Agonist-biased Trafficking of Somatostatin Receptor 2A in Enteric Neurons*

PubMed Central

Zhao, Peishen; Canals, Meritxell; Murphy, Jane E.; Klingler, Diana; Eriksson, Emily M.; Pelayo, Juan-Carlos; Hardt, Markus; Bunnett, Nigel W.; Poole, Daniel P.

2013-01-01

Somatostatin (SST) 14 and SST 28 activate somatostatin 2A receptors (SSTR2A) on enteric neurons to control gut functions. SST analogs are treatments of neuroendocrine and bleeding disorders, cancer, and diarrhea, with gastrointestinal side effects of constipation, abdominal pain, and nausea. How endogenous agonists and drugs differentially regulate neuronal SSTR2A is unexplored. We evaluated SSTR2A trafficking in murine myenteric neurons and neuroendocrine AtT-20 cells by microscopy and determined whether agonist degradation by endosomal endothelin-converting enzyme 1 (ECE-1) controls SSTR2A trafficking and association with β-arrestins, key regulators of receptors. SST-14, SST-28, and peptide analogs (octreotide, lanreotide, and vapreotide) stimulated clathrin- and dynamin-mediated internalization of SSTR2A, which colocalized with ECE-1 in endosomes and the Golgi. After incubation with SST-14, SSTR2A recycled to the plasma membrane, which required active ECE-1 and an intact Golgi. SSTR2A activated by SST-28, octreotide, lanreotide, or vapreotide was retained within the Golgi and did not recycle. Although ECE-1 rapidly degraded SST-14, SST-28 was resistant to degradation, and ECE-1 did not degrade SST analogs. SST-14 and SST-28 induced transient interactions between SSTR2A and β-arrestins that were stabilized by an ECE-1 inhibitor. Octreotide induced sustained SSTR2A/β-arrestin interactions that were not regulated by ECE-1. Thus, when activated by SST-14, SSTR2A internalizes and recycles via the Golgi, which requires ECE-1 degradation of SST-14 and receptor dissociation from β-arrestins. After activation by ECE-1-resistant SST-28 and analogs, SSTR2A remains in endosomes because of sustained β-arrestin interactions. Therapeutic SST analogs are ECE-1-resistant and retain SSTR2A in endosomes, which may explain their long-lasting actions. PMID:23913690

Large-scale effects on the regulation of tropical sea surface temperature

NASA Technical Reports Server (NTRS)

Hartmann, Dennis L.; Michelsen, Marc L.

1993-01-01

The dominant terms in the surface energy budget of the tropical oceans are absorption of solar radiation and evaporative cooling. If it is assumed that relative humidity in the boundary layer remains constant, evaporative cooling will increase rapidly with sea surface temperature (SST) because of the strong temperature dependence of saturation water vapor pressure. The resulting stabilization of SST provided by evaporative cooling is sufficient to overcome positive feedback contributed by the decrease of surface net longwave cooling with increasing SST. Evaporative cooling is sensitive to small changes in boundary-layer relative humidity. Large and negative shortwave cloud forcing in the regions of highest SST are supported by the moisture convergence associated with largescale circulations. In the descending portions of these circulations the shortwave cloud forcing is suppressed. When the effect of these circulations is taken into account by spatial averaging, the area-averaged cloud forcing shows no sensitivity to area-averaged SST changes associated with the 1987 warming event in the tropical Pacific. While the shortwave cloud forcing is large and important in the convective regions, the importance of its role in regulating the average temperature of the tropics and in modulating temperature gradients within the tropics is less clear. A heuristic model of SST is used to illustrate the possible role of large-scale atmospheric circulations on SST in the tropics and the coupling between SST gradients and mean tropical SST. The intensity of large-scale circulations responds sensitivity to SST gradients and affects the mean tropical SST by supplying dry air to the planetary boundary layer. Large SST gradients generate vigorous circulations that increase evaporation and reduce the mean SST.

Interim Stabilization Equipment Essential and Support Drawing Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

KOCH, M.R.

The purpose of this document is to list the Interim Stabilization equipment drawings that are classified as Essential or Support drawings. Essential Drawings: Those drawings identified by the facility staff as necessary to directly support the safe operation of the facility or equipment. Support Drawings: Those drawings identified by the facility staff that further describe the design details of structures, systems or components shown on essential drawings.

NASA's High Speed Research Program - An introduction and status report

NASA Technical Reports Server (NTRS)

Wesoky, Howard L.; Prather, Michael J.; Kayten, Gerald G.

1990-01-01

NASA's High Speed Research Program (HSRP) gives attention to the potential environmental effects of a next-generation SST in three areas of concern: atmospheric pollution, airport community noise, and sonic boom. Research has accordingly been undertaken in such fields as the validation of ozone depletion predictions, the feasibility a 90-percent NO(x) emissions reduction to minimize ozone-layer impacts, economically viable compliance with FAR 36 Stage 3 airport community noise levels, and the comparative advantages of efficient subsonic flight over land masses or low-sonic-boom-optimized configurations. Interim HSRP milestones for 1991 and 1992 are noted.

77 FR 31374 - Notice of Submission of Proposed Information Collection to OMB; Rural Housing Stability Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-25

... through the HEARTH Act. The statutory provisions and the implementing interim regulations that govern RHSP... HEARTH Act. The statutory provisions and the implementing interim regulations that govern RHSP require...

Secular spring rainfall variability at local scale over Ethiopia: trend and associated dynamics

NASA Astrophysics Data System (ADS)

Tsidu, Gizaw Mengistu

2017-10-01

Spring rainfall secular variability is studied using observations, reanalysis, and model simulations. The joint coherent spatio-temporal secular variability of gridded monthly gauge rainfall over Ethiopia, ERA-Interim atmospheric variables and sea surface temperature (SST) from Hadley Centre Sea Ice and SST (HadISST) data set is extracted using multi-taper method singular value decomposition (MTM-SVD). The contemporaneous associations are further examined using partial Granger causality to determine presence of causal linkage between any of the climate variables. This analysis reveals that only the northwestern Indian Ocean secular SST anomaly has direct causal links with spring rainfall over Ethiopia and mean sea level pressure (MSLP) over Africa inspite of the strong secular covariance of spring rainfall, SST in parts of subtropical Pacific, Atlantic, Indian Ocean and MSLP. High secular rainfall variance and statistically significant linear trend show consistently that there is a massive decline in spring rain over southern Ethiopia. This happened concurrently with significant buildup of MSLP over East Africa, northeastern Africa including parts of the Arabian Peninsula, some parts of central Africa and SST warming over all ocean basins with the exception of the ENSO regions. The east-west pressure gradient in response to the Indian Ocean warming led to secular southeasterly winds over the Arabian Sea, easterly over central Africa and equatorial Atlantic. These flows weakened climatological northeasterly flow over the Arabian Sea and southwesterly flow over equatorial Atlantic and Congo basins which supply moisture into the eastern Africa regions in spring. The secular divergent flow at low level is concurrent with upper level convergence due to the easterly secular anomalous flow. The mechanisms through which the northwestern Indian Ocean secular SST anomaly modulates rainfall are further explored in the context of East Africa using a simplified atmospheric general circulation model (AGCM) coupled to mixed-layer oceanic model. The rainfall anomaly (with respect to control simulation), forced by the northwestern Indian Ocean secular SST anomaly and averaged over the 30-year period, exhibits prevalence of dry conditions over East and equatorial Africa in agreement with observation. The atmospheric response to secular SST warming anomaly led to divergent flow at low levels and subsidence at the upper troposphere over regions north of 5° S on the continent and vice versa over the Indian Ocean. This surface difluence over East Africa, in addition to its role in suppressing convective activity, deprives the region of moisture supply from the Indian Ocean as well as the Atlantic and Congo basins.

Causes and Consequences of Exceptional North Atlantic Heat Loss in Recent Winters

NASA Astrophysics Data System (ADS)

Josey, Simon; Grist, Jeremy; Duchez, Aurelie; Frajka-Williams, Eleanor; Hirschi, Joel; Marsh, Robert; Sinha, Bablu

2016-04-01

The mid-high latitude North Atlantic loses large amounts of heat to the atmosphere in winter leading to dense water formation. An examination of reanalysis datasets (ERA-Interim, NCEP/NCAR) reveals that heat loss in the recent winters 2013-14 and 2014-15 was exceptionally strong. The causes and consequences of this extraordinary ocean heat loss will be discussed. In 2013-2014, the net air-sea heat flux anomaly averaged over the whole winter exceeded 100 Wm-2 in the eastern subpolar gyre (the most extreme in the period since 1979 spanned by ERA-Interim). The causes of this extreme heat loss will be shown to be severe latent and sensible heat fluxes driven primarily by anomalously strong westerly airflows from North America and northerly airflows originating in the Nordic Seas. The associated sea level pressure anomaly field reflects the dominance of the second mode of atmospheric variability, the East Atlantic Pattern (EAP) over the North Atlantic Oscillation (NAO) in this winter. The extreme winter heat loss had a significant impact on the ocean extending from the sea surface into the deeper layers and a re-emergent cold Sea Surface Temperature (SST) anomaly is evident in November 2014. The following winter 2014-15 experienced further extreme heat loss that served to amplify the strength of the re-emergent SST anomaly. By summer 2015, an unprecedented cold mid-latitude North Atlantic Ocean surface temperature anomaly is evident in observations and has been widely referred to as the 'big blue blob'. The role played by the extreme surface heat loss in the preceding winters in generating this feature and it subsequent evolution through winter 2015-16 will be explored.

Quality control of FWC during assembly and commissioning in SST-1 Tokamak

NASA Astrophysics Data System (ADS)

Patel, Hitesh; Santra, Prosenjit; Parekh, Tejas; Biswas, Prabal; Jayswal, Snehal; Chauhan, Pradeep; Paravastu, Yuvakiran; George, Siju; Semwal, Pratibha; Thankey, Prashant; Ramesh, Gattu; Prakash, Arun; Dhanani, Kalpesh; Raval, D. C.; Khan, Ziauddin; Pradhan, Subrata

2017-04-01

First Wall Components (FWC) of SST-1 tokamak, which are in the immediate vicinity of plasma, comprises of limiters, divertors, baffles, passive stabilizers designed to operate long duration (∼1000 s) discharges of elongated plasma. All FWC consist of copper alloy heat sink modules with SS cooling tubes brazed onto it, graphite tiles acting as armour material facing the plasma, and are mounted to the vacuum vessels with suitable Inconel support structures at inter-connected ring & port locations. The FWC are very recently assembled and commissioned successfully inside the vacuum vessel of SST-1 undergoing a rigorous quality control and checks at every stage of the assembly process. This paper will present the quality control aspects and checks of FWC from commencement of assembly procedure, namely material test reports, leak testing of high temperature baked components, assembled dimensional tolerances, leak testing of all welded joints, graphite tile tightening torques, electrical continuity and electrical isolation of passive stabilizers from vacuum vessel, baking and cooling hydraulic connections inside vacuum vessel.

A case study of sea breeze blocking regulated by sea surface temperature along the English south coast

NASA Astrophysics Data System (ADS)

Sweeney, J. K.; Chagnon, J. M.; Gray, S. L.

2013-09-01

The sensitivity of sea breeze structure to sea surface temperature (SST) and coastal orography is investigated in convection-permitting Met Office Unified Model simulations of a case study along the south coast of England. Changes in SST of 1 K are shown to significantly modify the structure of the sea breeze. On the day of the case study the sea breeze was partially blocked by coastal orography, particularly within Lyme Bay. The extent to which the flow is blocked depends strongly on the static stability of the marine boundary layer. In experiments with colder SST, the marine boundary layer is more stable, and the degree of blocking is more pronounced. The implications of prescribing fixed SST from climatology in numerical weather prediction model forecasts of the sea breeze are discussed.

Sensitivity of Offshore Surface Fluxes and Sea Breezes to the Spatial Distribution of Sea-Surface Temperature

NASA Astrophysics Data System (ADS)

Lombardo, Kelly; Sinsky, Eric; Edson, James; Whitney, Michael M.; Jia, Yan

2018-03-01

A series of numerical sensitivity experiments is performed to quantify the impact of sea-surface temperature (SST) distribution on offshore surface fluxes and simulated sea-breeze dynamics. The SST simulations of two mid-latitude sea-breeze events over coastal New England are performed using a spatially-uniform SST, as well as spatially-varying SST datasets of 32- and 1-km horizontal resolutions. Offshore surface heat and buoyancy fluxes vary in response to the SST distribution. Local sea-breeze circulations are relatively insensitive, with minimal differences in vertical structure and propagation speed among the experiments. The largest thermal perturbations are confined to the lowest 10% of the sea-breeze column due to the relatively high stability of the mid-Atlantic marine atmospheric boundary layer (ABL) suppressing vertical mixing, resulting in the depth of the marine layer remaining unchanged. Minimal impacts on the column-averaged virtual potential temperature and sea-breeze depth translates to small changes in sea-breeze propagation speed. This indicates that the use of datasets with a fine-scale SST may not produce more accurate sea-breeze simulations in highly stable marine ABL regimes, though may prove more beneficial in less stable sub-tropical environments.

Asymmetric Response of the Equatorial Pacific SST to Climate Warming and Cooling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Fukai; Luo, Yiyong; Lu, Jian

The response of the equatorial Pacific Ocean to heat fluxes of equal amplitude but opposite sign is investigated using the Community Earth System Model (CESM). Results show a strong asymmetry in SST changes. In the eastern equatorial Pacific (EEP), the warming responding to the positive forcing exceeds the cooling to the negative forcing; while in the western equatorial Pacific (WEP), it is the other way around and the cooling surpasses the warming. This leads to a zonal dipole asymmetric structure, with positive values in the east and negative values in the west. A surface heat budget analysis suggests that themore » SST asymmetry is mainly resulted from the oceanic horizontal advection and vertical entrainment, with both of their linear and nonlinear components playing a role. For the linear component, its change appears to be more significant over the EEP (WEP) in the positive (negative) forcing scenario, favoring the seesaw pattern of the SST asymmetry. For the nonlinear component, its change acts to warm (cool) the EEP (WEP) in both scenarios, also favorable for the development of the SST asymmetry. Additional experiments with a slab ocean confirm the dominant role of ocean dynamical processes for this SST asymmetry. The net surface heat flux, in contrast, works to reduce the SST asymmetry through its shortwave radiation and latent heat flux components, with the former being related to the nonlinear relationship between SST and convection, and the latter being attributable to Newtonian damping and air-sea stability effects. The suppressing effect of shortwave radiation on SST asymmetry is further verified by partially coupled overriding experiments.« less

Asymmetric response of the equatorial Pacific SST to climate warming and cooling

NASA Astrophysics Data System (ADS)

Luo, Y.; Liu, F.; Lu, J.

2017-12-01

The response of the equatorial Pacific Ocean to heat fluxes of equal amplitude but opposite sign is investigated using the Community Earth System Model (CESM). Results show a strong asymmetry in SST changes. In the eastern equatorial Pacific (EEP), the warming responding to the positive forcing exceeds the cooling to the negative forcing; while in the western equatorial Pacific (WEP), it is the other way around and the cooling surpasses the warming. This leads to a zonal dipole asymmetric structure, with positive values in the east and negative values in the west. A surface heat budget analysis suggests that the SST asymmetry is mainly resulted from the oceanic horizontal advection and vertical entrainment, with both of their linear and nonlinear components playing a role. For the linear component, its change appears to be more significant over the EEP (WEP) in the positive (negative) forcing scenario, favoring the seesaw pattern of the SST asymmetry. For the nonlinear component, its change acts to warm (cool) the EEP (WEP) in both scenarios, also favorable for the development of the SST asymmetry. Additional experiments with a slab ocean confirm the dominant role of ocean dynamical processes for this SST asymmetry. The net surface heat flux, in contrast, works to reduce the SST asymmetry through its shortwave radiation and latent heat flux components, with the former being related to the nonlinear relationship between SST and convection, and the latter being attributable to Newtonian damping and air-sea stability effects. The suppressing effect of shortwave radiation on SST asymmetry is further verified by partially coupled overriding experiments.

21 CFR 180.30 - Brominated vegetable oil.

Code of Federal Regulations, 2010 CFR

2010-04-01

... million in the finished beverage, pending the outcome of additional toxicological studies on which... INTERIM BASIS PENDING ADDITIONAL STUDY Specific Requirements for Certain Food Additives § 180.30... used on an interim basis as a stabilizer for flavoring oils used in fruit-flavored beverages, for which...

Middle Pliocene sea surface temperature variability

USGS Publications Warehouse

Dowsett, H.J.; Chandler, M.A.; Cronin, T. M.; Dwyer, Gary S.

2005-01-01

Estimates of sea surface temperature (SST) based upon foraminifer, diatom, and ostracod assemblages from ocean cores reveal a warm phase of the Pliocene between about 3.3 and 3.0 Ma. Pollen records and plant megafossils, although not as well dated, show evidence for a warmer climate at about the same time. Increased greenhouse forcing and altered ocean heat transport are the leading candidates for the underlying cause of Pliocene global warmth. Despite being a period of global warmth, this interval encompasses considerable variability. Two new SST reconstructions are presented that are designed to provide a climatological error bar for warm peak phases of the Pliocene and to document the spatial distribution and magnitude of SST variability within the mid-Pliocene warm period. These data suggest long-term stability of low-latitude SST and document greater variability in regions of maximum warming. Copyright 2005 by the American Geophysical Union.

Assembly & Metrology of First Wall Components of SST-1

NASA Astrophysics Data System (ADS)

Parekh, Tejas; Santra, Prosenjit; Biswas, Prabal; Patel, Hiteshkumar; Paravastu, Yuvakiran; Jaiswal, Snehal; Chauhan, Pradeep; Babu, Gattu Ramesh; A, Arun Prakash; Bhavsar, Dhaval; Raval, Dilip C.; Khan, Ziauddin; Pradhan, Subrata

2017-04-01

First Wall Components (FWC) of SST-1 tokamak, which are in the immediate vicinity of plasma comprises of limiters, divertors, baffles, passive stabilizers are designed to operate long duration (1000 s) discharges of elongated plasma. All FWC consists of a copper alloy heat sink modules with SS cooling tubes brazed onto it, graphite tiles acting as armour material facing the plasma, and are mounted to the vacuum vessels with suitable Inconel support structures at ring & port locations. The FWC are very recently assembled and commissioned successfully inside the vacuum vessel of SST-1 undergoing a meticulous planning of assembly sequence, quality checks at every stage of the assembly process. This paper will present the metrology aspects & procedure of each FWC, both outside the vacuum vessel, and inside the vessel, assembly tolerances, tools, equipment and jig/fixtures, used at each stage of assembly, starting from location of support bases on vessel rings, fixing of copper modules on support structures, around 3800 graphite tile mounting on 136 copper modules with proper tightening torques, till final toroidal and poloidal geometry of the in-vessel components are obtained within acceptable limits, also ensuring electrical continuity of passive stabilizers to form a closed saddle loop, electrical isolation of passive stabilizers from vacuum vessel.

Genome-Scale Analysis Reveals Sst2 as the Principal Regulator of Mating Pheromone Signaling in the Yeast Saccharomyces cerevisiae†

PubMed Central

Chasse, Scott A.; Flanary, Paul; Parnell, Stephen C.; Hao, Nan; Cha, Jiyoung Y.; Siderovski, David P.; Dohlman, Henrik G.

2006-01-01

A common property of G protein-coupled receptors is that they become less responsive with prolonged stimulation. Regulators of G protein signaling (RGS proteins) are well known to accelerate G protein GTPase activity and do so by stabilizing the transition state conformation of the G protein α subunit. In the yeast Saccharomyces cerevisiae there are four RGS-homologous proteins (Sst2, Rgs2, Rax1, and Mdm1) and two Gα proteins (Gpa1 and Gpa2). We show that Sst2 is the only RGS protein that binds selectively to the transition state conformation of Gpa1. The other RGS proteins also bind Gpa1 and modulate pheromone signaling, but to a lesser extent and in a manner clearly distinct from Sst2. To identify other candidate pathway regulators, we compared pheromone responses in 4,349 gene deletion mutants representing nearly all nonessential genes in yeast. A number of mutants produced an increase (sst2, bar1, asc1, and ygl024w) or decrease (cla4) in pheromone sensitivity or resulted in pheromone-independent signaling (sst2, pbs2, gas1, and ygl024w). These findings suggest that Sst2 is the principal regulator of Gpa1-mediated signaling in vivo but that other proteins also contribute in distinct ways to pathway regulation. PMID:16467474

Improving Satellite Retrieved Infrared Sea Surface Temperatures in Aerosol-Contaminated Regions

NASA Astrophysics Data System (ADS)

Luo, B.; Minnett, P. J.; Szczodrak, G.; Kilpatrick, K. A.

2017-12-01

Infrared satellite observations of sea surface temperature (SST) have become essential for many applications in meteorology, climatology, and oceanography. Applications often require high accuracy SST data: for climate research and monitoring an absolute uncertainty of 0.1K and stability of better than 0.04K per decade are required. Tropospheric aerosol concentrations increase infrared signal attenuation and prevent the retrieval of accurate satellite SST. We compare satellite-derived skin SST with measurements from the Marine-Atmospheric Emitted Radiance Interferometer (M-AERI) deployed on ships during the Aerosols and Ocean Science Expeditions (AEROSE) and with quality-controlled drifter temperatures. After match-up with in-situ SST and filtering of cloud contaminated data, the results indicate that SST retrieved from MODIS (Moderate Resolution Imaging Spectroradiometer) aboard the Terra and Aqua satellites have negative (cool) biases compared to shipboard radiometric measurements. There is also a pronounced negative bias in the Saharan outflow area that can introduce SST errors >1 K at aerosol optical depths > 0.5. In this study, we present a new method to derive night-time Saharan Dust Index (SDI) algorithms based on simulated brightness temperatures at infrared wavelengths of 3.9, 10.8 and 12.0 μm, derived using RTTOV. We derived correction coefficients for Aqua MODIS measurements by regression of the SST errors against the SDI. The biases and standard deviations are reduced by 0.25K and 0.19K after the SDI correction. The goal of this study is to understand better the characteristics and physical mechanisms of aerosol effects on satellite retrieved infrared SST, as well as to derive empirical formulae for improved accuracies in aerosol-contaminated regions.

[111In-DOTA]LTT-SS28, a first pansomatostatin radioligand for in vivo targeting of somatostatin receptor-positive tumors.

PubMed

Maina, Theodosia; Cescato, Renzo; Waser, Beatrice; Tatsi, Aikaterini; Kaloudi, Aikaterini; Krenning, Eric P; de Jong, Marion; Nock, Berthold A; Reubi, Jean Claude

2014-08-14

Radiolabeled pansomatostatin-like analogues are expected to enhance the diagnostic sensitivity and to expand the clinical indications of currently applied sst2-specific radioligands. In this study, we present the somatostatin mimic [DOTA]LTT-SS28 {[(DOTA)Ser1,Leu8,D-Trp22,Tyr25]SS28} and its 111In radioligand. [DOTA]LTT-SS28 exhibited a pansomatostatin-like profile binding with high affinity to all five hsst1-hsst5 subtypes (IC50 values in the lower nanomolar range). Furthermore, [DOTA]LTT-SS28 behaved as an agonist at hsst2, hsst3, and hsst5, efficiently stimulating internalization of the three receptor subtypes. Radioligand [111In-DOTA]LTT-SS28 showed good stability in the mouse bloodstream. It displayed strong and specific uptake in AR42J tumors 4 h postinjection (9.3±1.6% ID/g vs 0.3±0.0% ID/g during sst2 blockade) in mice. Significant and specific uptake was also observed in HEK293-hsst2-, HEK293-hsst3-, and HEK293-hsst5-expressing tumors (4.43±1.5, 4.88±1.1, and <3% ID/g, respectively, with values of <0.5% ID/g during receptor blockade). In conclusion, the somatostatin mimic [111In-DOTA]LTT-SS28 specifically localizes in sst2-, sst3-, and sst5-expressing xenografts in mice showing promise for multi-sst1-sst5 targeted tumor imaging.

The impact of low-level cloud over the eastern subtropical Pacific on the ``Double ITCZ'' in LASG FGCM-0

NASA Astrophysics Data System (ADS)

Dai, Fushan; Yu, Rucong; Zhang, Xuehong; Yu, Yongqiang; Li, Jianglong

2003-05-01

Like many other coupled models, the Flexible coupled General Circulation Model (FGCM-0) suffers from the spurious “Double ITCZ”. In order to understand the “Double ITCZ” in FGCM-0, this study first examines the low-level cloud cover and the bulk stability of the low troposphere over the eastern subtropical Pacific simulated by the National Center for Atmospheric Research (NCAR) Community Climate Model version 3 (CCM3), which is the atmosphere component model of FGCM-0. It is found that the bulk stability of the low troposphere simulated by CCM3 is very consistent with the one derived from the National Center for Environmental Prediction (NCEP) reanalysis, but the simulated low-level cloud cover is much less than that derived from the International Satellite Cloud Climatology Project (ISCCP) D2 data. Based on the regression equations between the low-level cloud cover from the ISCCP data and the bulk stability of the low troposphere derived from the NCEP reanalysis, the parameterization scheme of low-level cloud in CCM3 is modified and used in sensitivity experiments to examine the impact of low-level cloud over the eastern subtropical Pacific on the spurious “Double ITCZ” in FGCM-0. Results show that the modified scheme causes the simulated low-level cloud cover to be improved locally over the cold oceans. Increasing the low-level cloud cover off Peru not only significantly alleviates the SST warm biases in the southeastern tropical Pacific, but also causes the equatorial cold tongue to be strengthened and to extend further west. Increasing the low-level cloud fraction off California effectively reduces the SST warm biases in ITCZ north of the equator. In order to examine the feedback between the SST and low-level cloud cover off Peru, one additional sensitivity experiment is performed in which the SST over the cold ocean off Peru is restored. It shows that decreasing the SST results in similar impacts over the wide regions from the southeastern tropical Pacific northwestwards to the western/central equatorial Pacific as increasing the low-level cloud cover does.

Rasch analysis indicates that the Simple Shoulder Test is robust, but minor item modifications and attention to gender differences should be considered.

PubMed

Raman, Jayaprakash; MacDermid, Joy C; Walton, David; Athwal, George S

Repeated cross-sectional study. Multiple studies have evaluated the psychometric properties of the Simple Shoulder Test (SST) through traditional methods supporting it as valid and reliable. Since the evidentiary pool supporting the use of the SST has only partially addressed key measurement properties and the development of SST pre-dates the common use of Rasch model, validation of SST has become a necessity to establish as a reliable and valid PRO for shoulder conditions. To date, no study has analysed SST through Rasch, a modern method for analyzing properties of measurement tools. The purpose of this study was to perform a Rasch analysis of the SST to assess the overall fit to the Rasch model, individual item fit, gender-based DIF, local dependency of items and the unidimensionality of the scale. A secondary purpose was to determine the stability of fit to the Rasch model when captured pre-operatively or post-operatively. Patients completed SST before surgery and between 6 months and 1 year after surgery. Rasch analysis was performed to analyse the carious properties of SST through the Rasch model. SST appears to be robust when tested against the Rasch model. Rasch analysis has highlighted potential areas for to improve in the SST questionnaire. The potential areas to improve are to consider questions that measure the ability of a person to lift the arm above shoulder level and to consider gender differences when measuring the ability to carry weights with the affected arm. This study adds to previous body of empirical evidence arising classical measurement approaches that have suggested that the SST has robust measurement properties, by providing evidence of adequate fit to the Rasch model after minor adjustments. The results of this study should provide confidence to clinicians on SST who wish to use a brief shoulder-specific measure in their practice. The SST appears to be robust when tested against the Rasch model despite some potential areas for improvement. The potential areas that should be explored in future Rasch analyses are the questions that measure the ability of a person to lift the arm above shoulder level and the potential for gender differences when measuring the ability to carry weights with the affected arm. Copyright © 2017 Hanley & Belfus. Published by Elsevier Inc. All rights reserved.

Effects of Northern Hemisphere Sea Surface Temperature Changes on the Global Air Quality

NASA Astrophysics Data System (ADS)

Yi, K.; Liu, J.

2017-12-01

The roles of regional sea surface temperature (SST) variability on modulating the climate system and consequently the air quality are investigated using the Community Earth System Model (CESM). Idealized, spatially uniform SST anomalies of +/- 1 °C are superimposed onto the North Pacific, North Atlantic, and North Indian Oceans individually. Ignoring the response of natural emissions, our simulations suggest large seasonal and regional variability of surface O3 and PM2.5 concentrations in response to SST anomalies, especially during boreal summers. Increasing the SST by 1 °C in one of the oceans generally decreases the surface O3 concentrations from 1 to 5 ppbv while increases the anthropogenic PM2.5 concentrations from 0.5 to 3 µg m-3. We implement the integrated process rate (IPR) analysis in CESM and find that meteorological transport in response to SST changes is the key process causing air pollutant perturbations in most cases. During boreal summers, the increase in tropical SST over different ocean basins enhances deep convection, which significantly increases the air temperature over the upper troposphere and trigger large-scale subsidence over nearby and remote regions. These processes tend to increase tropospheric stability and suppress rainfall at lower mid-latitudes. Consequently, it reduces the vertical transport of O3 to the surface while facilitating the accumulation of PM2.5 concentrations over most regions. In addition, this regional SST warming may also considerably suppress intercontinental transport of air pollution as confirmed with idealized CO-like tracers. Our findings indicate a robust linkage between basin-scale SST variability and regional air quality, which can help local air quality management.

Equilibrium Atmospheric Response to North Atlantic SST Anomalies.

NASA Astrophysics Data System (ADS)

Kushnir, Yochanan; Held, Isaac M.

1996-06-01

The equilibrium general circulation model (GCM) response to sea surface temperature (SST) anomalies in the western North Atlantic region is studied. A coarse resolution GCM, with realistic lower boundary conditions including topography and climatological SST distribution, is integrated in perpetual January and perpetual October modes, distinguished from one another by the strength of the midlatitude westerlies. An SST anomaly with a maximum of 4°C is added to the climatological SST distribution of the model with both positive and negative polarity. These anomaly runs are compared to one another, and to a control integration, to determine the atmospheric response. In all cases warming (cooling) of the midlatitude ocean surface yields a warming (cooling) of the atmosphere over and to the east of the SST anomaly center. The atmospheric temperature change is largest near the surface and decreases upward. Consistent with this simple thermal response, the geopotential height field displays a baroclinic response with a shallow anomalous low somewhat downstream from the warm SST anomaly. The equivalent barotropic, downstream response is weak and not robust. To help interpret the results, the realistic GCM integrations are compared with parallel idealized model runs. The idealized model has full physics and a similar horizontal and vertical resolution, but an all-ocean surface with a single, permanent zonal asymmetry. The idealized and realistic versions of the GCM display compatible response patterns that are qualitatively consistent with stationary, linear, quasigeostrophic theory. However, the idealized model response is stronger and more coherent. The differences between the two model response patterns can be reconciled based on the size of the anomaly, the model treatment of cloud-radiation interaction, and the static stability of the model atmosphere in the vicinity of the SST anomaly. Model results are contrasted with other GCM studies and observations.

Response of the global surface ozone distribution to Northern Hemisphere sea surface temperature changes: implications for long-range transport

NASA Astrophysics Data System (ADS)

Yi, Kan; Liu, Junfeng; Ban-Weiss, George; Zhang, Jiachen; Tao, Wei; Cheng, Yanli; Tao, Shu

2017-07-01

The response of surface ozone (O3) concentrations to basin-scale warming and cooling of Northern Hemisphere oceans is investigated using the Community Earth System Model (CESM). Idealized, spatially uniform sea surface temperature (SST) anomalies of ±1 °C are individually superimposed onto the North Pacific, North Atlantic, and North Indian oceans. Our simulations suggest large seasonal and regional variability in surface O3 in response to SST anomalies, especially in the boreal summer. The responses of surface O3 associated with basin-scale SST warming and cooling have similar magnitude but are opposite in sign. Increasing the SST by 1 °C in one of the oceans generally decreases the surface O3 concentrations from 1 to 5 ppbv. With fixed emissions, SST increases in a specific ocean basin in the Northern Hemisphere tend to increase the summertime surface O3 concentrations over upwind regions, accompanied by a widespread reduction over downwind continents. We implement the integrated process rate (IPR) analysis in CESM and find that meteorological O3 transport in response to SST changes is the key process causing surface O3 perturbations in most cases. During the boreal summer, basin-scale SST warming facilitates the vertical transport of O3 to the surface over upwind regions while significantly reducing the vertical transport over downwind continents. This process, as confirmed by tagged CO-like tracers, indicates a considerable suppression of intercontinental O3 transport due to increased tropospheric stability at lower midlatitudes induced by SST changes. Conversely, the responses of chemical O3 production to regional SST warming can exert positive effects on surface O3 levels over highly polluted continents, except South Asia, where intensified cloud loading in response to North Indian SST warming depresses both the surface air temperature and solar radiation, and thus photochemical O3 production. Our findings indicate a robust linkage between basin-scale SST variability and continental surface O3 pollution, which should be considered in regional air quality management.

Evidence of multidecadal climate variability and the Atlantic Multidecadal Oscillation from a Gulf of Mexico sea-surface temperature-proxy record

USGS Publications Warehouse

Poore, R.Z.; DeLong, K.L.; Richey, J.N.; Quinn, T.M.

2009-01-01

A comparison of a Mg/Ca-based sea-surface temperature (SST)-anomaly record from the northern Gulf of Mexico, a calculated index of variability in observed North Atlantic SST known as the Atlantic Multidecadal Oscillation (AMO), and a tree-ring reconstruction of the AMO contain similar patterns of variation over the last 110 years. Thus, the multidecadal variability observed in the instrumental record is present in the tree-ring and Mg/Ca proxy data. Frequency analysis of the Gulf of Mexico SST record and the tree-ring AMO reconstruction from 1550 to 1990 found similar multidecadal-scale periodicities (???30-60 years). This multidecadal periodicity is about half the observed (60-80 years) variability identified in the AMO for the 20th century. The historical records of hurricane landfalls reveal increased landfalls in the Gulf Coast region during time intervals when the AMO index is positive (warmer SST), and decreased landfalls when the AMO index is negative (cooler SST). Thus, we conclude that alternating intervals of high and low hurricane landfall occurrences may continue on multidecadal timescales along the northern Gulf Coast. However, given the short length of the instrumental record, the actual frequency and stability of the AMO are uncertain, and additional AMO proxy records are needed to establish the character of multidecadal-scale SST variability in the North Atlantic. ?? 2009 US Government.

Cool Down Experiences with the SST-1 Helium Cryogenics System before and after Current Feeders System Modification

NASA Astrophysics Data System (ADS)

Patel, R.; Panchal, P.; Panchal, R.; Tank, J.; Mahesuriya, G.; Sonara, D.; Srikanth, G. L. N.; Garg, A.; Bairagi, N.; Christian, D.; Patel, K.; Shah, P.; Nimavat, H.; Sharma, R.; Patel, J. C.; Gupta, N. C.; Prasad, U.; Sharma, A. N.; Tanna, V. L.; Pradhan, S.

The SST-1 machine comprises a superconducting magnet system (SCMS), which includes TF and PF magnets. In order to charge the SCMS, we need superconducting current feeders consisting of SC feeders and vapor cooled current leads (VCCLs). We have installed all 10 (+/-) pairs of VCCLs for the TF and PF systems. While conducting initial engineering validation of the SST-1 machine, our prime objective was to produce circular plasma using only the TF system. During the SST-1 campaign I to VI, we have to stop the PF magnets cooling in order to get the cryo- stable conditions for current charging of the TF magnets system. In that case, the cooling of the PF current leads is not essential. It has been also observed that after aborting the PF system cooling, there was a limited experimental window of TF operation. Therefore, in the recent SST-1 campaign-VII, we removed the PF current leads (9 pairs) and kept only single (+/-) pair of the 10,000 A rated VCCLs to realize the charging of the TF system for the extended window of operation. We have observed a better cryogenic stability in the TF magnets after modifications in the CFS. In this paper, we report the comparison of the cool down performance for the SST-1 machine operation before and after modifications of the current feeders system.

Color stability and marginal integrity of interim crowns: An in vitro study

PubMed Central

Elagra, Marwa I.; Rayyan, Mohammad R.; Alhomaidhi, Maisam M.; Alanaziy, Areej A.; Alnefaie, Mona O.

2017-01-01

Objective: Many commercial dental materials are used to fabricate interim restorations. This study aimed to compare the color stability and the marginal integrity of four different interim crown materials. Materials and Methods: An ivorine right maxillary central incisor was prepared for a full coverage all-ceramic restoration. A total of 36 specimens in the form of crowns were fabricated on the master die using four different materials (n = 9); Polymethyl methacrylate (PMMA) resin (TrimPLUS), PMMA computer-aided design, and computer-aided manufacturing (CAD-CAM) blocks (Ceramill TEMP), cold cure bis-acryl resin (Success CD), and bis-acryl resin dual-cure composite (TempSpan). Color change ΔE for each sample was calculated by measuring its color as Commission Internationale de l’Eclairage L* a* b* with a spectrophotometer before and after immersing in a concentrated tea solution for 7 days. Marginal gap was measured at four reference points using stereomicroscope at ×40. One-way ANOVA and the Tukey multiple comparisons test were used to determine any statistically significant difference between the four groups, (α = 0.05). Results: Success CD showed significantly the greatest color change (7.7) among all the tested materials, while no significant difference was found between the other three materials. TempSpan showed significantly the highest marginal gap formation (430.15 μm), while no significant difference was found between the three other materials. Conclusions: Bis-acryl resin composite materials demonstrated clinically noticeable change in color while PMMA materials demonstrated superior color stability. Dual cure interim materials exhibited significantly higher marginal discrepancy in comparison to PMMA and cold cure bis-acrylic resin materials. CAD-CAM PMMA material exhibited the best color stability and marginal integrity. PMID:28932142

Environmental Assessment: Waste Tank Safety Program, Hanford Site, Richland, Washington

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1994-02-01

The US Department of Energy (DOE) needs to take action in the near-term, to accelerate resolution of waste tank safety issues at the Hanford Site near the City of Richland, Washington, and reduce the risks associated with operations and management of the waste tanks. The DOE has conducted nuclear waste management operations at the Hanford Site for nearly 50 years. Operations have included storage of high-level nuclear waste in 177 underground storage tanks (UST), both in single-shell tank (SST) and double-shell tank configurations. Many of the tanks, and the equipment needed to operate them, are deteriorated. Sixty-seven SSTs are presumedmore » to have leaked a total approximately 3,800,000 liters (1 million gallons) of radioactive waste to the soil. Safety issues associated with the waste have been identified, and include (1) flammable gas generation and episodic release; (2) ferrocyanide-containing wastes; (3) a floating organic solvent layer in Tank 241-C-103; (4) nuclear criticality; (5) toxic vapors; (6) infrastructure upgrades; and (7) interim stabilization of SSTs. Initial actions have been taken in all of these areas; however, much work remains before a full understanding of the tank waste behavior is achieved. The DOE needs to accelerate the resolution of tank safety concerns to reduce the risk of an unanticipated radioactive or chemical release to the environment, while continuing to manage the wastes safely.« less

Soil stabilization field trial : interim report II.

DOT National Transportation Integrated Search

2002-02-01

Shrinkage cracks in cement-stabilized bases/subbase can be alleviated by specifying the right cement dosage, or by other additives/procedures that suppress crack susceptibility. A field trial of six 1000 ft sections to investigate several alternative...

Soil stabilization field trial : interim report.

DOT National Transportation Integrated Search

2001-04-01

Shrinkage cracks in cement-stabilized bases/subbase can be alleviated by specifying : the right cement dosage, or by other additives/procedures that suppress crack susceptibility. A field : trial of six 1000 ft test sections to investigate several al...

Soil stabilization field trial : interim report I.

DOT National Transportation Integrated Search

2001-04-01

Shrinkage cracks in cement-stabilized bases/subbase can be alleviated by specifying the right cement dosage, or by other additives/procedures that suppress crack susceptibility. A field trial of six 1000 ft test sections to investigate several altern...

Soil stabilization field trial : interim report III.

DOT National Transportation Integrated Search

2003-11-01

Shrinkage cracks in cement-stabilized bases/subbase can be alleviated by specifying the right cement dosage, or by other additives/procedures that suppress crack susceptibility. A field trial of six 1000 ft test sections to investigate several altern...

