Design and comparative study of vertical LEDs with graphene, ITO and Ni/Au as contact/current spreading layer

NASA Astrophysics Data System (ADS)

Singh, Sumitra; Mahala, Pramila; Pal, Suchandan

2018-01-01

This work evaluates the effect of graphene, indium tin oxide (ITO) and Ni/Au as contact/current spreading layer/current spreading layer for GaN vertical light emitting diodes (V-LEDs). In this simulation study, the effect of these contact/current spreading layers on different performance parameters of GaN V-LEDs has been studied. By using these three different types of contact/current spreading layers, we have comparatively studied the effect on light extraction efficiency (LEE), optical output power, wall plug efficiency and radiant intensity of V-LEDs. As per the simulation results, it shows that using graphene contact/current spreading layers, it is possible to achieve better performance than using ITO and Ni/Au contact/current spreading layers. For graphene/(Ni/Au) contact/current spreading layers, the LEE is improved by 36.77% whereas for ITO/(Ni/Au) contact/current spreading layers it is improved by 13.74%. Also, by using graphene/(Ni/Au) contact/current spreading layers, the optical output power of LEDs improved by 11.11% whereas for ITO/(Ni/Au) contact/current spreading layers shown 4.16% improvement. The radiant intensity is enhanced by 37.65% for graphene/(Ni/Au) contact/current spreading layers and 13.5% for ITO/(Ni/Au) contact/current spreading layers. In this report, we have given a detailed analysis of the obtained simulation results. The simulation was carried out in SimuLED tool.

A study of flame spread in engineered cardboard fuelbeds: Part I: Correlations and observations

Treesearch

Mark A. Finney; Jason Forthofer; Isaac C. Grenfell; Brittany A. Adam; Nelson K. Akafuah; Kozo Saito

2013-01-01

Wind tunnel laboratory fires spreading through laser-cut cardboard fuel beds were instrumented and analyzed for physical processes associated with spread. Flames in the span-wise direction appeared as a regular series of peaks-and-troughs that scaled directly with flame length. Flame structure in the stream-wise direction fluctuated with the forward advection of...

Research on Free Electron Lasers

DTIC Science & Technology

1989-01-01

<exp(Aa)vo) >A = exp((YG -o/2) (67) For the exponential distribution function is another example that results from a symmetric angular spread in the...vo = 47 when there is an angular spread. This indicates that the actual peak moves to the right when 00 increases. The last term term decreases the...value of the gain at vo = F7 when either the angular spread ag or energy spread OG increases. 10. SPIE FEL Review Paper During the contracting period

A NON-PRE DOUBLE-PEAKED BURST FROM 4U 1636-536: EVIDENCE FOR BURNING FRONT PROPAGATION

NASA Technical Reports Server (NTRS)

Bhattacharyya, Sudip; Strohmayer, Tod E.

2005-01-01

We analyse Rossi X-ray Timing Explorer (RXTE) Proportional Counter Array (PCA) data of a double-peaked burst from the low mass X-ray binary (LMXB) 4U 1636-536 that shows no evidence for photospheric radius expansion (PRE). We find that the X-ray emitting area on the star increases with time as the burst progresses, even though the photosphere does not expand. We argue that this is a strong indication of thermonuclear flame spreading on the stellar surface during such bursts. We propose a model for such double-peaked bursts, based on thermonuclear flame spreading, that can qualitatively explain their essential features, as well as the rarity of these bursts.

Image characterization metrics for muon tomography

NASA Astrophysics Data System (ADS)

Luo, Weidong; Lehovich, Andre; Anashkin, Edward; Bai, Chuanyong; Kindem, Joel; Sossong, Michael; Steiger, Matt

2014-05-01

Muon tomography uses naturally occurring cosmic rays to detect nuclear threats in containers. Currently there are no systematic image characterization metrics for muon tomography. We propose a set of image characterization methods to quantify the imaging performance of muon tomography. These methods include tests of spatial resolution, uniformity, contrast, signal to noise ratio (SNR) and vertical smearing. Simulated phantom data and analysis methods were developed to evaluate metric applicability. Spatial resolution was determined as the FWHM of the point spread functions in X, Y and Z axis for 2.5cm tungsten cubes. Uniformity was measured by drawing a volume of interest (VOI) within a large water phantom and defined as the standard deviation of voxel values divided by the mean voxel value. Contrast was defined as the peak signals of a set of tungsten cubes divided by the mean voxel value of the water background. SNR was defined as the peak signals of cubes divided by the standard deviation (noise) of the water background. Vertical smearing, i.e. vertical thickness blurring along the zenith axis for a set of 2 cm thick tungsten plates, was defined as the FWHM of vertical spread function for the plate. These image metrics provided a useful tool to quantify the basic imaging properties for muon tomography.

Resolving vorticity-driven lateral fire spread using the WRF-Fire coupled atmosphere-fire numerical model

NASA Astrophysics Data System (ADS)

Simpson, C. C.; Sharples, J. J.; Evans, J. P.

2014-05-01

Fire channelling is a form of dynamic fire behaviour, during which a wildland fire spreads rapidly across a steep lee-facing slope in a direction transverse to the background winds, and is often accompanied by a downwind extension of the active flaming region and extreme pyro-convection. Recent work using the WRF-Fire coupled atmosphere-fire model has demonstrated that fire channelling can be characterised as vorticity-driven lateral fire spread (VDLS). In this study, 16 simulations are conducted using WRF-Fire to examine the sensitivity of resolving VDLS to spatial resolution and atmosphere-fire coupling within the WRF-Fire model framework. The horizontal grid spacing is varied between 25 and 90 m, and the two-way atmosphere-fire coupling is either enabled or disabled. At high spatial resolution, the atmosphere-fire coupling increases the peak uphill and lateral spread rate by a factor of up to 2.7 and 9.5. The enhancement of the uphill and lateral spread rate diminishes at coarser spatial resolution, and VDLS is not modelled for a horizontal grid spacing of 90 m. The laterally spreading fire fronts become the dominant contributors of the extreme pyro-convection. The resolved fire-induced vortices responsible for driving the lateral spread in the coupled simulations have non-zero vorticity along each unit vector direction, and develop due to an interaction between the background winds and vertical return circulations generated at the flank of the fire front as part of the pyro-convective updraft. The results presented in this study demonstrate that both high spatial resolution and two-way atmosphere-fire coupling are required to reproduce VDLS within the current WRF-Fire model framework.

Predictive Validation of an Influenza Spread Model

PubMed Central

Hyder, Ayaz; Buckeridge, David L.; Leung, Brian

2013-01-01

Background Modeling plays a critical role in mitigating impacts of seasonal influenza epidemics. Complex simulation models are currently at the forefront of evaluating optimal mitigation strategies at multiple scales and levels of organization. Given their evaluative role, these models remain limited in their ability to predict and forecast future epidemics leading some researchers and public-health practitioners to question their usefulness. The objective of this study is to evaluate the predictive ability of an existing complex simulation model of influenza spread. Methods and Findings We used extensive data on past epidemics to demonstrate the process of predictive validation. This involved generalizing an individual-based model for influenza spread and fitting it to laboratory-confirmed influenza infection data from a single observed epidemic (1998–1999). Next, we used the fitted model and modified two of its parameters based on data on real-world perturbations (vaccination coverage by age group and strain type). Simulating epidemics under these changes allowed us to estimate the deviation/error between the expected epidemic curve under perturbation and observed epidemics taking place from 1999 to 2006. Our model was able to forecast absolute intensity and epidemic peak week several weeks earlier with reasonable reliability and depended on the method of forecasting-static or dynamic. Conclusions Good predictive ability of influenza epidemics is critical for implementing mitigation strategies in an effective and timely manner. Through the process of predictive validation applied to a current complex simulation model of influenza spread, we provided users of the model (e.g. public-health officials and policy-makers) with quantitative metrics and practical recommendations on mitigating impacts of seasonal influenza epidemics. This methodology may be applied to other models of communicable infectious diseases to test and potentially improve their predictive ability. PMID:23755236

Lateral spread of sonic boom measurements from US Air Force boomfile flight tests

NASA Technical Reports Server (NTRS)

Downing, J. Micah

1992-01-01

A series of sonic boom flight tests were conducted by the US Air Force at Edwards AFB in 1987 with current supersonic DOD aircraft. These tests involved 43 flights by various aircraft at different Mach number and altitude combinations. The measured peak overpressures to predicted values as a function of lateral distance are compared. Some of the flights are combined into five groups because of the varying profiles and the limited number of sonic booms obtained during this study. The peak overpressures and the lateral distances are normalized with respect to the Carlson method predicted centerline overpressures and lateral cutoff distances, respectively, to facilitate comparisons between sonic boom data from similar flight profiles. It is demonstrated that the data agrees with sonic boom theory and previous studies and adds to the existing sonic boom database by including sonic boom signatures, tracking, and weather data in a digital format.

Tidal and near-inertial peak variations around the diurnal critical latitude

NASA Astrophysics Data System (ADS)

van Haren, Hans

2005-12-01

Spectra from historic long-term open-ocean moored current meter data between latitudes 0° < |$\\varphi$| < 45° reveal a significant drop in semidiurnal tidal band (D2) energy by ~50% at |$\\varphi$| ~ 25-27°, whilst the peak near the local inertial frequency f is increased by a factor of ~10 up to the level of D2-energy at |$\\varphi$| ~ 28-30°, where f coincides with diurnal frequencies. The increase in f-energy is accompanied by a red-shift of the peak frequency to 0.97 +/- 0.01f, or a poleward spreading of enhanced energy. This contrasts with more common blue-shift. The enhancement may be the result of sub-harmonic instability, as supported by sparse significant bicoherence at half-D2, although i) systematic enhancement of diurnal tidal frequencies, notably M1, was not observed, ii) the latitudes of low D2-energy and high f-energy do not coincide. This may be due to a mix of coupled and independent waves, whilst the poleward trapping of sub-f energy suggests non-traditional effects.

Emerged HA and NA Mutants of the Pandemic Influenza H1N1 Viruses with Increasing Epidemiological Significance in Taipei and Kaohsiung, Taiwan, 2009–10

PubMed Central

Kao, Chuan-Liang; Chan, Ta-Chien; Tsai, Chu-Han; Chu, Kuan-Ying; Chuang, Shu-Fang; Lee, Chang-Chun; Li, Zheng-Rong Tiger; Wu, Ko-Wen; Chang, Luan-Yin; Shen, Yea-Huei; Huang, Li-Min; Lee, Ping-Ing; Yang, ChingLai; Compans, Richard; Rouse, Barry T.; King, Chwan-Chuen

2012-01-01

The 2009 influenza pandemic provided an opportunity to observe dynamic changes of the hemagglutinin (HA) and neuraminidase (NA) of pH1N1 strains that spread in two metropolitan areas -Taipei and Kaohsiung. We observed cumulative increases of amino acid substitutions of both HA and NA that were higher in the post–peak than in the pre-peak period of the epidemic. About 14.94% and 3.44% of 174 isolates had one and two amino acids changes, respective, in the four antigenic sites. One unique adaptive mutation of HA2 (E374K) was first detected three weeks before the epidemic peak. This mutation evolved through the epidemic, and finally emerged as the major circulated strain, with significantly higher frequency in the post-peak period than in the pre-peak (64.65% vs 9.28%, p<0.0001). E374K persisted until ten months post-nationwide vaccination without further antigenic changes (e.g. prior to the highest selective pressure). In public health measures, the epidemic peaked at seven weeks after oseltamivir treatment was initiated. The emerging E374K mutants spread before the first peak of school class suspension, extended their survival in high-density population areas before vaccination, dominated in the second wave of class suspension, and were fixed as herd immunity developed. The tempo-spatial spreading of E374K mutants was more concentrated during the post–peak (p = 0.000004) in seven districts with higher spatial clusters (p<0.001). This is the first study examining viral changes during the naïve phase of a pandemic of influenza through integrated virological/serological/clinical surveillance, tempo-spatial analysis, and intervention policies. The vaccination increased the percentage of E374K mutants (22.86% vs 72.34%, p<0.001) and significantly elevated the frequency of mutations in Sa antigenic site (2.36% vs 23.40%, p<0.001). Future pre-vaccination public health efforts should monitor amino acids of HA and NA of pandemic influenza viruses isolated at exponential and peak phases in areas with high cluster cases. PMID:22328930

Influence of the spatially inhomogeneous gap distribution on the quasiparticle current in c-axis junctions involving d-wave superconductors with charge density waves.

PubMed

Ekino, T; Gabovich, A M; Suan Li, Mai; Szymczak, H; Voitenko, A I

2016-11-09

The quasiparticle tunnel current J(V) between the superconducting ab-planes along the c-axis and the corresponding conductance [Formula: see text] were calculated for symmetric junctions composed of disordered d-wave layered superconductors partially gapped by charge density waves (CDWs). Here, V is the voltage. Both the checkerboard and unidirectional CDWs were considered. It was shown that the spatial spread of the CDW-pairing strength substantially smears the peculiarities of G(V) appropriate to uniform superconductors. The resulting curves G(V) become very similar to those observed for a number of cuprates in intrinsic junctions, e.g. mesas. In particular, the influence of CDWs may explain the peak-dip-hump structures frequently found for high-T c oxides.

Effects of spatial heterogeneity in moisture content on the horizontal spread of peat fires.

PubMed

Prat-Guitart, Nuria; Rein, Guillermo; Hadden, Rory M; Belcher, Claire M; Yearsley, Jon M

2016-12-01

The gravimetric moisture content of peat is the main factor limiting the ignition and spread propagation of smouldering fires. Our aim is to use controlled laboratory experiments to better understand how the spread of smouldering fires is influenced in natural landscape conditions where the moisture content of the top peat layer is not homogeneous. In this paper, we study for the first time the spread of peat fires across a spatial matrix of two moisture contents (dry/wet) in the laboratory. The experiments were undertaken using an open-top insulated box (22×18×6cm) filled with milled peat. The peat was ignited at one side of the box initiating smouldering and horizontal spread. Measurements of the peak temperature inside the peat, fire duration and longwave thermal radiation from the burning samples revealed important local changes of the smouldering behaviour in response to sharp gradients in moisture content. Both, peak temperatures and radiation in wetter peat (after the moisture gradient) were sensitive to the drier moisture condition (preceding the moisture gradient). Drier peat conditions before the moisture gradient led to higher temperatures and higher radiation flux from the fire during the first 6cm of horizontal spread into a wet peat patch. The total spread distance into a wet peat patch was affected by the moisture content gradient. We predicted that in most peat moisture gradients of relevance to natural ecosystems the fire self-extinguishes within the first 10cm of horizontal spread into a wet peat patch. Spread distances of more than 10cm are limited to wet peat patches below 160% moisture content (mass of water per mass of dry peat). We found that spatial gradients of moisture content have important local effects on the horizontal spread and should be considered in field and modelling studies. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

Compact beam transport system for free-electron lasers driven by a laser plasma accelerator

DOE PAGES

Liu, Tao; Zhang, Tong; Wang, Dong; ...

2017-02-01

Utilizing laser-driven plasma accelerators (LPAs) as a high-quality electron beam source is a promising approach to significantly downsize the x-ray free-electron laser (XFEL) facility. A multi-GeV LPA beam can be generated in several-centimeter acceleration distance, with a high peak current and a low transverse emittance, which will considerably benefit a compact FEL design. However, the large initial angular divergence and energy spread make it challenging to transport the beam and realize FEL radiation. In this paper, a novel design of beam transport system is proposed to maintain the superior features of the LPA beam and a transverse gradient undulator (TGU)more » is also adopted as an effective energy spread compensator to generate high-brilliance FEL radiation. As a result, theoretical analysis and numerical simulations are presented based on a demonstration experiment with an electron energy of 380 MeV and a radiation wavelength of 30 nm.« less

Characterization of the Hamamatsu 8" R5912-MOD Photomultiplier tube

NASA Astrophysics Data System (ADS)

Kaptanoglu, Tanner

2018-05-01

Current and future neutrino and direct detection dark matter experiments hope to take advantage of improving technologies in photon detection. Many of these detectors are large, monolithic optical detectors that use relatively low-cost, large-area, and efficient photomultiplier tubes (PMTs). A candidate PMT for future experiments is a newly developed prototype Hamamatsu PMT, the R5912-MOD. In this paper we describe measurements made of the single photoelectron time and charge response of the R5912-MOD, as well as detail some direct comparisons to similar PMTs. Most of these measurements were performed on three R5912-MOD PMTs operating at gains close to 1 × 107. The transit time spread (σ) and the charge peak-to-valley were measured to be on average 680ps and 4.2 respectively. The results of this paper show the R5912-MOD is an excellent candidate for future experiments in several regards, particularly due to its narrow spread in timing.

Mechanisms of microgravity flame spread over a thin solid fuel - Oxygen and opposed flow effects

NASA Technical Reports Server (NTRS)

Olson, S. L.

1991-01-01

Microgravity tests varying oxygen concentration and forced flow velocity have examined the importance of transport processes on flame spread over very thin solid fuels. Flame spread rates, solid phase temperature profiles and flame appearance for these tests are measured. A flame spread map is presented which indicates three distinct regions where different mechanisms control the flame spread process. In the near-quenching region (very low characteristic relative velocities) a new controlling mechanism for flame spread - oxidizer transport-limited chemical reaction - is proposed. In the near-limit, blowoff region, high opposed flow velocities impose residence time limitations on the flame spread process. A critical characteristic relative velocity line between the two near-limit regions defines conditions which result in maximum flammability both in terms of a peak flame spread rate and minimum oxygen concentration for steady burning. In the third region, away from both near-limit regions, the flame spread behavior, which can accurately be described by a thermal theory, is controlled by gas-phase conduction.

The memory of the accreting plate boundary and the continuity of fracture zones

USGS Publications Warehouse

Schouten, Hans; Klitgord, Kim D.

1982-01-01

A detailed aeromagnetic anomaly map of the Mesozoic seafloor-spreading lineations southwest of Bermuda reveals the dominant magnetic grain of the oceanic crust and the character of the accreting boundary at the time of crustal formation. The magnetic anomaly pattern is that of a series of elongate lobes perpendicular to the fracture zone (flowline) trends. The linear sets of magnetic anomaly peaks and troughs have narrow regions of reduced amplitude anomalies associated with the fracture zones. During the period of Mesozoic geomagnetic polarity reversals (when 1200 km of central North Atlantic seafloor formed), the Atlantic accreting boundary consisted of stationary, elongate, spreading center cells that maintained their independence even though sometimes only minor spatial offsets existed between cells. Normal oceanic crustal structure was formed in the spreading center cells, but structural anomalies and discontinuities characteristic of fracture zones were formed at their boundaries, which parallel flowlines of Mesozoic relative plate motion in the central North Atlantic. We suggest that the memory for a stationary pattern of independent spreading center cells resides in the young brittle lithosphere at the accreting boundary where the lithosphere is weakest; here, each spreading center cell independently goes through its cylce of stress buildup, stress release, and crustal accretion, after which its memory is refreshed. The temporal offset between the peaks of the accretionary activity that takes place within each cell may provide the mechanism for maintaining the independence of adjacent spreading center cells through times when no spatial offset between the cells exists.

Synthesis and characterization of lead-free tin silver nanosolders and their application to halogen free nanosolder pastes

NASA Astrophysics Data System (ADS)

Wernicki, Evan

Solder paste is a key material used in attaching electronic components to printed circuit boards (PCBs). Commonly used lead-based solders, such as eutectic Sn/37Pb, are currently being replaced by lead-free alloy materials due to health and environmental concerns associated with lead. Many solder pastes, both lead-containing and lead-free, contain halogens which act as activators to remove surface oxide and enhance surface wetting, posing further environmental concern from the halogen species. Difficulties in obtaining reliable joints can occur since lead-free solder material candidates have higher melting temperatures (30-50 °C) than that of lead-based solders. Differences in material properties between the numerous materials used in assembly and packaging processes can lead to component damage during manufacturing. Furthermore, designs that include more electrical interconnects in smaller areas give rise for the need for new materials to allow this trend to continue. A surfactant-assisted chemical reduction method was used to synthesize Sn/Ag alloy nanoparticles with a target composition range of 3.5-5 wt% Ag that served as the lead-free solder material within a nanosolder paste. Structure and size characterization via SEM and TEM showed Sn-Ag nanosolders size average approximately 19 nm. Differential scanning calorimetry (DSC) measurements of the nanosolder samples containing 4.5 wt% Ag showed an endothermic peak at 222.5 °C and an onset of 219.2 °C, indicating up to 17.5 °C melting temperature depression when compared to the bulk liquidus value of 240 °C. Composition of the nanosolder material was confirmed using energy dispersive x-ray spectroscopy (EDS) and structures formed were analyzed via x-ray diffraction (XRD). Both halogen-free and halogen-containing flux materials were combined with the nanosolder material, respectively, with varying preparation parameters to form a design of experiments (DoE) for nanosolder paste preparation. Solder pastes prepared with 55, 70, and 85 wt% nanosolder material have been successfully printed and reflowed on Cu substrates to imitate current manufacturing process. Different peak reflow temperatures of 245 °C and 265 °C were used to observe the effect on solder paste spreading and wetting angle of reflowed solder features. Two different flux chemistries, halogen-free and halogen-based, were also studied. Statistical analysis indicated nanosolder loading had a strong impact on both the wetting angle and paste spreading after the reflow process. The wetting angles of the samples, from the highest to lowest weight percentage, resulted in values of 69.7°, 26.2°, and 0°. A 55 wt% nanosolder paste formed multiple reflowed solder bumps, compared to the single bumps obtained with 70 and 85 wt% nanosolders. The highest loading sample was found to spread the least. This can be attributed to a combination of factors such as higher paste viscosity and lower solder-solder surface tension interactions. A larger peak temperature resulted in larger paste spreading values proving to be significant, however it was not found to affect the resulting wetting angle significantly. Flux chemistry was found to statistically have no profound impact on either the wetting angle or the solder spread. Therefore, it was found that the halogen-free solder paste can act as a suitable replacement for the tested halogen-containing nanosolder paste samples. KEYWORDS : solder paste, nanoparticles, paste printing, lead-free, reflow.

Predicting Peak Flows following Forest Fires

NASA Astrophysics Data System (ADS)

Elliot, William J.; Miller, Mary Ellen; Dobre, Mariana

2016-04-01

Following forest fires, peak flows in perennial and ephemeral streams often increase by a factor of 10 or more. This increase in peak flow rate may overwhelm existing downstream structures, such as road culverts, causing serious damage to road fills at stream crossings. In order to predict peak flow rates following wildfires, we have applied two different tools. One is based on the U.S.D.A Natural Resource Conservation Service Curve Number Method (CN), and the other is by applying the Water Erosion Prediction Project (WEPP) to the watershed. In our presentation, we will describe the science behind the two methods, and present the main variables for each model. We will then provide an example of a comparison of the two methods to a fire-prone watershed upstream of the City of Flagstaff, Arizona, USA, where a fire spread model was applied for current fuel loads, and for likely fuel loads following a fuel reduction treatment. When applying the curve number method, determining the time to peak flow can be problematic for low severity fires because the runoff flow paths are both surface and through shallow lateral flow. The WEPP watershed version incorporates shallow lateral flow into stream channels. However, the version of the WEPP model that was used for this study did not have channel routing capabilities, but rather relied on regression relationships to estimate peak flows from individual hillslope polygon peak runoff rates. We found that the two methods gave similar results if applied correctly, with the WEPP predictions somewhat greater than the CN predictions. Later releases of the WEPP model have incorporated alternative methods for routing peak flows that need to be evaluated.

SU-E-T-161: SOBP Beam Analysis Using Light Output of Scintillation Plate Acquired by CCD Camera.

PubMed

Cho, S; Lee, S; Shin, J; Min, B; Chung, K; Shin, D; Lim, Y; Park, S

2012-06-01

To analyze Bragg-peak beams in SOBP (spread-out Bragg-peak) beam using CCD (charge-coupled device) camera - scintillation screen system. We separated each Bragg-peak beam using light output of high sensitivity scintillation material acquired by CCD camera and compared with Bragg-peak beams calculated by Monte Carlo simulation. In this study, CCD camera - scintillation screen system was constructed with a high sensitivity scintillation plate (Gd2O2S:Tb) and a right-angled prismatic PMMA phantom, and a Marlin F-201B, EEE-1394 CCD camera. SOBP beam irradiated by the double scattering mode of a PROTEUS 235 proton therapy machine in NCC is 8 cm width, 13 g/cm 2 range. The gain, dose rate and current of this beam is 50, 2 Gy/min and 70 nA, respectively. Also, we simulated the light output of scintillation plate for SOBP beam using Geant4 toolkit. We evaluated the light output of high sensitivity scintillation plate according to intergration time (0.1 - 1.0 sec). The images of CCD camera during the shortest intergration time (0.1 sec) were acquired automatically and randomly, respectively. Bragg-peak beams in SOBP beam were analyzed by the acquired images. Then, the SOBP beam used in this study was calculated by Geant4 toolkit and Bragg-peak beams in SOBP beam were obtained by ROOT program. The SOBP beam consists of 13 Bragg-peak beams. The results of experiment were compared with that of simulation. We analyzed Bragg-peak beams in SOBP beam using light output of scintillation plate acquired by CCD camera and compared with that of Geant4 simulation. We are going to study SOBP beam analysis using more effective the image acquisition technique. © 2012 American Association of Physicists in Medicine.

Transient Response in a Dendritic Neuron Model for Current Injected at One Branch

PubMed Central

Rinzel, John; Rall, Wilfrid

1974-01-01

Mathematical expressions are obtained for the response function corresponding to an instantaneous pulse of current injected to a single dendritic branch in a branched dendritic neuron model. The theoretical model assumes passive membrane properties and the equivalent cylinder constraint on branch diameters. The response function when used in a convolution formula enables one to compute the voltage transient at any specified point in the dendritic tree for an arbitrary current injection at a given input location. A particular numerical example, for a brief current injection at a branch terminal, illustrates the attenuation and delay characteristics of the depolarization peak as it spreads throughout the neuron model. In contrast to the severe attenuation of voltage transients from branch input sites to the soma, the fraction of total input charge actually delivered to the soma and other trees is calculated to be about one-half. This fraction is independent of the input time course. Other numerical examples, which compare a branch terminal input site with a soma input site, demonstrate that, for a given transient current injection, the peak depolarization is not proportional to the input resistance at the injection site and, for a given synaptic conductance transient, the effective synaptic driving potential can be significantly reduced, resulting in less synaptic current flow and charge, for a branch input site. Also, for the synaptic case, the two inputs are compared on the basis of the excitatory post-synaptic potential (EPSP) seen at the soma and the total charge delivered to the soma. PMID:4424185

Forecasting the spatial transmission of influenza in the United States.

PubMed

Pei, Sen; Kandula, Sasikiran; Yang, Wan; Shaman, Jeffrey

2018-03-13

Recurrent outbreaks of seasonal and pandemic influenza create a need for forecasts of the geographic spread of this pathogen. Although it is well established that the spatial progression of infection is largely attributable to human mobility, difficulty obtaining real-time information on human movement has limited its incorporation into existing infectious disease forecasting techniques. In this study, we develop and validate an ensemble forecast system for predicting the spatiotemporal spread of influenza that uses readily accessible human mobility data and a metapopulation model. In retrospective state-level forecasts for 35 US states, the system accurately predicts local influenza outbreak onset,-i.e., spatial spread, defined as the week that local incidence increases above a baseline threshold-up to 6 wk in advance of this event. In addition, the metapopulation prediction system forecasts influenza outbreak onset, peak timing, and peak intensity more accurately than isolated location-specific forecasts. The proposed framework could be applied to emergent respiratory viruses and, with appropriate modifications, other infectious diseases.

Improving the spectral resolution and spectral fitting of (1) H MRSI data from human calf muscle by the SPREAD technique.

PubMed

Dong, Zhengchao; Zhang, Yudong; Liu, Feng; Duan, Yunsuo; Kangarlu, Alayar; Peterson, Bradley S

2014-11-01

Proton magnetic resonance spectroscopic imaging ((1) H MRSI) has been used for the in vivo measurement of intramyocellular lipids (IMCLs) in human calf muscle for almost two decades, but the low spectral resolution between extramyocellular lipids (EMCLs) and IMCLs, partially caused by the magnetic field inhomogeneity, has hindered the accuracy of spectral fitting. The purpose of this paper was to enhance the spectral resolution of (1) H MRSI data from human calf muscle using the SPREAD (spectral resolution amelioration by deconvolution) technique and to assess the influence of improved spectral resolution on the accuracy of spectral fitting and on in vivo measurement of IMCLs. We acquired MRI and (1) H MRSI data from calf muscles of three healthy volunteers. We reconstructed spectral lineshapes of the (1) H MRSI data based on field maps and used the lineshapes to deconvolve the measured MRS spectra, thereby eliminating the line broadening caused by field inhomogeneities and improving the spectral resolution of the (1) H MRSI data. We employed Monte Carlo (MC) simulations with 200 noise realizations to measure the variations of spectral fitting parameters and used an F-test to evaluate the significance of the differences of the variations between the spectra before SPREAD and after SPREAD. We also used Cramer-Rao lower bounds (CRLBs) to assess the improvements of spectral fitting after SPREAD. The use of SPREAD enhanced the separation between EMCL and IMCL peaks in (1) H MRSI spectra from human calf muscle. MC simulations and F-tests showed that the use of SPREAD significantly reduced the standard deviations of the estimated IMCL peak areas (p < 10(-8) ), and the CRLBs were strongly reduced (by ~37%). Copyright © 2014 John Wiley & Sons, Ltd.

Optimization of training sequence for DFT-spread DMT signal in optical access network with direct detection utilizing DML.

PubMed

Li, Fan; Li, Xinying; Yu, Jianjun; Chen, Lin

2014-09-22

We experimentally demonstrated the transmission of 79.86-Gb/s discrete-Fourier-transform spread 32 QAM discrete multi-tone (DFT-spread 32 QAM-DMT) signal over 20-km standard single-mode fiber (SSMF) utilizing directly modulated laser (DML). The experimental results show DFT-spread effectively reduces Peak-to-Average Power Ratio (PAPR) of DMT signal, and also well overcomes narrowband interference and high frequencies power attenuation. We compared different types of training sequence (TS) symbols and found that the optimized TS for channel estimation is the symbol with digital BPSK/QPSK modulation format due to its best performance against optical link noise during channel estimation.

SICR rumor spreading model in complex networks: Counterattack and self-resistance

NASA Astrophysics Data System (ADS)

Zan, Yongli; Wu, Jianliang; Li, Ping; Yu, Qinglin

2014-07-01

Rumor is an important form of social interaction. However, spreading of harmful rumors could have a significant negative impact on the well-being of the society. In this paper, considering the counterattack mechanism of the rumor spreading, we introduce two new models: Susceptible-Infective-Counterattack-Refractory (SICR) model and adjusted-SICR model. We then derive mean-field equations to describe their dynamics in homogeneous networks and conduct the steady-state analysis. We also introduce the self-resistance parameter τ, and study the influence of this parameter on rumor spreading. Numerical simulations are performed to compare the SICR model with the SIR model and the adjusted-SICR model, respectively, and we investigate the spreading peak of the rumor and the final size of the rumor with various parameters. Simulation results are congruent exactly with the theoretical analysis. The experiment reveals some interesting patterns of rumor spreading involved with counterattack force.

An analytical and experimental evaluation of a Fresnel lens solar concentrator

NASA Technical Reports Server (NTRS)

Hastings, L. J.; Allums, S. A.; Cosby, R. M.

1976-01-01

An analytical and experimental evaluation of line focusing Fresnel lenses with application potential in the 200 to 370 C range was studied. Analytical techniques were formulated to assess the solar transmission and imaging properties of a grooves down lens. Experimentation was based on a 56 cm wide, f/1.0 lens. A Sun tracking heliostat provided a nonmoving solar source. Measured data indicated more spreading at the profile base than analytically predicted, resulting in a peak concentration 18 percent lower than the computed peak of 57. The measured and computed transmittances were 85 and 87 percent, respectively. Preliminary testing with a subsequent lens indicated that modified manufacturing techniques corrected the profile spreading problem and should enable improved analytical experimental correlation.

The Chemical Composition of NGC 5824, a Globular Cluster without Iron Spread but with an Extreme Mg–Al Anticorrelation

NASA Astrophysics Data System (ADS)

Mucciarelli, Alessio; Lapenna, Emilio; Ferraro, Francesco R.; Lanzoni, Barbara

2018-05-01

NGC 5824 is a massive Galactic globular cluster suspected to have an intrinsic spread in its iron content, according to the strength of the calcium triplet lines. We present chemical abundances of 117 cluster giant stars using high-resolution spectra acquired with the multi-object spectrograph FLAMES. The metallicity distribution of 87 red giant branch stars is peaked at [Fe/H] = ‑2.11 ± 0.01 dex, while that derived from 30 asymptotic giant branch stars is peaked at [Fe/H] = ‑2.20 ± 0.01 dex. Both the distributions are compatible with a null spread, indicating that this cluster did not retain the ejecta of supernovae. The small iron abundance offset between the two groups of stars is similar to the abundances already observed among red and asymptotic giant branch stars in other clusters. The lack of intrinsic iron spread rules out the possibility that NGC 5824 is the remnant of a disrupted dwarf galaxy, as previously suggested. We also find evidence of the chemical anomalies usually observed in globular clusters, namely the Na–O and the Mg–Al anticorrelations. In particular, NGC 5824 exhibits a huge range of [Mg/Fe] abundance, observed in only a few metal-poor and/or massive clusters. We conclude that NGC 5824 is a normal globular cluster, without spread in [Fe/H] but with an unusually large spread in [Mg/Fe], possibly due to an efficient self-enrichment driven by massive asymptotic giant branch stars. Based on observations collected at the ESO-VLT under the program 095.D-0290.

Comparison of nonpolar III-nitride vertical-cavity surface-emitting lasers with tunnel junction and ITO intracavity contacts

NASA Astrophysics Data System (ADS)

Leonard, J. T.; Young, E. C.; Yonkee, B. P.; Cohen, D. A.; Shen, C.; Margalith, T.; Ng, T. K.; DenBaars, S. P.; Ooi, B. S.; Speck, J. S.; Nakamura, S.

2016-02-01

We report on the lasing of III-nitride nonpolar, violet, vertical-cavity surface-emitting lasers (VCSELs) with IIInitride tunnel-junction (TJ) intracavity contacts and ion implanted apertures (IIAs). The TJ VCSELs are compared to similar VCSELs with tin-doped indium oxide (ITO) intracavity contacts. Prior to analyzing device results, we consider the relative advantages of III-nitride TJs for blue and green emitting VCSELs. The TJs are shown to be most advantageous for violet and UV VCSELs, operating near or above the absorption edge for ITO, as they significantly reduce the total internal loss in the cavity. However, for longer wavelength III-nitride VCSELs, TJs primarily offer the advantage of improved cavity design flexibility, allowing one to make the p-side thicker using a thick n-type III-nitride TJ intracavity contact. This offers improved lateral current spreading and lower loss, compare to using ITO and p-GaN, respectively. These aspects are particularly important for achieving high-power CW VCSELs, making TJs the ideal intracavity contact for any III-nitride VCSEL. A brief overview of III-nitride TJ growth methods is also given, highlighting the molecular-beam epitaxy (MBE) technique used here. Following this overview, we compare 12 μm aperture diameter, violet emitting, TJ and ITO VCSEL experimental results, which demonstrate the significant improvement in differential efficiency and peak power resulting from the reduced loss in the TJ design. Specifically, the TJ VCSEL shows a peak power of ~550 μW with a threshold current density of ~3.5 kA/cm2, while the ITO VCSELs show peak powers of ~80 μW and threshold current densities of ~7 kA/cm2.

Symmetric Electrode Spanning Narrows the Excitation Patterns of Partial Tripolar Stimuli in Cochlear Implants.

PubMed

Luo, Xin; Wu, Ching-Chih

2016-12-01

In cochlear implants (CIs), standard partial tripolar (pTP) mode reduces current spread by returning a fraction of the current to two adjacent flanking electrodes within the cochlea. Symmetric electrode spanning (i.e., separating both the apical and basal return electrodes from the main electrode by one electrode) has been shown to increase the pitch of pTP stimuli, when the ratio of intracochlear return current was fixed. To explain the pitch increase caused by symmetric spanning in pTP mode, this study measured the electrical potentials of both standard and symmetrically spanned pTP stimuli on a main electrode EL8 in five CI ears using electrical field imaging (EFI). In addition, the spatial profiles of evoked compound action potentials (ECAP) and the psychophysical forward masking (PFM) patterns were also measured for both stimuli. The EFI, ECAP, and PFM patterns of a given stimulus differed in shape details, reflecting the different levels of auditory processing and different ratios of intracochlear return current across the measurement methods. Compared to the standard pTP stimuli, the symmetrically spanned pTP stimuli significantly reduced the areas under the curves of the normalized EFI and PFM patterns, without shifting the pattern peaks and centroids (both around EL8). The more focused excitation patterns with symmetric spanning may have caused the previously reported pitch increase, due to an interaction between pitch and timbre perception. Being able to reduce the spread of excitation, pTP mode symmetric spanning is a promising stimulation strategy that may further increase spectral resolution and frequency selectivity with CIs.

A proposal for antiparallel acceleration of positrons using CEBAF

NASA Astrophysics Data System (ADS)

Tiefenback, M.; Wojtsekhowski, B.

2018-05-01

We present a scheme for positron beam acceleration in CEBAF antiparallel to the normal electron path, requiring no change in polarity of the magnet systems. This feature is essential to the principal benefit: enabling extremely simple configuration changes between conventional (clockwise) e- acceleration and counter clockwise e+ acceleration. Additionally, it appears possible to configure the accelerating cavity phases to support concurrent acceleration of the electron and positron beams. The last mode also may enable use of the higher peak current electron beam for system diagnostics. The inherent penalty of the concurrent mode in acceleration efficiency and increased energy spread may render this a commissioning-only diagnostic option, but the possibility appears worthy of consideration.

Modeling of divertor power footprint widths on EAST by SOLPS5.0/B2.5-Eirene

NASA Astrophysics Data System (ADS)

Deng, Guozhong; Liu, Xiaoju; Wang, Liang; Liu, Shaocheng; Xu, Jichan; Feng, Wei; Liu, Jianbin; Liu, Huan; Gao, Xiang

2017-04-01

The edge plasma code package SOLPS5.0 is employed to simulate the divertor power footprint widths of the experimental advanced superconducting tokamak (EAST) L-mode and ELM-free H-mode plasmas. The divertor power footprint widths, which consist of the scrape-off layer (SOL) width λ q and heat spreading S, are important physical parameters for edge plasmas. In this work, a plasma current scan is implemented in the simulation to obtain the dependence of the divertor power footprint width on the plasma current I p. Strong inverse scaling of the SOL width with I p has been achieved for both L-mode and H-mode plasmas in the forms of {λ }q,{{L}\\text-\\text{mode}}=4.98× {I}{{p}}-0.68 and {λ }q,{{H}\\text-\\text{mode}}=1.86× {I}{{p}}-1.08. Similar trends have also been demonstrated in the study of heat spreading with {S}{{L}\\text-\\text{mode}}=1.95× {I}{{p}}-0.542 and {S}{{H}\\text-\\text{mode}}=0.756× {I}{{p}}-0.872. In addition, studies on divertor peak heat load and the magnetic flux expansion factor show that both of them are proportional to plasma current. The simulation work here can act as a way to explore the power footprint widths of future tokamak fusion devices such as ITER and the China Fusion Engineering Test Reactor (CFETR).

Acquisition of peak responding: what is learned?

PubMed

Balci, Fuat; Gallistel, Charles R; Allen, Brian D; Frank, Krystal M; Gibson, Jacqueline M; Brunner, Daniela

2009-01-01

We investigated how the common measures of timing performance behaved in the course of training on the peak procedure in C3H mice. Following fixed interval (FI) pre-training, mice received 16 days of training in the peak procedure. The peak time and spread were derived from the average response rates while the start and stop times and their relative variability were derived from a single-trial analysis. Temporal precision (response spread) appeared to improve in the course of training. This apparent improvement in precision was, however, an averaging artifact; it was mediated by the staggered appearance of timed stops, rather than by the delayed occurrence of start times. Trial-by-trial analysis of the stop times for individual subjects revealed that stops appeared abruptly after three to five sessions and their timing did not change as training was prolonged. Start times and the precision of start and stop times were generally stable throughout training. Our results show that subjects do not gradually learn to time their start or stop of responding. Instead, they learn the duration of the FI, with robust temporal control over the start of the response; the control over the stop of response appears abruptly later.

Acquisition of peak responding: What is learned?

PubMed Central

Balci, Fuat; Gallistel, Charles R.; Allen, Brian D.; Frank, Krystal M.; Gibson, Jacqueline M.; Brunner, Daniela

2009-01-01

We investigated how the common measures of timing performance behaved in the course of training on the peak procedure in C3H mice. Following fixed interval (FI) pre-training, mice received 16 days of training in the peak procedure. The peak time and spread were derived from the average response rates while the start and stop times and their relative variability were derived from a single-trial analysis. Temporal precision (response spread) appeared to improve in the course of training. This apparent improvement in precision was, however, an averaging artifact; it was mediated by the staggered appearance of timed stops, rather than by the delayed occurrence of start times. Trial-by-trial analysis of the stop times for individual subjects revealed that stops appeared abruptly after three to five sessions and their timing did not change as training was prolonged. Start times and the precision of start and stop times were generally stable throughout training. Our results show that subjects do not gradually learn to time their start or stop of responding. Instead, they learn the duration of the FI, with robust temporal control over the start of the response; the control over the stop of response appears abruptly later. PMID:18950695

Influence of photo-generated carriers on current spreading in double diode structures for electroluminescent cooling

NASA Astrophysics Data System (ADS)

Radevici, Ivan; Tiira, Jonna; Sadi, Toufik; Oksanen, Jani

2018-05-01

Current crowding close to electrical contacts is a common challenge in all optoelectronic devices containing thin current spreading layers (CSLs). We analyze the effects of current spreading on the operation of the so-called double diode structure (DDS), consisting of a light emitting diode (LED) and a photodiode (PD) fabricated within the same epitaxial growth process, and providing an attractive platform for studying electroluminescent (EL) cooling under high bias conditions. We show that current spreading in the common n-type layer between the LED and the PD can be dramatically improved by the strong optical coupling between the diodes, as the coupling enables a photo-generated current through the PD. This reduces the current in the DDS CSL and enables the study of EL cooling using structures that are not limited by the conventional light extraction challenges encountered in normal LEDs. The current spreading in the structures is studied using optical imaging techniques, electrical measurements, simulations, as well as simple equivalent circuit models developed for this purpose. The improved current spreading leads further to a mutual dependence with the coupling efficiency, which is expected to facilitate the process of optimizing the DDS. We also report a new improved value of 63% for the DDS coupling quantum efficiency.

Efficient quasi-monoenergetic ion beams up to 18 MeV/nucleon via self-generated plasma fields in relativistic laser plasmas

NASA Astrophysics Data System (ADS)

Palaniyappan, Sasi; Huang, Chengkun; Gautier, Donald; Hamilton, Christopher; Santiago, Miguel; Kreuzer, Christian; Shah, Rahul; Fernandez, Juan; Los Alamos National Laboratory Team; Ludwig-Maximilian-University Team

2015-11-01

Table-top laser-plasma ion accelerators seldom achieve narrow energy spreads, and never without serious compromises in efficiency, particle yield, etc. Using massive computer simulations, we identify a self-organizing scheme that exploits persisting self-generated plasma electric (~ TV/m) and magnetic (~ 104 Tesla) fields to reduce the ion energy spread after the laser exits the plasma - separating the ion acceleration from the energy spread reduction. Consistent with the scheme, we experimentally demonstrate aluminum and carbon ion beams with narrow spectral peaks at energies up to 310 MeV (11.5 MeV/nucleon) and 220 MeV (18.3 MeV/nucleon), respectively, with high conversion efficiency (~ 5%, i.e., 4J out of 80J laser). This is achieved with 0.12 PW high-contrast Gaussian laser pulses irradiating planar foils with optimal thicknesses of up to 250 nm that scale with laser intensity. When increasing the focused laser intensity fourfold (by reducing the focusing optic f/number twofold), the spectral-peak energy increases twofold. These results pave the way for next generation compact accelerators suitable for applications. For example, 400 MeV (33.3 MeV/nucleon) carbon-ion beam with narrow energy spread required for ion fast ignition could be generated using PW-class lasers.

LSWS linked with the low-latitude Es and its implications for the growth of the R-T instability

NASA Astrophysics Data System (ADS)

Joshi, L. M.

2016-07-01

A comprehensive investigation of spread F irregularities over the Indian sector has been carried out using VHF radar and ionosonde observations. Two different categories of spread F observations, one where the onset of the range spread F (RSF) was concurrent with the peak h'F (category 1) and another where the RSF onset happened ~90 min after the peak h'F time (category 2), are presented. RSF in category 2 was preceded by the presence of oblique echoes in ionograms, indicating the irregularity genesis westward of Sriharikota. The average peak h'F in category 1 was ~30 km higher than that in category 2 indicating the presence of standing large-scale wave structure (LSWS). Occurrence of the blanketing Es during 19:30 to 20:30 Indian Standard Time in category 1 (category 2) was 0% (>50%). Model computation is also carried out to further substantiate the observational results. Model computation indicates that zonal variation of low-latitude Es can generate zonal modulation in the F layer height rise. It is found that the modulation of the F layer height, linked with the low-latitude Es, assists the equatorial spread F onset by modifying both the growth rate of the collisional Rayleigh-Taylor (R-T) instability and also its efficiency. A predominant presence of low-latitude Es has been observed, but the increase in the F layer height and the R-T instability growth in the evening hours will maximize with complete absence of low-latitude Es. A new mechanism for the generation of LSWS and its implications on R-T instability is discussed.

Measurements of monopolar and bipolar current spreads using forward-masking with a fixed probe.

PubMed

Bingabr, Mohamed G; Espinoza-Varas, Blas; Sigdel, Saroj

2014-05-01

This research employed a forward-masking paradigm to estimate the current spread of monopolar (MP) and bipolar (BP) maskers, with current amplitudes adjusted to elicit the same loudness. Since the spatial separation between active and return electrodes is smaller in BP than in MP configurations, the BP current spread is more localized and presumably superior in terms of speech intelligibility. Because matching the loudness requires higher current in BP than in MP stimulation, previous forward-masking studies show that BP current spread is not consistently narrower across subjects or electrodes within a subject. The present forward-masking measures of current spread differ from those of previous studies by using the same BP probe electrode configuration for both MP and BP masker configurations, and adjusting the current levels of the MP and BP maskers so as to match them in loudness. With this method, the estimate of masker current spread would not be contaminated by differences in probe current spread. Forward masking was studied in four cochlear implant patients, two females and two males, with speech recognition scores higher than 50%; that is, their auditory-nerve survival status was more than adequate to carry out the experiments. The data showed that MP and BP masker configurations produce equivalent masking patterns (and current spreads) in three participants. A fourth participant displayed asymmetrical patterns with enhancement rather than masking in some cases, especially when the probe and masker were at the same location. This study showed equivalent masking patterns for MP and BP maskers when the BP masker current amplitude was increased to match the loudness of the MP masker, and the same BP probe configuration is used with both maskers. This finding could help to explain why cochlear implant users often fail to accrue higher speech intelligibility benefit from BP stimulation.

Oxygen availability and spreading depolarizations provide complementary prognostic information in neuromonitoring of aneurysmal subarachnoid hemorrhage patients.

PubMed

Winkler, Maren Kl; Dengler, Nora; Hecht, Nils; Hartings, Jed A; Kang, Eun J; Major, Sebastian; Martus, Peter; Vajkoczy, Peter; Woitzik, Johannes; Dreier, Jens P

2017-05-01

Multimodal neuromonitoring in neurocritical care increasingly includes electrocorticography to measure epileptic events and spreading depolarizations. Spreading depolarization causes spreading depression of activity (=isoelectricity) in electrically active tissue. If the depression is long-lasting, further spreading depolarizations occur in still isoelectric tissue where no activity can be suppressed. Such spreading depolarizations are termed isoelectric and are assumed to indicate energy compromise. However, experimental and clinical recordings suggest that long-lasting spreading depolarization-induced depression and isoelectric spreading depolarizations are often recorded outside of the actual ischemic zones, allowing the remote diagnosis of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Here, we analyzed simultaneous electrocorticography and tissue partial pressure of oxygen recording in 33 aneurysmal subarachnoid hemorrhage patients. Multiple regression showed that both peak total depression duration per recording day and mean baseline tissue partial pressure of oxygen were independent predictors of outcome. Moreover, tissue partial pressure of oxygen preceding spreading depolarization was similar and differences in tissue partial pressure of oxygen responses to spreading depolarization were only subtle between isoelectric spreading depolarizations and spreading depressions. This further supports that, similar to clustering of spreading depolarizations, long spreading depolarization-induced periods of isoelectricity are useful to detect energy compromise remotely, which is valuable because the exact location of future developing pathology is unknown at the time when the neurosurgeon implants recording devices.

AlGaInP light-emitting diodes with SACNTs as current-spreading layer

PubMed Central

2014-01-01

Transparent conductive current-spreading layer is important for quantum efficiency and thermal performance of light-emitting diodes (LEDs). The increasing demand for tin-doped indium oxide (ITO) caused the price to greatly increase. Super-aligned carbon nanotubes (SACNTs) and Au-coated SACNTs as current-spreading layer were applied on AlGaInP LEDs. The LEDs with Au-coated SACNTs showed good current spreading effect. The voltage bias at 20 mA dropped about 0.15 V, and the optical power increased about 10% compared with the LEDs without SACNTs. PMID:24712527

C/NOFS Satellite Electric Field and Plasma Density Observations of Plasma Instabilities Below the Equatorial F-Peak -- Evidence for Approximately 500 km-Scale Spread-F "Precursor" Waves Driven by Zonal Shear Flow and km-Scale, Narrow-Banded Irregularities

NASA Technical Reports Server (NTRS)

Pfaff, R.; Freudenreich, H.; Klenzing, J.; Liebrecht, C.; Valladares, C.

2011-01-01

As solar activity has increased, the ionosphere F-peak has been elevated on numerous occasions above the C/NOFS satellite perigee of 400km. In particular, during the month of April, 2011, the satellite consistently journeyed below the F-peak whenever the orbit was in the region of the South Atlantic anomaly after sunset. During these passes, data from the electric field and plasma density probes on the satellite have revealed two types of instabilities which had not previously been observed in the C/NOFS data set (to our knowledge): The first is evidence for 400-500km-scale bottomside "undulations" that appear in the density and electric field data. In one case, these large scale waves are associated with a strong shear in the zonal E x B flow, as evidenced by variations in the meridional (outward) electric fields observed above and below the F-peak. These undulations are devoid of smaller scale structures in the early evening, yet appear at later local times along the same orbit associated with fully-developed spread-F with smaller scale structures. This suggests that they may be precursor waves for spread-F, driven by a collisional shear instability, following ideas advanced previously by researchers using data from the Jicamarca radar. A second new result (for C/NOFS) is the appearance of km-scale irregularities that are a common feature in the electric field and plasma density data that also appear when the satellite is below the F -peak at night. The vector electric field instrument on C/NOFS clearly shows that the electric field component of these waves is strongest in the zonal direction. These waves are strongly correlated with simultaneous observations of plasma density oscillations and appear both with, and without, evidence of larger-scale spread-F depletions. These km-scale, quasi-coherent waves strongly resemble the bottomside, sinusoidal irregularities reported in the Atmosphere Explorer satellite data set by Valladares et al. [JGR, 88, 8025, 1983]. We interpret these new observations in terms of fundamental plasma instabilities associated with the unstable, nighttime equatorial ionosphere.

Rapidly moving contact lines and damping contributions

NASA Astrophysics Data System (ADS)

Xia, Yi; Daniel, Susan; Steen, Paul

2017-11-01

Contact angle varies dynamically with contact line (CL) speed when a liquid moves across a solid support, as when a liquid spreads rapidly. For sufficiently rapid spreading, inertia competes with capillarity to influence the interface shape near the support. We use resonant-mode plane-normal support oscillations of droplets to drive lateral contact-line motion. Reynolds numbers based on CL speeds are high and capillary numbers are low. These are inertial-capillary motions. By scanning the driving frequency, we locate the frequency at peak amplification (resonance), obtain the scaled peak height (amplification factor) and a measure of band-width (damping ratio). We report how a parameter for CL mobility depends on these scanning metrics, with the goal of distinguishing contributions from the bulk- and CL-dissipation to overall damping.

Effect of injection-gas concentration on the electron beam quality from a laser-plasma accelerator

NASA Astrophysics Data System (ADS)

Mirzaie, Mohammad; Zhang, Guobo; Li, Song; Gao, Kai; Li, Guangyu; Ain, Quratul; Hafz, Nasr A. M.

2018-04-01

By using 25-45 TW ultra-short (30 fs) laser pulses, we report on the effect of the injection gas concentration on the quality of electron beams generated by a laser-driven plasma wakefield acceleration employing the ionization-injection. For a plasma formed from helium-nitrogen gas mixture and depending on the concentration of the nitrogen gas, we could distinguish a clear trend for the quality of the generated electron beams in terms of their peak energy, energy-spread, divergence angle, and beam charge. The results clearly showed that the lower the nitrogen concentration, the better the quality (higher peak energy, smaller energy spread, and smaller emittance) of the generated electron beams. The results are in reasonable agreement with two-dimensional particle-in-cell simulations.

Topography and tectonics of mid-oceanic ridge axes

NASA Technical Reports Server (NTRS)

Sleep, N. H.; Rosendahl, B. R.

1979-01-01

Numerical fluid dynamic models of mid-oceanic ridge axes were constructed using distributions of material properties constrained by seismic studies and thermal calculations. The calculations indicate that spreading is passive except for forces caused by density differences due to thermal expansion and partial melt. Except for geometric differences due to temperature distribution, one set of mechanical properties can adequately explain central rifts of slow ridges and central peaks of fast ridges. Viscous head loss in the upwelling material dominates at low spreading rates where material ascends through a narrow conduit. Thermal expansion and partial melting dominate at high spreading rates where a wide low viscosity crustal magma chamber is present. The preferred rheology is 10 to the 20th poise for the upwelling lithosphere; less than 5 x 10 to the 17th for the crustal magma chamber and axial intrusion zone at fast ridges, and a yield stress of 200 bars for the lithosphere. The calculation correctly predicts the existence of central peaks at 'hot-spot' ridges, where seismic evidence indicates a large magma chamber.

The role of ITO resistivity on current spreading and leakage in InGaN/GaN light emitting diodes

NASA Astrophysics Data System (ADS)

Sheremet, V.; Genç, M.; Elçi, M.; Sheremet, N.; Aydınlı, A.; Altuntaş, I.; Ding, K.; Avrutin, V.; Özgür, Ü.; Morkoç, H.

2017-11-01

The effect of a transparent ITO current spreading layer on electrical and light output properties of blue InGaN/GaN light emitting diodes (LEDs) is discussed. When finite conductivity of ITO is taken into account, unlike in previous models, the topology of LED die and contacts are shown to significantly affect current spreading and light output characteristics in top emitting devices. We propose an approach for calculating the current transfer length describing current spreading. We show that an inter-digitated electrode configuration with distance between the contact pad and the edge of p-n junction equal to transfer length in the current spreading ITO layer allows one to increase the optical area of LED chip, as compared to the physical area of the die, light output power, and therefore, the LED efficiency for a given current density. A detailed study of unpassivated LEDs also shows that current transfer lengths longer than the distance between the contact pad and the edge of p-n junction leads to increasing surface leakage that can only be remedied with proper passivation.

Spreading Speed of Magnetopause Reconnection X-Lines Using Ground-Satellite Coordination

NASA Astrophysics Data System (ADS)

Zou, Ying; Walsh, Brian M.; Nishimura, Yukitoshi; Angelopoulos, Vassilis; Ruohoniemi, J. Michael; McWilliams, Kathryn A.; Nishitani, Nozomu

2018-01-01

Conceptual and numerical models predict that magnetic reconnection starts at a localized region and then spreads out of the reconnection plane. At the Earth's magnetopause this spreading would occur primarily in local time along the boundary. Different simulations have found the spreading to occur at different speeds such as the Alfvén speed and speed of the current carriers. We use conjugate Time History of Events and Macroscale Interactions during Substorms (THEMIS) spacecraft and Super Dual Auroral Radar Network (SuperDARN) radar measurements to observationally determine the X-line spreading speed at the magnetopause. THEMIS probes the reconnection parameters locally, and SuperDARN tracks the reconnection development remotely. Spreading speeds under different magnetopause boundary conditions are obtained and compared with model predictions. We find that while spreading under weak guide field could be explained by either the current carriers or the Alfvén waves, spreading under strong guide field is consistent only with the current carriers.

Host Immune Responses That Promote Initial HIV Spread

DTIC Science & Technology

2011-07-01

exposure to virus and peak viremia. The vaginal mucosa is the most common site of infection and vaccine strategies focus mainly on promoting...spread to the lymph node specifically in the acute phase, i.e., upon vaginal inoculation. The resulting mathematical model is based on mechanistic...for early immune response to SIV and HIV infection are generally assumed to be similar and are described as follows. Virus enters the vaginal lumen and

Ionosonde observations of daytime spread F at low latitudes

NASA Astrophysics Data System (ADS)

Jiang, Chunhua; Yang, Guobin; Liu, Jing; Yokoyama, Tatsuhiro; Komolmis, Tharadol; Song, Huan; Lan, Ting; Zhou, Chen; Zhang, Yuannong; Zhao, Zhengyu

2016-12-01

Spread F on ionograms has been considered to be a phenomenon mainly occurred at nighttime. This study presented a case study of daytime spread F observed by the ionosonde installed at Puer (PUR; 22.7°N, 101.05°E; dip latitude 12.9°N), where daytime spread F that lasted for more than 2 h (about 08:30 LT 10:45 LT) was observed on 14 November 2015. To investigate the possible mechanism, ionograms recorded at PUR and Chiang Mai (18.76°N, 98.93°E; dip latitude 9.04°N) were used in this study. We found that traveling ionospheric disturbances were observed before the occurrence of daytime spread F. Meanwhile, the movement of the peak height of the ionosphere was downward. We suggested that downward vertical neutral winds excited by traveling atmospheric disturbances/atmospheric gravity waves might play a significant role in forming daytime spread F over PUR during geomagnetic storms.

Three-dimensional modeling of plasma edge transport and divertor fluxes during application of resonant magnetic perturbations on ITER

NASA Astrophysics Data System (ADS)

Schmitz, O.; Becoulet, M.; Cahyna, P.; Evans, T. E.; Feng, Y.; Frerichs, H.; Loarte, A.; Pitts, R. A.; Reiser, D.; Fenstermacher, M. E.; Harting, D.; Kirschner, A.; Kukushkin, A.; Lunt, T.; Saibene, G.; Reiter, D.; Samm, U.; Wiesen, S.

2016-06-01

Results from three-dimensional modeling of plasma edge transport and plasma-wall interactions during application of resonant magnetic perturbation (RMP) fields for control of edge-localized modes in the ITER standard 15 MA Q  =  10 H-mode are presented. The full 3D plasma fluid and kinetic neutral transport code EMC3-EIRENE is used for the modeling. Four characteristic perturbed magnetic topologies are considered and discussed with reference to the axisymmetric case without RMP fields. Two perturbation field amplitudes at full and half of the ITER ELM control coil current capability using the vacuum approximation are compared to a case including a strongly screening plasma response. In addition, a vacuum field case at high q 95  =  4.2 featuring increased magnetic shear has been modeled. Formation of a three-dimensional plasma boundary is seen for all four perturbed magnetic topologies. The resonant field amplitudes and the effective radial magnetic field at the separatrix define the shape and extension of the 3D plasma boundary. Opening of the magnetic field lines from inside the separatrix establishes scrape-off layer-like channels of direct parallel particle and heat flux towards the divertor yielding a reduction of the main plasma thermal and particle confinement. This impact on confinement is most accentuated at full RMP current and is strongly reduced when screened RMP fields are considered, as well as for the reduced coil current cases. The divertor fluxes are redirected into a three-dimensional pattern of helical magnetic footprints on the divertor target tiles. At maximum perturbation strength, these fingers stretch out as far as 60 cm across the divertor targets, yielding heat flux spreading and the reduction of peak heat fluxes by 30%. However, at the same time substantial and highly localized heat fluxes reach divertor areas well outside of the axisymmetric heat flux decay profile. Reduced RMP amplitudes due to screening or reduced RMP coil current yield a reduction of the width of the divertor flux spreading to about 20-25 cm and cause increased peak heat fluxes back to values similar to those in the axisymmetric case. The dependencies of these features on the divertor recycling regime and the perpendicular transport assumptions, as well as toroidal averaged effects mimicking rotation of the RMP field, are discussed in the paper.

High quality ultrafast transmission electron microscopy using resonant microwave cavities.

PubMed

Verhoeven, W; van Rens, J F M; Kieft, E R; Mutsaers, P H A; Luiten, O J

2018-05-01

Ultrashort, low-emittance electron pulses can be created at a high repetition rate by using a TM 110 deflection cavity to sweep a continuous beam across an aperture. These pulses can be used for time-resolved electron microscopy with atomic spatial and temporal resolution at relatively large average currents. In order to demonstrate this, a cavity has been inserted in a transmission electron microscope, and picosecond pulses have been created. No significant increase of either emittance or energy spread has been measured for these pulses. At a peak current of 814 ± 2 pA, the root-mean-square transverse normalized emittance of the electron pulses is ɛ n,x =(2.7±0.1)·10 -12  m rad in the direction parallel to the streak of the cavity, and ɛ n,y =(2.5±0.1)·10 -12  m rad in the perpendicular direction for pulses with a pulse length of 1.1-1.3 ps. Under the same conditions, the emittance of the continuous beam is ɛ n,x =ɛ n,y =(2.5±0.1)·10 -12  m rad. Furthermore, for both the pulsed and the continuous beam a full width at half maximum energy spread of 0.95 ± 0.05 eV has been measured. Copyright © 2018 Elsevier B.V. All rights reserved.

Depth Dose Measurement using a Scintillating Fiber Optic Dosimeter for Proton Therapy Beam of the Passive-Scattering Mode Having Range Modulator Wheel

NASA Astrophysics Data System (ADS)

Hwang, Ui-Jung; Shin, Dongho; Lee, Se Byeong; Lim, Young Kyung; Jeong, Jong Hwi; Kim, Hak Soo; Kim, Ki Hwan

2018-05-01

To apply a scintillating fiber dosimetry system to measure the range of a proton therapy beam, a new method was proposed to correct for the quenching effect on measuring an spread out Bragg peak (SOBP) proton beam whose range is modulated by a range modulator wheel. The scintillating fiber dosimetry system was composed of a plastic scintillating fiber (BCF-12), optical fiber (SH 2001), photo multiplier tube (H7546), and data acquisition system (PXI6221 and SCC68). The proton beam was generated by a cyclotron (Proteus-235) in the National Cancer Center in Korea. It operated in the double-scattering mode and the spread out of the Bragg peak was achieved by a spinning range modulation wheel. Bragg peak beams and SOBP beams of various ranges were measured, corrected, and compared to the ion chamber data. For the Bragg peak beam, quenching equation was used to correct the quenching effect. On the proposed process of correcting SOBP beams, the measured data using a scintillating fiber were separated by the Bragg peaks that the SOBP beam contained, and then recomposed again to reconstruct an SOBP after correcting for each Bragg peak. The measured depth-dose curve for the single Bragg peak beam was well corrected by using a simple quenching equation. Correction for SOBP beam was conducted with a newly proposed method. The corrected SOBP signal was in accordance with the results measured with an ion chamber. We propose a new method to correct for the SOBP beam from the quenching effect in a scintillating fiber dosimetry system. This method can be applied to other scintillator dosimetry for radiation beams in which the quenching effect is shown in the scintillator.

Disparities in spread and control of influenza in slums of Delhi: findings from an agent-based modelling study

PubMed Central

Adiga, Abhijin; Chu, Shuyu; Eubank, Stephen; Kuhlman, Christopher J; Lewis, Bryan; Marathe, Achla; Marathe, Madhav; Nordberg, Eric K; Swarup, Samarth; Vullikanti, Anil; Wilson, Mandy L

2018-01-01

Objectives This research studies the role of slums in the spread and control of infectious diseases in the National Capital Territory of India, Delhi, using detailed social contact networks of its residents. Methods We use an agent-based model to study the spread of influenza in Delhi through person-to-person contact. Two different networks are used: one in which slum and non-slum regions are treated the same, and the other in which 298 slum zones are identified. In the second network, slum-specific demographics and activities are assigned to the individuals whose homes reside inside these zones. The main effects of integrating slums are that the network has more home-related contacts due to larger family sizes and more outside contacts due to more daily activities outside home. Various vaccination and social distancing interventions are applied to control the spread of influenza. Results Simulation-based results show that when slum attributes are ignored, the effectiveness of vaccination can be overestimated by 30%–55%, in terms of reducing the peak number of infections and the size of the epidemic, and in delaying the time to peak infection. The slum population sustains greater infection rates under all intervention scenarios in the network that treats slums differently. Vaccination strategy performs better than social distancing strategies in slums. Conclusions Unique characteristics of slums play a significant role in the spread of infectious diseases. Modelling slums and estimating their impact on epidemics will help policy makers and regulators more accurately prioritise allocation of scarce medical resources and implement public health policies. PMID:29358419

A proposal for antiparallel acceleration of positrons using CEBAF

DOE PAGES

Tiefenback, M.; Wojtsekhowski, B.

2018-05-01

Here, we present a scheme for positron beam acceleration in CEBAF antiparallel to the normal electron path, requiring no change in polarity of the magnet systems. This feature is essential to the principal benefit: enabling extremely simple configuration changes between conventional (clockwise) e - acceleration and counter clockwise e + acceleration. Additionally, it appears possible to configure the accelerating cavity phases to support concurrent acceleration of the electron and positron beams. The last mode also may enable use of the higher peak current electron beam for system diagnostics. The inherent penalty of the concurrent mode in acceleration efficiency and increasedmore » energy spread may render this a commissioning-only diagnostic option, but the possibility appears worthy of consideration.« less

A proposal for antiparallel acceleration of positrons using CEBAF

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tiefenback, M.; Wojtsekhowski, B.

Here, we present a scheme for positron beam acceleration in CEBAF antiparallel to the normal electron path, requiring no change in polarity of the magnet systems. This feature is essential to the principal benefit: enabling extremely simple configuration changes between conventional (clockwise) e - acceleration and counter clockwise e + acceleration. Additionally, it appears possible to configure the accelerating cavity phases to support concurrent acceleration of the electron and positron beams. The last mode also may enable use of the higher peak current electron beam for system diagnostics. The inherent penalty of the concurrent mode in acceleration efficiency and increasedmore » energy spread may render this a commissioning-only diagnostic option, but the possibility appears worthy of consideration.« less

TU-H-CAMPUS-TeP3-03: Dose Enhancement by Gold Nanoparticles Around the Bragg Peak of Proton Beams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kwon, J; Sutherland, K; Hashimoto, T

2016-06-15

Purpose: To make clear the spatial distribution of dose enhancement around gold nanoparticles (GNPs) located near the proton Bragg peak, and to evaluate the potential of GNPs as a radio sensitizer. Methods: The dose enhancement by electrons emitted from GNPs under proton irradiation was estimated by Geant4 Monte Carlo simulation toolkit in two steps. In an initial macroscopic step, 100 and 195 MeV proton beams were incident on a water cube, 30 cm on a side. Energy distributions of protons were calculated at four depths, 50% and 75% proximal to the Bragg peak, 100% peak, and 75% distal to themore » peak (P50, P75, Peak, and D75, respectively). In a subsequent microscopic step, protons with the energy distribution calculated above were incident on a 20 nm diameter GNP in a nanometer-size water box and the spatial distribution of dose around the GNP was determined for each energy distribution. The dose enhancement factor (DEF) was also deduced. Results: The dose enhancement effect was spread to several tens of nanometers in the both depth and radial directions. The enhancement area increased in the order of P50, P75, Peak, and D75 for both cases with 100 and 195 MeV protons. In every position around the Bragg peak, the 100 MeV beam resulted in a higher dose enhancement than the 195 MeV beam. At P75, the average and maximum DEF were 3.9 and 17.0 for 100 MeV, and 3.5 and 16.2 for 195 MeV, respectively. These results indicate that lower energy protons caused higher dose enhancement in this incident proton energy range. Conclusion: The dose enhancement around GNPs spread as the position in the Bragg peak region becomes deeper and depends on proton energy. It is expected that GNPs can be used as a radio sensitizer with consideration of the location and proton beam energy.« less

Comparison of dissimilarity measures for cluster analysis of X-ray diffraction data from combinatorial libraries

NASA Astrophysics Data System (ADS)

Iwasaki, Yuma; Kusne, A. Gilad; Takeuchi, Ichiro

2017-12-01

Machine learning techniques have proven invaluable to manage the ever growing volume of materials research data produced as developments continue in high-throughput materials simulation, fabrication, and characterization. In particular, machine learning techniques have been demonstrated for their utility in rapidly and automatically identifying potential composition-phase maps from structural data characterization of composition spread libraries, enabling rapid materials fabrication-structure-property analysis and functional materials discovery. A key issue in development of an automated phase-diagram determination method is the choice of dissimilarity measure, or kernel function. The desired measure reduces the impact of confounding structural data issues on analysis performance. The issues include peak height changes and peak shifting due to lattice constant change as a function of composition. In this work, we investigate the choice of dissimilarity measure in X-ray diffraction-based structure analysis and the choice of measure's performance impact on automatic composition-phase map determination. Nine dissimilarity measures are investigated for their impact in analyzing X-ray diffraction patterns for a Fe-Co-Ni ternary alloy composition spread. The cosine, Pearson correlation coefficient, and Jensen-Shannon divergence measures are shown to provide the best performance in the presence of peak height change and peak shifting (due to lattice constant change) when the magnitude of peak shifting is unknown. With prior knowledge of the maximum peak shifting, dynamic time warping in a normalized constrained mode provides the best performance. This work also serves to demonstrate a strategy for rapid analysis of a large number of X-ray diffraction patterns in general beyond data from combinatorial libraries.

The rise of methamphetamine in Southeast and East Asia.

PubMed

McKetin, Rebecca; Kozel, Nicholas; Douglas, Jeremy; Ali, Robert; Vicknasingam, Balasingam; Lund, Johannes; Li, Jih-Heng

2008-05-01

Southeast and East Asia has become a global hub for methamphetamine production and trafficking over the past decade. This paper describes the rise of methamphetamine supply and to what extent use of the drug is occurring in the region. The current review uses data collected through the Drug Abuse Information Network for Asia and the Pacific (DAINAP) and other available sources to analyse retrospectively methamphetamine trends within Southeast and East Asia. Southeast and East Asia has experienced a methamphetamine epidemic in the past decade which began around 1997 and peaked in 2000-2001. While the situation has since stabilised in many countries, methamphetamine trafficking and use are still increasing in parts of the Mekong region and there is evidence of large-scale manufacture in Cambodia, Indonesia, Malaysia and the Philippines. Methamphetamine is typically smoked or ingested, but injection of the drug is apparent. While the peak of the methamphetamine epidemic has passed in parts of Southeast and East Asia, attention is needed to minimise the potential consequences of spreading methamphetamine production, trafficking and use in the Mekong region and in the peninsular and archipelago of Southeast Asia.

Myxomatosis: population dynamics of rabbits (Oryctolagus cuniculus Linnaeus, 1758) and ecological effects in the United Kingdom.

PubMed

Flowerdew, J R; Trout, R C; Ross, J

1992-12-01

In 1953-1955, myxomatosis spread among rabbits (Oryctolagus cuniculus) in the United Kingdom, causing 99% mortality. Subsequently, there was a gradual increase in rabbit numbers. By 1955, the Ministry of Agriculture, Fisheries and Food (MAFF) had already found attenuated strains of myxoma virus. By 1970, genetic resistance had appeared. In the 1970s, mortality declined to 47-69% with only approximately 25% of rabbits infected, giving a field mortality of 12-19%. However, myxomatosis is persistent, generally showing a major prevalence peak in autumn and often a minor peak in spring. An eight-year MAFF experiment in which prevalence of the disease was artificially reduced indicates that myxomatosis remains a significant factor in population regulation. After rabbit numbers fell in the 1950s, important ecological changes took place: vegetation altered due to reduced grazing pressure, predators were affected by the reduction of a major prey species and these changes also affected many other animals. Currently, rabbit numbers have returned to approximately one-third of pre-myxomatosis levels and this is causing damage to farm and conservation habitats.

Liquefaction at Oceano, California, during the 2003 San Simeon earthquake

USGS Publications Warehouse

Holzer, T.L.; Noce, T.E.; Bennett, M.J.; Tinsley, J. C.; Rosenberg, L.I.

2005-01-01

The 2003 M 6.5 San Simeon, California, earthquake caused liquefaction-induced lateral spreading at Oceano at an unexpectedly large distance from the seismogenic rupture. We conclude that the liquefaction was caused by ground motion that was enhanced by both rupture directivity in the mainshock and local site amplification by unconsolidated fine-grained deposits. Liquefaction occurred in sandy artificial fill and undisturbed eolian sand and fluvial deposits. The largest and most damaging lateral spread was caused by liquefaction of artificial fill; the head of this lateral spread coincided with the boundary between the artificial fill and undisturbed eolian sand deposits. Values of the liquefaction potential index, in general, were greater than 5 at liquefaction sites, the threshold value that has been proposed for liquefaction hazard mapping. Although the mainshock ground motion at Oceano was not recorded, peak ground acceleration was estimated to range from 0.25 and 0.28g on the basis of the liquefaction potential index and aftershock recordings. The estimates fall within the range of peak ground acceleration values associated with the modified Mercalli intensity = VII reported at the U.S. Geological Survey (USGS) "Did You Feel It?" web site.

Generation of narrow energy spread ion beams via collisionless shock waves using ultra-intense 1 um wavelength laser systems

NASA Astrophysics Data System (ADS)

Albert, Felicie; Pak, A.; Kerr, S.; Lemos, N.; Link, A.; Patel, P.; Pollock, B. B.; Haberberger, D.; Froula, D.; Gauthier, M.; Glenzer, S. H.; Longman, A.; Manzoor, L.; Fedosejevs, R.; Tochitsky, S.; Joshi, C.; Fiuza, F.

2017-10-01

In this work, we report on electrostatic collisionless shock wave acceleration experiments that produced proton beams with peak energies between 10-17.5 MeV, with narrow energy spreads between Δ E / E of 10-20%, and with a total number of protons in these peaks of 1e7-1e8. These beams of ions were created by driving an electrostatic collisionless shock wave in a tailored near critical density plasma target using the ultra-intense ps duration Titan laser that operates at a wavelength of 1 um. The near critical density target was produced through the ablation of an initially 0.5 um thick Mylar foil with a separate low intensity laser. A narrow energy spread distribution of carbon / oxygen ions with a similar velocity to the accelerated proton distribution, consistent with the reflection and acceleration of ions from an electrostatic field, was also observed. This work was supported by Lawrence Livermore National Laboratory's Laboratory Directed Research and Development program under project 15-LW-095, and the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA2734.

Single-Crystalline, Nanoporous Gallium Nitride Films With Fine Tuning of Pore Size for Stem Cell Engineering.

PubMed

Han, Lin; Zhou, Jing; Sun, Yubing; Zhang, Yu; Han, Jung; Fu, Jianping; Fan, Rong

2014-11-01

Single-crystalline nanoporous gallium nitride (GaN) thin films were fabricated with the pore size readily tunable in 20-100 nm. Uniform adhesion and spreading of human mesenchymal stem cells (hMSCs) seeded on these thin films peak on the surface with pore size of 30 nm. Substantial cell elongation emerges as pore size increases to ∼80 nm. The osteogenic differentiation of hMSCs occurs preferentially on the films with 30 nm sized nanopores, which is correlated with the optimum condition for cell spreading, which suggests that adhesion, spreading, and stem cell differentiation are interlinked and might be coregulated by nanotopography.

Real-time quantification of emissions of volatile organic compounds from land spreading of pig slurry measured by PTR-MS and wind tunnels.

