High speed multiphoton imaging

NASA Astrophysics Data System (ADS)

Li, Yongxiao; Brustle, Anne; Gautam, Vini; Cockburn, Ian; Gillespie, Cathy; Gaus, Katharina; Lee, Woei Ming

2016-12-01

Intravital multiphoton microscopy has emerged as a powerful technique to visualize cellular processes in-vivo. Real time processes revealed through live imaging provided many opportunities to capture cellular activities in living animals. The typical parameters that determine the performance of multiphoton microscopy are speed, field of view, 3D imaging and imaging depth; many of these are important to achieving data from in-vivo. Here, we provide a full exposition of the flexible polygon mirror based high speed laser scanning multiphoton imaging system, PCI-6110 card (National Instruments) and high speed analog frame grabber card (Matrox Solios eA/XA), which allows for rapid adjustments between frame rates i.e. 5 Hz to 50 Hz with 512 × 512 pixels. Furthermore, a motion correction algorithm is also used to mitigate motion artifacts. A customized control software called Pscan 1.0 is developed for the system. This is then followed by calibration of the imaging performance of the system and a series of quantitative in-vitro and in-vivo imaging in neuronal tissues and mice.

High-speed cell recognition algorithm for ultrafast flow cytometer imaging system.

PubMed

Zhao, Wanyue; Wang, Chao; Chen, Hongwei; Chen, Minghua; Yang, Sigang

2018-04-01

An optical time-stretch flow imaging system enables high-throughput examination of cells/particles with unprecedented high speed and resolution. A significant amount of raw image data is produced. A high-speed cell recognition algorithm is, therefore, highly demanded to analyze large amounts of data efficiently. A high-speed cell recognition algorithm consisting of two-stage cascaded detection and Gaussian mixture model (GMM) classification is proposed. The first stage of detection extracts cell regions. The second stage integrates distance transform and the watershed algorithm to separate clustered cells. Finally, the cells detected are classified by GMM. We compared the performance of our algorithm with support vector machine. Results show that our algorithm increases the running speed by over 150% without sacrificing the recognition accuracy. This algorithm provides a promising solution for high-throughput and automated cell imaging and classification in the ultrafast flow cytometer imaging platform. (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE).

High-speed cell recognition algorithm for ultrafast flow cytometer imaging system

NASA Astrophysics Data System (ADS)

Zhao, Wanyue; Wang, Chao; Chen, Hongwei; Chen, Minghua; Yang, Sigang

2018-04-01

An optical time-stretch flow imaging system enables high-throughput examination of cells/particles with unprecedented high speed and resolution. A significant amount of raw image data is produced. A high-speed cell recognition algorithm is, therefore, highly demanded to analyze large amounts of data efficiently. A high-speed cell recognition algorithm consisting of two-stage cascaded detection and Gaussian mixture model (GMM) classification is proposed. The first stage of detection extracts cell regions. The second stage integrates distance transform and the watershed algorithm to separate clustered cells. Finally, the cells detected are classified by GMM. We compared the performance of our algorithm with support vector machine. Results show that our algorithm increases the running speed by over 150% without sacrificing the recognition accuracy. This algorithm provides a promising solution for high-throughput and automated cell imaging and classification in the ultrafast flow cytometer imaging platform.

High-speed imaging system for observation of discharge phenomena

NASA Astrophysics Data System (ADS)

Tanabe, R.; Kusano, H.; Ito, Y.

2008-11-01

A thin metal electrode tip instantly changes its shape into a sphere or a needlelike shape in a single electrical discharge of high current. These changes occur within several hundred microseconds. To observe these high-speed phenomena in a single discharge, an imaging system using a high-speed video camera and a high repetition rate pulse laser was constructed. A nanosecond laser, the wavelength of which was 532 nm, was used as the illuminating source of a newly developed high-speed video camera, HPV-1. The time resolution of our system was determined by the laser pulse width and was about 80 nanoseconds. The system can take one hundred pictures at 16- or 64-microsecond intervals in a single discharge event. A band-pass filter at 532 nm was placed in front of the camera to block the emission of the discharge arc at other wavelengths. Therefore, clear images of the electrode were recorded even during the discharge. If the laser was not used, only images of plasma during discharge and thermal radiation from the electrode after discharge were observed. These results demonstrate that the combination of a high repetition rate and a short pulse laser with a high speed video camera provides a unique and powerful method for high speed imaging.

High-speed photoacoustic imaging using an LED-based photoacoustic imaging system

NASA Astrophysics Data System (ADS)

Sato, Naoto; Kuniyil Ajith Singh, Mithun; Shigeta, Yusuke; Hanaoka, Takamitsu; Agano, Toshitaka

2018-02-01

Recently we developed a multispectral LED-based photoacoustic/ultrasound imaging system (AcousticX) and have been continuously working on its technical/functional improvements. AcousticX is a linear array ultrasound transducer (128 elements, 10 MHz)-based system in which LED arrays (selectable wavelengths, pulse repetition frequency: 4 kHz, pulse width: tunable from 40 - 100 ns) are fixed on both sides of the transducer to illuminate the tissue for photoacoustic imaging. The ultrasound/photoacoustic data from all 128 elements can be simultaneously acquired, processed and displayed. We already demonstrated our system's capability to perform photoacoustic/ultrasound imaging for dynamic imaging of the tissue at a frame rate of 10 Hz (for example to visualize the pulsation of arteries in vivo in human subjects). In this work, we present the development of a new high-speed imaging mode in AcousticX. In this mode, instead of toggling between ultrasound and photoacoustic measurements, it is possible to continuously acquire only photoacoustic data for 1.5 seconds with a time interval of 1 ms. With this improvement, we can record photoacoustic signals from the whole aperture (38 mm) at fast rate and can be reviewed later at different speeds for analyzing dynamic changes in the photoacoustic signals. We believe that AcousticX with this new high-speed mode opens up a feasible technical path for multiple dynamic studies, for example one which focus on imaging the response of voltage sensitive dyes. We envisage to improve the acquisition speed further in future for exploring ultra-high-speed applications.

Image restoration method based on Hilbert transform for full-field optical coherence tomography

NASA Astrophysics Data System (ADS)

Na, Jihoon; Choi, Woo June; Choi, Eun Seo; Ryu, Seon Young; Lee, Byeong Ha

2008-01-01

A full-field optical coherence tomography (FF-OCT) system utilizing a simple but novel image restoration method suitable for a high-speed system is demonstrated. An en-face image is retrieved from only two phase-shifted interference fringe images through using the mathematical Hilbert transform. With a thermal light source, a high-resolution FF-OCT system having axial and transverse resolutions of 1 and 2.2 μm, respectively, was implemented. The feasibility of the proposed scheme is confirmed by presenting the obtained en-face images of biological samples such as a piece of garlic and a gold beetle. The proposed method is robust to the error in the amount of the phase shift and does not leave residual fringes. The use of just two interference images and the strong immunity to phase errors provide great advantages in the imaging speed and the system design flexibility of a high-speed high-resolution FF-OCT system.

New-style defect inspection system of film

NASA Astrophysics Data System (ADS)

Liang, Yan; Liu, Wenyao; Liu, Ming; Lee, Ronggang

2002-09-01

An inspection system has been developed for on-line detection of film defects, which bases on combination of photoelectric imaging and digital image processing. The system runs in high speed of maximum 60m/min. Moving film is illuminated by LED array which emits even infrared (peak wavelength λp=940nm), and infrared images are obtained with a high quality and high speed CCD camera. The application software based on Visual C++6.0 under Windows processes images in real time by means of such algorithms as median filter, edge detection and projection, etc. The system is made up of four modules, which are introduced in detail in the paper. On-line experiment results shows that the inspection system can recognize defects precisely in high speed and run reliably in practical application.

High-speed adaptive optics for imaging of the living human eye

PubMed Central

Yu, Yongxin; Zhang, Tianjiao; Meadway, Alexander; Wang, Xiaolin; Zhang, Yuhua

2015-01-01

The discovery of high frequency temporal fluctuation of human ocular wave aberration dictates the necessity of high speed adaptive optics (AO) correction for high resolution retinal imaging. We present a high speed AO system for an experimental adaptive optics scanning laser ophthalmoscope (AOSLO). We developed a custom high speed Shack-Hartmann wavefront sensor and maximized the wavefront detection speed based upon a trade-off among the wavefront spatial sampling density, the dynamic range, and the measurement sensitivity. We examined the temporal dynamic property of the ocular wavefront under the AOSLO imaging condition and improved the dual-thread AO control strategy. The high speed AO can be operated with a closed-loop frequency up to 110 Hz. Experiment results demonstrated that the high speed AO system can provide improved compensation for the wave aberration up to 30 Hz in the living human eye. PMID:26368408

Investigations of high-speed digital imaging of low-light-level events using pulsed near-infrared laser light sources

NASA Astrophysics Data System (ADS)

Jantzen, Connie; Slagle, Rick

1997-05-01

The distinction between exposure time and sample rate is often the first point raised in any discussion of high speed imaging. Many high speed events require exposure times considerably shorter than those that can be achieved solely by the sample rate of the camera, where exposure time equals 1/sample rate. Gating, a method of achieving short exposure times in digital cameras, is often difficult to achieve for exposure time requirements shorter than 100 microseconds. This paper discusses the advantages and limitations of using the short duration light pulse of a near infrared laser with high speed digital imaging systems. By closely matching the output wavelength of the pulsed laser to the peak near infrared response of current sensors, high speed image capture can be accomplished at very low (visible) light levels of illumination. By virtue of the short duration light pulse, adjustable to as short as two microseconds, image capture of very high speed events can be achieved at relatively low sample rates of less than 100 pictures per second, without image blur. For our initial investigations, we chose a ballistic subject. The results of early experimentation revealed the limitations of applying traditional ballistic imaging methods when using a pulsed infrared lightsource with a digital imaging system. These early disappointing results clarified the need to further identify the unique system characteristics of the digital imager and pulsed infrared combination. It was also necessary to investigate how the infrared reflectance and transmittance of common materials affects the imaging process. This experimental work yielded a surprising, successful methodology which will prove useful in imaging ballistic and weapons tests, as well as forensics, flow visualizations, spray pattern analyses, and nocturnal animal behavioral studies.

Stereomotion speed perception is contrast dependent

NASA Technical Reports Server (NTRS)

Brooks, K.

2001-01-01

The effect of contrast on the perception of stimulus speed for stereomotion and monocular lateral motion was investigated for successive matches in random-dot stimuli. The familiar 'Thompson effect'--that a reduction in contrast leads to a reduction in perceived speed--was found in similar proportions for both binocular images moving in depth, and for monocular images translating laterally. This result is consistent with the idea that the monocular motion system has a significant input to the stereomotion system, and dominates the speed percept for approaching motion.

High-speed laser photoacoustic imaging system combined with a digital ultrasonic imaging platform

NASA Astrophysics Data System (ADS)

Zeng, Lvming; Liu, Guodong; Ji, Xuanrong; Ren, Zhong; Huang, Zhen

2009-07-01

As a new field of combined ultrasound/photoacoustic imaging in biomedical photonics research, we present and demonstrate a high-speed laser photoacoustic imaging system combined with digital ultrasound imaging platform. In the prototype system, a new B-mode digital ultrasonic imaging system is modified as the hardware platform with 384 vertical transducer elements. The centre resonance frequency of the piezoelectric transducer is 5.0 MHz with greater than 70% pulse-echo -6dB fractional bandwidth. The modular instrument of PCI-6541 is used as the hardware control centre of the testing system, which features 32 high-speed channels to build low-skew and multi-channel system. The digital photoacoustic data is transported into computer for subsequent reconstruction at 25 MHz clock frequency. Meantime, the software system for controlling and analyzing is correspondingly explored with LabVIEW language on virtual instrument platform. In the breast tissue experiment, the reconstructed image agrees well with the original sample, and the spatial resolution of the system can reach 0.2 mm with multi-element synthetic aperture focusing technique. Therefore, the system and method may have a significant value in improving early detecting level of cancer in the breast and other organs.

Design of light-small high-speed image data processing system

NASA Astrophysics Data System (ADS)

Yang, Jinbao; Feng, Xue; Li, Fei

2015-10-01

A light-small high speed image data processing system was designed in order to meet the request of image data processing in aerospace. System was constructed of FPGA, DSP and MCU (Micro-controller), implementing a video compress of 3 million pixels@15frames and real-time return of compressed image to the upper system. Programmable characteristic of FPGA, high performance image compress IC and configurable MCU were made best use to improve integration. Besides, hard-soft board design was introduced and PCB layout was optimized. At last, system achieved miniaturization, light-weight and fast heat dispersion. Experiments show that, system's multifunction was designed correctly and worked stably. In conclusion, system can be widely used in the area of light-small imaging.

Photoacoustics and speed-of-sound dual mode imaging with a long depth-of-field by using annular ultrasound array.

PubMed

Ding, Qiuning; Tao, Chao; Liu, Xiaojun

2017-03-20

Speed-of-sound and optical absorption reflect the structure and function of tissues from different aspects. A dual-mode microscopy system based on a concentric annular ultrasound array is proposed to simultaneously acquire the long depth-of-field images of speed-of-sound and optical absorption of inhomogeneous samples. First, speed-of-sound is decoded from the signal delay between each element of the annular array. The measured speed-of-sound could not only be used as an image contrast, but also improve the resolution and accuracy of spatial location of photoacoustic image in inhomogeneous acoustic media. Secondly, benefitting from dynamic focusing of annular array and the measured speed-of-sound, it is achieved an advanced acoustic-resolution photoacoustic microscopy with a precise position and a long depth-of-field. The performance of the dual-mode imaging system has been experimentally examined by using a custom-made annular array. The proposed dual-mode microscopy might have the significances in monitoring the biological physiological and pathological processes.

High-performance sub-terahertz transmission imaging system for food inspection

PubMed Central

Ok, Gyeongsik; Park, Kisang; Chun, Hyang Sook; Chang, Hyun-Joo; Lee, Nari; Choi, Sung-Wook

2015-01-01

Unlike X-ray systems, a terahertz imaging system can distinguish low-density materials in a food matrix. For applying this technique to food inspection, imaging resolution and acquisition speed ought to be simultaneously enhanced. Therefore, we have developed the first continuous-wave sub-terahertz transmission imaging system with a polygonal mirror. Using an f-theta lens and a polygonal mirror, beam scanning is performed over a range of 150 mm. For obtaining transmission images, the line-beam is incorporated with sample translation. The imaging system demonstrates that a pattern with 2.83 mm line-width at 210 GHz can be identified with a scanning speed of 80 mm/s. PMID:26137392

Wide-field high-speed space-division multiplexing optical coherence tomography using an integrated photonic device

PubMed Central

Huang, Yongyang; Badar, Mudabbir; Nitkowski, Arthur; Weinroth, Aaron; Tansu, Nelson; Zhou, Chao

2017-01-01

Space-division multiplexing optical coherence tomography (SDM-OCT) is a recently developed parallel OCT imaging method in order to achieve multi-fold speed improvement. However, the assembly of fiber optics components used in the first prototype system was labor-intensive and susceptible to errors. Here, we demonstrate a high-speed SDM-OCT system using an integrated photonic chip that can be reliably manufactured with high precisions and low per-unit cost. A three-layer cascade of 1 × 2 splitters was integrated in the photonic chip to split the incident light into 8 parallel imaging channels with ~3.7 mm optical delay in air between each channel. High-speed imaging (~1s/volume) of porcine eyes ex vivo and wide-field imaging (~18.0 × 14.3 mm2) of human fingers in vivo were demonstrated with the chip-based SDM-OCT system. PMID:28856055

High-speed image processing system and its micro-optics application

NASA Astrophysics Data System (ADS)

Ohba, Kohtaro; Ortega, Jesus C. P.; Tanikawa, Tamio; Tanie, Kazuo; Tajima, Kenji; Nagai, Hiroshi; Tsuji, Masataka; Yamada, Shigeru

2003-07-01

In this paper, a new application system with high speed photography, i.e. an observational system for the tele-micro-operation, has been proposed with a dynamic focusing system and a high-speed image processing system using the "Depth From Focus (DFF)" criteria. In micro operation, such as for the microsurgery, DNA operation and etc., the small depth of a focus on the microscope makes bad observation. For example, if the focus is on the object, the actuator cannot be seen with the microscope. On the other hand, if the focus is on the actuator, the object cannot be observed. In this sense, the "all-in-focus image," which holds the in-focused texture all over the image, is useful to observe the microenvironments on the microscope. It is also important to obtain the "depth map" which could show the 3D micro virtual environments in real-time to actuate the micro objects, intuitively. To realize the real-time micro operation with DFF criteria, which has to integrate several images to obtain "all-in-focus image" and "depth map," at least, the 240 frames par second based image capture and processing system should be required. At first, this paper briefly reviews the criteria of "depth from focus" to achieve the all-in-focus image and the 3D microenvironments' reconstruction, simultaneously. After discussing the problem in our past system, a new frame-rate system is constructed with the high-speed video camera and FPGA hardware with 240 frames par second. To apply this system in the real microscope, a new criterion "ghost filtering" technique to reconstruct the all-in-focus image is proposed. Finally, the micro observation shows the validity of this system.

A Study on the Effects of Alternatives to Speed Humps Using a Driving Simulator

NASA Astrophysics Data System (ADS)

Kim, Jong-Min; Noh, Kwan-Sub

A road alignment which has a long straight section followed by sharp curve is dangerous, because drivers have the habit to accelerate on the long straight section and then accidents occur on the short curve as the result of speeding. This study evaluated the alternatives to speed humps in order to reduce speed safely and comfortably on roads with this incorrect road alignment. There are several speed control facilities to reduce speed on roads with wrong road alignment. The speed hump is dangerous at high speeds because drivers must reduce speed rapidly and because of the physical impact. The image hump provides less effect for drivers who already know of its presence. So, to resolve these matters, we propose a new type of speed control facility. An image hump with transverse grooving will be effective in reducing speed because the transverse grooving gives vibration and noise to drivers who are already aware of the presence of the image hump, but it does not give the hard physical impact to vehicles. The study on the effect of the alternatives to speed humps was carried out using the K-ROADS (KICT-Road Analysis Driving Simulator) which has been developed to analyze and evaluate road safety at the project HuRoSAS (Human & Road Safety Analysis System) since 2003. K-ROADS has two distinct functions. One is the visual system which has a 360 degree F. O. V. to reduce dead angles on black spots such as at-grade intersections. The other is the motion system which has high frequency vibration to reproduce vibrations made in irregular road surfaces. This study found out that the image hump with transverse grooving is a safe speed control facility in order to reduce driving speed safely and comfortably on a straight section followed by a sharp curve, even if drivers are known the existence of image hump.

Pulsed photoacoustic flow imaging with a handheld system

NASA Astrophysics Data System (ADS)

van den Berg, Pim J.; Daoudi, Khalid; Steenbergen, Wiendelt

2016-02-01

Flow imaging is an important technique in a range of disease areas, but estimating low flow speeds, especially near the walls of blood vessels, remains challenging. Pulsed photoacoustic flow imaging can be an alternative since there is little signal contamination from background tissue with photoacoustic imaging. We propose flow imaging using a clinical photoacoustic system that is both handheld and portable. The system integrates a linear array with 7.5 MHz central frequency in combination with a high-repetition-rate diode laser to allow high-speed photoacoustic imaging-ideal for this application. This work shows the flow imaging performance of the system in vitro using microparticles. Both two-dimensional (2-D) flow images and quantitative flow velocities from 12 to 75 mm/s were obtained. In a transparent bulk medium, flow estimation showed standard errors of ˜7% the estimated speed; in the presence of tissue-realistic optical scattering, the error increased to 40% due to limited signal-to-noise ratio. In the future, photoacoustic flow imaging can potentially be performed in vivo using fluorophore-filled vesicles or with an improved setup on whole blood.

Embedded system of image storage based on fiber channel

NASA Astrophysics Data System (ADS)

Chen, Xiaodong; Su, Wanxin; Xing, Zhongbao; Wang, Hualong

2008-03-01

In domains of aerospace, aviation, aiming, and optic measure etc., the embedded system of imaging, processing and recording is absolutely necessary, which has small volume, high processing speed and high resolution. But the embedded storage technology becomes system bottleneck because of developing slowly. It is used to use RAID to promote storage speed, but it is unsuitable for the embedded system because of its big volume. Fiber channel (FC) technology offers a new method to develop the high-speed, portable storage system. In order to make storage subsystem meet the needs of high storage rate, make use of powerful Virtex-4 FPGA and high speed fiber channel, advance a project of embedded system of digital image storage based on Xilinx Fiber Channel Arbitrated Loop LogiCORE. This project utilizes Virtex- 4 RocketIO MGT transceivers to transmit the data serially, and connects many Fiber Channel hard drivers by using of Arbitrated Loop optionally. It can achieve 400MBps storage rate, breaks through the bottleneck of PCI interface, and has excellences of high-speed, real-time, portable and massive capacity.

Aircraft engine-mounted camera system for long wavelength infrared imaging of in-service thermal barrier coated turbine blades

NASA Astrophysics Data System (ADS)

Markham, James; Cosgrove, Joseph; Scire, James; Haldeman, Charles; Agoos, Ian

2014-12-01

This paper announces the implementation of a long wavelength infrared camera to obtain high-speed thermal images of an aircraft engine's in-service thermal barrier coated turbine blades. Long wavelength thermal images were captured of first-stage blades. The achieved temporal and spatial resolutions allowed for the identification of cooling-hole locations. The software and synchronization components of the system allowed for the selection of any blade on the turbine wheel, with tuning capability to image from leading edge to trailing edge. Its first application delivered calibrated thermal images as a function of turbine rotational speed at both steady state conditions and during engine transients. In advance of presenting these data for the purpose of understanding engine operation, this paper focuses on the components of the system, verification of high-speed synchronized operation, and the integration of the system with the commercial jet engine test bed.

Aircraft engine-mounted camera system for long wavelength infrared imaging of in-service thermal barrier coated turbine blades.

PubMed

Markham, James; Cosgrove, Joseph; Scire, James; Haldeman, Charles; Agoos, Ian

2014-12-01

This paper announces the implementation of a long wavelength infrared camera to obtain high-speed thermal images of an aircraft engine's in-service thermal barrier coated turbine blades. Long wavelength thermal images were captured of first-stage blades. The achieved temporal and spatial resolutions allowed for the identification of cooling-hole locations. The software and synchronization components of the system allowed for the selection of any blade on the turbine wheel, with tuning capability to image from leading edge to trailing edge. Its first application delivered calibrated thermal images as a function of turbine rotational speed at both steady state conditions and during engine transients. In advance of presenting these data for the purpose of understanding engine operation, this paper focuses on the components of the system, verification of high-speed synchronized operation, and the integration of the system with the commercial jet engine test bed.

Commercially available high-speed system for recording and monitoring vocal fold vibrations.

PubMed

Sekimoto, Sotaro; Tsunoda, Koichi; Kaga, Kimitaka; Makiyama, Kiyoshi; Tsunoda, Atsunobu; Kondo, Kenji; Yamasoba, Tatsuya

2009-12-01

We have developed a special purpose adaptor making it possible to use a commercially available high-speed camera to observe vocal fold vibrations during phonation. The camera can capture dynamic digital images at speeds of 600 or 1200 frames per second. The adaptor is equipped with a universal-type attachment and can be used with most endoscopes sold by various manufacturers. Satisfactory images can be obtained with a rigid laryngoscope even with the standard light source. The total weight of the adaptor and camera (including battery) is only 1010 g. The new system comprising the high-speed camera and the new adaptor can be purchased for about $3000 (US), while the least expensive stroboscope costs about 10 times that price, and a high-performance high-speed imaging system may cost 100 times as much. Therefore the system is both cost-effective and useful in the outpatient clinic or casualty setting, on house calls, and for the purpose of student or patient education.

Ultrahigh- and high-speed photography, videography, and photonics '91; Proceedings of the Meeting, San Diego, CA, July 24-26, 1991

NASA Astrophysics Data System (ADS)

Jaanimagi, Paul A.

1992-01-01

This volume presents papers grouped under the topics on advances in streak and framing camera technology, applications of ultrahigh-speed photography, characterizing high-speed instrumentation, high-speed electronic imaging technology and applications, new technology for high-speed photography, high-speed imaging and photonics in detonics, and high-speed velocimetry. The papers presented include those on a subpicosecond X-ray streak camera, photocathodes for ultrasoft X-ray region, streak tube dynamic range, high-speed TV cameras for streak tube readout, femtosecond light-in-flight holography, and electrooptical systems characterization techniques. Attention is also given to high-speed electronic memory video recording techniques, high-speed IR imaging of repetitive events using a standard RS-170 imager, use of a CCD array as a medium-speed streak camera, the photography of shock waves in explosive crystals, a single-frame camera based on the type LD-S-10 intensifier tube, and jitter diagnosis for pico- and femtosecond sources.

Extended depth of field imaging for high speed object analysis

NASA Technical Reports Server (NTRS)

Frost, Keith (Inventor); Ortyn, William (Inventor); Basiji, David (Inventor); Bauer, Richard (Inventor); Liang, Luchuan (Inventor); Hall, Brian (Inventor); Perry, David (Inventor)

2011-01-01

A high speed, high-resolution flow imaging system is modified to achieve extended depth of field imaging. An optical distortion element is introduced into the flow imaging system. Light from an object, such as a cell, is distorted by the distortion element, such that a point spread function (PSF) of the imaging system is invariant across an extended depth of field. The distorted light is spectrally dispersed, and the dispersed light is used to simultaneously generate a plurality of images. The images are detected, and image processing is used to enhance the detected images by compensating for the distortion, to achieve extended depth of field images of the object. The post image processing preferably involves de-convolution, and requires knowledge of the PSF of the imaging system, as modified by the optical distortion element.

Rapid and noncontact photoacoustic tomography imaging system using an interferometer with high-speed phase modulation technique

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Jun; Tang, Zhilie; Wu, Yongbo

2015-04-15

We designed, fabricated, and tested a rapid and noncontact photoacoustic tomography (PAT) imaging system using a low-coherence interferometer with high-speed phase modulation technique. Such a rapid and noncontact probing system can greatly decrease the time of imaging. The proposed PAT imaging system is experimentally verified by capturing images of a simulated tissue sample and the blood vessels within the ear flap of a mouse (pinna) in vivo. The axial and lateral resolutions of the system are evaluated at 45 and ∼15 μm, respectively. The imaging depth of the system is 1 mm in a special phantom. Our results show thatmore » the proposed system opens a promising way to realize noncontact, real-time PAT.« less

A machine vision system for high speed sorting of small spots on grains

USDA-ARS?s Scientific Manuscript database

A sorting system was developed to detect and remove individual grain kernels with small localized blemishes or defects. The system uses a color VGA sensor to capture images of the kernels at high speed as the grain drops off an inclined chute. The image data are directly input into a field-programma...

Nonlinear optical microscopy for immunoimaging: a custom optimized system of high-speed, large-area, multicolor imaging

PubMed Central

Li, Hui; Cui, Quan; Zhang, Zhihong; Luo, Qingming

2015-01-01

Background The nonlinear optical microscopy has become the current state-of-the-art for intravital imaging. Due to its advantages of high resolution, superior tissue penetration, lower photodamage and photobleaching, as well as intrinsic z-sectioning ability, this technology has been widely applied in immunoimaging for a decade. However, in terms of monitoring immune events in native physiological environment, the conventional nonlinear optical microscope system has to be optimized for live animal imaging. Generally speaking, three crucial capabilities are desired, including high-speed, large-area and multicolor imaging. Among numerous high-speed scanning mechanisms used in nonlinear optical imaging, polygon scanning is not only linearly but also dispersion-freely with high stability and tunable rotation speed, which can overcome disadvantages of multifocal scanning, resonant scanner and acousto-optical deflector (AOD). However, low frame rate, lacking large-area or multicolor imaging ability make current polygonbased nonlinear optical microscopes unable to meet the requirements of immune event monitoring. Methods We built up a polygon-based nonlinear optical microscope system which was custom optimized for immunoimaging with high-speed, large-are and multicolor imaging abilities. Results Firstly, we validated the imaging performance of the system by standard methods. Then, to demonstrate the ability to monitor immune events, migration of immunocytes observed by the system based on typical immunological models such as lymph node, footpad and dorsal skinfold chamber are shown. Finally, we take an outlook for the possible advance of related technologies such as sample stabilization and optical clearing for more stable and deeper intravital immunoimaging. Conclusions This study will be helpful for optimizing nonlinear optical microscope to obtain more comprehensive and accurate information of immune events. PMID:25694951

Overview of High Speed Close-Up Imaging in an Icing Environment

NASA Technical Reports Server (NTRS)

Miller, Dean R.; Lynch, Christopher J.; Tate, Peter A.

2004-01-01

The Icing Branch and Imaging Technology Center at NASA Glenn Research Center have recently been involved in several projects where high speed close-up imaging was used to investigate water droplet impact/splash, and also ice particle impact/bounce in an icing wind tunnel. The combination of close-up and high speed imaging capabilities were required because the particles being studied were relatively small (d < 1 mm in diameter), and the impact process occurred in a very short time period (t(sub impact) << 1 sec). High speed close-up imaging was utilized to study the dynamics of droplet impact and splash in simulated Supercooled Large Droplet (SLD) icing conditions. The objective of this test was to evaluate the capability of a ultra high speed camera system to acquire quantitative information about the impact process (e.g., droplet size, velocity). Imaging data were obtained in an icing wind tunnel for spray cloud MVD > 50 m. High speed close-up imaging was also utilized to characterize the impact of ice particles on an airfoil with a thermally protected leading edge. The objective of this investigation was to determine whether ice particles tend to "stick" or "bounce" after impact. Imaging data were obtained for cases where the airfoil surface was heated and unheated. Based on the results from this test, follow on tests were conducted to investigate ice particle impact on the sensing elements of water content measurement devices. This paper will describe the use of the imaging systems to support these experimental investigations, present some representative results, and summarize what was learned about the use of these systems in an icing environment.

A programmable computational image sensor for high-speed vision

NASA Astrophysics Data System (ADS)

Yang, Jie; Shi, Cong; Long, Xitian; Wu, Nanjian

2013-08-01

In this paper we present a programmable computational image sensor for high-speed vision. This computational image sensor contains four main blocks: an image pixel array, a massively parallel processing element (PE) array, a row processor (RP) array and a RISC core. The pixel-parallel PE is responsible for transferring, storing and processing image raw data in a SIMD fashion with its own programming language. The RPs are one dimensional array of simplified RISC cores, it can carry out complex arithmetic and logic operations. The PE array and RP array can finish great amount of computation with few instruction cycles and therefore satisfy the low- and middle-level high-speed image processing requirement. The RISC core controls the whole system operation and finishes some high-level image processing algorithms. We utilize a simplified AHB bus as the system bus to connect our major components. Programming language and corresponding tool chain for this computational image sensor are also developed.

SR high-speed K-edge subtraction angiography in the small animal (abstract)

NASA Astrophysics Data System (ADS)

Takeda, T.; Akisada, M.; Nakajima, T.; Anno, I.; Ueda, K.; Umetani, K.; Yamaguchi, C.

1989-07-01

To assess the ability of the high-speed K-edge energy subtraction system which was made at beamline 8C of Photon Factory, Tsukuba, we performed an animal experiment. Rabbits were used for the intravenous K-edge subtraction angiography. In this paper, the actual images of the artery obtained by this system, are demonstrated. The high-speed K-edge subtraction system consisted of movable silicon (111) monocrystals, II-ITV, and digital memory system. Image processing was performed by 68000-IP computer. The monochromatic x-ray beam size was 50×60 mm. Photon energy above and below iodine K edge was changed within 16 ms and 32 frames of images were obtained sequentially. The rabbits were anaesthetized by phenobarbital and a 5F catheter was inserted into inferior vena cava via the femoral vein. 1.5 ml/kg of contrast material (Conlaxin H) was injected at the rate of 0.5 ml/kg/s. TV images were obtained 3 s after the starting point of injection. By using this system, the clear K-edge subtracted images were obtained sequentially as a conventional DSA system. The quality of the images were better than that obtained by DSA. The dynamical blood flow was analyzed, and the best arterial image could be selected from the sequential images. The structures of aortic arch, common carotid arteries, right subclavian artery, and internal thoracic artery were obtained at the chest. Both common carotid arteries and vertebral arteries were recorded at the neck. The diameter of about 0.3-0.4 mm artery could be clearly revealed. The high-speed K-edge subtraction system demonstrates the very sharp arterial images clearly and dynamically.

A CMOS high speed imaging system design based on FPGA

NASA Astrophysics Data System (ADS)

Tang, Hong; Wang, Huawei; Cao, Jianzhong; Qiao, Mingrui

2015-10-01

CMOS sensors have more advantages than traditional CCD sensors. The imaging system based on CMOS has become a hot spot in research and development. In order to achieve the real-time data acquisition and high-speed transmission, we design a high-speed CMOS imaging system on account of FPGA. The core control chip of this system is XC6SL75T and we take advantages of CameraLink interface and AM41V4 CMOS image sensors to transmit and acquire image data. AM41V4 is a 4 Megapixel High speed 500 frames per second CMOS image sensor with global shutter and 4/3" optical format. The sensor uses column parallel A/D converters to digitize the images. The CameraLink interface adopts DS90CR287 and it can convert 28 bits of LVCMOS/LVTTL data into four LVDS data stream. The reflected light of objects is photographed by the CMOS detectors. CMOS sensors convert the light to electronic signals and then send them to FPGA. FPGA processes data it received and transmits them to upper computer which has acquisition cards through CameraLink interface configured as full models. Then PC will store, visualize and process images later. The structure and principle of the system are both explained in this paper and this paper introduces the hardware and software design of the system. FPGA introduces the driven clock of CMOS. The data in CMOS is converted to LVDS signals and then transmitted to the data acquisition cards. After simulation, the paper presents a row transfer timing sequence of CMOS. The system realized real-time image acquisition and external controls.

Real-time intravascular photoacoustic-ultrasound imaging of lipid-laden plaque at speed of video-rate level

NASA Astrophysics Data System (ADS)

Hui, Jie; Cao, Yingchun; Zhang, Yi; Kole, Ayeeshik; Wang, Pu; Yu, Guangli; Eakins, Gregory; Sturek, Michael; Chen, Weibiao; Cheng, Ji-Xin

2017-03-01

Intravascular photoacoustic-ultrasound (IVPA-US) imaging is an emerging hybrid modality for the detection of lipidladen plaques by providing simultaneous morphological and lipid-specific chemical information of an artery wall. The clinical utility of IVPA-US technology requires real-time imaging and display at speed of video-rate level. Here, we demonstrate a compact and portable IVPA-US system capable of imaging at up to 25 frames per second in real-time display mode. This unprecedented imaging speed was achieved by concurrent innovations in excitation laser source, rotary joint assembly, 1 mm IVPA-US catheter, differentiated A-line strategy, and real-time image processing and display algorithms. By imaging pulsatile motion at different imaging speeds, 16 frames per second was deemed to be adequate to suppress motion artifacts from cardiac pulsation for in vivo applications. Our lateral resolution results further verified the number of A-lines used for a cross-sectional IVPA image reconstruction. The translational capability of this system for the detection of lipid-laden plaques was validated by ex vivo imaging of an atherosclerotic human coronary artery at 16 frames per second, which showed strong correlation to gold-standard histopathology.

Performance comparison between the high-speed Yokogawa spinning disc confocal system and single-point scanning confocal systems.

PubMed

Wang, E; Babbey, C M; Dunn, K W

2005-05-01

Fluorescence microscopy of the dynamics of living cells presents a special challenge to a microscope imaging system, simultaneously requiring both high spatial resolution and high temporal resolution, but with illumination levels low enough to prevent fluorophore damage and cytotoxicity. We have compared the high-speed Yokogawa CSU10 spinning disc confocal system with several conventional single-point scanning confocal (SPSC) microscopes, using the relationship between image signal-to-noise ratio and fluorophore photobleaching as an index of system efficiency. These studies demonstrate that the efficiency of the CSU10 consistently exceeds that of the SPSC systems. The high efficiency of the CSU10 means that quality images can be collected with much lower levels of illumination; the CSU10 was capable of achieving the maximum signal-to-noise of an SPSC system at illumination levels that incur only at 1/15th of the rate of the photobleaching of the SPSC system. Although some of the relative efficiency of the CSU10 system may be attributed to the use of a CCD rather than a photomultiplier detector system, our analyses indicate that high-speed imaging with the SPSC system is limited by fluorescence saturation at the high levels of illumination frequently needed to collect images at high frame rates. The high speed, high efficiency and freedom from fluorescence saturation combine to make the CSU10 effective for extended imaging of living cells at rates capable of capturing the three-dimensional motion of endosomes moving up to several micrometres per second.

Magneto-optical system for high speed real time imaging.

PubMed

Baziljevich, M; Barness, D; Sinvani, M; Perel, E; Shaulov, A; Yeshurun, Y

2012-08-01

A new magneto-optical system has been developed to expand the range of high speed real time magneto-optical imaging. A special source for the external magnetic field has also been designed, using a pump solenoid to rapidly excite the field coil. Together with careful modifications of the cryostat, to reduce eddy currents, ramping rates reaching 3000 T/s have been achieved. Using a powerful laser as the light source, a custom designed optical assembly, and a high speed digital camera, real time imaging rates up to 30 000 frames per seconds have been demonstrated.

Magneto-optical system for high speed real time imaging

NASA Astrophysics Data System (ADS)

Baziljevich, M.; Barness, D.; Sinvani, M.; Perel, E.; Shaulov, A.; Yeshurun, Y.

2012-08-01

A new magneto-optical system has been developed to expand the range of high speed real time magneto-optical imaging. A special source for the external magnetic field has also been designed, using a pump solenoid to rapidly excite the field coil. Together with careful modifications of the cryostat, to reduce eddy currents, ramping rates reaching 3000 T/s have been achieved. Using a powerful laser as the light source, a custom designed optical assembly, and a high speed digital camera, real time imaging rates up to 30 000 frames per seconds have been demonstrated.

The Hurricane Imaging Radiometer: Present and Future

NASA Technical Reports Server (NTRS)

Miller, Timothy L.; James, M. W.; Roberts, J. B.; Biswas, S. K.; Cecil, D.; Jones, W. L.; Johnson, J.; Farrar, S.; Sahawneh, S.; Ruf, C. S.;

Perceived visual speed constrained by image segmentation

NASA Technical Reports Server (NTRS)

Verghese, P.; Stone, L. S.

1996-01-01

Little is known about how or where the visual system parses the visual scene into objects or surfaces. However, it is generally assumed that the segmentation and grouping of pieces of the image into discrete entities is due to 'later' processing stages, after the 'early' processing of the visual image by local mechanisms selective for attributes such as colour, orientation, depth, and motion. Speed perception is also thought to be mediated by early mechanisms tuned for speed. Here we show that manipulating the way in which an image is parsed changes the way in which local speed information is processed. Manipulations that cause multiple stimuli to appear as parts of a single patch degrade speed discrimination, whereas manipulations that perceptually divide a single large stimulus into parts improve discrimination. These results indicate that processes as early as speed perception may be constrained by the parsing of the visual image into discrete entities.

Motion-blur-compensated structural health monitoring system for tunnels at a speed of 100 km/h

NASA Astrophysics Data System (ADS)

Hayakawa, Tomohiko; Ishikawa, Masatoshi

2017-04-01

High quality images of tunnel surfaces are necessary for visual judgment of abnormal parts. Hence, we propose a monitoring system from a vehicle, which is motion-blur-compensated by the back and forth motion of a galvanometer mirror to offset the vehicle speed, prolong exposure time, and take sharp images including detailed textures. As experimental result of the vehicle-mounted system, we confirmed significant improvements in image quality for a few millimeter-sized ordered black-and-white stripes and cracks, by means of motion blur compensation and prolonged exposure time, under the maximum speed allowed in Japan in a standard tunnel of a highway.

Combined High-Speed 3D Scalar and Velocity Reconstruction of Hairpin Vortex

NASA Astrophysics Data System (ADS)

Sabatino, Daniel; Rossmann, Tobias; Zhu, Xuanyu; Thorsen, Mary

2017-11-01

The combination of 3D scanning stereoscopic particle image velocimetry (PIV) and 3D Planar Laser Induced Fluorescence (PLIF) is used to create high-speed three-dimensional reconstructions of the scalar and velocity fields of a developing hairpin vortex. The complete description of the regenerating hairpin vortex is needed as transitional boundary layers and turbulent spots are both comprised of and influenced by these vortices. A new high-speed, high power, laser-based imaging system is used which enables both high-speed 3D scanning stereo PIV and PLIF measurements. The experimental system uses a 250 Hz scanning mirror, two high-speed cameras with a 10 kHz frame rate, and a 40 kHz pulsed laser. Individual stereoscopic PIV images and scalar PLIF images are then reconstructed into time-resolved volumetric velocity and scalar data. The results from the volumetric velocity and scalar fields are compared to previous low-speed tomographic PIV data and scalar visualizations to determine the accuracy and fidelity of the high-speed diagnostics. Comparisons between the velocity and scalar field during hairpin development and regeneration are also discussed. Supported by the National Science Foundation under Grant CBET-1531475, Lafayette College,and the McCutcheon Foundation.

Acceleration of integral imaging based incoherent Fourier hologram capture using graphic processing unit.

PubMed

Jeong, Kyeong-Min; Kim, Hee-Seung; Hong, Sung-In; Lee, Sung-Keun; Jo, Na-Young; Kim, Yong-Soo; Lim, Hong-Gi; Park, Jae-Hyeung

2012-10-08

Speed enhancement of integral imaging based incoherent Fourier hologram capture using a graphic processing unit is reported. Integral imaging based method enables exact hologram capture of real-existing three-dimensional objects under regular incoherent illumination. In our implementation, we apply parallel computation scheme using the graphic processing unit, accelerating the processing speed. Using enhanced speed of hologram capture, we also implement a pseudo real-time hologram capture and optical reconstruction system. The overall operation speed is measured to be 1 frame per second.

FBI Fingerprint Image Capture System High-Speed-Front-End throughput modeling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rathke, P.M.

1993-09-01

The Federal Bureau of Investigation (FBI) has undertaken a major modernization effort called the Integrated Automated Fingerprint Identification System (IAFISS). This system will provide centralized identification services using automated fingerprint, subject descriptor, mugshot, and document processing. A high-speed Fingerprint Image Capture System (FICS) is under development as part of the IAFIS program. The FICS will capture digital and microfilm images of FBI fingerprint cards for input into a central database. One FICS design supports two front-end scanning subsystems, known as the High-Speed-Front-End (HSFE) and Low-Speed-Front-End, to supply image data to a common data processing subsystem. The production rate of themore » HSFE is critical to meeting the FBI`s fingerprint card processing schedule. A model of the HSFE has been developed to help identify the issues driving the production rate, assist in the development of component specifications, and guide the evolution of an operations plan. A description of the model development is given, the assumptions are presented, and some HSFE throughput analysis is performed.« less

In vitro comparison between the image obtained using PSP plates and Kodak E-speed films.

PubMed

Petel, R; Yaroslavsky, L; Kaffe, I

2014-07-01

The aim of this study was to compare the intra-oral radiographic images obtained by a PSP digital radiography system ("Orex", Israel) with that obtained using Kodak Ultra speed films in terms of image quality, radiation dosage and diagnostic value. The physical measurement of image quality was conducted with an aluminum step-wedge. Radiation dosage was measured with a dosimeter. Fog and base levels were measured by developing unexposed films and scanning unexposed PSP plates. The in vitro model included preparation and radiographic evaluation of approximal artificial lesions in premolars and molars in depths ranging from 0.25 mm to 1.00 mm. Radiographs were evaluated for the existence of a lesion and its size by 8 experienced clinicians. Relative contrast was similar in both methods. The resolving power of the digital system was lower than that of the E-speed film. As for the subjective evaluation of artificial lesions, there was no significant difference between the two methods excluding those tooth images without lesions, where the analog method was found to be more accurate. The PSP system ("Orex") provides good image quality and diagnostic information with reduced exposure when compared with E-speed film.

Real-time speckle variance swept-source optical coherence tomography using a graphics processing unit.

PubMed

Lee, Kenneth K C; Mariampillai, Adrian; Yu, Joe X Z; Cadotte, David W; Wilson, Brian C; Standish, Beau A; Yang, Victor X D

2012-07-01

Advances in swept source laser technology continues to increase the imaging speed of swept-source optical coherence tomography (SS-OCT) systems. These fast imaging speeds are ideal for microvascular detection schemes, such as speckle variance (SV), where interframe motion can cause severe imaging artifacts and loss of vascular contrast. However, full utilization of the laser scan speed has been hindered by the computationally intensive signal processing required by SS-OCT and SV calculations. Using a commercial graphics processing unit that has been optimized for parallel data processing, we report a complete high-speed SS-OCT platform capable of real-time data acquisition, processing, display, and saving at 108,000 lines per second. Subpixel image registration of structural images was performed in real-time prior to SV calculations in order to reduce decorrelation from stationary structures induced by the bulk tissue motion. The viability of the system was successfully demonstrated in a high bulk tissue motion scenario of human fingernail root imaging where SV images (512 × 512 pixels, n = 4) were displayed at 54 frames per second.

Design of a dataway processor for a parallel image signal processing system

NASA Astrophysics Data System (ADS)

Nomura, Mitsuru; Fujii, Tetsuro; Ono, Sadayasu

1995-04-01

Recently, demands for high-speed signal processing have been increasing especially in the field of image data compression, computer graphics, and medical imaging. To achieve sufficient power for real-time image processing, we have been developing parallel signal-processing systems. This paper describes a communication processor called 'dataway processor' designed for a new scalable parallel signal-processing system. The processor has six high-speed communication links (Dataways), a data-packet routing controller, a RISC CORE, and a DMA controller. Each communication link operates at 8-bit parallel in a full duplex mode at 50 MHz. Moreover, data routing, DMA, and CORE operations are processed in parallel. Therefore, sufficient throughput is available for high-speed digital video signals. The processor is designed in a top- down fashion using a CAD system called 'PARTHENON.' The hardware is fabricated using 0.5-micrometers CMOS technology, and its hardware is about 200 K gates.

High-speed real-time image compression based on all-optical discrete cosine transformation

NASA Astrophysics Data System (ADS)

Guo, Qiang; Chen, Hongwei; Wang, Yuxi; Chen, Minghua; Yang, Sigang; Xie, Shizhong

2017-02-01

In this paper, we present a high-speed single-pixel imaging (SPI) system based on all-optical discrete cosine transform (DCT) and demonstrate its capability to enable noninvasive imaging of flowing cells in a microfluidic channel. Through spectral shaping based on photonic time stretch (PTS) and wavelength-to-space conversion, structured illumination patterns are generated at a rate (tens of MHz) which is three orders of magnitude higher than the switching rate of a digital micromirror device (DMD) used in a conventional single-pixel camera. Using this pattern projector, high-speed image compression based on DCT can be achieved in the optical domain. In our proposed system, a high compression ratio (approximately 10:1) and a fast image reconstruction procedure are both achieved, which implicates broad applications in industrial quality control and biomedical imaging.

SPED light sheet microscopy: fast mapping of biological system structure and function

PubMed Central

Tomer, Raju; Lovett-Barron, Matthew; Kauvar, Isaac; Andalman, Aaron; Burns, Vanessa M.; Sankaran, Sethuraman; Grosenick, Logan; Broxton, Michael; Yang, Samuel; Deisseroth, Karl

2016-01-01

The goal of understanding living nervous systems has driven interest in high-speed and large field-of-view volumetric imaging at cellular resolution. Light-sheet microscopy approaches have emerged for cellular-resolution functional brain imaging in small organisms such as larval zebrafish, but remain fundamentally limited in speed. Here we have developed SPED light sheet microscopy, which combines large volumetric field-of-view via an extended depth of field with the optical sectioning of light sheet microscopy, thereby eliminating the need to physically scan detection objectives for volumetric imaging. SPED enables scanning of thousands of volumes-per-second, limited only by camera acquisition rate, through the harnessing of optical mechanisms that normally result in unwanted spherical aberrations. We demonstrate capabilities of SPED microscopy by performing fast sub-cellular resolution imaging of CLARITY mouse brains and cellular-resolution volumetric Ca2+ imaging of entire zebrafish nervous systems. Together, SPED light sheet methods enable high-speed cellular-resolution volumetric mapping of biological system structure and function. PMID:26687363

On-demand server-side image processing for web-based DICOM image display

NASA Astrophysics Data System (ADS)

Sakusabe, Takaya; Kimura, Michio; Onogi, Yuzo

2000-04-01

Low cost image delivery is needed in modern networked hospitals. If a hospital has hundreds of clients, cost of client systems is a big problem. Naturally, a Web-based system is the most effective solution. But a Web browser could not display medical images with certain image processing such as a lookup table transformation. We developed a Web-based medical image display system using Web browser and on-demand server-side image processing. All images displayed on a Web page are generated from DICOM files on a server, delivered on-demand. User interaction on the Web page is handled by a client-side scripting technology such as JavaScript. This combination makes a look-and-feel of an imaging workstation not only for its functionality but also for its speed. Real time update of images with tracing mouse motion is achieved on Web browser without any client-side image processing which may be done by client-side plug-in technology such as Java Applets or ActiveX. We tested performance of the system in three cases. Single client, small number of clients in a fast speed network, and large number of clients in a normal speed network. The result shows that there are very slight overhead for communication and very scalable in number of clients.

High speed intravascular photoacoustic imaging of atherosclerotic arteries (Conference Presentation)

NASA Astrophysics Data System (ADS)

Piao, Zhonglie; Ma, Teng; Qu, Yueqiao; Li, Jiawen; Yu, Mingyue; He, Youmin; Shung, K. Kirk; Zhou, Qifa; Kim, Chang-Seok; Chen, Zhongping

2016-02-01

Cardiovascular disease is the leading cause of death in the industrialized nations. Accurate quantification of both the morphology and composition of lipid-rich vulnerable atherosclerotic plaque are essential for early detection and optimal treatment in clinics. In previous works, intravascular photoacoustic (IVPA) imaging for detection of lipid-rich plaque within coronary artery walls has been demonstrated in ex vivo, but the imaging speed is still limited. In order to increase the imaging speed, a high repetition rate laser is needed. In this work, we present a high speed integrated IVPA/US imaging system with a 500 Hz optical parametric oscillator laser at 1725 nm. A miniature catheter with 1.0 mm outer diameter was designed with a 200 μm multimode fiber and an ultrasound transducer with 45 MHz center frequency. The fiber was polished at 38 degree and enclosed in a glass capillary for total internal reflection. An optical/electrical rotary junction and pull-back mechanism was applied for rotating and linearly scanning the catheter to obtain three-dimensional imaging. Atherosclerotic rabbit abdominal aorta was imaged as two frame/second at 1725 nm. Furthermore, by wide tuning range of the laser wavelength from 1680 nm to 1770 nm, spectroscopic photoacoustic analysis of lipid-mimicking phantom and an human atherosclerotic artery was performed ex vivo. The results demonstrated that the developed IVPA/US imaging system is capable for high speed intravascular imaging for plaque detection.

Ultrahigh-speed ultrahigh-resolution adaptive optics: optical coherence tomography system for in-vivo small animal retinal imaging

NASA Astrophysics Data System (ADS)

Jian, Yifan; Xu, Jing; Zawadzki, Robert J.; Sarunic, Marinko V.

2013-03-01

Small animal models of human retinal diseases are a critical component of vision research. In this report, we present an ultrahigh-resolution ultrahigh-speed adaptive optics optical coherence tomography (AO-OCT) system for small animal retinal imaging (mouse, fish, etc.). We adapted our imaging system to different types of small animals in accordance with the optical properties of their eyes. Results of AO-OCT images of small animal retinas acquired with AO correction are presented. Cellular structures including nerve fiber bundles, capillary networks and detailed double-cone photoreceptors are visualized.

Development of two-framing camera with large format and ultrahigh speed

NASA Astrophysics Data System (ADS)

Jiang, Xiaoguo; Wang, Yuan; Wang, Yi

2012-10-01

High-speed imaging facility is important and necessary for the formation of time-resolved measurement system with multi-framing capability. The framing camera which satisfies the demands of both high speed and large format needs to be specially developed in the ultrahigh speed research field. A two-framing camera system with high sensitivity and time-resolution has been developed and used for the diagnosis of electron beam parameters of Dragon-I linear induction accelerator (LIA). The camera system, which adopts the principle of light beam splitting in the image space behind the lens with long focus length, mainly consists of lens-coupled gated image intensifier, CCD camera and high-speed shutter trigger device based on the programmable integrated circuit. The fastest gating time is about 3 ns, and the interval time between the two frames can be adjusted discretely at the step of 0.5 ns. Both the gating time and the interval time can be tuned to the maximum value of about 1 s independently. Two images with the size of 1024×1024 for each can be captured simultaneously in our developed camera. Besides, this camera system possesses a good linearity, uniform spatial response and an equivalent background illumination as low as 5 electrons/pix/sec, which fully meets the measurement requirements of Dragon-I LIA.

Onboard Image Processing System for Hyperspectral Sensor

PubMed Central

Hihara, Hiroki; Moritani, Kotaro; Inoue, Masao; Hoshi, Yoshihiro; Iwasaki, Akira; Takada, Jun; Inada, Hitomi; Suzuki, Makoto; Seki, Taeko; Ichikawa, Satoshi; Tanii, Jun

2015-01-01

Onboard image processing systems for a hyperspectral sensor have been developed in order to maximize image data transmission efficiency for large volume and high speed data downlink capacity. Since more than 100 channels are required for hyperspectral sensors on Earth observation satellites, fast and small-footprint lossless image compression capability is essential for reducing the size and weight of a sensor system. A fast lossless image compression algorithm has been developed, and is implemented in the onboard correction circuitry of sensitivity and linearity of Complementary Metal Oxide Semiconductor (CMOS) sensors in order to maximize the compression ratio. The employed image compression method is based on Fast, Efficient, Lossless Image compression System (FELICS), which is a hierarchical predictive coding method with resolution scaling. To improve FELICS’s performance of image decorrelation and entropy coding, we apply a two-dimensional interpolation prediction and adaptive Golomb-Rice coding. It supports progressive decompression using resolution scaling while still maintaining superior performance measured as speed and complexity. Coding efficiency and compression speed enlarge the effective capacity of signal transmission channels, which lead to reducing onboard hardware by multiplexing sensor signals into a reduced number of compression circuits. The circuitry is embedded into the data formatter of the sensor system without adding size, weight, power consumption, and fabrication cost. PMID:26404281

Correction of rotational distortion for catheter-based en face OCT and OCT angiography

PubMed Central

Ahsen, Osman O.; Lee, Hsiang-Chieh; Giacomelli, Michael G.; Wang, Zhao; Liang, Kaicheng; Tsai, Tsung-Han; Potsaid, Benjamin; Mashimo, Hiroshi; Fujimoto, James G.

2015-01-01

We demonstrate a computationally efficient method for correcting the nonuniform rotational distortion (NURD) in catheter-based imaging systems to improve endoscopic en face optical coherence tomography (OCT) and OCT angiography. The method performs nonrigid registration using fiducial markers on the catheter to correct rotational speed variations. Algorithm performance is investigated with an ultrahigh-speed endoscopic OCT system and micromotor catheter. Scan nonuniformity is quantitatively characterized, and artifacts from rotational speed variations are significantly reduced. Furthermore, we present endoscopic en face OCT and OCT angiography images of human gastrointestinal tract in vivo to demonstrate the image quality improvement using the correction algorithm. PMID:25361133

High speed color imaging through scattering media with a large field of view

NASA Astrophysics Data System (ADS)

Zhuang, Huichang; He, Hexiang; Xie, Xiangsheng; Zhou, Jianying

2016-09-01

Optical imaging through complex media has many important applications. Although research progresses have been made to recover optical image through various turbid media, the widespread application of the technology is hampered by the recovery speed, requirement on specific illumination, poor image quality and limited field of view. Here we demonstrate that above-mentioned drawbacks can be essentially overcome. The realization of high speed color imaging through turbid media is successfully carried out by taking into account the media memory effect, the point spread function, the exit pupil of the optical system, and the optimized signal to noise ratio. By retrieving selected speckles with enlarged field of view, high quality image is recovered with a responding speed only determined by the frame rates of the image capturing devices. The immediate application of the technique is expected to register static and dynamic imaging under human skin to recover information with a wearable device.

Design and realization of an AEC&AGC system for the CCD aerial camera

NASA Astrophysics Data System (ADS)

Liu, Hai ying; Feng, Bing; Wang, Peng; Li, Yan; Wei, Hao yun

2015-08-01

An AEC and AGC(Automatic Exposure Control and Automatic Gain Control) system was designed for a CCD aerial camera with fixed aperture and electronic shutter. The normal AEC and AGE algorithm is not suitable to the aerial camera since the camera always takes high-resolution photographs in high-speed moving. The AEC and AGE system adjusts electronic shutter and camera gain automatically according to the target brightness and the moving speed of the aircraft. An automatic Gamma correction is used before the image is output so that the image is better for watching and analyzing by human eyes. The AEC and AGC system could avoid underexposure, overexposure, or image blurring caused by fast moving or environment vibration. A series of tests proved that the system meet the requirements of the camera system with its fast adjusting speed, high adaptability, high reliability in severe complex environment.

Evaluating the four-dimensional cone beam computed tomography with varying gantry rotation speed

PubMed Central

Maria Das, K J; Mohamed Ali, Shajahan; Agarwal, Arpita; Mishra, Surendra P; Kumar, Shaleen

2016-01-01

Objective: The purpose of this work was to evaluate the four-dimensional cone beam CT (4DCBCT) imaging with different gantry rotation speed. Methods: All the 4DCBCT image acquisitions were carried out in Elekta XVI Symmetry™ system (Elekta AB, Stockholm, Sweden). A dynamic thorax phantom with tumour mimicking inserts of diameter 1, 2 and 3 cm was programmed to simulate the respiratory motion (4 s) of the target. 4DCBCT images were acquired with different gantry rotation speeds (36°, 50°, 75°, 100°, 150° and 200° min−1). Owing to the technical limitation of 4DCBCT system, average cone beam CT (CBCT) images derived from the 10 phases of 4DCBCT were used for the internal target volume (ITV) contouring. ITVs obtained from average CBCT were compared with the four-dimensional CT (4DCT). In addition, the image quality of 4DCBCT was also evaluated for various gantry rotation speeds using Catphan® 600 (The Phantom Laboratory Inc., Salem, NY). Results: Compared to 4DCT, the average CBCT underestimated the ITV. The ITV deviation increased with increasing gantry speed (−10.8% vs −17.8% for 36° and 200° min−1 in 3-cm target) and decreasing target size (−17.8% vs −26.8% for target diameter 3 and 1 cm in 200° min−1). Similarly, the image quality indicators such as spatial resolution, contrast-to-noise ratio and uniformity also degraded with increasing gantry rotation speed. Conclusion: The impact of gantry rotation speed has to be considered when using 4DCBCT for ITV definition. The phantom study demonstrated that 4DCBCT with slow gantry rotation showed better image quality and less ITV deviation. Advances in knowledge: Usually, the gantry rotation period of Elekta 4DCBCT system is kept constant at 4 min (50° min−1) for acquisition, and any attempt of decreasing/increasing the acquisition duration requires careful investigation. In this study, the 4DCBCT images with different gantry rotation speed were evaluated. PMID:26916281

Applied high-speed imaging for the icing research program at NASA Lewis Research Center

NASA Technical Reports Server (NTRS)

Slater, Howard; Owens, Jay; Shin, Jaiwon

1992-01-01

The Icing Research Tunnel at NASA Lewis Research Center provides scientists a scaled, controlled environment to simulate natural icing events. The closed-loop, low speed, refrigerated wind tunnel offers the experimental capability to test for icing certification requirements, analytical model validation and calibration techniques, cloud physics instrumentation refinement, advanced ice protection systems, and rotorcraft icing methodology development. The test procedures for these objectives all require a high degree of visual documentation, both in real-time data acquisition and post-test image processing. Information is provided to scientific, technical, and industrial imaging specialists as well as to research personnel about the high-speed and conventional imaging systems will be on the recent ice protection technology program. Various imaging examples for some of the tests are presented. Additional imaging examples are available from the NASA Lewis Research Center's Photographic and Printing Branch.

Applied high-speed imaging for the icing research program at NASA Lewis Research Center

NASA Technical Reports Server (NTRS)

Slater, Howard; Owens, Jay; Shin, Jaiwon

1991-01-01

The Icing Research Tunnel at NASA Lewis Research Center provides scientists a scaled, controlled environment to simulate natural icing events. The closed-loop, low speed, refrigerated wind tunnel offers the experimental capability to test for icing certification requirements, analytical model validation and calibration techniques, cloud physics instrumentation refinement, advanced ice protection systems, and rotorcraft icing methodology development. The test procedures for these objectives all require a high degree of visual documentation, both in real-time data acquisition and post-test image processing. Information is provided to scientific, technical, and industrial imaging specialists as well as to research personnel about the high-speed and conventional imaging systems will be on the recent ice protection technology program. Various imaging examples for some of the tests are presented. Additional imaging examples are available from the NASA Lewis Research Center's Photographic and Printing Branch.

Brandaris 128 ultra-high-speed imaging facility: 10 years of operation, updates, and enhanced features

NASA Astrophysics Data System (ADS)

Gelderblom, Erik C.; Vos, Hendrik J.; Mastik, Frits; Faez, Telli; Luan, Ying; Kokhuis, Tom J. A.; van der Steen, Antonius F. W.; Lohse, Detlef; de Jong, Nico; Versluis, Michel

2012-10-01

The Brandaris 128 ultra-high-speed imaging facility has been updated over the last 10 years through modifications made to the camera's hardware and software. At its introduction the camera was able to record 6 sequences of 128 images (500 × 292 pixels) at a maximum frame rate of 25 Mfps. The segmented mode of the camera was revised to allow for subdivision of the 128 image sensors into arbitrary segments (1-128) with an inter-segment time of 17 μs. Furthermore, a region of interest can be selected to increase the number of recordings within a single run of the camera from 6 up to 125. By extending the imaging system with a laser-induced fluorescence setup, time-resolved ultra-high-speed fluorescence imaging of microscopic objects has been enabled. Minor updates to the system are also reported here.

Design and analysis of x-ray vision systems for high-speed detection of foreign body contamination in food

NASA Astrophysics Data System (ADS)

Graves, Mark; Smith, Alexander; Batchelor, Bruce G.; Palmer, Stephen C.

1994-10-01

In the food industry there is an ever increasing need to control and monitor food quality. In recent years fully automated x-ray inspection systems have been used to detect food on-line for foreign body contamination. These systems involve a complex integration of x- ray imaging components with state of the art high speed image processing. The quality of the x-ray image obtained by such systems is very poor compared with images obtained from other inspection processes, this makes reliable detection of very small, low contrast defects extremely difficult. It is therefore extremely important to optimize the x-ray imaging components to give the very best image possible. In this paper we present a method of analyzing the x-ray imaging system in order to consider the contrast obtained when viewing small defects.

Real-time clinically oriented array-based in vivo combined photoacoustic and power Doppler imaging

NASA Astrophysics Data System (ADS)

Harrison, Tyler; Jeffery, Dean; Wiebe, Edward; Zemp, Roger J.

2014-03-01

Photoacoustic imaging has great potential for identifying vascular regions for clinical imaging. In addition to assessing angiogenesis in cancers, there are many other disease processes that result in increased vascularity that present novel targets for photoacoustic imaging. Doppler imaging can provide good localization of large vessels, but poor imaging of small or low flow speed vessels and is susceptible to motion artifacts. Photoacoustic imaging can provide visualization of small vessels, but due to the filtering effects of ultrasound transducers, only shows the edges of large vessels. Thus, we have combined photoacoustic imaging with ultrasound power Doppler to provide contrast agent- free vascular imaging. We use a research-oriented ultrasound array system to provide interlaced ultrasound, Doppler, and photoacoustic imaging. This system features realtime display of all three modalities with adjustable persistence, rejection, and compression. For ease of use in a clinical setting, display of each mode can be disabled. We verify the ability of this system to identify vessels with varying flow speeds using receiver operating characteristic curves, and find that as flow speed falls, photoacoustic imaging becomes a much better method for identifying blood vessels. We also present several in vivo images of the thyroid and several synovial joints to assess the practicality of this imaging for clinical applications.

A computational approach to real-time image processing for serial time-encoded amplified microscopy

NASA Astrophysics Data System (ADS)

Oikawa, Minoru; Hiyama, Daisuke; Hirayama, Ryuji; Hasegawa, Satoki; Endo, Yutaka; Sugie, Takahisa; Tsumura, Norimichi; Kuroshima, Mai; Maki, Masanori; Okada, Genki; Lei, Cheng; Ozeki, Yasuyuki; Goda, Keisuke; Shimobaba, Tomoyoshi

2016-03-01

High-speed imaging is an indispensable technique, particularly for identifying or analyzing fast-moving objects. The serial time-encoded amplified microscopy (STEAM) technique was proposed to enable us to capture images with a frame rate 1,000 times faster than using conventional methods such as CCD (charge-coupled device) cameras. The application of this high-speed STEAM imaging technique to a real-time system, such as flow cytometry for a cell-sorting system, requires successively processing a large number of captured images with high throughput in real time. We are now developing a high-speed flow cytometer system including a STEAM camera. In this paper, we describe our approach to processing these large amounts of image data in real time. We use an analog-to-digital converter that has up to 7.0G samples/s and 8-bit resolution for capturing the output voltage signal that involves grayscale images from the STEAM camera. Therefore the direct data output from the STEAM camera generates 7.0G byte/s continuously. We provided a field-programmable gate array (FPGA) device as a digital signal pre-processor for image reconstruction and finding objects in a microfluidic channel with high data rates in real time. We also utilized graphics processing unit (GPU) devices for accelerating the calculation speed of identification of the reconstructed images. We built our prototype system, which including a STEAM camera, a FPGA device and a GPU device, and evaluated its performance in real-time identification of small particles (beads), as virtual biological cells, owing through a microfluidic channel.

Micro-optical system based 3D imaging for full HD depth image capturing

NASA Astrophysics Data System (ADS)

Park, Yong-Hwa; Cho, Yong-Chul; You, Jang-Woo; Park, Chang-Young; Yoon, Heesun; Lee, Sang-Hun; Kwon, Jong-Oh; Lee, Seung-Wan

2012-03-01

20 Mega-Hertz-switching high speed image shutter device for 3D image capturing and its application to system prototype are presented. For 3D image capturing, the system utilizes Time-of-Flight (TOF) principle by means of 20MHz high-speed micro-optical image modulator, so called 'optical shutter'. The high speed image modulation is obtained using the electro-optic operation of the multi-layer stacked structure having diffractive mirrors and optical resonance cavity which maximizes the magnitude of optical modulation. The optical shutter device is specially designed and fabricated realizing low resistance-capacitance cell structures having small RC-time constant. The optical shutter is positioned in front of a standard high resolution CMOS image sensor and modulates the IR image reflected from the object to capture a depth image. Suggested novel optical shutter device enables capturing of a full HD depth image with depth accuracy of mm-scale, which is the largest depth image resolution among the-state-of-the-arts, which have been limited up to VGA. The 3D camera prototype realizes color/depth concurrent sensing optical architecture to capture 14Mp color and full HD depth images, simultaneously. The resulting high definition color/depth image and its capturing device have crucial impact on 3D business eco-system in IT industry especially as 3D image sensing means in the fields of 3D camera, gesture recognition, user interface, and 3D display. This paper presents MEMS-based optical shutter design, fabrication, characterization, 3D camera system prototype and image test results.

High-speed reconstruction of compressed images

NASA Astrophysics Data System (ADS)

Cox, Jerome R., Jr.; Moore, Stephen M.

1990-07-01

A compression scheme is described that allows high-definition radiological images with greater than 8-bit intensity resolution to be represented by 8-bit pixels. Reconstruction of the images with their original intensity resolution can be carried out by means of a pipeline architecture suitable for compact, high-speed implementation. A reconstruction system is described that can be fabricated according to this approach and placed between an 8-bit display buffer and the display's video system thereby allowing contrast control of images at video rates. Results for 50 CR chest images are described showing that error-free reconstruction of the original 10-bit CR images can be achieved.

Full-field high-speed laser Doppler imaging system for blood-flow measurements

NASA Astrophysics Data System (ADS)

Serov, Alexandre; Lasser, Theo

2006-02-01

We describe the design and performance of a new full-field high-speed laser Doppler imaging system developed for mapping and monitoring of blood flow in biological tissue. The total imaging time for 256x256 pixels region of interest is 1.2 seconds. An integrating CMOS image sensor is utilized to detect Doppler signal in a plurality of points simultaneously on the sample illuminated by a divergent laser beam of a uniform intensity profile. The integrating property of the detector improves the signal-to-noise ratio of the measurement, which results in high-quality flow-images provided by the system. The new technique is real-time, non-invasive and the instrument is easy to use. The wide range of applications is one of the major challenges for a future application of the imager. High-resolution high-speed laser Doppler perfusion imaging is a promising optical technique for diagnostic and assessing the treatment effect of the diseases such as e.g. atherosclerosis, psoriasis, diabetes, skin cancer, allergies, peripheral vascular diseases, skin irritancy and wound healing. We present some biological applications of the new imager and discuss the perspectives for the future implementations of the imager for clinical and physiological applications.