Analysis of variability of tropical Pacific sea surface temperatures

NASA Astrophysics Data System (ADS)

Davies, Georgina; Cressie, Noel

2016-11-01

Sea surface temperature (SST) in the Pacific Ocean is a key component of many global climate models and the El Niño-Southern Oscillation (ENSO) phenomenon. We shall analyse SST for the period November 1981-December 2014. To study the temporal variability of the ENSO phenomenon, we have selected a subregion of the tropical Pacific Ocean, namely the Niño 3.4 region, as it is thought to be the area where SST anomalies indicate most clearly ENSO's influence on the global atmosphere. SST anomalies, obtained by subtracting the appropriate monthly averages from the data, are the focus of the majority of previous analyses of the Pacific and other oceans' SSTs. Preliminary data analysis showed that not only Niño 3.4 spatial means but also Niño 3.4 spatial variances varied with month of the year. In this article, we conduct an analysis of the raw SST data and introduce diagnostic plots (here, plots of variability vs. central tendency). These plots show strong negative dependence between the spatial standard deviation and the spatial mean. Outliers are present, so we consider robust regression to obtain intercept and slope estimates for the 12 individual months and for all-months-combined. Based on this mean-standard deviation relationship, we define a variance-stabilizing transformation. On the transformed scale, we describe the Niño 3.4 SST time series with a statistical model that is linear, heteroskedastic, and dynamical.

The Onset of the Madden-Julian Oscillation Within an Aquaplanet Model

NASA Technical Reports Server (NTRS)

Colon, Edward; Lindesay, James; Suarez, Max

1997-01-01

A series of numerical experiments using a two-level atmospheric general circulation model (AGCM) were performed for the purpose of investigating the coupling between sea surface temperature (SST) profile and the onset of the Madden-Julian Oscillation (MJO). The AGCM was modified to run as an aquaplane with all seasonal forcing removed. SST distributions based on the New Global Sea-Ice and Sea Surface Temperature (GISST) Data Set for 1903-1994 were generated then modified to vary the north-south gradient and tropical temperatures. It was found that the MJO signal did not depend on the SST temperature gradients but rather on the absolute temperature of the equatorial region, EOF analysis revealed that the SST distribution which generated the strongest MJO signal produced a periodic fluctuation in velocity potential at the 250 millibar level with a phase speed of 15 m/s, and a periodicity of 30 days which falls within the shortest limit of observed oscillations. This distribution also possessed the coolest equatorial SSTs which suggests that increased stability in the atmosphere favors the occurrence of organized MJO propagation.

Forced synchronization of large-scale circulation to increase predictability of surface states

NASA Astrophysics Data System (ADS)

Shen, Mao-Lin; Keenlyside, Noel; Selten, Frank; Wiegerinck, Wim; Duane, Gregory

2016-04-01

Numerical models are key tools in the projection of the future climate change. The lack of perfect initial condition and perfect knowledge of the laws of physics, as well as inherent chaotic behavior limit predictions. Conceptually, the atmospheric variables can be decomposed into a predictable component (signal) and an unpredictable component (noise). In ensemble prediction the anomaly of ensemble mean is regarded as the signal and the ensemble spread the noise. Naturally the prediction skill will be higher if the signal-to-noise ratio (SNR) is larger in the initial conditions. We run two ensemble experiments in order to explore a way to reduce the SNR of surface winds and temperature. One ensemble experiment is AGCM with prescribing sea surface temperature (SST); the other is AGCM with both prescribing SST and nudging the high-level temperature and winds to ERA-Interim. Each ensemble has 30 members. Larger SNR is expected and found over the tropical ocean in the first experiment because the tropical circulation is associated with the convection and the associated surface wind convergence as these are to a large extent driven by the SST. However, small SNR is found over high latitude ocean and land surface due to the chaotic and non-synchronized atmosphere states. In the second experiment the higher level temperature and winds are forced to be synchronized (nudged to reanalysis) and hence a larger SNR of surface winds and temperature is expected. Furthermore, different nudging coefficients are also tested in order to understand the limitation of both synchronization of large-scale circulation and the surface states. These experiments will be useful for the developing strategies to synchronize the 3-D states of atmospheric models that can be later used to build a super model.

Using foamed asphalt as a stabilizing agent in full depth reclamation of Route 8 in Belgrade : interim report - first year, December 2003.

DOT National Transportation Integrated Search

2003-12-01

Maine has a variety of soil types throughout the state. Most of these soil types degrade rapidly and have : poor stability. To eliminate the cost of supplying quality road base material from a distant source and : increase the stability of existing s...

Using foamed asphalt as a stabilizing agent in full depth reclamation of Route 8 in Belgrade : interim report - third and fourth year, October 2006.

DOT National Transportation Integrated Search

2006-10-01

Maine has a variety of soil types throughout the state. A majority of these soil types degrade rapidly and : have poor stability. To eliminate the cost of supplying quality road base material from a distant source and : increase the stability of exis...

Interactions Between the Thermohaline Circulation and Tropical Atlantic SST in a Coupled General Circulation Model

NASA Technical Reports Server (NTRS)

Miller, Ron; Jiang, Xing-Jian; Travis, Larry (Technical Monitor)

2001-01-01

Tropical Atlantic SST shows a (statistically well-defined) decadal time scale in a 104-year simulation of unforced variability by a coupled general circulation model (CGCM). The SST anomalies superficially resemble observed Tropical Atlantic variability (TAV), and are associated with changes in the atmospheric circulation. Brazilian rainfall is modulated with a decadal time scale, along with the strength of the Atlantic trade winds, which are associated with variations in evaporation and the net surface heat flux. However, in contrast to observed tropical Atlantic variability, the trade winds damp the associated anomalies in ocean temperature, indicating a negative feedback. Tropical SST anomalies in the CGCM, though opposed by the surface heat flux, are advected in from the Southern Hemisphere mid-latitudes. These variations modulate the strength of the thermohaline circulation (THC): warm, salty anomalies at the equator sink drawing cold, fresh mid-latitude water. Upon reaching the equator, the latter inhibit vertical overturning and advection from higher latitudes, which allows warm, salty anomalies to reform, returning the cycle to its original state. Thus, the cycle results from advection of density anomalies and the effect of these anomalies upon the rate of vertical overturning and surface advection. This decadal modulation of Tropical Atlantic SST and the thermohaline circulation is correlated with ocean heat transport to the Northern Hemisphere high latitudes and Norwegian Sea SST. Because of the central role of equatorial convection, we question whether this mechanism is present in the current climate, although we speculate that it may have operated in palaeo times, depending upon the stability of the tropical water column.

Mixed layer modeling in the East Pacific warm pool during 2002

NASA Astrophysics Data System (ADS)

Van Roekel, Luke P.; Maloney, Eric D.

2012-06-01

Two vertical mixing models (the modified dynamic instability model of Price et al.; PWP, and K-Profile Parameterizaton; KPP) are used to analyze intraseasonal sea surface temperature (SST) variability in the northeast tropical Pacific near the Costa Rica Dome during boreal summer of 2002. Anomalies in surface latent heat flux and shortwave radiation are the root cause of the three intraseasonal SST oscillations of order 1°C amplitude that occur during this time, although surface stress variations have a significant impact on the third event. A slab ocean model that uses observed monthly varying mixed layer depths and accounts for penetrating shortwave radiation appears to well-simulate the first two SST oscillations, but not the third. The third oscillation is associated with small mixed layer depths (<5 m) forced by, and acting with, weak surface stresses and a stabilizing heat flux that cause a transient spike in SST of 2°C. Intraseasonal variations in freshwater flux due to precipitation and diurnal flux variability do not significantly impact these intraseasonal oscillations. These results suggest that a slab ocean coupled to an atmospheric general circulation model, as used in previous studies of east Pacific intraseasonal variability, may not be entirely adequate to realistically simulate SST variations. Further, while most of the results from the PWP and KPP models are similar, some important differences that emerge are discussed.

Ocean-Atmosphere Interaction Over Agulhas Extension Meanders

NASA Technical Reports Server (NTRS)

Liu, W. Timothy; Xie, Xiaosu; Niiler, Pearn P.

2007-01-01

Many years of high-resolution measurements by a number of space-based sensors and from Lagrangian drifters became available recently and are used to examine the persistent atmospheric imprints of the semi-permanent meanders of the Agulhas Extension Current (AEC), where strong surface current and temperature gradients are found. The sea surface temperature (SST) measured by the Advanced Microwave Scanning Radiometer-Earth Observing System (AMSR-E) and the chlorophyll concentration measured by the Sea-viewing Wide Field-of-view Sensor (SeaWiFS) support the identification of the meanders and related ocean circulation by the drifters. The collocation of high and low magnitudes of equivalent neutral wind (ENW) measured by Quick Scatterometer (QuikSCAT), which is uniquely related to surface stress by definition, illustrates not only the stability dependence of turbulent mixing but also the unique stress measuring capability of the scatterometer. The observed rotation of ENW in opposition to the rotation of the surface current clearly demonstrates that the scatterometer measures stress rather than winds. The clear differences between the distributions of wind and stress and the possible inadequacy of turbulent parameterization affirm the need of surface stress vector measurements, which were not available before the scatterometers. The opposite sign of the stress vorticity to current vorticity implies that the atmosphere spins down the current rotation through momentum transport. Coincident high SST and ENW over the southern extension of the meander enhance evaporation and latent heat flux, which cools the ocean. The atmosphere is found to provide negative feedback to ocean current and temperature gradients. Distribution of ENW convergence implies ascending motion on the downwind side of local SST maxima and descending air on the upwind side and acceleration of surface wind stress over warm water (deceleration over cool water); the convection may escalate the contrast of ENW over warm and cool water set up by the dependence of turbulent mixing on stability; this relation exerts a positive feedback to the ENW-SST relation. The temperature sounding measured by the Atmospheric Infrared Sounder(AIRS) is consistent with the spatial coherence between the cloud-top temperature provided by the International Satellite Cloud Climatology Project (ISCCP) and SST. Thus ocean mesoscale SST anomalies associated with the persistent meanders may have a long-term effect well above the midlatitude atmospheric boundary layer, an observation not addressed in the past.

Seasonal heterogeneity of ocean warming: a mortality sink for ectotherm colonizers.

PubMed

Maffucci, Fulvio; Corrado, Raffaele; Palatella, Luigi; Borra, Marco; Marullo, Salvatore; Hochscheid, Sandra; Lacorata, Guglielmo; Iudicone, Daniele

2016-04-05

Distribution shifts are a common adaptive response of marine ectotherms to climate change but the pace of redistribution depends on species-specific traits that may promote or hamper expansion to northern habitats. Here we show that recently, the loggerhead turtle (Caretta caretta) has begun to nest steadily beyond the northern edge of the species' range in the Mediterranean basin. This range expansion is associated with a significant warming of spring and summer sea surface temperature (SST) that offers a wider thermal window suitable for nesting. However, we found that post-hatchlings departing from this location experience low winter SST that may affect their survival and thus hamper the stabilization of the site by self-recruitment. The inspection of the Intergovernmental Panel on Climate Change model projections and observational data on SST trends shows that, despite the annual warming for this century, winter SST show little or no trends. Therefore, thermal constraints during the early developmental phase may limit the chance of population growth at this location also in the near future, despite increasingly favourable conditions at the nesting sites. Quantifying and understanding the interplay between dispersal and environmental changes at all life stages is critical for predicting ectotherm range expansion with climate warming.

Seasonal heterogeneity of ocean warming: a mortality sink for ectotherm colonizers

NASA Astrophysics Data System (ADS)

Maffucci, Fulvio; Corrado, Raffaele; Palatella, Luigi; Borra, Marco; Marullo, Salvatore; Hochscheid, Sandra; Lacorata, Guglielmo; Iudicone, Daniele

2016-04-01

Distribution shifts are a common adaptive response of marine ectotherms to climate change but the pace of redistribution depends on species-specific traits that may promote or hamper expansion to northern habitats. Here we show that recently, the loggerhead turtle (Caretta caretta) has begun to nest steadily beyond the northern edge of the species’ range in the Mediterranean basin. This range expansion is associated with a significant warming of spring and summer sea surface temperature (SST) that offers a wider thermal window suitable for nesting. However, we found that post-hatchlings departing from this location experience low winter SST that may affect their survival and thus hamper the stabilization of the site by self-recruitment. The inspection of the Intergovernmental Panel on Climate Change model projections and observational data on SST trends shows that, despite the annual warming for this century, winter SST show little or no trends. Therefore, thermal constraints during the early developmental phase may limit the chance of population growth at this location also in the near future, despite increasingly favourable conditions at the nesting sites. Quantifying and understanding the interplay between dispersal and environmental changes at all life stages is critical for predicting ectotherm range expansion with climate warming.

Stability of Beriplast P fibrin sealant: storage and reconstitution.

PubMed

Eberhard, Ulrich; Broder, Martin; Witzke, Günther

2006-04-26

This study was performed to investigate the stability of Beriplast P fibrin sealant (FS) across a range of storage conditions, both pre- and post-reconstitution. Storage stability of the FS was evaluated during long-term refrigeration (24 months) with or without interim storage at elevated temperatures (40 degrees C for 1 week and 25 degrees C for 1 and 3 months). Stability of individual FS components was assessed by measuring: fibrinogen content, Factor XIII activity (FXIII), thrombin activity and aprotinin potency. The package integrity of each component was also checked (sterility testing, moisture content and pH). Storage stability was also evaluated by testing the reconstituted product for adhesion (tearing force testing after mixing the solutions) and sterility. Reconstitution stability was evaluated following 3-months' storage, for up to 50 h post-reconstitution using the same tests as for the storage stability investigations. Pre-defined specifications were met for fibrinogen content, Factor XIII activity, and thrombin activity, demonstrating storage stability. Package integrity and the functionality and sterility of the reconstituted product were confirmed throughout. Reconstitution stability was demonstrated for up to 50 h following reconstitution, in terms of both tearing force and sterility tests. In conclusion, the storage stability of Beriplast P was demonstrated over a range of 24-month storage schedules including interim exposure to elevated temperature, and the reconstituted product was stable for up to 50 h.

The Challenge of Declining Enrolments. Critical Emerging Problems and Recommendations for Immediate Action. Interim Report No. 2. [La Baisse des Effectifs Scolaires. Problemes Critiques et Recommandations pour une Action Immediate. Rapport Preliminaire No. 2].

ERIC Educational Resources Information Center

Jackson, Robert W. B.

This second interim report on declining enrollment in Ontario identifies the major implications of the several factors associated with declining enrollments and makes recommendations for immediate action to contribute to the stability of the system while preparing and initiating long-term policies. The first part of the report deals with…

Grabber arm mechanism for the Italian Research Interim Stage (IRIS)

NASA Technical Reports Server (NTRS)

Turci, Edmondo

1987-01-01

Two deployable arms, named grabbers, were designed and manufactured to provide lateral stability of the perigee spinning stage which will be deployed from the Space Shuttle cargo bay. The spinning stage is supported by a spin table on a cradle at its base. The Italian Research Interim Stage (IRIS) is designed to carry satellites of intermediate mass up to 900 kg. The requirements are defined and the mechanism is described. Functional test results are presented.

Intense air-sea exchanges and heavy orographic precipitation over Italy: The role of Adriatic sea surface temperature uncertainty

NASA Astrophysics Data System (ADS)

Stocchi, Paolo; Davolio, Silvio

2017-11-01

Strong and persistent low-level winds blowing over the Adriatic basin are often associated with intense precipitation events over Italy. Typically, in case of moist southeasterly wind (Sirocco), rainfall affects northeastern Italy and the Alpine chain, while with cold northeasterly currents (Bora) precipitations are localized along the eastern slopes of the Apennines and central Italy coastal areas. These events are favoured by intense air-sea interactions and it is reasonable to hypothesize that the Adriatic sea surface temperature (SST) can affect the amount and location of precipitation. High-resolution simulations of different Bora and Sirocco events leading to severe precipitation are performed using a convection-permitting model (MOLOCH). Sensitivity experiments varying the SST initialization field are performed with the aim of evaluating the impact of SST uncertainty on precipitation forecasts, which is a relevant topic for operational weather predictions, especially at local scales. Moreover, diagnostic tools to compute water vapour fluxes across the Italian coast and atmospheric water budget over the Adriatic Sea have been developed and applied in order to characterize the air mass that feeds the precipitating systems. Finally, the investigation of the processes through which the SST influences location and intensity of heavy precipitation allows to gain a better understanding on mechanisms conducive to severe weather in the Mediterranean area and in the Adriatic basin in particular. Results show that the effect of the Adriatic SST (uncertainty) on precipitation is complex and can vary considerably among different events. For both Bora and Sirocco events, SST does not influence markedly the atmospheric water budget or the degree of moistening of air that flows over the Adriatic Sea. SST mainly affects the stability of the atmospheric boundary layer, thus influencing the flow dynamics and the orographic flow regime, and in turn, the precipitation pattern.

Climate Trend Detection using Sea-Surface Temperature Data-sets from the (A)ATSR and AVHRR Space Sensors.

NASA Astrophysics Data System (ADS)

Llewellyn-Jones, D. T.; Corlett, G. K.; Remedios, J. J.; Noyes, E. J.; Good, S. A.

2007-05-01

Sea-Surface Temperature (SST) is an important indicator of global change, designated by GCOS as an essential Climate Variable (ECV). The detection of trends in Global SST requires rigorous measurements that are not only global, but also highly accurate and consistent. Space instruments can provide the means to achieve these required attributes in SST data. This paper presents an analysis of 15 years of SST data from two independent data sets, generated from the (A)ATSR and AVHRR series of sensors respectively. The analyses reveal trends of increasing global temperature between 0.13°C to 0.18 °C, per decade, closely matching that expected from some current predictions. A high level of consistency in the results from the two independent observing systems is seen, which gives increased confidence in data from both systems and also enables comparative analyses of the accuracy and stability of both data sets to be carried out. The conclusion is that these satellite SST data-sets provide important means to quantify and explore the processes of climate change. An analysis based upon singular value decomposition, allowing the removal of gross transitory disturbances, notably the El Niño, in order to examine regional areas of change other than the tropical Pacific, is also presented. Interestingly, although El Niño events clearly affect SST globally, they are found to have a non- significant (within error) effect on the calculated trends, which changed by only 0.01 K/decade when the pattern of El Niño and the associated variations was removed from the SST record. Although similar global trends were calculated for these two independent data sets, larger regional differences are noted. Evidence of decreased temperatures after the eruption of Mount Pinatubo in 1991 was also observed. The methodology demonstrated here can be applied to other data-sets, which cover long time-series observations of geophysical observations in order to characterise long-term change.

Effect of treatment with depot somatostatin analogue octreotide on primary hyperparathyroidism (PHP) in multiple endocrine neoplasia type 1 (MEN1) patients.

PubMed

Faggiano, Antongiulio; Tavares, Lidice Brandao; Tauchmanova, Libuse; Milone, Francesco; Mansueto, Gelsomina; Ramundo, Valeria; De Caro, Maria Laura Del Basso; Lombardi, Gaetano; De Rosa, Gaetano; Colao, Annamaria

2008-11-01

In patients with multiple endocrine neoplasia type 1 (MEN1), expression of somatostatin receptor (SST) in parathyroid adenomas and effectiveness of therapy with somatostatin analogues on primary hyperparathyroidism (PHP) have been scarcely investigated. To evaluate the effects of depot long acting octreotide (OCT-LAR) in patients with MEN1-related PHP. Eight patients with a genetically confirmed MEN1, presenting both PHP and duodeno-pancreatic neuroendocrine tumours (NET), were enrolled. The initial treatment was OCT-LAR 30 mg every 4 weeks. This therapy was established to stabilize the duodeno-pancreatic NET before to perform parathyroidectomy for PHP. Before OCT-LAR therapy, a SST scintigraphy was performed in all patients. SST subtype 2A immunohistochemistry was performed on parathyroid tumour samples from three patients undergone parathyroidectomy after OCT-LAR therapy. Serum concentrations of PTH, calcium and phosphorus as well as the 24-h urine calcium : creatinine ratio and the renal threshold phosphate concentration were evaluated before and after OCT-LAR. After OCT-LAR therapy, hypercalcaemia and hypercalciuria normalized in 75% and 62.5% of patients, respectively, and serum phosphorus and renal threshold phosphate significantly increased. Serum PTH concentrations significantly decreased in all patients and normalized in two of them. SST subtype 2A immunostaining was found in all parathyroid adenomas investigated, while SST scintigraphy showed a positive parathyroid tumour uptake in three of eight patients (37.5%). Six months of OCT-LAR therapy controlled hypercalcaemia and hypercalciuria in two-thirds of patients with MEN1-related PHP. Direct OCT-LAR effects mediated by binding to SST expression on parathyroid tumour cells are likely the main mechanism to explain the activity of this compound on calcium and phosphorus abnormalities in MEN1 PHP.

On the presence of coastal upwelling along the northeastern Tyrrhenian coast

NASA Astrophysics Data System (ADS)

Martellucci, Riccardo; Melchiorri, Cristiano; Costanzo, Lorenzo; Marcelli, Marco

2017-04-01

The Mediterranean region shows a high climate variability due to the interactions between mid-latitude and tropical processes. This variability makes the Mediterranean a potentially vulnerable region to climatic changes. The present research aims to investigate the hydrographical response to Northerly wind in the northeastern Tyrrhenian coast, to identify the relations between upwelling events and teleconnection patterns. In the Tyrrhenian basin northerly winds flow between North-East and North-West and could be considered upwelling favorable winds. This atmospheric circulation can causes a divergent flow near the coast that generates a subsurface water flows inshore toward the coast up to the surface layer that is upwelling. This phenomenon strongly influence the marine ecosystems, contributing to the supply of nutrients and affecting the primary producers. In this context multi-platform observing system is an important tool to follow the evolution of these phenomena. Sea temperature and wind field acquired by the C-CEMS Observing system were used to identify upwelling phenomena between 2012 and 2016, in the coastal area of Civitavecchia, Northern Tyrrhenian sea, Italy. Moreover a thirty years' wind-driven upwelling conditions have been studied in the area. ERA-Interim (ECMWF) wind data for the period 1982-2012 have been used to compute the distribution of upwelling favorable wind events. These have been compared to "Copernicus Marine Environment Monitoring Service" Sea Surface Temperature (SST) to compute upwelling events. Upwelling favorable wind has been defined in the sector between Northwest and Northeast (Wd >330°N & Wd < 30°N). Wind speed has been divided into three classes: between 4 m/s and 6 m/s, between 6 m/s and 8 m/s and greater than 8 m/s. Sea Surface Temperature have been analyzed to define SST field for wind-driven coastal upwelling assessment. SST minima along the coast was used to identify upwelling from satellite imagery. The two datasets were compared and only the days that presented those characteristics were chosen. ERA-Interim (ECMWF) sea level pressure data over the Europe for the period 1982 -2012 have been used to compute the most relevant teleconnection patterns through Empirical Orthogonal Function's analysis. An increase of upwelling events in the Tyrrhenian coast is observed in the last thirty years; the occurrence of upwelling events has a seasonal oscillation, with a maximum frequency during winter and spring seasons. In the last decade an increase of these events in winter and a decrease in spring is observed; also a recurrence of these events in summer season has been identified, without the specific contribution of one of atmospheric regimes. Data analyzed shows a decrement in Atlantic Ridge (AR) regime and an increment in West Blocking (WBL) regime, especially for the event characterized by wind speeds greater than 8m/s.

AVHRR, MODIS, and VIIRS radiometric stability and consistency in SST bands

NASA Astrophysics Data System (ADS)

Liang, XingMing; Ignatov, Alexander

2013-06-01

Monitoring of IR Clear-Sky Radiances over Oceans for SST (MICROS; www.star.nesdis.noaa.gov/sod/sst/micros) is NESDIS near-real time web-based radiance monitoring system. It analyzes Model (Community Radiative Transfer Model, CRTM) minus Observation (M-O) biases in brightness temperatures (BT) in three bands centered at 3.7 (IR37), 11 (IR11), and 12 µm (IR12), for several AVHRR (NOAA-16, -17, -18, -19, Metop-A, -B), VIIRS (Suomi National Polar Partnership, S-NPP), and MODIS (Terra, Aqua) sensors. Double-differences (DD) are employed to check BTs for radiometric stability and consistency. All sensors are stable, with the exception of two AVHRRs, onboard NOAA-16 and to a lesser extent NOAA-18, and generally consistent. VIIRS onboard S-NPP, launched in October 2011, is well in-family, especially after its calibration was fine-tuned on 7 March 2012. MODIS M-O biases were initially out-of-family by up to -0.6 K, due to incorrect CRTM transmittance coefficients. Following MICROS feedback, CRTM Team updated coefficients and brought MODIS back in-family. Terra and Aqua BTs are very consistent in IR11 and IR12 but show cross-platform bias of 0.3 K in IR37, likely attributed to MODIS characterization. Work with MODIS Characterization Support Team is underway to resolve this. Initial analyses of AVHRR onboard Metop-B launched in September 2012 suggest that its BTs are offset from Metop-A by up to ˜0.3 K. Overall, MICROS DDs are well suited to evaluate the sensors stability, but dedicated effort is needed to ensure consistent radiative transfer modeling (RTM) calculations for various sensors before DDs can be used in Global Space-based Inter-Calibration System (GSICS) quantitative applications.

Evaluation of the BD Vacutainer(®) RST blood collection tube for routine chemistry analytes: clinical significance of differences and stability study.

PubMed

Kocijancic, Marija; Cargonja, Jelena; Delic-Knezevic, Alma

2014-01-01

Preanalytical variables account for most of laboratory errors. There is a wide range of factors that affect the reliability of laboratory report. Most convenient sample type for routine laboratory analysis is serum. BD Vacutainer(®) Rapid Serum Tube (RST) (Becton, Dickinson and Company, Franklin Lakes, NJ, USA) blood collection tube provides rapid clotting time allowing fast serum separation. Our aim was to evaluate the comparability of routine chemistry parameters in BD Vacutainer(®) RST blood collection tube in reference with the BD Vacutainer(®) Serum Separating Tubes II Advance Tube (SST) (Becton, Dickinson and Company, Franklin Lakes, NJ, USA). Blood specimens were collected from 90 participants for evaluation on its results, clotting time and stability study of six routine biochemistry parameters: glucose (Glu), aspartate aminotransferase (AST), alanine aminotransferase (ALT), calcium (Ca), lactate dehidrogenase (LD) and potassium (K) measured with Olympus AU2700 analyzer (Beckman Coulter, Tokyo, Japan). The significance of the differences between samples was assessed by paired t-test or Wilcoxon Matched-Pairs Rank test after checking for normality. Clotting process was significantly shorter in the RSTs compared to SSTs (2.49 min vs. 19.47 min, respectively; P < 0.001). There was a statistically significant difference between the RST and SST II tubes for glucose, calcium and LD (P < 0.001). Differences for glucose and LD were also clinically significant. Analyte stability studies showed that all analytes were stable for 24 h at 4 °C. Most results (except LD and glucose) from RST are comparable with those from SST. In addition, RST tube provides shorter clotting time.

Modulations of aerosol impacts on cloud microphysics induced by the warm Kuroshio Current under the East Asian winter monsoon

NASA Astrophysics Data System (ADS)

Koike, M.; Asano, N.; Nakamura, H.; Sakai, S.; Nagao, T. M.; Nakajima, T. Y.

2016-10-01

In our previous aircraft observations, the possible influence of high sea surface temperature (SST) along the Kuroshio Current on aerosol-cloud interactions over the western North Pacific was revealed. The cloud droplet number concentration (Nc) was found to increase with decreasing near-surface static stability (NSS), which was evaluated locally as the difference between the SST and surface air temperature (SAT). To explore the spatial and temporal extent to which this warm SST influence can be operative, the present study analyzed Nc values estimated from Moderate Resolution Imaging Spectroradiometer (MODIS) satellite measurements. The comparison of the local Nc values between the high and low SST - SAT days revealed a marked increase in Nc (up to a factor of 1.8) along the Kuroshio Current in the southern East China Sea, where particularly high SST - SAT values (up to 8 K) were observed in winter under monsoonal cold air outflows from the Asian Continent. This cold airflow destabilizes the atmospheric boundary layer, which leads to enhanced updraft velocities within the well-developed mixed layer and thus greater Nc. The monsoonal northwesterlies also bring a large amount of anthropogenic aerosols from the Asian continent that increase Nc in the first place. These results suggest that the same modulations of cloud microphysics can occur over other warm western boundary currents, including the Gulf Stream, under polluted cool continental airflows. Possibilities of influencing the cloud liquid water path are also discussed.

Seasonal heterogeneity of ocean warming: a mortality sink for ectotherm colonizers

PubMed Central

Maffucci, Fulvio; Corrado, Raffaele; Palatella, Luigi; Borra, Marco; Marullo, Salvatore; Hochscheid, Sandra; Lacorata, Guglielmo; Iudicone, Daniele

2016-01-01

Distribution shifts are a common adaptive response of marine ectotherms to climate change but the pace of redistribution depends on species-specific traits that may promote or hamper expansion to northern habitats. Here we show that recently, the loggerhead turtle (Caretta caretta) has begun to nest steadily beyond the northern edge of the species’ range in the Mediterranean basin. This range expansion is associated with a significant warming of spring and summer sea surface temperature (SST) that offers a wider thermal window suitable for nesting. However, we found that post-hatchlings departing from this location experience low winter SST that may affect their survival and thus hamper the stabilization of the site by self-recruitment. The inspection of the Intergovernmental Panel on Climate Change model projections and observational data on SST trends shows that, despite the annual warming for this century, winter SST show little or no trends. Therefore, thermal constraints during the early developmental phase may limit the chance of population growth at this location also in the near future, despite increasingly favourable conditions at the nesting sites. Quantifying and understanding the interplay between dispersal and environmental changes at all life stages is critical for predicting ectotherm range expansion with climate warming. PMID:27044321

The role and meaning of interim housing in housing first programs for people experiencing homelessness and mental illness.

PubMed

Zerger, Suzanne; Francombe Pridham, Katherine; Jeyaratnam, Jeyagobi; Connelly, Jolynn; Hwang, Stephen; O'Campo, Patricia; Stergiopoulos, Vicky

2014-07-01

The housing first (HF) model for individuals experiencing homelessness and mental illness differs by design from traditional models that require consumers to achieve "housing readiness" by meeting program or treatment prerequisites in transitional housing settings prior to permanent housing placement. Given a growing body of evidence for its favorable outcomes and cost effectiveness, HF is increasingly seen as an alternative to and argument against these traditional programs. As such, it is important that the elements and implementation challenges of the HF model be clearly understood and articulated. This qualitative study explored a largely unexamined aspect of the HF model-the need for and meaning of temporary residential settings (interim housing), a place to stay while waiting to secure permanent housing-using interviews and focus groups with service providers and consumers who experienced interim housing during implementation of HF in a large urban center. Although interim housing may not be necessary for all programs implementing the model, our study revealed numerous reasons and demands for safe, flexible interim housing options, and illustrated how they influence the effectiveness of consumer recovery, continuous service engagement, and housing stability.

Moisture balance over the Iberian Peninsula computed using a high resolution regional climate model. The impact of 3DVAR data assimilation.

NASA Astrophysics Data System (ADS)

González-Rojí, Santos J.; Sáenz, Jon; Ibarra-Berastegi, Gabriel

2016-04-01

A numerical downscaling exercise over the Iberian Peninsula has been run nesting the WRF model inside ERA Interim. The Iberian Peninsula has been covered by a 15km x 15 km grid with 51 vertical levels. Two model configurations have been tested in two experiments spanning the period 2010-2014 after a one year spin-up (2009). In both cases, the model uses high resolution daily-varying SST fields and the Noah land surface model. In the first experiment (N), after the model is initialised, boundary conditions drive the model, as usual in numerical downscaling experiments. The second experiment (D) is configured the same way as the N case, but 3DVAR data assimilation is run every six hours (00Z, 06Z, 12Z and 18Z) using observations obtained from the PREPBUFR dataset (NCEP ADP Global Upper Air and Surface Weather Observations) using a 120' window around analysis times. For the data assimilation experiment (D), seasonally (monthly) varying background error covariance matrices have been prepared according to the parameterisations used and the mesoscale model domain. For both N and D runs, the moisture balance of the model runs has been evaluated over the Iberian Peninsula, both internally according to the model results (moisture balance in the model) and also in terms of the observed moisture fields from observational datasets (particularly precipitable water and precipitation from observations). Verification has been performed both at the daily and monthly time scales. The verification has also been performed for ERA Interim, the driving coarse-scale dataset used to drive the regional model too. Results show that the leading terms that must be considered over the area are the tendency in the precipitable water column, the divergence of moisture flux, evaporation (computed from latent heat flux at the surface) and precipitation. In the case of ERA Interim, the divergence of Qc is also relevant, although still a minor player in the moisture balance. Both mesoscale model runs are more effective at closing the moisture balance over the whole Iberian Peninsula than ERA Interim. The N experiment (no data assimilation) shows a better closure than the D case, as could be expected from the lack of analysis increments in it. This result is robust both at the daily and monthly time scales. Both ERA Interim and the D experiment produce a negative residual in the balance equation (compatible with excess evaporation or increased convergence of moisture over the Iberian Peninsula). This is a result of the data assimilation process in the D dataset, since in the N experiment the residual is mainly positive. The seasonal cycle of evaporation is much closer in the D experiment to the one in ERA Interim than in the N case, with a higher evaporation during summer months. However, both regional climate model runs show a lower evaporation rate than ERA Interim, particularly during summer months.

Influence of ocean surface conditions on atmospheric vertical thermodynamic structure and deep convection

NASA Technical Reports Server (NTRS)

Fu, Rong; Del Genio, Anthony D.; Rossow, William B.

1994-01-01

The authors analyze the influence of Sea Surface Temperature (SST) and surface wind divergence on atmospheric thermodynamic structure and the resulting effects on the occurrence of deep convection using National Meteorological Center radiosonde data and International Satellite Cloud Climatology Program data for July 1983-July 1985. The onset of deep convection requires not only the existence of positive convective available potential energy (CAPE), but also an unstable planetary boundary layer (PBL). A stable PBL is observed to suppress deep convection even when CAPE is positive. Variations of SST have a major effect on CAPE, but surface wind divergence can also affect deep convection by changing the lapse rate in the lower troposphere and humidity in the PBL. Specifically, when SST is greater than or equal to 28 C, CAPE is always positive, and surface wind divergence does not qualitatively change the buoyancy profile above the PBL. Strong surface wind divergence, however, stabilizes the PBL so as to suppress the initiation of deep convection. In warm SST regions, CAPE is greater than 0 regardless of assumptions about condensate loading, although the pseudoadiabatic limit is more consistent with the observed deep convection than the reversible moist-adiabatic limit under these circumstances. When SST is less than 27 C, CAPE is usually negative and inhibits convection, but strong surface wind convergence can destabilize the inversion layer and moisten the PBL enough to make the atmosphere neutrally stable in the mean. As a result, deep convection is generally enhanced either when SST is greater than or equal to 28 C in the absence of strong surface wind divergence or when strong surface wind convergence occurs even if SST is less than 27 C. The anomalous suppression of deep convection in the warm area of the equatorial west Pacific lying between the intertropical convergence zone (ITCZ) and south Pacific convergence zone (SPCZ) is probably caused by dryness in the PBL and an inversion in that area. The seasonal cycles of deep convection and surface wind divergence are in phase with the maximum solar radiation and lead SST for one to three months in the central Pacific. The change of PBL relative humidity plays a critical role in the changeover to convective instability in this case. The seasonal change of deep convection and associated clouds seems not to have important effects on the seasonal change of local SST in the central Pacific.

Bonded functional esthetic prototype: an alternative pre-treatment mock-up technique and cost-effective medium-term esthetic solution.

PubMed

McLaren, Edward A

2013-09-01

As the economy has receded in recent years, many patients have been inclined to reject dental treatment beyond what they feel is the minimal amount necessary. Increasingly, there has been reluctance to take on the expense of full-mouth restorations and time-consuming procedures. Consequently, clinicians can benefit from innovative, conservative, interim solutions that enable them to provide segment treatment with long-term stability and esthetics, with lower initial cost. The bonded functional esthetic prototype (BFEP) allows fabrication of up to 14 teeth from composite in 1 hour, providing either a pre-treatment restoration or a long-term provisional solution until further treatment can be completed. As demonstrated herein, the BFEP enables superb function, stability, and esthetics in the interim while dispersing the cost of definitive treatment over time.

Possible influence of dust on hurricane genesis

NASA Astrophysics Data System (ADS)

Bretl, Sebastian; Reutter, Philipp; Raible, Christoph C.; Ferrachat, Sylvaine; Lohmann, Ulrike

2014-05-01

Tropical Cyclones (TCs) belong to the most extreme events in nature. In the past decade, the possible impact of dust on Atlantic hurricanes receives growing interest. As mineral dust is able to absorb incoming solar radiation and therefore warm the surrounding air, the presence of dust can lead to a reduction of sea surface temperature (SST) and an increase in atmospheric stability. Furthermore, resulting baroclinic effects and the dry Saharan easterly jet lead to an enhanced vertical shear of the horizontal winds. SST, stability, moisture and vertical wind shear are known to potentially impact hurricane activity. But how Saharan dust influences these prerequisites for hurricane formation is not yet clear. Some dynamical mechanisms induced by the SAL might even strengthen hurricanes. An adequate framework for investigating the possible impact of dust on hurricanes is comparing high resolution simulations (~0.5°x0.5°, 31 vertical levels) with and without radiatively active dust aerosols. To accomplish this task, we are using the general circulation model ECHAM6 coupled to a modified version of the aerosol model HAM, ECHAM6-HAM-Dust. Instead of the five aerosol species HAM normally contains, the modified version takes only insoluble dust into account, but modifies the scavenging parameters in order to have a similar lifetime of dust as in the full ECHAM6-HAM. All remaining aerosols are prescribed. To evaluate the effects of dust on hurricanes, a TC detection and tracking method is applied on the results. ECHAM6-HAM-Dust was used in two configurations, one with radiatively active dust aerosols and one with dust being not radiatively active. For both set-ups, 10 Monte-Carlo simulations of the year 2005 were performed. A statistical method which identifies controlling parameters of hurricane genesis was applied on North Atlantic developing and non-developing disturbances in all simulations, comparing storms in the two sets of simulations. Hereby, dust can be assigned a more influencing role on TC genesis in the simulations with active dust. Despite dust is seeming to have a negative influence on TC genesis, the relative importance of dust compared to the sea surface temperature (SST) cannot be determined thoroughly. This is largely due to a similar pattern of SST and dust off the west coast of Africa, so that possible effects of dust and SST could hardly be separated.

Progress on plutonium stabilization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hurt, D.

1996-05-01

The Defense Nuclear Facilities Safety Board has safety oversight responsibility for most of the facilities where unstable forms of plutonium are being processed and packaged for interim storage. The Board has issued recommendations on plutonium stabilization and has has a considerable influence on DOE`s stabilization schedules and priorities. The Board has not made any recommendations on long-term plutonium disposition, although it may get more involved in the future if DOE develops plans to use defense nuclear facilities for disposition activities.

18 CFR 11.17 - Procedures for payment of charges and costs.

Code of Federal Regulations, 2010 CFR

2010-04-01

... charge is established for a period for which an interim charge was paid, the Commission will apply the... hydrology, development, and other characteristics of the river basin, demonstrate sufficient stability to...

18 CFR 11.17 - Procedures for payment of charges and costs.

Code of Federal Regulations, 2011 CFR

2011-04-01

... charge is established for a period for which an interim charge was paid, the Commission will apply the... hydrology, development, and other characteristics of the river basin, demonstrate sufficient stability to...

46 CFR 178.330 - Simplified stability proof test (SST).

Code of Federal Regulations, 2014 CFR

2014-10-01

... the vertical center of gravity, causing the least stable condition that is likely to occur in service... center of gravity are to be assumed as follows: (i) The weight of primary lifesaving equipment should be... center of gravity of variable loads must be included as appropriate for the service intended and...

46 CFR 178.330 - Simplified stability proof test (SST).

Code of Federal Regulations, 2013 CFR

2013-10-01

... the vertical center of gravity, causing the least stable condition that is likely to occur in service... center of gravity are to be assumed as follows: (i) The weight of primary lifesaving equipment should be... center of gravity of variable loads must be included as appropriate for the service intended and...

46 CFR 178.330 - Simplified stability proof test (SST).

Code of Federal Regulations, 2012 CFR

2012-10-01

... the vertical center of gravity, causing the least stable condition that is likely to occur in service... center of gravity are to be assumed as follows: (i) The weight of primary lifesaving equipment should be... center of gravity of variable loads must be included as appropriate for the service intended and...

Diurnal warming impacts on atmospheric and oceanic evolution during the suppressed phase of the Madden Julian Oscillation

NASA Astrophysics Data System (ADS)

Clayson, C. A.; Roberts, J.