PubMed

Liu, Dezhao; Nyord, Tavs; Rong, Li; Feilberg, Anders

2018-10-15

Volatile organic compounds (VOC) and hydrogen sulfide are emitted from land spreading of manure slurry to the atmosphere and contribute to odour nuisance, particle formation and tropospheric ozone formation. Data on emissions is almost non-existing partly due to lack of suitable quantitative methods for measuring emissions in full scale. Here we present a method based on application of wind tunnels for simulation of air exchange combined with the use of online mass spectrometry (PTR-MS). The focus was on odorous VOC but all relevant VOC were included. A method for quantification of VOC emission based on calculated proton-transfer reaction rate constants was validated by comparison to reference concentrations for typical VOC emitted from pig manure slurry. Wall losses of volatile sulfur compounds in the wind tunnels were assessed to be insignificant and recoveries >95% were observed for these compounds. An influence of air exchange rate was clearly observed highlighting the need to identify realistic air exchange rates for future application of the method. Emission data was obtained for spreading of pig manure slurry as an example of an important source of gases. Emissions were monitored for ~37 h following land spreading and time-resolved emission data was presented for the first time. Highest emissions were observed for short-chain volatile carboxylic acids (C 2 -C 6 ) with acetic acid being the most abundant compound. Emission peaks were observed immediately following application and were followed by declining emissions until the second day at which emissions reached a second peak for several compounds. This second emission peak was speculated to be caused by a temperature-induced diurnal effect. Emissions of volatile sulfur compounds occurred on a short time-scale and ceased shortly after application. Odour activity values were dominated by C 4 -C 5 carboxylic acids and 4-methylphenol with a less pronounced influence of 4-methylphenol on day 2. Copyright © 2018 Elsevier B.V. All rights reserved.

Creating nanoscale emulsions using condensation.

PubMed

Guha, Ingrid F; Anand, Sushant; Varanasi, Kripa K

2017-11-08

Nanoscale emulsions are essential components in numerous products, ranging from processed foods to novel drug delivery systems. Existing emulsification methods rely either on the breakup of larger droplets or solvent exchange/inversion. Here we report a simple, scalable method of creating nanoscale water-in-oil emulsions by condensing water vapor onto a subcooled oil-surfactant solution. Our technique enables a bottom-up approach to forming small-scale emulsions. Nanoscale water droplets nucleate at the oil/air interface and spontaneously disperse within the oil, due to the spreading dynamics of oil on water. Oil-soluble surfactants stabilize the resulting emulsions. We find that the oil-surfactant concentration controls the spreading behavior of oil on water, as well as the peak size, polydispersity, and stability of the resulting emulsions. Using condensation, we form emulsions with peak radii around 100 nm and polydispersities around 10%. This emulsion formation technique may open different routes to creating emulsions, colloidal systems, and emulsion-based materials.

An analytical reconstruction model of the spread-out Bragg peak using laser-accelerated proton beams.

PubMed

Tao, Li; Zhu, Kun; Zhu, Jungao; Xu, Xiaohan; Lin, Chen; Ma, Wenjun; Lu, Haiyang; Zhao, Yanying; Lu, Yuanrong; Chen, Jia-Er; Yan, Xueqing

2017-07-07

With the development of laser technology, laser-driven proton acceleration provides a new method for proton tumor therapy. However, it has not been applied in practice because of the wide and decreasing energy spectrum of laser-accelerated proton beams. In this paper, we propose an analytical model to reconstruct the spread-out Bragg peak (SOBP) using laser-accelerated proton beams. Firstly, we present a modified weighting formula for protons of different energies. Secondly, a theoretical model for the reconstruction of SOBPs with laser-accelerated proton beams has been built. It can quickly calculate the number of laser shots needed for each energy interval of the laser-accelerated protons. Finally, we show the 2D reconstruction results of SOBPs for laser-accelerated proton beams and the ideal situation. The final results show that our analytical model can give an SOBP reconstruction scheme that can be used for actual tumor therapy.

Experimental investigation of large-scale vortices in a freely spreading gravity current

NASA Astrophysics Data System (ADS)

Yuan, Yeping; Horner-Devine, Alexander R.

2017-10-01

A series of laboratory experiments are presented to compare the dynamics of constant-source buoyant gravity currents propagating into laterally confined (channelized) and unconfined (spreading) environments. The plan-form structure of the spreading current and the vertical density and velocity structures on the interface are quantified using the optical thickness method and a combined particle image velocimetry and planar laser-induced fluorescence method, respectively. With lateral boundaries, the buoyant current thickness is approximately constant and Kelvin-Helmholtz instabilities are generated within the shear layer. The buoyant current structure is significantly different in the spreading case. As the current spreads laterally, nonlinear large-scale vortex structures are observed at the interface, which maintain a coherent shape as they propagate away from the source. These structures are continuously generated near the river mouth, have amplitudes close to the buoyant layer thickness, and propagate offshore at speeds approximately equal to the internal wave speed. The observed depth and propagation speed of the instabilities match well with the fastest growing mode predicted by linear stability analysis, but with a shorter wavelength. The spreading flows have much higher vorticity, which is aggregated within the large-scale structures. Secondary instabilities are generated on the leading edge of the braids between the large-scale vortex structures and ultimately break and mix on the lee side of the structures. Analysis of the vortex dynamics shows that lateral stretching intensifies the vorticity in the spreading currents, contributing to higher vorticity within the large-scale structures in the buoyant plume. The large-scale instabilities and vortex structures observed in the present study provide new insights into the origin of internal frontal structures frequently observed in coastal river plumes.

Spatial spread of the West Africa Ebola epidemic.

PubMed

Kramer, Andrew M; Pulliam, J Tomlin; Alexander, Laura W; Park, Andrew W; Rohani, Pejman; Drake, John M

2016-08-01

Controlling Ebola outbreaks and planning an effective response to future emerging diseases are enhanced by understanding the role of geography in transmission. Here we show how epidemic expansion may be predicted by evaluating the relative probability of alternative epidemic paths. We compared multiple candidate models to characterize the spatial network over which the 2013-2015 West Africa epidemic of Ebola virus spread and estimate the effects of geographical covariates on transmission during peak spread. The best model was a generalized gravity model where the probability of transmission between locations depended on distance, population density and international border closures between Guinea, Liberia and Sierra Leone and neighbouring countries. This model out-performed alternative models based on diffusive spread, the force of infection, mobility estimated from cell phone records and other hypothesized patterns of spread. These findings highlight the importance of integrated geography to epidemic expansion and may contribute to identifying both the most vulnerable unaffected areas and locations of maximum intervention value.

Spatial spread of the West Africa Ebola epidemic

PubMed Central

Pulliam, J. Tomlin; Alexander, Laura W.; Rohani, Pejman; Drake, John M.

2016-01-01

Controlling Ebola outbreaks and planning an effective response to future emerging diseases are enhanced by understanding the role of geography in transmission. Here we show how epidemic expansion may be predicted by evaluating the relative probability of alternative epidemic paths. We compared multiple candidate models to characterize the spatial network over which the 2013–2015 West Africa epidemic of Ebola virus spread and estimate the effects of geographical covariates on transmission during peak spread. The best model was a generalized gravity model where the probability of transmission between locations depended on distance, population density and international border closures between Guinea, Liberia and Sierra Leone and neighbouring countries. This model out-performed alternative models based on diffusive spread, the force of infection, mobility estimated from cell phone records and other hypothesized patterns of spread. These findings highlight the importance of integrated geography to epidemic expansion and may contribute to identifying both the most vulnerable unaffected areas and locations of maximum intervention value. PMID:27853607

Aquarius and SMOS detect effects of an extreme Mississippi River flooding event in the Gulf of Mexico

NASA Astrophysics Data System (ADS)

Gierach, Michelle M.; Vazquez-Cuervo, Jorge; Lee, Tong; Tsontos, Vardis M.

2013-10-01

surface salinity (SSS) measurements from the Aquarius/Satélite de Aplicaciones Científicas (SAC)-D satellite and Soil Moisture and Ocean Salinity (SMOS) mission were used to document the freshening associated with the record 2011 Mississippi River flooding event in the Gulf of Mexico (GoM). Assessment of the salinity response was aided by additional satellite observations, including chlorophyll-a (chl-a) and ocean surface currents, and a passive tracer simulation. Low SSS values associated with the spreading of the river plume were observed 1-3 months after peak river discharge which then receded and became unidentifiable from satellite observations 5 months after maximum discharge. The seasonal wind pattern and general circulation of the GoM dramatically impacted the observed salinity response, transporting freshwater eastward along the Gulf coast and entraining low salinity waters into the open GoM. The observed salinity response from Aquarius was consistent with SMOS SSS, chl-a concentrations, and the passive tracer simulation in terms of the pathway and transit time of the river plume spreading. This study is the first successful application of satellite SSS to study salinity variation in marginal seas.

Disparities in spread and control of influenza in slums of Delhi: findings from an agent-based modelling study.

PubMed

Adiga, Abhijin; Chu, Shuyu; Eubank, Stephen; Kuhlman, Christopher J; Lewis, Bryan; Marathe, Achla; Marathe, Madhav; Nordberg, Eric K; Swarup, Samarth; Vullikanti, Anil; Wilson, Mandy L

2018-01-21

This research studies the role of slums in the spread and control of infectious diseases in the National Capital Territory of India, Delhi, using detailed social contact networks of its residents. We use an agent-based model to study the spread of influenza in Delhi through person-to-person contact. Two different networks are used: one in which slum and non-slum regions are treated the same, and the other in which 298 slum zones are identified. In the second network, slum-specific demographics and activities are assigned to the individuals whose homes reside inside these zones. The main effects of integrating slums are that the network has more home-related contacts due to larger family sizes and more outside contacts due to more daily activities outside home. Various vaccination and social distancing interventions are applied to control the spread of influenza. Simulation-based results show that when slum attributes are ignored, the effectiveness of vaccination can be overestimated by 30%-55%, in terms of reducing the peak number of infections and the size of the epidemic, and in delaying the time to peak infection. The slum population sustains greater infection rates under all intervention scenarios in the network that treats slums differently. Vaccination strategy performs better than social distancing strategies in slums. Unique characteristics of slums play a significant role in the spread of infectious diseases. Modelling slums and estimating their impact on epidemics will help policy makers and regulators more accurately prioritise allocation of scarce medical resources and implement public health policies. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Method and apparatus for current-output peak detection

DOE Office of Scientific and Technical Information (OSTI.GOV)

De Geronimo, Gianluigi

2017-01-24

A method and apparatus for a current-output peak detector. A current-output peak detector circuit is disclosed and works in two phases. The peak detector circuit includes switches to switch the peak detector circuit from the first phase to the second phase upon detection of the peak voltage of an input voltage signal. The peak detector generates a current output with a high degree of accuracy in the second phase.

Graphene interlayer for current spreading enhancement by engineering of barrier height in GaN-based light-emitting diodes.

PubMed

Min, Jung-Hong; Son, Myungwoo; Bae, Si-Young; Lee, Jun-Yeob; Yun, Joosun; Maeng, Min-Jae; Kwon, Dae-Gyeon; Park, Yongsup; Shim, Jong-In; Ham, Moon-Ho; Lee, Dong-Seon

2014-06-30

Pristine graphene and a graphene interlayer inserted between indium tin oxide (ITO) and p-GaN have been analyzed and compared with ITO, which is a typical current spreading layer in lateral GaN LEDs. Beyond a certain current injection, the pristine graphene current spreading layer (CSL) malfunctioned due to Joule heat that originated from the high sheet resistance and low work function of the CSL. However, by combining the graphene and the ITO to improve the sheet resistance, it was found to be possible to solve the malfunctioning phenomenon. Moreover, the light output power of an LED with a graphene interlayer was stronger than that of an LED using ITO or graphene CSL. We were able to identify that the improvement originated from the enhanced current spreading by inspecting the contact and conducting the simulation.

Peak horizontal acceleration and velocity from strong-motion records including records from the 1979 imperial valley, California, earthquake

USGS Publications Warehouse

Joyner, William B.; Boore, David M.

1981-01-01

We have taken advantage of the recent increase in strong-motion data at close distances to derive new attenuation relations for peak horizontal acceleration and velocity. This new analysis uses a magnitude-independent shape, based on geometrical spreading and anelastic attenuation, for the attenuation curve. An innovation in technique is introduced that decouples the determination of the distance dependence of the data from the magnitude dependence.

Nanoscale Electronic Conditioning for Improvement of Nanowire Light-Emitting-Diode Efficiency.

PubMed

May, Brelon J; Belz, Matthew R; Ahamed, Arshad; Sarwar, A T M G; Selcu, Camelia M; Myers, Roberto C

2018-04-24

Commercial III-Nitride LEDs and lasers spanning visible and ultraviolet wavelengths are based on epitaxial films. Alternatively, nanowire-based III-Nitride optoelectronics offer the advantage of strain compliance and high crystalline quality growth on a variety of inexpensive substrates. However, nanowire LEDs exhibit an inherent property distribution, resulting in uneven current spreading through macroscopic devices that consist of millions of individual nanowire diodes connected in parallel. Despite being electrically connected, only a small fraction of nanowires, sometimes <1%, contribute to the electroluminescence (EL). Here, we show that a population of electrical shorts exists in the devices, consisting of a subset of low-resistance nanowires that pass a large portion of the total current in the ensemble devices. Burn-in electronic conditioning is performed by applying a short-term overload voltage; the nanoshorts experience very high current density, sufficient to render them open circuits, thereby forcing a new current path through more nanowire LEDs in an ensemble device. Current-voltage measurements of individual nanowires are acquired using conductive atomic force microscopy to observe the removal of nanoshorts using burn-in. In macroscopic devices, this results in a 33× increase in peak EL and reduced leakage current. Burn-in conditioning of nanowire ensembles therefore provides a straightforward method to mitigate nonuniformities inherent to nanowire devices.

Current responsive devices for synchronous generators

DOEpatents

Karlicek, Robert F.

1983-01-01

A device for detecting current imbalance between phases of a polyphase alternating current generator. A detector responds to the maximum peak current in the generator, and detecting means generates an output for each phase proportional to the peak current of each phase. Comparing means generates an output when the maximum peak current exceeds the phase peak current.

PynPoint code for exoplanet imaging

NASA Astrophysics Data System (ADS)

Amara, A.; Quanz, S. P.; Akeret, J.

2015-04-01

We announce the public release of PynPoint, a Python package that we have developed for analysing exoplanet data taken with the angular differential imaging observing technique. In particular, PynPoint is designed to model the point spread function of the central star and to subtract its flux contribution to reveal nearby faint companion planets. The current version of the package does this correction by using a principal component analysis method to build a basis set for modelling the point spread function of the observations. We demonstrate the performance of the package by reanalysing publicly available data on the exoplanet β Pictoris b, which consists of close to 24,000 individual image frames. We show that PynPoint is able to analyse this typical data in roughly 1.5 min on a Mac Pro, when the number of images is reduced by co-adding in sets of 5. The main computational work, the calculation of the Singular-Value-Decomposition, parallelises well as a result of a reliance on the SciPy and NumPy packages. For this calculation the peak memory load is 6 GB, which can be run comfortably on most workstations. A simpler calculation, by co-adding over 50, takes 3 s with a peak memory usage of 600 MB. This can be performed easily on a laptop. In developing the package we have modularised the code so that we will be able to extend functionality in future releases, through the inclusion of more modules, without it affecting the users application programming interface. We distribute the PynPoint package under GPLv3 licence through the central PyPI server, and the documentation is available online (http://pynpoint.ethz.ch).

Reducing congestion : congestion pricing has promise for improving use of transportation infrastructure

DOT National Transportation Integrated Search

2003-05-06

Congestion pricing can potentially reduce congestion by providing incentives for drivers to shift trips to off-peak periods, use less congested routes, or use alternative modes, thereby spreading out demand for available transportation infrastructure...

Novel measurement of spreading pattern of influenza epidemic by using weighted standard distance method: retrospective spatial statistical study of influenza, Japan, 1999-2009.

PubMed

Shobugawa, Yugo; Wiafe, Seth A; Saito, Reiko; Suzuki, Tsubasa; Inaida, Shinako; Taniguchi, Kiyosu; Suzuki, Hiroshi

2012-06-19

Annual influenza epidemics occur worldwide resulting in considerable morbidity and mortality. Spreading pattern of influenza is not well understood because it is often hampered by the quality of surveillance data that limits the reliability of analysis. In Japan, influenza is reported on a weekly basis from 5,000 hospitals and clinics nationwide under the scheme of the National Infectious Disease Surveillance. The collected data are available to the public as weekly reports which were summarized into number of patient visits per hospital or clinic in each of the 47 prefectures. From this surveillance data, we analyzed the spatial spreading patterns of influenza epidemics using weekly weighted standard distance (WSD) from the 1999/2000 through 2008/2009 influenza seasons in Japan. WSD is a single numerical value representing the spatial compactness of influenza outbreak, which is small in case of clustered distribution and large in case of dispersed distribution. We demonstrated that the weekly WSD value or the measure of spatial compactness of the distribution of reported influenza cases, decreased to its lowest value before each epidemic peak in nine out of ten seasons analyzed. The duration between the lowest WSD week and the peak week of influenza cases ranged from minus one week to twenty weeks. The duration showed significant negative association with the proportion of influenza A/H3N2 cases in early phase of each outbreak (correlation coefficient was -0.75, P = 0.012) and significant positive association with the proportion of influenza B cases in the early phase (correlation coefficient was 0.64, P = 0.045), but positively correlated with the proportion of influenza A/H1N1 strain cases (statistically not significant). It is assumed that the lowest WSD values just before influenza peaks are due to local outbreak which results in small standard distance values. As influenza cases disperse nationwide and an epidemic reaches its peak, WSD value changed to be a progressively increasing. The spatial distribution of nationwide influenza outbreak was measured by using a novel WSD method. We showed that spreading rate varied by type and subtypes of influenza virus using WSD as a spatial indicator. This study is the first to show a relationship between influenza epidemic trend by type/subtype and spatial distribution of influenza nationwide in Japan.

Improved performance of laser wakefield acceleration by tailored self-truncated ionization injection

NASA Astrophysics Data System (ADS)

Irman, A.; Couperus, J. P.; Debus, A.; Köhler, A.; Krämer, J. M.; Pausch, R.; Zarini, O.; Schramm, U.

2018-04-01

We report on tailoring ionization-induced injection in laser wakefield acceleration so that the electron injection process is self-truncating following the evolution of the plasma bubble. Robust generation of high-quality electron beams with shot-to-shot fluctuations of the beam parameters better than 10% is presented in detail. As a novelty, the scheme was found to enable well-controlled yet simple tuning of the injected charge while preserving acceleration conditions and beam quality. Quasi-monoenergetic electron beams at several 100 MeV energy and 15% relative energy spread were routinely demonstrated with a total charge of the monoenergetic feature reaching 0.5 nC. Finally these unique beam parameters, suggesting unprecedented peak currents of several 10 kA, are systematically related to published data on alternative injection schemes.

SU-F-T-673: Effects of Cardiac Induced Brain Pulsations On Proton Minibeams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eagle, J; Marsh, S; Lee, E

Purpose: To quantify the dosimetric impact of internal motion within the brain on spatially modulated proton minibeam radiation therapy (pMRT) for small animal research. Methods: The peak-to-valley dose ratio (PVDR) is an essential dosimetric factor for pMRT. Motion of an animal brain caused by cardiac-induced pulsations (CIP) can impact dose deposition. For synchrotron generated high dose rate X-ray microbeams this effect is evaded due to the quasi-instantaneous delivery. By comparison, pMRT potentially suffers increased spread due to lower dose rates. However, for a given dose rate it is less susceptible to beam spread than microbeams, due to the spatial modulationmore » being an order of magnitude larger. Monte Carlo simulations in TOPAS were used to model the beam spread for a 50.5MeV pMRT beam. Motion effects were simulated for a 50mm thick brass collimator with 0.3mm slit width and 1.0mm center-to-center spacing in a water phantom. The maximum motion in a rat brain due to CIP has been reported to be 0.06mm. Motion was simulated with a peak amplitude in the range 0–0.2mm. Results: The impact of 0.06mm peak motion was minimal and reduced the PVDR by about 1% at a depth of 10mm. For 0.2mm peak motion the PVDR was reduced by 16% at a depth of 10mm. Conclusion: For the pMRT beam the magnitude of cardiac-induced brain motion has minimal impact on the PVDR for the investigated collimator geometry. For more narrow beams the effect is likely to be larger. This indicates that delivery of pMRT to small animal brains should not be affected considerably by beamlines with linac compatible dose rates.« less

The relationship between human behavior and the process of epidemic spreading in a real social network

NASA Astrophysics Data System (ADS)

Grabowski, A.; Rosińska, M.

2012-07-01

On the basis of experimental data on interactions between humans we have investigated the process of epidemic spreading in a social network. We found that the distribution of the number of contacts maintained in one day is exponential. Data on frequency and duration of interpersonal interactions are presented. They allow us to simulate the spread of droplet-/-air-borne infections and to investigate the influence of human dynamics on the epidemic spread. Specifically, we investigated the influence of the distribution of frequency and duration of those contacts on magnitude, epidemic threshold and peak timing of epidemics propagating in respective networks. It turns out that a large increase in the magnitude of an epidemic and a decrease in epidemic threshold are visible if and only if both are taken into account. We have found that correlation between contact frequency and duration strongly influences the effectiveness of control measures like mass immunization campaigns.

An information spreading model based on online social networks

NASA Astrophysics Data System (ADS)

Wang, Tao; He, Juanjuan; Wang, Xiaoxia

2018-01-01

Online social platforms are very popular in recent years. In addition to spreading information, users could review or collect information on online social platforms. According to the information spreading rules of online social network, a new information spreading model, namely IRCSS model, is proposed in this paper. It includes sharing mechanism, reviewing mechanism, collecting mechanism and stifling mechanism. Mean-field equations are derived to describe the dynamics of the IRCSS model. Moreover, the steady states of reviewers, collectors and stiflers and the effects of parameters on the peak values of reviewers, collectors and sharers are analyzed. Finally, numerical simulations are performed on different networks. Results show that collecting mechanism and reviewing mechanism, as well as the connectivity of the network, make information travel wider and faster, and compared to WS network and ER network, the speed of reviewing, sharing and collecting information is fastest on BA network.

Current responsive devices for synchronous generators

DOEpatents

Karlicek, R.F.

1983-09-27

A device for detecting current imbalance between phases of a polyphase alternating current generator. A detector responds to the maximum peak current in the generator, and detecting means generates an output for each phase proportional to the peak current of each phase. Comparing means generates an output when the maximum peak current exceeds the phase peak current. 11 figs.

Designing a range modulator wheel to spread-out the Bragg peak for a passive proton therapy facility

NASA Astrophysics Data System (ADS)

Jia, S. Bijan; Romano, F.; Cirrone, Giuseppe A. P.; Cuttone, G.; Hadizadeh, M. H.; Mowlavi, A. A.; Raffaele, L.

2016-01-01

In proton beam therapy, a Spread-Out Bragg peak (SOBP) is used to establish a uniform dose distribution in the target volume. In order to create a SOBP, several Bragg peaks of different ranges, corresponding to different entrance energies, with certain intensities (weights) should be combined each other. In a passive beam scattering system, the beam is usually extracted from a cyclotron at a constant energy throughout a treatment. Therefore, a SOBP is produced by a range modulator wheel, which is basically a rotating wheel with steps of variable thicknesses, or by using the ridge filters. In this study, we used the Geant4 toolkit to simulate a typical passive scattering beam line. In particular, the CATANA transport beam line of INFN Laboratori Nazionali del Sud (LNS) in Catania has been reproduced in this work. Some initial properties of the entrance beam have been checked by benchmarking simulations with experimental data. A class dedicated to the simulation of the wheel modulators has been implemented. It has been designed in order to be easily modified for simulating any desired modulator wheel and, hence, any suitable beam modulation. By using some auxiliary range-shifters, a set of pristine Bragg peaks was obtained from the simulations. A mathematical algorithm was developed, using the simulated pristine dose profiles as its input, to calculate the weight of each pristine peak, reproduce the SOBP, and finally generate a flat dose distribution. Therefore, once the designed modulator has been realized, it has been tested at CATANA facility, comparing the experimental data with the simulation results.

USB flow characteristics related to noise generation

NASA Technical Reports Server (NTRS)

Brown, W. H.; Reddy, N. N.

1976-01-01

The effects of nozzle and flap geometry on upper surface blown flow field characteristics related to noise generation were examined experimentally using static models. Flow attachment and spreading characteristics were observed using flow visualization techniques. Velocity and turbulence profiles in the trailing edge wake were measured using hot-wire anemometry, and the effects of the geometric variables on peak velocity and turbulence intensity were determined. It is shown that peak trailing edge velocity is a function of the ratio of flow length to modified hydraulic diameter.

Multiple current peaks in room-temperature atmospheric pressure homogenous dielectric barrier discharge plasma excited by high-voltage tunable nanosecond pulse in air

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, De-Zheng; Wang, Wen-Chun; Zhang, Shuai

2013-05-13

Room temperature homogenous dielectric barrier discharge plasma with high instantaneous energy efficiency is acquired by using nanosecond pulse voltage with 20-200 ns tunable pulse width. Increasing the voltage pulse width can lead to the generation of regular and stable multiple current peaks in each discharge sequence. When the voltage pulse width is 200 ns, more than 5 organized current peaks can be observed under 26 kV peak voltage. Investigation also shows that the organized multiple current peaks only appear in homogenous discharge mode. When the discharge is filament mode, organized multiple current peaks are replaced by chaotic filament current peaks.

An improved ChIP-seq peak detection system for simultaneously identifying post-translational modified transcription factors by combinatorial fusion, using SUMOylation as an example.

PubMed

Cheng, Chia-Yang; Chu, Chia-Han; Hsu, Hung-Wei; Hsu, Fang-Rong; Tang, Chung Yi; Wang, Wen-Ching; Kung, Hsing-Jien; Chang, Pei-Ching

2014-01-01

Post-translational modification (PTM) of transcriptional factors and chromatin remodelling proteins is recognized as a major mechanism by which transcriptional regulation occurs. Chromatin immunoprecipitation (ChIP) in combination with high-throughput sequencing (ChIP-seq) is being applied as a gold standard when studying the genome-wide binding sites of transcription factor (TFs). This has greatly improved our understanding of protein-DNA interactions on a genomic-wide scale. However, current ChIP-seq peak calling tools are not sufficiently sensitive and are unable to simultaneously identify post-translational modified TFs based on ChIP-seq analysis; this is largely due to the wide-spread presence of multiple modified TFs. Using SUMO-1 modification as an example; we describe here an improved approach that allows the simultaneous identification of the particular genomic binding regions of all TFs with SUMO-1 modification. Traditional peak calling methods are inadequate when identifying multiple TF binding sites that involve long genomic regions and therefore we designed a ChIP-seq processing pipeline for the detection of peaks via a combinatorial fusion method. Then, we annotate the peaks with known transcription factor binding sites (TFBS) using the Transfac Matrix Database (v7.0), which predicts potential SUMOylated TFs. Next, the peak calling result was further analyzed based on the promoter proximity, TFBS annotation, a literature review, and was validated by ChIP-real-time quantitative PCR (qPCR) and ChIP-reChIP real-time qPCR. The results show clearly that SUMOylated TFs are able to be pinpointed using our pipeline. A methodology is presented that analyzes SUMO-1 ChIP-seq patterns and predicts related TFs. Our analysis uses three peak calling tools. The fusion of these different tools increases the precision of the peak calling results. TFBS annotation method is able to predict potential SUMOylated TFs. Here, we offer a new approach that enhances ChIP-seq data analysis and allows the identification of multiple SUMOylated TF binding sites simultaneously, which can then be utilized for other functional PTM binding site prediction in future.

Spectral investigation of somatotropin for different pH values

NASA Astrophysics Data System (ADS)

Otero de Joshi, Virginia; Gil, Herminia; Contreras, Silvia; Joshi, Narahari V.; Hernandez, Luis

1996-04-01

Spectral investigations of absorbance in deep ultra-violet region (from 200 nm to 350 nm) of (STM) was carried out for different pH values. On the high energy side the peak is located at 195 nm which is generally attributed to peptide bonds. This peak, as expected, does not show any shift with pH value (4.3 to 10.8). A rather broad peak is spread in the region from 200 nm to 240 nm which could be the superposition of the peaks corresponding to the absorption due to (alpha) helix and (beta) structure. This peak shows a red shift as pH value increases. The same hormone was glycated by a conventional method and the process was estimated with the absorption spectra. The results are discussed in the light of nonenzymatic glycation. It was found that glycation mucus somatotropin resistant towards the denaturation process.

Pricing by timing: innovating broadband data plans

NASA Astrophysics Data System (ADS)

Ha, Sangtae; Joe-Wong, Carlee; Sen, Soumya; Chiang, Mung

2012-01-01

Wireless Internet usage is doubling every year. Users are using more of high bandwidth data applications, and the heavy usage concentrates on several peak hours in a day, forcing ISPs to overprovision their networks accordingly. In order to remain profitable, ISPs have been using pricing as a congestion management tool. We review many of such pricing schemes in practice today and argue that they do not solve ISPs' problem of growing data traffic. We believe that dynamic, time-dependent usage pricing, which charges users based on when they access the Internet, can incentivize users to spread out their bandwidth consumption more evenly across different times of the day, thus helping ISPs to overcome the problem of peak congestion. Congestion pricing is not a new idea in itself, but the time for its implementation in data networks has finally arrived. Our key contribution lies in developing new analysis and a fully integrated system architecture, called TUBE (Time-dependent Usage-based Broadband price Engineering) that enables ISPs to implement the proposed TDP plan. The theory, simulation, and system implementation of TUBE system is further complemented with consumer surveys conducted in India and the US, along with preparations for a field trial that is currently underway.

Graphene as current spreading layer on AlGaInP light emitting diodes

NASA Astrophysics Data System (ADS)

Guo, Xia; Feng, Yajie; Liu, Qiaoli; Hu, Anqi; He, Xiaoying; Hu, Zonghai

2018-05-01

Due to high transmittance and high mobility, graphene is one of the promising candidates for a current spreading layer, which is crucial to light emitting diode (LED) performance. In this paper, improved AlGaInP LED performance was reported after graphene was applied on the GaP surface. Due to its lowered work function difference than with the GaN material, the electrical properties remain the same without additional voltage bias. The light output power is enhanced by about 40% under the current injection of 5 mA at room temperature, which was confirmed by the light emission profile analysis in this study. Such results indicate that raphene is a promising candidate as a current spreading layer under low current injection.

HF band filter bank multi-carrier spread spectrum

DOE Office of Scientific and Technical Information (OSTI.GOV)

Laraway, Stephen Andrew; Moradi, Hussein; Farhang-Boroujeny, Behrouz

Abstract—This paper describes modifications to the filter bank multicarrier spread spectrum (FB-MC-SS) system, that was presented in [1] and [2], to enable transmission of this waveform in the HF skywave channel. FB-MC-SS is well suited for the HF channel because it performs well in channels with frequency selective fading and interference. This paper describes new algorithms for packet detection, timing recovery and equalization that are suitable for the HF channel. Also, an algorithm for optimizing the peak to average power ratio (PAPR) of the FBMC- SS waveform is presented. Application of this algorithm results in a waveform with low PAPR.more » Simulation results using a wide band HF channel model demonstrate the robustness of this system over a wide range of delay and Doppler spreads.« less

Enhanced betatron radiation by steering a laser-driven plasma wakefield with a tilted shock front

NASA Astrophysics Data System (ADS)

Yu, Changhai; Liu, Jiansheng; Wang, Wentao; Li, Wentao; Qi, Rong; Zhang, Zhijun; Qin, Zhiyong; Liu, Jiaqi; Fang, Ming; Feng, Ke; Wu, Ying; Ke, Lintong; Chen, Yu; Wang, Cheng; Xu, Yi; Leng, Yuxin; Xia, Changquan; Li, Ruxin; Xu, Zhizhan

2018-03-01

We have experimentally realized a scheme to enhance betatron radiation by manipulating transverse oscillation of electrons in a laser-driven plasma wakefield with a tilted shock front (TSF). Very brilliant betatron x-rays have been produced with significant enhancement both in photon yield and peak energy but almost maintain the e-beam energy spread and charge. Particle-in-cell simulations indicate that the accelerated electron beam (e beam) can acquire a very large transverse oscillation amplitude with an increase in more than 10-fold, after being steered into the deflected wakefield due to the refraction of the driving laser at the TSF. Spectral broadening of betatron radiation can be suppressed owing to the small variation in the peak energy of the low-energy-spread e beam in a plasma wiggler regime. It is demonstrated that the e-beam generation, refracting, and wiggling can act as a whole to realize the concurrence of monoenergetic e beams and bright x-rays in a compact laser-wakefield accelerator.

Characteristics of a normoxic polymethacrylic acid gel dosimeter for a 72-MeV proton beam

NASA Astrophysics Data System (ADS)

Bong, Jihye; Shin, Dongho; Kwon, Soo-Il

2014-01-01

The characteristics of a normoxic polymethacrylic acid gel dosimeter for a 72-MeV proton beam were evaluated. A polymer gel dosimeter was synthesized using gelatin, methacrylic acid, hydroquinone, tetrakis(hydroxymethyl) phosphonium chloride, and highly purified distilled water. The dosimeter was manufactured by placement in a polyethylene (PE) container. Irradiated dosimeters were analyzed to determine the transverse relaxation time (T2) using a 1.5-T MRI. A calibration curve was obtained as a function of the absorbed dose. A Bragg curve made by irradiating the gel with mono-energy was compared with the results for a parallel plate ionization chamber. The spread-out Bragg peak (SOBP) range and distal dose fall-off (DDF) were comparatively analyzed by comparing the irradiated gel with a spread-out Bragg peak against with the ion chamber. Lastly, the gel's usefulness as a dosimeter for therapeutic radiation quality assurance was evaluated by obtaining its practical field size, flatness, and symmetry, through comparison of the profiles of the gel and ion chamber.

9 GeV energy gain in a beam-driven plasma wakefield accelerator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Litos, M.; Adli, E.; Allen, J. M.

2016-02-15

An electron beam has gained a maximum energy of 9 GeV per particle in a 1.3 m-long electron beam-driven plasma wakefield accelerator. The amount of charge accelerated in the spectral peak was 28.3 pC, and the root-mean-square energy spread was 5.0%. The mean accelerated charge and energy gain per particle of the 215 shot data set was 115 pC and 5.3 GeV, respectively, corresponding to an acceleration gradient of 4.0 GeV m -1 at the spectral peak. Moreover, the mean energy spread of the data set was 5.1%. Our results are consistent with the extrapolation of the previously reported energymore » gain results using a shorter, 36 cm-long plasma source to within 10%, evincing a non-evolving wake structure that can propagate distances of over a meter in length. Wake-loading effects were evident in the data through strong dependencies observed between various spectral properties and the amount of accelerated charge.« less

Ion energy spread and current measurements of the rf-driven multicusp ion source

NASA Astrophysics Data System (ADS)

Lee, Y.; Gough, R. A.; Kunkel, W. B.; Leung, K. N.; Perkins, L. T.; Pickard, D. S.; Sun, L.; Vujic, J.; Williams, M. D.; Wutte, D.

1997-03-01

Axial energy spread and useful beam current of positive ion beams have been carried out using a radio frequency (rf)-driven multicusp ion source. Operating the source with a 13.56 MHz induction discharge, the axial energy spread is found to be approximately 3.2 eV. The extractable beam current of the rf-driven source is found to be comparable to that of filament-discharge sources. With a 0.6 mm diameter extraction aperture, a positive hydrogen ion beam current density of 80 mA/cm2 can be obtained at a rf input power of 2.5 kW. The expected source lifetime is much longer than that of filament discharges.

Numerical investigation of a laser gun injector at CEBAF

DOE Office of Scientific and Technical Information (OSTI.GOV)

Byung Yunn; Charles Sinclair; David Neuffer

1993-08-23

A laser gun injector is being developed based on the superconducting rf technologies established at CEBAF. This injector will serve as a high charge cw source for a high power free electron laser. It consists of a dc laser gun, a buncher, a cryounit and a chicane. Its space-charge-dominated performance has been thoroughly investigated using the time-consuming but more appropriate point-by-point space charge calculation method in PARMELA. The notion of ``conditioning for final bunching'' will be introduced. This concept has been built into the code and has greatly facilitated the optimization of the whole system to achieve the highest possiblemore » peak current while maintaining low emittance and low energy spread. Extensive parameter variation studies have shown that the design will perform better than the specifications.« less

Use of tripolar electrodes for minimization of current spread in uncut peripheral nerve stimulation.

PubMed

Ohsawa, Ichiro; Inui, Koji

2009-05-01

The electrical stimulation of an uncut peripheral nerve requires a countermeasure to avoid the spread of current through a loop pathway formed outside the electrode array. Here the use of tripolar electrodes (TE) is proposed. By binding the two end poles, current spread through the loop pathway can theoretically be eliminated since both end poles are held equipotential. Experimentally, we tested the validity of this approach. In chloralose-urethane anesthetized rats, the left cervical vagus (LCV) was placed on TE which could function as such or as bipolar electrodes (BE) by the use of a selector switch. The spread of current to the adjacent tissues (rectus capitis muscle underlying the LCV, and the right cervical vagus (RCV) incised and translocated beside the target, LCV) was compared between TE and BE. When the stimulus intensity was increased, contraction occurred in the capitis muscle with BE, but not TE. Compound spike potentials of A fiber origin were evoked in the non-target RCV on high-intensity stimulation with BE, but not TE. Constant voltage stimulation of the LCV with TE produced bradycardia of the same magnitude as that with BE. In conclusion, constant voltage stimulation using TE can minimize current spread without changing the stimulus's effects.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garimella, Sandilya V. B.; Ibrahim, Yehia M.; Tang, Keqi

A novel concept for ion spatial peak compression is described, and discussed primarily in the context of ion mobility spectrometry (IMS). Using theoretical and numerical methods, the effects of using non-constant (e.g., linearly varying) electric fields on ion distributions (e.g., an ion mobility peak) is evaluated both in the physical and temporal domains. The application of linearly decreasing electric field in conjunction with conventional drift field arrangements is shown to lead to a reduction in IMS physical peak width. When multiple ion packets in a selected mobility window are simultaneously subjected to such fields, there is ion packet compression, i.e.,more » a reduction in peak widths of all species. This peak compression occurs with a modest reduction of resolution, but which can be quickly recovered as ions drift in a constant field after the compression event. Compression also yields a significant increase in peak intensities. In addition, approaches for peak compression in traveling wave IMS are also discussed. Ion mobility peak compression can be particularly useful for mitigating diffusion driven peak spreading over very long path length separations (e.g., in cyclic multi-pass arrangements), and for achieving higher S/N and IMS resolution over a selected mobility range.« less

A wavelet transform algorithm for peak detection and application to powder x-ray diffraction data.

PubMed

Gregoire, John M; Dale, Darren; van Dover, R Bruce

2011-01-01

Peak detection is ubiquitous in the analysis of spectral data. While many noise-filtering algorithms and peak identification algorithms have been developed, recent work [P. Du, W. Kibbe, and S. Lin, Bioinformatics 22, 2059 (2006); A. Wee, D. Grayden, Y. Zhu, K. Petkovic-Duran, and D. Smith, Electrophoresis 29, 4215 (2008)] has demonstrated that both of these tasks are efficiently performed through analysis of the wavelet transform of the data. In this paper, we present a wavelet-based peak detection algorithm with user-defined parameters that can be readily applied to the application of any spectral data. Particular attention is given to the algorithm's resolution of overlapping peaks. The algorithm is implemented for the analysis of powder diffraction data, and successful detection of Bragg peaks is demonstrated for both low signal-to-noise data from theta-theta diffraction of nanoparticles and combinatorial x-ray diffraction data from a composition spread thin film. These datasets have different types of background signals which are effectively removed in the wavelet-based method, and the results demonstrate that the algorithm provides a robust method for automated peak detection.

Enhanced wall-plug efficiency in AlGaN-based deep-ultraviolet light-emitting diodes with uniform current spreading p-electrode structures

NASA Astrophysics Data System (ADS)

Hao, Guo-Dong; Taniguchi, Manabu; Tamari, Naoki; Inoue, Shin-ichiro

2016-06-01

The current crowding is an especially severe issue in AlGaN-based deep-ultraviolet (DUV) light-emitting diodes (LEDs) because of the low conductivity of the n-AlGaN cladding layer that has a high Al fraction. We theoretically investigated the improvement in internal quantum efficiency and total resistances in DUV-LEDs with an emission wavelength of 265 nm by a well-designed p-electrode geometry to produce uniform current spreading. As a result, the wall-plug efficiency was enhanced by a factor of 60% at an injection current of 350 mA in the designed uniform-current-spreading p-electrode LED when compared with an LED with a conventional cross-bar p-electrode pattern.

Novel measurement of spreading pattern of influenza epidemic by using weighted standard distance method: retrospective spatial statistical study of influenza, Japan, 1999–2009

PubMed Central

2012-01-01

Background Annual influenza epidemics occur worldwide resulting in considerable morbidity and mortality. Spreading pattern of influenza is not well understood because it is often hampered by the quality of surveillance data that limits the reliability of analysis. In Japan, influenza is reported on a weekly basis from 5,000 hospitals and clinics nationwide under the scheme of the National Infectious Disease Surveillance. The collected data are available to the public as weekly reports which were summarized into number of patient visits per hospital or clinic in each of the 47 prefectures. From this surveillance data, we analyzed the spatial spreading patterns of influenza epidemics using weekly weighted standard distance (WSD) from the 1999/2000 through 2008/2009 influenza seasons in Japan. WSD is a single numerical value representing the spatial compactness of influenza outbreak, which is small in case of clustered distribution and large in case of dispersed distribution. Results We demonstrated that the weekly WSD value or the measure of spatial compactness of the distribution of reported influenza cases, decreased to its lowest value before each epidemic peak in nine out of ten seasons analyzed. The duration between the lowest WSD week and the peak week of influenza cases ranged from minus one week to twenty weeks. The duration showed significant negative association with the proportion of influenza A/H3N2 cases in early phase of each outbreak (correlation coefficient was −0.75, P = 0.012) and significant positive association with the proportion of influenza B cases in the early phase (correlation coefficient was 0.64, P = 0.045), but positively correlated with the proportion of influenza A/H1N1 strain cases (statistically not significant). It is assumed that the lowest WSD values just before influenza peaks are due to local outbreak which results in small standard distance values. As influenza cases disperse nationwide and an epidemic reaches its peak, WSD value changed to be a progressively increasing. Conclusions The spatial distribution of nationwide influenza outbreak was measured by using a novel WSD method. We showed that spreading rate varied by type and subtypes of influenza virus using WSD as a spatial indicator. This study is the first to show a relationship between influenza epidemic trend by type/subtype and spatial distribution of influenza nationwide in Japan. PMID:22713508

Electric Field and Plasma Density Observations of Irregularities and Plasma Instabilities in the Low Latitude Ionosphere Gathered by the C/NOFS Satellite

NASA Technical Reports Server (NTRS)

Pfaff, Robert F.; Freudenreich, H.; Rowland, D.; Klenzing, J.; Liebrecht, C.

2012-01-01

The Vector Electric Field Investigation (VEFI) on the C/NOFS equatorial satellite provides a unique data set which includes detailed measurements of irregularities associated with the equatorial ionosphere and in particular with spread-F depletions. We present vector AC electric field observations gathered on C/NOFS that address a variety of key questions regarding how plasma irregularities, from meter to kilometer scales, are created and evolve. The talk focuses on occasions where the ionosphere F-peak has been elevated above the C/NOFS satellite perigee of 400 km as solar activity has increased. In particular, during the equinox periods of 2011, the satellite consistently journeyed below the F-peak whenever the orbit was in the region of the South Atlantic anomaly after sunset. During these passes, data from the electric field and plasma density probes on the satellite have revealed two types of instabilities which had not previously been observed in the C/NOFS data set: The first is evidence for 400-500km-scale bottomside "undulations" that appear in the density and electric field data. In one case, these large scale waves are associated with a strong shear in the zonal E x B flow, as evidenced by variations in the meridional (outward) electric fields observed above and below the F-peak. These undulations are devoid of smaller scale structures in the early evening, yet appear at later local times along the same orbit associated with fully-developed spread-F with smaller scale structures. This suggests that they may be precursor waves for spread-F, driven by a collisional shear instability, following ideas advanced previously by researchers using data from the Jicamarca radar. A second result is the appearance of km-scale irregularities that are a common feature in the electric field and plasma density data that also appear when the satellite is near or below the F-peak at night. The vector electric field instrument on C/NOFS clearly shows that the electric field component of these waves is strongest in the zonal direction. These waves are strongly correlated with simultaneous observations of plasma density oscillations and appear both with, and without, evidence of larger-scale spread-F depletions. These km-scale, quasi-coherent waves strongly resemble the bottomside, sinusoidal irregularities reported in the Atmosphere Explorer satellite data set by Valladares et al. and are believed to cause scintillations of VHF radiowaves. We interpret these new observations in terms of fundamental plasma instabilities associated with the unstable, nighttime equatorial ionosphere.

Space shuttle exhaust plumes in the lower thermosphere: Advective transport and diffusive spreading

NASA Astrophysics Data System (ADS)

Stevens, Michael H.; Lossow, Stefan; Siskind, David E.; Meier, R. R.; Randall, Cora E.; Russell, James M.; Urban, Jo; Murtagh, Donal

2014-02-01

The space shuttle main engine plume deposited between 100 and 115 km altitude is a valuable tracer for global-scale dynamical processes. Several studies have shown that this plume can reach the Arctic or Antarctic to form bursts of polar mesospheric clouds (PMCs) within a few days. The rapid transport of the shuttle plume is currently not reproduced by general circulation models and is not well understood. To help delineate the issues, we present the complete satellite datasets of shuttle plume observations by the Sounding of the Atmosphere using Broadband Emission Radiometry instrument and the Sub-Millimeter Radiometer instrument. From 2002 to 2011 these two instruments observed 27 shuttle plumes in over 600 limb scans of water vapor emission, from which we derive both advective meridional transport and diffusive spreading. Each plume is deposited at virtually the same place off the United States east coast so our results are relevant to northern mid-latitudes. We find that the advective transport for the first 6-18 h following deposition depends on the local time (LT) of launch: shuttle plumes deposited later in the day (~13-22 LT) typically move south whereas they otherwise typically move north. For these younger plumes rapid transport is most favorable for launches at 6 and 18 LT, when the displacement is 10° in latitude corresponding to an average wind speed of 30 m/s. For plumes between 18 and 30 h old some show average sustained meridional speeds of 30 m/s. For plumes between 30 and 54 h old the observations suggest a seasonal dependence to the meridional transport, peaking near the beginning of year at 24 m/s. The diffusive spreading of the plume superimposed on the transport is on average 23 m/s in 24 h. The plume observations show large variations in both meridional transport and diffusive spreading so that accurate modeling requires knowledge of the winds specific to each case. The combination of transport and spreading from the STS-118 plume in August 2007 formed bright PMCs between 75 and 85°N a day after launch. These are the highest latitude Arctic PMCs formed by shuttle exhaust reported to date.

Influence of climate cycles on grapevine domestication and ancient migrations in Eurasia.

PubMed

Mariani, Luigi; Cola, Gabriele; Maghradze, David; Failla, Osvaldo; Zavatti, Franco

2018-09-01

The objective of this work is to investigate the Holocenic climate cycles that may have influenced the domestication of grapevine in the Subcaucasian area and its subsequent spread in Eurasia. The analysis covered the longitudinal belt ranging from the Iberian Peninsula to Japan, seen as the preferential pathway for the Holocenic spread of grapevine and many other crops in Eurasia. Spectral analysis was considered as the criterion of investigation and the Holocenic cycles were analyzed considering different geochemical and biological proxies, of which seven are directly referred to vine. In this context the relation of the abovementioned proxies with spectral peaks of possible causal factors like Solar activity (SA), North Atlantic oceanic factors (Atlantic Multidecadal Oscillation - AMO and North Atlantic Oscillation - NAO), and subtropical oceanic factors (El Nino Southern Oscillation - ENSO) was also analyzed. In order to acquire a sufficiently wide number of proxies sensitive to the causal factors, we referred to a latitudinal belt wider than the one colonized by vine, also acquiring proxy from the Scandinavian area, notoriously susceptible to North Atlantic forcings. The analysis of the proxy spectral peaks, considering 20 classes with a 50-years step in the 0-1000 years range, showed that the 50% of the classes have a higher frequency of peaks at East than West, the 20% a higher frequency at West than East and the 10% an equal frequency, showing the efficiency of the propagation of Western signals towards the center of Eurasia. The search of the causal factors spectral peaks in the proxy series showed that AMO, NAO and SA acted with a certain regularity on the entire belt investigated both latitudinally and longitudinally, while spectral peaks linked to ENSO underwent a considerable attenuation moving northward. Finally, the specific analysis on viticultural proxies showed common peaks with causal factors. Copyright © 2018 Elsevier B.V. All rights reserved.

Enhanced performance of photonic crystal GaN light-emitting diodes with graphene transparent electrodes

NASA Astrophysics Data System (ADS)

Ge, Hai-Liang; Xu, Chen; Xu, Kun; Xun, Meng; Wang, Jun; Liu, Jie

2015-03-01

The two-dimensional (2D) triangle lattice air hole photonic crystal (PC) GaN-based light-emitting diodes (LED) with double-layer graphene transparent electrodes (DGTE) have been produced. The current spreading effect of the double-layer graphene (GR) on the surface of the PC structure of the LED has been researched. Specially, we found that the part of the graphene suspending over the air hole of the PC structure was of much higher conductivity, which reduced the average sheet resistance of the graphene transparent conducting electrode and improved the current spreading of the PC LED. Therefore, the work voltage of the DGTE-PC LED was obviously decreased, and the output power was greatly enhanced. The COMSOL software was used to simulate the current density distribution of the samples. The results show that the etching of PC structure results in the degradation of the current spreading and that the graphene transparent conducting electrode can offer an uniform current spreading in the DGTE-PC LED. PACS: 85.60.Jb; 68.65.Pq; 42.70.Qs

Dose ratio proton radiography using the proximal side of the Bragg peak

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doolan, P. J., E-mail: paul.doolan.09@ucl.ac.uk; Royle, G.; Gibson, A.

Purpose: In recent years, there has been a movement toward single-detector proton radiography, due to its potential ease of implementation within the clinical environment. One such single-detector technique is the dose ratio method in which the dose maps from two pristine Bragg peaks are recorded beyond the patient. To date, this has only been investigated on the distal side of the lower energy Bragg peak, due to the sharp falloff. The authors investigate the limits and applicability of the dose ratio method on the proximal side of the lower energy Bragg peak, which has the potential to allow a muchmore » wider range of water-equivalent thicknesses (WET) to be imaged. Comparisons are made with the use of the distal side of the Bragg peak. Methods: Using the analytical approximation for the Bragg peak, the authors generated theoretical dose ratio curves for a range of energy pairs, and then determined how an uncertainty in the dose ratio would translate to a spread in the WET estimate. By defining this spread as the accuracy one could achieve in the WET estimate, the authors were able to generate lookup graphs of the range on the proximal side of the Bragg peak that one could reliably use. These were dependent on the energy pair, noise level in the dose ratio image and the required accuracy in the WET. Using these lookup graphs, the authors investigated the applicability of the technique for a range of patient treatment sites. The authors validated the theoretical approach with experimental measurements using a complementary metal oxide semiconductor active pixel sensor (CMOS APS), by imaging a small sapphire sphere in a high energy proton beam. Results: Provided the noise level in the dose ratio image was 1% or less, a larger spread of WETs could be imaged using the proximal side of the Bragg peak (max 5.31 cm) compared to the distal side (max 2.42 cm). In simulation, it was found that, for a pediatric brain, it is possible to use the technique to image a region with a square field equivalent size of 7.6 cm{sup 2}, for a required accuracy in the WET of 3 mm and a 1% noise level in the dose ratio image. The technique showed limited applicability for other patient sites. The CMOS APS demonstrated a good accuracy, with a root-mean-square-error of 1.6 mm WET. The noise in the measured images was found to be σ = 1.2% (standard deviation) and theoretical predictions with a 1.96σ noise level showed good agreement with the measured errors. Conclusions: After validating the theoretical approach with measurements, the authors have shown that the use of the proximal side of the Bragg peak when performing dose ratio imaging is feasible, and allows for a wider dynamic range than when using the distal side. The dynamic range available increases as the demand on the accuracy of the WET decreases. The technique can only be applied to clinical sites with small maximum WETs such as for pediatric brains.« less

WE-F-16A-02: Design, Fabrication, and Validation of a 3D-Printed Proton Filter for Range Spreading

DOE Office of Scientific and Technical Information (OSTI.GOV)

Remmes, N; Courneyea, L; Corner, S

2014-06-15

Purpose: To design, fabricate and test a 3D-printed filter for proton range spreading in scanned proton beams. The narrow Bragg peak in lower-energy synchrotron-based scanned proton beams can result in longer treatment times for shallow targets due to energy switching time and plan quality degradation due to minimum monitor unit limitations. A filter with variable thicknesses patterned on the same scale as the beam's lateral spot size will widen the Bragg peak. Methods: The filter consists of pyramids dimensioned to have a Gaussian distribution in thickness. The pyramids are 2.5mm wide at the base, 0.6 mm wide at the peak,more » 5mm tall, and are repeated in a 2.5mm pseudo-hexagonal lattice. Monte Carlo simulations of the filter in a proton beam were run using TOPAS to assess the change in depth profiles and lateral beam profiles. The prototypes were constrained to a 2.5cm diameter disk to allow for micro-CT imaging of promising prototypes. Three different 3D printers were tested. Depth-doses with and without the prototype filter were then measured in a ~70MeV proton beam using a multilayer ion chamber. Results: The simulation results were consistent with design expectations. Prototypes printed on one printer were clearly unacceptable on visual inspection. Prototypes on a second printer looked acceptable, but the micro-CT image showed unacceptable voids within the pyramids. Prototypes from the third printer appeared acceptable visually and on micro-CT imaging. Depth dose scans using the prototype from the third printer were consistent with simulation results. Bragg peak width increased by about 3x. Conclusions: A prototype 3D printer pyramid filter for range spreading was successfully designed, fabricated and tested. The filter has greater design flexibility and lower prototyping and production costs compared to traditional ridge filters. Printer and material selection played a large role in the successful development of the filter.« less

Correlated peak relative light intensity and peak current in triggered lightning subsequent return strokes

NASA Technical Reports Server (NTRS)

Idone, V. P.; Orville, R. E.

1985-01-01

The correlation between peak relative light intensity L(R) and stroke peak current I(R) is examined for 39 subsequent return strokes in two triggered lightning flashes. One flash contained 19 strokes and the other 20 strokes for which direct measurements were available of the return stroke peak current at ground. Peak currents ranged from 1.6 to 21 kA. The measurements of peak relative light intensity were obtained from photographic streak recordings using calibrated film and microsecond resolution. Correlations, significant at better than the 0.1 percent level, were found for several functional relationships. Although a relation between L(R) and I(R) is evident in these data, none of the analytical relations considered is clearly favored. The correlation between L(R) and the maximum rate of current rise is also examined, but less correlation than between L(R) and I(R) is found. In addition, the peak relative intensity near ground is evaluated for 22 dart leaders, and a mean ratio of peak dart leader to peak return stroke relative light intensity was found to be 0.1 with a range of 0.02-0.23. Using two different methods, the peak current near ground in these dart leaders is estimated to range from 0.1 to 6 kA.

Prediction of fire growth on furniture using CFD

NASA Astrophysics Data System (ADS)

Pehrson, Richard David

A fire growth calculation method has been developed that couples a computational fluid dynamics (CFD) model with bench scale cone calorimeter test data for predicting the rate of flame spread on compartment contents such as furniture. The commercial CFD code TASCflow has been applied to solve time averaged conservation equations using an algebraic multigrid solver with mass weighted skewed upstream differencing for advection. Closure models include k-e for turbulence, eddy breakup for combustion following a single step irreversible reaction with Arrhenius rate constant, finite difference radiation transfer, and conjugate heat transfer. Radiation properties are determined from concentrations of soot, CO2 and H2O using the narrow band model of Grosshandler and exponential wide band curve fit model of Modak. The growth in pyrolyzing area is predicted by treating flame spread as a series of piloted ignitions based on coupled gas-fluid boundary conditions. The mass loss rate from a given surface element follows the bench scale test data for input to the combustion prediction. The fire growth model has been tested against foam-fabric mattresses and chairs burned in the furniture calorimeter. In general, agreement between model and experiment for peak heat release rate (HRR), time to peak HRR, and total energy lost is within +/-20%. Used as a proxy for the flame spread velocity, the slope of the HRR curve predicted by model agreed with experiment within +/-20% for all but one case.

Evidence for complex contagion models of social contagion from observational data

PubMed Central

Sprague, Daniel A.

2017-01-01

Social influence can lead to behavioural ‘fads’ that are briefly popular and quickly die out. Various models have been proposed for these phenomena, but empirical evidence of their accuracy as real-world predictive tools has so far been absent. Here we find that a ‘complex contagion’ model accurately describes the spread of behaviours driven by online sharing. We found that standard, ‘simple’, contagion often fails to capture both the rapid spread and the long tails of popularity seen in real fads, where our complex contagion model succeeds. Complex contagion also has predictive power: it successfully predicted the peak time and duration of the ALS Icebucket Challenge. The fast spread and longer duration of fads driven by complex contagion has important implications for activities such as publicity campaigns and charity drives. PMID:28686719

Two-Dimensional Optical CDMA System Parameters Limitations for Wavelength Hopping/Time-Spreading Scheme based on Simulation Experiment

NASA Astrophysics Data System (ADS)

Kandouci, Chahinaz; Djebbari, Ali

2018-04-01

A new family of two-dimensional optical hybrid code which employs zero cross-correlation (ZCC) codes, constructed by the balanced incomplete block design BIBD, as both time-spreading and wavelength hopping patterns are used in this paper. The obtained codes have both off-peak autocorrelation and cross-correlation values respectively equal to zero and unity. The work in this paper is a computer experiment performed using Optisystem 9.0 software program as a simulator to determine the wavelength hopping/time spreading (WH/TS) OCDMA system performances limitations. Five system parameters were considered in this work: the optical fiber length (transmission distance), the bitrate, the chip spacing and the transmitted power. This paper shows for what sufficient system performance parameters (BER≤10-9, Q≥6) the system can stand for.

High-quality electron beams from beam-driven plasma accelerators by wakefield-induced ionization injection.

PubMed

Martinez de la Ossa, A; Grebenyuk, J; Mehrling, T; Schaper, L; Osterhoff, J

2013-12-13

We propose a new and simple strategy for controlled ionization-induced trapping of electrons in a beam-driven plasma accelerator. The presented method directly exploits electric wakefields to ionize electrons from a dopant gas and capture them into a well-defined volume of the accelerating and focusing wake phase, leading to high-quality witness bunches. This injection principle is explained by example of three-dimensional particle-in-cell calculations using the code OSIRIS. In these simulations a high-current-density electron-beam driver excites plasma waves in the blowout regime inside a fully ionized hydrogen plasma of density 5×10(17)cm-3. Within an embedded 100  μm long plasma column contaminated with neutral helium gas, the wakefields trigger ionization, trapping of a defined fraction of the released electrons, and subsequent acceleration. The hereby generated electron beam features a 1.5 kA peak current, 1.5  μm transverse normalized emittance, an uncorrelated energy spread of 0.3% on a GeV-energy scale, and few femtosecond bunch length.

A comparison between the current models of mid-latitude spread F and data from the Arecibo Observatory

NASA Technical Reports Server (NTRS)

Imel, G.

1977-01-01

The current models of mid-latitude F sub s are studied. The assumptions and derivations of the Reid model, the Scannapieco model, and the Perkins model are presented in detail. Incoherent-scatter data of the density profiles and velocity profiles were obtained in order that the models could be evaluated on the basis of experimental data. Initial studies indicated that the Perkins model was most representative of the data from Arecibo, so a detailed comparison of the predictions of the Perkins model and the data was made. Two of four nights studied are nights with F sub s. The Perkins model is derived in a frame of reference moving with the velocity of the neutral wind; the model is transformed to the rest frame to facilitate comparison with data. Several data handling techniques are introduced. In particular, an integration interval that remains constant in length, but follows the vertical motion of the peak of the F layer is used to obtain the field integrated quantities of the Perkins model.

Modeling Electrically Evoked Otoacoustic Emissions

NASA Astrophysics Data System (ADS)

Grosh, K.; Deo, N.; Parthasarathi, A. A.; Nuttall, A. L.; Zheng, J. F.; Ren, T. Y.

2003-02-01

Electrical evoked otoacoustic emissions (EEOAE) are used to investigate in vivo cochlear electromechanical function. Round window electrical stimulation gives rise to a broad frequency EEOAE response, from 100 Hz or below to 40 kHz in guinea pigs. Placing bipolar electrodes very close to the basilar membrane (in the scala vestibuli and scala tympani) gives rise to a much narrower frequency range of EEOAE, limited to around 20 kHz when the electrodes are placed near the 18 kHz best frequency place. Model predictions using a three dimensional fluid model in conjunction with a simple model for outer hair cell (OHC) activity are used to interpret the experimental results. The model is solved using a 2.5D finite-element formulation. Predictions show that the high-frequency limit of the excitation is determined by the spatial extent of the current stimulus (also called the current spread). The global peaks in the EEOAE spectra are interpreted as constructive interference between electrically evoked backward traveling waves and forward traveling waves reflected from the stapes. Steady-state response predictions of the model are presented.

A fundamental look at fire spread in California chaparral

Treesearch

David R. Weise; Thomas Fletcher; Larry Baxter; Shankar Mahalingam; Xiangyang Zhou; Patrick Pagni; Rod Linn; Bret Butler

2004-01-01

The USDA Forest Service National Fire Plan funded a research program to study fire spread in live fuels of the southwestern United States. In the U.S. current operational fire spread models do not distinguish between live and dead fuels in a sophisticated manner because the study of live fuels has been limited. The program is experimentally examining fire spread at 3...

Role of peak current in conversion of patients with ventricular fibrillation.

PubMed

Anantharaman, Venkataraman; Wan, Paul Weng; Tay, Seow Yian; Manning, Peter George; Lim, Swee Han; Chua, Siang Jin Terrance; Mohan, Tiru; Rabind, Antony Charles; Vidya, Sudarshan; Hao, Ying

2017-07-01

Peak currents are the final arbiter of defibrillation in patients with ventricular fibrillation (VF). However, biphasic defibrillators continue to use energy in joules for electrical conversion in hopes that their impedance compensation properties will address transthoracic impedance (TTI), which must be overcome when a fixed amount of energy is delivered. However, optimal peak currents for conversion of VF remain unclear. We aimed to determine the role of peak current and optimal peak levels for conversion in collapsed VF patients. Adult, non-pregnant patients presenting with non-traumatic VF were included in the study. All defibrillations that occurred were included. Impedance values during defibrillation were used to calculate peak current values. The endpoint was return of spontaneous circulation (ROSC). Of the 197 patients analysed, 105 had ROSC. Characteristics of patients with and without ROSC were comparable. Short duration of collapse < 10 minutes correlated positively with ROSC. Generally, patients with average or high TTI converted at lower peak currents. 25% of patients with high TTI converted at 13.3 ± 2.3 A, 22.7% with average TTI at 18.2 ± 2.5 A and 18.6% with low TTI at 27.0 ± 4.7 A (p = 0.729). Highest peak current conversions were at < 15 A and 15-20 A. Of the 44 patients who achieved first-shock ROSC, 33 (75.0%) received < 20 A peak current vs. > 20 A for the remaining 11 (25%) patients (p = 0.002). For best effect, priming biphasic defibrillators to deliver specific peak currents should be considered. Copyright: © Singapore Medical Association

Role of peak current in conversion of patients with ventricular fibrillation

PubMed Central

Anantharaman, Venkataraman; Wan, Paul Weng; Tay, Seow Yian; Manning, Peter George; Lim, Swee Han; Chua, Siang Jin Terrance; Mohan, Tiru; Rabind, Antony Charles; Vidya, Sudarshan; Hao, Ying

2017-01-01

INTRODUCTION Peak currents are the final arbiter of defibrillation in patients with ventricular fibrillation (VF). However, biphasic defibrillators continue to use energy in joules for electrical conversion in hopes that their impedance compensation properties will address transthoracic impedance (TTI), which must be overcome when a fixed amount of energy is delivered. However, optimal peak currents for conversion of VF remain unclear. We aimed to determine the role of peak current and optimal peak levels for conversion in collapsed VF patients. METHODS Adult, non-pregnant patients presenting with non-traumatic VF were included in the study. All defibrillations that occurred were included. Impedance values during defibrillation were used to calculate peak current values. The endpoint was return of spontaneous circulation (ROSC). RESULTS Of the 197 patients analysed, 105 had ROSC. Characteristics of patients with and without ROSC were comparable. Short duration of collapse < 10 minutes correlated positively with ROSC. Generally, patients with average or high TTI converted at lower peak currents. 25% of patients with high TTI converted at 13.3 ± 2.3 A, 22.7% with average TTI at 18.2 ± 2.5 A and 18.6% with low TTI at 27.0 ± 4.7 A (p = 0.729). Highest peak current conversions were at < 15 A and 15–20 A. Of the 44 patients who achieved first-shock ROSC, 33 (75.0%) received < 20 A peak current vs. > 20 A for the remaining 11 (25%) patients (p = 0.002). CONCLUSION For best effect, priming biphasic defibrillators to deliver specific peak currents should be considered. PMID:28741007

Masked Priming Effects in Aphasia: Evidence for Altered Automatic Spreading Activation

PubMed Central

Silkes, JoAnn P.; Rogers, Margaret A.

2015-01-01

Purpose Previous research has suggested that impairments of automatic spreading activation may underlie some aphasic language deficits. This study further investigated the status of automatic spreading activation in individuals with aphasia as compared with typical adults. Method Participants were 21 individuals with aphasia (12 fluent, 9 non-fluent) and 31 typical adults. Reaction time data were collected on a lexical decision task with masked repetition primes, assessed at 11 different interstimulus intervals (ISIs). Masked primes were used to assess automatic spreading activation without the confound of conscious processing. The various ISIs were used to assess the time to onset, and duration, of priming effects. Results The control group showed maximal priming in the 200 ms ISI condition, with significant priming at a range of ISIs surrounding that peak. Participants with both fluent and non-fluent aphasia showed maximal priming effects in the 250 ms ISI condition, and primed across a smaller range of ISIs than the control group. Conclusions Results suggest that individuals with aphasia have slowed automatic spreading activation, and impaired maintenance of activation over time, regardless of fluency classification. These findings have implications for understanding aphasic language impairment and for development of aphasia treatments designed directly address automatic language processes. PMID:22411281

Monitoring of Time-Dependent System Profiles by Multiplex Gas Chromatography with Maximum Entropy Demodulation

NASA Technical Reports Server (NTRS)

Becker, Joseph F.; Valentin, Jose

1996-01-01

The maximum entropy technique was successfully applied to the deconvolution of overlapped chromatographic peaks. An algorithm was written in which the chromatogram was represented as a vector of sample concentrations multiplied by a peak shape matrix. Simulation results demonstrated that there is a trade off between the detector noise and peak resolution in the sense that an increase of the noise level reduced the peak separation that could be recovered by the maximum entropy method. Real data originated from a sample storage column was also deconvoluted using maximum entropy. Deconvolution is useful in this type of system because the conservation of time dependent profiles depends on the band spreading processes in the chromatographic column, which might smooth out the finer details in the concentration profile. The method was also applied to the deconvolution of previously interpretted Pioneer Venus chromatograms. It was found in this case that the correct choice of peak shape function was critical to the sensitivity of maximum entropy in the reconstruction of these chromatograms.

Integrated numerical modeling of a laser gun injector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, H.; Benson, S.; Bisognano, J.

1993-06-01

CEBAF is planning to incorporate a laser gun injector into the linac front end as a high-charge cw source for a high-power free electron laser and nuclear physics. This injector consists of a DC laser gun, a buncher, a cryounit and a chicane. The performance of the injector is predicted based on integrated numerical modeling using POISSON, SUPERFISH and PARMELA. The point-by-point method incorporated into PARMELA by McDonald is chosen for space charge treatment. The concept of ``conditioning for final bunching`` is employed to vary several crucial parameters of the system for achieving highest peak current while maintaining low emittancemore » and low energy spread. Extensive parameter variation studies show that the design will perform beyond the specifications for FEL operations aimed at industrial applications and fundamental scientific research. The calculation also shows that the injector will perform as an extremely bright cw electron source.« less

Electroluminescence of ordered ZnO nanorod array/p-GaN light-emitting diodes with graphene current spreading layer

PubMed Central

2014-01-01

Ordered ZnO nanorod array/p-GaN heterojunction light-emitting diodes (LEDs) have been fabricated by introducing graphene as the current spreading layer, which exhibit improved electroluminescence performance by comparison to the LED using a conventional structure (indium-tin-oxide as the current spreading layer). In addition, by adjusting the diameter of ZnO nanorod array in use, the light emission of the ZnO nanorod array/p-GaN heterojunction LEDs was enhanced further. This work has great potential applications in solid-state lighting, high performance optoelectronic devices, and so on. PACS 78.60.Fi; 85.60.Jb; 78.67.Lt; 81.10.Dn PMID:25489284

Electroluminescence of ordered ZnO nanorod array/p-GaN light-emitting diodes with graphene current spreading layer.

PubMed

Dong, Jing-Jing; Hao, Hui-Ying; Xing, Jie; Fan, Zhen-Jun; Zhang, Zi-Li

2014-01-01

Ordered ZnO nanorod array/p-GaN heterojunction light-emitting diodes (LEDs) have been fabricated by introducing graphene as the current spreading layer, which exhibit improved electroluminescence performance by comparison to the LED using a conventional structure (indium-tin-oxide as the current spreading layer). In addition, by adjusting the diameter of ZnO nanorod array in use, the light emission of the ZnO nanorod array/p-GaN heterojunction LEDs was enhanced further. This work has great potential applications in solid-state lighting, high performance optoelectronic devices, and so on. 78.60.Fi; 85.60.Jb; 78.67.Lt; 81.10.Dn.

Nonstarch polysaccharides in wheat flour wire-cut cookie making.

PubMed

Guttieri, Mary J; Souza, Edward J; Sneller, Clay

2008-11-26

Nonstarch polysaccharides in wheat flour have significant capacity to affect the processing quality of wheat flour dough and the finished quality of wheat flour products. Most research has focused on the effects of arabinoxylans (AX) in bread making. This study found that water-extractable AX and arabinogalactan peptides can predict variation in pastry wheat quality as captured by the wire-cut cookie model system. The sum of water-extractable AX plus arabinogalactan was highly predictive of cookie spread factor. The combination of cookie spread factor and the ratio of water-extractable arabinose to xylose predicted peak force of the three-point bend test of cookie texture.

Average current is better than peak current as therapeutic dosage for biphasic waveforms in a ventricular fibrillation pig model of cardiac arrest.

PubMed

Chen, Bihua; Yu, Tao; Ristagno, Giuseppe; Quan, Weilun; Li, Yongqin

2014-10-01

Defibrillation current has been shown to be a clinically more relevant dosing unit than energy. However, the effects of average and peak current in determining shock outcome are still undetermined. The aim of this study was to investigate the relationship between average current, peak current and defibrillation success when different biphasic waveforms were employed. Ventricular fibrillation (VF) was electrically induced in 22 domestic male pigs. Animals were then randomized to receive defibrillation using one of two different biphasic waveforms. A grouped up-and-down defibrillation threshold-testing protocol was used to maintain the average success rate of 50% in the neighborhood. In 14 animals (Study A), defibrillations were accomplished with either biphasic truncated exponential (BTE) or rectilinear biphasic waveforms. In eight animals (Study B), shocks were delivered using two BTE waveforms that had identical peak current but different waveform durations. Both average and peak currents were associated with defibrillation success when BTE and rectilinear waveforms were investigated. However, when pathway impedance was less than 90Ω for the BTE waveform, bivariate correlation coefficient was 0.36 (p=0.001) for the average current, but only 0.21 (p=0.06) for the peak current in Study A. In Study B, a high defibrillation success (67.9% vs. 38.8%, p<0.001) was observed when the waveform delivered more average current (14.9±2.1A vs. 13.5±1.7A, p<0.001) while keeping the peak current unchanged. In this porcine model of VF, average current was better than peak current to be an adequate parameter to describe the therapeutic dosage when biphasic defibrillation waveforms were used. The institutional protocol number: P0805. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

[Predicting spread of new pandemic swine-origin influenza A (H1N1) in local mid-size city: evaluation of hospital bed shortage and effectiveness of vaccination].

PubMed

Takeuchi, Shouhei; Kuroda, Yoshiki

2010-01-01

On April 24th, 2009, a new swine-origin influenza A (H1N1) was first reported in Mexico. Japan confirmed cases of the flu on May 9th, and the pandemic in Japan has become full-scale. The Ministry of Health, Labor and Welfare of Japan announced that the first peak of this pandemic was predicted to occur in October, 2009. Therefore, it is most important to predict the progress of this pandemic to be able to use medical resources effectively in Japan. We used a modified susceptible-exposed-infected-recovered (SEIR) model to calculate the number of infected people and hospital bed shortage during this pandemic. In this model, available medical resources were investigated on the basis of four vaccination scenarios. Our model showed that it would take a further six months for the pandemic to peak than was predicted by the Ministry of Health, Labor and Welfare of Japan. Without vaccination, at the peak of the pandemic 23,689 out of 400,000 people would be infected and the hospital bed shortage would reach 7,349 in total. We suggest that mathematical models are strong tools to predict the spread of infectious diseases. According to our model, it is possible to prevent hospital bed shortage by vaccination.

A High Peak Current Source for the CEBAF Injector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yunn, Byung; Sinclair, Charles; Krafft, Geoffrey

1992-07-01

The CEBAF accelerator can drive high power IR and UV FELs, if a high peak current source is added to the existing front end. We present a design for a high peak current injector which is compatible with simultaneous operation of the accelerator for cw nulear physics (NP) beam. The high peak current injector provides 60 A peak current in 2 psec long bunches carrying 120 pC charge at 7.485 MHz. At 10 MeV that beam is combined with 5 MeV NP beam (0.13pC, 2 psec long bunches at 1497 MHz) in an energy combination chicane for simultaneous acceleration inmore » the injector linac. The modifications to the low-energy NP transport are described. Results of optical and beam dynamics calculations for both high peak current and NP beams in combined operation are presented.« less

Generation, and applications of stable, 100-500-MeV, dark-current-free beams, from a laser-wakefield accelerator

NASA Astrophysics Data System (ADS)

Banerjee, Sudeep

2011-10-01

This talk will report the production of high energy, quasi-monoenergetic electron bunches without the low-energy electron background that is typically detected from self-injected laser-wakefield accelerators. These electron bunches are produced when the accelerator is operated in the blowout regime, and the laser and plasma parameters are optimized. High-contrast, high power (30-60 TW) and ultra-short-duration (30 fs) laser pulses are focused onto He-gas-jet targets. The high energy (300-400 MeV) monoenergetic (energy spread < 10%) beams are characterized by 1-4-mrad divergence, pointing stability of 1-2 mrad, and a few-percent shot-to-shot fluctuation of peak energy. The results are scalable: the beam energy can be tuned by appropriate choice of acceleration length, laser power and plasma density. Three-dimensional particle-in-cell simulations show that these electron beams are generated when the accelerator is operated near the self-injection threshold, which suppresses dark current (continuous injection in the first bucket). Suppression of dark current is required to minimize noise, improve the quality of secondary radiation sources, and minimize shielding requirements for high repetition-rate operation. Also reported, is the application of this novel electron-beam source to radiography of dense objects with sub-millimeter spatial resolution. In this case, the energetic electron beam is incident on a 2''-thick steel target with embedded voids, which are detected with image plates. Current progress on the generation of GeV energy electron beams with petawatt peak power laser pulses, from the upgraded DIOCLES laser system, will also be discussed. Work supported by U. S. DOE grants DEFG02-05ER15663, DE-FG02-08ER55000; DARPA grant FA9550-09-1-0009; DTRA grant HDTRA1-11-C-0001 and, DHS grant 2007-DN-007-ER0007-02. The laser is supported by AFOSR contracts FA 9550-08-1-0232, FA9550-07-1-0521.

Electric breakdown during the pulsed current spreading in the sand

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vasilyak, L. M., E-mail: vasilyak@ihed.ras.ru; Vetchinin, S. P.; Panov, V. A.

2016-03-15

Processes of spreading of the pulsed current from spherical electrodes and an electric breakdown in the quartz sand are studied experimentally. When the current density on the electrode exceeds the critical value, a nonlinear reduction occurs in the grounding resistance as a result of sparking in the soil. The critical electric field strengths for ionization and breakdown are determined. The ionization-overheating instability is shown to develop on the electrode, which leads to the current contraction and formation of plasma channels.

47 CFR 87.479 - Harmful interference to radionavigation land stations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... to establish wide-band systems using frequency-hopping spread spectrum techniques in the 960-1215 MHz... spectrum uniformly across the band; (2) The radiated pulse varies from the specified width of 6.4... peak of the JTIDS spectrum as measured in a 300 kHz bandwidth. The JTIDS will be prohibited from...

47 CFR 87.479 - Harmful interference to radionavigation land stations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... to establish wide-band systems using frequency-hopping spread spectrum techniques in the 960-1215 MHz... spectrum uniformly across the band; (2) The radiated pulse varies from the specified width of 6.4... peak of the JTIDS spectrum as measured in a 300 kHz bandwidth. The JTIDS will be prohibited from...