An Ultra-High Speed Whole Slide Image Viewing System

PubMed Central

Yagi, Yukako; Yoshioka, Shigeatsu; Kyusojin, Hiroshi; Onozato, Maristela; Mizutani, Yoichi; Osato, Kiyoshi; Yada, Hiroaki; Mark, Eugene J.; Frosch, Matthew P.; Louis, David N.

2012-01-01

Background: One of the goals for a Whole Slide Imaging (WSI) system is implementation in the clinical practice of pathology. One of the unresolved problems in accomplishing this goal is the speed of the entire process, i.e., from viewing the slides through making the final diagnosis. Most users are not satisfied with the correct viewing speeds of available systems. We have evaluated a new WSI viewing station and tool that focuses on speed. Method: A prototype WSI viewer based on PlayStation®3 with wireless controllers was evaluated at the Department of Pathology at MGH for the following reasons: 1. For the simulation of signing-out cases; 2. Enabling discussion at a consensus conference; and 3. Use at slide seminars during a Continuing Medical Education course. Results: Pathologists were being able to use the system comfortably after 0–15 min training. There were no complaints regarding speed. Most pathologists were satisfied with the functionality, usability and speed of the system. The most difficult situation was simulating diagnostic sign-out. Conclusion: The preliminary results of adapting the Sony PlayStation®3 (PS3®) as an ultra-high speed WSI viewing system were promising. The achieved speed is consistent with what would be needed to use WSI in daily practice. PMID:22063731

An ultra-high speed Whole Slide Image viewing system.

PubMed

Yagi, Yukako; Yoshioka, Shigeatsu; Kyusojin, Hiroshi; Onozato, Maristela; Mizutani, Yoichi; Osato, Kiyoshi; Yada, Hiroaki; Mark, Eugene J; Frosch, Matthew P; Louis, David N

2012-01-01

One of the goals for a Whole Slide Imaging (WSI) system is implementation in the clinical practice of pathology. One of the unresolved problems in accomplishing this goal is the speed of the entire process, i.e., from viewing the slides through making the final diagnosis. Most users are not satisfied with the correct viewing speeds of available systems. We have evaluated a new WSI viewing station and tool that focuses on speed. A prototype WSI viewer based on PlayStation®3 with wireless controllers was evaluated at the Department of Pathology at MGH for the following reasons: 1. For the simulation of signing-out cases; 2. Enabling discussion at a consensus conference; and 3. Use at slide seminars during a Continuing Medical Education course. Pathologists were being able to use the system comfortably after 0-15 min training. There were no complaints regarding speed. Most pathologists were satisfied with the functionality, usability and speed of the system. The most difficult situation was simulating diagnostic sign-out. The preliminary results of adapting the Sony PlayStation®3 (PS3®) as an ultra-high speed WSI viewing system were promising. The achieved speed is consistent with what would be needed to use WSI in daily practice.

An ultra-high speed whole slide image viewing system.

PubMed

Yagi, Yukako; Yoshioka, Shigeatsu; Kyusojin, Hiroshi; Onozato, Maristela; Mizutani, Yoichi; Osato, Kiyoshi; Yada, Hiroaki; Mark, Eugene J; Frosch, Matthew P; Louis, David N

2012-01-01

One of the goals for a Whole Slide Imaging (WSI) system is implementation in the clinical practice of pathology. One of the unresolved problems in accomplishing this goal is the speed of the entire process, i.e., from viewing the slides through making the final diagnosis. Most users are not satisfied with the correct viewing speeds of available systems. We have evaluated a new WSI viewing station and tool that focuses on speed. A prototype WSI viewer based on PlayStation®3 with wireless controllers was evaluated at the Department of Pathology at MGH for the following reasons: 1. For the simulation of signing-out cases; 2. Enabling discussion at a consensus conference; and 3. Use at slide seminars during a Continuing Medical Education course. Pathologists were being able to use the system comfortably after 0-15 min training. There were no complaints regarding speed. Most pathologists were satisfied with the functionality, usability and speed of the system. The most difficult situation was simulating diagnostic sign-out. The preliminary results of adapting the Sony PlayStation®3 (PS3®) as an ultra-high speed WSI viewing system were promising. The achieved speed is consistent with what would be needed to use WSI in daily practice.

Hologram generation by horizontal scanning of a high-speed spatial light modulator.

PubMed

Takaki, Yasuhiro; Okada, Naoya

2009-06-10

In order to increase the image size and the viewing zone angle of a hologram, a high-speed spatial light modulator (SLM) is imaged as a vertically long image by an anamorphic imaging system, and this image is scanned horizontally by a galvano scanner. The reduction in horizontal pixel pitch of the SLM provides a wide viewing zone angle. The increased image height and horizontal scanning increased the image size. We demonstrated the generation of a hologram having a 15 degrees horizontal viewing zone angle and an image size of 3.4 inches with a frame rate of 60 Hz using a digital micromirror device with a frame rate of 13.333 kHz as a high-speed SLM.

Evaluation of alignment error due to a speed artifact in stereotactic ultrasound image guidance.

PubMed

Salter, Bill J; Wang, Brian; Szegedi, Martin W; Rassiah-Szegedi, Prema; Shrieve, Dennis C; Cheng, Roger; Fuss, Martin

2008-12-07

Ultrasound (US) image guidance systems used in radiotherapy are typically calibrated for soft tissue applications, thus introducing errors in depth-from-transducer representation when used in media with a different speed of sound propagation (e.g. fat). This error is commonly referred to as the speed artifact. In this study we utilized a standard US phantom to demonstrate the existence of the speed artifact when using a commercial US image guidance system to image through layers of simulated body fat, and we compared the results with calculated/predicted values. A general purpose US phantom (speed of sound (SOS) = 1540 m s(-1)) was imaged on a multi-slice CT scanner at a 0.625 mm slice thickness and 0.5 mm x 0.5 mm axial pixel size. Target-simulating wires inside the phantom were contoured and later transferred to the US guidance system. Layers of various thickness (1-8 cm) of commercially manufactured fat-simulating material (SOS = 1435 m s(-1)) were placed on top of the phantom to study the depth-related alignment error. In order to demonstrate that the speed artifact is not caused by adding additional layers on top of the phantom, we repeated these measurements in an identical setup using commercially manufactured tissue-simulating material (SOS = 1540 m s(-1)) for the top layers. For the fat-simulating material used in this study, we observed the magnitude of the depth-related alignment errors resulting from the speed artifact to be 0.7 mm cm(-1) of fat imaged through. The measured alignment errors caused by the speed artifact agreed with the calculated values within one standard deviation for all of the different thicknesses of fat-simulating material studied here. We demonstrated the depth-related alignment error due to the speed artifact when using US image guidance for radiation treatment alignment and note that the presence of fat causes the target to be aliased to a depth greater than it actually is. For typical US guidance systems in use today, this will lead to delivery of the high dose region at a position slightly posterior to the intended region for a supine patient. When possible, care should be taken to avoid imaging through a thick layer of fat for larger patients in US alignments or, if unavoidable, the spatial inaccuracies introduced by the artifact should be considered by the physician during the formulation of the treatment plan.

DMD-based quantitative phase microscopy and optical diffraction tomography

NASA Astrophysics Data System (ADS)

Zhou, Renjie

2018-02-01

Digital micromirror devices (DMDs), which offer high speed and high degree of freedoms in steering light illuminations, have been increasingly applied to optical microscopy systems in recent years. Lately, we introduced DMDs into digital holography to enable new imaging modalities and break existing imaging limitations. In this paper, we will first present our progress in using DMDs for demonstrating laser-illumination Fourier ptychographic microscopy (FPM) with shotnoise limited detection. After that, we will present a novel common-path quantitative phase microscopy (QPM) system based on using a DMD. Building on those early developments, a DMD-based high speed optical diffraction tomography (ODT) system has been recently demonstrated, and the results will also be presented. This ODT system is able to achieve video-rate 3D refractive-index imaging, which can potentially enable observations of high-speed 3D sample structural changes.

Imaging system design and image interpolation based on CMOS image sensor

NASA Astrophysics Data System (ADS)

Li, Yu-feng; Liang, Fei; Guo, Rui

2009-11-01

An image acquisition system is introduced, which consists of a color CMOS image sensor (OV9620), SRAM (CY62148), CPLD (EPM7128AE) and DSP (TMS320VC5509A). The CPLD implements the logic and timing control to the system. SRAM stores the image data, and DSP controls the image acquisition system through the SCCB (Omni Vision Serial Camera Control Bus). The timing sequence of the CMOS image sensor OV9620 is analyzed. The imaging part and the high speed image data memory unit are designed. The hardware and software design of the image acquisition and processing system is given. CMOS digital cameras use color filter arrays to sample different spectral components, such as red, green, and blue. At the location of each pixel only one color sample is taken, and the other colors must be interpolated from neighboring samples. We use the edge-oriented adaptive interpolation algorithm for the edge pixels and bilinear interpolation algorithm for the non-edge pixels to improve the visual quality of the interpolated images. This method can get high processing speed, decrease the computational complexity, and effectively preserve the image edges.

The Application of Virtex-II Pro FPGA in High-Speed Image Processing Technology of Robot Vision Sensor

NASA Astrophysics Data System (ADS)

Ren, Y. J.; Zhu, J. G.; Yang, X. Y.; Ye, S. H.

2006-10-01

The Virtex-II Pro FPGA is applied to the vision sensor tracking system of IRB2400 robot. The hardware platform, which undertakes the task of improving SNR and compressing data, is constructed by using the high-speed image processing of FPGA. The lower level image-processing algorithm is realized by combining the FPGA frame and the embedded CPU. The velocity of image processing is accelerated due to the introduction of FPGA and CPU. The usage of the embedded CPU makes it easily to realize the logic design of interface. Some key techniques are presented in the text, such as read-write process, template matching, convolution, and some modules are simulated too. In the end, the compare among the modules using this design, using the PC computer and using the DSP, is carried out. Because the high-speed image processing system core is a chip of FPGA, the function of which can renew conveniently, therefore, to a degree, the measure system is intelligent.

CMOS Image Sensors for High Speed Applications.

PubMed

El-Desouki, Munir; Deen, M Jamal; Fang, Qiyin; Liu, Louis; Tse, Frances; Armstrong, David

2009-01-01

Recent advances in deep submicron CMOS technologies and improved pixel designs have enabled CMOS-based imagers to surpass charge-coupled devices (CCD) imaging technology for mainstream applications. The parallel outputs that CMOS imagers can offer, in addition to complete camera-on-a-chip solutions due to being fabricated in standard CMOS technologies, result in compelling advantages in speed and system throughput. Since there is a practical limit on the minimum pixel size (4∼5 μm) due to limitations in the optics, CMOS technology scaling can allow for an increased number of transistors to be integrated into the pixel to improve both detection and signal processing. Such smart pixels truly show the potential of CMOS technology for imaging applications allowing CMOS imagers to achieve the image quality and global shuttering performance necessary to meet the demands of ultrahigh-speed applications. In this paper, a review of CMOS-based high-speed imager design is presented and the various implementations that target ultrahigh-speed imaging are described. This work also discusses the design, layout and simulation results of an ultrahigh acquisition rate CMOS active-pixel sensor imager that can take 8 frames at a rate of more than a billion frames per second (fps).

Thread concept for automatic task parallelization in image analysis

NASA Astrophysics Data System (ADS)

Lueckenhaus, Maximilian; Eckstein, Wolfgang

1998-09-01

Parallel processing of image analysis tasks is an essential method to speed up image processing and helps to exploit the full capacity of distributed systems. However, writing parallel code is a difficult and time-consuming process and often leads to an architecture-dependent program that has to be re-implemented when changing the hardware. Therefore it is highly desirable to do the parallelization automatically. For this we have developed a special kind of thread concept for image analysis tasks. Threads derivated from one subtask may share objects and run in the same context but may process different threads of execution and work on different data in parallel. In this paper we describe the basics of our thread concept and show how it can be used as basis of an automatic task parallelization to speed up image processing. We further illustrate the design and implementation of an agent-based system that uses image analysis threads for generating and processing parallel programs by taking into account the available hardware. The tests made with our system prototype show that the thread concept combined with the agent paradigm is suitable to speed up image processing by an automatic parallelization of image analysis tasks.

Dynamic autofocus for continuous-scanning time-delay-and-integration image acquisition in automated microscopy.

PubMed

Bravo-Zanoguera, Miguel E; Laris, Casey A; Nguyen, Lam K; Oliva, Mike; Price, Jeffrey H

2007-01-01

Efficient image cytometry of a conventional microscope slide means rapid acquisition and analysis of 20 gigapixels of image data (at 0.3-microm sampling). The voluminous data motivate increased acquisition speed to enable many biomedical applications. Continuous-motion time-delay-and-integrate (TDI) scanning has the potential to speed image acquisition while retaining sensitivity, but the challenge of implementing high-resolution autofocus operating simultaneously with acquisition has limited its adoption. We develop a dynamic autofocus system for this need using: 1. a "volume camera," consisting of nine fiber optic imaging conduits to charge-coupled device (CCD) sensors, that acquires images in parallel from different focal planes, 2. an array of mixed analog-digital processing circuits that measure the high spatial frequencies of the multiple image streams to create focus indices, and 3. a software system that reads and analyzes the focus data streams and calculates best focus for closed feedback loop control. Our system updates autofocus at 56 Hz (or once every 21 microm of stage travel) to collect sharply focused images sampled at 0.3x0.3 microm(2)/pixel at a stage speed of 2.3 mms. The system, tested by focusing in phase contrast and imaging long fluorescence strips, achieves high-performance closed-loop image-content-based autofocus in continuous scanning for the first time.

Digital micromirror device-based laser-illumination Fourier ptychographic microscopy

PubMed Central

Kuang, Cuifang; Ma, Ye; Zhou, Renjie; Lee, Justin; Barbastathis, George; Dasari, Ramachandra R.; Yaqoob, Zahid; So, Peter T. C.

2015-01-01

We report a novel approach to Fourier ptychographic microscopy (FPM) by using a digital micromirror device (DMD) and a coherent laser source (532 nm) for generating spatially modulated sample illumination. Previously demonstrated FPM systems are all based on partially-coherent illumination, which offers limited throughput due to insufficient brightness. Our FPM employs a high power coherent laser source to enable shot-noise limited high-speed imaging. For the first time, a digital micromirror device (DMD), imaged onto the back focal plane of the illumination objective, is used to generate spatially modulated sample illumination field for ptychography. By coding the on/off states of the micromirrors, the illumination plane wave angle can be varied at speeds more than 4 kHz. A set of intensity images, resulting from different oblique illuminations, are used to numerically reconstruct one high-resolution image without obvious laser speckle. Experiments were conducted using a USAF resolution target and a fiber sample, demonstrating high-resolution imaging capability of our system. We envision that our approach, if combined with a coded-aperture compressive-sensing algorithm, will further improve the imaging speed in DMD-based FPM systems. PMID:26480361

Digital micromirror device-based laser-illumination Fourier ptychographic microscopy.

PubMed

Kuang, Cuifang; Ma, Ye; Zhou, Renjie; Lee, Justin; Barbastathis, George; Dasari, Ramachandra R; Yaqoob, Zahid; So, Peter T C

2015-10-19

We report a novel approach to Fourier ptychographic microscopy (FPM) by using a digital micromirror device (DMD) and a coherent laser source (532 nm) for generating spatially modulated sample illumination. Previously demonstrated FPM systems are all based on partially-coherent illumination, which offers limited throughput due to insufficient brightness. Our FPM employs a high power coherent laser source to enable shot-noise limited high-speed imaging. For the first time, a digital micromirror device (DMD), imaged onto the back focal plane of the illumination objective, is used to generate spatially modulated sample illumination field for ptychography. By coding the on/off states of the micromirrors, the illumination plane wave angle can be varied at speeds more than 4 kHz. A set of intensity images, resulting from different oblique illuminations, are used to numerically reconstruct one high-resolution image without obvious laser speckle. Experiments were conducted using a USAF resolution target and a fiber sample, demonstrating high-resolution imaging capability of our system. We envision that our approach, if combined with a coded-aperture compressive-sensing algorithm, will further improve the imaging speed in DMD-based FPM systems.

[Development of a video image system for wireless capsule endoscopes based on DSP].

PubMed

Yang, Li; Peng, Chenglin; Wu, Huafeng; Zhao, Dechun; Zhang, Jinhua

2008-02-01

A video image recorder to record video picture for wireless capsule endoscopes was designed. TMS320C6211 DSP of Texas Instruments Inc. is the core processor of this system. Images are periodically acquired from Composite Video Broadcast Signal (CVBS) source and scaled by video decoder (SAA7114H). Video data is transported from high speed buffer First-in First-out (FIFO) to Digital Signal Processor (DSP) under the control of Complex Programmable Logic Device (CPLD). This paper adopts JPEG algorithm for image coding, and the compressed data in DSP was stored to Compact Flash (CF) card. TMS320C6211 DSP is mainly used for image compression and data transporting. Fast Discrete Cosine Transform (DCT) algorithm and fast coefficient quantization algorithm are used to accelerate operation speed of DSP and decrease the executing code. At the same time, proper address is assigned for each memory, which has different speed;the memory structure is also optimized. In addition, this system uses plenty of Extended Direct Memory Access (EDMA) to transport and process image data, which results in stable and high performance.

High-speed OCT light sources and systems [Invited

PubMed Central

Klein, Thomas; Huber, Robert

2017-01-01

Imaging speed is one of the most important parameters that define the performance of optical coherence tomography (OCT) systems. During the last two decades, OCT speed has increased by over three orders of magnitude. New developments in wavelength-swept lasers have repeatedly been crucial for this development. In this review, we discuss the historical evolution and current state of the art of high-speed OCT systems, with focus on wavelength swept light sources and swept source OCT systems. PMID:28270988

Concepts for on-board satellite image registration. Volume 2: IAS prototype performance evaluation standard definition. [NEEDS Information Adaptive System

NASA Technical Reports Server (NTRS)

Daluge, D. R.; Ruedger, W. H.

1981-01-01

Problems encountered in testing onboard signal processing hardware designed to achieve radiometric and geometric correction of satellite imaging data are considered. These include obtaining representative image and ancillary data for simulation and the transfer and storage of a large quantity of image data at very high speed. The high resolution, high speed preprocessing of LANDSAT-D imagery is considered.

High-speed Raman-encoded molecular imaging of freshly excised tissue surfaces with topically applied SERRS nanoparticles

NASA Astrophysics Data System (ADS)

Wang, Yu "Winston"; Yang, Qian; Kang, Soyoung; Wall, Matthew A.; Liu, Jonathan T. C.

2018-04-01

Surface-enhanced Raman scattering (SERS) nanoparticles (NPs) are increasingly being engineered for a variety of disease-detection and treatment applications. For example, we have previously developed a fiber-optic Raman-encoded molecular imaging (REMI) system for spectral imaging of biomarker-targeted SERS NPs topically applied on tissue surfaces to identify residual tumors at surgical margins. Although accurate tumor detection was achieved, the commercial SERS NPs used in our previous studies lacked the signal strength to enable high-speed imaging with high pixel counts (large fields of view and/or high spatial resolution), which limits their use for certain time-constrained clinical applications. As a solution, we explored the use of surface-enhanced resonant Raman scattering (SERRS) NPs to enhance imaging speeds. The SERRS NPs were synthesized de novo, and then conjugated to HER2 antibodies to achieve high binding affinity, as validated by flow cytometry. Under identical tissue-staining and imaging conditions, the targeted SERRS NPs enabled reliable identification of HER2-overexpressed tumor xenografts with 50-fold-enhanced imaging speed compared with our standard targeted SERS NPs. This enables our REMI system to image tissue surfaces at a rate of 150 cm2 per minute at a spatial resolution of 0.5 mm.

High speed imaging television system

DOEpatents

Wilkinson, William O.; Rabenhorst, David W.

1984-01-01

A television system for observing an event which provides a composite video output comprising the serially interlaced images the system is greater than the time resolution of any of the individual cameras.

High-speed pre-clinical brain imaging using pulsed laser diode based photoacoustic tomography (PLD-PAT) system

NASA Astrophysics Data System (ADS)

Upputuri, Paul Kumar; Pramanik, Manojit

2016-03-01

Photoacoustic tomography (PAT) is a promising biomedical imaging modality for small animal imaging, breast cancer imaging, monitoring of vascularisation, tumor angiogenesis, blood oxygenation, total haemoglobin concentration etc. The existing PAT systems that uses Q-switched Nd:YAG and OPO nanosecond lasers have limitations in clinical applications because they are expensive, non-potable and not suitable for real-time imaging due to their low pulse repetition rate. Low-energy pulsed near-infrared diode laser which are low-cost, compact, and light-weight (<200 grams), can be used as an alternate. In this work, we present a photoacoustic tomography system with a pulsed laser diode (PLD) that can nanosecond pulses with pulse energy 1.3 mJ/pulse at ~803 nm wavelength and 7000 Hz repetition rate. The PLD is integrated inside a single-detector circular scanning geometric system. To verify the high speed imaging capabilities of the PLD-PAT system, we performed in vivo experimental results on small animal brain imaging using this system. The proposed system is portable, low-cost and can provide real-time imaging.

High speed spectral domain optical coherence tomography for retinal imaging at 500,000 A‑lines per second

PubMed Central

An, Lin; Li, Peng; Shen, Tueng T.; Wang, Ruikang

2011-01-01

We present a new development of ultrahigh speed spectral domain optical coherence tomography (SDOCT) for human retinal imaging at 850 nm central wavelength by employing two high-speed line scan CMOS cameras, each running at 250 kHz. Through precisely controlling the recording and reading time periods of the two cameras, the SDOCT system realizes an imaging speed at 500,000 A-lines per second, while maintaining both high axial resolution (~8 μm) and acceptable depth ranging (~2.5 mm). With this system, we propose two scanning protocols for human retinal imaging. The first is aimed to achieve isotropic dense sampling and fast scanning speed, enabling a 3D imaging within 0.72 sec for a region covering 4x4 mm2. In this case, the B-frame rate is 700 Hz and the isotropic dense sampling is 500 A-lines along both the fast and slow axes. This scanning protocol minimizes the motion artifacts, thus making it possible to perform two directional averaging so that the signal to noise ratio of the system is enhanced while the degradation of its resolution is minimized. The second protocol is designed to scan the retina in a large field of view, in which 1200 A-lines are captured along both the fast and slow axes, covering 10 mm2, to provide overall information about the retinal status. Because of relatively long imaging time (4 seconds for a 3D scan), the motion artifact is inevitable, making it difficult to interpret the 3D data set, particularly in a way of depth-resolved en-face fundus images. To mitigate this difficulty, we propose to use the relatively high reflecting retinal pigmented epithelium layer as the reference to flatten the original 3D data set along both the fast and slow axes. We show that the proposed system delivers superb performance for human retina imaging. PMID:22025983

High speed spectral domain optical coherence tomography for retinal imaging at 500,000 A‑lines per second.

PubMed

An, Lin; Li, Peng; Shen, Tueng T; Wang, Ruikang

2011-10-01

We present a new development of ultrahigh speed spectral domain optical coherence tomography (SDOCT) for human retinal imaging at 850 nm central wavelength by employing two high-speed line scan CMOS cameras, each running at 250 kHz. Through precisely controlling the recording and reading time periods of the two cameras, the SDOCT system realizes an imaging speed at 500,000 A-lines per second, while maintaining both high axial resolution (~8 μm) and acceptable depth ranging (~2.5 mm). With this system, we propose two scanning protocols for human retinal imaging. The first is aimed to achieve isotropic dense sampling and fast scanning speed, enabling a 3D imaging within 0.72 sec for a region covering 4x4 mm(2). In this case, the B-frame rate is 700 Hz and the isotropic dense sampling is 500 A-lines along both the fast and slow axes. This scanning protocol minimizes the motion artifacts, thus making it possible to perform two directional averaging so that the signal to noise ratio of the system is enhanced while the degradation of its resolution is minimized. The second protocol is designed to scan the retina in a large field of view, in which 1200 A-lines are captured along both the fast and slow axes, covering 10 mm(2), to provide overall information about the retinal status. Because of relatively long imaging time (4 seconds for a 3D scan), the motion artifact is inevitable, making it difficult to interpret the 3D data set, particularly in a way of depth-resolved en-face fundus images. To mitigate this difficulty, we propose to use the relatively high reflecting retinal pigmented epithelium layer as the reference to flatten the original 3D data set along both the fast and slow axes. We show that the proposed system delivers superb performance for human retina imaging.

Advances in indirect detector systems for ultra high-speed hard X-ray imaging with synchrotron light

NASA Astrophysics Data System (ADS)

Olbinado, M. P.; Grenzer, J.; Pradel, P.; De Resseguier, T.; Vagovic, P.; Zdora, M.-C.; Guzenko, V. A.; David, C.; Rack, A.

2018-04-01

We report on indirect X-ray detector systems for various full-field, ultra high-speed X-ray imaging methodologies, such as X-ray phase-contrast radiography, diffraction topography, grating interferometry and speckle-based imaging performed at the hard X-ray imaging beamline ID19 of the European Synchrotron—ESRF. Our work highlights the versatility of indirect X-ray detectors to multiple goals such as single synchrotron pulse isolation, multiple-frame recording up to millions frames per second, high efficiency, and high spatial resolution. Besides the technical advancements, potential applications are briefly introduced and discussed.

A Novel Speed Compensation Method for ISAR Imaging with Low SNR

PubMed Central

Liu, Yongxiang; Zhang, Shuanghui; Zhu, Dekang; Li, Xiang

2015-01-01

In this paper, two novel speed compensation algorithms for ISAR imaging under a low signal-to-noise ratio (SNR) condition have been proposed, which are based on the cubic phase function (CPF) and the integrated cubic phase function (ICPF), respectively. These two algorithms can estimate the speed of the target from the wideband radar echo directly, which breaks the limitation of speed measuring in a radar system. With the utilization of non-coherent accumulation, the ICPF-based speed compensation algorithm is robust to noise and can meet the requirement of speed compensation for ISAR imaging under a low SNR condition. Moreover, a fast searching implementation strategy, which consists of coarse search and precise search, has been introduced to decrease the computational burden of speed compensation based on CPF and ICPF. Experimental results based on radar data validate the effectiveness of the proposed algorithms. PMID:26225980

Remote sensor digital image data analysis using the General Electric Image 100 analysis system (a study of analysis speed, cost, and performance)

NASA Technical Reports Server (NTRS)

Mcmurtry, G. J.; Petersen, G. W. (Principal Investigator)

1975-01-01

The author has identified the following significant results. It was found that the high speed man machine interaction capability is a distinct advantage of the image 100; however, the small size of the digital computer in the system is a definite limitation. The system can be highly useful in an analysis mode in which it complements a large general purpose computer. The image 100 was found to be extremely valuable in the analysis of aircraft MSS data where the spatial resolution begins to approach photographic quality and the analyst can exercise interpretation judgements and readily interact with the machine.

Vibration compensation for high speed scanning tunneling microscopy

NASA Astrophysics Data System (ADS)

Croft, D.; Devasia, S.

1999-12-01

Low scanning speed is a fundamental limitation of scanning tunneling microscopes (STMs), making real time imaging of surface processes and nanofabrication impractical. The effective scanning bandwidth is currently limited by the smallest resonant vibrational frequency of the piezobased positioning system (i.e., scanner) used in the STM. Due to this limitation, the acquired images are distorted during high speed operations. In practice, the achievable scan rates are much less than 1/10th of the resonant vibrational frequency of the STM scanner. To alleviate the scanning speed limitation, this article describes an inversion-based approach that compensates for the structural vibrations in the scanner and thus, allows STM imaging at high scanning speeds (relative to the smallest resonant vibrational frequency). Experimental results are presented to show the increase in scanning speeds achievable by applying the vibration compensation methods.

HIGH SPEED KERR CELL FRAMING CAMERA

DOEpatents

Goss, W.C.; Gilley, L.F.

1964-01-01

The present invention relates to a high speed camera utilizing a Kerr cell shutter and a novel optical delay system having no moving parts. The camera can selectively photograph at least 6 frames within 9 x 10/sup -8/ seconds during any such time interval of an occurring event. The invention utilizes particularly an optical system which views and transmits 6 images of an event to a multi-channeled optical delay relay system. The delay relay system has optical paths of successively increased length in whole multiples of the first channel optical path length, into which optical paths the 6 images are transmitted. The successively delayed images are accepted from the exit of the delay relay system by an optical image focusing means, which in turn directs the images into a Kerr cell shutter disposed to intercept the image paths. A camera is disposed to simultaneously view and record the 6 images during a single exposure of the Kerr cell shutter. (AEC)

A deep-sea, high-speed, stereoscopic imaging system for in situ measurement of natural seep bubble and droplet characteristics

NASA Astrophysics Data System (ADS)

Wang, Binbin; Socolofsky, Scott A.

2015-10-01

Development, testing, and application of a deep-sea, high-speed, stereoscopic imaging system are presented. The new system is designed for field-ready deployment, focusing on measurement of the characteristics of natural seep bubbles and droplets with high-speed and high-resolution image capture. The stereo view configuration allows precise evaluation of the physical scale of the moving particles in image pairs. Two laboratory validation experiments (a continuous bubble chain and an airstone bubble plume) were carried out to test the calibration procedure, performance of image processing and bubble matching algorithms, three-dimensional viewing, and estimation of bubble size distribution and volumetric flow rate. The results showed that the stereo view was able to improve the individual bubble size measurement over the single-camera view by up to 90% in the two validation cases, with the single-camera being biased toward overestimation of the flow rate. We also present the first application of this imaging system in a study of natural gas seeps in the Gulf of Mexico. The high-speed images reveal the rigidity of the transparent bubble interface, indicating the presence of clathrate hydrate skins on the natural gas bubbles near the source (lowest measurement 1.3 m above the vent). We estimated the dominant bubble size at the seep site Sleeping Dragon in Mississippi Canyon block 118 to be in the range of 2-4 mm and the volumetric flow rate to be 0.2-0.3 L/min during our measurements from 17 to 21 July 2014.

Superficial ultrasound shear wave speed measurements in soft and hard elasticity phantoms: repeatability and reproducibility using two ultrasound systems.

PubMed

Dillman, Jonathan R; Chen, Shigao; Davenport, Matthew S; Zhao, Heng; Urban, Matthew W; Song, Pengfei; Watcharotone, Kuanwong; Carson, Paul L

2015-03-01

There is a paucity of data available regarding the repeatability and reproducibility of superficial shear wave speed (SWS) measurements at imaging depths relevant to the pediatric population. To assess the repeatability and reproducibility of superficial shear wave speed measurements acquired from elasticity phantoms at varying imaging depths using three imaging methods, two US systems and multiple operators. Soft and hard elasticity phantoms manufactured by Computerized Imaging Reference Systems Inc. (Norfolk, VA) were utilized for our investigation. Institution No. 1 used an Acuson S3000 US system (Siemens Medical Solutions USA, Malvern, PA) and three shear wave imaging method/transducer combinations, while institution No. 2 used an Aixplorer US system (SuperSonic Imagine, Bothell, WA) and two different transducers. Ten stiffness measurements were acquired from each phantom at three depths (1.0 cm, 2.5 cm and 4.0 cm) by four operators at each institution. Student's t-test was used to compare SWS measurements between imaging techniques, while SWS measurement agreement was assessed with two-way random effects single-measure intra-class correlation coefficients (ICCs) and coefficients of variation. Mixed model regression analysis determined the effect of predictor variables on SWS measurements. For the soft phantom, the average of mean SWS measurements across the various imaging methods and depths was 0.84 ± 0.04 m/s (mean ± standard deviation) for the Acuson S3000 system and 0.90 ± 0.02 m/s for the Aixplorer system (P = 0.003). For the hard phantom, the average of mean SWS measurements across the various imaging methods and depths was 2.14 ± 0.08 m/s for the Acuson S3000 system and 2.07 ± 0.03 m/s Aixplorer system (P > 0.05). The coefficients of variation were low (0.5-6.8%), and interoperator agreement was near-perfect (ICCs ≥ 0.99). Shear wave imaging method and imaging depth significantly affected measured SWS (P < 0.0001). Superficial shear wave speed measurements in elasticity phantoms demonstrate minimal variability across imaging method/transducer combinations, imaging depths and operators. The exact clinical significance of this variation is uncertain and may change according to organ and specific disease state.

Generation of chemical movies: FT-IR spectroscopic imaging of segmented flows.

PubMed

Chan, K L Andrew; Niu, X; deMello, A J; Kazarian, S G

2011-05-01

We have previously demonstrated that FT-IR spectroscopic imaging can be used as a powerful, label-free detection method for studying laminar flows. However, to date, the speed of image acquisition has been too slow for the efficient detection of moving droplets within segmented flow systems. In this paper, we demonstrate the extraction of fast FT-IR images with acquisition times of 50 ms. This approach allows efficient interrogation of segmented flow systems where aqueous droplets move at a speed of 2.5 mm/s. Consecutive FT-IR images separated by 120 ms intervals allow the generation of chemical movies at eight frames per second. The technique has been applied to the study of microfluidic systems containing moving droplets of water in oil and droplets of protein solution in oil. The presented work demonstrates the feasibility of the use of FT-IR imaging to study dynamic systems with subsecond temporal resolution.

High speed photography, videography, and photonics III; Proceedings of the Meeting, San Diego, CA, August 22, 23, 1985

NASA Technical Reports Server (NTRS)

Ponseggi, B. G. (Editor); Johnson, H. C. (Editor)

1985-01-01

Papers are presented on the picosecond electronic framing camera, photogrammetric techniques using high-speed cineradiography, picosecond semiconductor lasers for characterizing high-speed image shutters, the measurement of dynamic strain by high-speed moire photography, the fast framing camera with independent frame adjustments, design considerations for a data recording system, and nanosecond optical shutters. Consideration is given to boundary-layer transition detectors, holographic imaging, laser holographic interferometry in wind tunnels, heterodyne holographic interferometry, a multispectral video imaging and analysis system, a gated intensified camera, a charge-injection-device profile camera, a gated silicon-intensified-target streak tube and nanosecond-gated photoemissive shutter tubes. Topics discussed include high time-space resolved photography of lasers, time-resolved X-ray spectrographic instrumentation for laser studies, a time-resolving X-ray spectrometer, a femtosecond streak camera, streak tubes and cameras, and a short pulse X-ray diagnostic development facility.

Network-linked long-time recording high-speed video camera system

NASA Astrophysics Data System (ADS)

Kimura, Seiji; Tsuji, Masataka

2001-04-01

This paper describes a network-oriented, long-recording-time high-speed digital video camera system that utilizes an HDD (Hard Disk Drive) as a recording medium. Semiconductor memories (DRAM, etc.) are the most common image data recording media with existing high-speed digital video cameras. They are extensively used because of their advantage of high-speed writing and reading of picture data. The drawback is that their recording time is limited to only several seconds because the data amount is very large. A recording time of several seconds is sufficient for many applications. However, a much longer recording time is required in some applications where an exact prediction of trigger timing is hard to make. In the Late years, the recording density of the HDD has been dramatically improved, which has attracted more attention to its value as a long-recording-time medium. We conceived an idea that we would be able to build a compact system that makes possible a long time recording if the HDD can be used as a memory unit for high-speed digital image recording. However, the data rate of such a system, capable of recording 640 X 480 pixel resolution pictures at 500 frames per second (fps) with 8-bit grayscale is 153.6 Mbyte/sec., and is way beyond the writing speed of the commonly used HDD. So, we developed a dedicated image compression system and verified its capability to lower the data rate from the digital camera to match the HDD writing rate.

[Construction of DICOM-WWW gateway by open source, and application to PDAs using the high-speed mobile communications network].

PubMed

Yokohama, Noriya

2003-09-01

The author constructed a medical image network system using open source software that took security into consideration. This system was enabled for search and browse with a WWW browser, and images were stored in a DICOM server. In order to realize this function, software was developed to fill in the gap between the DICOM protocol and HTTP using PHP language. The transmission speed was evaluated by the difference in protocols between DICOM and HTTP. Furthermore, an attempt was made to evaluate the convenience of medical image access with a personal information terminal via the Internet through the high-speed mobile communication terminal. Results suggested the feasibility of remote diagnosis and application to emergency care.

High-Speed Noninvasive Eye-Tracking System

NASA Technical Reports Server (NTRS)

Talukder, Ashit; LaBaw, Clayton; Michael-Morookian, John; Monacos, Steve; Serviss, Orin

2007-01-01

The figure schematically depicts a system of electronic hardware and software that noninvasively tracks the direction of a person s gaze in real time. Like prior commercial noninvasive eye-tracking systems, this system is based on (1) illumination of an eye by a low-power infrared light-emitting diode (LED); (2) acquisition of video images of the pupil, iris, and cornea in the reflected infrared light; (3) digitization of the images; and (4) processing the digital image data to determine the direction of gaze from the centroids of the pupil and cornea in the images. Relative to the prior commercial systems, the present system operates at much higher speed and thereby offers enhanced capability for applications that involve human-computer interactions, including typing and computer command and control by handicapped individuals,and eye-based diagnosis of physiological disorders that affect gaze responses.

Programmable Illumination and High-Speed, Multi-Wavelength, Confocal Microscopy Using a Digital Micromirror

PubMed Central

Martial, Franck P.; Hartell, Nicholas A.

2012-01-01

Confocal microscopy is routinely used for high-resolution fluorescence imaging of biological specimens. Most standard confocal systems scan a laser across a specimen and collect emitted light passing through a single pinhole to produce an optical section of the sample. Sequential scanning on a point-by-point basis limits the speed of image acquisition and even the fastest commercial instruments struggle to resolve the temporal dynamics of rapid cellular events such as calcium signals. Various approaches have been introduced that increase the speed of confocal imaging. Nipkov disk microscopes, for example, use arrays of pinholes or slits on a spinning disk to achieve parallel scanning which significantly increases the speed of acquisition. Here we report the development of a microscope module that utilises a digital micromirror device as a spatial light modulator to provide programmable confocal optical sectioning with a single camera, at high spatial and axial resolution at speeds limited by the frame rate of the camera. The digital micromirror acts as a solid state Nipkov disk but with the added ability to change the pinholes size and separation and to control the light intensity on a mirror-by-mirror basis. The use of an arrangement of concave and convex mirrors in the emission pathway instead of lenses overcomes the astigmatism inherent with DMD devices, increases light collection efficiency and ensures image collection is achromatic so that images are perfectly aligned at different wavelengths. Combined with non-laser light sources, this allows low cost, high-speed, multi-wavelength image acquisition without the need for complex wavelength-dependent image alignment. The micromirror can also be used for programmable illumination allowing spatially defined photoactivation of fluorescent proteins. We demonstrate the use of this system for high-speed calcium imaging using both a single wavelength calcium indicator and a genetically encoded, ratiometric, calcium sensor. PMID:22937130

Programmable illumination and high-speed, multi-wavelength, confocal microscopy using a digital micromirror.

PubMed

Martial, Franck P; Hartell, Nicholas A

2012-01-01

Confocal microscopy is routinely used for high-resolution fluorescence imaging of biological specimens. Most standard confocal systems scan a laser across a specimen and collect emitted light passing through a single pinhole to produce an optical section of the sample. Sequential scanning on a point-by-point basis limits the speed of image acquisition and even the fastest commercial instruments struggle to resolve the temporal dynamics of rapid cellular events such as calcium signals. Various approaches have been introduced that increase the speed of confocal imaging. Nipkov disk microscopes, for example, use arrays of pinholes or slits on a spinning disk to achieve parallel scanning which significantly increases the speed of acquisition. Here we report the development of a microscope module that utilises a digital micromirror device as a spatial light modulator to provide programmable confocal optical sectioning with a single camera, at high spatial and axial resolution at speeds limited by the frame rate of the camera. The digital micromirror acts as a solid state Nipkov disk but with the added ability to change the pinholes size and separation and to control the light intensity on a mirror-by-mirror basis. The use of an arrangement of concave and convex mirrors in the emission pathway instead of lenses overcomes the astigmatism inherent with DMD devices, increases light collection efficiency and ensures image collection is achromatic so that images are perfectly aligned at different wavelengths. Combined with non-laser light sources, this allows low cost, high-speed, multi-wavelength image acquisition without the need for complex wavelength-dependent image alignment. The micromirror can also be used for programmable illumination allowing spatially defined photoactivation of fluorescent proteins. We demonstrate the use of this system for high-speed calcium imaging using both a single wavelength calcium indicator and a genetically encoded, ratiometric, calcium sensor.

An optical system for detecting 3D high-speed oscillation of a single ultrasound microbubble

PubMed Central

Liu, Yuan; Yuan, Baohong

2013-01-01

As contrast agents, microbubbles have been playing significant roles in ultrasound imaging. Investigation of microbubble oscillation is crucial for microbubble characterization and detection. Unfortunately, 3-dimensional (3D) observation of microbubble oscillation is challenging and costly because of the bubble size—a few microns in diameter—and the high-speed dynamics under MHz ultrasound pressure waves. In this study, a cost-efficient optical confocal microscopic system combined with a gated and intensified charge-coupled device (ICCD) camera were developed to detect 3D microbubble oscillation. The capability of imaging microbubble high-speed oscillation with much lower costs than with an ultra-fast framing or streak camera system was demonstrated. In addition, microbubble oscillations along both lateral (x and y) and axial (z) directions were demonstrated. Accordingly, this system is an excellent alternative for 3D investigation of microbubble high-speed oscillation, especially when budgets are limited. PMID:24049677

High-speed and ultrahigh-speed cinematographic recording techniques

NASA Astrophysics Data System (ADS)

Miquel, J. C.

1980-12-01

A survey is presented of various high-speed and ultrahigh-speed cinematographic recording systems (covering a range of speeds from 100 to 14-million pps). Attention is given to the functional and operational characteristics of cameras and to details of high-speed cinematography techniques (including image processing, and illumination). A list of cameras (many of them French) available in 1980 is presented

High-speed broadband nanomechanical property quantification and imaging of life science materials using atomic force microscope

NASA Astrophysics Data System (ADS)

Ren, Juan

Nanoscale morphological characterization and mechanical properties quantification of soft and biological materials play an important role in areas ranging from nano-composite material synthesis and characterization, cellular mechanics to drug design. Frontier studies in these areas demand the coordination between nanoscale morphological evolution and mechanical behavior variations through simultaneous measurement of these two aspects of properties. Atomic force microscope (AFM) is very promising in achieving such simultaneous measurements at high-speed and broadband owing to its unique capability in applying force stimuli and then, measuring the response at specific locations in a physiologically friendly environment with pico-newton force and nanometer spatial resolution. Challenges, however, arise as current AFM systems are unable to account for the complex and coupled dynamics of the measurement system and probe-sample interaction during high-speed imaging and broadband measurements. In this dissertation, the creation of a set of dynamics and control tools to probe-based high-speed imaging and rapid broadband nanomechanical spectroscopy of soft and biological materials are presented. Firstly, advanced control-based approaches are presented to improve the imaging performance of AFM imaging both in air and in liquid. An adaptive contact mode (ACM) imaging scheme is proposed to replace the traditional contact mode (CM) imaging by addressing the major concerns in both the speed and the force exerted to the sample. In this work, the image distortion caused by the topography tracking error is accounted for in the topography quantification and the quantified sample topography is utilized in a gradient-based optimization method to adjust the cantilever deflection set-point for each scanline closely around the minimal level needed for maintaining a stable probe-sample contact, and a data-driven iterative feedforward control that utilizes a prediction of the next-line tracking is implemented to enhance the sample topography tracking. An adaptive multi-loop mode (AMLM) imaging approach is proposed to substantially increase the imaging speed of tapping mode (TM) while preserving the advantages of TM over CM by integrating an inner-outer feedback control loop to regulate the TM-deflection on top of the conventional TM-amplitude feedback control to improve the sample topography tracking. Experiments demonstrated that the proposed ACM and AMLM are capable of increasing the imaging speed by at least 20 times for conventional contact and tapping mode imaging, respectively, with no loss of imaging quality and well controlled tip-sample interaction force. In addition, an adaptive mode imaging for in-liquid topography quantification on live cells is presented. The experiment results demonstrated that instead of keeping constant scanning speed, the proposed speed optimization scheme is able to increase the imaging speed on live human prostate cancer cells by at least eight-fold with no loss of imaging quality. Secondly, control based approaches to accurate nanomechanical quantification on soft materials for both broadband and in-liquid force-curve measurements are proposed to address the adverse effects caused by the system coupling dynamics and the cantilever acceleration, which were not compensated for by the conventional AFM measurement approach. The proposed nanomechanical measurement approaches are demonstrated through experiments to measure the viscoelastic properties of different polymer samples in air and live human cells in liquid to study the variation of rate-dependent elastic modulus of cervix cancer cell during the epithelial-mesenchymal transition process.

High speed quantitative digital microscopy

NASA Technical Reports Server (NTRS)

Castleman, K. R.; Price, K. H.; Eskenazi, R.; Ovadya, M. M.; Navon, M. A.

1984-01-01

Modern digital image processing hardware makes possible quantitative analysis of microscope images at high speed. This paper describes an application to automatic screening for cervical cancer. The system uses twelve MC6809 microprocessors arranged in a pipeline multiprocessor configuration. Each processor executes one part of the algorithm on each cell image as it passes through the pipeline. Each processor communicates with its upstream and downstream neighbors via shared two-port memory. Thus no time is devoted to input-output operations as such. This configuration is expected to be at least ten times faster than previous systems.

High-speed 3D imaging of cellular activity in the brain using axially-extended beams and light sheets.

PubMed

Hillman, Elizabeth Mc; Voleti, Venkatakaushik; Patel, Kripa; Li, Wenze; Yu, Hang; Perez-Campos, Citlali; Benezra, Sam E; Bruno, Randy M; Galwaduge, Pubudu T

2018-06-01

As optical reporters and modulators of cellular activity have become increasingly sophisticated, the amount that can be learned about the brain via high-speed cellular imaging has increased dramatically. However, despite fervent innovation, point-scanning microscopy is facing a fundamental limit in achievable 3D imaging speeds and fields of view. A range of alternative approaches are emerging, some of which are moving away from point-scanning to use axially-extended beams or sheets of light, for example swept confocally aligned planar excitation (SCAPE) microscopy. These methods are proving effective for high-speed volumetric imaging of the nervous system of small organisms such as Drosophila (fruit fly) and D. Rerio (Zebrafish), and are showing promise for imaging activity in the living mammalian brain using both single and two-photon excitation. This article describes these approaches and presents a simple model that demonstrates key advantages of axially-extended illumination over point-scanning strategies for high-speed volumetric imaging, including longer integration times per voxel, improved photon efficiency and reduced photodamage. Copyright © 2018 Elsevier Ltd. All rights reserved.

Ultrahigh-Speed Optical Coherence Tomography for Three-Dimensional and En Face Imaging of the Retina and Optic Nerve Head

PubMed Central

Srinivasan, Vivek J.; Adler, Desmond C.; Chen, Yueli; Gorczynska, Iwona; Huber, Robert; Duker, Jay S.; Schuman, Joel S.; Fujimoto, James G.

2009-01-01

Purpose To demonstrate ultrahigh-speed optical coherence tomography (OCT) imaging of the retina and optic nerve head at 249,000 axial scans per second and a wavelength of 1060 nm. To investigate methods for visualization of the retina, choroid, and optic nerve using high-density sampling enabled by improved imaging speed. Methods A swept-source OCT retinal imaging system operating at a speed of 249,000 axial scans per second was developed. Imaging of the retina, choroid, and optic nerve were performed. Display methods such as speckle reduction, slicing along arbitrary planes, en face visualization of reflectance from specific retinal layers, and image compounding were investigated. Results High-definition and three-dimensional (3D) imaging of the normal retina and optic nerve head were performed. Increased light penetration at 1060 nm enabled improved visualization of the choroid, lamina cribrosa, and sclera. OCT fundus images and 3D visualizations were generated with higher pixel density and less motion artifacts than standard spectral/Fourier domain OCT. En face images enabled visualization of the porous structure of the lamina cribrosa, nerve fiber layer, choroid, photoreceptors, RPE, and capillaries of the inner retina. Conclusions Ultrahigh-speed OCT imaging of the retina and optic nerve head at 249,000 axial scans per second is possible. The improvement of ∼5 to 10× in imaging speed over commercial spectral/Fourier domain OCT technology enables higher density raster scan protocols and improved performance of en face visualization methods. The combination of the longer wavelength and ultrahigh imaging speed enables excellent visualization of the choroid, sclera, and lamina cribrosa. PMID:18658089

Fourier domain mode locking at 1050 nm for ultra-high-speed optical coherence tomography of the human retina at 236,000 axial scans per second.

PubMed

Huber, R; Adler, D C; Srinivasan, V J; Fujimoto, J G

2007-07-15

A Fourier domain mode-locked (FDML) laser at 1050 nm for ultra-high-speed optical coherence tomography (OCT) imaging of the human retina is demonstrated. Achievable performance, physical limitations, design rules, and scaling principles for FDML operation and component choice in this wavelength range are discussed. The fiber-based FDML laser operates at a sweep rate of 236 kHz over a 63 nm tuning range, with 7 mW average output power. Ultra-high-speed retinal imaging is demonstrated at 236,000 axial scans per second. This represents a speed improvement of approximately10x over typical high-speed OCT systems, paving the way for densely sampled volumetric data sets and new imaging protocols.

Particle Streak Anemometry: A New Method for Proximal Flow Sensing from Aircraft

NASA Astrophysics Data System (ADS)

Nichols, T. W.

Accurate sensing of relative air flow direction from fixed-wing small unmanned aircraft (sUAS) is challenging with existing multi-hole pitot-static and vane systems. Sub-degree direction accuracy is generally not available on such systems and disturbances to the local flow field, induced by the airframe, introduce an additional error source. An optical imaging approach to make a relative air velocity measurement with high-directional accuracy is presented. Optical methods offer the capability to make a proximal measurement in undisturbed air outside of the local flow field without the need to place sensors on vulnerable probes extended ahead of the aircraft. Current imaging flow analysis techniques for laboratory use rely on relatively thin imaged volumes and sophisticated hardware and intensity thresholding in low-background conditions. A new method is derived and assessed using a particle streak imaging technique that can be implemented with low-cost commercial cameras and illumination systems, and can function in imaged volumes of arbitrary depth with complex background signal. The new technique, referred to as particle streak anemometry (PSA) (to differentiate from particle streak velocimetry which makes a field measurement rather than a single bulk flow measurement) utilizes a modified Canny Edge detection algorithm with a connected component analysis and principle component analysis to detect streak ends in complex imaging conditions. A linear solution for the air velocity direction is then implemented with a random sample consensus (RANSAC) solution approach. A single DOF non-linear, non-convex optimization problem is then solved for the air speed through an iterative approach. The technique was tested through simulation and wind tunnel tests yielding angular accuracies under 0.2 degrees, superior to the performance of existing commercial systems. Air speed error standard deviations varied from 1.6 to 2.2 m/s depending on the techniques of implementation. While air speed sensing is secondary to accurate flow direction measurement, the air speed results were in line with commercial pitot static systems at low speeds.

Development of an imaging system for single droplet characterization using a droplet generator.

PubMed

Minov, S Vulgarakis; Cointault, F; Vangeyte, J; Pieters, J G; Hijazi, B; Nuyttens, D

2012-01-01

The spray droplets generated by agricultural nozzles play an important role in the application accuracy and efficiency of plant protection products. The limitations of the non-imaging techniques and the recent improvements in digital image acquisition and processing increased the interest in using high speed imaging techniques in pesticide spray characterisation. The goal of this study was to develop an imaging technique to evaluate the characteristics of a single spray droplet using a piezoelectric single droplet generator and a high speed imaging technique. Tests were done with different camera settings, lenses, diffusers and light sources. The experiments have shown the necessity for having a good image acquisition and processing system. Image analysis results contributed in selecting the optimal set-up for measuring droplet size and velocity which consisted of a high speed camera with a 6 micros exposure time, a microscope lens at a working distance of 43 cm resulting in a field of view of 1.0 cm x 0.8 cm and a Xenon light source without diffuser used as a backlight. For measuring macro-spray characteristics as the droplet trajectory, the spray angle and the spray shape, a Macro Video Zoom lens at a working distance of 14.3 cm with a bigger field of view of 7.5 cm x 9.5 cm in combination with a halogen spotlight with a diffuser and the high speed camera can be used.

High speed imaging of dynamic processes with a switched source x-ray CT system

NASA Astrophysics Data System (ADS)

Thompson, William M.; Lionheart, William R. B.; Morton, Edward J.; Cunningham, Mike; Luggar, Russell D.

2015-05-01

Conventional x-ray computed tomography (CT) scanners are limited in their scanning speed by the mechanical constraints of their rotating gantries and as such do not provide the necessary temporal resolution for imaging of fast-moving dynamic processes, such as moving fluid flows. The Real Time Tomography (RTT) system is a family of fast cone beam CT scanners which instead use multiple fixed discrete sources and complete rings of detectors in an offset geometry. We demonstrate the potential of this system for use in the imaging of such high speed dynamic processes and give results using simulated and real experimental data. The unusual scanning geometry results in some challenges in image reconstruction, which are overcome using algebraic iterative reconstruction techniques and explicit regularisation. Through the use of a simple temporal regularisation term and by optimising the source firing pattern, we show that temporal resolution of the system may be increased at the expense of spatial resolution, which may be advantageous in some situations. Results are given showing temporal resolution of approximately 500 µs with simulated data and 3 ms with real experimental data.

Highly accelerated cardiovascular MR imaging using many channel technology: concepts and clinical applications

PubMed Central

Sodickson, Daniel K.

2010-01-01

Cardiovascular magnetic resonance imaging (CVMRI) is of proven clinical value in the non-invasive imaging of cardiovascular diseases. CVMRI requires rapid image acquisition, but acquisition speed is fundamentally limited in conventional MRI. Parallel imaging provides a means for increasing acquisition speed and efficiency. However, signal-to-noise (SNR) limitations and the limited number of receiver channels available on most MR systems have in the past imposed practical constraints, which dictated the use of moderate accelerations in CVMRI. High levels of acceleration, which were unattainable previously, have become possible with many-receiver MR systems and many-element, cardiac-optimized RF-coil arrays. The resulting imaging speed improvements can be exploited in a number of ways, ranging from enhancement of spatial and temporal resolution to efficient whole heart coverage to streamlining of CVMRI work flow. In this review, examples of these strategies are provided, following an outline of the fundamentals of the highly accelerated imaging approaches employed in CVMRI. Topics discussed include basic principles of parallel imaging; key requirements for MR systems and RF-coil design; practical considerations of SNR management, supported by multi-dimensional accelerations, 3D noise averaging and high field imaging; highly accelerated clinical state-of-the art cardiovascular imaging applications spanning the range from SNR-rich to SNR-limited; and current trends and future directions. PMID:17562047

Performance assessment of 3D surface imaging technique for medical imaging applications

NASA Astrophysics Data System (ADS)

Li, Tuotuo; Geng, Jason; Li, Shidong

2013-03-01

Recent development in optical 3D surface imaging technologies provide better ways to digitalize the 3D surface and its motion in real-time. The non-invasive 3D surface imaging approach has great potential for many medical imaging applications, such as motion monitoring of radiotherapy, pre/post evaluation of plastic surgery and dermatology, to name a few. Various commercial 3D surface imaging systems have appeared on the market with different dimension, speed and accuracy. For clinical applications, the accuracy, reproducibility and robustness across the widely heterogeneous skin color, tone, texture, shape properties, and ambient lighting is very crucial. Till now, a systematic approach for evaluating the performance of different 3D surface imaging systems still yet exist. In this paper, we present a systematic performance assessment approach to 3D surface imaging system assessment for medical applications. We use this assessment approach to exam a new real-time surface imaging system we developed, dubbed "Neo3D Camera", for image-guided radiotherapy (IGRT). The assessments include accuracy, field of view, coverage, repeatability, speed and sensitivity to environment, texture and color.

Speed of sound and photoacoustic imaging with an optical camera based ultrasound detection system

NASA Astrophysics Data System (ADS)

Nuster, Robert; Paltauf, Guenther

2017-07-01

CCD camera based optical ultrasound detection is a promising alternative approach for high resolution 3D photoacoustic imaging (PAI). To fully exploit its potential and to achieve an image resolution <50 μm, it is necessary to incorporate variations of the speed of sound (SOS) in the image reconstruction algorithm. Hence, in the proposed work the idea and a first implementation are shown how speed of sound imaging can be added to a previously developed camera based PAI setup. The current setup provides SOS-maps with a spatial resolution of 2 mm and an accuracy of the obtained absolute SOS values of about 1%. The proposed dual-modality setup has the potential to provide highly resolved and perfectly co-registered 3D photoacoustic and SOS images.

Image acquisition optimization of a limited-angle intrafraction verification (LIVE) system for lung radiotherapy.

PubMed

Zhang, Yawei; Deng, Xinchen; Yin, Fang-Fang; Ren, Lei

2018-01-01

Limited-angle intrafraction verification (LIVE) has been previously developed for four-dimensional (4D) intrafraction target verification either during arc delivery or between three-dimensional (3D)/IMRT beams. Preliminary studies showed that LIVE can accurately estimate the target volume using kV/MV projections acquired over orthogonal view 30° scan angles. Currently, the LIVE imaging acquisition requires slow gantry rotation and is not clinically optimized. The goal of this study is to optimize the image acquisition parameters of LIVE for different patient respiratory periods and gantry rotation speeds for the effective clinical implementation of the system. Limited-angle intrafraction verification imaging acquisition was optimized using a digital anthropomorphic phantom (XCAT) with simulated respiratory periods varying from 3 s to 6 s and gantry rotation speeds varying from 1°/s to 6°/s. LIVE scanning time was optimized by minimizing the number of respiratory cycles needed for the four-dimensional scan, and imaging dose was optimized by minimizing the number of kV and MV projections needed for four-dimensional estimation. The estimation accuracy was evaluated by calculating both the center-of-mass-shift (COMS) and three-dimensional volume-percentage-difference (VPD) between the tumor in estimated images and the ground truth images. The robustness of LIVE was evaluated with varied respiratory patterns, tumor sizes, and tumor locations in XCAT simulation. A dynamic thoracic phantom (CIRS) was used to further validate the optimized imaging schemes from XCAT study with changes of respiratory patterns, tumor sizes, and imaging scanning directions. Respiratory periods, gantry rotation speeds, number of respiratory cycles scanned and number of kV/MV projections acquired were all positively correlated with the estimation accuracy of LIVE. Faster gantry rotation speed or longer respiratory period allowed less respiratory cycles to be scanned and less kV/MV projections to be acquired to estimate the target volume accurately. Regarding the scanning time minimization, for patient respiratory periods of 3-4 s, gantry rotation speeds of 1°/s, 2°/s, 3-6°/s required scanning of five, four, and three respiratory cycles, respectively. For patient respiratory periods of 5-6 s, the corresponding respiratory cycles required in the scan changed to four, three, and two cycles, respectively. Regarding the imaging dose minimization, for patient respiratory periods of 3-4 s, gantry rotation speeds of 1°/s, 2-4°/s, 5-6°/s required acquiring of 7, 5, 4 kV and MV projections, respectively. For patient respiratory periods of 5-6 s, 5 kV and 5 MV projections are sufficient for all gantry rotation speeds. The optimized LIVE system was robust against breathing pattern, tumor size and tumor location changes. In the CIRS study, the optimized LIVE system achieved the average center-of-mass-shift (COMS)/volume-percentage-difference (VPD) of 0.3 ± 0.1 mm/7.7 ± 2.0% for the scanning time priority case, 0.2 ± 0.1 mm/6.1 ± 1.2% for the imaging dose priority case, respectively, among all gantry rotation speeds tested. LIVE was robust against different scanning directions investigated. The LIVE system has been preliminarily optimized for different patient respiratory periods and treatment gantry rotation speeds using digital and physical phantoms. The optimized imaging parameters, including number of respiratory cycles scanned and kV/MV projection numbers acquired, provide guidelines for optimizing the scanning time and imaging dose of the LIVE system for its future evaluations and clinical implementations through patient studies. © 2017 American Association of Physicists in Medicine.

Imaging of murine embryonic cardiovascular development using optical coherence tomography (Conference Presentation)

NASA Astrophysics Data System (ADS)

Huang, Yongyang; Degenhardt, Karl R.; Astrof, Sophie; Zhou, Chao

2016-03-01

We have demonstrated the capability of spectral domain optical coherence tomography (SDOCT) system to image full development of mouse embryonic cardiovascular system. Monitoring morphological changes of mouse embryonic heart occurred in different embryonic stages helps identify structural or functional cardiac anomalies and understand how these anomalies lead to congenital heart diseases (CHD) present at birth. In this study, mouse embryo hearts ranging from E9.5 to E15.5 were prepared and imaged in vitro. A customized spectral domain OCT system was used for imaging, with a central wavelength of 1310nm, spectral bandwidth of ~100nm and imaging speed of 47kHz A-scans/s. Axial resolution of this system was 8.3µm in air, and transverse resolution was 6.2 µm with 5X objective. Key features of mouse embryonic cardiovascular development such as vasculature remodeling into circulatory system, separation of atria and ventricles and emergence of valves could be clearly seen in three-dimensional OCT images. Optical clearing was applied to overcome the penetration limit of OCT system. With high resolution, fast imaging speed, 3D imaging capability, OCT proves to be a promising biomedical imaging modality for developmental biology studies, rivaling histology and micro-CT.

In-flight measurements of aircraft propeller deformation by means of an autarkic fast rotating imaging system

NASA Astrophysics Data System (ADS)

Stasicki, Boleslaw; Boden, Fritz

2015-03-01

The non-intrusive in-flight measurement of the deformation and pitch of the aircraft propeller is a demanding task. The idea of an imaging system integrated and rotating with the aircraft propeller has been presented on the 30th International Congress on High-Speed Imaging and Photonics (ICHSIP30) in 2012. Since then this system has been constructed and tested in the laboratory as well as on the real aircraft. In this paper we outline the principle of Image Pattern Correlation Technique (IPCT) based on Digital Image Correlation (DIC) and describe the construction of a dedicated autarkic 3D camera system placed on the investigated propeller and rotating at its full speed. Furthermore, the results of the first ground and in-flight tests are shown and discussed. This development has been found by the European Commission within the 7th frame project AIM2 (contract no. 266107).

SPLASSH: Open source software for camera-based high-speed, multispectral in-vivo optical image acquisition

PubMed Central

Sun, Ryan; Bouchard, Matthew B.; Hillman, Elizabeth M. C.

2010-01-01

Camera-based in-vivo optical imaging can provide detailed images of living tissue that reveal structure, function, and disease. High-speed, high resolution imaging can reveal dynamic events such as changes in blood flow and responses to stimulation. Despite these benefits, commercially available scientific cameras rarely include software that is suitable for in-vivo imaging applications, making this highly versatile form of optical imaging challenging and time-consuming to implement. To address this issue, we have developed a novel, open-source software package to control high-speed, multispectral optical imaging systems. The software integrates a number of modular functions through a custom graphical user interface (GUI) and provides extensive control over a wide range of inexpensive IEEE 1394 Firewire cameras. Multispectral illumination can be incorporated through the use of off-the-shelf light emitting diodes which the software synchronizes to image acquisition via a programmed microcontroller, allowing arbitrary high-speed illumination sequences. The complete software suite is available for free download. Here we describe the software’s framework and provide details to guide users with development of this and similar software. PMID:21258475

High-Speed and Scalable Whole-Brain Imaging in Rodents and Primates.

PubMed

Seiriki, Kaoru; Kasai, Atsushi; Hashimoto, Takeshi; Schulze, Wiebke; Niu, Misaki; Yamaguchi, Shun; Nakazawa, Takanobu; Inoue, Ken-Ichi; Uezono, Shiori; Takada, Masahiko; Naka, Yuichiro; Igarashi, Hisato; Tanuma, Masato; Waschek, James A; Ago, Yukio; Tanaka, Kenji F; Hayata-Takano, Atsuko; Nagayasu, Kazuki; Shintani, Norihito; Hashimoto, Ryota; Kunii, Yasuto; Hino, Mizuki; Matsumoto, Junya; Yabe, Hirooki; Nagai, Takeharu; Fujita, Katsumasa; Matsuda, Toshio; Takuma, Kazuhiro; Baba, Akemichi; Hashimoto, Hitoshi

2017-06-21

Subcellular resolution imaging of the whole brain and subsequent image analysis are prerequisites for understanding anatomical and functional brain networks. Here, we have developed a very high-speed serial-sectioning imaging system named FAST (block-face serial microscopy tomography), which acquires high-resolution images of a whole mouse brain in a speed range comparable to that of light-sheet fluorescence microscopy. FAST enables complete visualization of the brain at a resolution sufficient to resolve all cells and their subcellular structures. FAST renders unbiased quantitative group comparisons of normal and disease model brain cells for the whole brain at a high spatial resolution. Furthermore, FAST is highly scalable to non-human primate brains and human postmortem brain tissues, and can visualize neuronal projections in a whole adult marmoset brain. Thus, FAST provides new opportunities for global approaches that will allow for a better understanding of brain systems in multiple animal models and in human diseases. Copyright © 2017 Elsevier Inc. All rights reserved.

A self-synchronized high speed computational ghost imaging system: A leap towards dynamic capturing

NASA Astrophysics Data System (ADS)

Suo, Jinli; Bian, Liheng; Xiao, Yudong; Wang, Yongjin; Zhang, Lei; Dai, Qionghai

2015-11-01

High quality computational ghost imaging needs to acquire a large number of correlated measurements between the to-be-imaged scene and different reference patterns, thus ultra-high speed data acquisition is of crucial importance in real applications. To raise the acquisition efficiency, this paper reports a high speed computational ghost imaging system using a 20 kHz spatial light modulator together with a 2 MHz photodiode. Technically, the synchronization between such high frequency illumination and bucket detector needs nanosecond trigger precision, so the development of synchronization module is quite challenging. To handle this problem, we propose a simple and effective computational self-synchronization scheme by building a general mathematical model and introducing a high precision synchronization technique. The resulted efficiency is around 14 times faster than state-of-the-arts, and takes an important step towards ghost imaging of dynamic scenes. Besides, the proposed scheme is a general approach with high flexibility for readily incorporating other illuminators and detectors.

Ultrasound Picture Archiving And Communication Systems

NASA Astrophysics Data System (ADS)

Koestner, Ken; Hottinger, C. F.

1982-01-01

The ideal ultrasonic image communication and storage system must be flexible in order to optimize speed and minimize storage requirements. Various ultrasonic imaging modalities are quite different in data volume and speed requirements. Static imaging, for example B-Scanning, involves acquisition of a large amount of data that is averaged or accumulated in a desired manner. The image is then frozen in image memory before transfer and storage. Images are commonly a 512 x 512 point array, each point 6 bits deep. Transfer of such an image over a serial line at 9600 baud would require about three minutes. Faster transfer times are possible; for example, we have developed a parallel image transfer system using direct memory access (DMA) that reduces the time to 16 seconds. Data in this format requires 256K bytes for storage. Data compression can be utilized to reduce these requirements. Real-time imaging has much more stringent requirements for speed and storage. The amount of actual data per frame in real-time imaging is reduced due to physical limitations on ultrasound. For example, 100 scan lines (480 points long, 6 bits deep) can be acquired during a frame at a 30 per second rate. In order to transmit and save this data at a real-time rate requires a transfer rate of 8.6 Megabaud. A real-time archiving system would be complicated by the necessity of specialized hardware to interpolate between scan lines and perform desirable greyscale manipulation on recall. Image archiving for cardiology and radiology would require data transfer at this high rate to preserve temporal (cardiology) and spatial (radiology) information.

Research of aerial imaging spectrometer data acquisition technology based on USB 3.0

NASA Astrophysics Data System (ADS)

Huang, Junze; Wang, Yueming; He, Daogang; Yu, Yanan

2016-11-01

With the emergence of UAV (unmanned aerial vehicle) platform for aerial imaging spectrometer, research of aerial imaging spectrometer DAS(data acquisition system) faces new challenges. Due to the limitation of platform and other factors, the aerial imaging spectrometer DAS requires small-light, low-cost and universal. Traditional aerial imaging spectrometer DAS system is expensive, bulky, non-universal and unsupported plug-and-play based on PCIe. So that has been unable to meet promotion and application of the aerial imaging spectrometer. In order to solve these problems, the new data acquisition scheme bases on USB3.0 interface.USB3.0 can provide guarantee of small-light, low-cost and universal relying on the forward-looking technology advantage. USB3.0 transmission theory is up to 5Gbps.And the GPIF programming interface achieves 3.2Gbps of the effective theoretical data bandwidth.USB3.0 can fully meet the needs of the aerial imaging spectrometer data transmission rate. The scheme uses the slave FIFO asynchronous data transmission mode between FPGA and USB3014 interface chip. Firstly system collects spectral data from TLK2711 of high-speed serial interface chip. Then FPGA receives data in DDR2 cache after ping-pong data processing. Finally USB3014 interface chip transmits data via automatic-dma approach and uploads to PC by USB3.0 cable. During the manufacture of aerial imaging spectrometer, the DAS can achieve image acquisition, transmission, storage and display. All functions can provide the necessary test detection for aerial imaging spectrometer. The test shows that system performs stable and no data lose. Average transmission speed and storage speed of writing SSD can stabilize at 1.28Gbps. Consequently ,this data acquisition system can meet application requirements for aerial imaging spectrometer.

