurons and demonstrated that neurons display prolonged, variable, and neuron-specific characteristics. We then analyzed various decoding schemes using AOB population responses. We showed that compared with the simplest scheme (i.e., integration of spike counts over the entire response period), the division of this period into smaller temporal bins actually yields poorer decoding accuracy. However, optimal classification accuracy can be achieved well before the end of the response period by integrating spike counts within temporally defined windows. Since VNS stimulus uptake is variable, we analyzed decoding using limited information about stimulus uptake time, and showed that with enough neurons, such time-invariant decoding is feasible. Finally, we conducted simulations that demonstrated that, unlike the main olfactory bulb, the temporal features of AOB neurons disfavor decoding with high temporal accuracy, and, rather, support decoding without precise knowledge of stimulus uptake time. SIGNIFICANCE STATEMENT A key goal in sensory system research is to identify which metrics of neuronal activity are relevant for decoding stimulus features. Here, we describe the first systematic analysis of temporal coding in the vomeronasal system (VNS), a chemosensory system devoted to socially relevant cues. Compared with the main olfactory system, timescales of VNS function are inherently slower and variable. Using various analyses of real and simulated data, we show that the consideration of response times relative to stimulus uptake can aid the decoding of stimulus information from neuronal activity. However, response properties of accessory olfactory bulb neurons favor decoding schemes that do not rely on the precise timing of stimulus uptake. Such schemes are consistent with the variable nature of VNS stimulus uptake. Copyright © 2018 the authors 0270-6474/18/384957-20$15.00/0.

Thin and open vessel windows for intra-vital fluorescence imaging of murine cochlear blood flow

PubMed Central

Shi, Xiaorui; Zhang, Fei; Urdang, Zachary; Dai, Min; Neng, Lingling; Zhang, Jinhui; Chen, Songlin; Ramamoorthy, Sripriya; Nuttall, Alfred L.

2014-01-01

Normal microvessel structure and function in the cochlea is essential for maintaining the ionic and metabolic homeostasis required for hearing function. Abnormal cochlear microcirculation has long been considered an etiologic factor in hearing disorders. A better understanding of cochlear blood flow (CoBF) will enable more effective amelioration of hearing disorders that result from aberrant blood flow. However, establishing the direct relationship between CoBF and other cellular events in the lateral wall and response to physio-pathological stress remains a challenge due to the lack of feasible interrogation methods and difficulty in accessing the inner ear. Here we report on new methods for studying the CoBF in a mouse model using a thin or open vessel-window in combination with fluorescence intra-vital microscopy (IVM). An open vessel-window enables investigation of vascular cell biology and blood flow permeability, including pericyte (PC) contractility, bone marrow cell migration, and endothelial barrier leakage, in wild type and fluorescent protein-labeled transgenic mouse models with high spatial and temporal resolution. Alternatively, the thin vessel-window method minimizes disruption of the homeostatic balance in the lateral wall and enables study CoBF under relatively intact physiological conditions. A thin vessel-window method can also be used for time-based studies of physiological and pathological processes. Although the small size of the mouse cochlea makes surgery difficult, the methods are sufficiently developed for studying the structural and functional changes in CoBF under normal and pathological conditions. PMID:24780131

Measured Rattle Threshold of Residential House Windows

NASA Technical Reports Server (NTRS)

Sizov, Natalia; Schultz, Troy; Hobbs, Christopher; Klos, Jacob

2008-01-01

Window rattle is a common indoor noise effect in houses exposed to low frequency noise from such sources as railroads, blast noise and sonic boom. Human perception of rattle can be negative that is a motivating factor of the current research effort to study sonic boom induced window rattle. A rattle study has been conducted on residential houses containing windows of different construction at a variety of geographic locations within the United States. Windows in these houses were excited by a portable, high-powered loudspeaker and enclosure specifically designed to be mounted on the house exterior to cover an entire window. Window vibration was measured with accelerometers placed on different window components. Reference microphones were also placed inside the house and inside of the loudspeaker box. Swept sine excitation was used to identify the vibration threshold at which the response of the structure becomes non-linear and begins to rattle. Initial results from this study are presented and discussed. Future efforts will continue to explore the rattle occurrence in windows of residential houses exposed to sonic booms.

State-of-the-art software for window energy-efficiency rating and labeling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arasteh, D.; Finlayson, E.; Huang, J.

1998-07-01

Measuring the thermal performance of windows in typical residential buildings is an expensive proposition. Not only is laboratory testing expensive, but each window manufacturer typically offers hundreds of individual products, each of which has different thermal performance properties. With over a thousand window manufacturers nationally, a testing-based rating system would be prohibitively expensive to the industry and to consumers. Beginning in the early 1990s, simulation software began to be used as part of a national program for rating window U-values. The rating program has since been expanded to include Solar Hear Gain Coefficients and is now being extended to annualmore » energy performance. This paper describes four software packages available to the public from Lawrence Berkeley National Laboratory (LBNL). These software packages are used to evaluate window thermal performance: RESFEN (for evaluating annual energy costs), WINDOW (for calculating a product`s thermal performance properties), THERM (a preprocessor for WINDOW that determines two-dimensional heat-transfer effects), and Optics (a preprocessor for WINDOW`s glass database). Software not only offers a less expensive means than testing to evaluate window performance, it can also be used during the design process to help manufacturers produce windows that will meet target specifications. In addition, software can show small improvements in window performance that might not be detected in actual testing because of large uncertainties in test procedures.« less

Fast Color Grouping and Slow Color Inhibition: Evidence for Distinct Temporal Windows for Separate Processes in Preview Search

ERIC Educational Resources Information Center

Braithwaite, Jason J.; Humphreys, Glyn W.; Hulleman, Johan; Watson, Derrick G.

2007-01-01

The authors report 4 experiments that examined color grouping and negative carryover effects in preview search via a probe detection task (J. J. Braithwaite, G. W. Humphreys, & J. Hodsoll, 2003). In Experiment 1, there was evidence of a negative color carryover from the preview to new items, using both search and probe detection measures. There…

Land-use and land-cover change carbon emissions between 1901 and 2012 constrained by biomass observations

Treesearch

Wei Li; Philippe Ciais; Shushi Peng; Chao Yue; Yilong Wang; Martin Thurner; Sassan S. Saatchi; Almut Arneth; Valerio Avitabile; Nuno Carvalhais; Anna B. Harper; Etsushi Kato; Charles Koven; Yi Y. Liu; Julia E. M. S. Nabel; Yude Pan; Julia Pongratz; Benjamin Poulter; Thomas A. M. Pugh; Maurizio Santoro; Stephen Sitch; Benjamin D. Stocker; Nicolas Viovy; Andy Wiltshire; Rasoul Yousefpour; Sönke Zaehle

2017-01-01

The use of dynamic global vegetation models (DGVMs) to estimate CO2 emissions from land-use and land-cover change (LULCC) offers a new window to account for spatial and temporal details of emissions and for ecosystem processes affected by LULCC. One drawback of LULCC emissions from DGVMs, however, is lack of observation constraint. Here, we...

Processing Temporal Constraints and Some Implications for the Investigation of Second Language Sentence Processing and Acquisition. Commentary on Baggio

ERIC Educational Resources Information Center

Roberts, Leah

2008-01-01

Baggio presents the results of an event-related potential (ERP) study in which he examines the processing consequences of reading tense violations such as *"Afgelopen zondag lakt Vincent de kozijnen van zijn landhuis" (*"Last Sunday Vincent paints the window-frames of his country house"). The violation is arguably caused by a mismatch between the…

The geovisualisation window of the temporal and spatial variability for Volunteered Geographic Information activities

NASA Astrophysics Data System (ADS)

Medynska-Gulij, Beata; Myszczuk, Miłosz

2012-11-01

This study presents an attempt to design geographical visualisation tools that allow to tackle the immensity of spatial data provided by Volunteered Geographic Information (VGI), both in terms of temporal and spatial aspects. In accordance with the assumptions made at the conceptual stage, the final action was the implementation of the window entitled ‘Geovisualisation of the Panoramio.com Activities in District of Poznan 2011’ into the web browser. The concept has been based on a division of the geovisualisation window into three panels, of which the most important - in order to capture spatial variability - have statistical maps at the general level (dot map and choropleth map), while at the detailed level - a dot map on a topographic reference map or tourist map. For two ranges, temporal variability is presented by graphs, while a review of attributes of individual activities of the social website in question is set forward in the table panel. The element that visually interlinks all of the panels is the emphasised individual activity. Problemem podjetym w tych badaniach stało sie wykorzystanie metod z nurtu geograficznej wizualizacji do wskazania cech fenomenu VGI w zakresie zmiennosci czasowo-przestrzennej. Zgodnie z załozeniami poczynionymi w etapie koncepcyjnym finalnym działaniem stało sie zaimplementowanie do przegladarki internetowej okna pod tytułem: ”Geowizualizacja aktywnosci społecznosci Panoramio.com w powiecie poznanskim w 2011 roku”. Koncepcja została oparta na podziale okna geowizualizacji na trzy panele, z których najwazniejsze znaczenie dla uchwycenia zmiennosci przestrzennej na poziomie ogólnym ma kartogram, natomiast na poziomie szczegółowym mapa kropkowa wyswietlana na podkładzie mapy topograficznej lub turystycznej. Zmiennosc czasowa w dwóch zakresach prezentuja wykresy, a przeglad atrybutów poszczególnych aktywnosci prezentowanego portalu społecznosciowego zapewnia tabela. Elementem spajajacym wizualnie wszystkie panele jest wyeksponowana graficznie pojedyncza aktywnosc. Przetwarzanie danych odbyło sie w srodowisku open source, a technologia funkcjonowania aplikacji okna geowizualizacji bazowała na zastosowaniu asynchronicznych zapytan do serwera WWW oraz serwera baz danych co zapewnia sprawne "odswiezanie” poszczególnych paneli.

Determinants of black carbon, particle mass and number concentrations in London transport microenvironments

NASA Astrophysics Data System (ADS)

Rivas, Ioar; Kumar, Prashant; Hagen-Zanker, Alex; Andrade, Maria de Fatima; Slovic, Anne Dorothee; Pritchard, John P.; Geurs, Karst T.

2017-07-01

We investigated the determinants of personal exposure concentrations of commuters' to black carbon (BC), ultrafine particle number concentrations (PNC), and particulate matter (PM1, PM2.5 and PM10) in different travel modes. We quantified the contribution of key factors that explain the variation of the previous pollutants in four commuting routes in London, each covered by four transport modes (car, bus, walk and underground). Models were performed for each pollutant, separately to assess the effect of meteorology (wind speed) or ambient concentrations (with either high spatial or temporal resolution). Concentration variations were mainly explained by wind speed or ambient concentrations and to a lesser extent by route and period of the day. In multivariate models with wind speed, the wind speed was the common significant predictor for all the pollutants in the above-ground modes (i.e., car, bus, walk); and the only predictor variable for the PM fractions. Wind speed had the strongest effect on PM during the bus trips, with an increase in 1 m s-1 leading to a decrease in 2.25, 2.90 and 4.98 μg m-3 of PM1, PM2.5 and PM10, respectively. PM2.5 and PM10 concentrations in car trips were better explained by ambient concentrations with high temporal resolution although from a single monitoring station. On the other hand, ambient concentrations with high spatial coverage but lower temporal resolution predicted better the concentrations in bus trips, due to bus routes passing through streets with a high variability of traffic intensity. In the underground models, wind speed was not significant and line and type of windows on the train explained 42% of the variation of PNC and 90% of all PM fractions. Trains in the district line with openable windows had an increase in concentrations of 1 684 cm-3 for PNC and 40.69 μg m-3 for PM2.5 compared with trains that had non-openable windows. The results from this work can be used to target efforts to reduce personal exposures of London commuters.

Round Window Membrane Implantation with an Active Middle Ear Implant: A Study of the Effects on the Performance of Round Window Exposure and Transducer Tip Diameter in Human Cadaveric Temporal Bones

PubMed Central

Tringali, Stéphane; Koka, Kanthaiah; Deveze, Arnaud; Holland, N. Julian; Jenkins, Herman A.; Tollin, Daniel J.

2010-01-01

Objectives To assess the importance of 2 variables, transducer tip diameter and resection of the round window (RW) niche, affecting the optimization of the mechanical stimulation of the RW membrane with an active middle ear implant (AMEI). Materials and Methods: Ten temporal bones were prepared with combined atticotomy and facial recess approach to expose the RW. An AMEI stimulated the RW with 2 ball tip diameters (0.5 and 1.0 mm) before and after the resection of the bony rim of the RW niche. The RW drive performance, assessed by stapes velocities using laser Doppler velocimetry, was analyzed in 3 frequency ranges: low (0.25–1 kHz), medium (1–3 kHz) and high (3–8 kHz). Results Driving the RW produced mean peak stapes velocities (HEV) of 0.305 and 0.255 mm/s/V at 3.03 kHz, respectively, for the 1- and 0.5-mm tips, with the RW niche intact. Niche drilling increased the HEV to 0.73 and 0.832 mm/s/V for the 1- and 0.5-mm tips, respectively. The tip diameter produced no difference in output at low and medium frequencies; however, the 0.5-mm tip was 5 and 6 dB better than the 1-mm tip at high frequencies before and after niche drilling, respectively. Drilling the niche significantly improved the output by 4 dB at high frequencies for the 1-mm tip, and by 6 and 10 dB in the medium- and high-frequency ranges for the 0.5-mm tip. Conclusion The AMEI was able to successfully drive the RW membrane in cadaveric temporal bones using a classical facial recess approach. Stimulation of the RW membrane with an AMEI without drilling the niche is sufficient for successful hearing outputs. However, the resection of the bony rim of the RW niche significantly improved the RW stimulation at medium and higher frequencies. Drilling the niche enhances the exposure of the RW membrane and facilitates positioning the implant tip. PMID:20150727

Tutorial Guide: Computer-Aided Structural Modeling (CASM). Version 5.00

DTIC Science & Technology

1994-04-01

2-3 SITE-SPECIFIC DATA DIALOG WINDOW ................. 2-4 SAVING PROJECT DATA ....................... 2-7 PRINTING PROJECT CRITERIA DATA...you to the main CASM screen without saving changes. REGIONAL DATA DIALOG WINDOW The Regonal• Dtadlalg windtow contim ms0•twrmofogoik hronimdon.The...Information so that It will be Included In your hardcopy output. 3. Select OK to save your Regional Data entries. The Regional Data dalog window will disappear

Structure and Topology Dynamics of Hyper-Frequency Networks during Rest and Auditory Oddball Performance.

PubMed

Müller, Viktor; Perdikis, Dionysios; von Oertzen, Timo; Sleimen-Malkoun, Rita; Jirsa, Viktor; Lindenberger, Ulman

2016-01-01

Resting-state and task-related recordings are characterized by oscillatory brain activity and widely distributed networks of synchronized oscillatory circuits. Electroencephalographic recordings (EEG) were used to assess network structure and network dynamics during resting state with eyes open and closed, and auditory oddball performance through phase synchronization between EEG channels. For this assessment, we constructed a hyper-frequency network (HFN) based on within- and cross-frequency coupling (WFC and CFC, respectively) at 10 oscillation frequencies ranging between 2 and 20 Hz. We found that CFC generally differentiates between task conditions better than WFC. CFC was the highest during resting state with eyes open. Using a graph-theoretical approach (GTA), we found that HFNs possess small-world network (SWN) topology with a slight tendency to random network characteristics. Moreover, analysis of the temporal fluctuations of HFNs revealed specific network topology dynamics (NTD), i.e., temporal changes of different graph-theoretical measures such as strength, clustering coefficient, characteristic path length (CPL), local, and global efficiency determined for HFNs at different time windows. The different topology metrics showed significant differences between conditions in the mean and standard deviation of these metrics both across time and nodes. In addition, using an artificial neural network approach, we found stimulus-related dynamics that varied across the different network topology metrics. We conclude that functional connectivity dynamics (FCD), or NTD, which was found using the HFN approach during rest and stimulus processing, reflects temporal and topological changes in the functional organization and reorganization of neuronal cell assemblies.

Structure and Topology Dynamics of Hyper-Frequency Networks during Rest and Auditory Oddball Performance

PubMed Central

Müller, Viktor; Perdikis, Dionysios; von Oertzen, Timo; Sleimen-Malkoun, Rita; Jirsa, Viktor; Lindenberger, Ulman

2016-01-01

Resting-state and task-related recordings are characterized by oscillatory brain activity and widely distributed networks of synchronized oscillatory circuits. Electroencephalographic recordings (EEG) were used to assess network structure and network dynamics during resting state with eyes open and closed, and auditory oddball performance through phase synchronization between EEG channels. For this assessment, we constructed a hyper-frequency network (HFN) based on within- and cross-frequency coupling (WFC and CFC, respectively) at 10 oscillation frequencies ranging between 2 and 20 Hz. We found that CFC generally differentiates between task conditions better than WFC. CFC was the highest during resting state with eyes open. Using a graph-theoretical approach (GTA), we found that HFNs possess small-world network (SWN) topology with a slight tendency to random network characteristics. Moreover, analysis of the temporal fluctuations of HFNs revealed specific network topology dynamics (NTD), i.e., temporal changes of different graph-theoretical measures such as strength, clustering coefficient, characteristic path length (CPL), local, and global efficiency determined for HFNs at different time windows. The different topology metrics showed significant differences between conditions in the mean and standard deviation of these metrics both across time and nodes. In addition, using an artificial neural network approach, we found stimulus-related dynamics that varied across the different network topology metrics. We conclude that functional connectivity dynamics (FCD), or NTD, which was found using the HFN approach during rest and stimulus processing, reflects temporal and topological changes in the functional organization and reorganization of neuronal cell assemblies. PMID:27799906

Round and Oval Window Anatomic Variability: Its Implication for the Vibroplasty Technique.

PubMed

Mancheño, Marta; Aristegui, Miguel; Sañudo, Jose Ramon

2017-06-01

The objective of this study is to evaluate the anatomical variability of round and oval window regions and its relationship with their closest structures, to determine its implication on the fitting and stabilization of the middle ear implant Vibrant Soundbridge. Variations of the anatomy of round and oval window regions were assessed in a total of 85 human dissected temporal bones. Afterward, we evaluated the adaptation and subsequent stabilization of the floating mass transducer (FMT) of the Vibrant Soundbridge in 67 cases in round window (RW) and in 22 cases in oval window (OW), and the influence that the variability of the different anatomical features examined had on this stabilization. We also assessed access and surgeon's view of the RW niche through the facial recess approach. Stabilization of the FMT in the RW was achieved in 53 (79%) of the 67 cases; we found that the less favorable anatomical conditions for stabilization were: membrane smaller than 1.5 mm, presence of a high jugular bulb and a narrow or very narrow RW niche. Frequently, two or more of these conditions happened simultaneously. In seven cases (22%) access to the RW through facial recess approach did not allow positioning the FMT in place. OW stabilization succeeded in 18 (82%) of the 22 cases. Round and oval window vibroplasty are difficult surgical techniques. To place the FMT directly on the OW may be easier as we do not have to drill the niche. In both regions there are some anatomical conditions that hinder fitting the FMT and even make it impossible. Once fitted, the main problem is to achieve good stabilization of the device.

Non-ossicular signal transmission in human middle ears: Experimental assessment of the “acoustic route” with perforated tympanic membranes

PubMed Central

Voss, Susan E.; Rosowski, John J.; Merchant, Saumil N.; Peake, William T.

2008-01-01

Direct acoustic stimulation of the cochlea by the sound-pressure difference between the oval and round windows (called the “acoustic route”) has been thought to contribute to hearing in some pathological conditions, along with the normally dominant “ossicular route.” To determine the efficacy of this acoustic route and its constituent mechanisms in human ears, sound pressures were measured at three locations in cadaveric temporal bones [with intact and perforated tympanic membranes (TMs)]: (1) in the external ear canal lateral to the TM, PTM; (2) in the tympanic cavity lateral to the oval window, POW; and (3) near the round window, PRW. Sound transmission via the acoustic route is described by two concatenated processes: (1) coupling of sound pressure from ear canal to middle-ear cavity, HPCAV≡PCAV/PTM, where PCAV represents the middle-ear cavity pressure, and (2) sound-pressure difference between the windows, HWPD≡(POW−PRW)/PCAV. Results show that: HPCAV depends on perforation size but not perforation location; HWPD depends on neither perforation size nor location. The results (1) provide a description of the window pressures based on measurements, (2) refute the common otological view that TM perforation location affects the “relative phase of the pressures at the oval and round windows,” and (3) show with an intact ossicular chain that acoustic-route transmission is substantially below ossicular-route transmission except for low frequencies with large perforations. Thus, hearing loss from TM perforations results primarily from reduction in sound coupling via the ossicular route. Some features of the frequency dependence of HPCAV and HWPD can be interpreted in terms of a structure-based lumped-element acoustic model of the perforation and middle-ear cavities. PMID:17902851

Realigning thunder and lightning: temporal adaptation to spatiotemporally distant events.

PubMed

Navarra, Jordi; Fernández-Prieto, Irune; Garcia-Morera, Joel

2013-01-01

The brain is able to realign asynchronous signals that approximately coincide in both space and time. Given that many experience-based links between visual and auditory stimuli are established in the absence of spatiotemporal proximity, we investigated whether or not temporal realignment arises in these conditions. Participants received a 3-min exposure to visual and auditory stimuli that were separated by 706 ms and appeared either from the same (Experiment 1) or from different spatial positions (Experiment 2). A simultaneity judgment task (SJ) was administered right afterwards. Temporal realignment between vision and audition was observed, in both Experiment 1 and 2, when comparing the participants' SJs after this exposure phase with those obtained after a baseline exposure to audiovisual synchrony. However, this effect was present only when the visual stimuli preceded the auditory stimuli during the exposure to asynchrony. A similar pattern of results (temporal realignment after exposure to visual-leading asynchrony but not after exposure to auditory-leading asynchrony) was obtained using temporal order judgments (TOJs) instead of SJs (Experiment 3). Taken together, these results suggest that temporal recalibration still occurs for visual and auditory stimuli that fall clearly outside the so-called temporal window for multisensory integration and appear from different spatial positions. This temporal realignment may be modulated by long-term experience with the kind of asynchrony (vision-leading) that we most frequently encounter in the outside world (e.g., while perceiving distant events).

Polishing techniques for MEGARA pupil elements optics

NASA Astrophysics Data System (ADS)

Izazaga, R.; Carrasco, E.; Aguirre, D.; Salas, A.; Gil de Paz, A.; Gallego, J.; Iglesias, J.; Arroyo, J. M.; Hernández, M.; López, N.; López, V.; Quechol, J. T.; Salazar, M. F.; Carballo, C.; Cruz, E.; Arriaga, J.; De la Luz, J. A.; Huepa, A.; Jaimes, G. L.; Reyes, J.

2016-07-01

MEGARA (Multi-Espectrógrafo en GTC de Alta Resolución para Astronomía) is the new integral-field and multi-object optical spectrograph for the 10.4m Gran Telescopio Canarias.. It will offer RFWHM 6,000, 12,000 and 18,700 for the low- , mid- and high-resolution, respectively in the wavelength range 3650-9700Å. .The dispersive elements are volume phase holographic (VPH) gratings, sandwiched between two flat Fused Silica windows of high optical precision in large apertures. The design, based in VPHs in combination with Ohara PBM2Y prisms allows to keep the collimator and camera angle fixed. Seventy three optical elements are being built in Mexico at INAOE and CIO. For the low resolution modes, the VPHs windows specifications in irregularity is 1 fringe in 210mm x 170mm and 0.5 fringe in 190mm x 160mm. for a window thickness of 25 mm. For the medium and high resolution modes the irregularity specification is 2 fringes in 220mm x 180mm and 1 fringe in 205mm x 160mm, for a window thickness of 20mm. In this work we present a description of the polishing techniques developed at INAOE optical workshop to fabricate the 36 Fused Silica windows and 24 PBM2Y prisms that allows us to achieve such demanding specifications. We include the processes of mounting, cutting, blocking, polishing and testing.

Improved safety of retinal photocoagulation with a shaped beam and modulated pulse

NASA Astrophysics Data System (ADS)

Sramek, Christopher; Brown, Jefferson; Paulus, Yannis M.; Nomoto, Hiroyuki; Palanker, Daniel

2010-02-01

Shorter pulse durations help confine thermal damage during retinal photocoagulation, decrease treatment time and minimize pain. However, safe therapeutic window (the ratio of threshold powers for rupture and mild coagulation) decreases with shorter exposures. A ring-shaped beam enables safer photocoagulation than conventional beams by reducing the maximum temperature in the center of the spot. Similarly, a temporal pulse modulation decreasing its power over time improves safety by maintaining constant temperature for a significant portion of the pulse. Optimization of the beam and pulse shapes was performed using a computational model. In vivo experiments were performed to verify the predicted improvement. With each of these approaches, the pulse duration can be decreased by a factor of two, from 20 ms down to 10 ms while maintaining the same therapeutic window.

Whisking mechanics and active sensing

PubMed Central

Bush, Nicholas E; Solla, Sara A

2017-01-01

We describe recent advances in quantifying the three-dimensional (3D) geometry and mechanics of whisking. Careful delineation of relevant 3D reference frames reveals important geometric and mechanical distinctions between the localization problem (‘where’ is an object) and the feature extraction problem (‘what’ is an object). Head-centered and resting-whisker reference frames lend themselves to quantifying temporal and kinematic cues used for object localization. The whisking-centered reference frame lends itself to quantifying the contact mechanics likely associated with feature extraction. We offer the ‘windowed sampling’ hypothesis for active sensing: that rats can estimate an object’s spatial features by integrating mechanical information across whiskers during brief (25–60 ms) windows of ‘haptic enclosure’ with the whiskers, a motion that resembles a hand grasp. PMID:27632212

Whisking mechanics and active sensing.

PubMed

Bush, Nicholas E; Solla, Sara A; Hartmann, Mitra Jz

2016-10-01

We describe recent advances in quantifying the three-dimensional (3D) geometry and mechanics of whisking. Careful delineation of relevant 3D reference frames reveals important geometric and mechanical distinctions between the localization problem ('where' is an object) and the feature extraction problem ('what' is an object). Head-centered and resting-whisker reference frames lend themselves to quantifying temporal and kinematic cues used for object localization. The whisking-centered reference frame lends itself to quantifying the contact mechanics likely associated with feature extraction. We offer the 'windowed sampling' hypothesis for active sensing: that rats can estimate an object's spatial features by integrating mechanical information across whiskers during brief (25-60ms) windows of 'haptic enclosure' with the whiskers, a motion that resembles a hand grasp. Copyright © 2016. Published by Elsevier Ltd.

Optical Evaluation of DMDs with UV-Grade FS, Sapphire, MgF2 Windows and Reflectance of Bare Devices

NASA Technical Reports Server (NTRS)

Quijada, Manuel A.; Heap, Sara; Travinsky, Anton; Vorobiev, Dmitry; Ninkov, Zoran; Raisanen, Alan; Roberto, Massimo

2016-01-01

Digital Micro-mirror Devices (DMDs) have been identified as an alternative to microshutter arrays for space-based multi-object spectrometers (MOS). Specifically, the MOS at the heart of a proposed Galactic Evolution Spectroscopic Explorer (GESE) that uses the DMD as a reprogrammable slit mask. Unfortunately, the protective borosilicate windows limit the use of DMDs in the UV and IR regimes, where the glass has insufficient throughput. In this work, we present our efforts to replace standard DMD windows with custom windows made from UV-grade fused silica, Low Absorption Optical Sapphire (LAOS) and magnesium fluoride. We present reflectance measurements of the antireflection coated windows and a reflectance study of the DMDs active area (window removed). Furthermore, we investigated the long-term stability of the DMD reflectance and recoating device with fresh Al coatings.

Propagation of terahertz pulses in random media.

PubMed

Pearce, Jeremy; Jian, Zhongping; Mittleman, Daniel M

2004-02-15

We describe measurements of single-cycle terahertz pulse propagation in a random medium. The unique capabilities of terahertz time-domain spectroscopy permit the characterization of a multiply scattered field with unprecedented spatial and temporal resolution. With these results, we can develop a framework for understanding the statistics of broadband laser speckle. Also, the ability to extract information on the phase of the field opens up new possibilities for characterizing multiply scattered waves. We illustrate this with a simple example, which involves computing a time-windowed temporal correlation between fields measured at different spatial locations. This enables the identification of individual scattering events, and could lead to a new method for imaging in random media.

Micro-endoscopic ear anatomy of guinea pig applied to experimental surgery.

PubMed

Barros, Bruno Borges de Carvalho; Andrade, José Santos Cruz de; Garcia, Leandro Borborema; Pifaia, Gustavo Ribeiro; Cruz, Oswaldo Laércio Mendonça; Onishi, Ektor Tsuneo; Penido, Norma de Oliveira

2014-01-01

To describe topographic and endoscopic anatomy of guinea pig ear for development of surgical approaches in experimental studies. Experimental study. Eight adult guinea pigs (Cavia porcellus) were used in this study. Four animals were described through endoscopic view and four animals were used to describe topographic anatomy. The main structures of middle ear were well identified through endoscopy view: oval and round window, ossicles and vascular structures. Temporal bone position, landmarks and its relations to skull are perceived with topographic description. Topographic anatomic description allowed exposition of temporal bone relations for external surgical approaches. Alternatively, grooves and middle ear structures were identified and may be used to transcanal accesses.

Perinatal BPA exposure alters body weight and composition in a dose specific and sex specific manner: The addition of peripubertal exposure exacerbates adverse effects in female mice

PubMed Central

Rubin, Beverly S.; Paranjpe, Maneesha; DaFonte, Tracey; Schaeberle, Cheryl; Soto, Ana M.; Obin, Martin; Greenberg, Andrew S.

2017-01-01

Body weight (BW) and body composition were examined in CD-1 mice exposed perinatally or perinatally and peripubertally to 0, 0.25, 2.5, 25, or 250 μg BPA/kg BW/day. Our goal was to identify the BPA dose (s) and the exposure window(s) that increased BW and adiposity, and to assess potential sex differences in this response. Both perinatal exposure alone and perinatal plus peripubertal exposure to environmentally relevant levels of BPA resulted in lasting effects on body weight and body composition. The effects were dose specific and sex specific and were influenced by the precise window of BPA exposure. The addition of peripubertal BPA exposure following the initial perinatal exposure exacerbated adverse effects in the females but appeared to reduce differences in body weight and body composition between control and BPA exposed males. Some effects of BPA on body weight and body composition showed a non-linear dose response. PMID:27496714

Navigating the auditory scene: an expert role for the hippocampus.

PubMed

Teki, Sundeep; Kumar, Sukhbinder; von Kriegstein, Katharina; Stewart, Lauren; Lyness, C Rebecca; Moore, Brian C J; Capleton, Brian; Griffiths, Timothy D

2012-08-29

Over a typical career piano tuners spend tens of thousands of hours exploring a specialized acoustic environment. Tuning requires accurate perception and adjustment of beats in two-note chords that serve as a navigational device to move between points in previously learned acoustic scenes. It is a two-stage process that depends on the following: first, selective listening to beats within frequency windows, and, second, the subsequent use of those beats to navigate through a complex soundscape. The neuroanatomical substrates underlying brain specialization for such fundamental organization of sound scenes are unknown. Here, we demonstrate that professional piano tuners are significantly better than controls matched for age and musical ability on a psychophysical task simulating active listening to beats within frequency windows that is based on amplitude modulation rate discrimination. Tuners show a categorical increase in gray matter volume in the right frontal operculum and right superior temporal lobe. Tuners also show a striking enhancement of gray matter volume in the anterior hippocampus, parahippocampal gyrus, and superior temporal gyrus, and an increase in white matter volume in the posterior hippocampus as a function of years of tuning experience. The relationship with gray matter volume is sensitive to years of tuning experience and starting age but not actual age or level of musicality. Our findings support a role for a core set of regions in the hippocampus and superior temporal cortex in skilled exploration of complex sound scenes in which precise sound "templates" are encoded and consolidated into memory over time in an experience-dependent manner.

Temporal texture of associative encoding modulates recall processes.