47 CFR 87.479 - Harmful interference to radionavigation land stations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... to establish wide-band systems using frequency-hopping spread spectrum techniques in the 960-1215 MHz... spectrum uniformly across the band; (2) The radiated pulse varies from the specified width of 6.4... peak of the JTIDS spectrum as measured in a 300 kHz bandwidth. The JTIDS will be prohibited from...

Effect of target composition on proton acceleration in ultraintense laser-thin foil interaction

NASA Astrophysics Data System (ADS)

Liu, Qingcao; Liu, Meng; Yu, Tongpu; Ding, Pengji; Liu, Zuoye; Sun, Shaohua; Liu, Xiaoliang; Lu, Xing; Guo, Zeqin; Hu, Bitao

2012-09-01

The interactions of ultraintense circularly polarized laser pulses with a mixed solid target and a double-layer target are studied by two-dimensional particle-in-cell simulations. Different carbon and proton compositions in the targets are used in the simulations. It is shown that the proton acceleration mechanisms in both targets are very sensitive to the ion density ratios between protons and carbon ions. For a mixed solid target, a relatively low proton density gives rise to monoenergetic peaks in the proton energy spectrum while a high proton density leads to a large cut-off energy and wide energy spread. With the increase of the ratio, the so-called directed-Coulomb-explosion becomes dominated over the radiation pressure. Surprisingly, for a double-layer target with a front proton layer and an ultrathin rear carbon layer, a highly monoenergetic proton beam with a peak energy of 1.7 GeV/u, an energy spread of ˜4%, and a divergency angle of 2° can be obtained, which might have diverse applications in medical therepy and proton imaging in future.

Effect of modelling slum populations on influenza spread in Delhi

PubMed Central

Chen, Jiangzhuo; Chu, Shuyu; Chungbaek, Youngyun; Khan, Maleq; Kuhlman, Christopher; Marathe, Achla; Mortveit, Henning; Vullikanti, Anil; Xie, Dawen

2016-01-01

Objectives This research studies the impact of influenza epidemic in the slum and non-slum areas of Delhi, the National Capital Territory of India, by taking proper account of slum demographics and residents’ activities, using a highly resolved social contact network of the 13.8 million residents of Delhi. Methods An SEIR model is used to simulate the spread of influenza on two different synthetic social contact networks of Delhi, one where slums and non-slums are treated the same in terms of their demographics and daily sets of activities and the other, where slum and non-slum regions have different attributes. Results Differences between the epidemic outcomes on the two networks are large. Time-to-peak infection is overestimated by several weeks, and the cumulative infection rate and peak infection rate are underestimated by 10–50%, when slum attributes are ignored. Conclusions Slum populations have a significant effect on influenza transmission in urban areas. Improper specification of slums in large urban regions results in underestimation of infections in the entire population and hence will lead to misguided interventions by policy planners. PMID:27687898

NGA-West2 equations for predicting vertical-component PGA, PGV, and 5%-damped PSA from shallow crustal earthquakes

USGS Publications Warehouse

Stewart, Jonathan P.; Boore, David M.; Seyhan, Emel; Atkinson, Gail M.

2016-01-01

We present ground motion prediction equations (GMPEs) for computing natural log means and standard deviations of vertical-component intensity measures (IMs) for shallow crustal earthquakes in active tectonic regions. The equations were derived from a global database with M 3.0–7.9 events. The functions are similar to those for our horizontal GMPEs. We derive equations for the primary M- and distance-dependence of peak acceleration, peak velocity, and 5%-damped pseudo-spectral accelerations at oscillator periods between 0.01–10 s. We observe pronounced M-dependent geometric spreading and region-dependent anelastic attenuation for high-frequency IMs. We do not observe significant region-dependence in site amplification. Aleatory uncertainty is found to decrease with increasing magnitude; within-event variability is independent of distance. Compared to our horizontal-component GMPEs, attenuation rates are broadly comparable (somewhat slower geometric spreading, faster apparent anelastic attenuation), VS30-scaling is reduced, nonlinear site response is much weaker, within-event variability is comparable, and between-event variability is greater.

Investigating the Implications of a Variable RBE on Proton Dose Fractionation Across a Clinical Pencil Beam Scanned Spread-Out Bragg Peak

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marshall, Thomas I.; Chaudhary, Pankaj; Michaelidesová, Anna

2016-05-01

Purpose: To investigate the clinical implications of a variable relative biological effectiveness (RBE) on proton dose fractionation. Using acute exposures, the current clinical adoption of a generic, constant cell killing RBE has been shown to underestimate the effect of the sharp increase in linear energy transfer (LET) in the distal regions of the spread-out Bragg peak (SOBP). However, experimental data for the impact of dose fractionation in such scenarios are still limited. Methods and Materials: Human fibroblasts (AG01522) at 4 key depth positions on a clinical SOBP of maximum energy 219.65 MeV were subjected to various fractionation regimens with an interfractionmore » period of 24 hours at Proton Therapy Center in Prague, Czech Republic. Cell killing RBE variations were measured using standard clonogenic assays and were further validated using Monte Carlo simulations and parameterized using a linear quadratic formalism. Results: Significant variations in the cell killing RBE for fractionated exposures along the proton dose profile were observed. RBE increased sharply toward the distal position, corresponding to a reduction in cell sparing effectiveness of fractionated proton exposures at higher LET. The effect was more pronounced at smaller doses per fraction. Experimental survival fractions were adequately predicted using a linear quadratic formalism assuming full repair between fractions. Data were also used to validate a parameterized variable RBE model based on linear α parameter response with LET that showed considerable deviations from clinically predicted isoeffective fractionation regimens. Conclusions: The RBE-weighted absorbed dose calculated using the clinically adopted generic RBE of 1.1 significantly underestimates the biological effective dose from variable RBE, particularly in fractionation regimens with low doses per fraction. Coupled with an increase in effective range in fractionated exposures, our study provides an RBE dataset that can be used by the modeling community for the optimization of fractionated proton therapy.« less

Nano-focusing effect simulation of metal film with subwavelength pattern structures

NASA Astrophysics Data System (ADS)

Wei, Dong; Yu, Yue; Li, Dapeng; Wu, Yong; Xin, Zhaowei; Xie, Xingwang; Zhang, Xinyu; Wang, Haiwei; Xie, Changsheng

2018-02-01

Surface plasmon polarizations (SPP) is a nano-scale photon control technology which can converge the spread of oscillation electron driven by incident light. In recent years, SPP has become an advanced research hotspot and has been studied more and more widely. The convergence effect of SPP has extensive applications, such as Schottky barrier detector in which the higher power hotspot, the lower signal-to-noise ratio. In this paper, studies have been done about the interaction of light and matter. Different geometric shapes have been simulated, which were obtained by graphic clipping. Via comparing the power of the hot spot and the minimum location on the transmittance line, we concluded the relationship of the interaction and the structure. It's found that every absorption peak corresponds a mode of LSPP spread. Therefore, we can design figure to control the spread of the SPP, and achieve fantastic goal. Finally, a typical figure with high power hotspot was given.

Universal Broadening of the Light Cone in Low-Temperature Transport

NASA Astrophysics Data System (ADS)

Bertini, Bruno; Piroli, Lorenzo; Calabrese, Pasquale

2018-04-01

We consider the low-temperature transport properties of critical one-dimensional systems that can be described, at equilibrium, by a Luttinger liquid. We focus on the prototypical setting where two semi-infinite chains are prepared in two thermal states at small but different temperatures and suddenly joined together. At large distances x and times t , conformal field theory characterizes the energy transport in terms of a single light cone spreading at the sound velocity v . Energy density and current take different constant values inside the light cone, on its left, and on its right, resulting in a three-step form of the corresponding profiles as a function of ζ =x /t . Here, using a nonlinear Luttinger liquid description, we show that for generic observables this picture is spoiled as soon as a nonlinearity in the spectrum is present. In correspondence of the transition points x /t =±v , a novel universal region emerges at infinite times, whose width is proportional to the temperatures on the two sides. In this region, expectation values have a different temperature dependence and show smooth peaks as a function of ζ . We explicitly compute the universal function describing such peaks. In the specific case of interacting integrable models, our predictions are analytically recovered by the generalized hydrodynamic approach.

Towards highest peak intensities for ultra-short MeV-range ion bunches

NASA Astrophysics Data System (ADS)

Busold, Simon; Schumacher, Dennis; Brabetz, Christian; Jahn, Diana; Kroll, Florian; Deppert, Oliver; Schramm, Ulrich; Cowan, Thomas E.; Blažević, Abel; Bagnoud, Vincent; Roth, Markus

2015-07-01

A laser-driven, multi-MeV-range ion beamline has been installed at the GSI Helmholtz center for heavy ion research. The high-power laser PHELIX drives the very short (picosecond) ion acceleration on μm scale, with energies ranging up to 28.4 MeV for protons in a continuous spectrum. The necessary beam shaping behind the source is accomplished by applying magnetic ion lenses like solenoids and quadrupoles and a radiofrequency cavity. Based on the unique beam properties from the laser-driven source, high-current single bunches could be produced and characterized in a recent experiment: At a central energy of 7.8 MeV, up to 5 × 108 protons could be re-focused in time to a FWHM bunch length of τ = (462 ± 40) ps via phase focusing. The bunches show a moderate energy spread between 10% and 15% (ΔE/E0 at FWHM) and are available at 6 m distance to the source und thus separated from the harsh laser-matter interaction environment. These successful experiments represent the basis for developing novel laser-driven ion beamlines and accessing highest peak intensities for ultra-short MeV-range ion bunches.

Towards highest peak intensities for ultra-short MeV-range ion bunches

PubMed Central

Busold, Simon; Schumacher, Dennis; Brabetz, Christian; Jahn, Diana; Kroll, Florian; Deppert, Oliver; Schramm, Ulrich; Cowan, Thomas E.; Blažević, Abel; Bagnoud, Vincent; Roth, Markus

2015-01-01

A laser-driven, multi-MeV-range ion beamline has been installed at the GSI Helmholtz center for heavy ion research. The high-power laser PHELIX drives the very short (picosecond) ion acceleration on μm scale, with energies ranging up to 28.4 MeV for protons in a continuous spectrum. The necessary beam shaping behind the source is accomplished by applying magnetic ion lenses like solenoids and quadrupoles and a radiofrequency cavity. Based on the unique beam properties from the laser-driven source, high-current single bunches could be produced and characterized in a recent experiment: At a central energy of 7.8 MeV, up to 5 × 108 protons could be re-focused in time to a FWHM bunch length of τ = (462 ± 40) ps via phase focusing. The bunches show a moderate energy spread between 10% and 15% (ΔE/E0 at FWHM) and are available at 6 m distance to the source und thus separated from the harsh laser-matter interaction environment. These successful experiments represent the basis for developing novel laser-driven ion beamlines and accessing highest peak intensities for ultra-short MeV-range ion bunches. PMID:26212024

Predicting the dynamics of local adaptation in invasive species

USDA-ARS?s Scientific Manuscript database

An invasive plant species may restrict its spread to only one habitat, or, after some time, may continue to spread into a different, secondary, habitat. The question of whether evolution is required for an invasive species to spread from one habitat to another is currently hotly debated. In order fo...

An examination of fuel particle heating during fire spread

Treesearch

Jack D. Cohen; Mark A. Finney

2010-01-01

Recent high intensity wildfires and our demonstrated inability to control extreme fire behavior suggest a need for alternative approaches for preventing wildfire disasters. Current fire spread models are not sufficiently based on a basic understanding of fire spread processes to provide more effective management alternatives. An experimental and theoretical approach...

Masked Priming Effects in Aphasia: Evidence of Altered Automatic Spreading Activation

ERIC Educational Resources Information Center

Silkes, JoAnn P.; Rogers, Margaret A.

2012-01-01

Purpose: Previous research has suggested that impairments of automatic spreading activation may underlie some aphasic language deficits. The current study further investigated the status of automatic spreading activation in individuals with aphasia as compared with typical adults. Method: Participants were 21 individuals with aphasia (12 fluent, 9…

Tissue resistivities determine the current flow in the cochlea.

PubMed

Micco, Alan Gerard; Richter, Claus-Peter

2006-10-01

In individuals with severe to profound hearing loss, cochlear implants bypass normal inner ear function by applying electrical current directly into the cochlea, thereby stimulating cochlear nerve fibers. Stimulating discrete populations of spiral ganglion cells in cochlear implant users' ears is similar to the encoding of small acoustic frequency bands in a normal-hearing person's ear. Thus, spiral ganglion cells stimulated by an electrode convey the information contained by a small acoustic frequency band. Problems that refer to the current spread and subsequent nonselective stimulation of spiral ganglion cells in the cochlea are reviewed. Cochlear anatomy and tissue properties determine the current path in the cochlea. Current spreads largely via scala tympani and across turns. While most of the current leaves the cochlea via the modiolus, the facial canal and the round window constitute additional natural escape paths for the current from the cochlea. Moreover, degenerative processes change tissue resistivities and thus may affect current spread in the cochlea. Electrode design and coding strategies may result in more spatial stimulation of spiral ganglion cells, resulting in a better performance of the electrode-tissue interface.

Experimental study of heating scheme effect on the inner divertor power footprint widths in EAST lower single null discharges

NASA Astrophysics Data System (ADS)

Deng, G. Z.; Xu, J. C.; Liu, X.; Liu, X. J.; Liu, J. B.; Zhang, H.; Liu, S. C.; Chen, L.; Yan, N.; Feng, W.; Liu, H.; Xia, T. Y.; Zhang, B.; Shao, L. M.; Ming, T. F.; Xu, G. S.; Guo, H. Y.; Xu, X. Q.; Gao, X.; Wang, L.

2018-04-01

A comprehensive work of the effects of plasma current and heating schemes on divertor power footprint widths is carried out in the experimental advanced superconducting tokamak (EAST). The divertor power footprint widths, i.e., the scrape-off layer heat flux decay length λ q and the heat spreading S, are crucial physical and engineering parameters for fusion reactors. Strong inverse scaling of λ q and S with plasma current have been demonstrated for both neutral beam (NB) and lower hybrid wave (LHW) heated L-mode and H-mode plasmas at the inner divertor target. For plasmas heated by the combination of the two kinds of auxiliary heating schemes (NB and LHW), the divertor power widths tend to be larger in plasmas with higher ratio of LHW power. Comparison between experimental heat flux profiles at outer mid-plane (OMP) and divertor target for NB heated and LHW heated L-mode plasmas reveals that the magnetic topology changes induced by LHW may be the main reason to the wider divertor power widths in LHW heated discharges. The effect of heating schemes on divertor peak heat flux has also been investigated, and it is found that LHW heated discharges tend to have a lower divertor peak heat flux compared with NB heated discharges under similar input power. All these findings seem to suggest that plasmas with LHW auxiliary heating scheme are better heat exhaust scenarios for fusion reactors and should be the priorities for the design of next-step fusion reactors like China Fusion Engineering Test Reactor.

Parameters of triggered-lightning flashes in Florida and Alabama

NASA Astrophysics Data System (ADS)

Fisher, R. J.; Schnetzer, G. H.; Thottappillil, R.; Rakov, V. A.; Uman, M. A.; Goldberg, J. D.

1993-12-01

Channel base currents from triggered lightning were measured at the NASA Kennedy Space Center, Florida, during summer 1990 and at Fort McClellan, Alabama, during summer 1991. Additionally, 16-mm cinematic records with 3- or 5-ms resolution were obtained for all flashes, and streak camera records were obtained for three of the Florida flashes. The 17 flashes analyzed here contained 69 strokes, all lowering negative charge from cloud to ground. Statistics on interstroke interval, no-current interstroke interval, total stroke duration, total stroke charge, total stroke action integral (∫ i2dt), return stroke current wave front characteristics, time to half peak value, and return stroke peak current are presented. Return stroke current pulses, characterized by rise times of the order of a few microseconds or less and peak values in the range of 4 to 38 kA, were found not to occur until after any preceding current at the bottom of the lightning channel fell below the noise level of less than 2 A. Current pulses associated with M components, characterized by slower rise times (typically tens to hundreds of microseconds) and peak values generally smaller than those of the return stroke pulses, occurred during established channel current flow of some tens to some hundreds of amperes. A relatively strong positive correlation was found between return stroke current average rate of rise and current peak. There was essentially no correlation between return stroke current peak and 10-90% rise time or between return stroke peak and the width of the current waveform at half of its peak value. Parameters of the lightning flashes triggered in Florida and Alabama are similar to each other but are different from those of triggered lightning recorded in New Mexico during the 1981 Thunderstorm Research International Program. Continuing currents that follow return stroke current peaks and last for more than 10 ms exhibit a variety of wave shapes that we have subdivided into four categories. All such continuing currents appear to start with a current pulse presumably associated with an M component. A brief summary of lightning parameters important for lightning protection, in a form convenient for practical use, is presented in an appendix.

Dominance of layer-specific microvessel dilation in contrast-enhanced high-resolution fMRI: Comparison between hemodynamic spread and vascular architecture with CLARITY.

PubMed

Poplawsky, Alexander John; Fukuda, Mitsuhiro; Kang, Bok-Man; Kim, Jae Hwan; Suh, Minah; Kim, Seong-Gi

2017-08-16

Contrast-enhanced cerebral blood volume-weighted (CBVw) fMRI response peaks are specific to the layer of evoked synaptic activity (Poplawsky et al., 2015), but the spatial resolution limit of CBVw fMRI is unknown. In this study, we measured the laminar spread of the CBVw fMRI evoked response in the external plexiform layer (EPL, 265 ± 65 μm anatomical thickness, mean ± SD, n = 30 locations from 5 rats) of the rat olfactory bulb during electrical stimulation of the lateral olfactory tract and examined its potential vascular source. First, we obtained the evoked CBVw fMRI responses with a 55 × 55 μm 2 in-plane resolution and a 500-μm thickness at 9.4 T, and found that the fMRI signal peaked predominantly in the inner half of EPL (136 ± 54 μm anatomical thickness). The mean full-width at half-maximum of these fMRI peaks was 347 ± 102 μm and the functional spread was approximately 100 or 200 μm when the effects of the laminar thicknesses of EPL or inner EPL were removed, respectively. Second, we visualized the vascular architecture of EPL from a different rat using a Clear Lipid-exchanged Anatomically Rigid Imaging/immunostaining-compatible Tissue hYdrogel (CLARITY)-based tissue preparation method and confocal microscopy. Microvascular segments with an outer diameter of <11 μm accounted for 64.3% of the total vascular volume within EPL and had a mean segment length of 55 ± 40 μm (n = 472). Additionally, vessels that crossed the EPL border had a mean segment length outside of EPL equal to 73 ± 61 μm (n = 28), which is comparable to half of the functional spread (50-100 μm). Therefore, we conclude that dilation of these microvessels, including capillaries, likely dominate the CBVw fMRI response and that the biological limit of the fMRI spatial resolution is approximately the average length of 1-2 microvessel segments, which may be sufficient for examining sublaminar circuits. Copyright © 2017 Elsevier Inc. All rights reserved.

Reduction in spread of excitation from current focusing at multiple cochlear locations in cochlear implant users.

PubMed

Padilla, Monica; Landsberger, David M

2016-03-01

Channel interaction from a broad spread of excitation is likely to be a limiting factor in performance by cochlear implant users. Although partial tripolar stimulation has been shown to reduce spread of excitation, the magnitude of the reduction is highly variable across subjects. Because the reduction in spread of excitation is typically only measured at one electrode for a given subject, the degree of variability across cochlear locations is unknown. The first goal of the present study was to determine if the reduction in spread of excitation observed from partial tripolar current focusing systematically varies across the cochlea. The second goal was to measure the variability in reduction of spread of excitation relative to monopolar stimulation across the cochlea. The third goal was to expand upon previous results that suggest that scaling of verbal descriptors can be used to predict the reduction in spread of excitation, by increasing the limited number of sites previously evaluated and verify the relationships remain with the larger dataset. The spread of excitation for monopolar and partial tripolar stimulation was measured at 5 cochlear locations using a psychophysical forward masking task. Results of the present study suggest that although partial tripolar stimulation typically reduces spread of excitation, the degree of reduction in spread of excitation was found to be highly variable and no effect of cochlear location was found. Additionally, subjective scaling of certain verbal descriptors (Clean/Dirty, Pure/Noisy) correlated with the reduction in spread of excitation suggesting sound quality scaling might be used as a quick clinical estimate of channels providing a reduction in spread of excitation. This quick scaling technique might help clinicians determine which patients would be most likely to benefit from a focused strategy. Copyright © 2016 Elsevier B.V. All rights reserved.

Reduction in Spread of Excitation from Current Focusing at Multiple Cochlear Locations in Cochlear Implant Users

PubMed Central

Padilla, Monica; Landsberger, David M.

2016-01-01

Channel interaction from a broad spread of excitation is likely to be a limiting factor in performance by cochlear implant users. Although partial tripolar stimulation has been shown to reduce spread of excitation, the magnitude of the reduction is highly variable across subjects. Because the reduction in spread of excitation is typically only measured at one electrode for a given subject, the degree of variability across cochlear locations is unknown. The first goal of the present study was to determine if the reduction in spread of excitation observed from partial tripolar current focusing systematically varies across the cochlea. The second goal was to measure the variability in reduction of spread of excitation relative to monopolar stimulation across the cochlea. The third goal was to expand upon previous results that suggest that scaling of verbal descriptors can be used to predict the reduction in spread of excitation, by increasing the limited number of sites previously evaluated and verify the relationships remain with the larger dataset. The spread of excitation for monopolar and partial tripolar stimulation was measured at 5 cochlear locations using a psychophysical forward masking task. Results of the present study suggest that although partial tripolar stimulation typically reduces spread of excitation, the degree of reduction in spread of excitation was found to be highly variable and no effect of cochlear location was found. Additionally, subjective scaling of certain verbal descriptors (Clean/Dirty, Pure/Noisy) correlated with the reduction in spread of excitation suggesting sound quality scaling might be used as a quick clinical estimate of channels providing a reduction in spread of excitation. This quick scaling technique might help clinicians determine which patients would be most likely to benefit from a focused strategy. PMID:26778546

Molecular phylogeography of canine distemper virus: Geographic origin and global spreading.

PubMed

Panzera, Yanina; Sarute, Nicolás; Iraola, Gregorio; Hernández, Martín; Pérez, Ruben

2015-11-01

Canine distemper virus (CDV) (Paramyxoviridae-Morbillivirus) is a worldwide spread virus causing a fatal systemic disease in a broad range of carnivore hosts. In this study we performed Bayesian inferences using 208 full-length hemagglutinin gene nucleotide sequences isolated in 16 countries during 37 years (1975-2011). The estimated time to the most recent common ancestor suggested that current CDV strains emerged in the United States in the 1880s. This ancestor diversified through time into two ancestral clades, the current America 1 lineage that recently spread to Asia, and other ancestral clade that diversified and spread worldwide to originate the remaining eight lineages characterized to date. The spreading of CDV was characterized by several migratory events with posterior local differentiation, and expansion of the virus host range. A significant genetic flow between domestic and wildlife hosts is displayed; being domestic hosts the main viral reservoirs worldwide. This study is an extensive and integrative description of spatio/temporal population dynamics of CDV lineages that provides a novel evolutionary paradigm about the origin and dissemination of the current strains of the virus. Copyright © 2015 Elsevier Inc. All rights reserved.

The current state of knowledge on operational sanitation measures to lower risk of Phytophthora ramorum spread and the need for further study

Treesearch

Yana Valachovic; Dave Rizzo; Brendan Twieg

2013-01-01

We are working to evaluate risks associated with human spread of the sudden oak death (SOD) pathogen, Phytophthora ramorum, to currently uninfested areas in California. Port-Orford-cedar (Chamaecyparis lawsoniana (A. Murray) Parl.) root disease (POC RD), caused by Phytophthora lateralis, has brought...

Fire spread in chaparral -"go or no-go?"

Treesearch

D.R. Weise; Xiangyang Zhou; Lulu Sun; Shankar Mahalingam

2005-01-01

Current fire models are designed to model the spread of a linear fire front in dead, small-diameter fuels. Fires in predominantly living vegetation account for a large proportion of annual burned area nationally. Prescribed burning is used to manage living fuels; however, prescribed burning is currently conducted under conditions that result in marginal burning. We do...

Impact of Network Activity on the Spread of Infectious Diseases through the German Pig Trade Network.

PubMed

Lebl, Karin; Lentz, Hartmut H K; Pinior, Beate; Selhorst, Thomas

2016-01-01

The trade of livestock is an important and growing economic sector, but it is also a major factor in the spread of diseases. The spreading of diseases in a trade network is likely to be influenced by how often existing trade connections are active. The activity α is defined as the mean frequency of occurrences of existing trade links, thus 0 < α ≤ 1. The observed German pig trade network had an activity of α = 0.11, thus each existing trade connection between two farms was, on average, active at about 10% of the time during the observation period 2008-2009. The aim of this study is to analyze how changes in the activity level of the German pig trade network influence the probability of disease outbreaks, size, and duration of epidemics for different disease transmission probabilities. Thus, we want to investigate the question, whether it makes a difference for a hypothetical spread of an animal disease to transport many animals at the same time or few animals at many times. A SIR model was used to simulate the spread of a disease within the German pig trade network. Our results show that for transmission probabilities <1, the outbreak probability increases in the case of a decreased frequency of animal transports, peaking range of α from 0.05 to 0.1. However, for the final outbreak size, we find that a threshold exists such that finite outbreaks occur only above a critical value of α, which is ~0.1, and therefore in proximity of the observed activity level. Thus, although the outbreak probability increased when decreasing α, these outbreaks affect only a small number of farms. The duration of the epidemic peaks at an activity level in the range of α = 0.2-0.3. Additionally, the results of our simulations show that even small changes in the activity level of the German pig trade network would have dramatic effects on outbreak probability, outbreak size, and epidemic duration. Thus, we can conclude and recommend that the network activity is an important aspect, which should be taken into account when modeling the spread of diseases within trade networks.

Climate Change and Aedes Vectors: 21st Century Projections for Dengue Transmission in Europe.

PubMed

Liu-Helmersson, Jing; Quam, Mikkel; Wilder-Smith, Annelies; Stenlund, Hans; Ebi, Kristie; Massad, Eduardo; Rocklöv, Joacim

2016-05-01

Warming temperatures may increase the geographic spread of vector-borne diseases into temperate areas. Although a tropical mosquito-borne viral disease, a dengue outbreak occurred in Madeira, Portugal, in 2012; the first in Europe since 1920s. This outbreak emphasizes the potential for dengue re-emergence in Europe given changing climates. We present estimates of dengue epidemic potential using vectorial capacity (VC) based on historic and projected temperature (1901-2099). VC indicates the vectors' ability to spread disease among humans. We calculated temperature-dependent VC for Europe, highlighting 10 European cities and three non-European reference cities. Compared with the tropics, Europe shows pronounced seasonality and geographical heterogeneity. Although low, VC during summer is currently sufficient for dengue outbreaks in Southern Europe to commence-if sufficient vector populations (either Ae. aegypti and Ae. albopictus) were active and virus were introduced. Under various climate change scenarios, the seasonal peak and time window for dengue epidemic potential increases during the 21st century. Our study maps dengue epidemic potential in Europe and identifies seasonal time windows when major cities are most conducive for dengue transmission from 1901 to 2099. Our findings illustrate, that besides vector control, mitigating greenhouse gas emissions crucially reduces the future epidemic potential of dengue in Europe. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

Using landscape epidemiological models to understand the distribution of chronic wasting disease in the Midwestern USA

USGS Publications Warehouse

Robinson, Stacie J.; Samuel, Michael D.; Rolley, Robert E.; Shelton, Paul

2013-01-01

Animal movement across the landscape plays a critical role in the ecology of infectious wildlife diseases. Dispersing animals can spread pathogens between infected areas and naïve populations. While tracking free-ranging animals over the geographic scales relevant to landscape-level disease management is challenging, landscape features that influence gene flow among wildlife populations may also influence the contact rates and disease spread between populations. We used spatial diffusion and barriers to white-tailed deer gene flow, identified through landscape genetics, to model the distribution of chronic wasting disease (CWD) in the infected region of southern Wisconsin and northern Illinois, USA. Our generalized linear model showed that risk of CWD infection declined exponentially with distance from current outbreaks, and inclusion of gene flow barriers dramatically improved fit and predictive power of the model. Our results indicate that CWD is spreading across the Midwestern landscape from these two endemic foci, but spread is strongly influenced by highways and rivers that also reduce deer gene flow. We used our model to plot a risk map, providing important information for CWD management by identifying likely routes of disease spread and providing a tool for prioritizing disease monitoring and containment efforts. The current analysis may serve as a framework for modeling future disease risk drawing on genetic information to investigate barriers to spread and extending management and monitoring beyond currently affected regions.

Degradation of the Bragg peak due to inhomogeneities.

PubMed

Urie, M; Goitein, M; Holley, W R; Chen, G T

1986-01-01

The rapid fall-off of dose at the end of range of heavy charged particle beams has the potential in therapeutic applications of sparing critical structures just distal to the target volume. Here we explored the effects of highly inhomogeneous regions on this desirable depth-dose characteristic. The proton depth-dose distribution behind a lucite-air interface parallel to the beam was bimodal, indicating the presence of two groups of protons with different residual ranges, creating a step-like depth-dose distribution at the end of range. The residual ranges became more spread out as the interface was angled at 3 degrees, and still more at 6 degrees, to the direction of the beam. A second experiment showed little significant effect on the distal depth-dose of protons having passed through a mosaic of teflon and lucite. Anatomic studies demonstrated significant effects of complex fine inhomogeneities on the end of range characteristics. Monoenergetic protons passing through the petrous ridges and mastoid air cells in the base of skull showed a dramatic degradation of the distal Bragg peak. In beams with spread out Bragg peaks passing through regions of the base of skull, the distal fall-off from 90 to 20% dose was increased from its nominal 6 to well over 32 mm. Heavy ions showed a corresponding degradation in their ends of range. In the worst case in the base of skull region, a monoenergetic neon beam showed a broadening of the full width at half maximum of the Bragg peak to over 15 mm (compared with 4 mm in a homogeneous unit density medium). A similar effect was found with carbon ions in the abdomen, where the full width at half maximum of the Bragg peak (nominally 5.5 mm) was found to be greater than 25 mm behind gas-soft-tissue interfaces. We address the implications of these data for dose computation with heavy charged particles.

Uncertainty in the Himalayan energy-water nexus: estimating regional exposure to glacial lake outburst floods

NASA Astrophysics Data System (ADS)

Schwanghart, Wolfgang; Worni, Raphael; Huggel, Christian; Stoffel, Markus; Korup, Oliver

2016-07-01

Himalayan water resources attract a rapidly growing number of hydroelectric power projects (HPP) to satisfy Asia’s soaring energy demands. Yet HPP operating or planned in steep, glacier-fed mountain rivers face hazards of glacial lake outburst floods (GLOFs) that can damage hydropower infrastructure, alter water and sediment yields, and compromise livelihoods downstream. Detailed appraisals of such GLOF hazards are limited to case studies, however, and a more comprehensive, systematic analysis remains elusive. To this end we estimate the regional exposure of 257 Himalayan HPP to GLOFs, using a flood-wave propagation model fed by Monte Carlo-derived outburst volumes of >2300 glacial lakes. We interpret the spread of thus modeled peak discharges as a predictive uncertainty that arises mainly from outburst volumes and dam-breach rates that are difficult to assess before dams fail. With 66% of sampled HPP are on potential GLOF tracks, up to one third of these HPP could experience GLOF discharges well above local design floods, as hydropower development continues to seek higher sites closer to glacial lakes. We compute that this systematic push of HPP into headwaters effectively doubles the uncertainty about GLOF peak discharge in these locations. Peak discharges farther downstream, in contrast, are easier to predict because GLOF waves attenuate rapidly. Considering this systematic pattern of regional GLOF exposure might aid the site selection of future Himalayan HPP. Our method can augment, and help to regularly update, current hazard assessments, given that global warming is likely changing the number and size of Himalayan meltwater lakes.

Gravitational spreading of steep-sided ridges ("sackung") in Western United States

USGS Publications Warehouse

Radbruch-Hall, D. H.; Varnes, D.J.; Savage, W.Z.

1976-01-01

Large-scale gravitational spreading and movement along fractures of steep-sided ridges in the mountainous areas of the western United States are characterized by linear fissures, trenches, and uphill-facing scarps on tops and sides of ridges. Spreading appears to take place by movement along disconnected planes and/or by slow plastic deformation of a rock mass. In some places, valleyward squeezing out of weak shales overlain by rigid rocks causes extensional fracturing and outward movement of the rigid layers, as illustrated by extension of two laccoliths overlying Mancos Shale, one at Dolores Peak and another at Crested Butte in western Colorado. Gravitational forces acting on a ridge of more homogeneous material causes tensional spreading of the ridge parallel to its long axis, for example in fractured granitic rock north of Mt. Massive in central Colorado, where a survey course has been established to monitor the movement. Recognition and understanding of these large-scale gravitational features and the mechanism that causes them are pertinent to site selection and design of engineering structures in high mountains. If fractures extend to considerable depth and if movement is continuing, engineering structures in valleys or tunnels through the spreading ridges could be damaged. ?? 1976 International Association of Engineering Geology.

Use of a spread sheet to calculate the current-density distribution produced in human and rat models by low-frequency electric fields.

PubMed

Hart, F X

1990-01-01

The current-density distribution produced inside irregularly shaped, homogeneous human and rat models by low-frequency electric fields is obtained by a two-stage finite-difference procedure. In the first stage the model is assumed to be equipotential. Laplace's equation is solved by iteration in the external region to obtain the capacitive-current densities at the model's surface elements. These values then provide the boundary conditions for the second-stage relaxation solution, which yields the internal current-density distribution. Calculations were performed with the Excel spread-sheet program on a Macintosh-II microcomputer. A spread sheet is a two-dimensional array of cells. Each cell of the sheet can represent a square element of space. Equations relating the values of the cells can represent the relationships between the potentials in the corresponding spatial elements. Extension to three dimensions is readily made. Good agreement was obtained with current densities measured on human models with both, one, or no legs grounded and on rat models in four different grounding configurations. The results also compared well with predictions of more sophisticated numerical analyses. Spread sheets can provide an inexpensive and relatively simple means to perform good, approximate dosimetric calculations on irregularly shaped objects.

Resonant tunneling with high peak to valley current ratio in SiO{sub 2}/nc-Si/SiO{sub 2} multi-layers at room temperature

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, D. Y., E-mail: cdy7659@126.com; Nanjing University of posts and Telecommunications, Nanjing 210046; Sun, Y.

We have investigated carrier transport in SiO{sub 2}/nc-Si/SiO{sub 2} multi-layers by room temperature current-voltage measurements. Resonant tunneling signatures accompanied by current peaks are observed. Carrier transport in the multi-layers were analyzed by plots of ln(I/V{sup 2}) as a function of 1/V and ln(I) as a function of V{sup 1/2}. Results suggest that besides films quality, nc-Si and barrier sub-layer thicknesses are important parameters that restrict carrier transport. When thicknesses are both small, direct tunneling dominates carrier transport, resonant tunneling occurs only at certain voltages and multi-resonant tunneling related current peaks can be observed but with peak to valley current ratiomore » (PVCR) values smaller than 1.5. When barrier thickness is increased, trap-related and even high field related tunneling is excited, causing that multi-current peaks cannot be observed clearly, only one current peak with higher PVCR value of 7.7 can be observed. While if the thickness of nc-Si is large enough, quantum confinement is not so strong, a broad current peak with PVCR value as high as 60 can be measured, which may be due to small energy difference between the splitting energy levels in the quantum dots of nc-Si. Size distribution in a wide range may cause un-controllability of the peak voltages.« less

Variability metrics in Josephson Junction fabrication for Quantum Computing circuits

NASA Astrophysics Data System (ADS)

Rosenblatt, Sami; Hertzberg, Jared; Brink, Markus; Chow, Jerry; Gambetta, Jay; Leng, Zhaoqi; Houck, Andrew; Nelson, J. J.; Plourde, Britton; Wu, Xian; Lake, Russell; Shainline, Jeff; Pappas, David; Patel, Umeshkumar; McDermott, Robert

Multi-qubit gates depend on the relative frequencies of the qubits. To reliably build multi-qubit devices therefore requires careful fabrication of Josephson junctions in order to precisely set their critical currents. The Ambegaokar-Baratoff relation between tunnel conductance and critical current implies a correlation between qubit frequency spread and tunnel junction resistance spread. Here we discuss measurement of large numbers of tunnel junctions to assess these resistance spreads, which can exceed 5% of mean resistance. With the goal of minimizing these spreads, we investigate process parameters such as lithographic junction area, evaporation and masking scheme, oxidation conditions, and substrate choice, as well as test environment, design and setup. In addition, trends of junction resistance with temperature are compared with theoretical models for further insights into process and test variability.

Potential for epidemic take-off from the primary outbreak farm via livestock movements

PubMed Central

2011-01-01

Background We consider the potential for infection to spread in a farm population from the primary outbreak farm via livestock movements prior to disease detection. We analyse how this depends on the time of the year infection occurs, the species transmitting, the length of infectious period on the primary outbreak farm, location of the primary outbreak, and whether a livestock market becomes involved. We consider short infectious periods of 1 week, 2 weeks and 4 weeks, characteristic of acute contagious livestock diseases. The analysis is based on farms in Scotland from 1 January 2003 to 31 July 2007. Results The proportion of primary outbreaks from which an acute contagious disease would spread via movement of livestock is generally low, but exhibits distinct annual cyclicity with peaks in May and August. The distance that livestock are moved varies similarly: at the time of the year when the potential for spread via movements is highest, the geographical spread via movements is largest. The seasonal patterns for cattle differ from those for sheep whilst there is no obvious seasonality for pigs. When spread via movements does occur, there is a high risk of infection reaching a livestock market; infection of markets can amplify disease spread. The proportion of primary outbreaks that would spread infection via livestock movements varies significantly between geographical regions. Conclusions In this paper we introduce a set-up for analysis of movement data that allows for a generalized assessment of the risk associated with infection spreading from a primary outbreak farm via livestock movements, applying this to Scotland, we assess how this risk depends upon the time of the year, species transmitting, location of the farm and other factors. PMID:22115121

Correlates of spreading depolarization in human scalp electroencephalography

PubMed Central

Drenckhahn, Christoph; Winkler, Maren K. L.; Major, Sebastian; Scheel, Michael; Kang, Eun-Jeung; Pinczolits, Alexandra; Grozea, Cristian; Hartings, Jed A.; Woitzik, Johannes

2012-01-01

It has been known for decades that suppression of spontaneous scalp electroencephalographic activity occurs during ischaemia. Trend analysis for such suppression was found useful for intraoperative monitoring during carotid endarterectomy, or as a screening tool to detect delayed cerebral ischaemia after aneurismal subarachnoid haemorrhage. Nevertheless, pathogenesis of such suppression of activity has remained unclear. In five patients with aneurismal subarachnoid haemorrhage and four patients with decompressive hemicraniectomy after malignant hemispheric stroke due to middle cerebral artery occlusion, we here performed simultaneously full-band direct and alternating current electroencephalography at the scalp and direct and alternating current electrocorticography at the cortical surface. After subarachnoid haemorrhage, 275 slow potential changes, identifying spreading depolarizations, were recorded electrocorticographically over 694 h. Visual inspection of time-compressed scalp electroencephalography identified 193 (70.2%) slow potential changes [amplitude: −272 (−174, −375) µV (median quartiles), duration: 5.4 (4.0, 7.1) min, electrocorticography–electroencephalography delay: 1.8 (0.8, 3.5) min]. Intervals between successive spreading depolarizations were significantly shorter for depolarizations with electroencephalographically identified slow potential change [33.0 (27.0, 76.5) versus 53.0 (28.0, 130.5) min, P = 0.009]. Electroencephalography was thus more likely to display slow potential changes of clustered than isolated spreading depolarizations. In contrast to electrocorticography, no spread of electroencephalographic slow potential changes was seen, presumably due to superposition of volume-conducted electroencephalographic signals from widespread cortical generators. In two of five patients with subarachnoid haemorrhage, serial magnetic resonance imaging revealed large delayed infarcts at the recording site, while electrocorticography showed clusters of spreading depolarizations with persistent depression of spontaneous activity. Alternating current electroencephalography similarly displayed persistent depression of spontaneous activity, and direct current electroencephalography slow potential changes riding on a shallow negative ultraslow potential. Isolated spreading depolarizations with depression of both spontaneous electrocorticographic and electroencephalographic activity displayed significantly longer intervals between successive spreading depolarizations than isolated depolarizations with only depression of electrocorticographic activity [44.0 (28.0, 132.0) min, n = 96, versus 30.0 (26.5, 51.5) min, n = 109, P = 0.001]. This suggests fusion of electroencephalographic depression periods at high depolarization frequency. No propagation of electroencephalographic depression was seen between scalp electrodes. Durations/magnitudes of isolated electroencephalographic and corresponding electrocorticographic depression periods correlated significantly. Fewer spreading depolarizations were recorded in patients with malignant hemispheric stroke but characteristics were similar to those after subarachnoid haemorrhage. In conclusion, spreading depolarizations and depressions of spontaneous activity display correlates in time-compressed human scalp direct and alternating current electroencephalography that may serve for their non-invasive detection. PMID:22366798

Electromagnetic pulse-induced current measurement device

NASA Astrophysics Data System (ADS)

Gandhi, Om P.; Chen, Jin Y.

1991-08-01

To develop safety guidelines for exposure to high fields associated with an electromagnetic pulse (EMP), it is necessary to devise techniques that would measure the peak current induced in the human body. The main focus of this project was to design, fabricate, and test a portable, self-contained stand-on device that would measure and hold the peak current and the integrated change Q. The design specifications of the EMP-Induced Current Measurement Device are as follows: rise time of the current pulse, 5 ns; peak current, 20-600 A; charge Q, 0-20 microcoulombs. The device uses a stand-on parallel-plate bilayer sensor and fast high-frequency circuit that are well-shielded against spurious responses to high incident fields. Since the polarity of the incident peak electric field of the EMP may be either positive or negative, the induced peak current can also be positive or negative. Therefore, the device is designed to respond to either of these polarities and measure and hold both the peak current and the integrated charge which are simultaneously displayed on two separate 3-1/2 digit displays. The prototype device has been preliminarily tested with the EMP's generated at the Air Force Weapons Laboratory (ALECS facility) at Kirtland AFB, New Mexico.

Optical monitoring of ion beam Y-Ba-Cu-O sputtering

NASA Astrophysics Data System (ADS)

Klein, J. D.; Yen, A.

1990-11-01

The emission spectra resulting from ion beam sputtering a Y-Ba-Cu-O target were observed as a function of beam voltage and beam current. The spectra were relatively clean with several peaks readily attributed to each of Y, Ba, and Ar. Monitoring of copper and oxygen was more difficult with a single CuO peak and one O peak evident. The intensities of the cation peaks were linear with respect to beam voltage above 400 V. Since target current was found not to be directly proportional to beam current, target power was defined as the product of beam voltage and target current. The response of cation peak height to changes in target power was linear and similar for variations of either beam voltage or target current.

RR-Interval variance of electrocardiogram for atrial fibrillation detection

NASA Astrophysics Data System (ADS)

Nuryani, N.; Solikhah, M.; Nugoho, A. S.; Afdala, A.; Anzihory, E.

2016-11-01

Atrial fibrillation is a serious heart problem originated from the upper chamber of the heart. The common indication of atrial fibrillation is irregularity of R peak-to-R-peak time interval, which is shortly called RR interval. The irregularity could be represented using variance or spread of RR interval. This article presents a system to detect atrial fibrillation using variances. Using clinical data of patients with atrial fibrillation attack, it is shown that the variance of electrocardiographic RR interval are higher during atrial fibrillation, compared to the normal one. Utilizing a simple detection technique and variances of RR intervals, we find a good performance of atrial fibrillation detection.

Geographic and temporal trends in influenzalike illness, Japan, 1992-1999.

PubMed

Sakai, Takatsugu; Suzuki, Hiroshi; Sasaki, Asami; Saito, Reiko; Tanabe, Naohito; Taniguchi, Kiyosu

2004-10-01

From 1992 to 1999, we analyzed >2.5 million cases of influenzalike illness (ILI). Nationwide influenza epidemics generally lasted 3-4 months in winter. Kriging analysis, which illustrates geographic movement, showed that the starting areas of peak ILI activity were mostly found in western Japan. Two spreading patterns, monotonous and multitonous, were observed. Monotonous patterns in two seasons featured peak ILI activity that covered all of Japan within 3 to 5 weeks in larger epidemics with new antigenic variants of A/H3N2. Multitonous patterns, observed in the other five seasons, featured peak ILI activity within 12 to 15 weeks in small epidemics without new variants. Applying the kriging method allowed better visualization and understanding of spatiotemporal trends in seasonal ILI activity. This method will likely be an important tool for future influenza surveillance in Japan.

Silicon-Based Quantum MOS Technology Development

DTIC Science & Technology

2000-03-07

resonant interband tunnel diodes were demonstrated with peak current density greater than 104 A/cm2; peak-to-valley current ratio exceeding 2 was...photon emission reduce the peak-to-valley current ratio and device performance. Therefore, interband tunnel devices should be more resilient to...Comparison of bipolar interband tunnel and optical devices: (a) Esaki diode biased into the valley current region and (b) optical light emitter. The Esaki

Thermal power and heat energy of cloud-to-ground lightning process

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Xuejuan; Yuan, Ping; Xue, Simin

2016-07-15

A cloud-to-ground lightning flash with nine return strokes has been recorded using a high speed slitless spectrograph and a system composed of a fast antenna and a slow antenna. Based on the spectral data and the synchronous electric field changes that were caused by the lightning, the electrical conductivity, the channel radii, the resistance per unit length, the peak current, the thermal power at the instant of peak current, and the heat energy per unit length during the first 5 μs in the discharge channel have all been calculated. The results indicate that the channel radii have linear relationships with themore » peak current. The thermal power at the peak current time increases with increasing resistance, but exponential decays with the square of the peak current.« less

Slow the Spread: a national program to manage the gypsy moth

Treesearch

Patrick C. Tobin; Laura M. Blackburn

2007-01-01

The gypsy moth is a destructive, nonindigenous pest of forest, shade, and fruit trees that was introduced into the United States in 1869, and is currently established throughout the Northeast and upper Midwest. The Slow the Spread Program is a regional integrated pest management strategy that aims to minimize the rate of gypsy moth spread into uninfested areas. The...

Applying fire spread simulators in New Zealand and Australia: Results from an international seminar

Treesearch

Tonja Opperman; Jim Gould; Mark Finney; Cordy Tymstra

2006-01-01

There is currently no spatial wildfire spread and growth simulation model used commonly across New Zealand or Australia. Fire management decision-making would be enhanced through the use of spatial fire simulators. Various groups from around the world met in January 2006 to evaluate the applicability of different spatial fire spread applications for common use in both...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fischer, W.; Gu, X.; Altinbas, Z.

Head-on beam-beam compensation has been implemented in the Relativistic Heavy Ion Collider (RHIC) in order to increase the luminosity delivered to the experiments. We discuss the principle of combining a lattice for resonance driving term compensation and an electron lens for tune spread compensation. We describe the electron lens technology and its operational use. As of this date the implemented compensation scheme approximately doubled the peak and average luminosities.

Monitoring the spread of myxoma virus in rabbit Oryctolagus cuniculus populations on the southern tablelands of New South Wales, Australia. I. Natural occurrence of myxomatosis.

PubMed Central

Merchant, J. C.; Kerr, P. J.; Simms, N. G.; Robinson, A. J.

2003-01-01

A survey of rabbit populations in the southern tablelands of New South Wales, Australia, was carried out to establish the pattern of occurrence of myxomatosis in preparation for a deliberate release of myxoma virus. Myxomatosis was first detected in December and cases were found on most sites through to May. The serological profiles of rabbit populations suggested that their susceptibility to myxoma virus was generally low in winter and highest in spring and summer reflecting the presence of increasing numbers of susceptible young rabbits. This was consistent with the pattern of rabbit breeding, as determined from the distribution of births and reproductive activity in females and males, which occurred maximally in spring and early summer. The serology and age structure of rabbit populations on sites suggested that some rabbit populations can escape an annual myxomatosis epizootic. Although fleas were present on rabbits throughout the year and therefore not considered to be a limiting factor in the spread of myxomatosis, their numbers peaked at times coincident with peak rabbit breeding. It was concluded that mid to late spring was an optimal time for a deliberate release. PMID:12613753

Monitoring the spread of myxoma virus in rabbit Oryctolagus cuniculus populations on the southern tablelands of New South Wales, Australia. I. Natural occurrence of myxomatosis.

PubMed

Merchant, J C; Kerr, P J; Simms, N G; Robinson, A J

2003-02-01

A survey of rabbit populations in the southern tablelands of New South Wales, Australia, was carried out to establish the pattern of occurrence of myxomatosis in preparation for a deliberate release of myxoma virus. Myxomatosis was first detected in December and cases were found on most sites through to May. The serological profiles of rabbit populations suggested that their susceptibility to myxoma virus was generally low in winter and highest in spring and summer reflecting the presence of increasing numbers of susceptible young rabbits. This was consistent with the pattern of rabbit breeding, as determined from the distribution of births and reproductive activity in females and males, which occurred maximally in spring and early summer. The serology and age structure of rabbit populations on sites suggested that some rabbit populations can escape an annual myxomatosis epizootic. Although fleas were present on rabbits throughout the year and therefore not considered to be a limiting factor in the spread of myxomatosis, their numbers peaked at times coincident with peak rabbit breeding. It was concluded that mid to late spring was an optimal time for a deliberate release.

Fabrication and characteristics of excellent current spreading GaN-based LED by using transparent electrode-insulator-semiconductor structure

NASA Astrophysics Data System (ADS)

Qi, Chenglin; Huang, Yang; Zhan, Teng; Wang, Qinjin; Yi, Xiaoyan; Liu, Zhiqiang

2017-08-01

GaN-based vertical light-emitting-diodes (V-LEDs) with an improved current injection pattern were fabricated and a novel current injection pattern of LEDs which consists of electrode-insulator-semiconductor (EIS) structure was proposed. The EIS structure was achieved by an insulator layer (20-nm Ta2O5) deposited between the p-GaN and the ITO layer. This kind of EIS structure works through a defect-assisted tunneling mechanism to realize current injection and obtains a uniform current distribution on the chip surface, thus greatly improving the current spreading ability of LEDs. The appearance of this novel current injection pattern of V-LEDs will subvert the impression of the conventional LEDs structure, including simplifying the chip manufacture technology and reducing the chip cost. Under a current density of 2, 5, 10, and 25 A/cm2, the luminous uniformity was better than conventional structure LEDs. The standard deviation of power density distribution in light distribution was 0.028, which was much smaller than that of conventional structure LEDs and illustrated a huge advantage on the current spreading ability of EIS-LEDs. Project supported by the Natural Science Foundation of China (Nos. 61306051, 61306050) and the National High Technology Program of China (No. 2014AA032606).

Potential fields on the ventricular surface of the exposed dog heart during normal excitation.

PubMed

Arisi, G; Macchi, E; Baruffi, S; Spaggiari, S; Taccardi, B

1983-06-01

We studied the normal spread of excitation on the anterior and posterior ventricular surface of open-chest dogs by recording unipolar electrograms from an array of 1124 electrodes spaced 2 mm apart. The array had the shape of the ventricular surface of the heart. The electrograms were processed by a computer and displayed as epicardial equipotential maps at 1-msec intervals. Isochrone maps also were drawn. Several new features of epicardial potential fields were identified: (1) a high number of breakthrough points; (2) the topography, apparent widths, velocities of the wavefronts and the related potential drop; (3) the topography of positive potential peaks in relation to the wavefronts. Fifteen to 24 breakthrough points were located on the anterior, and 10 to 13 on the posterior ventricular surface. Some were in previously described locations and many others in new locations. Specifically, 3 to 5 breakthrough points appeared close to the atrioventricular groove on the anterior right ventricle and 2 to 4 on the posterior heart aspect; these basal breakthrough points appeared when a large portion of ventricular surface was still unexcited. Due to the presence of numerous breakthrough points on the anterior and posterior aspect of the heart which had not previously been described, the spread of excitation on the ventricular surface was "mosaic-like," with activation wavefronts spreading in all directions, rather than radially from the two breakthrough points, as traditionally described. The positive potential peaks which lay ahead of the expanding wavefronts moved along preferential directions which were probably related to the myocardial fiber direction.

The Interaction of Risk Network Structures and Virus Natural History in the Non-spreading of HIV Among People Who Inject Drugs in the Early Stages of the Epidemic.

PubMed

Dombrowski, Kirk; Khan, Bilal; Habecker, Patrick; Hagan, Holly; Friedman, Samuel R; Saad, Mohamed

2017-04-01

This article explores how social network dynamics may have reduced the spread of HIV-1 infection among people who inject drugs during the early years of the epidemic. Stochastic, discrete event, agent-based simulations are used to test whether a "firewall effect" can arise out of self-organizing processes at the actor level, and whether such an effect can account for stable HIV prevalence rates below population saturation. Repeated simulation experiments show that, in the presence of recurring, acute, and highly infectious outbreaks, micro-network structures combine with the HIV virus's natural history to reduce the spread of the disease. These results indicate that network factors likely played a significant role in the prevention of HIV infection within injection risk networks during periods of peak prevalence. They also suggest that social forces that disturb network connections may diminish the natural firewall effect and result in higher rates of HIV.

The Interaction of Risk Network Structures and Virus Natural History in the non-Spreading of HIV among People Who Inject Drugs in the Early Stages of the Epidemic

PubMed Central

Dombrowski, Kirk; Khan, Bilal; Habecker, Patrick; Hagan, Holly; Friedman, Samuel R.; Saad, Mohamed

2016-01-01

This article explores how social network dynamics may have reduced the spread of HIV-1 infection among people who inject drugs during the early years of the epidemic. Stochastic, discrete event, agent-based simulations are used to test whether a “firewall effect” can arise out of self-organizing processes at the actor level, and whether such an effect can account for stable HIV prevalence rates below population saturation. Repeated simulation experiments show that, in the presence of recurring, acute, and highly infectious outbreaks, micro-network structures combine with the HIV virus’s natural history to reduce the spread of the disease. These results indicate that network factors likely played a significant role in the prevention of HIV infection within injection risk networks during periods of peak prevalence. They also suggest that social forces that disturb network connections may diminish the natural firewall effect and result in higher rates of HIV. PMID:27699596

EGFR and HER2 activate rigidity sensing only on rigid matrices

NASA Astrophysics Data System (ADS)

Saxena, Mayur; Liu, Shuaimin; Yang, Bo; Hajal, Cynthia; Changede, Rishita; Hu, Junqiang; Wolfenson, Haguy; Hone, James; Sheetz, Michael P.

2017-07-01

Epidermal growth factor receptor (EGFR) interacts with integrins during cell spreading and motility, but little is known about the role of EGFR in these mechanosensing processes. Here we show, using two different cell lines, that in serum- and EGF-free conditions, EGFR or HER2 activity increase spreading and rigidity-sensing contractions on rigid, but not soft, substrates. Contractions peak after 15-20 min, but diminish by tenfold after 4 h. Addition of EGF at that point increases spreading and contractions, but this can be blocked by myosin-II inhibition. We further show that EGFR and HER2 are activated through phosphorylation by Src family kinases (SFK). On soft surfaces, neither EGFR inhibition nor EGF stimulation have any effect on cell motility. Thus, EGFR or HER2 can catalyse rigidity sensing after associating with nascent adhesions under rigidity-dependent tension downstream of SFK activity. This has broad implications for the roles of EGFR and HER2 in the absence of EGF both for normal and cancerous growth.

Horizontal study of vaccinia virus infections in an endemic area: epidemiologic, phylogenetic and economic aspects.

PubMed

Assis, Felipe L; Franco-Luiz, Ana Paula M; Paim, Luis M; Oliveira, Graziele P; Pereira, Alexandre F; de Almeida, Gabriel M F; Figueiredo, Leandra B; Tanus, Adriano; Trindade, Giliane S; Ferreira, Paulo P; Kroon, Erna G; Abrahão, Jônatas S

2015-11-01

Vaccinia virus (VACV), the etiological agent of bovine vaccinia (BV), is widespread in Brazil and present in most of the milk-producing regions. We conducted a horizontal study of BV in Bahia, a state of Brazil in which the production of milk is increasing. During 2011, human and bovine clinical samples were collected during outbreaks for BV diagnosis, virus isolation and molecular analysis. We collected data for epidemiological inferences. Vaccinia virus was detected in 87.7% of the analyzed outbreaks, highlighting the effective circulation of VACV in Bahia. The molecular data showed the spreading of group 1 Brazilian VACV to Bahia. We observed a seasonal profile of BV, with its peak in the drier and cooler season. Manual milking was observed in 96 % of the visited properties, showing its importance to viral spread in herds. Under-notification of BV, ineffective animal trade surveillance, and bad milking practices have contributed to the spread of VACV in Brazil.

EGFR and HER2 Activate Rigidity Sensing Only on Rigid Matrices

PubMed Central

Saxena, Mayur; Liu, Shuaimin; Yang, Bo; Hajal, Cynthia; Changede, Rishita; Hu, Junqiang

2017-01-01

Epidermal growth factor receptor (EGFR) interacts with integrins during cell spreading and motility, but little is known about the role of EGFR in these mechanosensing processes. Here we show, using two different cell lines, that in serum- and EGF-free conditions, EGFR or HER2 activity increase spreading and rigidity-sensing contractions on rigid, but not soft, substrates. Contractions peak after 15–20 min, but diminish by 10-fold after 4 hours. Addition of EGF at that point increases spreading and contractions, but this can be blocked by myosin-II inhibition. We further show that EGFR and HER2 are activated through phosphorylation by Src family kinases (SFK). On soft surfaces, neither EGFR inhibition nor EGF stimulation have any effect on cell motility. Thus, EGFR or HER2 can catalyse rigidity sensing after associating with nascent adhesions under rigidity-dependent tension downstream of SFK activity. This has broad implications for the roles of EGFR and HER2 in absence of EGF both for normal and cancerous growth. PMID:28459445

Satellite remote sensing of the island mass effect on the Sub-Antarctic Kerguelen Plateau, Southern Ocean

NASA Astrophysics Data System (ADS)

Jena, Babula

2016-09-01

The presence of the Kerguelen Plateau and surrounding bathymetric features has a strong influence on the persistently eastward flowing Antarctic Circumpolar Current (ACC), resulting in enhancement of surface chlorophyll-a (Chl- a) in the downstream section of the plateau along the polar front (PF). The phenomenon is reported in this paper as the island mass effect (IME). Analysis of climatological Chl- a datasets from Aqua- Moderate Resolution Imaging Spectroradiometer (Aqua- MODIS) and Sea-viewing Wide Field-of-view Sensor (SeaWiFS) shows distinct bloomy plumes (Chl- a>0.5 mg/m3) during austral spring-summer spreading as far as ~1800 km offshore up to 98°E along the downstream of the north Kerguelen Plateau (NKP). Similar IME phenomena is apparent over the south Kerguelen Plateau (SKP) with the phytoplankton bloom extending up to 96.7°E, along the southern boundary of ACC. The IME phenomena are pronounced only during austral spring-summer period with the availability of light and sedimentary source of iron from shallow plateau to sea surface that fertilizes the mixed layer. The NKP bloom peaks with a maximum areal extent of 1.315 million km2 during December, and the SKP bloom peaks during January with a time lag of one month. The blooms exist for at least 4 months of a year and are significant both as the base of regional food web and for regulating the biogeochemical cycle in the Southern Ocean. Even though the surface water above the Kerguelen Plateau is rich in Chl- a, an exception of an oligotrophic condition dominated between NKP and SKP due to apparent intrusion of iron limited low phytoplankton regime waters from the Enderby basin through the northeastward Fawn Trough Current.

Properties of micro-arc oxidation coatings on aluminum alloy at different negative peak current densities

NASA Astrophysics Data System (ADS)

Gu, Xin; Jiang, Bailing; Li, Hongtao; Liu, Cancan; Shao, Lianlian

2018-05-01

Micro-arc oxidation coatings were fabricated on 6061 aluminum alloy using whereby bipolar pulse mode in the case of different negative peak current densities. The phase composition, microstructures and wear properties were studied using x-ray diffraction, scanning electron microscopy and ball-on-disk wear tester, respectively. As results indicate, by virtue of negative peak current density, the oxygen can be expelled by produced hydrogen on anode in the case of negative pulse width and via the opened discharge channel. The results of x-ray diffraction, surface and cross-sectional morphology indicated that the coating was structured compactly taking on less small-diameter micro-pores and defects with negative peak current density of 75 A dm‑2. Additionally, as the results of wear tracks and weight loss bespeak, by virtue of appropriate negative peak current density, coatings resisted the abrasive wear and showed excellent wear resistance.

Dosimetric properties of a proton beamline dedicated to the treatment of ocular disease

DOE Office of Scientific and Technical Information (OSTI.GOV)

Slopsema, R. L., E-mail: rslopsema@floridaproton.org; Mamalui, M.; Yeung, D.

2014-01-15

Purpose: A commercial proton eyeline has been developed to treat ocular disease. Radiotherapy of intraocular lesions (e.g., uveal melanoma, age-related macular degeneration) requires sharp dose gradients to avoid critical structures like the macula and optic disc. A high dose rate is needed to limit patient gazing times during delivery of large fractional dose. Dose delivery needs to be accurate and predictable, not in the least because current treatment planning algorithms have limited dose modeling capabilities. The purpose of this paper is to determine the dosimetric properties of a new proton eyeline. These properties are compared to those of existing systemsmore » and evaluated in the context of the specific clinical requirements of ocular treatments. Methods: The eyeline is part of a high-energy, cyclotron-based proton therapy system. The energy at the entrance of the eyeline is 105 MeV. A range modulator (RM) wheel generates the spread-out Bragg peak, while a variable range shifter system adjusts the range and spreads the beam laterally. The range can be adjusted from 0.5 up to 3.4 g/cm{sup 2}; the modulation width can be varied in steps of 0.3 g/cm{sup 2} or less. Maximum field diameter is 2.5 cm. All fields can be delivered with a dose rate of 30 Gy/min or more. The eyeline is calibrated according to the IAEA TRS-398 protocol using a cylindrical ionization chamber. Depth dose distributions and dose/MU are measured with a parallel-plate ionization chamber; lateral profiles with radiochromic film. The dose/MU is modeled as a function of range, modulation width, and instantaneous MU rate with fit parameters determined per option (RM wheel). Results: The distal fall-off of the spread-out Bragg peak is 0.3 g/cm{sup 2}, larger than for most existing systems. The lateral penumbra varies between 0.9 and 1.4 mm, except for fully modulated fields that have a larger penumbra at skin. The source-to-axis distance is found to be 169 cm. The dose/MU shows a strong dependence on range (up to 4%/mm). A linear increase in dose/MU as a function of instantaneous MU rate is observed. The dose/MU model describes the measurements with an accuracy of ±2%. Neutron dose is found to be 146 ± 102 μSv/Gy at the contralateral eye and 19 ± 13 μSv/Gy at the chest. Conclusions: Measurements show the proton eyeline meets the requirements to effectively treat ocular disease.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Slopsema, R. L., E-mail: rslopsema@floridaproton.org; Mamalui, M.; Yeung, D.

Purpose: A commercial proton eyeline has been developed to treat ocular disease. Radiotherapy of intraocular lesions (e.g., uveal melanoma, age-related macular degeneration) requires sharp dose gradients to avoid critical structures like the macula and optic disc. A high dose rate is needed to limit patient gazing times during delivery of large fractional dose. Dose delivery needs to be accurate and predictable, not in the least because current treatment planning algorithms have limited dose modeling capabilities. The purpose of this paper is to determine the dosimetric properties of a new proton eyeline. These properties are compared to those of existing systemsmore » and evaluated in the context of the specific clinical requirements of ocular treatments. Methods: The eyeline is part of a high-energy, cyclotron-based proton therapy system. The energy at the entrance of the eyeline is 105 MeV. A range modulator (RM) wheel generates the spread-out Bragg peak, while a variable range shifter system adjusts the range and spreads the beam laterally. The range can be adjusted from 0.5 up to 3.4 g/cm{sup 2}; the modulation width can be varied in steps of 0.3 g/cm{sup 2} or less. Maximum field diameter is 2.5 cm. All fields can be delivered with a dose rate of 30 Gy/min or more. The eyeline is calibrated according to the IAEA TRS-398 protocol using a cylindrical ionization chamber. Depth dose distributions and dose/MU are measured with a parallel-plate ionization chamber; lateral profiles with radiochromic film. The dose/MU is modeled as a function of range, modulation width, and instantaneous MU rate with fit parameters determined per option (RM wheel). Results: The distal fall-off of the spread-out Bragg peak is 0.3 g/cm{sup 2}, larger than for most existing systems. The lateral penumbra varies between 0.9 and 1.4 mm, except for fully modulated fields that have a larger penumbra at skin. The source-to-axis distance is found to be 169 cm. The dose/MU shows a strong dependence on range (up to 4%/mm). A linear increase in dose/MU as a function of instantaneous MU rate is observed. The dose/MU model describes the measurements with an accuracy of ±2%. Neutron dose is found to be 146 ± 102 μSv/Gy at the contralateral eye and 19 ± 13 μSv/Gy at the chest. Conclusions: Measurements show the proton eyeline meets the requirements to effectively treat ocular disease.« less

Coordinated train control and energy management control strategies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gordon, S.P.; Lehrer, D.G.

1998-05-01

The Bay Area Rapid Transit (BART) system, in collaboration with Hughes Aircraft Company and Harmon Industries, as in the process of developing an Advanced Automatic Train Control (AATC) system to replace the current fixed-block automatic system. In the long run, the AATC system is expected to not only allow for safe short headway operation, but also to facilitate coordinated train control and energy management. This new system will employ spread spectrum radios, installed onboard trains, at wayside locations, and at control stations, to determine train locations and reliably transfer control information. Sandia National Laboratories has worked cooperatively with BART tomore » develop a simulator of the train control and the power consumption of the AATC system. The authors are now in the process of developing enhanced train control algorithms to supplement the safety critical controller in order to smooth out train trajectories through coordinated control of multiple trains, and to reduce energy consumption and power infrastructure requirements. The control algorithms so far considered include (1) reducing peak power consumption to avoid voltage sags, especially during an outage or while clearing a backup, (2) rapid and smooth recovery from a backup, (3) avoiding oscillations due to train interference, (4) limiting needle peaks in power demand at substations to some specified level, (5) coasting, and (6) coordinating train movement, e.g., starts/stops and hills.« less

Method and apparatus for clockless analog-to-digital conversion and peak detection

DOEpatents

DeGeronimo, Gianluigi

2007-03-06

An apparatus and method for analog-to-digital conversion and peak detection includes at least one stage, which includes a first switch, second switch, current source or capacitor, and discriminator. The discriminator changes state in response to a current or charge associated with the input signal exceeding a threshold, thereby indicating whether the current or charge associated with the input signal is greater than the threshold. The input signal includes a peak or a charge, and the converter includes a peak or charge detect mode in which a state of the switch is retained in response to a decrease in the current or charge associated with the input signal. The state of the switch represents at least a portion of a value of the peak or of the charge.

Hydrothermal venting along Earth's fastest spreading center: East Pacific Rise, 27.5°-32.3°

NASA Astrophysics Data System (ADS)

Baker, E. T.; Hey, R. N.; Lupton, J. E.; Resing, J. A.; Feely, R. A.; Gharib, J. J.; Massoth, G. J.; Sansone, F. J.; Kleinrock, M.; Martinez, F.; Naar, D. F.; Rodrigo, C.; Bohnenstiehl, D.; Pardee, D.

2002-07-01

During March/April 1998 we conducted detailed mapping and sampling of hydrothermal plumes along six segments of Earth's fasting spreading mid-ocean ridge, 27.5°-32.3°S on the East Pacific Rise. We compared the distribution and chemistry of hydrothermal plumes to geological indicators of long-term (spreading rate) and moderate-term (ridge inflation) variations in magmatic budget. In this large-offset, propagating rift setting, these geological indices span virtually the entire range found along fast spreading ridges worldwide. Hydrothermal plumes overlaid ~60% of the length of superfast (>130 km/Myr) spreading axis surveyed and defined at least 14 separate vent fields. We observed no plumes over the slower spreading propagating segments. Finer-scale variations in the magmatic budget also correlated with hydrothermal activity, as the location of the five most intense plumes corresponded to subsegment peaks in ridge inflation. Along the entire ridge crest, the more inflated a ridge location the more likely it was to be overlain by a hydrothermal plume. Plume chemistry mostly reflected discharge from mature vent fields apparently unperturbed by magmatic activity within the last few years. Plume samples with high volatile/metal ratios, generally indicating recent seafloor volcanism, were scarce. Along-axis trends in both volatile (3He; CH4; ΔpH, a proxy for CO2; and particulate S) and nonvolatile (Fe, Mn) species showed a first-order agreement with the trend of ridge inflation. Nevertheless, a broad correspondence between the concentration of volatile species in plumes and geological proxies of magma supply identifies a pervasive magmatic imprint on this superfast spreading group of ridge segments.

Antiproton radiotherapy.

PubMed

Bassler, Niels; Alsner, Jan; Beyer, Gerd; DeMarco, John J; Doser, Michael; Hajdukovic, Dragan; Hartley, Oliver; Iwamoto, Keisuke S; Jäkel, Oliver; Knudsen, Helge V; Kovacevic, Sandra; Møller, Søren Pape; Overgaard, Jens; Petersen, Jørgen B; Solberg, Timothy D; Sørensen, Brita S; Vranjes, Sanja; Wouters, Bradly G; Holzscheiter, Michael H

2008-01-01

Antiprotons are interesting as a possible future modality in radiation therapy for the following reasons: When fast antiprotons penetrate matter, protons and antiprotons have near identical stopping powers and exhibit equal radiobiology well before the Bragg-peak. But when the antiprotons come to rest at the Bragg-peak, they annihilate, releasing almost 2 GeV per antiproton-proton annihilation. Most of this energy is carried away by energetic pions, but the Bragg-peak of the antiprotons is still locally augmented with approximately 20-30 MeV per antiproton. Apart from the gain in physical dose, an increased relative biological effect also has been observed, which can be explained by the fact that some of the secondary particles from the antiproton annihilation exhibit high-LET properties. Finally, the weakly interacting energetic pions, which are leaving the target volume, may provide a real time feedback on the exact location of the annihilation peak. We have performed dosimetry experiments and investigated the radiobiological properties using the antiproton beam available at CERN, Geneva. Dosimetry experiments were carried out with ionization chambers, alanine pellets and radiochromic film. Radiobiological experiments were done with V79 WNRE Chinese hamster cells. The radiobiological experiments were repeated with protons and carbon ions at TRIUMF and GSI, respectively, for comparison. Several Monte Carlo particle transport codes were investigated and compared with our experimental data obtained at CERN. The code that matched our data best was used to generate a set of depth dose data at several energies, including secondary particle-energy spectra. This can be used as base data for a treatment planning software such as TRiP. Our findings from the CERN experiments indicate that the biological effect of antiprotons in the plateau region may be reduced by a factor of 4 for the same biological target dose in a spread-out Bragg-peak, when comparing with protons. The extension of TRiP to handle antiproton beams is currently in progress. This will enable us to perform planning studies, where the potential clinical consequences can be examined, and compared to those of other beam modalities such as protons, carbon ions, or IMRT photons.

Status Report on the CEBAF IR and UV FELs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leemann, Christoph; Bisognano, Joseph; Douglas, David

1993-07-01

The CEBAF five pass recirculating, superconducting linac, being developed as a high power electron source for nuclear physics, is also an ideal FEL driver.The 45 MeV front end linac is presently operational with a CW (low peak current) nuclear physics gun and has met all CEBAF performance specifications including low emittance and energy spread (< 1 * 10^-4). Progress will be reported in commissioning.This experience leads to predictions of excellent FEL performance.Initial designs reported last year have been advanced.Using the output of a high charge DC photoemission gun under development with a 6 cm period wiggler produces kilowatt output powersmore » in the 3.6 to 17 micrometer range in the fundamental.Third harmonic operation extends IR performance down to 1.2 micrometer.Beam at energies up to 400 MeV from the first full CEBAF linac will interact in a similar but longer wiggler to yield kilowatt UV light production at wavelengths as short as 0.15 micrometers.Full power FEL« less

Undulator-Based Laser Wakefield Accelerator Electron Beam Energy Spread and Emittance Diagnostic

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bakeman, M. S.; University of Nevada Reno, Reno, NV 89557; Van Tilborg, J.

The design and current status of experiments to couple the Tapered Hybrid Undulator (THUNDER) to the Lawrence Berkeley National Laboratory (LBNL) laser plasma accelerator (LPA) to measure electron beam energy spread and emittance are presented.

Catalog of earthquake hypocenters for Augustine, Redoubt, Iliamna, and Mount Spurr volcanoes, Alaska: January 1, 1991 - December 31, 1993

USGS Publications Warehouse

Jolly, Arthur D.; Power, John A.; Stihler, Scott D.; Rao, Lalitha N.; Davidson, Gail; Paskievitch, John F.; Estes, Steve; Lahr, John C.

1996-01-01

The 1992 eruptions at Mount Spurr's Crater Peak vent provided the highlight of the catalog period. The crisis included three sub-plinian eruptions, which occurred on June 27, August 18, and September 16-17, 1992. The three eruptions punctuated a complex seismic sequence which included volcano-tectonic (VT) earthquakes, tremor, and both deep and shallow long period (LP) earthquakes. The seismic sequence began on August 18, 1991, with a small swarm of volcano-tectonic events beneath Crater Peak, and spread throughout the volcanic complex by November of the same year. Elevated levels of seismicity persisted at Mount Spurr beyond the catalog time period.

Plantar pressure and daily cumulative stress in persons affected by leprosy with current, previous and no previous foot ulceration.

PubMed

van Schie, Carine H M; Slim, Frederik J; Keukenkamp, Renske; Faber, William R; Nollet, Frans

2013-03-01

Not only plantar pressure but also weight-bearing activity affects accumulated mechanical stress to the foot and may be related to foot ulceration. To date, activity has not been accounted for in leprosy. The purpose was to compare barefoot pressure, in-shoe pressure and daily cumulative stress between persons affected by leprosy with and without previous or current foot ulceration. Nine persons with current plantar ulceration were compared to 15 with previous and 15 without previous ulceration. Barefoot peak pressure (EMED-X), in-shoe peak pressure (Pedar-X) and daily cumulative stress (in-shoe forefoot pressure time integral×mean daily strides (Stepwatch™ Activity Monitor)) were measured. Barefoot peak pressure was increased in persons with current and previous compared to no previous foot ulceration (mean±SD=888±222 and 763±335 vs 465±262kPa, p<0.05). In-shoe peak pressure was only increased in persons with current compared to without previous ulceration (mean±SD=412±145 vs 269±70kPa, p<0.05). Daily cumulative stress was not different between groups, although persons with current and previous foot ulceration were less active. Although barefoot peak pressure was increased in people with current and previous plantar ulceration, it did not discriminate between these groups. While in-shoe peak pressure was increased in persons with current ulceration, they were less active, resulting in no difference in daily cumulative stress. Increased in-shoe peak pressure suggests insufficient pressure reducing footwear in persons with current ulceration, highlighting the importance of pressure reducing qualities of footwear. Copyright © 2012 Elsevier B.V. All rights reserved.

40 CFR 761.347 - First level sampling-waste from existing piles.

Code of Federal Regulations, 2012 CFR

2012-07-01

... separate 19-liter container, allowing only sufficient space at the top of the container to secure the lid... of 1 foot or 30 cm, or if there are too many piles to spread out in the space available, use the... parameters: a particular radial direction, “r,” from the peak at the center of the pile to the outer edge at...

Microdosimetric investigation at the therapeutic proton beam facility of CATANA.

PubMed

De Nardo, L; Moro, D; Colautti, P; Conte, V; Tornielli, G; Cuttone, G

2004-01-01

Proton beams (62 Mev) are used by the Laboratori Nazionali del Sud of the Italian Institute of Nuclear Physics to treat eye melanoma tumours at the therapeutic facility called CATANA. A cylindrical slim tissue-equivalent proportional counter (TEPC) of 2.7 mm external diameter has been used to compare the radiation quality of two spread-out Bragg peaks (SOBP) at the CATANA proton beam.

Solution-Processed Germanium Nanowire-Positioned Schottky Solar Cells

DTIC Science & Technology

2011-04-01

nanowire (GeNW)-positioned Schottky solar cell was fabricated by a solution process. A GeNW-containing solution was spread out onto asymmetric metal ...177 mV and a short-circuit current of 19.2 nA. Schottky and ohmic contacts between a single GeNW and different metal electrodes were systematically...containing solution was spread out onto asymmetric metal electrodes to produce a rectifying current flow. Under one-sun illumination, the GeNW

Comparison of tissue distribution, phrenic nerve involvement, and epidural spread in standard- vs low-volume ultrasound-guided interscalene plexus block using contrast magnetic resonance imaging: a randomized, controlled trial.