2016-02-01

The Madden-Julian Oscillation (MJO) represents a prominent mode of intraseasonal tropical variability as manifest by coherent large-scale changes in atmospheric circulation, convection, and thermodynamic processes. Its impacts are far-reaching with influences on monsoons, flooding, droughts, and tropical storms. The characteristic timescale of the MJO is positioned in a gap between synoptic forecasting and longer range seasonal to interannual predictions, but has been shown to be dependent on diurnally-varying sea surface temperature (SST). In this work, we leverage a wide suite of satellite products with in situ oceanographic data over the 2002-2012 period to investigate the rectification effects of strong ocean diurnal warming onto the development of intraseasonal SST variability, and whether there a detectable influence on the diurnal cycle of cloud-radiative effects in the suppressed phase of the MJO. Diurnally-varying SST is used as a conditional sampling parameter, along with AIRS/AMSU-A temperature and moisture profiles, surface winds, radiative and turbulent surface fluxes, and precipitation. We use composite daily average atmospheric BL depths, changes in lower-tropospheric stability, and moist static energy to evaluate changes in convective inhibition based on the diurnal variability of surface parcel characteristics due to turbulent heat fluxes, and compare with diurnal changes in cloud-radiative effects and precipitation. Argo floats and ocean modeling experiments are used to examine the upper ocean response. An ensemble of MJO simulations are generated using Argo profiles and satellite-derived surface forcing from which the systematic impacts of diurnal variability on the generation of the intraseasonal SST warming are evaluated. These simulations inform the importance of diurnal variations in surface boundary forcing to upper ocean mixing and the integrated contribution to SST warming over the typical duration of a suppressed phase of the MJO.

A Time Series of Mean Global Sea Surface Temperature from the Along-Track Scanning Radiometers

NASA Astrophysics Data System (ADS)

Veal, Karen L.; Corlett, Gary; Remedios, John; Llewellyn-Jones, David

2010-12-01

A climate data set requires a long time series of consistently processed data with suitably long periods of overlap of different instruments which allows characterization of any inter-instrument biases. The data obtained from ESA's three Along-Track Scanning Radiometers (ATSRs) together comprise an 18 year record of SST with overlap periods of at least 6 months. The data from all three ATSRs has been consistently processed. These factors together with the stability of the instruments and the precision of the derived SST makes this data set eminently suitable for the construction of a time series of SST that complies with many of the GCOS requirements for a climate data set. A time series of global and regional average SST anomalies has been constructed from the ATSR version 2 data set. An analysis of the overlap periods of successive instruments was used to remove intra-series biases and align the series to a common reference. An ATSR climatology has been developed and has been used to calculate the SST anomalies. The ATSR-1 time series and the AATSR time series have been aligned to ATSR-2. The largest adjustment is ~0.2 K between ATSR-2 and AATSR which is suspected to be due to a shift of the 12 μm filter function for AATSR. An uncertainty of 0.06 K is assigned to the relative anomaly record that is derived from the dual three-channel night-time data. A relative uncertainty of 0.07 K is assigned to the dual night-time two-channel record, except in the ATSR-1 period (1994-1996) where it is larger.

Evidence of bottom-up limitations in nearshore marine systems based on otolith proxies of fish growth

USGS Publications Warehouse

von Biela, Vanessa R.; Kruse, Gordon H.; Mueter, Franz J.; Black, Bryan A.; Douglas, David C.; Helser, Thomas E.; Zimmerman, Christian E.

2015-01-01

Fish otolith growth increments were used as indices of annual production at nine nearshore sites within the Alaska Coastal Current (downwelling region) and California Current (upwelling region) systems (~36–60°N). Black rockfish (Sebastes melanops) and kelp greenling (Hexagrammos decagrammus) were identified as useful indicators in pelagic and benthic nearshore food webs, respectively. To examine the support for bottom-up limitations, common oceanographic indices of production [sea surface temperature (SST), upwelling, and chlorophyll-a concentration] during summer (April–September) were compared to spatial and temporal differences in fish growth using linear mixed models. The relationship between pelagic black rockfish growth and SST was positive in the cooler Alaska Coastal Current and negative in the warmer California Current. These contrasting growth responses to SST among current systems are consistent with the optimal stability window hypothesis in which pelagic production is maximized at intermediate levels of water column stability. Increased growth rates of black rockfish were associated with higher chlorophyll concentrations in the California Current only, but black rockfish growth was unrelated to the upwelling index in either current system. Benthic kelp greenling growth rates were positively associated with warmer temperatures and relaxation of downwelling (upwelling index near zero) in the Alaska Coastal Current, while none of the oceanographic indices were related to their growth in the California Current. Overall, our results are consistent with bottom-up forcing of nearshore marine ecosystems—light and nutrients constrain primary production in pelagic food webs, and temperature constrains benthic food webs.

Somatostatin and its receptors contribute in a tissue-specific manner to the sex-dependent metabolic (fed/fasting) control of growth hormone axis in mice

PubMed Central

Córdoba-Chacón, José; Gahete, Manuel D.; Castaño, Justo P.; Kineman, Rhonda D.

2011-01-01

Somatostatin (SST) inhibits growth hormone (GH) secretion and regulates multiple processes by signaling through its receptors sst1–5. Differential expression of SST/ssts may contribute to sex-specific GH pattern and fasting-induced GH rise. To further delineate the tissue-specific roles of SST and sst1–5 in these processes, their expression patterns were evaluated in hypothalamus, pituitary, and stomach of male and female mice under fed/fasted conditions in the presence (wild type) or absence (SST-knockout) of endogenous SST. Under fed conditions, hypothalamic/stomach SST/ssts expression did not differ between sexes, whereas male pituitary expressed more SST and sst2A/2B/3/5A/5TMD2/5TMD1 and less sst1, and male pituitary cell cultures were more responsive to SST inhibitory actions on GH release compared with females. This suggests that local pituitary SST/ssts can contribute to the sexually dimorphic pattern of GH release. Fasting (48 h) reduced stomach sst2A/B and hypothalamic SST/sst2A expression in both sexes, whereas it caused a generalized downregulation of pituitary sst subtypes in male and of sst2A only in females. Thus, fasting can reduce SST sensitivity across tissues and SST input to the pituitary, thereby jointly contributing to enhance GH release. In SST-knockout mice, lack of SST differentially altered sst subtype expression levels in both sexes, supporting an important role for SST in sex-dependent control of GH axis. Evaluation of SST, IGF-I, and glucocorticoid effects on hypothalamic and pituitary cell cultures revealed that these hormones could directly account for alterations in sst2/5 expression in the physiological states examined. Taken together, these results indicate that changes in SST output and sensitivity can contribute critically to precisely define, in a tissue-dependent manner, the sex-specific metabolic regulation of the GH axis. PMID:20943754

Idealized modeling of convective organization with changing sea surface temperatures using multiple equilibria in weak temperature gradient simulations

NASA Astrophysics Data System (ADS)

Sentić, Stipo; Sessions, Sharon L.

2017-06-01

The weak temperature gradient (WTG) approximation is a method of parameterizing the influences of the large scale on local convection in limited domain simulations. WTG simulations exhibit multiple equilibria in precipitation; depending on the initial moisture content, simulations can precipitate or remain dry for otherwise identical boundary conditions. We use a hypothesized analogy between multiple equilibria in precipitation in WTG simulations, and dry and moist regions of organized convection to study tropical convective organization. We find that the range of wind speeds that support multiple equilibria depends on sea surface temperature (SST). Compared to the present SST, low SSTs support a narrower range of multiple equilibria at higher wind speeds. In contrast, high SSTs exhibit a narrower range of multiple equilibria at low wind speeds. This suggests that at high SSTs, organized convection might occur with lower surface forcing. To characterize convection at different SSTs, we analyze the change in relationships between precipitation rate, atmospheric stability, moisture content, and the large-scale transport of moist entropy and moisture with increasing SSTs. We find an increase in large-scale export of moisture and moist entropy from dry simulations with increasing SST, which is consistent with a strengthening of the up-gradient transport of moisture from dry regions to moist regions in organized convection. Furthermore, the changes in diagnostic relationships with SST are consistent with more intense convection in precipitating regions of organized convection for higher SSTs.

The Influence of Midlatitude Ocean-Atmosphere Coupling on the Low-Frequency Variability of a GCM. Part I: No Tropical SST Forcing*.

NASA Astrophysics Data System (ADS)

Bladé, Ileana

1997-08-01

This study examines the extent to which the thermodynamic interactions between the midlatitude atmosphere and the underlying oceanic mixed layer contribute to the low-frequency atmospheric variability. A general circulation model, run under perpetual northern winter conditions, is coupled to a motionless constant-depth mixed layer in midlatitudes, while elsewhere the sea surface temperature (SST) is kept fixed; interannual tropical SST forcing is not included. It is found that coupling does not modify the spatial organization of the variability. The influence of coupling is manifested as a slight reddening of the spectrum of 500-mb geopotential height and a significant enhancement of the lower-tropospheric thermal variance over the oceans at very low frequencies by virtue of the mixed-layer adjustment to surface air temperature variations that occurs on those timescales. This adjustment effectively reduces the thermal damping of the atmosphere associated with surface heat fluxes (or negative oceanic feedback), thus increasing the thermal variance and the persistence of circulation anomalies.In studying the covariability between ocean and atmosphere it is found that the dominant mode of natural atmospheric variability is coupled to the leading mode of SST in each ocean, with the atmosphere leading the ocean by about one month. The cross-correlation function between oceanic and atmospheric anomalies is strongly asymmetric about zero lag. The SST structures are consistent with direct forcing by the anomalous heat fluxes implied by the concurrent surface air temperature and wind fluctuations. Additionally, composites based on large amplitude SST anomaly events contain no evidence of direct driving of atmospheric perturbations by these SST anomalies. Thus, in terms of the spatial organization of the covariability and the evolution of the coupled system from one regime to another, large-scale air-sea interaction in the model is characterized by one-way atmospheric forcing of the mixed layer.These results are qualitatively consistent with those from an earlier idealized study. They imply a subtle but fundamental role for the midlatitude oceans as stabilizing rather than directly generating atmospheric anomalies. It is argued that this scenario is relevant to the dynamics of extratropical atmosphere-ocean coupling on intraseasonal timescales at least: the model is able to qualitatively reproduce the temporal and spatial characteristics of the observed dominant patterns of interaction on these timescales, particularly over the Atlantic.

Emerging Technologies for the Remediation of Metals in Soils, Insitu Stabilization/Inplace Inactivation

DTIC Science & Technology

1997-12-01

implement, they may also serve as interim measures for reducing risk prior to subsequent phytoremediation or remediation by other techniques. 2.0...are essentially non-leachable and pass leachate and TCLP testing protocols. 2.6 Time Requirements Most of the stabilization techniques mentioned above...site. In addition to the attractive low cost of both phytoremediation techniques, these techniques may also be less invasive and more quickly

Dynamical diagnostics of the SST annual cycle in the eastern equatorial Pacific: part I a linear coupled framework

NASA Astrophysics Data System (ADS)

Chen, Ying-Ying; Jin, Fei-Fei

2018-03-01

The eastern equatorial Pacific has a pronounced westward propagating SST annual cycle resulting from ocean-atmosphere interactions with equatorial semiannual solar forcing and off-equatorial annual solar forcing conveyed to the equator. In this two-part paper, a simple linear coupled framework is proposed to quantify the internal dynamics and external forcing for a better understanding of the linear part of the dynamics annual cycle. It is shown that an essential internal dynamical factor is the SST damping rate which measures the coupled stability in a similar way as the Bjerknes instability index for the El Niño-Southern Oscillation. It comprises three major negative terms (dynamic damping due to the Ekman pumping feedback, mean circulation advection, and thermodynamic feedback) and two positive terms (thermocline feedback and zonal advection). Another dynamical factor is the westward-propagation speed that is mainly determined by the thermodynamic feedback, the Ekman pumping feedback, and the mean circulation. The external forcing is measured by the annual and semiannual forcing factors. These linear internal and external factors, which can be estimated from data, determine the amplitude of the annual cycle.

AATSR - Precise Sea-Surface Temperature for Climate Monitoring and for Operational Applications

NASA Astrophysics Data System (ADS)

Llewellyn-Jones, David; Corlett, Gary; Donlon, Craig; Stark, John

The Advanced Along-Track Scanning Radiometer (AATSR) is an imaging radiometer specifi- cally designed to measure Sea-Surface Temperature (SST) to the demanding levels of accuracy and stability required for climate research. AATSR, which has been operating continuously on ESA's Envisat Satellite since its launch in 2002, achieves the required levels of accuracy on account of its unique dual view, whereby each terrestrial scene is viewed twice, once at nadir and then through an inclined path which uses a different atmospheric path-length, thereby providing a direct observation of atmospheric effects, leading to an exceptionally accurate atmospheric correction. This feature is accompanied by an advanced calibration system combined with excellent optical and thermal designs. Recent rigorous and extensive comparisons with in situ data have shown that, for most of the global oceans, AATSR can achieve and accuracy of around 0.2o C with high stability, which has qualified them for use in climate analysis schemes. Because AATSR is the third sensor in a near-continuous series which started with the launch of ATSR-1 on ERS-1 satellite in 1991, there is a time-series of 16+ years of climate standard SSTs which have recently been re-processed and are now becoming available to the World-wide user community from data centres in Europe. SST data from AATSR have been included in the suite of operational SST products generated by the GODAE/GHRSST Pilot Project, on a timescale needed by operational users and in a format which allows easy ingestion and error estimates for data from AATSR and most of the other sensors currently providing SST measurements from space. Within the GODAE/GHRSST data-products, AATSR SST data are generally regarded as the benchmark for accuracy and are used to provide bias corrections for data from the other sensors, which often have superior coverage, thus exploiting synergistically the complementary qualities if the different data-sets. The UK Met Office use GODAE/GHRSST data to generate a daily Operational Sea Surface Temperature and Sea Ice Analysis (OSTIA). This analysis has been evaluated by the Met Office for use in their Numerical Weather Prediction (NWP) Scheme. The AATSR sensor, recent validation results and the OSTIA system will be briefly described. Also, the initial results of an on-going evaluation of AATSR error statistics, as presented in GHRSST data, as well as the impact of AATSR accuracy on the OSTIA performance, will be briefly discussed.

46 CFR 178.330 - Simplified stability proof test (SST).

Code of Federal Regulations, 2011 CFR

2011-10-01

... limits of heel: (1) On a flush deck vessel, not more than one-half of the freeboard may be immersed. (2... is less, may be immersed. (7) In no case may the angle of heel exceed 14 degrees. (e) The limits of heel must be measured at: (1) The point of minimum freeboard; or (2) At a point three-quarters of the...

Understanding tropical upper tropospheric warming: The role of SSTs, convective parameterizations, and observational uncertainties

NASA Astrophysics Data System (ADS)

Po-Chedley, S.; Thorsen, T. J.; Fu, Q.

2015-12-01

Recent research has compared CMIP5 general circulation model (GCM) simulations with satellite observations of warming in the tropical upper troposphere relative to the lower-middle troposphere. Although the pattern of SST warming is important, this research demonstrated that models overestimate increases in static stability between the mid- to upper- tropical troposphere, even when they are forced with historical sea surface temperatures. This discrepancy between satellite-borne microwave sounding unit measurements (MSU) and GCMs is important because it has implications for the strength of the lapse rate and water vapor feedback. The apparent model-observational difference for changes in static stability in the tropical upper troposphere represents an important problem, but it is not clear whether the difference is a result of common biases in GCMs, biases in observational datasets, or both. In this work, we will use GCM simulations to examine the importance of the spatial pattern of SST warming and different convective parameterizations in determining the lapse rate changes in tropical troposphere. We will also consider uncertainties in MSU satellite observations, including changes in the diurnal sampling of temperature and instrument calibration biases when comparing GCMs with the observed record.

Evaluation of experimental flexible pavements : interim report no. 1, construction of Altavista Bypass experimental pavement.

DOT National Transportation Integrated Search

1974-01-01

Deflection tests conducted during the construction and shortly after the completion of a large experimental pavement project are reported. Four different pavement designs, as follows, are compared: 1. 6-inch cement stabilized subgrade, 6-inch crushed...

Power and Energy Management Strategy for Solid State Transformer Interfaced DC Microgrid

NASA Astrophysics Data System (ADS)

Yu, Xunwei

As a result of more and more applications of renewable energy into our ordinary life, how to construct a microgrid (MG) based on the distributed renewable energy resources and energy storages, and then to supply a reliable and flexible power to the conventional power system are the hottest topics nowadays. Comparing to the AC microgrid (AC MG), DC microgrid (DC MG) gets more attentions, because it has its own advantages, such as high efficiency, easy to integrate the DC energy sources and energy storages, and so on. Furthermore, the interaction between DC MG system and the distribution system is also an important and practical issue. In Future Renewable Electric Energy Delivery and Management Systems Center (FREEDM), the Solid State Transformer (SST) is built, which can transform the distribution system to the low AC and DC system directly (usually home application level). Thus, the SST gives a new promising solution for low voltage level MG to interface the distribution level system instead of the traditional transformer. So a SST interfaced DC MG is proposed. However, it also brings new challenges in the design and control fields for this system because the system gets more complicated, which includes distributed energy sources and storages, load, and SST. The purpose of this dissertation is to design a reliable and flexible SST interfaced DC MG based on the renewable energy sources and energy storages, which can operate in islanding mode and SST-enabled mode. Dual Half Bridge (DHB) is selected as the topology for DC/DC converter in DC MG. The DHB operation procedure and average model are analyzed, which is the basis for the system modeling, control and operation. Furthermore, two novel power and energy management strategies are proposed. The first one is a distributed energy management strategy for the DC MG operating in the SST-enabled mode. In this method, the system is not only in distributed control to increase the system reliability, but the power sharing between DC MG and SST, State of Charge (SOC) for battery, are both considered in the system energy management strategy. Then the DC MG output power is controllable and the battery is autonomous charged and discharged based on its SOC and system information without communication. The system operation modes are defined, analyzed and the simulation results verify the strategy. The second power and energy management strategy is the hierarchical control. In this control strategy, three-layer control structure is presented and defined. The first layer is the primary control for the DC MG in islanding mode, which is to guarantee the DC MG system power balance without communication to increase the system reliability. The second control layer is to implement the seamless switch for DC MG system from islanding mode to SST-enabled mode. The third control layer is the tertiary control for the system energy management and the communication is also involved. The tertiary layer not only controls the whole DC MG output power, but also manages battery module charge and discharge statuses based on its SOC. The simulation and experimental results verify the methods. Some practical issues for the SST interfaced DC MG are also investigated. Power unbalance issue of SST is analyzed and a distributed control strategy is presented to solve this problem. Simulation and experimental results verify it. Furthermore, the control strategy for SST interfaced DC MG blackout is presented and the simulation results are shown to valid it. Also a plug and play SST interfaced DC MG is constructed and demonstrated. Several battery and PV modules construct a typical DC MG and a DC source is adopted to simulate the SST. The system is in distributed control and can operate in islanding mode and SST-enabled mode. The experimental results verify that individual module can plug into and unplug from the DC MG randomly without affecting the system stability. Furthermore, the communication ports are embedded into the system and a universal communication protocol is proposed to implement the plug and play function. Specified ID is defined for individual PV and battery for system recognition. A database is built to store the whole system date for visual display, monitor and history query.

A virtual reality application in role-plays of social skills training for schizophrenia: a randomized, controlled trial.

PubMed

Park, Kyung-Min; Ku, Jeonghun; Choi, Soo-Hee; Jang, Hee-Jeong; Park, Ji-Yeon; Kim, Sun I; Kim, Jae-Jin

2011-09-30

Although social skills training (SST) is an effective approach for improving social skills for schizophrenia, the motivational deficit attenuates its efficacy. Virtual reality (VR) applications have allowed individuals with mental disabilities to enhance their motivation for rehabilitation. We compared SST using VR role-playing (SST-VR) to SST using traditional role-playing (SST-TR). This randomized, controlled trial included 91 inpatients with schizophrenia who were assigned to either SST-VR (n=46) or SST-TR (n=45). Both groups were administered over 10 semiweekly group sessions. An experienced, blinded rater assessed vocal, nonverbal and conversational skills. We also obtained data on motivation for SST and various social abilities. Throughout the 10 sessions, the SST-VR group (n=33) showed greater interest in SST and generalization of the skills than the SST-TR group (n=31). After SST, the SST-VR group improved more in conversational skills and assertiveness than the SST-TR group, but less in nonverbal skills. The VR application in role-plays of SST for schizophrenia may be particularly beneficial in terms of improving the conversational skills and assertiveness, possibly through its advantages in enhancing motivation for SST and generalization of the skills, and thus it may be a useful supplement to traditional SST. Copyright © 2011 Elsevier Ltd. All rights reserved.

Local and large-scale atmospheric responses to reduced Arctic sea ice and ocean warming in the WRF model

NASA Astrophysics Data System (ADS)

Porter, David F.; Cassano, John J.; Serreze, Mark C.

2012-06-01

The Weather Research and Forecasting (WRF) model is used to explore the sensitivity of the large-scale atmospheric energy and moisture budgets to prescribed changes in Arctic sea ice and sea surface temperatures (SSTs). Observed sea ice fractions and SSTs from 1996 and 2007, representing years of high and low sea ice extent, are used as lower boundary conditions. A pan-Arctic domain extending into the North Pacific and Atlantic Oceans is used. ERA-Interim reanalysis data from 1994 to 2008 are employed as initial and lateral forcing data for each high and low sea ice simulation. The addition of a third ensemble, with a mixed SST field between years 1996 and 2007 (using 2007 SSTs above 66°N and 1996 values below), results in a total of three 15-member ensembles. Results of the simulations show both local and remote responses to reduced sea ice. The local polar cap averaged response is largest in October and November, dominated by increased turbulent heat fluxes resulting in vertically deep heating and moistening of the Arctic atmosphere. This warmer and moister atmosphere is associated with an increase in cloud cover, affecting the surface and atmospheric energy budgets. There is an enhancement of the hydrologic cycle, with increased evaporation in areas of sea ice loss paired with increased precipitation. Most of the Arctic climate response results from within-Arctic changes, although some changes in the hydrologic cycle reflect circulation responses to midlatitude SST forcing, highlighting the general sensitivity of the Arctic climate.

Factors affecting the simulated trajectory and intensification of Tropical Cyclone Yasi (2011)

NASA Astrophysics Data System (ADS)

Parker, Chelsea L.; Lynch, Amanda H.; Mooney, Priscilla A.

2017-09-01

This study investigates the sensitivity of the simulated trajectory, intensification, and forward speed of Tropical Cyclone Yasi to initial conditions, physical parameterizations, and sea surface temperatures. Yasi was a category 5 storm that made landfall in Queensland, Australia in February 2011. A series of simulations were performed using WRF-ARW v3.4.1 driven by ERA-Interim data at the lateral boundaries. To assess these simulations, a new simple skill score is devised to summarize the deviation from observed conditions at landfall. The results demonstrate the sensitivity to initial condition resolution and the need for a new initialization dataset. Ensemble testing of physics parameterizations revealed strong sensitivity to cumulus schemes, with a trade-off between trajectory and intensity accuracy. The Tiedtke scheme produces an accurate trajectory evolution and landfall location. The Kain Fritch scheme is associated with larger errors in trajectory due to a less active shallow convection over the ocean, leading to warmer temperatures at the 700 mb level and a stronger, more poleward steering flow. However, the Kain Fritsch scheme produces more accurate intensities and translation speeds. Tiedtke-derived intensities were weaker due to suppression of deep convection by active shallow convection. Accurate representation of the sea surface temperature through correcting a newly discovered SST lag in reanalysis data or increasing resolution of SST data can improve the simulation. Higher resolution increases relative vorticity and intensity. However, the sea surface boundary had a more pronounced effect on the simulation with the Tiedtke scheme due to its moisture convergence trigger and active shallow convection over the tropical ocean.

Laboratory evaluation of flyash treated embankment and base materials : interim report No. 1.

DOT National Transportation Integrated Search

1986-06-01

This study was undertaken to provide the Louisiana DOTD with a data base from which decision-making information can be concerning the modification or stabilization of soils using flyash as a full or partial replacement for hydraulic cement or hydrate...

77 FR 4674 - State Fiscal Stabilization Fund Program

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-31

... and competing priorities that States were facing in meeting the SFSF data collection and reporting... the interim final requirement (i.e., the notice of proposed revisions to certain data collection and... collection instructions; respondents can provide the requested data in the desired format; reporting burden...

Somatostatin and its 2A receptor in dorsal root ganglia and dorsal horn of mouse and human: expression, trafficking and possible role in pain

PubMed Central

2014-01-01

Background Somatostatin (SST) and some of its receptor subtypes have been implicated in pain signaling at the spinal level. In this study we have investigated the role of SST and its sst2A receptor (sst2A) in dorsal root ganglia (DRGs) and spinal cord. Results SST and sst2A protein and sst2 transcript were found in both mouse and human DRGs, sst2A-immunoreactive (IR) cell bodies and processes in lamina II in mouse and human spinal dorsal horn, and sst2A-IR nerve terminals in mouse skin. The receptor protein was associated with the cell membrane. Following peripheral nerve injury sst2A-like immunoreactivity (LI) was decreased, and SST-LI increased in DRGs. sst2A-LI accumulated on the proximal and, more strongly, on the distal side of a sciatic nerve ligation. Fluorescence-labeled SST administered to a hind paw was internalized and retrogradely transported, indicating that a SST-sst2A complex may represent a retrograde signal. Internalization of sst2A was seen in DRG neurons after systemic treatment with the sst2 agonist octreotide (Oct), and in dorsal horn and DRG neurons after intrathecal administration. Some DRG neurons co-expressed sst2A and the neuropeptide Y Y1 receptor on the cell membrane, and systemic Oct caused co-internalization, hypothetically a sign of receptor heterodimerization. Oct treatment attenuated the reduction of pain threshold in a neuropathic pain model, in parallel suppressing the activation of p38 MAPK in the DRGs Conclusions The findings highlight a significant and complex role of the SST system in pain signaling. The fact that the sst2A system is found also in human DRGs and spinal cord, suggests that sst2A may represent a potential pharmacologic target for treatment of neuropathic pain. PMID:24521084

Characteristics of tropical clouds using A-train information and their relationships with sea surface temperature

NASA Astrophysics Data System (ADS)

Behrangi, A.; Kubar, T. L.; Lambrigtsen, B.

2011-12-01

Different cloud types have substantially different characteristics in terms of radiative forcing and microphysical properties, both important components of Earth's climate system. Relationships between tropical cloud type characteristics and sea surface temperature (SST) using two-years of A-train data are investigated in this presentation. Stratocumulus clouds are the dominant cloud type over SSTs less than 301K, and in fact their fraction is strongly inversely related to SST. This is physically logical as both static stability and large-scale subsidence scale well with decreasing SST. At SSTs greater than 301K, high clouds are the most abundant cloud type. All cloud types (except nimbostratus and stratocumulus) become sharply more abundant for SSTs greater than a window between 299K and 300.5K, depending on cloud type. The fraction of high, deep convective, altostratus, and altocumulus clouds peak at an SST close to 303K, while cumulus clouds have a broad cloud fraction peak centered near 301K. Deep convective and other high cloud types decrease sharply above SSTs of 303K. While overall early morning clouds are 10% (4%) more frequent than afternoon clouds as indicated by CloudSat (lidar-radar), certain cloud types occur more frequently in the early afternoon, such as high clouds. We also show that a large amount of warm precipitation mainly from stratocumulus clouds is missed or significantly underestimated by the current suite of satellite-based global precipitation measuring sensors. However, the operational sensitivity of Cloudsat cloud profiling radar permits to capture significant fraction of light drizzle and warm rain.

Field trial of gravel stabilization methods : Route 1, Cyr-Van Buren, ME : 2nd interim report.

DOT National Transportation Integrated Search

1995-02-01

This experimental construction project was developed, designed, and inspected by personnel from the University of Maine, Civil Engineering Staff. The experimental project was constructed on and as a part of Project #2586 00. This was a complete recon...

Field trial of gravel stabilization methods : Route 1, Cyr-Van Buren, ME : 1st interim report.

DOT National Transportation Integrated Search

1993-05-01

This experimental construction project was developed, designed, and inspected by personnel from the University of Maine, Civil Engineering Staff. The experimental project was constructed on and as a part of Project #2586.00. This was a complete recon...

In-place cement stabilized base reconstruction techniques interim report : "construction and two year evaluation".

DOT National Transportation Integrated Search

2002-08-01

The purpose of this research was to evaluate the effectiveness of soil cement shrinkage crack mitigation techniques. The contents of this report reflect an evaluation of the construction of the test sections and a two-year evaluation of the test sect...

In-place cement stabilized base reconstruction techniques interim report, "construction and two year evaluation" : technical summary.

DOT National Transportation Integrated Search

2002-08-01

The purpose of this research is to evaluate the effectiveness of soil cement shrinkage crack mitigation techniques. Ten test sections, 1000 feet long, were constructed on LA 89 in Vermilion Parish. The shrinkage crack mitigation methods being evaluat...

Clean Break

ERIC Educational Resources Information Center

Peterson, Erin

2011-01-01

An interim president has to perform a particularly difficult balancing act. He or she shoulders the burdens from--or legacy of--the previous president and must also provide a foundation of stability for the new president. Throughout the process, effective communication--both internally and externally--is critical to ensuring a smooth transition.…

A study on bulk and skin temperature difference using observations from Atlantic and Pacific Coastal regions of United States

NASA Astrophysics Data System (ADS)

Alappattu, Denny P.; Wang, Qing; Yamaguchi, Ryan; Lind, Richard; Reynolds, Mike; Christman, Adam

2017-05-01

Analysis of bulk-skin sea surface temperature (SST) difference form the west and east coasts of United States is presented using the data collected from three field experiments. These experiments were conducted at offshore Duck, North Carolina and in the Monterey Bay of the California coastal region. Bulk SST measurements were made using conventional thermistors from a depth of one meter below the sea level. Infrared radiometers were used to measure the surface skin SST. Depending on measurement depth and prevailing conditions, the bulk SST can differ from skin SST by few tenths of a degree to O(1°C). Difference between bulk and skin SST arise from cools skin and warm layer effects. Bulk-skin SST difference (ΔSST) estimated from east coast observations varied from -0.46°C to 1.24°C. Here, the bulk SST was higher than skin SST most of the time during the observations. This indicates cool skin effect was the dominant factor determining the ΔSST in the east coast. For wind speeds less than 4 m s-1, we also noticed an increase in ΔSST. Additionally, for low winds (<4 m s-1) ΔSST also varied diurnally with the occurrence of generally higher ΔSST in the nighttime in comparison with daytime. Moreover, increase in downwelling longwave radiation reduced the bulk-skin SST difference. ΔSST calculated from the observation in the Monterey bay varied between 2.3° and -2.3°C. This was higher than the variability ΔSST observed at the east coast. Moreover, ΔSST variability observed at west coast was independent of wind speed.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chan, R.K.; Otte, C.A.

Saccharomyces cerevisiae MATa cells carrying mutations in either sst1 or sst2 are supersensitive to the G1 arrest induced by ..cap alpha.. factor pheromone. When sst1 mutants were mixed with normal SST/sup +/ cells, the entire population recovered together from ..cap alpha.. factor arrest, suggesting that SST/sup +/ cells helped sst1 mutants to recover. Complementation tests and linkage analysis showed that sst1 and bar1, a mutation which eliminates the ability of MATa cells to act as a ''barrier'' to the diffusion of ..cap alpha.. factor, were lesions in the same genes. These findings suggest that sst1 mutants are defective in recoverymore » from ..cap alpha.. factor arrest because they are unable to degrade the pheromone. In contrast, recovery of sst2 mutants was not potentiated by the presence of SST/sup +/ cells in mixing experiments. When either normal MATa cells or mutant cells carrying defects in sst1 or sst2 were exposed to ..cap alpha.. factor for 1 h and then washed free of the pheromone, the sst2 cells subsequently remained arrested in the absence of ..cap alpha.. factor for a much longer time than SST/sup +/ or sst1 cells. These observations suggest that the defect in sst2 mutants is intrinsic to the cell and is involved in the mechanism of ..cap alpha.. factor action at some step after the initial interaction of the pheromone with the cell. The presence of an sst2 mutation appears to cause a growth debility, since repeated serial subculture of haploid sst2-1 strains led to the accumulation of faster-growing revertants that were pheromone resistant and were mating defective (''sterile'').« less

How well do Reanalysis represent polar lows?

NASA Astrophysics Data System (ADS)

Zappa, G.; Shaffrey, L.; Hodges, K.

2013-12-01

Polar lows are intense maritime mesocyclones forming at high latitudes during polar air outbreaks. The associated high surface winds can be an important cause of coastal damage.They also seem to play a relevant role in the climate system by modulating the oceanic surface heat fluxes. This creates strong interest in understanding whether modern reanalysis datasets are able to represent polar lows, as well as how their representation may be sensitive to the model resolution. In this talk we investigate how ERA-Interim reanalysis represents the polar lows identified by the Norwegian meteorological services and listed in the STARS (Combination of Sea Surface Temperature and AltimeteR Synergy) dataset for the period 2002-2011. The sensitivity to resolution is explored by comparing ERA-Interim to the ECMWF operational analyses (2008-2011), which have three times higher horizontal resolution compared to ERA-Interim. We show that ERAI-Interim has excellent ability to capture the observed polar lows events with up to 90% of the observed events being found in the reanalysis. However, ERA-Interim tends to have polar lows of weaker dynamical intensity, in terms of both winds and vorticity, and with less spatial structure than in the ECMWF operational analyses (See Fig 1). Furthermore, we apply an objective feature tracking algorithm to the 3 hourly vorticity at 850 hPa with constraints on vorticity intensity and atmospheric static stability to objectively identify polar lows in the ERA-Interim reanalysis. We show that for the stronger polar lows the objective climatology shows good agreement with the STARS dataset over the 2002-2011 period. This allows us to extend the polar lows climatology over the whole ERA Interim period. Differences with another reanalysis product (NCEP-CFSR) will be also discussed. Fig 1: Composite of the tangential wind speed at 925 hPa for 34 polar lows observed in the Norwegian sea between 2008-2010 as represented by the ERA-Interim reanalysis (left) and by the ECMWF Operational analysis (right). Positive values indicate cyclonic circulation. The composite is centered on the polar low vorticity maxima and it is presented for a radial cap of 5 degrees of radius on the sphere (~550Km).

Somatostatin: An endogenous antiepileptic

PubMed Central

Qiu, Cuie

2008-01-01

The neuropeptide somatostatin is highly expressed in brain regions associated with seizures. In hippocampus, SST expression and release is regulated by seizures, and SST-containing neurons within the hilus of the dentate gyrus are sensitive to seizure-induced death. In vivo and in vitro studies suggest that the loss of SST function in the dentate could contribute to epileptogenesis and seizure susceptibility. SST also has inhibitory actions in the CA1 and CA3 hippocampus, indicating this peptide is an important homeostatic regulator throughout the hippocampus. In vivo studies show SST has robust antiepileptic properties, with the major site of action being hippocampus. In rodents, somatostatin receptor subtype 2 (SST2) and SST4 appear to mediate the majority of the antiepileptic actions of SST, with SST2 predominate in rat and SST4 in mouse. Thus SST receptors may be appropriate targets for new antiepileptic drugs, although validation in human tissue is lacking. PMID:18221832

Understanding the tropical cloud feedback from an analysis of the circulation and stability regimes simulated from an upgraded multiscale modeling framework

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xu, Kuan-Man; Cheng, Anning

As revealed from studies using conventional general circulation models (GCMs), the thermodynamic contribution to the tropical cloud feedback dominates the dynamic contribution, but these models have difficulty in simulating the subsidence regimes in the tropics. In this study, we analyze the tropical cloud feedback from a 2 K sea surface temperature (SST) perturbation experiment performed with a multiscale modeling framework (MMF). The MMF explicitly represents cloud processes using 2-D cloud-resolving models with an advanced higher-order turbulence closure in each atmospheric column of the host GCM. We sort the monthly mean cloud properties and cloud radiative effects according to circulation andmore » stability regimes. Here, we find that the regime-sorted dynamic changes dominate the thermodynamic changes in terms of the absolute magnitude. The dynamic changes in the weak subsidence regimes exhibit strong negative cloud feedback due to increases in shallow cumulus and deep clouds while those in strongly convective and moderate-to-strong subsidence regimes have opposite signs, resulting in a small contribution to cloud feedback. On the other hand, the thermodynamic changes are large due to decreases in stratocumulus clouds in the moderate-to-strong subsidence regimes with small opposite changes in the weak subsidence and strongly convective regimes, resulting in a relatively large contribution to positive cloud feedback. The dynamic and thermodynamic changes contribute equally to positive cloud feedback and are relatively insensitive to stability in the moderate-to-strong subsidence regimes. But they are sensitive to stability changes from the SST increase in convective and weak subsidence regimes. Lastly, these results have implications for interpreting cloud feedback mechanisms.« less

Understanding the tropical cloud feedback from an analysis of the circulation and stability regimes simulated from an upgraded multiscale modeling framework

DOE PAGES

Xu, Kuan-Man; Cheng, Anning

2016-11-15

As revealed from studies using conventional general circulation models (GCMs), the thermodynamic contribution to the tropical cloud feedback dominates the dynamic contribution, but these models have difficulty in simulating the subsidence regimes in the tropics. In this study, we analyze the tropical cloud feedback from a 2 K sea surface temperature (SST) perturbation experiment performed with a multiscale modeling framework (MMF). The MMF explicitly represents cloud processes using 2-D cloud-resolving models with an advanced higher-order turbulence closure in each atmospheric column of the host GCM. We sort the monthly mean cloud properties and cloud radiative effects according to circulation andmore » stability regimes. Here, we find that the regime-sorted dynamic changes dominate the thermodynamic changes in terms of the absolute magnitude. The dynamic changes in the weak subsidence regimes exhibit strong negative cloud feedback due to increases in shallow cumulus and deep clouds while those in strongly convective and moderate-to-strong subsidence regimes have opposite signs, resulting in a small contribution to cloud feedback. On the other hand, the thermodynamic changes are large due to decreases in stratocumulus clouds in the moderate-to-strong subsidence regimes with small opposite changes in the weak subsidence and strongly convective regimes, resulting in a relatively large contribution to positive cloud feedback. The dynamic and thermodynamic changes contribute equally to positive cloud feedback and are relatively insensitive to stability in the moderate-to-strong subsidence regimes. But they are sensitive to stability changes from the SST increase in convective and weak subsidence regimes. Lastly, these results have implications for interpreting cloud feedback mechanisms.« less

Seasonal ENSO phase locking in the Kiel Climate Model: The importance of the equatorial cold sea surface temperature bias

NASA Astrophysics Data System (ADS)

Wengel, C.; Latif, M.; Park, W.; Harlaß, J.; Bayr, T.

2018-02-01

The El Niño/Southern Oscillation (ENSO) is characterized by a seasonal phase locking, with strongest eastern and central equatorial Pacific sea surface temperature (SST) anomalies during boreal winter and weakest SST anomalies during boreal spring. In this study, key feedbacks controlling seasonal ENSO phase locking in the Kiel Climate Model (KCM) are identified by employing Bjerknes index stability analysis. A large ensemble of simulations with the KCM is analyzed, where the individual runs differ in either the number of vertical atmospheric levels or coefficients used in selected atmospheric parameterizations. All integrations use the identical ocean model. The ensemble-mean features realistic seasonal ENSO phase locking. ENSO phase locking is very sensitive to changes in the mean-state realized by the modifications described above. An excessive equatorial cold tongue leads to weak phase locking by reducing the Ekman feedback and thermocline feedback in late boreal fall and early boreal winter. Seasonal ENSO phase locking also is sensitive to the shortwave feedback as part of the thermal damping in early boreal spring, which strongly depends on eastern and central equatorial Pacific SST. The results obtained from the KCM are consistent with those from models participating in the Coupled Model Intercomparison Project phase 5 (CMIP5).

Indonesia sea surface temperature from TRMM Microwave Imaging (TMI) sensor

NASA Astrophysics Data System (ADS)

Marini, Y.; Setiawan, K. T.

2018-05-01

We analysis the Tropical Rainfall Measuring Mission's (TRMM) Microwave Imager (TMI) data to monitor the sea surface temperature (SST) of Indonesia waters for a decade of 2005-2014. The TMI SST data shows the seasonal and interannual SST in Indonesian waters. In general, the SST average was highest in March-May period with SST average was 29.4°C, and the lowest was in June – August period with the SST average was 28.5°C. The monthly SST average fluctuation of Indonesian waters for 10 years tends to increase. The lowest SST average of Indonesia occurred in August 2006 with the SST average was 27.6° C, while the maximum occurred in May 2014 with the monthly SST average temperature was 29.9 ° C.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chan, R.K.; Otte, C.A.