PubMed

Tibon, Roni; Levy, Daniel A

2014-02-01

Binding aspects of an experience that are distributed over time is an important element of episodic memory. In the current study, we examined how the temporal complexity of an experience may govern the processes required for its retrieval. We recorded event-related potentials during episodic cued recall following pair associate learning of concurrently and sequentially presented object-picture pairs. Cued recall success effects over anterior and posterior areas were apparent in several time windows. In anterior locations, these recall success effects were similar for concurrently and sequentially encoded pairs. However, in posterior sites clustered over parietal scalp the effect was larger for the retrieval of sequentially encoded pairs. We suggest that anterior aspects of the mid-latency recall success effects may reflect working-with-memory operations or direct access recall processes, while more posterior aspects reflect recollective processes which are required for retrieval of episodes of greater temporal complexity. Copyright © 2013 Elsevier Inc. All rights reserved.

Salience driven value integration explains decision biases and preference reversal

PubMed Central

Tsetsos, Konstantinos; Chater, Nick; Usher, Marius

2012-01-01

Human choice behavior exhibits many paradoxical and challenging patterns. Traditional explanations focus on how values are represented, but little is known about how values are integrated. Here we outline a psychophysical task for value integration that can be used as a window on high-level, multiattribute decisions. Participants choose between alternative rapidly presented streams of numerical values. By controlling the temporal distribution of the values, we demonstrate that this process underlies many puzzling choice paradoxes, such as temporal, risk, and framing biases, as well as preference reversals. These phenomena can be explained by a simple mechanism based on the integration of values, weighted by their salience. The salience of a sampled value depends on its temporal order and momentary rank in the decision context, whereas the direction of the weighting is determined by the task framing. We show that many known choice anomalies may arise from the microstructure of the value integration process. PMID:22635271

Functional correlates of musical and visual ability in frontotemporal dementia.

PubMed

Miller, B L; Boone, K; Cummings, J L; Read, S L; Mishkin, F

2000-05-01

The emergence of new skills in the setting of dementia suggests that loss of function in one brain area can release new functions elsewhere. To characterise 12 patients with frontotemporal dementia (FTD) who acquired, or sustained, new musical or visual abilities despite progression of their dementia. Twelve patients with FTD who acquired or maintained musical or artistic ability were compared with 46 patients with FTD in whom new or sustained ability was absent. The group with musical or visual ability performed better on visual, but worse on verbal tasks than did the other patients with FTD. Nine had asymmetrical left anterior dysfunction. Nine showed the temporal lobe variant of FTD. Loss of function in the left anterior temporal lobe may lead to facilitation of artistic or musical skills. Patients with the left-sided temporal lobe variant of FTD offer an unexpected window into the neurological mediation of visual and musical talents.

The NIST Real-Time Control System (RCS): A Reference Model Architecture for Computational Intelligence

NASA Technical Reports Server (NTRS)

Albus, James S.

1996-01-01

The Real-time Control System (RCS) developed at NIST and elsewhere over the past two decades defines a reference model architecture for design and analysis of complex intelligent control systems. The RCS architecture consists of a hierarchically layered set of functional processing modules connected by a network of communication pathways. The primary distinguishing feature of the layers is the bandwidth of the control loops. The characteristic bandwidth of each level is determined by the spatial and temporal integration window of filters, the temporal frequency of signals and events, the spatial frequency of patterns, and the planning horizon and granularity of the planners that operate at each level. At each level, tasks are decomposed into sequential subtasks, to be performed by cooperating sets of subordinate agents. At each level, signals from sensors are filtered and correlated with spatial and temporal features that are relevant to the control function being implemented at that level.

Adjoint-Based Climate Model Tuning: Application to the Planet Simulator

NASA Astrophysics Data System (ADS)

Lyu, Guokun; Köhl, Armin; Matei, Ion; Stammer, Detlef

2018-01-01

The adjoint method is used to calibrate the medium complexity climate model "Planet Simulator" through parameter estimation. Identical twin experiments demonstrate that this method can retrieve default values of the control parameters when using a long assimilation window of the order of 2 months. Chaos synchronization through nudging, required to overcome limits in the temporal assimilation window in the adjoint method, is employed successfully to reach this assimilation window length. When assimilating ERA-Interim reanalysis data, the observations of air temperature and the radiative fluxes are the most important data for adjusting the control parameters. The global mean net longwave fluxes at the surface and at the top of the atmosphere are significantly improved by tuning two model parameters controlling the absorption of clouds and water vapor. The global mean net shortwave radiation at the surface is improved by optimizing three model parameters controlling cloud optical properties. The optimized parameters improve the free model (without nudging terms) simulation in a way similar to that in the assimilation experiments. Results suggest a promising way for tuning uncertain parameters in nonlinear coupled climate models.

M13 phage-functionalized single-walled carbon nanotubes as nanoprobes for second near-infrared window fluorescence imaging of targeted tumors.

PubMed

Yi, Hyunjung; Ghosh, Debadyuti; Ham, Moon-Ho; Qi, Jifa; Barone, Paul W; Strano, Michael S; Belcher, Angela M

2012-03-14

Second near-infrared (NIR) window light (950-1400 nm) is attractive for in vivo fluorescence imaging due to its deep penetration depth in tissues and low tissue autofluorescence. Here we show genetically engineered multifunctional M13 phage can assemble fluorescent single-walled carbon nanotubes (SWNTs) and ligands for targeted fluorescence imaging of tumors. M13-SWNT probe is detectable in deep tissues even at a low dosage of 2 μg/mL and up to 2.5 cm in tissue-like phantoms. Moreover, targeted probes show specific and up to 4-fold improved uptake in prostate specific membrane antigen positive prostate tumors compared to control nontargeted probes. This M13 phage-based second NIR window fluorescence imaging probe has great potential for specific detection and therapy monitoring of hard-to-detect areas. © 2012 American Chemical Society

M13 phage-functionalized single-walled carbon nanotubes as nanoprobes for second near-infrared window fluorescence imaging of targeted tumors

PubMed Central

HAM, MOON-HO; QI, JIFA; BARONE, PAUL W.; STRANO, MICHAEL S.; BELCHER, ANGELA M.

2014-01-01

Second near-infrared (NIR) window light (950-1,400 nm) is attractive for in vivo fluorescence imaging due to its deep penetration depth in tissues and low tissue autofluorescence. Here we show genetically engineered multifunctional M13 phage can assemble fluorescent single-walled carbon nanotubes (SWNTs) and ligands for targeted fluorescence imaging of tumors. M13-SWNT probe is detectable in deep tissues even at a low dosage of 2 μg/mL and up to 2.5 cm in tissue-like phantoms. Moreover, targeted probes show specific and up to four-fold improved uptake in prostate specific membrane antigen positive prostate tumors compared to control non-targeted probes. This M13 phage-based second NIR window fluorescence imaging probe has great potential for specific detection and therapy monitoring of hard-to-detect areas. PMID:22268625

Launch window analysis of satellites in high eccentricity or large circular orbits

NASA Technical Reports Server (NTRS)

Renard, M. L.; Bhate, S. K.; Sridharan, R.

1973-01-01

Numerical methods and computer programs for studying the stability and evolution of orbits of large eccentricity are presented. Methods for determining launch windows and target dates are developed. Mathematical models are prepared to analyze the characteristics of specific missions.

Intelligent windows using new thermotropic layers with long-term stability

NASA Astrophysics Data System (ADS)

Watanabe, Haruo

1995-08-01

This paper concerns the autonomous responsive type light adjustment window (intelligent windows) among smart windows which adjust the light upon receiving environmental energy. More specifically, this is a thermotropic window panel that laminates and seals a new type of highly viscous polymer aqueous solution gel. A conventional thermotropic window panel has never been put to practical use since the reversible change between the colorless, transparent state (water-clear) and translucent scattered state (paper-white) with uniformity was not possible. The change involved phase separation and generated non-uniformity. The author, after fundamental studies of hydrophobic bonding, successfully solved the problem by developing a polymer aqueous solution gel with amphiphatic molecule as the third component in addition to water and water-soluble polymer with hydrophobic radical, based on the molecular spacer concept. In addition, the author established peripheral technologies and succeeded in experimentally fabricating a panel type 'Affinity's Intelligent Window (AIW)' that has attained the level of practical use.

A spatio-temporal index for aerial full waveform laser scanning data

NASA Astrophysics Data System (ADS)

Laefer, Debra F.; Vo, Anh-Vu; Bertolotto, Michela

2018-04-01

Aerial laser scanning is increasingly available in the full waveform version of the raw signal, which can provide greater insight into and control over the data and, thus, richer information about the scanned scenes. However, when compared to conventional discrete point storage, preserving raw waveforms leads to vastly larger and more complex data volumes. To begin addressing these challenges, this paper introduces a novel bi-level approach for storing and indexing full waveform (FWF) laser scanning data in a relational database environment, while considering both the spatial and the temporal dimensions of that data. In the storage scheme's upper level, the full waveform datasets are partitioned into spatial and temporal coherent groups that are indexed by a two-dimensional R∗-tree. To further accelerate intra-block data retrieval, at the lower level a three-dimensional local octree is created for each pulse block. The local octrees are implemented in-memory and can be efficiently written to a database for reuse. The indexing solution enables scalable and efficient three-dimensional (3D) spatial and spatio-temporal queries on the actual pulse data - functionalities not available in other systems. The proposed FWF laser scanning data solution is capable of managing multiple FWF datasets derived from large flight missions. The flight structure is embedded into the data storage model and can be used for querying predicates. Such functionality is important to FWF data exploration since aircraft locations and orientations are frequently required for FWF data analyses. Empirical tests on real datasets of up to 1 billion pulses from Dublin, Ireland prove the almost perfect scalability of the system. The use of the local 3D octree in the indexing structure accelerated pulse clipping by 1.2-3.5 times for non-axis-aligned (NAA) polyhedron shaped clipping windows, while axis-aligned (AA) polyhedron clipping was better served using only the top indexing layer. The distinct behaviours of the hybrid indexing for AA and NAA clipping windows are attributable to the different proportion of the local-index-related overheads with respect to the total querying costs. When temporal constraints were added, generally the number of costly spatial checks were reduced, thereby shortening the querying times.

Time-varying spatial data integration and visualization: 4 Dimensions Environmental Observations Platform (4-DEOS)

NASA Astrophysics Data System (ADS)

Paciello, Rossana; Coviello, Irina; Filizzola, Carolina; Genzano, Nicola; Lisi, Mariano; Mazzeo, Giuseppe; Pergola, Nicola; Sileo, Giancanio; Tramutoli, Valerio

2014-05-01

In environmental studies the integration of heterogeneous and time-varying data, is a very common requirement for investigating and possibly visualize correlations among physical parameters underlying the dynamics of complex phenomena. Datasets used in such kind of applications has often different spatial and temporal resolutions. In some case superimposition of asynchronous layers is required. Traditionally the platforms used to perform spatio-temporal visual data analyses allow to overlay spatial data, managing the time using 'snapshot' data model, each stack of layers being labeled with different time. But this kind of architecture does not incorporate the temporal indexing neither the third spatial dimension which is usually given as an independent additional layer. Conversely, the full representation of a generic environmental parameter P(x,y,z,t) in the 4D space-time domain could allow to handle asynchronous datasets as well as less traditional data-products (e.g. vertical sections, punctual time-series, etc.) . In this paper we present the 4 Dimensions Environmental Observation Platform (4-DEOS), a system based on a web services architecture Client-Broker-Server. This platform is a new open source solution for both a timely access and an easy integration and visualization of heterogeneous (maps, vertical profiles or sections, punctual time series, etc.) asynchronous, geospatial products. The innovative aspect of the 4-DEOS system is that users can analyze data/products individually moving through time, having also the possibility to stop the display of some data/products and focus on other parameters for better studying their temporal evolution. This platform gives the opportunity to choose between two distinct display modes for time interval or for single instant. Users can choose to visualize data/products in two ways: i) showing each parameter in a dedicated window or ii) visualize all parameters overlapped in a single window. A sliding time bar, allows to follow the temporal evolution of the selected data/product. With this software, users have the possibility to identify events partially correlated each other not only in the spatial dimension but also in the time domain even at different time lags.

Electrical Neuroimaging of Music Processing Reveals Mid-Latency Changes with Level of Musical Expertise

PubMed Central

James, Clara E.; Oechslin, Mathias S.; Michel, Christoph M.; De Pretto, Michael

2017-01-01

This original research focused on the effect of musical training intensity on cerebral and behavioral processing of complex music using high-density event-related potential (ERP) approaches. Recently we have been able to show progressive changes with training in gray and white matter, and higher order brain functioning using (f)MRI [(functional) Magnetic Resonance Imaging], as well as changes in musical and general cognitive functioning. The current study investigated the same population of non-musicians, amateur pianists and expert pianists using spatio-temporal ERP analysis, by means of microstate analysis, and ERP source imaging. The stimuli consisted of complex musical compositions containing three levels of transgression of musical syntax at closure that participants appraised. ERP waveforms, microstates and underlying brain sources revealed gradual differences according to musical expertise in a 300–500 ms window after the onset of the terminal chords of the pieces. Within this time-window, processing seemed to concern context-based memory updating, indicated by a P3b-like component or microstate for which underlying sources were localized in the right middle temporal gyrus, anterior cingulate and right parahippocampal areas. Given that the 3 expertise groups were carefully matched for demographic factors, these results provide evidence of the progressive impact of training on brain and behavior. PMID:29163017

The periosteal requirement and temporal dynamics of BMP2‐induced middle phalanx regeneration in the adult mouse

PubMed Central

Dawson, Lindsay A.; Yu, Ling; Yan, Mingquan; Marrero, Luis; Schanes, Paula P.; Dolan, Connor; Pela, Maegan; Petersen, Britta; Han, Manjong

2017-01-01

Abstract Regeneration of mammalian limbs is restricted to amputation of the distal digit tip, the terminal phalanx (P3). The adjacent skeletal element, the middle phalanx (P2), has emerged as a model system to investigate regenerative failure and as a site to test approaches aimed at enhancing regeneration. We report that exogenous application of bone morphogenetic protein 2 (BMP2) stimulates the formation of a transient cartilaginous callus distal to the amputation plane that mediates the regeneration of the amputated P2 bone. BMP2 initiates a significant regeneration response during the periosteal‐derived cartilaginous healing phase of P2 bone repair, yet fails to induce regeneration in the absence of periosteal tissue, or after boney callus formation. We provide evidence that a temporal component exists in the induced regeneration of P2 that we define as the “regeneration window.” In this window, cells are transiently responsive to BMP2 after the amputation injury. Simple re‐injury of the healed P2 stump acts to reinitiate endogenous bone repair, complete with periosteal chondrogenesis, thus reopening the “regeneration window” and thereby recreating a regeneration‐permissive environment that is responsive to exogenous BMP2 treatment. PMID:28975034

Episodic Future Thinking: Expansion of the Temporal Window in Individuals with Alcohol Dependence.

PubMed

Snider, Sarah E; LaConte, Stephen M; Bickel, Warren K

2016-07-01

Episodic future thinking (EFT) requires an individual to vividly pre-experience a realistic future event. Inspired by previous reports of reducing delay discounting following EFT in other populations, we examined the effects of engaging alcohol-dependent individuals in EFT or episodic recent thinking (ERT; control) to examine its effects on delay discounting and alcohol purchasing. Participants (n = 50) with alcohol dependence were allocated into EFT or ERT groups and asked to generate positive future or recent past events for each of 5 time points. Participants then completed a delay-discounting task, during which event cues were displayed, and a hypothetical alcohol purchase task. EFT significantly increased valuation of future monetary rewards, while decreasing initial consumption (Q0 ) of alcoholic drinks indicative of lower demand intensity. Two additional findings suggest potential moderators of this effect. EFT more readily influenced individuals with lower Alcohol Use Disorders Identification Test scores, and self-reported cue valence differed between groups. Together, these results suggest a widening of alcohol-dependent individuals' temporal window following engagement of EFT. While our data suggest that EFT may be moderated by certain susceptibility criteria, exercises such as EFT could be easily adaptable as a potential therapeutic tool for use in rehabilitation programs. Copyright © 2016 by the Research Society on Alcoholism.

Electrical Neuroimaging of Music Processing Reveals Mid-Latency Changes with Level of Musical Expertise.

PubMed

James, Clara E; Oechslin, Mathias S; Michel, Christoph M; De Pretto, Michael

2017-01-01

This original research focused on the effect of musical training intensity on cerebral and behavioral processing of complex music using high-density event-related potential (ERP) approaches. Recently we have been able to show progressive changes with training in gray and white matter, and higher order brain functioning using (f)MRI [(functional) Magnetic Resonance Imaging], as well as changes in musical and general cognitive functioning. The current study investigated the same population of non-musicians, amateur pianists and expert pianists using spatio-temporal ERP analysis, by means of microstate analysis, and ERP source imaging. The stimuli consisted of complex musical compositions containing three levels of transgression of musical syntax at closure that participants appraised. ERP waveforms, microstates and underlying brain sources revealed gradual differences according to musical expertise in a 300-500 ms window after the onset of the terminal chords of the pieces. Within this time-window, processing seemed to concern context-based memory updating, indicated by a P3b-like component or microstate for which underlying sources were localized in the right middle temporal gyrus, anterior cingulate and right parahippocampal areas. Given that the 3 expertise groups were carefully matched for demographic factors, these results provide evidence of the progressive impact of training on brain and behavior.

Improving the therapeutic window of retinal photocoagulation by spatial and temporal modulation of the laser beam

NASA Astrophysics Data System (ADS)

Sramek, Christopher; Leung, Loh-Shan; Leng, Theodore; Brown, Jefferson; Paulus, Yannis M.; Schuele, Georg; Palanker, Daniel

2011-02-01

Decreasing the pulse duration helps confine damage, shorten treatment time, and minimize pain during retinal photocoagulation. However, the safe therapeutic window (TW), the ratio of threshold powers for thermomechanical rupture of Bruch's membrane and mild coagulation, also decreases with shorter exposures. Two potential approaches toward increasing TW are investigated: (a) decreasing the central irradiance of the laser beam and (b) temporally modulating the pulse. An annular beam with adjustable central irradiance was created by coupling a 532-nm laser into a 200-μm core multimode optical fiber at a 4-7 deg angle to normal incidence. Pulse shapes were optimized using a computational model, and a waveform generator was used to drive a PASCAL photocoagulator (532 nm), producing modulated laser pulses. Acute thresholds for mild coagulation and rupture were measured in Dutch-Belted rabbit in vivo with an annular beam (154-163 μm retinal diameter) and modulated pulse (132 μm, uniform irradiance ``flat-top'' beam) with 2-50 ms pulse durations. Thresholds with conventional constant-power pulse and a flat-top beam were also determined. Both annular beam and modulated pulse provided a 28% increase in TW at 10-ms duration, affording the same TW as 20-ms pulses with conventional parameters.

Earthquake Occurrence in Bangladesh and Surrounding Region

NASA Astrophysics Data System (ADS)

Al-Hussaini, T. M.; Al-Noman, M.

2011-12-01

The collision of the northward moving Indian plate with the Eurasian plate is the cause of frequent earthquakes in the region comprising Bangladesh and neighbouring India, Nepal and Myanmar. Historical records indicate that Bangladesh has been affected by five major earthquakes of magnitude greater than 7.0 (Richter scale) during 1869 to 1930. This paper presents some statistical observations of earthquake occurrence in fulfilment of a basic groundwork for seismic hazard assessment of this region. An up to date catalogue covering earthquake information in the region bounded within 17°-30°N and 84°-97°E for the period of historical period to 2010 is derived from various reputed international sources including ISC, IRIS, Indian sources and available publications. Careful scrutiny is done to remove duplicate or uncertain earthquake events. Earthquake magnitudes in the range of 1.8 to 8.1 have been obtained and relationships between different magnitude scales have been studied. Aftershocks are removed from the catalogue using magnitude dependent space window and time window. The main shock data are then analyzed to obtain completeness period for different magnitudes evaluating their temporal homogeneity. Spatial and temporal distribution of earthquakes, magnitude-depth histograms and other statistical analysis are performed to understand the distribution of seismic activity in this region.

Dynamic Granger-Geweke causality modeling with application to interictal spike propagation

PubMed Central

Lin, Fa-Hsuan; Hara, Keiko; Solo, Victor; Vangel, Mark; Belliveau, John W.; Stufflebeam, Steven M.; Hamalainen, Matti S.

2010-01-01

A persistent problem in developing plausible neurophysiological models of perception, cognition, and action is the difficulty of characterizing the interactions between different neural systems. Previous studies have approached this problem by estimating causal influences across brain areas activated during cognitive processing using Structural Equation Modeling and, more recently, with Granger-Geweke causality. While SEM is complicated by the need for a priori directional connectivity information, the temporal resolution of dynamic Granger-Geweke estimates is limited because the underlying autoregressive (AR) models assume stationarity over the period of analysis. We have developed a novel optimal method for obtaining data-driven directional causality estimates with high temporal resolution in both time and frequency domains. This is achieved by simultaneously optimizing the length of the analysis window and the chosen AR model order using the SURE criterion. Dynamic Granger-Geweke causality in time and frequency domains is subsequently calculated within a moving analysis window. We tested our algorithm by calculating the Granger-Geweke causality of epileptic spike propagation from the right frontal lobe to the left frontal lobe. The results quantitatively suggested the epileptic activity at the left frontal lobe was propagated from the right frontal lobe, in agreement with the clinical diagnosis. Our novel computational tool can be used to help elucidate complex directional interactions in the human brain. PMID:19378280

Identification of repeating earthquakes and spatio-temporal variations of fault zone properties around the Parkfield section of the San Andreas fault and the central Calaveras fault

NASA Astrophysics Data System (ADS)

Zhao, P.; Peng, Z.

2008-12-01

We systemically identify repeating earthquakes and investigate spatio-temporal variations of fault zone properties associated with the 2004 Mw6.0 Parkfield earthquake along the Parkfield section of the San Andreas fault, and the 1984 Mw6.2 Morgan Hill earthquake along the central Calaveras fault. The procedure for identifying repeating earthquakes is based on overlapping of the source regions and the waveform similarity, and is briefly described as follows. First, we estimate the source radius of each event based on a circular crack model and a normal stress drop of 3 MPa. Next, we compute inter-hypocentral distance for events listed in the relocated catalog of Thurber et al. (2006) around Parkfield, and Schaff et al. (2002) along the Calaveras fault. Then, we group all events into 'initial' clusters by requiring the separation distance between each event pair to be less than the source radius of larger event, and their magnitude difference to be less than 1. Next, we calculate the correlation coefficients between every event pair within each 'initial' cluster using a 3-s time window around the direct P waves for all available stations. The median value of the correlation coefficients is used as a measure of similarity between each event pair. We drop an event if the median similarity to the rest events in that cluster is less than 0.9. After identifying repeating clusters in both regions, our next step is to apply a sliding window waveform cross-correlation technique (Niu et al., 2003; Peng and Ben-Zion, 2006) to calculate the delay time and decorrelation index for each repeating cluster. By measuring temporal changes in waveforms of repeating clusters at different locations and depth, we hope to obtain a better constraint on spatio-temporal variations of fault zone properties and near-surface layers associated with the occurrence of major earthquakes.

Spatial attention does improve temporal discrimination.

PubMed

Chica, Ana B; Christie, John

2009-02-01

It has recently been stated that exogenous attention impairs temporal-resolution tasks (Hein, Rolke, & Ulrich, 2006; Rolke, Dinkelbach, Hein, & Ulrich, 2008; Yeshurun, 2004; Yeshurun & Levy, 2003). In comparisons of performance on spatially cued trials versus neutral cued trials, the results have suggested that spatial attention decreases temporal resolution. However, when performance on cued and uncued trials has been compared in order to equate for cue salience, typically speed-accuracy trade-offs (SATs) have been observed, making the interpretation of the results difficult. In the present experiments, we aimed at studying the effect of spatial attention in temporal resolution while using a procedure to control for SATs. We controlled reaction times (RTs) by constraining the time to respond, so that response decisions would be made within comparable time windows. The results revealed that when RT was controlled, performance was impaired for cued trials as compared with neutral trials, replicating previous findings. However, when cued and uncued trials were compared, performance was actually improved for cued trials as compared with uncued trials. These results suggest that SAT effects may have played an important role in the previous studies, because when they were controlled and measured, the results reversed, revealing that exogenous attention does improve performance on temporal-resolution tasks.

Developmental windows of breast cancer risk provide opportunities for targeted chemoprevention

PubMed Central

Martinson, Holly A.; Lyons, Traci R.; Giles, Erin D.; Borges, Virginia F.; Schedin, Pepper

2014-01-01

The magnitude of the breast cancer problem implores researchers to aggressively investigate prevention strategies. However, several barriers currently reduce the feasibility of breast cancer prevention. These barriers include the inability to accurately predict future breast cancer diagnosis at the individual level, the need for improved understanding of when to implement interventions, uncertainty with respect to optimal duration of treatment, and negative side effects associated with currently approved chemoprevention therapies. None-the-less, the unique biology of the mammary gland, with its postnatal development and conditional terminal differentiation, may permit the resolution of many of these barriers. Specifically, lifecycle-specific windows of breast cancer risk have been identified that may be amenable to risk-reducing strategies. Here, we argue for prevention research focused on two of these lifecycle windows of risk: postpartum mammary gland involution and peri-menopause. We provide evidence that these windows are highly amenable to targeted, limited duration treatments. Such approaches could result in the prevention of postpartum and postmenopausal breast cancers, correspondingly. PMID:23664839

Temporal Dependency and the Structure of Early Looking.

PubMed

Messinger, Daniel S; Mattson, Whitney I; Todd, James Torrence; Gangi, Devon N; Myers, Nicholas D; Bahrick, Lorraine E

2017-01-01

Although looking time is used to assess infant perceptual and cognitive processing, little is known about the temporal structure of infant looking. To shed light on this temporal structure, 127 three-month-olds were assessed in an infant-controlled habituation procedure and presented with a pre-recorded display of a woman addressing the infant using infant-directed speech. Previous individual look durations positively predicted subsequent look durations over a six look window, suggesting a temporal dependency between successive infant looks. The previous look duration continued to predict the subsequent look duration after accounting for habituation-linked declines in look duration, and when looks were separated by an inter-trial interval in which no stimulus was displayed. Individual differences in temporal dependency, the strength of associations between consecutive look durations, are distinct from individual differences in mean infant look duration. Nevertheless, infants with stronger temporal dependency had briefer mean look durations, a potential index of stimulus processing. Temporal dependency was evident not only between individual infant looks but between the durations of successive habituation trials (total looking within a trial). Finally, temporal dependency was evident in associations between the last look at the habituation stimulus and the first look at a novel test stimulus. Thus temporal dependency was evident across multiple timescales (individual looks and trials comprised of multiple individual looks) and persisted across conditions including brief periods of no stimulus presentation and changes from a familiar to novel stimulus. Associations between consecutive look durations over multiple timescales and stimuli suggest a temporal structure of infant attention that has been largely ignored in previous work on infant looking.

Temporal Dependency and the Structure of Early Looking

PubMed Central

Messinger, Daniel S.; Mattson, Whitney I.; Todd, James Torrence; Gangi, Devon N.; Myers, Nicholas D.; Bahrick, Lorraine E.

2017-01-01

Although looking time is used to assess infant perceptual and cognitive processing, little is known about the temporal structure of infant looking. To shed light on this temporal structure, 127 three-month-olds were assessed in an infant-controlled habituation procedure and presented with a pre-recorded display of a woman addressing the infant using infant-directed speech. Previous individual look durations positively predicted subsequent look durations over a six look window, suggesting a temporal dependency between successive infant looks. The previous look duration continued to predict the subsequent look duration after accounting for habituation-linked declines in look duration, and when looks were separated by an inter-trial interval in which no stimulus was displayed. Individual differences in temporal dependency, the strength of associations between consecutive look durations, are distinct from individual differences in mean infant look duration. Nevertheless, infants with stronger temporal dependency had briefer mean look durations, a potential index of stimulus processing. Temporal dependency was evident not only between individual infant looks but between the durations of successive habituation trials (total looking within a trial). Finally, temporal dependency was evident in associations between the last look at the habituation stimulus and the first look at a novel test stimulus. Thus temporal dependency was evident across multiple timescales (individual looks and trials comprised of multiple individual looks) and persisted across conditions including brief periods of no stimulus presentation and changes from a familiar to novel stimulus. Associations between consecutive look durations over multiple timescales and stimuli suggest a temporal structure of infant attention that has been largely ignored in previous work on infant looking. PMID:28076362

Thin and open vessel windows for intra-vital fluorescence imaging of murine cochlear blood flow.

PubMed

Shi, Xiaorui; Zhang, Fei; Urdang, Zachary; Dai, Min; Neng, Lingling; Zhang, Jinhui; Chen, Songlin; Ramamoorthy, Sripriya; Nuttall, Alfred L

2014-07-01

Normal microvessel structure and function in the cochlea is essential for maintaining the ionic and metabolic homeostasis required for hearing function. Abnormal cochlear microcirculation has long been considered an etiologic factor in hearing disorders. A better understanding of cochlear blood flow (CoBF) will enable more effective amelioration of hearing disorders that result from aberrant blood flow. However, establishing the direct relationship between CoBF and other cellular events in the lateral wall and response to physio-pathological stress remains a challenge due to the lack of feasible interrogation methods and difficulty in accessing the inner ear. Here we report on new methods for studying the CoBF in a mouse model using a thin or open vessel-window in combination with fluorescence intra-vital microscopy (IVM). An open vessel-window enables investigation of vascular cell biology and blood flow permeability, including pericyte (PC) contractility, bone marrow cell migration, and endothelial barrier leakage, in wild type and fluorescent protein-labeled transgenic mouse models with high spatial and temporal resolution. Alternatively, the thin vessel-window method minimizes disruption of the homeostatic balance in the lateral wall and enables study CoBF under relatively intact physiological conditions. A thin vessel-window method can also be used for time-based studies of physiological and pathological processes. Although the small size of the mouse cochlea makes surgery difficult, the methods are sufficiently developed for studying the structural and functional changes in CoBF under normal and pathological conditions. Copyright © 2014 Elsevier B.V. All rights reserved.

Risk of lung cancer in relation to contiguous windows of endotoxin exposure among female textile workers in Shanghai

PubMed Central

Costello, Sadie; Applebaum, Katie M.; Ray, Roberta M.; Astrakianakis, George; Gao, Dao Li; Thomas, David B.; Checkoway, Harvey; Eisen, Ellen A.

2012-01-01

Objective Exposure to endotoxin has been consistently associated with a reduced risk of lung cancer. However, there is a paucity of information regarding temporal aspects of this relationship. The objective of this study was to investigate the associations between contiguous windows of endotoxin exposure and risk of lung cancer. Methods Data were reanalyzed from a case-cohort study (602 cases, 3,038 subcohort) of female textile workers in Shanghai, China. Cumulative endotoxin exposure was partitioned into two windows: ≥20 and <20 years before risk. Exposure–response relations were examined using categorical and non-linear (semi-parametric) models, accounting for confounding by previous exposure windows. Results There was an inverse trend of decreasing risk of lung cancer associated with increasing levels of endotoxin exposure ≥20 years before risk (p trend = 0.02). Women in the highest two categories of cumulative exposures had hazard ratios of 0.78 (95% CI 0.60–1.03) and 0.77 (95% CI 0.58–1.02) for lung cancer, respectively, in comparison with unexposed textile workers. There was, however, a weaker association and not statistically significant between lung cancer and endotoxin exposure accumulated in the more recent window (<20 years before risk). Conclusion Results provide further evidence that endotoxin exposure that occurred 20 years or more before risk confers the strongest protection against lung cancer, indicating a possible early anti-carcinogenic effect. Further studies are needed to better understand the underlying biological mechanisms for this effect. PMID:21732048

Investigation of Fuel Oil/Lube Oil Spray Fires On Board Vessels. Volume 3.