PubMed

Stundner, O; Meissnitzer, M; Brummett, C M; Moser, S; Forstner, R; Koköfer, A; Danninger, T; Gerner, P; Kirchmair, L; Fritsch, G

2016-03-01

Ultrasound guidance allows for the use of much lower volumes of local anaesthetics for nerve blocks, which may be associated with less aberrant spread and fewer complications. This randomized, controlled study used contrast magnetic resonance imaging to view the differential-volume local anaesthetic distribution, and compared analgesic efficacy and respiratory impairment. Thirty patients undergoing shoulder surgery were randomized to receive ultrasound-guided interscalene block by a single, blinded operator with injection of ropivacaine 0.75% (either 20 or 5 ml) plus the contrast dye gadopentetate dimeglumine, followed by magnetic resonance imaging. The primary outcome was epidural spread. Secondary outcomes were central non-epidural spread, contralateral epidural spread, spread to the phrenic nerve, spirometry, ultrasound investigation of the diaphragm, block duration, pain scores during the first 24 h, time to first analgesic consumption, and total analgesic consumption. All blocks provided fast onset and adequate intra- and postoperative analgesia, with no significant differences in pain scores at any time point. Epidural spread occurred in two subjects of each group (13.3%); however, spread to the intervertebral foramen and phrenic nerve and extensive i.m. local anaesthetic deposition were significantly more frequent in the 20 ml group. Diaphragmatic paralysis occurred twice as frequently (n=8 vs 4), and changes from baseline peak respiratory flow rate were larger [Δ=-2.66 (1.99 sd) vs -1.69 (2.0 sd) l min(-1)] in the 20 ml group. This study demonstrates that interscalene block is associated with epidural spread irrespective of injection volume; however, less central (foraminal) and aberrant spread after low-volume injection may be associated with a more favourable risk profile. This study was registered with the European Medicines Agency (Eudra-CT number 2013-004219-36) and with the US National Institutes' of Health registry and results base, clinicaltrials.gov (identifier NCT02175069). © The Author 2016. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Low Reynolds number suspension gravity currents.

PubMed

Saha, Sandeep; Salin, Dominique; Talon, Laurent

2013-08-01

The extension of a gravity current in a lock-exchange problem, proceeds as square root of time in the viscous-buoyancy phase, where there is a balance between gravitational and viscous forces. In the presence of particles however, this scenario is drastically altered, because sedimentation reduces the motive gravitational force and introduces a finite distance and time at which the gravity current halts. We investigate the spreading of low Reynolds number suspension gravity currents using a novel approach based on the Lattice-Boltzmann (LB) method. The suspension is modeled as a continuous medium with a concentration-dependent viscosity. The settling of particles is simulated using a drift flux function approach that enables us to capture sudden discontinuities in particle concentration that travel as kinematic shock waves. Thereafter a numerical investigation of lock-exchange flows between pure fluids of unequal viscosity, reveals the existence of wall layers which reduce the spreading rate substantially compared to the lubrication theory prediction. In suspension gravity currents, we observe that the settling of particles leads to the formation of two additional fronts: a horizontal front near the top that descends vertically and a sediment layer at the bottom which aggrandises due to deposition of particles. Three phases are identified in the spreading process: the final corresponding to the mutual approach of the two horizontal fronts while the laterally advancing front halts indicating that the suspension current stops even before all the particles have settled. The first two regimes represent a constant and a decreasing spreading rate respectively. Finally we conduct experiments to substantiate the conclusions of our numerical and theoretical investigation.

Optical absorption and thermally stimulated depolarization current studies of nickel chloride-doped poly(vinyl alcohol) irradiated with low-level fast neutron doses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abd El-Kader, F.H.; Ibrahim, S.S.; Attia, G.

1993-11-15

The influence of neutron irradiation on ultraviolet/visible absorption and thermally stimulated depolarization current in nickel chloride-poly(vinyl alcohol) (PVA) cast films has been investigated. The spectral measurements indicate the responsibility of the Ni[sup 2][sup +] ion in its octahedral symmetry. Dopant concentrations higher than 10 wt % NiCl[sub 2] are found to make the samples more resistant to a degradation effect caused by neutron irradiation. The thermally stimulated depolarization currents (TSDC) of pure PVA revealed the existence of the glass transition T[sub g] and space charge relaxation peaks, whereas doped-PVA samples show a new sub-T[sub g] relaxation peak. A proposed mechanismmore » is introduced to account for the neutron effects on both glass transition and space charge relaxation peaks. The peak positions, peak currents, and stored charges of the sub-T[sub g] relaxation peak are strongly affected by both the concentration of the dopant and neutron exposure doses.« less

Contribution For Arc Temperature Affected By Current Increment Ratio At Peak Current In Pulsed Arc

NASA Astrophysics Data System (ADS)

Kano, Ryota; Mitubori, Hironori; Iwao, Toru

2015-11-01

Tungsten Inert Gas (TIG) Welding is one of the high quality welding. However, parameters of the pulsed arc welding are many and complicated. if the welding parameters are not appropriate, the welding pool shape becomes wide and shallow.the convection of driving force contributes to the welding pool shape. However, in the case of changing current waveform as the pulse high frequency TIG welding, the arc temperature does not follow the change of the current. Other result of the calculation, in particular, the arc temperature at the reaching time of peak current is based on these considerations. Thus, the accurate measurement of the temperature at the time is required. Therefore, the objective of this research is the elucidation of contribution for arc temperature affected by current increment ratio at peak current in pulsed arc. It should obtain a detail knowledge of the welding model in pulsed arc. The temperature in the case of increment of the peak current from the base current is measured by using spectroscopy. As a result, when the arc current increases from 100 A to 150 A at 120 ms, the transient response of the temperature didn't occur during increasing current. Thus, during the current rise, it has been verified by measuring. Therefore, the contribution for arc temperature affected by current increment ratio at peak current in pulsed arc was elucidated in order to obtain more knowledge of welding model of pulsed arc.

Pulse charging of lead-acid traction cells

NASA Technical Reports Server (NTRS)

Smithrick, J. J.

1980-01-01

Pulse charging, as a method of rapidly and efficiently charging 300 amp-hour lead-acid traction cells for an electric vehicle application was investigated. A wide range of charge pulse current square waveforms were investigated and the results were compared to constant current charging at the time averaged pulse current values. Representative pulse current waveforms were: (1) positive waveform-peak charge pulse current of 300 amperes (amps), discharge pulse-current of zero amps, and a duty cycle of about 50%; (2) Romanov waveform-peak charge pulse current of 300 amps, peak discharge pulse current of 15 amps, and a duty of 50%; and (3) McCulloch waveform peak charge pulse current of 193 amps, peak discharge pulse current of about 575 amps, and a duty cycle of 94%. Experimental results indicate that on the basis of amp-hour efficiency, pulse charging offered no significant advantage as a method of rapidly charging 300 amp-hour lead-acid traction cells when compared to constant current charging at the time average pulse current value. There were, however, some disadvantages of pulse charging in particular a decrease in charge amp-hour and energy efficiencies and an increase in cell electrolyte temperature. The constant current charge method resulted in the best energy efficiency with no significant sacrifice of charge time or amp-hour output. Whether or not pulse charging offers an advantage over constant current charging with regard to the cell charge/discharge cycle life is unknown at this time.

Metamorphism and aqueous alteration in low petrographic type ordinary chondrites

NASA Technical Reports Server (NTRS)

Xie, T.; Lipschutz, M. E.; Sears, D. W. G.; Guimon, R. K.; Jie, Lu; Benoit, P. H.; O'D. Alexander, C. M.; Wright, Ian; Pillinger, C.; Morse, A. D.;

Current status of genome editing in vector mosquitoes: A review.

PubMed

Reegan, Appadurai Daniel; Ceasar, Stanislaus Antony; Paulraj, Michael Gabriel; Ignacimuthu, Savarimuthu; Al-Dhabi, Naif Abdullah

2017-01-16

Mosquitoes pose a major threat to human health as they spread many deadly diseases like malaria, dengue, chikungunya, filariasis, Japanese encephalitis and Zika. Identification and use of novel molecular tools are essential to combat the spread of vector borne diseases. Genome editing tools have been used for the precise alterations of the gene of interest for producing the desirable trait in mosquitoes. Deletion of functional genes or insertion of toxic genes in vector mosquitoes will produce either knock-out or knock-in mutants that will check the spread of vector-borne diseases. Presently, three types of genome editing tools viz., zinc finger nuclease (ZFN), transcription activator-like effector nucleases (TALEN) and clustered regulatory interspaced short palindromic repeats (CRISPR) and CRISPR associated protein 9 (Cas9) are widely used for the editing of the genomes of diverse organisms. These tools are also applied in vector mosquitoes to control the spread of vector-borne diseases. A few studies have been carried out on genome editing to control the diseases spread by vector mosquitoes and more studies need to be performed with the utilization of more recently invented tools like CRISPR/Cas9 to combat the spread of deadly diseases by vector mosquitoes. The high specificity and flexibility of CRISPR/Cas9 system may offer possibilities for novel genome editing for the control of important diseases spread by vector mosquitoes. In this review, we present the current status of genome editing research on vector mosquitoes and also discuss the future applications of vector mosquito genome editing to control the spread of vectorborne diseases.

Reconstructing the magnetosphere from data using radial basis functions

NASA Astrophysics Data System (ADS)

Andreeva, Varvara A.; Tsyganenko, Nikolai A.

2016-03-01

A new method is proposed to derive from data magnetospheric magnetic field configurations without any a priori assumptions on the geometry of electric currents. The approach utilizes large sets of archived satellite data and uses an advanced technique to represent the field as a sum of toroidal and poloidal parts, whose generating potentials Ψ1 and Ψ2 are expanded into series of radial basis functions (RBFs) with their nodes regularly distributed over the 3-D modeling domain. The method was tested by reconstructing the inner and high-latitude field within geocentric distances up to 12RE on the basis of magnetometer data of Geotail, Polar, Cluster, Time History of Events and Macroscale Interactions during Substorms, and Van Allen space probes, taken during 1995-2015. Four characteristic states of the magnetosphere before and during a disturbance have been modeled: a quiet prestorm period, storm deepening phase with progressively decreasing SYM-H index, the storm maximum around the negative peak of SYM-H, and the recovery phase. Fitting the RBF model to data faithfully resolved contributions to the total magnetic field from all principal sources, including the westward and eastward ring current, the tail current, diamagnetic currents associated with the polar cusps, and the large-scale effect of the field-aligned currents. For two main phase conditions, the model field exhibited a strong dawn-dusk asymmetry of the low-latitude magnetic depression, extending to low altitudes and partly spreading sunward from the terminator plane in the dusk sector. The RBF model was found to resolve even finer details, such as the bifurcation of the innermost tail current. The method can be further developed into a powerful tool for data-based studies of the magnetospheric currents.

Detector Sampling of Optical/IR Spectra: How Many Pixels per FWHM?

NASA Astrophysics Data System (ADS)

Robertson, J. Gordon

2017-08-01

Most optical and IR spectra are now acquired using detectors with finite-width pixels in a square array. Each pixel records the received intensity integrated over its own area, and pixels are separated by the array pitch. This paper examines the effects of such pixellation, using computed simulations to illustrate the effects which most concern the astronomer end-user. It is shown that coarse sampling increases the random noise errors in wavelength by typically 10-20 % at 2 pixels per Full Width at Half Maximum, but with wide variation depending on the functional form of the instrumental Line Spread Function (i.e. the instrumental response to a monochromatic input) and on the pixel phase. If line widths are determined, they are even more strongly affected at low sampling frequencies. However, the noise in fitted peak amplitudes is minimally affected by pixellation, with increases less than about 5%. Pixellation has a substantial but complex effect on the ability to see a relative minimum between two closely spaced peaks (or relative maximum between two absorption lines). The consistent scale of resolving power presented by Robertson to overcome the inadequacy of the Full Width at Half Maximum as a resolution measure is here extended to cover pixellated spectra. The systematic bias errors in wavelength introduced by pixellation, independent of signal/noise ratio, are examined. While they may be negligible for smooth well-sampled symmetric Line Spread Functions, they are very sensitive to asymmetry and high spatial frequency sub-structure. The Modulation Transfer Function for sampled data is shown to give a useful indication of the extent of improperly sampled signal in an Line Spread Function. The common maxim that 2 pixels per Full Width at Half Maximum is the Nyquist limit is incorrect and most Line Spread Functions will exhibit some aliasing at this sample frequency. While 2 pixels per Full Width at Half Maximum is nevertheless often an acceptable minimum for moderate signal/noise work, it is preferable to carry out simulations for any actual or proposed Line Spread Function to find the effects of various sampling frequencies. Where spectrograph end-users have a choice of sampling frequencies, through on-chip binning and/or spectrograph configurations, it is desirable that the instrument user manual should include an examination of the effects of the various choices.

Optical polarization of high-energy BL Lacertae objects

NASA Astrophysics Data System (ADS)

Hovatta, T.; Lindfors, E.; Blinov, D.; Pavlidou, V.; Nilsson, K.; Kiehlmann, S.; Angelakis, E.; Fallah Ramazani, V.; Liodakis, I.; Myserlis, I.; Panopoulou, G. V.; Pursimo, T.

2016-12-01

Context. We investigate the optical polarization properties of high-energy BL Lac objects using data from the RoboPol blazar monitoring program and the Nordic Optical Telescope. Aims: We wish to understand if there are differences between the BL Lac objects that have been detected with the current-generation TeV instruments and those objects that have not yet been detected. Methods: We used a maximum-likelihood method to investigate the optical polarization fraction and its variability in these sources. In order to study the polarization position angle variability, we calculated the time derivative of the electric vector position angle (EVPA) change. We also studied the spread in the Stokes Q/I-U/I plane and rotations in the polarization plane. Results: The mean polarization fraction of the TeV-detected BL Lacs is 5%, while the non-TeV sources show a higher mean polarization fraction of 7%. This difference in polarization fraction disappears when the dilution by the unpolarized light of the host galaxy is accounted for. The TeV sources show somewhat lower fractional polarization variability amplitudes than the non-TeV sources. Also the fraction of sources with a smaller spread in the Q/I-U/I plane and a clumped distribution of points away from the origin, possibly indicating a preferred polarization angle, is larger in the TeV than in the non-TeV sources. These differences between TeV and non-TeV samples seem to arise from differences between intermediate and high spectral peaking sources instead of the TeV detection. When the EVPA variations are studied, the rate of EVPA change is similar in both samples. We detect significant EVPA rotations in both TeV and non-TeV sources, showing that rotations can occur in high spectral peaking BL Lac objects when the monitoring cadence is dense enough. Our simulations show that we cannot exclude a random walk origin for these rotations. Conclusions: These results indicate that there are no intrinsic differences in the polarization properties of the TeV-detected and non-TeV-detected high-energy BL Lac objects. This suggests that the polarization properties are not directly related to the TeV-detection, but instead the TeV loudness is connected to the general flaring activity, redshift, and the synchrotron peak location. The polarization curve data are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/596/A78

Intra‐annual variability of Silver Carp populations in the Des Moines River, USA

USGS Publications Warehouse

Sullivan, Christopher J.; Camacho, Carlos A.; Weber, Michael J.; Pierce, Clay

2017-01-01

Since their introduction in the 1970s, Silver Carp Hypophthalmichthys molitrix have spread throughout the Mississippi River basin. Management of any species relies on an accurate understanding of population characteristics and dynamics. However, Silver Carp seasonal sampling variation is unknown. Sampling during periods of peak catch rates would facilitate Silver Carp assessment and management, improving monitoring and removal techniques. The objective of this study was to evaluate adult Silver Carp seasonal sampling variation with boat electroshocking and trammel nets. Silver Carp were collected monthly (April–October) during 2014 and 2015 from four locations in the Des Moines River, Iowa. Trammel nets rarely captured Silver Carp (mean ± SE = 4.9 ± 1.6 fish/net; 60% of fish were captured in 6.3% of net sets) and therefore were not included in analyses. Electroshocking catch rates (CPUEs) exhibited a bimodal distribution, with peak CPUEs generally occurring in May, June, and September and lower catch rates observed during July and August. Catch rates were positively related to river discharge at upstream sites but not at downstream sites. Silver Carp size structure was similar among months and sites except at Cliffland, where fish were smaller during August and October compared to earlier in the year. Finally, Silver Carp condition peaked during April and May and decreased throughout the year except at Keokuk, where peaks were observed during both May and August. Although spatiotemporal variability was substantial, these results suggest that sampling of Silver Carp via electroshocking in May–June and September–October generally produces higher catch rates compared to July–August sampling and generates a more representative size structure. Using site‐specific knowledge, monitoring and surveillance programs could more effectively sample during these periods of high vulnerability and densities in order to manage the spread and impacts of Silver Carp at statewide and regionwide scales.

Assessment of the magnetic field exposure due to the battery current of digital mobile phones.

PubMed

Jokela, Kari; Puranen, Lauri; Sihvonen, Ari-Pekka

2004-01-01

Hand-held digital mobile phones generate pulsed magnetic fields associated with the battery current. The peak value and the waveform of the battery current were measured for seven different models of digital mobile phones, and the results were applied to compute approximately the magnetic flux density and induced currents in the phone-user's head. A simple circular loop model was used for the magnetic field source and a homogeneous sphere consisting of average brain tissue equivalent material simulated the head. The broadband magnetic flux density and the maximal induced current density were compared with the guidelines of ICNIRP using two various approaches. In the first approach the relative exposure was determined separately at each frequency and the exposure ratios were summed to obtain the total exposure (multiple-frequency rule). In the second approach the waveform was weighted in the time domain with a simple low-pass RC filter and the peak value was divided by a peak limit, both derived from the guidelines (weighted peak approach). With the maximum transmitting power (2 W) the measured peak current varied from 1 to 2.7 A. The ICNIRP exposure ratio based on the current density varied from 0.04 to 0.14 for the weighted peak approach and from 0.08 to 0.27 for the multiple-frequency rule. The latter values are considerably greater than the corresponding exposure ratios 0.005 (min) to 0.013 (max) obtained by applying the evaluation based on frequency components presented by the new IEEE standard. Hence, the exposure does not seem to exceed the guidelines. The computed peak magnetic flux density exceeded substantially the derived peak reference level of ICNIRP, but it should be noted that in a near-field exposure the external field strengths are not valid indicators of exposure. Currently, no biological data exist to give a reason for concern about the health effects of magnetic field pulses from mobile phones.

Quality Improvement of Cheese Spread

DTIC Science & Technology

2008-02-25

is a popular component used in the U.S. military feeding program in Meal , Ready to-Eat (MRE) rations. Currently, the military requires a 3-yr shelf...Rations, Cheese Spread, CORANET, Meal , Ready-to-Eat (MRE), Operational Rations, Unclassified U U U U 33 Lana Zivanovic 865-974-0844 ii Table of...program in Meal , Ready- to-Eat (MRE) rations. Currently, the military requires a 3-yr shelf life if stored at 80°F. However, due to product deployment

Increasing the Life of a Xenon-Ion Spacecraft Thruster

NASA Technical Reports Server (NTRS)

Goebel, Dan; Polk, James; Sengupta, Anita; Wirz, Richard

2007-01-01

A short document summarizes the redesign of a xenon-ion spacecraft thruster to increase its operational lifetime beyond a limit heretofore imposed by nonuniform ion-impact erosion of an accelerator electrode grid. A peak in the ion current density on the centerline of the thruster causes increased erosion in the center of the grid. The ion-current density in the NSTAR thruster that was the subject of this investigation was characterized by peak-to-average ratio of 2:1 and a peak-to-edge ratio of greater than 10:1. The redesign was directed toward distributing the same beam current more evenly over the entire grid andinvolved several modifications of the magnetic- field topography in the thruster to obtain more nearly uniform ionization. The net result of the redesign was to reduce the peak ion current density by nearly a factor of two, thereby halving the peak erosion rate and doubling the life of the thruster.

Analysis and Assessment of Peak Lightning Current Probabilities at the NASA Kennedy Space Center

NASA Technical Reports Server (NTRS)

Johnson, D. L.; Vaughan, W. W.

1999-01-01

This technical memorandum presents a summary by the Electromagnetics and Aerospace Environments Branch at the Marshall Space Flight Center of lightning characteristics and lightning criteria for the protection of aerospace vehicles. Probability estimates are included for certain lightning strikes (peak currents of 200, 100, and 50 kA) applicable to the National Aeronautics and Space Administration Space Shuttle at the Kennedy Space Center, Florida, during rollout, on-pad, and boost/launch phases. Results of an extensive literature search to compile information on this subject are presented in order to answer key questions posed by the Space Shuttle Program Office at the Johnson Space Center concerning peak lightning current probabilities if a vehicle is hit by a lightning cloud-to-ground stroke. Vehicle-triggered lightning probability estimates for the aforementioned peak currents are still being worked. Section 4.5, however, does provide some insight on estimating these same peaks.

Oceanic Lightning versus Continental Lightning: VLF Peak Current Discrepancies

NASA Astrophysics Data System (ADS)

Dupree, N. A., Jr.; Moore, R. C.

2015-12-01

Recent analysis of the Vaisala global lightning data set GLD360 suggests that oceanic lightning tends to exhibit larger peak currents than continental lightning (lightning occurring over land). The GLD360 peak current measurement is derived from distant measurements of the electromagnetic fields emanated during the lightning flash. Because the GLD360 peak current measurement is a derived quantity, it is not clear whether the actual peak currents of oceanic lightning tend to be larger, or whether the resulting electromagnetic field strengths tend to be larger. In this paper, we present simulations of VLF signal propagation in the Earth-ionosphere waveguide to demonstrate that the peak field values for oceanic lightning can be significantly stronger than for continental lightning. Modeling simulations are performed using the Long Wave Propagation Capability (LWPC) code to directly evaluate the effect of ground conductivity on VLF signal propagation in the 5-15 kHz band. LWPC is an inherently narrowband propagation code that has been modified to predict the broadband response of the Earth-Ionosphere waveguide to an impulsive lightning flash while preserving the ability of LWPC to account for an inhomogeneous waveguide. Furthermore, we evaluate the effect of return stroke speed on these results.

Regional patterns of mortality during the 1918 influenza pandemic in Newfoundland.

PubMed

Sattenspiel, Lisa

2011-07-22

The Spanish Influenza pandemic reached the island of Newfoundland in the summer of 1918 and by the time it disappeared, nearly 2000 of its 250,000 residents died. The pandemic spread in several waves, including a mild outbreak during the summer of 1918 (Wave I), a major, deadly outbreak in the succeeding fall and spring (Wave II), and a small echo wave in 1920. All parts of the island experienced the epidemic, but the effects varied across districts, both in timing and in severity. Overall P&I mortality rates across districts during the entire epidemic (1918-1920) ranged from 28.6 to 109.3 deaths per 10,000 population, with the island as a whole experiencing a mortality rate of 74.5 per 10,000. This island-wide mortality rate was 4.5 times higher than the P&I mortality rate for the 3 years immediately preceding the epidemic. Estimates of the reproduction number, R, range from 1.2 to 2.4 for Wave I and from 2.4 to 9.3 for Wave II. The pandemic experience on Newfoundland illustrates the high degree of regional variability in incidence and severity that epidemics can exhibit. In addition, compared to other world regions, the island's pandemic peaked relatively late and exhibited an unusual bimodal peak during Wave II, emphasizing that local and regional conditions can have major influences on timing, location, and rate of spread. This suggests the need to for greater understanding of how local factors influence epidemic spread so that more effective control strategies can be developed for populations experiencing future influenza pandemics. Copyright © 2011 Elsevier Ltd. All rights reserved.

Profiling of barrier capacitance and spreading resistance using a transient linearly increasing voltage technique.

PubMed

Gaubas, E; Ceponis, T; Kusakovskij, J

2011-08-01

A technique for the combined measurement of barrier capacitance and spreading resistance profiles using a linearly increasing voltage pulse is presented. The technique is based on the measurement and analysis of current transients, due to the barrier and diffusion capacitance, and the spreading resistance, between a needle probe and sample. To control the impact of deep traps in the barrier capacitance, a steady state bias illumination with infrared light was employed. Measurements of the spreading resistance and barrier capacitance profiles using a stepwise positioned probe on cross sectioned silicon pin diodes and pnp structures are presented.

Optically controlled resonant tunneling in a double-barrier diode

NASA Astrophysics Data System (ADS)

Kan, S. C.; Wu, S.; Sanders, S.; Griffel, G.; Yariv, A.

1991-03-01

The resonant tunneling effect is optically enhanced in a GaAs/GaAlAs double-barrier structure that has partial lateral current confinement. The peak current increases and the valley current decreases simultaneously when the device surface is illuminated, due to the increased conductivity of the top layer of the structure. The effect of the lateral current confinement on the current-voltage characteristic of a double-barrier resonant tunneling structure was also studied. With increased lateral current confinement, the peak and valley current decrease at a different rate such that the current peak-to-valley ratio increases up to three times. The experimental results are explained by solving the electrostatic potential distribution in the structure using a simple three-layer model.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Americo, Jeffrey L.; Sood, Cindy L.; Cotter, Catherine A.

Classical inbred mice are extensively used for virus research. However, we recently found that some wild-derived inbred mouse strains are more susceptible than classical strains to monkeypox virus. Experiments described here indicated that the 50% lethal dose of vaccinia virus (VACV) and cowpox virus (CPXV) were two logs lower in wild-derived inbred CAST/Ei mice than classical inbred BALB/c mice, whereas there was little difference in the susceptibility of the mouse strains to herpes simplex virus. Live bioluminescence imaging was used to follow spread of pathogenic and attenuated VACV strains and CPXV virus from nasal passages to organs in the chestmore » and abdomen of CAST/Ei mice. Luminescence increased first in the head and then simultaneously in the chest and abdomen in a dose-dependent manner. The spreading kinetics was more rapid with VACV than CPXV although the peak photon flux was similar. These data suggest advantages of CAST/Ei mice for orthopoxvirus studies. - Highlights: • Wild-derived inbred CAST/Ei mice are susceptible to vaccinia virus and cowpox virus. • Morbidity and mortality from orthopoxviruses are greater in CAST/Ei than BALB/c mice. • Morbidity and mortality from herpes simplex virus type 1 are similar in both mice. • Imaging shows virus spread from nose to lungs, abdominal organs and brain. • Vaccinia virus spreads more rapidly than cowpox virus.« less

Dynamics of movie competition and popularity spreading in recommender systems.

PubMed

Yeung, C H; Cimini, G; Jin, C-H

2011-01-01

We introduce a simple model to study movie competition in recommender systems. Movies of heterogeneous quality compete against each other through viewers' reviews and generate interesting dynamics at the box office. By assuming mean-field interactions between the competing movies, we show that the runaway effect of popularity spreading is triggered by defeating the average review score, leading to box-office hits: Popularity rises and peaks before fade-out. The average review score thus characterizes the critical movie quality necessary for transition from box-office bombs to blockbusters. The major factors affecting the critical review score are examined. By iterating the mean-field dynamical equations, we obtain qualitative agreements with simulations and real systems in the dynamical box-office forms, revealing the significant role of competition in understanding box-office dynamics.

Dynamics of movie competition and popularity spreading in recommender systems

NASA Astrophysics Data System (ADS)

Yeung, C. H.; Cimini, G.; Jin, C.-H.

2011-01-01

We introduce a simple model to study movie competition in recommender systems. Movies of heterogeneous quality compete against each other through viewers’ reviews and generate interesting dynamics at the box office. By assuming mean-field interactions between the competing movies, we show that the runaway effect of popularity spreading is triggered by defeating the average review score, leading to box-office hits: Popularity rises and peaks before fade-out. The average review score thus characterizes the critical movie quality necessary for transition from box-office bombs to blockbusters. The major factors affecting the critical review score are examined. By iterating the mean-field dynamical equations, we obtain qualitative agreements with simulations and real systems in the dynamical box-office forms, revealing the significant role of competition in understanding box-office dynamics.

Molten thermoplastic dripping behavior induced by flame spread over wire insulation under overload currents.

PubMed

He, Hao; Zhang, Qixing; Tu, Ran; Zhao, Luyao; Liu, Jia; Zhang, Yongming

2016-12-15

The dripping behavior of the molten thermoplastic insulation of copper wire, induced by flame spread under overload currents, was investigated for a better understanding of energized electrical wire fires. Three types of sample wire, with the same polyethylene insulation thickness and different core diameters, were used in this study. First, overload current effects on the transient one-dimensional wire temperature profile were predicted using simplified theoretical analysis; the heating process and equilibrium temperature were obtained. Second, experiments on the melting characteristics were conducted in a laboratory environment, including drop formation and frequency, falling speed, and combustion on the steel base. Third, a relationship between molten mass loss and volume variation was proposed to evaluate the dripping time and frequency. A strong current was a prerequisite for the wire dripping behavior and the averaged dripping frequency was found to be proportional to the square of the current based on the theoretical and experimental results. Finally, the influence of dripping behavior on the flame propagation along the energized electrical wire was discussed. The flame width, bright flame height and flame spreading velocity presented different behaviors. Copyright © 2016 Elsevier B.V. All rights reserved.

Multiple negative differential resistance devices with ultra-high peak-to-valley current ratio for practical multi-valued logic and memory applications

NASA Astrophysics Data System (ADS)

Shin, Sunhae; Rok Kim, Kyung

2015-06-01

In this paper, we propose a novel multiple negative differential resistance (NDR) device with ultra-high peak-to-valley current ratio (PVCR) over 106 by combining tunnel diode with a conventional MOSFET, which suppresses the valley current with transistor off-leakage level. Band-to-band tunneling (BTBT) in tunnel junction provides the first peak, and the second peak and valley are generated from the suppression of diffusion current in tunnel diode by the off-state MOSFET. The multiple NDR curves can be controlled by doping concentration of tunnel junction and the threshold voltage of MOSFET. By using complementary multiple NDR devices, five-state memory is demonstrated only with six transistors.

Epidemic spreading on hierarchical geographical networks with mobile agents

NASA Astrophysics Data System (ADS)

Han, Xiao-Pu; Zhao, Zhi-Dan; Hadzibeganovic, Tarik; Wang, Bing-Hong

2014-05-01

Hierarchical geographical traffic networks are critical for our understanding of scaling laws in human trajectories. Here, we investigate the susceptible-infected epidemic process evolving on hierarchical networks in which agents randomly walk along the edges and establish contacts in network nodes. We employ a metapopulation modeling framework that allows us to explore the contagion spread patterns in relation to multi-scale mobility behaviors. A series of computer simulations revealed that a shifted power-law-like negative relationship between the peak timing of epidemics τ0 and population density, and a logarithmic positive relationship between τ0 and the network size, can both be explained by the gradual enlargement of fluctuations in the spreading process. We employ a semi-analytical method to better understand the nature of these relationships and the role of pertinent demographic factors. Additionally, we provide a quantitative discussion of the efficiency of a border screening procedure in delaying epidemic outbreaks on hierarchical networks, yielding a rather limited feasibility of this mitigation strategy but also its non-trivial dependence on population density, infector detectability, and the diversity of the susceptible region. Our results suggest that the interplay between the human spatial dynamics, network topology, and demographic factors can have important consequences for the global spreading and control of infectious diseases. These findings provide novel insights into the combined effects of human mobility and the organization of geographical networks on spreading processes, with important implications for both epidemiological research and health policy.

Disease Localization in Multilayer Networks

NASA Astrophysics Data System (ADS)

de Arruda, Guilherme Ferraz; Cozzo, Emanuele; Peixoto, Tiago P.; Rodrigues, Francisco A.; Moreno, Yamir

2017-01-01

We present a continuous formulation of epidemic spreading on multilayer networks using a tensorial representation, extending the models of monoplex networks to this context. We derive analytical expressions for the epidemic threshold of the susceptible-infected-susceptible (SIS) and susceptible-infected-recovered dynamics, as well as upper and lower bounds for the disease prevalence in the steady state for the SIS scenario. Using the quasistationary state method, we numerically show the existence of disease localization and the emergence of two or more susceptibility peaks, which are characterized analytically and numerically through the inverse participation ratio. At variance with what is observed in single-layer networks, we show that disease localization takes place on the layers and not on the nodes of a given layer. Furthermore, when mapping the critical dynamics to an eigenvalue problem, we observe a characteristic transition in the eigenvalue spectra of the supra-contact tensor as a function of the ratio of two spreading rates: If the rate at which the disease spreads within a layer is comparable to the spreading rate across layers, the individual spectra of each layer merge with the coupling between layers. Finally, we report on an interesting phenomenon, the barrier effect; i.e., for a three-layer configuration, when the layer with the lowest eigenvalue is located at the center of the line, it can effectively act as a barrier to the disease. The formalism introduced here provides a unifying mathematical approach to disease contagion in multiplex systems, opening new possibilities for the study of spreading processes.

Lightning Characteristics and Lightning Strike Peak Current Probabilities as Related to Aerospace Vehicle Operations

NASA Technical Reports Server (NTRS)

Johnson, Dale L.; Vaughan, William W.

1998-01-01

A summary is presented of basic lightning characteristics/criteria for current and future NASA aerospace vehicles. The paper estimates the probability of occurrence of a 200 kA peak lightning return current, should lightning strike an aerospace vehicle in various operational phases, i.e., roll-out, on-pad, launch, reenter/land, and return-to-launch site. A literature search was conducted for previous work concerning occurrence and measurement of peak lighting currents, modeling, and estimating probabilities of launch vehicles/objects being struck by lightning. This paper presents these results.

Self-similar assemblies of globular whey proteins at the air-water interface: effect of the structure.

PubMed

Mahmoudi, Najet; Gaillard, Cédric; Boué, François; Axelos, Monique A V; Riaublanc, Alain

2010-05-01

We investigated the structure of heat-induced assemblies of whey globular proteins using small angle neutron scattering (SANS), static and dynamic light scattering (SLS and DLS), and cryogenic transmission electron microscopy (Cryo-TEM). Whey protein molecules self-assemble in fractal aggregates with a structure density depending on the electrostatic interactions. We determined the static and dynamic properties of interfacial layer formed by the protein assemblies, upon adsorption and spreading at the air-water interface using surface film balance and interfacial dilatational rheology. Upon spreading, all whey protein systems show a power-law scaling behavior of the surface pressure versus concentration in the semi-dilute surface concentration regime, with an exponent ranging from 5.5 to 9 depending on the electrostatic interactions and the aggregation state. The dilatational modulus derived from surface pressure isotherms shows a main peak at 6-8 mN/m, generally considered to be the onset of a conformational change in the monolayer, and a second peak or a shoulder at 15 mN/m. Long-time adsorption kinetics give similar results for both the native whey proteins and the corresponding self-similar assemblies, with a systematic effect of the ionic strength. Copyright 2010 Elsevier Inc. All rights reserved.

Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy.

PubMed

Kanai, T; Endo, M; Minohara, S; Miyahara, N; Koyama-ito, H; Tomura, H; Matsufuji, N; Futami, Y; Fukumura, A; Hiraoka, T; Furusawa, Y; Ando, K; Suzuki, M; Soga, F; Kawachi, K

1999-04-01

The irradiation system and biophysical characteristics of carbon beams are examined regarding radiation therapy. An irradiation system was developed for heavy-ion radiotherapy. Wobbler magnets and a scatterer were used for flattening the radiation field. A patient-positioning system using X ray and image intensifiers was also installed in the irradiation system. The depth-dose distributions of the carbon beams were modified to make a spread-out Bragg peak, which was designed based on the biophysical characteristics of monoenergetic beams. A dosimetry system for heavy-ion radiotherapy was established to deliver heavy-ion doses safely to the patients according to the treatment planning. A carbon beam of 80 keV/microm in the spread-out Bragg peak was found to be equivalent in biological responses to the neutron beam that is produced at cyclotron facility in National Institute Radiological Sciences (NIRS) by bombarding 30-MeV deuteron beam on beryllium target. The fractionation schedule of the NIRS neutron therapy was adapted for the first clinical trials using carbon beams. Carbon beams, 290, 350, and 400 MeV/u, were used for a clinical trial from June of 1994. Over 300 patients have already been treated by this irradiation system by the end of 1997.

Distortion correction of echo planar images applying the concept of finite rate of innovation to point spread function mapping (FRIP).

PubMed

Nunes, Rita G; Hajnal, Joseph V

2018-06-01

Point spread function (PSF) mapping enables estimating the displacement fields required for distortion correction of echo planar images. Recently, a highly accelerated approach was introduced for estimating displacements from the phase slope of under-sampled PSF mapping data. Sampling schemes with varying spacing were proposed requiring stepwise phase unwrapping. To avoid unwrapping errors, an alternative approach applying the concept of finite rate of innovation to PSF mapping (FRIP) is introduced, using a pattern search strategy to locate the PSF peak, and the two methods are compared. Fully sampled PSF data was acquired in six subjects at 3.0 T, and distortion maps were estimated after retrospective under-sampling. The two methods were compared for both previously published and newly optimized sampling patterns. Prospectively under-sampled data were also acquired. Shift maps were estimated and deviations relative to the fully sampled reference map were calculated. The best performance was achieved when using FRIP with a previously proposed sampling scheme. The two methods were comparable for the remaining schemes. The displacement field errors tended to be lower as the number of samples or their spacing increased. A robust method for estimating the position of the PSF peak has been introduced.

[Tularaemia - an overview of the current knowledge].

PubMed

Lukásová, Eva; Cermák, Pavel; Smelá, Gabriela; Jedlicková, Anna

2010-02-01

Francisella tularensis belongs to the family Francisellaceae. It is the aetiological agent of a zoonosis called tularaemia, spread throughout the northern hemisphere. Currently, several subspecies of F. tularensis may be distinguished with various pathogenicity and geographical distribution. In human medicine, only sporadic infections or local epidemics are reported. Given the fact that F. tularensis is highly pathogenic for humans and is easily spread by aerosol, water or food, it may be exploited as a biological weapon. It belongs to fastidious strains requiring specially prepared culture media.

Structural analysis of graphene and h-BN: A molecular dynamics approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thomas, Siby; Ajith, K. M., E-mail: ajith@nitk.ac.in; Valsakumar, M. C.

2016-05-06

Classical molecular dynamics simulation is employed to analyze pair correlations in graphene and h-BN at various temperatures to explore the integrity of their respective structures. As the temperature increases, the height fluctuations in the out-of-plane direction of both graphene and h-BN are found to increase. The positional spread of atoms also increases with temperature. Thus the amplitude of the peak positions in the radial distribution function (RDF) decreases with temperature. It is found that FWHM of peaks in the RDF of h-BN is smaller as compared to those of graphene which implies that the structure of h-BN is more robustmore » as compared to that of graphene with respect to their respective empirical potential.« less

Axial energy spread measurements of an accelerated positive ion beam

NASA Astrophysics Data System (ADS)

Lee, Y.; Gough, R. A.; Kunkel, W. B.; Leung, K. N.; Perkins, L. T.; Pickard, D. S.; Sun, L.; Vujic, J.; Williams, M. D.; Wutte, D.; Mondelli, Alfred A.; Stengl, Gerhard

1997-01-01

A multicusp ion source has been designed for use in ion projection lithography. Longitudinal energy spreads of the extracted positive hydrogen ion beam have been studied using a retarding field energy analyzer. It has been found that the filament-discharge multicusp ion source can deliver a beam with an energy spread less than 3 eV which is required for the ALG-1000 machine. The multicusp ion source can also deliver the current required for the application.

Spreading of lithium on a stainless steel surface at room temperature

DOE Office of Scientific and Technical Information (OSTI.GOV)

Skinner, C. H.; Capece, A. M.; Roszell, J. P.

Lithium conditioned plasma facing surfaces have lowered recycling and enhanced plasma performance on many fusion devices and liquid lithium plasma facing components are under consideration for future machines. A key factor in the performance of liquid lithium components is the wetting by lithium of its container. We have observed the surface spreading of lithium from a mm-scale particle to adjacent stainless steel surfaces using a scanning Auger microprobe that has elemental discrimination. Here, the spreading of lithium occurred at room temperature (when lithium is a solid) from one location at a speed of 0.62 μm/day under ultrahigh vacuum conditions. Separatemore » experiments using temperature programmed desorption (TPD) investigated bonding energetics between monolayer-scale films of lithium and stainless steel. While multilayer lithium desorption from stainless steel begins to occur just above 500 K (E des = 1.54 eV), sub-monolayer Li desorption occurred in a TPD peak at 942 K (E des = 2.52 eV) indicating more energetically favorable lithium-stainless steel bonding (in the absence of an oxidation layer) than lithium lithium bonding.« less

Spreading of lithium on a stainless steel surface at room temperature

DOE PAGES

Skinner, C. H.; Capece, A. M.; Roszell, J. P.; ...

2015-11-10

Lithium conditioned plasma facing surfaces have lowered recycling and enhanced plasma performance on many fusion devices and liquid lithium plasma facing components are under consideration for future machines. A key factor in the performance of liquid lithium components is the wetting by lithium of its container. We have observed the surface spreading of lithium from a mm-scale particle to adjacent stainless steel surfaces using a scanning Auger microprobe that has elemental discrimination. Here, the spreading of lithium occurred at room temperature (when lithium is a solid) from one location at a speed of 0.62 μm/day under ultrahigh vacuum conditions. Separatemore » experiments using temperature programmed desorption (TPD) investigated bonding energetics between monolayer-scale films of lithium and stainless steel. While multilayer lithium desorption from stainless steel begins to occur just above 500 K (E des = 1.54 eV), sub-monolayer Li desorption occurred in a TPD peak at 942 K (E des = 2.52 eV) indicating more energetically favorable lithium-stainless steel bonding (in the absence of an oxidation layer) than lithium lithium bonding.« less

Spreading of lithium on a stainless steel surface at room temperature

NASA Astrophysics Data System (ADS)

Skinner, C. H.; Capece, A. M.; Roszell, J. P.; Koel, B. E.

2016-01-01

Lithium conditioned plasma facing surfaces have lowered recycling and enhanced plasma performance on many fusion devices and liquid lithium plasma facing components are under consideration for future machines. A key factor in the performance of liquid lithium components is the wetting by lithium of its container. We have observed the surface spreading of lithium from a mm-scale particle to adjacent stainless steel surfaces using a scanning Auger microprobe that has elemental discrimination. The spreading of lithium occurred at room temperature (when lithium is a solid) from one location at a speed of 0.62 μm/day under ultrahigh vacuum conditions. Separate experiments using temperature programmed desorption (TPD) investigated bonding energetics between monolayer-scale films of lithium and stainless steel. While multilayer lithium desorption from stainless steel begins to occur just above 500 K (Edes = 1.54 eV), sub-monolayer Li desorption occurred in a TPD peak at 942 K (Edes = 2.52 eV) indicating more energetically favorable lithium-stainless steel bonding (in the absence of an oxidation layer) than lithium-lithium bonding.

InP tunnel junctions for InP/InGaAs tandem solar cells

NASA Technical Reports Server (NTRS)

Vilela, Mauro F.; Freundlich, Alex; Renaud, P.; Medelci, N.; Bensaoula, A.

1996-01-01

We report, for the first time, an epitaxially grown InP p(+)/n(++) tunnel junction. A diode with peak current densities up to 1600 A/cm and maximum specific resistivities (Vp/Ip - peak voltage to peak current ratio) in the range of 10(exp -4)Omega cm(exp 2) is obtained. This peak current density is comparable to the highest results previously reported for lattice matched In(0.53)Ga(0.47)As tunnel junctions. Both results were obtained using chemical beam epitaxy (CBE). In this paper we discuss the electrical characteristics of these tunnel diodes and how the growth conditions influence them.

InP Tunnel Junctions for InP/InGaAs Tandem Solar Cells

NASA Technical Reports Server (NTRS)

Vilela, M. F.; Medelci, N.; Bensaoula, A.; Freundlich, A.; Renaud, P.

1995-01-01

We report, for the first time, an epitaxially grown InP p(+)/n(++) tunnel junction. A diode with peak current densities up to 1600 Al/sq cm and maximum specific resistivities (Vp/lp - peak voltage to peak current ratio) in the range of 10(exp -4)Om sq cm is obtained. This peak current density is comparable to the highest results previously reported for lattice matched In(0.53)Ga(0.47)As tunnel junctions. Both results were obtained using chemical beam epitaxy (CBE). In this paper we discuss the electrical characteristics of these tunnel diodes and how the growth conditions influence them.

Growth and characterization of high current density, high-speed InAs/AlSb resonant tunneling diodes

NASA Technical Reports Server (NTRS)

Soderstrom, J. R.; Brown, E. R.; Parker, C. D.; Mahoney, L. J.; Yao, J. Y.

1991-01-01

InAs/AlSb double-barrier resonant tunneling diodes with peak current densities up to 370,000 A/sq cm and high peak-to-valley current ratios of 3.2 at room temperature have been fabricated. The peak current density is well-explained by a stationary-state transport model with the two-band envelope function approximation. The valley current density predicted by this model is less than the experimental value by a factor that is typical of the discrepancy found in other double-barrier structures. It is concluded that threading dislocations are largely inactive in the resonant tunneling process.

Narrow Energy Spread Protons and Ions from High-Intensity, High-Contrast Laser Solid Target Interactions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dollar, Franklin; Matsuoka, Takeshi; McGuffey, Christopher

2010-11-04

Recent simulations show that an idealized, high intensity, short pulse laser can generate quasi-monoenergetic proton beams with energies over 100 MeV in an interaction with a thin film. However, most short pulse laser facilities with sufficient intensity have difficulty controlling the nanosecond and picosecond contrast necessary to realize such a regime. Experiments were performed to investigate proton and ion acceleration from a high contrast, short pulse laser by employing dual plasma mirrors along with a deformable mirror at the HERCULES laser facility at the Center for Ultrafast Optical Sciences, University of Michigan. Plasma mirrors were characterized, allowing a 50% throughputmore » with an intensity contrast increase of 105. The focal spot quality was also exceptional, showing a 1.1 micron full width at half maximum (FWHM) focal diameter. Experiments were done using temporally cleaned 30 TW, 32 fs pulses to achieve an intensity of up to 10{sup 21} Wcm{sup -2} on Si{sub 3}N{sub 4} and Mylar targets with thicknesses ranging 50 nm to 13 microns. Proton beams with energy spreads below 2 MeV were observed from all thicknesses, peaking with energies up to 10.3 MeV and an energy spread of 0.8 MeV. Similar narrow energy spreads were observed for oxygen, nitrogen, and carbon at the silicon nitride thickness of 50 nm with energies up to 24 MeV with an energy spread of 3 MeV, whereas the energy spread is greatly increased at a larger thickness. Maximum energies were confirmed with CR39 track detectors, while a Thomson ion spectrometer was used to gauge the monoenergetic nature of the beam.« less

Dynamics of book sales: endogenous versus exogenous shocks in complex networks.

PubMed

Deschâtres, F; Sornette, D

2005-07-01

We present an extensive study of the foreshock and aftershock signatures accompanying peaks of book sales. The time series of book sales are derived from the ranking system of Amazon.com. We present two independent ways of classifying peaks, one based on the acceleration pattern of sales and the other based on the exponent of the relaxation. They are found to be consistent and reveal the coexistence of two types of sales peaks: exogenous peaks occur abruptly and are followed by a power law relaxation, while endogenous sale peaks occur after a progressively accelerating power law growth followed by an approximately symmetrical power law relaxation which is slower than for exogenous peaks. We develop a simple epidemic model of buyers connected within a network of acquaintances which propagates rumors and opinions on books. The comparison between the predictions of the model and the empirical data confirms the validity of the model and suggests in addition that social networks have evolved to converge very close to criticality (here in the sense of critical branching processes of opinion spreading). We test in detail the evidence for a power law distribution of book sales and confirm a previous indirect study suggesting that the fraction of books (density distribution) P (S) of sales S is a power law P(S) approximately 1/ S(1+mu) with mu approximately equal to 2 .

Dynamics of book sales: Endogenous versus exogenous shocks in complex networks

NASA Astrophysics Data System (ADS)

Deschâtres, F.; Sornette, D.

2005-07-01

We present an extensive study of the foreshock and aftershock signatures accompanying peaks of book sales. The time series of book sales are derived from the ranking system of Amazon.com. We present two independent ways of classifying peaks, one based on the acceleration pattern of sales and the other based on the exponent of the relaxation. They are found to be consistent and reveal the coexistence of two types of sales peaks: exogenous peaks occur abruptly and are followed by a power law relaxation, while endogenous sale peaks occur after a progressively accelerating power law growth followed by an approximately symmetrical power law relaxation which is slower than for exogenous peaks. We develop a simple epidemic model of buyers connected within a network of acquaintances which propagates rumors and opinions on books. The comparison between the predictions of the model and the empirical data confirms the validity of the model and suggests in addition that social networks have evolved to converge very close to criticality (here in the sense of critical branching processes of opinion spreading). We test in detail the evidence for a power law distribution of book sales and confirm a previous indirect study suggesting that the fraction of books (density distribution) P(S) of sales S is a power law P(S)˜1/S1+μ with μ≈2 .

Partial tripolar cochlear implant stimulation: Spread of excitation and forward masking in the inferior colliculus.

PubMed

Bierer, Julie Arenberg; Bierer, Steven M; Middlebrooks, John C

2010-12-01

This study examines patterns of neural activity in response to single biphasic electrical pulses, presented alone or following a forward masking pulse train, delivered by a cochlear implant. Recordings were made along the tonotopic axis of the central nucleus of the inferior colliculus (ICC) in ketamine/xylazine anesthetized guinea pigs. The partial tripolar electrode configuration was used, which provided a systematic way to vary the tonotopic extent of ICC activation between monopolar (broad) and tripolar (narrow) extremes while maintaining the same peak of activation. The forward masking paradigm consisted of a 200 ms masker pulse train (1017 pulses per second) followed 10 ms later by a single-pulse probe stimulus; the current fraction of the probe was set to 0 (monopolar), 1 (tripolar), or 0.5 (hybrid), and the fraction of the masker was fixed at 0.5. Forward masking tuning profiles were derived from the amount of masking current required to just suppress the activity produced by a fixed-level probe. These profiles were sharper for more focused probe configurations, approximating the pattern of neural activity elicited by single (non-masked) pulses. The result helps to bridge the gap between previous findings in animals and recent psychophysical data. Copyright © 2010 Elsevier B.V. All rights reserved.

Partial tripolar cochlear implant stimulation: Spread of excitation and forward masking in the inferior colliculus

PubMed Central

Bierer, Julie Arenberg; Bierer, Steven M.; Middlebrooks, John C.

2010-01-01

This study examines patterns of neural activity in response to single biphasic electrical pulses, presented alone or following a forward masking pulse train, delivered by a cochlear implant. Recordings were made along the tonotopic axis of the central nucleus of the inferior colliculus (ICC) in ketamine/xylazine anesthetized guinea pigs. The partial tripolar electrode configuration was used, which provided a systematic way to vary the tonotopic extent of ICC activation between monopolar (broad) and tripolar (narrow) extremes while maintaining the same peak of activation. The forward masking paradigm consisted of a 200-ms masker pulse train (1017 pulses per second) followed 10 ms later by a single-pulse probe stimulus; the current fraction of the probe was set to 0 (monopolar), 1 (tripolar), or 0.5 (hybrid), and the fraction of the masker was fixed at 0.5. Forward masking tuning profiles were derived from the amount of masking current required to just suppress the activity produced by a fixed-level probe. These profiles were sharper for more focused probe configurations, approximating the pattern of neural activity elicited by single (non-masked) pulses. The result helps to bridge the gap between previous findings in animals and recent psychophysical data. PMID:20727397

Movement patterns of nilgai antelope in South Texas: Implications for cattle fever tick management.

PubMed

Foley, Aaron M; Goolsby, John A; Ortega-S, Alfonso; Ortega-S, J Alfonso; Pérez de León, A; Singh, Nirbhay K; Schwartz, Andy; Ellis, Dee; Hewitt, David G; Campbell, Tyler A

2017-10-01

Wildlife, both native and introduced, can harbor and spread diseases of importance to the livestock industry. Describing movement patterns of such wildlife is essential to formulate effective disease management strategies. Nilgai antelope (Boselaphus tragocamelus) are a free-ranging, introduced ungulate in southern Texas known to carry cattle fever ticks (CFT, Rhipicephalus (Boophilus) microplus, R. (B.) annulatus). CFT are the vector for the etiological agent of bovine babesiosis, a lethal disease causing high mortality in susceptible Bos taurus populations and severely affecting the beef cattle industry. Efforts to eradicate CFT from the United States have been successful. However, a permanent quarantine area is maintained between Texas and Mexico to check its entry from infested areas of neighboring Mexico states on wildlife and stray cattle. In recent years, there has been an increase in CFT infestations outside of the permanent quarantine area in Texas. Nilgai are of interest in understanding how CFT may be spread through the landscape. Thirty nilgai of both sexes were captured and fitted with satellite radio collars in South Texas to gain information about movement patterns, response to disturbances, and movement barriers. Median annual home range sizes were highly variable in males (4665ha, range=571-20,809) and females (1606ha, range=848-29,909). Female movement patterns appeared to be seasonal with peaks during June-August; these peaks appeared to be a function of break-ups in female social groups rather than environmental conditions. Nilgai, which reportedly are sensitive to disturbance, were more likely to relocate into new areas immediately after being captured versus four other types of helicopter activities. Nilgai did not cross 1.25m high cattle fences parallel to paved highways but did cross other fence types. Results indicate that females have a higher chance of spreading CFT through the landscape than males, but spread of CFT may be mitigated via maintenance of cattle fences running parallel with paved highways. Our results highlight the importance of documenting species-specific behavior in wildlife-livestock interfaces that can be used to develop effective disease management strategies in the United States and worldwide. Published by Elsevier B.V.

Ischemia-induced spreading depolarization in the retina

PubMed Central

Srienc, Anja I; Biesecker, Kyle R; Shimoda, Angela M; Kur, Joanna

2016-01-01

Cortical spreading depolarization is a metabolically costly phenomenon that affects the brain in both health and disease. Following severe stroke, subarachnoid hemorrhage, or traumatic brain injury, cortical spreading depolarization exacerbates tissue damage and enlarges infarct volumes. It is not known, however, whether spreading depolarization also occurs in the retina in vivo. We report now that spreading depolarization episodes are generated in the in vivo rat retina following retinal vessel occlusion produced by photothrombosis. The properties of retinal spreading depolarization are similar to those of cortical spreading depolarization. Retinal spreading depolarization waves propagate at a velocity of 3.0 ± 0.1 mm/min and are associated with a negative shift in direct current potential, a transient cessation of neuronal spiking, arteriole constriction, and a decrease in tissue O2 tension. The frequency of retinal spreading depolarization generation in vivo is reduced by administration of the NMDA antagonist MK-801 and the 5-HT(1D) agonist sumatriptan. Branch retinal vein occlusion is a leading cause of vision loss from vascular disease. Our results suggest that retinal spreading depolarization could contribute to retinal damage in acute retinal ischemia and demonstrate that pharmacological agents can reduce retinal spreading depolarization frequency after retinal vessel occlusion. Blocking retinal spreading depolarization generation may represent a therapeutic strategy for preserving vision in branch retinal vein occlusion patients. PMID:27389181

The footprint of CO2 leakage in the water-column: Insights from numerical modeling based on a North Sea gas release experiment

NASA Astrophysics Data System (ADS)

Vielstädte, L.; Linke, P.; Schmidt, M.; Sommer, S.; Wallmann, K.; McGinnis, D. F.; Haeckel, M.

2013-12-01

Assessing the environmental impact of potential CO2 leakage from offshore carbon dioxide storage sites necessitates the investigation of the corresponding pH change in the water-column. Numerical models have been developed to simulate the buoyant rise and dissolution of CO2 bubbles in the water-column and the subsequent near-field dispersion of dissolved CO2 in seawater under ocean current and tidal forcing. In order to test and improve numerical models a gas release experiment has been conducted at 80 m water-depth within the Sleipner area (North Sea). CO2 and Kr (used as inert tracer gas) were released on top of a benthic lander at varying gas flows (<140 kg/day) and bubble sizes (de: 1-6 mm). pCO2 and pH were measured by in situ sensors to monitor the spread of the solute in different vertical heights and distances downstream of the artificial leak. The experiment and numerical analysis show that the impact of such leakage rates is limited to the near-field bottom waters, due to the rapid dissolution of CO2 bubbles in seawater (CO2 is being stripped within the first two to five meters of bubble rise). In particular, small bubbles, which will dissolve close to the seafloor, may cause a dangerous low-pH environment for the marine benthos. However, on the larger scale, the advective transport by e.g. tidal currents, dominates the CO2 dispersal in the North Sea and dilutes the CO2 peak quickly. The model results show that at the small scales (<100 m) of the CO2 plume the lateral eddy diffusion (~0.01 m2/s) has only a negligible effect. Overall, we can postulate that CO2 leakage at a rate of ~ 100 kg per day as in our experiment will only have a localized impact on the marine environment, thereby reducing pH substantially (by 0.4 units) within a diameter of less than 50 m around the release spot (depending on the duration of leakage and the current velocities). Strong currents and tidal cycles significantly reduce the spreading of low-pH water masses into the far-field by efficiently diluting the amount of CO2 in ambient seawater.

Hybrid epidemics--a case study on computer worm conficker.

PubMed

Zhang, Changwang; Zhou, Shi; Chain, Benjamin M

2015-01-01

Conficker is a computer worm that erupted on the Internet in 2008. It is unique in combining three different spreading strategies: local probing, neighbourhood probing, and global probing. We propose a mathematical model that combines three modes of spreading: local, neighbourhood, and global, to capture the worm's spreading behaviour. The parameters of the model are inferred directly from network data obtained during the first day of the Conficker epidemic. The model is then used to explore the tradeoff between spreading modes in determining the worm's effectiveness. Our results show that the Conficker epidemic is an example of a critically hybrid epidemic, in which the different modes of spreading in isolation do not lead to successful epidemics. Such hybrid spreading strategies may be used beneficially to provide the most effective strategies for promulgating information across a large population. When used maliciously, however, they can present a dangerous challenge to current internet security protocols.

Hybrid Epidemics—A Case Study on Computer Worm Conficker

PubMed Central

Zhang, Changwang; Zhou, Shi; Chain, Benjamin M.

2015-01-01

Conficker is a computer worm that erupted on the Internet in 2008. It is unique in combining three different spreading strategies: local probing, neighbourhood probing, and global probing. We propose a mathematical model that combines three modes of spreading: local, neighbourhood, and global, to capture the worm’s spreading behaviour. The parameters of the model are inferred directly from network data obtained during the first day of the Conficker epidemic. The model is then used to explore the tradeoff between spreading modes in determining the worm’s effectiveness. Our results show that the Conficker epidemic is an example of a critically hybrid epidemic, in which the different modes of spreading in isolation do not lead to successful epidemics. Such hybrid spreading strategies may be used beneficially to provide the most effective strategies for promulgating information across a large population. When used maliciously, however, they can present a dangerous challenge to current internet security protocols. PMID:25978309

Earth Observations taken by the Expedition 10 crew

NASA Image and Video Library

2004-11-22

ISS010-E-08224 (22 November 2004) --- Mount Olympus, Greece is featured in this image photographed by an Expedition 10 crewmember on the International Space Station (ISS). Mount Olympus is the highest peak (2917 meters) in Greece, as well as the mountain chain that runs north into Bulgaria and south, via the Cyclades Islands, into Turkey. In this winter view, Olympus is the only peak with a dusting of snow—perhaps for this reason its name in classical Greek means “the luminous one.” In Greek mythology the peak was inhabited by the Twelve Olympians, the most famous gods of the ancient Greeks. North of Mount Olympus lies Macedonia, the homeland of Alexander the Great. Climbing the mountain is a favorite tourist activity today. The slopes of the peaks of Olympus and its neighboring peaks drop sheer into the Thermaikos Gulf, a northern arm of the Aegean Sea. White cirrus clouds obscure the shoreline near the city of Thessaloniki. This major port is spread along the shores of a small and well protected bay at the north end of the gulf. On the plains inland of the Olympus chain lie a lake, on the Aliakmon River, and the town of Larisa, at the focus point of a series of transport routes.

InGaN laser diode with metal-free laser ridge using n+-GaN contact layers

NASA Astrophysics Data System (ADS)

Malinverni, Marco; Tardy, Camille; Rossetti, Marco; Castiglia, Antonino; Duelk, Marcus; Vélez, Christian; Martin, Denis; Grandjean, Nicolas

2016-06-01

We report on InGaN edge emitting laser diodes with a top metal electrode located beside the laser ridge. Current spreading over the ridge is achieved via a highly doped n+-type GaN layer deposited on top of the structure. The low sheet resistance of the n+-GaN layer ensures excellent lateral current spreading, while carrier injection is confined all along the ridge thanks to current tunneling at the interface between the n+-GaN top layer and the p++-GaN layer. Continuous-wave lasing at 400 nm with an output power of 100 mW is demonstrated on uncoated facet devices with a threshold current density of 2.4 kA·cm-2.

An Electronic Timer for Measuring Spread Rates of Wildland Fires

Treesearch

Richard W. Blank; Albert J. Simard

1983-01-01

There are many disadvantages to current techniques for measuring the spread rate of wildland fires. This paper describes the design and use of an electronic timber that resolves most of the problems. The unit is small, lightweight, inexpensive, easy-to-assemble, self-contained, and long-running.

Trichothecene-Genotypes Play a Role in Fusarium Head Blight Disease Spread and Trichothecene Accumulation in Wheat

USDA-ARS?s Scientific Manuscript database

In the current study, we evaluated the impact of the observed North American evolutionary shift in the Fusarium graminearum complex on disease spread, kernel damage, and trichothecene accumulation in resistant and susceptible wheat genotypes. Four inocula were prepared using composites of F. gramin...

Lightning Strike Peak Current Probabilities as Related to Space Shuttle Operations

NASA Technical Reports Server (NTRS)

Johnson, Dale L.; Vaughan, William W.

2000-01-01

A summary is presented of basic lightning characteristics/criteria applicable to current and future aerospace vehicles. The paper provides estimates on the probability of occurrence of a 200 kA peak lightning return current, should lightning strike an aerospace vehicle in various operational phases, i.e., roll-out, on-pad, launch, reenter/land, and return-to-launch site. A literature search was conducted for previous work concerning occurrence and measurement of peak lighting currents, modeling, and estimating the probabilities of launch vehicles/objects being struck by lightning. This paper presents a summary of these results.

Ridge of Jagged Peaks on Titan

NASA Image and Video Library

2016-07-29

This synthetic-aperture radar image was obtained by NASA's Cassini spacecraft during its T-120 pass over Titan's southern latitudes on June 7, 2016. The area shown here measures about 40 by 60 miles (70 by 100 kilometers) and is centered at about 60 degrees south latitude, 130 degrees west longitude. Radar illuminates the scene from the left at a 28-degree incidence angle. At the center of the image is a bright feature oriented from upper left to lower right. This is interpreted to be a long ridge with jagged peaks, likely created by methane rainfall erosion. Some of the individual peaks rise about 2,400 feet (800 meters) above the valley floor. The ridge has a considerably gentler slope on its left side (which appears brighter here) than on its right. Frequently, mountains shaped like this on Earth are fractured blocks of the planet's crust, thrusted upward and then tilted, creating a shallow slope on one side and a steeper slope on the fractured, faulted edge. Also presented here is an annotated version of the image, along with a radar image of the Dragoon Mountains in Arizona just east of Tucson. The Dragoon feature represents a tilted fault block, formed by spreading that has occurred across the western U.S., and has a similar shape to that of the Titan ridge. The Dragoon radar image was produced using data from NASA's Shuttle Radar Topography Mission (credit: NASA/JPL-Caltech/NGA). Radar illuminates the scene from the left in that image as well. Titan has displayed many features that are strikingly similar to Earth: lakes, seas, rivers, dunes and mountains. Scientists think it possible that, like Earth, the giant moon's crust has experienced familiar processes of uplift and spreading, followed by erosion. http://photojournal.jpl.nasa.gov/catalog/PIA20709

PLEIADES: a picosecond Compton scattering x-ray source for advanced backlighting and time-resolved material studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gibson, D J; Anderson, S G; Barty, C P

2003-10-20

The PLEIADES (Picosecond Laser-Electron Inter-Action for the Dynamical Evaluation of Structures) facility has produced first light at 70 keV. This milestone offers a new opportunity to develop laser-driven, compact, tunable x-ray sources for critical applications such as diagnostics for the National Ignition Facility and time-resolved material studies. The electron beam was focused to 50 {micro}m rms, at 57 MeV, with 260 C of charge, a relative energy spread of 0.2%, and a normalized emittance of 5 mm mrad horizontally and 13 mm mrad vertically. The scattered 820-nm laser pulse had an energy of 180 mJ and a duration of 54more » fs. Initial x-rays were captured with a cooled charge-coupled device using a Cesium Iodide scintillator; the peak photon energy was approximately 78 keV, with a total x-ray flux of 1.3 x 10{sup 6} photons/shot, and the observed angular distribution found to agree very well with three-dimensional codes. Simple K-edge radiography of a tantalum foil showed good agreement with the theoretical divergence-angle dependence of the x-ray energy. Optimization of the x-ray dose is currently underway, with the goal of reaching 10{sup 8} photons per shot and a peak brightness approaching 10{sup 20} photons/mm{sup 2}/mrad{sup 2}/s/0.1%bandwidth.« less

Demonstration of a 140-GHz 1-kW Confocal Gyro-Traveling-Wave Amplifier

PubMed Central

Joye, Colin D.; Shapiro, Michael A.; Sirigiri, Jagadishwar R.; Temkin, Richard J.

2009-01-01

The theory, design, and experimental results of a wideband 140-GHz 1-kW pulsed gyro-traveling-wave amplifier (gyro-TWA) are presented. The gyro-TWA operates in the HE06 mode of an overmoded quasi-optical waveguide using a gyrating electron beam. The electromagnetic theory, interaction theory, design processes, and experimental procedures are described in detail. At 37.7 kV and a 2.7-A beam current, the experiment has produced over 820 W of peak power with a –3-dB bandwidth of 0.8 GHz and a linear gain of 34 dB at 34.7 kV. In addition, the amplifier produced a –3-dB bandwidth of over 1.5 GHz (1.1%) with a peak power of 570 W from a 38.5-kV 2.5-A electron beam. The electron beam is estimated to have a pitch factor of 0.55–0.6, a radius of 1.9 mm, and a calculated perpendicular momentum spread of approximately 9%. The gyro-amplifier was nominally operated at a pulselength of 2 μs but was tested to amplify pulses as short as 4 ns with no noticeable pulse broadening. Internal reflections in the amplifier were identified using these short pulses by time-domain reflectometry. The demonstrated performance of this amplifier shows that it can be applied to dynamic nuclear polarization and electron paramagnetic resonance spectroscopy. PMID:20054451

Performances of the Alpha-X RF gun on the PHIL accelerator at LAL

NASA Astrophysics Data System (ADS)

Vinatier, T.; Bruni, C.; Roux, R.; Brossard, J.; Chancé, S.; Cayla, J. N.; Chaumat, V.; Xu, G.; Monard, H.

2015-10-01

The Alpha-X RF-gun was designed to produce an ultra-short (<100 fs rms), 100 pC and 6.3 MeV electron beam with a normalized rms transverse emittance of 1π mm mrad for a gun peak accelerating field of 100 MV/m. Such beams will be required by the Alpha-X project, which aims to study a laser-driven plasma accelerator with a short wavelength accelerating medium. It has been demonstrated on PHIL (Photo-Injector at LAL) that the coaxial RF coupling, chosen to preserve the gun field cylindrical symmetry, is perfectly understood and allows reaching the required peak accelerating field of 100 MV/m giving beam energy of 6.3 MeV. Moreover, a quite low beam rms relative energy spread of 0.15% at 3.8 MeV has been measured, completely agreeing with simulations. Dark current, quantum efficiencies and dephasing curves measurements have also been performed. They all show high values of the field enhancement factor β, which can be explained by the preparation of the photocathodes. Finally, measurements on the transverse phase-space have been carried out, with some limitations given by the difficult modelization of one of the PHIL solenoid magnets and by the enlargement of the beam transverse dimensions due to the use of YAG screens. These measurements give a normalized rms transverse emittance around 5π mm mrad, which does not fulfill the requirement for the Alpha-X project.

Genetic diversity, seasonality and transmission network of human metapneumovirus: identification of a unique sub-lineage of the fusion and attachment genes

PubMed Central

Chow, Wei Zhen; Chan, Yoke Fun; Oong, Xiang Yong; Ng, Liang Jie; Nor’E, Siti Sarah; Ng, Kim Tien; Chan, Kok Gan; Hanafi, Nik Sherina; Pang, Yong Kek; Kamarulzaman, Adeeba; Tee, Kok Keng

2016-01-01

Human metapneumovirus (HMPV) is an important viral respiratory pathogen worldwide. Current knowledge regarding the genetic diversity, seasonality and transmission dynamics of HMPV among adults and children living in tropical climate remains limited. HMPV prevailed at 2.2% (n = 86/3,935) among individuals presented with acute respiratory tract infections in Kuala Lumpur, Malaysia between 2012 and 2014. Seasonal peaks were observed during the northeast monsoon season (November–April) and correlated with higher relative humidity and number of rainy days (P < 0.05). Phylogenetic analysis of the fusion and attachment genes identified the co-circulation of three known HMPV sub-lineages, A2b and B1 (30.2% each, 26/86) and B2 (20.9%, 18/86), with genotype shift from sub-lineage B1 to A2b observed in 2013. Interestingly, a previously unrecognized sub-lineage of A2 was identified in 18.6% (16/86) of the population. Using a custom script for network construction based on the TN93 pairwise genetic distance, we identified up to nine HMPV transmission clusters circulating as multiple sub-epidemics. Although no apparent major outbreak was observed, the increased frequency of transmission clusters (dyads) during seasonal peaks suggests the potential roles of transmission clusters in driving the spread of HMPV. Our findings provide essential information for therapeutic research, prevention strategies, and disease outbreak monitoring of HMPV. PMID:27279080

The Seasonal Cycle of Water Vapour on Mars from Assimilation of Thermal Emission Spectrometer Data

NASA Technical Reports Server (NTRS)

Steele, Liam J.; Lewis, Stephen R.; Patel, Manish R.; Montmessin, Franck; Forget, Francois; Smith, Michael D.

2014-01-01

We present for the first time an assimilation of Thermal Emission Spectrometer (TES) water vapour column data into a Mars global climate model (MGCM). We discuss the seasonal cycle of water vapour, the processes responsible for the observed water vapour distribution, and the cross-hemispheric water transport. The assimilation scheme is shown to be robust in producing consistent reanalyses, and the global water vapour column error is reduced to around 2-4 pr micron depending on season. Wave activity is shown to play an important role in the water vapour distribution, with topographically steered flows around the Hellas and Argyre basins acting to increase transport in these regions in all seasons. At high northern latitudes, zonal wavenumber 1 and 2 stationary waves during northern summer are responsible for spreading the sublimed water vapour away from the pole. Transport by the zonal wavenumber 2 waves occurs primarily to the west of Tharsis and Arabia Terra and, combined with the effects of western boundary currents, this leads to peak water vapour column abundances here as observed by numerous spacecraft. A net transport of water to the northern hemisphere over the course of one Mars year is calculated, primarily because of the large northwards flux of water vapour which occurs during the local dust storm around L(sub S) = 240-260deg. Finally, outlying frost deposits that surround the north polar cap are shown to be important in creating the peak water vapour column abundances observed during northern summer.

Information spreading dynamics in hypernetworks

NASA Astrophysics Data System (ADS)

Suo, Qi; Guo, Jin-Li; Shen, Ai-Zhong

2018-04-01

Contact pattern and spreading strategy fundamentally influence the spread of information. Current mathematical methods largely assume that contacts between individuals are fixed by networks. In fact, individuals are affected by all his/her neighbors in different social relationships. Here, we develop a mathematical approach to depict the information spreading process in hypernetworks. Each individual is viewed as a node, and each social relationship containing the individual is viewed as a hyperedge. Based on SIS epidemic model, we construct two spreading models. One model is based on global transmission, corresponding to RP strategy. The other is based on local transmission, corresponding to CP strategy. These models can degenerate into complex network models with a special parameter. Thus hypernetwork models extend the traditional models and are more realistic. Further, we discuss the impact of parameters including structure parameters of hypernetwork, spreading rate, recovering rate as well as information seed on the models. Propagation time and density of informed nodes can reveal the overall trend of information dissemination. Comparing these two models, we find out that there is no spreading threshold in RP, while there exists a spreading threshold in CP. The RP strategy induces a broader and faster information spreading process under the same parameters.

Upper mantle electrical resistivity structure beneath back-arc spreading centers

NASA Astrophysics Data System (ADS)

Seama, N.; Shibata, Y.; Kimura, M.; Shindo, H.; Matsuno, T.; Nogi, Y.; Okino, K.

2011-12-01

We compare four electrical resistivity structure images of the upper mantle across back-arc spreading centers (Mariana Trough at 18 N and 13 N, and the Eastern Lau at 19.7 S and 21.3 S) to provide geophysical constraints on issues of mantle dynamics beneath the back-arc spreading system related to the subducting slab. The central Mariana Trough at 18 N has the full spreading rate of 25 km/Myr, and shows characteristic slow-spreading features; existence of median valley neovolcanic zone and "Bull's eyes" mantle Bouguer anomaly (MBA) along the axes. On the other hand, the southern Mariana Trough at 13 N shows an EPR type axial relief in morphology and lower MBA than that in the central Mariana Trough (Kitada et al., 2006), suggesting abundance of magma supply, even though the full spreading rate is 35 km/Myr that is categorized as a slow spreading ridge. At the Eastern Lau spreading center, crustal thickness and morphology vary systematically with arc proximity and shows the opposed trends against spreading rate: The full spreading rate increases from 65 km/Myr at 21.3 S to 85 km/Myr at 19.7 S, while the crustal thicknesses decrease together with morphology transitions from shallow peaked volcanic highs to a deeper flat axis (Martinez et al., 2006). Matsuno et al. (2010) provides a resistivity structure image of the upper mantle across the central Mariana subduction system, which contains several key features: There is an uppermost resistive layer with a thickness of 80-100 km beneath the central Mariana Trough, suggesting dry residual from the plate accretion process. But there is no evidence for a conductive feature beneath the back-arc spreading center at 18 N, and this feature is clearly independent from the conductive region beneath the volcanic arc below 60 km depth that reflects melting and hydration driven by water release from the subducting slab. The resultant upper mantle resistivity structure well support that the melt supply is not abundant, resulting in characteristic slow-spreading features at the surface. We have conducted marine magnetotelluric (MT) surveys at the southern Mariana in 2010 and at the Eastern Lau in 2009-2010. We obtained 10 ocean bottom electro-magnetometer (OBEM) data from a 130 km length MT transect across the southern Mariana spreading axis at 13 N, while we obtained 2 OBEM data and 11 ocean bottom magnetometer data from two 160 km length MT transects across the Eastern Lau spreading axes at 19.7 S and 21.3 S. After calculation of MT response functions and their correction for topographic distortion, two-dimensional electrical resistivity structures will be derived using an inversion algorithm. At this meeting, first we will show the resistivity structure images of the upper mantle beneath these spreading axes. Then, these structure images will be compared to identify differences in the mantle dynamics and the melt supply beneath the back-arc spreading system related to the subducting slab.

Extreme temperature robust optical sensor designs and fault-tolerant signal processing

DOEpatents

Riza, Nabeel Agha [Oviedo, FL; Perez, Frank [Tujunga, CA

2012-01-17

Silicon Carbide (SiC) probe designs for extreme temperature and pressure sensing uses a single crystal SiC optical chip encased in a sintered SiC material probe. The SiC chip may be protected for high temperature only use or exposed for both temperature and pressure sensing. Hybrid signal processing techniques allow fault-tolerant extreme temperature sensing. Wavelength peak-to-peak (or null-to-null) collective spectrum spread measurement to detect wavelength peak/null shift measurement forms a coarse-fine temperature measurement using broadband spectrum monitoring. The SiC probe frontend acts as a stable emissivity Black-body radiator and monitoring the shift in radiation spectrum enables a pyrometer. This application combines all-SiC pyrometry with thick SiC etalon laser interferometry within a free-spectral range to form a coarse-fine temperature measurement sensor. RF notch filtering techniques improve the sensitivity of the temperature measurement where fine spectral shift or spectrum measurements are needed to deduce temperature.

The Geology and Petrography of Crater Lake National Park

USGS Publications Warehouse

Diller, Joseph Silas; Patton, Horace Bushnell

1902-01-01

Origin of the name Mount Mazama - A great impetus to the spread of information concerning Crater Lake was given by the Mazamas of Portland, Oreg., who held a meeting at the lake in August, 1896, which attracted many visitors. The principal features in the history of the lake had previously been made out, and the Mazamas, recognizing the fact that the great peak which was nearly destroyed in preparing the pit for the lake had no name, gave it the name of their own society. Upon the rim of the lake are a number of small peaks, each having its own designation. The term Mount Mazama refers to the whole rim encircling the lake. It is but a mere remnant of the once lofty peak, the real Mount Mazama, which rose far into the region of eternal snow. To get a basis for reconstructing the original Mount Mazama it is necessary to study in detail the structure and composition of its foundation, now so attractively displayed in the encircling cliffs of Crater Lake.