Eight independently isolated mutants which are supersensitive (Sst/sup -/) to the G1 arrest induced by the tridecapeptide pheromone ..cap alpha.. factor were identified by screening mutagenized Saccharomyces cerevisiae MATa cells on solid medium for increased growth inhibition by ..cap alpha.. factor. These mutants carries lesions in two complementation groups, sst1 and sst2. Mutations at the sst1 locus were mating type specific: MATa sst1 cells were supersensitive to ..cap alpha.. factor, but MAT..cap alpha.. sst1 cells were not supersensitive to a factor. In contrast, mutations at the sst2 locus conferred supersensitivity to the pheromones of the opposite mating type on bothmore » MATa and MAT..cap alpha.. cells. Even in the absence of added ..cap alpha.. pheromone, about 10% of the cells in exponentially growing cultures of MATa strains carrying any of three different alleles of sst2 (including the ochre mutation sst2-4) had the aberrant morphology (''shmoo'' shape) that normally develops only after MATa cells are exposed to ..cap alpha.. factor. This ''self-shmooing'' phenotype was genetically linked to the sst2 mutations, although the leakiest allele isolated (sst2-3) did not display this characteristic. Normal MATa/MAT..cap alpha.. diploids do not respond to pheromones; diploids homozygous for an sst2 mutation (MATa/MAT..cap alpha.. sst2-1/sst2-1) were still insensitive to ..cap alpha.. factor. The sst1 gene was mapped to within 6.9 centimorgans of his6 on chromosome IX. The sst2 gene was unlinked to sst1, was not centromere linked, and was shown to be neither linked nor centromere distal to MAT on the right arm of chromosome III.« less

Endothelin-converting enzyme-1 degrades internalized somatostatin-14.

PubMed

Roosterman, Dirk; Kempkes, Cordula; Cottrell, Graeme S; Padilla, Benjamin E; Bunnett, Nigel W; Turck, Christoph W; Steinhoff, Martin

2008-05-01

Agonist-induced internalization of somatostatin receptors (ssts) determines subsequent cellular responsiveness to peptide agonists and influences sst receptor scintigraphy. To investigate sst2A trafficking, rat sst2A tagged with epitope was expressed in human embryonic kidney cells and tracked by antibody labeling. Confocal microscopical analysis revealed that stimulation with sst and octreotide induced internalization of sst2A. Internalized sst2A remained sequestrated within early endosomes, and 60 min after stimulation, internalized sst2A still colocalized with beta-arrestin1-enhanced green fluorescence protein (EGFP), endothelin-converting enzyme-1 (ECE-1), and rab5a. Internalized (125)I-Tyr(11)-SST-14 was rapidly hydrolyzed by endosomal endopeptidases, with radioactive metabolites being released from the cell. Internalized (125)I-Tyr(1)-octreotide accumulated as an intact peptide and was released from the cell as an intact peptide ligand. We have identified ECE-1 as one of the endopeptidases responsible for inactivation of internalized SST-14. ECE-1-mediated cleavage of SST-14 was inhibited by the specific ECE-1 inhibitor, SM-19712, and by preventing acidification of endosomes using bafilomycin A(1). ECE-1 cleaved SST-14 but not octreotide in an acidic environment. The metallopeptidases angiotensin-1 converting enzyme and ECE-2 did not hydrolyze SST-14 or octreotide. Our results show for the first time that stimulation with SST-14 and octreotide induced sequestration of sst2A into early endosomes and that endocytosed SST-14 is degraded by endopeptidases located in early endosomes. Furthermore, octreotide was not degraded by endosomal peptidases and was released as an intact peptide. This mechanism may explain functional differences between octreotide and SST-14 after sst2A stimulation. Moreover, further investigation of endopeptidase-regulated trafficking of neuropeptides may result in novel concepts of neuropeptide receptor inactivation in cancer diagnosis.

Sensitive study of the climatological SST by using ATSR global SST data sets

NASA Astrophysics Data System (ADS)

Xue, Yong; Lawrence, Sean P.; Llewellyn-Jones, David T.

1995-12-01

Climatological sea surface temperature (SST) is an initial step for global climate processing monitoring. A comparison has been made by using Oberhuber's SST data set and two years monthly averaged SST from ATSR thermal band data to force the OGCM. In the eastern Pacific Ocean, these make only a small difference to model SST. In the western Pacific Ocean, the use of Oberhuber's data set gives higher climatological SST than that using ATSR data. The SSTs were also simulated for 1992 using climatological SSTs from two years monthly averaged ATSR data and Oberhuber data. The forcing with SST from ATSR data was found to give better SST simulation than that from Oberhuber's data. Our study has confirmed that ATSR can provide accurate monthly averaged global SST for global climate processing monitoring.

Last Millennium ENSO-Mean State Interactions in the Tropical Pacific

NASA Astrophysics Data System (ADS)

Wyman, D. A.; Conroy, J. L.; Karamperidou, C.

2017-12-01

The nature and degree of interaction between the mean state of the tropical Pacific and ENSO remains an open question. Here we use high temporal resolution, tropical Pacific sea surface temperature (SST) records from the last millennium to investigate the relationship between ENSO and the tropical Pacific zonal sea surface temperature gradient (hereafter dSST). A dSST time series was created by standardizing, interpolating, and compositing 7 SST records from the western and 3 SST records from the eastern tropical Pacific. Propagating the age uncertainty of each of these records was accomplished through a Monte Carlo Empirical Orthogonal Function analysis. We find last millennium dSST is strong from 700 to 1300 CE, begins to weaken at approximately 1300 CE, and decreases more rapidly at 1700 CE. dSST was compared to 14 different ENSO reconstructions, independent of the records used to create dSST, to assess the nature of the ENSO-mean state relationship. dSST correlations with 50-year standard deviations of ENSO reconstructions are consistently negative, suggesting that more frequent, strong El Niño events on this timescale reduces dSST. To further assess the strength and direction of the ENSO-dSST relationship, moving 100-year standard deviations of ENSO reconstructions were compared to moving 100-year averages of dSST using Cohen's Kappa statistic, which measures categorical agreement. The Li et al. (2011) and Li et al. (2013) Nino 3.4 ENSO reconstructions had the highest agreement with dSST (k=0.80 and 0.70, respectively), with greater ENSO standard deviation coincident with periods of weak dSST. Other ENSO reconstructions showed weaker agreement with dSST, which may be partly due to low sample size. The consistent directional agreement of dSST with ENSO, coupled with the inability of strong ENSO events to develop under a weak SST gradient, suggests periods of more frequent strong El Niño events reduced tropical Pacific dSST on centennial timescales over the last millennium.

A dynamical stabilizer in the climate system: a mechanism suggested by a simple model

NASA Astrophysics Data System (ADS)

Bates, J. R.

1999-05-01

A simple zonally averaged hemispheric model of the climate system is constructed, based on energy equations for two ocean basins separated at 30° latitude with the surface fluxes calculated explicitly. A combination of empirical input and theoretical calculation is used to determine an annual mean equilibrium climate for the model and to study its stability with respect to small perturbations. The insolation, the mean albedos and the equilibrium temperatures for the two model zones are prescribed from observation. The principal agent of interaction between the zones is the vertically integrated poleward transport of atmospheric angular momentum across their common boundary. This is parameterized using an empirical formula derived from a multiyear atmospheric data set. The surface winds are derived from the angular momentum transport assuming the atmosphere to be in a state of dynamic balance on the climatic timescales of interest. A further assumption that the air sea temperature difference and low level relative humidity remain fixed at their mean observed values then allows the surface fluxes of latent and sensible heat to be calculated. Results from a radiative model, which show a positive lower tropospheric water vapour/infrared radiative feedback on SST perturbations in both zones, are used to calculate the net upward infrared radiative fluxes at the surface. In the model's equilibrium climate, the principal processes balancing the solar radiation absorbed at the surface are evaporation in the tropical zone and net infrared radiation in the extratropical zone. The stability of small perturbations about the equilibrium is studied using a linearized form of the ocean energy equations. Ice-albedo and cloud feedbacks are omitted and attention is focussed on the competing effects of the water vapour/infrared radiative feedback and the turbulent surface flux and oceanic heat transport feedbacks associated with the angular momentum cycle. The perturbation equations involve inter-zone coupling and have coefficients dependent on the values of the equilibrium fluxes and the sensitivity of the angular momentum transport. Analytical solutions for the perturbations are obtained. These provide criteria for the stability of the equilibrium climate. If the evaporative feedback on SST perturbations is omitted, the equilibrium climate is unstable due to the influence of the water vapour/infrared radiative feedback, which dominates over the effects of the sensible heat and ocean heat transport feedbacks. The inclusion of evaporation gives a negative feedback which is of sufficient strength to stabilize the system. The stabilizing mechanism involves wind and humidity factors in the evaporative fluxes that are of comparable magnitude. Both factors involve the angular momentum transport. In including angular momentum and calculating the surface fluxes explicitly, the model presented here differs from the many simple climate models based on the Budyko Sellers formulation. In that formulation, an atmospheric energy balance equation is used to eliminate surface fluxes in favour of top-of-the-atmosphere radiative fluxes and meridional atmospheric energy transports. In the resulting models, infrared radiation appears as a stabilizing influence on SST perturbations and the dynamical stabilizing mechanism found here cannot be identified.

The Relationships between Tropical Pacific and Atlantic SST and Northeast Brazil Monthly Precipitation.

NASA Astrophysics Data System (ADS)

Bertacchi Uvo, Cintia; Repelli, Carlos A.; Zebiak, Stephen E.; Kushnir, Yochanan

1998-04-01

The monthly patterns of northeast Brazil (NEB) precipitation are analyzed in relation to sea surface temperature (SST) in the tropical Pacific and Atlantic Oceans, using singular value decomposition. It is found that the relationships between precipitation and SST in both basins vary considerably throughout the rainy season (February-May). In January, equatorial Pacific SST is weakly correlated with precipitation in small areas of southern NEB, but Atlantic SST shows no significant correlation with regional precipitation. In February, Pacific SST is not well related to precipitation, but south equatorial Atlantic SST is positively correlated with precipitation over the northern Nordeste, the latter most likely reflecting an anomalously early (or late) southward migration of the ITCZ precipitation zone. During March, equatorial Pacific SST is negatively correlated with Nordeste precipitation, but no consistent relationship between precipitation and Atlantic SST is found. Atlantic SST-precipitation correlations for April and May are the strongest found among all months or either ocean. Precipitation in the Nordeste is positively correlated with SST in the south tropical Atlantic and negatively correlated with SST in the north tropical Atlantic. These relationships are strong enough to determine the structure of the seasonal mean SST-precipitation correlations, even though the corresponding patterns for the earlier months of the season are quite different. Pacific SST-precipitation correlations for April and May are similar to those for March. Extreme wet (dry) years for the Nordeste occur when both Pacific and Atlantic SST patterns for April and May occur simultaneously. A separate analysis reinforces previous findings in showing that SST in the tropical Pacific and the northern tropical Atlantic are positively correlated and that tropical Pacific-south Atlantic correlations are negligible.Time-lagged analyses show the potential for forecasting either seasonal mean or monthly precipitation patterns with some degree of skill. In some instances, individual monthly mean SST versus seasonal mean (February-May) precipitation relationships differ considerably from the corresponding monthly SST versus monthly precipitation relationships. It is argued that the seasonal mean relationships result from the relatively strong monthly relationships toward the end of the season, combined with the considerable persistence of SST in both oceans.

Differential somatostatin, CXCR4 chemokine and endothelin A receptor expression in WHO grade I-IV astrocytic brain tumors.

PubMed

Lange, Franziska; Kaemmerer, Daniel; Behnke-Mursch, Julianne; Brück, Wolfgang; Schulz, Stefan; Lupp, Amelie

2018-04-25

Glioblastomas represent the most common primary malignant tumor of the nervous system and the most frequent type of astrocytic tumors. Despite improved therapeutic options, prognosis has remained exceptionally poor over the last two decades. Therefore, new treatment approaches are urgently needed. An overexpression of somatostatin (SST) as well as chemokine CXCR4 and endothelin A (ETA) receptors has been shown for many types of cancer. Respective expression data for astrocytic brain tumors, however, are scarce and contradictory. SST subtype, CXCR4 and ETA expression was comparatively evaluated in a total of 57 grade I-IV astrocytic tumor samples by immunohistochemistry using well-characterized monoclonal antibodies. Overall, receptor expression on the tumor cells was only very low. SST5 was the most prominently expressed receptor, followed by SST3, ETA, SST2 and CXCR4. In contrast, tumor capillaries displayed strong SST2, SST3, SST5, CXCR4 and ETA expression. Presence of SST5, CXCR4 and ETA on tumor cells and of SST3, CXCR4 and ETA on microvessels gradually increased from grade II to grade IV tumors. Ki-67 values correlated significantly with CXCR4 expression on tumor cells and with vascular SST3, CXCR4 or ETA positivity. SST5 or CXCR4 positivity of tumor cells and vascular SST3 or CXCR4 expression negatively correlated with patient outcome. Though having some prognostic value, SST, CXCR4 or ETA expression on astrocytic tumor cells is clearly of no therapeutic relevance. Indirect targeting of these highly vascularized tumors via SST3, SST5, CXCR4 or ETA on the microvessels, in contrast, may represent a promising additional therapeutic strategy.

Protective role of somatostatin receptor 2 against retinal degeneration in response to hypoxia.

PubMed

Dal Monte, Massimo; Latina, Valentina; Cupisti, Elena; Bagnoli, Paola

2012-05-01

In mouse retinal explants, octreotide, a somatostatin [somatotropin release-inhibiting factor (SRIF)] receptor 2 (sst(2)) agonist, prevents the hypoxia-induced vascular endothelial growth factor upregulation. In mice with oxygen-induced retinopathy (OIR), a model of retinopathy of prematurity, either sst(2) overexpression or octreotide have been found to limit hypoxia-induced angiogenic processes. Here, we investigated whether sst(2) influences retinal degeneration in response to hypoxia in wild-type (WT), sst(1)- and sst(2)-knockout (KO) mice. In retinal explants, we determined the role of sst(2) on apoptotic signals. In control condition, caspase-3 activity and the Bax/Bcl-2 ratio were lower in sst(1)-KO than in WT, but higher in sst(2)-KO than in WT retinas. In all strains, a comparable increase in caspase-3 activity and the Bax/Bcl-2 ratio was observed after hypoxia. The hypoxia-induced increase in apoptotic signals was recovered by octreotide in both WT and sst(1)-KO retinas. To investigate the role of sst(2) on retinal function, we recorded electroretinogram (ERG) in response to light flashes in OIR mice. ERG responses did not differ between WT and KO mice with the exception of oscillatory potentials (OPs) which, in sst(1)-KO mice, displayed much larger amplitude. In all strains, hypoxia drastically reduced a-, b-waves and OPs. In both WT and sst(1)-KO mice, octreotide recovered a- and b-waves, but did not recover OPs in sst(1)-KO mice. Neither apoptotic signals nor ERG was affected by octreotide in sst(2)-KO mice. These results show that sst(2) may protect retinal cells from hypoxia, thus implementing the background to establish potential pharmacological targets based on sst(2) pharmacology.

Warm layer and cool skin corrections for bulk water temperature measurements for air-sea interaction studies

NASA Astrophysics Data System (ADS)

Alappattu, Denny P.; Wang, Qing; Yamaguchi, Ryan; Lind, Richard J.; Reynolds, Mike; Christman, Adam J.

2017-08-01

The sea surface temperature (SST) relevant to air-sea interaction studies is the temperature immediately adjacent to the air, referred to as skin SST. Generally, SST measurements from ships and buoys are taken at depths varies from several centimeters to 5 m below the surface. These measurements, known as bulk SST, can differ from skin SST up to O(1°C). Shipboard bulk and skin SST measurements were made during the Coupled Air-Sea Processes and Electromagnetic ducting Research east coast field campaign (CASPER-East). An Infrared SST Autonomous Radiometer (ISAR) recorded skin SST, while R/V Sharp's Surface Mapping System (SMS) provided bulk SST from 1 m water depth. Since the ISAR is sensitive to sea spray and rain, missing skin SST data occurred in these conditions. However, SMS measurement is less affected by adverse weather and provided continuous bulk SST measurements. It is desirable to correct the bulk SST to obtain a good representation of the skin SST, which is the objective of this research. Bulk-skin SST difference has been examined with respect to meteorological factors associated with cool skin and diurnal warm layers. Strong influences of wind speed, diurnal effects, and net longwave radiation flux on temperature difference are noticed. A three-step scheme is established to correct for wind effect, diurnal variability, and then for dependency on net longwave radiation flux. Scheme is tested and compared to existing correction schemes. This method is able to effectively compensate for multiple factors acting to modify bulk SST measurements over the range of conditions experienced during CASPER-East.

The Aqua-planet Experiment (APE): Response to Changed Meridional SST Profile

NASA Technical Reports Server (NTRS)

Williamson, David L.; Blackburn, Michael; Nakajima, Kensuke; Ohfuchi, Wataru; Takahashi, Yoshiyuki O.; Hayashi, Yoshi-Yuki; Nakamura, Hisashi; Ishiwatari, Masaki; Mcgregor, John L.; Borth, Hartmut;

Mechanisms of northeastern Brazil rainfall anomalies due to Southern Tropical Atlantic variability

NASA Astrophysics Data System (ADS)

Neelin, J.; Su, H.

2004-05-01

Observational studies have shown that the rainfall anomalies in eastern equatorial South America, including Nordeste Brazil, have a positive correlation with tropical southern Atlantic sea surface temperature (SST) anomalies. Such relationships are reproduced in model simulations with the quasi-equilibrium tropical circulation model (QTCM), which includes a simple land model. A suite of model ensemble experiments is analysed using observed SST over the tropical oceans, the tropical Atlantic and the tropical southern Atlantic (30S-0), respectively (with climatological SST in the remainder of the oceans). Warm tropical south Atlantic SST anomalies yield positive precipitation anomalies over the Nordeste and the southern edge of the Atlantic marine intertropical convergence zone (ITCZ). Mechanisms associated with moisture variations are responsible for the land precipitation changes. Increases in moisture over the Atlantic cause positive anomalies in moisture advection, spreading increased moisture downwind. Where the basic state is far from the convective stability threshold, moisture changes have little effect, but the margins of the climatological convection zone are affected. The increased moisture supply due to advection is enhanced by increases in low-level convergence required by moist static energy balances. The moisture convergence term is several times larger, but experiments altering the moisture advection confirm that the feedback is initiated by wind acting on moisture gradient. This mechanism has several features in common with the recently published "upped-ante" mechanism for El Nino impacts on this region. In that case, the moisture gradient is initiated by warm free tropospheric temperature anomalies increasing the typical value of low-level moisture required to sustain convection in the convection zones. Both mechanisms suggest the usefulness of coordinating ocean and land in situ observations of boundary layer moisture.

Suitability of satellite derived and gridded sea surface temperature data sets for calibrating high-resolution marine proxy records

NASA Astrophysics Data System (ADS)

Ouellette, G., Jr.; DeLong, K. L.

2016-02-01

High-resolution proxy records of sea surface temperature (SST) are increasingly being produced using trace element and isotope variability within the skeletal materials of marine organisms such as corals, mollusks, sclerosponges, and coralline algae. Translating the geochemical variations within these organisms into records of SST requires calibration with SST observations using linear regression methods, preferably with in situ SST records that span several years. However, locations with such records are sparse; therefore, calibration is often accomplished using gridded SST data products such as the Hadley Center's HADSST (5º) and interpolated HADISST (1º) data sets, NOAA's extended reconstructed SST data set (ERSST; 2º), optimum interpolation SST (OISST; 1º), and Kaplan SST data sets (5º). From these data products, the SST used for proxy calibration is obtained for a single grid cell that includes the proxy's study site. The gridded data sets are based on the International Comprehensive Ocean-Atmosphere Data Set (ICOADS) and each uses different methods of interpolation to produce the globally and temporally complete data products except for HadSST, which is not interpolated but quality controlled. This study compares SST for a single site from these gridded data products with a high-resolution satellite-based SST data set from NOAA (Pathfinder; 4 km) with in situ SST data and coral Sr/Ca variability for our study site in Haiti to assess differences between these SST records with a focus on seasonal variability. Our results indicate substantial differences in the seasonal variability captured for the same site among these data sets on the order of 1-3°C. This analysis suggests that of the data products, high-resolution satellite SST best captured seasonal variability at the study site. Unfortunately, satellite SST records are limited to the past few decades. If satellite SST are to be used to calibrate proxy records, collecting modern, living samples is desirable.

Endothelin-Converting Enzyme-1 Degrades Internalized Somatostatin-14

PubMed Central

Roosterman, Dirk; Kempkes, Cordula; Cottrell, Graeme S.; Padilla, Benjamin E.; Bunnett, Nigel W.; Turck, Christoph W.; Steinhoff, Martin

2008-01-01

Agonist-induced internalization of somatostatin receptors (ssts) determines subsequent cellular responsiveness to peptide agonists and influences sst receptor scintigraphy. To investigate sst2A trafficking, rat sst2A tagged with epitope was expressed in human embryonic kidney cells and tracked by antibody labeling. Confocal microscopical analysis revealed that stimulation with sst and octreotide induced internalization of sst2A. Internalized sst2A remained sequestrated within early endosomes, and 60 min after stimulation, internalized sst2A still colocalized with β-arrestin1-enhanced green fluorescence protein (EGFP), endothelin-converting enzyme-1 (ECE-1), and rab5a. Internalized 125I-Tyr11-SST-14 was rapidly hydrolyzed by endosomal endopeptidases, with radioactive metabolites being released from the cell. Internalized 125I-Tyr1-octreotide accumulated as an intact peptide and was released from the cell as an intact peptide ligand. We have identified ECE-1 as one of the endopeptidases responsible for inactivation of internalized SST-14. ECE-1-mediated cleavage of SST-14 was inhibited by the specific ECE-1 inhibitor, SM-19712, and by preventing acidification of endosomes using bafilomycin A1. ECE-1 cleaved SST-14 but not octreotide in an acidic environment. The metallopeptidases angiotensin-1 converting enzyme and ECE-2 did not hydrolyze SST-14 or octreotide. Our results show for the first time that stimulation with SST-14 and octreotide induced sequestration of sst2A into early endosomes and that endocytosed SST-14 is degraded by endopeptidases located in early endosomes. Furthermore, octreotide was not degraded by endosomal peptidases and was released as an intact peptide. This mechanism may explain functional differences between octreotide and SST-14 after sst2A stimulation. Moreover, further investigation of endopeptidase-regulated trafficking of neuropeptides may result in novel concepts of neuropeptide receptor inactivation in cancer diagnosis. PMID:18276747

Roles of Hippocampal Somatostatin Receptor Subtypes in Stress Response and Emotionality.

PubMed

Prévôt, Thomas D; Gastambide, François; Viollet, Cécile; Henkous, Nadia; Martel, Guillaume; Epelbaum, Jacques; Béracochéa, Daniel; Guillou, Jean-Louis

2017-07-01

Altered brain somatostatin functions recently appeared as key elements for the pathogenesis of stress-related neuropsychiatric disorders. The hippocampus exerts an inhibitory feedback on stress but the mechanisms involved remain unclear. We investigated herein the role of hippocampal somatostatin receptor subtypes in both stress response and behavioral emotionality using C57BL/6, wild type and sst 2 or sst 4 knockout mice. Inhibitory effects of hippocampal infusions of somatostatin agonists on stress-induced hypothalamo-pituitary-adrenal axis (HPA) activity were tested by monitoring peripheral blood and local hippocampus corticosterone levels, the latter by using microdialysis. Anxiolytic and antidepressant-like effects were determined in the elevated-plus maze, open field, forced swimming, and stress-sensitive beam walking tests. Hippocampal injections of somatostatin analogs and sst 2 or sst 4, but not sst 1 or sst 3 receptor agonists produced rapid and sustained inhibition of HPA axis. sst 2 agonists selectively produced anxiolytic-like behaviors whereas both sst 2 and sst 4 agonists had antidepressant-like effects. Consistent with these findings, high corticosterone levels and anxiety were found in sst 2 KO mice and depressive-like behaviors observed in both sst 2 KO and sst 4 KO strains. Both hippocampal sst 2 and sst 4 receptors selectively inhibit stress-induced HPA axis activation but mediate anxiolytic and antidepressive effects through distinct mechanisms. Such results are to be accounted for in development of pathway-specific somatostatin receptor agents in the treatment of hypercortisolism (Cushing's disease) and stress-related neuropsychiatric disorders.

Merging of multi-temporal SST data at South China Sea

NASA Astrophysics Data System (ADS)

Ng, H. G.; MatJafri, M. Z.; Abdullah, K.; Lim, H. S.

2008-10-01

The sea surface temperature (SST) mapping could be performed with a wide spatial and temporal extent in a reasonable time limit. The space-borne sensor of AVHRR was widely used for the purpose. However, the current SST retrieval techniques for infrared channels were limited only for the cloud-free area, because the electromagnetic waves in the infrared wavelengths could not penetrate the cloud. Therefore, the SST availability was low for the single image. To overcome this problem, we studied to produce the composite of three day's SST map. The diurnal changes of SST data are quite stable through a short period of time if no abrupt natural disaster occurrence. Therefore, the SST data of three consecutive days with nearly coincident daily time were merged in order to create a three day's composite SST data. The composite image could increase the SST availability. In this study, we acquired the level 1b AVHRR (Advanced Very High Resolution Radiometer) images from Malaysia Center of Remote Sensing (MACRES). The images were first preprocessed and the cloud and land areas were masked. We made some modifications on the technique of obtaining the threshold value for cloud masking. The SST was estimated by using the day split MCSST algorithm. The cloud free water pixels availability were computed and compared. The mean of SST for three day's composite data were calculated and a SST map was generated. The cloud free water pixels availability were computed and compared. The SST data availability was increased by merging the SST data.

Octreotide and pasireotide (dis)similarly inhibit pituitary tumor cells in vitro.

PubMed

Ibáñez-Costa, Alejandro; Rivero-Cortés, Esther; Vázquez-Borrego, Mari C; Gahete, Manuel D; Jiménez-Reina, Luis; Venegas-Moreno, Eva; de la Riva, Andrés; Arráez, Miguel Ángel; González-Molero, Inmaculada; Schmid, Herbert A; Maraver-Selfa, Silvia; Gavilán-Villarejo, Inmaculada; García-Arnés, Juan Antonio; Japón, Miguel A; Soto-Moreno, Alfonso; Gálvez, María A; Luque, Raúl M; Castaño, Justo P

2016-11-01

Somatostatin analogs (SSA) are the mainstay of pharmacological treatment for pituitary adenomas. However, some patients escape from therapy with octreotide, a somatostatin receptor 2 (sst2)-preferring SSA, and pasireotide, a novel multi-sst-preferring SSA, may help to overcome this problem. It has been proposed that correspondence between sst1-sst5 expression pattern and SSA-binding profile could predict patient's response. To explore the cellular/molecular features associated with octreotide/pasireotide response, we performed a parallel comparison of their in vitro effects, evaluating sst1-sst5 expression, intracellular Ca 2+ signaling ([Ca 2+ ] i ), hormone secretion and cell viability, in a series of 85 pituitary samples. Somatotropinomas expressed sst5>sst2, yet octreotide reduced [Ca 2+ ] i more efficiently than pasireotide, while both SSA similarly decreased growth hormone release/expression and viability. Corticotropinomas predominantly expressed sst5, but displayed limited response to pasireotide, while octreotide reduced functional endpoints. Non-functioning adenomas preferentially expressed sst3 but, surprisingly, both SSA increased cell viability. Prolactinomas mainly expressed sst1 but were virtually unresponsive to SSA. Finally, both SSA decreased [Ca 2+ ] i in normal pituitaries. In conclusion, both SSA act in vitro on pituitary adenomas exerting both similar and distinct effects; however, no evident correspondence was found with the sst1-sst5 profile. Thus, it seems plausible that additional factors, besides the simple abundance of a given sst, critically influence the SSA response. © 2016 Society for Endocrinology.

Global trends in significant wave height and marine wind speed from the ERA-20CM

NASA Astrophysics Data System (ADS)

Aarnes, Ole Johan; Breivik, Øyvind

2016-04-01

The ERA-20CM is one of the latest additions to the ERA-series produced at the European Center for Medium-Range Weather Forecasts (ECMWF). This 10 member ensemble is generated with a version of the Integrated Forecast System (IFS), a coupled atmosphere-wave model. The model integration is run as a AMIP (Atmospheric Model Intercomparison Project) constrained by CMIP5 recommended radiative forcing and different realizations of sea-surface temperature (SST) and sea-ice cover (SIC) prescribed by the HadISST2 (Met Office Hadley Center). While the ERA-20CM is unable to reproduce the actual synoptic conditions, it is designed to offer a realistic statistical representation of the past climate, spanning the period 1899-2010. In this study we investigate global trends in significant wave height and marine wind speed based on ERA-20CM, using monthly mean data, upper percentiles and monthly/annual maxima. The aim of the study is to assess the quality of the trends and how these estimates are affected by different SST and SIC. Global trends are compared against corresponding estimates obtained with ERA-Interim (1979-2009), but also crosschecked against ERA-20C - an ECMWF pilot reanalysis of the 20th-century, known to most trustworthy in the Northern Hemisphere extratropics. Over the period 1900-2009, the 10 member ensemble yields trends mainly within +/- 5% per century. However, significant trends of opposite signs are found locally. Certain areas, like the eastern equatorial Pacific, highly affected by the El Niño Southern Oscillation, show stronger trends. In general, trends based on statistical quantities further into the tail of the distribution are found less reliable.

Impact of Arctic sea-ice retreat on the recent change in cloud-base height during autumn

NASA Astrophysics Data System (ADS)

Sato, K.; Inoue, J.; Kodama, Y.; Overland, J. E.

2012-12-01

Cloud-base observations over the ice-free Chukchi and Beaufort Seas in autumn were conducted using a shipboard ceilometer and radiosondes during the 1999-2010 cruises of the Japanese R/V Mirai. To understand the recent change in cloud base height over the Arctic Ocean, these cloud-base height data were compared with the observation data under ice-covered situation during SHEBA (the Surface Heat Budget of the Arctic Ocean project in 1998). Our ice-free results showed a 30 % decrease (increase) in the frequency of low clouds with a ceiling below (above) 500 m. Temperature profiles revealed that the boundary layer was well developed over the ice-free ocean in the 2000s, whereas a stable layer dominated during the ice-covered period in 1998. The change in surface boundary conditions likely resulted in the difference in cloud-base height, although it had little impact on air temperatures in the mid- and upper troposphere. Data from the 2010 R/V Mirai cruise were investigated in detail in terms of air-sea temperature difference. This suggests that stratus cloud over the sea ice has been replaced as stratocumulus clouds with low cloud fraction due to the decrease in static stability induced by the sea-ice retreat. The relationship between cloud-base height and air-sea temperature difference (SST-Ts) was analyzed in detail using special section data during 2010 cruise data. Stratus clouds near the sea surface were predominant under a warm advection situation, whereas stratocumulus clouds with a cloud-free layer were significant under a cold advection situation. The threshold temperature difference between sea surface and air temperatures for distinguishing the dominant cloud types was 3 K. Anomalous upward turbulent heat fluxes associated with the sea-ice retreat have likely contributed to warming of the lower troposphere. Frequency distribution of the cloud-base height (km) detected by a ceilometer/lidar (black bars) and radiosondes (gray bars), and profiles of potential temperature (K) for (a) ice-free cases (R/V Mirai during September) and (b) ice-covered case (SHEBA during September 1998). (c) Vertical profiles of air temperature from 1000 hPa to 150 hPa (solid lines: observations north of 75°N, and dashed lines: the ERA-Interim reanalysis over 75-82.5°N, 150-170°W). Green, blue, and red lines denote profiles derived from observations by NP stations (the 1980s), SHEBA (1998), and the R/V Mirai (the 2000s), respectively. (d) Temperature trend calculated by the ERA-Interim reanalysis over the area.

A Regulation of Tropical Climate by Radiative Cooling as Simulated in a Cumulus Ensemble Model

NASA Technical Reports Server (NTRS)

Sui, Chung-Hsiung; Lau, K.-M.; Li, X.; Chou, M.-D.; Einaudi, Franco (Technical Monitor)

2000-01-01

Responses of tropical atmosphere to low-boundary forcing are investigated in a 2-D cumulus ensemble model (CEM) with an imposed warm-pool and cold-pool SST contrast (deltaSST). The domain-mean vertical motion is constrained to produce heat sink and moisture source as in the observed tropical climate. In a series of experiments, the warm pool SST is specified at different values while the cold pool SST is specified at 26 C. The strength of the circulation increases with increasing deltaSST until deltaSST reaches 3.5 C, and remains unchanged as deltaSST exceeds 3.5 C. The regulation of tropical convection by zonal SST gradient is constrained by the radiative cooling over the cold pool. For deltaSST less than 3.5 C, an enhanced subsidence warming is balanced by a reduced condensation heating over the cold pool. For deltaSST greater than 3.5 C, the subsidence regime expands over the entire cold pool where no condensation heating exist so that a further enhanced subsidence warming can no longer be sustained. The above regulation mechanism is also evident in the change of energy at the top of the atmosphere (TOA) that is dominated by cloud and water vapor greenhouse effect (c (sub LW)) and G (sub clear). The change in shortwave radiation at TOA is largely cancelled between the warm pool and cold pool, likely due to the same imposed vertical motion in our experiments. For deltaSST less than 3.5 C, an increase of deltaSST is associated with a large increase in c (sub Lw) due to increased total clouds in response to enhanced SST-induced circulation. For deltaSST greater than 3.5 C, clouds over the warm pool decrease with increasing SST, and the change in c (sub LW) is much smaller. In both dSST regimes, the change in CLW is larger than the change in G(sub clear) which is slightly negative. However, in the case of uniform warming (deltaSST=0), DeltaG(sub clear), is positive, approximately 5 W per square meters per degree change of SST.

CFS Forecast Verification

Science.gov Websites

history of Nino3.4 SST anomalies of individual forecasts Forecast anomalies Target season Nino SST Global SST Global Prec Global T2m US Prec US T2m US SM z200 NDJ 2004/2005 Nino SST Global SST Global Prec Global T2m US Prec US T2m US SM z200 DJF 2005 Nino SST Global SST Global Prec Global T2m US Prec US T2m

Evaluation of ERA-interim and MERRA Cloudiness in the Southern Oceans

NASA Technical Reports Server (NTRS)

Naud, Catherine M.; Booth, James F.; Del Genio, Anthony D.

2014-01-01

The Southern Ocean cloud cover modeled by the Interim ECMWF Re-Analysis (ERA-Interim) and Modern- Era Retrospective Analysis for Research and Applications (MERRA) reanalyses are compared against Moderate Resolution Imaging Spectroradiometer (MODIS) and Multiangle Imaging Spectroradiometer (MISR) observations. ERA-Interim monthly mean cloud amounts match the observations within 5%, while MERRA significantly underestimates the cloud amount. For a compositing analysis of clouds in warm season extratropical cyclones, both reanalyses show a low bias in cloud cover. They display a larger bias to the west of the cyclones in the region of subsidence behind the cold fronts. This low bias is larger for MERRA than for ERA-Interim. Both MODIS and MISR retrievals indicate that the clouds in this sector are at a low altitude, often composed of liquid, and of a broken nature. The combined CloudSat-Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations (CALIPSO) cloud profiles confirm these passive observations, but they also reveal that low-level clouds in other parts of the cyclones are also not properly represented in the reanalyses. The two reanalyses are in fairly good agreement for the dynamic and thermodynamic characteristics of the cyclones, suggesting that the cloud, convection, or boundary layer schemes are the problem instead. An examination of the lower-tropospheric stability distribution in the cyclones from both reanalyses suggests that the parameterization of shallow cumulus clouds may contribute in a large part to the problem. However, the differences in the cloud schemes and in particular in the precipitation processes, which may also contribute, cannot be excluded.

Differential plastic changes in synthesis and binding in the mouse somatostatin system after electroconvulsive stimulation.

PubMed

Olesen, Mikkel Vestergaard; Gøtzsche, Casper René; Christiansen, Søren Hofman; Woldbye, David Paul Drucker

2018-03-21

Electroconvulsive therapy (ECT) is regularly used to treat patients with severe major depression, but the mechanisms underlying the beneficial effects remain uncertain. Electroconvulsive stimulation (ECS) regulates diverse neurotransmitter systems and induces anticonvulsant effects, properties implicated in mediating therapeutic effects of ECT. Somatostatin (SST) is a candidate for mediating these effects because it is upregulated by ECS and exerts seizure-suppressant effects. However, little is known about how ECS might affect the SST receptor system. The present study examined effects of single and repeated ECS on the synthesis of SST receptors (SSTR1-4) and SST, and SST receptor binding ([125I]LTT-SST28) in mouse hippocampal regions and piriform/parietal cortices. A complex pattern of plastic changes was observed. In the dentate gyrus, SST and SSTR1 expression and the number of hilar SST immunoreactive cells were significantly increased at 1 week after repeated ECS while SSTR2 expression was downregulated by single ECS, and SSTR3 mRNA and SST binding were elevated 24 h after repeated ECS. In hippocampal CA1 and parietal/piriform cortices, we found elevated SST mRNA levels 1 week after repeated ECS and elevated SST binding after single ECS and 24 h after repeated ECS. In hippocampal CA3, repeated ECS increased SST expression 1 week after and SST binding 24 h after. In the parietal cortex, SSTR2 mRNA expression was downregulated after single ECS while SSTR4 mRNA expression was upregulated 24 h after repeated ECS. Considering the known anticonvulsant effects of SST, it is likely that these ECS-induced neuroplastic changes in the SST system could participate in modulating neuronal excitability and potentially contribute to therapeutic effects of ECT.

Somatostatin type-2 receptor activation inhibits glutamate release and prevents status epilepticus

PubMed Central

Kozhemyakin, Maxim; Rajasekaran, Karthik; Todorovic, Marko S.; Kowalski, Samuel L.; Balint, Corinne; Kapur, Jaideep

2013-01-01

Summary Newer therapies are needed for the treatment of status epilepticus (SE) refractory to benzodiazepines. Enhanced glutamatergic neurotransmission leads to SE, and AMPA receptors are modified during SE. Reducing glutamate release during SE is a potential approach to terminate SE. The neuropeptide somatostatin (SST) is proposed to diminish presynaptic glutamate release by activating SST type-2 receptors (SST2R). SST exerts an anticonvulsant action in some experimental models of seizures. Here, we investigated the mechanism of action of SST on excitatory synaptic transmission at the Schaffer collateral-CA1 synapses and the ability of SST to treat SE in rats using patch-clamp electrophysiology and video-EEG monitoring of seizures. SST reduced action potential-dependent EPSCs (sEPSCs) at Schaffer collateral-CA1 synapses at concentrations up to 1 μM; higher concentrations had no effect or increased the sEPSC frequency. SST also prevented paired-pulse facilitation of evoked EPSCs and did not alter action-potential-independent miniature EPSCs (mEPSCs). The effect of SST on EPSCs was inhibited by the SST2R antagonist cyanamid-154806 and was mimicked by the SST2R agonists, octreotide and lanreotide. Both SST and octreotide reduced the firing rate of CA1 pyramidal neurons. Intraventricular administration of SST, within a range of doses, either prevented or attenuated pilocarpine-induced SE or delayed the median time to the first grade 5 seizure by 11 min. Similarly, octreotide or lanreotide prevented or attenuated SE in more than 65% of animals. Compared to the pilocarpine model, octreotide was highly potent in preventing or attenuating continuous hippocampal stimulation-induced SE in all animals within 60 min of SE onset. Our results demonstrate that SST, through the activation of SST2Rs, diminishes presynaptic glutamate release and attenuates SE. PMID:23473742

Tropical warm pool rainfall variability and impact on upper ocean variability throughout the Madden-Julian oscillation

NASA Astrophysics Data System (ADS)

Thompson, Elizabeth J.