DTIC Science & Technology

1998-11-01

U.S. Coast Guard Research and Development Center 1082 Shennecossett Road, Groton, CT 06340-6096 Report No. CG-D-01-99, III Investigation of Fuel ...refinery). Developed the technical and mathematical specifications for BRAVO™2.0, a state-of-the-art Windows program for performing event tree and fault...tree analyses. Also managed the development of and prepared the technical specifications for QRA ROOTS™, a Windows program for storing, searching K-4

The association between sterilizing activity and drug distribution into tuberculosis lesions

PubMed Central

Prideaux, Brendan; Via, Laura E.; Zimmerman, Matthew D.; Eum, Seokyong; Sarathy, Jansy; O’Brien, Paul; Chen, Chao; Kaya, Firat; Weiner, Danielle M.; Chen, Pei-Yu; Song, Taeksun; Lee, Myungsun; Shim, TaeSun; Cho, Jeong Su; Kim, Wooshik; Cho, Sang Nae; Olivier, Kenneth N.; Barry, Clifton E.; Dartois, Véronique

2015-01-01

Finding new treatment-shortening antibiotics to improve cure rates and curb the alarming emergence of drug resistance is the major objective of tuberculosis (TB) drug development. Using a MALDI mass spectrometry imaging suite in a biosafety containment facility, we show that the key sterilizing drugs rifampicin and pyrazinamide efficiently penetrate the sites of TB infection in lung lesions. Rifampicin even accumulates in necrotic caseum, a critical lesion site where persisting tubercle bacilli reside1. In contrast, moxifloxacin which is active in vitro against persisters, a sub-population of Mycobacterium tuberculosis that persists in specific niches under drug pressure, and achieved treatment shortening in mice2, does not diffuse well in caseum, concordant with its failure to shorten therapy in recent clinical trials. We also suggest that such differential spatial distribution and kinetics of accumulation in lesions may create temporal and spatial windows of monotherapy in specific niches, allowing the gradual development of multidrug resistant TB. We propose an alternative working model to prioritize new antibiotic regimens based on quantitative and spatial distribution of TB drugs in the major lesion types found in human lungs. The finding that lesion penetration contributes to treatment outcome has wide implications for TB. PMID:26343800

Determining the frequency of open windows in motor vehicles: a pilot study using a video camera in Houston, Texas during high temperature conditions.

PubMed

Long, Tom; Johnson, Ted; Ollison, Will

2002-05-01

Researchers have developed a variety of computer-based models to estimate population exposure to air pollution. These models typically estimate exposures by simulating the movement of specific population groups through defined microenvironments. Exposures in the motor vehicle microenvironment are significantly affected by air exchange rate, which in turn is affected by vehicle speed, window position, vent status, and air conditioning use. A pilot study was conducted in Houston, Texas, during September 2000 for a specific set of weather, vehicle speed, and road type conditions to determine whether useful information on the position of windows, sunroofs, and convertible tops could be obtained through the use of video cameras. Monitoring was conducted at three sites (two arterial roads and one interstate highway) on the perimeter of Harris County located in or near areas not subject to mandated Inspection and Maintenance programs. Each site permitted an elevated view of vehicles as they proceeded through a turn, thereby exposing all windows to the stationary video camera. Five videotaping sessions were conducted over a two-day period in which the Heat Index (HI)-a function of temperature and humidity-varied from 80 to 101 degrees F and vehicle speed varied from 30 to 74 mph. The resulting videotapes were processed to create a master database listing vehicle-specific data for site location, date, time, vehicle type (e.g., minivan), color, window configuration (e.g., four windows and sunroof), number of windows in each of three position categories (fully open, partially open, and closed), HI, and speed. Of the 758 vehicles included in the database, 140 (18.5 percent) were labeled as "open," indicating a window, sunroof, or convertible top was fully or partially open. The results of a series of stepwise linear regression analyses indicated that the probability of a vehicle in the master database being "open" was weakly affected by time of day, vehicle type, vehicle color, vehicle speed, and HI. In particular, open windows occurred more frequently when vehicle speed was less than 50 mph during periods when HI exceeded 99.9 degrees F and the vehicle was a minivan or passenger van. Overall, the pilot study demonstrated that data on factors affecting vehicle window position could be acquired through a relatively simple experimental protocol using a single video camera. Limitations of the study requiring further research include the inability to determine the status of the vehicle air conditioning system; lack of a wide range of weather, vehicle speed, and road type conditions; and the need to exclude some vehicles from statistical analyses due to ambiguous window positions.

On the limits of statistical learning: Intertrial contextual cueing is confined to temporally close contingencies.

PubMed

Thomas, Cyril; Didierjean, André; Maquestiaux, François; Goujon, Annabelle

2018-04-12

Since the seminal study by Chun and Jiang (Cognitive Psychology, 36, 28-71, 1998), a large body of research based on the contextual-cueing paradigm has shown that the cognitive system is capable of extracting statistical contingencies from visual environments. Most of these studies have focused on how individuals learn regularities found within an intratrial temporal window: A context predicts the target position within a given trial. However, Ono, Jiang, and Kawahara (Journal of Experimental Psychology, 31, 703-712, 2005) provided evidence of an intertrial implicit-learning effect when a distractor configuration in preceding trials N - 1 predicted the target location in trials N. The aim of the present study was to gain further insight into this effect by examining whether it occurs when predictive relationships are impeded by interfering task-relevant noise (Experiments 2 and 3) or by a long delay (Experiments 1, 4, and 5). Our results replicated the intertrial contextual-cueing effect, which occurred in the condition of temporally close contingencies. However, there was no evidence of integration across long-range spatiotemporal contingencies, suggesting a temporal limitation of statistical learning.

Audiovisual Simultaneity Judgment and Rapid Recalibration throughout the Lifespan.

PubMed

Noel, Jean-Paul; De Niear, Matthew; Van der Burg, Erik; Wallace, Mark T

2016-01-01

Multisensory interactions are well established to convey an array of perceptual and behavioral benefits. One of the key features of multisensory interactions is the temporal structure of the stimuli combined. In an effort to better characterize how temporal factors influence multisensory interactions across the lifespan, we examined audiovisual simultaneity judgment and the degree of rapid recalibration to paired audiovisual stimuli (Flash-Beep and Speech) in a sample of 220 participants ranging from 7 to 86 years of age. Results demonstrate a surprisingly protracted developmental time-course for both audiovisual simultaneity judgment and rapid recalibration, with neither reaching maturity until well into adolescence. Interestingly, correlational analyses revealed that audiovisual simultaneity judgments (i.e., the size of the audiovisual temporal window of simultaneity) and rapid recalibration significantly co-varied as a function of age. Together, our results represent the most complete description of age-related changes in audiovisual simultaneity judgments to date, as well as being the first to describe changes in the degree of rapid recalibration as a function of age. We propose that the developmental time-course of rapid recalibration scaffolds the maturation of more durable audiovisual temporal representations.

Wavelength selection method with standard deviation: application to pulse oximetry.

PubMed

Vazquez-Jaccaud, Camille; Paez, Gonzalo; Strojnik, Marija

2011-07-01

Near-infrared spectroscopy provides useful biological information after the radiation has penetrated through the tissue, within the therapeutic window. One of the significant shortcomings of the current applications of spectroscopic techniques to a live subject is that the subject may be uncooperative and the sample undergoes significant temporal variations, due to his health status that, from radiometric point of view, introduce measurement noise. We describe a novel wavelength selection method for monitoring, based on a standard deviation map, that allows low-noise sensitivity. It may be used with spectral transillumination, transmission, or reflection signals, including those corrupted by noise and unavoidable temporal effects. We apply it to the selection of two wavelengths for the case of pulse oximetry. Using spectroscopic data, we generate a map of standard deviation that we propose as a figure-of-merit in the presence of the noise introduced by the living subject. Even in the presence of diverse sources of noise, we identify four wavelength domains with standard deviation, minimally sensitive to temporal noise, and two wavelengths domains with low sensitivity to temporal noise.

Pulling the Internet Together with Mosaic.

ERIC Educational Resources Information Center

Sheehan, Mark

1995-01-01

Presents the history of the Internet with specific emphasis on Mosaic; discusses hypertext and hypermedia information; and describes software and hardware requirements. Sidebars include information on the National Center for Super Computing Applications (NCSA); World Wide Web browsers for use in Windows, Macintosh, and X-Windows (UNIX); and…

A psychophysical investigation of differences between synchrony and temporal order judgments.

PubMed

Love, Scott A; Petrini, Karin; Cheng, Adam; Pollick, Frank E

2013-01-01

Synchrony judgments involve deciding whether cues to an event are in synch or out of synch, while temporal order judgments involve deciding which of the cues came first. When the cues come from different sensory modalities these judgments can be used to investigate multisensory integration in the temporal domain. However, evidence indicates that that these two tasks should not be used interchangeably as it is unlikely that they measure the same perceptual mechanism. The current experiment further explores this issue across a variety of different audiovisual stimulus types. Participants were presented with 5 audiovisual stimulus types, each at 11 parametrically manipulated levels of cue asynchrony. During separate blocks, participants had to make synchrony judgments or temporal order judgments. For some stimulus types many participants were unable to successfully make temporal order judgments, but they were able to make synchrony judgments. The mean points of subjective simultaneity for synchrony judgments were all video-leading, while those for temporal order judgments were all audio-leading. In the within participants analyses no correlation was found across the two tasks for either the point of subjective simultaneity or the temporal integration window. Stimulus type influenced how the two tasks differed; nevertheless, consistent differences were found between the two tasks regardless of stimulus type. Therefore, in line with previous work, we conclude that synchrony and temporal order judgments are supported by different perceptual mechanisms and should not be interpreted as being representative of the same perceptual process.

A Psychophysical Investigation of Differences between Synchrony and Temporal Order Judgments

PubMed Central

Love, Scott A.; Petrini, Karin; Cheng, Adam; Pollick, Frank E.

2013-01-01

Background Synchrony judgments involve deciding whether cues to an event are in synch or out of synch, while temporal order judgments involve deciding which of the cues came first. When the cues come from different sensory modalities these judgments can be used to investigate multisensory integration in the temporal domain. However, evidence indicates that that these two tasks should not be used interchangeably as it is unlikely that they measure the same perceptual mechanism. The current experiment further explores this issue across a variety of different audiovisual stimulus types. Methodology/Principal Findings Participants were presented with 5 audiovisual stimulus types, each at 11 parametrically manipulated levels of cue asynchrony. During separate blocks, participants had to make synchrony judgments or temporal order judgments. For some stimulus types many participants were unable to successfully make temporal order judgments, but they were able to make synchrony judgments. The mean points of subjective simultaneity for synchrony judgments were all video-leading, while those for temporal order judgments were all audio-leading. In the within participants analyses no correlation was found across the two tasks for either the point of subjective simultaneity or the temporal integration window. Conclusions Stimulus type influenced how the two tasks differed; nevertheless, consistent differences were found between the two tasks regardless of stimulus type. Therefore, in line with previous work, we conclude that synchrony and temporal order judgments are supported by different perceptual mechanisms and should not be interpreted as being representative of the same perceptual process. PMID:23349971

Realigning Thunder and Lightning: Temporal Adaptation to Spatiotemporally Distant Events

PubMed Central

Navarra, Jordi; Fernández-Prieto, Irune; Garcia-Morera, Joel

2013-01-01

The brain is able to realign asynchronous signals that approximately coincide in both space and time. Given that many experience-based links between visual and auditory stimuli are established in the absence of spatiotemporal proximity, we investigated whether or not temporal realignment arises in these conditions. Participants received a 3-min exposure to visual and auditory stimuli that were separated by 706 ms and appeared either from the same (Experiment 1) or from different spatial positions (Experiment 2). A simultaneity judgment task (SJ) was administered right afterwards. Temporal realignment between vision and audition was observed, in both Experiment 1 and 2, when comparing the participants’ SJs after this exposure phase with those obtained after a baseline exposure to audiovisual synchrony. However, this effect was present only when the visual stimuli preceded the auditory stimuli during the exposure to asynchrony. A similar pattern of results (temporal realignment after exposure to visual-leading asynchrony but not after exposure to auditory-leading asynchrony) was obtained using temporal order judgments (TOJs) instead of SJs (Experiment 3). Taken together, these results suggest that temporal recalibration still occurs for visual and auditory stimuli that fall clearly outside the so-called temporal window for multisensory integration and appear from different spatial positions. This temporal realignment may be modulated by long-term experience with the kind of asynchrony (vision-leading) that we most frequently encounter in the outside world (e.g., while perceiving distant events). PMID:24391928

Window of visibility - A psychophysical theory of fidelity in time-sampled visual motion displays

NASA Technical Reports Server (NTRS)

Watson, A. B.; Ahumada, A. J., Jr.; Farrell, J. E.

1986-01-01

A film of an object in motion presents on the screen a sequence of static views, while the human observer sees the object moving smoothly across the screen. Questions related to the perceptual identity of continuous and stroboscopic displays are examined. Time-sampled moving images are considered along with the contrast distribution of continuous motion, the contrast distribution of stroboscopic motion, the frequency spectrum of continuous motion, the frequency spectrum of stroboscopic motion, the approximation of the limits of human visual sensitivity to spatial and temporal frequencies by a window of visibility, the critical sampling frequency, the contrast distribution of staircase motion and the frequency spectrum of this motion, and the spatial dependence of the critical sampling frequency. Attention is given to apparent motion, models of motion, image recording, and computer-generated imagery.

Understanding face perception by means of human electrophysiology.

PubMed

Rossion, Bruno

2014-06-01

Electrophysiological recordings on the human scalp provide a wealth of information about the temporal dynamics and nature of face perception at a global level of brain organization. The time window between 100 and 200 ms witnesses the transition between low-level and high-level vision, an N170 component correlating with conscious interpretation of a visual stimulus as a face. This face representation is rapidly refined as information accumulates during this time window, allowing the individualization of faces. To improve the sensitivity and objectivity of face perception measures, it is increasingly important to go beyond transient visual stimulation by recording electrophysiological responses at periodic frequency rates. This approach has recently provided face perception thresholds and the first objective signature of integration of facial parts in the human brain. Copyright © 2014 Elsevier Ltd. All rights reserved.

Using time to investigate space: a review of tactile temporal order judgments as a window onto spatial processing in touch

PubMed Central

Heed, Tobias; Azañón, Elena

2014-01-01

To respond to a touch, it is often necessary to localize it in space, and not just on the skin. The computation of this external spatial location involves the integration of somatosensation with visual and proprioceptive information about current body posture. In the past years, the study of touch localization has received substantial attention and has become a central topic in the research field of multisensory integration. In this review, we will explore important findings from this research, zooming in on one specific experimental paradigm, the temporal order judgment (TOJ) task, which has proven particularly fruitful for the investigation of tactile spatial processing. In a typical TOJ task participants perform non-speeded judgments about the order of two tactile stimuli presented in rapid succession to different skin sites. This task could be solved without relying on external spatial coordinates. However, postural manipulations affect TOJ performance, indicating that external coordinates are in fact computed automatically. We show that this makes the TOJ task a reliable indicator of spatial remapping, and provide an overview over the versatile analysis options for TOJ. We introduce current theories of TOJ and touch localization, and then relate TOJ to behavioral and electrophysiological evidence from other paradigms, probing the benefit of TOJ for the study of spatial processing as well as related topics such as multisensory plasticity, body processing, and pain. PMID:24596561

Music, clicks, and their imaginations favor differently the event-based timing component for rhythmic movements.

PubMed

Bravi, Riccardo; Quarta, Eros; Del Tongo, Claudia; Carbonaro, Nicola; Tognetti, Alessandro; Minciacchi, Diego

2015-06-01

The involvement or noninvolvement of a clock-like neural process, an effector-independent representation of the time intervals to produce, is described as the essential difference between event-based and emergent timing. In a previous work (Bravi et al. in Exp Brain Res 232:1663-1675, 2014a. doi: 10.1007/s00221-014-3845-9 ), we studied repetitive isochronous wrist's flexion-extensions (IWFEs), performed while minimizing visual and tactile information, to clarify whether non-temporal and temporal characteristics of paced auditory stimuli affect the precision and accuracy of the rhythmic motor performance. Here, with the inclusion of new recordings, we expand the examination of the dataset described in our previous study to investigate whether simple and complex paced auditory stimuli (clicks and music) and their imaginations influence in a different way the timing mechanisms for repetitive IWFEs. Sets of IWFEs were analyzed by the windowed (lag one) autocorrelation-wγ(1), a statistical method recently introduced for the distinction between event-based and emergent timing. Our findings provide evidence that paced auditory information and its imagination favor the engagement of a clock-like neural process, and specifically that music, unlike clicks, lacks the power to elicit event-based timing, not counteracting the natural shift of wγ(1) toward positive values as frequency of movements increase.

Interference and facilitation in overt speech production investigated with event-related potentials.

PubMed

Hirschfeld, Gerrit; Jansma, Bernadette; Bölte, Jens; Zwitserlood, Pienie

2008-08-06

We report an event-related potential study investigating the neural basis of interference and facilitation in the picture-word interference paradigm with immediate overt naming. We used the high temporal resolution of the electrophysiological response to dissociate general and specific interference processes, by comparing unrelated word distractors to nonlinguistic (a row of Xs), surface feature denoting, and category member distractors. Our results first indicate that the increased naming latencies for linguistic relative to nonlinguistic distractors are because of general conflict-monitoring processes, associated with early event-related potential effects (120-220 ms) and increased activity in the anterior cingulate cortex. Next, distractors specifying a surface feature of the picture seem to facilitate its identification within the same time window, which involves widespread networks. Finally, nonlinguistic and surface feature distractors also reduced the N400 amplitude, relative to unrelated word distractors. Taken together our results support the view that several distinct processes give rise to the reaction time results often observed in picture naming.

Seagrass ecosystem trajectory depends on the relative timescales of resistance, recovery and disturbance.

PubMed

O'Brien, Katherine R; Waycott, Michelle; Maxwell, Paul; Kendrick, Gary A; Udy, James W; Ferguson, Angus J P; Kilminster, Kieryn; Scanes, Peter; McKenzie, Len J; McMahon, Kathryn; Adams, Matthew P; Samper-Villarreal, Jimena; Collier, Catherine; Lyons, Mitchell; Mumby, Peter J; Radke, Lynda; Christianen, Marjolijn J A; Dennison, William C

2017-09-18

Seagrass ecosystems are inherently dynamic, responding to environmental change across a range of scales. Habitat requirements of seagrass are well defined, but less is known about their ability to resist disturbance. Specific means of recovery after loss are particularly difficult to quantify. Here we assess the resistance and recovery capacity of 12 seagrass genera. We document four classic trajectories of degradation and recovery for seagrass ecosystems, illustrated with examples from around the world. Recovery can be rapid once conditions improve, but seagrass absence at landscape scales may persist for many decades, perpetuated by feedbacks and/or lack of seed or plant propagules to initiate recovery. It can be difficult to distinguish between slow recovery, recalcitrant degradation, and the need for a window of opportunity to trigger recovery. We propose a framework synthesizing how the spatial and temporal scales of both disturbance and seagrass response affect ecosystem trajectory and hence resilience. Copyright © 2017 Elsevier Ltd. All rights reserved.

Sequential neuromodulation of Hebbian plasticity offers mechanism for effective reward-based navigation

PubMed Central

Brzosko, Zuzanna; Zannone, Sara; Schultz, Wolfram

2017-01-01

Spike timing-dependent plasticity (STDP) is under neuromodulatory control, which is correlated with distinct behavioral states. Previously, we reported that dopamine, a reward signal, broadens the time window for synaptic potentiation and modulates the outcome of hippocampal STDP even when applied after the plasticity induction protocol (Brzosko et al., 2015). Here, we demonstrate that sequential neuromodulation of STDP by acetylcholine and dopamine offers an efficacious model of reward-based navigation. Specifically, our experimental data in mouse hippocampal slices show that acetylcholine biases STDP toward synaptic depression, whilst subsequent application of dopamine converts this depression into potentiation. Incorporating this bidirectional neuromodulation-enabled correlational synaptic learning rule into a computational model yields effective navigation toward changing reward locations, as in natural foraging behavior. Thus, temporally sequenced neuromodulation of STDP enables associations to be made between actions and outcomes and also provides a possible mechanism for aligning the time scales of cellular and behavioral learning. DOI: http://dx.doi.org/10.7554/eLife.27756.001 PMID:28691903

Pre-attentive processing of spectrally complex sounds with asynchronous onsets: an event-related potential study with human subjects.

PubMed

Tervaniemi, M; Schröger, E; Näätänen, R

1997-05-23

Neuronal mechanisms involved in the processing of complex sounds with asynchronous onsets were studied in reading subjects. The sound onset asynchrony (SOA) between the leading partial and the remaining complex tone was varied between 0 and 360 ms. Infrequently occurring deviant sounds (in which one out of 10 harmonics was different in pitch relative to the frequently occurring standard sound) elicited the mismatch negativity (MMN), a change-specific cortical event-related potential (ERP) component. This indicates that the pitch of standard stimuli had been pre-attentively coded by sensory-memory traces. Moreover, when the complex-tone onset fell within temporal integration window initiated by the leading-partial onset, the deviants elicited the N2b component. This indexes that involuntary attention switch towards the sound change occurred. In summary, the present results support the existence of pre-perceptual integration mechanism of 100-200 ms duration and emphasize its importance in switching attention towards the stimulus change.

Tunable plasmon-induced absorption effects in a graphene-based waveguide coupled with graphene ring resonators

NASA Astrophysics Data System (ADS)

Huang, Pei-Nian; Xia, Sheng-Xuan; Fu, Guang-Lai; Liang, Mei-Zhen; Qin, Meng; Zhai, Xiang; Wang, Ling-Ling

2018-03-01

In this paper, we propose a structure composed of two graphene waveguides and dual coupled graphene ring resonators (GRRs) to achieve a plasmon-induced absorption (PIA) effect. A three-level plasmonic system and a temporal coupled mode theory (CMT) are utilized to verify the simulation results. Moreover, a double-window-PIA effect can be conveniently attained by introducing another GRR with proper parameters to meet more specific acquirement in optical modulation process. The pronounced PIA resonances can be tuned in a number of ways, such as by adjusting the coupling distance between the GRRs and the couplings between the GRR and the waveguide, and tuning the radius and the Fermi energy of the GRRs. Besides, the produced PIA effect shows a high group delay up to - 1 . 87 ps, exhibiting a particularly prominent fast-light feature. Our results have potential applications in the realization of THz-integrated spectral control and graphene plasmonic devices such as sensors, filters, ultra-fast optical switches and so on.

Time-series analysis of sleep wake stage of rat EEG using time-dependent pattern entropy

NASA Astrophysics Data System (ADS)

Ishizaki, Ryuji; Shinba, Toshikazu; Mugishima, Go; Haraguchi, Hikaru; Inoue, Masayoshi

2008-05-01

We performed electroencephalography (EEG) for six male Wistar rats to clarify temporal behaviors at different levels of consciousness. Levels were identified both by conventional sleep analysis methods and by our novel entropy method. In our method, time-dependent pattern entropy is introduced, by which EEG is reduced to binary symbolic dynamics and the pattern of symbols in a sliding temporal window is considered. A high correlation was obtained between level of consciousness as measured by the conventional method and mean entropy in our entropy method. Mean entropy was maximal while awake (stage W) and decreased as sleep deepened. These results suggest that time-dependent pattern entropy may offer a promising method for future sleep research.

Rapid visual grouping and figure-ground processing using temporally structured displays.

PubMed

Cheadle, Samuel; Usher, Marius; Müller, Hermann J

2010-08-23

We examine the time course of visual grouping and figure-ground processing. Figure (contour) and ground (random-texture) elements were flickered with different phases (i.e., contour and background are alternated), requiring the observer to group information within a pre-specified time window. It was found this grouping has a high temporal resolution: less than 20ms for smooth contours, and less than 50ms for line conjunctions with sharp angles. Furthermore, the grouping process takes place without an explicit knowledge of the phase of the elements, and it requires a cumulative build-up of information. The results are discussed in relation to the neural mechanism for visual grouping and figure-ground segregation. Copyright 2010 Elsevier Ltd. All rights reserved.

Pattern Discovery and Change Detection of Online Music Query Streams

NASA Astrophysics Data System (ADS)

Li, Hua-Fu

In this paper, an efficient stream mining algorithm, called FTP-stream (Frequent Temporal Pattern mining of streams), is proposed to find the frequent temporal patterns over melody sequence streams. In the framework of our proposed algorithm, an effective bit-sequence representation is used to reduce the time and memory needed to slide the windows. The FTP-stream algorithm can calculate the support threshold in only a single pass based on the concept of bit-sequence representation. It takes the advantage of "left" and "and" operations of the representation. Experiments show that the proposed algorithm only scans the music query stream once, and runs significant faster and consumes less memory than existing algorithms, such as SWFI-stream and Moment.

Perinatal BPA exposure alters body weight and composition in a dose specific and sex specific manner: The addition of peripubertal exposure exacerbates adverse effects in female mice.

PubMed

Rubin, Beverly S; Paranjpe, Maneesha; DaFonte, Tracey; Schaeberle, Cheryl; Soto, Ana M; Obin, Martin; Greenberg, Andrew S

2017-03-01

Body weight (BW) and body composition were examined in CD-1 mice exposed perinatally or perinatally and peripubertally to 0, 0.25, 2.5, 25, or 250μg BPA/kg BW/day. Our goal was to identify the BPA dose (s) and the exposure window(s) that increased BW and adiposity, and to assess potential sex differences in this response. Both perinatal exposure alone and perinatal plus peripubertal exposure to environmentally relevant levels of BPA resulted in lasting effects on body weight and body composition. The effects were dose specific and sex specific and were influenced by the precise window of BPA exposure. The addition of peripubertal BPA exposure following the initial perinatal exposure exacerbated adverse effects in the females but appeared to reduce differences in body weight and body composition between control and BPA exposed males. Some effects of BPA on body weight and body composition showed a non-linear dose response. Copyright © 2016. Published by Elsevier Inc.

Interview with Violet Oaklander, Author of "Windows to Our Children."

ERIC Educational Resources Information Center

Campbell, Chari A.

1993-01-01

Presents interview with Dr. Violent Oaklander, experienced child therapist and author of "Windows to Our Children: A Gestalt Therapy with Children and Adolescents." Discusses critical components of successful therapy with children. Explains how developmental stage of child affects therapeutic process, and provides specific examples of working with…

Automated Measurement of P- and S-Wave Differential Times for Imaging Spatial Distributions of Vp/Vs Ratio, with Moving-Window Cross-Correlation Technique

NASA Astrophysics Data System (ADS)

Taira, T.; Kato, A.

2013-12-01

A high-resolution Vp/Vs ratio estimate is one of the key parameters to understand spatial variations of composition and physical state within the Earth. Lin and Shearer (2007, BSSA) recently developed a methodology to obtain local Vp/Vs ratios in individual similar earthquake clusters, based on P- and S-wave differential times. A waveform cross-correlation approach is typically employed to measure those differential times for pairs of seismograms from similar earthquakes clusters, at narrow time windows around the direct P and S waves. This approach effectively collects P- and S-wave differential times and however requires the robust P- and S-wave time windows that are extracted based on either manually or automatically picked P- and S-phases. We present another technique to estimate P- and S-wave differential times by exploiting temporal properties of delayed time as a function of elapsed time on the seismograms with a moving-window cross-correlation analysis (e.g., Snieder, 2002, Phys. Rev. E; Niu et al. 2003, Nature). Our approach is based on the principle that the delayed time for the direct S wave differs from that for the direct P wave. Two seismograms aligned by the direct P waves from a pair of similar earthquakes yield that delayed times become zero around the direct P wave. In contrast, delayed times obtained from time windows including the direct S wave have non-zero value. Our approach, in principle, is capable of measuring both P- and S-wave differential times from single-component seismograms. In an ideal case, the temporal evolution of delayed time becomes a step function with its discontinuity at the onset of the direct S wave. The offset in the resulting step function would be the S-wave differential time, relative to the P-wave differential time as the two waveforms are aligned by the direct P wave. We apply our moving-window cross-correlation technique to the two different data sets collected at: 1) the Wakayama district, Japan and 2) the Geysers geothermal field, California. The both target areas are characterized by earthquake swarms that provide a number of similar events clusters. We use the following automated procedure to systematically analyze the two data sets: 1) the identification of the direct P arrivals by using an Akaike Information Criterion based phase picking algorithm introduced by Zhang and Thurber (2003, BSSA), 2) the waveform alignment by the P-wave with a waveform cross-correlation to obtain P-wave differential time, 3) the moving-time window analysis to estimate the S-differential time. Kato et al. (2010, GRL) have estimated the Vp/Vs ratios for a few similar earthquake clusters from the Wakayama data set, by a conventional approach to obtain differential times. We find that the resulting Vp/Vs ratios from our approach for the same earthquake clusters are comparable with those obtained from Kato et al. (2010, GRL). We show that the moving-window cross-correlation technique effectively measures both P- and S-wave differential times for the seismograms in which the clear P and S phases are not observed. We will show spatial distributions in Vp/Vs ratios in our two target areas.

Detection of Early Ischemic Changes in Noncontrast CT Head Improved with "Stroke Windows".

PubMed

Mainali, Shraddha; Wahba, Mervat; Elijovich, Lucas

2014-01-01

Introduction. Noncontrast head CT (NCCT) is the standard radiologic test for patients presenting with acute stroke. Early ischemic changes (EIC) are often overlooked on initial NCCT. We determine the sensitivity and specificity of improved EIC detection by a standardized method of image evaluation (Stroke Windows). Methods. We performed a retrospective chart review to identify patients with acute ischemic stroke who had NCCT at presentation. EIC was defined by the presence of hyperdense MCA/basilar artery sign; sulcal effacement; basal ganglia/subcortical hypodensity; and loss of cortical gray-white differentiation. NCCT was reviewed with standard window settings and with specialized Stroke Windows. Results. Fifty patients (42% females, 58% males) with a mean NIHSS of 13.4 were identified. EIC was detected in 9 patients with standard windows, while EIC was detected using Stroke Windows in 35 patients (18% versus 70%; P < 0.0001). Hyperdense MCA sign was the most commonly reported EIC; it was better detected with Stroke Windows (14% and 36%; P < 0.0198). Detection of the remaining EIC also improved with Stroke Windows (6% and 46%; P < 0.0001). Conclusions. Detection of EIC has important implications in diagnosis and treatment of acute ischemic stroke. Utilization of Stroke Windows significantly improved detection of EIC.

Updating Landsat time series of surface-reflectance composites and forest change products with new observations

NASA Astrophysics Data System (ADS)

Hermosilla, Txomin; Wulder, Michael A.; White, Joanne C.; Coops, Nicholas C.; Hobart, Geordie W.

2017-12-01

The use of time series satellite data allows for the temporally dense, systematic, transparent, and synoptic capture of land dynamics over time. Subsequent to the opening of the Landsat archive, several time series approaches for characterizing landscape change have been developed, often representing a particular analytical time window. The information richness and widespread utility of these time series data have created a need to maintain the currency of time series information via the addition of new data, as it becomes available. When an existing time series is temporally extended, it is critical that previously generated change information remains consistent, thereby not altering reported change statistics or science outcomes based on that change information. In this research, we investigate the impacts and implications of adding additional years to an existing 29-year annual Landsat time series for forest change. To do so, we undertook a spatially explicit comparison of the 29 overlapping years of a time series representing 1984-2012, with a time series representing 1984-2016. Surface reflectance values, and presence, year, and type of change were compared. We found that the addition of years to extend the time series had minimal effect on the annual surface reflectance composites, with slight band-specific differences (r ≥ 0.1) in the final years of the original time series being updated. The area of stand replacing disturbances and determination of change year are virtually unchanged for the overlapping period between the two time-series products. Over the overlapping temporal period (1984-2012), the total area of change differs by 0.53%, equating to an annual difference in change area of 0.019%. Overall, the spatial and temporal agreement of the changes detected by both time series was 96%. Further, our findings suggest that the entire pre-existing historic time series does not need to be re-processed during the update process. Critically, given the time series change detection and update approach followed here, science outcomes or reports representing one temporal epoch can be considered stable and will not be altered when a time series is updated with newly available data.

Short-time windowed covariance: A metric for identifying non-stationary, event-related covariant cortical sites

PubMed Central

Blakely, Timothy; Ojemann, Jeffrey G.; Rao, Rajesh P.N.