Method for reducing peak phase current and decreasing staring time for an internal combustion engine having an induction machine

DOEpatents

Amey, David L.; Degner, Michael W.

2002-01-01

A method for reducing the starting time and reducing the peak phase currents for an internal combustion engine that is started using an induction machine starter/alternator. The starting time is reduced by pre-fluxing the induction machine and the peak phase currents are reduced by reducing the flux current command after a predetermined period of time has elapsed and concurrent to the application of the torque current command. The method of the present invention also provides a strategy for anticipating the start command for an internal combustion engine and determines a start strategy based on the start command and the operating state of the internal combustion engine.

Development of a Novel Rabies Simulation Model for Application in a Non-endemic Environment

PubMed Central

Dürr, Salome; Ward, Michael P.

2015-01-01

Domestic dog rabies is an endemic disease in large parts of the developing world and also epidemic in previously free regions. For example, it continues to spread in eastern Indonesia and currently threatens adjacent rabies-free regions with high densities of free-roaming dogs, including remote northern Australia. Mathematical and simulation disease models are useful tools to provide insights on the most effective control strategies and to inform policy decisions. Existing rabies models typically focus on long-term control programs in endemic countries. However, simulation models describing the dog rabies incursion scenario in regions where rabies is still exotic are lacking. We here describe such a stochastic, spatially explicit rabies simulation model that is based on individual dog information collected in two remote regions in northern Australia. Illustrative simulations produced plausible results with epidemic characteristics expected for rabies outbreaks in disease free regions (mean R0 1.7, epidemic peak 97 days post-incursion, vaccination as the most effective response strategy). Systematic sensitivity analysis identified that model outcomes were most sensitive to seven of the 30 model parameters tested. This model is suitable for exploring rabies spread and control before an incursion in populations of largely free-roaming dogs that live close together with their owners. It can be used for ad-hoc contingency or response planning prior to and shortly after incursion of dog rabies in previously free regions. One challenge that remains is model parameterisation, particularly how dogs’ roaming and contacts and biting behaviours change following a rabies incursion in a previously rabies free population. PMID:26114762

Evolution of human-driven fire regimes in Africa

PubMed Central

Archibald, Sally; Staver, A. Carla; Levin, Simon A.

2012-01-01

Human ability to manipulate fire and the landscape has increased over evolutionary time, but the impact of this on fire regimes and consequences for biodiversity and biogeochemistry are hotly debated. Reconstructing historical changes in human-derived fire regimes empirically is challenging, but information is available on the timing of key human innovations and on current human impacts on fire; here we incorporate this knowledge into a spatially explicit fire propagation model. We explore how changes in population density, the ability to create fire, and the expansion of agropastoralism altered the extent and seasonal distribution of fire as modern humans arose and spread through Africa. Much emphasis has been placed on the positive effect of population density on ignition frequency, but our model suggests this is less important than changes in fire spread and connectivity that would have occurred as humans learned to light fires in the dry season and to transform the landscape through grazing and cultivation. Different landscapes show different limitations; we show that substantial human impacts on burned area would only have started ∼4,000 B.P. in open landscapes, whereas they could have altered fire regimes in closed/dissected landscapes by ∼40,000 B.P. Dry season fires have been the norm for the past 200–300 ky across all landscapes. The annual area burned in Africa probably peaked between 4 and 40 kya. These results agree with recent paleocarbon studies that suggest that the biomass burned today is less than in the recent past in subtropical countries. PMID:22184249

Sleeping sickness in southeastern Uganda: a spatio-temporal analysis of disease risk, 1970-2003.

PubMed

Berrang-Ford, Lea; Berke, Olaf; Sweeney, Sean; Abdelrahman, Lubowa

2010-12-01

Sleeping sickness is a major threat to human health in sub-Saharan Africa. Southeastern Uganda has experienced a number of significant epidemics in the past 100 years, most recently from 1976 to 1989. Recent and continued spread of the disease has highlighted gaps in the ability of current research to explain and predict the distribution of infection. Vegetation cover and changes in vegetation may be important determinants of transmission and disease risk because of the habitat preferences of the tsetse fly vector. This study examines the determinants of sleeping sickness distribution and incidence in southeastern Uganda from 1970 to 2003, spanning the full epidemic region and cycle, and focusing in particular on vegetation cover and change. Sleeping sickness data were collected from records of the Ugandan Ministry of Health, individual sleeping sickness treatment centers, and interviews with public health officials. Vegetation data were acquired from satellite imagery for four dates spanning the epidemic period, 1973, 1986, 1995, and 2001. Zero-inflated regression models were used to model predictors of disease presence and magnitude. Correlations between disease incidence and the normalized difference vegetation index (NDVI) at the subcounty level were evaluated. Results indicate that sleeping sickness infection is predominantly associated with proximity to water and spatial location, while disease incidence is highest in subcounties with moderate to high NDVI. The vegetation density (NDVI) at which sleeping sickness incidence peaked differed throughout the study period. The optimal vegetation density capable of supporting sleeping sickness transmission may be lower than indicated by data from endemic regions, indicating increased potential for disease spread under suitable conditions.

Nowcasting the spread of chikungunya virus in the Americas.

PubMed

Johansson, Michael A; Powers, Ann M; Pesik, Nicki; Cohen, Nicole J; Staples, J Erin

2014-01-01

In December 2013, the first locally-acquired chikungunya virus (CHIKV) infections in the Americas were reported in the Caribbean. As of May 16, 55,992 cases had been reported and the outbreak was still spreading. Identification of newly affected locations is paramount to intervention activities, but challenging due to limitations of current data on the outbreak and on CHIKV transmission. We developed models to make probabilistic predictions of spread based on current data considering these limitations. Branching process models capturing travel patterns, local infection prevalence, climate dependent transmission factors, and associated uncertainty estimates were developed to predict probable locations for the arrival of CHIKV-infected travelers and for the initiation of local transmission. Many international cities and areas close to where transmission has already occurred were likely to have received infected travelers. Of the ten locations predicted to be the most likely locations for introduced CHIKV transmission in the first four months of the outbreak, eight had reported local cases by the end of April. Eight additional locations were likely to have had introduction leading to local transmission in April, but with substantial uncertainty. Branching process models can characterize the risk of CHIKV introduction and spread during the ongoing outbreak. Local transmission of CHIKV is currently likely in several Caribbean locations and possible, though uncertain, for other locations in the continental United States, Central America, and South America. This modeling framework may also be useful for other outbreaks where the risk of pathogen spread over heterogeneous transportation networks must be rapidly assessed on the basis of limited information.

[Epidemiologic and economic effectiveness of school closure during influenza epidemics and pandemics].

PubMed

Gendon, Iu Z; Vasil'ev, Iu M

2012-01-01

Epidemiologic and economic effectiveness of school closure during influenza epidemics and pandemics is discussed. Optimal effect of school closure is observed when this measure is taken at the start of the epidemic or pandemic and for a sufficiently long time. School closure during high morbidity among schoolchildren, in the middle (at the peak) and by the end of epidemic or pandemic does not influence significantly the spread of influenza or morbidity. Significant economic losses and other negative consequences of school closure are noted. School closure may be the most appropriate during the emergence of influenza pandemic when the pandemic vaccine is not yet available, however timely mass immunization of schoolchildren against influenza may be a more appropriate measure than school closure for the reduction of influenza morbidity and spread during seasonal influenza epidemics.

Submicrosecond characteristics of lightning return-stroke currents

NASA Technical Reports Server (NTRS)

Leteinturier, Christiane; Hamelin, Joel H.; Eybert-Berard, Andre

1991-01-01

The authors describe the experimental results obtained during 1987 and 1988 triggered-lightning experiments in Florida. Seventy-four simultaneous submicrosecond time-resolved measurements of triggered return-stroke current (I) and current derivative (dI/dt) were made in Florida in 1987 and 1988. Peak currents ranged from about 5 to 76 kA, peak dI/dt amplitude from 13 to 411 kA/microsec and rise time from 90 to 1000 ns. The mean peak dI/dt values of 110 kA/microsec were 2-3 times higher than data from instrumented towers and peak I and dI/dt appear to be positively correlated. These data confirm previous experiments and conclusions supported by forty measurements. They are important in order to define, for example, standards for lightning protection. Present standards give a dI/dt maximum of 140 kA/microsec.

Cloud-to-ground lightning flash characteristics from June 1984 through May 1985

NASA Technical Reports Server (NTRS)

Orville, Richard E.; Weisman, Robert A.; Pyle, Richard B.; Henderson, Ronald W.; Orville, Richard E., Jr.

1987-01-01

A magnetic direction-finding network for the detection of lightning cloud-to-ground strikes has been installed along the east coast of the United States. Time, location, flash polarity, stroke count, and peak signal amplitude are recorded in real time. The data were recorded from Maine to North Carolina and as far west as Ohio; analyses were restricted to flashes within 300 km of a direction finder. Measurements of peak signal strength have been obtained from 720,284 first return strokes lowering negative charge. The resulting distribution indicates that few negative strokes have peak currents exceeding 100 kA. Measurements have also been obtained of peak signal strength from 17,694 first return strokes lowering positive charge. These strokes have a median peak current of 45 kA, with some peak currents reaching 300-400 kA. The median peak signal strength and the peak current, double from summer to winter for both negative and positive first return strokes. The polarity of ground flashes is observed to be less than 5 percent positive throughout the summer and early fall, then increases to over 50 percent during the winter, and returns to less than 10 percent in early spring. The percent of positive flashes with one stroke is observed to be approximately 90 percent throughout the year. The percent of negative flashes with one stroke is observed to increase from 40 percent in the summer to approximately 80 percent in January, returning to less than 50 percent in the spring.

Design and testing of a magnetically driven implosion peak current diagnostic

NASA Astrophysics Data System (ADS)

Hess, M. H.; Peterson, K. J.; Ampleford, D. J.; Hutsel, B. T.; Jennings, C. A.; Gomez, M. R.; Dolan, D. H.; Robertson, G. K.; Payne, S. L.; Stygar, W. A.; Martin, M. R.; Sinars, D. B.

2018-04-01

A critical component of the magnetically driven implosion experiments at Sandia National Laboratories is the delivery of high-current, 10s of MA, from the Z pulsed power facility to a target. In order to assess the performance of the experiment, it is necessary to measure the current delivered to the target. Recent Magnetized Liner Inertial Fusion (MagLIF) experiments have included velocimetry diagnostics, such as PDV (Photonic Doppler Velocimetry) or Velocity Interferometer System for Any Reflector, in the final power feed section in order to infer the load current as a function of time. However, due to the nonlinear volumetrically distributed magnetic force within a velocimetry flyer, a complete time-dependent load current unfold is typically a time-intensive process and the uncertainties in the unfold can be difficult to assess. In this paper, we discuss how a PDV diagnostic can be simplified to obtain a peak current by sufficiently increasing the thickness of the flyer. This effectively keeps the magnetic force localized to the flyer surface, resulting in fast and highly accurate measurements of the peak load current. In addition, we show the results of experimental peak load current measurements from the PDV diagnostic in recent MagLIF experiments.

Astrocyte Sodium Signalling and Panglial Spread of Sodium Signals in Brain White Matter.

PubMed

Moshrefi-Ravasdjani, Behrouz; Hammel, Evelyn L; Kafitz, Karl W; Rose, Christine R

2017-09-01

In brain grey matter, excitatory synaptic transmission activates glutamate uptake into astrocytes, inducing sodium signals which propagate into neighboring astrocytes through gap junctions. These sodium signals have been suggested to serve an important role in neuro-metabolic coupling. So far, it is unknown if astrocytes in white matter-that is in brain regions devoid of synapses-are also able to undergo such intra- and intercellular sodium signalling. In the present study, we have addressed this question by performing quantitative sodium imaging in acute tissue slices of mouse corpus callosum. Focal application of glutamate induced sodium transients in SR101-positive astrocytes. These were largely unaltered in the presence of ionotropic glutamate receptors blockers, but strongly dampened upon pharmacological inhibition of glutamate uptake. Sodium signals induced in individual astrocytes readily spread into neighboring SR101-positive cells with peak amplitudes decaying monoexponentially with distance from the stimulated cell. In addition, spread of sodium was largely unaltered during pharmacological inhibition of purinergic and glutamate receptors, indicating gap junction-mediated, passive diffusion of sodium between astrocytes. Using cell-type-specific, transgenic reporter mice, we found that sodium signals also propagated, albeit less effectively, from astrocytes to neighboring oligodendrocytes and NG2 cells. Again, panglial spread was unaltered with purinergic and glutamate receptors blocked. Taken together, our results demonstrate that activation of sodium-dependent glutamate transporters induces sodium signals in white matter astrocytes, which spread within the astrocyte syncytium. In addition, we found a panglial passage of sodium signals from astrocytes to NG2 cells and oligodendrocytes, indicating functional coupling between these macroglial cells in white matter.

Photoelectric return-stroke velocity and peak current estimates in natural and triggered lightning

NASA Technical Reports Server (NTRS)

Mach, Douglas M.; Rust, W. David

1989-01-01

Two-dimensional photoelectric return stroke velocities from 130 strokes are presented, including 86 negative natural, 41 negative triggered, one positive triggered, and two positive natural return strokes. For strokes starting near the ground and exceeding 500 m in length, the average velocity is 1.3 + or - 0.3 X 10 to the 8th m/s for natural return strokes and 1.2 + or - 0.3 X 10 to the 8th m/s for triggered return strokes. For strokes with lengths less than 500 m, the average velocities are slightly higher. Using the transmission line model (TLM), the shortest segment one-dimensional return stroke velocity, and either the maximum or plateau electric field, it is shown that natural strokes have a peak current distribution that is lognormal with a median value of 16 kA (maximum E) or 12 kA (plateau E). Triggered lightning has a medium peak current value of 21 kA (maximum E) or 15 kA (plateau E). Correlations are found between TLM peak currents and velocities for triggered and natural subsequent return strokes, but not between TLM peak currents and natural first return stroke velocities.

Challenges Encountered by a Distance Learning Organisation

ERIC Educational Resources Information Center

Malik, Sangeeta

2012-01-01

Distance learning as the name indicates is a learning, learner gets from distant places. In this learning system, learner and educators are separated by space & time. Lots of distance learning organizations are spreading to meet the increased demand of current & future needs of adult education. The rapid spread of these organizations doesn't mean…

The effect of nutritional spray regimes on orange juice quality in relation to juice Las DNA detection

USDA-ARS?s Scientific Manuscript database

Huanglongbing (HLB) has been spreading statewide in Florida. Removal of infected trees is the most effective way to control spread of the disease. However, under the current decreasing production trend(annual production down from 220 million boxes before two severe hurricane seasons in 2004 and 20...

Controlling Gas-Phase Reactions for Efficient Charge Reduction Electrospray Mass Spectrometry of Intact Proteins

PubMed Central

Frey, Brian L.; Lin, Yuan; Westphall, Michael S.; Smith, Lloyd M.

2006-01-01

Charge reduction electrospray mass spectrometry (CREMS) reduces the charge states of electrospray-generated ions, which concentrates the ions from a protein into fewer peaks spread over a larger m/z range, thereby increasing peak separation and decreasing spectral congestion. An optimized design for a CREMS source is described that provides an order-of-magnitude increase in sensitivity compared to previous designs and provides control over the extent of charge reduction. Either a corona discharge or an α-particle source was employed to generate anions that abstract protons from electrosprayed protein cations. These desired ion/ion proton transfer reactions predominated, but some oxidation and ion-attachment reactions also occurred leading to new peaks or mass-shifted broader peaks while decreasing signal intensity. The species producing these deleterious side-reactions were identified, and conditions were found that prevented their formation. Spectrometer m/z biases were examined because of their effect upon the signal intensity of higher m/z charge-reduced protein ions. The utility of this atmospheric pressure CREMS was demonstrated using a cell lysate fraction from E. coli. The spectral simplification afforded by CREMS reveals more proteins than are observed without charge reduction. PMID:16198118

Online Measurement of the Energy Spread of Multi-Turn Beam in the Fermilab Booster at Injection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nelson, J.; Bhat, C. M.; Hendricks, B. S.

We have developed a computer program interfaced with the ACNET environment of Fermilab accelerators to measure energy spread of the proton beam from the LINAC at an injection into the Booster. It uses a digitizing oscilloscope and provides users an ability to configure the scope settings for optimal data acquisition from a resistive wall current monitor. When the program is launched, a) a one shot timeline is generated to initiate beam injection into the Booster, b) a gap of about 40 ns is produced in the injected beam using a set of fast kickers, c) collects line charge distribution datamore » from the wall current monitor for the first 200 μs from the injection and d) performs complete data analysis to extract full beam energy spread of the beam. The program also gives the option to store the data for offline analyses. We illustrate a case with an example. We also present results on beam energy spread as a function of beam intensity from recent measurements.« less

Modeling mountain pine beetle habitat suitability within Sequoia National Park

NASA Astrophysics Data System (ADS)

Nguyen, Andrew

Understanding significant changes in climate and their effects on timber resources can help forest managers make better decisions regarding the preservation of natural resources and land management. These changes may to alter natural ecosystems dependent on historical and current climate conditions. Increasing mountain pine beetle (MBP) outbreaks within the southern Sierra Nevada are the result of these alterations. This study better understands MPB behavior within Sequoia National Park (SNP) and model its current and future habitat distribution. Variables contributing to MPB spread are vegetation stress, soil moisture, temperature, precipitation, disturbance, and presence of Ponderosa (Pinus ponderosa) and Lodgepole (Pinus contorta) pine trees. These variables were obtained using various modeled, insitu, and remotely sensed sources. The generalized additive model (GAM) was used to calculate the statistical significance of each variable contributing to MPB spread and also created maps identifying habitat suitability. Results indicate vegetation stress and forest disturbance to be variables most indicative of MPB spread. Additionally, the model was able to detect habitat suitability of MPB with a 45% accuracy concluding that a geospatial driven modeling approach can be used to delineate potential MPB spread within SNP.

Suppressing epidemic spreading by risk-averse migration in dynamical networks

NASA Astrophysics Data System (ADS)

Yang, Han-Xin; Tang, Ming; Wang, Zhen

2018-01-01

In this paper, we study the interplay between individual behaviors and epidemic spreading in a dynamical network. We distribute agents on a square-shaped region with periodic boundary conditions. Every agent is regarded as a node of the network and a wireless link is established between two agents if their geographical distance is less than a certain radius. At each time, every agent assesses the epidemic situation and make decisions on whether it should stay in or leave its current place. An agent will leave its current place with a speed if the number of infected neighbors reaches or exceeds a critical value E. Owing to the movement of agents, the network's structure is dynamical. Interestingly, we find that there exists an optimal value of E leading to the maximum epidemic threshold. This means that epidemic spreading can be effectively controlled by risk-averse migration. Besides, we find that the epidemic threshold increases as the recovering rate increases, decreases as the contact radius increases, and is maximized by an optimal moving speed. Our findings offer a deeper understanding of epidemic spreading in dynamical networks.

Simulation of emittance dilution in electron storage ring from Compton backscattering

NASA Astrophysics Data System (ADS)

Blumberg, L. N.; Blum, E.

A Monte-Carlo simulation of Compton backscattered kappa(sub L) = 3.2-micron photons from an IR-FEL on 75-MeV electrons in a storage ring yields an RMS electron energy spread of delta(sub E) = 11.9-keV for a sample of 10(exp 7) single scattering events. Electrons are sampled from a beam of natural energy spread sigma(sub E) = 5.6-keV and damped transverse angle spreads sigma(sub x)(prime) = .041-mrad and sigma(sub y)(prime) = .052-mrad (100%) coupling, scaled from the 200-MeV BNL XLS compact storage ring. The Compton-scattered x-rays are generated from an integral of the CM Klein-Nishina cross-section transformed to the lab. A tracking calculation has also been performed in 6-dimensional phase space. Initial electron coordinates are selected randomly from a Gaussian distribution of RMS spreads sigma(sub xo) = .102-mm, sigma(sub x(prime)o) = .041-mrad, sigma(sub yo) = .018-mm, sigma(sub y(prime)o) = .052-mrad, sigma(sub (phi)o) = 22-mrad and sigma(sub Eo) = 6-keV. A sample of 10000 electrons were each following for 40000 turns around the ring through an RF cavity of f(sub RF) = 211.54-MHz and peak voltage V(sub m)=300-keV. Preliminary results indicate that the resulting energy distribution is quite broad with an RMS width of delta(sub E) = 124-keV. The transverse widths are only slightly increased from their original values, i.e. delta(sub x) = .106-mm and delta(sub x)(prime) = .043 mrad. The scaled energy spread of delta(sub E) approximately = 360-keV for approximately 350,000 turns desired in a 10-msec x-ray angiography exposure is well within the RF bucket used here; even V(sub m) less than 50-kV is adequate. Further, the electron energy spread adds a negligible RMS x-ray energy spread of delta(sub Ex) = .32-keV. The electron energy damping time of tau(sub E) = 379-msec at 75-MeV in an XLS-type ring allows for damping this induced spread and top-off of the ring between heart cycles.

SU-FF-T-668: A Simple Algorithm for Range Modulation Wheel Design in Proton Therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nie, X; Nazaryan, Vahagn; Gueye, Paul

2009-06-01

Purpose: To develop a simple algorithm in designing the range modulation wheel to generate a very smooth Spread-Out Bragg peak (SOBP) for proton therapy.Method and Materials: A simple algorithm has been developed to generate the weight factors in corresponding pristine Bragg peaks which composed a smooth SOBP in proton therapy. We used a modified analytical Bragg peak function based on Monte Carol simulation tool-kits of Geant4 as pristine Bragg peaks input in our algorithm. A simple METLAB(R) Quad Program was introduced to optimize the cost function in our algorithm. Results: We found out that the existed analytical function of Braggmore » peak can't directly use as pristine Bragg peak dose-depth profile input file in optimization of the weight factors since this model didn't take into account of the scattering factors introducing from the range shifts in modifying the proton beam energies. We have done Geant4 simulations for proton energy of 63.4 MeV with a 1.08 cm SOBP for variation of pristine Bragg peaks which composed this SOBP and modified the existed analytical Bragg peak functions for their peak heights, ranges of R{sub 0}, and Gaussian energies {sigma}{sub E}. We found out that 19 pristine Bragg peaks are enough to achieve a flatness of 1.5% of SOBP which is the best flatness in the publications. Conclusion: This work develops a simple algorithm to generate the weight factors which is used to design a range modulation wheel to generate a smooth SOBP in protonradiation therapy. We have found out that a medium number of pristine Bragg peaks are enough to generate a SOBP with flatness less than 2%. It is potential to generate data base to store in the treatment plan to produce a clinic acceptable SOBP by using our simple algorithm.« less

Domestic dog roaming patterns in remote northern Australian indigenous communities and implications for disease modelling.

PubMed

Hudson, Emily G; Brookes, Victoria J; Dürr, Salome; Ward, Michael P

2017-10-01

Although Australia is canine rabies free, the Northern Peninsula Area (NPA), Queensland and other northern Australian communities are at risk of an incursion due to proximity to rabies infected islands of Indonesia and existing disease spread pathways. Northern Australia also has large populations of free-roaming domestic dogs, presenting a risk of rabies establishment and maintenance should an incursion occur. Agent-based rabies spread models are being used to predict potential outbreak size and identify effective control strategies to aid incursion preparedness. A key component of these models is knowledge of dog roaming patterns to inform contact rates. However, a comprehensive understanding of how dogs utilise their environment and the heterogeneity of their movements to estimate contact rates is lacking. Using a novel simulation approach - and GPS data collected from 21 free-roaming domestic dogs in the NPA in 2014 and 2016 - we characterised the roaming patterns within this dog population. Multiple subsets from each individual dog's GPS dataset were selected representing different monitoring durations and a utilisation distribution (UD) and derived core (50%) and extended (95%) home ranges (HR) were estimated for each duration. Three roaming patterns were identified, based on changes in mean HR over increased monitoring durations, supported by assessment of maps of daily UDs of each dog. Stay-at-home dogs consolidated their HR around their owner's residence, resulting in a decrease in mean HR (both core and extended) as monitoring duration increased (median peak core and extended HR 0.336 and 3.696ha, respectively). Roamer dogs consolidated their core HR but their extended HR increased with longer monitoring durations, suggesting that their roaming patterns based on place of residence were more variable (median peak core and extended HR 0.391 and 6.049ha, respectively). Explorer dogs demonstrated large variability in their roaming patterns, with both core and extended HR increasing as monitoring duration increased (median peak core and extended HR 0.650 and 9.520ha, respectively). These findings are likely driven by multiple factors that have not been further investigated within this study. Different roaming patterns suggest heterogeneous contact rates between dogs in this population. These findings will be incorporated into disease-spread modelling to more realistically represent roaming patterns and improve model predictions. Copyright © 2017 Elsevier B.V. All rights reserved.

The negative ultraslow potential, electrophysiological correlate of infarction in the human cortex

PubMed Central

Lückl, Janos; Lemale, Coline L; Kola, Vasilis; Horst, Viktor; Khojasteh, Uldus; Oliveira-Ferreira, Ana I; Major, Sebastian; Winkler, Maren K L; Kang, Eun-Jeung; Schoknecht, Karl; Martus, Peter; Hartings, Jed A; Woitzik, Johannes

2018-01-01

Abstract Spreading depolarizations are characterized by abrupt, near-complete breakdown of the transmembrane ion gradients, neuronal oedema, mitochondrial depolarization, glutamate excitotoxicity and activity loss (depression). Spreading depolarization induces either transient hyperperfusion in normal tissue; or hypoperfusion (inverse coupling = spreading ischaemia) in tissue at risk for progressive injury. The concept of the spreading depolarization continuum is critical since many spreading depolarizations have intermediate characteristics, as opposed to the two extremes of spreading depolarization in either severely ischaemic or normal tissue. In animals, the spreading depolarization extreme in ischaemic tissue is characterized by prolonged depolarization durations, in addition to a slow baseline variation termed the negative ultraslow potential. The negative ultraslow potential is initiated by spreading depolarization and similar to the negative direct current (DC) shift of prolonged spreading depolarization, but specifically refers to a negative potential component during progressive recruitment of neurons into cell death in the wake of spreading depolarization. We here first quantified the spreading depolarization-initiated negative ultraslow potential in the electrocorticographic DC range and the activity depression in the alternate current range after middle cerebral artery occlusion in rats. Relevance of these variables to the injury was supported by significant correlations with the cortical infarct volume and neurological outcome after 72 h of survival. We then identified negative ultraslow potential-containing clusters of spreading depolarizations in 11 patients with aneurysmal subarachnoid haemorrhage. The human platinum/iridium-recorded negative ultraslow potential showed a tent-like shape. Its amplitude of 45.0 (39.0, 69.4) mV [median (first, third quartile)] was 6.6 times larger and its duration of 3.7 (3.3, 5.3) h was 34.9 times longer than the negative DC shift of spreading depolarizations in less compromised tissue. Using Generalized Estimating Equations applied to a logistic regression model, we found that negative ultraslow potential displaying electrodes were significantly more likely to overlie a developing ischaemic lesion (90.0%, 27/30) than those not displaying a negative ultraslow potential (0.0%, 0/20) (P = 0.004). Based on serial neuroimages, the lesions under the electrodes developed within a time window of 72 (56, 134) h. The negative ultraslow potential occurred in this time window in 9/10 patients. It was often preceded by a spreading depolarization cluster with increasingly persistent spreading depressions and progressively prolonged DC shifts and spreading ischaemias. During the negative ultraslow potential, spreading ischaemia lasted for 40.0 (28.0, 76.5) min, cerebral blood flow fell from 57 (53, 65) % to 26 (16, 42) % (n = 4) and tissue partial pressure of oxygen from 12.5 (9.2, 15.2) to 3.3 (2.4, 7.4) mmHg (n = 5). Our data suggest that the negative ultraslow potential is the electrophysiological correlate of infarction in human cerebral cortex and a neuromonitoring-detected medical emergency. PMID:29668855

The negative ultraslow potential, electrophysiological correlate of infarction in the human cortex.

PubMed

Lückl, Janos; Lemale, Coline L; Kola, Vasilis; Horst, Viktor; Khojasteh, Uldus; Oliveira-Ferreira, Ana I; Major, Sebastian; Winkler, Maren K L; Kang, Eun-Jeung; Schoknecht, Karl; Martus, Peter; Hartings, Jed A; Woitzik, Johannes; Dreier, Jens P

2018-06-01

Spreading depolarizations are characterized by abrupt, near-complete breakdown of the transmembrane ion gradients, neuronal oedema, mitochondrial depolarization, glutamate excitotoxicity and activity loss (depression). Spreading depolarization induces either transient hyperperfusion in normal tissue; or hypoperfusion (inverse coupling = spreading ischaemia) in tissue at risk for progressive injury. The concept of the spreading depolarization continuum is critical since many spreading depolarizations have intermediate characteristics, as opposed to the two extremes of spreading depolarization in either severely ischaemic or normal tissue. In animals, the spreading depolarization extreme in ischaemic tissue is characterized by prolonged depolarization durations, in addition to a slow baseline variation termed the negative ultraslow potential. The negative ultraslow potential is initiated by spreading depolarization and similar to the negative direct current (DC) shift of prolonged spreading depolarization, but specifically refers to a negative potential component during progressive recruitment of neurons into cell death in the wake of spreading depolarization. We here first quantified the spreading depolarization-initiated negative ultraslow potential in the electrocorticographic DC range and the activity depression in the alternate current range after middle cerebral artery occlusion in rats. Relevance of these variables to the injury was supported by significant correlations with the cortical infarct volume and neurological outcome after 72 h of survival. We then identified negative ultraslow potential-containing clusters of spreading depolarizations in 11 patients with aneurysmal subarachnoid haemorrhage. The human platinum/iridium-recorded negative ultraslow potential showed a tent-like shape. Its amplitude of 45.0 (39.0, 69.4) mV [median (first, third quartile)] was 6.6 times larger and its duration of 3.7 (3.3, 5.3) h was 34.9 times longer than the negative DC shift of spreading depolarizations in less compromised tissue. Using Generalized Estimating Equations applied to a logistic regression model, we found that negative ultraslow potential displaying electrodes were significantly more likely to overlie a developing ischaemic lesion (90.0%, 27/30) than those not displaying a negative ultraslow potential (0.0%, 0/20) (P = 0.004). Based on serial neuroimages, the lesions under the electrodes developed within a time window of 72 (56, 134) h. The negative ultraslow potential occurred in this time window in 9/10 patients. It was often preceded by a spreading depolarization cluster with increasingly persistent spreading depressions and progressively prolonged DC shifts and spreading ischaemias. During the negative ultraslow potential, spreading ischaemia lasted for 40.0 (28.0, 76.5) min, cerebral blood flow fell from 57 (53, 65) % to 26 (16, 42) % (n = 4) and tissue partial pressure of oxygen from 12.5 (9.2, 15.2) to 3.3 (2.4, 7.4) mmHg (n = 5). Our data suggest that the negative ultraslow potential is the electrophysiological correlate of infarction in human cerebral cortex and a neuromonitoring-detected medical emergency.awy102media15775596049001.

Cytoskeletal filament assembly and the control of cell spreading and function by extracellular matrix

NASA Technical Reports Server (NTRS)

Mooney, D. J.; Langer, R.; Ingber, D. E.

1995-01-01

This study was undertaken to analyze how cell binding to extracellular matrix produces changes in cell shape. We focused on the initial process of cell spreading that follows cell attachment to matrix and, thus, cell 'shape' changes are defined here in terms of alterations in projected cell areas, as determined by computerized image analysis. Cell spreading kinetics and changes in microtubule and actin microfilament mass were simultaneously quantitated in hepatocytes plated on different extracellular matrix substrata. The initial rate of cell spreading was highly dependent on the matrix coating density and decreased from 740 microns 2/h to 50 microns 2/h as the coating density was lowered from 1000 to 1 ng/cm2. At approximately 4 to 6 hours after plating, this initial rapid spreading rate slowed and became independent of the matrix density regardless of whether laminin, fibronectin, type I collagen or type IV collagen was used for cell attachment. Analysis of F-actin mass revealed that cell adhesion to extracellular matrix resulted in a 20-fold increase in polymerized actin within 30 minutes after plating, before any significant change in cell shape was observed. This was followed by a phase of actin microfilament disassembly which correlated with the most rapid phase of cell extension and ended at about 6 hours; F-actin mass remained relatively constant during the slow matrix-independent spreading phase. Microtubule mass increased more slowly in spreading cells, peaking at 4 hours, the time at which the transition between rapid and slow spreading rates was observed. However, inhibition of this early rise in microtubule mass using either nocodazole or cycloheximide did not prevent this transition. Use of cytochalasin D revealed that microfilament integrity was absolutely required for hepatocyte spreading whereas interference with microtubule assembly (using nocodazole or taxol) or protein synthesis (using cycloheximide) only partially suppressed cell extension. In contrast, cell spreading could be completely inhibited by combining suboptimal doses of cytochalasin D and nocodazole, suggesting that intact microtubules can stabilize cell form when the microfilament lattice is partially compromised. The physiological relevance of the cytoskeleton and cell shape in hepatocyte physiology was highlighted by the finding that a short exposure (6 hour) of cells to nocodazole resulted in production of smaller cells 42 hours later that exhibited enhanced production of a liver-specific product (albumin). These data demonstrate that spreading and flattening of the entire cell body is not driven directly by net polymerization of either microfilaments or microtubules.(ABSTRACT TRUNCATED AT 400 WORDS).

Elliptical spreading characteristics of a liquid metal droplet impact on a glass surface under a horizontal magnetic field

NASA Astrophysics Data System (ADS)

Yang, Juan-Cheng; Qi, Tian-Yu; Han, Tian-Yang; Zhang, Jie; Ni, Ming-Jiu

2018-01-01

The spreading characteristics of a liquid GaInSn alloy droplet on a glass surface with the action of a horizontal magnetic field have been experimentally investigated in the present paper. With changing the impact velocity from 0.1 m/s to 1.2 m/s and increasing the magnetic field from 0 T to 1.6 T, we focus on studying the influence of the horizontal magnetic field on the spreading characteristics of a liquid metal droplet using the shadow-graph method. The elliptical spreading pattern of a liquid metal droplet induced by the horizontal magnetic field was discovered by experiments. By introducing a numerical method in getting the distribution of current lines and the Lorentz force inside the droplet, we give a detailed explanation on the mechanism of elliptical spreading. Furthermore, some quantitative results on a maximum spreading factor and time at moment of maximum spreading varied with the Hartmann number and Weber number are shown to give us a comprehensive understanding of the elliptical spreading. With the increasing of the magnetic field, the maximum spreading factor in the front view is reduced while that in the side view is increased, which reveals a larger deformation happened during the spreading process. While with the increasing of impact velocity, the spreading factor increased. Finally, we present a non-dimensional parameter to get scaling laws for the averaged maximum spreading factor and the aspect ratio of the maximum spreading factor; results show that the predict data can agree with experimental data in a certain degree.

Particle distributions in approximately 10(13) - 10(16) eV air shower cores at mountain altitude and comparison with Monte Carlo simulations

NASA Technical Reports Server (NTRS)

Ash, A. G.

1985-01-01

Photographs of 521 shower cores in an array of current-limited spark (discharge) chambers at Sacramento Peak (2900m above sea level, 730 g /sq cm.), New Mexico, U.S.A., have been analyzed and the results compared with similar data from Leeds (80m above sea level, 1020 g sq cm.). It was found that the central density differential spectrum is consistent with a power law index of -2 up to approx. 1500/sq m where it steepens, and that shower cores become flatter on average with increasing size. Scaling model predictions for proton primaries with a approx E sup -2.71 energy spectrum account well for the altitude dependence of the data at lower densities. However, deviations at higher densities indicate a change in hadron interaction characteristics between approx few x 10 to the 14th power and 10 to the 15th power eV primary energy causing particles close to the shower axis to be spread further out.

High-efficiency acceleration in the laser wakefield by a linearly increasing plasma density

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dong, Kegong; Wu, Yuchi; Zhu, Bin

The acceleration length and the peak energy of the electron beam are limited by the dephasing effect in the laser wakefield acceleration with uniform plasma density. Based on 2D-3V particle in cell simulations, the effects of a linearly increasing plasma density on the electron acceleration are investigated broadly. Comparing with the uniform plasma density, because of the prolongation of the acceleration length and the gradually increasing accelerating field due to the increasing plasma density, the electron beam energy is twice higher in moderate nonlinear wakefield regime. Because of the lower plasma density, the linearly increasing plasma density can also avoidmore » the dark current caused by additional injection. At the optimal acceleration length, the electron energy can be increased from 350 MeV (uniform) to 760 MeV (linearly increasing) with the energy spread of 1.8%, the beam duration is 5 fs and the beam waist is 1.25 μm. This linearly increasing plasma density distribution can be achieved by a capillary with special gas-filled structure, and is much more suitable for experiment.« less

Forecasting Influenza Epidemics in Hong Kong.

PubMed

Yang, Wan; Cowling, Benjamin J; Lau, Eric H Y; Shaman, Jeffrey

2015-07-01

Recent advances in mathematical modeling and inference methodologies have enabled development of systems capable of forecasting seasonal influenza epidemics in temperate regions in real-time. However, in subtropical and tropical regions, influenza epidemics can occur throughout the year, making routine forecast of influenza more challenging. Here we develop and report forecast systems that are able to predict irregular non-seasonal influenza epidemics, using either the ensemble adjustment Kalman filter or a modified particle filter in conjunction with a susceptible-infected-recovered (SIR) model. We applied these model-filter systems to retrospectively forecast influenza epidemics in Hong Kong from January 1998 to December 2013, including the 2009 pandemic. The forecast systems were able to forecast both the peak timing and peak magnitude for 44 epidemics in 16 years caused by individual influenza strains (i.e., seasonal influenza A(H1N1), pandemic A(H1N1), A(H3N2), and B), as well as 19 aggregate epidemics caused by one or more of these influenza strains. Average forecast accuracies were 37% (for both peak timing and magnitude) at 1-3 week leads, and 51% (peak timing) and 50% (peak magnitude) at 0 lead. Forecast accuracy increased as the spread of a given forecast ensemble decreased; the forecast accuracy for peak timing (peak magnitude) increased up to 43% (45%) for H1N1, 93% (89%) for H3N2, and 53% (68%) for influenza B at 1-3 week leads. These findings suggest that accurate forecasts can be made at least 3 weeks in advance for subtropical and tropical regions.

Forecasting Influenza Epidemics in Hong Kong

PubMed Central

Yang, Wan; Cowling, Benjamin J.; Lau, Eric H. Y.; Shaman, Jeffrey

2015-01-01

Recent advances in mathematical modeling and inference methodologies have enabled development of systems capable of forecasting seasonal influenza epidemics in temperate regions in real-time. However, in subtropical and tropical regions, influenza epidemics can occur throughout the year, making routine forecast of influenza more challenging. Here we develop and report forecast systems that are able to predict irregular non-seasonal influenza epidemics, using either the ensemble adjustment Kalman filter or a modified particle filter in conjunction with a susceptible-infected-recovered (SIR) model. We applied these model-filter systems to retrospectively forecast influenza epidemics in Hong Kong from January 1998 to December 2013, including the 2009 pandemic. The forecast systems were able to forecast both the peak timing and peak magnitude for 44 epidemics in 16 years caused by individual influenza strains (i.e., seasonal influenza A(H1N1), pandemic A(H1N1), A(H3N2), and B), as well as 19 aggregate epidemics caused by one or more of these influenza strains. Average forecast accuracies were 37% (for both peak timing and magnitude) at 1-3 week leads, and 51% (peak timing) and 50% (peak magnitude) at 0 lead. Forecast accuracy increased as the spread of a given forecast ensemble decreased; the forecast accuracy for peak timing (peak magnitude) increased up to 43% (45%) for H1N1, 93% (89%) for H3N2, and 53% (68%) for influenza B at 1-3 week leads. These findings suggest that accurate forecasts can be made at least 3 weeks in advance for subtropical and tropical regions. PMID:26226185

[Cortical spreading depolarization: a new pathophysiological mechanism in neurological diseases].

PubMed

Sánchez-Porras, Renán; Robles-Cabrera, Adriana; Santos, Edgar

2014-05-20

Cortical spreading depolarization is a wave of almost complete depolarization of the neuronal and glial cells that occurs in different neurological diseases such as migraine with aura, subarachnoid hemorrhage, intracerebral hemorrhage, head trauma and stroke. These depolarization waves are characterized by a change in the negative potential with an amplitude between -10 and -30mV, duration of ∼1min and changes in the ion homeostasis between the intra- and extracellular space. This results in neuronal edema and dendritic distortion. Under pathologic states of hypoperfusion, cortical spreading depolarization can produce oxidative stress, worsen hypoxia and induce neuronal death. This is due to intense arterial vasoconstriction produced by an inverse response called spreading ischemia. Only in the last years there has been an electrophysiological confirmation of cortical spreading depolarization in human brains. Occurrence of cortical spreading depolarization has been associated with worse outcome in patients. Currently, increased knowledge regarding the pathophysiologic mechanisms supports the hypothetical correlation of cortical spreading depolarization with brain damage in humans. There are diverse therapeutic alternatives that promise inhibition of cortical spreading depolarization and subsequent better outcomes. Copyright © 2013 Elsevier España, S.L. All rights reserved.

Correlated observations of three triggered lightning flashes

NASA Technical Reports Server (NTRS)

Idone, V. P.; Orville, R. E.; Hubert, P.; Barret, L.; Eybert-Berard, A.

1984-01-01

Three triggered lightning flashes, initiated during the Thunderstorm Research International Program (1981) at Langmuir Laboratory, New Mexico, are examined on the basis of three-dimensional return stroke propagation speeds and peak currents. Nonlinear relationships result between return stroke propagation speed and stroke peak current for 56 strokes, and between return stroke propagation speed and dart leader propagation speed for 32 strokes. Calculated linear correlation coefficients include dart leader propagation speed and ensuing return stroke peak current (32 strokes; r = 0.84); and stroke peak current and interstroke interval (69 strokes; r = 0.57). Earlier natural lightning data do not concur with the weak positive correlation between dart leader propagation speed and interstroke interval. Therefore, application of triggered lightning results to natural lightning phenomena must be made with certain caveats. Mean values are included for the three-dimensional return stroke propagation speed and for the three-dimensional dart leader propagation speed.

Operational head-on beam-beam compensation with electron lenses in the Relativistic Heavy Ion Collider

DOE PAGES

Fischer, W.; Gu, X.; Altinbas, Z.; ...

2015-12-23

Head-on beam-beam compensation has been implemented in the Relativistic Heavy Ion Collider (RHIC) in order to increase the luminosity delivered to the experiments. We discuss the principle of combining a lattice for resonance driving term compensation and an electron lens for tune spread compensation. We describe the electron lens technology and its operational use. As of this date the implemented compensation scheme approximately doubled the peak and average luminosities.

Characterisation of the Hamamatsu photomultipliers for the KM3NeT Neutrino Telescope

NASA Astrophysics Data System (ADS)

Aiello, S.; Akrame, S. E.; Ameli, F.; Anassontzis, E. G.; Andre, M.; Androulakis, G.; Anghinolfi, M.; Anton, G.; Ardid, M.; Aublin, J.; Avgitas, T.; Baars, M.; Bagatelas, C.; Barbarino, G.; Baret, B.; Barrios-Martí, J.; Belias, A.; Berbee, E.; van den Berg, A.; Bertin, V.; Biagi, S.; Biagioni, A.; Biernoth, C.; Bormuth, R.; Boumaaza, J.; Bourret, S.; Bouwhuis, M.; Bozza, C.; Brânzaş, H.; Briukhanova, N.; Bruijn, R.; Brunner, J.; Buis, E.; Buompane, R.; Busto, J.; Calvo, D.; Capone, A.; Caramete, L.; Celli, S.; Chabab, M.; Cherubini, S.; Chiarella, V.; Chiarusi, T.; Circella, M.; Cocimano, R.; Coelho, J. A. B.; Coleiro, A.; Colomer Molla, M.; Coniglione, R.; Coyle, P.; Creusot, A.; Cuttone, G.; D'Onofrio, A.; Dallier, R.; De Sio, C.; Di Palma, I.; Díaz, A. F.; Distefano, C.; Domi, A.; Donà, R.; Donzaud, C.; Dornic, D.; Dörr, M.; Durocher, M.; Eberl, T.; van Eijk, D.; El Bojaddaini, I.; Elsaesser, D.; Enzenhöfer, A.; Ferrara, G.; Fusco, L. A.; Gal, T.; Garufi, F.; Gauchery, S.; Geißelsöder, S.; Gialanella, L.; Giorgio, E.; Giuliante, A.; Gozzini, S. R.; Ruiz, R. Gracia; Graf, K.; Grasso, D.; Grégoire, T.; Grella, G.; Hallmann, S.; van Haren, H.; Heid, T.; Heijboer, A.; Hekalo, A.; Hernández-Rey, J. J.; Hofestädt, J.; Illuminati, G.; James, C. W.; Jongen, M.; Jongewaard, B.; de Jong, M.; de Jong, P.; Kadler, M.; Kalaczyński, P.; Kalekin, O.; Katz, U. F.; Chowdhury, N. R. Khan; Kieft, G.; Kießling, D.; Koffeman, E. N.; Kooijman, P.; Kouchner, A.; Kreter, M.; Kulikovskiy, V.; Lahmann, R.; Le Breton, R.; Leone, F.; Leonora, E.; Levi, G.; Lincetto, M.; Lonardo, A.; Longhitano, F.; Lotze, M.; Loucatos, S.; Maggi, G.; Mańczak, J.; Mannheim, K.; Margiotta, A.; Marinelli, A.; Markou, C.; Martin, L.; Martínez-Mora, J. A.; Martini, A.; Marzaioli, F.; Mele, R.; Melis, K. W.; Migliozzi, P.; Migneco, E.; Mijakowski, P.; Miranda, L. S.; Mollo, C. M.; Morganti, M.; Moser, M.; Moussa, A.; Muller, R.; Musumeci, M.; Nauta, L.; Navas, S.; Nicolau, C. A.; Nielsen, C.; Organokov, M.; Orlando, A.; Panagopoulos, V.; Papalashvili, G.; Papaleo, R.; Păvălaş, G. E.; Pellegrini, G.; Pellegrino, C.; Pérez Romero, J.; Perrin-Terrin, M.; Piattelli, P.; Pikounis, K.; Pisanti, O.; Poirè, C.; Polydefki, G.; Poma, G. E.; Popa, V.; Post, M.; Pradier, T.; Pühlhofer, G.; Pulvirenti, S.; Quinn, L.; Raffaelli, F.; Randazzo, N.; Razzaque, S.; Real, D.; Resvanis, L.; Reubelt, J.; Riccobene, G.; Richer, M.; Rovelli, A.; Salvadori, I.; Samtleben, D. F. E.; Sánchez Losa, A.; Sanguineti, M.; Santangelo, A.; Sapienza, P.; Schermer, B.; Sciacca, V.; Seneca, J.; Sgura, I.; Shanidze, R.; Sharma, A.; Simeone, F.; Sinopoulou, A.; Spisso, B.; Spurio, M.; Stavropoulos, D.; Steijger, J.; Stellacci, S. M.; Strandberg, B.; Stransky, D.; Stüven, T.; Taiuti, M.; Tatone, F.; Tayalati, Y.; Tenllado, E.; Thakore, T.; Timmer, P.; Trovato, A.; Tsagkli, S.; Tzamariudaki, E.; Tzanetatos, D.; Valieri, C.; Vallage, B.; Van Elewyck, V.; Versari, F.; Viola, S.; Vivolo, D.; Volkert, M.; de Waardt, L.; Wilms, J.; de Wolf, E.; Zaborov, D.; Zornoza, J. D.; Zúñiga, J.

2018-05-01

The Hamamatsu R12199-02 3-inch photomultiplier tube is the photodetector chosen for the first phase of the KM3NeT neutrino telescope. About 7000 photomultipliers have been characterised for dark count rate, timing spread and spurious pulses. The quantum efficiency, the gain and the peak-to-valley ratio have also been measured for a sub-sample in order to determine parameter values needed as input to numerical simulations of the detector.

Segmented Mirror Image Degradation Due to Surface Dust, Alignment and Figure

NASA Technical Reports Server (NTRS)

Schreur, Julian J.

1999-01-01

In 1996 an algorithm was developed to include the effects of surface roughness in the calculation of the point spread function of a telescope mirror. This algorithm has been extended to include the effects of alignment errors and figure errors for the individual elements, and an overall contamination by surface dust. The final algorithm builds an array for a guard-banded pupil function of a mirror that may or may not have a central hole, a central reflecting segment, or an outer ring of segments. The central hole, central reflecting segment, and outer ring may be circular or polygonal, and the outer segments may have trimmed comers. The modeled point spread functions show that x-tilt and y-tilt, or the corresponding R-tilt and theta-tilt for a segment in an outer ring, is readily apparent for maximum wavefront errors of 0.1 lambda. A similar sized piston error is also apparent, but integral wavelength piston errors are not. Severe piston error introduces a focus error of the opposite sign, so piston could be adjusted to compensate for segments with varying focal lengths. Dust affects the image principally by decreasing the Strehl ratio, or peak intensity of the image. For an eight-meter telescope a 25% coverage by dust produced a scattered light intensity of 10(exp -9) of the peak intensity, a level well below detectability.

Carrier Estimation Using Classic Spectral Estimation Techniques for the Proposed Demand Assignment Multiple Access Service

NASA Technical Reports Server (NTRS)

Scaife, Bradley James

1999-01-01

In any satellite communication, the Doppler shift associated with the satellite's position and velocity must be calculated in order to determine the carrier frequency. If the satellite state vector is unknown then some estimate must be formed of the Doppler-shifted carrier frequency. One elementary technique is to examine the signal spectrum and base the estimate on the dominant spectral component. If, however, the carrier is spread (as in most satellite communications) this technique may fail unless the chip rate-to-data rate ratio (processing gain) associated with the carrier is small. In this case, there may be enough spectral energy to allow peak detection against a noise background. In this thesis, we present a method to estimate the frequency (without knowledge of the Doppler shift) of a spread-spectrum carrier assuming a small processing gain and binary-phase shift keying (BPSK) modulation. Our method relies on an averaged discrete Fourier transform along with peak detection on spectral match filtered data. We provide theory and simulation results indicating the accuracy of this method. In addition, we will describe an all-digital hardware design based around a Motorola DSP56303 and high-speed A/D which implements this technique in real-time. The hardware design is to be used in NMSU's implementation of NASA's demand assignment, multiple access (DAMA) service.

Selection of patients for heart transplantation in the current era of heart failure therapy.

PubMed

Butler, Javed; Khadim, Ghazanfar; Paul, Kimberly M; Davis, Stacy F; Kronenberg, Marvin W; Chomsky, Don B; Pierson, Richard N; Wilson, John R

2004-03-03

We sought to assess the relationship between survival, peak exercise oxygen consumption (VO(2)), and heart failure survival score (HFSS) in the current era of heart failure (HF) therapy. Based on predicted survival, HF patients with peak VO(2) <14 ml/min/kg or medium- to high-risk HFSS are currently considered eligible for heart transplantation. However, these criteria were developed before the widespread use of beta-blockers, spironolactone, and defibrillators-interventions known to improve the survival of HF patients. Peak VO(2) and HFSS were assessed in 320 patients followed from 1994 to 1997 (past era) and in 187 patients followed from 1999 to 2001 (current era). Outcomes were compared between these two groups of patients and those who underwent heart transplantation from 1993 to 2000. Survival in the past era was 78% at one year and 67% at two years, as compared with 88% and 79%, respectively, in the current era (both p < 0.01). One-year event-free survival (without urgent transplantation or left ventricular assist device) was improved in the current era, regardless of initial peak VO(2): 64% vs. 48% for peak VO(2) <10 ml/min/kg (p = 0.09), 81% vs. 70% for 10 to 14 ml/min/kg (p = 0.05), and 93% vs. 82% for >14 ml/min/kg (p = 0.04). Of the patients with peak VO(2) of 10 to 14 ml/min/kg, 55% had low-risk HFSS and exhibited 88% one-year event-free survival. One-year survival after transplantation was 88%, which is similar to the 85% rate reported by the United Network for Organ Sharing for 1999 to 2000. Survival for HF patients in the current era has improved significantly, necessitating re-evaluation of the listing criteria for heart transplantation.

On the spreading and instability of gravity current fronts of arbitrary shape

NASA Astrophysics Data System (ADS)

Zgheib, N.; Bonometti, T.; Balachandar, S.

2012-11-01

Experiments, simulations and theoretical analysis were carried out to study the influence of geometry on the spreading of gravity currents. The horizontal spreading of three different intial planforms of initial release were investigated: an extended ellipse, a cross, and a circle. The experiments used a pulley system for a swift nearly instantaneous release. The case of the axisymmetric cylinder compared favorably with earlier simulations. We ran experiments for multiple aspect ratios for all three configurations. Perhaps the most intriguing of the three cases is the ``ellipse,'' which within a short period of release flipped the major and minor axes. This behavior cannot be captured by current theoretical methods (such as the Box Model). These cases have also been investigated using shallow water and direct numerical simulations. Also, in this study, we investigate the possibility of a Rayleigh-Taylor (RT) instability of the radially moving, but decelerating front. We present a simple theoretical framework based on the inviscid Shallow Water Equations. The theoretical results are supplemented and compared to highly resolved three-dimensional simulations with the Boussinesq approximation. Chateaubriand Fellowship - NSF PIRE grant OISE-0968313.

An experimental system for controlled exposure of biological samples to electrostatic discharges.

PubMed

Marjanovič, Igor; Kotnik, Tadej

2013-12-01

Electrostatic discharges occur naturally as lightning strokes, and artificially in light sources and in materials processing. When an electrostatic discharge interacts with living matter, the basic physical effects can be accompanied by biophysical and biochemical phenomena, including cell excitation, electroporation, and electrofusion. To study these phenomena, we developed an experimental system that provides easy sample insertion and removal, protection from airborne particles, observability during the experiment, accurate discharge origin positioning, discharge delivery into the sample either through an electric arc with adjustable air gap width or through direct contact, and reliable electrical insulation where required. We tested the system by assessing irreversible electroporation of Escherichia coli bacteria (15 mm discharge arc, 100 A peak current, 0.1 μs zero-to-peak time, 0.2 μs peak-to-halving time), and gene electrotransfer into CHO cells (7 mm discharge arc, 14 A peak current, 0.5 μs zero-to-peak time, 1.0 μs peak-to-halving time). Exposures to natural lightning stroke can also be studied with this system, as due to radial current dissipation, the conditions achieved by a stroke at a particular distance from its entry are also achieved by an artificial discharge with electric current downscaled in magnitude, but similar in time course, correspondingly closer to its entry. © 2013.

Modeling of marginal burning state of fire spread in live chaparral shrub fuel bed

Treesearch

X. Zhou; S. Mahalingam; D. Weise

2005-01-01

Prescribed burning in chaparral, currently used to manage wildland fuels and reduce wildfire hazard, is often conducted under marginal burning conditions. The relative importance of the fuel and environmental variables that determine fire spread success in chaparral fuels is not quantitatively understood. Based on extensive experimental study, a two-dimensional...

Cassette structures associated with antibiotic resistance genes in Salmonella enterica isolated from processing plants, food animals, and retail meats

USDA-ARS?s Scientific Manuscript database

Slowing the spread of antibiotic resistance (AR) is one of the most urgent tasks currently facing the field of microbiology. Mobile genetic elements, like plasmids and integrons, allow AR genes to transfer horizontally, thus increasing the spread of AR genes. Determining which AR genes are found on ...

METHOD OF PEAK CURRENT MEASUREMENT

DOEpatents

Baker, G.E.

1959-01-20

The measurement and recording of peak electrical currents are described, and a method for utilizing the magnetic field of the current to erase a portion of an alternating constant frequency and amplitude signal from a magnetic mediums such as a magnetic tapes is presented. A portion of the flux from the current carrying conductor is concentrated into a magnetic path of defined area on the tape. After the current has been recorded, the tape is played back. The amplitude of the signal from the portion of the tape immediately adjacent the defined flux area and the amplitude of the signal from the portion of the tape within the area are compared with the amplitude of the signal from an unerased portion of the tape to determine the percentage of signal erasure, and thereby obtain the peak value of currents flowing in the conductor.

Discharge mode transition and temporal-spatial evolution of an air-water plasma jet generated by pulsating DC power

NASA Astrophysics Data System (ADS)

Lei, J.; Geng, Y.; Liu, K.; Zhu, W.; Zheng, Z.; Hu, H.

2017-12-01

In this paper, pulsating direct current air-water plasma jet, which can increase the production of •OH and decrease the temperature, is studied. The results show that the discharge mode changes in one cycle from corona discharge with steep Trichel current pulse to glow-like discharge. It is unknown whether the different discharge modes and water ratio have an effect on the transient process of the excited O and •OH production and the mechanism of plasma propagation. So, a series of experiments are done in this paper. The results show that the changing rules of both the excited state O and the discharge current reach their two peak values synchronously. And its maximum appears at the time of the first peak current value in corona mode. However, the change of the excited state •OH is different. It increases to its maximum at the time of the second peak current value in glow-like mode. Besides, the intensified charge coupled device photographs show that the luminous intensity of the discharge zone at the first peak current value in corona mode is stronger than the second peak current value in glow-like mode. At the same time, the discharge area of the former is larger than the latter. Nevertheless, with the increase in water ratio, the discharge area change reversed. Additionally, the air plasma plume propagation depends on the gas flow. The initial propagation velocity decreases with the increase in water ratio.

Aerobiological monitoring and mapping of Ambrosia plants in the province of Parma (northern Italy, southern Po valley), a useful tool for targeted preventive measures.

PubMed

Albertini, R; Ugolotti, M; Ghillani, L; Adorni, M; Vitali, P; Signorelli, C; Pasquarella, C

2017-01-01

Ambrosia is an annual anemophilous weed producing allergenic pollen affecting public health in European countries. In Italy, the most infested region is Lombardy where, in some areas, it is the major cause of hay fever. In the Parma district, until 2007, Ambrosia seemed to be very rare, despite an observed increase of Seasonal Pollen Index (SPI), of pollen peak value and of asthma among ragweed sensitized patients. The aims of this study were to calculate ragweed pollen season and trends from 1996 to 2015, to assess the relationships between pollen season characteristics and selected meteorological data, to map plants in the territory and to evaluate the presence of beetle Ophraella communa (Ophraella), known as an eater of Ambrosia leaves. The following pollination parameters: start, end, duration, peak concentration date, peak values, SPI and the following climatic parameters: temperature, relative humidity, rainfall, were analyzed. The ragweed plants sites were mapped and the presence of Ophraella was assessed during naturalistic activities. Significant SPI and pollen peak value increase until 2011 were observed, but recently, 2012-2015 vs 2009-2011, a strong reduction (about 50%) of these parameters was observed. The spring average air temperature increased significantly. The results of the correlation analysis showed Ambrosia season characteristics significantly related. We identified the sites source of Ambrosia, even downtown at the confluence between Parma and Baganza rivers. Ophraella was observed for the first time in 2014. The results showed the spread of ragweed plants over the territory and the risk of allergy increase that ragweed could cause. It remains to evaluate the role of the Ophraella in the reduction of Ambrosia pollen concentration. It is important to consider the potential risk Ophraella may represent for sunflower and other taxonomically related crop plants and other native and exotic species. The lack of initiatives by the Health Authorities to prevent and to contrast the spread of Ambrosia in the Parma area could cause public health consequences and an increase in health expenditures.

Rapid hydrothermal cooling above the axial melt lens at fast-spreading mid-ocean ridge

NASA Astrophysics Data System (ADS)

Zhang, Chao; Koepke, Juergen; Kirchner, Clemens; Götze, Niko; Behrens, Harald

2014-09-01

Axial melt lenses sandwiched between the lower oceanic crust and the sheeted dike sequences at fast-spreading mid-ocean ridges are assumed to be the major magma source of oceanic crust accretion. According to the widely discussed ``gabbro glacier'' model, the formation of the lower oceanic crust requires efficient cooling of the axial melt lens, leading to partial crystallization and crystal-melt mush subsiding down to lower crust. These processes are believed to be controlled by periodical magma replenishment and hydrothermal circulation above the melt lens. Here we quantify the cooling rate above melt lens using chemical zoning of plagioclase from hornfelsic recrystallized sheeted dikes drilled from the East Pacific at the Integrated Ocean Drilling Program Hole 1256D. We estimate the cooling rate using a forward modelling approach based on CaAl-NaSi interdiffusion in plagioclase. The results show that cooling from the peak thermal overprint at 1000-1050°C to 600°C are yielded within about 10-30 years as a result of hydrothermal circulation above melt lens during magma starvation. The estimated rapid hydrothermal cooling explains how the effective heat extraction from melt lens is achieved at fast-spreading mid-ocean ridges.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cuevas, F.A.; Curilef, S., E-mail: scurilef@ucn.cl; Plastino, A.R., E-mail: arplastino@ugr.es

The spread of a wave-packet (or its deformation) is a very important topic in quantum mechanics. Understanding this phenomenon is relevant in connection with the study of diverse physical systems. In this paper we apply various 'spreading measures' to characterize the evolution of an initially localized wave-packet in a tight-binding lattice, with special emphasis on information-theoretical measures. We investigate the behavior of both the probability distribution associated with the wave packet and the concomitant probability current. Complexity measures based upon Renyi entropies appear to be particularly good descriptors of the details of the delocalization process. - Highlights: > Spread ofmore » highly localized wave-packet in the tight-binding lattice. > Entropic and information-theoretical characterization is used to understand the delocalization. > The behavior of both the probability distribution and the concomitant probability current is investigated. > Renyi entropies appear to be good descriptors of the details of the delocalization process.« less

Reducing Current Spread using Current Focusing in Cochlear Implant Users

PubMed Central

Landsberger, David M.; Padilla, Monica; Srinivasan, Arthi G.

2012-01-01

Cochlear implant performance in difficult listening situations is limited by channel interactions. It is known that partial tripolar (PTP) stimulation reduces the spread of excitation (SOE). However, the greater the degree of current focusing, the greater the absolute current required to maintain a fixed loudness. As current increases, so does SOE. In experiment 1, the SOE for equally loud stimuli with different degrees of current focusing is measured via a forward-masking procedure. Results suggest that at a fixed loudness, some but not all patients have a reduced SOE with PTP stimulation. Therefore, it seems likely that a PTP speech processing strategy could improve spectral resolution for only those patients with a reduced SOE. In experiment 2, the ability to discriminate different levels of current focusing was measured. In experiment 3, patients subjectively scaled verbal descriptors of stimuli of various levels of current focusing. Both discrimination and scaling of verbal descriptors correlated well with SOE reduction, suggesting that either technique have the potential to be used clinically to quickly predict which patients would receive benefit from a current focusing strategy. PMID:22230370

Fractionation of unreduced gluten proteins on SEC and their relationship with cookie quality characteristics.

PubMed

Chaudhary, Nisha; Dangi, Priya; Khatkar, B S

2017-02-01

The size distribution assessment of unreduced wheat gluten proteins of commercial Indian wheat varieties was examined using Size-Exclusion Fast Protein Liquid Chromatography. Elution profiles were fractionated into five peaks, with the molecular weights of eluting peaks as 130-30, 55-20, 28-10 and <10 kDa (IV and V), respectively. Peak I (glutenins) and II (gliadins) exhibited contrary results with AWRC (r = 0.928** and r = -0.831**), R/E ratio (r = 0.745** and r = -0.869**), gluten index (r = 0.959** and r = -0.994**), gliadin/glutenin ratio (r = -0.952** and r = 0.948**), dough development time (r = 0.830** and r = -0.930**), dough stability (r = 0.901** and r = -0.979**) and dough weakening (r = -0.969** and r = 0.986**). Significant statistical correlation was also observed for peak I and II with cookie hardness (r = 0.948** and r = -0.924**) and cookie spread (r = -0.837** and r = -0.743**) respectively. Peak III, IV and V occupied a minor fraction of whole and did not exhibit a statistically significant correlation with any of the quality parameters.

A novel epidemic spreading model with decreasing infection rate based on infection times

NASA Astrophysics Data System (ADS)

Huang, Yunhan; Ding, Li; Feng, Yun

2016-02-01

A new epidemic spreading model where individuals can be infected repeatedly is proposed in this paper. The infection rate decreases according to the times it has been infected before. This phenomenon may be caused by immunity or heightened alertness of individuals. We introduce a new parameter called decay factor to evaluate the decrease of infection rate. Our model bridges the Susceptible-Infected-Susceptible(SIS) model and the Susceptible-Infected-Recovered(SIR) model by this parameter. The proposed model has been studied by Monte-Carlo numerical simulation. It is found that initial infection rate has greater impact on peak value comparing with decay factor. The effect of decay factor on final density and threshold of outbreak is dominant but weakens significantly when considering birth and death rates. Besides, simulation results show that the influence of birth and death rates on final density is non-monotonic in some circumstances.

Efficient monoenergetic proton beam from ultra-fast laser interaction with nanostructured targets

NASA Astrophysics Data System (ADS)

Fazeli, R.

2018-03-01

The broad energy spectrum of laser-accelerated proton beams is the most important difficulty associated with such particle sources on the way to future applications such as medical therapy, proton imaging, inertial fusion, and high-energy physics. The generation of proton beams with enhanced monoenergetic features through an ultra-intense laser interaction with optimized nanostructured targets is reported. Targets were irradiated by 40 fs laser pulses of intensity 5.5 ×1020 W c m -2 and wavelength 1 μm. The results of multi-parametric Particle-in-Cell calculations showed that proton beams with considerably reduced energy spread can be obtained by using the proposed nanostructured target. At optimized target dimensions, the proton spectrum was found to exhibit a narrow peak at about 63 MeV with a relative energy spread of ΔE /Epeak˜ 5 % which is efficiently lower than what is expected for unstructured double layer targets (˜70%).

First Point-Spread Function and X-Ray Phase Contrast Imaging Results with an 88-mm Diameter Single Crystal

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lumpkin, A. H.; Garson, A. B.; Anastasio, M. A.

In this study, we report initial demonstrations of the use of single crystals in indirect x-ray imaging with a benchtop implementation of propagation-based (PB) x-ray phase contrast imaging. Based on single Gaussian peak fits to the x-ray images, we observed a four times smaller system point-spread function (PSF) with the 50-μm thick single crystal scintillators than with the reference polycrystalline phosphor/scintillator. Fiber-optic plate depth-of-focus and Al reflective-coating aspects are also elucidated. Guided by the results from the 25-mm diameter crystal samples, we report additionally the first results with a unique 88-mm diameter single crystal bonded to a fiber optic platemore » and coupled to the large format CCD. Both PSF and x-ray phase contrast imaging data are quantified and presented.« less

Golay sequences coded coherent optical OFDM for long-haul transmission

NASA Astrophysics Data System (ADS)

Qin, Cui; Ma, Xiangrong; Hua, Tao; Zhao, Jing; Yu, Huilong; Zhang, Jian

2017-09-01

We propose to use binary Golay sequences in coherent optical orthogonal frequency division multiplexing (CO-OFDM) to improve the long-haul transmission performance. The Golay sequences are generated by binary Reed-Muller codes, which have low peak-to-average power ratio and certain error correction capability. A low-complexity decoding algorithm for the Golay sequences is then proposed to recover the signal. Under same spectral efficiency, the QPSK modulated OFDM with binary Golay sequences coding with and without discrete Fourier transform (DFT) spreading (DFTS-QPSK-GOFDM and QPSK-GOFDM) are compared with the normal BPSK modulated OFDM with and without DFT spreading (DFTS-BPSK-OFDM and BPSK-OFDM) after long-haul transmission. At a 7% forward error correction code threshold (Q2 factor of 8.5 dB), it is shown that DFTS-QPSK-GOFDM outperforms DFTS-BPSK-OFDM by extending the transmission distance by 29% and 18%, in non-dispersion managed and dispersion managed links, respectively.

A study of ground motion attenuation in the Southern Great Basin, Nevada-California, using several techniques for estimates of Qs , log A 0, and coda Q

NASA Astrophysics Data System (ADS)

Rogers, A. M.; Harmsen, S. C.; Herrmann, R. B.; Meremonte, M. E.

1987-04-01

As a first step in the assessment of the earthquake hazard in the southern Great Basin of Nevada-California, this study evaluates the attenuation of peak vertical ground motions using a number of different regression models applied to unfiltered and band-pass-filtered ground motion data. These data are concentrated in the distance range 10-250 km. The regression models include parameters to account for geometric spreading, anelastic attenuation with a power law frequency dependence, source size, and station site effects. We find that the data are most consistent with an essentially frequency-independent Q and a geometric spreading coefficient less than 1.0. Regressions are also performed on vertical component peak amplitudes reexpressed as pseudo-Wood-Anderson peak amplitude estimates (PWA), permitting comparison with earlier work that used Wood-Anderson (WA) data from California. Both of these results show that Q values in this region are high relative to California, having values in the range 700-900 over the frequency band 1-10 Hz. Comparison of ML magnitudes from stations BRK and PAS for earthquakes in the southern Great Basin shows that these two stations report magnitudes with differences that are distance dependent. This bias suggests that the Richter log A0 curve appropriate to California is too steep for earthquakes occurring in southern Nevada, a result implicitly supporting our finding that Q values are higher than those in California. The PWA attenuation functions derived from our data also indicate that local magnitudes reported by California observatories for earthquakes in this region may be overestimated by as much as 0.8 magnitude units in some cases. Both of these results will have an effect on the assessment of the earthquake hazard in this region. The robustness of our regression technique to extract the correct geometric spreading coefficient n and anelastic attenuation Q is tested by applying the technique to simulated data computed with given n and Q values. Using a stochastic modeling technique, we generate suites of seismograms for the distance range 10-200 km and for both WA and short-period vertical component seismometers. Regressions on the peak amplitudes from these records show that our regression model extracts values of n and Q approximately equal to the input values for either low-Q California attenuation or high-Q southern Nevada attenuation. Regressions on stochastically modeled WA and PWA amplitudes also provides a method of evaluating differences in magnitudes from WA and PWA amplitudes due to recording instrument response characteristics alone. These results indicate a difference between MLWA and MLPWA equal to 0.15 magnitude units, which we term the residual instrument correction. In contrast to the peak amplitude results, coda Q determinations using the single scatterer theory indicate that Qc values are dependent on source type and are proportional to ƒp, where p = 0.8 to 1.0. This result suggests that a difference exists between attenuation mechanisms for direct waves and backscattered waves in this region.

Fire safety in space - Investigating flame spread interaction over wires

NASA Astrophysics Data System (ADS)

Citerne, Jean-Marie; Dutilleul, Hugo; Kizawa, Koki; Nagachi, Masashi; Fujita, Osamu; Kikuchi, Masao; Jomaas, Grunde; Rouvreau, Sébastien; Torero, Jose L.; Legros, Guillaume

2016-09-01

A new rig for microgravity experiments was used for the study flame spread of parallel polyethylene-coated wires in concurrent and opposed airflow. The parabolic flight experiments were conducted at small length- and time scales, i.e. typically over 10 cm long samples for up to 20 s. For the first time, the influence of neighboring spread on the mass burning rate was assessed in microgravity. The observations are contrasted with the influence characterized in normal gravity. The experimental results are expected to deliver meaningful guidelines for future, planned experiments at a larger scale. Arising from the current results, the issue of the potential interaction among spreading flames also needs to be carefully investigated as this interaction plays a major role in realistic fire scenarios, and therefore on the design of the strategies that would allow the control of such a fire. Once buoyancy has been removed, the characteristic length and time scales of the different modes of heat and mass transfer are modified. For this reason, interaction among spreading flames may be revealed in microgravity, while it would not at normal gravity, or vice versa. Furthermore, the interaction may lead to an enhanced spread rate when mutual preheating dominates or, conversely, a reduced spread rate when oxidizer flow vitiation is predominant. In more general terms, the current study supports both the SAFFIRE and the FLARE projects, which are large projects with international scientific teams. First, material samples will be tested in a series of flight experiments (SAFFIRE 1-3) conducted in Cygnus vehicles after they have undocked from the ISS. These experiments will allow the study of ignition and possible flame spread in real spacecraft conditions, i.e. over real length scale samples within real time scales. Second, concomitant research conducted within the FLARE project is dedicated to the assessment of new standard tests for materials that a spacecraft can be composed of. Finally, these tests aim to define the ambient conditions that will mitigate and potentially prohibit the flame spread in microgravity over the material studied.

Breath Powered Nasal Delivery: A New Route to Rapid Headache Relief

PubMed Central

Djupesland, Per G; Messina, John C; Mahmoud, Ramy A

2013-01-01

The nose offers an attractive noninvasive alternative for drug delivery. Nasal anatomy, with a large mucosal surface area and high vascularity, allows for rapid systemic absorption and other potential benefits. However, the complex nasal geometry, including the narrow anterior valve, poses a serious challenge to efficient drug delivery. This barrier, plus the inherent limitations of traditional nasal delivery mechanisms, has precluded achievement of the full potential of nasal delivery. Breath Powered bi-directional delivery, a simple but novel nasal delivery mechanism, overcomes these barriers. This innovative mechanism has now been applied to the delivery of sumatriptan. Multiple studies of drug deposition, including comparisons of traditional nasal sprays to Breath Powered delivery, demonstrate significantly improved deposition to superior and posterior intranasal target sites beyond the nasal valve. Pharmacokinetic studies in both healthy subjects and migraineurs suggest that improved deposition of sumatriptan translates into improved absorption and pharmacokinetics. Importantly, the absorption profile is shifted toward a more pronounced early peak, representing nasal absorption, with a reduced late peak, representing predominantly gastrointestinal (GI) absorption. The flattening and “spreading out” of the GI peak appears more pronounced in migraine sufferers than healthy volunteers, likely reflecting impaired GI absorption described in migraineurs. In replicated clinical trials, Breath Powered delivery of low-dose sumatriptan was well accepted and well tolerated by patients, and onset of pain relief was faster than generally reported in previous trials with noninjectable triptans. Interestingly, Breath Powered delivery also allows for the potential of headache-targeted medications to be better delivered to the trigeminal nerve and the sphenopalatine ganglion, potentially improving treatment of various types of headache. In brief, Breath Powered bi-directional intranasal delivery offers a new and more efficient mechanism for nasal drug delivery, providing an attractive option for improved treatment of headaches by enabling or enhancing the benefits of current and future headache therapies. PMID:24024605

SU-D-BRCD-06: Measurement of Elekta Electron Energy Spectra Using a Small Magnetic Spectrometer.

PubMed

Hogstrom, K; McLaughlin, D; Gibbons, J; Shikhaliev, P; Clarke, T; Henderson, A; Taylor, D; Shagin, P; Liang, E

2012-06-01

To demonstrate how a small magnetic spectrometer can measure the energy spectra of seven electron beams on an Elekta Infinity tuned to match beams on a previously commissioned machine. Energyspectra were determined from measurements of intensity profiles on 6″-long computed radiographic (CR) strips after deflecting a narrow incident beam using a small (28 lbs.), permanent magnetic spectrometer. CR plateexposures (<1cGy) required special beam reduction techniques and bremsstrahlung shielding. Curves of CR intensity (corrected for non- linearity and background) versus position were transformed into energy spectra using the transformation from position (x) on the CR plate to energy (E) based on the Lorentz force law. The effective magnetic field and its effective edge, parameters in the transformation, were obtained by fitting a plot of most probable incident energy (determined from practical range) to the peak position. The calibration curve (E vs. x) fit gave 0.423 Tesla for the effective magnetic field. Most resulting energy spectra were characterized by a single, asymmetric peak with peak position and FWHM increasing monotonically with beam energy. Only the 9-MeV spectrum was atypical, possibly indicating suboptimal beam tuning. These results compared well with energy spectra independently determined by adjusting each spectrum until the EGSnrc Monte Carlo calculated percent depth-dose curve agreed well with the corresponding measured curve. Results indicate that this spectrometer and methodology could be useful for measuring energy spectra of clinical electron beams at isocenter. Future work will (1) remove the small effect of the detector response function (due to pinhole size and incident angular spread) from the energy spectra, (2) extract the energy spectra exiting the accelerator from current results, (3) use the spectrometer to compare energy spectra of matched beams among our clinical sites, and (4) modify the spectrometer to utilize radiochromic film. © 2012 American Association of Physicists in Medicine.

Epidemic spreading on random surfer networks with infected avoidance strategy

NASA Astrophysics Data System (ADS)

Feng, Yun; Ding, Li; Huang, Yun-Han; Guan, Zhi-Hong

2016-12-01

In this paper, we study epidemic spreading on random surfer networks with infected avoidance (IA) strategy. In particular, we consider that susceptible individuals’ moving direction angles are affected by the current location information received from infected individuals through a directed information network. The model is mainly analyzed by discrete-time numerical simulations. The results indicate that the IA strategy can restrain epidemic spreading effectively. However, when long-distance jumps of individuals exist, the IA strategy’s effectiveness on restraining epidemic spreading is heavily reduced. Finally, it is found that the influence of the noises from information transferring process on epidemic spreading is indistinctive. Project supported in part by the National Natural Science Foundation of China (Grant Nos. 61403284, 61272114, 61673303, and 61672112) and the Marine Renewable Energy Special Fund Project of the State Oceanic Administration of China (Grant No. GHME2013JS01).