True color blood flow imaging using a high-speed laser photography system

NASA Astrophysics Data System (ADS)

Liu, Chien-Sheng; Lin, Cheng-Hsien; Sun, Yung-Nien; Ho, Chung-Liang; Hsu, Chung-Chi

2012-10-01

Physiological changes in the retinal vasculature are commonly indicative of such disorders as diabetic retinopathy, glaucoma, and age-related macular degeneration. Thus, various methods have been developed for noninvasive clinical evaluation of ocular hemodynamics. However, to the best of our knowledge, current ophthalmic instruments do not provide a true color blood flow imaging capability. Accordingly, we propose a new method for the true color imaging of blood flow using a high-speed pulsed laser photography system. In the proposed approach, monochromatic images of the blood flow are acquired using a system of three cameras and three color lasers (red, green, and blue). A high-quality true color image of the blood flow is obtained by assembling the monochromatic images by means of image realignment and color calibration processes. The effectiveness of the proposed approach is demonstrated by imaging the flow of mouse blood within a microfluidic channel device. The experimental results confirm the proposed system provides a high-quality true color blood flow imaging capability, and therefore has potential for noninvasive clinical evaluation of ocular hemodynamics.

(DURIP 10) High Speed Intensified Imaging System For Studies Of Mixing And Combustion In Supersonic Flows And Hydrocarbon Flame Structure Measurements At Elevated Pressures

DTIC Science & Technology

2016-11-09

software, and their networking to augment optical diagnostics employed in supersonic reacting and non-reacting flow experiments . A high-speed...facility at Caltech. Experiments to date have made use of this equipment, extending previous capabilities to high-speed schlieren quantitative flow...visualization and image correlation velocimetry, with further experiments currently in progress. 15. SUBJECT TERMS 16. SECURITY CLASSIFICATION OF: 17

Full range line-field parallel swept source imaging utilizing digital refocusing

NASA Astrophysics Data System (ADS)

Fechtig, Daniel J.; Kumar, Abhishek; Drexler, Wolfgang; Leitgeb, Rainer A.

2015-12-01

We present geometric optics-based refocusing applied to a novel off-axis line-field parallel swept source imaging (LPSI) system. LPSI is an imaging modality based on line-field swept source optical coherence tomography, which permits 3-D imaging at acquisition speeds of up to 1 MHz. The digital refocusing algorithm applies a defocus-correcting phase term to the Fourier representation of complex-valued interferometric image data, which is based on the geometrical optics information of the LPSI system. We introduce the off-axis LPSI system configuration, the digital refocusing algorithm and demonstrate the effectiveness of our method for refocusing volumetric images of technical and biological samples. An increase of effective in-focus depth range from 255 μm to 4.7 mm is achieved. The recovery of the full in-focus depth range might be especially valuable for future high-speed and high-resolution diagnostic applications of LPSI in ophthalmology.

Digital micromirror device based ophthalmoscope with concentric circle scanning.

PubMed

Damodaran, Mathi; Vienola, Kari V; Braaf, Boy; Vermeer, Koenraad A; de Boer, Johannes F

2017-05-01

Retinal imaging is demonstrated using a novel scanning light ophthalmoscope based on a digital micromirror device with 810 nm illumination. Concentric circles were used as scan patterns, which facilitated fixation by a human subject for imaging. An annular illumination was implemented in the system to reduce the background caused by corneal reflections and thereby to enhance the signal-to-noise ratio. A 1.9-fold increase in the signal-to-noise ratio was found by using an annular illumination aperture compared to a circular illumination aperture, resulting in a 5-fold increase in imaging speed and a better signal-to-noise ratio compared to our previous system. We tested the imaging performance of our system by performing non-mydriatic imaging on two subjects at a speed of 7 Hz with a maximum 20° (diameter) field of view. The images were shot noise limited and clearly show various anatomical features of the retina with high contrast.

Digital micromirror device based ophthalmoscope with concentric circle scanning

PubMed Central

Damodaran, Mathi; Vienola, Kari V.; Braaf, Boy; Vermeer, Koenraad A.; de Boer, Johannes F.

2017-01-01

Retinal imaging is demonstrated using a novel scanning light ophthalmoscope based on a digital micromirror device with 810 nm illumination. Concentric circles were used as scan patterns, which facilitated fixation by a human subject for imaging. An annular illumination was implemented in the system to reduce the background caused by corneal reflections and thereby to enhance the signal-to-noise ratio. A 1.9-fold increase in the signal-to-noise ratio was found by using an annular illumination aperture compared to a circular illumination aperture, resulting in a 5-fold increase in imaging speed and a better signal-to-noise ratio compared to our previous system. We tested the imaging performance of our system by performing non-mydriatic imaging on two subjects at a speed of 7 Hz with a maximum 20° (diameter) field of view. The images were shot noise limited and clearly show various anatomical features of the retina with high contrast. PMID:28663905

Standoff concealed weapon detection using a 350-GHz radar imaging system

NASA Astrophysics Data System (ADS)

Sheen, David M.; Hall, Thomas E.; Severtsen, Ronald H.; McMakin, Douglas L.; Hatchell, Brian K.; Valdez, Patrick L. J.

2010-04-01

The sub-millimeter (sub-mm) wave frequency band from 300 - 1000 GHz is currently being developed for standoff concealed weapon detection imaging applications. This frequency band is of interest due to the unique combination of high resolution and clothing penetration. The Pacific Northwest National Laboratory (PNNL) is currently developing a 350 GHz, active, wideband, three-dimensional, radar imaging system to evaluate the feasibility of active sub-mm imaging for standoff detection. Standoff concealed weapon and explosive detection is a pressing national and international need for both civilian and military security, as it may allow screening at safer distances than portal screening techniques. PNNL has developed a prototype active wideband 350 GHz radar imaging system based on a wideband, heterodyne, frequency-multiplier-based transceiver system coupled to a quasi-optical focusing system and high-speed rotating conical scanner. This prototype system operates at ranges up to 10+ meters, and can acquire an image in 10 - 20 seconds, which is fast enough to scan cooperative personnel for concealed weapons. The wideband operation of this system provides accurate ranging information, and the images obtained are fully three-dimensional. During the past year, several improvements to the system have been designed and implemented, including increased imaging speed using improved balancing techniques, wider bandwidth, and improved image processing techniques. In this paper, the imaging system is described in detail and numerous imaging results are presented.

Movement measurement of isolated skeletal muscle using imaging microscopy

NASA Astrophysics Data System (ADS)

Elias, David; Zepeda, Hugo; Leija, Lorenzo S.; Sossa, Humberto; de la Rosa, Jose I.

1997-05-01

An imaging-microscopy methodology to measure contraction movement in chemically stimulated crustacean skeletal muscle, whose movement speed is about 0.02 mm/s is presented. For this, a CCD camera coupled to a microscope and a high speed digital image acquisition system, allowing us to capture 960 images per second are used. The images are digitally processed in a PC and displayed in a video monitor. A maximal field of 0.198 X 0.198 mm2 and a spatial resolution of 3.5 micrometers are obtained.

Development of a low-cost multiple diode PIV laser for high-speed flow visualization

NASA Astrophysics Data System (ADS)

Bhakta, Raj; Hargather, Michael

2017-11-01

Particle imaging velocimetry (PIV) is an optical visualization technique that typically incorporates a single high-powered laser to illuminate seeded particles in a fluid flow. Standard PIV lasers are extremely costly and have low frequencies that severely limit its capability in high speed, time-resolved imaging. The development of a multiple diode laser system consisting of continuous lasers allows for flexible high-speed imaging with a wider range of test parameters. The developed laser system was fabricated with off-the-shelf parts for approximately 500. A series of experimental tests were conducted to compare the laser apparatus to a standard Nd:YAG double-pulsed PIV laser. Steady and unsteady flows were processed to compare the two systems and validate the accuracy of the multiple laser design. PIV results indicate good correlation between the two laser systems and verifies the construction of a precise laser instrument. The key technical obstacle to this approach was laser calibration and positioning which will be discussed. HDTRA1-14-1-0070.

High-speed imaging using 3CCD camera and multi-color LED flashes

NASA Astrophysics Data System (ADS)

Hijazi, Ala; Friedl, Alexander; Cierpka, Christian; Kähler, Christian; Madhavan, Vis

2017-11-01

This paper demonstrates the possibility of capturing full-resolution, high-speed image sequences using a regular 3CCD color camera in conjunction with high-power light emitting diodes of three different colors. This is achieved using a novel approach, referred to as spectral-shuttering, where a high-speed image sequence is captured using short duration light pulses of different colors that are sent consecutively in very close succession. The work presented in this paper demonstrates the feasibility of configuring a high-speed camera system using low cost and readily available off-the-shelf components. This camera can be used for recording six-frame sequences at frame rates up to 20 kHz or three-frame sequences at even higher frame rates. Both color crosstalk and spatial matching between the different channels of the camera are found to be within acceptable limits. A small amount of magnification difference between the different channels is found and a simple calibration procedure for correcting the images is introduced. The images captured using the approach described here are of good quality to be used for obtaining full-field quantitative information using techniques such as digital image correlation and particle image velocimetry. A sequence of six high-speed images of a bubble splash recorded at 400 Hz is presented as a demonstration.

Ultrashort Microwave-Pumped Real-Time Thermoacoustic Breast Tumor Imaging System.

PubMed

Ye, Fanghao; Ji, Zhong; Ding, Wenzheng; Lou, Cunguang; Yang, Sihua; Xing, Da

2016-03-01

We report the design of a real-time thermoacoustic (TA) scanner dedicated to imaging deep breast tumors and investigate its imaging performance. The TA imaging system is composed of an ultrashort microwave pulse generator and a ring transducer array with 384 elements. By vertically scanning the transducer array that encircles the breast phantom, we achieve real-time, 3D thermoacoustic imaging (TAI) with an imaging speed of 16.7 frames per second. The stability of the microwave energy and its distribution in the cling-skin acoustic coupling cup are measured. The results indicate that there is a nearly uniform electromagnetic field in each XY-imaging plane. Three plastic tubes filled with salt water are imaged dynamically to evaluate the real-time performance of our system, followed by 3D imaging of an excised breast tumor embedded in a breast phantom. Finally, to demonstrate the potential for clinical applications, the excised breast of a ewe embedded with an ex vivo human breast tumor is imaged clearly with a contrast of about 1:2.8. The high imaging speed, large field of view, and 3D imaging performance of our dedicated TAI system provide the potential for clinical routine breast screening.

High-speed atomic force microscopy combined with inverted optical microscopy for studying cellular events

PubMed Central

Suzuki, Yuki; Sakai, Nobuaki; Yoshida, Aiko; Uekusa, Yoshitsugu; Yagi, Akira; Imaoka, Yuka; Ito, Shuichi; Karaki, Koichi; Takeyasu, Kunio

2013-01-01

A hybrid atomic force microscopy (AFM)-optical fluorescence microscopy is a powerful tool for investigating cellular morphologies and events. However, the slow data acquisition rates of the conventional AFM unit of the hybrid system limit the visualization of structural changes during cellular events. Therefore, high-speed AFM units equipped with an optical/fluorescence detection device have been a long-standing wish. Here we describe the implementation of high-speed AFM coupled with an optical fluorescence microscope. This was accomplished by developing a tip-scanning system, instead of a sample-scanning system, which operates on an inverted optical microscope. This novel device enabled the acquisition of high-speed AFM images of morphological changes in individual cells. Using this instrument, we conducted structural studies of living HeLa and 3T3 fibroblast cell surfaces. The improved time resolution allowed us to image dynamic cellular events. PMID:23823461

High-speed atomic force microscopy combined with inverted optical microscopy for studying cellular events.

PubMed

Suzuki, Yuki; Sakai, Nobuaki; Yoshida, Aiko; Uekusa, Yoshitsugu; Yagi, Akira; Imaoka, Yuka; Ito, Shuichi; Karaki, Koichi; Takeyasu, Kunio

2013-01-01

A hybrid atomic force microscopy (AFM)-optical fluorescence microscopy is a powerful tool for investigating cellular morphologies and events. However, the slow data acquisition rates of the conventional AFM unit of the hybrid system limit the visualization of structural changes during cellular events. Therefore, high-speed AFM units equipped with an optical/fluorescence detection device have been a long-standing wish. Here we describe the implementation of high-speed AFM coupled with an optical fluorescence microscope. This was accomplished by developing a tip-scanning system, instead of a sample-scanning system, which operates on an inverted optical microscope. This novel device enabled the acquisition of high-speed AFM images of morphological changes in individual cells. Using this instrument, we conducted structural studies of living HeLa and 3T3 fibroblast cell surfaces. The improved time resolution allowed us to image dynamic cellular events.

The Power of Imaging.

ERIC Educational Resources Information Center

Haapaniemi, Peter

1990-01-01

Describes imaging technology, which allows huge numbers of words and illustrations to be reduced to tiny fraction of space required by originals and discusses current applications. Highlights include image processing system at National Archives; use by banks for high-speed check processing; engineering document management systems (EDMS); folder…

High speed real-time wavefront processing system for a solid-state laser system

NASA Astrophysics Data System (ADS)

Liu, Yuan; Yang, Ping; Chen, Shanqiu; Ma, Lifang; Xu, Bing

2008-03-01

A high speed real-time wavefront processing system for a solid-state laser beam cleanup system has been built. This system consists of a core2 Industrial PC (IPC) using Linux and real-time Linux (RT-Linux) operation system (OS), a PCI image grabber, a D/A card. More often than not, the phase aberrations of the output beam from solid-state lasers vary fast with intracavity thermal effects and environmental influence. To compensate the phase aberrations of solid-state lasers successfully, a high speed real-time wavefront processing system is presented. Compared to former systems, this system can improve the speed efficiently. In the new system, the acquisition of image data, the output of control voltage data and the implementation of reconstructor control algorithm are treated as real-time tasks in kernel-space, the display of wavefront information and man-machine conversation are treated as non real-time tasks in user-space. The parallel processing of real-time tasks in Symmetric Multi Processors (SMP) mode is the main strategy of improving the speed. In this paper, the performance and efficiency of this wavefront processing system are analyzed. The opened-loop experimental results show that the sampling frequency of this system is up to 3300Hz, and this system can well deal with phase aberrations from solid-state lasers.

A Feedfordward Adaptive Controller to Reduce the Imaging Time of Large-Sized Biological Samples with a SPM-Based Multiprobe Station

PubMed Central

Otero, Jorge; Guerrero, Hector; Gonzalez, Laura; Puig-Vidal, Manel

2012-01-01

The time required to image large samples is an important limiting factor in SPM-based systems. In multiprobe setups, especially when working with biological samples, this drawback can make impossible to conduct certain experiments. In this work, we present a feedfordward controller based on bang-bang and adaptive controls. The controls are based in the difference between the maximum speeds that can be used for imaging depending on the flatness of the sample zone. Topographic images of Escherichia coli bacteria samples were acquired using the implemented controllers. Results show that to go faster in the flat zones, rather than using a constant scanning speed for the whole image, speeds up the imaging process of large samples by up to a 4× factor. PMID:22368491

Vehicle speed detection based on gaussian mixture model using sequential of images

NASA Astrophysics Data System (ADS)

Setiyono, Budi; Ratna Sulistyaningrum, Dwi; Soetrisno; Fajriyah, Farah; Wahyu Wicaksono, Danang

2017-09-01

Intelligent Transportation System is one of the important components in the development of smart cities. Detection of vehicle speed on the highway is supporting the management of traffic engineering. The purpose of this study is to detect the speed of the moving vehicles using digital image processing. Our approach is as follows: The inputs are a sequence of frames, frame rate (fps) and ROI. The steps are following: First we separate foreground and background using Gaussian Mixture Model (GMM) in each frames. Then in each frame, we calculate the location of object and its centroid. Next we determine the speed by computing the movement of centroid in sequence of frames. In the calculation of speed, we only consider frames when the centroid is inside the predefined region of interest (ROI). Finally we transform the pixel displacement into a time unit of km/hour. Validation of the system is done by comparing the speed calculated manually and obtained by the system. The results of software testing can detect the speed of vehicles with the highest accuracy is 97.52% and the lowest accuracy is 77.41%. And the detection results of testing by using real video footage on the road is included with real speed of the vehicle.

Inspecting rapidly moving surfaces for small defects using CNN cameras

NASA Astrophysics Data System (ADS)

Blug, Andreas; Carl, Daniel; Höfler, Heinrich

2013-04-01

A continuous increase in production speed and manufacturing precision raises a demand for the automated detection of small image features on rapidly moving surfaces. An example are wire drawing processes where kilometers of cylindrical metal surfaces moving with 10 m/s have to be inspected for defects such as scratches, dents, grooves, or chatter marks with a lateral size of 100 μm in real time. Up to now, complex eddy current systems are used for quality control instead of line cameras, because the ratio between lateral feature size and surface speed is limited by the data transport between camera and computer. This bottleneck is avoided by "cellular neural network" (CNN) cameras which enable image processing directly on the camera chip. This article reports results achieved with a demonstrator based on this novel analogue camera - computer system. The results show that computational speed and accuracy of the analogue computer system are sufficient to detect and discriminate the different types of defects. Area images with 176 x 144 pixels are acquired and evaluated in real time with frame rates of 4 to 10 kHz - depending on the number of defects to be detected. These frame rates correspond to equivalent line rates on line cameras between 360 and 880 kHz, a number far beyond the available features. Using the relation between lateral feature size and surface speed as a figure of merit, the CNN based system outperforms conventional image processing systems by an order of magnitude.

Enhanced speed in fluorescence imaging using beat frequency multiplexing

NASA Astrophysics Data System (ADS)

Mikami, Hideharu; Kobayashi, Hirofumi; Wang, Yisen; Hamad, Syed; Ozeki, Yasuyuki; Goda, Keisuke

2016-03-01

Fluorescence imaging using radiofrequency-tagged emission (FIRE) is an emerging technique that enables higher imaging speed (namely, temporal resolution) in fluorescence microscopy compared to conventional fluorescence imaging techniques such as confocal microscopy and wide-field microscopy. It works based on the principle that it uses multiple intensity-modulated fields in an interferometric setup as excitation fields and applies frequency-division multiplexing to fluorescence signals. Unfortunately, despite its high potential, FIRE has limited imaging speed due to two practical limitations: signal bandwidth and signal detection efficiency. The signal bandwidth is limited by that of an acousto-optic deflector (AOD) employed in the setup, which is typically 100-200 MHz for the spectral range of fluorescence excitation (400-600 nm). The signal detection efficiency is limited by poor spatial mode-matching between two interfering fields to produce a modulated excitation field. Here we present a method to overcome these limitations and thus to achieve higher imaging speed than the prior version of FIRE. Our method achieves an increase in signal bandwidth by a factor of two and nearly optimal mode matching, which enables the imaging speed limited by the lifetime of the target fluorophore rather than the imaging system itself. The higher bandwidth and better signal detection efficiency work synergistically because higher bandwidth requires higher signal levels to avoid the contribution of shot noise and amplifier noise to the fluorescence signal. Due to its unprecedentedly high-speed performance, our method has a wide variety of applications in cancer detection, drug discovery, and regenerative medicine.

Large area high-speed metrology SPM system.

PubMed

Klapetek, P; Valtr, M; Picco, L; Payton, O D; Martinek, J; Yacoot, A; Miles, M

2015-02-13

We present a large area high-speed measuring system capable of rapidly generating nanometre resolution scanning probe microscopy data over mm(2) regions. The system combines a slow moving but accurate large area XYZ scanner with a very fast but less accurate small area XY scanner. This arrangement enables very large areas to be scanned by stitching together the small, rapidly acquired, images from the fast XY scanner while simultaneously moving the slow XYZ scanner across the region of interest. In order to successfully merge the image sequences together two software approaches for calibrating the data from the fast scanner are described. The first utilizes the low uncertainty interferometric sensors of the XYZ scanner while the second implements a genetic algorithm with multiple parameter fitting during the data merging step of the image stitching process. The basic uncertainty components related to these high-speed measurements are also discussed. Both techniques are shown to successfully enable high-resolution, large area images to be generated at least an order of magnitude faster than with a conventional atomic force microscope.

Large area high-speed metrology SPM system

NASA Astrophysics Data System (ADS)

Klapetek, P.; Valtr, M.; Picco, L.; Payton, O. D.; Martinek, J.; Yacoot, A.; Miles, M.

2015-02-01

We present a large area high-speed measuring system capable of rapidly generating nanometre resolution scanning probe microscopy data over mm2 regions. The system combines a slow moving but accurate large area XYZ scanner with a very fast but less accurate small area XY scanner. This arrangement enables very large areas to be scanned by stitching together the small, rapidly acquired, images from the fast XY scanner while simultaneously moving the slow XYZ scanner across the region of interest. In order to successfully merge the image sequences together two software approaches for calibrating the data from the fast scanner are described. The first utilizes the low uncertainty interferometric sensors of the XYZ scanner while the second implements a genetic algorithm with multiple parameter fitting during the data merging step of the image stitching process. The basic uncertainty components related to these high-speed measurements are also discussed. Both techniques are shown to successfully enable high-resolution, large area images to be generated at least an order of magnitude faster than with a conventional atomic force microscope.

Light sheet theta microscopy for rapid high-resolution imaging of large biological samples.

PubMed

Migliori, Bianca; Datta, Malika S; Dupre, Christophe; Apak, Mehmet C; Asano, Shoh; Gao, Ruixuan; Boyden, Edward S; Hermanson, Ola; Yuste, Rafael; Tomer, Raju

2018-05-29

Advances in tissue clearing and molecular labeling methods are enabling unprecedented optical access to large intact biological systems. These developments fuel the need for high-speed microscopy approaches to image large samples quantitatively and at high resolution. While light sheet microscopy (LSM), with its high planar imaging speed and low photo-bleaching, can be effective, scaling up to larger imaging volumes has been hindered by the use of orthogonal light sheet illumination. To address this fundamental limitation, we have developed light sheet theta microscopy (LSTM), which uniformly illuminates samples from the same side as the detection objective, thereby eliminating limits on lateral dimensions without sacrificing the imaging resolution, depth, and speed. We present a detailed characterization of LSTM, and demonstrate its complementary advantages over LSM for rapid high-resolution quantitative imaging of large intact samples with high uniform quality. The reported LSTM approach is a significant step for the rapid high-resolution quantitative mapping of the structure and function of very large biological systems, such as a clarified thick coronal slab of human brain and uniformly expanded tissues, and also for rapid volumetric calcium imaging of highly motile animals, such as Hydra, undergoing non-isomorphic body shape changes.

Vehicle counting system using real-time video processing

NASA Astrophysics Data System (ADS)

Crisóstomo-Romero, Pedro M.

2006-02-01

Transit studies are important for planning a road network with optimal vehicular flow. A vehicular count is essential. This article presents a vehicle counting system based on video processing. An advantage of such system is the greater detail than is possible to obtain, like shape, size and speed of vehicles. The system uses a video camera placed above the street to image transit in real-time. The video camera must be placed at least 6 meters above the street level to achieve proper acquisition quality. Fast image processing algorithms and small image dimensions are used to allow real-time processing. Digital filters, mathematical morphology, segmentation and other techniques allow identifying and counting all vehicles in the image sequences. The system was implemented under Linux in a 1.8 GHz Pentium 4 computer. A successful count was obtained with frame rates of 15 frames per second for images of size 240x180 pixels and 24 frames per second for images of size 180x120 pixels, thus being able to count vehicles whose speeds do not exceed 150 km/h.

Shear wave speed and dispersion measurements using crawling wave chirps.

PubMed

Hah, Zaegyoo; Partin, Alexander; Parker, Kevin J

2014-10-01

This article demonstrates the measurement of shear wave speed and shear speed dispersion of biomaterials using a chirp signal that launches waves over a range of frequencies. A biomaterial is vibrated by two vibration sources that generate shear waves inside the medium, which is scanned by an ultrasound imaging system. Doppler processing of the acquired signal produces an image of the square of vibration amplitude that shows repetitive constructive and destructive interference patterns called "crawling waves." With a chirp vibration signal, successive Doppler frames are generated from different source frequencies. Collected frames generate a distinctive pattern which is used to calculate the shear speed and shear speed dispersion. A special reciprocal chirp is designed such that the equi-phase lines of a motion slice image are straight lines. Detailed analysis is provided to generate a closed-form solution for calculating the shear wave speed and the dispersion. Also several phantoms and an ex vivo human liver sample are scanned and the estimation results are presented. © The Author(s) 2014.

High-speed Intravascular Photoacoustic Imaging of Lipid-laden Atherosclerotic Plaque Enabled by a 2-kHz Barium Nitrite Raman Laser

PubMed Central

Wang, Pu; Ma, Teng; Slipchenko, Mikhail N.; Liang, Shanshan; Hui, Jie; Shung, K. Kirk; Roy, Sukesh; Sturek, Michael; Zhou, Qifa; Chen, Zhongping; Cheng, Ji-Xin

2014-01-01

Lipid deposition inside the arterial wall is a key indicator of plaque vulnerability. An intravascular photoacoustic (IVPA) catheter is considered a promising device for quantifying the amount of lipid inside the arterial wall. Thus far, IVPA systems suffered from slow imaging speed (~50 s per frame) due to the lack of a suitable laser source for high-speed excitation of molecular overtone vibrations. Here, we report an improvement in IVPA imaging speed by two orders of magnitude, to 1.0 s per frame, enabled by a custom-built, 2-kHz master oscillator power amplifier (MOPA)-pumped, barium nitrite [Ba(NO3)2] Raman laser. This advancement narrows the gap in translating the IVPA technology to the clinical setting. PMID:25366991

The low-order wavefront control system for the PICTURE-C mission: high-speed image acquisition and processing

NASA Astrophysics Data System (ADS)

Hewawasam, Kuravi; Mendillo, Christopher B.; Howe, Glenn A.; Martel, Jason; Finn, Susanna C.; Cook, Timothy A.; Chakrabarti, Supriya

2017-09-01

The Planetary Imaging Concept Testbed Using a Recoverable Experiment - Coronagraph (PICTURE-C) mission will directly image debris disks and exozodiacal dust around nearby stars from a high-altitude balloon using a vector vortex coronagraph. The PICTURE-C low-order wavefront control (LOWC) system will be used to correct time-varying low-order aberrations due to pointing jitter, gravity sag, thermal deformation, and the gondola pendulum motion. We present the hardware and software implementation of the low-order ShackHartmann and reflective Lyot stop sensors. Development of the high-speed image acquisition and processing system is discussed with the emphasis on the reduction of hardware and computational latencies through the use of a real-time operating system and optimized data handling. By characterizing all of the LOWC latencies, we describe techniques to achieve a framerate of 200 Hz with a mean latency of ˜378 μs

Implementation of a high-speed face recognition system that uses an optical parallel correlator.

PubMed

Watanabe, Eriko; Kodate, Kashiko

2005-02-10

We implement a fully automatic fast face recognition system by using a 1000 frame/s optical parallel correlator designed and assembled by us. The operational speed for the 1:N (i.e., matching one image against N, where N refers to the number of images in the database) identification experiment (4000 face images) amounts to less than 1.5 s, including the preprocessing and postprocessing times. The binary real-only matched filter is devised for the sake of face recognition, and the system is optimized by the false-rejection rate (FRR) and the false-acceptance rate (FAR), according to 300 samples selected by the biometrics guideline. From trial 1:N identification experiments with the optical parallel correlator, we acquired low error rates of 2.6% FRR and 1.3% FAR. Facial images of people wearing thin glasses or heavy makeup that rendered identification difficult were identified with this system.

Integrated test system of infrared and laser data based on USB 3.0

NASA Astrophysics Data System (ADS)

Fu, Hui Quan; Tang, Lin Bo; Zhang, Chao; Zhao, Bao Jun; Li, Mao Wen

2017-07-01

Based on USB3.0, this paper presents the design method of an integrated test system for both infrared image data and laser signal data processing module. The core of the design is FPGA logic control, the design uses dual-chip DDR3 SDRAM to achieve high-speed laser data cache, and receive parallel LVDS image data through serial-to-parallel conversion chip, and it achieves high-speed data communication between the system and host computer through the USB3.0 bus. The experimental results show that the developed PC software realizes the real-time display of 14-bit LVDS original image after 14-to-8 bit conversion and JPEG2000 compressed image after decompression in software, and can realize the real-time display of the acquired laser signal data. The correctness of the test system design is verified, indicating that the interface link is normal.

Commissioning and quality assurance for VMAT delivery systems: An efficient time-resolved system using real-time EPID imaging.

PubMed

Zwan, Benjamin J; Barnes, Michael P; Hindmarsh, Jonathan; Lim, Seng B; Lovelock, Dale M; Fuangrod, Todsaporn; O'Connor, Daryl J; Keall, Paul J; Greer, Peter B

2017-08-01

An ideal commissioning and quality assurance (QA) program for Volumetric Modulated Arc Therapy (VMAT) delivery systems should assess the performance of each individual dynamic component as a function of gantry angle. Procedures within such a program should also be time-efficient, independent of the delivery system and be sensitive to all types of errors. The purpose of this work is to develop a system for automated time-resolved commissioning and QA of VMAT control systems which meets these criteria. The procedures developed within this work rely solely on images obtained, using an electronic portal imaging device (EPID) without the presence of a phantom. During the delivery of specially designed VMAT test plans, EPID frames were acquired at 9.5 Hz, using a frame grabber. The set of test plans was developed to individually assess the performance of the dose delivery and multileaf collimator (MLC) control systems under varying levels of delivery complexities. An in-house software tool was developed to automatically extract features from the EPID images and evaluate the following characteristics as a function of gantry angle: dose delivery accuracy, dose rate constancy, beam profile constancy, gantry speed constancy, dynamic MLC positioning accuracy, MLC speed and acceleration constancy, and synchronization between gantry angle, MLC positioning and dose rate. Machine log files were also acquired during each delivery and subsequently compared to information extracted from EPID image frames. The largest difference between measured and planned dose at any gantry angle was 0.8% which correlated with rapid changes in dose rate and gantry speed. For all other test plans, the dose delivered was within 0.25% of the planned dose for all gantry angles. Profile constancy was not found to vary with gantry angle for tests where gantry speed and dose rate were constant, however, for tests with varying dose rate and gantry speed, segments with lower dose rate and higher gantry speed exhibited less profile stability. MLC positional accuracy was not observed to be dependent on the degree of interdigitation. MLC speed was measured for each individual leaf and slower leaf speeds were shown to be compensated for by lower dose rates. The test procedures were found to be sensitive to 1 mm systematic MLC errors, 1 mm random MLC errors, 0.4 mm MLC gap errors and synchronization errors between the MLC, dose rate and gantry angle controls systems of 1°. In general, parameters measured by both EPID and log files agreed with the plan, however, a greater average departure from the plan was evidenced by the EPID measurements. QA test plans and analysis methods have been developed to assess the performance of each dynamic component of VMAT deliveries individually and as a function of gantry angle. This methodology relies solely on time-resolved EPID imaging without the presence of a phantom and has been shown to be sensitive to a range of delivery errors. The procedures developed in this work are both comprehensive and time-efficient and can be used for streamlined commissioning and QA of VMAT delivery systems. © 2017 American Association of Physicists in Medicine.

Non-contact rapid optical coherence elastography by high-speed 4D imaging of elastic waves

NASA Astrophysics Data System (ADS)

Song, Shaozhen; Yoon, Soon Joon; Ambroziński, Łukasz; Pelivanov, Ivan; Li, David; Gao, Liang; Shen, Tueng T.; O'Donnell, Matthew; Wang, Ruikang K.

2017-02-01

Shear wave OCE (SW-OCE) uses an OCT system to track propagating mechanical waves, providing the information needed to map the elasticity of the target sample. In this study we demonstrate high speed, 4D imaging to capture transient mechanical wave propagation. Using a high-speed Fourier domain mode-locked (FDML) swept-source OCT (SS-OCT) system operating at 1.62 MHz A-line rate, the equivalent volume rate of mechanical wave imaging is 16 kvps (kilo-volumes per second), and total imaging time for a 6 x 6 x 3 mm volume is only 0.32 s. With a displacement sensitivity of 10 nanometers, the proposed 4D imaging technique provides sufficient temporal and spatial resolution for real-time optical coherence elastography (OCE). Combined with a new air-coupled, high-frequency focused ultrasound stimulator requiring no contact or coupling media, this near real-time system can provide quantitative information on localized viscoelastic properties. SW-OCE measurements are demonstrated on tissue-mimicking phantoms and porcine cornea under various intra-ocular pressures. In addition, elasticity anisotropy in the cornea is observed. Images of the mechanical wave group velocity, which correlates with tissue elasticity, show velocities ranging from 4-20 m/s depending on pressure and propagation direction. These initial results strong suggest that 4D imaging for real-time OCE may enable high-resolution quantitative mapping of tissue biomechanical properties in clinical applications.

Simultaneous multimodal ophthalmic imaging using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography

PubMed Central

Malone, Joseph D.; El-Haddad, Mohamed T.; Bozic, Ivan; Tye, Logan A.; Majeau, Lucas; Godbout, Nicolas; Rollins, Andrew M.; Boudoux, Caroline; Joos, Karen M.; Patel, Shriji N.; Tao, Yuankai K.

2016-01-01

Scanning laser ophthalmoscopy (SLO) benefits diagnostic imaging and therapeutic guidance by allowing for high-speed en face imaging of retinal structures. When combined with optical coherence tomography (OCT), SLO enables real-time aiming and retinal tracking and provides complementary information for post-acquisition volumetric co-registration, bulk motion compensation, and averaging. However, multimodality SLO-OCT systems generally require dedicated light sources, scanners, relay optics, detectors, and additional digitization and synchronization electronics, which increase system complexity. Here, we present a multimodal ophthalmic imaging system using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography (SS-SESLO-OCT) for in vivo human retinal imaging. SESLO reduces the complexity of en face imaging systems by multiplexing spatial positions as a function of wavelength. SESLO image quality benefited from single-mode illumination and multimode collection through a prototype double-clad fiber coupler, which optimized scattered light throughput and reduce speckle contrast while maintaining lateral resolution. Using a shared 1060 nm swept-source, shared scanner and imaging optics, and a shared dual-channel high-speed digitizer, we acquired inherently co-registered en face retinal images and OCT cross-sections simultaneously at 200 frames-per-second. PMID:28101411

A Flexible Annular-Array Imaging Platform for Micro-Ultrasound

PubMed Central

Qiu, Weibao; Yu, Yanyan; Chabok, Hamid Reza; Liu, Cheng; Tsang, Fu Keung; Zhou, Qifa; Shung, K. Kirk; Zheng, Hairong; Sun, Lei

2013-01-01

Micro-ultrasound is an invaluable imaging tool for many clinical and preclinical applications requiring high resolution (approximately several tens of micrometers). Imaging systems for micro-ultrasound, including single-element imaging systems and linear-array imaging systems, have been developed extensively in recent years. Single-element systems are cheaper, but linear-array systems give much better image quality at a higher expense. Annular-array-based systems provide a third alternative, striking a balance between image quality and expense. This paper presents the development of a novel programmable and real-time annular-array imaging platform for micro-ultrasound. It supports multi-channel dynamic beamforming techniques for large-depth-of-field imaging. The major image processing algorithms were achieved by a novel field-programmable gate array technology for high speed and flexibility. Real-time imaging was achieved by fast processing algorithms and high-speed data transfer interface. The platform utilizes a printed circuit board scheme incorporating state-of-the-art electronics for compactness and cost effectiveness. Extensive tests including hardware, algorithms, wire phantom, and tissue mimicking phantom measurements were conducted to demonstrate good performance of the platform. The calculated contrast-to-noise ratio (CNR) of the tissue phantom measurements were higher than 1.2 in the range of 3.8 to 8.7 mm imaging depth. The platform supported more than 25 images per second for real-time image acquisition. The depth-of-field had about 2.5-fold improvement compared to single-element transducer imaging. PMID:23287923

Exploring microwave resonant multi-point ignition using high-speed schlieren imaging

NASA Astrophysics Data System (ADS)

Liu, Cheng; Zhang, Guixin; Xie, Hong; Deng, Lei; Wang, Zhi

2018-03-01

Microwave plasma offers a potential method to achieve rapid combustion in a high-speed combustor. In this paper, microwave resonant multi-point ignition and its control method have been studied via high-speed schlieren imaging. The experiment was conducted with the microwave resonant ignition system and the schlieren optical system. The microwave pulse in 2.45 GHz with 2 ms width and 3 kW peak power was employed as an ignition energy source to produce initial flame kernels in the combustion chamber. A reflective schlieren method was designed to illustrate the flame development process with a high-speed camera. The bottom of the combustion chamber was made of a quartz glass coated with indium tin oxide, which ensures sufficient microwave reflection and light penetration. Ignition experiments were conducted at 2 bars of stoichiometric methane-air mixtures. Schlieren images show that flame kernels were generated at more than one location simultaneously and flame propagated with different speeds in different flame kernels. Ignition kernels were discussed in three types according to their appearances. Pressure curves and combustion duration also show that multi-point ignition plays a significant role in accelerating combustion.

Digitally controlled analog proportional-integral-derivative (PID) controller for high-speed scanning probe microscopy

NASA Astrophysics Data System (ADS)

Dukic, Maja; Todorov, Vencislav; Andany, Santiago; Nievergelt, Adrian P.; Yang, Chen; Hosseini, Nahid; Fantner, Georg E.

2017-12-01

Nearly all scanning probe microscopes (SPMs) contain a feedback controller, which is used to move the scanner in the direction of the z-axis in order to maintain a constant setpoint based on the tip-sample interaction. The most frequently used feedback controller in SPMs is the proportional-integral (PI) controller. The bandwidth of the PI controller presents one of the speed limiting factors in high-speed SPMs, where higher bandwidths enable faster scanning speeds and higher imaging resolution. Most SPM systems use digital signal processor-based PI feedback controllers, which require analog-to-digital and digital-to-analog converters. These converters introduce additional feedback delays which limit the achievable imaging speed and resolution. In this paper, we present a digitally controlled analog proportional-integral-derivative (PID) controller. The controller implementation allows tunability of the PID gains over a large amplification and frequency range, while also providing precise control of the system and reproducibility of the gain parameters. By using the analog PID controller, we were able to perform successful atomic force microscopy imaging of a standard silicon calibration grating at line rates up to several kHz.

Digitally controlled analog proportional-integral-derivative (PID) controller for high-speed scanning probe microscopy.

PubMed

Dukic, Maja; Todorov, Vencislav; Andany, Santiago; Nievergelt, Adrian P; Yang, Chen; Hosseini, Nahid; Fantner, Georg E

2017-12-01

Nearly all scanning probe microscopes (SPMs) contain a feedback controller, which is used to move the scanner in the direction of the z-axis in order to maintain a constant setpoint based on the tip-sample interaction. The most frequently used feedback controller in SPMs is the proportional-integral (PI) controller. The bandwidth of the PI controller presents one of the speed limiting factors in high-speed SPMs, where higher bandwidths enable faster scanning speeds and higher imaging resolution. Most SPM systems use digital signal processor-based PI feedback controllers, which require analog-to-digital and digital-to-analog converters. These converters introduce additional feedback delays which limit the achievable imaging speed and resolution. In this paper, we present a digitally controlled analog proportional-integral-derivative (PID) controller. The controller implementation allows tunability of the PID gains over a large amplification and frequency range, while also providing precise control of the system and reproducibility of the gain parameters. By using the analog PID controller, we were able to perform successful atomic force microscopy imaging of a standard silicon calibration grating at line rates up to several kHz.

Exploring microwave resonant multi-point ignition using high-speed schlieren imaging.

PubMed

Liu, Cheng; Zhang, Guixin; Xie, Hong; Deng, Lei; Wang, Zhi

2018-03-01

Microwave plasma offers a potential method to achieve rapid combustion in a high-speed combustor. In this paper, microwave resonant multi-point ignition and its control method have been studied via high-speed schlieren imaging. The experiment was conducted with the microwave resonant ignition system and the schlieren optical system. The microwave pulse in 2.45 GHz with 2 ms width and 3 kW peak power was employed as an ignition energy source to produce initial flame kernels in the combustion chamber. A reflective schlieren method was designed to illustrate the flame development process with a high-speed camera. The bottom of the combustion chamber was made of a quartz glass coated with indium tin oxide, which ensures sufficient microwave reflection and light penetration. Ignition experiments were conducted at 2 bars of stoichiometric methane-air mixtures. Schlieren images show that flame kernels were generated at more than one location simultaneously and flame propagated with different speeds in different flame kernels. Ignition kernels were discussed in three types according to their appearances. Pressure curves and combustion duration also show that multi-point ignition plays a significant role in accelerating combustion.

Calcium imaging of neural circuits with extended depth-of-field light-sheet microscopy

PubMed Central

Quirin, Sean; Vladimirov, Nikita; Yang, Chao-Tsung; Peterka, Darcy S.; Yuste, Rafael; Ahrens, Misha B.

2016-01-01

Increasing the volumetric imaging speed of light-sheet microscopy will improve its ability to detect fast changes in neural activity. Here, a system is introduced for brain-wide imaging of neural activity in the larval zebrafish by coupling structured illumination with cubic phase extended depth-of-field (EDoF) pupil encoding. This microscope enables faster light-sheet imaging and facilitates arbitrary plane scanning—removing constraints on acquisition speed, alignment tolerances, and physical motion near the sample. The usefulness of this method is demonstrated by performing multi-plane calcium imaging in the fish brain with a 416 × 832 × 160 µm field of view at 33 Hz. The optomotor response behavior of the zebrafish is monitored at high speeds, and time-locked correlations of neuronal activity are resolved across its brain. PMID:26974063

A high-speed network for cardiac image review.

PubMed

Elion, J L; Petrocelli, R R

1994-01-01

A high-speed fiber-based network for the transmission and display of digitized full-motion cardiac images has been developed. Based on Asynchronous Transfer Mode (ATM), the network is scaleable, meaning that the same software and hardware is used for a small local area network or for a large multi-institutional network. The system can handle uncompressed digital angiographic images, considered to be at the "high-end" of the bandwidth requirements. Along with the networking, a general-purpose multi-modality review station has been implemented without specialized hardware. This station can store a full injection sequence in "loop RAM" in a 512 x 512 format, then interpolate to 1024 x 1024 while displaying at 30 frames per second. The network and review stations connect to a central file server that uses a virtual file system to make a large high-speed RAID storage disk and associated off-line storage tapes and cartridges all appear as a single large file system to the software. In addition to supporting archival storage and review, the system can also digitize live video using high-speed Direct Memory Access (DMA) from the frame grabber to present uncompressed data to the network. Fully functional prototypes have provided the proof of concept, with full deployment in the institution planned as the next stage.

A high-speed network for cardiac image review.

PubMed Central

Elion, J. L.; Petrocelli, R. R.

1994-01-01

A high-speed fiber-based network for the transmission and display of digitized full-motion cardiac images has been developed. Based on Asynchronous Transfer Mode (ATM), the network is scaleable, meaning that the same software and hardware is used for a small local area network or for a large multi-institutional network. The system can handle uncompressed digital angiographic images, considered to be at the "high-end" of the bandwidth requirements. Along with the networking, a general-purpose multi-modality review station has been implemented without specialized hardware. This station can store a full injection sequence in "loop RAM" in a 512 x 512 format, then interpolate to 1024 x 1024 while displaying at 30 frames per second. The network and review stations connect to a central file server that uses a virtual file system to make a large high-speed RAID storage disk and associated off-line storage tapes and cartridges all appear as a single large file system to the software. In addition to supporting archival storage and review, the system can also digitize live video using high-speed Direct Memory Access (DMA) from the frame grabber to present uncompressed data to the network. Fully functional prototypes have provided the proof of concept, with full deployment in the institution planned as the next stage. PMID:7949964

Fuzzy Logic Enhanced Digital PIV Processing Software

NASA Technical Reports Server (NTRS)

Wernet, Mark P.

1999-01-01

Digital Particle Image Velocimetry (DPIV) is an instantaneous, planar velocity measurement technique that is ideally suited for studying transient flow phenomena in high speed turbomachinery. DPIV is being actively used at the NASA Glenn Research Center to study both stable and unstable operating conditions in a high speed centrifugal compressor. Commercial PIV systems are readily available which provide near real time feedback of the PIV image data quality. These commercial systems are well designed to facilitate the expedient acquisition of PIV image data. However, as with any general purpose system, these commercial PIV systems do not meet all of the data processing needs required for PIV image data reduction in our compressor research program. An in-house PIV PROCessing (PIVPROC) code has been developed for reducing PIV data. The PIVPROC software incorporates fuzzy logic data validation for maximum information recovery from PIV image data. PIVPROC enables combined cross-correlation/particle tracking wherein the highest possible spatial resolution velocity measurements are obtained.

Walking modulates speed sensitivity in Drosophila motion vision.

PubMed

Chiappe, M Eugenia; Seelig, Johannes D; Reiser, Michael B; Jayaraman, Vivek

2010-08-24

Changes in behavioral state modify neural activity in many systems. In some vertebrates such modulation has been observed and interpreted in the context of attention and sensorimotor coordinate transformations. Here we report state-dependent activity modulations during walking in a visual-motor pathway of Drosophila. We used two-photon imaging to monitor intracellular calcium activity in motion-sensitive lobula plate tangential cells (LPTCs) in head-fixed Drosophila walking on an air-supported ball. Cells of the horizontal system (HS)--a subgroup of LPTCs--showed stronger calcium transients in response to visual motion when flies were walking rather than resting. The amplified responses were also correlated with walking speed. Moreover, HS neurons showed a relatively higher gain in response strength at higher temporal frequencies, and their optimum temporal frequency was shifted toward higher motion speeds. Walking-dependent modulation of HS neurons in the Drosophila visual system may constitute a mechanism to facilitate processing of higher image speeds in behavioral contexts where these speeds of visual motion are relevant for course stabilization. Copyright 2010 Elsevier Ltd. All rights reserved.

Implementation of an RBF neural network on embedded systems: real-time face tracking and identity verification.

PubMed

Yang, Fan; Paindavoine, M

2003-01-01

This paper describes a real time vision system that allows us to localize faces in video sequences and verify their identity. These processes are image processing techniques based on the radial basis function (RBF) neural network approach. The robustness of this system has been evaluated quantitatively on eight video sequences. We have adapted our model for an application of face recognition using the Olivetti Research Laboratory (ORL), Cambridge, UK, database so as to compare the performance against other systems. We also describe three hardware implementations of our model on embedded systems based on the field programmable gate array (FPGA), zero instruction set computer (ZISC) chips, and digital signal processor (DSP) TMS320C62, respectively. We analyze the algorithm complexity and present results of hardware implementations in terms of the resources used and processing speed. The success rates of face tracking and identity verification are 92% (FPGA), 85% (ZISC), and 98.2% (DSP), respectively. For the three embedded systems, the processing speeds for images size of 288 /spl times/ 352 are 14 images/s, 25 images/s, and 4.8 images/s, respectively.

WE-DE-BRA-09: Fast Megavoltage CT Imaging with Rapid Scan Time and Low Imaging Dose in Helical Tomotherapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Magome, T; University of Tokyo Hospital, Tokyo; University of Minnesota, Minneapolis, MN

Purpose: Megavoltage computed tomography (MVCT) imaging has been widely used for daily patient setup with helical tomotherapy (HT). One drawback of MVCT is its very long imaging time, owing to slow couch speed. The purpose of this study was to develop an MVCT imaging method allowing faster couch speeds, and to assess its accuracy for image guidance for HT. Methods: Three cadavers (mimicking closest physiological and physical system of patients) were scanned four times with couch speeds of 1, 2, 3, and 4 mm/s. The resulting MVCT images were reconstructed using an iterative reconstruction (IR) algorithm. The MVCT images weremore » registered with kilovoltage CT images, and the registration errors were compared with the errors with conventional filtered back projection (FBP) algorithm. Moreover, the fast MVCT imaging was tested in three cases of total marrow irradiation as a clinical trial. Results: Three-dimensional registration errors of the MVCT images reconstructed with the IR algorithm were significantly smaller (p < 0.05) than the errors of images reconstructed with the FBP algorithm at fast couch speeds (3, 4 mm/s). The scan time and imaging dose at a speed of 4 mm/s were reduced to 30% of those from a conventional coarse mode scan. For the patient imaging, a limited number of conventional MVCT (1.2 mm/s) and fast MVCT (3 mm/s) reveals acceptable reduced imaging time and dose able to use for anatomical registration. Conclusion: Fast MVCT with IR algorithm maybe clinically feasible alternative for rapid 3D patient localization. This technique may also be useful for calculating daily dose distributions or organ motion analyses in HT treatment over a wide area.« less

Visualization of hair follicles using high-speed optical coherence tomography based on a Fourier domain mode locking laser

NASA Astrophysics Data System (ADS)

Tsai, M.-T.; Chang, F.-Y.

2012-04-01

In this study, a swept-source optical coherence tomography (SS-OCT) system with a Fourier domain mode locking (FDML) laser is proposed for a dermatology study. The homemade FDML laser is one kind of frequency-sweeping light source, which can provide output power of >20 mW and an output spectrum of 65 nm in bandwidth centered at 1300 nm, enabling imaging with an axial resolution of 12 μm in the OCT system. To eliminate the forward scans from the laser output and insert the delayed backward scans, a Mach-Zehnder configuration is implemented. Compared with conventional frequency-sweeping light sources, the FDML laser can achieve much higher scan rates, as high as ˜240 kHz, which can provide a three-dimensional imaging rate of 4 volumes/s. Furthermore, the proposed high-speed SS-OCT system can provide three-dimensional (3D) images with reduced motion artifacts. Finally, a high-speed SS-OCT system is used to visualize hair follicles, demonstrating the potential of this technology as a tool for noninvasive diagnosis of alopecia.

Turbulent Mixing and Combustion for High-Speed Air-Breathing Propulsion Application

DTIC Science & Technology

2007-08-12

deficit (the velocity of the wake relative to the free-stream velocity), decays rapidly with downstream distance, so that the streamwise velocity is...switched laser with double-pulse option) and a new imaging system (high-resolution: 4008x2672 pix2, low- noise (cooled) Cooke PCO-4000 CCD camera). The...was designed in-house for high-speed low- noise image acquisition. The KFS CCD image sensor was designed by Mark Wadsworth of JPL and has a resolution

High-resolution retinal imaging using adaptive optics and Fourier-domain optical coherence tomography

DOEpatents

Olivier, Scot S.; Werner, John S.; Zawadzki, Robert J.; Laut, Sophie P.; Jones, Steven M.

2010-09-07

This invention permits retinal images to be acquired at high speed and with unprecedented resolution in three dimensions (4.times.4.times.6 .mu.m). The instrument achieves high lateral resolution by using adaptive optics to correct optical aberrations of the human eye in real time. High axial resolution and high speed are made possible by the use of Fourier-domain optical coherence tomography. Using this system, we have demonstrated the ability to image microscopic blood vessels and the cone photoreceptor mosaic.

Development of a prototype sensor system for ultra-high-speed LDA-PIV

NASA Astrophysics Data System (ADS)

Griffiths, Jennifer A.; Royle, Gary J.; Bohndiek, Sarah E.; Turchetta, Renato; Chen, Daoyi

2008-04-01

Laser Doppler Anemometry (LDA) and Particle Image Velocimetry (PIV) are commonly used in the analysis of particulates in fluid flows. Despite the successes of these techniques, current instrumentation has placed limitations on the size and shape of the particles undergoing measurement, thus restricting the available data for the many industrial processes now utilising nano/micro particles. Data for spherical and irregularly shaped particles down to the order of 0.1 µm is now urgently required. Therefore, an ultra-fast LDA-PIV system is being constructed for the acquisition of this data. A key component of this instrument is the PIV optical detection system. Both the size and speed of the particles under investigation place challenging constraints on the system specifications: magnification is required within the system in order to visualise particles of the size of interest, but this restricts the corresponding field of view in a linearly inverse manner. Thus, for several images of a single particle in a fast fluid flow to be obtained, the image capture rate and sensitivity of the system must be sufficiently high. In order to fulfil the instrumentation criteria, the optical detection system chosen is a high-speed, lensed, digital imaging system based on state-of-the-art CMOS technology - the 'Vanilla' sensor developed by the UK based MI3 consortium. This novel Active Pixel Sensor is capable of high frame rates and sparse readout. When coupled with an image intensifier, it will have single photon detection capabilities. An FPGA based DAQ will allow real-time operation with minimal data transfer.

Interferometric inverse synthetic aperture radar imaging for space targets based on wideband direct sampling using two antennas

NASA Astrophysics Data System (ADS)

Tian, Biao; Liu, Yang; Xu, Shiyou; Chen, Zengping

2014-01-01

Interferometric inverse synthetic aperture radar (InISAR) imaging provides complementary information to monostatic inverse synthetic aperture radar (ISAR) imaging. This paper proposes a new InISAR imaging system for space targets based on wideband direct sampling using two antennas. The system is easy to realize in engineering since the motion trajectory of space targets can be known in advance, which is simpler than that of three receivers. In the preprocessing step, high speed movement compensation is carried out by designing an adaptive matched filter containing speed that is obtained from the narrow band information. Then, the coherent processing and keystone transform for ISAR imaging are adopted to reserve the phase history of each antenna. Through appropriate collocation of the system, image registration and phase unwrapping can be avoided. Considering the situation not to be satisfied, the influence of baseline variance is analyzed and compensation method is adopted. The corresponding size can be achieved by interferometric processing of the two complex ISAR images. Experimental results prove the validity of the analysis and the three-dimensional imaging algorithm.

High speed CMOS acquisition system based on FPGA embedded image processing for electro-optical measurements

NASA Astrophysics Data System (ADS)

Rosu-Hamzescu, Mihnea; Polonschii, Cristina; Oprea, Sergiu; Popescu, Dragos; David, Sorin; Bratu, Dumitru; Gheorghiu, Eugen

2018-06-01

Electro-optical measurements, i.e., optical waveguides and plasmonic based electrochemical impedance spectroscopy (P-EIS), are based on the sensitive dependence of refractive index of electro-optical sensors on surface charge density, modulated by an AC electrical field applied to the sensor surface. Recently, P-EIS has emerged as a new analytical tool that can resolve local impedance with high, optical spatial resolution, without using microelectrodes. This study describes a high speed image acquisition and processing system for electro-optical measurements, based on a high speed complementary metal-oxide semiconductor (CMOS) sensor and a field-programmable gate array (FPGA) board. The FPGA is used to configure CMOS parameters, as well as to receive and locally process the acquired images by performing Fourier analysis for each pixel, deriving the real and imaginary parts of the Fourier coefficients for the AC field frequencies. An AC field generator, for single or multi-sine signals, is synchronized with the high speed acquisition system for phase measurements. The system was successfully used for real-time angle-resolved electro-plasmonic measurements from 30 Hz up to 10 kHz, providing results consistent to ones obtained by a conventional electrical impedance approach. The system was able to detect amplitude variations with a relative variation of ±1%, even for rather low sampling rates per period (i.e., 8 samples per period). The PC (personal computer) acquisition and control software allows synchronized acquisition for multiple FPGA boards, making it also suitable for simultaneous angle-resolved P-EIS imaging.

Design of noise barrier inspection system for high-speed railway

NASA Astrophysics Data System (ADS)

Liu, Bingqian; Shao, Shuangyun; Feng, Qibo; Ma, Le; Cholryong, Kim

2016-10-01

The damage of noise barriers will highly reduce the transportation safety of the high-speed railway. In this paper, an online inspection system of noise barrier based on laser vision for the safety of high-speed railway is proposed. The inspection system, mainly consisted of a fast camera and a line laser, installed in the first carriage of the high-speed CIT(Composited Inspection Train).A Laser line was projected on the surface of the noise barriers and the images of the light line were received by the camera while the train is running at high speed. The distance between the inspection system and the noise barrier can be obtained based on laser triangulation principle. The results of field tests show that the proposed system can meet the need of high speed and high accuracy to get the contour distortion of the noise barriers.

A portable high-speed camera system for vocal fold examinations.

PubMed

Hertegård, Stellan; Larsson, Hans

2014-11-01

In this article, we present a new portable low-cost system for high-speed examinations of the vocal folds. Analysis of glottal vibratory parameters from the high-speed recordings is compared with videostroboscopic recordings. The high-speed system is built around a Fastec 1 monochrome camera, which is used with newly developed software, High-Speed Studio (HSS). The HSS has options for video/image recording, contains a database, and has a set of analysis options. The Fastec/HSS system has been used clinically since 2011 in more than 2000 patient examinations and recordings. The Fastec 1 camera has sufficient time resolution (≥4000 frames/s) and light sensitivity (ISO 3200) to produce images for detailed analyses of parameters pertinent to vocal fold function. The camera can be used with both rigid and flexible endoscopes. The HSS software includes options for analyses of glottal vibrations, such as kymogram, phase asymmetry, glottal area variation, open and closed phase, and angle of vocal fold abduction. It can also be used for separate analysis of the left and vocal fold movements, including maximum speed during opening and closing, a parameter possibly related to vocal fold elasticity. A blinded analysis of 32 patients with various voice disorders examined with both the Fastec/HSS system and videostroboscopy showed that the high-speed recordings were significantly better for the analysis of glottal parameters (eg, mucosal wave and vibration asymmetry). The monochrome high-speed system can be used in daily clinical work within normal clinical time limits for patient examinations. A detailed analysis can be made of voice disorders and laryngeal pathology at a relatively low cost. Copyright © 2014 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

Synchronous high speed multi-point velocity profile measurement by heterodyne interferometry

NASA Astrophysics Data System (ADS)

Hou, Xueqin; Xiao, Wen; Chen, Zonghui; Qin, Xiaodong; Pan, Feng

2017-02-01

This paper presents a synchronous multipoint velocity profile measurement system, which acquires the vibration velocities as well as images of vibrating objects by combining optical heterodyne interferometry and a high-speed CMOS-DVR camera. The high-speed CMOS-DVR camera records a sequence of images of the vibrating object. Then, by extracting and processing multiple pixels at the same time, a digital demodulation technique is implemented to simultaneously acquire the vibrating velocity of the target from the recorded sequences of images. This method is validated with an experiment. A piezoelectric ceramic plate with standard vibration characteristics is used as the vibrating target, which is driven by a standard sinusoidal signal.

TH-CD-207B-03: How to Quantify Temporal Resolution in X-Ray MDCT Imaging?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Budde, A; GE Healthcare Technologies, Madison, WI; Li, Y

Purpose: In modern CT scanners, a quantitative metric to assess temporal response, namely, to quantify the temporal resolution (TR), remains elusive. Rough surrogate metrics, such as half of the gantry rotation time for single source CT, a quarter of the gantry rotation time for dual source CT, or measurements of motion artifact’s size, shape, or intensity have previously been used. In this work, a rigorous framework which quantifies TR and a practical measurement method are developed. Methods: A motion phantom was simulated which consisted of a single rod that is in motion except during a static period at the temporalmore » center of the scan, termed the TR window. If the image of the motion scan has negligible motion artifacts compared to an image from a totally static scan, then the system has a TR no worse than the TR window used. By repeating this comparison with varying TR windows, the TR of the system can be accurately determined. Motion artifacts were also visually assessed and the TR was measured across varying rod motion speeds, directions, and locations. Noiseless fan beam acquisitions were simulated and images were reconstructed with a short-scan image reconstruction algorithm. Results: The size, shape, and intensity of motion artifacts varied when the rod speed, direction, or location changed. TR measured using the proposed method, however, was consistent across rod speeds, directions, and locations. Conclusion: Since motion artifacts vary depending upon the motion speed, direction, and location, they are not suitable for measuring TR. In this work, a CT system with a specified TR is defined as having the ability to produce a static image with negligible motion artifacts, no matter what motion occurs outside of a static window of width TR. This framework allows for practical measurement of temporal resolution in clinical CT imaging systems. Funding support: GE Healthcare; Conflict of Interest: Employee, GE Healthcare.« less

High Speed Digital Camera Technology Review

NASA Technical Reports Server (NTRS)

Clements, Sandra D.

2009-01-01

A High Speed Digital Camera Technology Review (HSD Review) is being conducted to evaluate the state-of-the-shelf in this rapidly progressing industry. Five HSD cameras supplied by four camera manufacturers participated in a Field Test during the Space Shuttle Discovery STS-128 launch. Each camera was also subjected to Bench Tests in the ASRC Imaging Development Laboratory. Evaluation of the data from the Field and Bench Tests is underway. Representatives from the imaging communities at NASA / KSC and the Optical Systems Group are participating as reviewers. A High Speed Digital Video Camera Draft Specification was updated to address Shuttle engineering imagery requirements based on findings from this HSD Review. This draft specification will serve as the template for a High Speed Digital Video Camera Specification to be developed for the wider OSG imaging community under OSG Task OS-33.

High-speed large angle mammography tomosynthesis system

NASA Astrophysics Data System (ADS)

Eberhard, Jeffrey W.; Staudinger, Paul; Smolenski, Joe; Ding, Jason; Schmitz, Andrea; McCoy, Julie; Rumsey, Michael; Al-Khalidy, Abdulrahman; Ross, William; Landberg, Cynthia E.; Claus, Bernhard E. H.; Carson, Paul; Goodsitt, Mitchell; Chan, Heang-Ping; Roubidoux, Marilyn; Thomas, Jerry A.; Osland, Jacqueline

2006-03-01

A new mammography tomosynthesis prototype system that acquires 21 projection images over a 60 degree angular range in approximately 8 seconds has been developed and characterized. Fast imaging sequences are facilitated by a high power tube and generator for faster delivery of the x-ray exposure and a high speed detector read-out. An enhanced a-Si/CsI flat panel digital detector provides greater DQE at low exposure, enabling tomo image sequence acquisitions at total patient dose levels between 150% and 200% of the dose of a standard mammographic view. For clinical scenarios where a single MLO tomographic acquisition per breast may replace the standard CC and MLO views, total tomosynthesis breast dose is comparable to or below the dose in standard mammography. The system supports co-registered acquisition of x-ray tomosynthesis and 3-D ultrasound data sets by incorporating an ultrasound transducer scanning system that flips into position above the compression paddle for the ultrasound exam. Initial images acquired with the system are presented.

Intraoperative video-rate hemodynamic response assessment in human cortex using snapshot hyperspectral optical imaging

PubMed Central

Pichette, Julien; Laurence, Audrey; Angulo, Leticia; Lesage, Frederic; Bouthillier, Alain; Nguyen, Dang Khoa; Leblond, Frederic

2016-01-01

Abstract. Using light, we are able to visualize the hemodynamic behavior of the brain to better understand neurovascular coupling and cerebral metabolism. In vivo optical imaging of tissue using endogenous chromophores necessitates spectroscopic detection to ensure molecular specificity as well as sufficiently high imaging speed and signal-to-noise ratio, to allow dynamic physiological changes to be captured, isolated, and used as surrogate of pathophysiological processes. An optical imaging system is introduced using a 16-bands on-chip hyperspectral camera. Using this system, we show that up to three dyes can be imaged and quantified in a tissue phantom at video-rate through the optics of a surgical microscope. In vivo human patient data are presented demonstrating brain hemodynamic response can be measured intraoperatively with molecular specificity at high speed. PMID:27752519

NRL Fact Book 2010

DTIC Science & Technology

2010-01-01

service) High assurance software Distributed network-based battle management High performance computing supporting uniform and nonuniform memory...VNIR, MWIR, and LWIR high-resolution systems Wideband SAR systems RF and laser data links High-speed, high-power photodetector characteriza- tion...Antimonide (InSb) imaging system Long-wave infrared ( LWIR ) quantum well IR photodetector (QWIP) imaging system Research and Development Services

Ultrahigh speed endoscopic swept source optical coherence tomography using a VCSEL light source and micromotor catheter

NASA Astrophysics Data System (ADS)

Tsai, Tsung-Han; Ahsen, Osman O.; Lee, Hsiang-Chieh; Liang, Kaicheng; Giacomelli, Michael G.; Potsaid, Benjamin M.; Tao, Yuankai K.; Jayaraman, Vijaysekhar; Kraus, Martin F.; Hornegger, Joachim; Figueiredo, Marisa; Huang, Qin; Mashimo, Hiroshi; Cable, Alex E.; Fujimoto, James G.

2014-03-01

We developed an ultrahigh speed endoscopic swept source optical coherence tomography (OCT) system for clinical gastroenterology using a vertical-cavity surface-emitting laser (VCSEL) and micromotor based imaging catheter, which provided an imaging speed of 600 kHz axial scan rate and 8 μm axial resolution in tissue. The micromotor catheter was 3.2 mm in diameter and could be introduced through the 3.7 mm accessory port of an endoscope. Imaging was performed at 400 frames per second with an 8 μm spot size using a pullback to generate volumetric data over 16 mm with a pixel spacing of 5 μm in the longitudinal direction. Three-dimensional OCT (3D-OCT) imaging was performed in patients with a cross section of pathologies undergoing standard upper and lower endoscopy at the Veterans Affairs Boston Healthcare System (VABHS). Patients with Barrett's esophagus, dysplasia, and inflammatory bowel disease were imaged. The use of distally actuated imaging catheters allowed OCT imaging with more flexibility such as volumetric imaging in the terminal ileum and the assessment of the hiatal hernia using retroflex imaging. The high rotational stability of the micromotor enabled 3D volumetric imaging with micron scale volumetric accuracy for both en face and cross-sectional imaging. The ability to perform 3D OCT imaging in the GI tract with microscopic accuracy should enable a wide range of studies to investigate the ability of OCT to detect pathology as well as assess treatment response.

Image processing system design for microcantilever-based optical readout infrared arrays

NASA Astrophysics Data System (ADS)

Tong, Qiang; Dong, Liquan; Zhao, Yuejin; Gong, Cheng; Liu, Xiaohua; Yu, Xiaomei; Yang, Lei; Liu, Weiyu

2012-12-01

Compared with the traditional infrared imaging technology, the new type of optical-readout uncooled infrared imaging technology based on MEMS has many advantages, such as low cost, small size, producing simple. In addition, the theory proves that the technology's high thermal detection sensitivity. So it has a very broad application prospects in the field of high performance infrared detection. The paper mainly focuses on an image capturing and processing system in the new type of optical-readout uncooled infrared imaging technology based on MEMS. The image capturing and processing system consists of software and hardware. We build our image processing core hardware platform based on TI's high performance DSP chip which is the TMS320DM642, and then design our image capturing board based on the MT9P031. MT9P031 is Micron's company high frame rate, low power consumption CMOS chip. Last we use Intel's company network transceiver devices-LXT971A to design the network output board. The software system is built on the real-time operating system DSP/BIOS. We design our video capture driver program based on TI's class-mini driver and network output program based on the NDK kit for image capturing and processing and transmitting. The experiment shows that the system has the advantages of high capturing resolution and fast processing speed. The speed of the network transmission is up to 100Mbps.

Naval Research Laboratory Fact Book 2012

DTIC Science & Technology

2012-11-01

Distributed network-based battle management High performance computing supporting uniform and nonuniform memory access with single and multithreaded...hyperspectral systems VNIR, MWIR, and LWIR high-resolution systems Wideband SAR systems RF and laser data links High-speed, high-power...hyperspectral imaging system Long-wave infrared ( LWIR ) quantum well IR photodetector (QWIP) imaging system Research and Development Services Divi- sion

A Simulation Model Of A Picture Archival And Communication System

NASA Astrophysics Data System (ADS)

D'Silva, Vijay; Perros, Harry; Stockbridge, Chris

1988-06-01

A PACS architecture was simulated to quantify its performance. The model consisted of reading stations, acquisition nodes, communication links, a database management system, and a storage system consisting of magnetic and optical disks. Two levels of storage were simulated, a high-speed magnetic disk system for short term storage, and optical disk jukeboxes for long term storage. The communications link was a single bus via which image data were requested and delivered. Real input data to the simulation model were obtained from surveys of radiology procedures (Bowman Gray School of Medicine). From these the following inputs were calculated: - the size of short term storage necessary - the amount of long term storage required - the frequency of access of each store, and - the distribution of the number of films requested per diagnosis. The performance measures obtained were - the mean retrieval time for an image, - mean queue lengths, and - the utilization of each device. Parametric analysis was done for - the bus speed, - the packet size for the communications link, - the record size on the magnetic disk, - compression ratio, - influx of new images, - DBMS time, and - diagnosis think times. Plots give the optimum values for those values of input speed and device performance which are sufficient to achieve subsecond image retrieval times

Development of Neuromorphic Sift Operator with Application to High Speed Image Matching

NASA Astrophysics Data System (ADS)

Shankayi, M.; Saadatseresht, M.; Bitetto, M. A. V.

2015-12-01

There was always a speed/accuracy challenge in photogrammetric mapping process, including feature detection and matching. Most of the researches have improved algorithm's speed with simplifications or software modifications which increase the accuracy of the image matching process. This research tries to improve speed without enhancing the accuracy of the same algorithm using Neuromorphic techniques. In this research we have developed a general design of a Neuromorphic ASIC to handle algorithms such as SIFT. We also have investigated neural assignment in each step of the SIFT algorithm. With a rough estimation based on delay of the used elements including MAC and comparator, we have estimated the resulting chip's performance for 3 scenarios, Full HD movie (Videogrammetry), 24 MP (UAV photogrammetry), and 88 MP image sequence. Our estimations led to approximate 3000 fps for Full HD movie, 250 fps for 24 MP image sequence and 68 fps for 88MP Ultracam image sequence which can be a huge improvement for current photogrammetric processing systems. We also estimated the power consumption of less than10 watts which is not comparable to current workflows.

IMAGE: A Design Integration Framework Applied to the High Speed Civil Transport

NASA Technical Reports Server (NTRS)

Hale, Mark A.; Craig, James I.