2014-01-01

Background Electrocorticography (ECoG) signals can provide high spatio-temporal resolution and high signal to noise ratio recordings of local neural activity from the surface of the brain. Previous studies have shown that broad-band, spatially focal, high-frequency increases in ECoG signals are highly correlated with movement and other cognitive tasks and can be volitionally modulated. However, significant additional information may be present in inter-electrode interactions, but adding additional higher order inter-electrode interactions can be impractical from a computational aspect, if not impossible. New method In this paper we present a new method of calculating high frequency interactions between electrodes called Short-Time Windowed Covariance (STWC) that builds on mathematical techniques currently used in neural signal analysis, along with an implementation that accelerates the algorithm by orders of magnitude by leveraging commodity, off-the-shelf graphics processing unit (GPU) hardware. Results Using the hardware-accelerated implementation of STWC, we identify many types of event-related inter-electrode interactions from human ECoG recordings on global and local scales that have not been identified by previous methods. Unique temporal patterns are observed for digit flexion in both low- (10 mm spacing) and high-resolution (3 mm spacing) electrode arrays. Comparison with existing methods Covariance is a commonly used metric for identifying correlated signals, but the standard covariance calculations do not allow for temporally varying covariance. In contrast STWC allows and identifies event-driven changes in covariance without identifying spurious noise correlations. Conclusions: STWC can be used to identify event-related neural interactions whose high computational load is well suited to GPU capabilities. PMID:24211499

Insertion characteristics and placement of the Mid-Scala electrode array in human temporal bones using detailed cone beam computed tomography.

PubMed

Dietz, Aarno; Gazibegovic, Dzemal; Tervaniemi, Jyrki; Vartiainen, Veli-Matti; Löppönen, Heikki

2016-12-01

The aim of this study was to evaluate the insertion results and placement of the new Advanced Bionics HiFocus Mid-Scala (HFms) electrode array, inserted through the round window membrane, in eight fresh human temporal bones using cone beam computed tomography (CBCT). Pre- and post-insertion CBCT scans were registered to create a 3D reconstruction of the cochlea with the array inserted. With an image fusion technique both the bony edges of the cochlea and the electrode array in situ could accurately be determined, thus enabling to identify the exact position of the electrode array within the scala tympani. Vertical and horizontal scalar location was measured at four points along the cochlea base at an angular insertion depth of 90°, 180° and 270° and at electrode 16, the most basal electrode. Smooth insertion through the round window membrane was possible in all temporal bones. The imaging results showed that there were no dislocations from the scala tympani into the scala vestibule. The HFms electrode was positioned in the middle of the scala along the whole electrode array in three out of the eight bones and in 62 % of the individual locations measured along the base of the cochlea. In only one cochlea a close proximity of the electrode with the basilar membrane was observed, indicating possible contact with the basilar membrane. The results and assessments presented in this study appear to be highly accurate. Although a further validation including histopathology is needed, the image fusion technique described in this study represents currently the most accurate method for intracochlear electrode assessment obtainable with CBCT.

Crustal Fracturing Field and Presence of Fluid as Revealed by Seismic Anisotropy

NASA Astrophysics Data System (ADS)

Pastori, M.; Piccinini, D.; de Gori, P.; Margheriti, L.; Barchi, M. R.; di Bucci, D.

2010-12-01

In the last three years, we developed, tested and improved an automatic analysis code (Anisomat+) to calculate the shear wave splitting parameters, fast polarization direction (φ) and delay time (∂t). The code is a set of MatLab scripts able to retrieve crustal anisotropy parameters from three-component seismic recording of local earthquakes using horizontal component cross-correlation method. The analysis procedure consists in choosing an appropriate frequency range, that better highlights the signal containing the shear waves, and a length of time window on the seismogram centered on the S arrival (the temporal window contains at least one cycle of S wave). The code was compared to other two automatic analysis code (SPY and SHEBA) and tested on three Italian areas (Val d’Agri, Tiber Valley and L’Aquila surrounding) along the Apennine mountains. For each region we used the anisotropic parameters resulting from the automatic computation as a tool to determine the fracture field geometries connected with the active stress field. We compare the temporal variations of anisotropic parameters to the evolution of vp/vs ratio for the same seismicity. The anisotropic fast directions are used to define the active stress field (EDA model), finding a general consistence between fast direction and main stress indicators (focal mechanism and borehole break-out). The magnitude of delay time is used to define the fracture field intensity finding higher value in the volume where micro-seismicity occurs. Furthermore we studied temporal variations of anisotropic parameters and vp/vs ratio in order to explain if fluids play an important role in the earthquake generation process. The close association of anisotropic and vp/vs parameters variations and seismicity rate changes supports the hypothesis that the background seismicity is influenced by the fluctuation of pore fluid pressure in the rocks.

A Framework of Temporal-Spatial Descriptors-Based Feature Extraction for Improved Myoelectric Pattern Recognition.

PubMed

Khushaba, Rami N; Al-Timemy, Ali H; Al-Ani, Ahmed; Al-Jumaily, Adel

2017-10-01

The extraction of the accurate and efficient descriptors of muscular activity plays an important role in tackling the challenging problem of myoelectric control of powered prostheses. In this paper, we present a new feature extraction framework that aims to give an enhanced representation of muscular activities through increasing the amount of information that can be extracted from individual and combined electromyogram (EMG) channels. We propose to use time-domain descriptors (TDDs) in estimating the EMG signal power spectrum characteristics; a step that preserves the computational power required for the construction of spectral features. Subsequently, TDD is used in a process that involves: 1) representing the temporal evolution of the EMG signals by progressively tracking the correlation between the TDD extracted from each analysis time window and a nonlinearly mapped version of it across the same EMG channel and 2) representing the spatial coherence between the different EMG channels, which is achieved by calculating the correlation between the TDD extracted from the differences of all possible combinations of pairs of channels and their nonlinearly mapped versions. The proposed temporal-spatial descriptors (TSDs) are validated on multiple sparse and high-density (HD) EMG data sets collected from a number of intact-limbed and amputees performing a large number of hand and finger movements. Classification results showed significant reductions in the achieved error rates in comparison to other methods, with the improvement of at least 8% on average across all subjects. Additionally, the proposed TSDs achieved significantly well in problems with HD-EMG with average classification errors of <5% across all subjects using windows lengths of 50 ms only.

fMRI-constrained source analysis reveals early top-down modulations of interference processing using a flanker task.

PubMed

Siemann, Julia; Herrmann, Manfred; Galashan, Daniela

2016-08-01

Usually, incongruent flanker stimuli provoke conflict processing whereas congruent flankers should facilitate task performance. Various behavioral studies reported improved or even absent conflict processing with correctly oriented selective attention. In the present study we attempted to reinvestigate these behavioral effects and to disentangle neuronal activity patterns underlying the attentional cueing effect taking advantage of a combination of the high temporal resolution of Electroencephalographic (EEG) and the spatial resolution of functional magnetic resonance imaging (fMRI). Data from 20 participants were acquired in different sessions per method. We expected the conflict-related N200 event-related potential (ERP) component and areas associated with flanker processing to show validity-specific modulations. Additionally, the spatio-temporal dynamics during cued flanker processing were examined using an fMRI-constrained source analysis approach. In the ERP data we found early differences in flanker processing between validity levels. An early centro-parietal relative positivity for incongruent stimuli occurred only with valid cueing during the N200 time window, while a subsequent fronto-central negativity was specific to invalidly cued interference processing. The source analysis additionally pointed to separate neural generators of these effects. Regional sources in visual areas were involved in conflict processing with valid cueing, while a regional source in the anterior cingulate cortex (ACC) seemed to contribute to the ERP differences with invalid cueing. Moreover, the ACC and precentral gyrus demonstrated an early and a late phase of congruency-related activity differences with invalid cueing. We discuss the first effect to reflect conflict detection and response activation while the latter more likely originated from conflict monitoring and control processes during response competition. Copyright © 2016 Elsevier Inc. All rights reserved.

Specific Modifications of Histone Tails, but Not DNA Methylation, Mirror the Temporal Variation of Mammalian Recombination Hotspots

PubMed Central

Zeng, Jia; Yi, Soojin V.

2014-01-01

Recombination clusters nonuniformly across mammalian genomes at discrete genomic loci referred to as recombination hotspots. Despite their ubiquitous presence, individual hotspots rapidly lose their activities, and the molecular and evolutionary mechanisms underlying such frequent hotspot turnovers (the so-called “recombination hotspot paradox”) remain unresolved. Even though some sequence motifs are significantly associated with hotspots, multiple lines of evidence indicate that factors other than underlying sequences, such as epigenetic modifications, may affect the evolution of recombination hotspots. Thus, identifying epigenetic factors that covary with recombination at fine-scale is a promising step for this important research area. It was previously reported that recombination rates correlate with indirect measures of DNA methylation in the human genome. Here, we analyze experimentally determined DNA methylation and histone modification of human sperms, and show that the correlation between DNA methylation and recombination in long-range windows does not hold with respect to the spatial and temporal variation of recombination at hotspots. On the other hand, two histone modifications (H3K4me3 and H3K27me3) overlap extensively with recombination hotspots. Similar trends were observed in mice. These results indicate that specific histone modifications rather than DNA methylation are associated with the rapid evolution of recombination hotspots. Furthermore, many human recombination hotspots occupy “bivalent” chromatin regions that harbor both active (H3K4me3) and repressive (H3K27me3) marks. This may explain why human recombination hotspots tend to occur in nongenic regions, in contrast to yeast and Arabidopsis hotspots that are characterized by generally active chromatins. Our results highlight the dynamic epigenetic underpinnings of recombination hotspot evolution. PMID:25326136

Specific modifications of histone tails, but not DNA methylation, mirror the temporal variation of mammalian recombination hotspots.

PubMed

Zeng, Jia; Yi, Soojin V

2014-10-16

Recombination clusters nonuniformly across mammalian genomes at discrete genomic loci referred to as recombination hotspots. Despite their ubiquitous presence, individual hotspots rapidly lose their activities, and the molecular and evolutionary mechanisms underlying such frequent hotspot turnovers (the so-called "recombination hotspot paradox") remain unresolved. Even though some sequence motifs are significantly associated with hotspots, multiple lines of evidence indicate that factors other than underlying sequences, such as epigenetic modifications, may affect the evolution of recombination hotspots. Thus, identifying epigenetic factors that covary with recombination at fine-scale is a promising step for this important research area. It was previously reported that recombination rates correlate with indirect measures of DNA methylation in the human genome. Here, we analyze experimentally determined DNA methylation and histone modification of human sperms, and show that the correlation between DNA methylation and recombination in long-range windows does not hold with respect to the spatial and temporal variation of recombination at hotspots. On the other hand, two histone modifications (H3K4me3 and H3K27me3) overlap extensively with recombination hotspots. Similar trends were observed in mice. These results indicate that specific histone modifications rather than DNA methylation are associated with the rapid evolution of recombination hotspots. Furthermore, many human recombination hotspots occupy "bivalent" chromatin regions that harbor both active (H3K4me3) and repressive (H3K27me3) marks. This may explain why human recombination hotspots tend to occur in nongenic regions, in contrast to yeast and Arabidopsis hotspots that are characterized by generally active chromatins. Our results highlight the dynamic epigenetic underpinnings of recombination hotspot evolution. © The Author(s) 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

Investigation of Magnetotelluric Source Effect Based on Twenty Years of Telluric and Geomagnetic Observation

NASA Astrophysics Data System (ADS)

Kis, A.; Lemperger, I.; Wesztergom, V.; Menvielle, M.; Szalai, S.; Novák, A.; Hada, T.; Matsukiyo, S.; Lethy, A. M.

2016-12-01

Magnetotelluric method is widely applied for investigation of subsurface structures by imaging the spatial distribution of electric conductivity. The method is based on the experimental determination of surface electromagnetic impedance tensor (Z) by surface geomagnetic and telluric registrations in two perpendicular orientation. In practical explorations the accurate estimation of Z necessitates the application of robust statistical methods for two reasons:1) the geomagnetic and telluric time series' are contaminated by man-made noise components and2) the non-homogeneous behavior of ionospheric current systems in the period range of interest (ELF-ULF and longer periods) results in systematic deviation of the impedance of individual time windows.Robust statistics manage both load of Z for the purpose of subsurface investigations. However, accurate analysis of the long term temporal variation of the first and second statistical moments of Z may provide valuable information about the characteristics of the ionospheric source current systems. Temporal variation of extent, spatial variability and orientation of the ionospheric source currents has specific effects on the surface impedance tensor. Twenty year long geomagnetic and telluric recordings of the Nagycenk Geophysical Observatory provides unique opportunity to reconstruct the so called magnetotelluric source effect and obtain information about the spatial and temporal behavior of ionospheric source currents at mid-latitudes. Detailed investigation of time series of surface electromagnetic impedance tensor has been carried out in different frequency classes of the ULF range. The presentation aims to provide a brief review of our results related to long term periodic modulations, up to solar cycle scale and about eventual deviations of the electromagnetic impedance and so the reconstructed equivalent ionospheric source effects.

Defining window-boundaries for genomic analyses using smoothing spline techniques

DOE PAGES

Beissinger, Timothy M.; Rosa, Guilherme J.M.; Kaeppler, Shawn M.; ...

2015-04-17

High-density genomic data is often analyzed by combining information over windows of adjacent markers. Interpretation of data grouped in windows versus at individual locations may increase statistical power, simplify computation, reduce sampling noise, and reduce the total number of tests performed. However, use of adjacent marker information can result in over- or under-smoothing, undesirable window boundary specifications, or highly correlated test statistics. We introduce a method for defining windows based on statistically guided breakpoints in the data, as a foundation for the analysis of multiple adjacent data points. This method involves first fitting a cubic smoothing spline to the datamore » and then identifying the inflection points of the fitted spline, which serve as the boundaries of adjacent windows. This technique does not require prior knowledge of linkage disequilibrium, and therefore can be applied to data collected from individual or pooled sequencing experiments. Moreover, in contrast to existing methods, an arbitrary choice of window size is not necessary, since these are determined empirically and allowed to vary along the genome.« less

Design and Verification of Critical Pressurised Windows for Manned Spaceflight

NASA Astrophysics Data System (ADS)

Lamoure, Richard; Busto, Lara; Novo, Francisco; Sinnema, Gerben; Leal, Mendes M.

2014-06-01

The Window Design for Manned Spaceflight (WDMS) project was tasked with establishing the state-of-art and explore possible improvements to the current structural integrity verification and fracture control methodologies for manned spacecraft windows.A critical review of the state-of-art in spacecraft window design, materials and verification practice was conducted. Shortcomings of the methodology in terms of analysis, inspection and testing were identified. Schemes for improving verification practices and reducing conservatism whilst maintaining the required safety levels were then proposed.An experimental materials characterisation programme was defined and carried out with the support of the 'Glass and Façade Technology Research Group', at the University of Cambridge. Results of the sample testing campaign were analysed, post-processed and subsequently applied to the design of a breadboard window demonstrator.Two Fused Silica glass window panes were procured and subjected to dedicated analyses, inspection and testing comprising both qualification and acceptance programmes specifically tailored to the objectives of the activity.Finally, main outcomes have been compiled into a Structural Verification Guide for Pressurised Windows in manned spacecraft, incorporating best practices and lessons learned throughout this project.

Probabilistic assessment of phenophase-wise agricultural drought risk under different sowing windows: a case study with rainfed soybean.

PubMed

Dhakar, Rajkumar; Sarath Chandran, M A; Nagar, Shivani; Visha Kumari, V

2017-11-23

A new methodology for crop-growth stage-specific assessment of agricultural drought risk under a variable sowing window is proposed for the soybean crop. It encompasses three drought indices, which include Crop-Specific Drought Index (CSDI), Vegetation Condition Index (VCI), and Standardized Precipitation Evapotranspiration Index (SPEI). The unique features of crop-growth stage-specific nature and spatial and multi-scalar coverage provide a comprehensive assessment of agricultural drought risk. This study was conducted in 10 major soybean-growing districts of Madhya Pradesh state of India. These areas contribute about 60% of the total soybean production for the country. The phenophase most vulnerable to agricultural drought was identified (germination and flowering in our case) for each district across four sowing windows. The agricultural drought risk was quantified at various severity levels (moderate, severe, and very severe) for each growth stage and sowing window. Validation of the proposed new methodology also yielded results with a high correlation coefficient between percent probability of agricultural drought risk and yield risk (r = 0.92). Assessment by proximity matrix yielded a similar statistic. Expectations for the proposed methodology are better mitigation-oriented management and improved crop contingency plans for planners and decision makers.

Computed Tomography Window Blending: Feasibility in Thoracic Trauma.

PubMed

Mandell, Jacob C; Wortman, Jeremy R; Rocha, Tatiana C; Folio, Les R; Andriole, Katherine P; Khurana, Bharti

2018-02-07

This study aims to demonstrate the feasibility of processing computed tomography (CT) images with a custom window blending algorithm that combines soft-tissue, bone, and lung window settings into a single image; to compare the time for interpretation of chest CT for thoracic trauma with window blending and conventional window settings; and to assess diagnostic performance of both techniques. Adobe Photoshop was scripted to process axial DICOM images from retrospective contrast-enhanced chest CTs performed for trauma with a window-blending algorithm. Two emergency radiologists independently interpreted the axial images from 103 chest CTs with both blended and conventional windows. Interpretation time and diagnostic performance were compared with Wilcoxon signed-rank test and McNemar test, respectively. Agreement with Nexus CT Chest injury severity was assessed with the weighted kappa statistic. A total of 13,295 images were processed without error. Interpretation was faster with window blending, resulting in a 20.3% time saving (P < .001), with no difference in diagnostic performance, within the power of the study to detect a difference in sensitivity of 5% as determined by post hoc power analysis. The sensitivity of the window-blended cases was 82.7%, compared to 81.6% for conventional windows. The specificity of the window-blended cases was 93.1%, compared to 90.5% for conventional windows. All injuries of major clinical significance (per Nexus CT Chest criteria) were correctly identified in all reading sessions, and all negative cases were correctly classified. All readers demonstrated near-perfect agreement with injury severity classification with both window settings. In this pilot study utilizing retrospective data, window blending allows faster preliminary interpretation of axial chest CT performed for trauma, with no significant difference in diagnostic performance compared to conventional window settings. Future studies would be required to assess the utility of window blending in clinical practice. Copyright © 2018 The Association of University Radiologists. All rights reserved.

Optical performance of segmented aperture windows for solar tower receivers

NASA Astrophysics Data System (ADS)

Buck, Reiner

2017-06-01

Segmented quartz windows are a concept to build larger windows for receivers that require a closed aperture. Reflection losses are a significant loss factor for such solar receivers. Without any additional measures, the reflection loss can reach about 12%. One important measure to improve transmission is the application of anti-reflective coatings, which is beneficial in any case. Another option is modifying the window geometry, especially the edge surfaces of the glass segments. A certain fraction of the reflection losses are caused by a light-guide effect in the glass body, for rays entering through the front surface. Changing the cut surfaces in a way reducing the light-guide effect can significantly improve transmission of a segmented window. Several possible configurations are evaluated and discussed. The results of ray-tracing simulations verify the improvement. The final selection of the window configuration depends on the optical properties and on mechanical strength, manufacturing and cost considerations. This has to be evaluated for any specific receiver design.

Idealized Computational Models for Auditory Receptive Fields

PubMed Central

Lindeberg, Tony; Friberg, Anders

2015-01-01

We present a theory by which idealized models of auditory receptive fields can be derived in a principled axiomatic manner, from a set of structural properties to (i) enable invariance of receptive field responses under natural sound transformations and (ii) ensure internal consistency between spectro-temporal receptive fields at different temporal and spectral scales. For defining a time-frequency transformation of a purely temporal sound signal, it is shown that the framework allows for a new way of deriving the Gabor and Gammatone filters as well as a novel family of generalized Gammatone filters, with additional degrees of freedom to obtain different trade-offs between the spectral selectivity and the temporal delay of time-causal temporal window functions. When applied to the definition of a second-layer of receptive fields from a spectrogram, it is shown that the framework leads to two canonical families of spectro-temporal receptive fields, in terms of spectro-temporal derivatives of either spectro-temporal Gaussian kernels for non-causal time or a cascade of time-causal first-order integrators over the temporal domain and a Gaussian filter over the logspectral domain. For each filter family, the spectro-temporal receptive fields can be either separable over the time-frequency domain or be adapted to local glissando transformations that represent variations in logarithmic frequencies over time. Within each domain of either non-causal or time-causal time, these receptive field families are derived by uniqueness from the assumptions. It is demonstrated how the presented framework allows for computation of basic auditory features for audio processing and that it leads to predictions about auditory receptive fields with good qualitative similarity to biological receptive fields measured in the inferior colliculus (ICC) and primary auditory cortex (A1) of mammals. PMID:25822973

Two stages of directed forgetting: Electrophysiological evidence from a short-term memory task.

PubMed

Gao, Heming; Cao, Bihua; Qi, Mingming; Wang, Jing; Zhang, Qi; Li, Fuhong

2016-06-01

In this study, a short-term memory test was used to investigate the temporal course and neural mechanism of directed forgetting under different memory loads. Within each trial, two memory items with high or low load were presented sequentially, followed by a cue indicating whether the presented items should be remembered. After an interval, subjects were asked to respond to the probe stimuli. The ERPs locked to the cues showed that (a) the effect of cue type was initially observed during the P2 (160-240 ms) time window, with more positive ERPs for remembering relative to forgetting cues; (b) load effects were observed during the N2-P3 (250-500 ms) time window, with more positive ERPs for the high-load than low-load condition; (c) the cue effect was also observed during the N2-P3 time window, with more negative ERPs for forgetting versus remembering cues. These results demonstrated that directed forgetting involves two stages: task-relevance identification and information discarding. The cue effects during the N2 epoch supported the view that directed forgetting is an active process. © 2016 Society for Psychophysiological Research.

Hydrocarbon Reservoir Prediction Using Bi-Gaussian S Transform Based Time-Frequency Analysis Approach

NASA Astrophysics Data System (ADS)

Cheng, Z.; Chen, Y.; Liu, Y.; Liu, W.; Zhang, G.

2015-12-01

Among those hydrocarbon reservoir detection techniques, the time-frequency analysis based approach is one of the most widely used approaches because of its straightforward indication of low-frequency anomalies from the time-frequency maps, that is to say, the low-frequency bright spots usually indicate the potential hydrocarbon reservoirs. The time-frequency analysis based approach is easy to implement, and more importantly, is usually of high fidelity in reservoir prediction, compared with the state-of-the-art approaches, and thus is of great interest to petroleum geologists, geophysicists, and reservoir engineers. The S transform has been frequently used in obtaining the time-frequency maps because of its better performance in controlling the compromise between the time and frequency resolutions than the alternatives, such as the short-time Fourier transform, Gabor transform, and continuous wavelet transform. The window function used in the majority of previous S transform applications is the symmetric Gaussian window. However, one problem with the symmetric Gaussian window is the degradation of time resolution in the time-frequency map due to the long front taper. In our study, a bi-Gaussian S transform that substitutes the symmetric Gaussian window with an asymmetry bi-Gaussian window is proposed to analyze the multi-channel seismic data in order to predict hydrocarbon reservoirs. The bi-Gaussian window introduces asymmetry in the resultant time-frequency spectrum, with time resolution better in the front direction, as compared with the back direction. It is the first time that the bi-Gaussian S transform is used for analyzing multi-channel post-stack seismic data in order to predict hydrocarbon reservoirs since its invention in 2003. The superiority of the bi-Gaussian S transform over traditional S transform is tested on a real land seismic data example. The performance shows that the enhanced temporal resolution can help us depict more clearly the edge of the hydrocarbon reservoir, especially when the thickness of the reservoir is small (such as the thin beds).

Proper Installation of Replacement Windows | Efficient Windows

Science.gov Websites

. Quality installation is critical for an airtight fit and a continuous water barrier to prevent drafts , water damage and condensation. The complexity of the installation depends on whether you are considering and specifications. Install level, plumb, and square. Install water tight: water must be prevented

Continuous tamoxifen delivery improves locomotor recovery 6h after spinal cord injury by neuronal and glial mechanisms in male rats.

PubMed

Colón, Jennifer M; González, Pablo A; Cajigas, Ámbar; Maldonado, Wanda I; Torrado, Aranza I; Santiago, José M; Salgado, Iris K; Miranda, Jorge D

2018-01-01

No treatment is available for patients with spinal cord injury (SCI). Patients often arrive to the hospital hours after SCI suggesting the need of a therapy that can be used on a clinically relevant window. Previous studies showed that Tamoxifen (TAM) treatment 24h after SCI benefits locomotor recovery in female rats. Tamoxifen exerts beneficial effects in male and female rodents but a gap of knowledge exists on: the therapeutic window of TAM, the spatio-temporal mechanisms activated and if this response is sexually dimorphic. We hypothesized that TAM will favor locomotor recovery when administered up-to 24h after SCI in male Sprague-Dawley rats. Rats received a thoracic (T10) contusion using the MACSIS impactor followed by placebo or TAM (15mg/21days) pellets in a therapeutic window of 0, 6, 12, or 24h. Animals were sacrificed at 2, 7, 14, 28 or 35days post injury (DPI) to study the molecular and cellular changes in the acute and chronic stages. Immediate or delayed therapy (t=6h) improved locomotor function, increased white matter spared tissue, and neuronal survival. TAM reduced reactive gliosis during chronic stages and increased the expression of Olig-2. A significant difference was observed in estrogen receptor alpha between male and female rodents from 2 to 28 DPI suggesting a sexually dimorphic characteristic that could be related to the behavioral differences observed in the therapeutic window of TAM. This study supports the use of TAM in the SCI setting due to its neuroprotective effects but with a significant sexually dimorphic therapeutic window. Copyright © 2017 Elsevier Inc. All rights reserved.

Egocentric Temporal Action Proposals.

PubMed

Shao Huang; Weiqiang Wang; Shengfeng He; Lau, Rynson W H

2018-02-01

We present an approach to localize generic actions in egocentric videos, called temporal action proposals (TAPs), for accelerating the action recognition step. An egocentric TAP refers to a sequence of frames that may contain a generic action performed by the wearer of a head-mounted camera, e.g., taking a knife, spreading jam, pouring milk, or cutting carrots. Inspired by object proposals, this paper aims at generating a small number of TAPs, thereby replacing the popular sliding window strategy, for localizing all action events in the input video. To this end, we first propose to temporally segment the input video into action atoms, which are the smallest units that may contain an action. We then apply a hierarchical clustering algorithm with several egocentric cues to generate TAPs. Finally, we propose two actionness networks to score the likelihood of each TAP containing an action. The top ranked candidates are returned as output TAPs. Experimental results show that the proposed TAP detection framework performs significantly better than relevant approaches for egocentric action detection.

Uncovering effects of self-control and stimulus-driven action selection on the sense of agency.

PubMed

Wang, Yuru; Damen, Tom G E; Aarts, Henk

2017-10-01

The sense of agency refers to feelings of causing one's own action and resulting effect. Previous research indicates that voluntary action selection is an important factor in shaping the sense of agency. Whereas the volitional nature of the sense of agency is well documented, the present study examined whether agency is modulated when action selection shifts from self-control to a more automatic stimulus-driven process. Seventy-two participants performed an auditory Simon task including congruent and incongruent trials to generate automatic stimulus-driven vs. more self-control driven action, respectively. Responses in the Simon task produced a tone and agency was assessed with the intentional binding task - an implicit measure of agency. Results showed a Simon effect and temporal binding effect. However, temporal binding was independent of congruency. These findings suggest that temporal binding, a window to the sense of agency, emerges for both automatic stimulus-driven actions and self-controlled actions. Copyright © 2017 Elsevier Inc. All rights reserved.

Using Aoristic Analysis to Link Remote and Ground-Level Phenological Observations

NASA Astrophysics Data System (ADS)

Henebry, G. M.

2013-12-01

Phenology is about observing events in time and space. With the advent of publically accessible geospatial datastreams and easy to use mapping software, specifying where an event occurs is much less of a challenge than it was just two decades ago. In contrast, specifying when an event occurs remains a nontrivial function of a population of organismal responses, sampling interval, compositing period, and reporting precision. I explore how aoristic analysis can be used to analyzing spatiotemporal events for which the location is known to acceptable levels of precision but for which temporal coordinates are poorly specified or only partially bounded. Aoristic analysis was developed in the late 1990s in the field of quantitative criminology to leverage temporally imprecise geospatial data of crime reports. Here I demonstrate how aoristic analysis can be used to link remotely sensed observations of land surface phenology to ground-level observations of organismal phenophase transitions. Explicit representation of the windows of temporal uncertainty with aoristic weights enables cross-validation exercises and forecasting efforts to avoid false precision.

Studying Titan's surface photometry in the 5 microns atmospheric window with the Cassini/VIMS instrument

NASA Astrophysics Data System (ADS)

Cornet, T.; Altobelli, N.; Sotin, C.; Le Mouelic, S.; Rodriguez, S.; Philippe, S.; Brown, R. H.; Barnes, J. W.; Buratti, B. J.; Baines, K. H.; Clark, R. N.; Nicholson, P. D.

2014-12-01

Due to the influence of methane gas and a thick aerosols haze in the atmosphere, Titan's surface is only visible in 7 spectral atmospheric windows centered at 0.93, 1.08, 1.27, 1.59, 2.01, 2.7-2.8 and 5 microns with the Cassini Visual and Infrared Mapping Spectrometer (VIMS). The 5 microns atmospheric window constitutes the only one being almost insensitive to the haze scattering and which presents only a reduced atmospheric absorption contribution to the signal recorded by the instrument. Despite these advantages leading to the almost direct view of the surface, the 5 microns window is also the noisiest spectral window of the entire VIMS spectrum (an effect highly dependent on the time exposure used for the observations), and it is not totally free from atmospheric contributions, enough to keep "artefacts" in mosaics of several thousands of cubes due to atmospheric and surface photometric effects amplified by the very heterogeneous viewing conditions between each Titan flyby. At first order, a lambertian surface photometry at 5 microns has been used as an initial parameter in order to estimate atmospheric opacity and surface photometry in all VIMS atmospheric windows and to determine the albedo of the surface, yet unknown, both using radiative transfer codes on single cubes or empirical techniques on global hyperspectral mosaics. Other studies suggested that Titan's surface photometry would not be uniquely lambertian but would also contain anisotropic lunar-like contributions. In the present work, we aim at constraining accurately the surface photometry of Titan and residual atmospheric absorption effects in this 5 microns window using a comprehensive study of relevant sites located at various latitudes. Those include bright and dark (dunes) terrains, 5-microns bright terrains (Hotei Regio and Tui Regio), the Huygens Landing Site and high latitudes polar lakes and seas. The VIMS 2004 to 2014 database, composed of more than 40,000 hyperspectral cubes acquired on Titan, has been decomposed into a MySQL relational database in order to perform the present study looking at both spatial and temporal (seasonal) aspects.

Spatio-temporal Granger causality: a new framework

PubMed Central

Luo, Qiang; Lu, Wenlian; Cheng, Wei; Valdes-Sosa, Pedro A.; Wen, Xiaotong; Ding, Mingzhou; Feng, Jianfeng

2015-01-01

That physiological oscillations of various frequencies are present in fMRI signals is the rule, not the exception. Herein, we propose a novel theoretical framework, spatio-temporal Granger causality, which allows us to more reliably and precisely estimate the Granger causality from experimental datasets possessing time-varying properties caused by physiological oscillations. Within this framework, Granger causality is redefined as a global index measuring the directed information flow between two time series with time-varying properties. Both theoretical analyses and numerical examples demonstrate that Granger causality is a monotonically increasing function of the temporal resolution used in the estimation. This is consistent with the general principle of coarse graining, which causes information loss by smoothing out very fine-scale details in time and space. Our results confirm that the Granger causality at the finer spatio-temporal scales considerably outperforms the traditional approach in terms of an improved consistency between two resting-state scans of the same subject. To optimally estimate the Granger causality, the proposed theoretical framework is implemented through a combination of several approaches, such as dividing the optimal time window and estimating the parameters at the fine temporal and spatial scales. Taken together, our approach provides a novel and robust framework for estimating the Granger causality from fMRI, EEG, and other related data. PMID:23643924

Fitting model-based psychometric functions to simultaneity and temporal-order judgment data: MATLAB and R routines.