Gambling and the Law(®): Endless fields of dreams.

PubMed

Rose, I N

1995-03-01

This article examines the current trends of proliferation of commercial gaming, especially in the United States, in the context of the "third wave" of legalization of gambling that has been experienced since the founding of the nation. The author looks at the historic foundations of the spread of casino-style gambling, and notes the types of casino gaming that have led the way in the current expansion. He also points out why it is reasonable to expect that this wave too may come crashing down, as general acceptance of wide-spread casino gaming in America may indeed be short-lived.

Modeling the release, spreading, and burning of LNG, LPG, and gasoline on water.

PubMed

Johnson, David W; Cornwell, John B

2007-02-20

Current interest in the shipment of liquefied natural gas (LNG) has renewed the debate about the safety of shipping large volumes of flammable fuels. The size of a spreading pool following a release of LNG from an LNG tank ship has been the subject of numerous papers and studies dating back to the mid-1970s. Several papers have presented idealized views of how the LNG would be released and spread across a quiescent water surface. There is a considerable amount of publicly available material describing these idealized releases, but little discussion of how other flammable fuels would behave if released from similar sized ships. The purpose of this paper is to determine whether the models currently available from the United States Federal Energy Regulatory Commission (FERC) can be used to simulate the release, spreading, vaporization, and pool fire impacts for materials other than LNG, and if so, identify which material-specific parameters are required. The review of the basic equations and principles in FERC's LNG release, spreading, and burning models did not reveal a critical fault that would prevent their use in evaluating the consequences of other flammable fluid releases. With the correct physical data, the models can be used with the same level of confidence for materials such as LPG and gasoline as they are for LNG.

Transcranial electrical stimulation over visual cortex evokes phosphenes with a retinal origin.

PubMed

Kar, Kohitij; Krekelberg, Bart

2012-10-01

Transcranial electrical stimulation (tES) is a promising therapeutic tool for a range of neurological diseases. Understanding how the small currents used in tES spread across the scalp and penetrate the brain will be important for the rational design of tES therapies. Alternating currents applied transcranially above visual cortex induce the perception of flashes of light (phosphenes). This makes the visual system a useful model to study tES. One hypothesis is that tES generates phosphenes by direct stimulation of the cortex underneath the transcranial electrode. Here, we provide evidence for the alternative hypothesis that phosphenes are generated in the retina by current spread from the occipital electrode. Building on the existing literature, we first confirm that phosphenes are induced at lower currents when electrodes are placed farther away from visual cortex and closer to the eye. Second, we explain the temporal frequency tuning of phosphenes based on the well-known response properties of primate retinal ganglion cells. Third, we show that there is no difference in the time it takes to evoke phosphenes in the retina or by stimulation above visual cortex. Together, these findings suggest that phosphenes induced by tES over visual cortex originate in the retina. From this, we infer that tES currents spread well beyond the area of stimulation and are unlikely to lead to focal neural activation. Novel stimulation protocols that optimize current distributions are needed to overcome these limitations of tES.

Helium ions at the heidelberg ion beam therapy center: comparisons between FLUKA Monte Carlo code predictions and dosimetric measurements

NASA Astrophysics Data System (ADS)

Tessonnier, T.; Mairani, A.; Brons, S.; Sala, P.; Cerutti, F.; Ferrari, A.; Haberer, T.; Debus, J.; Parodi, K.

2017-08-01

In the field of particle therapy helium ion beams could offer an alternative for radiotherapy treatments, owing to their interesting physical and biological properties intermediate between protons and carbon ions. We present in this work the comparisons and validations of the Monte Carlo FLUKA code against in-depth dosimetric measurements acquired at the Heidelberg Ion Beam Therapy Center (HIT). Depth dose distributions in water with and without ripple filter, lateral profiles at different depths in water and a spread-out Bragg peak were investigated. After experimentally-driven tuning of the less known initial beam characteristics in vacuum (beam lateral size and momentum spread) and simulation parameters (water ionization potential), comparisons of depth dose distributions were performed between simulations and measurements, which showed overall good agreement with range differences below 0.1 mm and dose-weighted average dose-differences below 2.3% throughout the entire energy range. Comparisons of lateral dose profiles showed differences in full-width-half-maximum lower than 0.7 mm. Measurements of the spread-out Bragg peak indicated differences with simulations below 1% in the high dose regions and 3% in all other regions, with a range difference less than 0.5 mm. Despite the promising results, some discrepancies between simulations and measurements were observed, particularly at high energies. These differences were attributed to an underestimation of dose contributions from secondary particles at large angles, as seen in a triple Gaussian parametrization of the lateral profiles along the depth. However, the results allowed us to validate FLUKA simulations against measurements, confirming its suitability for 4He ion beam modeling in preparation of clinical establishment at HIT. Future activities building on this work will include treatment plan comparisons using validated biological models between proton and helium ions, either within a Monte Carlo treatment planning engine based on the same FLUKA code, or an independent analytical planning system fed with a validated database of inputs calculated with FLUKA.

Helium ions at the heidelberg ion beam therapy center: comparisons between FLUKA Monte Carlo code predictions and dosimetric measurements.

PubMed

Tessonnier, T; Mairani, A; Brons, S; Sala, P; Cerutti, F; Ferrari, A; Haberer, T; Debus, J; Parodi, K

2017-08-01

In the field of particle therapy helium ion beams could offer an alternative for radiotherapy treatments, owing to their interesting physical and biological properties intermediate between protons and carbon ions. We present in this work the comparisons and validations of the Monte Carlo FLUKA code against in-depth dosimetric measurements acquired at the Heidelberg Ion Beam Therapy Center (HIT). Depth dose distributions in water with and without ripple filter, lateral profiles at different depths in water and a spread-out Bragg peak were investigated. After experimentally-driven tuning of the less known initial beam characteristics in vacuum (beam lateral size and momentum spread) and simulation parameters (water ionization potential), comparisons of depth dose distributions were performed between simulations and measurements, which showed overall good agreement with range differences below 0.1 mm and dose-weighted average dose-differences below 2.3% throughout the entire energy range. Comparisons of lateral dose profiles showed differences in full-width-half-maximum lower than 0.7 mm. Measurements of the spread-out Bragg peak indicated differences with simulations below 1% in the high dose regions and 3% in all other regions, with a range difference less than 0.5 mm. Despite the promising results, some discrepancies between simulations and measurements were observed, particularly at high energies. These differences were attributed to an underestimation of dose contributions from secondary particles at large angles, as seen in a triple Gaussian parametrization of the lateral profiles along the depth. However, the results allowed us to validate FLUKA simulations against measurements, confirming its suitability for 4 He ion beam modeling in preparation of clinical establishment at HIT. Future activities building on this work will include treatment plan comparisons using validated biological models between proton and helium ions, either within a Monte Carlo treatment planning engine based on the same FLUKA code, or an independent analytical planning system fed with a validated database of inputs calculated with FLUKA.

Hurricanes accelerated the Florida-Bahamas lionfish invasion.

PubMed

Johnston, Matthew W; Purkis, Sam J

2015-06-01

In this study, we demonstrate how perturbations to the Florida Current caused by hurricanes are relevant to the spread of invasive lionfish from Florida to the Bahamas. Without such perturbations, this current represents a potential barrier to the transport of planktonic lionfish eggs and larvae across the Straits of Florida. We further show that once lionfish became established in the Bahamas, hurricanes significantly hastened their spread through the island chain. We gain these insights through: (1) an analysis of the direction and velocity of simulated ocean currents during the passage of hurricanes through the Florida Straits and (2) the development of a biophysical model that incorporates the tolerances of lionfish to ocean climate, their reproductive strategy, and duration that the larvae remain viable in the water column. On the basis of this work, we identify 23 occasions between the years 1992 and 2006 in which lionfish were provided the opportunity to breach the Florida Current. We also find that hurricanes during this period increased the rate of spread of lionfish through the Bahamas by more than 45% and magnified its population by at least 15%. Beyond invasive lionfish, we suggest that extreme weather events such as hurricanes likely help to homogenize the gene pool for all Caribbean marine species susceptible to transport. © 2015 John Wiley & Sons Ltd.

Dependence of electron peak current on hollow cathode dimensions and seed electron energy in a pseudospark discharge

NASA Astrophysics Data System (ADS)

Cetiner, S. O.; Stoltz, P.; Messmer, P.; Cambier, J.-L.

2008-01-01

The prebreakdown and breakdown phases of a pseudospark discharge are investigated using the two-dimensional kinetic plasma simulation code OOPIC™ PRO. Trends in the peak electron current at the anode are presented as function of the hollow cathode dimensions and mean seed injection velocities at the cavity back wall. The plasma generation process by ionizing collisions is examined, showing the effect on supplying the electrons that determine the density of the beam. The mean seed velocities used here are varied between the velocity corresponding to the energy of peak ionization cross section, 15 times this value and no mean velocity (i.e., electrons injected with a temperature of 2.5eV). The reliance of the discharge characteristics on the penetrating electric field is shown to decrease as the mean seed injection velocity increases because of its ability to generate a surplus plasma independent of the virtual anode. As a result, the peak current increases with the hollow cathode dimensions for the largest average injection velocity, while for the smallest value it increases with the area of penetration of the electric field in the hollow cathode interior. Additionally, for a given geometry an increase in the peak current with the surplus plasma generated is observed. For the largest seed injection velocity used a dependence of the magnitude of the peak current on the ratio of the hole thickness and hollow cathode depth to the hole height is demonstrated. This means similar trends of the peak current are generated when the geometry is resized. Although the present study uses argon only, the variation in the discharge dependencies with the seed injection energy relative to the ionization threshold is expected to apply independently of the gas type. Secondary electrons due to electron and ion impact are shown to be important only for the largest impact areas and discharge development times of the study.

Bounds on the cross-correlation functions of state m-sequences

NASA Astrophysics Data System (ADS)

Woodcock, C. F.; Davies, Phillip A.; Shaar, Ahmed A.

1987-03-01

Lower and upper bounds on the peaks of the periodic Hamming cross-correlation function for state m-sequences, which are often used in frequency-hopped spread-spectrum systems, are derived. The state position mapped (SPM) sequences of the state m-sequences are described. The use of SPM sequences for OR-channel code division multiplexing is studied. The relation between the Hamming cross-correlation function and the correlation function of SPM sequence is examined. Numerical results which support the theoretical data are presented.

Plasma-Filled Rod-Pinch Diode Research on Gamble II

DTIC Science & Technology

2007-06-01

by the dashed red line in Fig. 3. CaF2 thermoluminescent dosimeters ( TLDs ) located on the front surface of the rolled edge measure the dose. The...half-maximum line-spread function] and high dose [23 rad(CaF2) at 1 m] with 1-2 MeV electron energies are unique capabilities that the PFRP offers...for radiographic imaging in this electron -energy range. The source distribution has a narrow central peak that can enhance the spatial resolution

Effect of the Internet Commerce on Dispersal Modes of Invasive Alien Species

PubMed Central

Lenda, Magdalena; Skórka, Piotr; Knops, Johannes M. H.; Moroń, Dawid; Sutherland, William J.; Kuszewska, Karolina; Woyciechowski, Michał

2014-01-01

The spread of invasive alien plants has considerable environmental and economic consequences, and is one of the most challenging ecological problems. The spread of invasive alien plant species depends largely on long-distance dispersal, which is typically linked with human activity. The increasing domination of the internet will have impacts upon almost all components of our lives, including potential consequences for the spread of invasive species. To determine whether the rise of Internet commerce has any consequences for the spread of invasive alien plant species, we studied the sale of thirteen of some of the most harmful Europe invasive alien plant species sold as decorative plants from twenty-eight large, well known gardening shops in Poland that sold both via the Internet and through traditional customer sales. We also analyzed temporal changes in the number of invasive plants sold in the largest Polish internet auction portal. When sold through the Internet invasive alien plant species were transported considerably longer distances than for traditional sales. For internet sales, seeds of invasive alien plant species were transported further than were live plants saplings; this was not the case for traditional sales. Also, with e-commerce the shape of distance distribution were flattened with low skewness comparing with traditional sale where the distributions were peaked and right-skewed. Thus, e-commerce created novel modes of long-distance dispersal, while traditional sale resembled more natural dispersal modes. Moreover, analysis of sale in the biggest Polish internet auction portal showed that the number of alien specimens sold via the internet has increased markedly over recent years. Therefore internet commerce is likely to increase the rate at which ecological communities become homogenized and increase spread of invasive species by increasing the rate of long distance dispersal. PMID:24932498

Rapid spread and association of Schmallenberg virus with ruminant abortions and foetal death in Austria in 2012/2013.

PubMed

Steinrigl, Adolf; Schiefer, Peter; Schleicher, Corina; Peinhopf, Walter; Wodak, Eveline; Bagó, Zoltán; Schmoll, Friedrich

2014-10-15

Schmallenberg virus (SBV) has emerged in summer-autumn 2011 in north-western Europe. Since then, SBV has been continuously spreading over Europe, including Austria, where antibodies to SBV, as well as SBV genome, were first detected in autumn 2012. This study was performed to demonstrate the dynamics of SBV spread within Austria, after its probable first introduction in summer 2012. True seroprevalence estimates for cattle and small ruminates were calculated to demonstrate temporal and regional differences of infection. Furthermore, the probability of SBV genome detection in foetal tissues of aborted or stillborn cattle and small ruminants as well as in allantoic fluid samples from cows with early foetal losses was retrospectively assessed. SBV first reached Austria most likely in July-August 2012, as indicated by retrospective detection of SBV antibodies and SBV genome in archived samples. From August to October 2012, a rapid increase in seroprevalence to over 98% in cattle and a contemporaneous peak in the detection of SBV genome in foetal tissues and allantoic fluid samples was noted, indicating widespread acute infections. Notably, foetal malformations were absent in RT-qPCR positive foetuses at this time of the epidemic. SBV spread within Austrian cattle reached a plateau phase as early as October 2012, without significant regional differences in SBV seroprevalence (98.4-100%). Estimated true seroprevalences among small ruminates were comparatively lower than in cattle and regionally different (58.3-95.6% in October 2012), potentially indicating an eastward spread of the infection, as well as different infection dynamics between cattle and small ruminants. Additionally, the probability of SBV genome detection over time differed significantly between small ruminant and cattle samples subjected to RT-qPCR testing. Copyright © 2014 Elsevier B.V. All rights reserved.

Effect of the internet commerce on dispersal modes of invasive alien species.

PubMed

Lenda, Magdalena; Skórka, Piotr; Knops, Johannes M H; Moroń, Dawid; Sutherland, William J; Kuszewska, Karolina; Woyciechowski, Michał

2014-01-01

The spread of invasive alien plants has considerable environmental and economic consequences, and is one of the most challenging ecological problems. The spread of invasive alien plant species depends largely on long-distance dispersal, which is typically linked with human activity. The increasing domination of the internet will have impacts upon almost all components of our lives, including potential consequences for the spread of invasive species. To determine whether the rise of Internet commerce has any consequences for the spread of invasive alien plant species, we studied the sale of thirteen of some of the most harmful Europe invasive alien plant species sold as decorative plants from twenty-eight large, well known gardening shops in Poland that sold both via the Internet and through traditional customer sales. We also analyzed temporal changes in the number of invasive plants sold in the largest Polish internet auction portal. When sold through the Internet invasive alien plant species were transported considerably longer distances than for traditional sales. For internet sales, seeds of invasive alien plant species were transported further than were live plants saplings; this was not the case for traditional sales. Also, with e-commerce the shape of distance distribution were flattened with low skewness comparing with traditional sale where the distributions were peaked and right-skewed. Thus, e-commerce created novel modes of long-distance dispersal, while traditional sale resembled more natural dispersal modes. Moreover, analysis of sale in the biggest Polish internet auction portal showed that the number of alien specimens sold via the internet has increased markedly over recent years. Therefore internet commerce is likely to increase the rate at which ecological communities become homogenized and increase spread of invasive species by increasing the rate of long distance dispersal.

Early Spatial and Temporal Events of Human T-Lymphotropic Virus Type 1 Spread following Blood-Borne Transmission in a Rabbit Model of Infection ▿

PubMed Central

Haynes, Rashade A. H.; Zimmerman, Bevin; Millward, Laurie; Ware, Evan; Premanandan, Christopher; Yu, Lianbo; Phipps, Andrew J.; Lairmore, Michael D.

2010-01-01

Human T-lymphotropic virus type 1 (HTLV-1) infection causes adult T-cell leukemia/lymphoma (ATL) and is associated with a variety of lymphocyte-mediated disorders. HTLV-1 transmission occurs by transmission of infected cells via breast-feeding by infected mothers, sexual intercourse, and contaminated blood products. The route of exposure and early virus replication events are believed to be key determinants of virus-associated spread, antiviral immune responses, and ultimately disease outcomes. The lack of knowledge of early events of HTLV-1 spread following blood-borne transmission of the virus in vivo hinders a more complete understanding of the immunopathogenesis of HTLV-1 infections. Herein, we have used an established animal model of HTLV-1 infection to study early spatial and temporal events of the viral infection. Twelve-week-old rabbits were injected intravenously with cell-associated HTLV-1 (ACH-transformed R49). Blood and tissues were collected at defined intervals throughout the study to test the early spread of the infection. Antibody and hematologic responses were monitored throughout the infection. HTLV-1 intracellular Tax and soluble p19 matrix were tested from ex vivo cultured lymphocytes. Proviral copy numbers were measured by real-time PCR from blood and tissue mononuclear leukocytes. Our data indicate that intravenous infection with cell-associated HTLV-1 targets lymphocytes located in both primary lymphoid and gut-associated lymphoid compartments. A transient lymphocytosis that correlated with peak virus detection parameters was observed by 1 week postinfection before returning to baseline levels. Our data support emerging evidence that HTLV-1 promotes lymphocyte proliferation preceding early viral spread in lymphoid compartments to establish and maintain persistent infection. PMID:20219918

A Pilot Study Measuring the Distribution and Permeability of a Vaginal HIV Microbicide Gel Vehicle Using Magnetic Resonance Imaging, Single Photon Emission Computed Tomography/Computed Tomography, and a Radiolabeled Small Molecule.

PubMed

Fuchs, Edward J; Schwartz, Jill L; Friend, David R; Coleman, Jenell S; Hendrix, Craig W

2015-11-01

Vaginal microbicide gels containing tenofovir have proven effective in HIV prevention, offering the advantage of reduced systemic toxicity. We studied the vaginal distribution and effect on mucosal permeability of a gel vehicle. Six premenopausal women were enrolled. In Phase 1, a spreading gel containing (99m)technetium-DTPA ((99m)Tc) radiolabel and gadolinium contrast for magnetic resonance imaging (MRI) was dosed intravaginally. MRI was obtained at 0.5, 4, and 24 h, and single photon emission computed tomography with conventional computed tomography (SPECT/CT) at 1.5, 5, and 25 h postdosing. Pads and tissues were measured for activity to determine gel loss. In Phase 2, nonoxynol-9 (N-9), containing (99m)Tc-DTPA, was dosed as a permeability control; permeability was measured in blood and urine for both phases. SPECT/CT showed the distribution of spreading gel throughout the vagina with the highest concentration of radiosignal in the fornices and ectocervix; signal intensity diminished over 25 h. MRI showed the greatest signal accumulation in the fornices, most notably 1-4 h postdosing. The median (interquartile range) isotope signal loss from the vagina through 6 h was 29.1% (15.8-39.9%). Mucosal permeability to (99m)Tc-DTPA following spreading gel was negligible, in contrast to N-9, with detectable radiosignal in plasma, peaking at 8 h (5-12). Following spreading gel dosing, 0.004% (0.001-2.04%) of the radiosignal accumulated in urine over 12 h compared to 8.31% (7.07-11.01%) with N-9, (p=0.043). Spreading gel distributed variably throughout the vagina, persisting for 24 h, with signal concentrating in the fornices and ectocervix. The spreading gel had no significant effect on vaginal mucosal permeability.

Molecular detection of Phytophthora ramorum by real-time PCR using Taqman, SYBR Green and molecular beacons with three genes

Treesearch

G.J. Bilodeau; C.A. Lévesque; A.W.A.M. De Cock; C. Duchaine; G. Kristjansson; R.C. Hamelin

2006-01-01

Sudden oak death, caused by Phytophthora ramorum, is a severe disease that can affect numerous species of trees and shrubs. This pathogen has been spread via nursery stock, and quarantine measures are currently in place to prevent further spread. Molecular assays have been developed to rapidly detect and identify P. ramorum, but...

New insights into the origin of ladder dikes: Implications for punctuated growth and crystal accumulation in the Cathedral Peak granodiorite

NASA Astrophysics Data System (ADS)

Wiebe, R. A.; Jellinek, A. M.; Hodge, K. F.

2017-04-01

Ladder dikes are steep tabular bodies, typically a meter or less thick, composed of moderately dipping, concave upward, alternating dark (i.e. schlieren) and light bands oriented roughly perpendicular to the ladder dike margins. These structures occur widely but sparsely in granitic rocks and are found prominently in the Cathedral Peak granodiorite (CPG) of the Tuolumne Intrusive suite. Previous studies have interpreted that ladder dikes form as a result of processes including the downward flow of crystal mush in cracks within strong crystal mush or by upward flow in steep tubes that migrate within a strong crystal mush. Our new observations indicate that ladder dikes formed by downward flow of crystal mush in troughs or valleys, in a manner potentially comparable to trough bands in mafic layered intrusions. Extensions of the schlieren outward and upward away from the ladder dike margins into the host granite demonstrate that the host granite was deposited as mounds on both sides at the same time as the ladder dikes. Ladder dikes, therefore, record lateral flows of crystal mush on a magma chamber floor. Vertical exposures suggest these flows are on the order of ten meters thick. Some steep exposures on granite domes indicate multiple ladder dikes (and flows) over a stratigraphic height of 80-100 m. Later (stratigraphically higher) flows commonly deform and erode the top of an earlier flow, and granitic material rich in K-feldspar megacrysts has locally engulfed large blocks of ladder dikes, demonstrating that the megacrysts were also transported in flows. Flows in the CPG are directed away from the center of the pluton toward the western and eastern margins and apparently spread along a strong crystal mush floor and into a rheologically complex CPG magma. Whereas established dynamical models for spreading (single phase) gravity currents with simple and complex rheologies explain the elongate geometry, spacing and orientation of the tabular bodies, the origin and character of the downward flows required to explain the trough band schlieren structures is challenging. However, an intermittent and progressive deposition of trough bands, consistent with field observations, is potentially explained if the two-phase (crystals and melt) dynamics governing the response of the CPG magma to a new injection are considered.

The Bactericidal Effect of Shock Waves

NASA Astrophysics Data System (ADS)

Leighs, James; Appleby-Thomas, Gareth; Wood, David; Goff, Michael; Hameed, Amer; Hazell, Paul

2013-06-01

There are a variety of theories relating to the origins of life on our home planet, some of which discuss the possibility that life may have been spread via inter-planetary impacts. There have been a number of investigations into the ability of life to withstand the likely conditions generated by asteroid impact (both contained in the impactor and buried beneath the planet surface). Previously published data regarding the ability of bacteria to survive such applied shock waves has produced conflicting conclusions. The work presented here used an established technique, in combination with a single stage gas gun to shock load and subsequently recover Escherichia coli populations suspended in a phosphate buffered saline solution. Peak pressure across the sample region was calculated via numerical modelling, validated via Heterodyne velocimetry measurements. Survival data against peak sample pressure for recovered samples is presented alongside control tests.

Spectral restoration in high resolution electron energy loss spectroscopy based on iterative semi-blind Lucy-Richardson algorithm applied to rutile surfaces.

PubMed

Lazzari, Rémi; Li, Jingfeng; Jupille, Jacques

2015-01-01

A new spectral restoration algorithm of reflection electron energy loss spectra is proposed. It is based on the maximum likelihood principle as implemented in the iterative Lucy-Richardson approach. Resolution is enhanced and point spread function recovered in a semi-blind way by forcing cyclically the zero loss to converge towards a Dirac peak. Synthetic phonon spectra of TiO2 are used as a test bed to discuss resolution enhancement, convergence benefit, stability towards noise, and apparatus function recovery. Attention is focused on the interplay between spectral restoration and quasi-elastic broadening due to free carriers. A resolution enhancement by a factor up to 6 on the elastic peak width can be obtained on experimental spectra of TiO2(110) and helps revealing mixed phonon/plasmon excitations.

High-quality electron beam generation and bright betatron radiation from a cascaded laser wakefield accelerator (Conference Presentation)

NASA Astrophysics Data System (ADS)

Liu, Jiansheng; Wang, Wentao; Li, Wentao; Qi, Rong; Zhang, Zhijun; Yu, Changhai; Wang, Cheng; Liu, Jiaqi; Qing, Zhiyong; Ming, Fang; Xu, Yi; Leng, Yuxin; Li, Ruxin; Xu, Zhizhan

2017-05-01

One of the major goals of developing laser wakefiled accelerators (LWFAs) is to produce compact high-energy electron beam (e-beam) sources, which are expected to be applied in developing compact x-ray free-electron lasers and monoenergetic gamma-ray sources. Although LWFAs have been demonstrated to generate multi-GeV e-beams, to date they are still failed to produce high quality e beams with several essential properties (narrow energy spread, small transverse emittance and high beam charge) achieved simultaneously. Here we report on the demonstration of a high-quality cascaded LWFA experimentally via manipulating electron injection, seeding in different periods of the wakefield, as well as controlling energy chirp for the compression of energy spread. The cascaded LWFA was powered by a 1-Hz 200-TW femtosecond laser facility at SIOM. High-brightness e beams with peak energies in the range of 200-600 MeV, 0.4-1.2% rms energy spread, 10-80 pC charge, and 0.2 mrad rms divergence are experimentally obtained. Unprecedentedly high 6-dimensional (6-D) brightness B6D,n in units of A/m2/0.1% was estimated at the level of 1015-16, which is very close to the typical brightness of e beams from state-of-the-art linac drivers and several-fold higher than those of previously reported LWFAs. Furthermore, we propose a scheme to minimize the energy spread of an e beam in a cascaded LWFA to the one-thousandth-level by inserting a stage to compress its longitudinal spatial distribution via velocity bunching. In this scheme, three-segment plasma stages are designed for electron injection, e-beam length compression, and e-beam acceleration, respectively. A one-dimensional theory and two-dimensional particle-in-cell simulations have demonstrated this scheme and an e beam with 0.2% rms energy spread and low transverse emittance could be generated without loss of charge. Based on the high-quality e beams generated in the LWFA, we have experimentally realized a new scheme to enhance the betatron radiation via manipulating the e-beam transverse oscillation in the wakefield. Very brilliant quasi-monochromatic betatron x-rays in tens of keV with significant enhancement both in photon yield and peak energy have been generated. Besides, by employing a self-synchronized all-optical Compton scattering scheme, in which the electron beam collided with the intense driving laser pulse via the reflection of a plasma mirror, we produced tunable quasi-monochromatic MeV γ-rays ( 33% full-width at half-maximum) with a peak brilliance of 3.1×1022 photons s-1 mm-2 mrad-2 0.1% BW at 1 MeV, which is one order of magnitude higher than ever reported value in MeV regime to the best of our knowledge. 1. J. S. Liu, et al., Phys. Rev. Lett. 107, 035001 (2011). 2. X. Wang, et al., Nat. Commun. 4, 1988 (2013). 3. W. P. Leemans, et al., Phys. Rev. Lett. 113, 245002 (2014) 4. W. T. Wang et al., Phys. Rev. Lett. 117, 124801 (2016). 5. Z. J. Zhang et al., Phys. Plasmas 23, 053106 (2016). 6. C. H. Yu et al., Sci. Rep. 6, 29518 (2016).

Spatial and Temporal Distribution of Soil-Applied Neonicotinoids in Citrus Tree Foliage.

PubMed

Langdon, Kevin W; Schumann, Rhonda; Stelinski, Lukasz L; Rogers, Michael E

2018-04-23

Diaphorina citri Kuwayama (Hemiptera: Liviidae) is the insect vector of Candidatus Liberibacter asiaticus (CLas), the presumed cause of huanglongbing (HLB) in citrus (Rutaceae). Soil-applied neonicotinoids are used to manage vector populations and thus reduce the spread of HLB in Florida citrus. Studies were conducted in the greenhouse and field to quantify the spatial and temporal distribution of three neonicotinoid insecticides within individually sampled leaves and throughout the tree canopy. Following field application, no difference in parent material titer was observed between leaf middles versus leaf margins following application of Platinum 75SG or Belay 2.13SC; however, imidacloprid titer was higher in leaf margins than leaf middle following application of Admire Pro. The bottom region of trees contained more imidacloprid than other regions, but was not different from the spherical center region. In the greenhouse, imidacloprid and clothianidin titers peaked 5 wk following application of Admire and Belay, respectively, and thiamethoxam titer peaked 3 wk after application of Platinum. There was no effect of leaf age on uptakes of any insecticides tested. Titers of soil-applied neonicotinoids quantified in the field failed to reach known levels required to kill D. citri. Exposure of D. citri to sublethal dosages of neonicotinoids is of concern for HLB management because of possible failure to protect treated plants from D. citri and selection pressure for development of neonicotinoid resistance. Our results suggest that current soil-based use patterns of neonicotinoids for D. citri management may be suboptimal and require reevaluation to maintain the utility of this chemical class in citrus.

Cross-Level Effects Between Neurophysiology and Communication During Team Training.

PubMed

Gorman, Jamie C; Martin, Melanie J; Dunbar, Terri A; Stevens, Ronald H; Galloway, Trysha L; Amazeen, Polemnia G; Likens, Aaron D

2016-02-01

We investigated cross-level effects, which are concurrent changes across neural and cognitive-behavioral levels of analysis as teams interact, between neurophysiology and team communication variables under variations in team training. When people work together as a team, they develop neural, cognitive, and behavioral patterns that they would not develop individually. It is currently unknown whether these patterns are associated with each other in the form of cross-level effects. Team-level neurophysiology and latent semantic analysis communication data were collected from submarine teams in a training simulation. We analyzed whether (a) both neural and communication variables change together in response to changes in training segments (briefing, scenario, or debriefing), (b) neural and communication variables mutually discriminate teams of different experience levels, and (c) peak cross-correlations between neural and communication variables identify how the levels are linked. Changes in training segment led to changes in both neural and communication variables, neural and communication variables mutually discriminated between teams of different experience levels, and peak cross-correlations indicated that changes in communication precede changes in neural patterns in more experienced teams. Cross-level effects suggest that teamwork is not reducible to a fundamental level of analysis and that training effects are spread out across neural and cognitive-behavioral levels of analysis. Cross-level effects are important to consider for theories of team performance and practical aspects of team training. Cross-level effects suggest that measurements could be taken at one level (e.g., neural) to assess team experience (or skill) on another level (e.g., cognitive-behavioral). © 2015, Human Factors and Ergonomics Society.

Hydroclimatological And Anthropogenic Drivers For Cholera Spreading

NASA Astrophysics Data System (ADS)

Righetto, Lorenzo; Bertuzzo, Enrico; Mari, Lorenzo; Casagrandi, Renato; Gatto, Marino; Rinaldo, Andrea

2010-05-01

The nature of waterborne diseases, among which cholera has a prominent importance, calls for a better understanding of the link between epidemic spreading, water and climate. To this end, we have developed a framework which involves a network-based description of a river system, connected with local communities which act as nodes of the network. This has allowed us to produce consistent simulations of real case studies. More recent investigations comprise the evaluation of the spreading velocity of an epidemic wave by means of a reaction-diffusion modeling approach. In particular, we have found that both transport processes and epidemiological quantities, such as the basic reproduction number, have a crucial effect in controlling the spreading of the epidemics. We first developed a description of bacterial movement along the network driven by advection and diffusion; afterward, we have included the movement of human populations. This latter model allowed us to establish the conditions that can trigger epidemic waves that start from the coastal region, where bacteria are autochthonous, and travel inland. In particular, our findings suggest that even relatively low values of human diffusion can have the epidemic propagate upstream. The interaction between climate, hydrology and epidemic events is still much debated, since no clear correlation between climatologic and epidemiological phenomena has emerged so far. However, a spatial assessment of hydrological and epidemiological mechanisms could be crucial to understand the evolution of cholera outbreaks. In particular, a hotly debated topic is the understanding of the mechanisms that can generate patterns of cholera incidence that exhibit an intra-annual double peak, as frequently observed in endemic region such as Bangladesh. One of the possible explanations proposed in the literature is that spring droughts cause bacteria concentration in water to rise dramatically, triggering the first peak. On the other hand similar mechanisms can occur during flood recessions in autumn together with major water sanitation system failures and higher population density. We show here the results of an ecohydrological model that couples the dynamics of the disease to a description of both the local water reservoir and of the local river section. The goal of this modeling exercise is to reproduce and understand the mechanisms behind intra-annual cholera incidence dynamics driven by hydrologic variability.

Surgical Management of Perineural Spread of Head and Neck Cancers.

PubMed

Solares, C Arturo; Mason, Eric; Panizza, Benedict J

2016-04-01

The surgical management of perineural spread of head and neck cancers has become an integral part in the contemporary treatment of this pathology. We now understand that tumour spreads within the epineurium and in a continuous fashion. We also can rely on the accuracy of magnetic resonance neurography in detecting and defining the extent of disease. With modern skull base techniques and a greater understanding of the anatomy in this region, specific operations can be designed to help eradicate disease. We review the current approaches and techniques used that enable us to better obtain tumour free margins and hence improve survival.

A maximum (non-extensive) entropy approach to equity options bid-ask spread

NASA Astrophysics Data System (ADS)

Tapiero, Oren J.

2013-07-01

The cross-section of options bid-ask spreads with their strikes are modelled by maximising the Kaniadakis entropy. A theoretical model results with the bid-ask spread depending explicitly on the implied volatility; the probability of expiring at-the-money and an asymmetric information parameter (κ). Considering AIG as a test case for the period between January 2006 and October 2008, we find that information flows uniquely from the trading activity in the underlying asset to its derivatives. Suggesting that κ is possibly an option implied measure of the current state of trading liquidity in the underlying asset.

Measured close lightning leader-step electric-field-derivative waveforms.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jordan, Doug M.; Hill, Dustin; Biagi, Christopher J.

2010-12-01

We characterize the measured electric field-derivative (dE/dt) waveforms of lightning stepped-leader steps from three negative lightning flashes at distances of tens to hundreds of meters. Electromagnetic signatures of leader steps at such close distances have rarely been documented in previous literature. Individual leader-step three-dimensional locations are determined by a dE/dt TOA system. The leader-step field derivative is typically a bipolar pulse with a sharp initial half-cycle of the same polarity as that of the return stroke, followed by an opposite polarity overshoot that decays relatively slowly to background level. This overshoot increases in amplitude relative to the initial peak andmore » becomes dominant as range decreases. The initial peak is often preceded by a 'slow front,' similar to the slow front that precedes the fast transition to peak in first return stroke dE/dt and E waveforms. The overall step-field waveform duration is typically less than 1 {micro}s. The mean initial peak of dE/dt, range-normalized to 100 km, is 7.4 V m{sup -1} {micro}s{sup -1} (standard deviation (S.D.), 3.7 V m{sup -1} {micro}s{sup -1}, N = 103), the mean half-peak width is 33.5 ns (S.D., 11.9 ns, N = 69), and the mean 10-to-90% risetime is 43.6 ns (S.D., 24.2 ns, N = 69). From modeling, we determine the properties of the leader step currents which produced two typical measured field derivatives, and we use one of these currents to calculate predicted leader step E and dE/dt as a function of source range and height, the results being in good agreement with our observations. The two modeled current waveforms had maximum rates of current rise-to-peak near 100 kA {micro}s{sup -1}, peak currents in the 5-7 kA range, current half-peak widths of about 300 ns, and charge transfers of {approx}3 mC. As part of the modeling, those currents were propagated upward at 1.5 x 10{sup 8} m s{sup -1}, with their amplitudes decaying exponentially with a decay height constant of 25 m.« less

Evaluation of Lightning Incidence to Elements of a Complex Structure: A Monte Carlo Approach

NASA Technical Reports Server (NTRS)

Mata, Carlos T.; Rakov, V. A.

2008-01-01

There are complex structures for which the installation and positioning of the lightning protection system (LPS) cannot be done using the lightning protection standard guidelines. As a result, there are some "unprotected" or "exposed" areas. In an effort to quantify the lightning threat to these areas, a Monte Carlo statistical tool has been developed. This statistical tool uses two random number generators: a uniform distribution to generate origins of downward propagating leaders and a lognormal distribution to generate returns stroke peak currents. Downward leaders propagate vertically downward and their striking distances are defined by the polarity and peak current. Following the electrogeometrical concept, we assume that the leader attaches to the closest object within its striking distance. The statistical analysis is run for 10,000 years with an assumed ground flash density and peak current distributions, and the output of the program is the probability of direct attachment to objects of interest with its corresponding peak current distribution.

Author Correction: Low frequency transcranial electrical stimulation does not entrain sleep rhythms measured by human intracranial recordings.

PubMed

Lafon, Belen; Henin, Simon; Huang, Yu; Friedman, Daniel; Melloni, Lucia; Thesen, Thomas; Doyle, Werner; Buzsáki, György; Devinsky, Orrin; Parra, Lucas C; Liu, Anli

2018-02-28

It has come to our attention that we did not specify whether the stimulation magnitudes we report in this Article are peak amplitudes or peak-to-peak. All references to intensity given in mA in the manuscript refer to peak-to-peak amplitudes, except in Fig. 2, where the model is calibrated to 1 mA peak amplitude, as stated. In the original version of the paper we incorrectly calibrated the computational models to 1 mA peak-to-peak, rather than 1 mA peak amplitude. This means that we divided by a value twice as large as we should have. The correct estimated fields are therefore twice as large as shown in the original Fig. 2 and Supplementary Figure 11. The corrected figures are now properly calibrated to 1 mA peak amplitude. Furthermore, the sentence in the first paragraph of the Results section 'Intensity ranged from 0.5 to 2.5 mA (current density 0.125-0.625 mA mA/cm 2 ), which is stronger than in previous reports', should have read 'Intensity ranged from 0.5 to 2.5 mA peak to peak (peak current density 0.0625-0.3125 mA/cm 2 ), which is stronger than in previous reports.' These errors do not affect any of the Article's conclusions.

Electrical stimulation of the midbrain excites the auditory cortex asymmetrically.

PubMed

Quass, Gunnar Lennart; Kurt, Simone; Hildebrandt, Jannis; Kral, Andrej

2018-05-17

Auditory midbrain implant users cannot achieve open speech perception and have limited frequency resolution. It remains unclear whether the spread of excitation contributes to this issue and how much it can be compensated by current-focusing, which is an effective approach in cochlear implants. The present study examined the spread of excitation in the cortex elicited by electric midbrain stimulation. We further tested whether current-focusing via bipolar and tripolar stimulation is effective with electric midbrain stimulation and whether these modes hold any advantage over monopolar stimulation also in conditions when the stimulation electrodes are in direct contact with the target tissue. Using penetrating multielectrode arrays, we recorded cortical population responses to single pulse electric midbrain stimulation in 10 ketamine/xylazine anesthetized mice. We compared monopolar, bipolar, and tripolar stimulation configurations with regard to the spread of excitation and the characteristic frequency difference between the stimulation/recording electrodes. The cortical responses were distributed asymmetrically around the characteristic frequency of the stimulated midbrain region with a strong activation in regions tuned up to one octave higher. We found no significant differences between monopolar, bipolar, and tripolar stimulation in threshold, evoked firing rate, or dynamic range. The cortical responses to electric midbrain stimulation are biased towards higher tonotopic frequencies. Current-focusing is not effective in direct contact electrical stimulation. Electrode maps should account for the asymmetrical spread of excitation when fitting auditory midbrain implants by shifting the frequency-bands downward and stimulating as dorsally as possible. Copyright © 2018 Elsevier Inc. All rights reserved.

Numerical Modeling of Infragravity Wave Runup on Steep and Mildly Sloping Natural Beaches

NASA Astrophysics Data System (ADS)

Fiedler, J. W.; Smit, P.; Brodie, K. L.; McNinch, J.; Guza, R. T.; Gallien, T.

2016-12-01

We present ongoing work which aims to validate the non-hydrostatic model SWASH for wave runup and infragravity waves generated by a range of different incident wave spectra at the offshore boundary, including the effect of finite directional spread. Flume studies of wave runup are limited to normally incident (1D) sea and infragravity waves, but natural waves are directionally spread (2D), with substantially different dynamics from 1D. For example, refractive trapping (edge waves) is only possible with 2D waves, and the bound infragravity wave response to short wave groups is highly amplified for the special case of normal incidence. Selected case studies are modeled at Agate Beach, Oregon, a low slope (1:80) beach with maximum offshore wave heights greater than 7m, and Cardiff, California, a steep (1:8) beach with maximum wave heights of 2m. Peak periods ranged between 5-20 s at both sites. On both beaches, waves were measured on a transect from approximately 10m depth to the runup, using pressure sensors, current meters, and a scanning lidar. Bulk short wave quantities, wave runup, infragravity frequency spectra and energy fluxes are compared with SWASH. On the low slope beach with energetic incident waves, the observed horizontal runup excursions reach 140m ( 100s periods). Swash front velocities reached up to several m/s, causing short waves to stack up during runup drawdown. On reversal of the infragravity phase, the stacked short waves are swept onshore with the long wave front, effectively enhancing runup by phase coupling long and short waves. Statistical variability and nonlinearity in swash generation lead to time-varying runup heights. Here, we test these observations with 2D SWASH, as well as the sensitivity of modeled runup to the parameterization of bottom friction.

Phocine distemper virus (PDV) seroprevalence as predictor for future outbreaks in harbour seals.

PubMed

Ludes-Wehrmeister, Eva; Dupke, Claudia; Harder, Timm C; Baumgärtner, Wolfgang; Haas, Ludwig; Teilmann, Jonas; Dietz, Rune; Jensen, Lasse F; Siebert, Ursula

2016-02-01

Phocine distemper virus (PDV) infections caused the two most pronounced mass mortalities in marine mammals documented in the past century. During the two outbreaks, 23,000 and 30,000 harbour seals (Phoca vitulina), died in 1988/1989 and 2002 across populations in the Wadden Sea and adjacent waters, respectively. To follow the mechanism and development of disease spreading, the dynamics of Morbillivirus-specific antibodies in harbour seal populations in German and Danish waters were examined. 522 serum samples of free-ranging harbour seals of different ages were sampled between 1990 and 2014. By standard neutralisation assays, Morbillivirus-specific antibodies were detected, using either the PDV isolate 2558/Han 88 or the related canine distemper virus (CDV) strain Onderstepoort. A total of 159 (30.5%) of the harbour seals were seropositive. Annual seroprevalence rates showed an undulating course: Peaks were seen in the post-epidemic years 1990/1991 and 2002/2003. Following each PDV outbreak, seroprevalence decreased and six to eight years after the epidemics samples were tested seronegative, indicating that the populations are now again susceptible to new PDV outbreak. After the last outbreak in 2002, the populations grew steadily to an estimated maximum (since 1975) of about 39,100 individuals in the Wadden Sea in 2014 and about 23,540 harbour seals in the Kattegat area in 2013. A re-appearence of PDV would presumably result in another epizootic with high mortality rates as encountered in the previous outbreaks. The current high population density renders harbour seals vulnerable to rapid spread of infectious agents including PDV and the recently detected influenza A virus. Copyright © 2015 Elsevier B.V. All rights reserved.

Aqueous synthesis of zinc oxide films for GaN optoelectronic devices

NASA Astrophysics Data System (ADS)

Reading, Arthur H.

GaN-based LEDs have generally made use of ITO transparent contacts as current-spreading layers for uniform current injection. However, the high raw material and processing costs of ITO layers have generated interest in potentially cheaper alternatives. In this work, zinc oxide transparent layers were fabricated by a low-cost, low-temperature aqueous epitaxial growth method at 90°C for use as transparent contacts to GaN LEDs on c-plane sapphire, and on semipolar bulk GaN substrates. Low-voltage operation was achieved for c-plane devices, with voltages below 3.8V for 1mm2 broad-area LEDs at a current density of 30A/cm 2. Blue-green LEDs on 202¯1¯-plane GaN also showed low voltage operation below 3.5V at 30A/cm2. Ohmic contact resistivity of 1:8 x 10-2Ocm2 was measured for films on (202¯1) p-GaN templates. Ga-doped films had electrical conductivities as high as 660S/cm after annealing at 300°C. Optical characterization revealed optical absorption coefficients in the 50--200cm -1 range for visible light, allowing thick films with sheet resistances below 10O/□ to be grown while minimizing absorption of the emitted light. Accurate and reproducible etch-free patterning of the ZnO films was achieved using templated growths with SiOx hard masks. A roughening method is described which was found to increase peak LED efficiencies by 13% on c-plane patterned sapphire (PSS) substrates. In addition, ZnO films were successfully employed as laser-cladding layers for blue (202¯1) lasers, with a threshold current density of 8.8kA/cm 2.

Qualitative risk assessment in a data-scarce environment: a model to assess the impact of control measures on spread of African Swine Fever.

PubMed

Wieland, Barbara; Dhollander, Sofie; Salman, Mo; Koenen, Frank

2011-04-01

In the absence of data, qualitative risk assessment frameworks have proved useful to assess risks associated with animal health diseases. As part of a scientific opinion for the European Commission (EC) on African Swine Fever (ASF), a working group of the European Food Safety Authority (EFSA) assessed the risk of ASF remaining endemic in Trans Caucasus Countries (TCC) and the Russian Federation (RF) and the risk of ASF becoming endemic in the EU if disease were introduced. The aim was to develop a tool to evaluate how current control or preventive measures mitigate the risk of spread and giving decision makers the means to review how strengthening of surveillance and control measures would mitigate the risk of disease spread. Based on a generic model outlining disease introduction, spread and endemicity in a region, the impact of risk mitigation measures on spread of disease was assessed for specific risk questions. The resulting hierarchical models consisted of key steps containing several sub-steps. For each step of the risk pathways risk estimates were determined by the expert group based on existing data or through expert opinion elicitation. Risk estimates were combined using two different combination matrices, one to combine estimates of independent steps and one to combine conditional probabilities. The qualitative risk assessment indicated a moderate risk that ASF will remain endemic in current affected areas in the TCC and RF and a high risk of spread to currently unaffected areas. If introduced into the EU, ASF is likely to be controlled effectively in the production sector with high or limited biosecurity. In the free range production sector, however, there is a moderate risk of ASF becoming endemic due to wild boar contact, non-compliance with animal movement bans, and difficult access to all individual pigs upon implementation of control measures. This study demonstrated the advantages of a systematic framework to assist an expert panel to carry out a risk assessment as it helped experts to disassociate steps in the risk pathway and to overcome preconceived notions of final risk estimates. The approach presented here shows how a qualitative risk assessment framework can address animal diseases with complexity in their spread and control measures and how transparency of the resulting estimates was achieved. Copyright © 2011 Elsevier B.V. All rights reserved.

Substrate stress relaxation regulates cell spreading

NASA Astrophysics Data System (ADS)

Chaudhuri, Ovijit; Gu, Luo; Darnell, Max; Klumpers, Darinka; Bencherif, Sidi A.; Weaver, James C.; Huebsch, Nathaniel; Mooney, David J.

2015-02-01

Studies of cellular mechanotransduction have converged upon the idea that cells sense extracellular matrix (ECM) elasticity by gauging resistance to the traction forces they exert on the ECM. However, these studies typically utilize purely elastic materials as substrates, whereas physiological ECMs are viscoelastic, and exhibit stress relaxation, so that cellular traction forces exerted by cells remodel the ECM. Here we investigate the influence of ECM stress relaxation on cell behaviour through computational modelling and cellular experiments. Surprisingly, both our computational model and experiments find that spreading for cells cultured on soft substrates that exhibit stress relaxation is greater than cells spreading on elastic substrates of the same modulus, but similar to that of cells spreading on stiffer elastic substrates. These findings challenge the current view of how cells sense and respond to the ECM.

Rupture and Spreading Dynamics of Lipid Membranes on a Solid Surface

NASA Astrophysics Data System (ADS)

Perazzo, Antonio; Shin, Sangwoo; Colosqui, Carlos; Young, Yuan-Nan; Stone, Howard A.

2017-11-01

The spreading of lipid membranes on solid surfaces is a dynamic phenomenon relevant to drug delivery, endocytosis, biofouling, and the synthesis of supported lipid bilayers. Current technological developments are limited by an incomplete understanding of the spreading and adhesion dynamics of a lipid bilayer under different physicochemical conditions. Here, we present recent experimental and theoretical results for the spreading of giant unilamellar vesicles (GUVs), where the vesicle shell consists of a lipid bilayer. In particular, we study the effect of different background ion concentrations, osmolarity mismatches between the interior and the exterior of the vesicles, and different surface chemistries of the glass substrate. In all of the studied cases, we observe a delay time before a GUV in contact with the solid surface eventually ruptures. The rupture kinetics and subsequent spreading dynamics is controlled by the ionic screening within the thin film of liquid between the vesicle and the surface. Different rupture mechanisms, mobilities of the spreading vesicle, and degrees of substrate coverage are observed by varying the electrolyte concentration, solid surface charge, and osmolarity mismatch.

Modeling and optimization of a double-well double-barrier GaN/AlGaN/GaN/AlGaN resonant tunneling diode

NASA Astrophysics Data System (ADS)

Liu, Yang; Gao, Bo; Gong, Min; Shi, Ruiying

2017-06-01

The influence of a GaN layer as a sub-quantum well for an AlGaN/GaN/AlGaN double barrier resonant tunneling diode (RTD) on device performance has been investigated by means of numerical simulation. The introduction of the GaN layer as the sub-quantum well turns the dominant transport mechanism of RTD from the 3D-2D model to the 2D-2D model and increases the energy difference between tunneling energy levels. It can also lower the effective height of the emitter barrier. Consequently, the peak current and peak-to-valley current difference of RTD have been increased. The optimal GaN sub-quantum well parameters are found through analyzing the electrical performance, energy band, and transmission coefficient of RTD with different widths and depths of the GaN sub-quantum well. The most pronounced electrical parameters, a peak current density of 5800 KA/cm2, a peak-to-valley current difference of 1.466 A, and a peak-to-valley current ratio of 6.35, could be achieved by designing RTD with the active region structure of GaN/Al0.2Ga0.8 N/GaN/Al0.2Ga0.8 N (3 nm/1.5 nm/1.5 nm/1.5 nm).

Simulation of emittance dilution in electron storage ring from Compton backscattering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blumberg, L.N.; Blum, E.

1993-07-01

A Monte-Carlo simulation of Compton backscattered {kappa}{sub L}=3.2-{mu}m photons from an IR-FEL on 75-MeV electrons in a storage ring yields an RMS electron energy spread of {Delta}{sub E}=11.9-keV for a sample of 10{sup 7} single scattering events. Electrons are sampled from a beam of natural energy spread {sigma}{sub E} = 5.6-keV and damped transverse angle spreads {sigma}{sub x}{prime}, = .041-mrad and {sigma}{sub y}{prime} = .052-mrad (100%) coupling, scaled from the 200-MeV BNL XLS compact storage ring. The Compton-scattered X-Rays are generated from an integral of the CM Klein-Nishina cross-section transformed to the lab. A tracking calculation has also been performedmore » in 6-dimensional phase space. Initial electron coordinates are selected randomly from a Gaussian distribution of RMS spreads {sigma}{sub xo}=.102-mm, {sigma}{sub x{prime}o}=.041-mrad, {sigma}{sub yo}=.018-mm, {sigma}{sub y{prime}o}=.052-mrad, {sigma}{sub {phi}o}=22-mrad and {sigma}{sub Eo}=6-keV. A sample of 10000 electrons were each following for 40000 turns around the ring through an RF cavity of f{sub rf}=211.54-MHz and peak voltage V{sub m}=300-keV. Preliminary results indicate that the resulting energy distribution is quite broad with an RMS width of {Delta}{sub E} = 124-keV. The transverse widths are only slightly increased from their original values, i.e. {Delta}{sub x} = .106-mm and {Delta}{sub x}{prime}=.043 mrad. The scaled energy spread of {Delta}{sub E} {approximately} 360-keV for {approximately} 350,000 turns desired in a 10-msec X-Ray angiography exposure is well within the RF bucket used here; even V{sub m} < 50-kV is adequate. Further, the electron energy spread adds a negligible RMS X-Ray energy spread of {Delta}{sub Ex}=.32-keV. The electron energy damping time of {tau}{sub E}=379-msec at 75-MeV in an XLS-type ring allows for damping this induced spread and top-off of the ring between heart cycles.« less

Statistical survey of widely spread out solar electron events observed with STEREO and ACE with special attention to anisotropies

NASA Astrophysics Data System (ADS)

Dresing, N.; Gómez-Herrero, R.; Heber, B.; Klassen, A.; Malandraki, O.; Dröge, W.; Kartavykh, Y.

2014-07-01

Context. In February 2011, the two STEREO spacecrafts reached a separation of 180 degrees in longitude, offering a complete view of the Sun for the first time ever. When the full Sun surface is visible, source active regions of solar energetic particle (SEP) events can be identified unambiguously. STEREO, in combination with near-Earth observatories such as ACE or SOHO, provides three well separated viewpoints, which build an unprecedented platform from which to investigate the longitudinal variations of SEP events. Aims: We show an ensemble of SEP events that were observed between 2009 and mid-2013 by at least two spacecrafts and show a remarkably wide particle spread in longitude (wide-spread events). The main selection criterion for these events was a longitudinal separation of at least 80 degrees between active region and spacecraft magnetic footpoint for the widest separated spacecraft. We investigate the events statistically in terms of peak intensities, onset delays, and rise times, and determine the spread of the longitudinal events, which is the range filled by SEPs during the events. Energetic electron anisotropies are investigated to distinguish the source and transport mechanisms that lead to the observed wide particle spreads. Methods: According to the anisotropy distributions, we divided the events into three classes depending on different source and transport scenarios. One potential mechanism for wide-spread events is efficient perpendicular transport in the interplanetary medium that competes with another scenario, which is a wide particle spread that occurs close to the Sun. In the latter case, the observations at 1 AU during the early phase of the events are expected to show significant anisotropies because of the wide injection range at the Sun and particle-focusing during the outward propagation, while in the first case only low anisotropies are anticipated. Results: We find events for both of these scenarios in our sample that match the expected observations and even different events that do not agree with the scenarios. We conclude that probably both an extended source region at the Sun and perpendicular transport in the interplanetary medium are involved for most of these wide-spread events. Appendix A is available in electronic form at http://www.aanda.org

Glutathionylation-Dependence of Na+-K+-Pump Currents Can Mimic Reduced Subsarcolemmal Na+ Diffusion

PubMed Central

Garcia, Alvaro; Liu, Chia-Chi; Cornelius, Flemming; Clarke, Ronald J.; Rasmussen, Helge H.

2016-01-01

The existence of a subsarcolemmal space with restricted diffusion for Na+ in cardiac myocytes has been inferred from a transient peak electrogenic Na+-K+ pump current beyond steady state on reexposure of myocytes to K+ after a period of exposure to K+-free extracellular solution. The transient peak current is attributed to enhanced electrogenic pumping of Na+ that accumulated in the diffusion-restricted space during pump inhibition in K+-free extracellular solution. However, there are no known physical barriers that account for such restricted Na+ diffusion, and we examined if changes of activity of the Na+-K+ pump itself cause the transient peak current. Reexposure to K+ reproduced a transient current beyond steady state in voltage-clamped ventricular myocytes as reported by others. Persistence of it when the Na+ concentration in patch pipette solutions perfusing the intracellular compartment was high and elimination of it with K+-free pipette solution could not be reconciled with restricted subsarcolemmal Na+ diffusion. The pattern of the transient current early after pump activation was dependent on transmembrane Na+- and K+ concentration gradients suggesting the currents were related to the conformational poise imposed on the pump. We examined if the currents might be accounted for by changes in glutathionylation of the β1 Na+-K+ pump subunit, a reversible oxidative modification that inhibits the pump. Susceptibility of the β1 subunit to glutathionylation depends on the conformational poise of the Na+-K+ pump, and glutathionylation with the pump stabilized in conformations equivalent to those expected to be imposed on voltage-clamped myocytes supported this hypothesis. So did elimination of the transient K+-induced peak Na+-K+ pump current when we included glutaredoxin 1 in patch pipette solutions to reverse glutathionylation. We conclude that transient K+-induced peak Na+-K+ pump current reflects the effect of conformation-dependent β1 pump subunit glutathionylation, not restricted subsarcolemmal diffusion of Na+. PMID:26958887

Glutathionylation-Dependence of Na(+)-K(+)-Pump Currents Can Mimic Reduced Subsarcolemmal Na(+) Diffusion.

PubMed

Garcia, Alvaro; Liu, Chia-Chi; Cornelius, Flemming; Clarke, Ronald J; Rasmussen, Helge H

2016-03-08

The existence of a subsarcolemmal space with restricted diffusion for Na(+) in cardiac myocytes has been inferred from a transient peak electrogenic Na(+)-K(+) pump current beyond steady state on reexposure of myocytes to K(+) after a period of exposure to K(+)-free extracellular solution. The transient peak current is attributed to enhanced electrogenic pumping of Na(+) that accumulated in the diffusion-restricted space during pump inhibition in K(+)-free extracellular solution. However, there are no known physical barriers that account for such restricted Na(+) diffusion, and we examined if changes of activity of the Na(+)-K(+) pump itself cause the transient peak current. Reexposure to K(+) reproduced a transient current beyond steady state in voltage-clamped ventricular myocytes as reported by others. Persistence of it when the Na(+) concentration in patch pipette solutions perfusing the intracellular compartment was high and elimination of it with K(+)-free pipette solution could not be reconciled with restricted subsarcolemmal Na(+) diffusion. The pattern of the transient current early after pump activation was dependent on transmembrane Na(+)- and K(+) concentration gradients suggesting the currents were related to the conformational poise imposed on the pump. We examined if the currents might be accounted for by changes in glutathionylation of the β1 Na(+)-K(+) pump subunit, a reversible oxidative modification that inhibits the pump. Susceptibility of the β1 subunit to glutathionylation depends on the conformational poise of the Na(+)-K(+) pump, and glutathionylation with the pump stabilized in conformations equivalent to those expected to be imposed on voltage-clamped myocytes supported this hypothesis. So did elimination of the transient K(+)-induced peak Na(+)-K(+) pump current when we included glutaredoxin 1 in patch pipette solutions to reverse glutathionylation. We conclude that transient K(+)-induced peak Na(+)-K(+) pump current reflects the effect of conformation-dependent β1 pump subunit glutathionylation, not restricted subsarcolemmal diffusion of Na(+). Copyright © 2016 Biophysical Society. Published by Elsevier Inc. All rights reserved.

Generation of field potentials and modulation of their dynamics through volume integration of cortical activity.

PubMed

Kajikawa, Yoshinao; Schroeder, Charles E

2015-01-01

Field potentials (FPs) recorded within the brain, often called "local field potentials" (LFPs), are useful measures of net synaptic activity in a neuronal ensemble. However, due to volume conduction, FPs spread beyond regions of underlying synaptic activity, and thus an "LFP" signal may not accurately reflect the temporal patterns of synaptic activity in the immediately surrounding neuron population. To better understand the physiological processes reflected in FPs, we explored the relationship between the FP and its membrane current generators using current source density (CSD) analysis in conjunction with a volume conductor model. The model provides a quantitative description of the spatiotemporal summation of immediate local and more distant membrane currents to produce the FP. By applying the model to FPs in the macaque auditory cortex, we have investigated a critical issue that has broad implications for FP research. We have shown that FP responses in particular cortical layers are differentially susceptible to activity in other layers. Activity in the supragranular layers has the strongest contribution to FPs in other cortical layers, and infragranular FPs are most susceptible to contributions from other layers. To define the physiological processes generating FPs recorded in loci of relatively weak synaptic activity, strong effects produced by synaptic events in the vicinity have to be taken into account. While outlining limitations and caveats inherent to FP measurements, our results also suggest specific peak and frequency band components of FPs can be related to activity in specific cortical layers. These results may help improving the interpretability of FPs. Copyright © 2015 the American Physiological Society.

Generation of field potentials and modulation of their dynamics through volume integration of cortical activity

PubMed Central

Schroeder, Charles E.

2014-01-01

Field potentials (FPs) recorded within the brain, often called “local field potentials” (LFPs), are useful measures of net synaptic activity in a neuronal ensemble. However, due to volume conduction, FPs spread beyond regions of underlying synaptic activity, and thus an “LFP” signal may not accurately reflect the temporal patterns of synaptic activity in the immediately surrounding neuron population. To better understand the physiological processes reflected in FPs, we explored the relationship between the FP and its membrane current generators using current source density (CSD) analysis in conjunction with a volume conductor model. The model provides a quantitative description of the spatiotemporal summation of immediate local and more distant membrane currents to produce the FP. By applying the model to FPs in the macaque auditory cortex, we have investigated a critical issue that has broad implications for FP research. We have shown that FP responses in particular cortical layers are differentially susceptible to activity in other layers. Activity in the supragranular layers has the strongest contribution to FPs in other cortical layers, and infragranular FPs are most susceptible to contributions from other layers. To define the physiological processes generating FPs recorded in loci of relatively weak synaptic activity, strong effects produced by synaptic events in the vicinity have to be taken into account. While outlining limitations and caveats inherent to FP measurements, our results also suggest specific peak and frequency band components of FPs can be related to activity in specific cortical layers. These results may help improving the interpretability of FPs. PMID:25274348

The target material influence on the current pulse during high power pulsed magnetron sputtering

NASA Astrophysics Data System (ADS)

Moens, Filip; Konstantinidis, Stéphanos; Depla, Diederik

2017-10-01

The current-time characteristic during high power pulsed magnetron sputtering is measured under identical conditions for seventeen different target materials. Based on physical processes such as gas rarefaction, ion-induced electron emission, and electron impact ionization, two test parameters were derived that significantly correlate with specific features of the current-time characteristic: i) the peak current is correlated to the momentum transfer between the sputtered material and the argon gas, ii) while the observed current plateau after the peak is connected to the metal ionization rate.

Respiratory syncytial virus tracking using internet search engine data.

PubMed

Oren, Eyal; Frere, Justin; Yom-Tov, Eran; Yom-Tov, Elad

2018-04-03

Respiratory Syncytial Virus (RSV) is the leading cause of hospitalization in children less than 1 year of age in the United States. Internet search engine queries may provide high resolution temporal and spatial data to estimate and predict disease activity. After filtering an initial list of 613 symptoms using high-resolution Bing search logs, we used Google Trends data between 2004 and 2016 for a smaller list of 50 terms to build predictive models of RSV incidence for five states where long-term surveillance data was available. We then used domain adaptation to model RSV incidence for the 45 remaining US states. Surveillance data sources (hospitalization and laboratory reports) were highly correlated, as were laboratory reports with search engine data. The four terms which were most often statistically significantly correlated as time series with the surveillance data in the five state models were RSV, flu, pneumonia, and bronchiolitis. Using our models, we tracked the spread of RSV by observing the time of peak use of the search term in different states. In general, the RSV peak moved from south-east (Florida) to the north-west US. Our study represents the first time that RSV has been tracked using Internet data results and highlights successful use of search filters and domain adaptation techniques, using data at multiple resolutions. Our approach may assist in identifying spread of both local and more widespread RSV transmission and may be applicable to other seasonal conditions where comprehensive epidemiological data is difficult to collect or obtain.

Mitogenic stimulation accelerates influenza-induced mortality by increasing susceptibility of alveolar type II cells to infection

PubMed Central

Noel, John G.; Pitstick, Lori B.; Gardner, Jason C.; Uehara, Yasuaki; Wu, Huixing; Saito, Atsushi; Lewnard, Kara E.; Liu, Huan; White, Mitchell R.; Hartshorn, Kevan L.; McCormack, Francis X.

2017-01-01

Development of pneumonia is the most lethal consequence of influenza, increasing mortality more than 50-fold compared with uncomplicated infection. The spread of viral infection from conducting airways to the alveolar epithelium is therefore a pivotal event in influenza pathogenesis. We found that mitogenic stimulation with keratinocyte growth factor (KGF) markedly accelerated mortality after infectious challenge with influenza A virus (IAV). Coadministration of KGF with IAV markedly accelerated the spread of viral infection from the airways to alveoli compared with challenge with IAV alone, based on spatial and temporal analyses of viral nucleoprotein staining of lung tissue sections and dissociated lung cells. To better define the temporal relationship between KGF administration and susceptibility to IAV infection in vivo, we administered KGF 120, 48, 24, and 0 h before intrapulmonary IAV challenge and assessed the percentages of proliferating and IAV-infected, alveolar type II (AECII) cells in dispersed lung cell populations. Peak AECII infectivity coincided with the timing of KGF administration that also induced peak AECII proliferation. AECII from mice that were given intrapulmonary KGF before isolation and then infected with IAV ex vivo exhibited the same temporal pattern of proliferation and infectious susceptibility. KGF-induced increases in mortality, AECII proliferation, and enhanced IAV susceptibility were all reversed by pretreatment of the animals with the mTOR inhibitor rapamycin before mitogenic stimulation. Taken together, these data suggest mTOR signaling-dependent, mitogenic conditioning of AECII is a determinant of host susceptibility to infection with IAV. PMID:28739896

Mitogenic stimulation accelerates influenza-induced mortality by increasing susceptibility of alveolar type II cells to infection.

PubMed

Nikolaidis, Nikolaos M; Noel, John G; Pitstick, Lori B; Gardner, Jason C; Uehara, Yasuaki; Wu, Huixing; Saito, Atsushi; Lewnard, Kara E; Liu, Huan; White, Mitchell R; Hartshorn, Kevan L; McCormack, Francis X

2017-08-08

Development of pneumonia is the most lethal consequence of influenza, increasing mortality more than 50-fold compared with uncomplicated infection. The spread of viral infection from conducting airways to the alveolar epithelium is therefore a pivotal event in influenza pathogenesis. We found that mitogenic stimulation with keratinocyte growth factor (KGF) markedly accelerated mortality after infectious challenge with influenza A virus (IAV). Coadministration of KGF with IAV markedly accelerated the spread of viral infection from the airways to alveoli compared with challenge with IAV alone, based on spatial and temporal analyses of viral nucleoprotein staining of lung tissue sections and dissociated lung cells. To better define the temporal relationship between KGF administration and susceptibility to IAV infection in vivo, we administered KGF 120, 48, 24, and 0 h before intrapulmonary IAV challenge and assessed the percentages of proliferating and IAV-infected, alveolar type II (AECII) cells in dispersed lung cell populations. Peak AECII infectivity coincided with the timing of KGF administration that also induced peak AECII proliferation. AECII from mice that were given intrapulmonary KGF before isolation and then infected with IAV ex vivo exhibited the same temporal pattern of proliferation and infectious susceptibility. KGF-induced increases in mortality, AECII proliferation, and enhanced IAV susceptibility were all reversed by pretreatment of the animals with the mTOR inhibitor rapamycin before mitogenic stimulation. Taken together, these data suggest mTOR signaling-dependent, mitogenic conditioning of AECII is a determinant of host susceptibility to infection with IAV.

RBE and OER within the spread-out Bragg peak for proton beam therapy: in vitro study at the Proton Medical Research Center at the University of Tsukuba

PubMed Central

Kanemoto, Ayae; Hirayama, Ryoichi; Moritake, Takashi; Furusawa, Yoshiya; Sun, Lue; Sakae, Takeji; Kuno, Akihiro; Terunuma, Toshiyuki; Yasuoka, Kiyoshi; Mori, Yutaro; Tsuboi, Koji; Sakurai, Hideyuki

2014-01-01

There are few reports on the biological homogeneity within the spread-out Bragg peak (SOBP) of proton beams. Therefore, to evaluate the relative biological effectiveness (RBE) and the oxygen enhancement ratio (OER), human salivary gland tumor (HSG) cells were irradiated at the plateau position (position A) and three different positions within a 6-cm-wide SOBP (position B, 26 mm proximal to the middle; position C, middle; position D, 26 mm distal to the middle) using 155-MeV/n proton beams under both normoxic and hypoxic conditions at the Proton Medical Research Center, University of Tsukuba, Japan. The RBE to the plateau region (RBEplateau) and the OER value were calculated from the doses corresponding to 10% survival data. Under the normoxic condition, the RBEplateau was 1.00, 0.99 and 1.09 for positions B, C and D, respectively. Under the hypoxic condition, the RBEplateau was 1.10, 1.06 and 1.12 for positions B, C and D, respectively. The OER was 2.84, 2.60, 2.63 and 2.76 for positions A, B, C and D, respectively. There were no significant differences in either the RBEplateau or the OER between these three positions within the SOBP. In conclusion, biological homogeneity need not necessarily be taken into account for treatment planning for proton beam therapy at the University of Tsukuba. PMID:24876271

Chemical study of the metal-rich globular cluster NGC 5927

NASA Astrophysics Data System (ADS)

Mura-Guzmán, A.; Villanova, S.; Muñoz, C.; Tang, B.

2018-03-01

Globular clusters (GCs) are natural laboratories where stellar and chemical evolution can be studied in detail. In addition, their chemical patterns and kinematics can tell us to which Galactic structure (disc, bulge, halo or extragalactic) the cluster belongs to. NGC 5927 is one of most metal-rich GCs in the Galaxy and its kinematics links it to the thick disc. We present abundance analysis based on high-resolution spectra of seven giant stars. The data were obtained using Fibre Large Array Multi Element Spectrograph/Ultraviolet Echelle Spectrograph (UVES) spectrograph mounted on UT2 telescope of the European Southern Observatory. The principal objective of this work is to perform a wide and detailed chemical abundance analysis of the cluster and look for possible Multiple Populations (MPs). We determined stellar parameters and measured 22 elements corresponding to light (Na, Al), alpha (O, Mg, Si, Ca, Ti), iron-peak (Sc, V, Cr, Mn, Fe, Co, Ni, Cu, Zn), and heavy elements (Y, Zr, Ba, Ce, Nd, Eu). We found a mean iron content of [Fe/H] = -0.47 ± 0.02 (error on the mean). We confirm the existence of MPs in this GC with an O-Na anti-correlation, and moderate spread in Al abundances. We estimate a mean [α/Fe] = 0.25 ± 0.08. Iron-peak elements show no significant spread. The [Ba/Eu] ratios indicate a predominant contribution from SNeII for the formation of the cluster.

Personal exposure to Black Carbon in transport microenvironments

NASA Astrophysics Data System (ADS)

Dons, Evi; Int Panis, Luc; Van Poppel, Martine; Theunis, Jan; Wets, Geert

2012-08-01

We evaluated personal exposure of 62 individuals to the air pollutant Black Carbon, using 13 portable aethalometers while keeping detailed records of their time-activity pattern and whereabouts. Concentrations encountered in transport are studied in depth and related to trip motives. The evaluation comprises more than 1500 trips with different transport modes. Measurements were spread over two seasons. Results show that 6% of the time is spent in transport, but it accounts for 21% of personal exposure to Black Carbon and approximately 30% of inhaled dose. Concentrations in transport were 2-5 times higher compared to concentrations encountered at home. Exposure was highest for car drivers, and car and bus passengers. Concentrations of Black Carbon were only half as much when traveling by bike or on foot; when incorporating breathing rates, dose was found to be twice as high for active modes. Lowest 'in transport' concentrations were measured in trains, but nevertheless these concentrations are double the concentrations measured at home. Two thirds of the trips are car trips, and those trips showed a large spread in concentrations. In-car concentrations are higher during peak hours compared to off-peak, and are elevated on weekdays compared to Saturdays and even more so on Sundays. These findings result in significantly higher exposure during car commute trips (motive 'Work'), and lower concentrations for trips with motive 'Social and leisure'. Because of the many factors influencing exposure in transport, travel time is not a good predictor of integrated personal exposure or inhaled dose.

Seasonal spread and control of Bluetongue in cattle.

PubMed

Charron, Maud V P; Seegers, Henri; Langlais, Michel; Ezanno, Pauline

2011-12-21

Bluetongue is a seasonal midge-borne disease of ruminants with economic consequences on herd productivity and animal trade. Recently, two new modes of transmission have been demonstrated in cattle for Bluetongue virus serotype 8 (BTV8): vertical and pseudo-vertical transmission. Our objective was to model the seasonal spread of BTV8 over several years in a homogeneous population of cattle, and to evaluate the effectiveness of vaccination strategies. We built a deterministic mathematical model accounting for the seasonality in vector abundance and all the modes of transmission. We proposed a counterpart of the basic reproduction number (R(0)) in a seasonal context (R(S)). Set A(t) is the number of secondary cases produced by a primary case introduced at time t. R(S) is the average of A(t). It is a function of midge abundance and vaccination strategy. We also used A*, the maximum of A(t), as an indicator of the risk of an epidemic. Without vaccination, the model predicted a large first epidemic peak followed by smaller annual peaks if R(S)>1. When R(S)<1, small epidemics could occur if A* >1. Vaccination reduced R(S) and A* to less than one, but almost perfect vaccine efficacy and coverage were required to ensure no epidemics occurred. However, a lower coverage resulting in R(S)>1 could decrease infection prevalence. A further step would be to optimize vaccination strategies by targeting an appropriate period of the year to implement the vaccination. Copyright © 2011 Elsevier Ltd. All rights reserved.

Discharging dynamics in an electrolytic cell

NASA Astrophysics Data System (ADS)

Feicht, Sarah E.; Frankel, Alexandra E.; Khair, Aditya S.

2016-07-01

We analyze the dynamics of a discharging electrolytic cell comprised of a binary symmetric electrolyte between two planar, parallel blocking electrodes. When a voltage is initially applied, ions in the electrolyte migrate towards the electrodes, forming electrical double layers. After the system reaches steady state and the external current decays to zero, the applied voltage is switched off and the cell discharges, with the ions eventually returning to a uniform spatial concentration. At voltages on the order of the thermal voltage VT=kBT /q ≃25 mV, where kB is Boltzmann's constant, T is temperature, and q is the charge of a proton, experiments on surfactant-doped nonpolar fluids observe that the temporal evolution of the external current during charging and discharging is not symmetric [V. Novotny and M. A. Hopper, J. Electrochem. Soc. 126, 925 (1979), 10.1149/1.2129195; P. Kornilovitch and Y. Jeon, J. Appl. Phys. 109, 064509 (2011), 10.1063/1.3554445]. In fact, at sufficiently large voltages (several VT), the current during discharging is no longer monotonic: it displays a "reverse peak" before decaying in magnitude to zero. We analyze the dynamics of discharging by solving the Poisson-Nernst-Planck equations governing ion transport via asymptotic and numerical techniques in three regimes. First, in the "linear regime" when the applied voltage V is formally much less than VT, the charging and discharging currents are antisymmetric in time; however, the potential and charge density profiles during charging and discharging are asymmetric. The current evolution is on the R C timescale of the cell, λDL /D , where L is the width of the cell, D is the diffusivity of ions, and λD is the Debye length. Second, in the (experimentally relevant) thin-double-layer limit ɛ =λD/L ≪1 , there is a "weakly nonlinear" regime defined by VT≲V ≲VTln(1 /ɛ ) , where the bulk salt concentration is uniform; thus the R C timescale of the evolution of the current magnitude persists. However, nonlinear, voltage-dependent, capacitance of the double layer is responsible for a break in temporal antisymmetry of the charging and discharging currents. Third, the reverse peak in the discharging current develops in a "strongly nonlinear" regime V ≳VTln(1 /ɛ ) , driven by neutral salt adsorption into the double layers and consequent bulk depletion during charging. The strongly nonlinear regime features current evolution over three timescales. The current decays in magnitude on the double layer relaxation timescale, λD2/D ; then grows exponentially in time towards the reverse peak on the diffusion timescale, L2/D , indicating that the reverse peak is the results of fast diffusion of ions from the double layer layer to the bulk. Following the reverse peak, the current decays exponentially to zero on the R C timescale. Notably, the current at the reverse peak and the time of the reverse peak saturate at large voltages V ≫VTln(1 /ɛ ) . We provide semi-analytic expressions for the saturated reverse peak time and current, which can be used to infer charge carrier diffusivity and concentration from experiments.

Transmission dynamics of the 2009 influenza A (H1N1) pandemic in India: The impact of holiday-related school closure

PubMed Central

Taslim Ali, Sheikh; Kadi, A. S.; Ferguson, Neil M.