1993-01-01

Effective design of the High Speed Civil Transport requires the systematic application of design resources throughout a product's life-cycle. Information obtained from the use of these resources is used for the decision-making processes of Concurrent Engineering. Integrated computing environments facilitate the acquisition, organization, and use of required information. State-of-the-art computing technologies provide the basis for the Intelligent Multi-disciplinary Aircraft Generation Environment (IMAGE) described in this paper. IMAGE builds upon existing agent technologies by adding a new component called a model. With the addition of a model, the agent can provide accountable resource utilization in the presence of increasing design fidelity. The development of a zeroth-order agent is used to illustrate agent fundamentals. Using a CATIA(TM)-based agent from previous work, a High Speed Civil Transport visualization system linking CATIA, FLOPS, and ASTROS will be shown. These examples illustrate the important role of the agent technologies used to implement IMAGE, and together they demonstrate that IMAGE can provide an integrated computing environment for the design of the High Speed Civil Transport.

The application of digital techniques to the analysis of metallurgical experiments

NASA Technical Reports Server (NTRS)

Rathz, T. J.

1977-01-01

The application of a specific digital computer system (known as the Image Data Processing System) to the analysis of three NASA-sponsored metallurgical experiments is discussed in some detail. The basic hardware and software components of the Image Data Processing System are presented. Many figures are presented in the discussion of each experimental analysis in an attempt to show the accuracy and speed that the Image Data Processing System affords in analyzing photographic images dealing with metallurgy, and in particular with material processing.

Transonic applications of the Wake Imaging System

NASA Astrophysics Data System (ADS)

Crowder, J. P.

1982-09-01

The extension of a rapid flow field survey method (wake imaging system) originally developed for low speed wind tunnel operation, to transonic wind tunnel applications is discussed. The advantage of the system, beside the simplicity and low cost of the data acquisition system, is that the probe position data are recorded as an optical image of the actual sensor and thus are unaffected by the inevitable deflections of the probe support. This permits traversing systems which are deliberately flexible and have unusual motions. Two transverse drive systems are described and several typical data images are given.

High-speed adaptive optics line scan confocal retinal imaging for human eye

PubMed Central

Wang, Xiaolin; Zhang, Yuhua

2017-01-01

Purpose Continuous and rapid eye movement causes significant intraframe distortion in adaptive optics high resolution retinal imaging. To minimize this artifact, we developed a high speed adaptive optics line scan confocal retinal imaging system. Methods A high speed line camera was employed to acquire retinal image and custom adaptive optics was developed to compensate the wave aberration of the human eye’s optics. The spatial resolution and signal to noise ratio were assessed in model eye and in living human eye. The improvement of imaging fidelity was estimated by reduction of intra-frame distortion of retinal images acquired in the living human eyes with frame rates at 30 frames/second (FPS), 100 FPS, and 200 FPS. Results The device produced retinal image with cellular level resolution at 200 FPS with a digitization of 512×512 pixels/frame in the living human eye. Cone photoreceptors in the central fovea and rod photoreceptors near the fovea were resolved in three human subjects in normal chorioretinal health. Compared with retinal images acquired at 30 FPS, the intra-frame distortion in images taken at 200 FPS was reduced by 50.9% to 79.7%. Conclusions We demonstrated the feasibility of acquiring high resolution retinal images in the living human eye at a speed that minimizes retinal motion artifact. This device may facilitate research involving subjects with nystagmus or unsteady fixation due to central vision loss. PMID:28257458

High-speed adaptive optics line scan confocal retinal imaging for human eye.

PubMed

Lu, Jing; Gu, Boyu; Wang, Xiaolin; Zhang, Yuhua

2017-01-01

Continuous and rapid eye movement causes significant intraframe distortion in adaptive optics high resolution retinal imaging. To minimize this artifact, we developed a high speed adaptive optics line scan confocal retinal imaging system. A high speed line camera was employed to acquire retinal image and custom adaptive optics was developed to compensate the wave aberration of the human eye's optics. The spatial resolution and signal to noise ratio were assessed in model eye and in living human eye. The improvement of imaging fidelity was estimated by reduction of intra-frame distortion of retinal images acquired in the living human eyes with frame rates at 30 frames/second (FPS), 100 FPS, and 200 FPS. The device produced retinal image with cellular level resolution at 200 FPS with a digitization of 512×512 pixels/frame in the living human eye. Cone photoreceptors in the central fovea and rod photoreceptors near the fovea were resolved in three human subjects in normal chorioretinal health. Compared with retinal images acquired at 30 FPS, the intra-frame distortion in images taken at 200 FPS was reduced by 50.9% to 79.7%. We demonstrated the feasibility of acquiring high resolution retinal images in the living human eye at a speed that minimizes retinal motion artifact. This device may facilitate research involving subjects with nystagmus or unsteady fixation due to central vision loss.

Microarthroscopy System With Image Processing Technology Developed for Minimally Invasive Surgery

NASA Technical Reports Server (NTRS)

Steele, Gynelle C.

2001-01-01

In a joint effort, NASA, Micro Medical Devices, and the Cleveland Clinic have developed a microarthroscopy system with digital image processing. This system consists of a disposable endoscope the size of a needle that is aimed at expanding the use of minimally invasive surgery on the knee, ankle, and other small joints. This device not only allows surgeons to make smaller incisions (by improving the clarity and brightness of images), but it gives them a better view of the injured area to make more accurate diagnoses. Because of its small size, the endoscope helps reduce physical trauma and speeds patient recovery. The faster recovery rate also makes the system cost effective for patients. The digital image processing software used with the device was originally developed by the NASA Glenn Research Center to conduct computer simulations of satellite positioning in space. It was later modified to reflect lessons learned in enhancing photographic images in support of the Center's microgravity program. Glenn's Photovoltaic Branch and Graphics and Visualization Lab (G-VIS) computer programmers and software developers enhanced and speed up graphic imaging for this application. Mary Vickerman at Glenn developed algorithms that enabled Micro Medical Devices to eliminate interference and improve the images.

In vivo imaging of the rodent eye with swept source/Fourier domain OCT

PubMed Central

Liu, Jonathan J.; Grulkowski, Ireneusz; Kraus, Martin F.; Potsaid, Benjamin; Lu, Chen D.; Baumann, Bernhard; Duker, Jay S.; Hornegger, Joachim; Fujimoto, James G.

2013-01-01

Swept source/Fourier domain OCT is demonstrated for in vivo imaging of the rodent eye. Using commercial swept laser technology, we developed a prototype OCT imaging system for small animal ocular imaging operating in the 1050 nm wavelength range at an axial scan rate of 100 kHz with ~6 µm axial resolution. The high imaging speed enables volumetric imaging with high axial scan densities, measuring high flow velocities in vessels, and repeated volumetric imaging over time. The 1050 nm wavelength light provides increased penetration into tissue compared to standard commercial OCT systems at 850 nm. The long imaging range enables multiple operating modes for imaging the retina, posterior eye, as well as anterior eye and full eye length. A registration algorithm using orthogonally scanned OCT volumetric data sets which can correct motion on a per A-scan basis is applied to compensate motion and merge motion corrected volumetric data for enhanced OCT image quality. Ultrahigh speed swept source OCT is a promising technique for imaging the rodent eye, proving comprehensive information on the cornea, anterior segment, lens, vitreous, posterior segment, retina and choroid. PMID:23412778

Clinical comparative study with a large-area amorphous silicon flat-panel detector: image quality and visibility of anatomic structures on chest radiography.

PubMed

Fink, Christian; Hallscheidt, Peter J; Noeldge, Gerd; Kampschulte, Annette; Radeleff, Boris; Hosch, Waldemar P; Kauffmann, Günter W; Hansmann, Jochen

2002-02-01

The objective of this study was to compare clinical chest radiographs of a large-area, flat-panel digital radiography system and a conventional film-screen radiography system. The comparison was based on an observer preference study of image quality and visibility of anatomic structures. Routine follow-up chest radiographs were obtained from 100 consecutive oncology patients using a large-area, amorphous silicon flat-panel detector digital radiography system (dose equivalent to a 400-speed film system). Hard-copy images were compared with previous examinations of the same individuals taken on a conventional film-screen system (200-speed). Patients were excluded if changes in the chest anatomy were detected or if the time interval between the examinations exceeded 1 year. Observer preference was evaluated for the image quality and the visibility of 15 anatomic structures using a five-point scale. Dose measurements with a chest phantom showed a dose reduction of approximately 50% with the digital radiography system compared with the film-screen radiography system. The image quality and the visibility of all but one anatomic structure of the images obtained with the digital flat-panel detector system were rated significantly superior (p < or = 0.0003) to those obtained with the conventional film-screen radiography system. The image quality and visibility of anatomic structures on the images obtained by the flat-panel detector system were perceived as equal or superior to the images from conventional film-screen chest radiography. This was true even though the radiation dose was reduced approximately 50% with the digital flat-panel detector system.

Ultrahigh phase-stable swept-source optical coherence tomography as a cardiac imaging platform (Conference Presentation)

NASA Astrophysics Data System (ADS)

Ling, Yuye; Hendon, Christine P.

2016-02-01

Functional extensions to optical coherence tomography (OCT) provide useful imaging contrasts that are complementary to conventional OCT. Our goal is to characterize tissue types within the myocardial due to remodeling and therapy. High-speed imaging is necessary to extract mechanical properties and dynamics of fiber orientation changes in a beating heart. Functional extensions of OCT such as polarization sensitive and optical coherence elastography (OCE) require high phase stability of the system, which is a drawback of current mechanically tuned swept source OCT systems. Here we present a high-speed functional imaging platform, which includes an ultrahigh-phase-stable swept source equipped with KTN deflector from NTT-AT. The swept source does not require mechanical movements during the wavelength sweeping; it is electrically tuned. The inter-sweep phase variance of the system was measured to be less than 300 ps at a path length difference of ~2 mm. The axial resolution of the system is 20 µm and the -10 dB fall-off depth is about 3.2 mm. The sample arm has an 8 mmx8 mm field of view with a lateral resolution of approximately 18 µm. The sample arm uses a two-axis MEMS mirror, which is programmable and capable of scanning arbitrary patterns at a sampling rate of 50 kHz. Preliminary imaging results showed differences in polarization properties and image penetration in ablated and normal myocardium. In the future, we will conduct dynamic stretching experiments with strips of human myocardial tissue to characterize mechanical properties using OCE. With high speed imaging of 200 kHz and an all-fiber design, we will work towards catheter-based functional imaging.

Superficial Ultrasound Shear Wave Speed Measurements in Soft and Hard Elasticity Phantoms: Repeatability and Reproducibility Using Two Different Ultrasound Systems

PubMed Central

Dillman, Jonathan R.; Chen, Shigao; Davenport, Matthew S.; Zhao, Heng; Urban, Matthew W.; Song, Pengfei; Watcharotone, Kuanwong; Carson, Paul L.

2014-01-01

Background There is a paucity of data available regarding the repeatability and reproducibility of superficial shear wave speed (SWS) measurements at imaging depths relevant to the pediatric population. Purpose To assess the repeatability and reproducibility of superficial shear wave speed (SWS) measurements acquired from elasticity phantoms at varying imaging depths using three different imaging methods, two different ultrasound systems, and multiple operators. Methods and Materials Soft and hard elasticity phantoms manufactured by Computerized Imaging Reference Systems, Inc. (Norfolk, VA) were utilized for our investigation. Institution #1 used an Acuson S3000 ultrasound system (Siemens Medical Solutions USA, Inc.) and three different shear wave imaging method/transducer combinations, while institution #2 used an Aixplorer ultrasound system (Supersonic Imagine) and two different transducers. Ten stiffness measurements were acquired from each phantom at three depths (1.0, 2.5, and 4.0 cm) by four operators at each institution. Student’s t-test was used to compare SWS measurements between imaging techniques, while SWS measurement agreement was assessed with two-way random effects single measure intra-class correlation coefficients and coefficients of variation. Mixed model regression analysis determined the effect of predictor variables on SWS measurements. Results For the soft phantom, the average of mean SWS measurements across the various imaging methods and depths was 0.84 ± 0.04 m/s (mean ± standard deviation) for the Acuson S3000 system and 0.90 ± 0.02 m/s for the Aixplorer system (p=0.003). For the hard phantom, the average of mean SWS measurements across the various imaging methods and depths was 2.14 ± 0.08 m/s for the Acuson S3000 system and 2.07 ± 0.03 m/s Aixplorer system (p>0.05). The coefficients of variation were low (0.5–6.8%), and inter-operator agreement was near-perfect (ICCs ≥0.99). Shear wave imaging method and imaging depth significantly affected measured SWS (p<0.0001). Conclusions Superficial SWS measurements in elasticity phantoms demonstrate minimal variability across imaging method/transducer combinations, imaging depths, and between operators. The exact clinical significance of this variability is uncertain and may vary by organ and specific disease state. PMID:25249389

Corneal topography with high-speed swept source OCT in clinical examination

PubMed Central

Karnowski, Karol; Kaluzny, Bartlomiej J.; Szkulmowski, Maciej; Gora, Michalina; Wojtkowski, Maciej

2011-01-01

We present the applicability of high-speed swept source (SS) optical coherence tomography (OCT) for quantitative evaluation of the corneal topography. A high-speed OCT device of 108,000 lines/s permits dense 3D imaging of the anterior segment within a time period of less than one fourth of second, minimizing the influence of motion artifacts on final images and topographic analysis. The swept laser performance was specially adapted to meet imaging depth requirements. For the first time to our knowledge the results of a quantitative corneal analysis based on SS OCT for clinical pathologies such as keratoconus, a cornea with superficial postinfectious scar, and a cornea 5 months after penetrating keratoplasty are presented. Additionally, a comparison with widely used commercial systems, a Placido-based topographer and a Scheimpflug imaging-based topographer, is demonstrated. PMID:21991558

Real-time correction of beamforming time delay errors in abdominal ultrasound imaging

NASA Astrophysics Data System (ADS)

Rigby, K. W.

2000-04-01

The speed of sound varies with tissue type, yet commercial ultrasound imagers assume a constant sound speed. Sound speed variation in abdominal fat and muscle layers is widely believed to be largely responsible for poor contrast and resolution in some patients. The simplest model of the abdominal wall assumes that it adds a spatially varying time delay to the ultrasound wavefront. The adequacy of this model is controversial. We describe an adaptive imaging system consisting of a GE LOGIQ 700 imager connected to a multi- processor computer. Arrival time errors for each beamforming channel, estimated by correlating each channel signal with the beamsummed signal, are used to correct the imager's beamforming time delays at the acoustic frame rate. A multi- row transducer provides two-dimensional sampling of arrival time errors. We observe significant improvement in abdominal images of healthy male volunteers: increased contrast of blood vessels, increased visibility of the renal capsule, and increased brightness of the liver.

A high-speed trapezoid image sensor design for continuous traffic monitoring at signalized intersection approaches.

DOT National Transportation Integrated Search

2014-10-01

The goal of this project is to monitor traffic flow continuously with an innovative camera system composed of a custom : designed image sensor integrated circuit (IC) containing trapezoid pixel array and camera system that is capable of : intelligent...

New concept high-speed and high-resolution color scanner

NASA Astrophysics Data System (ADS)

Nakashima, Keisuke; Shinoda, Shin'ichi; Konishi, Yoshiharu; Sugiyama, Kenji; Hori, Tetsuya

2003-05-01

We have developed a new concept high-speed and high-resolution color scanner (Blinkscan) using digital camera technology. With our most advanced sub-pixel image processing technology, approximately 12 million pixel image data can be captured. High resolution imaging capability allows various uses such as OCR, color document read, and document camera. The scan time is only about 3 seconds for a letter size sheet. Blinkscan scans documents placed "face up" on its scan stage and without any special illumination lights. Using Blinkscan, a high-resolution color document can be easily inputted into a PC at high speed, a paperless system can be built easily. It is small, and since the occupancy area is also small, setting it on an individual desk is possible. Blinkscan offers the usability of a digital camera and accuracy of a flatbed scanner with high-speed processing. Now, about several hundred of Blinkscan are mainly shipping for the receptionist operation in a bank and a security. We will show the high-speed and high-resolution architecture of Blinkscan. Comparing operation-time with conventional image capture device, the advantage of Blinkscan will make clear. And image evaluation for variety of environment, such as geometric distortions or non-uniformity of brightness, will be made.

High-speed schlieren imaging of rocket exhaust plumes

NASA Astrophysics Data System (ADS)

Coultas-McKenney, Caralyn; Winter, Kyle; Hargather, Michael

2016-11-01

Experiments are conducted to examine the exhaust of a variety of rocket engines. The rocket engines are mounted in a schlieren system to allow high-speed imaging of the engine exhaust during startup, steady state, and shutdown. A variety of rocket engines are explored including a research-scale liquid rocket engine, consumer/amateur solid rocket motors, and water bottle rockets. Comparisons of the exhaust characteristics, thrust and cost for this range of rockets is presented. The variety of nozzle designs, target functions, and propellant type provides unique variations in the schlieren imaging.

Versatile quantitative phase imaging system applied to high-speed, low noise and multimodal imaging (Conference Presentation)

NASA Astrophysics Data System (ADS)

Federici, Antoine; Aknoun, Sherazade; Savatier, Julien; Wattellier, Benoit F.

2017-02-01

Quadriwave lateral shearing interferometry (QWLSI) is a well-established quantitative phase imaging (QPI) technique based on the analysis of interference patterns of four diffraction orders by an optical grating set in front of an array detector [1]. As a QPI modality, this is a non-invasive imaging technique which allow to measure the optical path difference (OPD) of semi-transparent samples. We present a system enabling QWLSI with high-performance sCMOS cameras [2] and apply it to perform high-speed imaging, low noise as well as multimodal imaging. This modified QWLSI system contains a versatile optomechanical device which images the optical grating near the detector plane. Such a device is coupled with any kind of camera by varying its magnification. In this paper, we study the use of a sCMOS Zyla5.5 camera from Andor along with our modified QWLSI system. We will present high-speed live cell imaging, up to 200Hz frame rate, in order to follow intracellular fast motions while measuring the quantitative phase information. The structural and density information extracted from the OPD signal is complementary to the specific and localized fluorescence signal [2]. In addition, QPI detects cells even when the fluorophore is not expressed. This is very useful to follow a protein expression with time. The 10 µm spatial pixel resolution of our modified QWLSI associated to the high sensitivity of the Zyla5.5 enabling to perform high quality fluorescence imaging, we have carried out multimodal imaging revealing fine structures cells, like actin filaments, merged with the morphological information of the phase. References [1]. P. Bon, G. Maucort, B. Wattellier, and S. Monneret, "Quadriwave lateral shearing interferometry for quantitative phase microscopy of living cells," Opt. Express, vol. 17, pp. 13080-13094, 2009. [2] P. Bon, S. Lécart, E. Fort and S. Lévêque-Fort, "Fast label-free cytoskeletal network imaging in living mammalian cells," Biophysical journal, 106(8), pp. 1588-1595, 2014

Two-dimensional tracking of a motile micro-organism allowing high-resolution observation with various imaging techniques

NASA Astrophysics Data System (ADS)

Oku, H.; Ogawa, N.; Ishikawa, M.; Hashimoto, K.

2005-03-01

In this article, a micro-organism tracking system using a high-speed vision system is reported. This system two dimensionally tracks a freely swimming micro-organism within the field of an optical microscope by moving a chamber of target micro-organisms based on high-speed visual feedback. The system we developed could track a paramecium using various imaging techniques, including bright-field illumination, dark-field illumination, and differential interference contrast, at magnifications of 5 times and 20 times. A maximum tracking duration of 300s was demonstrated. Also, the system could track an object with a velocity of up to 35 000μm/s (175diameters/s), which is significantly faster than swimming micro-organisms.

Laser beam welding quality monitoring system based in high-speed (10 kHz) uncooled MWIR imaging sensors

NASA Astrophysics Data System (ADS)

Linares, Rodrigo; Vergara, German; Gutiérrez, Raúl; Fernández, Carlos; Villamayor, Víctor; Gómez, Luis; González-Camino, Maria; Baldasano, Arturo; Castro, G.; Arias, R.; Lapido, Y.; Rodríguez, J.; Romero, Pablo

2015-05-01

The combination of flexibility, productivity, precision and zero-defect manufacturing in future laser-based equipment are a major challenge that faces this enabling technology. New sensors for online monitoring and real-time control of laserbased processes are necessary for improving products quality and increasing manufacture yields. New approaches to fully automate processes towards zero-defect manufacturing demand smarter heads where lasers, optics, actuators, sensors and electronics will be integrated in a unique compact and affordable device. Many defects arising in laser-based manufacturing processes come from instabilities in the dynamics of the laser process. Temperature and heat dynamics are key parameters to be monitored. Low cost infrared imagers with high-speed of response will constitute the next generation of sensors to be implemented in future monitoring and control systems for laser-based processes, capable to provide simultaneous information about heat dynamics and spatial distribution. This work describes the result of using an innovative low-cost high-speed infrared imager based on the first quantum infrared imager monolithically integrated with Si-CMOS ROIC of the market. The sensor is able to provide low resolution images at frame rates up to 10 KHz in uncooled operation at the same cost as traditional infrared spot detectors. In order to demonstrate the capabilities of the new sensor technology, a low-cost camera was assembled on a standard production laser welding head, allowing to register melting pool images at frame rates of 10 kHz. In addition, a specific software was developed for defect detection and classification. Multiple laser welding processes were recorded with the aim to study the performance of the system and its application to the real-time monitoring of laser welding processes. During the experiments, different types of defects were produced and monitored. The classifier was fed with the experimental images obtained. Self-learning strategies were implemented with very promising results, demonstrating the feasibility of using low-cost high-speed infrared imagers in advancing towards a real-time / in-line zero-defect production systems.

High-speed optical 3D sensing and its applications

NASA Astrophysics Data System (ADS)

Watanabe, Yoshihiro

2016-12-01

This paper reviews high-speed optical 3D sensing technologies for obtaining the 3D shape of a target using a camera. The focusing speed is from 100 to 1000 fps, exceeding normal camera frame rates, which are typically 30 fps. In particular, contactless, active, and real-time systems are introduced. Also, three example applications of this type of sensing technology are introduced, including surface reconstruction from time-sequential depth images, high-speed 3D user interaction, and high-speed digital archiving.

Three-dimensional radar imaging techniques and systems for near-field applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sheen, David M.; Hall, Thomas E.; McMakin, Douglas L.

2016-05-12

The Pacific Northwest National Laboratory has developed three-dimensional holographic (synthetic aperture) radar imaging techniques and systems for a wide variety of near-field applications. These applications include radar cross-section (RCS) imaging, personnel screening, standoff concealed weapon detection, concealed threat detection, through-barrier imaging, ground penetrating radar (GPR), and non-destructive evaluation (NDE). Sequentially-switched linear arrays are used for many of these systems to enable high-speed data acquisition and 3-D imaging. In this paper, the techniques and systems will be described along with imaging results that demonstrate the utility of near-field 3-D radar imaging for these compelling applications.

Field-based high-speed imaging of explosive eruptions

NASA Astrophysics Data System (ADS)

Taddeucci, J.; Scarlato, P.; Freda, C.; Moroni, M.

2012-12-01

Explosive eruptions involve, by definition, physical processes that are highly dynamic over short time scales. Capturing and parameterizing such processes is a major task in eruption understanding and forecasting, and a task that necessarily requires observational systems capable of high sampling rates. Seismic and acoustic networks are a prime tool for high-frequency observation of eruption, recently joined by Doppler radar and electric sensors. In comparison with the above monitoring systems, imaging techniques provide more complete and direct information of surface processes, but usually at a lower sampling rate. However, recent developments in high-speed imaging systems now allow such information to be obtained with a spatial and temporal resolution suitable for the analysis of several key eruption processes. Our most recent set up for high-speed imaging of explosive eruptions (FAMoUS - FAst, MUltiparametric Set-up,) includes: 1) a monochrome high speed camera, capable of 500 frames per second (fps) at high-definition (1280x1024 pixel) resolution and up to 200000 fps at reduced resolution; 2) a thermal camera capable of 50-200 fps at 480-120x640 pixel resolution; and 3) two acoustic to infrasonic sensors. All instruments are time-synchronized via a data logging system, a hand- or software-operated trigger, and via GPS, allowing signals from other instruments or networks to be directly recorded by the same logging unit or to be readily synchronized for comparison. FAMoUS weights less than 20 kg, easily fits into four, hand-luggage-sized backpacks, and can be deployed in less than 20' (and removed in less than 2', if needed). So far, explosive eruptions have been recorded in high-speed at several active volcanoes, including Fuego and Santiaguito (Guatemala), Stromboli (Italy), Yasur (Vanuatu), and Eyjafiallajokull (Iceland). Image processing and analysis from these eruptions helped illuminate several eruptive processes, including: 1) Pyroclasts ejection. High-speed videos reveal multiple, discrete ejection pulses within a single Strombolian explosion, with ejection velocities twice as high as previously recorded. Video-derived information on ejection velocity and ejecta mass can be combined with analytical and experimental models to constrain the physical parameters of the gas driving individual pulses. 2) Jet development. The ejection trajectory of pyroclasts can also be used to outline the spatial and temporal development of the eruptive jet and the dynamics of gas-pyroclast coupling within the jet, while high-speed thermal images add information on the temperature evolution in the jet itself as a function of the pyroclast size and content. 2) Pyroclasts settling. High-speed videos can be used to investigate the aerodynamic settling behavior of pyroclasts from bomb to ash in size and including ash aggregates, providing key parameters such as drag coefficient as a function of Re, and particle density. 3) The generation and propagation of acoustic and shock waves. Phase condensation in volcanic and atmospheric aerosol is triggered by the transit of pressure waves and can be recorded in high-speed videos, allowing the speed and wavelength of the waves to be measured and compared with the corresponding infrasonic signals and theoretical predictions.

A Low-Power High-Speed Smart Sensor Design for Space Exploration Missions

NASA Technical Reports Server (NTRS)

Fang, Wai-Chi

1997-01-01

A low-power high-speed smart sensor system based on a large format active pixel sensor (APS) integrated with a programmable neural processor for space exploration missions is presented. The concept of building an advanced smart sensing system is demonstrated by a system-level microchip design that is composed with an APS sensor, a programmable neural processor, and an embedded microprocessor in a SOI CMOS technology. This ultra-fast smart sensor system-on-a-chip design mimics what is inherent in biological vision systems. Moreover, it is programmable and capable of performing ultra-fast machine vision processing in all levels such as image acquisition, image fusion, image analysis, scene interpretation, and control functions. The system provides about one tera-operation-per-second computing power which is a two order-of-magnitude increase over that of state-of-the-art microcomputers. Its high performance is due to massively parallel computing structures, high data throughput rates, fast learning capabilities, and advanced VLSI system-on-a-chip implementation.

Effect of developer temperature changes on the sensitometric properties of direct exposure and screen-film imaging systems.

PubMed

Kircos, L T; Staninec, M; Chou, L S

1989-02-01

A heat exchanger was developed and incorporated into the recirculation system of a dental processor to maintain strict temperature control. Without the heat exchanger, developer temperature rose steadily over 8 h to a maximum of 35.7 degrees C: with the heat exchanger it was maintained, regardless of ambient conditions, at the desired temperature with virtually no fluctuation. Sensitometric properties of base and fog, speed, and average gradient were measured for D and E speed films and Lanex Regular/T-Mat G and Lanex Fast/T-Mat Hscreen-film systems at developer temperatures of 21.1, 23.8, 26.7, 29.4 and 32.2 degrees C. Small changes in these properties were found for D and E speed films: on the other hand, Lanex Regular/T-Mat G showed a 65% increase in base and fog and Lanex Fast/T-Mat H a 43% increase in average gradient over the temperature range studied. Although these changes may not be clinically significant for intra-oral and dental radiography, the variations in image quality may compromise controlled imaging experiments and clinically compromise radiographic quality when using screen-film systems.

TH-A-207B-01: Basics and Current Implementations of Ultrasound Imaging of Shear Wave Speed and Elasticity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, S.

Imaging of tissue elastic properties is a relatively new and powerful approach to one of the oldest and most important diagnostic tools. Imaging of shear wave speed with ultrasound is has been added to most high-end ultrasound systems. Understanding this exciting imaging mode aiding its most effective use in medicine can be a rewarding effort for medical physicists and other medical imaging and treatment professionals. Assuring consistent, quantitative measurements across the many ultrasound systems in a typical imaging department will constitute a major step toward realizing the great potential of this technique and other quantitative imaging. This session will targetmore » these two goals with two presentations. A. Basics and Current Implementations of Ultrasound Imaging of Shear Wave Speed and Elasticity - Shigao Chen, Ph.D. Learning objectives-To understand: Introduction: Importance of tissue elasticity measurement Strain vs. shear wave elastography (SWE), beneficial features of SWE The link between shear wave speed and material properties, influence of viscosity Generation of shear waves External vibration (Fibroscan) ultrasound radiation force Point push Supersonic push (Aixplorer) Comb push (GE Logiq E9) Detection of shear waves Motion detection from pulse-echo ultrasound Importance of frame rate for shear wave imaging Plane wave imaging detection How to achieve high effective frame rate using line-by-line scanners Shear wave speed calculation Time to peak Random sample consensus (RANSAC) Cross correlation Sources of bias and variation in SWE Tissue viscosity Transducer compression or internal pressure of organ Reflection of shear waves at boundaries B. Elasticity Imaging System Biomarker Qualification and User Testing of Systems – Brian Garra, M.D. Learning objectives-To understand: Goals Review the need for quantitative medical imaging Provide examples of quantitative imaging biomarkers Acquaint the participant with the purpose of the RSNA Quantitative Imaging Biomarker Alliance and the need for such an organization Review the QIBA process for creating a quantitative biomarker Summarize steps needed to verify adherence of site, operators, and imaging systems to a QIBA profile Underlying Premise and Assumptions Objective, quantifiable results are needed to enhance the value of diagnostic imaging in clinical practice Reasons for quantification Evidence based medicine requires objective, not subjective observer data Computerized decision support tools (eg CAD) generally require quantitative input. Quantitative, reproducible measures are more easily used to develop personalized molecular medical diagnostic and treatment systems What is quantitative imaging? Definition from Imaging Metrology Workshop The Quantitative Imaging Biomarker Alliance Formation 2008 Mission Structure Example Imaging Biomarkers Being Explored Biomarker Selection Groundwork Draft Protocol for imaging and data evaluation QIBA Profile Drafting Equipment and Site Validation Technical Clinical Site and Equipment QA and Compliance Checking Ultrasound Elasticity Estimation Biomarker US Elasticity Estimation Background Current Status and Problems Biomarker Selection-process and outcome US SWS for Liver Fibrosis Biomarker Work Groundwork Literature search and analysis results Phase I phantom testing-Elastic phantoms Phase II phantom testing-Viscoelastic phantoms Digital Simulated Data Protocol and Profile Drafting Protocol: based on UPICT and existing literature and standards bodies protocols Profile-Current claims, Manufacturer specific appendices What comes after the profile Profile Validation Technical validation Clinical validation QA and Compliance Possible approaches Site Operator testing Site protocol re-evaluation Imaging system Manufacturer testing and attestation User acceptance testing and periodic QA Phantom Tests Digital Phantom Based Testing Standard QA Testing Remediation Schemes Profile Evolution Towards additional applications Towards higher accuracy and precision Supported in part by NIH contract HHSN268201300071C from NIBIB. Collaboration with GE Global Research, no personal support.; S. Chen, Some technologies described in this presentation have been licensed. Mayo Clinic and Dr. Chen have financial interests these technologies.« less

Fast Fourier transform-based Retinex and alpha-rooting color image enhancement

NASA Astrophysics Data System (ADS)

Grigoryan, Artyom M.; Agaian, Sos S.; Gonzales, Analysa M.

2015-05-01

Efficiency in terms of both accuracy and speed is highly important in any system, especially when it comes to image processing. The purpose of this paper is to improve an existing implementation of multi-scale retinex (MSR) by utilizing the fast Fourier transforms (FFT) within the illumination estimation step of the algorithm to improve the speed at which Gaussian blurring filters were applied to the original input image. In addition, alpha-rooting can be used as a separate technique to achieve a sharper image in order to fuse its results with those of the retinex algorithm for the sake of achieving the best image possible as shown by the values of the considered color image enhancement measure (EMEC).

In situ health monitoring for bogie systems of CRH380 train on Beijing-Shanghai high-speed railway

NASA Astrophysics Data System (ADS)

Hong, Ming; Wang, Qiang; Su, Zhongqing; Cheng, Li

2014-04-01

Based on the authors' research efforts over the years, an in situ structural health monitoring (SHM) technique taking advantage of guided elastic waves has been developed and deployed via an online diagnosis system. The technique and the system were recently implemented on China's latest high-speed train (CRH380CL) operated on Beijing-Shanghai High-Speed Railway. The system incorporated modularized components including active sensor network, active wave generation, multi-channel data acquisition, signal processing, data fusion, and results presentation. The sensor network, inspired by a new concept—"decentralized standard sensing", was integrated into the bogie frames during the final assembly of CRH380CL, to generate and acquire bogie-guided ultrasonic waves, from which a wide array of signal features were extracted. Fusion of signal features through a diagnostic imaging algorithm led to a graphic illustration of the overall health state of the bogie in a real-time and intuitive manner. The in situ experimentation covered a variety of high-speed train operation events including startup, acceleration/deceleration, full-speed operation (300 km/h), emergency braking, track change, as well as full stop. Mock-up damage affixed to the bogie was identified quantitatively and visualized in images. This in situ testing has demonstrated the feasibility, effectiveness, sensitivity, and reliability of the developed SHM technique and the system towards real-world applications.

High-Speed Observer: Automated Streak Detection in SSME Plumes

NASA Technical Reports Server (NTRS)

Rieckoff, T. J.; Covan, M.; OFarrell, J. M.

2001-01-01

A high frame rate digital video camera installed on test stands at Stennis Space Center has been used to capture images of Space Shuttle main engine plumes during test. These plume images are processed in real time to detect and differentiate anomalous plume events occurring during a time interval on the order of 5 msec. Such speed yields near instantaneous availability of information concerning the state of the hardware. This information can be monitored by the test conductor or by other computer systems, such as the integrated health monitoring system processors, for possible test shutdown before occurrence of a catastrophic engine failure.

Particle Size Measurements From the First Fundamentals of Ice Crystal Icing Physics Test in the NASA Propulsion Systems Laboratory

NASA Technical Reports Server (NTRS)

King, Michael C.; Bachalo, William; Kurek, Andrzej

2017-01-01

This paper presents particle measurements by the Artium Technologies, Inc. Phase Doppler Interferometer and High Speed Imaging instruments from the first Fundamental Ice Crystal Icing Physics test conducted in the NASA Propulsion Systems Laboratory. The work focuses on humidity sweeps at a larger and a smaller median volumetric diameter. The particle size distribution, number density, and water content measured by the Phase Doppler Interferometer and High Speed Imaging instruments from the sweeps are presented and compared. The current capability for these two instruments to measure and discriminate ICI conditions is examined.

Particle Size Measurements from the first Fundamentals of Ice Crystal Icing Physics Test in the NASA Propulsion Systems Laboratory

NASA Technical Reports Server (NTRS)

King, Michael C.; Bachalo, William; Kurek, Andrzej

2017-01-01

This presentation shows particle measurements by the Artium Technologies, Inc. Phase Doppler Interferometer and High Speed Imaging instruments from the first Fundamental Ice Crystal Icing Physics test conducted in the NASA Propulsion Systems Laboratory. The work focuses on humidity sweeps at a larger and a smaller median volumetric diameter. The particle size distribution, number density, and water content measured by the Phase Doppler Interferometer and High Speed Imaging instruments from the sweeps are presented and compared. The current capability for these two instruments to measure and discriminate ICI conditions is examined.

Application of polarization in high speed, high contrast inspection

NASA Astrophysics Data System (ADS)

Novak, Matthew J.

2017-08-01

Industrial optical inspection often requires high speed and high throughput of materials. Engineers use a variety of techniques to handle these inspection needs. Some examples include line scan cameras, high speed multi-spectral and laser-based systems. High-volume manufacturing presents different challenges for inspection engineers. For example, manufacturers produce some components in quantities of millions per month, per week or even per day. Quality control of so many parts requires creativity to achieve the measurement needs. At times, traditional vision systems lack the contrast to provide the data required. In this paper, we show how dynamic polarization imaging captures high contrast images. These images are useful for engineers to perform inspection tasks in some cases where optical contrast is low. We will cover basic theory of polarization. We show how to exploit polarization as a contrast enhancement technique. We also show results of modeling for a polarization inspection application. Specifically, we explore polarization techniques for inspection of adhesives on glass.

Reducing misfocus-related motion artefacts in laser speckle contrast imaging.

PubMed

Ringuette, Dene; Sigal, Iliya; Gad, Raanan; Levi, Ofer

2015-01-01

Laser Speckle Contrast Imaging (LSCI) is a flexible, easy-to-implement technique for measuring blood flow speeds in-vivo. In order to obtain reliable quantitative data from LSCI the object must remain in the focal plane of the imaging system for the duration of the measurement session. However, since LSCI suffers from inherent frame-to-frame noise, it often requires a moving average filter to produce quantitative results. This frame-to-frame noise also makes the implementation of rapid autofocus system challenging. In this work, we demonstrate an autofocus method and system based on a novel measure of misfocus which serves as an accurate and noise-robust feedback mechanism. This measure of misfocus is shown to enable the localization of best focus with sub-depth-of-field sensitivity, yielding more accurate estimates of blood flow speeds and blood vessel diameters.

Label-Free Biomedical Imaging Using High-Speed Lock-In Pixel Sensor for Stimulated Raman Scattering

PubMed Central

Mars, Kamel; Kawahito, Shoji; Yasutomi, Keita; Kagawa, Keiichiro; Yamada, Takahiro

2017-01-01

Raman imaging eliminates the need for staining procedures, providing label-free imaging to study biological samples. Recent developments in stimulated Raman scattering (SRS) have achieved fast acquisition speed and hyperspectral imaging. However, there has been a problem of lack of detectors suitable for MHz modulation rate parallel detection, detecting multiple small SRS signals while eliminating extremely strong offset due to direct laser light. In this paper, we present a complementary metal-oxide semiconductor (CMOS) image sensor using high-speed lock-in pixels for stimulated Raman scattering that is capable of obtaining the difference of Stokes-on and Stokes-off signal at modulation frequency of 20 MHz in the pixel before reading out. The generated small SRS signal is extracted and amplified in a pixel using a high-speed and large area lateral electric field charge modulator (LEFM) employing two-step ion implantation and an in-pixel pair of low-pass filter, a sample and hold circuit and a switched capacitor integrator using a fully differential amplifier. A prototype chip is fabricated using 0.11 μm CMOS image sensor technology process. SRS spectra and images of stearic acid and 3T3-L1 samples are successfully obtained. The outcomes suggest that hyperspectral and multi-focus SRS imaging at video rate is viable after slight modifications to the pixel architecture and the acquisition system. PMID:29120358

Label-Free Biomedical Imaging Using High-Speed Lock-In Pixel Sensor for Stimulated Raman Scattering.

PubMed

Mars, Kamel; Lioe, De Xing; Kawahito, Shoji; Yasutomi, Keita; Kagawa, Keiichiro; Yamada, Takahiro; Hashimoto, Mamoru

2017-11-09

Raman imaging eliminates the need for staining procedures, providing label-free imaging to study biological samples. Recent developments in stimulated Raman scattering (SRS) have achieved fast acquisition speed and hyperspectral imaging. However, there has been a problem of lack of detectors suitable for MHz modulation rate parallel detection, detecting multiple small SRS signals while eliminating extremely strong offset due to direct laser light. In this paper, we present a complementary metal-oxide semiconductor (CMOS) image sensor using high-speed lock-in pixels for stimulated Raman scattering that is capable of obtaining the difference of Stokes-on and Stokes-off signal at modulation frequency of 20 MHz in the pixel before reading out. The generated small SRS signal is extracted and amplified in a pixel using a high-speed and large area lateral electric field charge modulator (LEFM) employing two-step ion implantation and an in-pixel pair of low-pass filter, a sample and hold circuit and a switched capacitor integrator using a fully differential amplifier. A prototype chip is fabricated using 0.11 μm CMOS image sensor technology process. SRS spectra and images of stearic acid and 3T3-L1 samples are successfully obtained. The outcomes suggest that hyperspectral and multi-focus SRS imaging at video rate is viable after slight modifications to the pixel architecture and the acquisition system.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Diaz, Ivan; Verdun, Francis R.; Bochud, François O., E-mail: francois.bochud@chuv.ch

Purpose: Signal detection on 3D medical images depends on many factors, such as foveal and peripheral vision, the type of signal, and background complexity, and the speed at which the frames are displayed. In this paper, the authors focus on the speed with which radiologists and naïve observers search through medical images. Prior to the study, the authors asked the radiologists to estimate the speed at which they scrolled through CT sets. They gave a subjective estimate of 5 frames per second (fps). The aim of this paper is to measure and analyze the speed with which humans scroll throughmore » image stacks, showing a method to visually display the behavior of observers as the search is made as well as measuring the accuracy of the decisions. This information will be useful in the development of model observers, mathematical algorithms that can be used to evaluate diagnostic imaging systems. Methods: The authors performed a series of 3D 4-alternative forced-choice lung nodule detection tasks on volumetric stacks of chest CT images iteratively reconstructed in lung algorithm. The strategy used by three radiologists and three naïve observers was assessed using an eye-tracker in order to establish where their gaze was fixed during the experiment and to verify that when a decision was made, a correct answer was not due only to chance. In a first set of experiments, the observers were restricted to read the images at three fixed speeds of image scrolling and were allowed to see each alternative once. In the second set of experiments, the subjects were allowed to scroll through the image stacks at will with no time or gaze limits. In both static-speed and free-scrolling conditions, the four image stacks were displayed simultaneously. All trials were shown at two different image contrasts. Results: The authors were able to determine a histogram of scrolling speeds in frames per second. The scrolling speed of the naïve observers and the radiologists at the moment the signal was detected was measured at 25–30 fps. For the task chosen, the performance of the observers was not affected by the contrast or experience of the observer. However, the naïve observers exhibited a different pattern of scrolling than the radiologists, which included a tendency toward higher number of direction changes and number of slices viewed. Conclusions: The authors have determined a distribution of speeds for volumetric detection tasks. The speed at detection was higher than that subjectively estimated by the radiologists before the experiment. The speed information that was measured will be useful in the development of 3D model observers, especially anthropomorphic model observers which try to mimic human behavior.« less

Vibration extraction based on fast NCC algorithm and high-speed camera.

PubMed

Lei, Xiujun; Jin, Yi; Guo, Jie; Zhu, Chang'an

2015-09-20

In this study, a high-speed camera system is developed to complete the vibration measurement in real time and to overcome the mass introduced by conventional contact measurements. The proposed system consists of a notebook computer and a high-speed camera which can capture the images as many as 1000 frames per second. In order to process the captured images in the computer, the normalized cross-correlation (NCC) template tracking algorithm with subpixel accuracy is introduced. Additionally, a modified local search algorithm based on the NCC is proposed to reduce the computation time and to increase efficiency significantly. The modified algorithm can rapidly accomplish one displacement extraction 10 times faster than the traditional template matching without installing any target panel onto the structures. Two experiments were carried out under laboratory and outdoor conditions to validate the accuracy and efficiency of the system performance in practice. The results demonstrated the high accuracy and efficiency of the camera system in extracting vibrating signals.

Computer-aided diagnosis workstation and database system for chest diagnosis based on multi-helical CT images

NASA Astrophysics Data System (ADS)

Satoh, Hitoshi; Niki, Noboru; Mori, Kiyoshi; Eguchi, Kenji; Kaneko, Masahiro; Kakinuma, Ryutarou; Moriyama, Noriyuki; Ohmatsu, Hironobu; Masuda, Hideo; Machida, Suguru; Sasagawa, Michizou

2006-03-01

Multi-helical CT scanner advanced remarkably at the speed at which the chest CT images were acquired for mass screening. Mass screening based on multi-helical CT images requires a considerable number of images to be read. It is this time-consuming step that makes the use of helical CT for mass screening impractical at present. To overcome this problem, we have provided diagnostic assistance methods to medical screening specialists by developing a lung cancer screening algorithm that automatically detects suspected lung cancers in helical CT images and a coronary artery calcification screening algorithm that automatically detects suspected coronary artery calcification. We also have developed electronic medical recording system and prototype internet system for the community health in two or more regions by using the Virtual Private Network router and Biometric fingerprint authentication system and Biometric face authentication system for safety of medical information. Based on these diagnostic assistance methods, we have now developed a new computer-aided workstation and database that can display suspected lesions three-dimensionally in a short time. This paper describes basic studies that have been conducted to evaluate this new system. The results of this study indicate that our computer-aided diagnosis workstation and network system can increase diagnostic speed, diagnostic accuracy and safety of medical information.

High-speed Imaging of Global Surface Temperature Distributions on Hypersonic Ballistic-Range Projectiles

NASA Technical Reports Server (NTRS)

Wilder, Michael C.; Reda, Daniel C.

2004-01-01

The NASA-Ames ballistic range provides a unique capability for aerothermodynamic testing of configurations in hypersonic, real-gas, free-flight environments. The facility can closely simulate conditions at any point along practically any trajectory of interest experienced by a spacecraft entering an atmosphere. Sub-scale models of blunt atmospheric entry vehicles are accelerated by a two-stage light-gas gun to speeds as high as 20 times the speed of sound to fly ballistic trajectories through an 24 m long vacuum-rated test section. The test-section pressure (effective altitude), the launch velocity of the model (flight Mach number), and the test-section working gas (planetary atmosphere) are independently variable. The model travels at hypersonic speeds through a quiescent test gas, creating a strong bow-shock wave and real-gas effects that closely match conditions achieved during actual atmospheric entry. The challenge with ballistic range experiments is to obtain quantitative surface measurements from a model traveling at hypersonic speeds. The models are relatively small (less than 3.8 cm in diameter), which limits the spatial resolution possible with surface mounted sensors. Furthermore, since the model is in flight, surface-mounted sensors require some form of on-board telemetry, which must survive the massive acceleration loads experienced during launch (up to 500,000 gravities). Finally, the model and any on-board instrumentation will be destroyed at the terminal wall of the range. For these reasons, optical measurement techniques are the most practical means of acquiring data. High-speed thermal imaging has been employed in the Ames ballistic range to measure global surface temperature distributions and to visualize the onset of transition to turbulent-flow on the forward regions of hypersonic blunt bodies. Both visible wavelength and infrared high-speed cameras are in use. The visible wavelength cameras are intensified CCD imagers capable of integration times as short as 2 ns. The infrared camera uses an Indium Antimonide (InSb) sensor in the 3 to 5 micron band and is capable of integration times as short as 500 ns. The projectiles are imaged nearly head-on using expendable mirrors offset slightly from the flight path. The proposed paper will discuss the application of high-speed digital imaging systems in the NASA-Ames hypersonic ballistic range, and the challenges encountered when applying these systems. Example images of the thermal radiation from the blunt nose of projectiles flying at nearly 14 times the speed of sound will be given.

(abstract) A High Throughput 3-D Inner Product Processor

NASA Technical Reports Server (NTRS)

Daud, Tuan

1996-01-01

A particularily challenging image processing application is the real time scene acquisition and object discrimination. It requires spatio-temporal recognition of point and resolved objects at high speeds with parallel processing algorithms. Neural network paradigms provide fine grain parallism and, when implemented in hardware, offer orders of magnitude speed up. However, neural networks implemented on a VLSI chip are planer architectures capable of efficient processing of linear vector signals rather than 2-D images. Therefore, for processing of images, a 3-D stack of neural-net ICs receiving planar inputs and consuming minimal power are required. Details of the circuits with chip architectures will be described with need to develop ultralow-power electronics. Further, use of the architecture in a system for high-speed processing will be illustrated.

Document Image Processing: Going beyond the Black-and-White Barrier. Progress, Issues and Options with Greyscale and Colour Image Processing.

ERIC Educational Resources Information Center

Hendley, Tom

1995-01-01

Discussion of digital document image processing focuses on issues and options associated with greyscale and color image processing. Topics include speed; size of original document; scanning resolution; markets for different categories of scanners, including photographic libraries, publishing, and office applications; hybrid systems; data…

HIGH-SPEED IMAGING AND WAVEFRONT SENSING WITH AN INFRARED AVALANCHE PHOTODIODE ARRAY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baranec, Christoph; Atkinson, Dani; Hall, Donald

2015-08-10

Infrared avalanche photodiode (APD) arrays represent a panacea for many branches of astronomy by enabling extremely low-noise, high-speed, and even photon-counting measurements at near-infrared wavelengths. We recently demonstrated the use of an early engineering-grade infrared APD array that achieves a correlated double sampling read noise of 0.73 e{sup −} in the lab, and a total noise of 2.52 e{sup −} on sky, and supports simultaneous high-speed imaging and tip-tilt wavefront sensing with the Robo-AO visible-light laser adaptive optics (AO) system at the Palomar Observatory 1.5 m telescope. Here we report on the improved image quality simultaneously achieved at visible andmore » infrared wavelengths by using the array as part of an image stabilization control loop with AO-sharpened guide stars. We also discuss a newly enabled survey of nearby late M-dwarf multiplicity, as well as future uses of this technology in other AO and high-contrast imaging applications.« less

Integral Images: Efficient Algorithms for Their Computation and Storage in Resource-Constrained Embedded Vision Systems

PubMed Central

Ehsan, Shoaib; Clark, Adrian F.; ur Rehman, Naveed; McDonald-Maier, Klaus D.

2015-01-01

The integral image, an intermediate image representation, has found extensive use in multi-scale local feature detection algorithms, such as Speeded-Up Robust Features (SURF), allowing fast computation of rectangular features at constant speed, independent of filter size. For resource-constrained real-time embedded vision systems, computation and storage of integral image presents several design challenges due to strict timing and hardware limitations. Although calculation of the integral image only consists of simple addition operations, the total number of operations is large owing to the generally large size of image data. Recursive equations allow substantial decrease in the number of operations but require calculation in a serial fashion. This paper presents two new hardware algorithms that are based on the decomposition of these recursive equations, allowing calculation of up to four integral image values in a row-parallel way without significantly increasing the number of operations. An efficient design strategy is also proposed for a parallel integral image computation unit to reduce the size of the required internal memory (nearly 35% for common HD video). Addressing the storage problem of integral image in embedded vision systems, the paper presents two algorithms which allow substantial decrease (at least 44.44%) in the memory requirements. Finally, the paper provides a case study that highlights the utility of the proposed architectures in embedded vision systems. PMID:26184211

Integral Images: Efficient Algorithms for Their Computation and Storage in Resource-Constrained Embedded Vision Systems.

PubMed

Ehsan, Shoaib; Clark, Adrian F; Naveed ur Rehman; McDonald-Maier, Klaus D

2015-07-10

The integral image, an intermediate image representation, has found extensive use in multi-scale local feature detection algorithms, such as Speeded-Up Robust Features (SURF), allowing fast computation of rectangular features at constant speed, independent of filter size. For resource-constrained real-time embedded vision systems, computation and storage of integral image presents several design challenges due to strict timing and hardware limitations. Although calculation of the integral image only consists of simple addition operations, the total number of operations is large owing to the generally large size of image data. Recursive equations allow substantial decrease in the number of operations but require calculation in a serial fashion. This paper presents two new hardware algorithms that are based on the decomposition of these recursive equations, allowing calculation of up to four integral image values in a row-parallel way without significantly increasing the number of operations. An efficient design strategy is also proposed for a parallel integral image computation unit to reduce the size of the required internal memory (nearly 35% for common HD video). Addressing the storage problem of integral image in embedded vision systems, the paper presents two algorithms which allow substantial decrease (at least 44.44%) in the memory requirements. Finally, the paper provides a case study that highlights the utility of the proposed architectures in embedded vision systems.

Real-Time Imaging System for the OpenPET

NASA Astrophysics Data System (ADS)

Tashima, Hideaki; Yoshida, Eiji; Kinouchi, Shoko; Nishikido, Fumihiko; Inadama, Naoko; Murayama, Hideo; Suga, Mikio; Haneishi, Hideaki; Yamaya, Taiga

2012-02-01

The OpenPET and its real-time imaging capability have great potential for real-time tumor tracking in medical procedures such as biopsy and radiation therapy. For the real-time imaging system, we intend to use the one-pass list-mode dynamic row-action maximum likelihood algorithm (DRAMA) and implement it using general-purpose computing on graphics processing units (GPGPU) techniques. However, it is difficult to make consistent reconstructions in real-time because the amount of list-mode data acquired in PET scans may be large depending on the level of radioactivity, and the reconstruction speed depends on the amount of the list-mode data. In this study, we developed a system to control the data used in the reconstruction step while retaining quantitative performance. In the proposed system, the data transfer control system limits the event counts to be used in the reconstruction step according to the reconstruction speed, and the reconstructed images are properly intensified by using the ratio of the used counts to the total counts. We implemented the system on a small OpenPET prototype system and evaluated the performance in terms of the real-time tracking ability by displaying reconstructed images in which the intensity was compensated. The intensity of the displayed images correlated properly with the original count rate and a frame rate of 2 frames per second was achieved with average delay time of 2.1 s.

Ultrahigh speed endoscopic optical coherence tomography for gastroenterology.

PubMed

Tsai, Tsung-Han; Lee, Hsiang-Chieh; Ahsen, Osman O; Liang, Kaicheng; Giacomelli, Michael G; Potsaid, Benjamin M; Tao, Yuankai K; Jayaraman, Vijaysekhar; Figueiredo, Marisa; Huang, Qin; Cable, Alex E; Fujimoto, James; Mashimo, Hiroshi

2014-12-01

We describe an ultrahigh speed endoscopic swept source optical coherence tomography (OCT) system for clinical gastroenterology using a vertical-cavity surface-emitting laser (VCSEL) and micromotor imaging catheter. The system had a 600 kHz axial scan rate and 8 µm axial resolution in tissue. Imaging was performed with a 3.2 mm diameter imaging catheter at 400 frames per second with a 12 µm spot size. Three-dimensional OCT (3D-OCT) imaging was performed in patients with a cross section of pathologies undergoing upper and lower endoscopy. The use of distally actuated imaging catheters enabled OCT imaging with more flexibility, such as volumetric imaging in the small intestine and the assessment of hiatal hernia using retroflex imaging. The high rotational scanning stability of the micromotor enabled 3D volumetric imaging with micron scale volumetric accuracy for both en face OCT and cross-sectional imaging, as well as OCT angiography (OCTA) for 3D visualization of subsurface microvasculature. The ability to perform both structural and functional 3D OCT imaging in the GI tract with microscopic accuracy should enable a wide range of studies and enhance the sensitivity and specificity of OCT for detecting pathology.

Ultrahigh speed endoscopic optical coherence tomography for gastroenterology

PubMed Central

Tsai, Tsung-Han; Lee, Hsiang-Chieh; Ahsen, Osman O.; Liang, Kaicheng; Giacomelli, Michael G.; Potsaid, Benjamin M.; Tao, Yuankai K.; Jayaraman, Vijaysekhar; Figueiredo, Marisa; Huang, Qin; Cable, Alex E.; Fujimoto, James; Mashimo, Hiroshi

2014-01-01

We describe an ultrahigh speed endoscopic swept source optical coherence tomography (OCT) system for clinical gastroenterology using a vertical-cavity surface-emitting laser (VCSEL) and micromotor imaging catheter. The system had a 600 kHz axial scan rate and 8 µm axial resolution in tissue. Imaging was performed with a 3.2 mm diameter imaging catheter at 400 frames per second with a 12 µm spot size. Three-dimensional OCT (3D-OCT) imaging was performed in patients with a cross section of pathologies undergoing upper and lower endoscopy. The use of distally actuated imaging catheters enabled OCT imaging with more flexibility, such as volumetric imaging in the small intestine and the assessment of hiatal hernia using retroflex imaging. The high rotational scanning stability of the micromotor enabled 3D volumetric imaging with micron scale volumetric accuracy for both en face OCT and cross-sectional imaging, as well as OCT angiography (OCTA) for 3D visualization of subsurface microvasculature. The ability to perform both structural and functional 3D OCT imaging in the GI tract with microscopic accuracy should enable a wide range of studies and enhance the sensitivity and specificity of OCT for detecting pathology. PMID:25574446

A new continuous light source for high-speed imaging

NASA Astrophysics Data System (ADS)

Paton, R. T.; Hall, R. E.; Skews, B. W.

2017-02-01

Xenon arc lamps have been identified as a suitable continuous light source for high-speed imaging, specifically high-speed Schlieren and shadowgraphy. One issue when setting us such systems is the time that it takes to reduce a finite source to the approximation of a point source for z-type schlieren. A preliminary design of a compact compound lens for use with a commercial Xenon arc lamp was tested for suitability. While it was found that there is some dimming of the illumination at the spot periphery, the overall spectral and luminance distribution of the compact source is quite acceptable, especially considering the time benefit that it represents.

Error mapping of high-speed AFM systems

NASA Astrophysics Data System (ADS)

Klapetek, Petr; Picco, Loren; Payton, Oliver; Yacoot, Andrew; Miles, Mervyn

2013-02-01

In recent years, there have been several advances in the development of high-speed atomic force microscopes (HSAFMs) to obtain images with nanometre vertical and lateral resolution at frame rates in excess of 1 fps. To date, these instruments are lacking in metrology for their lateral scan axes; however, by imaging a series of two-dimensional lateral calibration standards, it has been possible to obtain information about the errors associated with these HSAFM scan axes. Results from initial measurements are presented in this paper and show that the scan speed needs to be taken into account when performing a calibration as it can lead to positioning errors of up to 3%.

Measurement of instantaneous rotational speed using double-sine-varying-density fringe pattern

NASA Astrophysics Data System (ADS)

Zhong, Jianfeng; Zhong, Shuncong; Zhang, Qiukun; Peng, Zhike

2018-03-01

Fast and accurate rotational speed measurement is required both for condition monitoring and faults diagnose of rotating machineries. A vision- and fringe pattern-based rotational speed measurement system was proposed to measure the instantaneous rotational speed (IRS) with high accuracy and reliability. A special double-sine-varying-density fringe pattern (DSVD-FP) was designed and pasted around the shaft surface completely and worked as primary angular sensor. The rotational angle could be correctly obtained from the left and right fringe period densities (FPDs) of the DSVD-FP image sequence recorded by a high-speed camera. The instantaneous angular speed (IAS) between two adjacent frames could be calculated from the real-time rotational angle curves, thus, the IRS also could be obtained accurately and efficiently. Both the measurement principle and system design of the novel method have been presented. The influence factors on the sensing characteristics and measurement accuracy of the novel system, including the spectral centrobaric correction method (SCCM) on the FPD calculation, the noise sources introduce by the image sensor, the exposure time and the vibration of the shaft, were investigated through simulations and experiments. The sampling rate of the high speed camera could be up to 5000 Hz, thus, the measurement becomes very fast and the change in rotational speed was sensed within 0.2 ms. The experimental results for different IRS measurements and characterization of the response property of a servo motor demonstrated the high accuracy and fast measurement of the proposed technique, making it attractive for condition monitoring and faults diagnosis of rotating machineries.

Parallel detection experiment of fluorescence confocal microscopy using DMD.

PubMed

Wang, Qingqing; Zheng, Jihong; Wang, Kangni; Gui, Kun; Guo, Hanming; Zhuang, Songlin

2016-05-01

Parallel detection of fluorescence confocal microscopy (PDFCM) system based on Digital Micromirror Device (DMD) is reported in this paper in order to realize simultaneous multi-channel imaging and improve detection speed. DMD is added into PDFCM system, working to take replace of the single traditional pinhole in the confocal system, which divides the laser source into multiple excitation beams. The PDFCM imaging system based on DMD is experimentally set up. The multi-channel image of fluorescence signal of potato cells sample is detected by parallel lateral scanning in order to verify the feasibility of introducing the DMD into fluorescence confocal microscope. In addition, for the purpose of characterizing the microscope, the depth response curve is also acquired. The experimental result shows that in contrast to conventional microscopy, the DMD-based PDFCM system has higher axial resolution and faster detection speed, which may bring some potential benefits in the biology and medicine analysis. SCANNING 38:234-239, 2016. © 2015 Wiley Periodicals, Inc. © Wiley Periodicals, Inc.

Coherent Raman Scattering Microscopy in Biology and Medicine.

PubMed

Zhang, Chi; Zhang, Delong; Cheng, Ji-Xin

2015-01-01

Advancements in coherent Raman scattering (CRS) microscopy have enabled label-free visualization and analysis of functional, endogenous biomolecules in living systems. When compared with spontaneous Raman microscopy, a key advantage of CRS microscopy is the dramatic improvement in imaging speed, which gives rise to real-time vibrational imaging of live biological samples. Using molecular vibrational signatures, recently developed hyperspectral CRS microscopy has improved the readout of chemical information available from CRS images. In this article, we review recent achievements in CRS microscopy, focusing on the theory of the CRS signal-to-noise ratio, imaging speed, technical developments, and applications of CRS imaging in bioscience and clinical settings. In addition, we present possible future directions that the use of this technology may take.

Coherent Raman Scattering Microscopy in Biology and Medicine

PubMed Central

Zhang, Chi; Zhang, Delong; Cheng, Ji-Xin

2016-01-01

Advancements in coherent Raman scattering (CRS) microscopy have enabled label-free visualization and analysis of functional, endogenous biomolecules in living systems. When compared with spontaneous Raman microscopy, a key advantage of CRS microscopy is the dramatic improvement in imaging speed, which gives rise to real-time vibrational imaging of live biological samples. Using molecular vibrational signatures, recently developed hyperspectral CRS microscopy has improved the readout of chemical information available from CRS images. In this article, we review recent achievements in CRS microscopy, focusing on the theory of the CRS signal-to-noise ratio, imaging speed, technical developments, and applications of CRS imaging in bioscience and clinical settings. In addition, we present possible future directions that the use of this technology may take. PMID:26514285

Improvements in Speed and Functionality of a 670-GHz Imaging Radar

NASA Technical Reports Server (NTRS)

Dengler, Robert J.; Cooper, Ken B.; Mehdi, Imran; Siegel, Peter H.; Tarsala, Jan A.; Bryllert, Thomas E.

2011-01-01

Significant improvements have been made in the instrument originally described in a prior NASA Tech Briefs article: Improved Speed and Functionality of a 580-GHz Imaging Radar (NPO-45156), Vol. 34, No. 7 (July 2010), p. 51. First, the wideband YIG oscillator has been replaced with a JPL-designed and built phase-locked, low-noise chirp source. Second, further refinements to the data acquisition and signal processing software have been performed by moving critical code sections to C code, and compiling those sections to Windows DLLs, which are then invoked from the main LabVIEW executive. This system is an active, single-pixel scanned imager operating at 670 GHz. The actual chirp signals for the RF and LO chains were generated by a pair of MITEQ 2.5 3.3 GHz chirp sources. Agilent benchtop synthesizers operating at fixed frequencies around 13 GHz were then used to up-convert the chirp sources to 15.5 16.3 GHz. The resulting signals were then multiplied 36 times by a combination of off-the-shelf millimeter- wave components, and JPL-built 200- GHz doublers and 300- and 600-GHz triplers. The power required to drive the submillimeter-wave multipliers was provided by JPL-built W-band amplifiers. The receive and transmit signal paths were combined using a thin, high-resistivity silicon wafer as a beam splitter. While the results at present are encouraging, the system still lacks sufficient speed to be usable for practical applications in a contraband detection. Ideally, an image acquisition speed of ten seconds, or a factor of 30 improvement, is desired. However, the system improvements to date have resulted in a factor of five increase in signal acquisition speed, as well as enhanced signal processing algorithms, permitting clearer imaging of contraband objects hidden underneath clothing. In particular, advances in three distinct areas have enabled these performance enhancements: base source phase noise reduction, chirp rate, and signal processing. Additionally, a second pixel was added, automatically reducing the imaging time by a factor of two. Although adding a second pixel to the system doubles the amount of submillimeter components required, some savings in microwave hardware can be realized by using a common low-noise source.

Fluorescence Microscopy Gets Faster and Clearer: Roles of Photochemistry and Selective Illumination

PubMed Central

Wolenski, Joseph S.; Julich, Doerthe

2014-01-01

Significant advances in fluorescence microscopy tend be a balance between two competing qualities wherein improvements in resolution and low light detection are typically accompanied by losses in acquisition rate and signal-to-noise, respectively. These trade-offs are becoming less of a barrier to biomedical research as recent advances in optoelectronic microscopy and developments in fluorophore chemistry have enabled scientists to see beyond the diffraction barrier, image deeper into live specimens, and acquire images at unprecedented speed. Selective plane illumination microscopy has provided significant gains in the spatial and temporal acquisition of fluorescence specimens several mm in thickness. With commercial systems now available, this method promises to expand on recent advances in 2-photon deep-tissue imaging with improved speed and reduced photobleaching compared to laser scanning confocal microscopy. Superresolution microscopes are also available in several modalities and can be coupled with selective plane illumination techniques. The combination of methods to increase resolution, acquisition speed, and depth of collection are now being married to common microscope systems, enabling scientists to make significant advances in live cell and in situ imaging in real time. We show that light sheet microscopy provides significant advantages for imaging live zebrafish embryos compared to laser scanning confocal microscopy. PMID:24600334

Development of Wind Speed Retrieval from Cross-Polarization Chinese Gaofen-3 Synthetic Aperture Radar in Typhoons

PubMed Central

Yuan, Xinzhe; Sun, Jian; Zhou, Wei; Zhang, Qingjun

2018-01-01

The purpose of our work is to determine the feasibility and effectiveness of retrieving sea surface wind speeds from C-band cross-polarization (herein vertical-horizontal, VH) Chinese Gaofen-3 (GF-3) SAR images in typhoons. In this study, we have collected three GF-3 SAR images acquired in Global Observation (GLO) and Wide ScanSAR (WSC) mode during the summer of 2017 from the China Sea, which includes the typhoons Noru, Doksuri and Talim. These images were collocated with wind simulations at 0.12° grids from a numeric model, called the Regional Assimilation and Prediction System-Typhoon model (GRAPES-TYM). Recent research shows that GRAPES-TYM has a good performance for typhoon simulation in the China Sea. Based on the dataset, the dependence of wind speed and of radar incidence angle on normalized radar cross (NRCS) of VH-polarization GF-3 SAR have been investigated, after which an empirical algorithm for wind speed retrieval from VH-polarization GF-3 SAR was tuned. An additional four VH-polarization GF-3 SAR images in three typhoons, Noru, Hato and Talim, were investigated in order to validate the proposed algorithm. SAR-derived winds were compared with measurements from Windsat winds at 0.25° grids with wind speeds up to 40 m/s, showing a 5.5 m/s root mean square error (RMSE) of wind speed and an improved RMSE of 5.1 m/s wind speed was achieved compared with the retrieval results validated against GRAPES-TYM winds. It is concluded that the proposed algorithm is a promising potential technique for strong wind retrieval from cross-polarization GF-3 SAR images without encountering a signal saturation problem. PMID:29385068

Low-Speed Fingerprint Image Capture System User`s Guide, June 1, 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Whitus, B.R.; Goddard, J.S.; Jatko, W.B.

1993-06-01

The Low-Speed Fingerprint Image Capture System (LS-FICS) uses a Sun workstation controlling a Lenzar ElectroOptics Opacity 1000 imaging system to digitize fingerprint card images to support the Federal Bureau of Investigation`s (FBI`s) Automated Fingerprint Identification System (AFIS) program. The system also supports the operations performed by the Oak Ridge National Laboratory- (ORNL-) developed Image Transmission Network (ITN) prototype card scanning system. The input to the system is a single FBI fingerprint card of the agreed-upon standard format and a user-specified identification number. The output is a file formatted to be compatible with the National Institute of Standards and Technology (NIST)more » draft standard for fingerprint data exchange dated June 10, 1992. These NIST compatible files contain the required print and text images. The LS-FICS is designed to provide the FBI with the capability of scanning fingerprint cards into a digital format. The FBI will replicate the system to generate a data base of test images. The Host Workstation contains the image data paths and the compression algorithm. A local area network interface, disk storage, and tape drive are used for the image storage and retrieval, and the Lenzar Opacity 1000 scanner is used to acquire the image. The scanner is capable of resolving 500 pixels/in. in both x and y directions. The print images are maintained in full 8-bit gray scale and compressed with an FBI-approved wavelet-based compression algorithm. The text fields are downsampled to 250 pixels/in. and 2-bit gray scale. The text images are then compressed using a lossless Huffman coding scheme. The text fields retrieved from the output files are easily interpreted when displayed on the screen. Detailed procedures are provided for system calibration and operation. Software tools are provided to verify proper system operation.« less

SU-E-J-28: Gantry Speed Significantly Affects Image Quality and Imaging Dose for 4D Cone-Beam Computed Tomography On the Varian Edge Platform

DOE Office of Scientific and Technical Information (OSTI.GOV)

Santoso, A; Song, K; Gardner, S

Purpose: 4D-CBCT facilitates assessment of tumor motion at treatment position. We investigated the effect of gantry speed on 4D-CBCT image quality and dose using the Varian Edge On-Board Imager (OBI). Methods: A thoracic protocol was designed using a 125 kVp spectrum. Image quality parameters were obtained via 4D acquisition using a Catphan phantom with a gating system. A sinusoidal waveform was executed with a five second period and superior-inferior motion. 4D-CBCT scans were sorted into 4 and 10 phases. Image quality metrics included spatial resolution, contrast-to-noise ratio (CNR), uniformity index (UI), Hounsfield unit (HU) sensitivity, and RMS error (RMSE) ofmore » motion amplitude. Dosimetry was accomplished using Gafchromic XR-QA2 films within a CIRS Thorax phantom. This was placed on the gating phantom using the same motion waveform. Results: High contrast resolution decreased linearly from 5.93 to 4.18 lp/cm, 6.54 to 4.18 lp/cm, and 5.19 to 3.91 lp/cm for averaged, 4 phase, and 10 phase 4DCBCT volumes respectively as gantry speed increased from 1.0 to 6.0 degs/sec. CNRs decreased linearly from 4.80 to 1.82 as the gantry speed increased from 1.0 to 6.0 degs/sec, respectively. No significant variations in UIs, HU sensitivities, or RMSEs were observed with variable gantry speed. Ion chamber measurements compared to film yielded small percent differences in plastic water regions (0.1–9.6%), larger percent differences in lung equivalent regions (7.5–34.8%), and significantly larger percent differences in bone equivalent regions (119.1–137.3%). Ion chamber measurements decreased from 17.29 to 2.89 cGy with increasing gantry speed from 1.0 to 6.0 degs/sec. Conclusion: Maintaining technique factors while changing gantry speed changes the number of projections used for reconstruction. Increasing the number of projections by decreasing gantry speed decreases noise, however, dose is increased. The future of 4DCBCT’s clinical utility relies on further investigation of image optimization.« less

Interferometric imaging of acoustical phenomena using high-speed polarization camera and 4-step parallel phase-shifting technique

NASA Astrophysics Data System (ADS)

Ishikawa, K.; Yatabe, K.; Ikeda, Y.; Oikawa, Y.; Onuma, T.; Niwa, H.; Yoshii, M.