PubMed

Alcalá-Quintana, Rocío; García-Pérez, Miguel A

2013-12-01

Research on temporal-order perception uses temporal-order judgment (TOJ) tasks or synchrony judgment (SJ) tasks in their binary SJ2 or ternary SJ3 variants. In all cases, two stimuli are presented with some temporal delay, and observers judge the order of presentation. Arbitrary psychometric functions are typically fitted to obtain performance measures such as sensitivity or the point of subjective simultaneity, but the parameters of these functions are uninterpretable. We describe routines in MATLAB and R that fit model-based functions whose parameters are interpretable in terms of the processes underlying temporal-order and simultaneity judgments and responses. These functions arise from an independent-channels model assuming arrival latencies with exponential distributions and a trichotomous decision space. Different routines fit data separately for SJ2, SJ3, and TOJ tasks, jointly for any two tasks, or also jointly for the three tasks (for common cases in which two or even the three tasks were used with the same stimuli and participants). Additional routines provide bootstrap p-values and confidence intervals for estimated parameters. A further routine is included that obtains performance measures from the fitted functions. An R package for Windows and source code of the MATLAB and R routines are available as Supplementary Files.

The temporal program of chromosome replication: genomewide replication in clb5{Delta} Saccharomyces cerevisiae.

PubMed

McCune, Heather J; Danielson, Laura S; Alvino, Gina M; Collingwood, David; Delrow, Jeffrey J; Fangman, Walton L; Brewer, Bonita J; Raghuraman, M K

2008-12-01

Temporal regulation of origin activation is widely thought to explain the pattern of early- and late-replicating domains in the Saccharomyces cerevisiae genome. Recently, single-molecule analysis of replication suggested that stochastic processes acting on origins with different probabilities of activation could generate the observed kinetics of replication without requiring an underlying temporal order. To distinguish between these possibilities, we examined a clb5Delta strain, where origin firing is largely limited to the first half of S phase, to ask whether all origins nonspecifically show decreased firing (as expected for disordered firing) or if only some origins ("late" origins) are affected. Approximately half the origins in the mutant genome show delayed replication while the remainder replicate largely on time. The delayed regions can encompass hundreds of kilobases and generally correspond to regions that replicate late in wild-type cells. Kinetic analysis of replication in wild-type cells reveals broad windows of origin firing for both early and late origins. Our results are consistent with a temporal model in which origins can show some heterogeneity in both time and probability of origin firing, but clustering of temporally like origins nevertheless yields a genome that is organized into blocks showing different replication times.

Statistical analysis of data and modeling of Nanodust measured by STEREO/WAVES at 1AU

NASA Astrophysics Data System (ADS)

Belheouane, S.; Zaslavsky, A.; Meyer-Vernet, N.; Issautier, K.; Czechowski, A.; Mann, I.; Le Chat, G.; Zouganelis, I.; Maksimovic, M.

2012-12-01

We study the flux of dust particles of nanometer size measured at 1AU by the S/WAVES instrument aboard the twin STEREO spacecraft. When they impact the spacecraft at very high speed, these nanodust particles, first detected by Meyer-Vernet et al. (2009), generate plasma clouds and produce voltage pulses measured by the electric antennas. The Time Domain Sampler (TDS) of the radio and plasma instrument produces temporal windows containing several pulses. We perform a statistical study of the distribution of pulse amplitudes and arrival times in the measuring window during the 2007-2012 period. We interpret the results using simulations of the dynamics of nanodust in the solar wind based on the model of Czechowski and Mann (2010). We also investigate the variations of nanodust fluxes while STEREO rotates about the sunward axis (Roll) ; this reveals that some directions are privilegied.

Long-term optical stimulation of channelrhodopsin-expressing neurons to study network plasticity

PubMed Central

Lignani, Gabriele; Ferrea, Enrico; Difato, Francesco; Amarù, Jessica; Ferroni, Eleonora; Lugarà, Eleonora; Espinoza, Stefano; Gainetdinov, Raul R.; Baldelli, Pietro; Benfenati, Fabio

2013-01-01

Neuronal plasticity produces changes in excitability, synaptic transmission, and network architecture in response to external stimuli. Network adaptation to environmental conditions takes place in time scales ranging from few seconds to days, and modulates the entire network dynamics. To study the network response to defined long-term experimental protocols, we setup a system that combines optical and electrophysiological tools embedded in a cell incubator. Primary hippocampal neurons transduced with lentiviruses expressing channelrhodopsin-2/H134R were subjected to various photostimulation protocols in a time window in the order of days. To monitor the effects of light-induced gating of network activity, stimulated transduced neurons were simultaneously recorded using multi-electrode arrays (MEAs). The developed experimental model allows discerning short-term, long-lasting, and adaptive plasticity responses of the same neuronal network to distinct stimulation frequencies applied over different temporal windows. PMID:23970852

A Search for Neutrino Emission from Fast Radio Bursts with Six Years of IceCube Data

NASA Astrophysics Data System (ADS)

Aartsen, M. G.; Ackermann, M.; Adams, J.; Aguilar, J. A.; Ahlers, M.; Ahrens, M.; Samarai, I. Al; Altmann, D.; Andeen, K.; Anderson, T.; Ansseau, I.; Anton, G.; Argüelles, C.; Auffenberg, J.; Axani, S.; Bagherpour, H.; Bai, X.; Barron, J. P.; Barwick, S. W.; Baum, V.; Bay, R.; Beatty, J. J.; Becker Tjus, J.; Becker, K.-H.; BenZvi, S.; Berley, D.; Bernardini, E.; Besson, D. Z.; Binder, G.; Bindig, D.; Blaufuss, E.; Blot, S.; Bohm, C.; Börner, M.; Bos, F.; Böser, S.; Botner, O.; Bourbeau, E.; Bourbeau, J.; Bradascio, F.; Braun, J.; Brenzke, M.; Bretz, H.-P.; Bron, S.; Brostean-Kaiser, J.; Burgman, A.; Busse, R. S.; Carver, T.; Cheung, E.; Chirkin, D.; Christov, A.; Clark, K.; Classen, L.; Collin, G. H.; Conrad, J. M.; Coppin, P.; Correa, P.; Cowen, D. F.; Cross, R.; Dave, P.; Day, M.; de André, J. P. A. M.; De Clercq, C.; DeLaunay, J. J.; Dembinski, H.; De Ridder, S.; Desiati, P.; de Vries, K. D.; de Wasseige, G.; de With, M.; DeYoung, T.; Díaz-Vélez, J. C.; di Lorenzo, V.; Dujmovic, H.; Dumm, J. P.; Dunkman, M.; Dvorak, E.; Eberhardt, B.; Ehrhardt, T.; Eichmann, B.; Eller, P.; Evenson, P. A.; Fahey, S.; Fazely, A. R.; Felde, J.; Filimonov, K.; Finley, C.; Flis, S.; Franckowiak, A.; Friedman, E.; Fritz, A.; Gaisser, T. K.; Gallagher, J.; Gerhardt, L.; Ghorbani, K.; Giang, W.; Glauch, T.; Glüsenkamp, T.; Goldschmidt, A.; Gonzalez, J. G.; Grant, D.; Griffith, Z.; Haack, C.; Hallgren, A.; Halzen, F.; Hanson, K.; Hebecker, D.; Heereman, D.; Helbing, K.; Hellauer, R.; Hickford, S.; Hignight, J.; Hill, G. C.; Hoffman, K. D.; Hoffmann, R.; Hoinka, T.; Hokanson-Fasig, B.; Hoshina, K.; Huang, F.; Huber, M.; Hultqvist, K.; Hünnefeld, M.; Hussain, R.; In, S.; Iovine, N.; Ishihara, A.; Jacobi, E.; Japaridze, G. S.; Jeong, M.; Jero, K.; Jones, B. J. P.; Kalaczynski, P.; Kang, W.; Kappes, A.; Kappesser, D.; Karg, T.; Karle, A.; Katz, U.; Kauer, M.; Keivani, A.; Kelley, J. L.; Kheirandish, A.; Kim, J.; Kim, M.; Kintscher, T.; Kiryluk, J.; Kittler, T.; Klein, S. R.; Koirala, R.; Kolanoski, H.; Köpke, L.; Kopper, C.; Kopper, S.; Koschinsky, J. P.; Koskinen, D. J.; Kowalski, M.; Krings, K.; Kroll, M.; Krückl, G.; Kunwar, S.; Kurahashi, N.; Kuwabara, T.; Kyriacou, A.; Labare, M.; Lanfranchi, J. L.; Larson, M. J.; Lauber, F.; Leonard, K.; Lesiak-Bzdak, M.; Leuermann, M.; Liu, Q. R.; Lozano Mariscal, C. J.; Lu, L.; Lünemann, J.; Luszczak, W.; Madsen, J.; Maggi, G.; Mahn, K. B. M.; Mancina, S.; Maruyama, R.; Mase, K.; Maunu, R.; Meagher, K.; Medici, M.; Meier, M.; Menne, T.; Merino, G.; Meures, T.; Miarecki, S.; Micallef, J.; Momenté, G.; Montaruli, T.; Moore, R. W.; Moulai, M.; Nahnhauer, R.; Nakarmi, P.; Naumann, U.; Neer, G.; Niederhausen, H.; Nowicki, S. C.; Nygren, D. R.; Obertacke Pollmann, A.; Olivas, A.; O’Murchadha, A.; O’Sullivan, E.; Palczewski, T.; Pandya, H.; Pankova, D. V.; Peiffer, P.; Pepper, J. A.; Pérez de los Heros, C.; Pieloth, D.; Pinat, E.; Plum, M.; Price, P. B.; Przybylski, G. T.; Raab, C.; Rädel, L.; Rameez, M.; Rauch, L.; Rawlins, K.; Rea, I. C.; Reimann, R.; Relethford, B.; Relich, M.; Resconi, E.; Rhode, W.; Richman, M.; Robertson, S.; Rongen, M.; Rott, C.; Ruhe, T.; Ryckbosch, D.; Rysewyk, D.; Safa, I.; Sälzer, T.; Sanchez Herrera, S. E.; Sandrock, A.; Sandroos, J.; Santander, M.; Sarkar, S.; Sarkar, S.; Satalecka, K.; Schlunder, P.; Schmidt, T.; Schneider, A.; Schoenen, S.; Schöneberg, S.; Schumacher, L.; Sclafani, S.; Seckel, D.; Seunarine, S.; Soedingrekso, J.; Soldin, D.; Song, M.; Spiczak, G. M.; Spiering, C.; Stachurska, J.; Stamatikos, M.; Stanev, T.; Stasik, A.; Stein, R.; Stettner, J.; Steuer, A.; Stezelberger, T.; Stokstad, R. G.; Stößl, A.; Strotjohann, N. L.; Stuttard, T.; Sullivan, G. W.; Sutherland, M.; Taboada, I.; Tatar, J.; Tenholt, F.; Ter-Antonyan, S.; Terliuk, A.; Tilav, S.; Toale, P. A.; Tobin, M. N.; Tönnis, C.; Toscano, S.; Tosi, D.; Tselengidou, M.; Tung, C. F.; Turcati, A.; Turley, C. F.; Ty, B.; Unger, E.; Usner, M.; Vandenbroucke, J.; Van Driessche, W.; van Eijk, D.; van Eijndhoven, N.; Vanheule, S.; van Santen, J.; Vogel, E.; Vraeghe, M.; Walck, C.; Wallace, A.; Wallraff, M.; Wandler, F. D.; Wandkowsky, N.; Waza, A.; Weaver, C.; Weiss, M. J.; Wendt, C.; Werthebach, J.; Westerhoff, S.; Whelan, B. J.; Wiebe, K.; Wiebusch, C. H.; Wille, L.; Williams, D. R.; Wills, L.; Wolf, M.; Wood, J.; Wood, T. R.; Woolsey, E.; Woschnagg, K.; Xu, D. L.; Xu, X. W.; Xu, Y.; Yanez, J. P.; Yodh, G.; Yoshida, S.; Yuan, T.; IceCube Collaboration

2018-04-01

We present a search for coincidence between IceCube TeV neutrinos and fast radio bursts (FRBs). During the search period from 2010 May 31 to 2016 May 12, a total of 29 FRBs with 13 unique locations have been detected in the whole sky. An unbinned maximum likelihood method was used to search for spatial and temporal coincidence between neutrinos and FRBs in expanding time windows, in both the northern and southern hemispheres. No significant correlation was found in six years of IceCube data. Therefore, we set upper limits on neutrino fluence emitted by FRBs as a function of time window duration. We set the most stringent limit obtained to date on neutrino fluence from FRBs with an E ‑2 energy spectrum assumed, which is 0.0021 GeV cm‑2 per burst for emission timescales up to ∼102 s from the northern hemisphere stacking search.

Long-term optical stimulation of channelrhodopsin-expressing neurons to study network plasticity.

PubMed

Lignani, Gabriele; Ferrea, Enrico; Difato, Francesco; Amarù, Jessica; Ferroni, Eleonora; Lugarà, Eleonora; Espinoza, Stefano; Gainetdinov, Raul R; Baldelli, Pietro; Benfenati, Fabio

2013-01-01

Neuronal plasticity produces changes in excitability, synaptic transmission, and network architecture in response to external stimuli. Network adaptation to environmental conditions takes place in time scales ranging from few seconds to days, and modulates the entire network dynamics. To study the network response to defined long-term experimental protocols, we setup a system that combines optical and electrophysiological tools embedded in a cell incubator. Primary hippocampal neurons transduced with lentiviruses expressing channelrhodopsin-2/H134R were subjected to various photostimulation protocols in a time window in the order of days. To monitor the effects of light-induced gating of network activity, stimulated transduced neurons were simultaneously recorded using multi-electrode arrays (MEAs). The developed experimental model allows discerning short-term, long-lasting, and adaptive plasticity responses of the same neuronal network to distinct stimulation frequencies applied over different temporal windows.

Estimating interevent time distributions from finite observation periods in communication networks

NASA Astrophysics Data System (ADS)

Kivelä, Mikko; Porter, Mason A.

2015-11-01

A diverse variety of processes—including recurrent disease episodes, neuron firing, and communication patterns among humans—can be described using interevent time (IET) distributions. Many such processes are ongoing, although event sequences are only available during a finite observation window. Because the observation time window is more likely to begin or end during long IETs than during short ones, the analysis of such data is susceptible to a bias induced by the finite observation period. In this paper, we illustrate how this length bias is born and how it can be corrected without assuming any particular shape for the IET distribution. To do this, we model event sequences using stationary renewal processes, and we formulate simple heuristics for determining the severity of the bias. To illustrate our results, we focus on the example of empirical communication networks, which are temporal networks that are constructed from communication events. The IET distributions of such systems guide efforts to build models of human behavior, and the variance of IETs is very important for estimating the spreading rate of information in networks of temporal interactions. We analyze several well-known data sets from the literature, and we find that the resulting bias can lead to systematic underestimates of the variance in the IET distributions and that correcting for the bias can lead to qualitatively different results for the tails of the IET distributions.

Dynamic Correlations between Intrinsic Connectivity and Extrinsic Connectivity of the Auditory Cortex in Humans.

PubMed

Cui, Zhuang; Wang, Qian; Gao, Yayue; Wang, Jing; Wang, Mengyang; Teng, Pengfei; Guan, Yuguang; Zhou, Jian; Li, Tianfu; Luan, Guoming; Li, Liang

2017-01-01

The arrival of sound signals in the auditory cortex (AC) triggers both local and inter-regional signal propagations over time up to hundreds of milliseconds and builds up both intrinsic functional connectivity (iFC) and extrinsic functional connectivity (eFC) of the AC. However, interactions between iFC and eFC are largely unknown. Using intracranial stereo-electroencephalographic recordings in people with drug-refractory epilepsy, this study mainly investigated the temporal dynamic of the relationships between iFC and eFC of the AC. The results showed that a Gaussian wideband-noise burst markedly elicited potentials in both the AC and numerous higher-order cortical regions outside the AC (non-auditory cortices). Granger causality analyses revealed that in the earlier time window, iFC of the AC was positively correlated with both eFC from the AC to the inferior temporal gyrus and that to the inferior parietal lobule. While in later periods, the iFC of the AC was positively correlated with eFC from the precentral gyrus to the AC and that from the insula to the AC. In conclusion, dual-directional interactions occur between iFC and eFC of the AC at different time windows following the sound stimulation and may form the foundation underlying various central auditory processes, including auditory sensory memory, object formation, integrations between sensory, perceptional, attentional, motor, emotional, and executive processes.

Incubation history prior to the canonical thermosensitive period determines sex in the American alligator.

PubMed

McCoy, Jessica A; Parrott, Benjamin B; Rainwater, Thomas R; Wilkinson, Phillip M; Guillette, Louis J

2015-10-01

Despite the widespread occurrence of environmental sex determination (ESD) among vertebrates, our knowledge of the temporal dynamics by which environmental factors act on this process remains limited. In many reptiles, incubation temperature determines sex during a discrete developmental window just prior to and coincident with the differentiation of the gonads. Yet, there is substantial variation in sex ratios among different clutches of eggs incubated at identical temperatures during this period. Here, we test the hypothesis that temperatures experienced prior to the reported thermosensitive period for alligators (Alligator mississippiensis) can impact how the sex determination system responds to thermal cues later in development. Temperature shift experiments on eggs collected from the field within 24  h of oviposition were employed to decouple various maternal influences from thermal effects, and results demonstrate a previously undefined window of thermosensitivity occurring by stage 15 of embryonic development, six stages earlier than previously reported. We also examine the intrasexual expression of several male- and female-biased genes and show that while male-biased genes display no intrasexual differences, ovarian CYP19A1 (aromatase) transcript abundance differs by approximately twofold depending on thermal exposures experienced at early stages of embryonic development. These findings expand our understanding of the ESD in the alligator and provide the rationale for reevaluation of the temporal dynamics of sex determination in other crocodilians. © 2015 Society for Reproduction and Fertility.

Deconvolution improves the accuracy and depth sensitivity of time-resolved measurements

NASA Astrophysics Data System (ADS)

Diop, Mamadou; St. Lawrence, Keith

2013-03-01

Time-resolved (TR) techniques have the potential to distinguish early- from late-arriving photons. Since light travelling through superficial tissue is detected earlier than photons that penetrate the deeper layers, time-windowing can in principle be used to improve the depth sensitivity of TR measurements. However, TR measurements also contain instrument contributions - referred to as the instrument-response-function (IRF) - which cause temporal broadening of the measured temporal-point-spread-function (TPSF). In this report, we investigate the influence of the IRF on pathlength-resolved absorption changes (Δμa) retrieved from TR measurements using the microscopic Beer-Lambert law (MBLL). TPSFs were acquired on homogeneous and two-layer tissue-mimicking phantoms with varying optical properties. The measured IRF and TPSFs were deconvolved to recover the distribution of time-of-flights (DTOFs) of the detected photons. The microscopic Beer-Lambert law was applied to early and late time-windows of the TPSFs and DTOFs to access the effects of the IRF on pathlength-resolved Δμa. The analysis showed that the late part of the TPSFs contains substantial contributions from early-arriving photons, due to the smearing effects of the IRF, which reduced its sensitivity to absorption changes occurring in deep layers. We also demonstrated that the effects of the IRF can be efficiently eliminated by applying a robust deconvolution technique, thereby improving the accuracy and sensitivity of TR measurements to deep-tissue absorption changes.

Variable exhumation rates and variable displacement rates: Documenting recent slowing of Himalayan shortening in western Bhutan

USGS Publications Warehouse

McQuarrie, Nadine; Tobgay, Tobgay; Long, Sean P.; Reiners, Peter W.; Cosca, Michael A.

2014-01-01

We link exhumational variability in space and time to the evolving geometry of the Himalayan fold–thrust belt in western Bhutan. By combining new and published geochronologic and thermochronologic data we document the burial age, peak temperatures and complete cooling history from 20 Ma to the present over an across-strike distance of ∼125 km. These integrated cooling curves highlight windows of fast exhumation that vary spatially and temporally. We propose that pulses of fast exhumation are a result of structures that facilitate the vertical motion of material, illustrated in sequentially-restored cross sections. Due to a range of permissible geometries at depth, we explore and evaluate the impact of geometry on kinematics and rates of deformation. The linked cooling history and cross sections provide estimates of both magnitude and timing of thrust sheet displacement and highlight temporal variability in potential shortening rates. Structural and chronologic data illustrate a general north to south progression of Himalayan deformation, with emplacement of the Main Central thrust (MCT), Paro thrust and Shumar thrust by 12 to no later than 9 Ma. Two different geometries and kinematic scenarios for the Lesser Himalayan duplex are proposed. A north to south propagating duplex system requires that the southern portion of that system, south of the MCT, deformed and cooled by 9 Ma, leaving only the southernmost thrust sheets, including the Main Boundary and Main Frontal thrusts, to deform between 9 and 0 Ma. This limited post 9 Ma shortening would necessitate a marked slowdown in convergence accommodated on the Main Himalayan thrust. A two-tiered duplex system, which allows for the Paro window duplex and the southern Baxa duplex to form simultaneously, permits duplex formation and accompanying exhumation until 6 Ma. Limited cooling from ∼200 °C to the surface post 6 Ma suggests either a decrease in shortening rates from 6 to 0 Ma or that duplex formation and exhumation are temporally decoupled. Our combined cooling curves highlight that the youngest cooling ages may not mark the fastest thrusting rates or the window of fastest exhumation. Instead, temporal variations in exhumation are best viewed through identifying transients in exhumation rate. We suggest that the strongest control on exhumation magnitude and variability is fold–thrust belt geometry, particularly the locations and magnitudes of footwall ramps, which can change over 10ʼs of km distance. Balanced cross sections predict the location and magnitude of these ramps and how they vary in space and time, providing an untapped potential for testing permissible cross-section geometries and kinematics against measured cooling histories.

Evaluation of Aged Garlic Extract Neuroprotective Effect in a Focal Model of Cerebral Ischemia

NASA Astrophysics Data System (ADS)

Aguilera, Penélope; Maldonado, Perla D.; Ortiz-Plata, Alma; Barrera, Diana; Chánez-Cárdenas, María Elena

2008-02-01

The oxidant species generated in cerebral ischemia have been implicated as important mediators of neuronal injury through damage to lipids, DNA, and proteins. Since ischemia as well as reperfusion insults generate oxidative stress, the administration of antioxidants may limit oxidative damage and ameliorate disease progression. The present work shows the transitory neuroprotective effect of the aged garlic extract (AGE) administration (a proposed antioxidant compound) in a middle cerebral artery occlusion (MCAO) model in rats and established its therapeutic window. To determine the optimal time of administration, animal received AGE (1.2 mL/kg) intraperitoneally 30 min before onset of reperfusion (-0.5 R), at the beginning of reperfusion (0R), or 1 h after onset of reperfusion (1R). Additional doses were administrated after 1, 2, or 3 h after onset of reperfusion. To establish the therapeutic window of AGE, the infarct area was determined for each treatment after different times of reperfusion. Results show that the administration of AGE at the onset of reperfusion reduced the infarct area by 70% (evaluated after 2 h reperfusion). The therapeutic window of AGE was determined. Repeated doses did not extend the temporal window of protection. A significant reduction in the nitrotyrosine level was observed in the brain tissue subjected to MCAO after AGE treatment at the onset of reperfusion. Data in the present work show that AGE exerts a transitory neuroprotective effect in response to ischemia/reperfusion-induced neuronal injury.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ojeda-Gonzalez, A.; Prestes, A.; Klausner, V.

Spatio-temporal entropy (STE) analysis is used as an alternative mathematical tool to identify possible magnetic cloud (MC) candidates. We analyze Interplanetary Magnetic Field (IMF) data using a time interval of only 10 days. We select a convenient data interval of 2500 records moving forward by 200 record steps until the end of the time series. For every data segment, the STE is calculated at each step. During an MC event, the STE reaches values close to zero. This extremely low value of STE is due to MC structure features. However, not all of the magnetic components in MCs have STEmore » values close to zero at the same time. For this reason, we create a standardization index (the so-called Interplanetary Entropy, IE, index). This index is a worthwhile effort to develop new tools to help diagnose ICME structures. The IE was calculated using a time window of one year (1999), and it has a success rate of 70% over other identifiers of MCs. The unsuccessful cases (30%) are caused by small and weak MCs. The results show that the IE methodology identified 9 of 13 MCs, and emitted nine false alarm cases. In 1999, a total of 788 windows of 2500 values existed, meaning that the percentage of false alarms was 1.14%, which can be considered a good result. In addition, four time windows, each of 10 days, are studied, where the IE method was effective in finding MC candidates. As a novel result, two new MCs are identified in these time windows.« less

Seeing Emotion with Your Ears: Emotional Prosody Implicitly Guides Visual Attention to Faces

PubMed Central

Rigoulot, Simon; Pell, Marc D.

2012-01-01

Interpersonal communication involves the processing of multimodal emotional cues, particularly facial expressions (visual modality) and emotional speech prosody (auditory modality) which can interact during information processing. Here, we investigated whether the implicit processing of emotional prosody systematically influences gaze behavior to facial expressions of emotion. We analyzed the eye movements of 31 participants as they scanned a visual array of four emotional faces portraying fear, anger, happiness, and neutrality, while listening to an emotionally-inflected pseudo-utterance (Someone migged the pazing) uttered in a congruent or incongruent tone. Participants heard the emotional utterance during the first 1250 milliseconds of a five-second visual array and then performed an immediate recall decision about the face they had just seen. The frequency and duration of first saccades and of total looks in three temporal windows ([0–1250 ms], [1250–2500 ms], [2500–5000 ms]) were analyzed according to the emotional content of faces and voices. Results showed that participants looked longer and more frequently at faces that matched the prosody in all three time windows (emotion congruency effect), although this effect was often emotion-specific (with greatest effects for fear). Effects of prosody on visual attention to faces persisted over time and could be detected long after the auditory information was no longer present. These data imply that emotional prosody is processed automatically during communication and that these cues play a critical role in how humans respond to related visual cues in the environment, such as facial expressions. PMID:22303454

Memory Reactivation Enables Long-Term Prevention of Interference.

PubMed

Herszage, Jasmine; Censor, Nitzan

2017-05-22

The ability of the human brain to successively learn or perform two competing tasks constitutes a major challenge in daily function. Indeed, exposing the brain to two different competing memories within a short temporal offset can induce interference, resulting in deteriorated performance in at least one of the learned memories [1-4]. Although previous studies have investigated online interference and its effects on performance [5-13], whether the human brain can enable long-term prevention of future interference is unknown. To address this question, we utilized the memory reactivation-reconsolidation framework [2, 12] stemming from studies at the synaptic level [14-17], according to which reactivation of a memory enables its update. In a set of experiments, using the motor sequence learning task [18] we report that a unique pairing of reactivating the original memory (right hand) in synchrony with novel memory trials (left hand) prevented future interference between the two memories. Strikingly, these effects were long-term and observed a month following reactivation. Further experiments showed that preventing future interference was not due to practice per se, but rather specifically depended on a limited time window induced by reactivation of the original memory. These results suggest a mechanism according to which memory reactivation enables long-term prevention of interference, possibly by creating an updated memory trace integrating original and novel memories during the reconsolidation time window. The opportunity to induce a long-term preventive effect on memories may enable the utilization of strategies optimizing normal human learning, as well as recovery following neurological insults. Copyright © 2017 Elsevier Ltd. All rights reserved.

Uncertainty visualisation in the Model Web

NASA Astrophysics Data System (ADS)

Gerharz, L. E.; Autermann, C.; Hopmann, H.; Stasch, C.; Pebesma, E.

2012-04-01

Visualisation of geospatial data as maps is a common way to communicate spatially distributed information. If temporal and furthermore uncertainty information are included in the data, efficient visualisation methods are required. For uncertain spatial and spatio-temporal data, numerous visualisation methods have been developed and proposed, but only few tools for visualisation of data in a standardised way exist. Furthermore, usually they are realised as thick clients, and lack functionality of handling data coming from web services as it is envisaged in the Model Web. We present an interactive web tool for visualisation of uncertain spatio-temporal data developed in the UncertWeb project. The client is based on the OpenLayers JavaScript library. OpenLayers provides standard map windows and navigation tools, i.e. pan, zoom in/out, to allow interactive control for the user. Further interactive methods are implemented using jStat, a JavaScript library for statistics plots developed in UncertWeb, and flot. To integrate the uncertainty information into existing standards for geospatial data, the Uncertainty Markup Language (UncertML) was applied in combination with OGC Observations&Measurements 2.0 and JavaScript Object Notation (JSON) encodings for vector and NetCDF for raster data. The client offers methods to visualise uncertain vector and raster data with temporal information. Uncertainty information considered for the tool are probabilistic and quantified attribute uncertainties which can be provided as realisations or samples, full probability distributions functions and statistics. Visualisation is supported for uncertain continuous and categorical data. In the client, the visualisation is realised using a combination of different methods. Based on previously conducted usability studies, a differentiation between expert (in statistics or mapping) and non-expert users has been indicated as useful. Therefore, two different modes are realised together in the tool: (i) adjacent maps showing data and uncertainty separately, and (ii) multidimensional mapping providing different visualisation methods in combination to explore the spatial, temporal and uncertainty distribution of the data. Adjacent maps allow a simpler visualisation by separating value and uncertainty maps for non-experts and a first overview. The multidimensional approach allows a more complex exploration of the data for experts by browsing through the different dimensions. It offers the visualisation of maps, statistic plots and time series in different windows and sliders to interactively move through time, space and uncertainty (thresholds).

Occupational Home Economics Education Series. Window Treatment Services. Competency Based Teaching Module.

ERIC Educational Resources Information Center

Lowe, Phyllis; And Others

This module, one of ten competency based modules developed for vocational home economics teachers, is based on a job cluster in window treatment services. It can be used for various types of learners such as the handicapped, slowlearners, high school students, and adults including senior citizens. Focusing on the specific job title of window…

Using genetic algorithms to optimize the analogue method for precipitation prediction in the Swiss Alps

NASA Astrophysics Data System (ADS)

Horton, Pascal; Jaboyedoff, Michel; Obled, Charles

2018-01-01

Analogue methods provide a statistical precipitation prediction based on synoptic predictors supplied by general circulation models or numerical weather prediction models. The method samples a selection of days in the archives that are similar to the target day to be predicted, and consider their set of corresponding observed precipitation (the predictand) as the conditional distribution for the target day. The relationship between the predictors and predictands relies on some parameters that characterize how and where the similarity between two atmospheric situations is defined. This relationship is usually established by a semi-automatic sequential procedure that has strong limitations: (i) it cannot automatically choose the pressure levels and temporal windows (hour of the day) for a given meteorological variable, (ii) it cannot handle dependencies between parameters, and (iii) it cannot easily handle new degrees of freedom. In this work, a global optimization approach relying on genetic algorithms could optimize all parameters jointly and automatically. The global optimization was applied to some variants of the analogue method for the Rhône catchment in the Swiss Alps. The performance scores increased compared to reference methods, especially for days with high precipitation totals. The resulting parameters were found to be relevant and coherent between the different subregions of the catchment. Moreover, they were obtained automatically and objectively, which reduces the effort that needs to be invested in exploration attempts when adapting the method to a new region or for a new predictand. For example, it obviates the need to assess a large number of combinations of pressure levels and temporal windows of predictor variables that were manually selected beforehand. The optimization could also take into account parameter inter-dependencies. In addition, the approach allowed for new degrees of freedom, such as a possible weighting between pressure levels, and non-overlapping spatial windows.

Emergence and temporal structure of Lead-Lag correlations in collective stock dynamics

NASA Astrophysics Data System (ADS)

Xia, Lisi; You, Daming; Jiang, Xin; Chen, Wei

2018-07-01

Understanding the correlations among stock returns is crucial for reducing the risk of investment in stock markets. As an important stylized correlation, lead-lag effect plays a major role in analyzing market volatility and deriving trading strategies. Here, we explore historical lead-lag relationships among stocks in the Chinese stock market. Strongly positive lagged correlations can be empirically observed. We demonstrate this lead-lag phenomenon is not constant but temporally emerges during certain periods. By introducing moving time window method, we transform the lead-lag dynamics into a series of asymmetric lagged correlation matrices. Dynamic lead-lag structures are uncovered in the form of temporal network structures. We find that the size of lead-lag group experienced a rapid drop during the year 2012, which signaled a re-balance of the stock market. On the daily timescale, we find the lead-lag structure exhibits several persistent patterns, which can be characterized by the Jaccard matrix. We show significant market events can be distinguished in the Jaccard matrix diagram. Taken together, we study an integration of all the temporal networks and identify several leading stock sectors, which are in accordance with the common Chinese economic fundamentals.