2014-01-01

The role of social-distancing measures, such as school closures, is a controversial aspect of pandemic mitigation planning. However, the timing of 2009 pandemic provides a natural experiment for evaluating the impact of school closure during holidays on influenza transmission. To quantify the transmission intensity of the influenza A (H1N1) pdm’09 in India, by estimating the time varying reproduction number (Rt) and correlating the temporal changes in the estimates of Rt for different regions of India with the timing of school holidays. We used daily lab-confirmed case reports of influenza A (H1N1) pdm’09 in India (during 17 May’09 to 17 May’10), stratified by regions. We estimated the transmissibility of the pandemic for different regions from these time-series, using Bayesian methods applied to a branching process model of disease spread and correlated the resulting estimates with the timing of school holidays in each region. The North-west region experienced two notable waves, with the peak of the first wave coinciding with the start of a 4 week school holiday (September-October’09). In the southern region the two waves were less clear cut, though again the first peak of the first wave coincided with the start of school holidays – albeit of less than 2 weeks duration (August’09). Our analysis suggests that the school holidays had a significant influence on the epidemiology of the 2009 pandemic in India. We estimate that school holidays reduced the reproduction number by 14%–27% in different regions of India, relative to levels seen outside holiday periods. The estimates of the reproduction number obtained (with peak R values below 1.5) are compatible with those reported from other regions of the world. This work reinforces past studies showing the significant impact of school holidays on spread of 2009 pandemic virus, and by inference the role of contact patterns in children on transmission. PMID:24267871

Spread F in the Midlatitude Ionosphere According to DPS-4 Ionosonde Data

NASA Astrophysics Data System (ADS)

Panchenko, V. A.; Telegin, V. A.; Vorob'ev, V. G.; Zhbankov, G. A.; Yagodkina, O. I.; Rozhdestvenskaya, V. I.

2018-03-01

The results of studying spread F obtained from the DPS-4 ionosonde data at the observatory of the Pushkov Institute of Terrestrial Magnetism, Ionosphere, and Radio Wave Propagation (Moscow) are presented. The methodical questions that arise during the study of a spread F phenomenon in the ionosphere are considered; the current results of terrestrial observations are compared with previously published data and the results of sounding onboard an Earth-satellite vehicle. The automated algorithm for estimation of the intensity of frequency spread F, which was developed by the authors and was successfully verified via comparison of the data of the digisonde DPS-4 and the results of manual processing, is described. The algorithm makes it possible to quantify the intensity of spread F in megahertz (the dFs parameter) and in the number of points (0, 1, 2, 3). The strongest spread (3 points) is shown to be most likely around midnight, while the weakest spread (0 points) is highly likely to occur during the daytime. The diurnal distribution of a 1-2 point spread F in the winter indicates the presence of additional maxima at 0300-0600 UT and 1400-1700 UT, which may appear due to the terminator. Despite the large volume of processed data, we can not definitively state that the appearance of spread F depends on the magnetic activity indices Kp, Dst, and AL, although the values of the dFs frequency spread interval strongly increased both at day and night during the magnetic storm of March 17-22, 2015, especially in the phase of storm recovery on March 20-22.

An intraorganizational model for developing and spreading quality improvement innovations.

PubMed

Kellogg, Katherine C; Gainer, Lindsay A; Allen, Adrienne S; OʼSullivan, Tatum; Singer, Sara J

Recent policy reforms encourage quality improvement (QI) innovations in primary care, but practitioners lack clear guidance regarding spread inside organizations. We designed this study to identify how large organizations can facilitate intraorganizational spread of QI innovations. We conducted ethnographic observation and interviews in a large, multispecialty, community-based medical group that implemented three QI innovations across 10 primary care sites using a new method for intraorganizational process development and spread. We compared quantitative outcomes achieved through the group's traditional versus new method, created a process model describing the steps in the new method, and identified barriers and facilitators at each step. The medical group achieved substantial improvement using its new method of intraorganizational process development and spread of QI innovations: standard work for rooming and depression screening, vaccine error rates and order compliance, and Pap smear error rates. Our model details nine critical steps for successful intraorganizational process development (set priorities, assess the current state, develop the new process, and measure and refine) and spread (develop support, disseminate information, facilitate peer-to-peer training, reinforce, and learn and adapt). Our results highlight the importance of utilizing preexisting organizational structures such as established communication channels, standardized roles, common workflows, formal authority, and performance measurement and feedback systems when developing and spreading QI processes inside an organization. In particular, we detail how formal process advocate positions in each site for each role can facilitate the spread of new processes. Successful intraorganizational spread is possible and sustainable. Developing and spreading new QI processes across sites inside an organization requires creating a shared understanding of the necessary process steps, considering the barriers that may arise at each step, and leveraging preexisting organizational structures to facilitate intraorganizational process development and spread.

An intraorganizational model for developing and spreading quality improvement innovations

PubMed Central

Kellogg, Katherine C.; Gainer, Lindsay A.; Allen, Adrienne S.; O'Sullivan, Tatum; Singer, Sara J.

2017-01-01

Background: Recent policy reforms encourage quality improvement (QI) innovations in primary care, but practitioners lack clear guidance regarding spread inside organizations. Purpose: We designed this study to identify how large organizations can facilitate intraorganizational spread of QI innovations. Methodology/Approach: We conducted ethnographic observation and interviews in a large, multispecialty, community-based medical group that implemented three QI innovations across 10 primary care sites using a new method for intraorganizational process development and spread. We compared quantitative outcomes achieved through the group’s traditional versus new method, created a process model describing the steps in the new method, and identified barriers and facilitators at each step. Findings: The medical group achieved substantial improvement using its new method of intraorganizational process development and spread of QI innovations: standard work for rooming and depression screening, vaccine error rates and order compliance, and Pap smear error rates. Our model details nine critical steps for successful intraorganizational process development (set priorities, assess the current state, develop the new process, and measure and refine) and spread (develop support, disseminate information, facilitate peer-to-peer training, reinforce, and learn and adapt). Our results highlight the importance of utilizing preexisting organizational structures such as established communication channels, standardized roles, common workflows, formal authority, and performance measurement and feedback systems when developing and spreading QI processes inside an organization. In particular, we detail how formal process advocate positions in each site for each role can facilitate the spread of new processes. Practice Implications: Successful intraorganizational spread is possible and sustainable. Developing and spreading new QI processes across sites inside an organization requires creating a shared understanding of the necessary process steps, considering the barriers that may arise at each step, and leveraging preexisting organizational structures to facilitate intraorganizational process development and spread. PMID:27428788

Beam-energy-spread minimization using cell-timing optimization

NASA Astrophysics Data System (ADS)

Rose, C. R.; Ekdahl, C.; Schulze, M.

2012-04-01

Beam energy spread, and related beam motion, increase the difficulty in tuning for multipulse radiographic experiments at the dual-axis radiographic hydrodynamic test facility’s axis-II linear induction accelerator (LIA). In this article, we describe an optimization method to reduce the energy spread by adjusting the timing of the cell voltages (both unloaded and loaded), either advancing or retarding, such that the injector voltage and summed cell voltages in the LIA result in a flatter energy profile. We developed a nonlinear optimization routine which accepts as inputs the 74 cell-voltage, injector voltage, and beam current waveforms. It optimizes cell timing per user-selected groups of cells and outputs timing adjustments, one for each of the selected groups. To verify the theory, we acquired and present data for both unloaded and loaded cell-timing optimizations. For the unloaded cells, the preoptimization baseline energy spread was reduced by 34% and 31% for two shots as compared to baseline. For the loaded-cell case, the measured energy spread was reduced by 49% compared to baseline.

Smearing of mass accretion rate variation by viscous processes in accretion disks in compact binary systems

NASA Astrophysics Data System (ADS)

Ghosh, A.; Chakrabarti, Sandip K.

2016-09-01

Variation of mass supply rate from the companion can be smeared out by viscous processes inside an accretion disk. Hence, by the time the flow reaches the inner edge, the variation in X-rays need not reflect the true variation of the mass supply rate at the outer edge. However, if the viscosity fluctuates around a mean value, one would expect the viscous time scale t_{{visc}} also to spread around a mean value. In high mass X-ray binaries, which are thought to be primarily wind-fed, the size of the viscous Keplerian disk is smaller and thus such a spread could be lower as compared to the low mass X-ray binaries which are primarily fed by Roche lobe overflow. If there is an increasing or decreasing trend in viscosity, the interval between enhanced emission would be modified systematically. In the absence of a detailed knowledge about the variation of mass supply rates at the outer edge, we study ideal circumstances where modulation must take place exactly in orbital time scales, such as when there is an ellipticity in the orbit. We study a few compact binaries using long term All Sky monitor (ASM) data (1.5-12 keV) of Rossi X-ray Timing Explorer (RXTE) and all sky survey data (15-50 keV) of Swift satellites by different methods to look for such smearing effects and to infer what these results can tell us about the viscous processes inside the respective disks. We employ three different methods to seek imprints of periodicity on the X-ray variation and found that in all the cases, the location of the peak in the power density spectra is consistent with the orbital frequencies. Interestingly, in high mass X-ray binaries the peaks are sharp with high rms values, consistent with a small Keplerian disk in a wind fed system. However, in low mass X-ray binaries with larger Keplerian disk component, the peaks are spreaded out with much lower rms values. X-ray reflections, or superhump phenomena which may also cause such X-ray modulations would not be affected by the size of the Keplerian disk component. Our result thus confirms different sizes of Keplerian disks in these two important classes of binaries. If the orbital periods of any binary system is not known, they may be obtained with reasonable accuracy for HMXBs and with lesser accuracy for LMXBs by our method.

A Review of the Role of Food and the Food System in the Transmission and Spread of Ebolavirus

PubMed Central

Mann, Erin; Streng, Stephen; Bergeron, Justin; Kircher, Amy

2015-01-01

The current outbreak of Ebola virus disease (EVD) centered in West Africa is the largest in history, with nearly ten times more individuals contracting the disease than all previous outbreaks combined. The details of human-to-human and zoonotic ebolavirus transmission have justifiably received the largest share of research attention, and much information exists on these topics. However, although food processing—in the form of slaughtering and preparing wildlife for consumption (referred to as bushmeat)—has been implicated in EVD outbreaks, the full role of food in EVD spread is poorly understood and has been little studied. A literature search was undertaken to assess the current state of knowledge regarding how food can or may transmit ebolaviruses and how the food system contributes to EVD outbreak and spread. The literature reveals surprising preliminary evidence that food and the food system may be more implicated in ebolavirus transmission than expected and that further research is urgently needed. PMID:26633305

Effects of individual popularity on information spreading in complex networks

NASA Astrophysics Data System (ADS)

Gao, Lei; Li, Ruiqi; Shu, Panpan; Wang, Wei; Gao, Hui; Cai, Shimin

2018-01-01

In real world, human activities often exhibit preferential selection mechanism based on the popularity of individuals. However, this mechanism is seldom taken into account by previous studies about spreading dynamics on networks. Thus in this work, an information spreading model is proposed by considering the preferential selection based on individuals' current popularity, which is defined as the number of individuals' cumulative contacts with informed neighbors. A mean-field theory is developed to analyze the spreading model. Through systematically studying the information spreading dynamics on uncorrelated configuration networks as well as real-world networks, we find that the popularity preference has great impacts on the information spreading. On the one hand, the information spreading is facilitated, i.e., a larger final prevalence of information and a smaller outbreak threshold, if nodes with low popularity are preferentially selected. In this situation, the effective contacts between informed nodes and susceptible nodes are increased, and nodes almost have uniform probabilities of obtaining the information. On the other hand, if nodes with high popularity are preferentially selected, the final prevalence of information is reduced, the outbreak threshold is increased, and even the information cannot outbreak. In addition, the heterogeneity of the degree distribution and the structure of real-world networks do not qualitatively affect the results. Our research can provide some theoretical supports for the promotion of spreading such as information, health related behaviors, and new products, etc.

Transport And Chemical Effects On Concurrent And Opposed-Flow Flame Spread At Microgravity

NASA Technical Reports Server (NTRS)

Son, Y.; Zouein, G.; Ronney, P. D.; Gokoglu, S.

2003-01-01

Flame spread over flat solid fuel beds is a useful means of understanding more complex two-phase non-premixed spreading flames, such as those that may occur due to accidents in inhabited buildings and orbiting spacecraft. The role of buoyant convection on flame spread is substantial, especially for thermally-thick fuels. With suitable assumptions, deRis showed that the spread rate (S(sub f)) is proportional to the buoyant or forced convection velocity (U) and thus suggests that S(sub f) is indeterminate at mu g (since S(sub f) = U) unless a forced flow is applied. (In contrast, for thermally thin fuels, the ideal S(sub f) is independent of U.) The conventional view, as supported by computations and space experiments, is that for quiescent g conditions, S(sub f) must be unsteady and decreasing until extinction occurs due to radiative losses. However, this view does not consider that radiative transfer to the fuel surface can enhance flame spread. In recent work we have found evidence that radiative transfer from the flame itself can lead to steady flame spread at mu g over thick fuel beds. Our current work focuses on refining these experiments and a companion modeling effort toward the goal of a space flight experiment called Radiative Enhancement Effects on Flame Spread (REEFS) planned for the International Space Station (ISS) c. 2007.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stoltzfus-Dueck, T.; Scott, B.

An often-neglected portion of the radialmore » $$\\boldsymbol{E}\\times \\boldsymbol{B}$$ drift is shown to drive an outward flux of co-current momentum when free energy is transferred from the electrostatic potential to ion parallel flows. This symmetry breaking is fully nonlinear, not quasilinear, necessitated simply by free-energy balance in parameter regimes for which significant energy is dissipated via ion parallel flows. The resulting rotation peaking is counter-current and has a scaling and order of magnitude that are comparable with experimental observations. Finally, the residual stress becomes inactive when frequencies are much higher than the ion transit frequency, which may explain the observed relation of density peaking and counter-current rotation peaking in the core.« less

Plant Invasions in China – Challenges and Chances

PubMed Central

Axmacher, Jan C.; Sang, Weiguo

2013-01-01

Invasive species cause serious environmental and economic harm and threaten global biodiversity. We set out to investigate how quickly invasive plant species are currently spreading in China and how their resulting distribution patterns are linked to socio-economic and environmental conditions. A comparison of the invasive plant species density (log species/log area) reported in 2008 with current data shows that invasive species were originally highly concentrated in the wealthy, southeastern coastal provinces of China, but they are currently rapidly spreading inland. Linear regression models based on the species density and turnover of invasive plants as dependent parameters and principal components representing key socio-economic and environmental parameters as predictors indicate strong positive links between invasive plant density and the overall phytodiversity and associated climatic parameters. Principal components representing socio-economic factors and endemic plant density also show significant positive links with invasive plant density. Urgent control and eradication measures are needed in China's coastal provinces to counteract the rapid inland spread of invasive plants. Strict controls of imports through seaports need to be accompanied by similarly strict controls of the developing horticultural trade and underpinned by awareness campaigns for China's increasingly affluent population to limit the arrival of new invaders. Furthermore, China needs to fully utilize its substantial native phytodiversity, rather than relying on exotics, in current large-scale afforestation projects and in the creation of urban green spaces. PMID:23691164

Modelling the electric field and the current density generated by cerebellar transcranial DC stimulation in humans.

PubMed

Parazzini, Marta; Rossi, Elena; Ferrucci, Roberta; Liorni, Ilaria; Priori, Alberto; Ravazzani, Paolo

2014-03-01

Transcranial Direct Current Stimulation (tDCS) over the cerebellum (or cerebellar tDCS) modulates working memory, changes cerebello-brain interaction, and affects locomotion in humans. Also, the use of tDCS has been proposed for the treatment of disorders characterized by cerebellar dysfunction. Nonetheless, the electric field (E) and current density (J) spatial distributions generated by cerebellar tDCS are unknown. This work aimed to estimate E and J distributions during cerebellar tDCS. Computational electromagnetics techniques were applied in three human realistic models of different ages and gender. The stronger E and J occurred mainly in the cerebellar cortex, with some spread (up to 4%) toward the occipital cortex. Also, changes by ±1cm in the position of the active electrode resulted in a small effect (up to 4%) in the E and J spatial distribution in the cerebellum. Finally, the E and J spreads to the brainstem and the heart were negligible, thus further supporting the safety of this technique. Despite inter-individual differences, our modeling study confirms that the cerebellum is the structure mainly involved by cerebellar tDCS. Modeling approach reveals that during cerebellar tDCS the current spread to other structures outside the cerebellum is unlike to produce functional effects. Copyright © 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Host and pathogen ecology drive the seasonal dynamics of a fungal disease, white-nose syndrome.

PubMed

Langwig, Kate E; Frick, Winifred F; Reynolds, Rick; Parise, Katy L; Drees, Kevin P; Hoyt, Joseph R; Cheng, Tina L; Kunz, Thomas H; Foster, Jeffrey T; Kilpatrick, A Marm

2015-01-22

Seasonal patterns in pathogen transmission can influence the impact of disease on populations and the speed of spatial spread. Increases in host contact rates or births drive seasonal epidemics in some systems, but other factors may occasionally override these influences. White-nose syndrome, caused by the emerging fungal pathogen Pseudogymnoascus destructans, is spreading across North America and threatens several bat species with extinction. We examined patterns and drivers of seasonal transmission of P. destructans by measuring infection prevalence and pathogen loads in six bat species at 30 sites across the eastern United States. Bats became transiently infected in autumn, and transmission spiked in early winter when bats began hibernating. Nearly all bats in six species became infected by late winter when infection intensity peaked. In summer, despite high contact rates and a birth pulse, most bats cleared infections and prevalence dropped to zero. These data suggest the dominant driver of seasonal transmission dynamics was a change in host physiology, specifically hibernation. Our study is the first, to the best of our knowledge, to describe the seasonality of transmission in this emerging wildlife disease. The timing of infection and fungal growth resulted in maximal population impacts, but only moderate rates of spatial spread. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

Host and pathogen ecology drive the seasonal dynamics of a fungal disease, white-nose syndrome

PubMed Central

Langwig, Kate E.; Frick, Winifred F.; Reynolds, Rick; Parise, Katy L.; Drees, Kevin P.; Hoyt, Joseph R.; Cheng, Tina L.; Kunz, Thomas H.; Foster, Jeffrey T.; Kilpatrick, A. Marm

2015-01-01

Seasonal patterns in pathogen transmission can influence the impact of disease on populations and the speed of spatial spread. Increases in host contact rates or births drive seasonal epidemics in some systems, but other factors may occasionally override these influences. White-nose syndrome, caused by the emerging fungal pathogen Pseudogymnoascus destructans, is spreading across North America and threatens several bat species with extinction. We examined patterns and drivers of seasonal transmission of P. destructans by measuring infection prevalence and pathogen loads in six bat species at 30 sites across the eastern United States. Bats became transiently infected in autumn, and transmission spiked in early winter when bats began hibernating. Nearly all bats in six species became infected by late winter when infection intensity peaked. In summer, despite high contact rates and a birth pulse, most bats cleared infections and prevalence dropped to zero. These data suggest the dominant driver of seasonal transmission dynamics was a change in host physiology, specifically hibernation. Our study is the first, to the best of our knowledge, to describe the seasonality of transmission in this emerging wildlife disease. The timing of infection and fungal growth resulted in maximal population impacts, but only moderate rates of spatial spread. PMID:25473016

On the instability of wave-fields with JONSWAP spectra to inhomogeneous disturbances, and the consequent long-time evolution

NASA Astrophysics Data System (ADS)

Ribal, A.; Stiassnie, M.; Babanin, A.; Young, I.

2012-04-01

The instability of two-dimensional wave-fields and its subsequent evolution in time are studied by means of the Alber equation for narrow-banded random surface-waves in deep water subject to inhomogeneous disturbances. A linear partial differential equation (PDE) is obtained after applying an inhomogeneous disturbance to the Alber's equation and based on the solution of this PDE, the instability of the ocean wave surface is studied for a JONSWAP spectrum, which is a realistic ocean spectrum with variable directional spreading and steepness. The steepness of the JONSWAP spectrum depends on γ and α which are the peak-enhancement factor and energy scale of the spectrum respectively and it is found that instability depends on the directional spreading, α and γ. Specifically, if the instability stops due to the directional spreading, increase of the steepness by increasing α or γ can reactivate it. This result is in qualitative agreement with the recent large-scale experiment and new theoretical results. In the instability area of α-γ plane, a long-time evolution has been simulated by integrating Alber's equation numerically and recurrent evolution is obtained which is the stochastic counterpart of the Fermi-Pasta-Ulam recurrence obtained for the cubic Schrödinger equation.

The bactericidal effect of shock waves

NASA Astrophysics Data System (ADS)

Leighs, J. A.; Appleby-Thomas, G. J.; Wood, D. C.; Goff, M. J.; Hameed, A.; Hazell, P. J.

2014-05-01

There are a variety of theories relating to the origins of life on our home planet, some of which discuss the possibility that life may have been spread via inter-planetary bodies. There have been a number of investigations into the ability of life to withstand the likely conditions generated by asteroid impact (both contained in the impactor and buried beneath the planet surface). Previously published data regarding the ability of bacteria to survive such applied shockwaves has produced conflicting conclusions. The work presented here used an established and published technique in combination with a single stage gas gun, to shock and subsequently recover Escherichia coli populations suspended in a phosphate buffered saline solution. Peak pressure across the sample region was calculated via numerical modelling. Survival data against peak sample pressure for recovered samples is presented alongside control tests. SEM micrographs of shocked samples are presented alongside control sets to highlight key differences between cells in each case.

Spectral restoration in high resolution electron energy loss spectroscopy based on iterative semi-blind Lucy-Richardson algorithm applied to rutile surfaces

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lazzari, Rémi, E-mail: remi.lazzari@insp.jussieu.fr; Li, Jingfeng, E-mail: jingfeng.li@insp.jussieu.fr; Jupille, Jacques, E-mail: jacques.jupille@insp.jussieu.fr

2015-01-15

A new spectral restoration algorithm of reflection electron energy loss spectra is proposed. It is based on the maximum likelihood principle as implemented in the iterative Lucy-Richardson approach. Resolution is enhanced and point spread function recovered in a semi-blind way by forcing cyclically the zero loss to converge towards a Dirac peak. Synthetic phonon spectra of TiO{sub 2} are used as a test bed to discuss resolution enhancement, convergence benefit, stability towards noise, and apparatus function recovery. Attention is focused on the interplay between spectral restoration and quasi-elastic broadening due to free carriers. A resolution enhancement by a factor upmore » to 6 on the elastic peak width can be obtained on experimental spectra of TiO{sub 2}(110) and helps revealing mixed phonon/plasmon excitations.« less

Error analysis of the Golay3 optical imaging system.

PubMed

Wu, Quanying; Fan, Junliu; Wu, Feng; Zhao, Jun; Qian, Lin

2013-05-01

We use aberration theory to derive a generalized pupil function of the Golay3 imaging system when astigmatisms exist in its submirrors. Theoretical analysis and numerical simulation using ZEMAX show that the point spread function (PSF) and the modulation transfer function (MTF) of the Golay3 sparse aperture system have a periodic change when there are piston errors. When the peak-valley value of the wavefront (PV(tilt)) due to the tilt error increases from zero to λ, the PSF and the MTF change significantly, and the change direction is determined by the location of the submirror with the tilt error. When PV(tilt) becomes larger than λ, the PSF and the MTF remain unvaried. We calculate the peaks of the signal-to-noise ratio (PSNR) resulting from the piston and tilt errors according to the Strehl ratio, and show that the PSNR decreases when the errors increase.

Maintenance of in vivo induced cytochrome P-450s in hepatocyte monolayers at non freezing temperatures.

PubMed

Evans, Peter J

2015-04-01

Cytochrome P450s (CYPs) induced in rats by 3-methylcholanthrene (3-MC), phenobarbital (PB) and dexamethasone (Dex) were investigated. The inducers had no effect on hepatocyte yield, viability, attachment or spreading on collagen. 3-MC induced ethoxyresorufin deethylase (EROD). Under normothermic conditions the activity fell in culture. However, it was maintained when cells were preserved at 10°C under a gelatin gel. Upon reactivation the activity mirrored that of freshly isolated cells at 37°C. Induced levels were stable for at least 6h , the time to form a confluent monolayer. The investigation was extended to other CYPs by looking at patterns of testosterone metabolism. Phenobarbital had the greatest influence in terms of the quantity and number of metabolites. Culture at 37°C decreased the peaks dramatically within 24 h. All 7 peaks were maintained in the preservation system. Copyright © 2015 Elsevier Inc. All rights reserved.

Magnitude and frequency of summer floods in western New Mexico and eastern Arizona

USGS Publications Warehouse

Kennon, F.W.

1955-01-01

Numerous small reservoirs and occasional water-spreading structures are being built on the ephemeral streams draining the public and Indian lands of the Southwest as part of the Soil and Moisture Conservation Program of the Bureau of Land Management and Bureau of Indian Affairs.  Economic design of these structures requires some knowledge of the flood rates and volumes.  Information concerning flood frequencies on areas less than 100 square miles is deficient throughout the country, particularly on intermittent streams of the Southwest.  Design engineers require a knowledge of the frequency and magnitude of flood volumes for the planning of adequate reservoir capacities and a knowledge of frequency and magnitude of flood peaks for spillway design.  Hence, this study deals with both flood volumes and peaks, the same statistical methods being used to develop frequency curves for each.

Forecasting seasonal outbreaks of influenza.

PubMed

Shaman, Jeffrey; Karspeck, Alicia

2012-12-11

Influenza recurs seasonally in temperate regions of the world; however, our ability to predict the timing, duration, and magnitude of local seasonal outbreaks of influenza remains limited. Here we develop a framework for initializing real-time forecasts of seasonal influenza outbreaks, using a data assimilation technique commonly applied in numerical weather prediction. The availability of real-time, web-based estimates of local influenza infection rates makes this type of quantitative forecasting possible. Retrospective ensemble forecasts are generated on a weekly basis following assimilation of these web-based estimates for the 2003-2008 influenza seasons in New York City. The findings indicate that real-time skillful predictions of peak timing can be made more than 7 wk in advance of the actual peak. In addition, confidence in those predictions can be inferred from the spread of the forecast ensemble. This work represents an initial step in the development of a statistically rigorous system for real-time forecast of seasonal influenza.

Forecasting seasonal outbreaks of influenza

PubMed Central

Shaman, Jeffrey; Karspeck, Alicia

2012-01-01

Influenza recurs seasonally in temperate regions of the world; however, our ability to predict the timing, duration, and magnitude of local seasonal outbreaks of influenza remains limited. Here we develop a framework for initializing real-time forecasts of seasonal influenza outbreaks, using a data assimilation technique commonly applied in numerical weather prediction. The availability of real-time, web-based estimates of local influenza infection rates makes this type of quantitative forecasting possible. Retrospective ensemble forecasts are generated on a weekly basis following assimilation of these web-based estimates for the 2003–2008 influenza seasons in New York City. The findings indicate that real-time skillful predictions of peak timing can be made more than 7 wk in advance of the actual peak. In addition, confidence in those predictions can be inferred from the spread of the forecast ensemble. This work represents an initial step in the development of a statistically rigorous system for real-time forecast of seasonal influenza. PMID:23184969

Weighting for sex acts to understand the spread of STI on networks.

PubMed

Moslonka-Lefebvre, Mathieu; Bonhoeffer, Sebastian; Alizon, Samuel

2012-10-21

Human sexual networks exhibit a heterogeneous structure where few individuals have many partners and many individuals have few partners. Network theory predicts that the spread of sexually transmitted infections (STI) on such networks should exhibit striking properties (e.g. rapid spread). However, these properties cannot be found in epidemiological data. Current network models typically assume a constant STI transmission risk per partnership, which is unrealistic because it implies that sexual activity is proportional to the number of partners and that individuals have the same activity with each partner. We develop a framework that allows us to weight any sexual network based on biological assumptions. Our results indicate that STI spreading on the resulting weighted networks do not have heterogeneous-related properties, which is consistent with data and earlier studies. Copyright © 2012 Elsevier Ltd. All rights reserved.

Cannibalism amplifies the spread of vertically transmitted pathogens.

PubMed

Sadeh, Asaf; Rosenheim, Jay A

2016-08-01

Cannibalism is a widespread behavior. Abundant empirical evidence demonstrates that cannibals incur a risk of contracting pathogenic infections when they consume infected conspecifics. However, current theory suggests that cannibalism generally impedes disease spread, because each victim is usually consumed by a single cannibal, such that cannibalism does not function as a spreading process. Consequently, cannibalism cannot be the only mode of transmission of most parasites. We develop simple, but general epidemiological models to analyze the interaction of cannibalism and vertical transmission. We show that cannibalism increases the prevalence of vertically transmitted pathogens whenever the host population density is not solely regulated by cannibalism. This mechanism, combined with additional, recently published, theoretical mechanisms, presents a strong case for the role of cannibalism in the spread of infectious diseases across a wide range of parasite-host systems. © 2016 by the Ecological Society of America.

Study of spread spectrum multiple access systems for satellite communications with overlay on current services

NASA Technical Reports Server (NTRS)

Ha, Tri T.; Pratt, Timothy

1989-01-01

The feasibility of using spread spectrum techniques to provide a low-cost multiple access system for a very large number of low data terminals was investigated. Two applications of spread spectrum technology to very small aperture terminal (VSAT) satellite communication networks are presented. Two spread spectrum multiple access systems which use a form of noncoherent M-ary FSK (MFSK) as the primary modulation are described and the throughput analyzed. The analysis considers such factors as satellite power constraints and adjacent satellite interference. Also considered is the effect of on-board processing on the multiple access efficiency and the feasibility of overlaying low data rate spread spectrum signals on existing satellite traffic as a form of frequency reuse is investigated. The use of chirp is examined for spread spectrum communications. In a chirp communication system, each data bit is converted into one or more up or down sweeps of frequency, which spread the RF energy across a broad range of frequencies. Several different forms of chirp communication systems are considered, and a multiple-chirp coded system is proposed for overlay service. The mutual interference problem is examined in detail and a performance analysis undertaken for the case of a chirp data channel overlaid on a video channel.

Peak Weight and Height Velocity to Age 36 Months and Asthma Development: The Norwegian Mother and Child Cohort Study

PubMed Central

Magnus, Maria C.; Stigum, Hein; Håberg, Siri E.; Nafstad, Per; London, Stephanie J.; Nystad, Wenche

2015-01-01

Background The immediate postnatal period is the period of the fastest growth in the entire life span and a critical period for lung development. Therefore, it is interesting to examine the association between growth during this period and childhood respiratory disorders. Methods We examined the association of peak weight and height velocity to age 36 months with maternal report of current asthma at 36 months (n = 50,311), recurrent lower respiratory tract infections (LRTIs) by 36 months (n = 47,905) and current asthma at 7 years (n = 24,827) in the Norwegian Mother and Child Cohort Study. Peak weight and height velocity was calculated using the Reed1 model through multilevel mixed-effects linear regression. Multivariable log-binomial regression was used to calculate adjusted relative risks (adj.RR) and 95% confidence intervals (CI). We also conducted a sibling pair analysis using conditional logistic regression. Results Peak weight velocity was positively associated with current asthma at 36 months [adj.RR 1.22 (95%CI: 1.18, 1.26) per standard deviation (SD) increase], recurrent LRTIs by 36 months [adj.RR 1.14 (1.10, 1.19) per SD increase] and current asthma at 7 years [adj.RR 1.13 (95%CI: 1.07, 1.19) per SD increase]. Peak height velocity was not associated with any of the respiratory disorders. The positive association of peak weight velocity and asthma at 36 months remained in the sibling pair analysis. Conclusions Higher peak weight velocity, achieved during the immediate postnatal period, increased the risk of respiratory disorders. This might be explained by an influence on neonatal lung development, shared genetic/epigenetic mechanisms and/or environmental factors. PMID:25635872

Transport and fate of river waters under flood conditions and rim current influence: the Mississippi River test case

NASA Astrophysics Data System (ADS)

Kourafalou, Villy; Androulidakis, Yannis

2013-04-01

Large river plumes are a major supplier of freshwater, sediments and nutrients in coastal and shelf seas. Novel processes controlling the transport and fate of riverine waters (and associated materials) will be presented, under flood conditions and in the presence of complex topography, ambient shelf circulation and slope processes, controlled by the interaction with rim currents. The Mississippi River (MR) freshwater outflow is chosen as a test case, as a major circulation forcing mechanism for the Northern Gulf of Mexico and a unique river plume for the intense interactions with a large scale ocean current, namely the Loop Current branch of the Gulf Stream, and associated eddy field. The largest MR outflow in history (45,000 m3/sec in 2011) is compared with the second largest outflow in the last 8 years (41,000 m3/sec in 2008). Realistically forced simulations, based on the Hybrid Coordinate Ocean Model (HYCOM) with careful treatment of river plume dynamics and nested to a data assimilated, basin-wide model, reveal the synergistic effect of enhanced discharge, winds, stratification of ambient shelf waters and offshore circulation over the transport of plume waters. The investigation targets a broader understanding of the dynamics of large scale river plumes in general, and of the MR plume in particular. In addition, in situ observations from ship surveys and satellite chl-a data showed that the mathematical simulations with high temporal resolution river outflow input may reproduce adequately the buoyant waters spreading over the Northern Gulf of Mexico shelf and offshore areas. The fate of the river plume is strongly determined and affected by deep basin processes. The strong impacts of the Loop Current system (and its frontal eddies) on river plume evolution are of particular importance under conditions of increased offshore spreading, which is presumed under large discharge rates and can cause loss of riverine materials to the basin interior. Flood conditions can increase both downstream (westward) and upstream (eastward) spreading. The high outflow rates enhance the anticyclonic bulge, strengthen the downstream coastal current toward the western Louisiana-Texas shelf. The substantial eastward spreading over the eastern Mississippi-Alabama-Florida shelf was highly correlated with the Loop Current northward extension. On the contrary, cyclonic eddies east of the Delta effectively block the offshore eastward spreading of the plume and may keep the river waters away from the eastern shelf. We show that the proximity of eddies to the shelf break is a sufficient condition for shelf-to-offshore interaction, which is facilitated by the steep bottom topography near the Delta.

Design and fabrication of low power GaAs/AlAs resonant tunneling diodes

NASA Astrophysics Data System (ADS)

Md Zawawi, Mohamad Adzhar; Missous, Mohamed

2017-12-01

A very low peak voltage GaAs/AlAs resonant tunneling diode (RTD) grown by molecular beam epitaxy (MBE) has been studied in detail. Excellent growth control with atomic-layer precision resulted in a peak voltage of merely 0.28 V (0.53 V) in forward (reverse) direction. The peak current density in forward bias is around 15.4 kA/cm2 with variation of within 7%. As for reverse bias, the peak current density is around 22.8 kA/cm2 with 4% variation which implies excellent scalability. In this work, we have successfully demonstrated the fabrication of a GaAs/AlAs RTD by using a conventional optical lithography and chemical wet-etching with very low peak voltage suitable for application in low dc input power RTD-based sub-millimetre wave oscillators.

Experimental Investigation of the Performance of Image Registration and De-aliasing Algorithms

DTIC Science & Technology

2009-09-01

spread function In the literature these types of algorithms are sometimes hcluded under the broad umbrella of superresolution . However, in the current...We use one of these patterns to visually demonstrate successful de-aliasing 15. SUBJECT TERMS Image de-aliasing Superresolution Microscanning Image...undersampled point spread function. In the literature these types of algorithms are sometimes included under the broad umbrella of superresolution . However, in

Spreading Depolarizations Have Prolonged Direct Current Shifts and Are Associated with Poor Outcome in Brain Trauma

DTIC Science & Technology

2011-01-01

prognosis. Keywords: cortical spreading depression; electroencephalography; craniotomy ; signal processing; acute brain injury Introduction Cortical...Mannheim, Germany). Inclusion criteria were the clinical decision for craniotomy for lesion evacuation and/or decompression and age ~ 18 years...externalized through a burr hole in the skull (if the bone flap was replaced) and tu nne lied beneath the scalp to exit 2-3 em from the craniotomy

Rapid Spread of Zika Virus in The Americas--Implications for Public Health Preparedness for Mass Gatherings at the 2016 Brazil Olympic Games.

PubMed

Petersen, Eskild; Wilson, Mary E; Touch, Sok; McCloskey, Brian; Mwaba, Peter; Bates, Matthew; Dar, Osman; Mattes, Frank; Kidd, Mike; Ippolito, Giuseppe; Azhar, Esam I; Zumla, Alimuddin

2016-03-01

Mass gatherings at major international sporting events put millions of international travelers and local host-country residents at risk of acquiring infectious diseases, including locally endemic infectious diseases. The mosquito-borne Zika virus (ZIKV) has recently aroused global attention due to its rapid spread since its first detection in May 2015 in Brazil to 22 other countries and other territories in the Americas. The ZIKV outbreak in Brazil, has also been associated with a significant rise in the number of babies born with microcephaly and neurological disorders, and has been declared a 'Global Emergency by the World Health Organization. This explosive spread of ZIKV in Brazil poses challenges for public health preparedness and surveillance for the Olympics and Paralympics which are due to be held in Rio De Janeiro in August, 2016. We review the epidemiology and clinical features of the current ZIKV outbreak in Brazil, highlight knowledge gaps, and review the public health implications of the current ZIKV outbreak in the Americas. We highlight the urgent need for a coordinated collaborative response for prevention and spread of infectious diseases with epidemic potential at mass gatherings events. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

Improved test methods for determining lightning-induced voltages in aircraft

NASA Technical Reports Server (NTRS)

Crouch, K. E.; Plumer, J. A.

1980-01-01

A lumped parameter transmission line with a surge impedance matching that of the aircraft and its return lines was evaluated as a replacement for earlier current generators. Various test circuit parameters were evaluated using a 1/10 scale relative geometric model. Induced voltage response was evaluated by taking measurements on the NASA-Dryden Digital Fly by Wire F-8 aircraft. Return conductor arrangements as well as other circuit changes were also evaluated, with all induced voltage measurements being made on the same circuit for comparison purposes. The lumped parameter transmission line generates a concave front current wave with the peak di/dt near the peak of the current wave which is more representative of lightning. However, the induced voltage measurements when scaled by appropriate scale factors (peak current or di/dt) resulting from both techniques yield comparable results.

AC losses in (Bi,Pb) 2Sr 2Ca 2Cu 3O x tapes

NASA Astrophysics Data System (ADS)

D'Anna, G.; Indenbom, M. V.; André, M.-O.; Benoit, W.; Grivel, J.-C.; Hensel, B.; Flükiger, R.

1994-05-01

A double peak structure is observed in the AC losses of (Bi,Pb) 2Sr 2Ca 2Cu 3O x silver-sheathed tapes using a torsion-pendulum oscillator. The low-temperature peak is associated to the intragrain flux expulsion, while the high-temperature peak results from a macroscopic current path around the whole sample due to a well-coupled fraction of the grains. The flux pinning by the dislocations forming small-angle grain boundaries is suggested to control the transport current.

Digital processing with single electrons for arbitrary waveform generation of current

NASA Astrophysics Data System (ADS)

Okazaki, Yuma; Nakamura, Shuji; Onomitsu, Koji; Kaneko, Nobu-Hisa

2018-03-01

We demonstrate arbitrary waveform generation of current using a GaAs-based single-electron pump. In our experiment, a digital processing algorithm known as delta-sigma modulation is incorporated into single-electron pumping to generate a density-modulated single-electron stream, by which we demonstrate the generation of arbitrary waveforms of current including sinusoidal, square, and triangular waves with a peak-to-peak amplitude of approximately 10 pA and an output bandwidth ranging from dc to close to 1 MHz. The developed current generator can be used as the precise and calculable current reference required for measurements of current noise in low-temperature experiments.

Influence of emission threshold of explosive emission cathodes on current waveform in foilless diodes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wu, P.; Liu, G. Z.; Science and Technology on High Power Microwave Laboratory, Northwest Institute of Nuclear Technology, Xi'an 710024

The emission threshold of explosive emission cathodes (EECs) is an important factor for beam quality. It can affect the explosive emission delay time, the plasma expansion process on the cathode surface, and even the current amplitude when the current is not fully space-charge-limited. This paper researches the influence of the emission threshold of an annular EEC on the current waveform in a foilless diode when the current is measured by a Rogowski coil. The particle-in-cell simulation which is performed under some tolerable and necessary simplifications shows that the long explosive emission delay time of high-threshold cathodes may leave an apparentmore » peak of displacement current on the rise edge of the current waveform, and this will occur only when the electron emission starts after this peak. The experimental researches, which are performed under a diode voltage of 1 MV and a repetitive frequency of 20 Hz, demonstrate that the graphite cathode has a lower emission threshold and a longer lifetime than the stainless steel cathode according to the variation of the peak of displacement current on the rise edge of the current waveform.« less

A note on the revised galactic neutron spectrum of the Ames collaborative study

NASA Technical Reports Server (NTRS)

Schaefer, H. J.

1980-01-01

Energy distributions of the neutron dose equivalents in the 0.1 to 300 Mev interval for the Ames and Hess spectra are compared. The Ames spectrum shows no evaporation peak, moves the bulk of the flux away from the region of elastic collision and spreads it more evenly over higher energies. The neutron spectrum in space does not seem to hear out the Ames model. Emulsion findings on all manned missions of the past consistently indicate that evaporation events are a prolific source of neutrons in space.

From Relativistic Electrons to X-ray Phase Contrast Imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lumpkin, A. H.; Garson, A. B.; Anastasio, M. A.

2017-10-09

We report the initial demonstrations of the use of single crystals in indirect x-ray imaging for x-ray phase contrast imaging at the Washington University in St. Louis Computational Bioimaging Laboratory (CBL). Based on single Gaussian peak fits to the x-ray images, we observed a four times smaller system point spread function (21 μm (FWHM)) with the 25-mm diameter single crystals than the reference polycrystalline phosphor’s 80-μm value. Potential fiber-optic plate depth-of-focus aspects and 33-μm diameter carbon fiber imaging are also addressed.

Nanodosimetry-Based Plan Optimization for Particle Therapy

PubMed Central

Schulte, Reinhard W.

2015-01-01

Treatment planning for particle therapy is currently an active field of research due uncertainty in how to modify physical dose in order to create a uniform biological dose response in the target. A novel treatment plan optimization strategy based on measurable nanodosimetric quantities rather than biophysical models is proposed in this work. Simplified proton and carbon treatment plans were simulated in a water phantom to investigate the optimization feasibility. Track structures of the mixed radiation field produced at different depths in the target volume were simulated with Geant4-DNA and nanodosimetric descriptors were calculated. The fluences of the treatment field pencil beams were optimized in order to create a mixed field with equal nanodosimetric descriptors at each of the multiple positions in spread-out particle Bragg peaks. For both proton and carbon ion plans, a uniform spatial distribution of nanodosimetric descriptors could be obtained by optimizing opposing-field but not single-field plans. The results obtained indicate that uniform nanodosimetrically weighted plans, which may also be radiobiologically uniform, can be obtained with this approach. Future investigations need to demonstrate that this approach is also feasible for more complicated beam arrangements and that it leads to biologically uniform response in tumor cells and tissues. PMID:26167202

Ebola Virus Disease--Sierra Leone and Guinea, August 2015.

PubMed

Hersey, Sara; Martel, Lise D; Jambai, Amara; Keita, Sakoba; Yoti, Zabulon; Meyer, Erika; Seeman, Sara; Bennett, Sarah; Ratto, Jeffrey; Morgan, Oliver; Akyeampong, Mame Afua; Sainvil, Schabbethai; Worrell, Mary Claire; Fitter, David; Arnold, Kathryn E

2015-09-11

The Ebola virus disease (Ebola) outbreak in West Africa began in late 2013 in Guinea (1) and spread unchecked during early 2014. By mid-2014, it had become the first Ebola epidemic ever documented. Transmission was occurring in multiple districts of Guinea, Liberia, and Sierra Leone, and for the first time, in capital cities (2). On August 8, 2014, the World Health Organization (WHO) declared the outbreak to be a Public Health Emergency of International Concern (3). Ministries of Health, with assistance from multinational collaborators, have reduced Ebola transmission, and the number of cases is now declining. While Liberia has not reported a case since July 12, 2015, transmission has continued in Guinea and Sierra Leone, although the numbers of cases reported are at the lowest point in a year. In August 2015, Guinea and Sierra Leone reported 10 and four confirmed cases, respectively, compared with a peak of 526 (Guinea) and 1,997 (Sierra Leone) in November 2014. This report details the current situation in Guinea and Sierra Leone, outlines strategies to interrupt transmission, and highlights the need to maintain public health response capacity and vigilance for new cases at this critical time to end the outbreak.

Kinetic performance of narrow-bore columns on a micro-system for high performance liquid chromatography.

PubMed

Gritti, Fabrice; Guiochon, Georges

2012-05-04

The kinetic performance of 0.5 mm × 50 mm columns packed with 2.7 μm Halo-C(18) core-shell particles and 3 μm EP-120-C(18) fully porous particles fitted on an Eksigent LC-Express Ultra μHPLC system were measured. The instrument contribution to band broadening was obtained by directly connecting the injection valve and the detector cell with a short, narrow PEEKSIL tube. The connections between the column and the connecting tubes, the column endfittings and its frits contribute to band spreading and are responsible for a significant rear peak tailing, even for retained compounds, resulting in a significant loss of efficiency. Our results show that the μHPLC system could outperform the current VHPLC systems using 2.1mm I.D. columns packed with 1.7 μm particles if it were using 0.5mm I.D. columns packed with 1 μm particles, if it could operate at a few kbar pressure drop, and if the sum of the contributions of the instrument, column endfittings and the column frits to band dispersion were three times smaller than it is at present. Copyright © 2012 Elsevier B.V. All rights reserved.

Golden beam data for proton pencil-beam scanning.

PubMed

Clasie, Benjamin; Depauw, Nicolas; Fransen, Maurice; Gomà, Carles; Panahandeh, Hamid Reza; Seco, Joao; Flanz, Jacob B; Kooy, Hanne M

2012-03-07

Proton, as well as other ion, beams applied by electro-magnetic deflection in pencil-beam scanning (PBS) are minimally perturbed and thus can be quantified a priori by their fundamental interactions in a medium. This a priori quantification permits an optimal reduction of characterizing measurements on a particular PBS delivery system. The combination of a priori quantification and measurements will then suffice to fully describe the physical interactions necessary for treatment planning purposes. We consider, for proton beams, these interactions and derive a 'Golden' beam data set. The Golden beam data set quantifies the pristine Bragg peak depth-dose distribution in terms of primary, multiple Coulomb scatter, and secondary, nuclear scatter, components. The set reduces the required measurements on a PBS delivery system to the measurement of energy spread and initial phase space as a function of energy. The depth doses are described in absolute units of Gy(RBE) mm² Gp⁻¹, where Gp equals 10⁹ (giga) protons, thus providing a direct mapping from treatment planning parameters to integrated beam current. We used these Golden beam data on our PBS delivery systems and demonstrated that they yield absolute dosimetry well within clinical tolerance.

Ponzi scheme diffusion in complex networks

NASA Astrophysics Data System (ADS)

Zhu, Anding; Fu, Peihua; Zhang, Qinghe; Chen, Zhenyue

2017-08-01

Ponzi schemes taking the form of Internet-based financial schemes have been negatively affecting China's economy for the last two years. Because there is currently a lack of modeling research on Ponzi scheme diffusion within social networks yet, we develop a potential-investor-divestor (PID) model to investigate the diffusion dynamics of Ponzi scheme in both homogeneous and inhomogeneous networks. Our simulation study of artificial and real Facebook social networks shows that the structure of investor networks does indeed affect the characteristics of dynamics. Both the average degree of distribution and the power-law degree of distribution will reduce the spreading critical threshold and will speed up the rate of diffusion. A high speed of diffusion is the key to alleviating the interest burden and improving the financial outcomes for the Ponzi scheme operator. The zero-crossing point of fund flux function we introduce proves to be a feasible index for reflecting the fast-worsening situation of fiscal instability and predicting the forthcoming collapse. The faster the scheme diffuses, the higher a peak it will reach and the sooner it will collapse. We should keep a vigilant eye on the harm of Ponzi scheme diffusion through modern social networks.

Observations of unusual pre-dawn response of the equatorial F-region during geomagnetic disturbances

NASA Astrophysics Data System (ADS)

Lima, W.; Becker-Guedes, F.; Fagundes, P.; Sahai, Y.; Abalde, J.; Pillat, V.

It is known that the disturbed solar wind-magnetosphere interactions have important effects on equatorial and low-latitude ionospheric electrodynamics. The response of equatorial ionosphere during storm-time is an important aspect of space weather studies. It has been observed that during geomagnetic disturbances both suppression as well as generation of equatorial spread-F (ESF) or plasma irregularities takes place. However, the mechanism(s) associated with the generation of ESF still needs further investigations. This work reports some unusual events of pre-dawn occurrence of ionospheric F-region satellite traces followed by spread-F and cusp-like spread-F from ionospheric sounding observations carried out by a Canadian Advanced Digital Ionosonde (CADI) localized at Palmas (10.2°, 48.2°W, dip latitude 5.7°S), Brazil during 2002, every 5 minutes. For the present work we have scaled and analyzed the ionospheric sounding data for three events (April 20, September 04 and 08, 2002), which are associated with geomagnetic disturbances. In the events studied, the ionograms show the occurrence of satellite trace followed by cusp-like spread. The cusp like features move up in frequency and height and finally attain the F-layer peak value (foF2) and then disappear. They had duration of about 30 min and always occurred in the early morning hours. Our studies involved seven geomagnetic disturbances as well as quiet days during the year 2002, but only on these three occasions we observed these features. We present and discuss these observations in this paper and suggest possible mechanisms for the occurrence of these unusual features.

Lateral temperature spread of monopolar, bipolar and ultrasonic instruments for robot-assisted laparoscopic surgery.

PubMed

Hefermehl, Lukas J; Largo, Remo A; Hermanns, Thomas; Poyet, Cédric; Sulser, Tullio; Eberli, Daniel

2014-08-01

To assess critical heat spread of cautery instruments used in robot-assisted laparoscopic (RAL) surgery. Thermal spread along bovine musculofascial tissues was examined by infrared camera, histology and enzyme assay. Currently used monopolar, bipolar and ultrasonic laparoscopic instruments were investigated at various power settings and application times. The efficacy of using an additional Maryland clamp as a heat sink was evaluated. A temperature of 45 °C was considered the threshold temperature for possible nerve damage. Monopolar instruments exhibited a mean (sem) critical thermal spread of 3.5 (2.3) mm when applied at 60 W for 1 s. After 2 s, the spread was >20 mm. For adjustable bipolar instruments the mean (sem) critical thermal spread was 2.2 (0.6) mm at 60 W and 1 s, and 3.6 (1.3) mm at 2 s. The PK and LigaSure forceps had mean (sem) critical thermal spreads of 3.9 (0.8) and 2.8 (0.6) mm respectively, whereas the ultrasonic instrument reached 2.9 (0.8) mm. Application of an additional Maryland clamp as a heat sink, significantly reduced the thermal spread. Histomorphometric analyses and enzyme assay supported these findings. All coagulation devices used in RAL surgery have distinct thermal spreads depending on power setting and application time. Cautery may be of concern due to lateral temperature spread, causing potential damage to sensitive structures including nerves. Our results provide surgeons with a resource for educated decision-making when using coagulation devices during robotic procedures. © 2013 The Authors. BJU International © 2013 BJU International.

Verification of the tumor volume delineation method using a fixed threshold of peak standardized uptake value.

PubMed

Koyama, Kazuya; Mitsumoto, Takuya; Shiraishi, Takahiro; Tsuda, Keisuke; Nishiyama, Atsushi; Inoue, Kazumasa; Yoshikawa, Kyosan; Hatano, Kazuo; Kubota, Kazuo; Fukushi, Masahiro

2017-09-01

We aimed to determine the difference in tumor volume associated with the reconstruction model in positron-emission tomography (PET). To reduce the influence of the reconstruction model, we suggested a method to measure the tumor volume using the relative threshold method with a fixed threshold based on peak standardized uptake value (SUV peak ). The efficacy of our method was verified using 18 F-2-fluoro-2-deoxy-D-glucose PET/computed tomography images of 20 patients with lung cancer. The tumor volume was determined using the relative threshold method with a fixed threshold based on the SUV peak . The PET data were reconstructed using the ordered-subset expectation maximization (OSEM) model, the OSEM + time-of-flight (TOF) model, and the OSEM + TOF + point-spread function (PSF) model. The volume differences associated with the reconstruction algorithm (%VD) were compared. For comparison, the tumor volume was measured using the relative threshold method based on the maximum SUV (SUV max ). For the OSEM and TOF models, the mean %VD values were -0.06 ± 8.07 and -2.04 ± 4.23% for the fixed 40% threshold according to the SUV max and the SUV peak, respectively. The effect of our method in this case seemed to be minor. For the OSEM and PSF models, the mean %VD values were -20.41 ± 14.47 and -13.87 ± 6.59% for the fixed 40% threshold according to the SUV max and SUV peak , respectively. Our new method enabled the measurement of tumor volume with a fixed threshold and reduced the influence of the changes in tumor volume associated with the reconstruction model.

LETTER TO THE EDITOR: Evidence for global mixing in real influenza epidemics

NASA Astrophysics Data System (ADS)

Bonabeau, Eric; Toubiana, Laurent; Flahault, Antoine

1998-05-01

The spatiotemporal behaviour of the spread of influenza in France has been studied, and algebraic spatial correlations (with exponent 0305-4470/31/19/001/img5) spanning the whole territory have been found to be present as soon as the number of reported cases begins to increase, about 15 - 25 weeks before the peak of the epidemic. This result is surprising, as one would expect long-range correlations, if any, only in the vicinity of the maximum incidence, whereas our observations suggest that there exists an underlying non-trivial spatial structure at the very beginning of the observed epidemic. The observed long-range correlations are in fact present in the spatial distribution of the population. Correlations in the number of cases normalized by local population density are characterized by 0305-4470/31/19/001/img6. This suggests that the spread of the epidemic is statistically uniform in space over a complex substrate that already contains the observed long-range correlations.

Theoretical analysis of the performance of code division multiple access communications over multimode optical fiber channels. Part 1: Transmission and detection

NASA Astrophysics Data System (ADS)

Walker, Ernest L.

1994-05-01

This paper presents results of a theoretical investigation to evaluate the performance of code division multiple access communications over multimode optical fiber channels in an asynchronous, multiuser communication network environment. The system is evaluated using Gold sequences for spectral spreading of the baseband signal from each user employing direct-sequence biphase shift keying and intensity modulation techniques. The transmission channel model employed is a lossless linear system approximation of the field transfer function for the alpha -profile multimode optical fiber. Due to channel model complexity, a correlation receiver model employing a suboptimal receive filter was used in calculating the peak output signal at the ith receiver. In Part 1, the performance measures for the system, i.e., signal-to-noise ratio and bit error probability for the ith receiver, are derived as functions of channel characteristics, spectral spreading, number of active users, and the bit energy to noise (white) spectral density ratio. In Part 2, the overall system performance is evaluated.

Genomic Epidemiology Reconstructs the Introduction and Spread of Zika Virus in Central America and Mexico.

PubMed

Thézé, Julien; Li, Tony; du Plessis, Louis; Bouquet, Jerome; Kraemer, Moritz U G; Somasekar, Sneha; Yu, Guixia; de Cesare, Mariateresa; Balmaseda, Angel; Kuan, Guillermina; Harris, Eva; Wu, Chieh-Hsi; Ansari, M Azim; Bowden, Rory; Faria, Nuno R; Yagi, Shigeo; Messenger, Sharon; Brooks, Trevor; Stone, Mars; Bloch, Evan M; Busch, Michael; Muñoz-Medina, José E; González-Bonilla, Cesar R; Wolinsky, Steven; López, Susana; Arias, Carlos F; Bonsall, David; Chiu, Charles Y; Pybus, Oliver G

2018-06-13

The Zika virus (ZIKV) epidemic in the Americas established ZIKV as a major public health threat and uncovered its association with severe diseases, including microcephaly. However, genetic epidemiology in some at-risk regions, particularly Central America and Mexico, remains limited. We report 61 ZIKV genomes from this region, generated using metagenomic sequencing with ZIKV-specific enrichment, and combine phylogenetic, epidemiological, and environmental data to reconstruct ZIKV transmission. These analyses revealed multiple independent ZIKV introductions to Central America and Mexico. One introduction, likely from Brazil via Honduras, led to most infections and the undetected spread of ZIKV through the region from late 2014. Multiple lines of evidence indicate biannual peaks of ZIKV transmission in the region, likely driven by varying local environmental conditions for mosquito vectors and herd immunity. The spatial and temporal heterogeneity of ZIKV transmission in Central America and Mexico challenges arbovirus surveillance and disease control measures. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Sleeping sickness in Uganda: revisiting current and historical distributions.

PubMed

Berrang-Ford, Lea; Odiit, Martin; Maiso, Faustin; Waltner-Toews, David; McDermott, John

2006-12-01

Sleeping sickness is a parasitic, vector-borne disease, carried by the tsetse fly and prevalent in sub-Saharan Africa. The disease continues to pose a public health burden in Uganda, which experienced a widespread outbreak in 1900-1920, and a more recent outbreak in 1976-1989. The disease continues to spread to uninfected districts. This paper compares the spatial distributions of sleeping in Uganda for the 1900-1920 outbreak period with current disease foci, and discusses information gaps and implications arising for future research, prevention and control. Population census records for 1911 and sleeping sickness records from Medical and Sanitary Reports of the Ugandan Protectorate for 1905-1936 were extracted from the Uganda Archives. Current sleeping sickness distribution data were provided by the Ministry of Health, Uganda. These were used to develop sleeping sickness distribution maps for comparison between the early 1900s and the early 2000s. The distribution of sleeping sickness from 1905-1920 shows notable differences compared to the current distribution of disease. In particular, archival cases were recorded in south-west and central Uganda, areas currently free of disease. The disease focus has moved from lakeshore Buganda (1905-1920) to the Busoga and south-east districts. Archival sleeping sickness distributions indicate the potential for a much wider area of disease risk than indicated by current disease foci. This is compounded by an absence of tsetse distribution data, continued political instability in north-central Uganda, continued spread of disease into new districts, and evidence of the role of livestock movements in spreading the parasite. These results support concerns as to the potential mergence of the two disease foci in the south-east and north-west of the country.

Momentum flux parasitic to free-energy transfer

DOE PAGES

Stoltzfus-Dueck, T.; Scott, B.

2017-05-11

An often-neglected portion of the radialmore » $$\\boldsymbol{E}\\times \\boldsymbol{B}$$ drift is shown to drive an outward flux of co-current momentum when free energy is transferred from the electrostatic potential to ion parallel flows. This symmetry breaking is fully nonlinear, not quasilinear, necessitated simply by free-energy balance in parameter regimes for which significant energy is dissipated via ion parallel flows. The resulting rotation peaking is counter-current and has a scaling and order of magnitude that are comparable with experimental observations. Finally, the residual stress becomes inactive when frequencies are much higher than the ion transit frequency, which may explain the observed relation of density peaking and counter-current rotation peaking in the core.« less

Controlling the spread of carbapenemase-producing Gram-negatives: therapeutic approach and infection control.

PubMed

Carmeli, Y; Akova, M; Cornaglia, G; Daikos, G L; Garau, J; Harbarth, S; Rossolini, G M; Souli, M; Giamarellou, H

2010-02-01

Although the rapid spread of carbapenemase-producing Gram-negatives (CPGNs) is providing the scientific community with a great deal of information about the molecular epidemiology of these enzymes and their genetic background, data on how to treat multidrug-resistant or extended drug-resistant carbapenemase-producing Enterobacteriaceae and how to contain their spread are still surprisingly limited, in spite of the rapidly increasing prevalence of these organisms and of their isolation from patients suffering from life-threatening infections. Limited clinical experience and several in vitro synergy studies seem to support the view that antibiotic combinations should be preferred to monotherapies. But, in light of the data available to date, it is currently impossible to quantify the real advantage of drug combinations in the treatment of these infections. Comprehensive clinical studies of the main therapeutic options, broken down by pathogen, enzyme and clinical syndrome, are definitely lacking and, as carbapenemases keep spreading, are urgently needed. This spread is unveiling the substantial unpreparedness of European public health structures to face this worrisome emergency, although experiences from different countries-chiefly Greece and Israel-have shown that CPGN transmission and cross-infection can cause a substantial threat to the healthcare system. This unpreparedness also affects the treatment of individual patients and infection control policies, with dramatic scarcities of both therapeutic options and infection control measures. Although correct implementation of such measures is presumably cumbersome and expensive, the huge clinical and public health problems related to CPGN transmission, alongside the current scarcity of therapeutic options, seem to fully justify this choice.

Novel five-state latch using double-peak negative differential resistance and standard ternary inverter

NASA Astrophysics Data System (ADS)

Shin, Sunhae; Rok Kim, Kyung

2016-04-01

We propose complement double-peak negative differential resistance (NDR) devices with ultrahigh peak-to-valley current ratio (PVCR) over 106 by combining tunnel diode with conventional CMOS and its compact five-state latch circuit by introducing standard ternary inverter (STI). At the “high”-state of STI, n-type NDR device (tunnel diode with nMOS) has 1st NDR characteristics with 1st peak and valley by band-to-band tunneling (BTBT) and trap-assisted tunneling (TAT), whereas p-type NDR device (tunnel diode with pMOS) has second NDR characteristics from the suppression of diode current by off-state MOSFET. The “intermediate”-state of STI permits double-peak NDR device to operate five-state latch with only four transistors, which has 33% area reduction compared with that of binary inverter and 57% bit-density reduction compared with binary latch.

Ohia forest decline: its spread and severity in Hawaii

Treesearch

Edwin Q. P. Petteys; Robert E. Burgan; Robert E. Nelson

1975-01-01

Ohia forest decline–its severity and rate of spread–was studied by aerial photographic techniques on a 197,000-acre (80,000-ha) portion of the island of Hawaii. In 1954, only 300 acres (121 ha) showed signs of severe decline; by 1972, the acreage of severely affected forest had increased to 85,200 acres (34,480 ha). Rate of decline and current severity were related to...

Particle in cell simulation of peaking switch for breakdown evaluation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Umbarkar, Sachin B.; Bindu, S.; Mangalvedekar, H.A.

2014-07-01

Marx generator connected to peaking capacitor and peaking switch can generate Ultra-Wideband (UWB) radiation. A new peaking switch is designed for converting the existing nanosecond Marx generator to a UWB source. The paper explains the particle in cell (PIC) simulation for this peaking switch, using MAGIC 3D software. This peaking switch electrode is made up of copper tungsten material and is fixed inside the hermitically sealed derlin material. The switch can withstand a gas pressure up to 13.5 kg/cm{sup 2}. The lower electrode of the switch is connected to the last stage of the Marx generator. Initially Marx generator (withoutmore » peaking stage) in air; gives the output pulse with peak amplitude of 113.75 kV and pulse rise time of 25 ns. Thus, we design a new peaking switch to improve the rise time of output pulse and to pressurize this peaking switch separately (i.e. Marx and peaking switch is at different pressure). The PIC simulation gives the particle charge density, current density, E counter plot, emitted electron current, and particle energy along the axis of gap between electrodes. The charge injection and electric field dependence on ionic dissociation phenomenon are briefly analyzed using this simulation. The model is simulated with different gases (N{sub 2}, H{sub 2}, and Air) under different pressure (2 kg/cm{sup 2}, 5 kg/cm{sup 2}, 10 kg/cm{sup 2}). (author)« less

Anomalous hydrogen emissions from the San Andreas fault observed at the Cienega Winery, central California

NASA Astrophysics Data System (ADS)

Sato, Motoaki; Sutton, A. J.; McGee, K. A.

1984-03-01

We began continuous monitoring of H2 concentration in soil along the San Andreas and Calaveras faults in central California in December 1980, using small H2/O2 fuel-cell sensors. Ten monitoring stations deployed to date have shown that anomalous H2 emissions take place occasionally in addition to diurnal changes. Among the ten sites, the Cienega Winery site has produced data that are characterized by very small diurnal changes, a stable baseline, and remarkably distinct spike-like H2 anomalies since its installation in July 1982. A major peak appeared on 1 10 November 1982, and another on 3 April 1983, and a medium peak on 1 November 1983. The occurrences of these peaks coincided with periods of very low seismicity within a radius of 50 km from the site. In order to methodically assess how these peaks are related to earthquakes, three H2 degassing models were examined. A plausible correlational pattern was obtained by using a model that (1) adopts a hemicircular spreading pattern of H2 along an incipient fracture plane from the hypocenter of an earthquake, (2) relies on the FeO-H2O reaction for H2 generation, and (3) relates the accumulated amount of H2 to the mass of serpentinization of underlying ophiolitic rocks; the mass was tentatively assumed to be proportional to the seismic energy of the earthquake.

Silicon nanowire Esaki diodes.

PubMed

Schmid, Heinz; Bessire, Cedric; Björk, Mikael T; Schenk, Andreas; Riel, Heike

2012-02-08

We report on the fabrication and characterization of silicon nanowire tunnel diodes. The silicon nanowires were grown on p-type Si substrates using Au-catalyzed vapor-liquid-solid growth and in situ n-type doping. Electrical measurements reveal Esaki diode characteristics with peak current densities of 3.6 kA/cm(2), peak-to-valley current ratios of up to 4.3, and reverse current densities of up to 300 kA/cm(2) at 0.5 V reverse bias. Strain-dependent current-voltage (I-V) measurements exhibit a decrease of the peak tunnel current with uniaxial tensile stress and an increase of 48% for 1.3 GPa compressive stress along the <111> growth direction, revealing the strain dependence of the Si band structure and thus the tunnel barrier. The contributions of phonons to the indirect tunneling process were probed by conductance measurements at 4.2 K. These measurements show phonon peaks at energies corresponding to the transverse acoustical and transverse optical phonons. In addition, the low-temperature conductance measurements were extended to higher biases to identify potential impurity states in the band gap. The results demonstrate that the most likely impurity, namely, Au from the catalyst particle, is not detectable, a finding that is also supported by the excellent device properties of the Esaki diodes reported here. © 2012 American Chemical Society

Latitude-dependent delay in the responses of the equatorial electrojet and Sq currents to X-class solar flares

NASA Astrophysics Data System (ADS)

Nogueira, Paulo A. B.; Abdu, Mangalathayil A.; Souza, Jonas R.; Denardini, Clezio M.; Barbosa Neto, Paulo F.; Serra de Souza da Costa, João P.; Silva, Ana P. M.

2018-01-01

We have analyzed low-latitude ionospheric current responses to two intense (X-class) solar flares that occurred on 13 May 2013 and 11 March 2015. Sudden intensifications, in response to solar flare radiation impulses, in the Sq and equatorial electrojet (EEJ) currents, as detected by magnetometers over equatorial and low-latitude sites in South America, are studied. In particular we show for the first time that a 5 to 8 min time delay is present in the peak effect in the EEJ, with respect that of Sq current outside the magnetic equator, in response to the flare radiation enhancement. The Sq current intensification peaks close to the flare X-ray peak, while the EEJ peak occurs 5 to 8 min later. We have used the Sheffield University Plasmasphere-Ionosphere Model at National Institute for Space Research (SUPIM-INPE) to simulate the E-region conductivity enhancement as caused by the flare enhanced solar extreme ultraviolet (EUV) and soft X-rays flux. We propose that the flare-induced enhancement in neutral wind occurring with a time delay (with respect to the flare radiation) could be responsible for a delayed zonal electric field disturbance driving the EEJ, in which the Cowling conductivity offers enhanced sensitivity to the driving zonal electric field.

National Borders Effectively Halt the Spread of Rabies: The Current Rabies Epidemic in China Is Dislocated from Cases in Neighboring Countries

PubMed Central

Guo, Zhenyang; Tao, Xiaoyan; Yin, Cuiping; Han, Na; Yu, Jinning; Li, Hao; Liu, Haizhou; Fang, Wei; Adams, James; Wang, Jun; Liang, Guodong; Tang, Qing; Rayner, Simon

2013-01-01

China has seen a massive resurgence of rabies cases in the last 15 years with more than 25,000 human fatalities. Initial cases were reported in the southwest but are now reported in almost every province. There have been several phylogenetic investigations into the origin and spread of the virus within China but few reports investigating the impact of the epidemic on neighboring countries. We therefore collected nucleoprotein sequences from China and South East Asia and investigated their phylogenetic and phylogeographic relationship. Our results indicate that within South East Asia, isolates mainly cluster according to their geographic origin. We found evidence of sporadic exchange of strains between neighboring countries, but it appears that the major strain responsible for the current Chinese epidemic has not been exported. This suggests that national geographical boundaries and border controls are effective at halting the spread of rabies from China into adjacent regions. We further investigated the geographic structure of Chinese sequences and found that the current epidemic is dominated by variant strains that were likely present at low levels in previous domestic epidemics. We also identified epidemiological linkages between high incidence provinces consistent with observations based on surveillance data from human rabies cases. PMID:23383359

National borders effectively halt the spread of rabies: the current rabies epidemic in China is dislocated from cases in neighboring countries.

PubMed

Guo, Zhenyang; Tao, Xiaoyan; Yin, Cuiping; Han, Na; Yu, Jinning; Li, Hao; Liu, Haizhou; Fang, Wei; Adams, James; Wang, Jun; Liang, Guodong; Tang, Qing; Rayner, Simon

2013-01-01

China has seen a massive resurgence of rabies cases in the last 15 years with more than 25,000 human fatalities. Initial cases were reported in the southwest but are now reported in almost every province. There have been several phylogenetic investigations into the origin and spread of the virus within China but few reports investigating the impact of the epidemic on neighboring countries. We therefore collected nucleoprotein sequences from China and South East Asia and investigated their phylogenetic and phylogeographic relationship. Our results indicate that within South East Asia, isolates mainly cluster according to their geographic origin. We found evidence of sporadic exchange of strains between neighboring countries, but it appears that the major strain responsible for the current Chinese epidemic has not been exported. This suggests that national geographical boundaries and border controls are effective at halting the spread of rabies from China into adjacent regions. We further investigated the geographic structure of Chinese sequences and found that the current epidemic is dominated by variant strains that were likely present at low levels in previous domestic epidemics. We also identified epidemiological linkages between high incidence provinces consistent with observations based on surveillance data from human rabies cases.

The evolution of discharge current and channel radius in cloud-to-ground lightning return stroke process

NASA Astrophysics Data System (ADS)

Fan, Tingting; Yuan, Ping; Wang, Xuejuan; Cen, Jianyong; Chang, Xuan; Zhao, Yanyan

2017-09-01

The spectra of two negative cloud-to-ground lightning discharge processes with multi-return strokes are obtained by a slit-less high-speed spectrograph, which the temporal resolution is 110 μs. Combined with the synchronous electrical observation data and theoretical calculation, the physical characteristics during return strokes process are analysed. A positive correlation between discharge current and intensity of ionic lines in the spectra is verified, and based on this feature, the current evolution characteristics during four return strokes are investigated. The results show that the time from peak current to the half-peak value estimated by multi point-fitting is about 101 μs-139 μs. The Joule heat in per unit length of four return strokes channel is in the order of 105J/m-106 J/m. The radius of arc discharge channel is positively related to the discharge current, and the more intense the current is, the greater the radius of channel is. Furthermore, the evolution for radius of arc core channel in the process of return stroke is consistent with the change trend of discharge current after the peak value. Compared with the decay of the current, the temperature decreases more slowly.

Improvement in operational characteristics of KEPCO’s line-commutation-type superconducting hybrid fault current limiter

NASA Astrophysics Data System (ADS)

Yim, S.-W.; Park, B.-C.; Jeong, Y.-T.; Kim, Y.-J.; Yang, S.-E.; Kim, W.-S.; Kim, H.-R.; Du, H.-I.

2013-01-01

A 22.9 kV class hybrid fault current limiter (FCL) developed by Korea Electric Power Corporation and LS Industrial Systems in 2006 operates using the line commutation mechanism and begins to limit the fault current after the first half-cycle. The first peak of the fault current is available for protective coordination in the power system. However, it also produces a large electromagnetic force and imposes a huge stress on power facilities such as the main transformer and gas-insulated switchgear. In this study, we improved the operational characteristics of the hybrid FCL in order to reduce the first peak of the fault current. While maintaining the structure of the hybrid FCL system, we developed a superconducting module that detects and limits the fault current during the first half-cycle. To maintain the protective coordination capacity, the hybrid FCL was designed to reduce the first peak value of the fault current by up to approximately 30%. The superconducting module was also designed to produce a minimum AC loss, generating a small, uniform magnetic field distribution during normal operation. Performance tests confirmed that when applied to the hybrid FCL, the superconducting module showed successful current limiting operation without any damage.

Modeling Viral Spread

PubMed Central

Graw, Frederik; Perelson, Alan S.

2016-01-01

The way in which a viral infection spreads within a host is a complex process that is not well understood. Different viruses, such as human immunodeficiency virus type 1 and hepatitis C virus, have evolved different strategies, including direct cell-to-cell transmission and cell-free transmission, to spread within a host. To what extent these two modes of transmission are exploited in vivo is still unknown. Mathematical modeling has been an essential tool to get a better systematic and quantitative understanding of viral processes that are difficult to discern through strictly experimental approaches. In this review, we discuss recent attempts that combine experimental data and mathematical modeling in order to determine and quantify viral transmission modes. We also discuss the current challenges for a systems-level understanding of viral spread, and we highlight the promises and challenges that novel experimental techniques and data will bring to the field. PMID:27618637

A simplified controller and detailed dynamics of constant off-time peak current control

NASA Astrophysics Data System (ADS)

Van den Bossche, Alex; Dimitrova, Ekaterina; Valchev, Vencislav; Feradov, Firgan

2017-09-01

A fast and reliable current control is often the base of power electronic converters. The traditional constant frequency peak control is unstable above 50 % duty ratio. In contrast, the constant off-time peak current control (COTCC) is unconditionally stable and fast, so it is worth analyzing it. Another feature of the COTCC is that one can combine a current control together with a current protection. The time dynamics show a zero-transient response, even when the inductor changes in a wide range. It can also be modeled as a special transfer function for all frequencies. The article shows also that it can be implemented in a simple analog circuit using a wide temperature range IC, such as the LM2903, which is compatible with PV conversion and automotive temperature range. Experiments are done using a 3 kW step-up converter. A drawback is still that the principle does not easily fit in usual digital controllers up to now.

Geothermal-retrofit study for the National Orange Show Facilities in San Bernardino, California

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1981-11-17

The cost and feasibility of retrofitting the National Orange Show Facilities to use geothermal heat instead of natural gas for heating are determined. Because of the limited usage of the smaller facilities the study was limited to the conversion of the six major buildings: Domed, Hobby, Citrus, Auditorium, Restaurant and Commercial. A major problem is that most of the buildings are used on a very limited basis. This drastically reduced the amount of savings that could be used to amortize the retrofit cost. Another problem is that the buildings are spread over a large area and so the below grademore » piping costs were high. Finally, all of the buildings except for the Auditorium have direct gas fired heaters that would require all new terminal heating systems. In order to limit the retrofit cost, the retrofit system was designed to handle less than the peak load. This seemed appropriate because the facility might not even be in operation when a peak load condition occurred. Also, the existing systems could be used to supplement the geothermal system if necessary. The calculated and design peak loads are summarized.« less

Rare earth substitution on structural and optical behaviour of CdSe thin films

NASA Astrophysics Data System (ADS)

Singh, Sarika; Shrivastava, A. K.; Tapdiya, Swati

2018-05-01

A series of Sm2+,Gd2+ doped with Cadmium selenide CdSe (x =0.01) has been prepared by using Chemical bath deposition technique. Structural, Optical and Morphological studies were performed using X-ray diffraction (XRD), UV-Visible spectrometer, Raman Studies and Scanning Electron Microscopy (SEM). XRD patterns confirm the samples with Sm,Gd ions, some diffraction peaks appeared which belongs to the cubic phase structure. The values of lattice parameter (a) decreased and particle size decrease on doping. Morphology of the grown films reveals that surface are homogeneous and uniformly spread on the substrates. The elemental analysis of CdSe doped Sm and Gd (1%) different composition was analyzed by Energy Dispersive X-Rays (EDX). The optical values of some important parameters of the studied films were calculated by UVstudy are determined from transmission spectra at wavelength 200 to 900nm. Optical band gap Eg was calculated by tauc relation. Energy band gap of CdSe doped with Sm and Gd varies at 1.8eV and 1.9eV respectively. Bandgap In Raman analysis, a prominent peak shows that confirmation of nano crystalline phase. And intensity of peaks was decreasing after doping.

Dose response of alanine detectors irradiated with carbon ion beams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Herrmann, Rochus; Jaekel, Oliver; Palmans, Hugo

Purpose: The dose response of the alanine detector shows a dependence on particle energy and type when irradiated with ion beams. The purpose of this study is to investigate the response behavior of the alanine detector in clinical carbon ion beams and compare the results to model predictions. Methods: Alanine detectors have been irradiated with carbon ions with an energy range of 89-400 MeV/u. The relative effectiveness of alanine has been measured in this regime. Pristine and spread out Bragg peak depth-dose curves have been measured with alanine dosimeters. The track structure based alanine response model developed by Hansen andmore » Olsen has been implemented in the Monte Carlo code FLUKA and calculations were compared to experimental results. Results: Calculations of the relative effectiveness deviate less than 5% from the measured values for monoenergetic beams. Measured depth-dose curves deviate from predictions in the peak region, most pronounced at the distal edge of the peak. Conclusions: The used model and its implementation show a good overall agreement for quasimonoenergetic measurements. Deviations in depth-dose measurements are mainly attributed to uncertainties of the detector geometry implemented in the Monte Carlo simulations.« less

431 kA/cm2 peak tunneling current density in GaN/AlN resonant tunneling diodes

NASA Astrophysics Data System (ADS)

Growden, Tyler A.; Zhang, Weidong; Brown, Elliott R.; Storm, David F.; Hansen, Katurah; Fakhimi, Parastou; Meyer, David J.; Berger, Paul R.