2017-02-01

Imaging of sound aids the understanding of the acoustical phenomena such as propagation, reflection, and diffraction, which is strongly required for various acoustical applications. The imaging of sound is commonly done by using a microphone array, whereas optical methods have recently been interested due to its contactless nature. The optical measurement of sound utilizes the phase modulation of light caused by sound. Since light propagated through a sound field changes its phase as proportional to the sound pressure, optical phase measurement technique can be used for the sound measurement. Several methods including laser Doppler vibrometry and Schlieren method have been proposed for that purpose. However, the sensitivities of the methods become lower as a frequency of sound decreases. In contrast, since the sensitivities of the phase-shifting technique do not depend on the frequencies of sounds, that technique is suitable for the imaging of sounds in the low-frequency range. The principle of imaging of sound using parallel phase-shifting interferometry was reported by the authors (K. Ishikawa et al., Optics Express, 2016). The measurement system consists of a high-speed polarization camera made by Photron Ltd., and a polarization interferometer. This paper reviews the principle briefly and demonstrates the high-speed imaging of acoustical phenomena. The results suggest that the proposed system can be applied to various industrial problems in acoustical engineering.

High-speed digital holography for neutral gas and electron density imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Granstedt, E. M., E-mail: egranstedt@gmail.com; Thomas, C. E.; Kaita, R.

2016-05-15

An instrument was developed using digital holographic reconstruction of the wavefront from a CO{sub 2} laser imaged on a high-speed commercial IR camera. An acousto-optic modulator is used to generate 1–25 μs pulses from a continuous-wave CO{sub 2} laser, both to limit the average power at the detector and also to freeze motion from sub-interframe time scales. Extensive effort was made to characterize and eliminate noise from vibrations and second-surface reflections. Mismatch of the reference and object beam curvature initially contributed substantially to vibrational noise, but was mitigated through careful positioning of identical imaging lenses. Vibrational mode amplitudes were successfullymore » reduced to ≲1 nm for frequencies ≳50 Hz, and the inter-frame noise across the 128 × 128 pixel window which is typically used is ≲2.5 nm. To demonstrate the capabilities of the system, a piezo-electric valve and a reducing-expanding nozzle were used to generate a super-sonic gas jet which was imaged with high spatial resolution (better than 0.8 lp/mm) at high speed. Abel inversions were performed on the phase images to produce 2-D images of localized gas density. This system could also be used for high spatial and temporal resolution measurements of plasma electron density or surface deformations.« less

CCD high-speed videography system with new concepts and techniques

NASA Astrophysics Data System (ADS)

Zheng, Zengrong; Zhao, Wenyi; Wu, Zhiqiang

1997-05-01

A novel CCD high speed videography system with brand-new concepts and techniques is developed by Zhejiang University recently. The system can send a series of short flash pulses to the moving object. All of the parameters, such as flash numbers, flash durations, flash intervals, flash intensities and flash colors, can be controlled according to needs by the computer. A series of moving object images frozen by flash pulses, carried information of moving object, are recorded by a CCD video camera, and result images are sent to a computer to be frozen, recognized and processed with special hardware and software. Obtained parameters can be displayed, output as remote controlling signals or written into CD. The highest videography frequency is 30,000 images per second. The shortest image freezing time is several microseconds. The system has been applied to wide fields of energy, chemistry, medicine, biological engineering, aero- dynamics, explosion, multi-phase flow, mechanics, vibration, athletic training, weapon development and national defense engineering. It can also be used in production streamline to carry out the online, real-time monitoring and controlling.

Improvements in High Speed, High Resolution Dynamic Digital Image Correlation for Experimental Evaluation of Composite Drive System Components

NASA Technical Reports Server (NTRS)

Kohlman, Lee W.; Ruggeri, Charles R.; Roberts, Gary D.; Handschuh, Robert Frederick

2013-01-01

Composite materials have the potential to reduce the weight of rotating drive system components. However, these components are more complex to design and evaluate than static structural components in part because of limited ability to acquire deformation and failure initiation data during dynamic tests. Digital image correlation (DIC) methods have been developed to provide precise measurements of deformation and failure initiation for material test coupons and for structures under quasi-static loading. Attempts to use the same methods for rotating components (presented at the AHS International 68th Annual Forum in 2012) are limited by high speed camera resolution, image blur, and heating of the structure by high intensity lighting. Several improvements have been made to the system resulting in higher spatial resolution, decreased image noise, and elimination of heating effects. These improvements include the use of a high intensity synchronous microsecond pulsed LED lighting system, different lenses, and changes in camera configuration. With these improvements, deformation measurements can be made during rotating component tests with resolution comparable to that which can be achieved in static tests

Improvements in High Speed, High Resolution Dynamic Digital Image Correlation for Experimental Evaluation of Composite Drive System Components

NASA Technical Reports Server (NTRS)

Kohlman, Lee; Ruggeri, Charles; Roberts, Gary; Handshuh, Robert

2013-01-01

Composite materials have the potential to reduce the weight of rotating drive system components. However, these components are more complex to design and evaluate than static structural components in part because of limited ability to acquire deformation and failure initiation data during dynamic tests. Digital image correlation (DIC) methods have been developed to provide precise measurements of deformation and failure initiation for material test coupons and for structures under quasi-static loading. Attempts to use the same methods for rotating components (presented at the AHS International 68th Annual Forum in 2012) are limited by high speed camera resolution, image blur, and heating of the structure by high intensity lighting. Several improvements have been made to the system resulting in higher spatial resolution, decreased image noise, and elimination of heating effects. These improvements include the use of a high intensity synchronous microsecond pulsed LED lighting system, different lenses, and changes in camera configuration. With these improvements, deformation measurements can be made during rotating component tests with resolution comparable to that which can be achieved in static tests.

Long-Wavelength Beam Steerer Based on a Micro-Electromechanical Mirror

PubMed Central

Kos, Anthony B; Gerecht, Eyal

2013-01-01

Commercially available mirrors for scanning long-wavelength beams are too large for high-speed imaging. There is a need for a smaller, more agile pointing apparatus to provide images in seconds, not minutes or hours. A fast long-wavelength beam steerer uses a commercial micro-electro-mechanical system (MEMS) mirror controlled by a high-performance digital signal processor (DSP). The DSP allows high-speed raster scanning of the incident radiation, which is focused to a small waist onto the 9mm2, gold-coated, MEMS mirror surface, while simultaneously acquiring an undistorted, high spatial-resolution image of an object. The beam steerer hardware, software and performance are described. The system can also serve as a miniaturized, high-performance long-wavelength beam chopper for lock-in detection. PMID:26401426

A Highly Accurate Face Recognition System Using Filtering Correlation

NASA Astrophysics Data System (ADS)

Watanabe, Eriko; Ishikawa, Sayuri; Kodate, Kashiko

2007-09-01

The authors previously constructed a highly accurate fast face recognition optical correlator (FARCO) [E. Watanabe and K. Kodate: Opt. Rev. 12 (2005) 460], and subsequently developed an improved, super high-speed FARCO (S-FARCO), which is able to process several hundred thousand frames per second. The principal advantage of our new system is its wide applicability to any correlation scheme. Three different configurations were proposed, each depending on correlation speed. This paper describes and evaluates a software correlation filter. The face recognition function proved highly accurate, seeing that a low-resolution facial image size (64 × 64 pixels) has been successfully implemented. An operation speed of less than 10 ms was achieved using a personal computer with a central processing unit (CPU) of 3 GHz and 2 GB memory. When we applied the software correlation filter to a high-security cellular phone face recognition system, experiments on 30 female students over a period of three months yielded low error rates: 0% false acceptance rate and 2% false rejection rate. Therefore, the filtering correlation works effectively when applied to low resolution images such as web-based images or faces captured by a monitoring camera.

Video-rate or high-precision: a flexible range imaging camera

NASA Astrophysics Data System (ADS)

Dorrington, Adrian A.; Cree, Michael J.; Carnegie, Dale A.; Payne, Andrew D.; Conroy, Richard M.; Godbaz, John P.; Jongenelen, Adrian P. P.

2008-02-01

A range imaging camera produces an output similar to a digital photograph, but every pixel in the image contains distance information as well as intensity. This is useful for measuring the shape, size and location of objects in a scene, hence is well suited to certain machine vision applications. Previously we demonstrated a heterodyne range imaging system operating in a relatively high resolution (512-by-512) pixels and high precision (0.4 mm best case) configuration, but with a slow measurement rate (one every 10 s). Although this high precision range imaging is useful for some applications, the low acquisition speed is limiting in many situations. The system's frame rate and length of acquisition is fully configurable in software, which means the measurement rate can be increased by compromising precision and image resolution. In this paper we demonstrate the flexibility of our range imaging system by showing examples of high precision ranging at slow acquisition speeds and video-rate ranging with reduced ranging precision and image resolution. We also show that the heterodyne approach and the use of more than four samples per beat cycle provides better linearity than the traditional homodyne quadrature detection approach. Finally, we comment on practical issues of frame rate and beat signal frequency selection.

High resolution image processing on low-cost microcomputers

NASA Technical Reports Server (NTRS)

Miller, R. L.

1993-01-01

Recent advances in microcomputer technology have resulted in systems that rival the speed, storage, and display capabilities of traditionally larger machines. Low-cost microcomputers can provide a powerful environment for image processing. A new software program which offers sophisticated image display and analysis on IBM-based systems is presented. Designed specifically for a microcomputer, this program provides a wide-range of functions normally found only on dedicated graphics systems, and therefore can provide most students, universities and research groups with an affordable computer platform for processing digital images. The processing of AVHRR images within this environment is presented as an example.

International Congress on High-Speed Photography and Photonics, 19th, Cambridge, England, Sept. 16-21, 1990, Proceedings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garfield, B.R.; Rendell, J.T.

1991-01-01

The present conference discusses the application of schlieren photography in industry, laser fiber-optic high speed photography, holographic visualization of hypervelocity explosions, sub-100-picosec X-ray grating cameras, flash soft X-radiography, a novel approach to synchroballistic photography, a programmable image converter framing camera, high speed readout CCDs, an ultrafast optomechanical camera, a femtosec streak tube, a modular streak camera for laser ranging, and human-movement analysis with real-time imaging. Also discussed are high-speed photography of high-resolution moire patterns, a 2D electron-bombarded CCD readout for picosec electrooptical data, laser-generated plasma X-ray diagnostics, 3D shape restoration with virtual grating phase detection, Cu vapor lasers for highmore » speed photography, a two-frequency picosec laser with electrooptical feedback, the conversion of schlieren systems to high speed interferometers, laser-induced cavitation bubbles, stereo holographic cinematography, a gatable photonic detector, and laser generation of Stoneley waves at liquid-solid boundaries.« less

Lipid detection by intravascular photoacoustic imaging with flexible catheter at 20 fps (Conference Presentation)

NASA Astrophysics Data System (ADS)

Wu, Min; Daeichin, Verya; Springeling, Geert; van der Steen, Antonius F. W.; van Soest, Gijs

2016-02-01

Intravascular Photoacoustic (IVPA) imaging is a promising new technology to assess lipid content of coronary atherosclerotic plaque, an important determinant of the risk associated with the plaque triggering a heart attack. Clinical translation of IVPA imaging requires real-time image acquisition, which has been a technological challenge. In this work, we demonstrate a high-speed, dual-wavelength IVPA imaging system at 1.7 µm wavelength, operating with a flexible catheter of 1.2 mm outer diameter (including outer sheath). The catheter was custom designed and fabricated, and used a 40 MHz transducer for intravascular ultrasound (IVUS) and IVPA imaging. The optical excitation is provided by a dual OPO system, pumped by CW diode-pumped Q-switched Nd:YAG lasers, with a repetition rate of 5 kHz. Each OPO can be tuned to a custom wavelength between 1690 and 1750 nm; two wavelengths only are needed to discriminate between plaque lipids and adipose tissue. The pulse energy is about 80 µJ. We tested the imaging performance of the presented system in a polyvinyl-alcohol (PVA) vessel mimicking phantom and human coronary arteries ex vivo. IVPA identified lipid deposits inside atherosclerotic plaque, while IVUS showed tissue structure. We demonstrated IVPA imaging at a speed of 20 frames per second, with 250 A-scans per frame. This is significantly faster than previous IVPA imaging systems, and will enable the translation of IVPA imaging into clinical practice.

Development of a prototype of the tele-localisation system in radiotherapy using personal digital assistant via wireless communication.

PubMed

Wu, Vincent Wing-Cheung; Tang, Fuk-hay; Cheung, Wai-kwan; Chan, Kit-chi

2013-02-01

In localisation of radiotherapy treatment field, the oncologist is present at the simulator to approve treatment details produced by the therapist. Problems may arise if the oncologist is not available and the patient requires urgent treatment. The development of a tele-localisation system is a potential solution, where the oncologist uses a personal digital assistant (PDA) to localise the treatment field on the image sent from the simulator through wireless communication and returns the information to the therapist after his or her approval. Our team developed the first tele-localisation prototype, which consisted of a server workstation (simulator) for the administration of digital imaging and communication in medicine localisation images including viewing and communication with the PDA via a Wi-Fi network; a PDA (oncologist's site) installed with the custom-built programme that synchronises with the server workstation and performs treatment field editing. Trial tests on accuracy and speed of the prototype system were conducted on 30 subjects with the treatment regions covering the neck, skull, chest and pelvis. The average time required in performing the localisation using the PDA was less than 1.5 min, with the blocked field longer than the open field. The transmission speed of the four treatment regions was similar. The average physical distortion of the images was within 4.4% and the accuracy of field size indication was within 5.3%. Compared with the manual method, the tele-localisation system presented with an average deviation of 5.5%. The prototype system fulfilled the planned objectives of tele-localisation procedure with reasonable speed and accuracy. © 2012 The Authors. Journal of Medical Imaging and Radiation Oncology © 2012 The Royal Australian and New Zealand College of Radiologists.

Grayscale image segmentation for real-time traffic sign recognition: the hardware point of view

NASA Astrophysics Data System (ADS)

Cao, Tam P.; Deng, Guang; Elton, Darrell

2009-02-01

In this paper, we study several grayscale-based image segmentation methods for real-time road sign recognition applications on an FPGA hardware platform. The performance of different image segmentation algorithms in different lighting conditions are initially compared using PC simulation. Based on these results and analysis, suitable algorithms are implemented and tested on a real-time FPGA speed sign detection system. Experimental results show that the system using segmented images uses significantly less hardware resources on an FPGA while maintaining comparable system's performance. The system is capable of processing 60 live video frames per second.

Performance comparison between 8 and 14 bit-depth imaging in polarization-sensitive swept-source optical coherence tomography

NASA Astrophysics Data System (ADS)

Lu, Zenghai; Kasaragoda, Deepa K.; Matcher, Stephen J.

2011-03-01

We compare true 8 and 14 bit-depth imaging of SS-OCT and polarization-sensitive SS-OCT (PS-SS-OCT) at 1.3μm wavelength by using two hardware-synchronized high-speed data acquisition (DAQ) boards. The two DAQ boards read exactly the same imaging data for comparison. The measured system sensitivity at 8-bit depth is comparable to that for 14-bit acquisition when using the more sensitive of the available full analog input voltage ranges of the ADC. Ex-vivo structural and birefringence images of an equine tendon sample indicate no significant differences between images acquired by the two DAQ boards suggesting that 8-bit DAQ boards can be employed to increase imaging speeds and reduce storage in clinical SS-OCT/PS-SS-OCT systems. We also compare the resulting image quality when the image data sampled with the 14-bit DAQ from human finger skin is artificially bit-reduced during post-processing. However, in agreement with the results reported previously, we also observe that in our system that real-world 8-bit image shows more artifacts than the image acquired by numerically truncating to 8-bits from the raw 14-bit image data, especially in low intensity image area. This is due to the higher noise floor and reduced dynamic range of the 8-bit DAQ. One possible disadvantage is a reduced imaging dynamic range which can manifest itself as an increase in image artefacts due to strong Fresnel reflection.

Microscope-integrated optical coherence tomography for image-aided positioning of glaucoma surgery

NASA Astrophysics Data System (ADS)

Li, Xiqi; Wei, Ling; Dong, Xuechuan; Huang, Ping; Zhang, Chun; He, Yi; Shi, Guohua; Zhang, Yudong

2015-07-01

Most glaucoma surgeries involve creating new aqueous outflow pathways with the use of a small surgical instrument. This article reported a microscope-integrated, real-time, high-speed, swept-source optical coherence tomography system (SS-OCT) with a 1310-nm light source for glaucoma surgery. A special mechanism was designed to produce an adjustable system suitable for use in surgery. A two-graphic processing unit architecture was used to speed up the data processing and real-time volumetric rendering. The position of the surgical instrument can be monitored and measured using the microscope and a grid-inserted image of the SS-OCT. Finally, experiments were simulated to assess the effectiveness of this integrated system. Experimental results show that this system is a suitable positioning tool for glaucoma surgery.

Recent advances in Optical Computed Tomography (OCT) imaging system for three dimensional (3D) radiotherapy dosimetry

NASA Astrophysics Data System (ADS)

Rahman, Ahmad Taufek Abdul; Farah Rosli, Nurul; Zain, Shafirah Mohd; Zin, Hafiz M.

2018-01-01

Radiotherapy delivery techniques for cancer treatment are becoming more complex and highly focused, to enable accurate radiation dose delivery to the cancerous tissue and minimum dose to the healthy tissue adjacent to tumour. Instrument to verify the complex dose delivery in radiotherapy such as optical computed tomography (OCT) measures the dose from a three-dimensional (3D) radiochromic dosimeter to ensure the accuracy of the radiotherapy beam delivery to the patient. OCT measures the optical density in radiochromic material that changes predictably upon exposure to radiotherapy beams. OCT systems have been developed using a photodiode and charged coupled device (CCD) as the detector. The existing OCT imaging systems have limitation in terms of the accuracy and the speed of the measurement. Advances in on-pixel intelligence CMOS image sensor (CIS) will be exploited in this work to replace current detector in OCT imaging systems. CIS is capable of on-pixel signal processing at a very fast imaging speed (over several hundred images per second) that will allow improvement in the 3D measurement of the optical density. The paper will review 3D radiochromic dosimeters and OCT systems developed and discuss how CMOS based OCT imaging will provide accurate and fast optical density measurements in 3D. The paper will also discuss the configuration of the CMOS based OCT developed in this work and how it may improve the existing OCT system.

Radiology on handheld devices: image display, manipulation, and PACS integration issues.

PubMed

Raman, Bhargav; Raman, Raghav; Raman, Lalithakala; Beaulieu, Christopher F

2004-01-01

Handheld personal digital assistants (PDAs) have undergone continuous and substantial improvements in hardware and graphics capabilities, making them a compelling platform for novel developments in teleradiology. The latest PDAs have processor speeds of up to 400 MHz and storage capacities of up to 80 Gbytes with memory expansion methods. A Digital Imaging and Communications in Medicine (DICOM)-compliant, vendor-independent handheld image access system was developed in which a PDA server acts as the gateway between a picture archiving and communication system (PACS) and PDAs. The system is compatible with most currently available PDA models. It is capable of both wired and wireless transfer of images and includes custom PDA software and World Wide Web interfaces that implement a variety of basic image manipulation functions. Implementation of this system, which is currently undergoing debugging and beta testing, required optimization of the user interface to efficiently display images on smaller PDA screens. The PDA server manages user work lists and implements compression and security features to accelerate transfer speeds, protect patient information, and regulate access. Although some limitations remain, PDA-based teleradiology has the potential to increase the efficiency of the radiologic work flow, increasing productivity and improving communication with referring physicians and patients. Copyright RSNA, 2004

Research based on the SoPC platform of feature-based image registration

NASA Astrophysics Data System (ADS)

Shi, Yue-dong; Wang, Zhi-hui

2015-12-01

This paper focuses on the study of implementing feature-based image registration by System on a Programmable Chip (SoPC) hardware platform. We solidify the image registration algorithm on the FPGA chip, in which embedded soft core processor Nios II can speed up the image processing system. In this way, we can make image registration technology get rid of the PC. And, consequently, this kind of technology will be got an extensive use. The experiment result indicates that our system shows stable performance, particularly in terms of matching processing which noise immunity is good. And feature points of images show a reasonable distribution.

Development of High-Speed Fluorescent X-Ray Micro-Computed Tomography

NASA Astrophysics Data System (ADS)

Takeda, T.; Tsuchiya, Y.; Kuroe, T.; Zeniya, T.; Wu, J.; Lwin, Thet-Thet; Yashiro, T.; Yuasa, T.; Hyodo, K.; Matsumura, K.; Dilmanian, F. A.; Itai, Y.; Akatsuka, T.

2004-05-01

A high-speed fluorescent x-ray CT (FXCT) system using monochromatic synchrotron x rays was developed to detect very low concentration of medium-Z elements for biomedical use. The system is equipped two types of high purity germanium detectors, and fast electronics and software. Preliminary images of a 10mm diameter plastic phantom containing channels field with iodine solutions of different concentrations showed a minimum detection level of 0.002 mg I/ml at an in-plane spatial resolution of 100μm. Furthermore, the acquisition time was reduced about 1/2 comparing to previous system. The results indicate that FXCT is a highly sensitive imaging modality capable of detecting very low concentration of iodine, and that the method has potential in biomedical applications.

Vocal fold vibrations: high-speed imaging, kymography, and acoustic analysis: a preliminary report.

PubMed

Larsson, H; Hertegård, S; Lindestad, P A; Hammarberg, B

2000-12-01

To evaluate a new analysis system, High-Speed Tool Box (H. Larsson, custom-made program for image analysis, version 1.1, Department of Logopedics and Phoniatrics, Huddinge University Hospital, Huddinge, Sweden, 1998) for studying vocal fold vibrations using a high-speed camera and to relate findings from these analyses to sound characteristics. A Weinberger Speedcam + 500 system (Weinberger AG, Dietikon, Switzerland) was used with a frame rate of 1,904 frames per second. Images were stored and analyzed digitally. Analysis included automatic glottal edge detection and calculation of glottal area variations, as well as kymography. These signals were compared with acoustic waveforms using the Soundswell program (Hitech Development AB, Stockholm, Sweden). The High-Speed Tool Box was applied on two types of high-speed recordings: a diplophonic phonation and a tremor voice. Relations between glottal vibratory patterns and the sound waveform were analyzed. In the diplophonic phonation, the glottal area waveform, as well as the kymogram, showed a specific pattern of repetitive glottal closures, which was also seen in the acoustic waveform. In the tremor voice, fundamental frequency (F0) fluctuations in the acoustic waveform were reflected in slow variations in amplitude in the glottal area waveform. For studying details of mucosal movements during these kinds of abnormal vibrations, the glottal area waveform was particularly useful. Our results suggest that this combined high-speed acoustic-kymographic analysis package is a promising aid for separating and specifying different voice qualities such as diplophonia and voice tremor. Apart from clinical use, this finding should be of help for specification of the terminology of different voice qualities.

High-speed railway real-time localization auxiliary method based on deep neural network

NASA Astrophysics Data System (ADS)

Chen, Dongjie; Zhang, Wensheng; Yang, Yang

2017-11-01

High-speed railway intelligent monitoring and management system is composed of schedule integration, geographic information, location services, and data mining technology for integration of time and space data. Assistant localization is a significant submodule of the intelligent monitoring system. In practical application, the general access is to capture the image sequences of the components by using a high-definition camera, digital image processing technique and target detection, tracking and even behavior analysis method. In this paper, we present an end-to-end character recognition method based on a deep CNN network called YOLO-toc for high-speed railway pillar plate number. Different from other deep CNNs, YOLO-toc is an end-to-end multi-target detection framework, furthermore, it exhibits a state-of-art performance on real-time detection with a nearly 50fps achieved on GPU (GTX960). Finally, we realize a real-time but high-accuracy pillar plate number recognition system and integrate natural scene OCR into a dedicated classification YOLO-toc model.

Research of flaw image collecting and processing technology based on multi-baseline stereo imaging

NASA Astrophysics Data System (ADS)

Yao, Yong; Zhao, Jiguang; Pang, Xiaoyan

2008-03-01

Aiming at the practical situations such as accurate optimal design, complex algorithms and precise technical demands of gun bore flaw image collecting, the design frame of a 3-D image collecting and processing system based on multi-baseline stereo imaging was presented in this paper. This system mainly including computer, electrical control box, stepping motor and CCD camera and it can realize function of image collection, stereo matching, 3-D information reconstruction and after-treatments etc. Proved by theoretical analysis and experiment results, images collected by this system were precise and it can slake efficiently the uncertainty problem produced by universally veins or repeated veins. In the same time, this system has faster measure speed and upper measure precision.

High-speed high-resolution epifluorescence imaging system using CCD sensor and digital storage for neurobiological research

NASA Astrophysics Data System (ADS)

Takashima, Ichiro; Kajiwara, Riichi; Murano, Kiyo; Iijima, Toshio; Morinaka, Yasuhiro; Komobuchi, Hiroyoshi

2001-04-01

We have designed and built a high-speed CCD imaging system for monitoring neural activity in an exposed animal cortex stained with a voltage-sensitive dye. Two types of custom-made CCD sensors were developed for this system. The type I chip has a resolution of 2664 (H) X 1200 (V) pixels and a wide imaging area of 28.1 X 13.8 mm, while the type II chip has 1776 X 1626 pixels and an active imaging area of 20.4 X 18.7 mm. The CCD arrays were constructed with multiple output amplifiers in order to accelerate the readout rate. The two chips were divided into either 24 (I) or 16 (II) distinct areas that were driven in parallel. The parallel CCD outputs were digitized by 12-bit A/D converters and then stored in the frame memory. The frame memory was constructed with synchronous DRAM modules, which provided a capacity of 128 MB per channel. On-chip and on-memory binning methods were incorporated into the system, e.g., this enabled us to capture 444 X 200 pixel-images for periods of 36 seconds at a rate of 500 frames/second. This system was successfully used to visualize neural activity in the cortices of rats, guinea pigs, and monkeys.

Quality Assurance By Laser Scanning And Imaging Techniques

NASA Astrophysics Data System (ADS)

SchmalfuB, Harald J.; Schinner, Karl Ludwig

1989-03-01

Laser scanning systems are well established in the world of fast industrial in-process quality inspection systems. The materials inspected by laser scanning systems are e.g. "endless" sheets of steel, paper, textile, film or foils. The web width varies from 50 mm up to 5000 mm or more. The web speed depends strongly on the production process and can reach several hundred meters per minute. The continuous data flow in one of different channels of the optical receiving system exceeds ten Megapixels/sec. Therefore it is clear that the electronic evaluation system has to process these data streams in real time and no image storage is possible. But sometimes (e.g. first installation of the system, change of the defect classification) it would be very helpful to have the possibility for a visual look on the original, i.e. not processed sensor data. At first we show the principle set up of a standard laser scanning system. Then we will introduce a large image memory especially designed for the needs of high-speed inspection sensors. This image memory co-operates with the standard on-line evaluation electronics and provides therefore an easy comparison between processed and non-processed data. We will discuss the basic system structure and we will show the first industrial results.

Coincidence ion imaging with a fast frame camera

NASA Astrophysics Data System (ADS)

Lee, Suk Kyoung; Cudry, Fadia; Lin, Yun Fei; Lingenfelter, Steven; Winney, Alexander H.; Fan, Lin; Li, Wen

2014-12-01

A new time- and position-sensitive particle detection system based on a fast frame CMOS (complementary metal-oxide semiconductors) camera is developed for coincidence ion imaging. The system is composed of four major components: a conventional microchannel plate/phosphor screen ion imager, a fast frame CMOS camera, a single anode photomultiplier tube (PMT), and a high-speed digitizer. The system collects the positional information of ions from a fast frame camera through real-time centroiding while the arrival times are obtained from the timing signal of a PMT processed by a high-speed digitizer. Multi-hit capability is achieved by correlating the intensity of ion spots on each camera frame with the peak heights on the corresponding time-of-flight spectrum of a PMT. Efficient computer algorithms are developed to process camera frames and digitizer traces in real-time at 1 kHz laser repetition rate. We demonstrate the capability of this system by detecting a momentum-matched co-fragments pair (methyl and iodine cations) produced from strong field dissociative double ionization of methyl iodide.

Anatomically correct visualization of the human upper airway using a high-speed long range optical coherence tomography system with an integrated positioning sensor

NASA Astrophysics Data System (ADS)

Jing, Joseph C.; Chou, Lidek; Su, Erica; Wong, Brian J. F.; Chen, Zhongping

2016-12-01

The upper airway is a complex tissue structure that is prone to collapse. Current methods for studying airway obstruction are inadequate in safety, cost, or availability, such as CT or MRI, or only provide localized qualitative information such as flexible endoscopy. Long range optical coherence tomography (OCT) has been used to visualize the human airway in vivo, however the limited imaging range has prevented full delineation of the various shapes and sizes of the lumen. We present a new long range OCT system that integrates high speed imaging with a real-time position tracker to allow for the acquisition of an accurate 3D anatomical structure in vivo. The new system can achieve an imaging range of 30 mm at a frame rate of 200 Hz. The system is capable of generating a rapid and complete visualization and quantification of the airway, which can then be used in computational simulations to determine obstruction sites.

Development and application of a particle image velocimeter for high-speed flows

NASA Astrophysics Data System (ADS)

Molezzi, M. J.; Dutton, J. C.

1992-01-01

A particle image velocimetry (PIV) system has been developed for use in high-speed separated air flows. The image acquisition system uses two 550 mJ/pulse Nd:YAG lasers and is fully controlled by a host Macintosh computer. The interrogation system is also Macintosh-based and performs interrogations at approximately 2.3 sec/spot and 4.0 sec/spot when using the Young's fringe and autocorrelation methods, respectively. The system has been proven in preliminary experiments using known-displacement simulated PIV photographs and a simple axisymmetric jet flow. Further results have been obtained in a transonic wind tunnel operating at Mach 0.4 to 0.5 (135 m/s to 170 m/s). PIV experiments were done with an empty test section to provide uniform flow data for comparison with pressure and LDV data, then with a two-dimensional base model, revealing features of the von Karman vortex street wake and underlying small scale turbulence.

[Remote access to a web-based image distribution system].

PubMed

Bergh, B; Schlaefke, A; Frankenbach, R; Vogl, T J

2004-06-01

To assess different network and security technologies for remote access to a web-based image distribution system of a hospital intranet. Following preparatory testing, the time-to-display (TTD) was measured for three image types (CR, CT, MR). The evaluation included two remote access technologies consisting of direct ISDN-Dial-Up or VPN connection (Virtual Private Network), with three different connection speeds of 64, 128 (ISDN) and 768 Kbit/s (ADSL-Asymmetric Digital Subscriber Line), as well as with lossless and lossy compression. Depending on the image type, the TTD with lossless compression for 64 Kbit/s varied from 1 : 00 to 2 : 40 minutes, for 128 Kbit/s from 0 : 35 to 1 : 15 minutes and for ADSL from 0 : 15 to 0 : 45 minutes. The ISDN-Dial-Up connection was superior to VPN technology at 64 Kbit/s but did not allow higher connection speeds. Lossy compression reduced the TTD by half for all measurements. VPN technology is preferable to direct Dial-Up connections since it offers higher connection speeds and advantages in usage and security. For occasional usage, 128 Kbit/s (ISDN) can be considered sufficient, especially in conjunction with lossy compression. ADSL should be chosen when a more frequent usage is anticipated, whereby lossy compression may be omitted. Due to higher bandwidths and improved usability, the web-based approach appears superior to conventional teleradiology systems.

TH-A-207B-02: QIBA Ultrasound Elasticity Imaging System Biomarker Qualification and User Testing of Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garra, B.

Imaging of tissue elastic properties is a relatively new and powerful approach to one of the oldest and most important diagnostic tools. Imaging of shear wave speed with ultrasound is has been added to most high-end ultrasound systems. Understanding this exciting imaging mode aiding its most effective use in medicine can be a rewarding effort for medical physicists and other medical imaging and treatment professionals. Assuring consistent, quantitative measurements across the many ultrasound systems in a typical imaging department will constitute a major step toward realizing the great potential of this technique and other quantitative imaging. This session will targetmore » these two goals with two presentations. A. Basics and Current Implementations of Ultrasound Imaging of Shear Wave Speed and Elasticity - Shigao Chen, Ph.D. Learning objectives-To understand: Introduction: Importance of tissue elasticity measurement Strain vs. shear wave elastography (SWE), beneficial features of SWE The link between shear wave speed and material properties, influence of viscosity Generation of shear waves External vibration (Fibroscan) ultrasound radiation force Point push Supersonic push (Aixplorer) Comb push (GE Logiq E9) Detection of shear waves Motion detection from pulse-echo ultrasound Importance of frame rate for shear wave imaging Plane wave imaging detection How to achieve high effective frame rate using line-by-line scanners Shear wave speed calculation Time to peak Random sample consensus (RANSAC) Cross correlation Sources of bias and variation in SWE Tissue viscosity Transducer compression or internal pressure of organ Reflection of shear waves at boundaries B. Elasticity Imaging System Biomarker Qualification and User Testing of Systems – Brian Garra, M.D. Learning objectives-To understand: Goals Review the need for quantitative medical imaging Provide examples of quantitative imaging biomarkers Acquaint the participant with the purpose of the RSNA Quantitative Imaging Biomarker Alliance and the need for such an organization Review the QIBA process for creating a quantitative biomarker Summarize steps needed to verify adherence of site, operators, and imaging systems to a QIBA profile Underlying Premise and Assumptions Objective, quantifiable results are needed to enhance the value of diagnostic imaging in clinical practice Reasons for quantification Evidence based medicine requires objective, not subjective observer data Computerized decision support tools (eg CAD) generally require quantitative input. Quantitative, reproducible measures are more easily used to develop personalized molecular medical diagnostic and treatment systems What is quantitative imaging? Definition from Imaging Metrology Workshop The Quantitative Imaging Biomarker Alliance Formation 2008 Mission Structure Example Imaging Biomarkers Being Explored Biomarker Selection Groundwork Draft Protocol for imaging and data evaluation QIBA Profile Drafting Equipment and Site Validation Technical Clinical Site and Equipment QA and Compliance Checking Ultrasound Elasticity Estimation Biomarker US Elasticity Estimation Background Current Status and Problems Biomarker Selection-process and outcome US SWS for Liver Fibrosis Biomarker Work Groundwork Literature search and analysis results Phase I phantom testing-Elastic phantoms Phase II phantom testing-Viscoelastic phantoms Digital Simulated Data Protocol and Profile Drafting Protocol: based on UPICT and existing literature and standards bodies protocols Profile-Current claims, Manufacturer specific appendices What comes after the profile Profile Validation Technical validation Clinical validation QA and Compliance Possible approaches Site Operator testing Site protocol re-evaluation Imaging system Manufacturer testing and attestation User acceptance testing and periodic QA Phantom Tests Digital Phantom Based Testing Standard QA Testing Remediation Schemes Profile Evolution Towards additional applications Towards higher accuracy and precision Supported in part by NIH contract HHSN268201300071C from NIBIB. Collaboration with GE Global Research, no personal support.; S. Chen, Some technologies described in this presentation have been licensed. Mayo Clinic and Dr. Chen have financial interests these technologies.« less

High speed movies of turbulence in Alcator C-Mod

DOE Office of Scientific and Technical Information (OSTI.GOV)

Terry, J.L.; Zweben, S.J.; Bose, B.

2004-10-01

A high speed (250 kHz), 300 frame charge coupled device camera has been used to image turbulence in the Alcator C-Mod Tokamak. The camera system is described and some of its important characteristics are measured, including time response and uniformity over the field-of-view. The diagnostic has been used in two applications. One uses gas-puff imaging to illuminate the turbulence in the edge/scrape-off-layer region, where D{sub 2} gas puffs localize the emission in a plane perpendicular to the magnetic field when viewed by the camera system. The dynamics of the underlying turbulence around and outside the separatrix are detected in thismore » manner. In a second diagnostic application, the light from an injected, ablating, high speed Li pellet is observed radially from the outer midplane, and fast poloidal motion of toroidal striations are seen in the Li{sup +} light well inside the separatrix.« less

Indirect Charged Particle Detection: Concepts and a Classroom Demonstration

NASA Astrophysics Data System (ADS)

Childs, Nicholas B.; Horányi, Mihály; Collette, Andrew

2013-11-01

We describe the principles of macroscopic charged particle detection in the laboratory and their connections to concepts taught in the physics classroom. Electrostatic dust accelerator systems, capable of launching charged dust grains at hypervelocities (1-100 km/s), are a critical tool for space exploration. Dust grains in space typically have large speeds relative to the probes or satellites that encounter them. Development and testing of instruments that look for dust in space therefore depends critically on the availability of fast, well-characterized dust grains in the laboratory. One challenge for the experimentalist is to precisely measure the speed and mass of laboratory dust particles without disturbing them. Detection systems currently in use exploit the well-known effect of image charge to register the passage of dust grains without changing their speed or mass. We describe the principles of image charge detection and provide a simple classroom demonstration of the technique using soup cans and pith balls.

Single-chip microcomputer for image processing in the photonic measuring system

NASA Astrophysics Data System (ADS)

Smoleva, Olga S.; Ljul, Natalia Y.

2002-04-01

The non-contact measuring system has been designed for rail- track parameters control on the Moscow Metro. It detects some significant parameters: rail-track width, rail-track height, gage, rail-slums, crosslevel, pickets, and car speed. The system consists of three subsystems: non-contact system of rail-track width, height, and gage inspection, non-contact system of rail-slums inspection and subsystem for crosslevel, speed, and pickets detection. Data from subsystems is transferred to pre-processing unit. In order to process data received from subsystems, the single-chip signal processor ADSP-2185 must be used due to providing required processing speed. After data will be processed, it is send to PC, which processes it and outputs it in the readable form.

High speed all optical shear wave imaging optical coherence elastography (Conference Presentation)

NASA Astrophysics Data System (ADS)

Song, Shaozhen; Hsieh, Bao-Yu; Wei, Wei; Shen, Tueng; O'Donnell, Matthew; Wang, Ruikang K.

2016-03-01

Optical Coherence Elastography (OCE) is a non-invasive testing modality that maps the mechanical property of soft tissues with high sensitivity and spatial resolution using phase-sensitive optical coherence tomography (PhS-OCT). Shear wave OCE (SW-OCE) is a leading technique that relies on the speed of propagating shear waves to provide a quantitative elastography. Previous shear wave imaging OCT techniques are based on repeated M-B scans, which have several drawbacks such as long acquisition time and repeated wave stimulations. Recent developments of Fourier domain mode-locked high-speed swept-source OCT system has enabled enough speed to perform KHz B-scan rate OCT imaging. Here we propose ultra-high speed, single shot shear wave imaging to capture single-shot transient shear wave propagation to perform SW-OCE. The frame rate of shear wave imaging is 16 kHz, at A-line rate of ~1.62 MHz, which allows the detection of high-frequency shear wave of up to 8 kHz. The shear wave is generated photothermal-acoustically, by ultra-violet pulsed laser, which requires no contact to OCE subjects, while launching high frequency shear waves that carries rich localized elasticity information. The image acquisition and processing can be performed at video-rate, which enables real-time 3D elastography. SW-OCE measurements are demonstrated on tissue-mimicking phantoms and porcine ocular tissue. This approach opens up the feasibility to perform real-time 3D SW-OCE in clinical applications, to obtain high-resolution localized quantitative measurement of tissue biomechanical property.

Image processing for safety assessment in civil engineering.

PubMed

Ferrer, Belen; Pomares, Juan C; Irles, Ramon; Espinosa, Julian; Mas, David

2013-06-20

Behavior analysis of construction safety systems is of fundamental importance to avoid accidental injuries. Traditionally, measurements of dynamic actions in civil engineering have been done through accelerometers, but high-speed cameras and image processing techniques can play an important role in this area. Here, we propose using morphological image filtering and Hough transform on high-speed video sequence as tools for dynamic measurements on that field. The presented method is applied to obtain the trajectory and acceleration of a cylindrical ballast falling from a building and trapped by a thread net. Results show that safety recommendations given in construction codes can be potentially dangerous for workers.

MSTB 2 x 6-Inch Low Speed Tunnel Turbulence Generator Grid/Honeycomb PIV Measurements and Analysis

NASA Technical Reports Server (NTRS)

Blackshire, James L.

1997-01-01

An assessment of the turbulence levels present in the Measurement Science and Technology (MSTB) branch's 2 x 6-inch low speed wind tunnel was made using Particle Image Velocimetry (PIV), and a turbulence generator consisting of a grid/honeycomb structure. Approximately 3000 digital PIV images were captured and analyzed covering an approximate 2 x 6-inch area along the centerline of the tunnel just beyond the turbulence generator system. Custom software for analysis and acquisition was developed for semi-automated digital PIV image acquisition and analysis. Comparisons between previously obtained LTA and LV turbulence measurements taken in the tunnel are presented.

Laryngeal High-Speed Videoendoscopy: Rationale and Recommendation for Accurate and Consistent Terminology

PubMed Central

Deliyski, Dimitar D.; Hillman, Robert E.

2015-01-01

Purpose The authors discuss the rationale behind the term laryngeal high-speed videoendoscopy to describe the application of high-speed endoscopic imaging techniques to the visualization of vocal fold vibration. Method Commentary on the advantages of using accurate and consistent terminology in the field of voice research is provided. Specific justification is described for each component of the term high-speed videoendoscopy, which is compared and contrasted with alternative terminologies in the literature. Results In addition to the ubiquitous high-speed descriptor, the term endoscopy is necessary to specify the appropriate imaging technology and distinguish among modalities such as ultrasound, magnetic resonance imaging, and nonendoscopic optical imaging. Furthermore, the term video critically indicates the electronic recording of a sequence of optical still images representing scenes in motion, in contrast to strobed images using high-speed photography and non-optical high-speed magnetic resonance imaging. High-speed videoendoscopy thus concisely describes the technology and can be appended by the desired anatomical nomenclature such as laryngeal. Conclusions Laryngeal high-speed videoendoscopy strikes a balance between conciseness and specificity when referring to the typical high-speed imaging method performed on human participants. Guidance for the creation of future terminology provides clarity and context for current and future experiments and the dissemination of results among researchers. PMID:26375398

Efficient space-time sampling with pixel-wise coded exposure for high-speed imaging.

PubMed

Liu, Dengyu; Gu, Jinwei; Hitomi, Yasunobu; Gupta, Mohit; Mitsunaga, Tomoo; Nayar, Shree K

2014-02-01

Cameras face a fundamental trade-off between spatial and temporal resolution. Digital still cameras can capture images with high spatial resolution, but most high-speed video cameras have relatively low spatial resolution. It is hard to overcome this trade-off without incurring a significant increase in hardware costs. In this paper, we propose techniques for sampling, representing, and reconstructing the space-time volume to overcome this trade-off. Our approach has two important distinctions compared to previous works: 1) We achieve sparse representation of videos by learning an overcomplete dictionary on video patches, and 2) we adhere to practical hardware constraints on sampling schemes imposed by architectures of current image sensors, which means that our sampling function can be implemented on CMOS image sensors with modified control units in the future. We evaluate components of our approach, sampling function and sparse representation, by comparing them to several existing approaches. We also implement a prototype imaging system with pixel-wise coded exposure control using a liquid crystal on silicon device. System characteristics such as field of view and modulation transfer function are evaluated for our imaging system. Both simulations and experiments on a wide range of scenes show that our method can effectively reconstruct a video from a single coded image while maintaining high spatial resolution.

Variety and evolution of American endoscopic image management and recording systems.

PubMed

Korman, L Y

1996-03-01

The rapid evolution of computing technology has and will continue to alter the practice of gastroenterology and gastrointestinal endoscopy. Development of communication standards for text, images, and security systems will be necessary for medicine to take advantage of high-speed computing and communications. Professional societies can have an important role in guiding the development process.

Solid-state NMR imaging system

DOEpatents

Gopalsami, Nachappa; Dieckman, Stephen L.; Ellingson, William A.

1992-01-01

An apparatus for use with a solid-state NMR spectrometer includes a special imaging probe with linear, high-field strength gradient fields and high-power broadband RF coils using a back projection method for data acquisition and image reconstruction, and a real-time pulse programmer adaptable for use by a conventional computer for complex high speed pulse sequences.

High-speed polarization sensitive optical frequency domain imaging with frequency multiplexing

PubMed Central

Yun, S.H.; Vakoc, B.J.; Shishkov, M.; Desjardins, A.E.; Park, B.H.; de Boer, J.F.; Tearney, G.J.; Bouma, B.E.

2009-01-01

Polarization sensitive optical coherence tomography (PS-OCT) provides a cross-sectional image of birefringence in biological samples that is complementary in many applications to the standard reflectance-based image. Recent ex vivo studies have demonstrated that birefringence mapping enables the characterization of collagen and smooth muscle concentration and distribution in vascular tissues. Instruments capable of applying these measurements percutaneously in vivo may provide new insights into coronary atherosclerosis and acute myocardial infarction. We have developed a polarization sensitive optical frequency domain imaging (PS-OFDI) system that enables high-speed intravascular birefringence imaging through a fiber-optic catheter. The novel design of this system utilizes frequency multiplexing to simultaneously measure reflectance of two incident polarization states, overcoming concerns regarding temporal variations of the catheter fiber birefringence and spatial variations in the birefringence of the sample. We demonstrate circular cross-sectional birefringence imaging of a human coronary artery ex vivo through a flexible fiber-optic catheter with an A-line rate of 62 kHz and a ranging depth of 6.2 mm. PMID:18542183

PACS in Töölö hospital.

PubMed

Kinnunen, J; Pohjonen, H

2001-07-01

A 3-year PACS project was started in 1997 and completed in 1999 with filmless radiology and surgery. An efficient network for transferring images provides the infrastructure for integration of different distributed imaging systems and enables efficient handling of all patient-related information on one display station. Because of the need for high-speed communications and the massive amount of image data transferred in radiology, ATM (25, 155 Mbit/s) was chosen to be the main technology used. Both hardware and software redundancy of the system have been carefully planned. The size of the Dicom image library utilizing MO discs is currently 1.2 TB with 300 GB RAID capacity. For the increasing amount of teleradiologic consultations, a special Dicom gateway is planned. It allows a centralized and resilient handling and routing of received images around the hospital. Hospital-wide PACS has already improved the speed and quality of patient care by providing instant access to diagnostic information at multiple locations simultaneously. The benefits of PACS are considered from the viewpoint of the entire hospital: PACS offers a method for efficiently transporting patient-related images and reports to the referring physicians.

Online measurement for geometrical parameters of wheel set based on structure light and CUDA parallel processing

NASA Astrophysics Data System (ADS)

Wu, Kaihua; Shao, Zhencheng; Chen, Nian; Wang, Wenjie

2018-01-01

The wearing degree of the wheel set tread is one of the main factors that influence the safety and stability of running train. Geometrical parameters mainly include flange thickness and flange height. Line structure laser light was projected on the wheel tread surface. The geometrical parameters can be deduced from the profile image. An online image acquisition system was designed based on asynchronous reset of CCD and CUDA parallel processing unit. The image acquisition was fulfilled by hardware interrupt mode. A high efficiency parallel segmentation algorithm based on CUDA was proposed. The algorithm firstly divides the image into smaller squares, and extracts the squares of the target by fusion of k_means and STING clustering image segmentation algorithm. Segmentation time is less than 0.97ms. A considerable acceleration ratio compared with the CPU serial calculation was obtained, which greatly improved the real-time image processing capacity. When wheel set was running in a limited speed, the system placed alone railway line can measure the geometrical parameters automatically. The maximum measuring speed is 120km/h.

Using level set based inversion of arrival times to recover shear wave speed in transient elastography and supersonic imaging

NASA Astrophysics Data System (ADS)

McLaughlin, Joyce; Renzi, Daniel

2006-04-01

Transient elastography and supersonic imaging are promising new techniques for characterizing the elasticity of soft tissues. Using this method, an 'ultrafast imaging' system (up to 10 000 frames s-1) follows in real time the propagation of a low-frequency shear wave. The displacement of the propagating shear wave is measured as a function of time and space. Here we develop a fast level set based algorithm for finding the shear wave speed from the interior positions of the propagating front. We compare the performance of level curve methods developed here and our previously developed (McLaughlin J and Renzi D 2006 Shear wave speed recovery in transient elastography and supersonic imaging using propagating fronts Inverse Problems 22 681-706) distance methods. We give reconstruction examples from synthetic data and from data obtained from a phantom experiment accomplished by Mathias Fink's group (the Laboratoire Ondes et Acoustique, ESPCI, Université Paris VII).

Using a high-speed movie camera to evaluate slice dropping in clinical image interpretation with stack mode viewers.

PubMed

Yakami, Masahiro; Yamamoto, Akira; Yanagisawa, Morio; Sekiguchi, Hiroyuki; Kubo, Takeshi; Togashi, Kaori

2013-06-01

The purpose of this study is to verify objectively the rate of slice omission during paging on picture archiving and communication system (PACS) viewers by recording the images shown on the computer displays of these viewers with a high-speed movie camera. This study was approved by the institutional review board. A sequential number from 1 to 250 was superimposed on each slice of a series of clinical Digital Imaging and Communication in Medicine (DICOM) data. The slices were displayed using several DICOM viewers, including in-house developed freeware and clinical PACS viewers. The freeware viewer and one of the clinical PACS viewers included functions to prevent slice dropping. The series was displayed in stack mode and paged in both automatic and manual paging modes. The display was recorded with a high-speed movie camera and played back at a slow speed to check whether slices were dropped. The paging speeds were also measured. With a paging speed faster than half the refresh rate of the display, some viewers dropped up to 52.4 % of the slices, while other well-designed viewers did not, if used with the correct settings. Slice dropping during paging was objectively confirmed using a high-speed movie camera. To prevent slice dropping, the viewer must be specially designed for the purpose and must be used with the correct settings, or the paging speed must be slower than half of the display refresh rate.

Markov Processes in Image Processing

NASA Astrophysics Data System (ADS)

Petrov, E. P.; Kharina, N. L.

2018-05-01

Digital images are used as an information carrier in different sciences and technologies. The aspiration to increase the number of bits in the image pixels for the purpose of obtaining more information is observed. In the paper, some methods of compression and contour detection on the basis of two-dimensional Markov chain are offered. Increasing the number of bits on the image pixels will allow one to allocate fine object details more precisely, but it significantly complicates image processing. The methods of image processing do not concede by the efficiency to well-known analogues, but surpass them in processing speed. An image is separated into binary images, and processing is carried out in parallel with each without an increase in speed, when increasing the number of bits on the image pixels. One more advantage of methods is the low consumption of energy resources. Only logical procedures are used and there are no computing operations. The methods can be useful in processing images of any class and assignment in processing systems with a limited time and energy resources.

Quantum Color Image Encryption Algorithm Based on A Hyper-Chaotic System and Quantum Fourier Transform

NASA Astrophysics Data System (ADS)

Tan, Ru-Chao; Lei, Tong; Zhao, Qing-Min; Gong, Li-Hua; Zhou, Zhi-Hong

2016-12-01

To improve the slow processing speed of the classical image encryption algorithms and enhance the security of the private color images, a new quantum color image encryption algorithm based on a hyper-chaotic system is proposed, in which the sequences generated by the Chen's hyper-chaotic system are scrambled and diffused with three components of the original color image. Sequentially, the quantum Fourier transform is exploited to fulfill the encryption. Numerical simulations show that the presented quantum color image encryption algorithm possesses large key space to resist illegal attacks, sensitive dependence on initial keys, uniform distribution of gray values for the encrypted image and weak correlation between two adjacent pixels in the cipher-image.

Ultrasound tomography imaging with waveform sound speed: parenchymal changes in women undergoing tamoxifen therapy

NASA Astrophysics Data System (ADS)

Sak, Mark; Duric, Neb; Littrup, Peter; Sherman, Mark; Gierach, Gretchen

2017-03-01

Ultrasound tomography (UST) is an emerging modality that can offer quantitative measurements of breast density. Recent breakthroughs in UST image reconstruction involve the use of a waveform reconstruction as opposed to a raybased reconstruction. The sound speed (SS) images that are created using the waveform reconstruction have a much higher image quality. These waveform images offer improved resolution and contrasts between regions of dense and fatty tissues. As part of a study that was designed to assess breast density changes using UST sound speed imaging among women undergoing tamoxifen therapy, UST waveform sound speed images were then reconstructed for a subset of participants. These initial results show that changes to the parenchymal tissue can more clearly be visualized when using the waveform sound speed images. Additional quantitative testing of the waveform images was also started to test the hypothesis that waveform sound speed images are a more robust measure of breast density than ray-based reconstructions. Further analysis is still needed to better understand how tamoxifen affects breast tissue.

Application of a digital high-speed camera and image processing system for investigations of short-term hypersonic fluids

NASA Astrophysics Data System (ADS)

Renken, Hartmut; Oelze, Holger W.; Rath, Hans J.

1998-04-01

The design and application of a digital high sped image data capturing system with a following image processing system applied to the Bremer Hochschul Hyperschallkanal BHHK is the content of this presentation. It is also the result of the cooperation between the departments aerodynamic and image processing at the ZARM-institute at the Drop Tower of Brennen. Similar systems are used by the combustion working group at ZARM and other external project partners. The BHHK, camera- and image storage system as well as the personal computer based image processing software are described next. Some examples of images taken at the BHHK are shown to illustrate the application. The new and very user-friendly Windows 32-bit system is capable to capture all camera data with a maximum pixel clock of 43 MHz and to process complete sequences of images in one step by using only one comfortable program.

A Guide to Structured Illumination TIRF Microscopy at High Speed with Multiple Colors

PubMed Central

Young, Laurence J.; Ströhl, Florian; Kaminski, Clemens F.

2016-01-01

Optical super-resolution imaging with structured illumination microscopy (SIM) is a key technology for the visualization of processes at the molecular level in the chemical and biomedical sciences. Although commercial SIM systems are available, systems that are custom designed in the laboratory can outperform commercial systems, the latter typically designed for ease of use and general purpose applications, both in terms of imaging fidelity and speed. This article presents an in-depth guide to building a SIM system that uses total internal reflection (TIR) illumination and is capable of imaging at up to 10 Hz in three colors at a resolution reaching 100 nm. Due to the combination of SIM and TIRF, the system provides better image contrast than rival technologies. To achieve these specifications, several optical elements are used to enable automated control over the polarization state and spatial structure of the illumination light for all available excitation wavelengths. Full details on hardware implementation and control are given to achieve synchronization between excitation light pattern generation, wavelength, polarization state, and camera control with an emphasis on achieving maximum acquisition frame rate. A step-by-step protocol for system alignment and calibration is presented and the achievable resolution improvement is validated on ideal test samples. The capability for video-rate super-resolution imaging is demonstrated with living cells. PMID:27285848

DURIP: A Confocal Imaging System for Ultra-Fast Three-Dimensional Transport Studies in Thermal Management Applications

DTIC Science & Technology

2011-12-01

Transport Phenomena and Thermal Management Applications,” Proceedings of the XXVIII UIT Heat Transfer Conference, Brescia, Italy, June 21-23, 2010...measurements in microscale systems. The integrated confocal microscope system is a critical component to obtain understanding of fluid- heat ...objective of this work was to develop a high speed three-dimensional (3D) confocal imaging system to study coupled fluidic and heat transport

High-accuracy and robust face recognition system based on optical parallel correlator using a temporal image sequence

NASA Astrophysics Data System (ADS)

Watanabe, Eriko; Ishikawa, Mami; Ohta, Maiko; Kodate, Kashiko

2005-09-01

Face recognition is used in a wide range of security systems, such as monitoring credit card use, searching for individuals with street cameras via Internet and maintaining immigration control. There are still many technical subjects under study. For instance, the number of images that can be stored is limited under the current system, and the rate of recognition must be improved to account for photo shots taken at different angles under various conditions. We implemented a fully automatic Fast Face Recognition Optical Correlator (FARCO) system by using a 1000 frame/s optical parallel correlator designed and assembled by us. Operational speed for the 1: N (i.e. matching a pair of images among N, where N refers to the number of images in the database) identification experiment (4000 face images) amounts to less than 1.5 seconds, including the pre/post processing. From trial 1: N identification experiments using FARCO, we acquired low error rates of 2.6% False Reject Rate and 1.3% False Accept Rate. By making the most of the high-speed data-processing capability of this system, much more robustness can be achieved for various recognition conditions when large-category data are registered for a single person. We propose a face recognition algorithm for the FARCO while employing a temporal image sequence of moving images. Applying this algorithm to a natural posture, a two times higher recognition rate scored compared with our conventional system. The system has high potential for future use in a variety of purposes such as search for criminal suspects by use of street and airport video cameras, registration of babies at hospitals or handling of an immeasurable number of images in a database.

High-performance image processing on the desktop

NASA Astrophysics Data System (ADS)

Jordan, Stephen D.

1996-04-01

The suitability of computers to the task of medical image visualization for the purposes of primary diagnosis and treatment planning depends on three factors: speed, image quality, and price. To be widely accepted the technology must increase the efficiency of the diagnostic and planning processes. This requires processing and displaying medical images of various modalities in real-time, with accuracy and clarity, on an affordable system. Our approach to meeting this challenge began with market research to understand customer image processing needs. These needs were translated into system-level requirements, which in turn were used to determine which image processing functions should be implemented in hardware. The result is a computer architecture for 2D image processing that is both high-speed and cost-effective. The architectural solution is based on the high-performance PA-RISC workstation with an HCRX graphics accelerator. The image processing enhancements are incorporated into the image visualization accelerator (IVX) which attaches to the HCRX graphics subsystem. The IVX includes a custom VLSI chip which has a programmable convolver, a window/level mapper, and an interpolator supporting nearest-neighbor, bi-linear, and bi-cubic modes. This combination of features can be used to enable simultaneous convolution, pan, zoom, rotate, and window/level control into 1 k by 1 k by 16-bit medical images at 40 frames/second.

X-ray cargo container inspection system with few-view projection imaging

NASA Astrophysics Data System (ADS)

Duan, Xinhui; Cheng, Jianping; Zhang, Li; Xing, Yuxiang; Chen, Zhiqiang; Zhao, Ziran

2009-01-01

An X-ray cargo inspection system with few-view projection imaging is developed for detecting contraband in air containers. This paper describes this developing inspection system, including its configuration and the process of inspection using three imaging modalities: digital radiography (DR), few view imaging and computed tomography (CT). The few-view imaging can provide 3D images with much faster scanning speed than CT and do great help to quickly locate suspicious cargo in a container. An algorithm to reconstruct tomographic images from severely sparse projection data of few-view imaging is discussed. A cooperative work manner of the three modalities is presented to make the inspection more convenient and effective. Numerous experiments of performance tests and modality comparison are performed on our system for inspecting air containers. Results demonstrate the effectiveness of our methods and implementation of few-view imaging in practical inspection systems.

Multiscale Imaging of the Mouse Cortex Using Two-Photon Microscopy and Wide-Field Illumination

NASA Astrophysics Data System (ADS)

Bumstead, Jonathan R.

The mouse brain can be studied over vast spatial scales ranging from microscopic imaging of single neurons to macroscopic measurements of hemodynamics acquired over the majority of the mouse cortex. However, most neuroimaging modalities are limited by a fundamental trade-off between the spatial resolution and the field-of-view (FOV) over which the brain can be imaged, making it difficult to fully understand the functional and structural architecture of the healthy mouse brain and its disruption in disease. My dissertation has focused on developing multiscale optical systems capable of imaging the mouse brain at both microscopic and mesoscopic spatial scales, specifically addressing the difference in spatial scales imaged with two-photon microscopy (TPM) and optical intrinsic signal imaging (OISI). Central to this work has been the formulation of a principled design strategy for extending the FOV of the two-photon microscope. Using this design approach, we constructed a TPM system with subcellular resolution and a FOV area 100 times greater than a conventional two-photon microscope. To image the ellipsoidal shape of the mouse cortex, we also developed the microscope to image arbitrary surfaces within a single frame using an electrically tunable lens. Finally, to address the speed limitations of the TPM systems developed during my dissertation, I also conducted research in large-scale neural phenomena occurring in the mouse brain imaged with high-speed OISI. The work conducted during my dissertation addresses some of the fundamental principles in designing and applying optical systems for multiscale imaging of the mouse brain.

A Control System and Streaming DAQ Platform with Image-Based Trigger for X-ray Imaging

NASA Astrophysics Data System (ADS)

Stevanovic, Uros; Caselle, Michele; Cecilia, Angelica; Chilingaryan, Suren; Farago, Tomas; Gasilov, Sergey; Herth, Armin; Kopmann, Andreas; Vogelgesang, Matthias; Balzer, Matthias; Baumbach, Tilo; Weber, Marc

2015-06-01

High-speed X-ray imaging applications play a crucial role for non-destructive investigations of the dynamics in material science and biology. On-line data analysis is necessary for quality assurance and data-driven feedback, leading to a more efficient use of a beam time and increased data quality. In this article we present a smart camera platform with embedded Field Programmable Gate Array (FPGA) processing that is able to stream and process data continuously in real-time. The setup consists of a Complementary Metal-Oxide-Semiconductor (CMOS) sensor, an FPGA readout card, and a readout computer. It is seamlessly integrated in a new custom experiment control system called Concert that provides a more efficient way of operating a beamline by integrating device control, experiment process control, and data analysis. The potential of the embedded processing is demonstrated by implementing an image-based trigger. It records the temporal evolution of physical events with increased speed while maintaining the full field of view. The complete data acquisition system, with Concert and the smart camera platform was successfully integrated and used for fast X-ray imaging experiments at KIT's synchrotron radiation facility ANKA.

Remote gaze tracking system on a large display.

PubMed

Lee, Hyeon Chang; Lee, Won Oh; Cho, Chul Woo; Gwon, Su Yeong; Park, Kang Ryoung; Lee, Heekyung; Cha, Jihun

2013-10-07

We propose a new remote gaze tracking system as an intelligent TV interface. Our research is novel in the following three ways: first, because a user can sit at various positions in front of a large display, the capture volume of the gaze tracking system should be greater, so the proposed system includes two cameras which can be moved simultaneously by panning and tilting mechanisms, a wide view camera (WVC) for detecting eye position and an auto-focusing narrow view camera (NVC) for capturing enlarged eye images. Second, in order to remove the complicated calibration between the WVC and NVC and to enhance the capture speed of the NVC, these two cameras are combined in a parallel structure. Third, the auto-focusing of the NVC is achieved on the basis of both the user's facial width in the WVC image and a focus score calculated on the eye image of the NVC. Experimental results showed that the proposed system can be operated with a gaze tracking accuracy of ±0.737°~±0.775° and a speed of 5~10 frames/s.

Remote Gaze Tracking System on a Large Display

PubMed Central

Lee, Hyeon Chang; Lee, Won Oh; Cho, Chul Woo; Gwon, Su Yeong; Park, Kang Ryoung; Lee, Heekyung; Cha, Jihun

2013-01-01

We propose a new remote gaze tracking system as an intelligent TV interface. Our research is novel in the following three ways: first, because a user can sit at various positions in front of a large display, the capture volume of the gaze tracking system should be greater, so the proposed system includes two cameras which can be moved simultaneously by panning and tilting mechanisms, a wide view camera (WVC) for detecting eye position and an auto-focusing narrow view camera (NVC) for capturing enlarged eye images. Second, in order to remove the complicated calibration between the WVC and NVC and to enhance the capture speed of the NVC, these two cameras are combined in a parallel structure. Third, the auto-focusing of the NVC is achieved on the basis of both the user's facial width in the WVC image and a focus score calculated on the eye image of the NVC. Experimental results showed that the proposed system can be operated with a gaze tracking accuracy of ±0.737°∼±0.775° and a speed of 5∼10 frames/s. PMID:24105351

Full-frame, high-speed 3D shape and deformation measurements using stereo-digital image correlation and a single color high-speed camera

NASA Astrophysics Data System (ADS)

Yu, Liping; Pan, Bing

2017-08-01

Full-frame, high-speed 3D shape and deformation measurement using stereo-digital image correlation (stereo-DIC) technique and a single high-speed color camera is proposed. With the aid of a skillfully designed pseudo stereo-imaging apparatus, color images of a test object surface, composed of blue and red channel images from two different optical paths, are recorded by a high-speed color CMOS camera. The recorded color images can be separated into red and blue channel sub-images using a simple but effective color crosstalk correction method. These separated blue and red channel sub-images are processed by regular stereo-DIC method to retrieve full-field 3D shape and deformation on the test object surface. Compared with existing two-camera high-speed stereo-DIC or four-mirror-adapter-assisted singe-camera high-speed stereo-DIC, the proposed single-camera high-speed stereo-DIC technique offers prominent advantages of full-frame measurements using a single high-speed camera but without sacrificing its spatial resolution. Two real experiments, including shape measurement of a curved surface and vibration measurement of a Chinese double-side drum, demonstrated the effectiveness and accuracy of the proposed technique.

High-Speed Edge-Detecting Line Scan Smart Camera

NASA Technical Reports Server (NTRS)

Prokop, Norman F.

2012-01-01

A high-speed edge-detecting line scan smart camera was developed. The camera is designed to operate as a component in a NASA Glenn Research Center developed inlet shock detection system. The inlet shock is detected by projecting a laser sheet through the airflow. The shock within the airflow is the densest part and refracts the laser sheet the most in its vicinity, leaving a dark spot or shadowgraph. These spots show up as a dip or negative peak within the pixel intensity profile of an image of the projected laser sheet. The smart camera acquires and processes in real-time the linear image containing the shock shadowgraph and outputting the shock location. Previously a high-speed camera and personal computer would perform the image capture and processing to determine the shock location. This innovation consists of a linear image sensor, analog signal processing circuit, and a digital circuit that provides a numerical digital output of the shock or negative edge location. The smart camera is capable of capturing and processing linear images at over 1,000 frames per second. The edges are identified as numeric pixel values within the linear array of pixels, and the edge location information can be sent out from the circuit in a variety of ways, such as by using a microcontroller and onboard or external digital interface to include serial data such as RS-232/485, USB, Ethernet, or CAN BUS; parallel digital data; or an analog signal. The smart camera system can be integrated into a small package with a relatively small number of parts, reducing size and increasing reliability over the previous imaging system..

Method of recognizing the high-speed railway noise barriers based on the distance image

NASA Astrophysics Data System (ADS)

Ma, Le; Shao, Shuangyun; Feng, Qibo; Liu, Bingqian; Kim, Chol Ryong

2016-10-01

The damage or lack of the noise barriers is one of the important hidden troubles endangering the safety of high-speed railway. In order to obtain the vibration information of the noise barriers, the online detection systems based on laser vision were proposed. The systems capture images of the laser stripe on the noise barriers and export data files containing distance information between the detection systems on the train and the noise barriers. The vibration status or damage of the noise barriers can be estimated depending on the distance information. In this paper, we focused on the method of separating the area of noise barrier from the background automatically. The test results showed that the proposed method is in good efficiency and accuracy.

Preliminary Electrical Designs for CTEX and AFIT Satellite Ground Station

DTIC Science & Technology

2010-03-01

with additional IO High-Speed Piezo Tip/Tilt Platforms S-340 Platform Recommended Models Mirror Aluminum Aluminum S-340.Ax Invar Zerodur glass S-340...developed by RC Optics that uses internal steer- able mirrors that point the optics without slewing the entire instrument. The imaging system is composed of...Determination System Telescope Assembly CTEx Imaging System DCCU Camera Motor/Encoder Assemby FSM & Control Electronics Dwell Mirror w/ 2

High-speed quantitative phase imaging using time-stretch spectral shearing contrast (Conference Presentation)

NASA Astrophysics Data System (ADS)

Bosworth, Bryan; Foster, Mark A.