Temporally-aware algorithms for the classification of anuran sounds.

PubMed

Luque, Amalia; Romero-Lemos, Javier; Carrasco, Alejandro; Gonzalez-Abril, Luis

2018-01-01

Several authors have shown that the sounds of anurans can be used as an indicator of climate change. Hence, the recording, storage and further processing of a huge number of anuran sounds, distributed over time and space, are required in order to obtain this indicator. Furthermore, it is desirable to have algorithms and tools for the automatic classification of the different classes of sounds. In this paper, six classification methods are proposed, all based on the data-mining domain, which strive to take advantage of the temporal character of the sounds. The definition and comparison of these classification methods is undertaken using several approaches. The main conclusions of this paper are that: (i) the sliding window method attained the best results in the experiments presented, and even outperformed the hidden Markov models usually employed in similar applications; (ii) noteworthy overall classification performance has been obtained, which is an especially striking result considering that the sounds analysed were affected by a highly noisy background; (iii) the instance selection for the determination of the sounds in the training dataset offers better results than cross-validation techniques; and (iv) the temporally-aware classifiers have revealed that they can obtain better performance than their non-temporally-aware counterparts.

Temporally-aware algorithms for the classification of anuran sounds

PubMed Central

Gonzalez-Abril, Luis

2018-01-01

Several authors have shown that the sounds of anurans can be used as an indicator of climate change. Hence, the recording, storage and further processing of a huge number of anuran sounds, distributed over time and space, are required in order to obtain this indicator. Furthermore, it is desirable to have algorithms and tools for the automatic classification of the different classes of sounds. In this paper, six classification methods are proposed, all based on the data-mining domain, which strive to take advantage of the temporal character of the sounds. The definition and comparison of these classification methods is undertaken using several approaches. The main conclusions of this paper are that: (i) the sliding window method attained the best results in the experiments presented, and even outperformed the hidden Markov models usually employed in similar applications; (ii) noteworthy overall classification performance has been obtained, which is an especially striking result considering that the sounds analysed were affected by a highly noisy background; (iii) the instance selection for the determination of the sounds in the training dataset offers better results than cross-validation techniques; and (iv) the temporally-aware classifiers have revealed that they can obtain better performance than their non-temporally-aware counterparts. PMID:29740517

The effect of image alignment on capillary blood flow measurement of the neuroretinal rim using the Heidelberg retina flowmeter

PubMed Central

Sehi, M; Flanagan, J G

2004-01-01

Aim: To examine the influence of image alignment on the repeatability of blood flow measurements of the optic nerve. Methods: 10 normal subjects were examined. Heidelberg retina tomograph imaging was performed to establish best location and focus for the temporal neuroretinal rim. Two high quality Heidelberg retina flowmeter (HRF) images were acquired for three methods of alignment: central, nasal, and temporal. A 10×10 pixel measurement window was selected and exactly reproduced on all images. The interquartile pixel values were used to calculate capillary flow. ANOVA, intraclass correlation coefficients (ICC) and the coefficient of repeatability (CoR) were used for analysis. Results: There was no difference between methods (p = 0.47) or between visits (p = 0.51). The ICCs were 0.83 for the central, 0.34 for the nasal, and 0.42 for the temporal alignment. The CoR was 31.5 for central (mean effect 235.1), 234.6 for nasal, and 256.7 for temporal alignment. Conclusion: Central alignment was the most repeatable method for the measurement of neuroretinal rim capillary blood flow using the HRF. PMID:14736775

Attenuating fearful memories: effect of cued extinction on intrusions.

PubMed

Marks, Elizabeth H; Zoellner, Lori A

2014-12-01

Exposure-based therapies for posttraumatic stress disorder are thought to reduce intrusive memories through extinction processes. Methods that enhance extinction may translate to improved treatment. Rat research suggests retrieving a memory via a conditioned stimulus (CS) cue, and then modifying the retrieved memory within a specific reconsolidation window may enhance extinction. In humans, studies (e.g., Kindt & Soeter, 2013; Schiller et al., 2010) using basic learning paradigms show discrepant findings. Using a distressing film paradigm, participants (N = 148) completed fear acquisition and extinction. At extinction, they were randomized to 1 of 3 groups: CS cue within reconsolidation window, CS cue outside window, or non-CS cue within window. Intrusions were assessed 24 hr after extinction. Participants receiving the CS cue and completing extinction within the reconsolidation window had more intrusions (M = 2.40, SD = 2.54) than those cued outside (M = 1.65, SD = 1.70) or those receiving a non-CS cue (M = 1.24, SD = 1.26), F(2, 145) = 4.52, p = .01, d = 0.55. Consistent with the reconsolidation hypothesis, presenting a CS cue does appear to activate a specific period of time during which a memory can be updated. However, the CS cue caused increased, rather than decreased, frequency of intrusions. Understanding parameters of preextinction cueing may help us better understand reconsolidation as a potential memory updating mechanism.

Software for illustrative presentation of basic clinical characteristics of laboratory tests--GraphROC for Windows.

PubMed

Kairisto, V; Poola, A

1995-01-01

GraphROC for Windows is a program for clinical test evaluation. It was designed for the handling of large datasets obtained from clinical laboratory databases. In the user interface, graphical and numerical presentations are combined. For simplicity, numerical data is not shown unless requested. Relevant numbers can be "picked up" from the graph by simple mouse operations. Reference distributions can be displayed by using automatically optimized bin widths. Any percentile of the distribution with corresponding confidence limits can be chosen for display. In sensitivity-specificity analysis, both illness- and health-related distributions are shown in the same graph. The following data for any cutoff limit can be shown in a separate click window: clinical sensitivity and specificity with corresponding confidence limits, positive and negative likelihood ratios, positive and negative predictive values and efficiency. Predictive values and clinical efficiency of the cutoff limit can be updated for any prior probability of disease. Receiver Operating Characteristics (ROC) curves can be generated and combined into the same graph for comparison of several different tests. The area under the curve with corresponding confidence interval is calculated for each ROC curve. Numerical results of analyses and graphs can be printed or exported to other Microsoft Windows programs. GraphROC for Windows also employs a new method, developed by us, for the indirect estimation of health-related limits and change limits from mixed distributions of clinical laboratory data.

Categorization for Faces and Tools—Two Classes of Objects Shaped by Different Experience—Differs in Processing Timing, Brain Areas Involved, and Repetition Effects

PubMed Central

Kozunov, Vladimir; Nikolaeva, Anastasia; Stroganova, Tatiana A.

2018-01-01

The brain mechanisms that integrate the separate features of sensory input into a meaningful percept depend upon the prior experience of interaction with the object and differ between categories of objects. Recent studies using representational similarity analysis (RSA) have characterized either the spatial patterns of brain activity for different categories of objects or described how category structure in neuronal representations emerges in time, but never simultaneously. Here we applied a novel, region-based, multivariate pattern classification approach in combination with RSA to magnetoencephalography data to extract activity associated with qualitatively distinct processing stages of visual perception. We asked participants to name what they see whilst viewing bitonal visual stimuli of two categories predominantly shaped by either value-dependent or sensorimotor experience, namely faces and tools, and meaningless images. We aimed to disambiguate the spatiotemporal patterns of brain activity between the meaningful categories and determine which differences in their processing were attributable to either perceptual categorization per se, or later-stage mentalizing-related processes. We have extracted three stages of cortical activity corresponding to low-level processing, category-specific feature binding, and supra-categorical processing. All face-specific spatiotemporal patterns were associated with bilateral activation of ventral occipito-temporal areas during the feature binding stage at 140–170 ms. The tool-specific activity was found both within the categorization stage and in a later period not thought to be associated with binding processes. The tool-specific binding-related activity was detected within a 210–220 ms window and was located to the intraparietal sulcus of the left hemisphere. Brain activity common for both meaningful categories started at 250 ms and included widely distributed assemblies within parietal, temporal, and prefrontal regions. Furthermore, we hypothesized and tested whether activity within face and tool-specific binding-related patterns would demonstrate oppositely acting effects following procedural perceptual learning. We found that activity in the ventral, face-specific network increased following the stimuli repetition. In contrast, tool processing in the dorsal network adapted by reducing its activity over the repetition period. Altogether, we have demonstrated that activity associated with visual processing of faces and tools during the categorization stage differ in processing timing, brain areas involved, and in their dynamics underlying stimuli learning. PMID:29379426

Categorization for Faces and Tools-Two Classes of Objects Shaped by Different Experience-Differs in Processing Timing, Brain Areas Involved, and Repetition Effects.

PubMed

Kozunov, Vladimir; Nikolaeva, Anastasia; Stroganova, Tatiana A

2017-01-01

The brain mechanisms that integrate the separate features of sensory input into a meaningful percept depend upon the prior experience of interaction with the object and differ between categories of objects. Recent studies using representational similarity analysis (RSA) have characterized either the spatial patterns of brain activity for different categories of objects or described how category structure in neuronal representations emerges in time, but never simultaneously. Here we applied a novel, region-based, multivariate pattern classification approach in combination with RSA to magnetoencephalography data to extract activity associated with qualitatively distinct processing stages of visual perception. We asked participants to name what they see whilst viewing bitonal visual stimuli of two categories predominantly shaped by either value-dependent or sensorimotor experience, namely faces and tools, and meaningless images. We aimed to disambiguate the spatiotemporal patterns of brain activity between the meaningful categories and determine which differences in their processing were attributable to either perceptual categorization per se , or later-stage mentalizing-related processes. We have extracted three stages of cortical activity corresponding to low-level processing, category-specific feature binding, and supra-categorical processing. All face-specific spatiotemporal patterns were associated with bilateral activation of ventral occipito-temporal areas during the feature binding stage at 140-170 ms. The tool-specific activity was found both within the categorization stage and in a later period not thought to be associated with binding processes. The tool-specific binding-related activity was detected within a 210-220 ms window and was located to the intraparietal sulcus of the left hemisphere. Brain activity common for both meaningful categories started at 250 ms and included widely distributed assemblies within parietal, temporal, and prefrontal regions. Furthermore, we hypothesized and tested whether activity within face and tool-specific binding-related patterns would demonstrate oppositely acting effects following procedural perceptual learning. We found that activity in the ventral, face-specific network increased following the stimuli repetition. In contrast, tool processing in the dorsal network adapted by reducing its activity over the repetition period. Altogether, we have demonstrated that activity associated with visual processing of faces and tools during the categorization stage differ in processing timing, brain areas involved, and in their dynamics underlying stimuli learning.

Acoustic Observation of the Time Dependence of the Roughness of Sandy Seafloors

DTIC Science & Technology

2009-11-25

relations between acoustic and roughness temporal correlations are developed and applied. Manuscript received April 23, 2007; revised June 04. 2008 and...Fourier transform of the relief function as follows: (F(K2, t2)F*(Klt h)) = W(KU tu t2)6{Ki - K2) . (6) The presence of the Dirac delta function is only...appropriate if /(R, t) is stationary with infinite extent in the spatial coordi- nates. As a result of the windowing assumed here, the delta func

Pulmonary artery imaging under free-breathing using golden-angle radial bSSFP MRI: a proof of concept.

PubMed

Fyrdahl, Alexander; Vargas Paris, Roberto; Nyrén, Sven; Holst, Karen; Ugander, Martin; Lindholm, Peter; Sigfridsson, Andreas

2018-03-14

To evaluate the feasibility of an improved motion and flow robust methodology for imaging the pulmonary vasculature using non-contrast-enhanced, free-breathing, golden-angle radial MRI. Healthy volunteers (n = 10, age 46 ± 11 years, 50% female) and patients (n = 2, ages 27 and 84, both female) were imaged at 1.5 T using a Cartesian and golden-angle radial 2D balanced SSFP pulse sequence. The acquisitions were made under free breathing without contrast agent enhancement. The radial acquisitions were reconstructed at 3 temporal footprints. All series were scored from 1 to 5 for perceived diagnostic quality, artifact level, and vessel sharpness in multiple anatomical locations. In addition, vessel sharpness and blood-to-blood clot contrast were measured. Quantitative measurements showed higher vessel sharpness for golden-angle radial (n = 76, 0.79 ± 0.11 versus 0.71 ± 0.16, p < .05). Blood-to-blood clot contrast was found to be 23% higher in golden-angle radial in the 2 patients. At comparable temporal footprints, golden-angle radial was scored higher for diagnostic quality (mean ± SD, 2.3 ± 0.7 versus 2.2 ± 0.6, p < .01) and vessel sharpness (2.2 ± 0.8 versus 2.1 ± 0.5, p < .01), whereas the artifact level did not differ (3.0 ± 0.9 versus 3.0 ± 1.0, p = .80). The ability to retrospectively choose a temporal resolution and perform sliding-window reconstructions was demonstrated in patients. In pulmonary artery imaging, the motion and flow robustness of a radial trajectory does both improve image quality over Cartesian trajectory in healthy volunteers, and allows for flexible selection of temporal footprints and the ability to perform real-time sliding window reconstructions, which could potentially provide further diagnostic insight. © 2018 International Society for Magnetic Resonance in Medicine.

Streak camera based SLR receiver for two color atmospheric measurements

NASA Technical Reports Server (NTRS)

Varghese, Thomas K.; Clarke, Christopher; Oldham, Thomas; Selden, Michael

1993-01-01

To realize accurate two-color differential measurements, an image digitizing system with variable spatial resolution was designed, built, and integrated to a photon-counting picosecond streak camera, yielding a temporal scan resolution better than 300 femtosecond/pixel. The streak camera is configured to operate with 3 spatial channels; two of these support green (532 nm) and uv (355 nm) while the third accommodates reference pulses (764 nm) for real-time calibration. Critical parameters affecting differential timing accuracy such as pulse width and shape, number of received photons, streak camera/imaging system nonlinearities, dynamic range, and noise characteristics were investigated to optimize the system for accurate differential delay measurements. The streak camera output image consists of three image fields, each field is 1024 pixels along the time axis and 16 pixels across the spatial axis. Each of the image fields may be independently positioned across the spatial axis. Two of the image fields are used for the two wavelengths used in the experiment; the third window measures the temporal separation of a pair of diode laser pulses which verify the streak camera sweep speed for each data frame. The sum of the 16 pixel intensities across each of the 1024 temporal positions for the three data windows is used to extract the three waveforms. The waveform data is processed using an iterative three-point running average filter (10 to 30 iterations are used) to remove high-frequency structure. The pulse pair separations are determined using the half-max and centroid type analysis. Rigorous experimental verification has demonstrated that this simplified process provides the best measurement accuracy. To calibrate the receiver system sweep, two laser pulses with precisely known temporal separation are scanned along the full length of the sweep axis. The experimental measurements are then modeled using polynomial regression to obtain a best fit to the data. Data aggregation using normal point approach has provided accurate data fitting techniques and is found to be much more convenient than using the full rate single shot data. The systematic errors from this model have been found to be less than 3 ps for normal points.

Error analysis and new dual-cosine window for estimating the sensor frequency response function from the step response data

NASA Astrophysics Data System (ADS)

Yang, Shuang-Long; Liang, Li-Ping; Liu, Hou-De; Xu, Ke-Jun

2018-03-01

Aiming at reducing the estimation error of the sensor frequency response function (FRF) estimated by the commonly used window-based spectral estimation method, the error models of interpolation and transient errors are derived in the form of non-parameter models. Accordingly, window effects on the errors are analyzed and reveal that the commonly used hanning window leads to smaller interpolation error which can also be significantly eliminated by the cubic spline interpolation method when estimating the FRF from the step response data, and window with smaller front-end value can restrain more transient error. Thus, a new dual-cosine window with its non-zero discrete Fourier transform bins at -3, -1, 0, 1, and 3 is constructed for FRF estimation. Compared with the hanning window, the new dual-cosine window has the equivalent interpolation error suppression capability and better transient error suppression capability when estimating the FRF from the step response; specifically, it reduces the asymptotic property of the transient error from O(N-2) of the hanning window method to O(N-4) while only increases the uncertainty slightly (about 0.4 dB). Then, one direction of a wind tunnel strain gauge balance which is a high order, small damping, and non-minimum phase system is employed as the example for verifying the new dual-cosine window-based spectral estimation method. The model simulation result shows that the new dual-cosine window method is better than the hanning window method for FRF estimation, and compared with the Gans method and LPM method, it has the advantages of simple computation, less time consumption, and short data requirement; the actual data calculation result of the balance FRF is consistent to the simulation result. Thus, the new dual-cosine window is effective and practical for FRF estimation.

Low-E Storm Windows Gain Acceptance as a Home Weatherization Measure

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gilbride, Theresa L.; Cort, Katherine A.

This article for Home Energy Magazine describes work by the U.S. Department of Energy to develop low-emissivity storm windows as an energy efficiency-retrofit option for existing homes. The article describes the low-emissivity invisible silver metal coatings on the glass, which reflect heat back into the home in winter or back outside in summer and the benefits of low-e storm windows including insulation, air sealing, noise blocking, protection of antique windows, etc. The article also describes Pacific Northwest National Laboratory's efforts on behalf of DOE to overcome market barriers to adoption of the technology, including performance validation studies in the PNNLmore » Lab Homes, cost effectiveness analysis, production of reports, brochures, how-to guides on low-e storm window installation for the Building America Solution Center, and a video posted on YouTube. PNNL's efforts were reviewed by the Pacific Northwest Regional Technical Forum (RTF), which serves as the advisory board to the Pacific Northwest Electric Power Planning Council and Bonneville Power Administration. In late July 2015, the RTF approved the low-e storm window measure’s savings and specifications, a critical step in integrating low-e storm windows into energy-efficiency planning and utility weatherization and incentive programs. PNNL estimates that more than 90 million homes in the United States with single-pane or low-performing double-pane windows would benefit from the technology. Low-e storm windows are suitable not only for private residences but also for small commercial buildings, historic properties, and facilities that house residents, such as nursing homes, dormitories, and in-patient facilities. To further assist in the market transformation of low-e storm windows and other high-efficiency window attachments, DOE helped found the window Attachment Energy Rating Council (AERC) in 2015. AERC is an independent, public interest, non-profit organization whose mission is to rate, label, and certify the performance of window attachments.« less

Early and late components of EEG delay activity correlate differently with scene working memory performance

PubMed Central

Ng, Kenneth; Reichert, Chelsea P.

2017-01-01

Sustained and elevated activity during the working memory delay period has long been considered the primary neural correlate for maintaining information over short time intervals. This idea has recently been reinterpreted in light of findings generated from multiple neural recording modalities and levels of analysis. To further investigate the sustained or transient nature of activity, the temporal-spectral evolution (TSE) of delay period activity was examined in humans with high density EEG during performance of a Sternberg working memory paradigm with a relatively long six second delay and with novel scenes as stimuli. Multiple analyses were conducted using different trial window durations and different baseline periods for TSE computation. Sensor level analyses revealed transient rather than sustained activity during delay periods. Specifically, the consistent finding among the analyses was that high amplitude activity encompassing the theta range was found early in the first three seconds of the delay period. These increases in activity early in the delay period correlated positively with subsequent ability to distinguish new from old probe scenes. Source level signal estimation implicated a right parietal region of transient early delay activity that correlated positively with working memory ability. This pattern of results adds to recent evidence that transient rather than sustained delay period activity supports visual working memory performance. The findings are discussed in relation to synchronous and desynchronous intra- and inter-regional neural transmission, and choosing an optimal baseline for expressing temporal-spectral delay activity change. PMID:29016657

Assessing the effect of physical differences in the articulation of consonants and vowels on audiovisual temporal perception

PubMed Central

Vatakis, Argiro; Maragos, Petros; Rodomagoulakis, Isidoros; Spence, Charles

2012-01-01

We investigated how the physical differences associated with the articulation of speech affect the temporal aspects of audiovisual speech perception. Video clips of consonants and vowels uttered by three different speakers were presented. The video clips were analyzed using an auditory-visual signal saliency model in order to compare signal saliency and behavioral data. Participants made temporal order judgments (TOJs) regarding which speech-stream (auditory or visual) had been presented first. The sensitivity of participants' TOJs and the point of subjective simultaneity (PSS) were analyzed as a function of the place, manner of articulation, and voicing for consonants, and the height/backness of the tongue and lip-roundedness for vowels. We expected that in the case of the place of articulation and roundedness, where the visual-speech signal is more salient, temporal perception of speech would be modulated by the visual-speech signal. No such effect was expected for the manner of articulation or height. The results demonstrate that for place and manner of articulation, participants' temporal percept was affected (although not always significantly) by highly-salient speech-signals with the visual-signals requiring smaller visual-leads at the PSS. This was not the case when height was evaluated. These findings suggest that in the case of audiovisual speech perception, a highly salient visual-speech signal may lead to higher probabilities regarding the identity of the auditory-signal that modulate the temporal window of multisensory integration of the speech-stimulus. PMID:23060756

TEMPORAL SELF-ORGANIZATION IN GALAXY FORMATION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cen, Renyue, E-mail: cen@astro.princeton.edu

We report on the discovery of a relation between the number of star formation (SF) peaks per unit time, ν{sub peak}, and the size of the temporal smoothing window function, Δt, used to define the peaks: ν{sub peak}∝Δt {sup 1} {sup –} {sup φ} (φ ∼ 1.618). This relation holds over the range of Δt = 10-1000 Myr that can be reliably computed here, using a large sample of galaxies obtained from a state-of-the-art cosmological hydrodynamic simulation. This means that the temporal distribution of SF peaks in galaxies as a population is fractal with a Hausdorff fractal dimension equal to φmore » – 1. This finding reveals, for the first time, that the superficially chaotic process of galaxy formation is underlined by temporal self-organization up to at least one gigayear. It is tempting to suggest that, given the known existence of spatial fractals (such as the power-law two-point function of galaxies), there is a joint spatio-temporal self-organization in galaxy formation. From an observational perspective, it will be urgent to devise diagnostics to probe the SF histories of galaxies with good temporal resolution to facilitate a test of this prediction. If confirmed, it would provide unambiguous evidence for a new picture of galaxy formation that is interaction driven, cooperative, and coherent in and between time and space. Unravelling its origin may hold the key to understanding galaxy formation.« less

Derivation and evaluation of land surface temperature from the geostationary operational environmental satellite series

NASA Astrophysics Data System (ADS)

Fang, Li

The Geostationary Operational Environmental Satellites (GOES) have been continuously monitoring the earth surface since 1970, providing valuable and intensive data from a very broad range of wavelengths, day and night. The National Oceanic and Atmospheric Administration's (NOAA's) National Environmental Satellite, Data, and Information Service (NESDIS) is currently operating GOES-15 and GOES-13. The design of the GOES series is now heading to the 4 th generation. GOES-R, as a representative of the new generation of the GOES series, is scheduled to be launched in 2015 with higher spatial and temporal resolution images and full-time soundings. These frequent observations provided by GOES Image make them attractive for deriving information on the diurnal land surface temperature (LST) cycle and diurnal temperature range (DTR). These parameters are of great value for research on the Earth's diurnal variability and climate change. Accurate derivation of satellite-based LSTs from thermal infrared data has long been an interesting and challenging research area. To better support the research on climate change, the generation of consistent GOES LST products for both GOES-East and GOES-West from operational dataset as well as historical archive is in great demand. The derivation of GOES LST products and the evaluation of proposed retrieval methods are two major objectives of this study. Literature relevant to satellite-based LST retrieval techniques was reviewed. Specifically, the evolution of two LST algorithm families and LST retrieval methods for geostationary satellites were summarized in this dissertation. Literature relevant to the evaluation of satellite-based LSTs was also reviewed. All the existing methods are a valuable reference to develop the GOES LST product. The primary objective of this dissertation is the development of models for deriving consistent GOES LSTs with high spatial and high temporal coverage. Proper LST retrieval algorithms were studied according to the characteristics of the imager onboard the GOES series. For the GOES 8-11 and GOES R series with split window (SW) channels, a new temperature and emissivity separation (TES) approach was proposed for deriving LST and LSE simultaneously by using multiple-temporal satellite observations. Two split-window regression formulas were selected for this approach, and two satellite observations over the same geo-location within a certain time interval were utilized. This method is particularly applicable to geostationary satellite missions from which qualified multiple-temporal observations are available. For the GOES M(12)-Q series without SW channels, the dual-window LST algorithm was adopted to derive LST. Instead of using the conventional training method to generate coefficients for the LST regression algorithms, a machine training technique was introduced to automatically select the criteria and the boundary of the sub-ranges for generating algorithm coefficients under different conditions. A software package was developed to produce a brand new GOES LST product from both operational GOES measurements and historical archive. The system layers of the software and related system input and output were illustrated in this work. Comprehensive evaluation of GOES LST products was conducted by validating products against multiple ground-based LST observations, LST products from fine-resolution satellites (e.g. MODIS) and GSIP LST products. The key issues relevant to the cloud diffraction effect were studied as well. GOES measurements as well as ancillary data, including satellite and solar geometry, water vapor, cloud mask, land emissivity etc., were collected to generate GOES LST products. In addition, multiple in situ temperature measurements were collected to test the performance of the proposed GOES LST retrieval algorithms. The ground-based dataset included direct surface temperature measurements from the Atmospheric Radiation Measurement program (ARM), and indirect measurements (surface long-wave radiation observations) from the SURFace RADiation Budget (SURFRAD) Network. A simulated dataset was created to analyse the sensitivity of the proposed retrieval algorithms. In addition, the MODIS LST and GSIP LST products were adopted to cross-evaluate the accuracy of the GOES LST products. Evaluation results demonstrate that the proposed GOES LST system is capable of deriving consistent land surface temperatures with good retrieval precision. Consistent GOES LST products with high spatial/temporal coverage and reliable accuracy will better support detections and observations of meteorological over land surfaces.

Simplified Computation for Nonparametric Windows Method of Probability Density Function Estimation.

PubMed

Joshi, Niranjan; Kadir, Timor; Brady, Michael

2011-08-01

Recently, Kadir and Brady proposed a method for estimating probability density functions (PDFs) for digital signals which they call the Nonparametric (NP) Windows method. The method involves constructing a continuous space representation of the discrete space and sampled signal by using a suitable interpolation method. NP Windows requires only a small number of observed signal samples to estimate the PDF and is completely data driven. In this short paper, we first develop analytical formulae to obtain the NP Windows PDF estimates for 1D, 2D, and 3D signals, for different interpolation methods. We then show that the original procedure to calculate the PDF estimate can be significantly simplified and made computationally more efficient by a judicious choice of the frame of reference. We have also outlined specific algorithmic details of the procedures enabling quick implementation. Our reformulation of the original concept has directly demonstrated a close link between the NP Windows method and the Kernel Density Estimator.

Tuneable complementary metamaterial structures based on graphene for single and multiple transparency windows

PubMed Central

Ding, Jun; Arigong, Bayaner; Ren, Han; Zhou, Mi; Shao, Jin; Lu, Meng; Chai, Yang; Lin, Yuankun; Zhang, Hualiang

2014-01-01

Novel graphene-based tunable plasmonic metamaterials featuring single and multiple transparency windows are numerically studied in this paper. The designed structures consist of a graphene layer perforated with quadrupole slot structures and dolmen-like slot structures printed on a substrate. Specifically, the graphene-based quadrupole slot structure can realize a single transparency window, which is achieved without breaking the structure symmetry. Further investigations have shown that the single transparency window in the proposed quadrupole slot structure is more likely originated from the quantum effect of Autler-Townes splitting. Then, by introducing a dipole slot to the quadrupole slot structure to form the dolmen-like slot structure, an additional transmission dip could occur in the transmission spectrum, thus, a multiple-transparency-window system can be achieved (for the first time for graphene-based devices). More importantly, the transparency windows for both the quadrupole slot and the dolmen-like slot structures can be dynamically controlled over a broad frequency range by varying the Fermi energy levels of the graphene layer (through electrostatic gating). The proposed slot metamaterial structures with tunable single and multiple transparency windows could find potential applications in many areas such as multiple-wavelength slow-light devices, active plasmonic switching, and optical sensing. PMID:25146672

Tuneable complementary metamaterial structures based on graphene for single and multiple transparency windows.

PubMed

Ding, Jun; Arigong, Bayaner; Ren, Han; Zhou, Mi; Shao, Jin; Lu, Meng; Chai, Yang; Lin, Yuankun; Zhang, Hualiang

2014-08-22

Novel graphene-based tunable plasmonic metamaterials featuring single and multiple transparency windows are numerically studied in this paper. The designed structures consist of a graphene layer perforated with quadrupole slot structures and dolmen-like slot structures printed on a substrate. Specifically, the graphene-based quadrupole slot structure can realize a single transparency window, which is achieved without breaking the structure symmetry. Further investigations have shown that the single transparency window in the proposed quadrupole slot structure is more likely originated from the quantum effect of Autler-Townes splitting. Then, by introducing a dipole slot to the quadrupole slot structure to form the dolmen-like slot structure, an additional transmission dip could occur in the transmission spectrum, thus, a multiple-transparency-window system can be achieved (for the first time for graphene-based devices). More importantly, the transparency windows for both the quadrupole slot and the dolmen-like slot structures can be dynamically controlled over a broad frequency range by varying the Fermi energy levels of the graphene layer (through electrostatic gating). The proposed slot metamaterial structures with tunable single and multiple transparency windows could find potential applications in many areas such as multiple-wavelength slow-light devices, active plasmonic switching, and optical sensing.

Windows of sensitivity to toxic chemicals in the motor effects development.

PubMed

Ingber, Susan Z; Pohl, Hana R

2016-02-01

Many chemicals currently used are known to elicit nervous system effects. In addition, approximately 2000 new chemicals introduced annually have not yet undergone neurotoxicity testing. This review concentrated on motor development effects associated with exposure to environmental neurotoxicants to help identify critical windows of exposure and begin to assess data needs based on a subset of chemicals thoroughly reviewed by the Agency for Toxic Substances and Disease Registry (ATSDR) in Toxicological Profiles and Addenda. Multiple windows of sensitivity were identified that differed based on the maturity level of the neurological system at the time of exposure, as well as dose and exposure duration. Similar but distinct windows were found for both motor activity (GD 8-17 [rats], GD 12-14 and PND 3-10 [mice]) and motor function performance (insufficient data for rats, GD 12-17 [mice]). Identifying specific windows of sensitivity in animal studies was hampered by study designs oriented towards detection of neurotoxicity that occurred at any time throughout the developmental process. In conclusion, while this investigation identified some critical exposure windows for motor development effects, it demonstrates a need for more acute duration exposure studies based on neurodevelopmental windows, particularly during the exposure periods identified in this review. Published by Elsevier Inc.

Windows of sensitivity to toxic chemicals in the motor effects development✩

PubMed Central

Ingber, Susan Z.; Pohl, Hana R.

2017-01-01

Many chemicals currently used are known to elicit nervous system effects. In addition, approximately 2000 new chemicals introduced annually have not yet undergone neurotoxicity testing. This review concentrated on motor development effects associated with exposure to environmental neurotoxicants to help identify critical windows of exposure and begin to assess data needs based on a subset of chemicals thoroughly reviewed by the Agency for Toxic Substances and Disease Registry (ATSDR) in Toxicological Profiles and Addenda. Multiple windows of sensitivity were identified that differed based on the maturity level of the neurological system at the time of exposure, as well as dose and exposure duration. Similar but distinct windows were found for both motor activity (GD 8–17 [rats], GD 12–14 and PND 3–10 [mice]) and motor function performance (insufficient data for rats, GD 12–17 [mice]). Identifying specific windows of sensitivity in animal studies was hampered by study designs oriented towards detection of neurotoxicity that occurred at any time throughout the developmental process. In conclusion, while this investigation identified some critical exposure windows for motor development effects, it demonstrates a need for more acute duration exposure studies based on neurodevelopmental windows, particularly during the exposure periods identified in this review. PMID:26686904

SwarmSight: Measuring the Temporal Progression of Animal Group Activity Levels from Natural Scene and Laboratory Videos

PubMed Central

Birgiolas, Justas; Jernigan, Christopher M.; Smith, Brian H.; Crook, Sharon M.