2018-01-01

We report on the design and fabrication of high current density GaN/AlN double barrier resonant tunneling diodes grown via plasma assisted molecular-beam epitaxy on bulk GaN substrates. A quantum-transport solver was used to model and optimize designs with high levels of doping and ultra-thin AlN barriers. The devices displayed repeatable room temperature negative differential resistance with peak-to-valley current ratios ranging from 1.20 to 1.60. A maximum peak tunneling current density (Jp) of 431 kA/cm2 was observed. Cross-gap near-UV (370-385 nm) electroluminescence (EL) was observed above +6 V when holes, generated from a polarization induced Zener tunneling effect, recombine with electrons in the emitter region. Analysis of temperature dependent measurements, thermal resistance, and the measured EL spectra revealed the presence of severe self-heating effects.

Numerical investigation of the effect of driving voltage pulse shapes on the characteristics of low-pressure argon dielectric barrier discharge

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eslami, E., E-mail: eeslami@iust.ac.ir; Barjasteh, A.; Morshedian, N.

2015-06-15

In this work, we numerically compare the effect of a sinusoidal, triangular, and rectangular pulsed voltage profile on the calculated particle production, electric current, and gas voltage in a dielectric barrier discharge. The total argon gas pressure of 400 Pa, the distance between dielectrics of 5 mm, the dielectric thickness of 0.7 mm, and the temperature of T = 300 K were considered as input parameters. The different driving voltage pulse shapes (triangular, rectangular, and sinusoidal) are considered as applied voltage with a frequency of 7 kHz and an amplitude of 700 V peak to peak. It is shown thatmore » applying a rectangular voltage, as compared with a sinusoidal or triangle voltage, increases the current peak, while the peak width is decreased. Higher current density is related to high production of charged particles, which leads to the generation of some highly active species, such as Ar* (4s level), and Ar** (4p level) in the gap.« less

Modelling of electric characteristics of 150-watt peak solar panel using Boltzmann sigmoid function under various temperature and irradiance

NASA Astrophysics Data System (ADS)

Sapteka, A. A. N. G.; Narottama, A. A. N. M.; Winarta, A.; Amerta Yasa, K.; Priambodo, P. S.; Putra, N.

2018-01-01

Solar energy utilized with solar panel is a renewable energy that needs to be studied further. The site nearest to the equator, it is not surprising, receives the highest solar energy. In this paper, a modelling of electrical characteristics of 150-Watt peak solar panels using Boltzmann sigmoid function under various temperature and irradiance is reported. Current, voltage, temperature and irradiance data in Denpasar, a city located at just south of equator, was collected. Solar power meter is used to measure irradiance level, meanwhile digital thermometer is used to measure temperature of front and back panels. Short circuit current and open circuit voltage data was also collected at different temperature and irradiance level. Statistically, the electrical characteristics of 150-Watt peak solar panel can be modelled using Boltzmann sigmoid function with good fit. Therefore, it can be concluded that Boltzmann sigmoid function might be used to determine current and voltage characteristics of 150-Watt peak solar panel under various temperature and irradiance.

Proton Therapy At Siteman Cancer Center: The State Of The Art

NASA Astrophysics Data System (ADS)

Bloch, Charles

2011-06-01

Barnes-Jewish Hospital is on the verge of offering proton radiation therapy to its patients. Those treatments will be delivered from the first Monarch 250, a state-of-the-art cyclotron produced by Still River Systems, Inc., Littleton, MA. The accelerator is the world's first superconducting synchrocyclotron, with a field-strength of 10 tesla, providing the smallest accelerator for high-energy protons currently available. On May 14, 2010 it was announced that the first production unit had successfully extracted 250 MeV protons. That unit is scheduled for delivery to the Siteman Cancer Center, an NCI-designated Comprehensive Cancer Center at Washington University School of Medicine. At a weight of 20 tons and with a diameter of less than 2 meters the compact cyclotron will be mounted on a gantry, another first for proton therapy systems. The single-energy system includes 3 contoured scatterers and 14 different range modulators to provide 24 distinct beam delivery configurations. This allows proton fields up to 25 cm in diameter, with a maximum range from 5.5 to 32 cm and spread-out-Bragg-peak extent up to 20 cm. Monte Carlo simulations have been run using MCNPX to simulate the clinical beam properties. Those calculations have been used to commission a commercial treatment planning system prior to final clinical measurements. MCNPX was also used to calculate the neutron background generated by protons in the scattering system and patient. Additional details of the facility and current status will be presented.

Multi-mechanism efficiency enhancement in growing Ga-doped ZnO as the transparent conductor on a light-emitting diode.

PubMed

Yao, Yu-Feng; Lin, Chun-Han; Hsieh, Chieh; Su, Chia-Ying; Zhu, Erwin; Yang, Shaobo; Weng, Chi-Ming; Su, Ming-Yen; Tsai, Meng-Che; Wu, Shang-Syuan; Chen, Sheng-Hung; Tu, Charng-Gan; Chen, Hao-Tsung; Kiang, Yean-Woei; Yang, C C

2015-12-14

The combined effects of a few mechanisms for emission efficiency enhancement produced in the overgrowth of the transparent conductor layer of Ga-doped ZnO (GaZnO) on a surface Ag-nanoparticle (NP) coated light-emitting diode (LED), including surface plasmon (SP) coupling, current spreading, light extraction, and contact resistivity reduction, are demonstrated. With a relatively higher GaZnO growth temperature (350 °C), melted Ag NPs can be used as catalyst for forming GaZnO nanoneedles (NNs) through the vapor-liquid-solid growth mode such that light extraction efficiency can be increased. Meanwhile, residual Ag NPs are buried in a simultaneously grown GaZnO layer for inducing SP coupling. With a relatively lower GaZnO growth temperature (250 °C), all the Ag NPs are preserved for generating a stronger SP coupling effect. By using a thin annealed GaZnO interlayer on p-GaN before Ag NP fabrication, the contact resistivity at the GaZnO/p-GaN interface and hence the overall device resistance can be reduced. Although the use of this interlayer blue-shifts the localized surface plasmon resonance peak of the fabricated Ag NPs from the quantum well emission wavelength of the current study (535 nm) such that the SP coupling effect becomes weaker, it is useful for enhancing the SP coupling effect in an LED with a shorter emission wavelength.

Techniques for the measurement of disruption halo currents in the National Spherical Torus Experiment.

PubMed

Gerhardt, S P; Fredrickson, E; Guttadora, L; Kaita, R; Kugel, H; Menard, J; Takahashi, H

2011-10-01

This paper describes techniques for measuring halo currents, and their associated toroidal peaking, in the National Spherical Torus Experiments [M. Ono et al., Nucl. Fusion 40, 557 (2000)]. The measurements are based on three techniques: (1) measurement of the toroidal field created by the poloidal halo current, either with segmented Rogowski coils or discrete toroidal field sensors, (2) the direct measurement of halo currents into specially instrument tiles, and (3) small Rogowski coils placed on the mechanical supports of in-vessel components. For the segmented Rogowski coils and discrete toroidal field detectors, it is shown that the toroidal peaking factor inferred from the data is significantly less than the peaking factor of the underlying halo current distribution, and a simple model is developed to relate the two. For the array of discrete toroidal field detectors and small Rogowski sensors, the compensation steps that are used to isolate the halo current signal are described. The electrical and mechanical design of compact under-tile resistive shunts and mini-Rogowski coils is described. Example data from the various systems are shown.

Calibration tests on magnetic tape lightning current detectors

NASA Technical Reports Server (NTRS)

Crouch, K. E.

1980-01-01

The low cost, passive, peak lightning current detector (LCD) invented at the NASA/Kennedy Space Center, uses magnetic audio recording tape to sense the magnitude of the peak magnetic field around a conductor carrying lightning currents. Test results show that the length of audio tape erased was linearly related to the peak simulated lightning currents in a round conductor. Accuracies of + or - 10% were shown for measurements made using a stopwatch readout technique to determine the amount of tape erased by the lightning current. The stopwatch technique is a simple, low cost means of obtaining LCD readouts and can be used in the field to obtain immediate results. Where more accurate data are desired, the tape is played and the output recorded on a strip chart, oscilloscope, or some other means so that measurements can be made on that recording. Conductor dimensions, tape holder dimensions, and tape formulation must also be considered to obtain a more accurate result. If the shape of the conductor is other than circular (i.e., angle, channel, H-beam), an analysis of the magnetic field is required to use an LCD, especially at low current levels.

Numerical and experimental investigation of GaN-based flip-chip light-emitting diodes with highly reflective Ag/TiW and ITO/DBR Ohmic contacts.

PubMed

Zhou, Shengjun; Liu, Xingtong; Gao, Yilin; Liu, Yingce; Liu, Mengling; Liu, Zongyuan; Gui, Chengqun; Liu, Sheng

2017-10-30

We demonstrate two types of GaN-based flip-chip light-emitting diodes (FCLEDs) with highly reflective Ag/TiW and indium-tin oxide (ITO)/distributed Bragg reflector (DBR) p-type Ohmic contacts. We show that a direct Ohmic contact to p-GaN layer using pure Ag is obtained when annealed at 600°C in N 2 ambient. A TiW diffusion barrier layer covered onto Ag is used to suppress the agglomeration of Ag and thus maintain high reflectance of Ag during high temperature annealing process. We develop a strip-shaped SiO 2 current blocking layer beneath the ITO/DBR to alleviate current crowding occurring in FCLED with ITO/DBR. Owing to negligibly small spreading resistance of Ag, however, our combined numerical and experimental results show that the FCLED with Ag/TiW has a more favorable current spreading uniformity in comparison to the FCLED with ITO/DBR. As a result, the light output power of FCLED with Ag/TiW is 7.5% higher than that of FCLED with ITO/DBR at 350 mA. The maximum output power of the FCLED with Ag/TiW obtained at 305.6 A/cm 2 is 29.3% larger than that of the FCLED with ITO/DBR obtained at 278.9 A/cm 2 . The improvement appears to be due to the enhanced current spreading and higher optical reflectance provided by the Ag/TiW.

Improving Speech Perception in Noise with Current Focusing in Cochlear Implant Users

PubMed Central

Srinivasan, Arthi G.; Padilla, Monica; Shannon, Robert V.; Landsberger, David M.

2013-01-01

Cochlear implant (CI) users typically have excellent speech recognition in quiet but struggle with understanding speech in noise. It is thought that broad current spread from stimulating electrodes causes adjacent electrodes to activate overlapping populations of neurons which results in interactions across adjacent channels. Current focusing has been studied as a way to reduce spread of excitation, and therefore, reduce channel interactions. In particular, partial tripolar stimulation has been shown to reduce spread of excitation relative to monopolar stimulation. However, the crucial question is whether this benefit translates to improvements in speech perception. In this study, we compared speech perception in noise with experimental monopolar and partial tripolar speech processing strategies. The two strategies were matched in terms of number of active electrodes, microphone, filterbanks, stimulation rate and loudness (although both strategies used a lower stimulation rate than typical clinical strategies). The results of this study showed a significant improvement in speech perception in noise with partial tripolar stimulation. All subjects benefited from the current focused speech processing strategy. There was a mean improvement in speech recognition threshold of 2.7 dB in a digits in noise task and a mean improvement of 3 dB in a sentences in noise task with partial tripolar stimulation relative to monopolar stimulation. Although the experimental monopolar strategy was worse than the clinical, presumably due to different microphones, frequency allocations and stimulation rates, the experimental partial-tripolar strategy, which had the same changes, showed no acute deficit relative to the clinical. PMID:23467170

Driving reconnection in sheared magnetic configurations with forced fluctuations

NASA Astrophysics Data System (ADS)

Pongkitiwanichakul, Peera; Makwana, Kirit D.; Ruffolo, David

2018-02-01

We investigate reconnection of magnetic field lines in sheared magnetic field configurations due to fluctuations driven by random forcing by means of numerical simulations. The simulations are performed with an incompressible, pseudo-spectral magnetohydrodynamics code in 2D where we take thick, resistively decaying, current-sheet like sheared magnetic configurations which do not reconnect spontaneously. We describe and test the forcing that is introduced in the momentum equation to drive fluctuations. It is found that the forcing does not change the rate of decay; however, it adds and removes energy faster in the presence of the magnetic shear structure compared to when it has decayed away. We observe that such a forcing can induce magnetic reconnection due to field line wandering leading to the formation of magnetic islands and O-points. These reconnecting field lines spread out as the current sheet decays with time. A semi-empirical formula is derived which reasonably explains the formation and spread of O-points. We find that reconnection spreads faster with stronger forcing and longer correlation time of forcing, while the wavenumber of forcing does not have a significant effect. When the field line wandering becomes large enough, the neighboring current sheets with opposite polarity start interacting, and then the magnetic field is rapidly annihilated. This work is useful to understand how forced fluctuations can drive reconnection in large scale current structures in space and astrophysical plasmas that are not susceptible to reconnection.

A Spatial Modeling Approach to Predicting the Secondary Spread of Invasive Species Due to Ballast Water Discharge

PubMed Central

Sieracki, Jennifer L.; Bossenbroek, Jonathan M.; Chadderton, W. Lindsay

2014-01-01

Ballast water in ships is an important contributor to the secondary spread of invasive species in the Laurentian Great Lakes. Here, we use a model previously created to determine the role ballast water management has played in the secondary spread of viral hemorrhagic septicemia virus (VHSV) to identify the future spread of one current and two potential invasive species in the Great Lakes, the Eurasian Ruffe (Gymnocephalus cernuus), killer shrimp (Dikerogammarus villosus), and golden mussel (Limnoperna fortunei), respectively. Model predictions for Eurasian Ruffe have been used to direct surveillance efforts within the Great Lakes and DNA evidence of ruffe presence was recently reported from one of three high risk port localities identified by our model. Predictions made for killer shrimp and golden mussel suggest that these two species have the potential to become rapidly widespread if introduced to the Great Lakes, reinforcing the need for proactive ballast water management. The model used here is flexible enough to be applied to any species capable of being spread by ballast water in marine or freshwater ecosystems. PMID:25470822

Predicted Spatial Spread of Canine Rabies in Australia

PubMed Central

Fleming, Peter J. S.; Ward, Michael P.; Davis, Stephen A.

2017-01-01

Modelling disease dynamics is most useful when data are limited. We present a spatial transmission model for the spread of canine rabies in the currently rabies-free wild dog population of Australia. The introduction of a sub-clinically infected dog from Indonesia is a distinct possibility, as is the spillover infection of wild dogs. Ranges for parameters were estimated from the literature and expert opinion, or set to span an order of magnitude. Rabies was judged to have spread spatially if a new infectious case appeared 120 km from the index case. We found 21% of initial value settings resulted in canine rabies spreading 120km, and on doing so at a median speed of 67 km/year. Parameters governing dog movements and behaviour, around which there is a paucity of knowledge, explained most of the variance in model outcomes. Dog density, especially when interactions with other parameters were included, explained some of the variance in whether rabies spread 120km, but dog demography (mean lifespan and mean replacement period) had minimal impact. These results provide a clear research direction if Australia is to improve its preparedness for rabies. PMID:28114327

Using the Gravity Model to Estimate the Spatial Spread of Vector-Borne Diseases

PubMed Central

Barrios, José Miguel; Verstraeten, Willem W.; Maes, Piet; Aerts, Jean-Marie; Farifteh, Jamshid; Coppin, Pol

2012-01-01

The gravity models are commonly used spatial interaction models. They have been widely applied in a large set of domains dealing with interactions amongst spatial entities. The spread of vector-borne diseases is also related to the intensity of interaction between spatial entities, namely, the physical habitat of pathogens’ vectors and/or hosts, and urban areas, thus humans. This study implements the concept behind gravity models in the spatial spread of two vector-borne diseases, nephropathia epidemica and Lyme borreliosis, based on current knowledge on the transmission mechanism of these diseases. Two sources of information on vegetated systems were tested: the CORINE land cover map and MODIS NDVI. The size of vegetated areas near urban centers and a local indicator of occupation-related exposure were found significant predictors of disease risk. Both the land cover map and the space-borne dataset were suited yet not equivalent input sources to locate and measure vegetated areas of importance for disease spread. The overall results point at the compatibility of the gravity model concept and the spatial spread of vector-borne diseases. PMID:23202882

Using the gravity model to estimate the spatial spread of vector-borne diseases.

PubMed

Barrios, José Miguel; Verstraeten, Willem W; Maes, Piet; Aerts, Jean-Marie; Farifteh, Jamshid; Coppin, Pol

2012-11-30

The gravity models are commonly used spatial interaction models. They have been widely applied in a large set of domains dealing with interactions amongst spatial entities. The spread of vector-borne diseases is also related to the intensity of interaction between spatial entities, namely, the physical habitat of pathogens’ vectors and/or hosts, and urban areas, thus humans. This study implements the concept behind gravity models in the spatial spread of two vector-borne diseases, nephropathia epidemica and Lyme borreliosis, based on current knowledge on the transmission mechanism of these diseases. Two sources of information on vegetated systems were tested: the CORINE land cover map and MODIS NDVI. The size of vegetated areas near urban centers and a local indicator of occupation-related exposure were found significant predictors of disease risk. Both the land cover map and the space-borne dataset were suited yet not equivalent input sources to locate and measure vegetated areas of importance for disease spread. The overall results point at the compatibility of the gravity model concept and the spatial spread of vector-borne diseases.

Magma plumbing system and seismicity of an active mid-ocean ridge volcano.

PubMed

Schmid, Florian; Schlindwein, Vera; Koulakov, Ivan; Plötz, Aline; Scholz, John-Robert

2017-02-20

At mid-ocean ridges volcanism generally decreases with spreading rate but surprisingly massive volcanic centres occur at the slowest spreading ridges. These volcanoes can host unexpectedly strong earthquakes and vigorous, explosive submarine eruptions. Our understanding of the geodynamic processes forming these volcanic centres is still incomplete due to a lack of geophysical data and the difficulty to capture their rare phases of magmatic activity. We present a local earthquake tomographic image of the magma plumbing system beneath the Segment 8 volcano at the ultraslow-spreading Southwest Indian Ridge. The tomography shows a confined domain of partial melt under the volcano. We infer that from there melt is horizontally transported to a neighbouring ridge segment at 35 km distance where microearthquake swarms and intrusion tremor occur that suggest ongoing magmatic activity. Teleseismic earthquakes around the Segment 8 volcano, prior to our study, indicate that the current magmatic spreading episode may already have lasted over a decade and hence its temporal extent greatly exceeds the frequent short-lived spreading episodes at faster opening mid-ocean ridges.

Distribution and abundance of saltcedar and Russian olive in the western United States

USGS Publications Warehouse

Nagler, Pamela L.; Glenn, Edward P.; Jarnevich, Catherine S.; Shafroth, Patrick B.

2011-01-01

Over the past century, two introduced Eurasian trees, saltcedar (Tamarix spp.) and Russian olive (Elaeagnus angustifolia) have become wide spread on western United States of American (U.S.) rivers. This paper reviews the literature on the following five key areas related to their distribution and abundance in the western United States: (1) the history of introduction, planting, and spread of saltcedar and Russian olive; (2) their current distribution; (3) their current abundance; (4) factors controlling their current distribution and abundance; and (5) models that have been developed to predict their future distribution and abundance. Saltcedar and Russian olive are now the third and fourth most frequently occurring woody riparian plants and the second and fifth most abundant species (out of 42 native and non-native species) along rivers in the western United States. Currently there is not a precise estimate of the areas that these species occupy in the entire West. Climatic variables are important determinants of their distribution and abundance. For example, saltcedar is limited by its sensitivity to hard freezes, whereas Russian olive appears to have a chilling requirement for bud break and seed germination, and can presumably survive colder winter temperatures. Either species can be dominant, co-dominant or sub-dominant relative to native species on a given river system. A number of environmental factors such as water availability, soil salinity, degree of stream flow regulation, and fire frequency can influence the abundance of these species relative to native species. Numerous studies suggest that both species have spread on western rivers primarily through a replacement process, whereby stress-tolerant species have moved into expanded niches that are no longer suitable for mesic native pioneer species. Better maps of current distribution and rigorous monitoring of distributional changes though time can help to resolve differences in predictions of potential future spread. An adequate understanding does not yet exist of what fraction of western riparian zones is resistant to dominance by either of these species, what fraction is at risk and could benefit from intervention, and what fraction has been altered to the point that saltcedar or Russian olive are most likely to thrive.

Innate immune response to Rift Valley fever virus in goats.

PubMed

Nfon, Charles K; Marszal, Peter; Zhang, Shunzhen; Weingartl, Hana M

2012-01-01

Rift Valley fever (RVF), a re-emerging mosquito-borne disease of ruminants and man, was endemic in Africa but spread to Saudi Arabia and Yemen, meaning it could spread even further. Little is known about innate and cell-mediated immunity to RVF virus (RVFV) in ruminants, which is knowledge required for adequate vaccine trials. We therefore studied these aspects in experimentally infected goats. We also compared RVFV grown in an insect cell-line and that grown in a mammalian cell-line for differences in the course of infection. Goats developed viremia one day post infection (DPI), which lasted three to four days and some goats had transient fever coinciding with peak viremia. Up to 4% of peripheral blood mononuclear cells (PBMCs) were positive for RVFV. Monocytes and dendritic cells in PBMCs declined possibly from being directly infected with virus as suggested by in vitro exposure. Infected goats produced serum IFN-γ, IL-12 and other proinflammatory cytokines but not IFN-α. Despite the lack of IFN-α, innate immunity via the IL-12 to IFN-γ circuit possibly contributed to early protection against RVFV since neutralising antibodies were detected after viremia had cleared. The course of infection with insect cell-derived RVFV (IN-RVFV) appeared to be different from mammalian cell-derived RVFV (MAM-RVFV), with the former attaining peak viremia faster, inducing fever and profoundly affecting specific immune cell subpopulations. This indicated possible differences in infections of ruminants acquired from mosquito bites relative to those due to contact with infectious material from other animals. These differences need to be considered when testing RVF vaccines in laboratory settings.

The Kansas PEAK 2.0 Program Facilitates the Diffusion of Culture-Change Innovation to Unlikely Adopters.

PubMed

Hermer, Linda; Cornelison, Laci; Kaup, Migette L; Poey, Judith L; Stone, Robyn; Doll, Gayle

2018-05-08

Recent studies have shown that nursing homes adopting culture change are disproportionately not-for-profit and CCRC-affiliated, with greater quality of care. Through the lens of diffusion-of-innovation theory, we examined whether Kansas' Medicaid pay-for-performance program PEAK 2.0, which incents the adoption of person-centered care (PCC) and worker empowerment, succeeded in its goal of spreading adoption to atypical- as well as typical-adopting nursing homes. We conducted a retrospective cohort study of 349 nursing homes in the state during PEAK 2.0's existence, 2012-2016. We constructed a data set combining state program data, provider characteristics from CMS data sets, and other demographic information from the 2010 Census. With a series of logistic regression models, we tested whether program joiners differed from nonjoiners by profit status and other demographic factors, as well as quality-related and case-mix factors. We found that in PEAK 2.0's first year, 2012, adopters were more likely to be not-for-profit and part of a CCRC, with higher occupancy rates and greater quality. However, by 2013 these associations became marginal, and in 2014 and 2015, we found no differences between program joiners and nonjoiners. The results show that by PEAK 2.0's third year, the program-with its large financial incentive and other potentially important characteristics-succeeded in attracting a large set of nursing homes whose demographics were representative of those in the state. This is important because other studies have found that the adoption of PCC is associated with improved health and well-being for residents.

Seasonal Variation in Meteor Decay Time Profiles Measured by a Meteor Radar at King Sejong Station (62°S, 58°W), Antarctica

NASA Astrophysics Data System (ADS)

Kim, Y.; Kim, J.; Lee, C.; Jee, G.

2008-12-01

A VHF meteor radar at King Sejong Station (62°S, 58°W), Antarctica has been detecting echoes from more than 20,000 meteors per day since March 2007. Meteor echoes are decayed typically within seconds as meteor trail plasma spread away or are neutralized. Assuming that diffusion is the only process for decay of meteor echo signals, the atmospheric temperatures and pressures have been inferred from the measured meteor decay times at the peak meteor altitudes around 90 km. In this study, we analyze altitude profiles of meteor decay times in each month, which clearly show a maximum at 80 ~ 85 km. The maximum appears at higher altitude during austral summer than winter. The fast decay of meteor signals below the maximum cannot be explained by atmospheric diffusion which decreases with increasing atmospheric densities. We find that the measured meteor decay time profiles can be fitted with a loss rate profile, in addition to diffusion, with a peak altitude of 55 ~ 73 km and a peak rate of 4 ~ 15 sec- 1. The additional loss of meteor plasma may be due to electron absorption by icy particles in the mesosphere, but the estimated peak altitudes are much lower than the layers of NLC or PME. The estimated peak loss rates seem to be too large to be accounted by absorption by icy or dust particles. We will discuss other processes to explain the fast meteor times and their variation over season.

Order flow dynamics around extreme price changes on an emerging stock market

NASA Astrophysics Data System (ADS)

Mu, Guo-Hua; Zhou, Wei-Xing; Chen, Wei; Kertész, János

2010-07-01

We study the dynamics of order flows around large intraday price changes using ultra-high-frequency data from the Shenzhen Stock Exchange. We find a significant reversal of price for both intraday price decreases and increases with a permanent price impact. The volatility, the volume of different types of orders, the bid-ask spread and the volume imbalance increase before the extreme events and decay slowly as a power law, which forms a well-established peak. The volume of buy market orders increases faster and the corresponding peak appears earlier than for sell market orders around positive events, while the volume peak of sell market orders leads buy market orders in the magnitude and time around negative events. When orders are divided into four groups according to their aggressiveness, we find that the behaviors of order volume and order number are similar, except for buy limit orders and canceled orders that the peak of order number postpones 2 min later after the peak of order volume, implying that investors placing large orders are more informed and play a central role in large price fluctuations. We also study the relative rates of different types of orders and find differences in the dynamics of relative rates between buy orders and sell orders and between individual investors and institutional investors. There is evidence that institutions behave very differently from individuals and that they have more aggressive strategies. Combining these findings, we conclude that institutional investors are better informed and play a more influential role in driving large price fluctuations.

A Characterization of the Radiation from a Rod-Pinch Diode

NASA Astrophysics Data System (ADS)

Swanekamp, Stephen B.; Allen, Raymond J.; Hinshelwood, David D.; Mosher, David; Schumer, Joseph W.

2002-12-01

Coupled PIC-Monte-Carlo simulations of the electron-flow and radiation production in a rod-pinch diode show that multiple scatterings in the rod produce incident electron energies that ranging from zero to slightly higher than the applied voltage. It is speculated that those electrons that gain energy do so by remaining in phase with a rapidly varying electric field near the tip of the rod. The simulations also show that multiple passes in the rod produce a wide spread in incident electron angles. For diode voltages of V=2 MV, the angular distribution of electrons incident on the rod is broad and peaked near 90° to the axis of the rod with a larger fraction of electrons striking the rod at angles less than 90°. The electron angular distribution for V=4 MV is narrower and peaked at 105° with a larger fraction of electrons incident on the rod with angles greater than 90°. The photon distributions are peaked along the direction of the high-energy electrons. For V=2 MV the dose filtered through 21/4-cm thick Plexiglas is peaked at 90° and is 1.8 times higher than the forward-directed [0°] dose. For V=4 MV the dose filtered through 21/4-cm thick Plexiglas is peaked at 120° and is 2.3 times higher than the forward-directed dose. Similar angular variation of the dose has been observed on the 4-MV Asterix accelerator [2] and on 1-2 MV accelerators at the Atomic Weapons Establishment [8].

Generic evolution of mixing in heterogeneous media

NASA Astrophysics Data System (ADS)

De Dreuzy, J.; Carrera, J.; Dentz, M.; Le Borgne, T.

2011-12-01

Mixing in heterogeneous media results from the competition bewteen flow fluctuations and local scale diffusion. Flow fluctuations quickly create concentration contrasts and thus heterogeneity of the concentration field, which is slowly homogenized by local scale diffusion. Mixing first deviates from Gaussian mixing, which represents the potential mixing induced by spreading before approaching it. This deviation fundamentally expresses the evolution of the interaction between spreading and local scale diffusion. We characterize it by the ratio γ of the non-Gaussian to the Gaussian mixing states. We define the Gaussian mixing state as the integrated squared concentration of the Gaussian plume that has the same longitudinal dispersion as the real plume. The non-Gaussian mixing state is the difference between the overall mixing state defined as the integrated squared concentration and the Gaussian mixing state. The main advantage of this definition is to use the full knowledge previously acquired on dispersion for characterizing mixing even when the solute concentration field is highly non Gaussian. Using high precision numerical simulations, we show that γ quickly increases, peaks and slowly decreases. γ can be derived from two scales characterizing spreading and local mixing, at least for large flux-weighted solute injection conditions into classically log-normal Gaussian correlated permeability fields. The spreading scale is directly related to the longitudinal dispersion. The local mixing scale is the largest scale over which solute concentrations can be considered locally uniform. More generally, beyond the characteristics of its maximum, γ turns out to have a highly generic scaling form. Its fast increase and slow decrease depend neither on the heterogeneity level, nor on the ratio of diffusion to advection, nor on the injection conditions. They might even not depend on the particularities of the flow fields as the same generic features also prevail for Taylor dispersion. This generic characterization of mixing can offer new ways to set up transport equations that honor not only advection and spreading (dispersion), but also mixing.

Laser-plasmas in the relativistic-transparency regime: Science and applications

NASA Astrophysics Data System (ADS)

Fernández, Juan C.; Cort Gautier, D.; Huang, Chengkung; Palaniyappan, Sasikumar; Albright, Brian J.; Bang, Woosuk; Dyer, Gilliss; Favalli, Andrea; Hunter, James F.; Mendez, Jacob; Roth, Markus; Swinhoe, Martyn; Bradley, Paul A.; Deppert, Oliver; Espy, Michelle; Falk, Katerina; Guler, Nevzat; Hamilton, Christopher; Hegelich, Bjorn Manuel; Henzlova, Daniela; Ianakiev, Kiril D.; Iliev, Metodi; Johnson, Randall P.; Kleinschmidt, Annika; Losko, Adrian S.; McCary, Edward; Mocko, Michal; Nelson, Ronald O.; Roycroft, Rebecca; Santiago Cordoba, Miguel A.; Schanz, Victor A.; Schaumann, Gabriel; Schmidt, Derek W.; Sefkow, Adam; Shimada, Tsutomu; Taddeucci, Terry N.; Tebartz, Alexandra; Vogel, Sven C.; Vold, Erik; Wurden, Glen A.; Yin, Lin

2017-05-01

Laser-plasma interactions in the novel regime of relativistically induced transparency (RIT) have been harnessed to generate intense ion beams efficiently with average energies exceeding 10 MeV/nucleon (>100 MeV for protons) at "table-top" scales in experiments at the LANL Trident Laser. By further optimization of the laser and target, the RIT regime has been extended into a self-organized plasma mode. This mode yields an ion beam with much narrower energy spread while maintaining high ion energy and conversion efficiency. This mode involves self-generation of persistent high magnetic fields (˜104 T, according to particle-in-cell simulations of the experiments) at the rear-side of the plasma. These magnetic fields trap the laser-heated multi-MeV electrons, which generate a high localized electrostatic field (˜0.1 T V/m). After the laser exits the plasma, this electric field acts on a highly structured ion-beam distribution in phase space to reduce the energy spread, thus separating acceleration and energy-spread reduction. Thus, ion beams with narrow energy peaks at up to 18 MeV/nucleon are generated reproducibly with high efficiency (≈5%). The experimental demonstration has been done with 0.12 PW, high-contrast, 0.6 ps Gaussian 1.053 μm laser pulses irradiating planar foils up to 250 nm thick at 2-8 × 1020 W/cm2. These ion beams with co-propagating electrons have been used on Trident for uniform volumetric isochoric heating to generate and study warm-dense matter at high densities. These beam plasmas have been directed also at a thick Ta disk to generate a directed, intense point-like Bremsstrahlung source of photons peaked at ˜2 MeV and used it for point projection radiography of thick high density objects. In addition, prior work on the intense neutron beam driven by an intense deuterium beam generated in the RIT regime has been extended. Neutron spectral control by means of a flexible converter-disk design has been demonstrated, and the neutron beam has been used for point-projection imaging of thick objects. The plans and prospects for further improvements and applications are also discussed.

SU-F-T-153: Experimental Validation and Calculation Benchmark for a Commercial Monte Carlo Pencil Beam Scanning Proton Therapy Treatment Planning System in Water

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lin, L; Huang, S; Kang, M

Purpose: Eclipse proton Monte Carlo AcurosPT 13.7 was commissioned and experimentally validated for an IBA dedicated PBS nozzle in water. Topas 1.3 was used to isolate the cause of differences in output and penumbra between simulation and experiment. Methods: The spot profiles were measured in air at five locations using Lynx. PTW-34070 Bragg peak chamber (Freiburg, Germany) was used to collect the relative integral Bragg peak for 15 proton energies from 100 MeV to 225 MeV. The phase space parameters (σx, σθ, ρxθ) number of protons per MU, energy spread and calculated mean energy provided by AcurosPT were identically implementedmore » into Topas. The absolute dose, profiles and field size factors measured using ionization chamber arrays were compared with both AcurosPT and Topas. Results: The beam spot size, σx, and the angular spread, σθ, in air were both energy-dependent: in particular, the spot size in air at isocentre ranged from 2.8 to 5.3 mm, and the angular spread ranged from 2.7 mrad to 6 mrad. The number of protons per MU increased from ∼9E7 at 100 MeV to ∼1.5E8 at 225 MeV. Both AcurosPT and TOPAS agree with experiment within 2 mm penumbra difference or 3% dose difference for scenarios including central axis depth dose and profiles at two depths in multi-spot square fields, from 40 to 200 mm, for all the investigated single-energy and multi-energy beams, indicating clinically acceptable source model and radiation transport algorithm in water. Conclusion: By comparing measured data and TOPAS simulation using the same source model, the AcurosPT 13.7 was validated in water within 2 mm penumbra difference or 3% dose difference. Benchmarks versus an independent Monte Carlo code are recommended to study the agreement in output, filed size factors and penumbra differences. This project is partially supported by the Varian grant under the master agreement between University of Pennsylvania and Varian.« less

Laser-plasmas in the relativistic-transparency regime: science and applications

DOE PAGES

Fernandez, Juan Carlos; Gautier, Donald Cort; Huang, Chengkun; ...

2017-05-30

Laser-plasma interactions in the novel regime of relativistically induced transparency (RIT) have been harnessed to generate intense ion beams efficiently with average energies exceeding 10 MeV/nucleon (>100 MeV for protons) at “table-top” scales in experiments at the LANL Trident Laser. By further optimization of the laser and target, the RIT regime has been extended into a self-organized plasma mode. This mode yields an ion beam with much narrower energy spread while maintaining high ion energy and conversion efficiency. This mode involves self-generation of persistent high magnetic fields (~10 4 T, according to particle-in-cell simulations of the experiments) at the rear-sidemore » of the plasma. These magnetic fields trap the laser-heated multi-MeV electrons, which generate a high localized electrostatic field (~0.1 TV/m). After the laser exits the plasma, this electric field acts on a highly structured ion-beam distribution in phase space to reduce the energy spread, thus separating acceleration and energy-spread reduction. Thus, ion beams with narrow energy peaks at up to 18 MeV/nucleon are generated reproducibly with high efficiency (≈5%). The experimental demonstration has been done with 0.12 PW, high-contrast, 0.6 ps Gaussian 1.053 μm laser pulses irradiating planar foils up to 250 nm thick at 2–8 × 10 20 W/cm 2. These ion beams with co-propagating electrons have been used on Trident for uniform volumetric isochoric heating to generate and study warm-dense matter at high densities. These beam plasmas have been directed also at a thick Ta disk to generate a directed, intense point-like Bremsstrahlung source of photons peaked at ~2 MeV and used it for point projection radiography of thick high density objects. In addition, prior work on the intense neutron beam driven by an intense deuterium beam generated in the RIT regime has been extended. Neutron spectral control by means of a flexible converter-disk design has been demonstrated, and the neutron beam has been used for point-projection imaging of thick objects. Finally, we discuss the plans and prospects for further improvements and applications.« less

Migration of rice planthoppers and their vectored re-emerging and novel rice viruses in East Asia

PubMed Central

Otuka, Akira

2013-01-01

This review examines recent studies of the migration of three rice planthoppers, Laodelphax striatellus, Sogatella furcifera, and Nilaparvata lugens, in East Asia. Laodelphax striatellus has recently broken out in Jiangsu province, eastern China. The population density in the province started to increase in the early 2000s and peaked in 2004. In 2005, Rice stripe virus (RSV) viruliferous rate of L. striatellus peaked at 31.3%. Since then, rice stripe disease spread severely across the whole province. Due to the migration of the RSV vectors, the rice stripe disease spread to neighboring countries Japan and Korea. An overseas migration of L. striatellus that occurred in 2008 was analyzed, when a slow-moving cold vortex, a type of low pressure system, reached western Japan from Jiangsu, carrying the insects into Japan. Subsequently the rice stripe diseases struck these areas in Japan severely. In Korea, similar situations occurred in 2009, 2011, and 2012. Their migration sources were also estimated to be in Jiangsu by backward trajectory analysis. Rice black-streaked dwarf virus, whose vector is L. striatellus, has recently re-emerged in eastern China, and the evidence for overseas migrations of the virus, just like the RSV’s migrations, has been given. A method of predicting the overseas migration of L. striatellus has been developed by Japanese, Chinese, and Korean institutes. An evaluation of the prediction showed that this method properly predicted migration events that occurred in East Asia from 2008 to 2011. Southern rice black-streaked dwarf virus (SRBSDV) was first found in Guangdong province. Its vector is S. furcifera. An outbreak of SRBSDV occurred in southern China in 2009 and spread to Vietnam the same year. This disease and virus were also found in Japan in 2010. The epidemic triggered many migration studies to investigate concrete spring-summer migration routes in China, and the addition of migration sources for early arrivals in Guangdong and Guangxi have been proposed. Nilaparvata lugens is also an important insect pest of rice. Its migration situations on the Indochina peninsula and return migrations in China are discussed. PMID:24312081

Heterogeneity of Environments Associated with Transmission of Visceral Leishmaniasis in South-Eastern France and Implication for Control Strategies

PubMed Central

Faucher, Benoit; Gaudart, Jean; Faraut, Francoise; Pomares, Christelle; Mary, Charles; Marty, Pierre; Piarroux, Renaud

2012-01-01

Background Visceral leishmaniasis due to Leishmania infantum is currently spreading into new foci across Europe. Leishmania infantum transmission in the Old World was reported to be strongly associated with a few specific environments. Environmental changes due to global warming or human activity were therefore incriminated in the spread of the disease. However, comprehensive studies were lacking to reliably identify all the environments at risk and thereby optimize monitoring and control strategy. Methodology/Findings We exhaustively collected 328 cases of autochthonous visceral leishmaniasis from 1993 to 2009 in South-Eastern France. Leishmaniasis incidence decreased from 31 yearly cases between 1993 and 1997 to 12 yearly cases between 2005 and 2009 mostly because Leishmania/HIV coinfection were less frequent. No spread of human visceral leishmaniasis was observed in the studied region. Two major foci were identified, associated with opposite environments: whereas one involved semi-rural hillside environments partly made of mixed forests, the other involved urban and peri-urban areas in and around the region main town, Marseille. The two neighboring foci were related to differing environments despite similar vectors (P. perniciosus), canine reservoir, parasite (L. infantum zymodeme MON-1), and human host. Conclusions/Significance This unprecedented collection of cases highlighted the occurrence of protracted urban transmission of L. infantum in France, a worrisome finding as the disease is currently spreading in other areas around the Mediterranean. These results complete previous studies about more widespread canine leishmaniasis or human asymptomatic carriage. This first application of systematic geostatistical methods to European human visceral leishmaniasis demonstrated an unsuspected heterogeneity of environments associated with the transmission of the disease. These findings modify the current view of leishmaniasis epidemiology. They notably stress the need for locally defined control strategies and extensive monitoring including in urban environments. PMID:22880142

Heterogeneity of environments associated with transmission of visceral leishmaniasis in South-Eastern France and implication for control strategies.

PubMed

Faucher, Benoit; Gaudart, Jean; Faraut, Francoise; Pomares, Christelle; Mary, Charles; Marty, Pierre; Piarroux, Renaud

2012-01-01

Visceral leishmaniasis due to Leishmania infantum is currently spreading into new foci across Europe. Leishmania infantum transmission in the Old World was reported to be strongly associated with a few specific environments. Environmental changes due to global warming or human activity were therefore incriminated in the spread of the disease. However, comprehensive studies were lacking to reliably identify all the environments at risk and thereby optimize monitoring and control strategy. We exhaustively collected 328 cases of autochthonous visceral leishmaniasis from 1993 to 2009 in South-Eastern France. Leishmaniasis incidence decreased from 31 yearly cases between 1993 and 1997 to 12 yearly cases between 2005 and 2009 mostly because Leishmania/HIV coinfection were less frequent. No spread of human visceral leishmaniasis was observed in the studied region. Two major foci were identified, associated with opposite environments: whereas one involved semi-rural hillside environments partly made of mixed forests, the other involved urban and peri-urban areas in and around the region main town, Marseille. The two neighboring foci were related to differing environments despite similar vectors (P. perniciosus), canine reservoir, parasite (L. infantum zymodeme MON-1), and human host. This unprecedented collection of cases highlighted the occurrence of protracted urban transmission of L. infantum in France, a worrisome finding as the disease is currently spreading in other areas around the Mediterranean. These results complete previous studies about more widespread canine leishmaniasis or human asymptomatic carriage. This first application of systematic geostatistical methods to European human visceral leishmaniasis demonstrated an unsuspected heterogeneity of environments associated with the transmission of the disease. These findings modify the current view of leishmaniasis epidemiology. They notably stress the need for locally defined control strategies and extensive monitoring including in urban environments.

Superior characteristics of microscale light emitting diodes through tightly lateral oxide-confined scheme

NASA Astrophysics Data System (ADS)

Huang, Shen-Che; Li, Heng; Zhang, Zhe-Han; Chen, Hsiang; Wang, Shing-Chung; Lu, Tien-Chang

2017-01-01

We report on the design of the geometry and chip size-controlled structures of microscale light-emitting diodes (micro-LEDs) with a shallow-etched oxide-refilled current aperture and their performance. The proposed structure, which combines an indium-tin-oxide layer and an oxide-confined aperture, exhibited not only uniform current distribution but also remarkably tight current confinement. An extremely high injection level of more than 90 kA/cm2 was achieved in the micro-LED with a 5-μm aperture. Current spreading and the droop mechanism in the investigated devices were characterized through electroluminescence measurements, optical microscopy, and beam-view imaging. Furthermore, we utilized the β-model and S-model to elucidate current crowding and the efficiency droop phenomenon in the investigated micro-LEDs. The luminescence results evidenced the highly favorable performance of the fabricated micro-LEDs, which is a result of their more uniform current spreading and lower junction temperature relative to conventional LEDs. Moreover, the maximum endured current density could be further increased by reducing the aperture size of the micro-LEDs. The proposed design, which is expected to be beneficial for the development of high-performance array-based micro-LEDs, is practicable through current state-of-the-art processing techniques.

The Role of Early-Phase Transmission in the Spread of Yersinia pestis

PubMed Central

EISEN, REBECCA J.; DENNIS, DAVID T.; GAGE, KENNETH L.

2015-01-01

Early-phase transmission (EPT) of Yersinia pestis by unblocked fleas is a well-documented, replicable phenomenon with poorly defined mechanisms. We review evidence demonstrating EPT and current knowledge on its biological and biomechanical processes. We discuss the importance of EPT in the epizootic spread of Y. pestis and its role in the maintenance of plague bacteria in nature. We further address the role of EPT in the epidemiology of plague. PMID:26336267

Identification of Regime Transitions in Umbrella Cloud Growth for Short- and Long-Lived Eruptions

NASA Astrophysics Data System (ADS)

Pouget, S.; Bursik, M. I.; Johnson, C. G.; Hogg, A. J.; Sparks, R. S. J.; Phillips, J.

2014-12-01

The ability to characterize the transition between fluid dynamic regimes in an umbrella cloud as it spreads as a gravity current is important for volcanologists and atmospheric scientists. It would allow a better understanding of how ash behaves and spreads in the atmosphere and therefore better estimate the location and propagation of the ash during an eruption. We tested a new gravity current model that allows us to study the transition from one flow regime to another in data plume growth data from several eruptions. It was found that previous asymptotic models of umbrella cloud growth only treat one part of the evolution of the cloud. The new model allows for the study of the duration of different regimes and the timing of transitions during growth of the umbrella cloud. It was found, by testing the effect of the different input parameters of the model, that the duration of release from the volcanic source has a larger impact than the drag force and the initial radius of the intrusion on the initial and downwind spreading.

The impact of countermeasure propagation on the prevalence of computer viruses.

PubMed

Chen, Li-Chiou; Carley, Kathleen M

2004-04-01

Countermeasures such as software patches or warnings can be effective in helping organizations avert virus infection problems. However, current strategies for disseminating such countermeasures have limited their effectiveness. We propose a new approach, called the Countermeasure Competing (CMC) strategy, and use computer simulation to formally compare its relative effectiveness with three antivirus strategies currently under consideration. CMC is based on the idea that computer viruses and countermeasures spread through two separate but interlinked complex networks-the virus-spreading network and the countermeasure-propagation network, in which a countermeasure acts as a competing species against the computer virus. Our results show that CMC is more effective than other strategies based on the empirical virus data. The proposed CMC reduces the size of virus infection significantly when the countermeasure-propagation network has properties that favor countermeasures over viruses, or when the countermeasure-propagation rate is higher than the virus-spreading rate. In addition, our work reveals that CMC can be flexibly adapted to different uncertainties in the real world, enabling it to be tuned to a greater variety of situations than other strategies.

Anomalous satellite inductive peaks in alternating current response of defective carbon nanotubes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hirai, Daisuke; Watanabe, Satoshi; Yamamoto, Takahiro

2014-05-07

AC response of defective metallic carbon nanotubes is investigated from first principles. We found that capacitive peaks appear at electron scattering states. Moreover, we show that satellite inductive peaks are seen adjacent to a main capacitive peak, which is in contrast to the conductance spectra having no satellite features. The appearance of satellite inductive peaks seems to depend on the scattering states. Our analysis with a simple resonant scattering model reveals that the origin of the satellite inductive peaks can be understood by just one parameter, i.e., the lifetime of electrons at a defect state.

Hydroclimatology of Dual-Peak Annual Cholera Incidence: Insights from a Spatially Explicit Model

NASA Astrophysics Data System (ADS)

Bertuzzo, E.; Mari, L.; Righetto, L.; Gatto, M.; Casagrandi, R.; Rodriguez-Iturbe, I.; Rinaldo, A.

2012-12-01

Cholera incidence in some regions of the Indian subcontinent may exhibit two annual peaks although the main environmental drivers that have been linked to the disease (e.g. sea surface temperature, zooplankton abundance, river discharge) peak once per year during the summer. An empirical hydroclimatological explanation relating cholera transmission to river flows and to the disease spatial spreading has been recently proposed. We specifically support and substantiate mechanistically such hypothesis by means of a spatially explicit model of cholera transmission. Our framework directly accounts for the role of the river network in transporting and redistributing cholera bacteria among human communities as well as for spatial and temporal annual fluctuations of precipitation and river flows. To single out the single out the hydroclimatologic controls on the prevalence patterns in a non-specific geographical context, we first apply the model to Optimal Channel Networks as a general model of hydrological networks. Moreover, we impose a uniform distribution of population. The model is forced by seasonal environmental drivers, namely precipitation, temperature and chlorophyll concentration in the coastal environment, a proxy for Vibrio cholerae concentration. Our results show that these drivers may suffice to generate dual-peak cholera prevalence patterns for proper combinations of timescales involved in pathogen transport, hydrologic variability and disease unfolding. The model explains the possible occurrence of spatial patterns of cholera incidence characterized by a spring peak confined to coastal areas and a fall peak involving inland regions. We then proceed applying the model to the specific settings of Bay of Bengal accounting for the actual river networks (derived from digital terrain map manipulations), the proper distribution of population (estimated from downscaling of census data based on remotely sensed features) and precipitation patterns. Overall our modeling framework suggests insights on how environmental drivers concert the generation of complex spatiotemporal infections and proposes an explanation for the different cholera patterns (dual or single annual peaks) exhibited by regions that share similar hydroclimatological forcings.

SU-E-T-354: Peak Temperature Ratio of TLD Glow Curves to Investigate the Spatial Dependence of LET in a Clinical Proton Beam

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reft, C; Pankuch, M; Ramirez, H

Purpose: Use the ratio of the two high temperature peaks (HTR) in TLD 700 glow curves to investigate spatial dependence of the linear energy transfer (LET) in proton beams. Studies show that the relative biological effectiveness (RBE) depends upon the physical dose as well as its spatial distribution. Although proton therapy uses a spatially invariant RBE of 1.1, studies suggest that the RBE increases in the distal edge of a spread out Bragg peak (SOBP) due to the increased LET. Methods: Glow curve studies in TLD 700 show that the 280 C temperature peak is more sensitive to LET radiationmore » than the 210 C temperature peak. Therefore, the areas under the individual temperature peaks for TLDs irradiated in a proton beam normalized to the peak ratio for 6 MV photons are used to determine the HTR to obtain information on its LET. TLD 700 chips with dimensions 0.31×0.31×0.038 cc are irradiated with 90 MeV protons at varying depths in a specially designed blue wax phantom to investigate LET spatial dependence. Results: Five TLDs were placed at five different depths of the percent depth dose curve (PDD) of range 16.2 cm: center of the SOPB and approximately at the 99% distal edge, 90%, 75% and 25% of the PDD, respectively. HTR was 1.3 at the center of the SOBP and varied from 2.2 to 3.9 which can be related to an LET variation from 0.5 to 18 KeV/μ via calibration with radiation beams of varying LET. Conclusion: HTR data show a spatially invariant LET slightly greater than the 6 MV radiations in the SOBP, but a rapidly increasing LET at the end of the proton range. These results indicate a spatial variation in RBE with potential treatment consequences when selecting treatment margins to minimize the uncertainties in proton RBE.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clayton, James; Shedlock, Daniel; Langeveld, Willem G.J.

Two goals for security scanning of cargo and freight are the ability to determine the type of material that is being imaged, and to do so at low radiation dose. One commonly used technique to determine the effective Z of the cargo is dual-energy imaging, i.e. imaging with different x-ray energy spectra. Another technique uses the fact that the transmitted x-ray spectrum itself also depends on the effective Z. Spectroscopy is difficult because the energy of individual x rays needs to be measured in a very high count-rate environment. Typical accelerators for security applications offer large but short bursts ofmore » x-rays, suitable for current-mode integrated imaging. In order to perform x-ray spectroscopy, a new accelerator design is desired that has the following features: 1) increased duty factor in order to spread out the arrival of x-rays at the detector array over time; 2) x-ray intensity modulation from one delivered pulse to the next by adjusting the accelerator electron beam instantaneous current so as to deliver adequate signal without saturating the spectroscopic detector; and 3) the capability to direct the (forward peaked) x-ray intensity towards high-attenuation areas in the cargo (“fan-beam-steering”). Current sources are capable of 0.1% duty factor, although usually they are operated at significantly lower duty factors (~0.04%), but duty factors in the range 0.4-1.0% are desired. The higher duty factor can be accomplished, e.g., by moving from 300 pulses per second (pps) to 1000 pps and/or increasing the pulse duration from a typical 4 μs to 10 μs. This paper describes initial R&D to examine cost effective modifications that could be performed on a typical accelerator for these purposes, as well as R&D for fan-beam steering.« less

Medulloblastoma initiation and spread: Where neurodevelopment, microenvironment and cancer cross pathways.

PubMed

Martirosian, Vahan; Chen, Thomas C; Lin, Michelle; Neman, Josh

2016-12-01

Medulloblastomas are the most common malignant pediatric brain tumors. Over the past several decades, a wide range of tumor-centric studies have identified genes and their regulators within signaling pathways that promote medulloblastoma growth. This review aims to raise awareness that transdisciplinary research between developmental neurobiology and cancer foundations can advance our current understanding of how the nervous system contributes to medulloblastomas. By leveraging current advances in neurodevelopment, microenvironment (including secreted neuropeptides), neurotransmitters, and axon guidance cues, we can uncover novel mechanisms used by the nervous system to promote medulloblastoma growth and spread. This will ultimately result in development of improved strategies for cancer prevention and treatment of pediatric patients with this devastating disease. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Current perspectives on the dynamics of antibiotic resistance in different reservoirs.

PubMed

Caniça, Manuela; Manageiro, Vera; Jones-Dias, Daniela; Clemente, Lurdes; Gomes-Neves, Eduarda; Poeta, Patrícia; Dias, Elsa; Ferreira, Eugénia

2015-09-01

Antibiotic resistance consists of a dynamic web. In this review, we describe the path by which different antibiotic residues and antibiotic resistance genes disseminate among relevant reservoirs (human, animal, and environmental settings), evaluating how these events contribute to the current scenario of antibiotic resistance. The relationship between the spread of resistance and the contribution of different genetic elements and events is revisited, exploring examples of the processes by which successful mobile resistance genes spread across different niches. The importance of classic and next generation molecular approaches, as well as action plans and policies which might aid in the fight against antibiotic resistance, are also reviewed. Copyright © 2015 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

Fabrication of superconductor-ferromagnet-insulator-superconductor Josephson junctions with critical current uniformity applicable to integrated circuits

NASA Astrophysics Data System (ADS)

Ito, Hiroshi; Taniguchi, Soya; Ishikawa, Kouta; Akaike, Hiroyuki; Fujimaki, Akira

2017-03-01

Nb Josephson junctions (JJs) were fabricated with a Pd89Ni11 ferromagnetic interlayer and an AlO x tunnel barrier layer for use in large-scale superconducting integrated circuits. The junctions had a small critical current (I c) spread, where the standard deviation 1σ was less than 2% at 4.2 K for junctions with the same designed size. It was observed that the electrical behavior of the junctions could be controlled by manipulating the film thickness of the PdNi interlayer. The junctions behaved as a π-JJ for thicknesses of 9 and 11 nm, showing 1σ in the I c spread of 1.2% for 9 nm.

Evaluation of climate model aerosol seasonal and spatial variability over Africa using AERONET

NASA Astrophysics Data System (ADS)

Horowitz, Hannah M.; Garland, Rebecca M.; Thatcher, Marcus; Landman, Willem A.; Dedekind, Zane; van der Merwe, Jacobus; Engelbrecht, Francois A.

2017-11-01

The sensitivity of climate models to the characterization of African aerosol particles is poorly understood. Africa is a major source of dust and biomass burning aerosols and this represents an important research gap in understanding the impact of aerosols on radiative forcing of the climate system. Here we evaluate the current representation of aerosol particles in the Conformal Cubic Atmospheric Model (CCAM) with ground-based remote retrievals across Africa, and additionally provide an analysis of observed aerosol optical depth at 550 nm (AOD550 nm) and Ångström exponent data from 34 Aerosol Robotic Network (AERONET) sites. Analysis of the 34 long-term AERONET sites confirms the importance of dust and biomass burning emissions to the seasonal cycle and magnitude of AOD550 nm across the continent and the transport of these emissions to regions outside of the continent. In general, CCAM captures the seasonality of the AERONET data across the continent. The magnitude of modeled and observed multiyear monthly average AOD550 nm overlap within ±1 standard deviation of each other for at least 7 months at all sites except the Réunion St Denis Island site (Réunion St. Denis). The timing of modeled peak AOD550 nm in southern Africa occurs 1 month prior to the observed peak, which does not align with the timing of maximum fire counts in the region. For the western and northern African sites, it is evident that CCAM currently overestimates dust in some regions while others (e.g., the Arabian Peninsula) are better characterized. This may be due to overestimated dust lifetime, or that the characterization of the soil for these areas needs to be updated with local information. The CCAM simulated AOD550 nm for the global domain is within the spread of previously published results from CMIP5 and AeroCom experiments for black carbon, organic carbon, and sulfate aerosols. The model's performance provides confidence for using the model to estimate large-scale regional impacts of African aerosols on radiative forcing, but local feedbacks between dust aerosols and climate over northern Africa and the Mediterranean may be overestimated.

High-accuracy peak picking of proteomics data using wavelet techniques.

PubMed

Lange, Eva; Gröpl, Clemens; Reinert, Knut; Kohlbacher, Oliver; Hildebrandt, Andreas

2006-01-01

A new peak picking algorithm for the analysis of mass spectrometric (MS) data is presented. It is independent of the underlying machine or ionization method, and is able to resolve highly convoluted and asymmetric signals. The method uses the multiscale nature of spectrometric data by first detecting the mass peaks in the wavelet-transformed signal before a given asymmetric peak function is fitted to the raw data. In an optional third stage, the resulting fit can be further improved using techniques from nonlinear optimization. In contrast to currently established techniques (e.g. SNAP, Apex) our algorithm is able to separate overlapping peaks of multiply charged peptides in ESI-MS data of low resolution. Its improved accuracy with respect to peak positions makes it a valuable preprocessing method for MS-based identification and quantification experiments. The method has been validated on a number of different annotated test cases, where it compares favorably in both runtime and accuracy with currently established techniques. An implementation of the algorithm is freely available in our open source framework OpenMS.

Three years of lightning impulse charge moment change measurements in the United States

NASA Astrophysics Data System (ADS)

Cummer, Steven A.; Lyons, Walter A.; Stanley, Mark A.

2013-06-01

We report and analyze 3 years of lightning impulse charge moment change (iCMC) measurements obtained from an automated, real time lightning charge moment change network (CMCN). The CMCN combines U.S. National Lightning Detection Network (NLDN) lightning event geolocations with extremely low frequency (≲1 kHz) data from two stations to provide iCMC measurements across the entire United States. Almost 14 million lightning events were measured in the 3 year period. We present the statistical distributions of iCMC versus polarity and NLDN-measured peak current, including corrections for the detection efficiency of the CMCN versus peak current. We find a broad distribution of iCMC for a given peak current, implying that these parameters are at best only weakly correlated. Curiously, the mean iCMC does not monotonically increase with peak current, and in fact, drops for positive CG strokes above +150 kA. For all positive strokes, there is a boundary near 20 C km that separates seemingly distinct populations of high and low iCMC strokes. We also explore the geographic distribution of high iCMC lightning strokes. High iCMC positive strokes occur predominantly in the northern midwest portion of the U.S., with a secondary peak over the gulf stream region just off the U.S. east coast. High iCMC negative strokes are also clustered in the midwest, although somewhat south of most of the high iCMC positive strokes. This is a region far from the locations of maximum occurrence of high peak current negative strokes. Based on assumed iCMC thresholds for sprite production, we estimate that approximately 35,000 positive polarity and 350 negative polarity sprites occur per year over the U.S. land and near-coastal areas. Among other applications, this network is useful for the nowcasting of sprite-producing storms and storm regions.

Developing physics basis for the snowflake divertor in the DIII-D tokamak

DOE PAGES

Soukhanovskii, V. A.; Allen, S. L.; Fenstermacher, M. E.; ...

2018-02-01

Recent DIII-D results demonstrate that the snowflake (SF) divertor geometry (cf. standard divertor) enables significant manipulation of divertor heat transport for heat spreading and reduction in attached and radiative divertor regimes, between and during edge localized modes (ELMs), while maintaining good H-mode confinement. Snowflake divertor configurations have been realized in the DIII-D tokamak for several seconds in H-mode discharges with heating power PNBImore » $$\\leqslant$$ 4-5 MW and a range of plasma currents Ip = 0.8-1.2 MA. In this work, inter-ELM transport and radiative SF divertor properties are studied. Significant impact of geometric properties on SOL and divertor plasma parameters, including increased poloidal magnetic flux expansion, divertor magnetic field line length and divertor volume, is confirmed. In the SF-minus configuration, heat deposition is affected by the geometry, and peak divertor heat fluxes are significantly reduced. In the SF-plus and near-exact SF configurations, divertor peak heat flux reduction and outer strike point heat flux profile broadening are observed. Inter-ELM sharing of power and particle fluxes between the main and additional snowflake divertor strike points has been demonstrated. The additional strike points typically receive up to 10-15% of total outer divertor power. Measurements of electron pressure and poloidal beta !p support the theoretically proposed churning mode that is driven by toroidal curvature and vertical pressure gradient in the weak poloidal field region. A comparison of the 4-4.5 MW NBI-heated H-mode plasmas with radiative SF divertor and the standard radiative divertor (both induced with additional gas puffing) shows a nearly complete power detachment and broader divertor radiated power distribution in the SF, as compared to a partial detachment and peaked localized radiation in the standard divertor. However, insignificant difference in the detachment onset w.r.t. density between the SF and the standard divertor was found. The results complement the initial SF divertor studies in the NSTX and DIII-D tokamaks and contribute to the physics basis of the SF divertor as a power exhaust concept for future tokamaks.« less

Developing physics basis for the snowflake divertor in the DIII-D tokamak

DOE Office of Scientific and Technical Information (OSTI.GOV)

Soukhanovskii, V. A.; Allen, S. L.; Fenstermacher, M. E.

Recent DIII-D results demonstrate that the snowflake (SF) divertor geometry (cf. standard divertor) enables significant manipulation of divertor heat transport for heat spreading and reduction in attached and radiative divertor regimes, between and during edge localized modes (ELMs), while maintaining good H-mode confinement. Snowflake divertor configurations have been realized in the DIII-D tokamak for several seconds in H-mode discharges with heating power PNBImore » $$\\leqslant$$ 4-5 MW and a range of plasma currents Ip = 0.8-1.2 MA. In this work, inter-ELM transport and radiative SF divertor properties are studied. Significant impact of geometric properties on SOL and divertor plasma parameters, including increased poloidal magnetic flux expansion, divertor magnetic field line length and divertor volume, is confirmed. In the SF-minus configuration, heat deposition is affected by the geometry, and peak divertor heat fluxes are significantly reduced. In the SF-plus and near-exact SF configurations, divertor peak heat flux reduction and outer strike point heat flux profile broadening are observed. Inter-ELM sharing of power and particle fluxes between the main and additional snowflake divertor strike points has been demonstrated. The additional strike points typically receive up to 10-15% of total outer divertor power. Measurements of electron pressure and poloidal beta !p support the theoretically proposed churning mode that is driven by toroidal curvature and vertical pressure gradient in the weak poloidal field region. A comparison of the 4-4.5 MW NBI-heated H-mode plasmas with radiative SF divertor and the standard radiative divertor (both induced with additional gas puffing) shows a nearly complete power detachment and broader divertor radiated power distribution in the SF, as compared to a partial detachment and peaked localized radiation in the standard divertor. However, insignificant difference in the detachment onset w.r.t. density between the SF and the standard divertor was found. The results complement the initial SF divertor studies in the NSTX and DIII-D tokamaks and contribute to the physics basis of the SF divertor as a power exhaust concept for future tokamaks.« less

Re-emergence of Cholera in the Americas: Risks, Susceptibility, and Ecology

PubMed Central

Poirier, Mathieu JP; Izurieta, Ricardo; Malavade, Sharad S; McDonald, Michael D

2012-01-01

Background: The re-emergence of cholera in Haiti has established a new reservoir for the seventh cholera pandemic which threatens to spread to other countries in the Americas. Materials and Methods: Statistics from this new epidemic are compared to the 1991 Peru epidemic, which demonstrated the speed and complexity with which this disease can spread from country to country. Environmental factors implicated in the spread of Vibrio cholerae such as ocean currents and temperatures, as well as biotic factors from zooplankton to waterfowl pose a risk for many countries in the Americas. Results: The movement of people and goods from Hispaniola are mostly destined for North America, but occur to some degree throughout the Americas. These modes of transmission, and the probability of uncontrolled community spread beyond Hispaniola, however, are completely dependent upon risk factors within these countries such as water quality and availability of sanitation. Although North America has excellent coverage of these deterrents to the spread of infectious gastrointestinal diseases, many countries throughout Latin America and the Caribbean lack these basic services and infrastructures. Conclusions: In order to curb the immediate spread of cholera in Hispaniola, treatment availability should be expanded to all parts of the island and phase II epidemic management initiatives must be developed. PMID:23055647

Analysis of the Diurnal Variation of the Global Electric Circuit Obtained From Different Numerical Models

NASA Astrophysics Data System (ADS)

Jánský, Jaroslav; Lucas, Greg M.; Kalb, Christina; Bayona, Victor; Peterson, Michael J.; Deierling, Wiebke; Flyer, Natasha; Pasko, Victor P.

2017-12-01

This work analyzes different current source and conductivity parameterizations and their influence on the diurnal variation of the global electric circuit (GEC). The diurnal variations of the current source parameterizations obtained using electric field and conductivity measurements from plane overflights combined with global Tropical Rainfall Measuring Mission satellite data give generally good agreement with measured diurnal variation of the electric field at Vostok, Antarctica, where reference experimental measurements are performed. An approach employing 85 GHz passive microwave observations to infer currents within the GEC is compared and shows the best agreement in amplitude and phase with experimental measurements. To study the conductivity influence, GEC models solving the continuity equation in 3-D are used to calculate atmospheric resistance using yearly averaged conductivity obtained from the global circulation model Community Earth System Model (CESM). Then, using current source parameterization combining mean currents and global counts of electrified clouds, if the exponential conductivity is substituted by the conductivity from CESM, the peak to peak diurnal variation of the ionospheric potential of the GEC decreases from 24% to 20%. The main reason for the change is the presence of clouds while effects of 222Rn ionization, aerosols, and topography are less pronounced. The simulated peak to peak diurnal variation of the electric field at Vostok is increased from 15% to 18% from the diurnal variation of the global current in the GEC if conductivity from CESM is used.

Televangelism and the Rhetoric of Exclusion.

ERIC Educational Resources Information Center

Rosenthal, Robert E.

Included in the many problems of current televangelism which are cause for concern are the constant appeals for donations. Under current circumstances, with tremendous sums of money needed to use television for religious purposes, televangelists resort to sensationalism for mass appeal rather than to spreading the gospel. This ethical problem…

Wind-Tunnel Experiments for Gas Dispersion in an Atmospheric Boundary Layer with Large-Scale Turbulent Motion

NASA Astrophysics Data System (ADS)

Michioka, Takenobu; Sato, Ayumu; Sada, Koichi

2011-10-01

Large-scale turbulent motions enhancing horizontal gas spread in an atmospheric boundary layer are simulated in a wind-tunnel experiment. The large-scale turbulent motions can be generated using an active grid installed at the front of the test section in the wind tunnel, when appropriate parameters for the angular deflection and the rotation speed are chosen. The power spectra of vertical velocity fluctuations are unchanged with and without the active grid because they are strongly affected by the surface. The power spectra of both streamwise and lateral velocity fluctuations with the active grid increase in the low frequency region, and are closer to the empirical relations inferred from field observations. The large-scale turbulent motions do not affect the Reynolds shear stress, but change the balance of the processes involved. The relative contributions of ejections to sweeps are suppressed by large-scale turbulent motions, indicating that the motions behave as sweep events. The lateral gas spread is enhanced by the lateral large-scale turbulent motions generated by the active grid. The large-scale motions, however, do not affect the vertical velocity fluctuations near the surface, resulting in their having a minimal effect on the vertical gas spread. The peak concentration normalized using the root-mean-squared value of concentration fluctuation is remarkably constant over most regions of the plume irrespective of the operation of the active grid.

Shallow velocity structure across the Mariana arc

NASA Astrophysics Data System (ADS)

Tait, S.; Kaminski, E. C.; Carazzo, G.; Limare, A.

2016-12-01

Atmospheric injection of volcanic ash during explosive eruptions is controlled by the dynamics of a volcanic column and associated umbrella cloud, which are subject to a wind field, and are connected by a turbulent fountain which initiates horizontal spreading at the neutral buoyancy level. We present a new theoretical and experimental study of an axisymmetric turbulent umbrella cloud intruding horizontally at its neutral buoyancy level into a static environment linearly stratified in density. The intrusion is fed by a constant horizontal volume flux (Q0) at a finite radius (R0), where it has a constant thickness (2H0). The characteristics of the fountain (R0, H0, Q0) derive from a vertical forced plume (source momentum and buoyancy fluxes Mi , Fi) and environmental stratification N. Buoyancy drives horizontal flow but, despite high Reynolds number, impedes entrainment of ambient fluid into the umbrella cloud. Turbulent stresses are nevertheless crucial in the momentum balance. Our theory highlights the vertical profiles of density and velocity within the current of which we present experimental measurements. Initially, current buoyancy is opposed by the inertia of the ambient fluid, and current radius (RN(t)) grows linearly in time. Subsequently, turbulent drag opposes buoyancy, and the current breaks down into two parts: i) between the source and a transition radius (R0T(t)), a steady region where current thickness (2H) and mean velocity (U) are time-independent and decreasing functions of r ; ii), a contiguous unsteady « frontal » region, between the transition radius and the front (RTN), in which the current thickens. The theory predicts current shape and an asymptotic spreading behaviour (RN t^5/9) which agree well with experimental data. Our analysis of satellite observations of several sustained plinian events including the Pinatubo 1991 climactic eruption shows that both the initial and asymptotic spreading regimes predicted by the model are present.

The Dynamics of Volcanic Umbrella Clouds

NASA Astrophysics Data System (ADS)

Tait, S.; Kaminski, E. C.; Carazzo, G.; Limare, A.

2017-12-01

Atmospheric injection of volcanic ash during explosive eruptions is controlled by the dynamics of a volcanic column and associated umbrella cloud, which are subject to a wind field, and are connected by a turbulent fountain which initiates horizontal spreading at the neutral buoyancy level. We present a new theoretical and experimental study of an axisymmetric turbulent umbrella cloud intruding horizontally at its neutral buoyancy level into a static environment linearly stratified in density. The intrusion is fed by a constant horizontal volume flux (Q0) at a finite radius (R0), where it has a constant thickness (2H0). The characteristics of the fountain (R0, H0, Q0) derive from a vertical forced plume (source momentum and buoyancy fluxes Mi , Fi) and environmental stratification N. Buoyancy drives horizontal flow but, despite high Reynolds number, impedes entrainment of ambient fluid into the umbrella cloud. Turbulent stresses are nevertheless crucial in the momentum balance. Our theory highlights the vertical profiles of density and velocity within the current of which we present experimental measurements. Initially, current buoyancy is opposed by the inertia of the ambient fluid, and current radius (RN(t)) grows linearly in time. Subsequently, turbulent drag opposes buoyancy, and the current breaks down into two parts: i) between the source and a transition radius (R0T(t)), a steady region where current thickness (2H) and mean velocity (U) are time-independent and decreasing functions of r ; ii), a contiguous unsteady « frontal » region, between the transition radius and the front (RTN), in which the current thickens. The theory predicts current shape and an asymptotic spreading behaviour (RN t^5/9) which agree well with experimental data. Our analysis of satellite observations of several sustained plinian events including the Pinatubo 1991 climactic eruption shows that both the initial and asymptotic spreading regimes predicted by the model are present.

A genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemic

PubMed Central

Holden, Matthew T.G.; Hsu, Li-Yang; Kurt, Kevin; Weinert, Lucy A.; Mather, Alison E.; Harris, Simon R.; Strommenger, Birgit; Layer, Franziska; Witte, Wolfgang; de Lencastre, Herminia; Skov, Robert; Westh, Henrik; Žemličková, Helena; Coombs, Geoffrey; Kearns, Angela M.; Hill, Robert L.R.; Edgeworth, Jonathan; Gould, Ian; Gant, Vanya; Cooke, Jonathan; Edwards, Giles F.; McAdam, Paul R.; Templeton, Kate E.; McCann, Angela; Zhou, Zhemin; Castillo-Ramírez, Santiago; Feil, Edward J.; Hudson, Lyndsey O.; Enright, Mark C.; Balloux, Francois; Aanensen, David M.; Spratt, Brian G.; Fitzgerald, J. Ross; Parkhill, Julian; Achtman, Mark; Bentley, Stephen D.; Nübel, Ulrich

2013-01-01

The widespread use of antibiotics in association with high-density clinical care has driven the emergence of drug-resistant bacteria that are adapted to thrive in hospitalized patients. Of particular concern are globally disseminated methicillin-resistant Staphylococcus aureus (MRSA) clones that cause outbreaks and epidemics associated with health care. The most rapidly spreading and tenacious health-care-associated clone in Europe currently is EMRSA-15, which was first detected in the UK in the early 1990s and subsequently spread throughout Europe and beyond. Using phylogenomic methods to analyze the genome sequences for 193 S. aureus isolates, we were able to show that the current pandemic population of EMRSA-15 descends from a health-care-associated MRSA epidemic that spread throughout England in the 1980s, which had itself previously emerged from a primarily community-associated methicillin-sensitive population. The emergence of fluoroquinolone resistance in this EMRSA-15 subclone in the English Midlands during the mid-1980s appears to have played a key role in triggering pandemic spread, and occurred shortly after the first clinical trials of this drug. Genome-based coalescence analysis estimated that the population of this subclone over the last 20 yr has grown four times faster than its progenitor. Using comparative genomic analysis we identified the molecular genetic basis of 99.8% of the antimicrobial resistance phenotypes of the isolates, highlighting the potential of pathogen genome sequencing as a diagnostic tool. We document the genetic changes associated with adaptation to the hospital environment and with increasing drug resistance over time, and how MRSA evolution likely has been influenced by country-specific drug use regimens. PMID:23299977

Acetylcholine-activated ionic currents in parasympathetic neurons of bullfrog heart.

PubMed

Tateishi, N; Kim, D K; Akaike, N

1990-05-01

1. The electrical and pharmacologic properties of acetylcholine (ACh)-induced current (IACh) were studied in the parasympathetic neurons isolated from bullfrog heart with the use of the concentration-clamp technique, which allows intracellular perfusion and rapid change of external solution within 2 ms under the single-electrode voltage-clamp condition. 2. The IACh consisted of an initial transient peak component and a successive steady-state plateau component. Both currents increased in a sigmoidal fashion with increasing ACh concentration. The dissociation constant (Kd value) and the Hill coefficient for each component were 2.2 X 10(-5) M and 1.6, respectively. 3. In the K(+)-free solution, the reversal potential (EACh) of IACh was close to the Na+ equilibrium potential (ENa). The current-voltage (I-V) relation showed inward rectification at positive potentials. 4. Nicotine mimicked only the peak component of IACh. However both peak and steady-state components were blocked nonselectively by the nicotinic blockers d-tubocurarine and hexamethonium. 5. Carbamylcholine (CCh) mimicked the steady-state component of IACh. The steady-state component was selectively inhibited by atropine at concentrations 1,000 times lower than that required for inhibition of the peak component. The steady state was blocked equally by either pirenzepine (M1 blocker) or AF-DX-116 (M2 blocker). 6. It was concluded that the IACh consisted of a peak component having double exponential activation and inactivation, mediated through the nicotinic actions, and a steady-state component having no inactivation, mediated through the muscarinic action.

Trap-assisted tunneling in Si-InAs nanowire heterojunction tunnel diodes.

PubMed

Bessire, Cedric D; Björk, Mikael T; Schmid, Heinz; Schenk, Andreas; Reuter, Kathleen B; Riel, Heike

2011-10-12

We report on the electrical characterization of one-sided p(+)-si/n-InAs nanowire heterojunction tunnel diodes to provide insight into the tunnel process occurring in this highly lattice mismatched material system. The lattice mismatch gives rise to dislocations at the interface as confirmed by electron microscopy. Despite this, a negative differential resistance with peak-to-valley current ratios of up to 2.4 at room temperature and with large current densities is observed, attesting to the very abrupt and high-quality interface. The presence of dislocations and other defects that increase the excess current is evident in the first and second derivative of the I-V characteristics as distinct peaks arising from trap-and phonon-assisted tunneling via the corresponding defect levels. We observe this assisted tunneling mainly in the forward direction and at low reverse bias but not at higher reverse biases because the band-to-band generation rates are peaked in the InAs, which is also confirmed by modeling. This indicates that most of the peaks are due to dislocations and defects in the immediate vicinity of the interface. Finally, we also demonstrate that these devices are very sensitive to electrical stress, in particular at room temperature, because of the extremely high electrical fields obtained at the abrupt junction even at low bias. The electrical stress induces additional defect levels in the band gap, which reduce the peak-to-valley current ratios.