Heating and rain freshening often stabilize the upper tropical ocean, bringing the ocean mixed layer depth to the sea surface. Thin mixed layer depths concentrate subsequent fluxes of heat, momentum, and freshwater in a thin layer. Rapid heating and cooling of the tropical sea surface is important for controlling or triggering atmospheric convection. Ocean mixed layer depth and SST variability due to rainfall events have not been as comprehensively explored as the ocean's response to heating or momentum fluxes, but are very important to understand in the tropical warm pool where precipitation exceeds evaporation and many climate phenomena such as ENSO and the MJO (Madden Julian Oscillation) originate. The first part of the dissertation investigates tropical, oceanic convective and stratiform rainfall variability and determines how to most accurately estimate rainfall accumulation with radar from each rain type. The second, main part of the dissertation uses central Indian Ocean salinity and temperature microstructure measurements and surrounding radar-derived rainfall maps throughout two DYNAMO MJO events to determine the impact of precipitating systems on upper-ocean mixed layer depth and resulting SST variability. The ocean mixed layer was as shallow as 0-5 m during 528/1071 observation hours throughout 2 MJOs (54% of the data record). Out of 43 observation days, thirty-eight near-surface mixed layer depth events were attributed to freshwater stabilization, called rain-formed mixed layers (RFLs). Thirty other mixed layer stratification events were classified as diurnal warm layers (DWLs) due to stable temperature stratification by daytime heating. RFLs and DWLs were observed to interact in two ways: 1) RFLs fill preexisting DWLs and add to total near-surface mixed layer stratification, which occurred ten times; 2) RFLs last long enough to heat, creating a new DWL on top of the RFL, which happened nine times. These combination stratification events were responsible for the highest SST warming rates and some of the highest SSTs leading up to the most active precipitation and wind stage of the each MJO. DWLs without RFL interaction helped produce the highest SSTs in suppressed MJO conditions. As storm intensity, frequency, duration, and the ability of storms to maintain stratiform rain areas increased, RFLS became more common in the disturbed and active MJO phases. Along with the barrier layer, DWL and RFL stratification events helped suppress wind-mixing, cooling, and mixed layer deepening throughout the MJO. We hypothesize that both salinity and temperature stratification events, and their interactions, are important for controlling SST variability and therefore MJO initiation in the Indian Ocean. Most RFLs were caused by submesoscale and mesoscale convective systems with stratiform rain components and local rain accumulations above 10 mm but with winds mostly below 8 m s-1. We hypothesize that the stratiform rain components of storms helped stratify the ocean by providing weak but widespread, steady, long-lived freshwater fluxes. Although generally limited to rain rates ≤ 10 mm hr-1, it is demonstrated that stratiform rain can exert a strong buoyancy flux into the ocean, i.e. as high as maximum daytime solar heating. Storm morphology and the preexisting vertical structure of ocean stability were critical in determining ocean mixed layer depth variability in the presence of rain. Therefore, we suggest that high spatial and temporal resolution coupled ocean-atmosphere models that can parameterize or resolve storm morphology as well as ocean mixed layer and barrier layer evolution are needed to reproduce the diurnal and intraseasonal SST variability documented throughout the MJO.

Interbasin Differences in the Relationship between SST and Tropical Cyclone Intensification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Foltz, Gregory R.; Balaguru, Karthik; Hagos, Samson

Sea surface temperature (SST) is one of the most important parameters for tropical cyclone (TC) intensification. Here it is shown that the impact of SST on TC intensification varies considerably from basin to basin, with SST explaining less than 3% of the variance in TC intensification rates in the Atlantic, 10% in the western North Pacific, and 17% in the eastern Pacific. Two main factors are shown to be responsible for these inter-basin differences. First, variability of SST along TCs’ tracks is considerably lower in the Atlantic. This is due to smaller horizontal SST gradients in the Atlantic compared tomore » the eastern Pacific and stronger damping of pre-storm SST’s contribution to TC intensification by the storm-induced cold SST wake in the Atlantic. The damping occurs because SST tends to vary in phase with TC- induced SST cooling: in the Gulf of Mexico and northwestern basin where SSTs are highest, TCs’ translation speeds are lowest and therefore their cold wakes are strongest. In addition to this SST effect, a second factor is that SST tends to vary out of phase with vertical wind shear and outflow temperature in the western Pacific, with high SST associated with weak wind shear and a cold upper troposphere. This strengthens the relationship between SST and TC intensification more in the western Pacific than in the eastern Pacific or Atlantic. Combined, these factors explain why pre-storm SST is such a poor predictor of TC intensification in the Atlantic compared to the eastern and western North Pacific.« less

Central administration of pansomatostatin agonist ODT8-SST prevents abdominal surgery-induced inhibition of circulating ghrelin, food intake and gastric emptying in rats

PubMed Central

STENGEL, A.; GOEBEL-STENGEL, M.; WANG, L.; LUCKEY, A.; HU, E.; RIVIER, J.; TACHÉ, Y.

2011-01-01

Background Activation of brain somatostatin receptors (sst1-5) with the stable pan-sst1-5 somatostatin agonist, ODT8-SST blocks acute stress and central corticotropin-releasing factor (CRF)-mediated activation of endocrine adrenal sympathetic responses. Brain CRF signaling is involved in delaying gastric emptying (GE) immediately post surgery. We investigated whether activation of brain sst signaling pathways modulates surgical stress-induced inhibition of gastric emptying and food intake. Methods Fasted rats were injected intracisternally (i.c.) with somatostatin agonists and underwent laparotomy and 1-min cecal palpation. GE of a non-nutrient solution and circulating acyl and desacyl ghrelin levels were assessed 50 min post surgery. Food intake was monitored for 24h. Key results The abdominal surgery-induced inhibition of GE (65%), food intake (73% at 2h) and plasma acyl ghrelin levels (67%) was completely prevented by ODT8-SST (1μg/rat, i.c.). The selective sst5 agonist, BIM-23052 prevented surgery-induced delayed GE, whereas selective sst1, sst2 or sst4 agonists had no effect. However, the selective sst2 agonist, S-346-011 (1μg/rat, i.c.) counteracted the abdominal surgery-induced inhibition of acyl ghrelin and food intake but not the delayed GE. The ghrelin receptor antagonist, [D-Lys3]-GHRP-6 (0.93 mg/kg, intraperitoneal, i.p.) blocked i.p. ghrelin-induced increased GE, while not influencing i.c. ODT8-SST-induced prevention of delayed GE and reduced food intake after surgery. Conclusions & Inferences ODT8-SST acts in the brain to prevent surgery-induced delayed GE likely via activating sst5. ODT8-SST and the sst2 agonist prevent the abdominal surgery-induced decrease in food intake and plasma acyl ghrelin indicating dissociation between brain somatostatin signaling involved in preventing surgery-induced suppression of GE and feeding response. PMID:21569179

Peptide receptor targeting in cancer: the somatostatin paradigm.

PubMed

Barbieri, Federica; Bajetto, Adriana; Pattarozzi, Alessandra; Gatti, Monica; Würth, Roberto; Thellung, Stefano; Corsaro, Alessandro; Villa, Valentina; Nizzari, Mario; Florio, Tullio

2013-01-01

Peptide receptors involved in pathophysiological processes represent promising therapeutic targets. Neuropeptide somatostatin (SST) is produced by specialized cells in a large number of human organs and tissues. SST primarily acts as inhibitor of endocrine and exocrine secretion via the activation of five G-protein-coupled receptors, named sst1-5, while in central nervous system, SST acts as a neurotransmitter/neuromodulator, regulating locomotory and cognitive functions. Critical points of SST/SST receptor biology, such as signaling pathways of individual receptor subtypes, homo- and heterodimerization, trafficking, and cross-talk with growth factor receptors, have been extensively studied, although functions associated with several pathological conditions, including cancer, are still not completely unraveled. Importantly, SST exerts antiproliferative and antiangiogenic effects on cancer cells in vitro, and on experimental tumors in vivo. Moreover, SST agonists are clinically effective as antitumor agents for pituitary adenomas and gastro-pancreatic neuroendocrine tumors. However, SST receptors being expressed by tumor cells of various tumor histotypes, their pharmacological use is potentially extendible to other cancer types, although to date no significant results have been obtained. In this paper the most recent findings on the expression and functional roles of SST and SST receptors in tumor cells are discussed.

The Role of SST and Large-Scale Dynamical Motions on the Onset and Shutdown of the Super Greenhouse Effect

NASA Astrophysics Data System (ADS)

O'Brien, T. A.; Kashinath, K.; Collins, W.

2015-12-01

Over warm tropical oceans the increase in greenhouse trapping with increasing SST is faster than that of the surface emission, resulting in a decrease in outgoing longwave radiation at the top of the atmosphere (OLR) when SST increases, also known as the super greenhouse effect (SGE). If SGE is directly linked to SST changes, there are profound implications for positive climate feedbacks in the tropics. However, a number of studies in the last 20 years have provided compelling evidence that the OLR-SST relationship is coincidental rather than causal. These studies suggested that the onset of SGE is dominated by the large-scale dynamics, and that the apparent OLR-SST relationships disappear when individual large-scale regimes are considered. We show that these conclusions are contingent on the quality of the datasets used in the analysis, and that modern satellite observations and reanalyses support a strong relationship between SGE and SST. We find that the SGE occurs across all dynamical regimes, suggesting that this may be related primarily to SST rather than large-scale dynamics. We also find that the discontinuity in the relationship between OLR and SST at high SST (29.5 C), i.e. the shutdown of SGE, also occurs across almost all dynamical regimes, suggesting that this behavior may also be strongly linked to SST. Collectively, these results suggest that the SGE may actually be controlled by SST. Work is ongoing to understand the robustness of this new result to other datasets, to understand whether SST is truly the controlling variable, and to understand the mechanism by which OLR could decrease with increasing SST even under strongly subsiding conditions.

Truncated somatostatin receptor 5 may modulate therapy response to somatostatin analogues--Observations in two patients with acromegaly and severe headache.

PubMed

Marina, Djordje; Burman, Pia; Klose, Marianne; Casar-Borota, Olivera; Luque, Raúl M; Castaño, Justo P; Feldt-Rasmussen, Ulla

2015-10-01

Somatotropinomas have unique "fingerprints" of somatostatin receptor (sst) expression, which are targets in treatment of acromegaly with somatostatin analogues (SSAs). However, a significant expression of sst is not always related to the biochemical response to SSAs. Headache is a common complaint in acromegaly and considered a clinical marker of disease activity. SSAs are reported to have an own analgesic effect, but the sst involved are unknown. We investigated sst expression in two acromegalic patients with severe headache and no biochemical effects of octreotide, but a good response to pasireotide. We searched the literature for determinants of biochemical and analgesic effects of SSAs in somatotropinomas. Case 1 had no biochemical or analgesic effects of octreotide, a semi-selective SSA, but a rapid and significant effect of pasireotide, a pan-SSA. Case 2 demonstrated discordance between analgesic and biochemical effects of octreotide, in that headache disappeared, but without biochemical improvement. In contrast, pasireotide normalized insulin-like growth factor 1. Both adenomas were sparsely granulated and had strong membranous expressions of sst2a in 50-75% and sst5 in 75-100% of tumor cells. The truncated sst5 variant TMD4 (sst5TMD4) showed expression in 20-57% of tumor cells. A poor biochemical response to octreotide may be associated with tumor expression of a truncated sst5 variant, despite abundant sst2a expression, suggesting an influence from variant sst5 on common sst signaling pathways. Furthermore, unrelated analgesic and biochemical effects of SSAs supported a complex pathogenesis of acromegaly-associated headache. Finally, assessment of truncated sst5 in addition to full length sst could be important for a choice of postoperative SSA treatment in somatotropinomas. Copyright © 2015 Elsevier Ltd. All rights reserved.

North American Tropical Cyclone Landfall and SST: A Statistical Model Study

NASA Technical Reports Server (NTRS)

Hall, Timothy; Yonekura, Emmi

2013-01-01

A statistical-stochastic model of the complete life cycle of North Atlantic (NA) tropical cyclones (TCs) is used to examine the relationship between climate and landfall rates along the North American Atlantic and Gulf Coasts. The model draws on archived data of TCs throughout the North Atlantic to estimate landfall rates at high geographic resolution as a function of the ENSO state and one of two different measures of sea surface temperature (SST): 1) SST averaged over the NA subtropics and the hurricane season and 2) this SST relative to the seasonal global subtropical mean SST (termed relSST). Here, the authors focus on SST by holding ENSO to a neutral state. Jackknife uncertainty tests are employed to test the significance of SST and relSST landfall relationships. There are more TC and major hurricane landfalls overall in warm years than cold, using either SST or relSST, primarily due to a basinwide increase in the number of storms. The signal along the coast, however, is complex. Some regions have large and significant sensitivity (e.g., an approximate doubling of annual major hurricane landfall probability on Texas from -2 to +2 standard deviations in relSST), while other regions have no significant sensitivity (e.g., the U.S. mid-Atlantic and Northeast coasts). This geographic structure is due to both shifts in the regions of primary TC genesis and shifts in TC propagation.

The Impact of High-Resolution Sea Surface Temperatures on the Simulated Nocturnal Florida Marine Boundary Layer

NASA Technical Reports Server (NTRS)

LaCasse, Katherine M.; Splitt, Michael E.; Lazarus, Steven M.; Lapenta, William M.

2008-01-01

High- and low-resolution sea surface temperature (SST) analysis products are used to initialize the Weather Research and Forecasting (WRF) Model for May 2004 for short-term forecasts over Florida and surrounding waters. Initial and boundary conditions for the simulations were provided by a combination of observations, large-scale model output, and analysis products. The impact of using a 1-km Moderate Resolution Imaging Spectroradiometer (MODIS) SST composite on subsequent evolution of the marine atmospheric boundary layer (MABL) is assessed through simulation comparisons and limited validation. Model results are presented for individual simulations, as well as for aggregates of easterly- and westerly-dominated low-level flows. The simulation comparisons show that the use of MODIS SST composites results in enhanced convergence zones. earlier and more intense horizontal convective rolls. and an increase in precipitation as well as a change in precipitation location. Validation of 10-m winds with buoys shows a slight improvement in wind speed. The most significant results of this study are that 1) vertical wind stress divergence and pressure gradient accelerations across the Florida Current region vary in importance as a function of flow direction and stability and 2) the warmer Florida Current in the MODIS product transports heat vertically and downwind of this heat source, modifying the thermal structure and the MABL wind field primarily through pressure gradient adjustments.

Selective agonists of somatostatin receptor subtype 1 or 2 injected peripherally induce antihyperalgesic effect in two models of visceral hypersensitivity in mice

PubMed Central

Mulak, Agata; Larauche, Muriel; Biraud, Mandy; Million, Mulugeta; Rivier, Jean; Taché, Yvette

2014-01-01

Somatostatin interacts with 5 G-protein-coupled receptor (sst1–5). Octreotide, a stable sst2≫3≥5 agonist, octreotide, exerts a visceral anti-hyperalgesic effect in experimental and clinical studies. Little is known on the receptor subtypes involved. We investigated the influence of the stable sst1–5 agonist, ODT8-SST and selective receptor subtype peptide agonists (3 or 10 μg/mouse) injected intraperitoneally (ip) on visceral hypersensitivity in mice induced by repeated noxious colorectal distensions (4 sets of 3 CRD, each at 55 mmHg) or corticotropin-releasing factor receptor 1 agonist, cortagine given between 2 sets of graded CRD (15, 30, 45, and 60 mmHg, 3 times each pressure). The mean visceromotor response (VMR) was assessed using a non-invasive manometry method and values were expressed as percentage of the VMR to the 1st set of CRD baseline or to the 60 mmHg CRD, respectively. ODT8-SST (10 μg) and the sst2 agonist, S-346-011 (3 and 10 μg) prevented mechanically-induced visceral hypersensitivity in the 3 sets of CRD, the sst1 agonist (10 μg) blocked only the 2nd set and showed a trend at 3 μg while the sst4 agonist had no effect. The selective sst2 antagonist, S-406-028 blocked the sst2 agonist but not the sst1 agonist effect. The sst1 agonist (3 and 10 μg) prevented cortagine-induced hypersensitivity to CRD at each pressure while the sst2 agonist at 10 μg reduced it. These data indicate that in addition to sst2, the sst1 agonist may provide a novel promising target to alleviate visceral hypersensitivity induced by mechanoreceptor sensitization and more prominently, stress-related visceral nociceptive sensitization. PMID:25451334

Selective agonists of somatostatin receptor subtype 1 or 2 injected peripherally induce antihyperalgesic effect in two models of visceral hypersensitivity in mice.

PubMed

Mulak, Agata; Larauche, Muriel; Biraud, Mandy; Million, Mulugeta; Rivier, Jean; Taché, Yvette

2015-01-01

Somatostatin interacts with five G-protein-coupled receptor (sst1-5). Octreotide, a stable sst2≫3≥5 agonist, exerts a visceral anti-hyperalgesic effect in experimental and clinical studies. Little is known on the receptor subtypes involved. We investigated the influence of the stable sst1-5 agonist, ODT8-SST and selective receptor subtype peptide agonists (3 or 10μg/mouse) injected intraperitoneally (ip) on visceral hypersensitivity in mice induced by repeated noxious colorectal distensions (four sets of three CRD, each at 55mmHg) or corticotropin-releasing factor receptor 1 agonist, cortagine given between two sets of graded CRD (15, 30, 45, and 60mmHg, three times each pressure). The mean visceromotor response (VMR) was assessed using a non-invasive manometry method and values were expressed as percentage of the VMR to the 1st set of CRD baseline or to the 60mmHg CRD, respectively. ODT8-SST (10μg) and the sst2 agonist, S-346-011 (3 and 10μg) prevented mechanically induced visceral hypersensitivity in the three sets of CRD, the sst1 agonist (10μg) blocked only the 2nd set and showed a trend at 3μg while the sst4 agonist had no effect. The selective sst2 antagonist, S-406-028 blocked the sst2 agonist but not the sst1 agonist effect. The sst1 agonist (3 and 10μg) prevented cortagine-induced hypersensitivity to CRD at each pressure while the sst2 agonist at 10μg reduced it. These data indicate that in addition to sst2, the sst1 agonist may provide a novel promising target to alleviate visceral hypersensitivity induced by mechanoreceptor sensitization and more prominently, stress-related visceral nociceptive sensitization. Copyright © 2014 Elsevier Inc. All rights reserved.

On the influence of simulated SST warming on rainfall projections in the Indo-Pacific domain: an AGCM study

NASA Astrophysics Data System (ADS)

Zhang, Huqiang; Zhao, Y.; Moise, A.; Ye, H.; Colman, R.; Roff, G.; Zhao, M.

2018-02-01

Significant uncertainty exists in regional climate change projections, particularly for rainfall and other hydro-climate variables. In this study, we conduct a series of Atmospheric General Circulation Model (AGCM) experiments with different future sea surface temperature (SST) warming simulated by a range of coupled climate models. They allow us to assess the extent to which uncertainty from current coupled climate model rainfall projections can be attributed to their simulated SST warming. Nine CMIP5 model-simulated global SST warming anomalies have been super-imposed onto the current SSTs simulated by the Australian climate model ACCESS1.3. The ACCESS1.3 SST-forced experiments closely reproduce rainfall means and interannual variations as in its own fully coupled experiments. Although different global SST warming intensities explain well the inter-model difference in global mean precipitation changes, at regional scales the SST influence vary significantly. SST warming explains about 20-25% of the patterns of precipitation changes in each of the four/five models in its rainfall projections over the oceans in the Indo-Pacific domain, but there are also a couple of models in which different SST warming explains little of their precipitation pattern changes. The influence is weaker again for rainfall changes over land. Roughly similar levels of contribution can be attributed to different atmospheric responses to SST warming in these models. The weak SST influence in our study could be due to the experimental setup applied: superimposing different SST warming anomalies onto the same SSTs simulated for current climate by ACCESS1.3 rather than directly using model-simulated past and future SSTs. Similar modelling and analysis from other modelling groups with more carefully designed experiments are needed to tease out uncertainties caused by different SST warming patterns, different SST mean biases and different model physical/dynamical responses to the same underlying SST forcing.

Seasonal trends of ACSPO VIIRS SST product characterized by the differences in orbital overlaps for various water types

NASA Astrophysics Data System (ADS)

Arnone, Robert; Vandermeulen, Ryan; Ignatov, Alexander; Cayula, Jean François

2015-05-01

The uncertainty of the Advanced Clear-Sky Processor for Oceans (ACSPO) Sea Surface Temperature (SST) products from the Visible Infrared Imaging Radiometer Suite (VIIRS) satellite is examined using consecutive orbital overlaps in coastal waters of the Gulf of Mexico. The overlapping region on the left and right side of the VIIRS swath at 23-35 degree latitude covers approximately 500 pixels, which occur within 100 minutes and can provide a total of 4 SST products (2 day and 2 night) per day. By assuming the ocean SST should be similar on each side of the swath in this short time period, diel changes are examined and the uncertainty of SST retrieval is determined by comparing with buoy-derived SST. The VIIRS ACSPO product from NOAA STAR was used to determine the difference in SST within the overlapping regions. These SST changes are evaluated between consecutive orbits to validate the accuracy of SST algorithms on each side of the swath at high sensor angles. The SST product differences across the swath can result from surface glint, sensor angular impacts and sensor characteristics such as half angle mirror side (HAM) and calibration. The absolute diurnal SST changes that can occur within 100 minutes are evaluated with the buoy and VIIRS-derived SST. Sensitivity of the SST to water types is evaluated by measuring diurnal differences for open ocean, shelf and coastal waters. The 100 minute VIIRS SST overlap shows the capability to monitor the diurnal ocean heating and cooling which are associated with water mass optical absorption. The seasonal trends of the difference in SST at the overlaps for these water masses were tracked on a monthly basis. The unique capability of using the same VIIRS sensor for self-characterization can provide a method to define the uncertainty of ocean products and characterize the diurnal changes for different water types.

F/FB-111 Avionics Test Station and Component Specialist/Technician. Automatic Test Stations Manual and Electronic Warfare Test Stations. Training Requirements Analysis (451X6). Volume 2

DTIC Science & Technology

1991-11-01

F-111D RADAR SST TASK NOTES: SST IS LOCATED ONLY AT CANNON AFB, NM. IT CONSISTS OF AN MRU , EPU, LVPS, MFG, DDPU, ARS RACK, AND TRANSMITTER. THE SST...VOTES: SST IS LOCATED ONLY AT CANNON AFB, NM. IT CONSISTS OF AN MRU , EPU, LVPS, MFG, DDPU, ARS RACK, AND TRANSMITTER. THE SST WILL BE REPLACED BY DTS...NOTES: SST IS LOCATED ONLY AT CANNON AFB, NM. IT CONSISTS OF AN MRU , EPU, LVPS, MFG, DDPU, ARS RACK, AND TRANSMITTER. THE SST WILL BE REPLACED BY DTS

Cogeneration steam turbines from Siemens: New solutions

NASA Astrophysics Data System (ADS)

Kasilov, V. F.; Kholodkov, S. V.

2017-03-01

The Enhanced Platform system intended for the design and manufacture of Siemens AG turbines is presented. It combines organizational and production measures allowing the production of various types of steam-turbine units with a power of up to 250 MWel from standard components. The Enhanced Platform designs feature higher efficiency, improved reliability, better flexibility, longer overhaul intervals, and lower production costs. The design features of SST-700 and SST-900 steam turbines are outlined. The SST-700 turbine is used in backpressure steam-turbine units (STU) or as a high-pressure cylinder in a two-cylinder condensing turbine with steam reheat. The design of an SST-700 single-cylinder turbine with a casing without horizontal split featuring better flexibility of the turbine unit is presented. An SST-900 turbine can be used as a combined IP and LP cylinder (IPLPC) in steam-turbine or combined-cycle power units with steam reheat. The arrangements of a turbine unit based on a combination of SST-700 and SST-900 turbines or SST-500 and SST-800 turbines are presented. Examples of this combination include, respectively, PGU-410 combinedcycle units (CCU) with a condensing turbine and PGU-420 CCUs with a cogeneration turbine. The main equipment items of a PGU-410 CCU comprise an SGT5-4000F gas-turbine unit (GTU) and STU consisting of SST-700 and SST-900RH steam turbines. The steam-turbine section of a PGU-420 cogeneration power unit has a single-shaft turbine unit with two SST-800 turbines and one SST-500 turbine giving a power output of N el. STU = 150 MW under condensing conditions.

A Fuzzy Control System for Reducing Urban Runoff by a Stormwater Storage Tank

NASA Astrophysics Data System (ADS)

Zhang, P.; Cai, Y.; Wang, J.

2017-12-01

Stormwater storage tank (SST) is a popular low impact development technology for reducing stormwater runoff in the construction of sponge city. Most researches on SST were mainly the design, pollutants removal effect, and operation assessment. While there were few researches on the automatic control of SST for reducing peak flow. In this paper, fuzzy control was introduced into the peak control of SST to improve the efficiency of reducing stormawter runoff. Firstly, the design of SST was investigated. A catchment area and return period were assumed, a SST model was manufactured, and then the storage capacity of the SST was verified. Secondly, the control parameters of the SST based on reducing stormwater runoff was analyzed, and a schematic diagram of real-time control (RTC) system based on peak control SST was established. Finally, fuzzy control system of a double input (flow and water level) and double output (inlet and outlet valve) was designed. The results showed that 1) under the different return periods (one year, three years, five years), the SST had the effect of delayed peak control and storage by increasing the detention time, 2) rainfall, pipeline flow, the influent time and the water level in the SST could be used as RTC parameters, and 3) the response curves of flow velocity and water level fluctuated very little and reached equilibrium in a short time. The combination of online monitoring and fuzzy control was feasible to control the SST automatically. This paper provides a theoretical reference for reducing stormwater runoff and improving the operation efficiency of SST.

Are Sea Surface Temperature satellite measurements reliable proxies of lagoon temperature in the South Pacific?

NASA Astrophysics Data System (ADS)

Van Wynsberge, Simon; Menkes, Christophe; Le Gendre, Romain; Passfield, Teuru; Andréfouët, Serge

2017-12-01

In remote coral reef environments, lagoon and reef in situ measurements of temperature are scarce. Sea Surface Temperature (SST) measured by satellite has been frequently used as a proxy of the lagoon temperature experienced by coral reef organisms (TL) especially during coral bleaching events. However, the link between SST and TL is poorly characterized. First, we compared the correlation between various SST series and TL from 2012 to 2016 in three atolls and one island in the Central South Pacific Ocean. Simple linear correlation between SST and TL ranged between 0.44 and 0.97 depending on lagoons, localities of sensors, and type of SST data. High-resolution-satellite-measurements of SST inside the lagoons did not outperform oceanic SST series, suggesting that SST products are not adapted for small lagoons. Second, we modelled the difference between oceanic SST and TL as a function of the drivers of lagoon water renewal and mixing, namely waves, tide, wind, and season. The multivariate models reduced significantly the bias between oceanic SST and TL. In atoll lagoons, and probably in other hydrodynamically semi-open systems, a correction taking into account these factors is necessary when SST are used to characterize organisms' thermal stress thresholds.

Somatostatin, neuronal vulnerability and behavioral emotionality.

PubMed

Lin, L C; Sibille, E

2015-03-01

Somatostatin (SST) deficits are common pathological features in depression and other neurological disorders with mood disturbances, but little is known about the contribution of SST deficits to mood symptoms or causes of these deficits. Here we show that mice lacking SST (Sst(KO)) exhibit elevated behavioral emotionality, high basal plasma corticosterone and reduced gene expression of Bdnf, Cortistatin and Gad67, together recapitulating behavioral, neuroendocrine and molecular features of human depression. Studies in Sst(KO) and heterozygous (Sst(HZ)) mice show that elevated corticosterone is not sufficient to reproduce the behavioral phenotype, suggesting a putative role for Sst cell-specific molecular changes. Using laser capture microdissection, we show that cortical SST-positive interneurons display significantly greater transcriptome deregulations after chronic stress compared with pyramidal neurons. Protein translation through eukaryotic initiation factor 2 (EIF2) signaling, a pathway previously implicated in neurodegenerative diseases, was most affected and suppressed in stress-exposed SST neurons. We then show that activating EIF2 signaling through EIF2 kinase inhibition mitigated stress-induced behavioral emotionality in mice. Taken together, our data suggest that (1) low SST has a causal role in mood-related phenotypes, (2) deregulated EIF2-mediated protein translation may represent a mechanism for vulnerability of SST neurons and (3) that global EIF2 signaling has antidepressant/anxiolytic potential.

Somatostatin, neuronal vulnerability and behavioral emotionality

PubMed Central

Lin, LC; Sibille, E

2014-01-01

Somatostatin (SST) deficits are common pathological features in depression and other neurological disorders with mood disturbances, but little is known about the contribution of SST deficits to mood symptoms or causes of these deficits. Here we show that mice lacking Sst (SstKO) exhibit elevated behavioral emotionality, high basal plasma corticosterone and reduced gene expression of Bdnf, Cortistatin, and Gad67, together recapitulating behavioral, neuroendocrine and molecular features of human depression. Studies in SstKO and heterozygous (SstHZ) mice show that elevated corticosterone is not sufficient to reproduce the behavioral phenotype, suggesting a putative role for Sst cell-specific molecular changes. Using laser-capture microdissection, we show that cortical SST-positive interneurons display significantly greater transcriptome deregulations after chronic stress compared to pyramidal neurons. Protein translation through eukaryotic initiation factor 2 (EIF2) signaling, a pathway previously implicated in neurodegenerative diseases, was most affected and suppressed in stress-exposed SST neurons. We then show that activating EIF2 signaling through EIF2 kinase inhibition mitigated stress-induced behavioral emotionality in mice. Together, our data suggest that (1) low SST plays a causal role in mood-related phenotypes, (2) deregulated EIF2-mediated protein translation may represent a mechanism for vulnerability of SST neurons, and (3) that global EIF2 signaling has antidepressant/anxiolytic potential. PMID:25600109

Comparison of MERRA-2 and ECCO-v4 ocean surface heat fluxes: Consequences of different forcing feedbacks on ocean circulation and implications for climate data assimilation.

NASA Astrophysics Data System (ADS)

Strobach, E.; Molod, A.; Menemenlis, D.; Forget, G.; Hill, C. N.; Campin, J. M.; Heimbach, P.

2017-12-01

Forcing ocean models with reanalysis data is a common practice in ocean modeling. As part of this practice, prescribed atmospheric state variables and interactive ocean SST are used to calculate fluxes between the ocean and the atmosphere. When forcing an ocean model with reanalysis fields, errors in the reanalysis data, errors in the ocean model and errors in the forcing formulation will generate a different solution compared to other ocean reanalysis solutions (which also have their own errors). As a first step towards a consistent coupled ocean-atmosphere reanalysis, we compare surface heat fluxes from a state-of-the-art atmospheric reanalysis, the Modern-Era Retrospective analysis for Research and Applications, Version 2 (MERRA-2), to heat fluxes from a state-of-the-art oceanic reanalysis, the Estimating the Circulation and Climate of the Ocean Version 4, Release 2 (ECCO-v4). Then, we investigate the errors associated with the MITgcm ocean model in its ECCO-v4 ocean reanalysis configuration (1992-2011) when it is forced with MERRA-2 atmospheric reanalysis fields instead of with the ECCO-v4 adjoint optimized ERA-interim state variables. This is done by forcing ECCO-v4 ocean with and without feedbacks from MERRA-2 related to turbulent fluxes of heat and moisture and the outgoing long wave radiation. In addition, we introduce an intermediate forcing method that includes only the feedback from the interactive outgoing long wave radiation. The resulting ocean circulation is compared with ECCO-v4 reanalysis and in-situ observations. We show that, without feedbacks, imbalances in the energy and the hydrological cycles of MERRA-2 (which are directly related to the fact it was created without interactive ocean) result in considerable SST drifts and a large reduction in sea level. The bulk formulae and interactive outgoing long wave radiation, although providing air-sea feedbacks and reducing model-data misfit, strongly relax the ocean to observed SST and may result in unwanted features such as large change in the water budget. These features have implications in on desired forcing recipe to be used. The results strongly and unambiguously argue for next generation data assimilation climate studies to involve fully coupled systems.

Variability in Bias of Gridded Sea Surface Temperature Data Products: Implications for Seasonally Resolved Marine Proxy Reconstructions

NASA Astrophysics Data System (ADS)

Ouellette, G., Jr.; DeLong, K. L.

2016-12-01

Seasonally resolved reconstructions of sea surface temperature (SST) are commonly produced using isotopic ratios and trace elemental ratios within the skeletal material of marine organisms such as corals, coralline algae, and mollusks. Using these geochemical proxies to produce paleoclimate reconstructions requires using regression methods to calibrate the proxy to observed SST, ideally with in situ SST records that span many years. Unfortunately, the few locations with in situ SST records rarely coincide with the time span of the marine proxy archive. Therefore, SST data products are often used for calibration and they are based on MOHSST or ICOADS SST observations as their main SST source but use different algorithms to produce globally gridded data products. These products include the Hadley Center's HADSST (5º) and interpolated HADISST (1º), NOAA's extended reconstructed SST (ERSST; 2º), optimum interpolation SST (OISST; 1º), and the Kaplan SST (5º). This study assessed the potential bias in these data products at marine archive sites throughout the tropical Atlantic using in situ SST where it was available, and a high-resolution (4 km) satellite-based SST data product from NOAA Pathfinder that has been shown to closely reflect in situ SST for our locations. Bias was assessed at each site, and then within each data product across the region for spatial homogeneity. Our results reveal seasonal biases in all data products, but not for all locations and not of a uniform magnitude or season among products. We found the largest differences in mean SST on the order of 1-3°C for single sites in the Gulf of Mexico, and differences for regional mean SST bias were 0.5-1°C when sites in the Gulf of Mexico were compared to sites in the Caribbean Sea within the same data product. No one SST data product outperformed the others and no systematic bias was found. This analysis illustrates regional strengths and weaknesses of these data products, and serves as a cautionary note against the wholesale use of a particular gridded data product for marine proxy calibration, whether for a single site or larger regional reconstruction, without considering the inherent heterogeneous bias present in each data product that we show varies among locations. Furthermore, this study has implications for comparing climate models and these SST data products.

The first experiments in SST-1

NASA Astrophysics Data System (ADS)

Pradhan, S.; Khan, Z.; Tanna, V. L.; Sharma, A. N.; Doshi, K. J.; Prasad, U.; Masand, H.; Kumar, Aveg; Patel, K. B.; Bhandarkar, M. K.; Dhongde, J. R.; Shukla, B. K.; Mansuri, I. A.; Varadarajulu, A.; Khristi, Y. S.; Biswas, P.; Gupta, C. N.; Sharma, D. K.; Raval, D. C.; Srinivasan, R.; Pandya, S. P.; Atrey, P. K.; Sharma, P. K.; Patel, P. J.; Patel, H. S.; Santra, P.; Parekh, T. J.; Dhanani, K. R.; Paravastu, Y.; Pathan, F. S.; Chauhan, P. K.; Khan, M. S.; Tank, J. K.; Panchal, P. N.; Panchal, R. N.; Patel, R. J.; George, S.; Semwal, P.; Gupta, P.; Mahesuriya, G. I.; Sonara, D. P.; Jayswal, S. P.; Sharma, M.; Patel, J. C.; Varmora, P. P.; Patel, D. J.; Srikanth, G. L. N.; Christian, D. R.; Garg, A.; Bairagi, N.; Babu, G. R.; Panchal, A. G.; Vora, M. M.; Singh, A. K.; Sharma, R.; Raju, D.; Kulkarni, S. V.; Kumar, M.; Manchanda, R.; Joisa, S.; Tahiliani, K.; Pathak, S. K.; Patel, K. M.; Nimavat, H. D.; Shah, P. R.; Chudasma, H. H.; Raval, T. Y.; Sharma, A. L.; Ojha, A.; Parghi, B. R.; Banaudha, M.; Makwana, A. R.; Chowdhuri, M. B.; Ramaiya, N.; kumar, A.; Raval, J. V.; Gupta, S.; Purohit, S.; Kaur, R.; Adhiya, A. N.; Jha, R.; Kumar, S.; Nagora, U. C.; Siju, V.; Thomas, J.; Chaudhari, V. R.; Patel, K. G.; Ambulkar, K. K.; Dalakoti, S.; Virani, C. G.; Parmar, P. R.; Thakur, A. L.; Das, A.; Bora, D.; the SST-1 Team

2015-10-01

A steady state superconducting tokamak (SST-1) has been commissioned after the successful experimental and engineering validations of its critical sub-systems. During the ‘engineering validation phase’ of SST-1; the cryostat was demonstrated to be leak-tight in all operational scenarios, 80 K thermal shields were demonstrated to be uniformly cooled without regions of ‘thermal runaway and hot spots’, the superconducting toroidal field magnets were demonstrated to be cooled to their nominal operational conditions and charged up to 1.5 T of the field at the major radius. The engineering validations further demonstrated the assembled SST-1 machine shell to be a graded, stress-strain optimized and distributed thermo-mechanical device, apart from the integrated vacuum vessel being validated to be UHV compatible etc. Subsequently, ‘field error components’ in SST-1 were measured to be acceptable towards plasma discharges. A successful breakdown in SST-1 was obtained in SST-1 in June 2013 assisted with electron cyclotron pre-ionization in the second harmonic mode, thus marking the ‘first plasma’ in SST-1 and the arrival of SST-1 into the league of contemporary steady state devices. Subsequent to the first plasma, successful repeatable plasma start-ups with E ˜ 0.4 V m-1, and plasma current in excess of 70 kA for 400 ms assisted with electron cyclotron heating pre-ionization at a field of 1.5 T have so far been achieved in SST-1. Lengthening the plasma pulse duration with lower hybrid current drive, confinement and transport in SST-1 plasmas and magnetohydrodynamic activities typical to large aspect ratio SST-1 discharges are presently being investigated in SST-1. In parallel, SST-1 has uniquely demonstrated reliable cryo-stable high field operation of superconducting TF magnets in the two-phase cooling mode, operation of vapour-cooled current leads with cold gas instead of liquid helium and an order less dc joint resistance in superconducting magnet winding packs with high transport currents. In parallel, SST-1 is also continually getting up-graded with first wall integration, superconducting central solenoid installation and over-loaded MgB2-brass based current leads etc. Phase-1 of SST-1 up-gradation is scheduled by the first half of 2015, after which long pulse plasma experiments in both circular and elongated configurations have been planned in SST-1.

Conceptual Final Paper on the Preliminary Design of an Oblique Flying Wing SST

NASA Technical Reports Server (NTRS)

Van der Velden, Alexander J. M.

1987-01-01

A conceptual Oblique Flying Wing Supersonic Transport Aircraft (OFW, or surfplane because of its shape) was first proposed in 1957. It was reintroduced in 1987 in view of the emerging technology of artificial stabilization. This paper is based on the performance and economics study of an M2 B747-100B replacement aircraft. In order to make a fair comparison of this configuration with the B747, an end-sixties structural technology level is assumed. It is shown that a modern stability and control system can balance the aircraft and smooth out gusts, and that the OFW configuration equals or outperforms the B747 in speed, economy and comfort.

Implementation and Validation of the Chien k-epsilon Turbulence Model in the Wind Navier-Stokes Code

NASA Technical Reports Server (NTRS)

Yoder, Dennis A.; Georgiadis, Nicholas J.

1999-01-01

The two equation k-epsilon turbulence model of Chien has been implemented in the WIND Navier-Stokes flow solver. Details of the numerical solution algorithm, initialization procedure, and stability enhancements are described. Results obtained with this version of the model are compared with those from the Chien k-epsilon model in the NPARC Navier-Stokes code and from the WIND SST model for three validation cases: the incompressible flow over a smooth flat plate, the incompressible flow over a backward facing step, and the shock-induced flow separation inside a transonic diffuser. The k-epsilon model results indicate that the WIND model functions very similarly to that in NPARC, though the WIND code appears to he slightly more accurate in the treatment of the near-wall region. Comparisons of the k-epsilon model results with those from the SST model were less definitive, as each model exhibited strengths and weaknesses for each particular case.

Changes in neuronal response to ischemia in retinas with genetic alterations of somatostatin receptor expression.

PubMed

Catalani, Elisabetta; Cervia, Davide; Martini, Davide; Bagnoli, Paola; Simonetti, Elisa; Timperio, Anna Maria; Casini, Giovanni

2007-03-01

Ischemia is a primary cause of neuronal death in retinal diseases. The repertoire of expressed transmitter receptors would determine the neurons' responses to ischemic damage, and peptidergic receptors may be involved. With a new in vitro model of the ischemic mouse retina, we investigated whether an altered expression of somatostatin receptors could modulate retinal responses to ischemia. We used retinas of somatostatin receptor 1 (sst(1)) knock out (KO) mice, where sst(2) are over-expressed and over-functional, and of sst(2) KO mice. TUNEL analysis of ischemic retinas showed a marked reduction of cell death in sst(1) KO retinas, while there were no differences between wild-type (WT) and sst(2) KO retinas. In addition, caspase-3 mRNA expression was also reduced in sst(1) KO as compared to WT retinas. An immunohistochemical analysis demonstrated that different cell populations responded differently to the ischemic insult, and that the persistence of some immunohistochemical markers was greater in sst(1) KO than in WT or in sst(2) KO retinas. In particular, rod bipolar cell survival was markedly improved in sst(1) KO retinas, while it was dramatically decreased in sst(2) KO retinas. Furthermore, consistent with a role of glutamate excitotoxicity in ischemia-induced neuronal death, retinal glutamate release was observed to increase under ischemic conditions, but this increase was significantly reduced in sst(1) KO retinas. These observations demonstrate that an increased presence of functional sst(2) protects against retinal ischemia, thus implementing the background for the use of sst(2) analogs in therapies of retinal diseases such as glaucoma or diabetic retinopathy.