2017-02-01

Photonic time-stretch microscopy (TSM) provides an ideal platform for high-throughput imaging flow cytometry, affording extremely high shutter speeds and frame rates with high sensitivity. In order to resolve weakly scattering cells in biofluid and solve the issue of signal-to-noise in cell labeling specificity of biomarkers in imaging flow cytometry, several quantitative phase (QP) techniques have recently been adapted to TSM. However, these techniques have relied primarily on sensitive free-space optical configurations to generate full electric field measurements. The present work draws from the field of ultrashort pulse characterization to leverage the coherence of the ultrashort optical pulses integral to all TSM systems in order to do self-referenced single-shot quantitative phase imaging in a TSM system. Self-referencing is achieved via spectral shearing interferometry in an exceptionally stable and straightforward Sagnac loop incorporating an electro-optic phase modulator and polarization-maintaining fiber that produce sheared and unsheared copies of the pulse train with an inter-pulse delay determined by polarization mode dispersion. The spectral interferogram then yields a squared amplitude and a phase derivative image that can be integrated for conventional phase. We apply this spectral shearing contrast microscope to acquire QP images on a high-speed flow microscope at 90-MHz line rates with <400 pixels per line. We also consider the extension of this technique to compressed sensing (CS) acquisition by intensity modulating the interference spectra with pseudorandom binary waveforms to reconstruct the images from a highly sub-Nyquist number of random inner products, providing a path to even higher operating rates and reduced data storage requirements.

Alaska SAR Facility (ASF5) SAR Communications (SARCOM) Data Compression System

NASA Technical Reports Server (NTRS)

Mango, Stephen A.

1989-01-01

The real-time operational requirements for SARCOM translation into a high speed image data handler and processor to achieve the desired compression ratios and the selection of a suitable image data compression technique with as low as possible fidelity (information) losses and which can be implemented in an algorithm placing a relatively low arithmetic load on the system are described.

OCT in the field of laryngology: further perspectives

NASA Astrophysics Data System (ADS)

Just, T.; Pau, H. W.; Lankenau, E.; Hüttmann, G.

2011-03-01

Early detection of cancerous lesions of the larynx may be the best method of improving patient quality of life and survival rates. New in-vivo technologies may be of great clinical relevance in improving the accuracy of sampling during microlaryngeal surgery. Optical coherence tomography (OCT) is an optical imaging technique that clearly identifies basement membrane violation caused by laryngeal cancer. With a microscope-based spectral domain OCT (SD-OCT) we reached in vivo a fairly accurate assessment of benign and dysplastic laryngeal lesions. Recent improvements in OCT technology have led to the development of high-speed OCT systems displaying millions of pixels per second. These systems allow non-contact real-time imaging of large sections of laryngeal tissue. Polarization contrast OCT (PS-OCT) may provide additional information about the lamina propria of the true vocal cord because of the birefringence of connective tissue. We present microscope-based high-speed SD-OCT images with and without polarization contrast and 3D volumes of selected laryngeal pathologies in order to demonstrate our current concepts for the intended intraoperative application. High-speed SD-OCT and polarization contrast can also be complemented by our recently developed rigid confocal endoscopic system to obtain cellular and sub-cellular information about the tissue. Further perspectives will be presented.

A Probability-Based Algorithm Using Image Sensors to Track the LED in a Vehicle Visible Light Communication System.

PubMed

Huynh, Phat; Do, Trong-Hop; Yoo, Myungsik

2017-02-10

This paper proposes a probability-based algorithm to track the LED in vehicle visible light communication systems using a camera. In this system, the transmitters are the vehicles' front and rear LED lights. The receivers are high speed cameras that take a series of images of the LEDs. ThedataembeddedinthelightisextractedbyfirstdetectingthepositionoftheLEDsintheseimages. Traditionally, LEDs are detected according to pixel intensity. However, when the vehicle is moving, motion blur occurs in the LED images, making it difficult to detect the LEDs. Particularly at high speeds, some frames are blurred at a high degree, which makes it impossible to detect the LED as well as extract the information embedded in these frames. The proposed algorithm relies not only on the pixel intensity, but also on the optical flow of the LEDs and on statistical information obtained from previous frames. Based on this information, the conditional probability that a pixel belongs to a LED is calculated. Then, the position of LED is determined based on this probability. To verify the suitability of the proposed algorithm, simulations are conducted by considering the incidents that can happen in a real-world situation, including a change in the position of the LEDs at each frame, as well as motion blur due to the vehicle speed.

A high resolution and high speed 3D imaging system and its application on ATR

NASA Astrophysics Data System (ADS)

Lu, Thomas T.; Chao, Tien-Hsin

2006-04-01

The paper presents an advanced 3D imaging system based on a combination of stereo vision and light projection methods. A single digital camera is used to take only one shot of the object and reconstruct the 3D model of an object. The stereo vision is achieved by employing a prism and mirror setup to split the views and combine them side by side in the camera. The advantage of this setup is its simple system architecture, easy synchronization, fast 3D imaging speed and high accuracy. The 3D imaging algorithms and potential applications are discussed. For ATR applications, it is critically important to extract maximum information for the potential targets and to separate the targets from the background and clutter noise. The added dimension of a 3D model provides additional features of surface profile, range information of the target. It is capable of removing the false shadow from camouflage and reveal the 3D profile of the object. It also provides arbitrary viewing angles and distances for training the filter bank for invariant ATR. The system architecture can be scaled to take large objects and to perform area 3D modeling onboard a UAV.

Burn depth determination using high-speed polarization-sensitive Mueller optical coherence tomography with continuous polarization modulation

NASA Astrophysics Data System (ADS)

Todorović, Miloš; Ai, Jun; Pereda Cubian, David; Stoica, George; Wang, Lihong

2006-02-01

National Health Interview Survey (NHIS) estimates more than 1.1 million burn injuries per year in the United States, with nearly 15,000 fatalities from wounds and related complications. An imaging modality capable of evaluating burn depths non-invasively is the polarization-sensitive optical coherence tomography. We report on the use of a high-speed, fiber-based Mueller-matrix OCT system with continuous source-polarization modulation for burn depth evaluation. The new system is capable of imaging at near video-quality frame rates (8 frames per second) with resolution of 10 μm in biological tissue (index of refraction: 1.4) and sensitivity of 78 dB. The sample arm optics is integrated in a hand-held probe simplifying the in vivo experiments. The applicability of the system for burn depth determination is demonstrated using biological samples of porcine tendon and porcine skin. The results show an improved imaging depth (1 mm in tendon) and a clear localization of the thermally damaged region. The burnt area determined from OCT images compares well with the histology, thus proving the system's potential for burn depth determination.

Advanced digital image archival system using MPEG technologies

NASA Astrophysics Data System (ADS)

Chang, Wo

2009-08-01

Digital information and records are vital to the human race regardless of the nationalities and eras in which they were produced. Digital image contents are produced at a rapid pace from cultural heritages via digitalization, scientific and experimental data via high speed imaging sensors, national defense satellite images from governments, medical and healthcare imaging records from hospitals, personal collection of photos from digital cameras. With these mass amounts of precious and irreplaceable data and knowledge, what standards technologies can be applied to preserve and yet provide an interoperable framework for accessing the data across varieties of systems and devices? This paper presents an advanced digital image archival system by applying the international standard of MPEG technologies to preserve digital image content.

Integrated editing system for Japanese text and image information "Linernote"

NASA Astrophysics Data System (ADS)

Tanaka, Kazuto

Integrated Japanese text editing system "Linernote" developed by Toyo Industries Co. is explained. The system has been developed on the concept of electronic publishing. It is composed of personal computer NEC PC-9801 VX and other peripherals. Sentence, drawing and image data is inputted and edited under the integrated operating environment in the system and final text is printed out by laser printer. Handling efficiency of time consuming work such as pattern input or page make up has been improved by draft image data indication method on CRT. It is the latest DTP system equipped with three major functions, namly, typesetting for high quality text editing, easy drawing/tracing and high speed image processing.

Determination of Shed Ice Particle Size Using High Speed Digital Imaging

NASA Technical Reports Server (NTRS)

Broughton, Howard; Owens, Jay; Sims, James J.; Bond, Thomas H.

1996-01-01

A full scale model of an aircraft engine inlet was tested at NASA Lewis Research Center's Icing Research Tunnel. Simulated natural ice sheds from the engine inlet lip were studied using high speed digital image acquisition and image analysis. Strategic camera placement integrated at the model design phase allowed the study of ice accretion on the inlet lip and the resulting shed ice particles at the aerodynamic interface plane at the rear of the inlet prior to engine ingestion. The resulting digital images were analyzed using commercial and proprietary software to determine the size of the ice particles that could potentially be ingested by the engine during a natural shedding event. A methodology was developed to calibrate the imaging system and insure consistent and accurate measurements of the ice particles for a wide range of icing conditions.

Ultra-fast quantitative imaging using ptychographic iterative engine based digital micro-mirror device

NASA Astrophysics Data System (ADS)

Sun, Aihui; Tian, Xiaolin; Kong, Yan; Jiang, Zhilong; Liu, Fei; Xue, Liang; Wang, Shouyu; Liu, Cheng

2018-01-01

As a lensfree imaging technique, ptychographic iterative engine (PIE) method can provide both quantitative sample amplitude and phase distributions avoiding aberration. However, it requires field of view (FoV) scanning often relying on mechanical translation, which not only slows down measuring speed, but also introduces mechanical errors decreasing both resolution and accuracy in retrieved information. In order to achieve high-accurate quantitative imaging with fast speed, digital micromirror device (DMD) is adopted in PIE for large FoV scanning controlled by on/off state coding by DMD. Measurements were implemented using biological samples as well as USAF resolution target, proving high resolution in quantitative imaging using the proposed system. Considering its fast and accurate imaging capability, it is believed the DMD based PIE technique provides a potential solution for medical observation and measurements.

The implementation of depth measurement and related algorithms based on binocular vision in embedded AM5728

NASA Astrophysics Data System (ADS)

Deng, Zhiwei; Li, Xicai; Shi, Junsheng; Huang, Xiaoqiao; Li, Feiyan

2018-01-01

Depth measurement is the most basic measurement in various machine vision, such as automatic driving, unmanned aerial vehicle (UAV), robot and so on. And it has a wide range of use. With the development of image processing technology and the improvement of hardware miniaturization and processing speed, real-time depth measurement using dual cameras has become a reality. In this paper, an embedded AM5728 and the ordinary low-cost dual camera is used as the hardware platform. The related algorithms of dual camera calibration, image matching and depth calculation have been studied and implemented on the hardware platform, and hardware design and the rationality of the related algorithms of the system are tested. The experimental results show that the system can realize simultaneous acquisition of binocular images, switching of left and right video sources, display of depth image and depth range. For images with a resolution of 640 × 480, the processing speed of the system can be up to 25 fps. The experimental results show that the optimal measurement range of the system is from 0.5 to 1.5 meter, and the relative error of the distance measurement is less than 5%. Compared with the PC, ARM11 and DMCU hardware platforms, the embedded AM5728 hardware is good at meeting real-time depth measurement requirements in ensuring the image resolution.

Laser scanning endoscope for diagnostic medicine

NASA Astrophysics Data System (ADS)

Ouimette, Donald R.; Nudelman, Sol; Spackman, Thomas; Zaccheo, Scott

1990-07-01

A new type of endoscope is being developed which utilizes an optical raster scanning system for imaging through an endoscope. The optical raster scanner utilizes a high speed, multifaceted, rotating polygon mirror system for horizontal deflection, and a slower speed galvanometer driven mirror as the vertical deflection system. When used in combination, the optical raster scanner traces out a raster similar to an electron beam raster used in television systems. This flying spot of light can then be detected by various types of photosensitive detectors to generate a video image of the surface or scene being illuminated by the scanning beam. The optical raster scanner has been coupled to an endoscope. The raster is projected down the endoscope, thereby illuminating the object to be imaged at the distal end of the endoscope. Elemental photodetectors are placed at the distal or proximal end of the endoscope to detect the reflected illumination from the flying spot of light. This time sequenced signal is captured by an image processor for display and processing. This technique offers the possibility for very small diameter endoscopes since illumination channel requirements are eliminated. Using various lasers, very specific spectral selectivity can be achieved to optimum contrast of specific lesions of interest. Using several laser lines, or a white light source, with detectors of specific spectral response, multiple spectrally selected images can be acquired simultaneously. The potential for co-linear therapy delivery while imaging is also possible.

Pulse-echo sound speed estimation using second order speckle statistics

NASA Astrophysics Data System (ADS)

Rosado-Mendez, Ivan M.; Nam, Kibo; Madsen, Ernest L.; Hall, Timothy J.; Zagzebski, James A.

2012-10-01

This work presents a phantom-based evaluation of a method for estimating soft-tissue speeds of sound using pulse-echo data. The method is based on the improvement of image sharpness as the sound speed value assumed during beamforming is systematically matched to the tissue sound speed. The novelty of this work is the quantitative assessment of image sharpness by measuring the resolution cell size from the autocovariance matrix for echo signals from a random distribution of scatterers thus eliminating the need of strong reflectors. Envelope data were obtained from a fatty-tissue mimicking (FTM) phantom (sound speed = 1452 m/s) and a nonfatty-tissue mimicking (NFTM) phantom (1544 m/s) scanned with a linear array transducer on a clinical ultrasound system. Dependence on pulse characteristics was tested by varying the pulse frequency and amplitude. On average, sound speed estimation errors were -0.7% for the FTM phantom and -1.1% for the NFTM phantom. In general, no significant difference was found among errors from different pulse frequencies and amplitudes. The method is currently being optimized for the differentiation of diffuse liver diseases.

Smartphone based scalable reverse engineering by digital image correlation

NASA Astrophysics Data System (ADS)

Vidvans, Amey; Basu, Saurabh

2018-03-01

There is a need for scalable open source 3D reconstruction systems for reverse engineering. This is because most commercially available reconstruction systems are capital and resource intensive. To address this, a novel reconstruction technique is proposed. The technique involves digital image correlation based characterization of surface speeds followed by normalization with respect to angular speed during rigid body rotational motion of the specimen. Proof of concept of the same is demonstrated and validated using simulation and empirical characterization. Towards this, smart-phone imaging and inexpensive off the shelf components along with those fabricated additively using poly-lactic acid polymer with a standard 3D printer are used. Some sources of error in this reconstruction methodology are discussed. It is seen that high curvatures on the surface suppress accuracy of reconstruction. Reasons behind this are delineated in the nature of the correlation function. Theoretically achievable resolution during smart-phone based 3D reconstruction by digital image correlation is derived.

A high-precision instrument for analyzing nonlinear dynamic behavior of bearing cage.

PubMed

Yang, Z; Chen, H; Yu, T; Li, B

2016-08-01

The high-precision ball bearing is fundamental to the performance of complex mechanical systems. As the speed increases, the cage behavior becomes a key factor in influencing the bearing performance, especially life and reliability. This paper develops a high-precision instrument for analyzing nonlinear dynamic behavior of the bearing cage. The trajectory of the rotational center and non-repetitive run-out (NRRO) of the cage are used to evaluate the instability of cage motion. This instrument applied an aerostatic spindle to support and spin test the bearing to decrease the influence of system error. Then, a high-speed camera is used to capture images when the bearing works at high speeds. A 3D trajectory tracking software tema Motion is used to track the spot which marked the cage surface. Finally, by developing the matlab program, a Lissajous' figure was used to evaluate the nonlinear dynamic behavior of the cage with different speeds. The trajectory of rotational center and NRRO of the cage with various speeds are analyzed. The results can be used to predict the initial failure and optimize cage structural parameters. In addition, the repeatability precision of instrument is also validated. In the future, the motorized spindle will be applied to increase testing speed and image processing algorithms will be developed to analyze the trajectory of the cage.

A high-precision instrument for analyzing nonlinear dynamic behavior of bearing cage

NASA Astrophysics Data System (ADS)

Yang, Z.; Chen, H.; Yu, T.; Li, B.

2016-08-01

The high-precision ball bearing is fundamental to the performance of complex mechanical systems. As the speed increases, the cage behavior becomes a key factor in influencing the bearing performance, especially life and reliability. This paper develops a high-precision instrument for analyzing nonlinear dynamic behavior of the bearing cage. The trajectory of the rotational center and non-repetitive run-out (NRRO) of the cage are used to evaluate the instability of cage motion. This instrument applied an aerostatic spindle to support and spin test the bearing to decrease the influence of system error. Then, a high-speed camera is used to capture images when the bearing works at high speeds. A 3D trajectory tracking software tema Motion is used to track the spot which marked the cage surface. Finally, by developing the matlab program, a Lissajous' figure was used to evaluate the nonlinear dynamic behavior of the cage with different speeds. The trajectory of rotational center and NRRO of the cage with various speeds are analyzed. The results can be used to predict the initial failure and optimize cage structural parameters. In addition, the repeatability precision of instrument is also validated. In the future, the motorized spindle will be applied to increase testing speed and image processing algorithms will be developed to analyze the trajectory of the cage.

A high-precision instrument for analyzing nonlinear dynamic behavior of bearing cage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Z., E-mail: zhaohui@nwpu.edu.cn; Yu, T.; Chen, H.

2016-08-15

The high-precision ball bearing is fundamental to the performance of complex mechanical systems. As the speed increases, the cage behavior becomes a key factor in influencing the bearing performance, especially life and reliability. This paper develops a high-precision instrument for analyzing nonlinear dynamic behavior of the bearing cage. The trajectory of the rotational center and non-repetitive run-out (NRRO) of the cage are used to evaluate the instability of cage motion. This instrument applied an aerostatic spindle to support and spin test the bearing to decrease the influence of system error. Then, a high-speed camera is used to capture images whenmore » the bearing works at high speeds. A 3D trajectory tracking software TEMA Motion is used to track the spot which marked the cage surface. Finally, by developing the MATLAB program, a Lissajous’ figure was used to evaluate the nonlinear dynamic behavior of the cage with different speeds. The trajectory of rotational center and NRRO of the cage with various speeds are analyzed. The results can be used to predict the initial failure and optimize cage structural parameters. In addition, the repeatability precision of instrument is also validated. In the future, the motorized spindle will be applied to increase testing speed and image processing algorithms will be developed to analyze the trajectory of the cage.« less

Local area networks in an imaging environment.

PubMed

Noz, M E; Maguire, G Q; Erdman, W A

1986-01-01

There is great interest at present in incorporating image-management systems popularly referred to as picture archiving and communication systems (PACS) into imaging departments. This paper will describe various aspects of local area networks (LANs) for medical images and will give a definition of terms and classification of devices by describing a possible system which links various digital image sources through a high-speed data link and a common image format, allows for viewing and processing of all images produced within the complex, and eliminates the transport of films. The status of standards governing LAN and particularly PACS systems along with a proposed image exchange format will be given. Prototype systems, particularly a system for nuclear medicine images, will be presented, as well as the prospects for the immediate future in terms of installations started and commercial products available. A survey of the many questions that arise in the development of a PACS for medical images and also a survey of the presently suggested/adopted answers will be given.

High-Speed Digital Scan Converter for High-Frequency Ultrasound Sector Scanners

PubMed Central

Chang, Jin Ho; Yen, Jesse T.; Shung, K. Kirk

2008-01-01

This paper presents a high-speed digital scan converter (DSC) capable of providing more than 400 images per second, which is necessary to examine the activities of the mouse heart whose rate is 5–10 beats per second. To achieve the desired high-speed performance in cost-effective manner, the DSC developed adopts a linear interpolation algorithm in which two nearest samples to each object pixel of a monitor are selected and only angular interpolation is performed. Through computer simulation with the Field II program, its accuracy was investigated by comparing it to that of bilinear interpolation known as the best algorithm in terms of accuracy and processing speed. The simulation results show that the linear interpolation algorithm is capable of providing an acceptable image quality, which means that the difference of the root mean square error (RMSE) values of the linear and bilinear interpolation algorithms is below 1 %, if the sample rate of the envelope samples is at least four times higher than the Nyquist rate for the baseband component of echo signals. The designed DSC was implemented with a single FPGA (Stratix EP1S60F1020C6, Altera Corporation, San Jose, CA) on a DSC board that is a part of a high-speed ultrasound imaging system developed. The temporal and spatial resolutions of the implemented DSC were evaluated by examining its maximum processing time with a time stamp indicating when an image is completely formed and wire phantom testing, respectively. The experimental results show that the implemented DSC is capable of providing images at the rate of 400 images per second with negligible processing error. PMID:18430449

TH-A-207B-00: Shear-Wave Imaging and a QIBA US Biomarker Update

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

Imaging of tissue elastic properties is a relatively new and powerful approach to one of the oldest and most important diagnostic tools. Imaging of shear wave speed with ultrasound is has been added to most high-end ultrasound systems. Understanding this exciting imaging mode aiding its most effective use in medicine can be a rewarding effort for medical physicists and other medical imaging and treatment professionals. Assuring consistent, quantitative measurements across the many ultrasound systems in a typical imaging department will constitute a major step toward realizing the great potential of this technique and other quantitative imaging. This session will targetmore » these two goals with two presentations. A. Basics and Current Implementations of Ultrasound Imaging of Shear Wave Speed and Elasticity - Shigao Chen, Ph.D. Learning objectives-To understand: Introduction: Importance of tissue elasticity measurement Strain vs. shear wave elastography (SWE), beneficial features of SWE The link between shear wave speed and material properties, influence of viscosity Generation of shear waves External vibration (Fibroscan) ultrasound radiation force Point push Supersonic push (Aixplorer) Comb push (GE Logiq E9) Detection of shear waves Motion detection from pulse-echo ultrasound Importance of frame rate for shear wave imaging Plane wave imaging detection How to achieve high effective frame rate using line-by-line scanners Shear wave speed calculation Time to peak Random sample consensus (RANSAC) Cross correlation Sources of bias and variation in SWE Tissue viscosity Transducer compression or internal pressure of organ Reflection of shear waves at boundaries B. Elasticity Imaging System Biomarker Qualification and User Testing of Systems – Brian Garra, M.D. Learning objectives-To understand: Goals Review the need for quantitative medical imaging Provide examples of quantitative imaging biomarkers Acquaint the participant with the purpose of the RSNA Quantitative Imaging Biomarker Alliance and the need for such an organization Review the QIBA process for creating a quantitative biomarker Summarize steps needed to verify adherence of site, operators, and imaging systems to a QIBA profile Underlying Premise and Assumptions Objective, quantifiable results are needed to enhance the value of diagnostic imaging in clinical practice Reasons for quantification Evidence based medicine requires objective, not subjective observer data Computerized decision support tools (eg CAD) generally require quantitative input. Quantitative, reproducible measures are more easily used to develop personalized molecular medical diagnostic and treatment systems What is quantitative imaging? Definition from Imaging Metrology Workshop The Quantitative Imaging Biomarker Alliance Formation 2008 Mission Structure Example Imaging Biomarkers Being Explored Biomarker Selection Groundwork Draft Protocol for imaging and data evaluation QIBA Profile Drafting Equipment and Site Validation Technical Clinical Site and Equipment QA and Compliance Checking Ultrasound Elasticity Estimation Biomarker US Elasticity Estimation Background Current Status and Problems Biomarker Selection-process and outcome US SWS for Liver Fibrosis Biomarker Work Groundwork Literature search and analysis results Phase I phantom testing-Elastic phantoms Phase II phantom testing-Viscoelastic phantoms Digital Simulated Data Protocol and Profile Drafting Protocol: based on UPICT and existing literature and standards bodies protocols Profile-Current claims, Manufacturer specific appendices What comes after the profile Profile Validation Technical validation Clinical validation QA and Compliance Possible approaches Site Operator testing Site protocol re-evaluation Imaging system Manufacturer testing and attestation User acceptance testing and periodic QA Phantom Tests Digital Phantom Based Testing Standard QA Testing Remediation Schemes Profile Evolution Towards additional applications Towards higher accuracy and precision Supported in part by NIH contract HHSN268201300071C from NIBIB. Collaboration with GE Global Research, no personal support.; S. Chen, Some technologies described in this presentation have been licensed. Mayo Clinic and Dr. Chen have financial interests these technologies.« less

Quantitative assessment of image motion blur in diffraction images of moving biological cells

NASA Astrophysics Data System (ADS)

Wang, He; Jin, Changrong; Feng, Yuanming; Qi, Dandan; Sa, Yu; Hu, Xin-Hua

2016-02-01

Motion blur (MB) presents a significant challenge for obtaining high-contrast image data from biological cells with a polarization diffraction imaging flow cytometry (p-DIFC) method. A new p-DIFC experimental system has been developed to evaluate the MB and its effect on image analysis using a time-delay-integration (TDI) CCD camera. Diffraction images of MCF-7 and K562 cells have been acquired with different speed-mismatch ratios and compared to characterize MB quantitatively. Frequency analysis of the diffraction images shows that the degree of MB can be quantified by bandwidth variations of the diffraction images along the motion direction. The analytical results were confirmed by the p-DIFC image data acquired at different speed-mismatch ratios and used to validate a method of numerical simulation of MB on blur-free diffraction images, which provides a useful tool to examine the blurring effect on diffraction images acquired from the same cell. These results provide insights on the dependence of diffraction image on MB and allow significant improvement on rapid biological cell assay with the p-DIFC method.

Wavelet-space correlation imaging for high-speed MRI without motion monitoring or data segmentation.

PubMed

Li, Yu; Wang, Hui; Tkach, Jean; Roach, David; Woods, Jason; Dumoulin, Charles

2015-12-01

This study aims to (i) develop a new high-speed MRI approach by implementing correlation imaging in wavelet-space, and (ii) demonstrate the ability of wavelet-space correlation imaging to image human anatomy with involuntary or physiological motion. Correlation imaging is a high-speed MRI framework in which image reconstruction relies on quantification of data correlation. The presented work integrates correlation imaging with a wavelet transform technique developed originally in the field of signal and image processing. This provides a new high-speed MRI approach to motion-free data collection without motion monitoring or data segmentation. The new approach, called "wavelet-space correlation imaging", is investigated in brain imaging with involuntary motion and chest imaging with free-breathing. Wavelet-space correlation imaging can exceed the speed limit of conventional parallel imaging methods. Using this approach with high acceleration factors (6 for brain MRI, 16 for cardiac MRI, and 8 for lung MRI), motion-free images can be generated in static brain MRI with involuntary motion and nonsegmented dynamic cardiac/lung MRI with free-breathing. Wavelet-space correlation imaging enables high-speed MRI in the presence of involuntary motion or physiological dynamics without motion monitoring or data segmentation. © 2014 Wiley Periodicals, Inc.

Rigorous accuracy assessment for 3D reconstruction using time-series Dual Fluoroscopy (DF) image pairs

NASA Astrophysics Data System (ADS)

Al-Durgham, Kaleel; Lichti, Derek D.; Kuntze, Gregor; Ronsky, Janet

2017-06-01

High-speed biplanar videoradiography, or clinically referred to as dual fluoroscopy (DF), imaging systems are being used increasingly for skeletal kinematics analysis. Typically, a DF system comprises two X-ray sources, two image intensifiers and two high-speed video cameras. The combination of these elements provides time-series image pairs of articulating bones of a joint, which permits the measurement of bony rotation and translation in 3D at high temporal resolution (e.g., 120-250 Hz). Assessment of the accuracy of 3D measurements derived from DF imaging has been the subject of recent research efforts by several groups, however with methodological limitations. This paper presents a novel and simple accuracy assessment procedure based on using precise photogrammetric tools. We address the fundamental photogrammetry principles for the accuracy evaluation of an imaging system. Bundle adjustment with selfcalibration is used for the estimation of the system parameters. The bundle adjustment calibration uses an appropriate sensor model and applies free-network constraints and relative orientation stability constraints for a precise estimation of the system parameters. A photogrammetric intersection of time-series image pairs is used for the 3D reconstruction of a rotating planar object. A point-based registration method is used to combine the 3D coordinates from the intersection and independently surveyed coordinates. The final DF accuracy measure is reported as the distance between 3D coordinates from image intersection and the independently surveyed coordinates. The accuracy assessment procedure is designed to evaluate the accuracy over the full DF image format and a wide range of object rotation. Experiment of reconstruction of a rotating planar object reported an average positional error of 0.44 +/- 0.2 mm in the derived 3D coordinates (minimum 0.05 and maximum 1.2 mm).

High-speed flow visualization in hypersonic, transonic, and shock tube flows

NASA Astrophysics Data System (ADS)

Kleine, H.; Olivier, H.

2017-02-01

High-speed flow visualisation has played an important role in the investigations conducted at the Stoßwellenlabor of the RWTH Aachen University for many decades. In addition to applying the techniques of high-speed imaging, this laboratory has been actively developing new or enhanced visualisation techniques and approaches such as various schlieren methods or time-resolved Mach-Zehnder interferometry. The investigated high-speed flows are inherently highly transient, with flow Mach numbers ranging from about M = 0.7 to M = 8. The availability of modern high-speed cameras has allowed us to expand the investigations into problems where reduced reproducibility had so far limited the amount of information that could be extracted from a limited number of flow visualisation records. Following a brief historical overview, some examples of recent studies are given, which represent the breadth of applications in which high-speed imaging has been an essential diagnostic tool to uncover the physics of high-speed flows. Applications include the stability of hypersonic corner flows, the establishment of shock wave systems in transonic airfoil flow, and the complexities of the interactions of shock waves with obstacles of various shapes.

Very High-Speed Digital Video Capability for In-Flight Use

NASA Technical Reports Server (NTRS)

Corda, Stephen; Tseng, Ting; Reaves, Matthew; Mauldin, Kendall; Whiteman, Donald

2006-01-01

digital video camera system has been qualified for use in flight on the NASA supersonic F-15B Research Testbed aircraft. This system is capable of very-high-speed color digital imaging at flight speeds up to Mach 2. The components of this system have been ruggedized and shock-mounted in the aircraft to survive the severe pressure, temperature, and vibration of the flight environment. The system includes two synchronized camera subsystems installed in fuselage-mounted camera pods (see Figure 1). Each camera subsystem comprises a camera controller/recorder unit and a camera head. The two camera subsystems are synchronized by use of an MHub(TradeMark) synchronization unit. Each camera subsystem is capable of recording at a rate up to 10,000 pictures per second (pps). A state-of-the-art complementary metal oxide/semiconductor (CMOS) sensor in the camera head has a maximum resolution of 1,280 1,024 pixels at 1,000 pps. Exposure times of the electronic shutter of the camera range from 1/200,000 of a second to full open. The recorded images are captured in a dynamic random-access memory (DRAM) and can be downloaded directly to a personal computer or saved on a compact flash memory card. In addition to the high-rate recording of images, the system can display images in real time at 30 pps. Inter Range Instrumentation Group (IRIG) time code can be inserted into the individual camera controllers or into the M-Hub unit. The video data could also be used to obtain quantitative, three-dimensional trajectory information. The first use of this system was in support of the Space Shuttle Return to Flight effort. Data were needed to help in understanding how thermally insulating foam is shed from a space shuttle external fuel tank during launch. The cameras captured images of simulated external tank debris ejected from a fixture mounted under the centerline of the F-15B aircraft. Digital video was obtained at subsonic and supersonic flight conditions, including speeds up to Mach 2 and altitudes up to 50,000 ft (15.24 km). The digital video was used to determine the structural survivability of the debris in a real flight environment and quantify the aerodynamic trajectories of the debris.

Compact opto-electronic engine for high-speed compressive sensing

NASA Astrophysics Data System (ADS)

Tidman, James; Weston, Tyler; Hewitt, Donna; Herman, Matthew A.; McMackin, Lenore

2013-09-01

The measurement efficiency of Compressive Sensing (CS) enables the computational construction of images from far fewer measurements than what is usually considered necessary by the Nyquist- Shannon sampling theorem. There is now a vast literature around CS mathematics and applications since the development of its theoretical principles about a decade ago. Applications include quantum information to optical microscopy to seismic and hyper-spectral imaging. In the application of shortwave infrared imaging, InView has developed cameras based on the CS single-pixel camera architecture. This architecture is comprised of an objective lens to image the scene onto a Texas Instruments DLP® Micromirror Device (DMD), which by using its individually controllable mirrors, modulates the image with a selected basis set. The intensity of the modulated image is then recorded by a single detector. While the design of a CS camera is straightforward conceptually, its commercial implementation requires significant development effort in optics, electronics, hardware and software, particularly if high efficiency and high-speed operation are required. In this paper, we describe the development of a high-speed CS engine as implemented in a lab-ready workstation. In this engine, configurable measurement patterns are loaded into the DMD at speeds up to 31.5 kHz. The engine supports custom reconstruction algorithms that can be quickly implemented. Our work includes optical path design, Field programmable Gate Arrays for DMD pattern generation, and circuit boards for front end data acquisition, ADC and system control, all packaged in a compact workstation.

Parallel fuzzy connected image segmentation on GPU

PubMed Central

Zhuge, Ying; Cao, Yong; Udupa, Jayaram K.; Miller, Robert W.

2011-01-01

Purpose: Image segmentation techniques using fuzzy connectedness (FC) principles have shown their effectiveness in segmenting a variety of objects in several large applications. However, one challenge in these algorithms has been their excessive computational requirements when processing large image datasets. Nowadays, commodity graphics hardware provides a highly parallel computing environment. In this paper, the authors present a parallel fuzzy connected image segmentation algorithm implementation on NVIDIA’s compute unified device Architecture (cuda) platform for segmenting medical image data sets. Methods: In the FC algorithm, there are two major computational tasks: (i) computing the fuzzy affinity relations and (ii) computing the fuzzy connectedness relations. These two tasks are implemented as cuda kernels and executed on GPU. A dramatic improvement in speed for both tasks is achieved as a result. Results: Our experiments based on three data sets of small, medium, and large data size demonstrate the efficiency of the parallel algorithm, which achieves a speed-up factor of 24.4x, 18.1x, and 10.3x, correspondingly, for the three data sets on the NVIDIA Tesla C1060 over the implementation of the algorithm on CPU, and takes 0.25, 0.72, and 15.04 s, correspondingly, for the three data sets. Conclusions: The authors developed a parallel algorithm of the widely used fuzzy connected image segmentation method on the NVIDIA GPUs, which are far more cost- and speed-effective than both cluster of workstations and multiprocessing systems. A near-interactive speed of segmentation has been achieved, even for the large data set. PMID:21859037

Parallel fuzzy connected image segmentation on GPU.

PubMed

Zhuge, Ying; Cao, Yong; Udupa, Jayaram K; Miller, Robert W

2011-07-01

Image segmentation techniques using fuzzy connectedness (FC) principles have shown their effectiveness in segmenting a variety of objects in several large applications. However, one challenge in these algorithms has been their excessive computational requirements when processing large image datasets. Nowadays, commodity graphics hardware provides a highly parallel computing environment. In this paper, the authors present a parallel fuzzy connected image segmentation algorithm implementation on NVIDIA's compute unified device Architecture (CUDA) platform for segmenting medical image data sets. In the FC algorithm, there are two major computational tasks: (i) computing the fuzzy affinity relations and (ii) computing the fuzzy connectedness relations. These two tasks are implemented as CUDA kernels and executed on GPU. A dramatic improvement in speed for both tasks is achieved as a result. Our experiments based on three data sets of small, medium, and large data size demonstrate the efficiency of the parallel algorithm, which achieves a speed-up factor of 24.4x, 18.1x, and 10.3x, correspondingly, for the three data sets on the NVIDIA Tesla C1060 over the implementation of the algorithm on CPU, and takes 0.25, 0.72, and 15.04 s, correspondingly, for the three data sets. The authors developed a parallel algorithm of the widely used fuzzy connected image segmentation method on the NVIDIA GPUs, which are far more cost- and speed-effective than both cluster of workstations and multiprocessing systems. A near-interactive speed of segmentation has been achieved, even for the large data set.

Spectrum slicer for snapshot spectral imaging

NASA Astrophysics Data System (ADS)

Tamamitsu, Miu; Kitagawa, Yutaro; Nakagawa, Keiichi; Horisaki, Ryoichi; Oishi, Yu; Morita, Shin-ya; Yamagata, Yutaka; Motohara, Kentaro; Goda, Keisuke

2015-12-01

We propose and demonstrate an optical component that overcomes critical limitations in our previously demonstrated high-speed multispectral videography-a method in which an array of periscopes placed in a prism-based spectral shaper is used to achieve snapshot multispectral imaging with the frame rate only limited by that of an image-recording sensor. The demonstrated optical component consists of a slicing mirror incorporated into a 4f-relaying lens system that we refer to as a spectrum slicer (SS). With its simple design, we can easily increase the number of spectral channels without adding fabrication complexity while preserving the capability of high-speed multispectral videography. We present a theoretical framework for the SS and its experimental utility to spectral imaging by showing real-time monitoring of a dynamic colorful event through five different visible windows.

A comparison of the imaging characteristics of the new Kodak Hyper Speed G film with the current T-MAT G/RA film and the CR 9000 system.

PubMed

Monnin, P; Gutierrez, D; Bulling, S; Lepori, D; Verdun, F R

2005-10-07

Three standard radiation qualities (RQA 3, RQA 5 and RQA 9) and two screens, Kodak Lanex Regular and Insight Skeletal, were used to compare the imaging performance and dose requirements of the new Kodak Hyper Speed G and the current Kodak T-MAT G/RA medical x-ray films. The noise equivalent quanta (NEQ) and detective quantum efficiencies (DQE) of the four screen-film combinations were measured at three gross optical densities and compared with the characteristics for the Kodak CR 9000 system with GP (general purpose) and HR (high resolution) phosphor plates. The new Hyper Speed G film has double the intrinsic sensitivity of the T-MAT G/RA film and a higher contrast in the high optical density range for comparable exposure latitude. By providing both high sensitivity and high spatial resolution, the new film significantly improves the compromise between dose and image quality. As expected, the new film has a higher noise level and a lower signal-to-noise ratio than the standard film, although in the high frequency range this is compensated for by a better resolution, giving better DQE results--especially at high optical density. Both screen-film systems outperform the phosphor plates in terms of MTF and DQE for standard imaging conditions (Regular screen at RQA 5 and RQA 9 beam qualities). At low energy (RQA 3), the CR system has a comparable low-frequency DQE to screen-film systems when used with a fine screen at low and middle optical densities, and a superior low-frequency DQE at high optical density.

Test and Verification of AES Used for Image Encryption

NASA Astrophysics Data System (ADS)

Zhang, Yong

2018-03-01

In this paper, an image encryption program based on AES in cipher block chaining mode was designed with C language. The encryption/decryption speed and security performance of AES based image cryptosystem were tested and used to compare the proposed cryptosystem with some existing image cryptosystems based on chaos. Simulation results show that AES can apply to image encryption, which refutes the widely accepted point of view that AES is not suitable for image encryption. This paper also suggests taking the speed of AES based image encryption as the speed benchmark of image encryption algorithms. And those image encryption algorithms whose speeds are lower than the benchmark should be discarded in practical communications.

Development of a high-speed VCSEL OCT system for real-time imaging of conscious patients larynx using a hand-held probe (Conference Presentation)

NASA Astrophysics Data System (ADS)

Rangarajan, Swathi; Chou, Li-Dek; Coughlan, Carolyn; Sharma, Giriraj; Wong, Brian J. F.; Ramalingam, Tirunelveli S.

2016-02-01

Fourier domain optical coherence tomography (FD-OCT) is a noninvasive imaging modality that has previously been used to image the human larynx. However, differences in anatomical geometry and short imaging range of conventional OCT limits its application in a clinical setting. In order to address this issue, we have developed a gradient-index (GRIN) lens rod-based hand-held probe in conjunction with a long imaging range 200 kHz Vertical-Cavity Surface Emitting Lasers (VCSEL) swept-source optical coherence tomography (SS-OCT) system for high speed real-time imaging of the human larynx in an office setting. This hand-held probe is designed to have a long and dynamically tunable working distance to accommodate the differences in anatomical geometry of human test subjects. A nominal working distance (~6 cm) of the probe is selected to have a lateral resolution <100 um within a depth of focus of 6.4 mm, which covers more than half of the 12 mm imaging range of the VCSEL laser. The maximum lateral scanning range of the probe at 6 cm working distance is approximately 8.4 mm, and imaging an area of 8.5 mm by 8.5 mm is accomplished within a second. Using the above system, we will demonstrate real-time cross-sectional OCT imaging of larynx during phonation in vivo in human and ex-vivo in pig vocal folds.

Dynamic displacement measurement of large-scale structures based on the Lucas-Kanade template tracking algorithm

NASA Astrophysics Data System (ADS)

Guo, Jie; Zhu, Chang`an

2016-01-01

The development of optics and computer technologies enables the application of the vision-based technique that uses digital cameras to the displacement measurement of large-scale structures. Compared with traditional contact measurements, vision-based technique allows for remote measurement, has a non-intrusive characteristic, and does not necessitate mass introduction. In this study, a high-speed camera system is developed to complete the displacement measurement in real time. The system consists of a high-speed camera and a notebook computer. The high-speed camera can capture images at a speed of hundreds of frames per second. To process the captured images in computer, the Lucas-Kanade template tracking algorithm in the field of computer vision is introduced. Additionally, a modified inverse compositional algorithm is proposed to reduce the computing time of the original algorithm and improve the efficiency further. The modified algorithm can rapidly accomplish one displacement extraction within 1 ms without having to install any pre-designed target panel onto the structures in advance. The accuracy and the efficiency of the system in the remote measurement of dynamic displacement are demonstrated in the experiments on motion platform and sound barrier on suspension viaduct. Experimental results show that the proposed algorithm can extract accurate displacement signal and accomplish the vibration measurement of large-scale structures.

Velocity Measurement Systems for a Low-speed Wind Tunnel

DTIC Science & Technology

2015-04-29

Office P.O. Box 12211 Research Triangle Park, NC 27709-2211 wind tunnel PIV hot wire particle image velocimetry REPORT DOCUMENTATION PAGE 11. SPONSOR...Velocity Measurement Systems for a Low-speed Wind Tunnel Report Title Funds were provided by the ARO for the purchase of TSI hot- wire anemometer equipment...implemented. In the summer of 2011, the focus of the summer camp was on wind turbines , and for the last two summers, the STEM outreach camp has studied

Wavelet-space Correlation Imaging for High-speed MRI without Motion Monitoring or Data Segmentation

PubMed Central

Li, Yu; Wang, Hui; Tkach, Jean; Roach, David; Woods, Jason; Dumoulin, Charles

2014-01-01

Purpose This study aims to 1) develop a new high-speed MRI approach by implementing correlation imaging in wavelet-space, and 2) demonstrate the ability of wavelet-space correlation imaging to image human anatomy with involuntary or physiological motion. Methods Correlation imaging is a high-speed MRI framework in which image reconstruction relies on quantification of data correlation. The presented work integrates correlation imaging with a wavelet transform technique developed originally in the field of signal and image processing. This provides a new high-speed MRI approach to motion-free data collection without motion monitoring or data segmentation. The new approach, called “wavelet-space correlation imaging”, is investigated in brain imaging with involuntary motion and chest imaging with free-breathing. Results Wavelet-space correlation imaging can exceed the speed limit of conventional parallel imaging methods. Using this approach with high acceleration factors (6 for brain MRI, 16 for cardiac MRI and 8 for lung MRI), motion-free images can be generated in static brain MRI with involuntary motion and nonsegmented dynamic cardiac/lung MRI with free-breathing. Conclusion Wavelet-space correlation imaging enables high-speed MRI in the presence of involuntary motion or physiological dynamics without motion monitoring or data segmentation. PMID:25470230

Real-time Awake Animal Motion Tracking System for SPECT Imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goddard Jr, James Samuel; Baba, Justin S; Lee, Seung Joon

Enhancements have been made in the development of a real-time optical pose measurement and tracking system that provides 3D position and orientation data for a single photon emission computed tomography (SPECT) imaging system for awake, unanesthetized, unrestrained small animals. Three optical cameras with infrared (IR) illumination view the head movements of an animal enclosed in a transparent burrow. Markers placed on the head provide landmark points for image segmentation. Strobed IR LED s are synchronized to the cameras and illuminate the markers to prevent motion blur for each set of images. The system using the three cameras automatically segments themore » markers, detects missing data, rejects false reflections, performs trinocular marker correspondence, and calculates the 3D pose of the animal s head. Improvements have been made in methods for segmentation, tracking, and 3D calculation to give higher speed and more accurate measurements during a scan. The optical hardware has been installed within a Siemens MicroCAT II small animal scanner at Johns Hopkins without requiring functional changes to the scanner operation. The system has undergone testing using both phantoms and live mice and has been characterized in terms of speed, accuracy, robustness, and reliability. Experimental data showing these motion tracking results are given.« less

Quasi-real-time telemedical checkup system for x-ray examination of UGI tract based on high-speed network

NASA Astrophysics Data System (ADS)

Sakano, Toshikazu; Yamaguchi, Takahiro; Fujii, Tatsuya; Okumura, Akira; Furukawa, Isao; Ono, Sadayasu; Suzuki, Junji; Ando, Yutaka; Kohda, Ehiichi; Sugino, Yoshinori; Okada, Yoshiyuki; Amaki, Sachi

2000-05-01

We constructed a high-speed medical information network testbed, which is one of the largest testbeds in Japan, and applied it to practical medical checkups for the first time. The constructed testbed, which we call IMPACT, consists of a Super-High Definition Imaging system, a video conferencing system, a remote database system, and a 6 - 135 Mbps ATM network. The interconnected facilities include the School of Medicine in Keio University, a company's clinic, and an NTT R&D center, all in and around Tokyo. We applied IMPACT to the mass screening of the upper gastrointestinal (UGI) tract at the clinic. All 5419 radiographic images acquired at them clinic for 523 employees were digitized (2048 X 1698 X 12 bits) and transferred to a remote database in NTT. We then picked up about 50 images from five patients and sent them to nine radiological specialists at Keio University. The processing, which includes film digitization, image data transfer, and database registration, took 574 seconds per patient in average. The average reading time at Keio Univ. was 207 seconds. The overall processing time was estimated to be 781 seconds per patient. From these experimental results, we conclude that quasi-real time tele-medical checkups are possible with our prototype system.

Study on the high-frequency laser measurement of slot surface difference

NASA Astrophysics Data System (ADS)

Bing, Jia; Lv, Qiongying; Cao, Guohua

2017-10-01

In view of the measurement of the slot surface difference in the large-scale mechanical assembly process, Based on high frequency laser scanning technology and laser detection imaging principle, This paragraph designs a double galvanometer pulse laser scanning system. Laser probe scanning system architecture consists of three parts: laser ranging part, mechanical scanning part, data acquisition and processing part. The part of laser range uses high-frequency laser range finder to measure the distance information of the target shape and get a lot of point cloud data. Mechanical scanning part includes high-speed rotary table, high-speed transit and related structure design, in order to realize the whole system should be carried out in accordance with the design of scanning path on the target three-dimensional laser scanning. Data processing part mainly by FPGA hardware with LAbVIEW software to design a core, to process the point cloud data collected by the laser range finder at the high-speed and fitting calculation of point cloud data, to establish a three-dimensional model of the target, so laser scanning imaging is realized.

Development of high definition OCT system for clinical therapy of skin diseases

NASA Astrophysics Data System (ADS)

Baek, Daeyul; Seo, Young-Seok; Kim, Jung-Hyun

2018-02-01

OCT is a non-invasive imaging technique that can be applied to diagnose various skin disease. Since its introduction in 1997, dermatology has used OCT technology to obtain high quality images of human skin. Recently, in order to accurately diagnose skin diseases, it is essential to develop OCT equipment that can obtain high quality images. Therefore, we developed the system that can obtain a high quality image by using a 1300 nm light source with a wide bandwidth and deep penetration depth, high-resolution image, and a camera capable of high sensitivity and high speed processing. We introduce the performance of the developed system and the clinical application data.

Teaching high-speed photography and photo-instrumentation

NASA Astrophysics Data System (ADS)

Davidhazy, Andrew

2005-03-01

As the tools available to the high speed photographer have become more powerful the underlying technology has increased in complexity and often is beyond the reach of most practitioners in terms of in-the-field troubleshooting or adaptation and this specialization has also driven many systems beyond the reach of high school, community college and undergraduate, non-research funded, universities. In spite of this and with the belief that fundamental techniques, reasoning and approaches have not changed much over the years, several courses in photo-instrumentation at the Imaging and Photographic Technology program at the Rochester Institute of Technology present to a couple dozen undergraduate students a year the principles associated with a various imaging systems and techniques for visualization and data analysis of high speed or "invisible" phenomena. This paper reviews the objectives and philosophy of these courses in the context of a total imaging technology education. It describes and illustrates current topics included in the program. In brief, calibration and time measurement concepts, instantaneous and repetitive time sampling equipment, various visualization technologies, strip and streak cameras and applications using film and improvised digital recorders, basic velocimetry techniques including sensitometric velocimetry and synchro-ballistic photography plus other related techniques are introduced to undergraduate students.

Coincidence ion imaging with a fast frame camera

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Suk Kyoung; Cudry, Fadia; Lin, Yun Fei

2014-12-15

A new time- and position-sensitive particle detection system based on a fast frame CMOS (complementary metal-oxide semiconductors) camera is developed for coincidence ion imaging. The system is composed of four major components: a conventional microchannel plate/phosphor screen ion imager, a fast frame CMOS camera, a single anode photomultiplier tube (PMT), and a high-speed digitizer. The system collects the positional information of ions from a fast frame camera through real-time centroiding while the arrival times are obtained from the timing signal of a PMT processed by a high-speed digitizer. Multi-hit capability is achieved by correlating the intensity of ion spots onmore » each camera frame with the peak heights on the corresponding time-of-flight spectrum of a PMT. Efficient computer algorithms are developed to process camera frames and digitizer traces in real-time at 1 kHz laser repetition rate. We demonstrate the capability of this system by detecting a momentum-matched co-fragments pair (methyl and iodine cations) produced from strong field dissociative double ionization of methyl iodide.« less

Digital image processing of bone - Problems and potentials

NASA Technical Reports Server (NTRS)

Morey, E. R.; Wronski, T. J.

1980-01-01

The development of a digital image processing system for bone histomorphometry and fluorescent marker monitoring is discussed. The system in question is capable of making measurements of UV or light microscope features on a video screen with either video or computer-generated images, and comprises a microscope, low-light-level video camera, video digitizer and display terminal, color monitor, and PDP 11/34 computer. Capabilities demonstrated in the analysis of an undecalcified rat tibia include the measurement of perimeter and total bone area, and the generation of microscope images, false color images, digitized images and contoured images for further analysis. Software development will be based on an existing software library, specifically the mini-VICAR system developed at JPL. It is noted that the potentials of the system in terms of speed and reliability far exceed any problems associated with hardware and software development.

Qualitative and quantitative imaging in microgravity combustion

NASA Technical Reports Server (NTRS)

Weiland, Karen J.

1995-01-01

An overview of the imaging techniques implemented by researchers in the microgravity combustion program shows that for almost any system, imaging of the flame may be accomplished in a variety of ways. Standard and intensified video, high speed, and infrared cameras and fluorescence, laser schlieren, rainbow schlieren, soot volume fraction, and soot temperature imaging have all been used in the laboratory and many in reduced gravity to make the necessary experimental measurements.

A FPGA-based architecture for real-time image matching

NASA Astrophysics Data System (ADS)

Wang, Jianhui; Zhong, Sheng; Xu, Wenhui; Zhang, Weijun; Cao, Zhiguo

2013-10-01

Image matching is a fundamental task in computer vision. It is used to establish correspondence between two images taken at different viewpoint or different time from the same scene. However, its large computational complexity has been a challenge to most embedded systems. This paper proposes a single FPGA-based image matching system, which consists of SIFT feature detection, BRIEF descriptor extraction and BRIEF matching. It optimizes the FPGA architecture for the SIFT feature detection to reduce the FPGA resources utilization. Moreover, we implement BRIEF description and matching on FPGA also. The proposed system can implement image matching at 30fps (frame per second) for 1280x720 images. Its processing speed can meet the demand of most real-life computer vision applications.

Electronic imaging system and technique

DOEpatents

Bolstad, J.O.

1984-06-12

A method and system for viewing objects obscurred by intense plasmas or flames (such as a welding arc) includes a pulsed light source to illuminate the object, the peak brightness of the light reflected from the object being greater than the brightness of the intense plasma or flame; an electronic image sensor for detecting a pulsed image of the illuminated object, the sensor being operated as a high-speed shutter; and electronic means for synchronizing the shutter operation with the pulsed light source.

Electronic imaging system and technique

DOEpatents

Bolstad, Jon O.

1987-01-01

A method and system for viewing objects obscurred by intense plasmas or flames (such as a welding arc) includes a pulsed light source to illuminate the object, the peak brightness of the light reflected from the object being greater than the brightness of the intense plasma or flame; an electronic image sensor for detecting a pulsed image of the illuminated object, the sensor being operated as a high-speed shutter; and electronic means for synchronizing the shutter operation with the pulsed light source.

High Resolution Trichromatic Road Surface Scanning with a Line Scan Camera and Light Emitting Diode Lighting for Road-Kill Detection.

PubMed

Lopes, Gil; Ribeiro, A Fernando; Sillero, Neftalí; Gonçalves-Seco, Luís; Silva, Cristiano; Franch, Marc; Trigueiros, Paulo

2016-04-19

This paper presents a road surface scanning system that operates with a trichromatic line scan camera with light emitting diode (LED) lighting achieving road surface resolution under a millimeter. It was part of a project named Roadkills-Intelligent systems for surveying mortality of amphibians in Portuguese roads, sponsored by the Portuguese Science and Technology Foundation. A trailer was developed in order to accommodate the complete system with standalone power generation, computer image capture and recording, controlled lighting to operate day or night without disturbance, incremental encoder with 5000 pulses per revolution attached to one of the trailer wheels, under a meter Global Positioning System (GPS) localization, easy to utilize with any vehicle with a trailer towing system and focused on a complete low cost solution. The paper describes the system architecture of the developed prototype, its calibration procedure, the performed experimentation and some obtained results, along with a discussion and comparison with existing systems. Sustained operating trailer speeds of up to 30 km/h are achievable without loss of quality at 4096 pixels' image width (1 m width of road surface) with 250 µm/pixel resolution. Higher scanning speeds can be achieved by lowering the image resolution (120 km/h with 1 mm/pixel). Computer vision algorithms are under development to operate on the captured images in order to automatically detect road-kills of amphibians.

High Resolution Trichromatic Road Surface Scanning with a Line Scan Camera and Light Emitting Diode Lighting for Road-Kill Detection

PubMed Central

Lopes, Gil; Ribeiro, A. Fernando; Sillero, Neftalí; Gonçalves-Seco, Luís; Silva, Cristiano; Franch, Marc; Trigueiros, Paulo

2016-01-01

This paper presents a road surface scanning system that operates with a trichromatic line scan camera with light emitting diode (LED) lighting achieving road surface resolution under a millimeter. It was part of a project named Roadkills—Intelligent systems for surveying mortality of amphibians in Portuguese roads, sponsored by the Portuguese Science and Technology Foundation. A trailer was developed in order to accommodate the complete system with standalone power generation, computer image capture and recording, controlled lighting to operate day or night without disturbance, incremental encoder with 5000 pulses per revolution attached to one of the trailer wheels, under a meter Global Positioning System (GPS) localization, easy to utilize with any vehicle with a trailer towing system and focused on a complete low cost solution. The paper describes the system architecture of the developed prototype, its calibration procedure, the performed experimentation and some obtained results, along with a discussion and comparison with existing systems. Sustained operating trailer speeds of up to 30 km/h are achievable without loss of quality at 4096 pixels’ image width (1 m width of road surface) with 250 µm/pixel resolution. Higher scanning speeds can be achieved by lowering the image resolution (120 km/h with 1 mm/pixel). Computer vision algorithms are under development to operate on the captured images in order to automatically detect road-kills of amphibians. PMID:27104535

High-sensitivity, high-speed continuous imaging system

DOEpatents

Watson, Scott A; Bender, III, Howard A

2014-11-18

A continuous imaging system for recording low levels of light typically extending over small distances with high-frame rates and with a large number of frames is described. Photodiode pixels disposed in an array having a chosen geometry, each pixel having a dedicated amplifier, analog-to-digital convertor, and memory, provide parallel operation of the system. When combined with a plurality of scintillators responsive to a selected source of radiation, in a scintillator array, the light from each scintillator being directed to a single corresponding photodiode in close proximity or lens-coupled thereto, embodiments of the present imaging system may provide images of x-ray, gamma ray, proton, and neutron sources with high efficiency.

Hyperspectral imaging using the single-pixel Fourier transform technique

NASA Astrophysics Data System (ADS)

Jin, Senlin; Hui, Wangwei; Wang, Yunlong; Huang, Kaicheng; Shi, Qiushuai; Ying, Cuifeng; Liu, Dongqi; Ye, Qing; Zhou, Wenyuan; Tian, Jianguo

2017-03-01

Hyperspectral imaging technology is playing an increasingly important role in the fields of food analysis, medicine and biotechnology. To improve the speed of operation and increase the light throughput in a compact equipment structure, a Fourier transform hyperspectral imaging system based on a single-pixel technique is proposed in this study. Compared with current imaging spectrometry approaches, the proposed system has a wider spectral range (400-1100 nm), a better spectral resolution (1 nm) and requires fewer measurement data (a sample rate of 6.25%). The performance of this system was verified by its application to the non-destructive testing of potatoes.

Relationship between breast sound speed and mammographic percent density

NASA Astrophysics Data System (ADS)

Sak, Mark; Duric, Nebojsa; Boyd, Norman; Littrup, Peter; Myc, Lukasz; Faiz, Muhammad; Li, Cuiping; Bey-Knight, Lisa

2011-03-01

Despite some shortcomings, mammography is currently the standard of care for breast cancer screening and diagnosis. However, breast ultrasound tomography is a rapidly developing imaging modality that has the potential to overcome the drawbacks of mammography. It is known that women with high breast densities have a greater risk of developing breast cancer. Measuring breast density is accomplished through the use of mammographic percent density, defined as the ratio of fibroglandular to total breast area. Using an ultrasound tomography (UST) prototype, we created sound speed images of the patient's breast, motivated by the fact that sound speed in a tissue is proportional to the density of the tissue. The purpose of this work is to compare the acoustic performance of the UST system with the measurement of mammographic percent density. A cohort of 251 patients was studied using both imaging modalities and the results suggest that the volume averaged breast sound speed is significantly related to mammographic percent density. The Spearman correlation coefficient was found to be 0.73 for the 175 film mammograms and 0.69 for the 76 digital mammograms obtained. Since sound speed measurements do not require ionizing radiation or physical compression, they have the potential to form the basis of a safe, more accurate surrogate marker of breast density.

Optical resolution photoacoustic microscopy using novel high-repetition-rate passively Q-switched microchip and fiber lasers.

PubMed

Shi, Wei; Kerr, Shaun; Utkin, Ilya; Ranasinghesagara, Janaka; Pan, Lei; Godwal, Yogesh; Zemp, Roger J; Fedosejevs, Robert

2010-01-01

Optical-resolution photoacoustic microscopy (OR-PAM) is a novel imaging technology for visualizing optically absorbing superficial structures in vivo with lateral spatial resolution determined by optical focusing rather than acoustic detection. Since scanning of the illumination spot is required, OR-PAM imaging speed is limited by both scanning speed and laser pulse repetition rate. Unfortunately, lasers with high repetition rates and suitable pulse durations and energies are not widely available and can be cost-prohibitive and bulky. We are developing compact, passively Q-switched fiber and microchip laser sources for this application. The properties of these lasers are discussed, and pulse repetition rates up to 100 kHz are demonstrated. OR-PAM imaging was conducted using a previously developed photoacoustic probe, which enabled flexible scanning of the focused output of the lasers. Phantom studies demonstrate the ability to image with lateral spatial resolution of 7±2 μm with the microchip laser system and 15±5 μm with the fiber laser system. We believe that the high pulse repetition rates and the potentially compact and fiber-coupled nature of these lasers will prove important for clinical imaging applications where real-time imaging performance is essential.

Note: An improved 3D imaging system for electron-electron coincidence measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lin, Yun Fei; Lee, Suk Kyoung; Adhikari, Pradip

We demonstrate an improved imaging system that can achieve highly efficient 3D detection of two electrons in coincidence. The imaging system is based on a fast frame complementary metal-oxide semiconductor camera and a high-speed waveform digitizer. We have shown previously that this detection system is capable of 3D detection of ions and electrons with good temporal and spatial resolution. Here, we show that with a new timing analysis algorithm, this system can achieve an unprecedented dead-time (<0.7 ns) and dead-space (<1 mm) when detecting two electrons. A true zero dead-time detection is also demonstrated.

Note: An improved 3D imaging system for electron-electron coincidence measurements

NASA Astrophysics Data System (ADS)

Lin, Yun Fei; Lee, Suk Kyoung; Adhikari, Pradip; Herath, Thushani; Lingenfelter, Steven; Winney, Alexander H.; Li, Wen

2015-09-01

We demonstrate an improved imaging system that can achieve highly efficient 3D detection of two electrons in coincidence. The imaging system is based on a fast frame complementary metal-oxide semiconductor camera and a high-speed waveform digitizer. We have shown previously that this detection system is capable of 3D detection of ions and electrons with good temporal and spatial resolution. Here, we show that with a new timing analysis algorithm, this system can achieve an unprecedented dead-time (<0.7 ns) and dead-space (<1 mm) when detecting two electrons. A true zero dead-time detection is also demonstrated.

Real-time digital signal processing for live electro-optic imaging.

PubMed

Sasagawa, Kiyotaka; Kanno, Atsushi; Tsuchiya, Masahiro

2009-08-31

We present an imaging system that enables real-time magnitude and phase detection of modulated signals and its application to a Live Electro-optic Imaging (LEI) system, which realizes instantaneous visualization of RF electric fields. The real-time acquisition of magnitude and phase images of a modulated optical signal at 5 kHz is demonstrated by imaging with a Si-based high-speed CMOS image sensor and real-time signal processing with a digital signal processor. In the LEI system, RF electric fields are probed with light via an electro-optic crystal plate and downconverted to an intermediate frequency by parallel optical heterodyning, which can be detected with the image sensor. The artifacts caused by the optics and the image sensor characteristics are corrected by image processing. As examples, we demonstrate real-time visualization of electric fields from RF circuits.

Ultrasound Imaging Using Diffraction Tomography in a Cylindrical Geometry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chambers, D H; Littrup, P

2002-01-24

Tomographic images of tissue phantoms and a sample of breast tissue have been produced from an acoustic synthetic array system for frequencies near 500 kHz. The images for sound speed and attenuation show millimeter resolution and demonstrate the feasibility of obtaining high-resolution tomographic images with frequencies that can deeply penetrate tissue. The image reconstruction method is based on the Born approximation to acoustic scattering and is a simplified version of a method previously used by Andre (Andre, et. al., Int. J. Imaging Systems and Technology, Vol 8, No. 1, 1997) for a circular acoustic array system. The images have comparablemore » resolution to conventional ultrasound images at much higher frequencies (3-5 MHz) but with lower speckle noise. This shows the potential of low frequency, deeply penetrating, ultrasound for high-resolution quantitative imaging.« less

HERMES: a high-speed radar imaging system for inspection of bridge decks

NASA Astrophysics Data System (ADS)

Azevedo, Stephen G.; Mast, Jeffrey E.; Nelson, Scott D.; Rosenbury, E. T.; Jones, Holger E.; McEwan, Thomas E.; Mullenhoff, D. J.; Hugenberger, R. E.; Stever, R. D.; Warhus, John P.; Wieting, Mel G.

1996-11-01

Corrosion of rebar in concrete bridges causes subsurface cracks and is a major cause of structural degradation that necessitates repair or replacement. Early detection of corrosion effects can limit the location and extent of necessary repairs, while providing long-term information about the infrastructure status. Most current detection methods, however, are destructive of the road surface and require closing or restricting traffic while the tests are performed. A ground-penetrating radar imaging system has been designed and developed that will perform the nondestructive evaluation of road-bed cracking at traffic speeds, i.e., without the need to restrict traffic flow. The first-generation system consists of an offset-linear array of 64 impulse radar transceivers and associated electronics housed in a trailer. Computers in the trailer and in the towing vehicle control the data acquisition, processing, and display. Cross-road resolution is three centimeters at up to 30 cm in depth, while down-road resolution depends on speed; 3 cm below 20 mph up to 8 cm at 50 mph. A two-meter-wide path is inspected on each pass over the roadway. In this paper, we describe the design of this system, show preliminary results, and lay out its deployment schedule.

Rapid and highly integrated FPGA-based Shack-Hartmann wavefront sensor for adaptive optics system

NASA Astrophysics Data System (ADS)

Chen, Yi-Pin; Chang, Chia-Yuan; Chen, Shean-Jen

2018-02-01

In this study, a field programmable gate array (FPGA)-based Shack-Hartmann wavefront sensor (SHWS) programmed on LabVIEW can be highly integrated into customized applications such as adaptive optics system (AOS) for performing real-time wavefront measurement. Further, a Camera Link frame grabber embedded with FPGA is adopted to enhance the sensor speed reacting to variation considering its advantage of the highest data transmission bandwidth. Instead of waiting for a frame image to be captured by the FPGA, the Shack-Hartmann algorithm are implemented in parallel processing blocks design and let the image data transmission synchronize with the wavefront reconstruction. On the other hand, we design a mechanism to control the deformable mirror in the same FPGA and verify the Shack-Hartmann sensor speed by controlling the frequency of the deformable mirror dynamic surface deformation. Currently, this FPGAbead SHWS design can achieve a 266 Hz cyclic speed limited by the camera frame rate as well as leaves 40% logic slices for additionally flexible design.

No scanning depth imaging system based on TOF

NASA Astrophysics Data System (ADS)

Sun, Rongchun; Piao, Yan; Wang, Yu; Liu, Shuo

2016-03-01

To quickly obtain a 3D model of real world objects, multi-point ranging is very important. However, the traditional measuring method usually adopts the principle of point by point or line by line measurement, which is too slow and of poor efficiency. In the paper, a no scanning depth imaging system based on TOF (time of flight) was proposed. The system is composed of light source circuit, special infrared image sensor module, processor and controller of image data, data cache circuit, communication circuit, and so on. According to the working principle of the TOF measurement, image sequence was collected by the high-speed CMOS sensor, and the distance information was obtained by identifying phase difference, and the amplitude image was also calculated. Experiments were conducted and the experimental results show that the depth imaging system can achieve no scanning depth imaging function with good performance.

High-speed upper-airway imaging using full-range optical coherence tomography

NASA Astrophysics Data System (ADS)

Jing, Joseph; Zhang, Jun; Loy, Anthony Chin; Wong, Brian J. F.; Chen, Zhongping

2012-11-01

Obstruction in the upper airway can often cause reductions in breathing or gas exchange efficiency and lead to rest disorders such as sleep apnea. Imaging diagnosis of the obstruction region has been accomplished using computed tomography (CT) and magnetic resonance imaging (MRI). However CT requires the use of ionizing radiation, and MRI typically requires sedation of the patient to prevent motion artifacts. Long-range optical coherence tomography (OCT) has the potential to provide high-speed three-dimensional tomographic images with high resolution and without the use of ionizing radiation. In this paper, we present work on the development of a long-range OCT endoscopic probe with 1.2 mm OD and 20 mm working distance used in conjunction with a modified Fourier domain swept source OCT system to acquire structural and anatomical datasets of the human airway. Imaging from the bottom of the larynx to the end of the nasal cavity is completed within 40 s.

Method of preliminary localization of the iris in biometric access control systems

NASA Astrophysics Data System (ADS)

Minacova, N.; Petrov, I.

2015-10-01

This paper presents a method of preliminary localization of the iris, based on the stable brightness features of the iris in images of the eye. In tests on images of eyes from publicly available databases method showed good accuracy and speed compared to existing methods preliminary localization.

Terahertz imaging with compressed sensing and phase retrieval.

PubMed

Chan, Wai Lam; Moravec, Matthew L; Baraniuk, Richard G; Mittleman, Daniel M

2008-05-01

We describe a novel, high-speed pulsed terahertz (THz) Fourier imaging system based on compressed sensing (CS), a new signal processing theory, which allows image reconstruction with fewer samples than traditionally required. Using CS, we successfully reconstruct a 64 x 64 image of an object with pixel size 1.4 mm using a randomly chosen subset of the 4096 pixels, which defines the image in the Fourier plane, and observe improved reconstruction quality when we apply phase correction. For our chosen image, only about 12% of the pixels are required for reassembling the image. In combination with phase retrieval, our system has the capability to reconstruct images with only a small subset of Fourier amplitude measurements and thus has potential application in THz imaging with cw sources.

Ultra-high-speed variable focus optics for novel applications in advanced imaging

NASA Astrophysics Data System (ADS)

Kang, S.; Dotsenko, E.; Amrhein, D.; Theriault, C.; Arnold, C. B.

2018-02-01

With the advancement of ultra-fast manufacturing technologies, high speed imaging with high 3D resolution has become increasingly important. Here we show the use of an ultra-high-speed variable focus optical element, the TAG Lens, to enable new ways to acquire 3D information from an object. The TAG Lens uses sound to adjust the index of refraction profile in a liquid and thereby can achieve focal scanning rates greater than 100 kHz. When combined with a high-speed pulsed LED and a high-speed camera, we can exploit this phenomenon to achieve high-resolution imaging through large depths. By combining the image acquisition with digital image processing, we can extract relevant parameters such as tilt and angle information from objects in the image. Due to the high speeds at which images can be collected and processed, we believe this technique can be used as an efficient method of industrial inspection and metrology for high throughput applications.