2016-01-01

We describe SwarmSight (available at: https://github.com/justasb/SwarmSight), a novel, open-source, Microsoft Windows software tool for quantitative assessment of the temporal progression of animal group activity levels from recorded videos. The tool utilizes a background subtraction machine vision algorithm and provides an activity metric that can be used to quantitatively assess and compare animal group behavior. Here we demonstrate the tool utility by analyzing defensive bee behavior as modulated by alarm pheromones, wild bird feeding onset and interruption, and cockroach nest finding activity. While more sophisticated, commercial software packages are available, SwarmSight provides a low-cost, open-source, and easy-to-use alternative that is suitable for a wide range of users, including minimally trained research technicians and behavioral science undergraduate students in classroom laboratory settings. PMID:27130170

Extracting heading and temporal range from optic flow: Human performance issues

NASA Technical Reports Server (NTRS)

Kaiser, Mary K.; Perrone, John A.; Stone, Leland; Banks, Martin S.; Crowell, James A.

1993-01-01

Pilots are able to extract information about their vehicle motion and environmental structure from dynamic transformations in the out-the-window scene. In this presentation, we focus on the information in the optic flow which specifies vehicle heading and distance to objects in the environment, scaled to a temporal metric. In particular, we are concerned with modeling how the human operators extract the necessary information, and what factors impact their ability to utilize the critical information. In general, the psychophysical data suggest that the human visual system is fairly robust to degradations in the visual display, e.g., reduced contrast and resolution or restricted field of view. However, extraneous motion flow, i.e., introduced by sensor rotation, greatly compromises human performance. The implications of these models and data for enhanced/synthetic vision systems are discussed.

Event-Based Tone Mapping for Asynchronous Time-Based Image Sensor

PubMed Central

Simon Chane, Camille; Ieng, Sio-Hoi; Posch, Christoph; Benosman, Ryad B.

2016-01-01

The asynchronous time-based neuromorphic image sensor ATIS is an array of autonomously operating pixels able to encode luminance information with an exceptionally high dynamic range (>143 dB). This paper introduces an event-based methodology to display data from this type of event-based imagers, taking into account the large dynamic range and high temporal accuracy that go beyond available mainstream display technologies. We introduce an event-based tone mapping methodology for asynchronously acquired time encoded gray-level data. A global and a local tone mapping operator are proposed. Both are designed to operate on a stream of incoming events rather than on time frame windows. Experimental results on real outdoor scenes are presented to evaluate the performance of the tone mapping operators in terms of quality, temporal stability, adaptation capability, and computational time. PMID:27642275

Two-step phase-shifting SPIDER

NASA Astrophysics Data System (ADS)

Zheng, Shuiqin; Cai, Yi; Pan, Xinjian; Zeng, Xuanke; Li, Jingzhen; Li, Ying; Zhu, Tianlong; Lin, Qinggang; Xu, Shixiang

2016-09-01

Comprehensive characterization of ultrafast optical field is critical for ultrashort pulse generation and its application. This paper combines two-step phase-shifting (TSPS) into the spectral phase interferometry for direct electric-field reconstruction (SPIDER) to improve the reconstruction of ultrafast optical-fields. This novel SPIDER can remove experimentally the dc portion occurring in traditional SPIDER method by recording two spectral interferograms with π phase-shifting. As a result, the reconstructed results are much less disturbed by the time delay between the test pulse replicas and the temporal widths of the filter window, thus more reliable. What is more, this SPIDER can work efficiently even the time delay is so small or the measured bandwidth is so narrow that strong overlap happens between the dc and ac portions, which allows it to be able to characterize the test pulses with complicated temporal/spectral structures or narrow bandwidths.

Decoding visual object categories from temporal correlations of ECoG signals.

PubMed

Majima, Kei; Matsuo, Takeshi; Kawasaki, Keisuke; Kawai, Kensuke; Saito, Nobuhito; Hasegawa, Isao; Kamitani, Yukiyasu

2014-04-15

How visual object categories are represented in the brain is one of the key questions in neuroscience. Studies on low-level visual features have shown that relative timings or phases of neural activity between multiple brain locations encode information. However, whether such temporal patterns of neural activity are used in the representation of visual objects is unknown. Here, we examined whether and how visual object categories could be predicted (or decoded) from temporal patterns of electrocorticographic (ECoG) signals from the temporal cortex in five patients with epilepsy. We used temporal correlations between electrodes as input features, and compared the decoding performance with features defined by spectral power and phase from individual electrodes. While using power or phase alone, the decoding accuracy was significantly better than chance, correlations alone or those combined with power outperformed other features. Decoding performance with correlations was degraded by shuffling the order of trials of the same category in each electrode, indicating that the relative time series between electrodes in each trial is critical. Analysis using a sliding time window revealed that decoding performance with correlations began to rise earlier than that with power. This earlier increase in performance was replicated by a model using phase differences to encode categories. These results suggest that activity patterns arising from interactions between multiple neuronal units carry additional information on visual object categories. Copyright © 2013 Elsevier Inc. All rights reserved.

In-vitro perforation of the round window membrane via direct 3-D printed microneedles.

PubMed

Aksit, Aykut; Arteaga, Daniel N; Arriaga, Miguel; Wang, Xun; Watanabe, Hirobumi; Kasza, Karen E; Lalwani, Anil K; Kysar, Jeffrey W

2018-06-08

The cochlea, or inner ear, is a space fully enclosed within the temporal bone of the skull, except for two membrane-covered portals connecting it to the middle ear space. One of these portals is the round window, which is covered by the Round Window Membrane (RWM). A longstanding clinical goal is to reliably and precisely deliver therapeutics into the cochlea to treat a plethora of auditory and vestibular disorders. Standard of care for several difficult-to-treat diseases calls for injection of a therapeutic substance through the tympanic membrane into the middle ear space, after which a portion of the substance diffuses across the RWM into the cochlea. The efficacy of this technique is limited by an inconsistent rate of molecular transport across the RWM. A solution to this problem involves the introduction of one or more microscopic perforations through the RWM to enhance the rate and reliability of diffusive transport. This paper reports the use of direct 3D printing via Two-Photon Polymerization (2PP) lithography to fabricate ultra-sharp polymer microneedles specifically designed to perforate the RWM. The microneedle has tip radius of 500 nm and shank radius of 50 μ m, and perforates the guinea pig RWM with a mean force of 1.19 mN. The resulting perforations performed in vitro are lens-shaped with major axis equal to the microneedle shank diameter and minor axis about 25% of the major axis, with mean area 1670 μ m 2 . The major axis is aligned with the direction of the connective fibers within the RWM. The fibers were separated along their axes without ripping or tearing of the RWM suggesting the main failure mechanism to be fiber-to-fiber decohesion. The small perforation area along with fiber-to-fiber decohesion are promising indicators that the perforations would heal readily following in vivo experiments. These results establish a foundation for the use of Two-Photon Polymerization lithography as a means to fabricate microneedles to perforate the RWM and other similar membranes.

Brain functional connectivity during the experience of thought blocks in schizophrenic patients with persistent auditory verbal hallucinations: an EEG study.

PubMed

Angelopoulos, Elias; Koutsoukos, Elias; Maillis, Antonis; Papadimitriou, George N; Stefanis, Costas

2014-03-01

Thought blocks (TBs) are characterized by regular interruptions in the stream of thought. Outward signs are abrupt and repeated interruptions in the flow of conversation or actions while subjective experience is that of a total and uncontrollable emptying of the mind. In the very limited bibliography regarding TB, the phenomenon is thought to be conceptualized as a disturbance of consciousness that can be attributed to stoppages of continuous information processing due to an increase in the volume of information to be processed. In an attempt to investigate potential expression of the phenomenon on the functional properties of electroencephalographic (EEG) activity, an EEG study was contacted in schizophrenic patients with persisting auditory verbal hallucinations (AVHs) who additionally exhibited TBs. In this case, we hypothesized that the persistent and dense AVHs could serve the role of an increased information flow that the brain is unable to process, a condition that is perceived by the person as TB. Phase synchronization analyses performed on EEG segments during the experience of TBs showed that synchrony values exhibited a long-range common mode of coupling (grouped behavior) among the left temporal area and the remaining central and frontal brain areas. These common synchrony-fluctuation schemes were observed for 0.5 to 2s and were detected in a 4-s window following the estimated initiation of the phenomenon. The observation was frequency specific and detected in the broad alpha band region (6-12Hz). The introduction of synchrony entropy (SE) analysis applied on the cumulative synchrony distribution showed that TB states were characterized by an explicit preference of the system to be functioned at low values of synchrony, while the synchrony values are broadly distributed during the recovery state. Our results indicate that during TB states, the phase locking of several brain areas were converged uniformly in a narrow band of low synchrony values and in a distinct time window, impeding thus the ability of the system to recruit and to process information during this time window. Copyright © 2014 Elsevier B.V. All rights reserved.

Temporal resolution in individuals with neurological disorders

PubMed Central

Rabelo, Camila Maia; Weihing, Jeffrey A; Schochat, Eliane

2015-01-01

OBJECTIVE: Temporal processing refers to the ability of the central auditory nervous system to encode and detect subtle changes in acoustic signals. This study aims to investigate the temporal resolution ability of individuals with mesial temporal sclerosis and to determine the sensitivity and specificity of the gaps-in-noise test in identifying this type of lesion. METHOD: This prospective study investigated differences in temporal resolution between 30 individuals with normal hearing and without neurological lesions (G1) and 16 individuals with both normal hearing and mesial temporal sclerosis (G2). Test performances were compared, and the sensitivity and specificity were calculated. RESULTS: There was no difference in gap detection thresholds between the two groups, although G1 revealed better average thresholds than G2 did. The sensitivity and specificity of the gaps-in-noise test for neurological lesions were 68% and 98%, respectively. CONCLUSIONS: Temporal resolution ability is compromised in individuals with neurological lesions caused by mesial temporal sclerosis. The gaps-in-noise test was shown to be a sensitive and specific measure of central auditory dysfunction in these patients. PMID:26375561

The route to chaos for the Kuramoto-Sivashinsky equation

NASA Technical Reports Server (NTRS)

Papageorgiou, Demetrios T.; Smyrlis, Yiorgos

1990-01-01

The results of extensive numerical experiments of the spatially periodic initial value problem for the Kuramoto-Sivashinsky equation. This paper is concerned with the asymptotic nonlinear dynamics at the dissipation parameter decreases and spatio-temporal chaos sets in. To this end the initial condition is taken to be the same for all numerical experiments (a single sine wave is used) and the large time evolution of the system is followed numerically. Numerous computations were performed to establish the existence of windows, in parameter space, in which the solution has the following characteristics as the viscosity is decreased: a steady fully modal attractor to a steady bimodal attractor to another steady fully modal attractor to a steady trimodal attractor to a periodic attractor, to another steady fully modal attractor, to another periodic attractor, to a steady tetramodal attractor, to another periodic attractor having a full sequence of period-doublings (in parameter space) to chaos. Numerous solutions are presented which provide conclusive evidence of the period-doubling cascades which precede chaos for this infinite-dimensional dynamical system. These results permit a computation of the length of subwindows which in turn provide an estimate for their successive ratios as the cascade develops. A calculation based on the numerical results is also presented to show that the period doubling sequences found here for the Kuramoto-Sivashinsky equation, are in complete agreement with Feigenbaum's universal constant of 4,669201609... . Some preliminary work shows several other windows following the first chaotic one including periodic, chaotic, and a steady octamodal window; however, the windows shrink significantly in size to enable concrete quantitative conclusions to be made.

GONe: Software for estimating effective population size in species with generational overlap

USGS Publications Warehouse

Coombs, J.A.; Letcher, B.H.; Nislow, K.H.

2012-01-01

GONe is a user-friendly, Windows-based program for estimating effective size (N e) in populations with overlapping generations. It uses the Jorde-Ryman modification to the temporal method to account for age structure in populations. This method requires estimates of age-specific survival and birth rate and allele frequencies measured in two or more consecutive cohorts. Allele frequencies are acquired by reading in genotypic data from files formatted for either GENEPOP or TEMPOFS. For each interval between consecutive cohorts, N e is estimated at each locus and over all loci. Furthermore, N e estimates are output for three different genetic drift estimators (F s, F c and F k). Confidence intervals are derived from a chi-square distribution with degrees of freedom equal to the number of independent alleles. GONe has been validated over a wide range of N e values, and for scenarios where survival and birth rates differ between sexes, sex ratios are unequal and reproductive variances differ. GONe is freely available for download at. ?? 2011 Blackwell Publishing Ltd.

Hierarchical genetic interactions between FOXG1 and LHX2 regulate the formation of the cortical hem in the developing telencephalon.

PubMed

Godbole, Geeta; Shetty, Ashwin S; Roy, Achira; D'Souza, Leora; Chen, Bin; Miyoshi, Goichi; Fishell, Gordon; Tole, Shubha

2018-01-09

During forebrain development, a telencephalic organizer called the cortical hem is crucial for inducing hippocampal fate in adjacent cortical neuroepithelium. How the hem is restricted to its medial position is therefore a fundamental patterning issue. Here, we demonstrate that Foxg1 - Lhx2 interactions are crucial for the formation of the hem. Loss of either gene causes a region of the cortical neuroepithelium to transform into hem. We show that FOXG1 regulates Lhx2 expression in the cortical primordium. In the absence of Foxg1 , the presence of Lhx2 is sufficient to suppress hem fate, and hippocampal markers appear selectively in Lhx2 -expressing regions. FOXG1 also restricts the temporal window in which loss of Lhx2 results in a transformation of cortical primordium into hem. Therefore, Foxg1 and Lhx2 form a genetic hierarchy in the spatiotemporal regulation of cortical hem specification and positioning, and together ensure the normal development of this hippocampal organizer. © 2018. Published by The Company of Biologists Ltd.

Introduction and application of the multiscale coefficient of variation analysis.

PubMed

Abney, Drew H; Kello, Christopher T; Balasubramaniam, Ramesh

2017-10-01

Quantifying how patterns of behavior relate across multiple levels of measurement typically requires long time series for reliable parameter estimation. We describe a novel analysis that estimates patterns of variability across multiple scales of analysis suitable for time series of short duration. The multiscale coefficient of variation (MSCV) measures the distance between local coefficient of variation estimates within particular time windows and the overall coefficient of variation across all time samples. We first describe the MSCV analysis and provide an example analytical protocol with corresponding MATLAB implementation and code. Next, we present a simulation study testing the new analysis using time series generated by ARFIMA models that span white noise, short-term and long-term correlations. The MSCV analysis was observed to be sensitive to specific parameters of ARFIMA models varying in the type of temporal structure and time series length. We then apply the MSCV analysis to short time series of speech phrases and musical themes to show commonalities in multiscale structure. The simulation and application studies provide evidence that the MSCV analysis can discriminate between time series varying in multiscale structure and length.

UVA-induced reset of hydroxyl radical ultradian rhythm improves temporal lipid production in Chlorella vulgaris.

PubMed

Balan, Ranjini; Suraishkumar, G K

2014-01-01

We report for the first time that the endogenous, pseudo-steady-state, specific intracellular levels of the hydroxyl radical (si-OH) oscillate in an ultradian fashion (model system: the microalga, Chlorella vulgaris), and also characterize the various rhythm parameters. The ultradian rhythm in the endogenous levels of the si-OH occurred with an approximately 6 h period in the daily cycle of light and darkness. Further, we expected that the rhythm reset to a shorter period could rapidly switch the cellular redox states that could favor lipid accumulation. We reset the endogenous rhythm through entrainment with UVA radiation, and generated two new ultradian rhythms with periods of approximately 2.97 h and 3.8 h in the light phase and dark phase, respectively. The reset increased the window of maximum lipid accumulation from 6 h to 12 h concomitant with the onset of the ultradian rhythms. Further, the saturated fatty acid content increased approximately to 80% of total lipid content, corresponding to the peak maxima of the hydroxyl radical levels in the reset rhythm. © 2014 American Institute of Chemical Engineers.

NONO couples the circadian clock to the cell cycle.

PubMed

Kowalska, Elzbieta; Ripperger, Juergen A; Hoegger, Dominik C; Bruegger, Pascal; Buch, Thorsten; Birchler, Thomas; Mueller, Anke; Albrecht, Urs; Contaldo, Claudio; Brown, Steven A

2013-01-29

Mammalian circadian clocks restrict cell proliferation to defined time windows, but the mechanism and consequences of this interrelationship are not fully understood. Previously we identified the multifunctional nuclear protein NONO as a partner of circadian PERIOD (PER) proteins. Here we show that it also conveys circadian gating to the cell cycle, a connection surprisingly important for wound healing in mice. Specifically, although fibroblasts from NONO-deficient mice showed approximately normal circadian cycles, they displayed elevated cell doubling and lower cellular senescence. At a molecular level, NONO bound to the p16-Ink4A cell cycle checkpoint gene and potentiated its circadian activation in a PER protein-dependent fashion. Loss of either NONO or PER abolished this activation and circadian expression of p16-Ink4A and eliminated circadian cell cycle gating. In vivo, lack of NONO resulted in defective wound repair. Because wound healing defects were also seen in multiple circadian clock-deficient mouse lines, our results therefore suggest that coupling of the cell cycle to the circadian clock via NONO may be useful to segregate in temporal fashion cell proliferation from tissue organization.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mandage, Revati S.; McAteer, R. T. James, E-mail: mcateer@nmsu.edu

A magnetic power spectral analysis is performed on 53 solar active regions, observed from 2011 August to 2012 July. Magnetic field data obtained from the Helioseismic and Magnetic Imager, inverted as Active Region Patches, are used to study the evolution of the magnetic power index as each region rotates across the solar disk. Active regions are classified based on the numbers and sizes of solar flares they produce in order to study the relationship between flare productivity and the magnetic power index. The choice of window size and inertial range plays a key role in determining the correct magnetic powermore » index. The overall distribution of magnetic power indices has a range of 1.0–2.5. Flare-quiet regions peak at a value of 1.6. However, flare-productive regions peak at a value of 2.2. Overall, the histogram of the distribution of power indices of flare-productive active regions is well separated from flare-quiet active regions. Only 12% of flare-quiet regions exhibit an index greater than 2, whereas 90% of flare-productive regions exhibit an index greater than 2. Flare-quiet regions exhibit a high temporal variance (i.e., the index fluctuates between high and low values), whereas flare-productive regions maintain an index greater than 2 for several days. This shows the importance of including the temporal evolution of active regions in flare prediction studies, and highlights the potential of a 2–3 day prediction window for space weather applications.« less

The Workstation Approach to Laboratory Computing

PubMed Central

Crosby, P.A.; Malachowski, G.C.; Hall, B.R.; Stevens, V.; Gunn, B.J.; Hudson, S.; Schlosser, D.

1985-01-01

There is a need for a Laboratory Workstation which specifically addresses the problems associated with computing in the scientific laboratory. A workstation based on the IBM PC architecture and including a front end data acquisition system which communicates with a host computer via a high speed communications link; a new graphics display controller with hardware window management and window scrolling; and an integrated software package is described.

Wavenumber selection based analysis in Raman spectroscopy improves skin cancer diagnostic specificity at high sensitivity levels (Conference Presentation)

NASA Astrophysics Data System (ADS)

Zhao, Jianhua; Zeng, Haishan; Kalia, Sunil; Lui, Harvey

2017-02-01

Background: Raman spectroscopy is a non-invasive optical technique which can measure molecular vibrational modes within tissue. A large-scale clinical study (n = 518) has demonstrated that real-time Raman spectroscopy could distinguish malignant from benign skin lesions with good diagnostic accuracy; this was validated by a follow-up independent study (n = 127). Objective: Most of the previous diagnostic algorithms have typically been based on analyzing the full band of the Raman spectra, either in the fingerprint or high wavenumber regions. Our objective in this presentation is to explore wavenumber selection based analysis in Raman spectroscopy for skin cancer diagnosis. Methods: A wavenumber selection algorithm was implemented using variably-sized wavenumber windows, which were determined by the correlation coefficient between wavenumbers. Wavenumber windows were chosen based on accumulated frequency from leave-one-out cross-validated stepwise regression or least and shrinkage selection operator (LASSO). The diagnostic algorithms were then generated from the selected wavenumber windows using multivariate statistical analyses, including principal component and general discriminant analysis (PC-GDA) and partial least squares (PLS). A total cohort of 645 confirmed lesions from 573 patients encompassing skin cancers, precancers and benign skin lesions were included. Lesion measurements were divided into training cohort (n = 518) and testing cohort (n = 127) according to the measurement time. Result: The area under the receiver operating characteristic curve (ROC) improved from 0.861-0.891 to 0.891-0.911 and the diagnostic specificity for sensitivity levels of 0.99-0.90 increased respectively from 0.17-0.65 to 0.20-0.75 by selecting specific wavenumber windows for analysis. Conclusion: Wavenumber selection based analysis in Raman spectroscopy improves skin cancer diagnostic specificity at high sensitivity levels.

An Evidence-Based Forensic Taxonomy of Windows Phone Communication Apps.

PubMed

Cahyani, Niken Dwi Wahyu; Martini, Ben; Choo, Kim-Kwang Raymond; Ab Rahman, Nurul Hidayah; Ashman, Helen

2018-05-01

Communication apps can be an important source of evidence in a forensic investigation (e.g., in the investigation of a drug trafficking or terrorism case where the communications apps were used by the accused persons during the transactions or planning activities). This study presents the first evidence-based forensic taxonomy of Windows Phone communication apps, using an existing two-dimensional Android forensic taxonomy as a baseline. Specifically, 30 Windows Phone communication apps, including Instant Messaging (IM) and Voice over IP (VoIP) apps, are examined. Artifacts extracted using physical acquisition are analyzed, and seven digital evidence objects of forensic interest are identified, namely: Call Log, Chats, Contacts, Locations, Installed Applications, SMSs and User Accounts. Findings from this study would help to facilitate timely and effective forensic investigations involving Windows Phone communication apps. © 2017 American Academy of Forensic Sciences.

Experimental and Numerical Examination of the Thermal Transmittance of High Performance Window Frames

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gustavsen Ph.D., Arild; Goudey, Howdy; Kohler, Christian

2010-06-17

While window frames typically represent 20-30percent of the overall window area, their impact on the total window heat transfer rates may be much larger. This effect is even greater in low-conductance (highly insulating) windows which incorporate very low conductance glazings. Developing low-conductance window frames requires accurate simulation tools for product research and development. The Passivhaus Institute in Germany states that windows (glazing and frames, combined) should have U-values not exceeding 0.80 W/(m??K). This has created a niche market for highly insulating frames, with frame U-values typically around 0.7-1.0 W/(m2 cdot K). The U-values reported are often based on numerical simulationsmore » according to international simulation standards. It is prudent to check the accuracy of these calculation standards, especially for high performance products before more manufacturers begin to use them to improve other product offerings. In this paper the thermal transmittance of five highly insulating window frames (three wooden frames, one aluminum frame and one PVC frame), found from numerical simulations and experiments, are compared. Hot box calorimeter results are compared with numerical simulations according to ISO 10077-2 and ISO 15099. In addition CFD simulations have been carried out, in order to use the most accurate tool available to investigate the convection and radiation effects inside the frame cavities. Our results show that available tools commonly used to evaluate window performance, based on ISO standards, give good overall agreement, but specific areas need improvement.« less

A new concept of imaging system: telescope windows

NASA Astrophysics Data System (ADS)

Bourgenot, Cyril; Cowie, Euan; Young, Laura; Love, Gordon; Girkin, John; Courtial, Johannes

2018-02-01

A Telescope window is a novel concept of transformation-optics consisting of an array of micro-telescopes, in our configuration, of a Galilean type. When the array is considered as one multifaceted device, it acts as a traditional Galilean telescope with distinctive and attractive properties such as compactness and modularity. Each lenslet, can in principle, be independently designed for a specific optical function. In this paper, we report on the design, manufacture and prototyping, by diamond precision machining, of 2 concepts of telescope windows, and discuss both their performances and limitations with a view to use them as potential low vision aid devices to support patients with macular degeneration.

Field and laboratory studies of moving and temporally variable noise sources (aircraft); perception of location, movement, and direction.

PubMed

Gunn, W J; Shigehisa, T; Shepherd, W T

1979-10-01

The conditions were examined under which more valid and reliable estimates could be made of the effects of aircraft noise on people. In Exper. 1, 12 Ss in 2 different houses directly under the flight path of a major airport (JFK) indicated 1 of 12 possible flight paths (4 directly overhead and 8 to one side) for each of 3 jet aircraft flyovers: 3% of cases in House A and 56% in House B (which had open windows) were correctly identified. Despite judgment inaccuracy, Ss were more than moderately certain of the correctness of their judgments. In Exper. II. Ss either inside or outside of 2 houses in Wallops Station, Virginia, indicated on diagrams the direction of flyovers. Each of 4 aircraft (Boeing 737, C-54, UE-1 helicopter, Queenaire) made 8 flyovers directly over the houses and 8 to one side. Windows were either open or closed. All flyovers and conditions were counterbalanced. All sound sources under all conditions were usually judged to be overhead and moving, but for Ss indoors with windows closed the to-the-side flyovers were judged to be off to the side in 24% of cases. Outdoor Ss reported correct direction in 75% of cases while indoor Ss were correct in only 25% (windows open) or 18% (windows closed). Judgments "to the side" were significantly better (p = less than .02) with windows open vs closed, while with windows closed judgments were significantly better (p = less than .05) for flyovers overhead vs to the side. In Exper. III, Ss localized in azimuth and in the vertical plane recorded noises (10 1-oct noise bands of CF = 28.12 c/s - 14.4kc/s, spoken voice, and jet aircraft takeoffs and landings), presented through 1, 2, or 4 floor-level loudspeakers at each corner of a simulated living room (4.2 x 5.4m)built inside an IAC soundproof room. Aircraft noises presented by 4 loudspeakers were localized as "directly" overhead 80% of the time and "generally overhead" about 90% of the time; other sounds were so localized about 50% and 75% of the time respectively. Through only 2 loudspeakers, aircraft noises were localized 25-36 degrees above horizontal. Implications are that acoustic realism can be achieved in simulated aircraft overflights and that future laboratory noise-effects research should incorporate the required conditions.

Temporally flexible feedback signal to foveal cortex for peripheral object recognition

PubMed Central

Fan, Xiaoxu; Wang, Lan; Shao, Hanyu; Kersten, Daniel; He, Sheng

2016-01-01

Recent studies have shown that information from peripherally presented images is present in the human foveal retinotopic cortex, presumably because of feedback signals. We investigated this potential feedback signal by presenting noise in fovea at different object–noise stimulus onset asynchronies (SOAs), whereas subjects performed a discrimination task on peripheral objects. Results revealed a selective impairment of performance when foveal noise was presented at 250-ms SOA, but only for tasks that required comparing objects’ spatial details, suggesting a task- and stimulus-dependent foveal processing mechanism. Critically, the temporal window of foveal processing was shifted when mental rotation was required for the peripheral objects, indicating that the foveal retinotopic processing is not automatically engaged at a fixed time following peripheral stimulation; rather, it occurs at a stage when detailed information is required. Moreover, fMRI measurements using multivoxel pattern analysis showed that both image and object category-relevant information of peripheral objects was represented in the foveal cortex. Taken together, our results support the hypothesis of a temporally flexible feedback signal to the foveal retinotopic cortex when discriminating objects in the visual periphery. PMID:27671651

Adherent Raindrop Modeling, Detectionand Removal in Video.

PubMed

You, Shaodi; Tan, Robby T; Kawakami, Rei; Mukaigawa, Yasuhiro; Ikeuchi, Katsushi

2016-09-01

Raindrops adhered to a windscreen or window glass can significantly degrade the visibility of a scene. Modeling, detecting and removing raindrops will, therefore, benefit many computer vision applications, particularly outdoor surveillance systems and intelligent vehicle systems. In this paper, a method that automatically detects and removes adherent raindrops is introduced. The core idea is to exploit the local spatio-temporal derivatives of raindrops. To accomplish the idea, we first model adherent raindrops using law of physics, and detect raindrops based on these models in combination with motion and intensity temporal derivatives of the input video. Having detected the raindrops, we remove them and restore the images based on an analysis that some areas of raindrops completely occludes the scene, and some other areas occlude only partially. For partially occluding areas, we restore them by retrieving as much as possible information of the scene, namely, by solving a blending function on the detected partially occluding areas using the temporal intensity derivative. For completely occluding areas, we recover them by using a video completion technique. Experimental results using various real videos show the effectiveness of our method.

From bird to sparrow: Learning-induced modulations in fine-grained semantic discrimination.

PubMed

De Meo, Rosanna; Bourquin, Nathalie M-P; Knebel, Jean-François; Murray, Micah M; Clarke, Stephanie

2015-09-01

Recognition of environmental sounds is believed to proceed through discrimination steps from broad to more narrow categories. Very little is known about the neural processes that underlie fine-grained discrimination within narrow categories or about their plasticity in relation to newly acquired expertise. We investigated how the cortical representation of birdsongs is modulated by brief training to recognize individual species. During a 60-minute session, participants learned to recognize a set of birdsongs; they improved significantly their performance for trained (T) but not control species (C), which were counterbalanced across participants. Auditory evoked potentials (AEPs) were recorded during pre- and post-training sessions. Pre vs. post changes in AEPs were significantly different between T and C i) at 206-232ms post stimulus onset within a cluster on the anterior part of the left superior temporal gyrus; ii) at 246-291ms in the left middle frontal gyrus; and iii) 512-545ms in the left middle temporal gyrus as well as bilaterally in the cingulate cortex. All effects were driven by weaker activity for T than C species. Thus, expertise in discriminating T species modulated early stages of semantic processing, during and immediately after the time window that sustains the discrimination between human vs. animal vocalizations. Moreover, the training-induced plasticity is reflected by the sharpening of a left lateralized semantic network, including the anterior part of the temporal convexity and the frontal cortex. Training to identify birdsongs influenced, however, also the processing of C species, but at a much later stage. Correct discrimination of untrained sounds seems to require an additional step which results from lower-level features analysis such as apperception. We therefore suggest that the access to objects within an auditory semantic category is different and depends on subject's level of expertise. More specifically, correct intra-categorical auditory discrimination for untrained items follows the temporal hierarchy and transpires in a late stage of semantic processing. On the other hand, correct categorization of individually trained stimuli occurs earlier, during a period contemporaneous with human vs. animal vocalization discrimination, and involves a parallel semantic pathway requiring expertise. Copyright © 2015 Elsevier Inc. All rights reserved.

Modeling spatial and temporal variability of residential air exchange rates for the Near-Road Exposures and Effects of Urban Air Pollutants Study (NEXUS).

PubMed

Breen, Michael S; Burke, Janet M; Batterman, Stuart A; Vette, Alan F; Godwin, Christopher; Croghan, Carry W; Schultz, Bradley D; Long, Thomas C

2014-11-07

Air pollution health studies often use outdoor concentrations as exposure surrogates. Failure to account for variability of residential infiltration of outdoor pollutants can induce exposure errors and lead to bias and incorrect confidence intervals in health effect estimates. The residential air exchange rate (AER), which is the rate of exchange of indoor air with outdoor air, is an important determinant for house-to-house (spatial) and temporal variations of air pollution infiltration. Our goal was to evaluate and apply mechanistic models to predict AERs for 213 homes in the Near-Road Exposures and Effects of Urban Air Pollutants Study (NEXUS), a cohort study of traffic-related air pollution exposures and respiratory effects in asthmatic children living near major roads in Detroit, Michigan. We used a previously developed model (LBL), which predicts AER from meteorology and questionnaire data on building characteristics related to air leakage, and an extended version of this model (LBLX) that includes natural ventilation from open windows. As a critical and novel aspect of our AER modeling approach, we performed a cross validation, which included both parameter estimation (i.e., model calibration) and model evaluation, based on daily AER measurements from a subset of 24 study homes on five consecutive days during two seasons. The measured AER varied between 0.09 and 3.48 h(-1) with a median of 0.64 h(-1). For the individual model-predicted and measured AER, the median absolute difference was 29% (0.19 h‑1) for both the LBL and LBLX models. The LBL and LBLX models predicted 59% and 61% of the variance in the AER, respectively. Daily AER predictions for all 213 homes during the three year study (2010-2012) showed considerable house-to-house variations from building leakage differences, and temporal variations from outdoor temperature and wind speed fluctuations. Using this novel approach, NEXUS will be one of the first epidemiology studies to apply calibrated and home-specific AER models, and to include the spatial and temporal variations of AER for over 200 individual homes across multiple years into an exposure assessment in support of improving risk estimates.