Observations of Local Positive Low Cloud Feedback Patterns and Their Role in Internal Variability and Climate Sensitivity

NASA Astrophysics Data System (ADS)

Yuan, Tianle; Oreopoulos, Lazaros; Platnick, Steven E.; Meyer, Kerry

2018-05-01

Modeling studies have shown that cloud feedbacks are sensitive to the spatial pattern of sea surface temperature (SST) anomalies, while cloud feedbacks themselves strongly influence the magnitude of SST anomalies. Observational counterparts to such patterned interactions are still needed. Here we show that distinct large-scale patterns of SST and low-cloud cover (LCC) emerge naturally from objective analyses of observations and demonstrate their close coupling in a positive local SST-LCC feedback loop that may be important for both internal variability and climate change. The two patterns that explain the maximum amount of covariance between SST and LCC correspond to the Interdecadal Pacific Oscillation and the Atlantic Multidecadal Oscillation, leading modes of multidecadal internal variability. Spatial patterns and time series of SST and LCC anomalies associated with both modes point to a strong positive local SST-LCC feedback. In many current climate models, our analyses suggest that SST-LCC feedback strength is too weak compared to observations. Modeled local SST-LCC feedback strength affects simulated internal variability so that stronger feedback produces more intense and more realistic patterns of internal variability. To the extent that the physics of the local positive SST-LCC feedback inferred from observed climate variability applies to future greenhouse warming, we anticipate significant amount of delayed warming because of SST-LCC feedback when anthropogenic SST warming eventually overwhelm the effects of internal variability that may mute anthropogenic warming over parts of the ocean. We postulate that many climate models may be underestimating both future warming and the magnitude of modeled internal variability because of their weak SST-LCC feedback.

Highly Increased 125I-JR11 Antagonist Binding In Vitro Reveals Novel Indications for sst2 Targeting in Human Cancers.

PubMed

Reubi, Jean Claude; Waser, Beatrice; Mäcke, Helmut; Rivier, Jean

2017-02-01

There is recent in vitro and in vivo evidence that somatostatin receptor subtype 2 (sst 2 ) antagonists are better tools to target neuroendocrine tumors (NETs) than sst 2 agonists. Indeed, antagonists bind to a greater number of sst 2 sites than agonists. Whether sst 2 antagonists could be used successfully to target non-NETs, expressing low sst 2 density, is unknown. Here, we compare quantitatively 125 I-JR11 sst 2 antagonist binding in vitro with that of the sst 2 agonist 125 I-Tyr 3 -octreotide in large varieties of non-NET and NET. In vitro receptor autoradiography was performed with 125 I-JR11 and 125 I-Tyr 3 -octreotide in cancers from prostate, breast, colon, kidney, thyroid, and lymphoid tissues as well as NETs as reference. In general, 125 I-JR11 binds to many more sst 2 sites than 125 I-Tyr 3 -octreotide. In 13 breast cancers, 8 had a low binding (mean density, 844 ± 168 dpm/mg of tissue) with the agonist whereas 12 had a high binding (mean density, 4,447 ± 1,128 dpm/mg of tissue) with the antagonist. All 12 renal cell cancers showed a low binding of sst 2 with the agonist (mean density, 348 ± 49 dpm/mg of tissue) whereas all cases had a high sst 2 binding with the antagonist (mean density, 3,777 ± 582 dpm/mg of tissue). One of 5 medullary thyroid cancers was positive with the agonist, whereas 5 of 5 were positive with the antagonist. In 15 non-Hodgkin lymphomas, many more sst 2 sites were labeled with the antagonist than with the agonist. In 14 prostate cancers, none had sst 2 binding with the agonist and only 4 had a weak binding with the antagonist. None of 17 colon cancers showed sst 2 sites with the agonist, and only 3 cases were weakly positive with the antagonist. In the various tumor types, adjacent sst 2 -expressing tissues such as vessels, lymphocytes, nerves, mucosa, or stroma were more strongly labeled with the antagonist than with the agonist. The reference NET cases, incubated with a smaller amount of tracer, were also found to have many more sst 2 sites measured with the antagonist. All renal cell cancers and most breast cancers, non-Hodgkin lymphomas, and medullary thyroid cancers represent novel indications for the in vivo radiopeptide targeting of sst 2 by sst 2 antagonists, comparable to NET radiotargeting with sst 2 agonists. © 2017 by the Society of Nuclear Medicine and Molecular Imaging.

Molecular evidence and clinical importance of β-arrestins expression in patients with acromegaly.

PubMed

Coelho, Maria Caroline Alves; Vasquez, Marina Lipkin; Wildemberg, Luiz Eduardo; Vázquez-Borrego, Mari C; Bitana, Luciana; Camacho, Aline Helen da Silva; Silva, Débora; Ogino, Liana Lumi; Ventura, Nina; Chimelli, Leila; Luque, Raul M; Kasuki, Leandro; Gadelha, Mônica R

2018-04-01

β-arrestins seem to have a role in endocytosis and desensitization of somatostatin receptor subtype 2 (sst2) and could be associated with the responsiveness to somatostatin receptor ligands (SRL) in patients with acromegaly. To investigate the in vivo correlation between β-arrestins 1 and 2 with sst2, sst5 and dopamine receptor subtype 2 (D2) expressions, and the association of β-arrestins with response to first-generation SRL and invasiveness in somatotropinomas. β-arrestins 1 and 2, sst2, sst5 and D2 mRNA expressions were evaluated by quantitative real-time RT-PCR on tumoral tissue of 96 patients. Moreover, sst2 and sst5 protein expressions were also evaluated in 40 somatotropinomas by immunohistochemistry. Response to SRL, defined as GH <1 μg/l and normal IGF-I levels, was assessed in 40 patients. The Knosp-Steiner criteria were used to define invasiveness. Median β-arrestin 1, β-arrestin 2, sst2, sst5 and D2 mRNA copy numbers were 478; 9375; 731; 156; and 3989, respectively. There was a positive correlation between β-arrestins 1 and 2 (R = 0.444, P < 0.001). However, no correlation between β-arrestins and sst2, sst5 (mRNA and protein levels) or D2 was found. No association was found between β-arrestins expression and SRL responsiveness or tumour invasiveness. Although previous data suggest a putative correlation between β-arrestins and sst2, our data clearly indicated that no association existed between β-arrestins and sst2, sst5 or D2 expression, nor with response to SRL or tumour invasiveness. Therefore, further studies are required to clarify whether β-arrestins have a role in the response to treatment with SRL in acromegaly. © 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

Local increase of anticyclonic wave activity over northern Eurasia under amplified Arctic warming: WAVE ACTIVITY RESPONSE TO ARCTIC MELTING

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xue, Daokai; Lu, Jian; Sun, Lantao

In an attempt to resolve the controversy as to whether Arctic sea ice loss leads to more mid-latitude extremes, a metric of finite-amplitude wave activity is adopted to quantify the midlatitude wave activity and its change during the observed period of the drastic Arctic sea ice decline in both ERA Interim reanalysis data and a set of AMIP-type of atmospheric model experiments. Neither the experiment with the trend in the SST or that with the declining trend of Arctic sea ice can simulate the sizable midlatitude-wide reduction in the total wave activity (Ae) observed in the reanalysis, leaving its explanationmore » to the atmospheric internal variability. On the other hand, both the diagnostics of the flux of the local wave activity and the model experiments lend evidence to a possible linkage between the sea ice loss near the Barents and Kara seas and the increasing trend of anticyclonic local wave activity over the northern part of the central Eurasia and the associated impacts on the frequency of temperature extremes.« less

Novel sst2-selective somatostatin agonists. Three-dimensional consensus structure by NMR

PubMed Central

Grace, Christy Rani R.; Erchegyi, Judit; Koerber, Steven C.; Reubi, Jean Claude; Rivier, Jean; Riek, Roland

2008-01-01

The three-dimensional NMR structures of six octapeptide agonist analogues of somatostatin (SRIF) in the free form are described. These analogues, with the basic sequence H-DPhe/Phe2-c[Cys3-Xxx7-DTrp8-Lys9-Thr10-Cys14]-Thr-NH2 (the numbering refers to the position in native SRIF), with Xxx7 being Ala/Aph, exhibit potent and highly selective binding to human SRIF type 2 (sst2) receptors. The backbone of these sst2-selective analogues have the usual type-II’ β-turn reported in the literature for sst2/3/5-subtype-selective analogues. Correlating biological results and NMR studies led to the identification of the side chains of DPhe2, DTrp8 and Lys9 as the necessary components of the sst2 pharmacophore. This is the first study to show that the aromatic ring at position 7 (Phe7) is not critical for sst2 binding and that it plays an important role in sst3 and sst5 binding. This pharmacophore is therefore different from that proposed by others for sst2/3/5 analogues. PMID:16854054

Decadal time scale variability recorded in the Quelccaya summit ice core δ18O isotopic ratio series and its relation with the sea surface temperature

NASA Astrophysics Data System (ADS)

Mélice, J. L.; Roucou, P.

The spectral characteristics of the δ18O isotopic ratio time series of the Quelccaya ice cap summit core are investigated with the multi taper method (MTM), the singular spectrum analysis (SSA) and the wavelet transform (WT) techniques for the 500 y long 1485-1984 period. The most significant (at the 99.8% level) cycle according to the MTM F-test has a period centered at 14.4 y while the largest variance explaining oscillation according to the SSA technique has a period centered at 12.9 y. The stability over time of these periods is investigated by performing evolutive MTM and SSA on the 500 y long δ18O series with a 100 y wide moving window. It is shown that the cycles with largest amplitude and that the oscillations with largest extracting variance have corresponding periods aggregated around 13.5 y that are very stable over the period between 1485 and 1984. The WT of the same isotopic time series reveals the existence of a main oscillation around 12 y which are also very stable in time. The relation between the isotopic data at Quelccaya and the annual sea surface temperature (SST) field anomalies is then evaluated for the overlapping 1919-1984 period. Significant global correlation and significant coherency at 12.1 y are found between the isotopic series and the annual global sea surface temperature (GSST) series. Moreover, the correlation between the low (over 8 y) frequency component of the isotopic time series and the annual SST field point out significant values in the tropical North Atlantic. This region is characterized by a main SST variability at 12.8 y. The Quelccaya δ18O isotopic ratio series may therefore be considered as a good recorder of the tropical North Atlantic SSTs. This may be explained by the following mechanism: the water vapor amount evaporated by the tropical North Atlantic is function of the SST. So is the water vapor δ18O isotopic ratio. This water vapor is advected during the rainy season by northeast winds and precipitates at the Quelccaya summit with its tropical North Atlantic isotopic signature. It is also suggested from this described stability of the decadal time scale variability observed in the Quelccaya isotopic series, that the decadal time scale GSST variability was also stable during the last five centuries.

A reduction in the asymmetry of ENSO amplitude due to global warming: The role of atmospheric feedback

NASA Astrophysics Data System (ADS)

Ham, Yoo-Geun

2017-08-01

This study analyzes a reduction in the asymmetry of El Niño Southern-Oscillation (ENSO) amplitude due to global warming in Coupled Model Intercomparison Project Phase 5 models. The multimodel-averaged Niño3 skewness during December-February season decreased approximately 40% in the RCP4.5 scenario compared to that in the historical simulation. The change in the nonlinear relationship between sea surface temperature (SST) and precipitation is a key factor for understanding the reduction in ENSO asymmetry due to global warming. In the historical simulations, the background SST leading to the greatest precipitation sensitivity (SST for Maximum Precipitation Sensitivity, SST_MPS) occurs when the positive SST anomaly is located over the equatorial central Pacific. Therefore, an increase in climatological SST due to global warming weakens the atmospheric response during El Niño over the central Pacific. However, the climatological SST over this region in the historical simulation is still lower than the SST_MPS for the negative SST anomaly; therefore, a background SST increase due to global warming can further increase precipitation sensitivity. The atmospheric feedbacks during La Niña are enhanced and increase the La Niña amplitude due to global warming.

Cloning, Developmental, and Tissue-Specific Expression of Sucrose:Sucrose 1-Fructosyl Transferase from Taraxacum officinale. Fructan Localization in Roots1

PubMed Central

Van den Ende, Wim; Michiels, An; Van Wonterghem, Dominik; Vergauwen, Rudy; Van Laere, André

2000-01-01

Sucrose:sucrose 1-fructosyl transferase (1-SST) is the key enzyme initiating fructan synthesis in Asteraceae. Using reverse transcriptase-PCR, we isolated the cDNA for 1-SST from Taraxacum officinale. The cDNA-derived amino acid sequence showed very high homology to other Asteracean 1-SSTs (Cichorium intybus 86%, Cynara scolymus 82%, Helianthus tuberosus 80%), but homology to 1-SST from Allium cepa (46%) and Aspergillus foetidus (18%) was much lower. Fructan concentrations, 1-SST activities, 1-SST protein, and mRNA concentrations were compared in different organs during vegetative and generative development of T. officinale plants. Expression of 1-SST was abundant in young roots but very low in leaves. 1-SST was also expressed at the flowering stages in roots, stalks, and receptacles. A good correlation was found between northern and western blots showing transcriptional regulation of 1-SST. At the pre-flowering stage, 1-SST mRNA concentrations and 1-SST activities were higher in the root phloem than in the xylem, resulting in the higher fructan concentrations in the phloem. Fructan localization studies indicated that fructan is preferentially stored in phloem parenchyma cells in the vicinity of the secondary sieve tube elements. However, inulin-like crystals occasionally appeared in xylem vessels. PMID:10806226

Assessing recent warming using instrumentally homogeneous sea surface temperature records.

PubMed

Hausfather, Zeke; Cowtan, Kevin; Clarke, David C; Jacobs, Peter; Richardson, Mark; Rohde, Robert

2017-01-01

Sea surface temperature (SST) records are subject to potential biases due to changing instrumentation and measurement practices. Significant differences exist between commonly used composite SST reconstructions from the National Oceanic and Atmospheric Administration's Extended Reconstruction Sea Surface Temperature (ERSST), the Hadley Centre SST data set (HadSST3), and the Japanese Meteorological Agency's Centennial Observation-Based Estimates of SSTs (COBE-SST) from 2003 to the present. The update from ERSST version 3b to version 4 resulted in an increase in the operational SST trend estimate during the last 19 years from 0.07° to 0.12°C per decade, indicating a higher rate of warming in recent years. We show that ERSST version 4 trends generally agree with largely independent, near-global, and instrumentally homogeneous SST measurements from floating buoys, Argo floats, and radiometer-based satellite measurements that have been developed and deployed during the past two decades. We find a large cooling bias in ERSST version 3b and smaller but significant cooling biases in HadSST3 and COBE-SST from 2003 to the present, with respect to most series examined. These results suggest that reported rates of SST warming in recent years have been underestimated in these three data sets.

BIM-23A760 influences key functional endpoints in pituitary adenomas and normal pituitaries: molecular mechanisms underlying the differential response in adenomas

PubMed Central

Ibáñez-Costa, Alejandro; López-Sánchez, Laura M.; Gahete, Manuel D.; Rivero-Cortés, Esther; Vázquez-Borrego, Mari C.; Gálvez, María A.; de la Riva, Andrés; Venegas-Moreno, Eva; Jiménez-Reina, Luis; Moreno-Carazo, Alberto; Tinahones, Francisco J.; Maraver-Selfa, Silvia; Japón, Miguel A.; García-Arnés, Juan A.; Soto-Moreno, Alfonso; Webb, Susan M.; Kineman, Rhonda D.; Culler, Michael D.; Castaño, Justo P.; Luque, Raúl M.

2017-01-01

Chimeric somatostatin/dopamine compounds such as BIM-23A760, an sst2/sst5/D2 receptors-agonist, have emerged as promising new approaches to treat pituitary adenomas. However, information on direct in vitro effects of BIM-23A760 in normal and tumoral pituitaries remains incomplete. The objective of this study was to analyze BIM-23A760 effects on functional parameters (Ca2+ signaling, hormone expression/secretion, cell viability and apoptosis) in pituitary adenomas (n = 74), and to compare with the responses of normal primate and human pituitaries (n = 3–5). Primate and human normal pituitaries exhibited similar sst2/sst5/D2 expression patterns, wherein BIM-23A760 inhibited the expression/secretion of several pituitary hormones (specially GH/PRL), which was accompanied by increased sst2/sst5/D2 expression in primates and decreased Ca2+ concentration in human cells. In tumoral pituitaries, BIM-23A760 also inhibited Ca2+ concentration, hormone secretion/expression and proliferation. However, BIM-23A760 elicited stimulatory effects in a subset of GHomas, ACTHomas and NFPAs in terms of Ca2+ signaling and/or hormone secretion, which was associated with the relative somatostatin/dopamine-receptors levels, especially sst5 and sst5TMD4. The chimeric sst2/sst5/D2 compound BIM-23A760 affects multiple, clinically relevant parameters on pituitary adenomas and may represent a valuable therapeutic tool. The relative ssts/D2 expression profile, particularly sst5 and/or sst5TMD4 levels, might represent useful molecular markers to predict the ultimate response of pituitary adenomas to BIM-23A760. PMID:28181484

BIM-23A760 influences key functional endpoints in pituitary adenomas and normal pituitaries: molecular mechanisms underlying the differential response in adenomas.

PubMed

Ibáñez-Costa, Alejandro; López-Sánchez, Laura M; Gahete, Manuel D; Rivero-Cortés, Esther; Vázquez-Borrego, Mari C; Gálvez, María A; de la Riva, Andrés; Venegas-Moreno, Eva; Jiménez-Reina, Luis; Moreno-Carazo, Alberto; Tinahones, Francisco J; Maraver-Selfa, Silvia; Japón, Miguel A; García-Arnés, Juan A; Soto-Moreno, Alfonso; Webb, Susan M; Kineman, Rhonda D; Culler, Michael D; Castaño, Justo P; Luque, Raúl M

2017-02-09

Chimeric somatostatin/dopamine compounds such as BIM-23A760, an sst2/sst5/D 2 receptors-agonist, have emerged as promising new approaches to treat pituitary adenomas. However, information on direct in vitro effects of BIM-23A760 in normal and tumoral pituitaries remains incomplete. The objective of this study was to analyze BIM-23A760 effects on functional parameters (Ca 2+ signaling, hormone expression/secretion, cell viability and apoptosis) in pituitary adenomas (n = 74), and to compare with the responses of normal primate and human pituitaries (n = 3-5). Primate and human normal pituitaries exhibited similar sst2/sst5/D2 expression patterns, wherein BIM-23A760 inhibited the expression/secretion of several pituitary hormones (specially GH/PRL), which was accompanied by increased sst2/sst5/D2 expression in primates and decreased Ca 2+ concentration in human cells. In tumoral pituitaries, BIM-23A760 also inhibited Ca 2+ concentration, hormone secretion/expression and proliferation. However, BIM-23A760 elicited stimulatory effects in a subset of GHomas, ACTHomas and NFPAs in terms of Ca 2+ signaling and/or hormone secretion, which was associated with the relative somatostatin/dopamine-receptors levels, especially sst5 and sst5TMD4. The chimeric sst2/sst5/D 2 compound BIM-23A760 affects multiple, clinically relevant parameters on pituitary adenomas and may represent a valuable therapeutic tool. The relative ssts/D 2 expression profile, particularly sst5 and/or sst5TMD4 levels, might represent useful molecular markers to predict the ultimate response of pituitary adenomas to BIM-23A760.

Correcting infrared satellite estimates of sea surface temperature for atmospheric water vapor attenuation

NASA Technical Reports Server (NTRS)

Emery, William J.; Yu, Yunyue; Wick, Gary A.; Schluessel, Peter; Reynolds, Richard W.

1994-01-01

A new satellite sea surface temperature (SST) algorithm is developed that uses nearly coincident measurements from the microwave special sensor microwave imager (SSM/I) to correct for atmospheric moisture attenuation of the infrared signal from the advanced very high resolution radiometer (AVHRR). This new SST algorithm is applied to AVHRR imagery from the South Pacific and Norwegian seas, which are then compared with simultaneous in situ (ship based) measurements of both skin and bulk SST. In addition, an SST algorithm using a quadratic product of the difference between the two AVHRR thermal infrared channels is compared with the in situ measurements. While the quadratic formulation provides a considerable improvement over the older cross product (CPSST) and multichannel (MCSST) algorithms, the SSM/I corrected SST (called the water vapor or WVSST) shows overall smaller errors when compared to both the skin and bulk in situ SST observations. Applied to individual AVHRR images, the WVSST reveals an SST difference pattern (CPSST-WVSST) similar in shape to the water vapor structure while the CPSST-quadratic SST difference appears unrelated in pattern to the nearly coincident water vapor pattern. An application of the WVSST to week-long composites of global area coverage (GAC) AVHRR data demonstrates again the manner in which the WVSST corrects the AVHRR for atmospheric moisture attenuation. By comparison the quadratic SST method underestimates the SST corrections in the lower latitudes and overestimates the SST in th e higher latitudes. Correlations between the AVHRR thermal channel differences and the SSM/I water vapor demonstrate the inability of the channel difference to represent water vapor in the midlatitude and high latitudes during summer. Compared against drifting buoy data the WVSST and the quadratic SST both exhibit the same general behavior with the relatively small differences with the buoy temperatures.

A 20 year independent record of sea surface temperature for climate from Along-Track Scanning Radiometers

NASA Astrophysics Data System (ADS)

Merchant, Christopher J.; Embury, Owen; Rayner, Nick A.; Berry, David I.; Corlett, Gary K.; Lean, Katie; Veal, Karen L.; Kent, Elizabeth C.; Llewellyn-Jones, David T.; Remedios, John J.; Saunders, Roger

2012-12-01

A new record of sea surface temperature (SST) for climate applications is described. This record provides independent corroboration of global variations estimated from SST measurements made in situ. Infrared imagery from Along-Track Scanning Radiometers (ATSRs) is used to create a 20 year time series of SST at 0.1° latitude-longitude resolution, in the ATSR Reprocessing for Climate (ARC) project. A very high degree of independence of in situ measurements is achieved via physics-based techniques. Skin SST and SST estimated for 20 cm depth are provided, with grid cell uncertainty estimates. Comparison with in situ data sets establishes that ARC SSTs generally have bias of order 0.1 K or smaller. The precision of the ARC SSTs is 0.14 K during 2003 to 2009, from three-way error analysis. Over the period 1994 to 2010, ARC SSTs are stable, with better than 95% confidence, to within 0.005 K yr-1(demonstrated for tropical regions). The data set appears useful for cleanly quantifying interannual variability in SST and major SST anomalies. The ARC SST global anomaly time series is compared to the in situ-based Hadley Centre SST data set version 3 (HadSST3). Within known uncertainties in bias adjustments applied to in situ measurements, the independent ARC record and HadSST3 present the same variations in global marine temperature since 1996. Since the in situ observing system evolved significantly in its mix of measurement platforms and techniques over this period, ARC SSTs provide an important corroboration that HadSST3 accurately represents recent variability and change in this essential climate variable.

The Dependence of Cloud-SST Feedback on Circulation Regime and Timescale

NASA Astrophysics Data System (ADS)

Middlemas, E.; Clement, A. C.; Medeiros, B.

2017-12-01

Studies suggest cloud radiative feedback amplifies internal variability of Pacific sea surface temperature (SST) on interannual-and-longer timescales, though only a few modeling studies have tested the quantitative importance of this feedback (Bellomo et al. 2014b, Brown et al. 2016, Radel et al. 2016 Burgman et al. 2017). We prescribe clouds from a previous control run in the radiation module in Community Atmospheric Model (CAM5-slab), a method called "cloud-locking". By comparing this run to a control run, in which cloud radiative forcing can feedback on the climate system, we isolate the effect of cloud radiative forcing on SST variability. Cloud-locking prevents clouds from radiatively interacting with atmospheric circulation, water vapor, and SST, while maintaining a similar mean state to the control. On all timescales, cloud radiative forcing's influence on SST variance is modulated by the circulation regime. Cloud radiative forcing amplifies SST variance in subsiding regimes and dampens SST variance in convecting regimes. In this particular model, a tug of war between latent heat flux and cloud radiative forcing determines the variance of SST, and the winner depends on the timescale. On decadal-and-longer timescales, cloud radiative forcing plays a relatively larger role than on interannual-and-shorter timescales, while latent heat flux plays a smaller role. On longer timescales, the absence of cloud radiative feedback changes SST variance in a zonally asymmetric pattern in the Pacific Ocean that resembles an IPO-like pattern. We also present an analysis of cloud feedback's role on Pacific SST variability among preindustrial control CMIP5 models to test the model robustness of our results. Our results suggest that circulation plays a crucial role in cloud-SST feedbacks across the globe and cloud radiative feedbacks cannot be ignored when studying SST variability on decadal-and-longer timescales.

Inter-decadal variation of the Tropical Atlantic-Korea (TA-K) teleconnection pattern during boreal summer season

NASA Astrophysics Data System (ADS)

Ham, Yoo-Geun; Hwang, YeonJi; Lim, Young-Kwon; Kwon, Minho

2017-12-01

The inter-decadal variation of the positive relationship between the tropical Atlantic sea surface temperature (SST) and Korean precipitation during boreal summer season during 1900-2010 is examined. The 15-year moving correlation between the Tropical Atlantic SST (TAtlSST) index (SST anomalies from 30°S to 30°N and 60°W to 20°E) and Korean precipitation (precipitation anomalies from 35°-40°N to 120°-130°E) during June-July-August exhibits strong inter-decadal variation, which becomes positive at the 95% confidence level after the 1980s. Intensification of the linkage between the TAtlSST index and Korean precipitation after the 1980s is attributed to global warming via the increased background SST. The increase in the background SST over the Atlantic provides background conditions that enhance anomalous convective activity by anomalous Atlantic SST warming. Therefore, the overall atmospheric responses associated with the tropical Atlantic SST warming could intensify. The correlation between the TAtlSST index and Korean precipitation also exhibits strong inter-decadal variation within 1980-2010, which is over 0.8 during early 2000s, while it is relative low (i.e., around 0.6) during the early 1980s. The enhanced co-variability between the tropical and the mid-latitude Atlantic SST during the early 2000s indicates the intensification of TAtlSST-related Rossby wave source over the mid-latitude Atlantic, which excites stationary waves propagated from the Atlantic to the Korean peninsula across northern Europe and northeast Asia. This Rossby-wave train induces a cyclonic flow over the northern edge of the Korea, which intensifies southwesterly and results in precipitation over Korea. This observed decadal difference is well simulated by the stationary wave model experiments with a prescribed TAtlSST-related Rossby wave source over the mid-latitude Atlantic.

Comparison of the Northeast Arctic cod year class strength (at the age of 3+) with the SST anomalies in main spawning ground (the Norwegian Shelf Waters) by results of analysis satellite monitoring data during last years.

NASA Astrophysics Data System (ADS)

Vanyushin, George

2015-04-01

Continuous long-term database (1998-2014) on the sea surface temperature (SST) comprising results of regional satellite monitoring (the Norwegian and the Barents seas) is used to resolve several applied problems. Authors have analyzed indirect influence the SST (the NOAA satellite data) on modern cod total stock biomass (abundance of the Northeast Arctic cod at age 3+). In this study, we went on the consideration of the relationship between the SST anomalies for March-April in the main spawning ground of the cod off the Lofoten islands in the Norwegian Shelf Waters and forecasting assessment of future cod generation success and its future abundance of 3 year old. Mean monthly SST and SST anomalies are computed for the selected area on the basis of the weekly SST maps which made by using the NOAA satellites data for the period 1998-2014. Comparison of the SST anomalies in the main spawning ground with abundance of the cod year class at age 3+ shows that survival of the cod generations was inhibited on the whole as negative (below -0,1C) well as positive SST anomalies (above +1,3C) during March and April. Finally, the results indicate that poor and low middle generations of cod at age 3+ (2002, 2004, 2010) occurred in years with negative or extremely high positive the SST anomalies in the spawning area. The SST anomalies in years which were close to normal significances provide conditions for appearance middle or strong generations of cod (2001-2003, 2005-2009, 2011-2013). So, the SST and SST anomalies (by the NOAA satellite data) characterize of increase in input of warm Atlantic waters which form numerous eddies along the main stream thus creating favorable conditions for spawning and development of the cod larvae and fry and provide them with food stock, finally direct influence on forming total stock biomass of cod and helping its population forecast. Key words: satellite monitoring of SST, the Northeast Arctic cod, spawning ground, forecast of the cod year class strength at age 3+.

Search for Trends and Periodicities in Inter-hemispheric Sea Surface Temperature Difference

NASA Astrophysics Data System (ADS)

Rajesh, R.; Tiwari, R. K.

2018-02-01

Understanding the role of coupled solar and internal ocean dynamics on hemispheric climate variability is critical to climate modelling. We have analysed here 165 year long annual northern hemispheric (NH) and southern hemispheric (SH) sea surface temperature (SST) data employing spectral and statistical techniques to identify the imprints of solar and ocean-atmospheric processes, if any. We reconstructed the eigen modes of NH-SST and SH-SST to reveal non-linear oscillations superimposed on the monotonic trend. Our analysis reveals that the first eigen mode of NH-SST and SH-SST representing long-term trend of SST variability accounts for 15-23% variance. Interestingly, these components are matching with first eigen mode (99% variance) of the total solar irradiance (TSI) suggesting possible impact of solar activity on long-term SST variation. Furthermore, spectral analysis of SSA reconstructed signal revealed statistically significant periodicities of 63 ± 5, 22 ± 2, 10 ± 1, 7.6, 6.3, 5.2, 4.7, and 4.2 years in both NH-SST and SH-SST data. The major harmonics centred at 63 ± 5, 22 ± 2, and 10 ± 1 years are similar to solar periodicities and hence may represent solar forcing, while the components peaking at around 7.6, 6.3, 5.2, 4.7, and 4.2 years apparently falls in the frequency bands of El-Nino-Southern Oscillations linked to the oceanic internal processes. Our analyses also suggest evidence for the amplitude modulation of 9-11 and 21-22 year solar cycles, respectively, by 104 and 163 years in northern and southern hemispheric SST data. The absence of the above periodic oscillations in CO2 fails to suggest its role on observed inter-hemispheric SST difference. The cross-plot analysis also revealed strong influence of solar activity on linear trend of NH- and SH-SST in addition to small contribution from CO2. Our study concludes that (1) the long-term trends in northern and southern hemispheric SST variability show considerable synchronicity with cyclic warming and cooling phases and (2) the difference in cyclic forcing and non-linear modulations stemming from solar variability as a possible source of hemispheric SST differences.

Identification of the receptors for somatostatin (SST) and cortistatin (CST) in chickens and investigation of the roles of cSST28, cSST14, and cCST14 in inhibiting cGHRH1-27NH2-induced growth hormone secretion in cultured chicken pituitary cells.

PubMed

Meng, Fengyan; Huang, Guian; Gao, Shunyu; Li, Juan; Yan, Zhenxin; Wang, Yajun

2014-03-25

Somatostatin receptors (SSTRs) are proposed to mediate the actions of somatostatin (SST) and its related peptide, cortistatin (CST), in vertebrates. However, the identity, functionality, and tissue expression of these receptors remain largely unknown in most non-mammalian vertebrates including birds. In this study, five SSTRs (named cSSTR1, cSSTR2, cSSTR3, cSSTR4, cSSTR5) were cloned from chicken brain by RT-PCR. Using a pGL3-CRE-luciferase reporter system, we demonstrated that activation of each cSSTR expressed in CHO cells by cSST28, cSST14 and cCST14 treatment could inhibit forskolin-induced luciferase activity of CHO cells, indicating the functional coupling of all cSSTRs to Gi protein(s). Interestingly, cSSTR1-4 expressed in CHO cells could be activated by cSST28, cSST14 and cCST14 with high potencies, suggesting that they may function as the receptors common for these peptides. In contrast, cSSTR5 could be potently activated by cSST28 only, indicating that it is a cSST28-specific receptor. Using RT-PCR, wide expression of cSSTRs was detected in chicken tissues including pituitary. In accordance with their expression in pituitary, cSST28, cSST14, and cCST14 were demonstrated to inhibit basal and novel cGHRH1-27NH2-induced GH secretion in cultured chicken pituitary cells dose-dependently (0-10nM) by Western blot analysis, suggesting the involvement of cSSTR(s) common for these peptides in mediating their inhibitory actions. Collectively, our study establishes a molecular basis to elucidate the roles of SST/CST in birds and provide insights into the roles of SST/CST in vertebrates, such as their conserved actions on pituitary. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Remotely-sensed sea surface temperatuares (SST) of Northeaster Pacific Coastal Zones

EPA Science Inventory

Sea surface temperature (SST) is an important indicator of long-term trends and geographical temperature patterns; however there have been relatively few long-term records of SST in near-coastal habitats. In situ SST measurements are irregular in both space and time. Therefore, w...

The contrasting response of Hadley circulation to different meridional structure of sea surface temperature in CMIP5

NASA Astrophysics Data System (ADS)

Feng, Juan; Li, Jianping; Zhu, Jianlei; Li, Yang; Li, Fei

2018-02-01

The response of the Hadley circulation (HC) to the sea surface temperature (SST) is determined by the meridional structure of SST and varies according to the changing nature of this meridional structure. The capability of the models from the phase 5 of the Coupled Model Intercomparison Project (CMIP5) is utilized to represent the contrast response of the HC to different meridional SST structures. To evaluate the responses, the variations of HC and SST were linearly decomposed into two components: the equatorially asymmetric (HEA for HC, and SEA for SST) and equatorially symmetric (HES for HC, and SES for SST) components. The result shows that the climatological features of HC and tropical SST (including the spatial structures and amplitude) are reasonably simulated in all the models. However, the response contrast of HC to different SST meridional structures shows uncertainties among models. This may be due to the fact that the long-term temporal variabilities of HEA, HES, and SEA are limited reproduced in the models, although the spatial structures of their long-term variabilities are relatively reasonably simulated. These results indicate that the performance of the CMIP5 models to simulate long-term temporal variability of different meridional SST structures and related HC variations plays a fundamental role in the successful reproduction of the response of HC to different meridional SST structures.

Sea Surface Temperature Records Using Sr/Ca Ratios in a Siderastrea siderea Coral from SE Cuba

NASA Astrophysics Data System (ADS)

Fargher, H. A.; Hughen, K. A.; Ossolinski, J. E.; Bretos, F.; Siciliano, D.; Gonzalez, P.

2015-12-01

Sea surface temperature (SST) variability from Cuba remains relatively unknown compared to the rest of the Caribbean. Cuba sits near an inflection point in the spatial pattern of SST from the North Atlantic Oscillation (NAO), and long SST records from the region could reveal changes in the influence of this climate system through time. A Siderastrea siderea coral from the Jardínes de la Reina in southern Cuba was drilled to obtain a 220 year long archive of environmental change. The genus Siderastrea has not been extensively studied as an SST archive, yet Sr/Ca ratios in the Cuban core show a clear seasonal signal and strong correlation to instrumental SST data (r2 = 0.86 and 0.36 for monthly and interannual (winter season) timescales, respectively). Annual growth rates (linear extension) of the coral are observed to have a minor influence on Sr/Ca variability, but do not show a direct correlation to SST on timescales from annual to multidecadal. Sr/Ca measurements from the Cuban coral are used to reconstruct monthly and seasonal (winter, summer) SST extending back more than two centuries. Wintertime SST in southern Cuba is compared to other coral Sr/Ca records of winter-season SST from locations sensitive to the NAO in order to investigate the stationarity of the NAO SST 'fingerprint' through time.

Mean state dependence of ENSO diversity resulting from an intermediate coupled model

NASA Astrophysics Data System (ADS)

Xie, Ruihuang; Jin, Fei-Fei; Mu, Mu

2016-04-01

ENSO diversity is referred to the event-to-event differences in the amplitude, longitudinal location of maximum sea surface temperature (SST) anomalies and evolutional mechanisms, as manifested in both observation data and climate model simulations. Previous studies argued that westerly wind burst (WWB) has strong influence on ENSO diversity. Here, we bring evidences, from a modified intermediate complexity Zebiak-Cane (ZC) coupled model, to illustrate that the ENSO diversity is also determined by the mean states. Stabilities of the linearized ZC model reveal that the mean state with weak (strong) wind stress and deep (shallow) thermocline prefers ENSO variation in the equitorial eastern (central) Pacific with a four-year (two-year) period. Weak wind stress and deep thermocline make the thermocline (TH) feedback the dominant contribution to the growth of ENSO SST anomalies, whereas the opposite mean state favors the zonal advective (ZA) feedback. Different leading dynamical SST-controller makes ENSO display its diversity. In a mean state that resembles the recent climate in the tropical Pacific, the four-year and two-year ENSO variations coexist with similar growth rate. Even without WWB forcing, the nonlinear integration results with adjusted parameters in this special mean state also present at least two types of El Niño, in which the maximum warming rates are contributed by either TH or ZA feedback. The consistency between linear and nonlinear model results indicates that the ENSO diversity is dependent on the mean states.

Attributing extreme precipitation in the Black Sea region to sea surface warming

NASA Astrophysics Data System (ADS)

Meredith, Edmund; Semenov, Vladimir; Maraun, Douglas; Park, Wonsun; Chernokulsky, Alexander

2016-04-01

Higher sea surface temperatures (SSTs) warm and moisten the overlying atmosphere, increasing the low-level atmospheric instability, the moisture available to precipitating systems and, hence, the potential for intense convective systems. Both the Mediterranean and Black Sea regions have seen a steady increase in summertime SSTs since the early 1980s, by over 2 K in places. This raises the question of how this SST increase has affected convective precipitation extremes in the region, and through which mechanisms any effects are manifested. In particular, the Black Sea town of Krymsk suffered an unprecedented precipitation extreme in July 2012, which may have been influenced by Black Sea warming, causing over 170 deaths. To address this question, we adopt two distinct modelling approaches to event attribution and compare their relative merits. In the first, we use the traditional probabilistic event attribution approach involving global climate model ensembles representative of the present and a counterfactual past climate where regional SSTs have not increased. In the second, we use the conditional event attribution approach, taking the 2012 Krymsk precipitation extreme as a showcase example. Under the second approach, we carry out ensemble sensitivity experiments of the Krymsk event at convection-permitting resolution with the WRF regional model, and test the sensitivity of the event to a range of SST forcings. Both experiments show the crucial role of recent Black Sea warming in amplifying the 2012 Krymsk precipitation extreme. In the conditional event attribution approach, though, the explicit simulation of convective processes provides detailed insight into the physical mechanisms behind the extremeness of the event, revealing the dominant role of dynamical (i.e. static stability and vertical motions) over thermodynamical (i.e. increased atmospheric moisture) changes. Additionally, the wide range of SST states tested in the regional setup, which would be infeasible under the global modelling approach, reveal that the intensity of the Krymsk event responds highly nonlinearly to Black Sea warming and suggests a role for regional SST thresholds in more intense coastal convective extremes.

Variability of the Tropical Ocean Surface Temperatures at Decadal-Multidecadal Timescales. Part I: The Atlantic Ocean.

NASA Astrophysics Data System (ADS)

Mehta, Vikram M.