Performance modeling of terahertz (THz) and millimeter waves (mmW) pupil plane imaging

NASA Astrophysics Data System (ADS)

Mohammadian, Nafiseh; Furxhi, Orges; Zhang, Lei; Offermans, Peter; Ghazi, Galia; Driggers, Ronald

2018-05-01

Terahertz- (THz) and millimeter-wave sensors are becoming more important in industrial, security, medical, and defense applications. A major problem in these sensing areas is the resolution, sensitivity, and visual acuity of the imaging systems. There are different fundamental parameters in designing a system that have significant effects on the imaging performance. The performance of THz systems can be discussed in terms of two characteristics: sensitivity and spatial resolution. New approaches for design and manufacturing of THz imagers are a vital basis for developing future applications. Photonics solutions have been at the technological forefront in THz band applications. A single scan antenna does not provide reasonable resolution, sensitivity, and speed. An effective approach to imaging is placing a high-performance antenna in a two-dimensional antenna array to achieve higher radiation efficiency and higher resolution in the imaging systems. Here, we present the performance modeling of a pupil plane imaging system to find the resolution and sensitivity efficiency of the imaging system.

Research and implementation of simulation for TDICCD remote sensing in vibration of optical axis

NASA Astrophysics Data System (ADS)

Liu, Zhi-hong; Kang, Xiao-jun; Lin, Zhe; Song, Li

2013-12-01

During the exposure time, the charge transfer speed in the push-broom direction and the line-by-lines canning speed of the sensor are required to match each other strictly for a space-borne TDICCD push-broom camera. However, as attitude disturbance of satellite and vibration of camera are inevitable, it is impossible to eliminate the speed mismatch, which will make the signal of different targets overlay each other and result in a decline of image resolution. The effects of velocity mismatch will be visually observed and analyzed by simulating the degradation of image quality caused by the vibration of the optical axis, and it is significant for the evaluation of image quality and design of the image restoration algorithm. How to give a model in time domain and space domain during the imaging time is the problem needed to be solved firstly. As vibration information for simulation is usually given by a continuous curve, the pixels of original image matrix and sensor matrix are discrete, as a result, they cannot always match each other well. The effect of simulation will also be influenced by the discrete sampling in integration time. In conclusion, it is quite significant for improving simulation accuracy and efficiency to give an appropriate discrete modeling and simulation method. The paper analyses discretization schemes in time domain and space domain and presents a method to simulate the quality of image of the optical system in the vibration of the line of sight, which is based on the principle of TDICCD sensor. The gray value of pixels in sensor matrix is obtained by a weighted arithmetic, which solves the problem of pixels dismatch. The result which compared with the experiment of hardware test indicate that this simulation system performances well in accuracy and reliability.

High speed photoacoustic imaging with fast OPO laser at 1.7 μm (Conference Presentation)

NASA Astrophysics Data System (ADS)

Piao, Zhonglie; Teng, Ma; Li, Jiawen; Qu, Yueqiao; Yu, Mingyue; Shung, K. Kirk; Zhou, Qifa; Kim, Chang-Seok; Chen, Zhongping

2016-03-01

Acute cardiovascular events are mostly due to a blood clot or thrombus induced by the sudden rupture of vulnerable atherosclerotic plaques within coronary artery walls. Based on the high optical absorption contrast of the lipid rich plaques within the vessel wall, intravascular photoacoustic (IVPA) imaging at 1.7 μm spectral band has shown promising capabilities for detecting of lipid composition, but the translation of the technology for in vivo application is limited by the slow imaging speed. In this work, we will present a high speed integrated IVPA/US imaging system with a 500 Hz optical parametric oscillator laser at 1725 nm (5 nm linewidth). A miniature catheter with 1.0 mm outer diameter was designed with a polished 200 μm multimode fiber and an ultrasound transducer with 45 MHz center frequency. Two optical illumination methods by gradient-index (GRIN) lens and ball lens are introduced and compared for higher spatial resolution. At 1725 nm, atherosclerotic rabbit abdominal aorta was imaged at two frame per second, which is more than one order of magnitude faster than previous reported IVPA imaging. Furthermore, by wide tuning range of the laser wavelength from 1680 nm to 1770 nm, spectroscopic photoacoustic analysis of lipid-mimicking phantom and an human atherosclerotic artery was performed ex vivo.

High-sensitivity supercontinuum-based parallel line-field optical coherence tomography with 1 million A-lines/s (Conference Presentation)

NASA Astrophysics Data System (ADS)

Barrick, Jessica; Doblas, Ana; Sears, Patrick R.; Ostrowski, Lawrence E.; Oldenburg, Amy L.

2017-02-01

While traditional, flying-spot, spectral domain OCT systems can achieve MHz linerates, they are limited by the need for mechanical scanning to produce a B-mode image. Line-field OCT (LF OCT) removes the need for mechanical scanning by simultaneously recording all A-lines on a 2D CMOS sensor. Our LF OCT system operates at the highest A-line rate of any spectral domain (SD) LF OCT system reported to date (1,024,000 A-lines/s). This is comparable with the fastest flying-spot SDOCT system reported. Additionally, all OCT systems face a tradeoff between imaging speed and sensitivity. Long exposure times improve sensitivity but can lead to undesirable motion artifacts. LF OCT has the potential to relax this tradeoff between sensitivity and imaging speed because all A-lines are exposed during the entire frame acquisition time. However, this advantage has not yet been realized due to the loss of power-per-A-line by spreading the illumination light across all A-lines on the sample. Here we use a supercontinuum source to illuminate the sample with 500mW of light in the 605-950 nm wavelength band, effectively providing 480 µW of power-per-A-line, with axial and lateral resolutions of 1.8 µm and 14 µm, respectively. With this system we achieve the highest reported sensitivity (113 dB) of any LF OCT system. We then demonstrate the capability of this system by capturing the rapidly beating cilia of human bronchial-epithelial cells in vitro. The combination of high speed and high sensitivity offered by supercontinuum-based LF SD OCT offers new opportunities for studying cell and tissue dynamics.

Preliminary results for mask metrology using spatial heterodyne interferometry

NASA Astrophysics Data System (ADS)

Bingham, Philip R.; Tobin, Kenneth; Bennett, Marylyn H.; Marmillion, Pat

2003-12-01

Spatial heterodyne interferometry (SHI) is an imaging technique that captures both the phase and amplitude of a complex wavefront in a single high-speed image. This technology was developed at the Oak Ridge National Laboratory (ORNL) and is currently being implemented for semiconductor wafer inspection by nLine Corporation. As with any system that measures phase, metrology and inspection of surface structures is possible by capturing a wavefront reflected from the surface. The interpretation of surface structure heights for metrology applications can become very difficult with the many layers of various materials used on semiconductor wafers, so inspection (defect detection) has been the primary focus for semiconductor wafers. However, masks used for photolithography typically only contain a couple well-defined materials opening the doors to high-speed mask metrology in 3 dimensions in addition to inspection. Phase shift masks often contain structures etched out of the transparent substrate material for phase shifting. While these structures are difficult to inspect using only intensity, the phase and amplitude images captured with SHI can produce very good resolution of these structures. The phase images also provide depth information that is crucial for these phase shift regions. Preliminary testing has been performed to determine the feasibility of SHI for high-speed non-contact mask metrology using a prototype SHI system with 532 nm wavelength illumination named the Visible Alpha Tool (VAT). These results show that prototype SHI system is capable of performing critical dimension measurements on 400nm lines with a repeatability of 1.4nm and line height measurements with a repeatability of 0.26nm. Additionally initial imaging of an alternating aperture phase shift mask has shown the ability of SHI to discriminate between typical phase shift heights.

Production and Characterization of High Repetition Rate Terahertz Radiation in Femtosecond-Laser-Induced Air Plasma

DTIC Science & Technology

2009-03-01

nanometer, 50 femtosecond, 0.35 Watt, 40 KHz, pulsed Ti:Sapphire laser system was used as the source infrared beam. This beam was focused onto a...development of high speed THz imaging and spectroscopy systems. Until recently, the production and detection of coherent THz radiation has been both...exist a tabletop model that generates enough power at a high enough repetition rate to be feasible for most imaging or spectroscopy systems. The

Development of an add-on kit for scanning confocal microscopy (Conference Presentation)

NASA Astrophysics Data System (ADS)

Guo, Kaikai; Zheng, Guoan

2017-03-01

Scanning confocal microscopy is a standard choice for many fluorescence imaging applications in basic biomedical research. It is able to produce optically sectioned images and provide acquisition versatility to address many samples and application demands. However, scanning a focused point across the specimen limits the speed of image acquisition. As a result, scanning confocal microscope only works well with stationary samples. Researchers have performed parallel confocal scanning using digital-micromirror-device (DMD), which was used to project a scanning multi-point pattern across the sample. The DMD based parallel confocal systems increase the imaging speed while maintaining the optical sectioning ability. In this paper, we report the development of an add-on kit for high-speed and low-cost confocal microscopy. By adapting this add-on kit to an existing regular microscope, one can convert it into a confocal microscope without significant hardware modifications. Compared with current DMD-based implementations, the reported approach is able to recover multiple layers along the z axis simultaneously. It may find applications in wafer inspection and 3D metrology of semiconductor circuit. The dissemination of the proposed add-on kit under $1000 budget could also lead to new types of experimental designs for biological research labs, e.g., cytology analysis in cell culture experiments, genetic studies on multicellular organisms, pharmaceutical drug profiling, RNA interference studies, investigation of microbial communities in environmental systems, and etc.

Automatic parquet block sorting using real-time spectral classification

NASA Astrophysics Data System (ADS)

Astrom, Anders; Astrand, Erik; Johansson, Magnus

1999-03-01

This paper presents a real-time spectral classification system based on the PGP spectrograph and a smart image sensor. The PGP is a spectrograph which extracts the spectral information from a scene and projects the information on an image sensor, which is a method often referred to as Imaging Spectroscopy. The classification is based on linear models and categorizes a number of pixels along a line. Previous systems adopting this method have used standard sensors, which often resulted in poor performance. The new system, however, is based on a patented near-sensor classification method, which exploits analogue features on the smart image sensor. The method reduces the enormous amount of data to be processed at an early stage, thus making true real-time spectral classification possible. The system has been evaluated on hardwood parquet boards showing very good results. The color defects considered in the experiments were blue stain, white sapwood, yellow decay and red decay. In addition to these four defect classes, a reference class was used to indicate correct surface color. The system calculates a statistical measure for each parquet block, giving the pixel defect percentage. The patented method makes it possible to run at very high speeds with a high spectral discrimination ability. Using a powerful illuminator, the system can run with a line frequency exceeding 2000 line/s. This opens up the possibility to maintain high production speed and still measure with good resolution.

Accelerating non-contrast-enhanced MR angiography with inflow inversion recovery imaging by skipped phase encoding and edge deghosting (SPEED).

PubMed

Chang, Zheng; Xiang, Qing-San; Shen, Hao; Yin, Fang-Fang

2010-03-01

To accelerate non-contrast-enhanced MR angiography (MRA) with inflow inversion recovery (IFIR) with a fast imaging method, Skipped Phase Encoding and Edge Deghosting (SPEED). IFIR imaging uses a preparatory inversion pulse to reduce signals from static tissue, while leaving inflow arterial blood unaffected, resulting in sparse arterial vasculature on modest tissue background. By taking advantage of vascular sparsity, SPEED can be simplified with a single-layer model to achieve higher efficiency in both scan time reduction and image reconstruction. SPEED can also make use of information available in multiple coils for further acceleration. The techniques are demonstrated with a three-dimensional renal non-contrast-enhanced IFIR MRA study. Images are reconstructed by SPEED based on a single-layer model to achieve an undersampling factor of up to 2.5 using one skipped phase encoding direction. By making use of information available in multiple coils, SPEED can achieve an undersampling factor of up to 8.3 with four receiver coils. The reconstructed images generally have comparable quality as that of the reference images reconstructed from full k-space data. As demonstrated with a three-dimensional renal IFIR scan, SPEED based on a single-layer model is able to reduce scan time further and achieve higher computational efficiency than the original SPEED.

Interferometric imaging of nonlocal electromechanical power transduction in ferroelectric domains.

PubMed

Zheng, Lu; Dong, Hui; Wu, Xiaoyu; Huang, Yen-Lin; Wang, Wenbo; Wu, Weida; Wang, Zheng; Lai, Keji

2018-05-22

The electrical generation and detection of elastic waves are the foundation for acoustoelectronic and acoustooptic systems. For surface acoustic wave devices, microelectromechanical/nanoelectromechanical systems, and phononic crystals, tailoring the spatial variation of material properties such as piezoelectric and elastic tensors may bring significant improvements to the system performance. Due to the much slower speed of sound than speed of light in solids, it is desirable to study various electroacoustic behaviors at the mesoscopic length scale. In this work, we demonstrate the interferometric imaging of electromechanical power transduction in ferroelectric lithium niobate domain structures by microwave impedance microscopy. In sharp contrast to the traditional standing-wave patterns caused by the superposition of counterpropagating waves, the constructive and destructive fringes in microwave dissipation images exhibit an intriguing one-wavelength periodicity. We show that such unusual interference patterns, which are fundamentally different from the acoustic displacement fields, stem from the nonlocal interaction between electric fields and elastic waves. The results are corroborated by numerical simulations taking into account the sign reversal of piezoelectric tensor in oppositely polarized domains. Our work paves ways to probe nanoscale electroacoustic phenomena in complex structures by near-field electromagnetic imaging.

Ultrasonic Shear Wave Elasticity Imaging (SWEI) Sequencing and Data Processing Using a Verasonics Research Scanner

PubMed Central

Deng, Yufeng; Rouze, Ned C.; Palmeri, Mark L.; Nightingale, Kathryn R.

2017-01-01

Ultrasound elasticity imaging has been developed over the last decade to estimate tissue stiffness. Shear wave elasticity imaging (SWEI) quantifies tissue stiffness by measuring the speed of propagating shear waves following acoustic radiation force excitation. This work presents the sequencing and data processing protocols of SWEI using a Verasonics system. The selection of the sequence parameters in a Verasonics programming script is discussed in detail. The data processing pipeline to calculate group shear wave speed (SWS), including tissue motion estimation, data filtering, and SWS estimation is demonstrated. In addition, the procedures for calibration of beam position, scanner timing, and transducer face heating are provided to avoid SWS measurement bias and transducer damage. PMID:28092508

A simple way to higher speed atomic force microscopy by retrofitting with a novel high-speed flexure-guided scanner

NASA Astrophysics Data System (ADS)

Ouma Alunda, Bernard; Lee, Yong Joong; Park, Soyeun

2018-06-01

A typical line-scan rate for a commercial atomic force microscope (AFM) is about 1 Hz. At such a rate, more than four minutes of scanning time is required to obtain an image of 256 × 256 pixels. Despite control electronics of most commercial AFMs permit faster scan rates, default piezoelectric X–Y scanners limit the overall speed of the system. This is a direct consequence of manufacturers choosing a large scan range over the maximum operating speed for a X–Y scanner. Although some AFM manufacturers offer reduced-scan area scanners as an option, the speed improvement is not significant because such scanners do not have large enough reduction in the scan range and are mainly targeted to reducing the overall cost of the AFM systems. In this article, we present a simple parallel-kinematic substitute scanner for a commercial atomic force microscope to afford a higher scanning speed with no other hardware or software upgrade to the original system. Although the scan area reduction is unavoidable, our modified commercial XE-70 AFM from Park Systems has achieved a line scan rate of over 50 Hz, more than 10 times faster than the original, unmodified system. Our flexure-guided X–Y scanner can be a simple drop-in replacement option for enhancing the speed of various aging atomic force microscopes.

High resolution stationary digital breast tomosynthesis using distributed carbon nanotube x-ray source array.

PubMed

Qian, Xin; Tucker, Andrew; Gidcumb, Emily; Shan, Jing; Yang, Guang; Calderon-Colon, Xiomara; Sultana, Shabana; Lu, Jianping; Zhou, Otto; Spronk, Derrek; Sprenger, Frank; Zhang, Yiheng; Kennedy, Don; Farbizio, Tom; Jing, Zhenxue

2012-04-01

The purpose of this study is to investigate the feasibility of increasing the system spatial resolution and scanning speed of Hologic Selenia Dimensions digital breast tomosynthesis (DBT) scanner by replacing the rotating mammography x-ray tube with a specially designed carbon nanotube (CNT) x-ray source array, which generates all the projection images needed for tomosynthesis reconstruction by electronically activating individual x-ray sources without any mechanical motion. The stationary digital breast tomosynthesis (s-DBT) design aims to (i) increase the system spatial resolution by eliminating image blurring due to x-ray tube motion and (ii) reduce the scanning time. Low spatial resolution and long scanning time are the two main technical limitations of current DBT technology. A CNT x-ray source array was designed and evaluated against a set of targeted system performance parameters. Simulations were performed to determine the maximum anode heat load at the desired focal spot size and to design the electron focusing optics. Field emission current from CNT cathode was measured for an extended period of time to determine the stable life time of CNT cathode for an expected clinical operation scenario. The source array was manufactured, tested, and integrated with a Selenia scanner. An electronic control unit was developed to interface the source array with the detection system and to scan and regulate x-ray beams. The performance of the s-DBT system was evaluated using physical phantoms. The spatially distributed CNT x-ray source array comprised 31 individually addressable x-ray sources covering a 30 angular span with 1 pitch and an isotropic focal spot size of 0.6 mm at full width at half-maximum. Stable operation at 28 kV(peak) anode voltage and 38 mA tube current was demonstrated with extended lifetime and good source-to-source consistency. For the standard imaging protocol of 15 views over 14, 100 mAs dose, and 2 × 2 detector binning, the projection resolution along the scanning direction increased from 4.0 cycles/mm [at 10% modulation-transfer-function (MTF)] in DBT to 5.1 cycles/mm in s-DBT at magnification factor of 1.08. The improvement is more pronounced for faster scanning speeds, wider angular coverage, and smaller detector pixel sizes. The scanning speed depends on the detector, the number of views, and the imaging dose. With 240 ms detector readout time, the s-DBT system scanning time is 6.3 s for a 15-view, 100 mAs scan regardless of the angular coverage. The scanning speed can be reduced to less than 4 s when detectors become faster. Initial phantom studies showed good quality reconstructed images. A prototype s-DBT scanner has been developed and evaluated by retrofitting the Selenia rotating gantry DBT scanner with a spatially distributed CNT x-ray source array. Preliminary results show that it improves system spatial resolution substantially by eliminating image blur due to x-ray focal spot motion. The scanner speed of s-DBT system is independent of angular coverage and can be increased with faster detector without image degration. The accelerated lifetime measurement demonstrated the long term stability of CNT x-ray source array with typical clinical operation lifetime over 3 years.

Coincidence electron/ion imaging with a fast frame camera

NASA Astrophysics Data System (ADS)

Li, Wen; Lee, Suk Kyoung; Lin, Yun Fei; Lingenfelter, Steven; Winney, Alexander; Fan, Lin

2015-05-01

A new time- and position- sensitive particle detection system based on a fast frame CMOS camera is developed for coincidence electron/ion imaging. The system is composed of three major components: a conventional microchannel plate (MCP)/phosphor screen electron/ion imager, a fast frame CMOS camera and a high-speed digitizer. The system collects the positional information of ions/electrons from a fast frame camera through real-time centroiding while the arrival times are obtained from the timing signal of MCPs processed by a high-speed digitizer. Multi-hit capability is achieved by correlating the intensity of electron/ion spots on each camera frame with the peak heights on the corresponding time-of-flight spectrum. Efficient computer algorithms are developed to process camera frames and digitizer traces in real-time at 1 kHz laser repetition rate. We demonstrate the capability of this system by detecting a momentum-matched co-fragments pair (methyl and iodine cations) produced from strong field dissociative double ionization of methyl iodide. We further show that a time resolution of 30 ps can be achieved when measuring electron TOF spectrum and this enables the new system to achieve a good energy resolution along the TOF axis.

Feasibility of telemammography as biomedical application for breast imaging

NASA Astrophysics Data System (ADS)

Beckerman, Barbara G.; Batsell, Stephen G.; MacIntyre, Lawrence P.; Sarraf, Hamed S.; Gleason, Shaun S.; Schnall, Mitchell D.

1999-07-01

Mammographic screening is an important tool in the early detection of breast cancer. The migration of mammography from the current mode of x-ray mammography using a film screen image detector and display to a digital technology provides an opportunity to improve access and performance of breast cancer screening. The sheer size and volume of the typical screening exam, the need to have previous screening data readily available, and the need to view other breast imaging data together to provide a common consensus and to plan treatment, make telemammography an ideal application for breast imaging. For telemammography to be a viable option, it must overcome the technical challenges related to transmission, archiving, management, processing and retrieval of large data sets. Researchers from the University of Pennsylvania, the University of Chicago and Lockheed Martin Energy Systems/Oak Ridge National Laboratory have developed a framework for transmission of large-scale medical images over high-speed networks, leveraged existing high-speed networks between research and medical facilities; tested the feasibility of point-to-point transmission of mammographic images in a near-real time environment; evaluated network performance and transmission scenarios; and investigated the impact of image preprocessing on an experimental computer-aided diagnosis system. Results of the initial study are reported here.

Palmprint Based Verification System Using SURF Features

NASA Astrophysics Data System (ADS)

Srinivas, Badrinath G.; Gupta, Phalguni

This paper describes the design and development of a prototype of robust biometric system for verification. The system uses features extracted using Speeded Up Robust Features (SURF) operator of human hand. The hand image for features is acquired using a low cost scanner. The palmprint region extracted is robust to hand translation and rotation on the scanner. The system is tested on IITK database of 200 images and PolyU database of 7751 images. The system is found to be robust with respect to translation and rotation. It has FAR 0.02%, FRR 0.01% and accuracy of 99.98% and can be a suitable system for civilian applications and high-security environments.

Quantitative Image Analysis Techniques with High-Speed Schlieren Photography

NASA Technical Reports Server (NTRS)

Pollard, Victoria J.; Herron, Andrew J.

2017-01-01

Optical flow visualization techniques such as schlieren and shadowgraph photography are essential to understanding fluid flow when interpreting acquired wind tunnel test data. Output of the standard implementations of these visualization techniques in test facilities are often limited only to qualitative interpretation of the resulting images. Although various quantitative optical techniques have been developed, these techniques often require special equipment or are focused on obtaining very precise and accurate data about the visualized flow. These systems are not practical in small, production wind tunnel test facilities. However, high-speed photography capability has become a common upgrade to many test facilities in order to better capture images of unsteady flow phenomena such as oscillating shocks and flow separation. This paper describes novel techniques utilized by the authors to analyze captured high-speed schlieren and shadowgraph imagery from wind tunnel testing for quantification of observed unsteady flow frequency content. Such techniques have applications in parametric geometry studies and in small facilities where more specialized equipment may not be available.

Per-Pixel Coded Exposure for High-Speed and High-Resolution Imaging Using a Digital Micromirror Device Camera

PubMed Central

Feng, Wei; Zhang, Fumin; Qu, Xinghua; Zheng, Shiwei

2016-01-01

High-speed photography is an important tool for studying rapid physical phenomena. However, low-frame-rate CCD (charge coupled device) or CMOS (complementary metal oxide semiconductor) camera cannot effectively capture the rapid phenomena with high-speed and high-resolution. In this paper, we incorporate the hardware restrictions of existing image sensors, design the sampling functions, and implement a hardware prototype with a digital micromirror device (DMD) camera in which spatial and temporal information can be flexibly modulated. Combined with the optical model of DMD camera, we theoretically analyze the per-pixel coded exposure and propose a three-element median quicksort method to increase the temporal resolution of the imaging system. Theoretically, this approach can rapidly increase the temporal resolution several, or even hundreds, of times without increasing bandwidth requirements of the camera. We demonstrate the effectiveness of our method via extensive examples and achieve 100 fps (frames per second) gain in temporal resolution by using a 25 fps camera. PMID:26959023

Per-Pixel Coded Exposure for High-Speed and High-Resolution Imaging Using a Digital Micromirror Device Camera.

PubMed

Feng, Wei; Zhang, Fumin; Qu, Xinghua; Zheng, Shiwei

2016-03-04

High-speed photography is an important tool for studying rapid physical phenomena. However, low-frame-rate CCD (charge coupled device) or CMOS (complementary metal oxide semiconductor) camera cannot effectively capture the rapid phenomena with high-speed and high-resolution. In this paper, we incorporate the hardware restrictions of existing image sensors, design the sampling functions, and implement a hardware prototype with a digital micromirror device (DMD) camera in which spatial and temporal information can be flexibly modulated. Combined with the optical model of DMD camera, we theoretically analyze the per-pixel coded exposure and propose a three-element median quicksort method to increase the temporal resolution of the imaging system. Theoretically, this approach can rapidly increase the temporal resolution several, or even hundreds, of times without increasing bandwidth requirements of the camera. We demonstrate the effectiveness of our method via extensive examples and achieve 100 fps (frames per second) gain in temporal resolution by using a 25 fps camera.

Online evaluation of a commercial video image analysis system (Computer Vision System) to predict beef carcass red meat yield and for augmenting the assignment of USDA yield grades. United States Department of Agriculture.

PubMed

Cannell, R C; Belk, K E; Tatum, J D; Wise, J W; Chapman, P L; Scanga, J A; Smith, G C

2002-05-01

Objective quantification of differences in wholesale cut yields of beef carcasses at plant chain speeds is important for the application of value-based marketing. This study was conducted to evaluate the ability of a commercial video image analysis system, the Computer Vision System (CVS) to 1) predict commercially fabricated beef subprimal yield and 2) augment USDA yield grading, in order to improve accuracy of grade assessment. The CVS was evaluated as a fully installed production system, operating on a full-time basis at chain speeds. Steer and heifer carcasses (n = 296) were evaluated using CVS, as well as by USDA expert and online graders, before the fabrication of carcasses into industry-standard subprimal cuts. Expert yield grade (YG), online YG, CVS estimated carcass yield, and CVS measured ribeye area in conjunction with expert grader estimates of the remaining YG factors (adjusted fat thickness, percentage of kidney-pelvic-heart fat, hot carcass weight) accounted for 67, 39, 64, and 65% of the observed variation in fabricated yields of closely trimmed subprimals. The dual component CVS predicted wholesale cut yields more accurately than current online yield grading, and, in an augmentation system, CVS ribeye measurement replaced estimated ribeye area in determination of USDA yield grade, and the accuracy of cutability prediction was improved, under packing plant conditions and speeds, to a level close to that of expert graders applying grades at a comfortable rate of speed offline.

High frame-rate computational ghost imaging system using an optical fiber phased array and a low-pixel APD array.

PubMed

Liu, Chunbo; Chen, Jingqiu; Liu, Jiaxin; Han, Xiang'e

2018-04-16

To obtain a high imaging frame rate, a computational ghost imaging system scheme is proposed based on optical fiber phased array (OFPA). Through high-speed electro-optic modulators, the randomly modulated OFPA can provide much faster speckle projection, which can be precomputed according to the geometry of the fiber array and the known phases for modulation. Receiving the signal light with a low-pixel APD array can effectively decrease the requirement on sampling quantity and computation complexity owing to the reduced data dimensionality while avoiding the image aliasing due to the spatial periodicity of the speckles. The results of analysis and simulation show that the frame rate of the proposed imaging system can be significantly improved compared with traditional systems.

Quantitative approach for optimizing e-beam condition of photoresist inspection and measurement

NASA Astrophysics Data System (ADS)

Lin, Chia-Jen; Teng, Chia-Hao; Cheng, Po-Chung; Sato, Yoshishige; Huang, Shang-Chieh; Chen, Chu-En; Maruyama, Kotaro; Yamazaki, Yuichiro

2018-03-01

Severe process margin in advanced technology node of semiconductor device is controlled by e-beam metrology system and e-beam inspection system with scanning electron microscopy (SEM) image. By using SEM, larger area image with higher image quality is required to collect massive amount of data for metrology and to detect defect in a large area for inspection. Although photoresist is the one of the critical process in semiconductor device manufacturing, observing photoresist pattern by SEM image is crucial and troublesome especially in the case of large image. The charging effect by e-beam irradiation on photoresist pattern causes deterioration of image quality, and it affect CD variation on metrology system and causes difficulties to continue defect inspection in a long time for a large area. In this study, we established a quantitative approach for optimizing e-beam condition with "Die to Database" algorithm of NGR3500 on photoresist pattern to minimize charging effect. And we enhanced the performance of measurement and inspection on photoresist pattern by using optimized e-beam condition. NGR3500 is the geometry verification system based on "Die to Database" algorithm which compares SEM image with design data [1]. By comparing SEM image and design data, key performance indicator (KPI) of SEM image such as "Sharpness", "S/N", "Gray level variation in FOV", "Image shift" can be retrieved. These KPIs were analyzed with different e-beam conditions which consist of "Landing Energy", "Probe Current", "Scanning Speed" and "Scanning Method", and the best e-beam condition could be achieved with maximum image quality, maximum scanning speed and minimum image shift. On this quantitative approach of optimizing e-beam condition, we could observe dependency of SEM condition on photoresist charging. By using optimized e-beam condition, measurement could be continued on photoresist pattern over 24 hours stably. KPIs of SEM image proved image quality during measurement and inspection was stabled enough.

High-speed on-chip windowed centroiding using photodiode-based CMOS imager

NASA Technical Reports Server (NTRS)

Pain, Bedabrata (Inventor); Sun, Chao (Inventor); Yang, Guang (Inventor); Cunningham, Thomas J. (Inventor); Hancock, Bruce (Inventor)

2003-01-01

A centroid computation system is disclosed. The system has an imager array, a switching network, computation elements, and a divider circuit. The imager array has columns and rows of pixels. The switching network is adapted to receive pixel signals from the image array. The plurality of computation elements operates to compute inner products for at least x and y centroids. The plurality of computation elements has only passive elements to provide inner products of pixel signals the switching network. The divider circuit is adapted to receive the inner products and compute the x and y centroids.

High-speed on-chip windowed centroiding using photodiode-based CMOS imager

NASA Technical Reports Server (NTRS)

Pain, Bedabrata (Inventor); Sun, Chao (Inventor); Yang, Guang (Inventor); Cunningham, Thomas J. (Inventor); Hancock, Bruce (Inventor)

2004-01-01

A centroid computation system is disclosed. The system has an imager array, a switching network, computation elements, and a divider circuit. The imager array has columns and rows of pixels. The switching network is adapted to receive pixel signals from the image array. The plurality of computation elements operates to compute inner products for at least x and y centroids. The plurality of computation elements has only passive elements to provide inner products of pixel signals the switching network. The divider circuit is adapted to receive the inner products and compute the x and y centroids.

Massively parallel information processing systems for space applications

NASA Technical Reports Server (NTRS)

Schaefer, D. H.

1979-01-01

NASA is developing massively parallel systems for ultra high speed processing of digital image data collected by satellite borne instrumentation. Such systems contain thousands of processing elements. Work is underway on the design and fabrication of the 'Massively Parallel Processor', a ground computer containing 16,384 processing elements arranged in a 128 x 128 array. This computer uses existing technology. Advanced work includes the development of semiconductor chips containing thousands of feedthrough paths. Massively parallel image analog to digital conversion technology is also being developed. The goal is to provide compact computers suitable for real-time onboard processing of images.

Tunable electro-optic filter stack

DOEpatents

Fontecchio, Adam K.; Shriyan, Sameet K.; Bellingham, Alyssa

2017-09-05

A holographic polymer dispersed liquid crystal (HPDLC) tunable filter exhibits switching times of no more than 20 microseconds. The HPDLC tunable filter can be utilized in a variety of applications. An HPDLC tunable filter stack can be utilized in a hyperspectral imaging system capable of spectrally multiplexing hyperspectral imaging data acquired while the hyperspectral imaging system is airborne. HPDLC tunable filter stacks can be utilized in high speed switchable optical shielding systems, for example as a coating for a visor or an aircraft canopy. These HPDLC tunable filter stacks can be fabricated using a spin coating apparatus and associated fabrication methods.

An active-optics image-motion compensation technology application for high-speed searching and infrared detection system

NASA Astrophysics Data System (ADS)

Wu, Jianping; Lu, Fei; Zou, Kai; Yan, Hong; Wan, Min; Kuang, Yan; Zhou, Yanqing

2018-03-01

An ultra-high angular velocity and minor-caliber high-precision stably control technology application for active-optics image-motion compensation, is put forward innovatively in this paper. The image blur problem due to several 100°/s high-velocity relative motion between imaging system and target is theoretically analyzed. The velocity match model of detection system and active optics compensation system is built, and active optics image motion compensation platform experiment parameters are designed. Several 100°/s high-velocity high-precision control optics compensation technology is studied and implemented. The relative motion velocity is up to 250°/s, and image motion amplitude is more than 20 pixel. After the active optics compensation, motion blur is less than one pixel. The bottleneck technology of ultra-high angular velocity and long exposure time in searching and infrared detection system is successfully broke through.

The influence of underwater turbulence on optical phase measurements

NASA Astrophysics Data System (ADS)

Redding, Brandon; Davis, Allen; Kirkendall, Clay; Dandridge, Anthony

2016-05-01

Emerging underwater optical imaging and sensing applications rely on phase-sensitive detection to provide added functionality and improved sensitivity. However, underwater turbulence introduces spatio-temporal variations in the refractive index of water which can degrade the performance of these systems. Although the influence of turbulence on traditional, non-interferometric imaging has been investigated, its influence on the optical phase remains poorly understood. Nonetheless, a thorough understanding of the spatio-temporal dynamics of the optical phase of light passing through underwater turbulence are crucial to the design of phase-sensitive imaging and sensing systems. To address this concern, we combined underwater imaging with high speed holography to provide a calibrated characterization of the effects of turbulence on the optical phase. By measuring the modulation transfer function of an underwater imaging system, we were able to calibrate varying levels of optical turbulence intensity using the Simple Underwater Imaging Model (SUIM). We then used high speed holography to measure the temporal dynamics of the optical phase of light passing through varying levels of turbulence. Using this method, we measured the variance in the amplitude and phase of the beam, the temporal correlation of the optical phase, and recorded the turbulence induced phase noise as a function of frequency. By bench marking the effects of varying levels of turbulence on the optical phase, this work provides a basis to evaluate the real-world potential of emerging underwater interferometric sensing modalities.

Development of Real Time Ultrasonic Imaging

DTIC Science & Technology

1999-01-01

piezoelectric material known as poly vinyl difluoride ( PVDF ) which enables the conversion of mechanical energy to charge the CCD chip. The system...geometries such as curved (wing) surfaces. Other future applications might include heavy gauge welds in plate, corrosion in piping, welds in piping...Harrison, G. "A Novel High Speed, High Resolution Ultrasound Imaging System", QNDE Review of Progress In Quantitative NDE, Plenum Press, Volume 17B, pp

WE-AB-207A-09: Optimization of the Design of a Moving Blocker for Cone-Beam CT Scatter Correction: Experimental Evaluation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, X; Ouyang, L; Jia, X

Purpose: A moving blocker based strategy has shown promising results for scatter correction in cone-beam computed tomography (CBCT). Different geometry designs and moving speeds of the blocker affect its performance in image reconstruction accuracy. The goal of this work is to optimize the geometric design and moving speed of the moving blocker system through experimental evaluations. Methods: An Elekta Synergy XVI system and an anthropomorphic pelvis phantom CIRS 801-P were used for our experiment. A blocker consisting of lead strips was inserted between the x-ray source and the phantom moving back and forth along rotation axis to measure the scattermore » signal. Accoriding to our Monte Carlo simulation results, three blockers were used, which have the same lead strip width 3.2mm and different gap between neighboring lead strips, 3.2, 6.4 and 9.6mm. For each blocker, three moving speeds were evaluated, 10, 20 and 30 pixels per projection (on the detector plane). Scatter signal in the unblocked region was estimated by cubic B-spline based interpolation from the blocked region. CBCT image was reconstructed by a total variation (TV) based algebraic iterative reconstruction (ART) algorithm from the partially blocked projection data. Reconstruction accuracy in each condition is quantified as CT number error of region of interest (ROI) by comparing to a CBCT reconstructed image from analytically simulated unblocked and scatter free projection data. Results: Highest reconstruction accuracy is achieved when the blocker width is 3.2 mm, the gap between neighboring lead strips is 9.6 mm and the moving speed is 20 pixels per projection. RMSE of the CT number of ROIs can be reduced from 436 to 27. Conclusions: Image reconstruction accuracy is greatly affected by the geometry design of the blocker. The moving speed does not have a very strong effect on reconstruction result if it is over 20 pixels per projection.« less

Web conferencing systems: Skype and MSN in telepathology

PubMed Central

Klock, Clóvis; Gomes, Regina de Paula Xavier

2008-01-01

Virtual pathology is a very important tool that can be used in several ways, including interconsultations with specialists in many areas and for frozen sections. We considered in this work the use of Windows Live Messenger and Skype for image transmission. The conference was made through wide broad internet using Nikon E 200 microscope and Digital Samsung Colour SCC-131 camera. Internet speed for transmission varied from 400 Kb to 2.0 Mb. Both programs allow voice transmission concomitant to image, so the communication between the involved pathologists was possible using microphones and speakers. Alive image could be seen by the receptor pathologist who was able to ask for moving the field or increase/diminish the augmentation. No phone call or typing required. The programs MSN and Skype can be used in many ways and with different operational systems installed in the computer. The capture system is simple and relatively cheap, what proves the viability of the system to be used in developing countries and in cities where do not exist pathologists. With the improvement of software and the improvement of digital image quality, associated to the use of the high speed broad band Internet this will be able to become a new modality in surgical pathology. PMID:18673501

Web conferencing systems: Skype and MSN in telepathology.

PubMed

Klock, Clóvis; Gomes, Regina de Paula Xavier

2008-07-15

Virtual pathology is a very important tool that can be used in several ways, including interconsultations with specialists in many areas and for frozen sections. We considered in this work the use of Windows Live Messenger and Skype for image transmission. The conference was made through wide broad internet using Nikon E 200 microscope and Digital Samsung Colour SCC-131 camera. Internet speed for transmission varied from 400 Kb to 2.0 Mb. Both programs allow voice transmission concomitant to image, so the communication between the involved pathologists was possible using microphones and speakers. A live image could be seen by the receptor pathologist who was able to ask for moving the field or increase/diminish the augmentation. No phone call or typing required. The programs MSN and Skype can be used in many ways and with different operational systems installed in the computer. The capture system is simple and relatively cheap, what proves the viability of the system to be used in developing countries and in cities where do not exist pathologists. With the improvement of software and the improvement of digital image quality, associated to the use of the high speed broad band Internet this will be able to become a new modality in surgical pathology.

High-speed atomic force microscopy and peak force tapping control

NASA Astrophysics Data System (ADS)

Hu, Shuiqing; Mininni, Lars; Hu, Yan; Erina, Natalia; Kindt, Johannes; Su, Chanmin

2012-03-01

ITRS Roadmap requires defect size measurement below 10 nanometers and challenging classifications for both blank and patterned wafers and masks. Atomic force microscope (AFM) is capable of providing metrology measurement in 3D at sub-nanometer accuracy but has long suffered from drawbacks in throughput and limitation of slow topography imaging without chemical information. This presentation focus on two disruptive technology developments, namely high speed AFM and quantitative nanomechanical mapping, which enables high throughput measurement with capability of identifying components through concurrent physical property imaging. The high speed AFM technology has allowed the imaging speed increase by 10-100 times without loss of the data quality. Such improvement enables the speed of defect review on a wafer to increase from a few defects per hour to nearly 100 defects an hour, approaching the requirements of ITRS Roadmap. Another technology development, Peak Force Tapping, substantially simplified the close loop system response, leading to self-optimization of most challenging samples groups to generate expert quality data. More importantly, AFM also simultaneously provides a series of mechanical property maps with a nanometer spatial resolution during defect review. These nanomechanical maps (including elastic modulus, hardness, and surface adhesion) provide complementary information for elemental analysis, differentiate defect materials by their physical properties, and assist defect classification beyond topographic measurements. This paper will explain the key enabling technologies, namely high speed tip-scanning AFM using innovative flexure design and control algorithm. Another critical element is AFM control using Peak Force Tapping, in which the instantaneous tip-sample interaction force is measured and used to derive a full suite of physical properties at each imaging pixel. We will provide examples of defect review data on different wafers and media disks. The similar AFM-based defect review capacity was also applied to EUV masks.

Gigantic Cosmic Corkscrew Reveals New Details About Mysterious Microquasar

NASA Astrophysics Data System (ADS)

2004-10-01

Making an extra effort to image a faint, gigantic corkscrew traced by fast protons and electrons shot out from a mysterious microquasar paid off for a pair of astrophysicists who gained new insights into the beast's inner workings and also resolved a longstanding dispute over the object's distance. Microquasar SS 433 VLA Image of Microquasar SS 433 CREDIT: Blundell & Bowler, NRAO/AUI/NSF (Click on Image for Larger Version) The astrophysicists used the National Science Foundation's Very Large Array (VLA) radio telescope to capture the faintest details yet seen in the plasma jets emerging from the microquasar SS 433, an object once dubbed the "enigma of the century." As a result, they have changed scientists' understanding of the jets and settled the controversy over its distance "beyond all reasonable doubt," they said. SS 433 is a neutron star or black hole orbited by a "normal" companion star. The powerful gravity of the neutron star or black hole draws material from the stellar wind of its companion into an accretion disk of material tightly circling the dense central object prior to being pulled onto it. This disk propels jets of fast protons and electrons outward from its poles at about a quarter of the speed of light. The disk in SS 433 wobbles like a child's top, causing its jets to trace a corkscrew in the sky every 162 days. The new VLA study indicates that the speed of the ejected particles varies over time, contrary to the traditional model for SS 433. "We found that the actual speed varies between 24 percent to 28 percent of light speed, as opposed to staying constant," said Katherine Blundell, of the University of Oxford in the United Kingdom. "Amazingly, the jets going in both directions change their speeds simultaneously, producing identical speeds in both directions at any given time," Blundell added. Blundell worked with Michael Bowler, also of Oxford. The scientists' findings have been accepted by the Astrophysical Journal Letters. SS 433 New VLA Image of SS 433: Red-and-Blue Line Shows Path of Constant-Speed Jets. Note Poor Match of Path to Image. CREDIT: Blundell & Bowler, NRAO/AUI/NSF SS 433 Same Image, With Colored Beads Representing Particle Ejections at Different Speeds. Particle Path Now Matches. CREDIT: Blundell & Bowler, NRAO/AUI/NSF Click Here for Page of Full-Sized Graphics The new VLA image shows two full turns of the jets' corkscrew on both sides of the core. Analyzing the image showed that if material came from the core at a constant speed, the jet paths would not accurately match the details of the image. "By simulating ejections at varying speeds, we were able to produce an exact match to the observed structure," Blundell explained. The scientists first did their match to one of the jets. "We then were stunned to see that the varying speeds that matched the structure of one jet also exactly reproduced the other jet's path," Blundell said. Matching the speeds in the two jets reproduced the observed structure even allowing for the fact that, because one jet is moving more nearly away from us than the other, it takes light longer to reach us from it, she added. The astrophysicists speculate that the changes in ejection speed may be caused by changes in the rate at which material is transferred from the companion star onto the accretion disk. The detailed new VLA image also allowed the astrophysicists to determine that SS 433 is nearly 18,000 light-years distant from Earth. Earlier estimates had the object, in the constellation Aquila, as near as 10,000 light-years. An accurate distance, the scientists said, now allows them to better determine the age of the shell of debris blown out by the supernova explosion that created the dense, compact object in the microquasar. Knowing the distance accurately also allows them to measure the actual brightness of the microquasar's components, and this, they said, improves their understanding of the physical processes at work in the system. The breakthrough image was made using 10 hours of observing time with the VLA in a configuration that maximizes the VLA's ability to see fine detail. It represents the longest "time exposure" of SS 433 at radio wavelengths, and thus shows the faintest details. It also represents the best such image that can be done with current technology. Because the jets in SS 433 are moving, their image would be "smeared" in a longer observation. In order to see even fainter details in the jets, the astrophysicists must await the greater sensitivity of the Expanded VLA, set to become available in a few years. SS 433 was the first example of what now are termed microquasars, binary systems with either a neutron star or black hole orbited by another star, and emitting jets of material at high speeds. The strange stellar system received a wealth of media coverage in the late 1970s and early 1980s. A 1981 Sky & Telescope article was entitled, "SS 433 -- Enigma of the Century." Because microquasars in our own Milky Way Galaxy are thought to produce their high-speed jets of material through processes similar to those that produce jets from the cores of galaxies, the nearby microquasars serve as a convenient "laboratory" for studying the physics of jets. The microquasars are closer and show changes more quickly than their larger cousins. Katherine Blundell is a University Research Fellow funded by the UK's Royal Society. The National Radio Astronomy Observatory is a facility of the National Science Foundation, operated under cooperative agreement by Associated Universities, Inc.

Performance evaluation of stereo endoscopic imaging system incorporating TFT-LCD.

PubMed

Song, C-G; Park, S-K

2005-01-01

This paper presents a 3D endoscopic video system designed to improve visualization and enhance the ability of the surgeon to perform delicate endoscopic surgery. In a comparison of the polarized and electric shutter-type stereo imaging systems, the former was found to be superior in terms of both accuracy and speed for knot-tying and for the loop pass test. The results of our experiments show that the proposed 3D endoscopic system has a sufficiently wide viewing angle and zone for multi-viewing, and that it provides better image quality and more stable optical performance compared with the electric shutter-type.

High-speed spectral infrared imaging of spark ignition engine combustion. (Reannouncement with new availability information)

DOE Office of Scientific and Technical Information (OSTI.GOV)

McComiskey, T.; Jiang, H.; Qian, Y.

1993-03-05

In-cylinder flame propagation and its impact on thermal characteristics of the combustion chamber were studied by using a new high-speed spectral infrared imaging system. In this work, successive spectral IR images of combustion chamber events were captured while varying several parameters, including fuel/air, spark timing, speed, and warming-up period. Some investigation of cyclic variation, knock, and high-temperature components during the non-combustion period was also conducted. It was found that the spectral images obtained in both short and long wavelength bands exhibited unique pieces of in-cylinder information, i.e., (qualitative) distributions of temperature and combustion products, respectively. During the combustion period, themore » temperature of early-formed combustion products continued to increase while the flame front temperature, e.g. near the end gas zone, remained relatively low. The exhaust valve emitted strong radiation starting from the early stage of the combustion period. The spark plug emitted the strongest radiation during the non-combustion period. Considerable cyclic variation in growth of the flame front and completion of the reaction was observable. The radiation from both spectral bands became stronger as the engine warm-up period in While operating the engine with the addition of n-heptane in the intake to produce knock, we captured spectral IR images of the end gas right before it was abruptly consumed. The combustion products that were formed in the end-gas volume upon knock, showed no evidence of higher temperature than other zones in the combustion chamber.... Spectral infrared imaging, High-speed, Digital data, Instantaneous distribution, Spark ignition combustion.« less

A high-speed pnCCD detector system for optical applications

NASA Astrophysics Data System (ADS)

Hartmann, R.; Buttler, W.; Gorke, H.; Herrmann, S.; Holl, P.; Meidinger, N.; Soltau, H.; Strüder, L.

2006-11-01

Measurements of a frame-store pnCCD detector system, optimized for high-speed applications in the optical and near infrared (NIR) region, will be presented. The device with an image area of 13.5 mm by 13.5 mm and a pixelsize of 51 μm by 51 μm exhibits a readout time faster than 1100 frames per second with an overall electronic noise contribution of less than three electrons. Variable operation modes of the detector system allow for even higher readout speeds by a pixel binning in transfer direction or, at slightly slower readout speeds, a further improvement in noise performance. We will also present the concept of a data acquisition system being able to handle pixel rates of more than 75 megapixel per second. The application of an anti-reflective coating on the ultra-thin entrance window of the back illuminated detector together with the large sensitive volume ensures a high and uniform detection efficiency from the ultra violet to the NIR.

TRIIG - Time-lapse reproduction of images through interactive graphics. [digital processing of quality hard copy

NASA Technical Reports Server (NTRS)

Buckner, J. D.; Council, H. W.; Edwards, T. R.

1974-01-01

Description of the hardware and software implementing the system of time-lapse reproduction of images through interactive graphics (TRIIG). The system produces a quality hard copy of processed images in a fast and inexpensive manner. This capability allows for optimal development of processing software through the rapid viewing of many image frames in an interactive mode. Three critical optical devices are used to reproduce an image: an Optronics photo reader/writer, the Adage Graphics Terminal, and Polaroid Type 57 high speed film. Typical sources of digitized images are observation satellites, such as ERTS or Mariner, computer coupled electron microscopes for high-magnification studies, or computer coupled X-ray devices for medical research.

A fast and high-sensitive dual-wavelength diffuse optical tomography system using digital lock-in photon-counting technique

NASA Astrophysics Data System (ADS)

Chen, Weiting; Yi, Xi; Zhao, Huijuan; Gao, Feng

2014-09-01

We presented a novel dual-wavelength diffuse optical imaging system which can perform 2-D or 3-D imaging fast and high-sensitively for monitoring the dynamic change of optical parameters. A newly proposed lock-in photon-counting detection method was adopted for week optical signal collection, which brought in excellent property as well as simplified geometry. Fundamental principles of the lock-in photon-counting detection were elaborately demonstrated, and the feasibility was strictly verified by the linearity experiment. Systemic performance of the prototype set up was experimentally accessed, including stray light rejection and inherent interference. Results showed that the system possessed superior anti-interference capability (under 0.58% in darkroom) compared with traditional photon-counting detection, and the crosstalk between two wavelengths was lower than 2.28%. For comprehensive assessment, 2-D phantom experiments towards relatively large dimension model (diameter of 4cm) were conducted. Different absorption targets were imaged to investigate detection sensitivity. Reconstruction image under all conditions was exciting, with a desirable SNR. Study on image quality v.s. integration time put forward a new method for accessing higher SNR with the sacrifice of measuring speed. In summary, the newly developed system showed great potential in promoting detection sensitivity as well as measuring speed. This will make substantial progress in dynamically tracking the blood concentration distribution in many clinical areas, such as small animal disease modeling, human brain activity research and thick tissues (for example, breast) diagnosis.

Background-Oriented Schlieren used in a hypersonic inlet test at NASA GRC

NASA Technical Reports Server (NTRS)

Clem, Michelle; Woike, Mark; Saunders, John

2016-01-01

Background Oriented Schlieren (BOS) is a derivative of the classical schlieren technology, which is used to visualize density gradients, such as shock wave structures in a wind tunnel. Changes in refractive index resulting from density gradients cause light rays to bend, resulting in apparent motion of a random background pattern. The apparent motion of the pattern is determined using cross-correlation algorithms (between no-flow and with-flow image pairs) producing a schlieren-like image. One advantage of BOS is its simplified setup which enables a larger field-of-view (FOV) than traditional schlieren systems. In the present study, BOS was implemented into the Combined Cycle Engine Large-Scale Inlet Mode Transition Experiment (CCE LIMX) in the 10x10 Supersonic Wind Tunnel at NASA Glenn Research Center. The model hardware for the CCE LIMX accommodates a fully integrated turbine based combined cycle propulsion system. To date, inlet mode transition between turbine and ramjet operation has been successfully demonstrated. High-speed BOS was used to visualize the behavior of the flow structures shock waves during unsteady inlet unstarts, a phenomenon known as buzz. Transient video images of inlet buzz were recorded for both the ramjet flow path (high speed inlet) and turbine flow path (low speed inlet). To understand the stability limits of the inlet, operation was pushed to the point of unstart and buzz. BOS was implemented in order to view both inlets simultaneously, since the required FOV was beyond the capability of the current traditional schlieren system. An example of BOS data (Images 1-6) capturing inlet buzz are presented.

High-brightness laser imaging with tunable speckle reduction enabled by electroactive micro-optic diffusers.

PubMed

Farrokhi, Hamid; Rohith, Thazhe Madam; Boonruangkan, Jeeranan; Han, Seunghwoi; Kim, Hyunwoong; Kim, Seung-Woo; Kim, Young-Jin

2017-11-10

High coherence of lasers is desirable in high-speed, high-resolution, and wide-field imaging. However, it also causes unavoidable background speckle noise thus degrades the image quality in traditional microscopy and more significantly in interferometric quantitative phase imaging (QPI). QPI utilizes optical interference for high-precision measurement of the optical properties where the speckle can severely distort the information. To overcome this, we demonstrated a light source system having a wide tunability in the spatial coherence over 43% by controlling the illumination angle, scatterer's size, and the rotational speed of an electroactive-polymer rotational micro-optic diffuser. Spatially random phase modulation was implemented for the lower speckle imaging with over a 50% speckle reduction without a significant degradation in the temporal coherence. Our coherence control technique will provide a unique solution for a low-speckle, full-field, and coherent imaging in optically scattering media in the fields of healthcare sciences, material sciences and high-precision engineering.

A high speed multifocal multiphoton fluorescence lifetime imaging microscope for live-cell FRET imaging

PubMed Central

Poland, Simon P.; Krstajić, Nikola; Monypenny, James; Coelho, Simao; Tyndall, David; Walker, Richard J.; Devauges, Viviane; Richardson, Justin; Dutton, Neale; Barber, Paul; Li, David Day-Uei; Suhling, Klaus; Ng, Tony; Henderson, Robert K.; Ameer-Beg, Simon M.

2015-01-01

We demonstrate diffraction limited multiphoton imaging in a massively parallel, fully addressable time-resolved multi-beam multiphoton microscope capable of producing fluorescence lifetime images with sub-50ps temporal resolution. This imaging platform offers a significant improvement in acquisition speed over single-beam laser scanning FLIM by a factor of 64 without compromising in either the temporal or spatial resolutions of the system. We demonstrate FLIM acquisition at 500 ms with live cells expressing green fluorescent protein. The applicability of the technique to imaging protein-protein interactions in live cells is exemplified by observation of time-dependent FRET between the epidermal growth factor receptor (EGFR) and the adapter protein Grb2 following stimulation with the receptor ligand. Furthermore, ligand-dependent association of HER2-HER3 receptor tyrosine kinases was observed on a similar timescale and involved the internalisation and accumulation or receptor heterodimers within endosomes. These data demonstrate the broad applicability of this novel FLIM technique to the spatio-temporal dynamics of protein-protein interaction. PMID:25780724

TIME-SEQUENCED X-RAY OBSERVATION OF A THERMAL EXPLOSION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tringe, J. W.; Molitoris, J. D.; Kercher, J. R.

The evolution of a thermally-initiated explosion is studied using a multiple-image x-ray system. HMX-based PBX 9501 is used in this work, enabling direct comparison to recently-published data obtained with proton radiography [1]. Multiple x-ray images of the explosion are obtained with image spacing of ten microseconds or more. The explosion is simultaneously characterized with a high-speed camera using an interframe spacing of 11 mus. X-ray and camera images were both initiated passively by signals from an embedded thermocouple array, as opposed to being actively triggered by a laser pulse or other external source. X-ray images show an accelerating reacting frontmore » within the explosive, and also show unreacted explosive at the time the containment vessel bursts. High-speed camera images show debris ejected from the vessel expanding at 800-2100 m/s in the first tens of mus after the container wall failure. The effective center of the initiation volume is about 6 mm from the geometric center of the explosive.« less

High-speed adaptive contact-mode atomic force microscopy imaging with near-minimum-force

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ren, Juan; Zou, Qingze, E-mail: qzzou@rci.rutgers.edu

In this paper, an adaptive contact-mode imaging approach is proposed to replace the traditional contact-mode imaging by addressing the major concerns in both the speed and the force exerted to the sample. The speed of the traditional contact-mode imaging is largely limited by the need to maintain precision tracking of the sample topography over the entire imaged sample surface, while large image distortion and excessive probe-sample interaction force occur during high-speed imaging. In this work, first, the image distortion caused by the topography tracking error is accounted for in the topography quantification. Second, the quantified sample topography is utilized inmore » a gradient-based optimization method to adjust the cantilever deflection set-point for each scanline closely around the minimal level needed for maintaining stable probe-sample contact, and a data-driven iterative feedforward control that utilizes a prediction of the next-line topography is integrated to the topography feeedback loop to enhance the sample topography tracking. The proposed approach is demonstrated and evaluated through imaging a calibration sample of square pitches at both high speeds (e.g., scan rate of 75 Hz and 130 Hz) and large sizes (e.g., scan size of 30 μm and 80 μm). The experimental results show that compared to the traditional constant-force contact-mode imaging, the imaging speed can be increased by over 30 folds (with the scanning speed at 13 mm/s), and the probe-sample interaction force can be reduced by more than 15% while maintaining the same image quality.« less

High-speed adaptive contact-mode atomic force microscopy imaging with near-minimum-force.

PubMed

Ren, Juan; Zou, Qingze

2014-07-01

In this paper, an adaptive contact-mode imaging approach is proposed to replace the traditional contact-mode imaging by addressing the major concerns in both the speed and the force exerted to the sample. The speed of the traditional contact-mode imaging is largely limited by the need to maintain precision tracking of the sample topography over the entire imaged sample surface, while large image distortion and excessive probe-sample interaction force occur during high-speed imaging. In this work, first, the image distortion caused by the topography tracking error is accounted for in the topography quantification. Second, the quantified sample topography is utilized in a gradient-based optimization method to adjust the cantilever deflection set-point for each scanline closely around the minimal level needed for maintaining stable probe-sample contact, and a data-driven iterative feedforward control that utilizes a prediction of the next-line topography is integrated to the topography feeedback loop to enhance the sample topography tracking. The proposed approach is demonstrated and evaluated through imaging a calibration sample of square pitches at both high speeds (e.g., scan rate of 75 Hz and 130 Hz) and large sizes (e.g., scan size of 30 μm and 80 μm). The experimental results show that compared to the traditional constant-force contact-mode imaging, the imaging speed can be increased by over 30 folds (with the scanning speed at 13 mm/s), and the probe-sample interaction force can be reduced by more than 15% while maintaining the same image quality.

Design and Development of a High Speed Sorting System Based on Machine Vision Guiding

NASA Astrophysics Data System (ADS)

Zhang, Wenchang; Mei, Jiangping; Ding, Yabin

In this paper, a vision-based control strategy to perform high speed pick-and-place tasks on automation product line is proposed, and relevant control software is develop. Using Delta robot to control a sucker to grasp disordered objects from one moving conveyer and then place them on the other in order. CCD camera gets one picture every time the conveyer moves a distance of ds. Objects position and shape are got after image processing. Target tracking method based on "Servo motor + synchronous conveyer" is used to fulfill the high speed porting operation real time. Experiments conducted on Delta robot sorting system demonstrate the efficiency and validity of the proposed vision-control strategy.

Earth elevation map production and high resolution sensing camera imaging analysis

NASA Astrophysics Data System (ADS)

Yang, Xiubin; Jin, Guang; Jiang, Li; Dai, Lu; Xu, Kai

2010-11-01

The Earth's digital elevation which impacts space camera imaging has prepared and imaging has analysed. Based on matching error that TDI CCD integral series request of the speed of image motion, statistical experimental methods-Monte Carlo method is used to calculate the distribution histogram of Earth's elevation in image motion compensated model which includes satellite attitude changes, orbital angular rate changes, latitude, longitude and the orbital inclination changes. And then, elevation information of the earth's surface from SRTM is read. Earth elevation map which produced for aerospace electronic cameras is compressed and spliced. It can get elevation data from flash according to the shooting point of latitude and longitude. If elevation data between two data, the ways of searching data uses linear interpolation. Linear interpolation can better meet the rugged mountains and hills changing requests. At last, the deviant framework and camera controller are used to test the character of deviant angle errors, TDI CCD camera simulation system with the material point corresponding to imaging point model is used to analyze the imaging's MTF and mutual correlation similarity measure, simulation system use adding cumulation which TDI CCD imaging exceeded the corresponding pixel horizontal and vertical offset to simulate camera imaging when stability of satellite attitude changes. This process is practicality. It can effectively control the camera memory space, and meet a very good precision TDI CCD camera in the request matches the speed of image motion and imaging.

Ultrafast fingerprint indexing for embedded systems

NASA Astrophysics Data System (ADS)

Zhou, Ru; Sin, Sang Woo; Li, Dongju; Isshiki, Tsuyoshi; Kunieda, Hiroaki

2011-10-01

A novel core-based fingerprint indexing scheme for embedded systems is presented in this paper. Our approach is enabled by our new precise and fast core-detection algorithm with the direction map. It introduces the feature of CMP (core minutiae pair), which describes the coordinates of minutiae and the direction of ridges associated with the minutiae based on the uniquely defined core coordinates. Since each CMP is identical against the shift and rotation of the fingerprint image, the CMP comparison between a template and an input image can be performed without any alignment. The proposed indexing algorithm based on CMP is suitable for embedded systems because the tremendous speed up and the memory reduction are achieved. In fact, the experiments with the fingerprint database FVC2002 show that its speed for the identifications becomes about 40 times faster than conventional approaches, even though the database includes fingerprints with no core.

High speed, wide velocity dynamic range Doppler optical coherence tomography (Part III): in vivo endoscopic imaging of blood flow in the rat and human gastrointestinal tracts

NASA Astrophysics Data System (ADS)

Yang, Victor X. D.; Gordon, Maggie L.; Tang, Shou-Jiang; Marcon, Norman E.; Gardiner, Geoffrey; Qi, Bing; Bisland, Stuart; Seng-Yue, Emily; Lo, Stewart; Pekar, Julius; Wilson, Brian C.; Vitkin, I. Alex

2003-09-01

We previously described a fiber based Doppler optical coherence tomography system [1] capable of imaging embryo cardiac blood flow at 4~16 frames per second with wide velocity dynamic range [2]. Coupling this system to a linear scanning fiber optical catheter design that minimizes friction and vibrations, we report here the initial results of in vivo endoscopic Doppler optical coherence tomography (EDOCT) imaging in normal rat and human esophagus. Microvascular flow in blood vessels less than 100 µm diameter was detected using a combination of color-Doppler and velocity variance imaging modes, during clinical endoscopy using a mobile EDOCT system.

On-line 3-dimensional confocal imaging in vivo.

PubMed

Li, J; Jester, J V; Cavanagh, H D; Black, T D; Petroll, W M

2000-09-01

In vivo confocal microscopy through focusing (CMTF) can provide a 3-D stack of high-resolution corneal images and allows objective measurements of corneal sublayer thickness and backscattering. However, current systems require time-consuming off-line image processing and analysis on multiple software platforms. Furthermore, there is a trade off between the CMTF speed and measurement precision. The purpose of this study was to develop a novel on-line system for in vivo corneal imaging and analysis that overcomes these limitations. A tandem scanning confocal microscope (TSCM) was used for corneal imaging. The TSCM video camera was interfaced directly to a PC image acquisition board to implement real-time digitization. Software was developed to allow in vivo 2-D imaging, CMTF image acquisition, interactive 3-D reconstruction, and analysis of CMTF data to be performed on line in a single user-friendly environment. A procedure was also incorporated to separate the odd/even video fields, thereby doubling the CMTF sampling rate and theoretically improving the precision of CMTF thickness measurements by a factor of two. In vivo corneal examinations of a normal human and a photorefractive keratectomy patient are presented to demonstrate the capabilities of the new system. Improvements in the convenience, speed, and functionality of in vivo CMTF image acquisition, display, and analysis are demonstrated. This is the first full-featured software package designed for in vivo TSCM imaging of the cornea, which performs both 2-D and 3-D image acquisition, display, and processing as well as CMTF analysis. The use of a PC platform and incorporation of easy to use, on line, and interactive features should help to improve the clinical utility of this technology.

Low-speed flowfield characterization by infrared measurements of surface temperatures

NASA Technical Reports Server (NTRS)

Gartenberg, E.; Roberts, A. S., Jr.; Mcree, G. J.

1989-01-01

An experimental program was aimed at identifying areas in low speed aerodynamic research where infrared imaging systems can make significant contributions. Implementing a new technique, a long electrically heated wire was placed across a laminar jet. By measuring the temperature distribution along the wire with the IR imaging camera, the flow behavior was identified. Furthermore, using Nusselt number correlations, the velocity distribution could be deduced. The same approach was used to survey wakes behind cylinders in a wind-tunnel. This method is suited to investigate flows with position dependent velocities, e.g., boundary layers, confined flows, jets, wakes, and shear layers. It was found that the IR imaging camera cannot accurately track high gradient temperature fields. A correlation procedure was devised to account for this limitation. Other wind-tunnel experiments included tracking the development of the laminar boundary layer over a warmed flat plate by measuring the chordwise temperature distribution. This technique was applied also to the flow downstream from a rearward facing step. Finally, the IR imaging system was used to study boundary layer behavior over an airfoil at angles of attack from zero up to separation. The results were confirmed with tufts observable both visually and with the IR imaging camera.

Measuring contraction propagation and localizing pacemaker cells using high speed video microscopy

PubMed Central

Akl, Tony J.; Nepiyushchikh, Zhanna V.; Gashev, Anatoliy A.; Zawieja, David C.; Coté, Gerard L.

2011-01-01

Previous studies have shown the ability of many lymphatic vessels to contract phasically to pump lymph. Every lymphangion can act like a heart with pacemaker sites that initiate the phasic contractions. The contractile wave propagates along the vessel to synchronize the contraction. However, determining the location of the pacemaker sites within these vessels has proven to be very difficult. A high speed video microscopy system with an automated algorithm to detect pacemaker location and calculate the propagation velocity, speed, duration, and frequency of the contractions is presented in this paper. Previous methods for determining the contractile wave propagation velocity manually were time consuming and subject to errors and potential bias. The presented algorithm is semiautomated giving objective results based on predefined criteria with the option of user intervention. The system was first tested on simulation images and then on images acquired from isolated microlymphatic mesenteric vessels. We recorded contraction propagation velocities around 10 mm∕s with a shortening speed of 20.4 to 27.1 μm∕s on average and a contraction frequency of 7.4 to 21.6 contractions∕min. The simulation results showed that the algorithm has no systematic error when compared to manual tracking. The system was used to determine the pacemaker location with a precision of 28 μm when using a frame rate of 300 frames per second. PMID:21361700

Vehicle and cargo container inspection system for drugs

NASA Astrophysics Data System (ADS)

Verbinski, Victor V.; Orphan, Victor J.

1999-06-01

A vehicle and cargo container inspection system has been developed which uses gamma-ray radiography to produce digital images useful for detection of drugs and other contraband. The system is comprised of a 1 Ci Cs137 gamma-ray source collimated into a fan beam which is aligned with a linear array of NaI gamma-ray detectors located on the opposite side of the container. The NaI detectors are operated in the pulse-counting mode. A digital image of the vehicle or container is obtained by moving the aligned source and detector array relative to the object. Systems have been demonstrated in which the object is stationary (source and detector array move on parallel tracks) and in which the object moves past a stationary source and detector array. Scanning speeds of ˜30 cm/s with a pixel size (at the object) of ˜1 cm have been achieved. Faster scanning speeds of ˜2 m/s have been demonstrated on railcars with more modest spatial resolution (4 cm pixels). Digital radiographic images are generated from the detector count rates. These images, recorded on a PC-based data acquisition and display system, are shown from several applications: 1) inspection of trucks and containers at a border crossing, 2) inspection of railcars at a border crossing, 3) inspection of outbound cargo containers for stolen automobiles, and 4) inspection of trucks and cars for terrorist bombs.

An in situ optical imaging system for measuring lipid uptake, vessel contraction, and lymph flow in small animal lymphatic vessels

NASA Astrophysics Data System (ADS)

Kassis, Timothy; Weiler, Michael J.; Dixon, J. Brandon

2012-03-01

All dietary lipids are transported to venous circulation through the lymphatic system, yet the underlying mechanisms that regulate this process remain unclear. Understanding how the lymphatics functionally respond to changes in lipid load is important in the diagnosis and treatment of lipid and lymphatic related diseases such as obesity, hypercholesterolemia, and lymphedema. Therefore, we sought to develop an in situ imaging system to quantify and correlate lymphatic function as it relates to lipid transport. A custom-built optical set-up provides us with the capability of dual-channel imaging of both high-speed bright-field video and fluorescence simultaneously. This is achieved by dividing the light path into two optical bands. Utilizing high-speed and back-illuminated CCD cameras and post-acquisition image processing algorithms, we have the potential quantify correlations between vessel contraction, lymph flow and lipid concentration of mesenteric lymphatic vessels in situ. Local flow velocity is measured through lymphocyte tracking, vessel contraction through measurements of the vessel walls and lipid uptake through fluorescence intensity tracking of a fluorescent long chain fatty acid analogue, Bodipy FL C16. This system will prove to be an invaluable tool for both scientists studying lymphatic function in health and disease, and those investigating strategies for targeting the lymphatic system with orally delivered drugs.

North by Northwestern: initial experience with PACS at Northwestern Memorial Hospital

NASA Astrophysics Data System (ADS)

Channin, David S.; Hawkins, Rodney C.; Enzmann, Dieter R.

2000-05-01

This paper describes the initial phases and configuration of the Picture Archive and Communication System (PACS) deployed at Northwestern Memorial Hospital. The primary goals of the project were to improve service to patients, improve service to referring physicians, and improve the process of radiology. Secondary goals were to enhance the academic mission, and modernize institutional information systems. The system consists of a large number of heterogeneous imaging modalities sending imaging studies via DICOM to a GE medical Systems PathSpeed PACS. The radiology department workflow is briefly described. The system is currently storing approximately 140,000 studies and over 5 million images, growing by approximately 600 studies and 25,000 images per day. Data reflecting use of the short term and long term storage is provided.