Generation of 360 ps laser pulse with 3 J energy by stimulated Brillouin scattering with a nonfocusing scheme.

PubMed

Zhu, Xuehua; Wang, Yulei; Lu, Zhiwei; Zhang, Hengkang

2015-09-07

A new technique for generating high energy sub-400 picosecond laser pulses is presented in this paper. The temporally super-Gaussian-shaped laser pulses are used as light source. When the forward pump is reflected by the rear window of SBS cell, the frequency component that fulfills Brillouin frequency shift in its sideband spectrum works as a seed and excites SBS, which results in efficient compression of the incident pump pulse. First the pulse compression characteristics of 20th-order super-Gaussian temporally shaped pulses with 5 ns duration are analyzed theoretically. Then experiment is carried out with a narrow-band high power Nd:glass laser system at the double-frequency and wavelength of 527 nm which delivers 5 ns super-Gaussian temporally shaped pulses with single pulse energy over 10 J. FC-40 is used as the active SBS medium for its brief phonon lifetime and high power capacity. In the experiment, the results agree well with the numerical calculations. With pump energy of 5.36J, the compression of pulse duration from 5 ns to 360 ps is obtained. The output energy is 3.02 J and the peak-power is magnified 8.3 times. Moreover, the compressed pulse shows a high stability because it is initiated by the feedback of rear window rather than the thermal noise distributing inside the medium. This technique of generating high energy hundred picosecond laser pulses has simple structure and is easy to operate, and it also can be scaled to higher energy pulse compression in the future. Meanwhile, it should also be taken into consideration that in such a nonfocusing scheme, the noise-initiated SBS would increase the distortion on the wavefront of Stokes beam to some extent, and the pump energy should be controlled below the threshold of noise-initiated SBS.

Mitigating Uncertainty from Vegetation Spatial Complexity with Highly Portable Lidar

NASA Astrophysics Data System (ADS)

Paynter, I.; Schaaf, C.; Peri, F.; Saenz, E. J.; Genest, D.; Strahler, A. H.; Li, Z.

2015-12-01

To fully utilize the excellent spatial coverage and temporal resolution offered by satellite resources for estimating ecological variables, fine-scale observations are required for comparison, calibration and validation. Lidar instruments have proved effective in estimating the properties of vegetation components of ecosystems, but they are often challenged by occlusion, especially in structurally complex and spatially fragmented ecosystems such as tropical forests. Increasing the range of view angles, both horizontally and vertically, by increasing the number of scans, can mitigate occlusion. However these scans must occur within the window of temporal stability for the ecosystem and vegetation property being measured. The Compact Biomass Lidar (CBL) is a TLS optimized for portability and scanning speed, developed and operated by University of Massachusetts Boston. This 905nm wavelength scanner achieves an angular resolution of 0.25 degrees at a rate of 33 seconds per scan. The ability to acquire many scans within narrow windows of temporal stability for ecological variables has facilitated the more complete investigation of ecosystem structural characteristics, and their expression as a function of view angle. The lightweight CBL has facilitated the use of alternative deployment platforms including towers, trams and masts, allowing analysis of the vertical structure of ecosystems, even in highly enclosed environments such as the sub-canopy of tropical forests where aerial vehicles cannot currently operate. We will present results from view angle analyses of lidar surveys of tropical rainforest in La Selva, Costa Rica where the CBL was deployed at heights up to 10m in Carbono long-term research plots utilizing a portable mast, and on a 25m stationary tower; and temperate forest at Harvard Forest, Massachusetts, USA, where the CBL has been deployed biannually at long-term research plots of hardwood and hemlock, as well as at heights of up to 25m utilizing a stationary tower.

Feature Selection, Flaring Size and Time-to-Flare Prediction Using Support Vector Regression, and Automated Prediction of Flaring Behavior Based on Spatio-Temporal Measures Using Hidden Markov Models

NASA Astrophysics Data System (ADS)

Al-Ghraibah, Amani

Solar flares release stored magnetic energy in the form of radiation and can have significant detrimental effects on earth including damage to technological infrastructure. Recent work has considered methods to predict future flare activity on the basis of quantitative measures of the solar magnetic field. Accurate advanced warning of solar flare occurrence is an area of increasing concern and much research is ongoing in this area. Our previous work 111] utilized standard pattern recognition and classification techniques to determine (classify) whether a region is expected to flare within a predictive time window, using a Relevance Vector Machine (RVM) classification method. We extracted 38 features which describing the complexity of the photospheric magnetic field, the result classification metrics will provide the baseline against which we compare our new work. We find a true positive rate (TPR) of 0.8, true negative rate (TNR) of 0.7, and true skill score (TSS) of 0.49. This dissertation proposes three basic topics; the first topic is an extension to our previous work [111, where we consider a feature selection method to determine an appropriate feature subset with cross validation classification based on a histogram analysis of selected features. Classification using the top five features resulting from this analysis yield better classification accuracies across a large unbalanced dataset. In particular, the feature subsets provide better discrimination of the many regions that flare where we find a TPR of 0.85, a TNR of 0.65 sightly lower than our previous work, and a TSS of 0.5 which has an improvement comparing with our previous work. In the second topic, we study the prediction of solar flare size and time-to-flare using support vector regression (SVR). When we consider flaring regions only, we find an average error in estimating flare size of approximately half a GOES class. When we additionally consider non-flaring regions, we find an increased average error of approximately 3/4 a GOES class. We also consider thresholding the regressed flare size for the experiment containing both flaring and non-flaring regions and find a TPR. of 0.69 and a TNR of 0.86 for flare prediction, consistent with our previous studies of flare prediction using the same magnetic complexity features. The results for both of these size regression experiments are consistent across a wide range of predictive time windows, indicating that the magnetic complexity features may be persistent in appearance long before flare activity. This conjecture is supported by our larger error rates of some 40 hours in the time-to-flare regression problem. The magnetic complexity features considered here appear to have discriminative potential for flare size, but their persistence in time makes them less discriminative for the time-to-flare problem. We also study the prediction of solar flare size and time-to-flare using two temporal features, namely the ▵- and ▵-▵-features, the same average size and time-to-flare regression error are found when these temporal features are used in size and time-to-flare prediction. In the third topic, we study the temporal evolution of active region magnetic fields using Hidden Markov Models (HMMs) which is one of the efficient temporal analyses found in literature. We extracted 38 features which describing the complexity of the photospheric magnetic field. These features are converted into a sequence of symbols using k-nearest neighbor search method. We study many parameters before prediction; like the length of the training window Wtrain which denotes to the number of history images use to train the flare and non-flare HMMs, and number of hidden states Q. In training phase, the model parameters of the HMM of each category are optimized so as to best describe the training symbol sequences. In testing phase, we use the best flare and non-flare models to predict/classify active regions as a flaring or non-flaring region using a sliding window method. The best prediction result is found where the length of the history training images are 15 images (i.e., Wtrain= 15) and the length of the sliding testing window is less than or equal to W train, the best result give a TPR of 0.79 consistent with previous flare prediction work, TNR of 0.87 arid TSS of 0.66, where both are higher than our previous flare prediction work. We find that the best number of hidden states which can describe the temporal evolution of the solar ARs is equal to five states, at the same time, a close resultant metrics are found using different number of states.

2.5-month-old infants' reasoning about when objects should and should not be occluded.

PubMed

Aguiar, A; Baillargeon, R

1999-09-01

The present research examined 2.5-month-old infants' reasoning about occlusion events. Three experiments investigated infants' ability to predict whether an object should remain continuously hidden or become temporarily visible when passing behind an occluder with an opening in its midsection. In Experiment 1, the infants were habituated to a short toy mouse that moved back and forth behind a screen. Next, the infants saw two test events that were identical to the habituation event except that a portion of the screen's midsection was removed to create a large window. In one event (high-window event), the window extended from the screen's upper edge; the mouse was shorter than the bottom of the window and thus did not become visible when passing behind the screen. In the other event (low-window event), the window extended from the screen's lower edge; although the mouse was shorter than the top of the window and hence should have become fully visible when passing behind the screen, it never appeared in the window. The infants tended to look equally at the high- and low-window events, suggesting that they were not surprised when the mouse failed to appear in the low window. However, positive results were obtained in Experiment 2 when the low-window event was modified: a portion of the screen above the window was removed so that the left and right sections of the screen were no longer connected (two-screens event). The infants looked reliably longer at the two-screens than at the high-window event. Together, the results of Experiments 1 and 2 suggested that, at 2.5 months of age, infants possess only very limited expectations about when objects should and should not be occluded. Specifically, infants expect objects (1) to become visible when passing between occluders and (2) to remain hidden when passing behind occluders, irrespective of whether these have openings extending from their upper or lower edges. Experiment 3 provided support for this interpretation. The implications of these findings for models of the origins and development of infants' knowledge about occlusion events are discussed. Copyright 1999 Academic Press.

Myocardial perfusion magnetic resonance imaging using sliding-window conjugate-gradient highly constrained back-projection reconstruction for detection of coronary artery disease.

PubMed

Ma, Heng; Yang, Jun; Liu, Jing; Ge, Lan; An, Jing; Tang, Qing; Li, Han; Zhang, Yu; Chen, David; Wang, Yong; Liu, Jiabin; Liang, Zhigang; Lin, Kai; Jin, Lixin; Bi, Xiaoming; Li, Kuncheng; Li, Debiao

2012-04-15

Myocardial perfusion magnetic resonance imaging (MRI) with sliding-window conjugate-gradient highly constrained back-projection reconstruction (SW-CG-HYPR) allows whole left ventricular coverage, improved temporal and spatial resolution and signal/noise ratio, and reduced cardiac motion-related image artifacts. The accuracy of this technique for detecting coronary artery disease (CAD) has not been determined in a large number of patients. We prospectively evaluated the diagnostic performance of myocardial perfusion MRI with SW-CG-HYPR in patients with suspected CAD. A total of 50 consecutive patients who were scheduled for coronary angiography with suspected CAD underwent myocardial perfusion MRI with SW-CG-HYPR at 3.0 T. The perfusion defects were interpreted qualitatively by 2 blinded observers and were correlated with x-ray angiographic stenoses ≥50%. The prevalence of CAD was 56%. In the per-patient analysis, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of SW-CG-HYPR was 96% (95% confidence interval 82% to 100%), 82% (95% confidence interval 60% to 95%), 87% (95% confidence interval 70% to 96%), 95% (95% confidence interval 74% to100%), and 90% (95% confidence interval 82% to 98%), respectively. In the per-vessel analysis, the corresponding values were 98% (95% confidence interval 91% to 100%), 89% (95% confidence interval 80% to 94%), 86% (95% confidence interval 76% to 93%), 99% (95% confidence interval 93% to 100%), and 93% (95% confidence interval 89% to 97%), respectively. In conclusion, myocardial perfusion MRI using SW-CG-HYPR allows whole left ventricular coverage and high resolution and has high diagnostic accuracy in patients with suspected CAD. Copyright © 2012 Elsevier Inc. All rights reserved.

Liver enhancement in healthy dogs after gadoxetic acid administration during dynamic contrast-enhanced magnetic resonance imaging.

PubMed

Borusewicz, P; Stańczyk, E; Kubiak, K; Spużak, J; Glińska-Suchocka, K; Jankowski, M; Nicpoń, J; Podgórski, P

2018-05-01

Dynamic contrast enhanced (DCE)-magnetic resonance imaging (MRI) consists of acquisition of native baseline images, followed by a series of acquisitions performed during and after administration of a contrast medium. DCE-MRI, in conjunction with hepatobiliary-specific contrast media, such as gadoxetic acid (GD-EOB-DTPA), allows for precise characterisation of the enhancement pattern of the hepatic parenchyma following administration of the contrast agent. The aim of the study was to assess the pattern of temporal resolution contrast enhancement of the hepatic parenchyma following administration of GD-EOB-DTPA and to determine the optimal time window for post-contrast assessment of the liver. The study was carried out on eight healthy beagle dogs. MRI was performed using a 1.5T scanner. The imaging protocol included T1 weighted (T1-W) gradient echo (GRE), T2 weighted (T2-W) turbo spin echo (TSE) and dynamic T1-W GRE sequences. The dynamic T1-W sequence was performed using single 10mm thick slices. Regions of interest (ROIs) were chosen and the signal intensity curves were calculated for quantitative image analysis. The mean time to peak for all dogs was 26min. The plateau phase lasted on average 21min. A gradual decrease in the signal intensity of the hepatic parenchyma was observed in all dogs. A DCE-MRI enhancement pattern of the hepatic parenchyma was evident in dogs following the administration of a GD-EOB-DTPA, establishing baseline data for an optimal time window between 26 and 41min after administration of the contrast agent. Copyright © 2018 Elsevier Ltd. All rights reserved.

Transdiagnostic and diagnosis-specific dynamic functional connectivity anchored in the right anterior insula in major depressive disorder and bipolar depression.

PubMed

Pang, Yajing; Chen, Heng; Wang, Yifeng; Long, Zhiliang; He, Zongling; Zhang, Huangbin; Liao, Wei; Cui, Qian; Chen, Huafu

2018-07-13

Dysfunctional and abnormal functional connectivity in the right anterior insula (rAI) may underlie the pathophysiology of depression episode in bipolar disorder (BD) and of major depressive disorder (MDD). In this study, we examined the dynamic functional connectivity (dFC) of the rAI of 30 patients with BD, 30 patients with MDD, and 30 healthy controls. In the functional separation of rAI, the right dorsal AI (rdAI) and ventral AI (rvAI) were defined as seed regions. Sliding-window correlation of rAI subregions was implemented to measure the variance of dFC. BD and MDD shared abnormality in dFC, such as the decreased dFC between the rvAI and right ventrolateral prefrontal cortex. Others were disorder-specific and included MDD-related increases in dFC between the rvAI and right precuneus, temporal pole, and left dorsolateral prefrontal cortex. This observation is in stark contrast to BD-related increases in the dFC between the rdAI and left inferior parietal lobule and right middle occipital gyrus. The abnormal dFC of rAI shared by BD and MDD supports the importance of rAI in the common pathophysiology of these disorders. Meanwhile, disorder-specific abnormalities that attribute to the dorsal and ventral divisions of rAI can be used as biomarkers to differentiate BD from MDD. Copyright © 2018 Elsevier Inc. All rights reserved.

Listeners are maximally flexible in updating phonetic beliefs over time.

PubMed

Saltzman, David; Myers, Emily

2018-04-01

Perceptual learning serves as a mechanism for listenexrs to adapt to novel phonetic information. Distributional tracking theories posit that this adaptation occurs as a result of listeners accumulating talker-specific distributional information about the phonetic category in question (Kleinschmidt & Jaeger, 2015, Psychological Review, 122). What is not known is how listeners build these talker-specific distributions; that is, if they aggregate all information received over a certain time period, or if they rely more heavily upon the most recent information received and down-weight older, consolidated information. In the present experiment, listeners were exposed to four interleaved blocks of a lexical decision task and a phonetic categorization task in which the lexical decision blocks were designed to bias perception in opposite directions along a "s"-"sh" continuum. Listeners returned several days later and completed the identical task again. Evidence was consistent with listeners using a relatively short temporal window of integration at the individual session level. Namely, in each individual session, listeners' perception of a "s"-"sh" contrast was biased by the information in the immediately preceding lexical decision block, and there was no evidence that listeners summed their experience with the talker over the entire session. Similarly, the magnitude of the bias effect did not change between sessions, consistent with the idea that talker-specific information remains flexible, even after consolidation. In general, results suggest that listeners are maximally flexible when considering how to categorize speech from a novel talker.

The time course of episodic associative retrieval: electrophysiological correlates of cued recall of unimodal and crossmodal pair-associate learning.

PubMed

Tibon, Roni; Levy, Daniel A

2014-03-01

Little is known about the time course of processes supporting episodic cued recall. To examine these processes, we recorded event-related scalp electrical potentials during episodic cued recall following pair-associate learning of unimodal object-picture pairs and crossmodal object-picture and sound pairs. Successful cued recall of unimodal associates was characterized by markedly early scalp potential differences over frontal areas, while cued recall of both unimodal and crossmodal associates were reflected by subsequent differences recorded over frontal and parietal areas. Notably, unimodal cued recall success divergences over frontal areas were apparent in a time window generally assumed to reflect the operation of familiarity but not recollection processes, raising the possibility that retrieval success effects in that temporal window may reflect additional mnemonic processes beyond familiarity. Furthermore, parietal scalp potential recall success differences, which did not distinguish between crossmodal and unimodal tasks, seemingly support attentional or buffer accounts of posterior parietal mnemonic function but appear to constrain signal accumulation, expectation, or representational accounts.

A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging

PubMed Central

Antaris, Alexander L.; Chen, Hao; Diao, Shuo; Ma, Zhuoran; Zhang, Zhe; Zhu, Shoujun; Wang, Joy; Lozano, Alexander X.; Fan, Quli; Chew, Leila; Zhu, Mark; Cheng, Kai; Hong, Xuechuan; Dai, Hongjie; Cheng, Zhen

2017-01-01

Fluorescence imaging in the second near-infrared window (NIR-II) allows visualization of deep anatomical features with an unprecedented degree of clarity. NIR-II fluorophores draw from a broad spectrum of materials spanning semiconducting nanomaterials to organic molecular dyes, yet unfortunately all water-soluble organic molecules with >1,000 nm emission suffer from low quantum yields that have limited temporal resolution and penetration depth. Here, we report tailoring the supramolecular assemblies of protein complexes with a sulfonated NIR-II organic dye (CH-4T) to produce a brilliant 110-fold increase in fluorescence, resulting in the highest quantum yield molecular fluorophore thus far. The bright molecular complex allowed for the fastest video-rate imaging in the second NIR window with ∼50-fold reduced exposure times at a fast 50 frames-per-second (FPS) capable of resolving mouse cardiac cycles. In addition, we demonstrate that the NIR-II molecular complexes are superior to clinically approved ICG for lymph node imaging deep within the mouse body. PMID:28524850

Mechanochemistry for shock wave energy dissipation

NASA Astrophysics Data System (ADS)

Shaw, William L.; Ren, Yi; Moore, Jeffrey S.; Dlott, Dana D.

2017-01-01

Using a laser-driven flyer-plate apparatus to launch 75 μm thick Al flyers up to 2.8 km/s, we developed a technique for detecting the attenuation of shock waves by mechanically-driven chemical reactions. The attenuating sample was spread on an ultrathin Au mirror deposited onto a glass window having a known Hugoniot. As shock energy exited the sample and passed through the mirror, into the glass, photonic Doppler velocimetry monitored the velocity profile of the ultrathin mirror. Knowing the window Hugoniot, the velocity profile could be quantitatively converted into a shock energy flux or fluence. The flux gave the temporal profile of the shock front, and showed how the shock front was reshaped by passing through the dissipative medium. The fluence, the time-integrated flux, showed how much shock energy was transmitted through the sample. Samples consisted of microgram quantities of carefully engineered organic compounds selected for their potential to undergo negative-volume chemistry. Post mortem analytical methods were used to confirm that shock dissipation was associated with shock-induced chemical reactions.

Laser vibrometer measurements and middle ear prostheses

NASA Astrophysics Data System (ADS)

Flock, Stephen T.; Dornhoffer, John; Ferguson, Scott

1997-05-01

One of us has developed an improved partial ossicular replacement prosthesis that is easier to implant and, based on pilot clinical measurements, results in better high-frequency hearing as compared to patients receiving one of the alternative prostheses. It is hypothesized that the primary reason for this is because of the relatively light weight (about 25 mg) and low compliance of the prosthesis, which could conceivably result in better high frequency vibrational characteristics. The purpose of our initial work was to develop an instrument suitable for objectively testing the vibrational characteristics of prostheses. We have developed a laser based device suitable for measuring the vibrational characteristics of the oval window or other structures of the middle ear. We have tested this device using a piezoelectric transducer excited at audio frequencies, as well as on the oval window in human temporal bones harvested from cadavers. The results illustrate that it is possible to non-invasively monitor the vibrational characteristics of anatomic structures with a very inexpensive photonic device.

Effect of excitation direction on cochlear macro-mechanics during bone conduction stimulation

NASA Astrophysics Data System (ADS)

Kamieniecki, Konrad; Tudruj, Sylwester; Piechna, Janusz; Borkowski, Paweł

2018-05-01

In many instances of hearing loss, audiological improvement can be made via direct excitation of a temporal bone (i.e., bone conduction). In order to design better and more efficient devices, the macro-mechanics of the bone conduction hearing pathway must be better understood. Based on previous empirical work, numerical models are useful. In this work, we present results of a time-domain Fluid Structure Interaction model that describes stimulation of the bone conduction pathway. The cochlea was modelled as uncoiled and consisted of an oval window, a round window, a basilar membrane and a helicotrema. In order to monitor pressure waves in the perilymph, the fluid was considered compressible. The excitation, in form of sinusoidal velocity, was applied to the cochlea bony walls. The system was excited in three perpendicular directions: along the basilar membrane, perpendicularly to the membrane and transversely to the membrane. The numerical simulation examined which stimulation direction maximally excited the basilar membrane, the pressure distributions for each excitation direction, and the associated mechanics.

Low-level water vapor fields from the VISSR atmospheric sounder (VAS) split window channels at 11 and 12 microns. [visible infrared spin scan radiometer

NASA Technical Reports Server (NTRS)

Chesters, D.; Uccellini, L.; Robinson, W.

1982-01-01

A series of high-resolution water vapor fields were derived from the 11 and 12 micron channels of the VISSR Atmospheric Sounder (VAS) on GOES-5. The low-level tropospheric moisture content was separated from the surface and atmospheric radiances by using the differential adsorption across the 'split window' along with the average air temperature from imbedded radiosondes. Fields of precipitable water are presented in a time sequence of five false color images taken over the United States at 3-hour intervals. Vivid subsynoptic and mesoscale patterns evolve at 15 km horizontal resolution over the 12-hour observing period. Convective cloud formations develop from several areas of enhanced low-level water vapor, especially where the vertical water vapor gradient relatively strong. Independent verification at radiosonde sites indicates fairly good absolute accuracy, and the spatial and temporal continuity of the water vapor features indicates very good relative accuracy. Residual errors are dominated by radiometer noise and unresolved clouds.

A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Antaris, Alexander L.; Chen, Hao; Diao, Shuo

Fluorescence imaging in the second near-infrared window (NIR-II) allows visualization of deep anatomical features with an unprecedented degree of clarity. NIR-II fluorophores draw from a broad spectrum of materials spanning semiconducting nanomaterials to organic molecular dyes, yet unfortunately all water-soluble organic molecules with 41,000 nm emission suffer from low quantum yields that have limited temporal resolution and penetration depth. We report tailoring the supramolecular assemblies of protein complexes with a sulfonated NIR-II organic dye (CH-4T) to produce a brilliant 110-fold increase in fluorescence, resulting in the highest quantum yield molecular fluorophore thus far. The bright molecular complex allowed for themore » fastest video-rate imaging in the second NIR window with B50-fold reduced exposure times at a fast 50 frames-per-second (FPS) capable of resolving mouse cardiac cycles. Additionally, we demonstrate that the NIR-II molecular complexes are superior to clinically approved ICG for lymph node imaging deep within the mouse body.« less

A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging

DOE PAGES

Antaris, Alexander L.; Chen, Hao; Diao, Shuo; ...

2017-05-19

Fluorescence imaging in the second near-infrared window (NIR-II) allows visualization of deep anatomical features with an unprecedented degree of clarity. NIR-II fluorophores draw from a broad spectrum of materials spanning semiconducting nanomaterials to organic molecular dyes, yet unfortunately all water-soluble organic molecules with 41,000 nm emission suffer from low quantum yields that have limited temporal resolution and penetration depth. We report tailoring the supramolecular assemblies of protein complexes with a sulfonated NIR-II organic dye (CH-4T) to produce a brilliant 110-fold increase in fluorescence, resulting in the highest quantum yield molecular fluorophore thus far. The bright molecular complex allowed for themore » fastest video-rate imaging in the second NIR window with B50-fold reduced exposure times at a fast 50 frames-per-second (FPS) capable of resolving mouse cardiac cycles. Additionally, we demonstrate that the NIR-II molecular complexes are superior to clinically approved ICG for lymph node imaging deep within the mouse body.« less

Traces of Drosophila Memory

PubMed Central

Davis, Ronald L.

2012-01-01

Summary Studies using functional cellullar imaging of living flies have identified six memory traces that form in the olfactory nervous system after conditioning with odors. These traces occur in distinct nodes of the olfactory nervous system, form and disappear across different windows of time, and are detected in the imaged neurons as increased calcium influx or synaptic release in response to the conditioned odor. Three traces form at, or near acquisition and co-exist with short-term behavioral memory. One trace forms with a delay after learning and co-exists with intermediate-term behavioral memory. Two traces form many hours after acquisition and co-exist with long-term behavioral memory. The transient memory traces may support behavior across the time-windows of their existence. The experimental approaches for dissecting memory formation in the fly, ranging from the molecular to the systems, make it an ideal system for dissecting the logic by which the nervous system organizes and stores different temporal forms of memory. PMID:21482352

Development of an EMCCD for LIDAR applications

NASA Astrophysics Data System (ADS)

De Monte, B.; Bell, R. T.

2017-11-01

A novel detector, incorporating e2v's EMCCD (L3VisionTM) [1] technology for use in LIDAR (Light Detection And Ranging) applications has been designed, manufactured and characterised. The most critical performance aspect was the requirement to collect charge from a 120μm square detection area for a 667ns temporal sampling window, with low crosstalk between successive samples, followed by signal readout with sub-electron effective noise. Additional requirements included low dark signal, high quantum efficiency at the 355nm laser wavelength and the ability to handle bright laser echoes, without corruption of the much fainter useful signals. The detector architecture used high speed charge binning to combine signal from each sampling window into a single charge packet. This was then passed through a multiplication register (EMCCD) operating with a typical gain of 100X to a conventional charge detection circuit. The detector achieved a typical quantum efficiency of 80% and a total noise in darkness of < 0.5 electrons rms. Development of the detector was supported by ESA.

Improved moving window cross-spectral analysis for resolving large temporal seismic velocity changes in permafrost

DOE PAGES

James, S. R.; Knox, H. A.; Abbott, R. E.; ...

2017-04-13

Cross correlations of seismic noise can potentially record large changes in subsurface velocity due to permafrost dynamics and be valuable for long-term Arctic monitoring. We applied seismic interferometry, using moving window cross-spectral analysis (MWCS), to 2 years of ambient noise data recorded in central Alaska to investigate whether seismic noise could be used to quantify relative velocity changes due to seasonal active-layer dynamics. The large velocity changes (>75%) between frozen and thawed soil caused prevalent cycle-skipping which made the method unusable in this setting. We developed an improved MWCS procedure which uses a moving reference to measure daily velocity variationsmore » that are then accumulated to recover the full seasonal change. This approach reduced cycle-skipping and recovered a seasonal trend that corresponded well with the timing of active-layer freeze and thaw. Lastly, this improvement opens the possibility of measuring large velocity changes by using MWCS and permafrost monitoring by using ambient noise.« less

Effects of temporal variability in ground data collection on classification accuracy

USGS Publications Warehouse

Hoch, G.A.; Cully, J.F.

1999-01-01

This research tested whether the timing of ground data collection can significantly impact the accuracy of land cover classification. Ft. Riley Military Reservation, Kansas, USA was used to test this hypothesis. The U.S. Army's Land Condition Trend Analysis (LCTA) data annually collected at military bases was used to ground truth disturbance patterns. Ground data collected over an entire growing season and data collected one year after the imagery had a kappa statistic of 0.33. When using ground data from only within two weeks of image acquisition the kappa statistic improved to 0.55. Potential sources of this discrepancy are identified. These data demonstrate that there can be significant amounts of land cover change within a narrow time window on military reservations. To accurately conduct land cover classification at military reservations, ground data need to be collected in as narrow a window of time as possible and be closely synchronized with the date of the satellite imagery.

Depth-time interpolation of feature trends extracted from mobile microelectrode data with kernel functions.

PubMed

Wong, Stephen; Hargreaves, Eric L; Baltuch, Gordon H; Jaggi, Jurg L; Danish, Shabbar F

2012-01-01

Microelectrode recording (MER) is necessary for precision localization of target structures such as the subthalamic nucleus during deep brain stimulation (DBS) surgery. Attempts to automate this process have produced quantitative temporal trends (feature activity vs. time) extracted from mobile MER data. Our goal was to evaluate computational methods of generating spatial profiles (feature activity vs. depth) from temporal trends that would decouple automated MER localization from the clinical procedure and enhance functional localization in DBS surgery. We evaluated two methods of interpolation (standard vs. kernel) that generated spatial profiles from temporal trends. We compared interpolated spatial profiles to true spatial profiles that were calculated with depth windows, using correlation coefficient analysis. Excellent approximation of true spatial profiles is achieved by interpolation. Kernel-interpolated spatial profiles produced superior correlation coefficient values at optimal kernel widths (r = 0.932-0.940) compared to standard interpolation (r = 0.891). The choice of kernel function and kernel width resulted in trade-offs in smoothing and resolution. Interpolation of feature activity to create spatial profiles from temporal trends is accurate and can standardize and facilitate MER functional localization of subcortical structures. The methods are computationally efficient, enhancing localization without imposing additional constraints on the MER clinical procedure during DBS surgery. Copyright © 2012 S. Karger AG, Basel.

Temporal bone dissection simulator for training pediatric otolaryngology surgeons

NASA Astrophysics Data System (ADS)

Tabrizi, Pooneh R.; Sang, Hongqiang; Talari, Hadi F.; Preciado, Diego; Monfaredi, Reza; Reilly, Brian; Arikatla, Sreekanth; Enquobahrie, Andinet; Cleary, Kevin

2017-03-01

Cochlear implantation is the standard of care for infants born with severe hearing loss. Current guidelines approve the surgical placement of implants as early as 12 months of age. Implantation at a younger age poses a greater surgical challenge since the underdeveloped mastoid tip, along with thin calvarial bone, creates less room for surgical navigation and can result in increased surgical risk. We have been developing a temporal bone dissection simulator based on actual clinical cases for training otolaryngology fellows in this delicate procedure. The simulator system is based on pre-procedure CT (Computed Tomography) images from pediatric infant cases (<12 months old) at our hospital. The simulator includes: (1) simulation engine to provide the virtual reality of the temporal bone surgery environment, (2) a newly developed haptic interface for holding the surgical drill, (3) an Oculus Rift to provide a microscopic-like view of the temporal bone surgery, and (4) user interface to interact with the simulator through the Oculus Rift and the haptic device. To evaluate the system, we have collected 10 representative CT data sets and segmented the key structures: cochlea, round window, facial nerve, and ossicles. The simulator will present these key structures to the user and warn the user if needed by continuously calculating the distances between the tip of surgical drill and the key structures.

Increased biomagnetic activity in the ventral pathway in mild cognitive impairment.

PubMed

Maestú, F; Campo, P; Del Río, D; Moratti, S; Gil-Gregorio, P; Fernández, A; Capilla, A; Ortiz, T

2008-06-01

Mild cognitive impairment (MCI) patients represent an intermediary state between healthy aging and dementia. MCI activation profiles, recorded during a memory task, have been studied either through high spatial resolution or high temporal resolution techniques. However, little is known about the benefit of combining both dimensions. Here, we investigate, by means of magnetoencephalography (MEG), whether spatio-temporal profiles of neuromagnetic activity could differentiate between MCI and age-matched elderly participants. Taking the advantage of the high temporal resolution and good spatial resolution of MEG, neuromagnetic activity from 15 elderly MCI patients and 20 age-matched controls was recorded during the performance of a modified version of the Sternberg paradigm. Behavioral performance was similar in both groups. A between group analysis revealed that MCI patients showed bilateral higher activity in the ventral pathway, in both the target and the non-target stimuli. A within-group analysis of the target stimuli, indicates a lack of asymmetry through all late latency windows in both groups. MCI patients showed a compensatory mechanism represented by an increased bilateral activity of the ventral pathway in order to achieve a behavioral performance similar to the control group. This spatio-temporal pattern of activity could be another tool to differentiate between healthy aging and MCI patients.