1998-09-01

Gridded time series from the Global Ocean Surface Temperature Atlas were analyzed with a variety of techniques to identify spatial structures and oscillation periods of the tropical Atlantic sea surface temperature (SST) variations at decadal timescales, and to develop physical interpretations of statistical patterns of decadal SST variations. Each time series was 110 yr (1882-1991) long. The tropical Atlantic SST variations were compared with decadal variations in a 74-yr-long (1912-85) north Nordeste Brazil rainfall time series and a 106-yr-long (1886-1991) tropical Atlantic cyclone activity index time series. The tropical Atlantic SST variations were also compared with decadal variations in the extratropical Atlantic SST.Multiyear to multidecadal variations in the cross-equatorial dipole pattern identified as a dominant empirical pattern of the tropical Atlantic SST variations in earlier and present studies are shown to be variations in the approximately north-south gradient of SST anomalies. It is also shown that there was no dynamical-thermodynamical, dipole mode of SST variations during the analysis period. There was a distinct decadal timescale (12-13 yr) of SST variations in the tropical South Atlantic, whereas no distinct decadal timescale was found in the tropical North Atlantic SST variations. Approximately 80% of the coherent decadal variance in the cross-equatorial SST gradient was `explained' by coherent decadal oscillations in the tropical South Atlantic SSTs. There were three, possibly physical, modes of decadal variations in the tropical Atlantic SSTs during the analysis period. In the more energetic mode of the North Atlantic decadal SST variations, anomalies traveled into the tropical North Atlantic from the extratropical North Atlantic along the eastern boundary of the basin. The anomalies strengthened and resided in the tropical North Atlantic for several years, then frequently traveled northward into the mid-high-latitude North Atlantic along the western boundary of the basin, and completed a clockwise rotation around the North Atlantic basin. In the less energetic North Atlantic decadal mode, SST anomalies originated in the tropical-subtropical North Atlantic near the African coast, and traveled northwestward and southward. In the South Atlantic decadal SST mode, anomalies either developed in situ or traveled into the tropical South Atlantic from the subtropical South Atlantic along the eastern boundary of the basin. The anomalies strengthened and resided in the tropical South Atlantic for several years, then frequently traveled southward into the subtropical South Atlantic along the western boundary of the basin, and completed a counterclockwise rotation around the South Atlantic basin. These decadal modes were not a permanent feature of the tropical Atlantic SST variations. The tropical North and South Atlantic SST anomalies frequently extended across the equator. Uncorrelated alignments of decadal SST anomalies having opposite signs on two sides of the equator occasionally created the apperance of a dipole.Independent analyses of the north Nordeste Brazil rainfall showed physical consistency and high coherence with the cross-equatorial SST gradient oscillations at 12-13-yr period. The tropical Atlantic cyclone index showed physical consistency but moderate coherence with the tropical North Atlantic decadal SST variations. The quasi-regularity of the 12-13-yr oscillations in the cross-equatorial SST gradient may provide an opportunity for long lead-time, skillful predictions of climate anomalies in the tropical Atlantic sector.

Gas Fuelling System for SST-1Tokamak

NASA Astrophysics Data System (ADS)

Dhanani, Kalpesh; Raval, D. C.; Khan, Ziauddin; Semwal, Pratibha; George, Siju; Paravastu, Yuvakiran; Thankey, Prashant; Khan, M. S.; Pradhan, Subrata

2017-04-01

SST-1 Tokamak, the first Indian Steady-state Superconducting experimental device is at present under operation in the Institute for Plasma Research. For plasma break down & initiation, piezoelectric valve based gas feed system is implemented as a primary requirement due to its precise control, easy handling, low construction and maintenance cost and its flexibility in the selection of the working gas. Hydrogen gas feeding with piezoelectric valve is used in the SST-1 plasma experiments. The piezoelectric valves used in SST-1 are remotely driven by a PXI based platform and are calibrated before each SST-1 plasma operation with precise control. This paper will present the technical development and the results of the gas fuelling system of SST-1.

Indian Ocean corals reveal crucial role of World War II bias for twentieth century warming estimates.

PubMed

Pfeiffer, M; Zinke, J; Dullo, W-C; Garbe-Schönberg, D; Latif, M; Weber, M E

2017-10-31

The western Indian Ocean has been warming faster than any other tropical ocean during the 20 th century, and is the largest contributor to the global mean sea surface temperature (SST) rise. However, the temporal pattern of Indian Ocean warming is poorly constrained and depends on the historical SST product. As all SST products are derived from the International Comprehensive Ocean-Atmosphere dataset (ICOADS), it is challenging to evaluate which product is superior. Here, we present a new, independent SST reconstruction from a set of Porites coral geochemical records from the western Indian Ocean. Our coral reconstruction shows that the World War II bias in the historical sea surface temperature record is the main reason for the differences between the SST products, and affects western Indian Ocean and global mean temperature trends. The 20 th century Indian Ocean warming pattern portrayed by the corals is consistent with the SST product from the Hadley Centre (HadSST3), and suggests that the latter should be used in climate studies that include Indian Ocean SSTs. Our data shows that multi-core coral temperature reconstructions help to evaluate the SST products. Proxy records can provide estimates of 20 th century SST that are truly independent from the ICOADS data base.

Increased serum concentrations of soluble ST2 predict mortality after burn injury.

PubMed

Hacker, Stefan; Dieplinger, Benjamin; Werba, Gregor; Nickl, Stefanie; Roth, Georg A; Krenn, Claus G; Mueller, Thomas; Ankersmit, Hendrik J; Haider, Thomas

2018-06-27

Large burn injuries induce a systemic response in affected patients. Soluble ST2 (sST2) acts as a decoy receptor for interleukin-33 (IL-33) and has immunosuppressive effects. sST2 has been described previously as a prognostic serum marker. Our aim was to evaluate serum concentrations of sST2 and IL-33 after thermal injury and elucidate whether sST2 is associated with mortality in these patients. We included 32 burn patients (total body surface area [TBSA] >10%) admitted to our burn intensive care unit and compared them to eight healthy probands. Serum concentrations of sST2 and IL-33 were measured serially using an enzyme-linked immunosorbent assay (ELISA) technique. The mean TBSA was 32.5%±19.6%. Six patients (18.8%) died during the hospital stay. Serum analyses showed significantly increased concentrations of sST2 and reduced concentrations of IL-33 in burn patients compared to healthy controls. In our study cohort, higher serum concentrations of sST2 were a strong independent predictor of mortality. Burn injuries cause an increment of sST2 serum concentrations with a concomitant reduction of IL-33. Higher concentrations of sST2 are associated with increased in-hospital mortality in burn patients.

Combined Effects of the North Atlantic Oscillation and the Arctic Oscillation on Sea Surface Temperature in the Alborán Sea

PubMed Central

Báez, José C.; Gimeno, Luis; Gómez-Gesteira, Moncho; Ferri-Yáñez, Francisco; Real, Raimundo

2013-01-01

We explored the possible effects of the North Atlantic Oscillation (NAO) and Arctic Oscillation (AO) on interannual sea surface temperature (SST) variations in the Alborán Sea, both separately and combined. The probability of observing mean annual SST values higher than average was related to NAO and AO values of the previous year. The effect of NAO on SST was negative, while that of AO was positive. The pure effects of NAO and AO on SST are obscuring each other, due to the positive correlation between them. When decomposing SST, NAO and AO in seasonal values, we found that variation in mean annual SST and mean winter SST was significantly related to the mean autumn NAO of the previous year, while mean summer SST was related to mean autumn AO of the previous year. The one year delay in the effect of the NAO and AO on the SST could be partially related to the amount of accumulated snow, as we found a significant correlation between the total snow in the North Alborán watershed for a year with the annual average SST of the subsequent year. A positive AO implies a colder atmosphere in the Polar Regions, which could favour occasional cold waves over the Iberian Peninsula which, when coupled with precipitations favoured by a negative NAO, may result in snow precipitation. This snow may be accumulated in the high peaks and melt down in spring-summer of the following year, which consequently increases the runoff of freshwater to the sea, which in turn causes a diminution of sea surface salinity and density, and blocks the local upwelling of colder water, resulting in a higher SST. PMID:23638005

Variable School Start Times and Middle School Student's Sleep Health and Academic Performance.

PubMed

Lewin, Daniel S; Wang, Guanghai; Chen, Yao I; Skora, Elizabeth; Hoehn, Jessica; Baylor, Allison; Wang, Jichuan

2017-08-01

Improving sleep health among adolescents is a national health priority and implementing healthy school start times (SSTs) is an important strategy to achieve these goals. This study leveraged the differences in middle school SST in a large district to evaluate associations between SST, sleep health, and academic performance. This cross-sectional study draws data from a county-wide surveillance survey. Participants were three cohorts of eighth graders (n = 26,440). The school district is unique because SST ranged from 7:20 a.m. to 8:10 a.m. Path analysis and probit regression were used to analyze associations between SST and self-report measures of weekday sleep duration, grades, and homework controlling for demographic variables (sex, race, and socioeconomic status). The independent contributions of SST and sleep duration to academic performance were also analyzed. Earlier SST was associated with decreased sleep duration (χ 2  = 173, p < .0001) and deficient sleep (≤7 hours) among 45% of students. Students with SST before 7:45 a.m. were at increased risk of decreased sleep duration, academic performance, and academic effort. Path analysis models demonstrated the independent contributions of sleep duration, SST, and variable effects for demographic variables. This is the first study to evaluate the independent contributions of SST and sleep to academic performance in a large sample of middle school students. Deficient sleep was prevalent, and the earliest SST was associated with decrements in sleep and academics. These findings support the prioritization of policy initiatives to implement healthy SST for younger adolescents and highlight the importance of sleep health education disparities among race and gender groups. Copyright © 2017 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

Selective central activation of somatostatin receptor 2 increases food intake, grooming behavior and rectal temperature in rats.

PubMed

Stengel, A; Goebel, M; Wang, L; Rivier, J; Kobelt, P; Monnikes, H; Tache, Y

2010-08-01

The consequences of selective activation of brain somatostatin receptor-2 (sst2) were assessed using the sst2 agonist, des-AA(1,4-6,11-13)-[DPhe(2),Aph7(Cbm),DTrp(8)]-Cbm-SST-Thr-NH2. Food intake (FI) was monitored in ad libitum fed rats chronically implanted with an intracerebroventricular (i.c.v.) cannula. The sst(2) agonist injected i.c.v. at 0.1 and 1 microg/rat dose-dependently increased light phase FI from 2 to 6 hours post injection (2.3+/-0.5 and 7.5+/-1.2 respectively vs. vehicle: 0.2+/-0.2 g/300 g bw, P<0.001). Peptide action was reversed by i.c.v. injection of the sst2 antagonist, des-AA(1,4-6,11-13)-[pNO(2)-Phe(2),DCys(3),Tyr(7),DAph(Cbm)8]-SST-2Nal-NH(2) and not reproduced by intraperitoneal injection (30 microg/rat). The sst(2) antagonist alone i.c.v. significantly decreased the cumulative 14-hours dark phase FI by 29.5%. Other behaviors, namely grooming, drinking and locomotor activity were also increased by the sst(2) agonist (1 microg/rat, i.c.v.) as monitored during the 2(nd) hour post injection while gastric emptying of solid food was unaltered. Rectal temperature rose 1 hour after the sst(2) agonist (1 microg/rat, i.c.v.) with a maximal response maintained from 1 to 4 hours post injection. These data show that selective activation of the brain sst(2) receptor induces a feeding response in the light phase not associated with changes in gastric emptying. The food intake reduction following sst(2) receptor blockade suggests a role of this receptor in the orexigenic drive during the dark phase.

Somatostatin Is Essential for the Sexual Dimorphism of GH Secretion, Corticosteroid-Binding Globulin Production, and Corticosterone Levels in Mice

PubMed Central

Adams, Jessica M.; Otero-Corchon, Veronica; Hammond, Geoffrey L.; Veldhuis, Johannes D.; Qi, Nathan

2015-01-01

Distinct male and female patterns of pituitary GH secretion produce sexually differentiated hepatic gene expression profiles, thereby influencing steroid and xenobiotic metabolism. We used a fully automated system to obtain serial nocturnal blood samples every 15 minutes from cannulated wild-type (WT) and somatostatin knockout (Sst-KO) mice to determine the role of SST, the principal inhibitor of GH release, in the generation of sexually dimorphic GH pulsatility. WT males had lower mean and median GH values, less random GH secretory bursts, and longer trough periods between GH pulses than WT females. Each of these parameters was feminized in male Sst-KO mice, whereas female Sst-KO mice had higher GH levels than all other groups, but GH pulsatility was unaffected. We next performed hepatic mRNA profiling with high-density microarrays. Male Sst-KO mice exhibited a globally feminized pattern of GH-dependent mRNA levels, but female Sst-KO mice were largely unaffected. Among the differentially expressed female-predominant genes was Serpina6, which encodes corticosteroid-binding globulin (CBG). Increased CBG was associated with elevated diurnal peak plasma corticosterone in unstressed WT females and both sexes of Sst-KO mice compared with WT males. Sst-KO mice also had exaggerated ACTH and corticosterone responses to acute restraint stress. However, consistent with their lack of phenotypic signs of excess glucocorticoids, cerebrospinal fluid concentrations of free corticosterone in Sst-KO mice were not elevated. In summary, SST is necessary for the prolonged interpulse troughs that define masculinized pituitary GH secretion. SST also contributes to sexual dimorphism of the hypothalamic-pituitary-adrenal axis via GH-dependent regulation of hepatic CBG production. PMID:25551181

Evaluation of somatostatin, CXCR4 chemokine and endothelin A receptor expression in a large set of paragangliomas.

PubMed

Kaemmerer, Daniel; Sänger, Jörg; Arsenic, Ruza; D'Haese, Jan G; Neumann, Jens; Schmitt-Graeff, Annette; Wirtz, Ralph Markus; Schulz, Stefan; Lupp, Amelie

2017-10-27

Paragangliomas are predominantly benign tumors, but in some cases invasive growth and also metastasis are observed. Given the limited number of nonsurgical treatment options, novel target structures for diagnostics and therapy of this tumor entity are urgently needed. In the present study, expression of all five somatostatin receptor (SST) subtypes, chemokine receptor CXCR4 and endothelin receptor type A (ETA) was assessed by means of immunohistochemistry in a total of 66 paraffin-embedded paraganglioma samples from 55 patients. The stainings were rated by means of the Immunoreactive Score and correlated to clinical data and to succinate dehydrogenase subunit B (SDHB) expression. SST2A was by far the most prominent receptor in the paragangliomas investigated. It was present in 89% of the tumors at a high intensity, followed by SST5, SST3, SST1 and SST4, which were detected in 47%, 35%, 35% and 13% of the samples, respectively. SDHB positive tumors exhibited significantly higher SST2A and SST3 expression as compared to SDHB negative cases. There was no correlation between SST and Ki-67 expression or grading of the tumors and no difference in SST expression between primary tumors and metastases. Cell surface expression of CXCR4 and ETA was detected only in few samples. On tumor capillaries, however, exceptionally strong staining for these two receptors was noticed in the vast majority of the tumors. In conclusion, paragangliomas are well suited for SST2A-based diagnostics and treatment modalities. An indirect targeting of these highly vascularized tumors via CXCR4 or ETA may also represent a promising future strategy.

Evaluation of somatostatin, CXCR4 chemokine and endothelin A receptor expression in a large set of paragangliomas

PubMed Central

Kaemmerer, Daniel; Sänger, Jörg; Arsenic, Ruza; D’Haese, Jan G.; Neumann, Jens; Schmitt-Graeff, Annette; Wirtz, Ralph Markus; Schulz, Stefan; Lupp, Amelie

2017-01-01

Paragangliomas are predominantly benign tumors, but in some cases invasive growth and also metastasis are observed. Given the limited number of nonsurgical treatment options, novel target structures for diagnostics and therapy of this tumor entity are urgently needed. In the present study, expression of all five somatostatin receptor (SST) subtypes, chemokine receptor CXCR4 and endothelin receptor type A (ETA) was assessed by means of immunohistochemistry in a total of 66 paraffin-embedded paraganglioma samples from 55 patients. The stainings were rated by means of the Immunoreactive Score and correlated to clinical data and to succinate dehydrogenase subunit B (SDHB) expression. SST2A was by far the most prominent receptor in the paragangliomas investigated. It was present in 89% of the tumors at a high intensity, followed by SST5, SST3, SST1 and SST4, which were detected in 47%, 35%, 35% and 13% of the samples, respectively. SDHB positive tumors exhibited significantly higher SST2A and SST3 expression as compared to SDHB negative cases. There was no correlation between SST and Ki-67 expression or grading of the tumors and no difference in SST expression between primary tumors and metastases. Cell surface expression of CXCR4 and ETA was detected only in few samples. On tumor capillaries, however, exceptionally strong staining for these two receptors was noticed in the vast majority of the tumors. In conclusion, paragangliomas are well suited for SST2A-based diagnostics and treatment modalities. An indirect targeting of these highly vascularized tumors via CXCR4 or ETA may also represent a promising future strategy. PMID:29163802

Understanding the effect of an excessive cold tongue bias on projecting the tropical Pacific SST warming pattern in CMIP5 models

NASA Astrophysics Data System (ADS)

Ying, Jun; Huang, Ping; Lian, Tao; Tan, Hongjian

2018-05-01

An excessive cold tongue is a common bias among current climate models, and considered an important source of bias in projections of tropical Pacific climate change under global warming. Specifically, the excessive cold tongue bias is closely related to the tropical Pacific SST warming (TPSW) pattern. In this study, we reveal that two processes are the critical mechanisms by which the excessive cold tongue bias influences the projection of the TPSW pattern, based on 32 models from phase 5 of Coupled Model Intercomparison Projection (CMIP5). On the one hand, by assuming that the shortwave (SW) radiation to SST feedback is linearly correlated to the cold tongue SST, the excessive cold tongue bias can induce an overly weak negative SW-SST feedback in the central Pacific, which can lead to a positive SST warming bias in the central to western Pacific (around 150°E-140°W). Moreover, the overly weak local atmospheric dynamics response to SST is a key process of the overly weak SW-SST feedback, compared with the cloud response to atmospheric dynamics and the SW radiation response to cloud. On the other hand, the overly strong ocean zonal overturning circulation associated with the excessive cold tongue bias results in an overestimation of the ocean dynamical thermostat effect, with enhanced ocean stratification under global warming, leading to a negative SST warming bias in the central and eastern Pacific (around 170°W-120°W). These two processes jointly form a positive SST warming bias in the western Pacific, contributing to a La Niña-like warming bias. Therefore, we suggest a more realistic climatological cold tongue SST is needed for a more reliable projection of the TPSW pattern.

Mechanisms underlying modulation of monocarboxylate transporter 1 (MCT1) by somatostatin in human intestinal epithelial cells.

PubMed

Saksena, Seema; Theegala, Saritha; Bansal, Nikhil; Gill, Ravinder K; Tyagi, Sangeeta; Alrefai, Waddah A; Ramaswamy, Krishnamurthy; Dudeja, Pradeep K

2009-11-01

Somatostatin (SST), an important neuropeptide of the gastrointestinal tract has been shown to stimulate sodium chloride absorption and inhibit chloride secretion in the intestine. However, the effects of SST on luminal butyrate absorption in the human intestine have not been investigated. Earlier studies from our group and others have shown that monocarboxylate transporter (MCT1) plays an important role in the transport of butyrate in the human intestine. The present studies were undertaken to examine the effects of SST on butyrate uptake utilizing postconfluent human intestinal epithelial Caco2 cells. Apical SST treatment of Caco-2 cells for 30-60 min significantly increased butyrate uptake in a dose-dependent manner with maximal increase at 50 nM ( approximately 60%, P < 0.05). SST receptor 2 agonist, seglitide, mimicked the effects of SST on butyrate uptake. SST-mediated stimulation of butyrate uptake involved the p38 MAP kinase-dependent pathway. Kinetic studies demonstrated that SST increased the maximal velocity (V(max)) of the transporter by approximately twofold without any change in apparent Michaelis-Menten constant (K(m)). The higher butyrate uptake in response to SST was associated with an increase in the apical membrane levels of MCT1 protein parallel to a decrease in the intracellular MCT1 pool. MCT1 has been shown to interact specifically with CD147 glycoprotein/chaperone to facilitate proper expression and function of MCT1 at the cell surface. SST significantly enhanced the membrane levels of CD147 as well as its association with MCT1. This association was completely abolished by the specific p38 MAP kinase inhibitor, SB203580. Our findings demonstrate that increased MCT1 association with CD147 at the apical membrane in response to SST is p38 MAP kinase dependent and underlies the stimulatory effects of SST on butyrate uptake.

Simulation of Tropical Rainfall Variability

NASA Astrophysics Data System (ADS)

Bader, J.; Latif, M.

2002-12-01

The impact of sea surface temperature (SST) - especially the role of the tropical Atlantic meridional SST gradient and the El Nino-Southern Oscillation - on precipitation is investigated with the atmospheric general circulation model ECHAM4/T42. Ensemble experiments - driven with observed SST - show that Atlantic SST has a significant influence on precipitation over West Africa and northeast Brazil. SST sensitivity experiments were performed in which the climatological SST was enhanced or decreased by one Kelvin in certain ocean areas. Changing SST in the eastern tropical Atlantic caused only significant changes along the Guinea Coast, with a positive anomaly (SSTA) increasing rainfall and a negative SSTA reducing it. The response was nearly linear. Changing SST in other ocean areas caused significant changes over West Africa, especially in the Sahel area. The response is found to be non linear, with only negative SSTA leading to significant reduction in Sahel rainfall. Also, the impact of the SSTAs from the different ocean regions was not additive with respect to the rainfall. The influence of SST on precipitation over northeast Brazil (Nordeste) was also investigated. Three experiments were performed in which the climatological SST was enhanced/decreased or decreased/enhanced by one Kelvin in the North/South Atlantic and increased by two Kelvin in the Nino3 ocean area. All experiments caused significant changes over Nordeste, with an enhanced/reduced SST gradient in the Atlantic increasing/reducing rainfall. The response was nearly linear. The main effect of the Atlantic SST gradient was a shift of the ITCZ, caused by trade wind changes. The ''El Nino'' event generates a significant reduction in Nordeste rainfall. A significant positive SLP anomaly occurs in northeast Brazil which may be associated with the descending branch of the Walker circulation. Also a significant positive SLP over the Atlantic from 30S to 10N north occurs. This results in a reduced SLP gradient from the subtropical highs to the equator and a weakening of the trade winds.

Cross-sectional associations between maternal parenting styles, physical activity and screen sedentary time in children.

PubMed

Van der Geest, K E; Mérelle, S Y M; Rodenburg, G; Van de Mheen, D; Renders, C M

2017-09-29

Children's activity level, including physical activity (PA) and screen sedentary time (SST), is influenced by environmental factors in which parents play a critical role. Different types of parenting styles may influence children's activity level. Inconsistent results were found on the association between parenting styles and PA, and few studies tested the association between parenting styles and SST. This study examined the association between parenting styles, PA and SST and the modifying effect of children's gender and maternal educational level on these associations. Cross-sectional data were collected from parents of children aged 8-11 years old who completed a web-based non-standardized questionnaire (N = 4047). Since 85% of the questionnaires were filled in by mothers, parenting styles are mainly reported by mothers. Multiple linear regression techniques were used to assess the associations between parenting styles (authoritative, permissive, authoritarian and neglectful), and PA and SST (mean min/day). The modifying effect of children's gender and maternal educational level on these associations was explored. P values ≤.0125 were considered as statistically significant based on the Bonferroni correction for four primary analyses. The neglectful parenting style was most widely used (35.3%), while the authoritarian style was least common (14.8%). No significant association was found between parenting styles and PA level. As regards SST, an authoritative parenting style was significantly associated with lower SST in boys while a neglectful parenting style was significantly associated with higher SST in both boys and girls. When the mother had a medium educational level, an authoritative parenting style was significantly associated with lower SST while neglectful parenting was significantly associated with higher SST. No association was found between parenting styles and PA. However, an authoritative parenting style was associated with a reduction in SST and a neglectful parenting style with an increase in SST, especially in boys and in children whose mother had a medium education level. Future studies of parenting practices are needed to gain more insight into the role of parents in children's PA and SST levels, as a basis for the development of interventions tailored to support parents in stimulating PA and reducing SST in children.

Remote sensing of SST in the coastal ocean and inland seas

NASA Astrophysics Data System (ADS)

Kostianoy, Andrey

Sea Surface Temperature (SST) is the main oceanographic parameter widely used in oceanogra-phy that can be easily obtained from satellite measurements. Oceanic infrared remote sensing, based on the measurement of the thermal radiance emitted by the ocean, allows retrieving the SST corresponding to the temperature of the uppermost thin layer of the ocean. Theoretically the infrared signal only comes from the upper few microns "skin layer", therefore the thermal signatures cannot represent the dynamics of the mixed layer. But wind mixing during the daytime and nighttime convection mix the upper layer, so that SST usually is representative of that of the mixed layer. This is why nighttime passes of satellites are preferred for SST analysis. Since 1978 the Advanced Very High Resolution Radiometer (AVHRR), onboard the meteorolog-ical satellites of the NOAA series are widely used to derive SST maps. The temporal coverage is ensured by two-three NOAA satellites which provide 4-6 images/day over the globe with a swath of about 2800 km, the spatial resolution by a pixel of about 1.1 km, and thermal resolu-tion of about 0.1 deg. C. The typical data processing includes the retrieval of the SST from the combination of NN 3, 4, and 5 infrared channels of AVHRR, the geographical correction and localisation, with a generation of cloud and land masks. SST data can be then composed into daily to monthly (as well as season to yearly) maps/products. Moderate Resolution Imaging Spectroradiometer (MODIS)-Terra (since 2000) and -Aqua (since 2002), among the others, are the most known satellite instruments which increase the flow of the remote sensing SST data. In the regions with almost permanent cloudy conditions passive microwave radiometers are of vital importance for SST measurements, but they have significantly low spatial (25 km) and thermal (0.8 deg. C) resolution. Today, SST images/data are routinely acquired by satellite receiving stations worldwide including research vessels, as well as generated and made available via Internet by numerous world data centers for free. Examples of SST application for analy-sis/study/research/monitoring of SST fields, SST fronts, large-and meso-scale water dynamics and structure (currents, eddies, dipoles, jets, etc.), upwellings, SST seasonal and interannual variability, etc. will be shown. Combined analysis of SST data with optical (ocean color), SAR, altimetry, in-situ oceanographic, drifter and meteorological data was shown to be very successful for many purposes in physical oceanography, environment research and operational monitoring, regional and global climate change study, marine chemistry, marine biology and fishery. The presentation will include examples for different case studies in the Arctic Ocean (the Barents and Kara seas), the Atlantic Ocean (the Canary and Benguela upwellings), the Southern Indian Ocean, the Mediterranean, Black, Caspian, Aral, and Baltic seas.

High-resolution modeling of local air-sea interaction within the Marine Continent using COAMPS

NASA Astrophysics Data System (ADS)

Jensen, T. G.; Chen, S.; Flatau, M. K.; Smith, T.; Rydbeck, A.

2016-12-01

The Maritime Continent (MC) is a region of intense deep atmospheric convection that serves as an important source of forcing for the Hadley and Walker circulations. The convective activity in the MC region spans multiple scales from local mesoscales to regional scales, and impacts equatorial wave propagation, coupled air-sea interaction and intra seasonal oscillations. The complex distribution of islands, shallow seas with fairly small heat storage and deep seas with large heat capacity is challenging to model. Diurnal convection over land-sea is part of a land-sea breeze system on a small scale, and is highly influenced by large variations in orography over land and marginal seas. Daytime solar insolation, run-off from the Archipelago and nighttime rainfall tends to stabilize the water column, while mixing by tidal currents and locally forced winds promote vertical mixing. The runoff from land and rivers and high net precipitation result in fresh water lenses that enhance vertical stability in the water column and help maintain high SST. We use the fully coupled atmosphere-ocean-wave version of the Coupled Ocean-Atmosphere Mesoscale Prediction System (COAMPS) developed at NRL with resolution of a few kilometers to investigate the air-sea interaction associated with the land-sea breeze system in the MC under active and inactive phases of the Madden-Julian Oscillation. The high resolution enables simulation of strong SST gradients associated with local upwelling in deeper waters and strong salinity gradients near rivers and from heavy precipitation.

Space-time VMS computation of wind-turbine rotor and tower aerodynamics

NASA Astrophysics Data System (ADS)

Takizawa, Kenji; Tezduyar, Tayfun E.; McIntyre, Spenser; Kostov, Nikolay; Kolesar, Ryan; Habluetzel, Casey

2014-01-01

We present the space-time variational multiscale (ST-VMS) computation of wind-turbine rotor and tower aerodynamics. The rotor geometry is that of the NREL 5MW offshore baseline wind turbine. We compute with a given wind speed and a specified rotor speed. The computation is challenging because of the large Reynolds numbers and rotating turbulent flows, and computing the correct torque requires an accurate and meticulous numerical approach. The presence of the tower increases the computational challenge because of the fast, rotational relative motion between the rotor and tower. The ST-VMS method is the residual-based VMS version of the Deforming-Spatial-Domain/Stabilized ST (DSD/SST) method, and is also called "DSD/SST-VMST" method (i.e., the version with the VMS turbulence model). In calculating the stabilization parameters embedded in the method, we are using a new element length definition for the diffusion-dominated limit. The DSD/SST method, which was introduced as a general-purpose moving-mesh method for computation of flows with moving interfaces, requires a mesh update method. Mesh update typically consists of moving the mesh for as long as possible and remeshing as needed. In the computations reported here, NURBS basis functions are used for the temporal representation of the rotor motion, enabling us to represent the circular paths associated with that motion exactly and specify a constant angular velocity corresponding to the invariant speeds along those paths. In addition, temporal NURBS basis functions are used in representation of the motion and deformation of the volume meshes computed and also in remeshing. We name this "ST/NURBS Mesh Update Method (STNMUM)." The STNMUM increases computational efficiency in terms of computer time and storage, and computational flexibility in terms of being able to change the time-step size of the computation. We use layers of thin elements near the blade surfaces, which undergo rigid-body motion with the rotor. We compare the results from computations with and without tower, and we also compare using NURBS and linear finite element basis functions in temporal representation of the mesh motion.

Space-Time VMS Computation of Wind-Turbine Rotor and Tower Aerodynamics

NASA Astrophysics Data System (ADS)

McIntyre, Spenser W.

This thesis is on the space{time variational multiscale (ST-VMS) computation of wind-turbine rotor and tower aerodynamics. The rotor geometry is that of the NREL 5MW offshore baseline wind turbine. We compute with a given wind speed and a specified rotor speed. The computation is challenging because of the large Reynolds numbers and rotating turbulent ows, and computing the correct torque requires an accurate and meticulous numerical approach. The presence of the tower increases the computational challenge because of the fast, rotational relative motion between the rotor and tower. The ST-VMS method is the residual-based VMS version of the Deforming-Spatial-Domain/Stabilized ST (DSD/SST) method, and is also called "DSD/SST-VMST" method (i.e., the version with the VMS turbulence model). In calculating the stabilization parameters embedded in the method, we are using a new element length definition for the diffusion-dominated limit. The DSD/SST method, which was introduced as a general-purpose moving-mesh method for computation of ows with moving interfaces, requires a mesh update method. Mesh update typically consists of moving the mesh for as long as possible and remeshing as needed. In the computations reported here, NURBS basis functions are used for the temporal representation of the rotor motion, enabling us to represent the circular paths associated with that motion exactly and specify a constant angular velocity corresponding to the invariant speeds along those paths. In addition, temporal NURBS basis functions are used in representation of the motion and deformation of the volume meshes computed and also in remeshing. We name this "ST/NURBS Mesh Update Method (STNMUM)." The STNMUM increases computational efficiency in terms of computer time and storage, and computational exibility in terms of being able to change the time-step size of the computation. We use layers of thin elements near the blade surfaces, which undergo rigid-body motion with the rotor. We compare the results from computations with and without tower, and we also compare using NURBS and linear finite element basis functions in temporal representation of the mesh motion.

The role of ocean-atmosphere interaction in Typhoon Sinlaku (2008) using a regional coupled data assimilation system

NASA Astrophysics Data System (ADS)

Wada, Akiyoshi; Kunii, Masaru

2017-05-01

For improving analyses of tropical cyclone (TC) and sea surface temperature (SST) and thereby TC simulations, a regional mesoscale strongly coupled atmosphere-ocean data assimilation system was developed with the local ensemble transform Kalman filter (LETKF) implemented with the Japan Meteorological Agency's nonhydrostatic model (NHM) coupled with a multilayer ocean model and the third-generation ocean wave model. The NHM-LETKF coupled data assimilation system was applied to Typhoon Sinlaku (2008) along with the original NHM-LETKF system to investigate the sensitivity of Sinlaku to SST assimilation with the Level 2 Pre-processed (L2P) standard product of satellite SST. SST calculated in the coupled-assimilation experiment with the coupled data assimilation system and the satellite SST (CPL) showed a better correlation with Optimally Interpolated SST than SST used in the control experiment with the original NHM-LETKF (CNTL) and SST calculated in the succession experiment with the coupled system without satellite SST (SUCC). The time series in the CPL experiment well captured the variation in the SST observed at the Kuroshio Extension Observation buoy site. In addition, TC-induced sea surface cooling was analyzed more realistically in the CPL experiment than that in the CNTL and SUCC experiments. However, the central pressure analyzed in each three experiments was overestimated compared with the Regional Specialized Meteorological Center Tokyo best-track central pressure, mainly due to the coarse horizontal resolution of 15 km. The 96 h TC simulations indicated that the CPL experiment provided more favorable initial and boundary conditions than the CNTL experiment to simulate TC tracks more accurately.

Somatostatin Signaling in Neuronal Cilia Is Criticalfor Object Recognition Memory

PubMed Central

Einstein, Emily B.; Patterson, Carlyn A.; Hon, Beverly J.; Regan, Kathleen A.; Reddi, Jyoti; Melnikoff, David E.; Mateer, Marcus J.; Schulz, Stefan; Johnson, Brian N.

2010-01-01

Most neurons possess a single, nonmotile cilium that projects out from the cell surface. These microtubule-based organelles are important in brain development and neurogenesis; however, their function in mature neurons is unknown. Cilia express a complement of proteins distinct from other neuronal compartments, one of which is the somatostatin receptor subtype SST3. We show here that SST3 is critical for object recognition memory in mice. sst3 knock-out mice are severely impaired in discriminating novel objects, whereas they retain normal memory for object location. Further, systemic injection of an SST3 antagonist (ACQ090) disrupts recall of familiar objects in wild-type mice. To examine mechanisms of SST3, we tested synaptic plasticity in CA1 hippocampus. Electrically evoked long-term potentiation (LTP) was normal in sst3 knock-out mice, while adenylyl cyclase/cAMP-mediated LTP was impaired. The SST3 antagonist also disrupted cAMP-mediated LTP. Basal cAMP levels in hippocampal lysate were reduced in sst3 knock-out mice compared with wild-type mice, while the forskolin-induced increase in cAMP levels was normal. The SST3 antagonist inhibited forskolin-stimulated cAMP increases, whereas the SST3 agonist L-796,778 increased basal cAMP levels in hippocampal slices but not hippocampal lysate. Our results show that somatostatin signaling in neuronal cilia is critical for recognition memory and suggest that the cAMP pathway is a conserved signaling motif in cilia. Neuronal cilia therefore represent a novel nonsynaptic compartment crucial for signaling involved in a specific form of synaptic plasticity and in novelty detection. PMID:20335466

A comparison of Argo nominal surface and near-surface temperature for validation of AMSR-E SST

NASA Astrophysics Data System (ADS)

Liu, Zenghong; Chen, Xingrong; Sun, Chaohui; Wu, Xiaofen; Lu, Shaolei

2017-05-01

Satellite SST (sea surface temperature) from the Advanced Microwave Scanning Radiometer for the Earth Observing System (AMSR-E) is compared with in situ temperature observations from Argo profiling floats over the global oceans to evaluate the advantages of Argo NST (near-surface temperature: water temperature less than 1 m from the surface). By comparing Argo nominal surface temperature ( 5 m) with its NST, a diurnal cycle caused by daytime warming and nighttime cooling was found, along with a maximum warming of 0.08±0.36°C during 14:00-15:00 local time. Further comparisons between Argo 5-m temperature/Argo NST and AMSR-E SST retrievals related to wind speed, columnar water vapor, and columnar cloud water indicate warming biases at low wind speed (<5 m/s) and columnar water vapor >28 mm during daytime. The warming tendency is more remarkable for AMSR-E SST/Argo 5-m temperature compared with AMSR-E SST/Argo NST, owing to the effect of diurnal warming. This effect of diurnal warming events should be excluded before validation for microwave SST retrievals. Both AMSR-E nighttime SST/Argo 5-m temperature and nighttime SST/Argo NST show generally good agreement, independent of wind speed and columnar water vapor. From our analysis, Argo NST data demonstrated their advantages for validation of satellite-retrieved SST.

Long-Term Trends, Variability and Extremes of In Situ Sea Surface Temperature Measured Along the Eastern Adriatic Coast and its Relationship to Hemispheric Processes

NASA Astrophysics Data System (ADS)

Grbec, Branka; Matić, Frano; Beg Paklar, Gordana; Morović, Mira; Popović, Ružica; Vilibić, Ivica

2018-02-01

This paper examines long-term series of in situ sea surface temperature (SST) data measured at nine coastal and one open sea stations along the eastern Adriatic Sea for the period 1959-2015. Monthly and yearly averages were used to document SST trends and variability, while clustering and connections to hemispheric indices were achieved by applying the Principal Component Analysis (PCA) and Self-Organizing Maps (SOM) method. Both PCA and SOM revealed the dominance of temporal changes with respect to the effects of spatial differences in SST anomalies, indicating the prevalence of hemispheric processes over local dynamics, such as bora wind spatial inhomogeneity. SST extremes were connected with blocking atmospheric patterns. A substantial warming between 1979 and 2015, in total exceeding 1 °C, was preceded by a period with a negative SST trend, implying strong multidecadal variability in the Adriatic. The strongest connection was found between yearly SST and the East Atlantic (EA) pattern, while North Atlantic Oscillation (NAO) and East Atlantic/West Russia (EAWR) patterns were found to also affect February SST values. Quantification of the Adriatic SST and their connection to hemispheric indices allow for more precise projections of future SST, considered to be rather important for Adriatic thermohaline circulation, biogeochemistry and fisheries, and sensitive to ongoing climate change.

Possible relationship between East Indian Ocean SST and tropical cyclone affecting Korea

NASA Astrophysics Data System (ADS)

Kim, J. Y.; Choi, K. S.; Kim, B. J.

2014-12-01

In this study, a strong negative correlation was found between East Indian Ocean (EIO) SST and frequency of summertime tropical cyclone (TC) affecting Korea.For the Warm EIO SST years, the TCs mostly occurred in the southwestern region of tropical and subtropical western Pacific, and migrated west toward the southern coast of China and Indochinese peninsula through the South China Sea. This is because the anomalous easterlies, induced by the development of anomalous anticyclone (weakening of monsoon trough) from the tropical central Pacific to the southern coast of China, served as the steering flows for the westward migration of TCs. In contrast, for the cold EIO SST years, the TCs mostly occurred in the northeastern region of tropical and subtropical western Pacific, and migrated toward Korea and Japan located in the mid-latitudes of East Asia through the East China Sea. This is because the northeastward retreat of subtropical western North Pacific high (SWNPH) was more distinct for the cold EIO SST years compared to the warm EIO SST years. Therefore, the TCs of warm EIO SST years weakened or dissipated shortly due to the effect of geographical features as they land on the southern coast of China and Indochinese peninsula, whereas the TCs of cold EIO SST years had stronger intensity than the TCs of warm EIO SST years as sufficient energy is supplied from the ocean while moving toward Korea and Japan.

Sea surface temperature: Observations from geostationary satellites

NASA Astrophysics Data System (ADS)

Bates, John J.; Smith, William L.

1985-11-01

A procedure is developed for estimating sea surface temperatures (SST) from multispectral image data acquired from the VISSR atmospheric sounder (VAS) on the geostationary GOES satellites. Theoretical regression equations for two and three infrared window channels are empirically tuned by using clear field of view satellite radiances matched with reports of SST from NOAA fixed environmental buoys from 1982. The empirical regression equations are then used to produce daily regional analyses of SST. The daily analyses are used to study the response of SST's to the passage of Hurricane Alicia (1983) and Hurricane Debbie (1982) and are also used as a first guess surface temperature in the retrieval of atmospheric temperature and moisture profiles over the oceanic regions. Monthly mean SST's for the western North Atlantic and the eastern equatorial Pacific during March and July 1982 were produced for use in the NASA/JPL SST intercomparison workshop series. Workshop results showed VAS SST's have a scatter of 0.8°-1.0°C and a slight warm bias with respect to the other measurements of SST. Subsequently, a second set of VAS/ buoy matches collected during 1983 and 1984 was used to produce a set of bias corrected regression relations for VAS.

Multi-scale Quantitative Precipitation Forecasting Using ...

EPA Pesticide Factsheets

Global sea surface temperature (SST) anomalies can affect terrestrial precipitation via ocean-atmosphere interaction known as climate teleconnection. Non-stationary and non-linear characteristics of the ocean-atmosphere system make the identification of the teleconnection signals difficult to be detected at a local scale as it could cause large uncertainties when using linear correlation analysis only. This paper explores the relationship between global SST and terrestrial precipitation with respect to long-term non-stationary teleconnection signals during 1981-2010 over three regions in North America and one in Central America. Empirical mode decomposition as well as wavelet analysis is utilized to extract the intrinsic trend and the dominant oscillation of the SST and precipitation time series in sequence. After finding possible associations between the dominant oscillation of seasonal precipitation and global SST through lagged correlation analysis, the statistically significant SST regions are extracted based on the correlation coefficient. With these characterized associations, individual contribution of these SST forcing regions linked to the related precipitation responses are further quantified through nonlinear modeling with the aid of extreme learning machine. Results indicate that the non-leading SST regions also contribute a salient portion to the terrestrial precipitation variability compared to some known leading SST regions. In some cases, these

Skills training for pregnancy and AIDS prevention in Anglo and Latino youth.