Shear wave speed recovery in transient elastography and supersonic imaging using propagating fronts

NASA Astrophysics Data System (ADS)

McLaughlin, Joyce; Renzi, Daniel

2006-04-01

Transient elastography and supersonic imaging are promising new techniques for characterizing the elasticity of soft tissues. Using this method, an 'ultrafast imaging' system (up to 10 000 frames s-1) follows in real time the propagation of a low frequency shear wave. The displacement of the propagating shear wave is measured as a function of time and space. The objective of this paper is to develop and test algorithms whose ultimate product is images of the shear wave speed of tissue mimicking phantoms. The data used in the algorithms are the front of the propagating shear wave. Here, we first develop techniques to find the arrival time surface given the displacement data from a transient elastography experiment. The arrival time surface satisfies the Eikonal equation. We then propose a family of methods, called distance methods, to solve the inverse Eikonal equation: given the arrival times of a propagating wave, find the wave speed. Lastly, we explain why simple inversion schemes for the inverse Eikonal equation lead to large outliers in the wave speed and numerically demonstrate that the new scheme presented here does not have any large outliers. We exhibit two recoveries using these methods: one is with synthetic data; the other is with laboratory data obtained by Mathias Fink's group (the Laboratoire Ondes et Acoustique, ESPCI, Université Paris VII).

High-repetition-rate interferometric Rayleigh scattering for flow-velocity measurements

NASA Astrophysics Data System (ADS)

Estevadeordal, Jordi; Jiang, Naibo; Cutler, Andrew D.; Felver, Josef J.; Slipchenko, Mikhail N.; Danehy, Paul M.; Gord, James R.; Roy, Sukesh

2018-03-01

High-repetition-rate interferometric-Rayleigh-scattering (IRS) velocimetry is demonstrated for non-intrusive, high-speed flow-velocity measurements. High temporal resolution is obtained with a quasi-continuous burst-mode laser that is capable of operating at 10-100 kHz, providing 10-ms bursts with pulse widths of 5-1000 ns and pulse energy > 100 mJ at 532 nm. Coupled with a high-speed camera system, the IRS method is based on imaging the flow field through an etalon with 8-GHz free spectral range and capturing the Doppler shift of the Rayleigh-scattered light from the flow at multiple points having constructive interference. The seed-laser linewidth permits a laser linewidth of < 150 MHz at 532 nm. The technique is demonstrated in a high-speed jet, and high-repetition-rate image sequences are shown.

High speed automated microtomography of nuclear emulsions and recent application

NASA Astrophysics Data System (ADS)

Tioukov, V.; Aleksandrov, A.; Consiglio, L.; De Lellis, G.; Vladymyrov, M.

2015-12-01

The development of high-speed automatic scanning systems was the key-factor for massive and successful emulsions application for big neutrino experiments like OPERA. The emulsion detector simplicity, the unprecedented sub-micron spatial resolution and the unique ability to provide intrinsically 3-dimensional spatial information make it a perfect device for short-living particles study, where the event topology should be precisely reconstructed in a 10-100 um scale vertex region. Recently the exceptional technological progress in image processing and automation together with intensive R&D done by Italian and Japanese microscopy groups permit to increase the scanning speed to unbelievable few years ago m2/day scale and so greatly extend the range of the possible applications for emulsion-based detectors to other fields like: medical imaging, directional dark matter search, nuclear physics, geological and industrial applications.

Three-Dimensional ISAR Imaging Method for High-Speed Targets in Short-Range Using Impulse Radar Based on SIMO Array.

PubMed

Zhou, Xinpeng; Wei, Guohua; Wu, Siliang; Wang, Dawei

2016-03-11

This paper proposes a three-dimensional inverse synthetic aperture radar (ISAR) imaging method for high-speed targets in short-range using an impulse radar. According to the requirements for high-speed target measurement in short-range, this paper establishes the single-input multiple-output (SIMO) antenna array, and further proposes a missile motion parameter estimation method based on impulse radar. By analyzing the motion geometry relationship of the warhead scattering center after translational compensation, this paper derives the receiving antenna position and the time delay after translational compensation, and thus overcomes the shortcomings of conventional translational compensation methods. By analyzing the motion characteristics of the missile, this paper estimates the missile's rotation angle and the rotation matrix by establishing a new coordinate system. Simulation results validate the performance of the proposed algorithm.

[Quantitative image of bone mineral content--dual energy subtraction in a single exposure].

PubMed

Katoh, T

1990-09-25

A dual energy subtraction system was constructed on an experimental basis for the quantitative image of bone mineral content. The system consists of a radiography system and an image processor. Two radiograms were taken with dual x-ray energy in a single exposure using an x-ray beam dichromized by a tin filter. In this system, a film cassette was used where a low speed film-screen system, a copper filter and a high speed film-screen system were layered on top of each other. The images were read by a microdensitometer and processed by a personal computer. The image processing included the corrections of the film characteristics and heterogeneity in the x-ray field, and the dual energy subtraction in which the effect of the high energy component of the dichromized beam on the tube side image was corrected. In order to determine the accuracy of the system, experiments using wedge phantoms made of mixtures of epoxy resin and bone mineral-equivalent materials in various fractions were performed for various tube potentials and film processing conditions. The results indicated that the relative precision of the system was within +/- 4% and that the propagation of the film noise was within +/- 11 mg/cm2 for the 0.2 mm pixels. The results also indicated that the system response was independent of the tube potential and the film processing condition. The bone mineral weight in each phalanx of the freshly dissected hand of a rhesus monkey was measured by this system and compared with the ash weight. The results showed an error of +/- 10%, slightly larger than that of phantom experiments, which is probably due to the effect of fat and the variation of focus-object distance. The air kerma in free air at the object was approximately 0.5 mGy for one exposure. The results indicate that this system is applicable to clinical use and provides useful information for evaluating a time-course of localized bone disease.

The use of high-speed imaging in education

NASA Astrophysics Data System (ADS)

Kleine, H.; McNamara, G.; Rayner, J.

2017-02-01

Recent improvements in camera technology and the associated improved access to high-speed camera equipment have made it possible to use high-speed imaging not only in a research environment but also specifically for educational purposes. This includes high-speed sequences that are created both with and for a target audience of students in high schools and universities. The primary goal is to engage students in scientific exploration by providing them with a tool that allows them to see and measure otherwise inaccessible phenomena. High-speed imaging has the potential to stimulate students' curiosity as the results are often surprising or may contradict initial assumptions. "Live" demonstrations in class or student- run experiments are highly suitable to have a profound influence on student learning. Another aspect is the production of high-speed images for demonstration purposes. While some of the approaches known from the application of high speed imaging in a research environment can simply be transferred, additional techniques must often be developed to make the results more easily accessible for the targeted audience. This paper describes a range of student-centered activities that can be undertaken which demonstrate how student engagement and learning can be enhanced through the use of high speed imaging using readily available technologies.

AO corrected satellite imaging from Mount Stromlo

NASA Astrophysics Data System (ADS)

Bennet, F.; Rigaut, F.; Price, I.; Herrald, N.; Ritchie, I.; Smith, C.

2016-07-01

The Research School of Astronomy and Astrophysics have been developing adaptive optics systems for space situational awareness. As part of this program we have developed satellite imaging using compact adaptive optics systems for small (1-2 m) telescopes such as those operated by Electro Optic Systems (EOS) from the Mount Stromlo Observatory. We have focused on making compact, simple, and high performance AO systems using modern high stroke high speed deformable mirrors and EMCCD cameras. We are able to track satellites down to magnitude 10 with a Strehl in excess of 20% in median seeing.

Fully integrated high-speed intravascular optical coherence tomography/near-infrared fluorescence structural/molecular imaging in vivo using a clinically available near-infrared fluorescence-emitting indocyanine green to detect inflamed lipid-rich atheromata in coronary-sized vessels.

PubMed

Lee, Sunki; Lee, Min Woo; Cho, Han Saem; Song, Joon Woo; Nam, Hyeong Soo; Oh, Dong Joo; Park, Kyeongsoon; Oh, Wang-Yuhl; Yoo, Hongki; Kim, Jin Won

2014-08-01

Lipid-rich inflamed coronary plaques are prone to rupture. The purpose of this study was to assess lipid-rich inflamed plaques in vivo using fully integrated high-speed optical coherence tomography (OCT)/near-infrared fluorescence (NIRF) molecular imaging with a Food and Drug Administration-approved indocyanine green (ICG). An integrated high-speed intravascular OCT/NIRF imaging catheter and a dual-modal OCT/NIRF system were constructed based on a clinical OCT platform. For imaging lipid-rich inflamed plaques, the Food and Drug Administration-approved NIRF-emitting ICG (2.25 mg/kg) or saline was injected intravenously into rabbit models with experimental atheromata induced by balloon injury and 12- to 14-week high-cholesterol diets. Twenty minutes after injection, in vivo OCT/NIRF imaging of the infrarenal aorta and iliac arteries was acquired only under contrast flushing through catheter (pullback speed up to ≤20 mm/s). NIRF signals were strongly detected in the OCT-visualized atheromata of the ICG-injected rabbits. The in vivo NIRF target-to-background ratio was significantly larger in the ICG-injected rabbits than in the saline-injected controls (P<0.01). Ex vivo peak plaque target-to-background ratios were significantly higher in ICG-injected rabbits than in controls (P<0.01) on fluorescence reflectance imaging, which correlated well with the in vivo target-to-background ratios (P<0.01; r=0.85) without significant bias (0.41). Cellular ICG uptake, correlative fluorescence microscopy, and histopathology also corroborated the in vivo imaging findings. Integrated OCT/NIRF structural/molecular imaging with a Food and Drug Administration -approved ICG accurately identified lipid-rich inflamed atheromata in coronary-sized vessels. This highly translatable dual-modal imaging approach could enhance our capabilities to detect high-risk coronary plaques. © 2014 American Heart Association, Inc.

High-Speed Laser Image Analysis of Plume Angles for Pressurised Metered Dose Inhalers: The Effect of Nozzle Geometry.

PubMed

Chen, Yang; Young, Paul M; Murphy, Seamus; Fletcher, David F; Long, Edward; Lewis, David; Church, Tanya; Traini, Daniela

2017-04-01

The aim of this study is to investigate aerosol plume geometries of pressurised metered dose inhalers (pMDIs) using a high-speed laser image system with different actuator nozzle materials and designs. Actuators made from aluminium, PET and PTFE were manufactured with four different nozzle designs: cone, flat, curved cone and curved flat. Plume angles and spans generated using the designed actuator nozzles with four solution-based pMDI formulations were imaged using Oxford Lasers EnVision system and analysed using EnVision Patternate software. Reduced plume angles for all actuator materials and nozzle designs were observed with pMDI formulations containing drug with high co-solvent concentration (ethanol) due to the reduced vapour pressure. Significantly higher plume angles were observed with the PTFE flat nozzle across all formulations, which could be a result of the nozzle geometry and material's hydrophobicity. The plume geometry of pMDI aerosols can be influenced by the vapour pressure of the formulation, nozzle geometries and actuator material physiochemical properties.

Prediction of pork loin quality using online computer vision system and artificial intelligence model.

PubMed

Sun, Xin; Young, Jennifer; Liu, Jeng-Hung; Newman, David

2018-06-01

The objective of this project was to develop a computer vision system (CVS) for objective measurement of pork loin under industry speed requirement. Color images of pork loin samples were acquired using a CVS. Subjective color and marbling scores were determined according to the National Pork Board standards by a trained evaluator. Instrument color measurement and crude fat percentage were used as control measurements. Image features (18 color features; 1 marbling feature; 88 texture features) were extracted from whole pork loin color images. Artificial intelligence prediction model (support vector machine) was established for pork color and marbling quality grades. The results showed that CVS with support vector machine modeling reached the highest prediction accuracy of 92.5% for measured pork color score and 75.0% for measured pork marbling score. This research shows that the proposed artificial intelligence prediction model with CVS can provide an effective tool for predicting color and marbling in the pork industry at online speeds. Copyright © 2018 Elsevier Ltd. All rights reserved.

Feature Detection of Curve Traffic Sign Image on The Bandung - Jakarta Highway

NASA Astrophysics Data System (ADS)

Naseer, M.; Supriadi, I.; Supangkat, S. H.

2018-03-01

Unsealed roadside and problems with the road surface are common causes of road crashes, particularly when those are combined with curves. Curve traffic sign is an important component for giving early warning to driver on traffic, especially on high-speed traffic like on the highway. Traffic sign detection has became a very interesting research now, and in this paper will be discussed about the detection of curve traffic sign. There are two types of curve signs are discussed, namely the curve turn to the left and the curve turn to the right and the all data sample used are the curves taken / recorded from some signs on the Bandung - Jakarta Highway. Feature detection of the curve signs use Speed Up Robust Feature (SURF) method, where the detected scene image is 800x450. From 45 curve turn to the right images, the system can detect the feature well to 35 images, where the success rate is 77,78%, while from the 45 curve turn to the left images, the system can detect the feature well to 34 images and the success rate is 75,56%, so the average accuracy in the detection process is 76,67%. While the average time for the detection process is 0.411 seconds.

Blood vessel rupture by cavitation

PubMed Central

Chen, Hong; Brayman, Andrew A.; Bailey, Michael R.

2011-01-01

Cavitation is thought to be one mechanism for vessel rupture during shock wave lithotripsy treatment. However, just how cavitation induces vessel rupture remains unknown. In this work, a high-speed photomicrography system was set up to directly observe the dynamics of bubbles inside blood vessels in ex vivo rat mesenteries. Vascular rupture correlating to observed bubble dynamics were examined by imaging bubble extravasation and dye leakage. The high-speed images show that bubble expansion can cause vessel distention, and bubble collapse can lead to vessel invagination. Liquid jets were also observed to form. Our results suggest that all three mechanisms, vessel distention, invagination and liquid jets, can contribute to vessel rupture. PMID:20680255

A fast two-plus-one phase-shifting algorithm for high-speed three-dimensional shape measurement system

NASA Astrophysics Data System (ADS)

Wang, Wenyun; Guo, Yingfu

2008-12-01

Phase-shifting methods for 3-D shape measurement have long been employed in optical metrology for their speed and accuracy. For real-time, accurate, 3-D shape measurement, a four-step phase-shifting algorithm which has the advantage of its symmetry is a good choice; however, its measurement error is sensitive to any fringe image errors caused by various sources such as motion blur. To alleviate this problem, a fast two-plus-one phase-shifting algorithm is proposed in this paper. This kind of technology will benefit many applications such as medical imaging, gaming, animation, computer vision, computer graphics, etc.

True logarithmic amplification of frequency clock in SS-OCT for calibration

PubMed Central

Liu, Bin; Azimi, Ehsan; Brezinski, Mark E.

2011-01-01

With swept source optical coherence tomography (SS-OCT), imprecise signal calibration prevents optimal imaging of biological tissues such as coronary artery. This work demonstrates an approach using a true logarithmic amplifier to precondition the clock signal, with the effort to minimize the noises and phase errors for optimal calibration. This method was validated and tested with a high-speed SS-OCT. The experimental results manifest its superior ability on optimization of the calibration and improvement of the imaging performance. Particularly, this hardware-based approach is suitable for real-time calibration in a high-speed system where computation time is constrained. PMID:21698036

Poster — Thur Eve — 56: Design of Quality Assurance Methodology for VMAT system on Agility System equipped with CVDR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thind, K; Tolakanahalli, R

2014-08-15

The aim of this study was to analyze the feasibility of designing comprehensive QA plans using iComCAT for Elekta machines equipped with Agility multileaf collimator and continuously variable dose rate. Test plans with varying MLC speed, gantry speed, and dose rate were created and delivered in a controlled manner. A strip test was designed with three 1 cm MLC positions and delivered using dynamic, StepNShoot and VMAT techniques. Plans were also designed to test error in MLC position with various gantry speeds and various MLC speeds. The delivery fluence was captured using the electronic portal-imaging device. Gantry speed was foundmore » to be within tolerance as per the Canadian standards. MLC positioning errors at higher MLC speed with gravity effects does add more than 2 mm discrepancy. More tests need to be performed to evaluate MLC performance using independent measurement systems. The treatment planning system with end-to-end testing necessary for commissioning was also investigated and found to have >95% passing rates within 3%/3mm gamma criteria. Future studies involve performing off-axis gantry starshot pattern and repeating the tests on three matched Elekta linear accelerators.« less

The aero optics effect on near space laser communication optical system

NASA Astrophysics Data System (ADS)

Hu, Yuan; Fu, Yuegang; Jiang, Huilin

2013-08-01

With the developing of the space laser communication link, the performance index including higher transfer speed, extending transfer distance, and environmental adaptability, all ask the system accuracy and indexes improving. Special the developing near space platform, its environmental is extremes, the near space drone and other airplane flight speed is very quickly from the subsonic to supersonic. The aero optics effect caused by high speed will generate a thin turbulent air layer. It affects the performance of laser communication optical system by laser light vibration, deviation and so on, further more affects the performance of laser communication system working performance, even can't communication. Therefore, for achieving optical system indexes, we need do more research in optical system near space aero optics environmental adaptability. In this paper, near space link environmental characteristic are researched. And on the base of the aero optics theory, computer simulating method is applied to analyze the relationship among the altitude, the flight speed and the image dispersion. The result shows that, the aero optics effect cannot be ignored when the terminal is in low altitude or is moving with supersonic speed. The effect must be taken into considered from overall design. The result will provide the basis of research design.

Imaging of sound speed using reflection ultrasound tomography.

PubMed

Nebeker, Jakob; Nelson, Thomas R

2012-09-01

The goal of this work was to obtain and evaluate measurements of tissue sound speed in the breast, particularly dense breasts, using backscatter ultrasound tomography. An automated volumetric breast ultrasound scanner was constructed for imaging the prone patient. A 5- to 7-MHz linear array transducer acquired 17,920 radiofrequency pulse echo A-lines from the breast, and a back-wall reflector rotated over 360° in 25 seconds. Sound speed images used reflector echoes that after preprocessing were uploaded into a graphics processing unit for filtered back-projection reconstruction. A velocimeter also was constructed to measure the sound speed and attenuation for comparison to scanner performance. Measurements were made using the following: (1) deionized water from 22°C to 90°C; (2) various fluids with sound speeds from 1240 to 1904 m/s; (3) acrylamide gel test objects with features from 1 to 15 mm in diameter; and (4) healthy volunteers. The mean error ± SD between sound speed reference and image data was -0.48% ± 9.1%, and the error between reference and velocimeter measurements was -1.78% ± 6.50%. Sound speed image and velocimeter measurements showed a difference of 0.10% ± 4.04%. Temperature data showed a difference between theory and imaging performance of -0.28% ± 0.22%. Images of polyacrylamide test objects showed detectability of an approximately 1% sound speed difference in a 2.4-mm cylindrical inclusion with a contrast to noise ratio of 7.9 dB. An automated breast scanner offers the potential to make consistent automated tomographic images of breast backscatter, sound speed, and attenuation, potentially improving diagnosis, particularly in dense breasts.

Active hyperspectral imaging using a quantum cascade laser (QCL) array and digital-pixel focal plane array (DFPA) camera.

PubMed

Goyal, Anish; Myers, Travis; Wang, Christine A; Kelly, Michael; Tyrrell, Brian; Gokden, B; Sanchez, Antonio; Turner, George; Capasso, Federico

2014-06-16

We demonstrate active hyperspectral imaging using a quantum-cascade laser (QCL) array as the illumination source and a digital-pixel focal-plane-array (DFPA) camera as the receiver. The multi-wavelength QCL array used in this work comprises 15 individually addressable QCLs in which the beams from all lasers are spatially overlapped using wavelength beam combining (WBC). The DFPA camera was configured to integrate the laser light reflected from the sample and to perform on-chip subtraction of the passive thermal background. A 27-frame hyperspectral image was acquired of a liquid contaminant on a diffuse gold surface at a range of 5 meters. The measured spectral reflectance closely matches the calculated reflectance. Furthermore, the high-speed capabilities of the system were demonstrated by capturing differential reflectance images of sand and KClO₃ particles that were moving at speeds of up to 10 m/s.

Simultaneous high-speed schlieren and OH chemiluminescence imaging in a hybrid rocket combustor at elevated pressures

NASA Astrophysics Data System (ADS)

Miller, Victor; Jens, Elizabeth T.; Mechentel, Flora S.; Cantwell, Brian J.; Stanford Propulsion; Space Exploration Group Team

2014-11-01

In this work, we present observations of the overall features and dynamics of flow and combustion in a slab-type hybrid rocket combustor. Tests were conducted in the recently upgraded Stanford Combustion Visualization Facility, a hybrid rocket combustor test platform capable of generating constant mass-flux flows of oxygen. High-speed (3 kHz) schlieren and OH chemiluminescence imaging were used to visualize the flow. We present imaging results for the combustion of two different fuel grains, a classic, low regression rate polymethyl methacrylate (PMMA), and a high regression rate paraffin, and all tests were conducted in gaseous oxygen. Each fuel grain was tested at multiple free-stream pressures at constant oxidizer mass flux (40 kg/m2s). The resulting image sequences suggest that aspects of the dynamics and scaling of the system depend strongly on both pressure and type of fuel.

Two-dimensional real-time imaging system for subtraction angiography using an iodine filter

NASA Astrophysics Data System (ADS)

Umetani, Keiji; Ueda, Ken; Takeda, Tohoru; Anno, Izumi; Itai, Yuji; Akisada, Masayoshi; Nakajima, Teiichi

1992-01-01

A new type of subtraction imaging system was developed using an iodine filter and a single-energy broad bandwidth monochromatized x ray. The x-ray images of coronary arteries made after intravenous injection of a contrast agent are enhanced by an energy-subtraction technique. Filter chopping of the x-ray beam switches energies rapidly, so that a nearly simultaneous pair of filtered and nonfiltered images can be made. By using a high-speed video camera, a pair of two 512 × 512 pixel images can be obtained within 9 ms. Three hundred eighty-four images (raw data) are stored in a 144-Mbyte frame memory. After phantom studies, in vivo subtracted images of coronary arteries in dogs were obtained at a rate of 15 images/s.

A head movement image (HMI)-controlled computer mouse for people with disabilities.

PubMed

Chen, Yu-Luen; Chen, Weoi-Luen; Kuo, Te-Son; Lai, Jin-Shin

2003-02-04

This study proposes image processing and microprocessor technology for use in developing a head movement image (HMI)-controlled computer mouse system for the spinal cord injured (SCI). The system controls the movement and direction of the mouse cursor by capturing head movement images using a marker installed on the user's headset. In the clinical trial, this new mouse system was compared with an infrared-controlled mouse system on various tasks with nine subjects with SCI. The results were favourable to the new mouse system. The differences between the new mouse system and the infrared-controlled mouse were reaching statistical significance in each of the test situations (p<0.05). The HMI-controlled computer mouse improves the input speed. People with disabilities need only wear the headset and move their heads to freely control the movement of the mouse cursor.

Improving arrival time identification in transient elastography

NASA Astrophysics Data System (ADS)

Klein, Jens; McLaughlin, Joyce; Renzi, Daniel

2012-04-01

In this paper, we improve the first step in the arrival time algorithm used for shear wave speed recovery in transient elastography. In transient elastography, a shear wave is initiated at the boundary and the interior displacement of the propagating shear wave is imaged with an ultrasound ultra-fast imaging system. The first step in the arrival time algorithm finds the arrival times of the shear wave by cross correlating displacement time traces (the time history of the displacement at a single point) with a reference time trace located near the shear wave source. The second step finds the shear wave speed from the arrival times. In performing the first step, we observe that the wave pulse decorrelates as it travels through the medium, which leads to inaccurate estimates of the arrival times and ultimately to blurring and artifacts in the shear wave speed image. In particular, wave ‘spreading’ accounts for much of this decorrelation. Here we remove most of the decorrelation by allowing the reference wave pulse to spread during the cross correlation. This dramatically improves the images obtained from arrival time identification. We illustrate the improvement of this method on phantom and in vivo data obtained from the laboratory of Mathias Fink at ESPCI, Paris.

PROGRAM ASPECT - FOR REMOTE SENSING OF AIRBORNE PLUMES

EPA Science Inventory

The SAFEGUARD program is a multi-sensor program for the detection and imaging of chemical plumes and vapors. The system is composed of an airborne sensor suite including an infrared line scanner and a high-speed fourier transform infrared spectrometer. Both systems are integrat...

High-speed and high-SNR photoacoustic microscopy based on a galvanometer mirror in non-conducting liquid

PubMed Central

Kim, Jin Young; Lee, Changho; Park, Kyungjin; Han, Sangyeob; Kim, Chulhong

2016-01-01

Optical-resolution photoacoustic microscopy (OR-PAM), a promising microscopic imaging technique with high ultrasound resolution and superior optical sensitivity, can provide anatomical, functional, and molecular information at scales ranging from the microvasculature to single red blood cells. In particular, real-time OR-PAM imaging with a high signal-to-noise ratio (SNR) is a prerequisite for widespread use in preclinical and clinical applications. Although several technical approaches have been pursued to simultaneously improve the imaging speed and SNR of OR-PAM, they are bulky, complex, not sensitive, and/or not actually real-time. In this paper, we demonstrate a simple and novel OR-PAM technique which is based on a typical galvanometer immersed in non-conducting liquid. Using an opto-ultrasound combiner, this OR-PAM system achieves a high SNR and fast imaging speed. It takes only 2 seconds to acquire a volumetric image with a wide field of view (FOV) of 4 × 8 mm2 along the X and Y axes, respectively. The measured lateral and axial resolutions are 6.0 and 37.7 μm, respectively. Finally, as a demonstration of the system’s capability, we successfully imaged the microvasculature in a mouse ear in vivo. Our new method will contribute substantially to the popularization and commercialization of OR-PAM in various preclinical and clinical applications. PMID:27708379

Implementation of total focusing method for phased array ultrasonic imaging on FPGA

NASA Astrophysics Data System (ADS)

Guo, JianQiang; Li, Xi; Gao, Xiaorong; Wang, Zeyong; Zhao, Quanke

2015-02-01

This paper describes a multi-FPGA imaging system dedicated for the real-time imaging using the Total Focusing Method (TFM) and Full Matrix Capture (FMC). The system was entirely described using Verilog HDL language and implemented on Altera Stratix IV GX FPGA development board. The whole algorithm process is to: establish a coordinate system of image and divide it into grids; calculate the complete acoustic distance of array element between transmitting array element and receiving array element, and transform it into index value; then index the sound pressure values from ROM and superimpose sound pressure values to get pixel value of one focus point; and calculate the pixel values of all focus points to get the final imaging. The imaging result shows that this algorithm has high SNR of defect imaging. And FPGA with parallel processing capability can provide high speed performance, so this system can provide the imaging interface, with complete function and good performance.

Biocentrifuge system capable of exchanging specimen cages while in operational mode

NASA Technical Reports Server (NTRS)

Belew, R. R. (Inventor)

1981-01-01

The centrifuge comprises a generally circular, rotatably mounted frame carrying a plurality of removable and replaceable cages for the animal specimens. Pairs of opposing cages may be removed from the frame while it is rotating by means of a cage exchanger which rotates concentrically within the centrifuge and the speed of which is controlled independently of the frame speed. An image rotator is provided for selective observation of the rotating animals. The system further includes a waste conveyor system, a food supply system, and a water supply system for each cage for creating a life sustaining environment so that the animals can live in the rotating centrifuge for extended periods.

Design and construction of a cost-efficient Arduino-based mirror galvanometer system for scanning optical microscopy

NASA Astrophysics Data System (ADS)

Hsu, Jen-Feng; Dhingra, Shonali; D'Urso, Brian

2017-01-01

Mirror galvanometer systems (galvos) are commonly employed in research and commercial applications in areas involving laser imaging, laser machining, laser-light shows, and others. Here, we present a robust, moderate-speed, and cost-efficient home-built galvo system. The mechanical part of this design consists of one mirror, which is tilted around two axes with multiple surface transducers. We demonstrate the ability of this galvo by scanning the mirror using a computer, via a custom driver circuit. The performance of the galvo, including scan range, noise, linearity, and scan speed, is characterized. As an application, we show that this galvo system can be used in a confocal scanning microscopy system.

Fluorescence image excited by a scanning UV-LED light

NASA Astrophysics Data System (ADS)

Tsai, Hsin-Yi; Chen, Yi-Ju; Huang, Kuo-Cheng

2013-03-01

An optical scanning system using UV-LED light to induced fluorescence technology can enhance a fluorescence image significantly in a short period. It has several advantages such as lower power consumption, no scattering effect in skins, and multilayer images can be obtained to analyze skin disease. From the experiment results, the light intensity increases with increase spot size and decrease scanning speed, but the image resolution is oppositely. Moreover, the system could be widely used in clinical diagnosis and photodynamic therapy for skin disease because even the irradiated time of fluorescence substance is short but it will provide accurately positioning of fluorescence object.

Three-dimensional anterior segment imaging in patients with type 1 Boston Keratoprosthesis with switchable full depth range swept source optical coherence tomography

PubMed Central

Poddar, Raju; Cortés, Dennis E.; Werner, John S.; Mannis, Mark J.

2013-01-01

Abstract. A high-speed (100 kHz A-scans/s) complex conjugate resolved 1 μm swept source optical coherence tomography (SS-OCT) system using coherence revival of the light source is suitable for dense three-dimensional (3-D) imaging of the anterior segment. The short acquisition time helps to minimize the influence of motion artifacts. The extended depth range of the SS-OCT system allows topographic analysis of clinically relevant images of the entire depth of the anterior segment of the eye. Patients with the type 1 Boston Keratoprosthesis (KPro) require evaluation of the full anterior segment depth. Current commercially available OCT systems are not suitable for this application due to limited acquisition speed, resolution, and axial imaging range. Moreover, most commonly used research grade and some clinical OCT systems implement a commercially available SS (Axsun) that offers only 3.7 mm imaging range (in air) in its standard configuration. We describe implementation of a common swept laser with built-in k-clock to allow phase stable imaging in both low range and high range, 3.7 and 11.5 mm in air, respectively, without the need to build an external MZI k-clock. As a result, 3-D morphology of the KPro position with respect to the surrounding tissue could be investigated in vivo both at high resolution and with large depth range to achieve noninvasive and precise evaluation of success of the surgical procedure. PMID:23912759

Three-dimensional optical reconstruction of vocal fold kinematics using high-speed video with a laser projection system

PubMed Central

Luegmair, Georg; Mehta, Daryush D.; Kobler, James B.; Döllinger, Michael

2015-01-01

Vocal fold kinematics and its interaction with aerodynamic characteristics play a primary role in acoustic sound production of the human voice. Investigating the temporal details of these kinematics using high-speed videoendoscopic imaging techniques has proven challenging in part due to the limitations of quantifying complex vocal fold vibratory behavior using only two spatial dimensions. Thus, we propose an optical method of reconstructing the superior vocal fold surface in three spatial dimensions using a high-speed video camera and laser projection system. Using stereo-triangulation principles, we extend the camera-laser projector method and present an efficient image processing workflow to generate the three-dimensional vocal fold surfaces during phonation captured at 4000 frames per second. Initial results are provided for airflow-driven vibration of an ex vivo vocal fold model in which at least 75% of visible laser points contributed to the reconstructed surface. The method captures the vertical motion of the vocal folds at a high accuracy to allow for the computation of three-dimensional mucosal wave features such as vibratory amplitude, velocity, and asymmetry. PMID:26087485

Recognition Stage for a Speed Supervisor Based on Road Sign Detection

PubMed Central

Carrasco, Juan-Pablo; de la Escalera, Arturo; Armingol, José María

2012-01-01

Traffic accidents are still one of the main health problems in the World. A number of measures have been applied in order to reduce the number of injuries and fatalities in roads, i.e., implementation of Advanced Driver Assistance Systems (ADAS) based on image processing. In this paper, a real time speed supervisor based on road sign recognition that can work both in urban and non-urban environments is presented. The system is able to recognize 135 road signs, belonging to the danger, yield, prohibition obligation and indication types, and sends warning messages to the driver upon the combination of two pieces of information: the current speed of the car and the road sign symbol. The core of this paper is the comparison between the two main methods which have been traditionally used for detection and recognition of road signs: template matching (TM) and neural networks (NN). The advantages and disadvantages of the two approaches will be shown and commented. Additionally we will show how the use of well-known algorithms to avoid illumination issues reduces the amount of images needed to train a neural network.

High-speed single-pixel digital holography

NASA Astrophysics Data System (ADS)

González, Humberto; Martínez-León, Lluís.; Soldevila, Fernando; Araiza-Esquivel, Ma.; Tajahuerce, Enrique; Lancis, Jesús

2017-06-01

The complete phase and amplitude information of biological specimens can be easily determined by phase-shifting digital holography. Spatial light modulators (SLMs) based on liquid crystal technology, with a frame-rate around 60 Hz, have been employed in digital holography. In contrast, digital micro-mirror devices (DMDs) can reach frame rates up to 22 kHz. A method proposed by Lee to design computer generated holograms (CGHs) permits the use of such binary amplitude modulators as phase-modulation devices. Single-pixel imaging techniques record images by sampling the object with a sequence of micro-structured light patterns and using a simple photodetector. Our group has reported some approaches combining single-pixel imaging and phase-shifting digital holography. In this communication, we review these techniques and present the possibility of a high-speed single-pixel phase-shifting digital holography system with phase-encoded illumination. This system is based on a Mach-Zehnder interferometer, with a DMD acting as the modulator for projecting the sampling patterns on the object and also being used for phase-shifting. The proposed sampling functions are phaseencoded Hadamard patterns generated through a Lee hologram approach. The method allows the recording of the complex amplitude distribution of an object at high speed on account of the high frame rates of the DMD. Reconstruction may take just a few seconds. Besides, the optical setup is envisaged as a true adaptive system, which is able to measure the aberration induced by the optical system in the absence of a sample object, and then to compensate the wavefront in the phasemodulation stage.

S3: School Zone Safety System Based on Wireless Sensor Network

PubMed Central

Yoo, Seong-eun; Chong, Poh Kit; Kim, Daeyoung

2009-01-01

School zones are areas near schools that have lower speed limits and where illegally parked vehicles pose a threat to school children by obstructing them from the view of drivers. However, these laws are regularly flouted. Thus, we propose a novel wireless sensor network application called School zone Safety System (S3) to help regulate the speed limit and to prevent illegal parking in school zones. S3 detects illegally parked vehicles, and warns the driver and records the license plate number. To reduce the traveling speed of vehicles in a school zone, S3 measures the speed of vehicles and displays the speed to the driver via an LED display, and also captures the image of the speeding vehicle with a speed camera. We developed a state machine based vehicle detection algorithm for S3. From extensive experiments in our testbeds and data from a real school zone, it is shown that the system can detect all kinds of vehicles, and has an accuracy of over 95% for speed measurement. We modeled the battery life time of a sensor node and validated the model with a downscaled measurement; we estimate the battery life time to be over 2 years. We have deployed S3 in 15 school zones in 2007, and we have demonstrated the robustness of S3 by operating them for over 1 year. PMID:22454567

Development of an X-ray imaging system to prevent scintillator degradation for white synchrotron radiation.

PubMed

Zhou, Tunhe; Wang, Hongchang; Connolley, Thomas; Scott, Steward; Baker, Nick; Sawhney, Kawal

2018-05-01

The high flux of the white X-ray beams from third-generation synchrotron light sources can significantly benefit the development of high-speed X-ray imaging, but can also bring technical challenges to existing X-ray imaging systems. One prevalent problem is that the image quality deteriorates because of dust particles accumulating on the scintillator screen during exposure to intense X-ray radiation. Here, this problem has been solved by embedding the scintillator in a flowing inert-gas environment. It is also shown that the detector maintains the quality of the captured images even after days of X-ray exposure. This modification is cost-efficient and easy to implement. Representative examples of applications using the X-ray imaging system are also provided, including fast tomography and multimodal phase-contrast imaging for biomedical and geological samples. open access.

Optical diagnostics of mercury jet for an intense proton target.

PubMed

Park, H; Tsang, T; Kirk, H G; Ladeinde, F; Graves, V B; Spampinato, P T; Carroll, A J; Titus, P H; McDonald, K T

2008-04-01

An optical diagnostic system is designed and constructed for imaging a free mercury jet interacting with a high intensity proton beam in a pulsed high-field solenoid magnet. The optical imaging system employs a backilluminated, laser shadow photography technique. Object illumination and image capture are transmitted through radiation-hard multimode optical fibers and flexible coherent imaging fibers. A retroreflected illumination design allows the entire passive imaging system to fit inside the bore of the solenoid magnet. A sequence of synchronized short laser light pulses are used to freeze the transient events, and the images are recorded by several high speed charge coupled devices. Quantitative and qualitative data analysis using image processing based on probability approach is described. The characteristics of free mercury jet as a high power target for beam-jet interaction at various levels of the magnetic induction field is reported in this paper.

Development of an X-ray imaging system to prevent scintillator degradation for white synchrotron radiation

PubMed Central

Zhou, Tunhe; Wang, Hongchang; Scott, Steward

2018-01-01

The high flux of the white X-ray beams from third-generation synchrotron light sources can significantly benefit the development of high-speed X-ray imaging, but can also bring technical challenges to existing X-ray imaging systems. One prevalent problem is that the image quality deteriorates because of dust particles accumulating on the scintillator screen during exposure to intense X-ray radiation. Here, this problem has been solved by embedding the scintillator in a flowing inert-gas environment. It is also shown that the detector maintains the quality of the captured images even after days of X-ray exposure. This modification is cost-efficient and easy to implement. Representative examples of applications using the X-ray imaging system are also provided, including fast tomography and multimodal phase-contrast imaging for biomedical and geological samples. PMID:29714191

A Multiple Sensor Machine Vision System for Automatic Hardwood Feature Detection

Treesearch

D. Earl Kline; Richard W. Conners; Daniel L. Schmoldt; Philip A. Araman; Robert L. Brisbin

1993-01-01

A multiple sensor machine vision prototype is being developed to scan full size hardwood lumber at industrial speeds for automatically detecting features such as knots holes, wane, stain, splits, checks, and color. The prototype integrates a multiple sensor imaging system, a materials handling system, a computer system, and application software. The prototype provides...

Automatic Welding System of Aluminum Pipe by Monitoring Backside Image of Molten Pool Using Vision Sensor

NASA Astrophysics Data System (ADS)

Baskoro, Ario Sunar; Kabutomori, Masashi; Suga, Yasuo

An automatic welding system using Tungsten Inert Gas (TIG) welding with vision sensor for welding of aluminum pipe was constructed. This research studies the intelligent welding process of aluminum alloy pipe 6063S-T5 in fixed position and moving welding torch with the AC welding machine. The monitoring system consists of a vision sensor using a charge-coupled device (CCD) camera to monitor backside image of molten pool. The captured image was processed to recognize the edge of molten pool by image processing algorithm. Neural network model for welding speed control were constructed to perform the process automatically. From the experimental results it shows the effectiveness of the control system confirmed by good detection of molten pool and sound weld of experimental result.

Comparison of existing digital image analysis systems for the analysis of Thematic Mapper data

NASA Technical Reports Server (NTRS)

Likens, W. C.; Wrigley, R. C.

1984-01-01

Most existing image analysis systems were designed with the Landsat Multi-Spectral Scanner in mind, leaving open the question of whether or not these systems could adequately process Thematic Mapper data. In this report, both hardware and software systems have been evaluated for compatibility with TM data. Lack of spectral analysis capability was not found to be a problem, though techniques for spatial filtering and texture varied. Computer processing speed and data storage of currently existing mini-computer based systems may be less than adequate. Upgrading to more powerful hardware may be required for many TM applications.

Algorithm for Autonomous Landing

NASA Technical Reports Server (NTRS)

Kuwata, Yoshiaki

2011-01-01

Because of their small size, high maneuverability, and easy deployment, micro aerial vehicles (MAVs) are used for a wide variety of both civilian and military missions. One of their current drawbacks is the vast array of sensors (such as GPS, altimeter, radar, and the like) required to make a landing. Due to the MAV s small payload size, this is a major concern. Replacing the imaging sensors with a single monocular camera is sufficient to land a MAV. By applying optical flow algorithms to images obtained from the camera, time-to-collision can be measured. This is a measurement of position and velocity (but not of absolute distance), and can avoid obstacles as well as facilitate a landing on a flat surface given a set of initial conditions. The key to this approach is to calculate time-to-collision based on some image on the ground. By holding the angular velocity constant, horizontal speed decreases linearly with the height, resulting in a smooth landing. Mathematical proofs show that even with actuator saturation or modeling/ measurement uncertainties, MAVs can land safely. Landings of this nature may have a higher velocity than is desirable, but this can be compensated for by a cushioning or dampening system, or by using a system of legs to grab onto a surface. Such a monocular camera system can increase vehicle payload size (or correspondingly reduce vehicle size), increase speed of descent, and guarantee a safe landing by directly correlating speed to height from the ground.

Optical coherence tomography as a novel tool for in-line monitoring of a pharmaceutical film-coating process.

PubMed

Markl, Daniel; Hannesschläger, Günther; Sacher, Stephan; Leitner, Michael; Khinast, Johannes G

2014-05-13

Optical coherence tomography (OCT) is a contact-free non-destructive high-resolution imaging technique based on low-coherence interferometry. This study investigates the application of spectral-domain OCT as an in-line quality control tool for monitoring pharmaceutical film-coated tablets. OCT images of several commercially-available film-coated tablets of different shapes, formulations and coating thicknesses were captured off-line using two OCT systems with centre wavelengths of 830nm and 1325nm. Based on the off-line image evaluation, another OCT system operating at a shorter wavelength was selected to study the feasibility of OCT as an in-line monitoring method. Since in spectral-domain OCT motion artefacts can occur as a result of the tablet or sensor head movement, a basic understanding of the relationship between the tablet speed and the motion effects is essential for correct quantifying and qualifying of the tablet coating. Experimental data was acquired by moving the sensor head of the OCT system across a static tablet bed. Although examining the homogeneity of the coating turned more difficult with increasing transverse speed of the tablets, the determination of the coating thickness was still highly accurate at a speed up to 0.7m/s. The presented OCT setup enables the investigation of the intra- and inter-tablet coating uniformity in-line during the coating process. Copyright © 2014 Elsevier B.V. All rights reserved.

Shear wave speed recovery in sonoelastography using crawling wave data.

PubMed

Lin, Kui; McLaughlin, Joyce; Renzi, Daniel; Thomas, Ashley

2010-07-01

The crawling wave experiment, in which two harmonic sources oscillate at different but nearby frequencies, is a development in sonoelastography that allows real-time imaging of propagating shear wave interference patterns. Previously the crawling wave speed was recovered and used as an indicator of shear stiffness; however, it is shown in this paper that the crawling wave speed image can have artifacts that do not represent a change in stiffness. In this paper, the locations and shapes of some of the artifacts are exhibited. In addition, a differential equation is established that enables imaging of the shear wave speed, which is a quantity strongly correlated with shear stiffness change. The full algorithm is as follows: (1) extract the crawling wave phase from the spectral variance data; (2) calculate the crawling wave phase wave speed; (3) solve a first-order PDE for the phase of the wave emanating from one of the sources; and (4) compute and image the shear wave speed on a grid in the image plane.

Shear wave speed recovery in sonoelastography using crawling wave data

PubMed Central

Lin, Kui; McLaughlin, Joyce; Renzi, Daniel; Thomas, Ashley

2010-01-01

The crawling wave experiment, in which two harmonic sources oscillate at different but nearby frequencies, is a development in sonoelastography that allows real-time imaging of propagating shear wave interference patterns. Previously the crawling wave speed was recovered and used as an indicator of shear stiffness; however, it is shown in this paper that the crawling wave speed image can have artifacts that do not represent a change in stiffness. In this paper, the locations and shapes of some of the artifacts are exhibited. In addition, a differential equation is established that enables imaging of the shear wave speed, which is a quantity strongly correlated with shear stiffness change. The full algorithm is as follows: (1) extract the crawling wave phase from the spectral variance data; (2) calculate the crawling wave phase wave speed; (3) solve a first-order PDE for the phase of the wave emanating from one of the sources; and (4) compute and image the shear wave speed on a grid in the image plane. PMID:20649204

Structured illumination diffuse optical tomography for noninvasive functional neuroimaging in mice.

PubMed

Reisman, Matthew D; Markow, Zachary E; Bauer, Adam Q; Culver, Joseph P

2017-04-01

Optical intrinsic signal (OIS) imaging has been a powerful tool for capturing functional brain hemodynamics in rodents. Recent wide field-of-view implementations of OIS have provided efficient maps of functional connectivity from spontaneous brain activity in mice. However, OIS requires scalp retraction and is limited to superficial cortical tissues. Diffuse optical tomography (DOT) techniques provide noninvasive imaging, but previous DOT systems for rodent neuroimaging have been limited either by sparse spatial sampling or by slow speed. Here, we develop a DOT system with asymmetric source-detector sampling that combines the high-density spatial sampling (0.4 mm) detection of a scientific complementary metal-oxide-semiconductor camera with the rapid (2 Hz) imaging of a few ([Formula: see text]) structured illumination (SI) patterns. Analysis techniques are developed to take advantage of the system's flexibility and optimize trade-offs among spatial sampling, imaging speed, and signal-to-noise ratio. An effective source-detector separation for the SI patterns was developed and compared with light intensity for a quantitative assessment of data quality. The light fall-off versus effective distance was also used for in situ empirical optimization of our light model. We demonstrated the feasibility of this technique by noninvasively mapping the functional response in the somatosensory cortex of the mouse following electrical stimulation of the forepaw.

Nonlinear interferometric vibrational imaging of biological tissue

NASA Astrophysics Data System (ADS)

Jiang, Zhi; Marks, Daniel L.; Geddes, Joseph B., III; Boppart, Stephen A.

2008-02-01

We demonstrate imaging with the technique of nonlinear interferometric vibrational imaging (NIVI). Experimental images using this instrumentation and method have been acquired from both phantom and biological tissues. In our system, coherent anti-Stokes Raman scattering (CARS) signals are detected by spectral interferometry, which is able to fully restore high resolution Raman spectrum on each focal spot of a sample covering multiple Raman bands using broadband pump and Stokes laser beams. Spectral-domain detection has been demonstrated and allows for a significant increase in image acquiring speed, in signal-to-noise, and in interferometric signal stability.

Methods for CT automatic exposure control protocol translation between scanner platforms.

PubMed

McKenney, Sarah E; Seibert, J Anthony; Lamba, Ramit; Boone, John M

2014-03-01

An imaging facility with a diverse fleet of CT scanners faces considerable challenges when propagating CT protocols with consistent image quality and patient dose across scanner makes and models. Although some protocol parameters can comfortably remain constant among scanners (eg, tube voltage, gantry rotation time), the automatic exposure control (AEC) parameter, which selects the overall mA level during tube current modulation, is difficult to match among scanners, especially from different CT manufacturers. Objective methods for converting tube current modulation protocols among CT scanners were developed. Three CT scanners were investigated, a GE LightSpeed 16 scanner, a GE VCT scanner, and a Siemens Definition AS+ scanner. Translation of the AEC parameters such as noise index and quality reference mAs across CT scanners was specifically investigated. A variable-diameter poly(methyl methacrylate) phantom was imaged on the 3 scanners using a range of AEC parameters for each scanner. The phantom consisted of 5 cylindrical sections with diameters of 13, 16, 20, 25, and 32 cm. The protocol translation scheme was based on matching either the volumetric CT dose index or image noise (in Hounsfield units) between two different CT scanners. A series of analytic fit functions, corresponding to different patient sizes (phantom diameters), were developed from the measured CT data. These functions relate the AEC metric of the reference scanner, the GE LightSpeed 16 in this case, to the AEC metric of a secondary scanner. When translating protocols between different models of CT scanners (from the GE LightSpeed 16 reference scanner to the GE VCT system), the translation functions were linear. However, a power-law function was necessary to convert the AEC functions of the GE LightSpeed 16 reference scanner to the Siemens Definition AS+ secondary scanner, because of differences in the AEC functionality designed by these two companies. Protocol translation on the basis of quantitative metrics (volumetric CT dose index or measured image noise) is feasible. Protocol translation has a dependency on patient size, especially between the GE and Siemens systems. Translation schemes that preserve dose levels may not produce identical image quality. Copyright © 2014 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Design and implementation of non-linear image processing functions for CMOS image sensor

NASA Astrophysics Data System (ADS)

Musa, Purnawarman; Sudiro, Sunny A.; Wibowo, Eri P.; Harmanto, Suryadi; Paindavoine, Michel

2012-11-01

Today, solid state image sensors are used in many applications like in mobile phones, video surveillance systems, embedded medical imaging and industrial vision systems. These image sensors require the integration in the focal plane (or near the focal plane) of complex image processing algorithms. Such devices must meet the constraints related to the quality of acquired images, speed and performance of embedded processing, as well as low power consumption. To achieve these objectives, low-level analog processing allows extracting the useful information in the scene directly. For example, edge detection step followed by a local maxima extraction will facilitate the high-level processing like objects pattern recognition in a visual scene. Our goal was to design an intelligent image sensor prototype achieving high-speed image acquisition and non-linear image processing (like local minima and maxima calculations). For this purpose, we present in this article the design and test of a 64×64 pixels image sensor built in a standard CMOS Technology 0.35 μm including non-linear image processing. The architecture of our sensor, named nLiRIC (non-Linear Rapid Image Capture), is based on the implementation of an analog Minima/Maxima Unit. This MMU calculates the minimum and maximum values (non-linear functions), in real time, in a 2×2 pixels neighbourhood. Each MMU needs 52 transistors and the pitch of one pixel is 40×40 mu m. The total area of the 64×64 pixels is 12.5mm2. Our tests have shown the validity of the main functions of our new image sensor like fast image acquisition (10K frames per second), minima/maxima calculations in less then one ms.

A fast MEMS scanning photoacoustic microscopy system and its application in glioma study

NASA Astrophysics Data System (ADS)

Bi, Renzhe; Balasundaram, Ghayathri; Jeon, Seungwan; Pu, Yang; Tay, Hui Chien; Kim, Chulhong; Olivo, Malini

2018-02-01

We present a water-proof Microelectromechanical systems (MEMS) based scanning optical resolution Photoacoustic Microscopy (OR-PAM) system and its application in glioma tumor mouse model study. The presented OR-PAM system has high optical resolution ( 3 μm) and high scanning speed (up to 50 kHz A-scan rate), which is ideal for cerebral vascular imaging. In this study, the mice with glioma tumor are treated with vascular disrupting agent (VDA). OR-PAM system is utilized to image the cerebral with the whole skull intact before and after the injection of VDA. By image registration, the response of every single blood vessel can be traced. This will provide us deeper understanding of the drug effect.

An update of commercial infrared sensing and imaging instruments

NASA Technical Reports Server (NTRS)

Kaplan, Herbert

1989-01-01

A classification of infrared sensing instruments by type and application, listing commercially available instruments, from single point thermal probes to on-line control sensors, to high speed, high resolution imaging systems is given. A review of performance specifications follows, along with a discussion of typical thermographic display approaches utilized by various imager manufacturers. An update report on new instruments, new display techniques and newly introduced features of existing instruments is given.

Ultra-high-speed 3D astigmatic particle tracking velocimetry: application to particle-laden supersonic impinging jets

NASA Astrophysics Data System (ADS)

Buchmann, N. A.; Cierpka, C.; Kähler, C. J.; Soria, J.

2014-11-01

The paper demonstrates ultra-high-speed three-component, three-dimensional (3C3D) velocity measurements of micron-sized particles suspended in a supersonic impinging jet flow. Understanding the dynamics of individual particles in such flows is important for the design of particle impactors for drug delivery or cold gas dynamic spray processing. The underexpanded jet flow is produced via a converging nozzle, and micron-sized particles ( d p = 110 μm) are introduced into the gas flow. The supersonic jet impinges onto a flat surface, and the particle impact velocity and particle impact angle are studied for a range of flow conditions and impingement distances. The imaging system consists of an ultra-high-speed digital camera (Shimadzu HPV-1) capable of recording rates of up to 1 Mfps. Astigmatism particle tracking velocimetry (APTV) is used to measure the 3D particle position (Cierpka et al., Meas Sci Technol 21(045401):13, 2010) by coding the particle depth location in the 2D images by adding a cylindrical lens to the high-speed imaging system. Based on the reconstructed 3D particle positions, the particle trajectories are obtained via a higher-order tracking scheme that takes advantage of the high temporal resolution to increase robustness and accuracy of the measurement. It is shown that the particle velocity and impingement angle are affected by the gas flow in a manner depending on the nozzle pressure ratio and stand-off distance where higher pressure ratios and stand-off distances lead to higher impact velocities and larger impact angles.

Adaptive AFM scan speed control for high aspect ratio fast structure tracking

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ahmad, Ahmad; Schuh, Andreas; Rangelow, Ivo W.

2014-10-15

Improved imaging rates in Atomic Force Microscopes (AFM) are of high interest for disciplines such as life sciences and failure analysis of semiconductor wafers, where the sample topology shows high aspect ratios. Also, fast imaging is necessary to cover a large surface under investigation in reasonable times. Since AFMs are composed of mechanical components, they are associated with comparably low resonance frequencies that undermine the effort to increase the acquisition rates. In particular, high and steep structures are difficult to follow, which causes the cantilever to temporarily loose contact to or crash into the sample. Here, we report on amore » novel approach that does not affect the scanner dynamics, but adapts the lateral scanning speed of the scanner. The controller monitors the control error signal and, only when necessary, decreases the scan speed to allow the z-piezo more time to react to changes in the sample's topography. In this case, the overall imaging rate can be significantly increased, because a general scan speed trade-off decision is not needed and smooth areas are scanned fast. In contrast to methods trying to increase the z-piezo bandwidth, our method is a comparably simple approach that can be easily adapted to standard systems.« less

Ultrahigh speed Spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second

PubMed Central

Potsaid, Benjamin; Gorczynska, Iwona; Srinivasan, Vivek J.; Chen, Yueli; Jiang, James; Cable, Alex; Fujimoto, James G.

2009-01-01

We demonstrate ultrahigh speed spectral / Fourier domain optical coherence tomography (OCT) using an ultrahigh speed CMOS line scan camera at rates of 70,000 - 312,500 axial scans per second. Several design configurations are characterized to illustrate trade-offs between acquisition speed, resolution, imaging range, sensitivity and sensitivity roll-off performance. Ultrahigh resolution OCT with 2.5 - 3.0 micron axial image resolution is demonstrated at ∼ 100,000 axial scans per second. A high resolution spectrometer design improves sensitivity roll-off and imaging range performance, trading off imaging speed to 70,000 axial scans per second. Ultrahigh speed imaging at >300,000 axial scans per second with standard image resolution is also demonstrated. Ophthalmic OCT imaging of the normal human retina is investigated. The high acquisition speeds enable dense raster scanning to acquire densely sampled volumetric three dimensional OCT (3D-OCT) data sets of the macula and optic disc with minimal motion artifacts. Imaging with ∼ 8 - 9 micron axial resolution at 250,000 axial scans per second, a 512 × 512 × 400 voxel volumetric 3D-OCT data set can be acquired in only ∼ 1.3 seconds. Orthogonal registration scans are used to register OCT raster scans and remove residual axial eye motion, resulting in 3D-OCT data sets which preserve retinal topography. Rapid repetitive imaging over small volumes can visualize small retinal features without motion induced distortions and enables volume registration to remove eye motion. Cone photoreceptors in some regions of the retina can be visualized without adaptive optics or active eye tracking. Rapid repetitive imaging of 3D volumes also provides dynamic volumetric information (4D-OCT) which is shown to enhance visualization of retinal capillaries and should enable functional imaging. Improvements in the speed and performance of 3D-OCT volumetric imaging promise to enable earlier diagnosis and improved monitoring of disease progression and response to therapy in ophthalmology, as well as have a wide range of research and clinical applications in other areas. PMID:18795054

Implementation of real-time nonuniformity correction with multiple NUC tables using FPGA in an uncooled imaging system

NASA Astrophysics Data System (ADS)

Oh, Gyong Jin; Kim, Lyang-June; Sheen, Sue-Ho; Koo, Gyou-Phyo; Jin, Sang-Hun; Yeo, Bo-Yeon; Lee, Jong-Ho

2009-05-01

This paper presents a real time implementation of Non Uniformity Correction (NUC). Two point correction and one point correction with shutter were carried out in an uncooled imaging system which will be applied to a missile application. To design a small, light weight and high speed imaging system for a missile system, SoPC (System On a Programmable Chip) which comprises of FPGA and soft core (Micro-blaze) was used. Real time NUC and generation of control signals are implemented using FPGA. Also, three different NUC tables were made to make the operating time shorter and to reduce the power consumption in a large range of environment temperature. The imaging system consists of optics and four electronics boards which are detector interface board, Analog to Digital converter board, Detector signal generation board and Power supply board. To evaluate the imaging system, NETD was measured. The NETD was less than 160mK in three different environment temperatures.

High speed automated microtomography of nuclear emulsions and recent application

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tioukov, V.; Aleksandrov, A.; Consiglio, L.

2015-12-31

The development of high-speed automatic scanning systems was the key-factor for massive and successful emulsions application for big neutrino experiments like OPERA. The emulsion detector simplicity, the unprecedented sub-micron spatial resolution and the unique ability to provide intrinsically 3-dimensional spatial information make it a perfect device for short-living particles study, where the event topology should be precisely reconstructed in a 10-100 um scale vertex region. Recently the exceptional technological progress in image processing and automation together with intensive R&D done by Italian and Japanese microscopy groups permit to increase the scanning speed to unbelievable few years ago m{sup 2}/day scalemore » and so greatly extend the range of the possible applications for emulsion-based detectors to other fields like: medical imaging, directional dark matter search, nuclear physics, geological and industrial applications.« less

Three-Dimensional ISAR Imaging Method for High-Speed Targets in Short-Range Using Impulse Radar Based on SIMO Array

PubMed Central

Zhou, Xinpeng; Wei, Guohua; Wu, Siliang; Wang, Dawei

2016-01-01

This paper proposes a three-dimensional inverse synthetic aperture radar (ISAR) imaging method for high-speed targets in short-range using an impulse radar. According to the requirements for high-speed target measurement in short-range, this paper establishes the single-input multiple-output (SIMO) antenna array, and further proposes a missile motion parameter estimation method based on impulse radar. By analyzing the motion geometry relationship of the warhead scattering center after translational compensation, this paper derives the receiving antenna position and the time delay after translational compensation, and thus overcomes the shortcomings of conventional translational compensation methods. By analyzing the motion characteristics of the missile, this paper estimates the missile’s rotation angle and the rotation matrix by establishing a new coordinate system. Simulation results validate the performance of the proposed algorithm. PMID:26978372

Self-calibrated correlation imaging with k-space variant correlation functions.

PubMed

Li, Yu; Edalati, Masoud; Du, Xingfu; Wang, Hui; Cao, Jie J

2018-03-01

Correlation imaging is a previously developed high-speed MRI framework that converts parallel imaging reconstruction into the estimate of correlation functions. The presented work aims to demonstrate this framework can provide a speed gain over parallel imaging by estimating k-space variant correlation functions. Because of Fourier encoding with gradients, outer k-space data contain higher spatial-frequency image components arising primarily from tissue boundaries. As a result of tissue-boundary sparsity in the human anatomy, neighboring k-space data correlation varies from the central to the outer k-space. By estimating k-space variant correlation functions with an iterative self-calibration method, correlation imaging can benefit from neighboring k-space data correlation associated with both coil sensitivity encoding and tissue-boundary sparsity, thereby providing a speed gain over parallel imaging that relies only on coil sensitivity encoding. This new approach is investigated in brain imaging and free-breathing neonatal cardiac imaging. Correlation imaging performs better than existing parallel imaging techniques in simulated brain imaging acceleration experiments. The higher speed enables real-time data acquisition for neonatal cardiac imaging in which physiological motion is fast and non-periodic. With k-space variant correlation functions, correlation imaging gives a higher speed than parallel imaging and offers the potential to image physiological motion in real-time. Magn Reson Med 79:1483-1494, 2018. © 2017 International Society for Magnetic Resonance in Medicine. © 2017 International Society for Magnetic Resonance in Medicine.

Ultrahigh speed endoscopic optical coherence tomography using micromotor imaging catheter and VCSEL technology.

PubMed

Tsai, Tsung-Han; Potsaid, Benjamin; Tao, Yuankai K; Jayaraman, Vijaysekhar; Jiang, James; Heim, Peter J S; Kraus, Martin F; Zhou, Chao; Hornegger, Joachim; Mashimo, Hiroshi; Cable, Alex E; Fujimoto, James G

2013-07-01

We developed a micromotor based miniature catheter with an outer diameter of 3.2 mm for ultrahigh speed endoscopic swept source optical coherence tomography (OCT) using a vertical cavity surface-emitting laser (VCSEL) at a 1 MHz axial scan rate. The micromotor can rotate a micro-prism at several hundred frames per second with less than 5 V drive voltage to provide fast and stable scanning, which is not sensitive to the bending of the catheter. The side-viewing probe can be pulled back to acquire a three-dimensional (3D) data set covering a large area on the specimen. The VCSEL provides a high axial scan rate to support dense sampling under high frame rate operation. Using a high speed data acquisition system, in vivo 3D-OCT imaging in the rabbit GI tract and ex vivo imaging of a human colon specimen with 8 μm axial resolution, 8 μm lateral resolution and 1.2 mm depth range in tissue at a frame rate of 400 fps was demonstrated.

Ultrahigh speed endoscopic optical coherence tomography using micromotor imaging catheter and VCSEL technology

PubMed Central

Tsai, Tsung-Han; Potsaid, Benjamin; Tao, Yuankai K.; Jayaraman, Vijaysekhar; Jiang, James; Heim, Peter J. S.; Kraus, Martin F.; Zhou, Chao; Hornegger, Joachim; Mashimo, Hiroshi; Cable, Alex E.; Fujimoto, James G.

2013-01-01

We developed a micromotor based miniature catheter with an outer diameter of 3.2 mm for ultrahigh speed endoscopic swept source optical coherence tomography (OCT) using a vertical cavity surface-emitting laser (VCSEL) at a 1 MHz axial scan rate. The micromotor can rotate a micro-prism at several hundred frames per second with less than 5 V drive voltage to provide fast and stable scanning, which is not sensitive to the bending of the catheter. The side-viewing probe can be pulled back to acquire a three-dimensional (3D) data set covering a large area on the specimen. The VCSEL provides a high axial scan rate to support dense sampling under high frame rate operation. Using a high speed data acquisition system, in vivo 3D-OCT imaging in the rabbit GI tract and ex vivo imaging of a human colon specimen with 8 μm axial resolution, 8 μm lateral resolution and 1.2 mm depth range in tissue at a frame rate of 400 fps was demonstrated. PMID:23847737

Real-time X-ray Diffraction: Applications to Materials Characterization

NASA Technical Reports Server (NTRS)

Rosemeier, R. G.

1984-01-01

With the high speed growth of materials it becomes necessary to develop measuring systems which also have the capabilities of characterizing these materials at high speeds. One of the conventional techniques of characterizing materials was X-ray diffraction. Film, which is the oldest method of recording the X-ray diffraction phenomenon, is not quite adequate in most circumstances to record fast changing events. Even though conventional proportional counters and scintillation counters can provide the speed necessary to record these changing events, they lack the ability to provide image information which may be important in some types of experiment or production arrangements. A selected number of novel applications of using X-ray diffraction to characterize materials in real-time are discussed. Also, device characteristics of some X-ray intensifiers useful in instantaneous X-ray diffraction applications briefly presented. Real-time X-ray diffraction experiments with the incorporation of image X-ray intensification add a new dimension in the characterization of materials. The uses of real-time image intensification in laboratory and production arrangements are quite unlimited and their application depends more upon the ingenuity of the scientist or engineer.

Quantification of the ciliary muscle and crystalline lens interaction during accommodation with synchronous OCT imaging

PubMed Central

Ruggeri, Marco; de Freitas, Carolina; Williams, Siobhan; Hernandez, Victor M.; Cabot, Florence; Yesilirmak, Nilufer; Alawa, Karam; Chang, Yu-Cherng; Yoo, Sonia H.; Gregori, Giovanni; Parel, Jean-Marie; Manns, Fabrice

2016-01-01

Abstract: Two SD-OCT systems and a dual channel accommodation target were combined and precisely synchronized to simultaneously image the anterior segment and the ciliary muscle during dynamic accommodation. The imaging system simultaneously generates two synchronized OCT image sequences of the anterior segment and ciliary muscle with an imaging speed of 13 frames per second. The system was used to acquire OCT image sequences of a non-presbyopic and a pre-presbyopic subject accommodating in response to step changes in vergence. The image sequences were processed to extract dynamic morphological data from the crystalline lens and the ciliary muscle. The synchronization between the OCT systems allowed the precise correlation of anatomical changes occurring in the crystalline lens and ciliary muscle at identical time points during accommodation. To describe the dynamic interaction between the crystalline lens and ciliary muscle, we introduce accommodation state diagrams that display the relation between anatomical changes occurring in the accommodating crystalline lens and ciliary muscle. PMID:27446660

Quantification of the ciliary muscle and crystalline lens interaction during accommodation with synchronous OCT imaging.

PubMed

Ruggeri, Marco; de Freitas, Carolina; Williams, Siobhan; Hernandez, Victor M; Cabot, Florence; Yesilirmak, Nilufer; Alawa, Karam; Chang, Yu-Cherng; Yoo, Sonia H; Gregori, Giovanni; Parel, Jean-Marie; Manns, Fabrice

2016-04-01

Two SD-OCT systems and a dual channel accommodation target were combined and precisely synchronized to simultaneously image the anterior segment and the ciliary muscle during dynamic accommodation. The imaging system simultaneously generates two synchronized OCT image sequences of the anterior segment and ciliary muscle with an imaging speed of 13 frames per second. The system was used to acquire OCT image sequences of a non-presbyopic and a pre-presbyopic subject accommodating in response to step changes in vergence. The image sequences were processed to extract dynamic morphological data from the crystalline lens and the ciliary muscle. The synchronization between the OCT systems allowed the precise correlation of anatomical changes occurring in the crystalline lens and ciliary muscle at identical time points during accommodation. To describe the dynamic interaction between the crystalline lens and ciliary muscle, we introduce accommodation state diagrams that display the relation between anatomical changes occurring in the accommodating crystalline lens and ciliary muscle.

Development of online lines-scan imaging system for chicken inspection and differentiation

NASA Astrophysics Data System (ADS)

Yang, Chun-Chieh; Chan, Diane E.; Chao, Kuanglin; Chen, Yud-Ren; Kim, Moon S.

2006-10-01

An online line-scan imaging system was developed for differentiation of wholesome and systemically diseased chickens. The hyperspectral imaging system used in this research can be directly converted to multispectral operation and would provide the ideal implementation of essential features for data-efficient high-speed multispectral classification algorithms. The imaging system consisted of an electron-multiplying charge-coupled-device (EMCCD) camera and an imaging spectrograph for line-scan images. The system scanned the surfaces of chicken carcasses on an eviscerating line at a poultry processing plant in December 2005. A method was created to recognize birds entering and exiting the field of view, and to locate a Region of Interest on the chicken images from which useful spectra were extracted for analysis. From analysis of the difference spectra between wholesome and systemically diseased chickens, four wavelengths of 468 nm, 501 nm, 582 nm and 629 nm were selected as key wavelengths for differentiation. The method of locating the Region of Interest will also have practical application in multispectral operation of the line-scan imaging system for online chicken inspection. This line-scan imaging system makes possible the implementation of multispectral inspection using the key wavelengths determined in this study with minimal software adaptations and without the need for cross-system calibration.

The Hico Image Processing System: A Web-Accessible Hyperspectral Remote Sensing Toolbox

NASA Astrophysics Data System (ADS)

Harris, A. T., III; Goodman, J.; Justice, B.

2014-12-01

As the quantity of Earth-observation data increases, the use-case for hosting analytical tools in geospatial data centers becomes increasingly attractive. To address this need, HySpeed Computing and Exelis VIS have developed the HICO Image Processing System, a prototype cloud computing system that provides online, on-demand, scalable remote sensing image processing capabilities. The system provides a mechanism for delivering sophisticated image processing analytics and data visualization tools into the hands of a global user community, who will only need a browser and internet connection to perform analysis. Functionality of the HICO Image Processing System is demonstrated using imagery from the Hyperspectral Imager for the Coastal Ocean (HICO), an imaging spectrometer located on the International Space Station (ISS) that is optimized for acquisition of aquatic targets. Example applications include a collection of coastal remote sensing algorithms that are directed at deriving critical information on water and habitat characteristics of our vulnerable coastal environment. The project leverages the ENVI Services Engine as the framework for all image processing tasks, and can readily accommodate the rapid integration of new algorithms, datasets and processing tools.

Photoacoustic imaging of lymphatic pumping

NASA Astrophysics Data System (ADS)

Forbrich, Alex; Heinmiller, Andrew; Zemp, Roger J.

2017-10-01

The lymphatic system is responsible for fluid homeostasis and immune cell trafficking and has been implicated in several diseases, including obesity, diabetes, and cancer metastasis. Despite its importance, the lack of suitable in vivo imaging techniques has hampered our understanding of the lymphatic system. This is, in part, due to the limited contrast of lymphatic fluids and structures. Photoacoustic imaging, in combination with optically absorbing dyes or nanoparticles, has great potential for noninvasively visualizing the lymphatic vessels deep in tissues. Multispectral photoacoustic imaging is capable of separating the components; however, the slow wavelength switching speed of most laser systems is inadequate for imaging lymphatic pumping without motion artifacts being introduced into the processed images. We investigate two approaches for visualizing lymphatic processes in vivo. First, single-wavelength differential photoacoustic imaging is used to visualize lymphatic pumping in the hindlimb of a mouse in real time. Second, a fast-switching multiwavelength photoacoustic imaging system was used to assess the propulsion profile of dyes through the lymphatics in real time. These approaches may have profound impacts in noninvasively characterizing and investigating the lymphatic system.