PubMed

Hovell, M; Blumberg, E; Sipan, C; Hofstetter, C R; Burkham, S; Atkins, C; Felice, M

1998-09-01

This study tested social skills training (SST), didactic training (DT), and no training (NT) on adolescents' social skills for resisting peer pressure to engage in acquired immunodeficiency syndrome (AIDS) and pregnancy risk behavior. A total of 307 Latino and Anglo youth ages 13-18 years were assigned at random to receive 18 h of SST, 18 h of DT, or NT. Significantly (p < 0.05) greater increases in assertiveness followed SST compared to DT or NT for three trained skills: condom negotiation, asking a friend about their sex/drug history, and discussing a friend's risk of AIDS. Untrained negotiation skills (e.g., purchasing a condom) did not increase significantly. SST did not result in increased assertiveness for refusal skills. DT increased knowledge of AIDS significantly more than SST; both DT and SST increased knowledge significantly more than NT. Social skills training can increase assertiveness for certain negotiation skills that may decrease risk of AIDS for Latino, Anglo, and male and female adolescents. Both DT and SST can increase knowledge of AIDS prevention. Differences between experimental groups were supported by differences between trained and untrained skills within the SST condition, adding to discriminant validity.

Sea surface temperature 1871-2099 in 14 cells around the United Kingdom.

PubMed

Sheppard, Charles

2004-07-01

Monthly sea surface temperature is provided for 14 locations around the UK for a 230 year period. These series are derived from the HadISST1 data set for historical time (1871-1999) and from the HadCM3 climate model for predicted SST (1950-2099). Two adjustments of the forecast data sets are needed to produce confluent SST series: the 50 year overlap is used for a gross adjustment, and a statistical scaling on the forecast data ensures that annual variations in forecast data match those of historical data. These monthly SST series are available on request. The overall rise in SST over time is clear for all sites, commencing in the last quarter of the 20th century. Apart from expected trends of overall warmer mean SST with more southerly latitudes and overall cooler mean SST towards the East, more interesting statistically significant general trends include a greater decadal rate of rise from warmer starting conditions. Annual temperature variation is not affected by absolute temperature, but is markedly greater towards the East. There is no correlation of annual range of SST with latitude, or with present SST values.

The numerical modeling the sensitivity of coastal wind and ozone concentration to different SST forcing

NASA Astrophysics Data System (ADS)

Choi, Hyun-Jung; Lee, Hwa Woon; Jeon, Won-Bae; Lee, Soon-Hwan

2012-01-01

This study evaluated an atmospheric and air quality model of the spatial variability in low-level coastal winds and ozone concentration, which are affected by sea surface temperature (SST) forcing with different thermal gradients. Several numerical experiments examined the effect of sea surface SST forcing on the coastal atmosphere and air quality. In this study, the RAMS-CAMx model was used to estimate the sensitivity to two different resolutions of SST forcing during the episode day as well as to simulate the low-level coastal winds and ozone concentration over a complex coastal area. The regional model reproduced the qualitative effect of SST forcing and thermal gradients on the coastal flow. The high-resolution SST derived from NGSST-O (New Generation Sea Surface Temperature Open Ocean) forcing to resolve the warm SST appeared to enhance the mean response of low-level winds to coastal regions. These wind variations have important implications for coastal air quality. A higher ozone concentration was forecasted when SST data with a high resolution was used with the appropriate limitation of temperature, regional wind circulation, vertical mixing height and nocturnal boundary layer (NBL) near coastal areas.

Western tropical Pacific multidecadal variability forced by the Atlantic multidecadal oscillation

NASA Astrophysics Data System (ADS)

Kucharski, F.; Sun, C.; Li, J.; Jin, F. F.; Kang, I. S.; Ding, R.

2017-12-01

Observational analysis suggests that the western tropical Pacific (WTP) sea surface temperature (SST) shows predominant variability over multidecadal time scales, which is unlikely to be explained by the Interdecadal Pacific Oscillation. Here we show that this variability is largely explained by the remote Atlantic multidecadal oscillation (AMO). A suite of Atlantic Pacemaker experiments successfully reproduces the WTP multidecadal variability and the AMO-WTP SST connection. The AMO warm SST anomaly generates an atmospheric teleconnection to the North Pacific, which weakens the Aleutian low and subtropical North Pacific westerlies. The wind changes induce a subtropical North Pacific SST warming through wind-evaporation-SST effect, and in response to this warming, the surface winds converge towards the subtropical North Pacific from the tropics, leading to anomalous cyclonic circulation and low pressure over the WTP region. The warm SST anomaly further develops due to the SST-sea level pressure-cloud-longwave radiation positive feedback. Our findings suggest that the Atlantic Ocean acts as a key pacemaker for the western Pacific decadal climate variability.

Modulation of the adaptive response to stress by brain activation of selective somatostatin receptor subtypes.

PubMed

Stengel, Andreas; Rivier, Jean; Taché, Yvette

2013-04-01

Somatostatin-14 was discovered in 1973 in the hypothalamus as a peptide inhibiting growth hormone release. Somatostatin interacts with five receptor subtypes (sst(1-5)) which are widely distributed in the brain with a distinct, but overlapping, expression pattern. During the last few years, the development of highly selective peptide agonists and antagonists provided new insight to characterize the role of somatostatin receptor subtypes in the pleiotropic actions of somatostatin. Recent evidence in rodents indicates that the activation of selective somatostatin receptor subtypes in the brain blunts stress-corticotropin-releasing factor (CRF) related ACTH release (sst2/5), sympathetic-adrenal activaton (sst5), stimulation of colonic motility (sst1), delayed gastric emptying (sst5), suppression of food intake (sst2) and the anxiogenic-like (sst2) response. These findings suggest that brain somatostatin signaling pathways may play an important role in dampening CRF-mediated endocrine, sympathetic, behavioral and visceral responses to stress. Published by Elsevier Inc.

Relationship between Trends in Land Precipitation and Tropical SST Gradient

NASA Technical Reports Server (NTRS)

Chung, Chul Eddy; Ramanathan, V.

2007-01-01

In this study, we examined global zonal/annual mean precipitation trends. Land precipitation trend from 1951 to 2002 shows widespread drying between 10 S to 20 N but the trend from 1977 to 2002 shows partial recovery. Based on general circulation model sensitivity studies, we suggested that these features are driven largely by the meridional SST gradient trend in the tropics. Our idealized CCM3 experiments substantiated that land precipitation is more sensitive to meridional SST gradient than to an overall tropical warming. Various simulations produced for the IPCC 4th assessment report demonstrate that increasing CO2 increases SST in the entire tropics non-uniformly and increases land precipitation only in certain latitude belts, again pointing to the importance of SST gradient change. Temporally varying aerosols in the IPCC simulations alter meridional SST gradient and land precipitation substantially. Anthropogenic aerosol direct solar forcing without its effects on SST is shown by the CCM3 to have weak but non-negligible influence on land precipitation.

Western tropical Pacific multidecadal variability forced by the Atlantic multidecadal oscillation

NASA Astrophysics Data System (ADS)

Sun, Cheng; Kucharski, Fred; Li, Jianping; Jin, Fei-Fei; Kang, In-Sik; Ding, Ruiqiang

2017-07-01

Observational analysis suggests that the western tropical Pacific (WTP) sea surface temperature (SST) shows predominant variability over multidecadal time scales, which is unlikely to be explained by the Interdecadal Pacific Oscillation. Here we show that this variability is largely explained by the remote Atlantic multidecadal oscillation (AMO). A suite of Atlantic Pacemaker experiments successfully reproduces the WTP multidecadal variability and the AMO-WTP SST connection. The AMO warm SST anomaly generates an atmospheric teleconnection to the North Pacific, which weakens the Aleutian low and subtropical North Pacific westerlies. The wind changes induce a subtropical North Pacific SST warming through wind-evaporation-SST effect, and in response to this warming, the surface winds converge towards the subtropical North Pacific from the tropics, leading to anomalous cyclonic circulation and low pressure over the WTP region. The warm SST anomaly further develops due to the SST-sea level pressure-cloud-longwave radiation positive feedback. Our findings suggest that the Atlantic Ocean acts as a key pacemaker for the western Pacific decadal climate variability.

Ocean heat budget analysis on sea surface temperature anomaly in western Indian Ocean during strong-weak Asian summer monsoon

NASA Astrophysics Data System (ADS)

Fathrio, Ibnu; Manda, Atsuyoshi; Iizuka, Satoshi; Kodama, Yasu-Masa; Ishida, Sachinobu

2018-05-01

This study presents ocean heat budget analysis on seas surface temperature (SST) anomalies during strong-weak Asian summer monsoon (southwest monsoon). As discussed by previous studies, there was close relationship between variations of Asian summer monsoon and SST anomaly in western Indian Ocean. In this study we utilized ocean heat budget analysis to elucidate the dominant mechanism that is responsible for generating SST anomaly during weak-strong boreal summer monsoon. Our results showed ocean advection plays more important role to initate SST anomaly than the atmospheric prcess (surface heat flux). Scatterplot analysis showed that vertical advection initiated SST anomaly in western Arabian Sea and southwestern Indian Ocean, while zonal advection initiated SST anomaly in western equatorial Indian Ocean.

Satellite monitoring temperature conditions spawning area of the Northeast Arctic cod in the Norwegian Sea and assessment its abundance

NASA Astrophysics Data System (ADS)

Vanyushin, George; Bulatova, Tatiana; Klochkov, Dmitriy; Troshkov, Anatoliy; Kruzhalov, Michail

2013-04-01

In this study, the attempt to consider the relationship between sea surface anomalies of temperature (SST anomalies °C) in spawning area of the Norwegian Arctic cod off the Lofoten islands in coastal zone of the Norwegian Sea and modern cod total stock biomass including forecasting assessment of future cod generation success. Continuous long-term database of the sea surface temperature (SST) was created on the NOAA satellites data. Mean monthly SST and SST anomalies are computed for the selected area on the basis of the weekly SST maps for the period of 1998-2012. These maps were plotted with the satellite SST data, as well as information of vessels, byoies and coastal stations. All data were classified by spawning seasons (March-April) and years. The results indicate that poor and low middle generations of cod (2001, 2006, 2007) occurred in years with negative or extremely high positive anomalies in the spawning area. The SST anomalies in years which were close to normal or some more normal significances provide conditions for appearance strong or very strong generations of cod (1998, 2000, 2002, 2004, 2005, 2006, 2008, 2009). Temperature conditions in concrete years influence on different indexes of cod directly. So, the mean temperature in spawning seasons in years 1999-2005 was ≈5,0°C and SST anomaly - +0,35°C, by the way average year significances indexes of cod were: total stock biomass - 1425,0 th.t., total spawning biomass - 460,0 th.t., recruitment (age 3+) - 535,0 mln. units and landings - 530,0 th.t. In spawning seasons 2006-2012 years the average data were following: mean SST ≈6,0°C, SST anomaly - +1,29°C, total stock biomass - 2185,0 th.t., total spawning biomass - 1211,0 th.t., recruitment (age 3+) - 821,0 mln. units and landings - 600,0 th.t. The SST and SST anomalies (the NOAA satellite data) characterize increase of decrease in input of warm Atlantic waters which form numerous eddies along the flows of the main warm currents thus creating favorable conditions for development of the cod larvae and fry and provide them with food stock, finally, direct influence on forming total stock biomass of cod and helping its population forecast. Key words: satellite monitoring of SST, Northeast Arctic cod, spawning area, maps of SST, prognosis.

Evaluating operational AVHRR sea surface temperature data at the coastline using surfers

NASA Astrophysics Data System (ADS)

Brewin, Robert J. W.; de Mora, Lee; Billson, Oliver; Jackson, Thomas; Russell, Paul; Brewin, Thomas G.; Shutler, Jamie D.; Miller, Peter I.; Taylor, Benjamin H.; Smyth, Tim J.; Fishwick, James R.

2017-09-01

Sea surface temperature (SST) is an essential climate variable that can be measured routinely from Earth Observation (EO) with high temporal and spatial coverage. To evaluate its suitability for an application, it is critical to know the accuracy and precision (performance) of the EO SST data. This requires comparisons with co-located and concomitant in situ data. Owing to a relatively large network of in situ platforms there is a good understanding of the performance of EO SST data in the open ocean. However, at the coastline this performance is not well known, impeded by a lack of in situ data. Here, we used in situ SST measurements collected by a group of surfers over a three year period in the coastal waters of the UK and Ireland, to improve our understanding of the performance of EO SST data at the coastline. At two beaches near the city of Plymouth, UK, the in situ SST measurements collected by the surfers were compared with in situ SST collected from two autonomous buoys located ∼7 km and ∼33 km from the coastline, and showed good agreement, with discrepancies consistent with the spatial separation of the sites. The in situ SST measurements collected by the surfers around the coastline, and those collected offshore by the two autonomous buoys, were used to evaluate the performance of operational Advanced Very High Resolution Radiometer (AVHRR) EO SST data. Results indicate: (i) a significant reduction in the performance of AVHRR at retrieving SST at the coastline, with root mean square errors in the range of 1.0 to 2.0 °C depending on the temporal difference between match-ups, significantly higher than those at the two offshore stations (0.4 to 0.6 °C); (ii) a systematic negative bias in the AVHRR retrievals of approximately 1 °C at the coastline, not observed at the two offshore stations; and (iii) an increase in the root mean square error at the coastline when the temporal difference between match-ups exceeded three hours. Harnessing new solutions to improve in situ sampling coverage at the coastline, such as tagging surfers with sensors, can improve our understanding of the performance of EO SST data in coastal regions, helping inform users interested in EO SST products for coastal applications. Yet, validating EO SST products using in situ SST data at the coastline is challenged by difficulties reconciling the two measurements, which are provided at different spatial scales in a dynamic and complex environment.

The effects of SST Gradients on Tropical Convective Systems and Implications for Tropical Cyclogenesis

NASA Astrophysics Data System (ADS)

Glazer, R.; Bourassa, M. A.; Hart, R. E.

2013-12-01

It has long been known that generally the warmer the sea surface temperature (SST), the more possible tropical cyclone (TC) genesis is, assuming the atmosphere is supportive. The conventional wisdom has been that - apart from what the TC cools through upwelling -- one value of SST represents the state of the ocean surface in the region of the storm's inner circulation. With the advent of the satellite era and fine resolution SST datasets now becoming available, we know that in reality there are gradients of SST across which developing TCs move. The influence of those gradients on tropical convection and TC genesis is largely unknown at this time. Previous studies have shown that SST gradients can significantly impact the overlying ocean surface winds leading to areas of enhanced convergence/divergence and Vorticity (Chelton et al. 2004; O'Neill et al. 2005, 2010). The magnitude of this effect approximately increases as the surface wind increases. Work by Minobe et al. (2008) concluded that a sharp SST Gradient, over the Gulf Stream for instance, could produce enough surface wind convergence to maintain a band of precipitation along the ocean front. An analysis of satellite derived SST data over the Atlantic shows that it is not uncommon for SST gradients of 2 C/200km or more to exist in the immediate environment of a Tropical System. The authors seek to understand whether the conclusions made in previous works can be applied in the case of a developing Tropical System and whether SST Gradients exist in the Tropical Atlantic to a degree that would influence the cyclogenesis process. To address this, the effects of SST gradients on tropical cyclogenesis processes are investigated using model simulations of the Weather Research and Forecasting Model (WRF). WRF is run at cloud permitting scales (2km) for real cases of co-location between a tropical system and an SST gradient exceeding 2 C/200km in the environment of the system. In subsequent runs to this control run, the SSTs are modified to give a smaller or larger SST Gradient with the same atmospheric conditions. All cases are chosen from Atlantic Hurricane Seasons between 2002-2011. The results are then analyzed in the framework of previous studies that have sought to model and understand tropical cyclogenesis using WRF (Nolan 2007; Fang and Zhang 2010).

On the spread of changes in marine low cloud cover in climate model simulations of the 21st century

NASA Astrophysics Data System (ADS)

Qu, Xin; Hall, Alex; Klein, Stephen A.; Caldwell, Peter M.

2014-05-01

In 36 climate change simulations associated with phases 3 and 5 of the Coupled Model Intercomparison Project (CMIP3 and CMIP5), changes in marine low cloud cover (LCC) exhibit a large spread, and may be either positive or negative. Here we develop a heuristic model to understand the source of the spread. The model's premise is that simulated LCC changes can be interpreted as a linear combination of contributions from factors shaping the clouds' large-scale environment. We focus primarily on two factors—the strength of the inversion capping the atmospheric boundary layer (measured by the estimated inversion strength, EIS) and sea surface temperature (SST). For a given global model, the respective contributions of EIS and SST are computed. This is done by multiplying (1) the current-climate's sensitivity of LCC to EIS or SST variations, by (2) the climate-change signal in EIS or SST. The remaining LCC changes are then attributed to changes in greenhouse gas and aerosol concentrations, and other environmental factors. The heuristic model is remarkably skillful. Its SST term dominates, accounting for nearly two-thirds of the intermodel variance of LCC changes in CMIP3 models, and about half in CMIP5 models. Of the two factors governing the SST term (the SST increase and the sensitivity of LCC to SST perturbations), the SST sensitivity drives the spread in the SST term and hence the spread in the overall LCC changes. This sensitivity varies a great deal from model to model and is strongly linked to the types of cloud and boundary layer parameterizations used in the models. EIS and SST sensitivities are also estimated using observational cloud and meteorological data. The observed sensitivities are generally consistent with the majority of models as well as expectations from prior research. Based on the observed sensitivities and the relative magnitudes of simulated EIS and SST changes (which we argue are also physically reasonable), the heuristic model predicts LCC will decrease over the 21st-century. However, to place a strong constraint, for example on the magnitude of the LCC decrease, will require longer observational records and a careful assessment of other environmental factors producing LCC changes. Meanwhile, addressing biases in simulated EIS and SST sensitivities will clearly be an important step towards reducing intermodel spread in simulated LCC changes.

Group for High Resolution Sea Surface Temperature (GHRSST) analysis fields inter-comparisons—Part 2: Near real time web-based level 4 SST Quality Monitor (L4-SQUAM)

NASA Astrophysics Data System (ADS)

Dash, Prasanjit; Ignatov, Alexander; Martin, Matthew; Donlon, Craig; Brasnett, Bruce; Reynolds, Richard W.; Banzon, Viva; Beggs, Helen; Cayula, Jean-Francois; Chao, Yi; Grumbine, Robert; Maturi, Eileen; Harris, Andy; Mittaz, Jonathan; Sapper, John; Chin, Toshio M.; Vazquez-Cuervo, Jorge; Armstrong, Edward M.; Gentemann, Chelle; Cummings, James; Piollé, Jean-François; Autret, Emmanuelle; Roberts-Jones, Jonah; Ishizaki, Shiro; Høyer, Jacob L.; Poulter, Dave

2012-11-01

There are a growing number of level 4 (L4; gap-free gridded) sea surface temperature (SST) products generated by blending SST data from various sources which are available for use in a wide variety of operational and scientific applications. In most cases, each product has been developed for a specific user community with specific requirements guiding the design of the product. Consequently differences between products are implicit. In addition, anomalous atmospheric conditions, satellite operations and production anomalies may occur which can introduce additional differences. This paper describes a new web-based system called the L4 SST Quality Monitor (L4-SQUAM) developed to monitor the quality of L4 SST products. L4-SQUAM intercompares thirteen L4 products with 1-day latency in an operational environment serving the needs of both L4 SST product users and producers. Relative differences between products are computed and visualized using maps, histograms, time series plots and Hovmöller diagrams, for all combinations of products. In addition, products are compared to quality controlled in situ SST data (available from the in situ SST Quality Monitor, iQUAM, companion system) in a consistent manner. A full history of products statistics is retained in L4-SQUAM for time series analysis. L4-SQUAM complements the two other Group for High Resolution SST (GHRSST) tools, the GHRSST Multi Product Ensemble (GMPE) and the High Resolution Diagnostic Data Set (HRDDS) systems, documented in part 1 of this paper and elsewhere, respectively. Our results reveal significant differences between SST products in coastal and open ocean areas. Differences of >2 °C are often observed at high latitudes partly due to different treatment of the sea-ice transition zone. Thus when an ice flag is available, the intercomparisons are performed in two ways: including and excluding ice-flagged grid points. Such differences are significant and call for a community effort to understand their root cause and ensure consistency between SST products. Future work focuses on including the remaining daily L4 SST products, accommodating for newer L4 SSTs which resolve the diurnal variability and evaluating retrospectively regenerated L4 SSTs to support satellite data reprocessing efforts aimed at generating improved SST Climate Data Records.

An evaluation of the effect of recent temperature variability on the prediction of coral bleaching events.

PubMed

Donner, Simon D

2011-07-01

Over the past 30 years, warm thermal disturbances have become commonplace on coral reefs worldwide. These periods of anomalous sea surface temperature (SST) can lead to coral bleaching, a breakdown of the symbiosis between the host coral and symbiotic dinoflagellates which reside in coral tissue. The onset of bleaching is typically predicted to occur when the SST exceeds a local climatological maximum by 1 degrees C for a month or more. However, recent evidence suggests that the threshold at which bleaching occurs may depend on thermal history. This study uses global SST data sets (HadISST and NOAA AVHRR) and mass coral bleaching reports (from Reefbase) to examine the effect of historical SST variability on the accuracy of bleaching prediction. Two variability-based bleaching prediction methods are developed from global analysis of seasonal and interannual SST variability. The first method employs a local bleaching threshold derived from the historical variability in maximum annual SST to account for spatial variability in past thermal disturbance frequency. The second method uses a different formula to estimate the local climatological maximum to account for the low seasonality of SST in the tropics. The new prediction methods are tested against the common globally fixed threshold method using the observed bleaching reports. The results find that estimating the bleaching threshold from local historical SST variability delivers the highest predictive power, but also a higher rate of Type I errors. The second method has the lowest predictive power globally, though regional analysis suggests that it may be applicable in equatorial regions. The historical data analysis suggests that the bleaching threshold may have appeared to be constant globally because the magnitude of interannual variability in maximum SST is similar for many of the world's coral reef ecosystems. For example, the results show that a SST anomaly of 1 degrees C is equivalent to 1.73-2.94 standard deviations of the maximum monthly SST for two-thirds of the world's coral reefs. Coral reefs in the few regions that experience anomalously high interannual SST variability like the equatorial Pacific could prove critical to understanding how coral communities acclimate or adapt to frequent and/or severe thermal disturbances.

Influences of Local Sea-Surface Temperatures and Large-scale Dynamics on Monthly Precipitation Inferred from Two 10-year GCM-Simulations

NASA Technical Reports Server (NTRS)

Sud, Y. C.; Walker, G. K.; Zhou, Y.; Lau, W. K.-M.

2007-01-01

Two parallel sets of 10-year long: January 1, 1982 to December 31, 1991, simulations were made with the finite volume General Circulation Model (fvGCM) in which the model integrations were forced with prescribed sea-surface temperature fields (SSTs) available as two separate SST-datasets. One dataset contained naturally varying monthly SSTs for the chosen period, and the oth& had the 12-monthly mean SSTs for the same period. Plots of evaporation, precipitation, and atmosphere-column moisture convergence, binned by l C SST intervals show that except for the tropics, the precipitation is more strongly constrained by large-scale dynamics as opposed to local SST. Binning data by SST naturally provided an ensemble average of data contributed from disparate locations with same SST; such averages could be expected to mitigate all location related influences. However, the plots revealed: i) evaporation, vertical velocity, and precipitation are very robust and remarkably similar for each of the two simulations and even for the data from 1987-ENSO-year simulation; ii) while the evaporation increased monotonically with SST up to about 27 C, the precipitation did not; iii) precipitation correlated much better with the column vertical velocity as opposed to SST suggesting that the influence of dynamical circulation including non-local SSTs is stronger than local-SSTs. The precipitation fields were doubly binned with respect to SST and boundary-layer mass and/or moisture convergence. The analysis discerned the rate of change of precipitation with local SST as a sum of partial derivative of precipitation with local SST plus partial derivative of precipitation with boundary layer moisture convergence multiplied by the rate of change of boundary-layer moisture convergence with SST (see Eqn. 3 of Section 4.5). This analysis is mathematically rigorous as well as provides a quantitative measure of the influence of local SST on the local precipitation. The results were recast to examine the dependence of local rainfall on local SSTs; it was discernible only in the tropics. Our methodology can be used for computing relationship between any forcing function and its effect(s) on a chosen field.

A dual but asymmetric role of the dorsal anterior cingulate cortex in response inhibition and switching from a non-salient to salient action

PubMed Central

Manza, Peter; Hu, Sien; Chao, Herta H.; Zhang, Sheng; Leung, Hoi-Chung; Li, Chiang-shan R.

2016-01-01

Response inhibition and salience detection are among the most studied psychological constructs of cognitive control. Despite a growing body of work, how inhibition and salience processing interact and engage regional brain activations remains unclear. Here, we examined this issue in a stop signal task (SST), where a prepotent response needs to be inhibited to allow an alternative, less dominant response. Sixteen adult individuals performed two versions of the SST each with 25% (SST25) and 75% (SST75) of stop trials. We posited that greater regional activations to the infrequent trial type in each condition (i.e., to stop as compared to go trials in SST25 and to go as compared to stop trials in SST75) support salience detection. Further, successful inhibition in stop trials requires attention to the stop signal to trigger motor inhibition, and the stop signal reaction time (SSRT) has been used to index the efficiency of motor response inhibition. Therefore, greater regional activations to stop as compared to go success trials in association with the stop signal reaction time (SSRT) serves to expedite response inhibition. In support of an interactive role, the dorsal anterior cingulate cortex (dACC) increases activation to salience detection in both SST25 and SST75, but only mediates response inhibition in SST75. Thus, infrequency response in the dACC supports motor inhibition only when stopping has become a routine. In contrast, although the evidence is less robust, the pre-supplementary motor area (pre-SMA) increases activity to the infrequent stimulus and supports inhibition in both SST25 and SST75. These findings clarify a unique role of the dACC and add to the literature that distinguishes dACC and pre-SMA functions in cognitive control. PMID:27126003

A dual but asymmetric role of the dorsal anterior cingulate cortex in response inhibition and switching from a non-salient to salient action.

PubMed

Manza, Peter; Hu, Sien; Chao, Herta H; Zhang, Sheng; Leung, Hoi-Chung; Li, Chiang-Shan R

2016-07-01

Response inhibition and salience detection are among the most studied psychological constructs of cognitive control. Despite a growing body of work, how inhibition and salience processing interact and engage regional brain activations remains unclear. Here, we examined this issue in a stop signal task (SST), where a prepotent response needs to be inhibited to allow an alternative, less dominant response. Sixteen adult individuals performed two versions of the SST each with 25% (SST25) and 75% (SST75) of stop trials. We posited that greater regional activations to the infrequent trial type in each condition (i.e., to stop as compared to go trials in SST25 and to go as compared to stop trials in SST75) support salience detection. Further, successful inhibition in stop trials requires attention to the stop signal to trigger motor inhibition, and the stop signal reaction time (SSRT) has been used to index the efficiency of motor response inhibition. Therefore, greater regional activations to stop as compared to go success trials in association with the stop signal reaction time (SSRT) serve to expedite response inhibition. In support of an interactive role, the dorsal anterior cingulate cortex (dACC) increases activation to salience detection in both SST25 and SST75, but only mediates response inhibition in SST75. Thus, infrequency response in the dACC supports motor inhibition only when stopping has become a routine. In contrast, although the evidence is less robust, the pre-supplementary motor area (pre-SMA) increases activity to the infrequent stimulus and supports inhibition in both SST25 and SST75. These findings clarify a unique role of the dACC and add to the literature that distinguishes dACC and pre-SMA functions in cognitive control. Copyright © 2016 Elsevier Inc. All rights reserved.

Understanding Southern Ocean SST Trends in Historical Simulations and Observations

NASA Astrophysics Data System (ADS)

Kostov, Yavor; Ferreira, David; Marshall, John; Armour, Kyle

2017-04-01

Historical simulations with CMIP5 global climate models do not reproduce the observed 1979-2014 Southern Ocean (SO) cooling, and most ensemble members predict gradual warming around Antarctica. In order to understand this discrepancy and the mechanisms behind the SO cooling, we analyze output from 19 CMIP5 models. For each ensemble member we estimate the characteristic responses of SO SST to step changes in greenhouse gas (GHG) forcing and in the seasonal indices of the Southern Annular Mode (SAM). Using these step-response functions and linear convolution theory, we reconstruct the original CMIP5 simulations of 1979-2014 SO SST trends. We recover the CMIP5 ensemble mean trend, capture the intermodel spread, and reproduce very well the behavior of individual models. We thus suggest that GHG forcing and the SAM are major drivers of the simulated 1979-2014 SO SST trends. In consistence with the seasonal signature of the Antarctic ozone hole, our results imply that the summer (DJF) and fall (MAM) SAM exert a particularly important effect on the SO SST. In some CMIP5 models the SO SST response to SAM partially counteracts the warming due to GHG forcing, while in other ensemble members the SAM-induced SO SST trends complement the warming effect of GHG forcing. The compensation between GHG and SAM-induced SO SST anomalies is model-dependent and is determined by multiple factors. Firstly, CMIP5 models have different characteristic SST step response functions to SAM. Kostov et al. (2016) relate these differences to biases in the models' climatological SO temperature gradients. Secondly, many CMIP5 historical simulations underestimate the observed positive trends in the DJF and MAM seasonal SAM indices. We show that this affects the models' ability to reproduce the observed SO cooling. Last but not least, CMIP5 models differ in their SO SST step response functions to GHG forcing. Understanding the diverse behavior of CMIP5 models helps shed light on the physical processes that drive SST trends in the real SO.

sST2 translation is regulated by FGF2 via an hnRNP A1-mediated IRES-dependent mechanism.

PubMed

Kunze, Michael M; Benz, Fabienne; Brauß, Thilo F; Lampe, Sebastian; Weigand, Julia E; Braun, Johannes; Richter, Florian M; Wittig, Ilka; Brüne, Bernhard; Schmid, Tobias

2016-07-01

Translation is an energy-intensive process and tightly regulated. Generally, translation is initiated in a cap-dependent manner. Under stress conditions, typically found within the tumor microenvironment in association with e.g. nutrient deprivation or hypoxia, cap-dependent translation decreases, and alternative modes of translation initiation become more important. Specifically, internal ribosome entry sites (IRES) facilitate translation of specific mRNAs under otherwise translation-inhibitory conditions. This mechanism is controlled by IRES trans-acting factors (ITAF), i.e. by RNA-binding proteins, which interact with and determine the activity of selected IRESs. We aimed at characterizing the translational regulation of the IL-33 decoy receptor sST2, which was enhanced by fibroblast growth factor 2 (FGF2). We identified and verified an IRES within the 5'UTR of sST2. Furthermore, we found that MEK/ERK signaling contributes to FGF2-induced, sST2-IRES activation and translation. Determination of the sST2-5'UTR structure by in-line probing followed by deletion analyses identified 23 nucleotides within the sST2-5'UTR to be required for optimal IRES activity. Finally, we show that the RNA-binding protein heterogeneous ribonucleoprotein A1 (hnRNP A1) binds to the sST2-5'UTR, acts as an ITAF, and thus controls the activity of the sST2-IRES and consequently sST2 translation. Specifically, FGF2 enhances nuclear-cytoplasmic translocation of hnRNP A1, which requires intact MEK/ERK activity. In summary, we provide evidence that the sST2-5'UTR contains an IRES element, which is activated by a MEK/ERK-dependent increase in cytoplasmic localization of hnRNP A1 in response to FGF2, enhancing the translation of sST2. Copyright © 2016 Elsevier B.V. All rights reserved.

Pathfinder Sea Surface Temperature Climate Data Record

NASA Astrophysics Data System (ADS)

Baker-Yeboah, S.; Saha, K.; Zhang, D.; Casey, K. S.

2016-02-01

Global sea surface temperature (SST) fields are important in understanding ocean and climate variability. The NOAA National Centers for Environmental Information (NCEI) develops and maintains a high resolution, long-term, climate data record (CDR) of global satellite SST. These SST values are generated at approximately 4 km resolution using Advanced Very High Resolution Radiometer (AVHRR) instruments aboard NOAA polar-orbiting satellites going back to 1981. The Pathfinder SST algorithm is based on the Non-Linear SST algorithm using the modernized NASA SeaWiFS Data Analysis System (SeaDAS). Coefficients for this SST product were generated using regression analyses with co-located in situ and satellite measurements. Previous versions of Pathfinder included level 3 collated (L3C) products. Pathfinder Version 5.3 includes level 2 pre-processed (L2P), level 3 Uncollated (L3C), and L3C products. Notably, the data were processed in the cloud using Amazon Web Services and are made available through all of the modern web visualization and subset services provided by the THREDDS Data Server, the Live Access Server, and the OPeNDAP Hyrax Server.In this version of Pathfinder SST, anomalous hot-spots at land-water boundaries are better identified and the dataset includes updated land masks and sea ice data over the Antarctic ice shelves. All quality levels of SST values are generated, giving the user greater flexibility and the option to apply their own cloud-masking procedures. Additional improvements include consistent cloud tree tests for NOAA-07 and NOAA-19 with respect to the other sensors, improved SSTs in sun glint areas, and netCDF file format improvements to ensure consistency with the latest Group for High Resolution SST (GHRSST) requirements. This quality controlled satellite SST field is a reference environmental data record utilized as a primary resource of SST for numerous regional and global marine efforts.

Low frequency North Atlantic SST variability: Weather noise forcing and coupled response

NASA Astrophysics Data System (ADS)

Fan, Meizhu

A method to diagnose the causes of low frequency SST variability is developed, tested and applied in an ideal case and real climate. In the ideal case, a free simulation of the COLA CGCM is taken as synthetic observations. For real climate, we take NCEP reanalysis atmospheric data and Reynolds SST as observations. Both the synthetic and actual observation data show that weather noise is the main component of atmospheric variability at subtropics and high-latitude. Diagnoses of results from the ideal case suggest that most of the synthetic observed SST variability can be reproduced by the weather noise surface fluxes forcing. This includes the "observed" low frequency SST patterns in the North Atlantic and their corresponding time evolution. Among all the noise surface fluxes, heat flux plays a major role. The results from simulations using actual observations also suggest that the observed SST variability is mostly atmospheric weather noise forced. The regional atmospheric noise forcing, especially the heat flux noise forcing, is the major source of the low frequency SST variability in the North Atlantic. The observed SST tripole mode has about a 12 year period and it can be reasonably reproduced by the weather noise forcing in terms of its period, spatial pattern and variance. Based on our diagnosis, it is argued that the SST tripole is mainly forced by local atmospheric heat flux noise. The gyre circulation plays a secondary role: the anomalous gyre circulation advects mean thermal features across the inter-gyre boundary, and the mean gyre advection carries SST anomalies along the inter-gyre boundary. The diagnosis is compared with a delayed oscillator theory. We find that the delayed oscillator theory is not supported and that the SST tripole mode is forced by weather noise heat flux noise. However, the result may be model dependent.

The plasma levels of soluble ST2 as a marker of gut mucosal damage in early HIV infection

PubMed Central

Mehraj, Vikram; Jenabian, Mohammad-Ali; Ponte, Rosalie; Lebouché, Bertrand; Costiniuk, Cecilia; Thomas, Réjean; Baril, Jean-Guy; LeBlanc, Roger; Cox, Joseph; Tremblay, Cécile; Routy, Jean-Pierre

2016-01-01

Objective: Following tissue barrier breaches, interleukin-33 (IL-33) is released as an ‘alarmin’ to induce inflammation. Soluble suppression of tumorigenicity 2 (sST2), as an IL-33 decoy receptor, contributes to limit inflammation. We assessed the relationship between the IL-33/ST2 axis and markers of gut mucosal damage in patients with early (EHI) and chronic HIV infection (CHI) and elite controllers. Design: Analyses on patients with EHI and CHI were conducted to determine IL-33/sST2 changes over time. Methods: IL-33 and sST2 levels were measured in plasma. Correlations between sST2 levels and plasma viral load, CD4+ and CD8+ T-cell counts, expression of T-cell activation/exhaustion markers, gut mucosal damage, microbial translocation and inflammation markers, as well as kynurenine/tryptophan ratio were assessed. Results: Plasma sST2 levels were elevated in EHI compared with untreated CHI and uninfected controls, whereas IL-33 levels were comparable in all groups. In EHI, sST2 levels were positively correlated with the CD8+ T-cell count and the percentage of T cells expressing activation and exhaustion markers, but not with viral load or CD4+ T-cell count. Plasma sST2 levels also correlated with plasma levels of gut mucosal damage, microbial translocation and kynurenine/tryptophan ratio and for some markers of inflammation. Prospective analyses showed that early antiretroviral therapy had no impact on sST2 levels, whereas longer treatment duration initiated during CHI normalized sST2. Conclusion: As sST2 levels were elevated in EHI and were correlated with CD8+ T-cell count, immune activation, and microbial translocation, sST2 may serve as a marker of disease progression, gut damage and may directly contribute to HIV pathogenesis. PMID:27045377

How much of the interannual variability of East Asian summer rainfall is forced by SST?

NASA Astrophysics Data System (ADS)

He, Chao; Wu, Bo; Li, Chunhui; Lin, Ailan; Gu, Dejun; Zheng, Bin; Zhou, Tianjun

2016-07-01

It is widely accepted that the interannual variability of East Asian summer rainfall is forced by sea surface temperature (SST), and SST anomalies are widely used as predictors of East Asian summer rainfall. But it is still not very clear what percentage of the interannual rainfall variability is contributed by SST anomalies. In this study, Atmospheric general circulation model simulations forced by observed interannual varying SST are compared with those forced by the fixed annual cycle of SST climatology, and their ratios of interannual variance (IAV) are analyzed. The output of 12 models from the 5th Phase of Coupled Model Intercomparison Project (CMIP5) are adopted, and idealized experiments are done by Community Atmosphere Model version 4 (CAM4). Both the multi-model median of CMIP5 models and CAM4 experiments show that only about 18 % of the IAV of rainfall over East Asian land (EAL) is explained by SST, which is significantly lower than the tropical western Pacific, but comparable to the mid-latitude western Pacific. There is no significant difference between the southern part and the northern part of EAL in the percentages of SST contribution. The remote SST anomalies regulates rainfall over EAL probably by modulating the horizontal water vapor transport rather than the vertical motion, since the horizontal water vapor transport into EAL is strongly modulated by SST but the vertical motion over EAL is not. Previous studies argued about the relative importance of tropical Indian Ocean and tropical Pacific Ocean to East Asian summer rainfall anomalies. Our idealized experiments performed by CAM4 suggest that the contributions from these two ocean basins are comparable to each other, both of which account for approximately 6 % of the total IAV of rainfall over EAL.

Impact of High Resolution SST Data on Regional Weather Forecasts

NASA Technical Reports Server (NTRS)

Jedlovec, Gary J.; Case, Jonathon; LaFontaine, Frank; Vazquez, Jorge; Mattocks, Craig

2010-01-01

Past studies have shown that the use of coarse resolution SST products such as from the real-time global (RTG) SST analysis[1] or other coarse resolution once-a-day products do not properly portray the diurnal variability of fluxes of heat and moisture from the ocean that drive the formation of low level clouds and precipitation over the ocean. For example, the use of high resolution MODIS SST composite [2] to initialize the Advanced Research Weather Research and Forecast (WRF) (ARW) [3] has been shown to improve the prediction of sensible weather parameters in coastal regions [4][5}. In an extend study, [6] compared the MODIS SST composite product to the RTG SST analysis and evaluated forecast differences for a 6 month period from March through August 2007 over the Florida coastal regions. In a comparison to buoy data, they found that that the MODIS SST composites reduced the bias and standard deviation over that of the RTG data. These improvements led to significant changes in the initial and forecasted heat fluxes and the resulting surface temperature fields, wind patterns, and cloud distributions. They also showed that the MODIS composite SST product, produced for the Terra and Aqua satellite overpass times, captured a component of the diurnal cycle in SSTs not represented in the RTG or other one-a-day SST analyses. Failure to properly incorporate these effects in the WRF initialization cycle led to temperature biases in the resulting short term forecasts. The forecast impact was limited in some situations however, due to composite product inaccuracies brought about by data latency during periods of long-term cloud cover. This paper focuses on the forecast impact of an enhanced MODIS/AMSR-E composite SST product designed to reduce inaccuracies due data latency in the MODIS only composite product.

Not So Giants: Mice Lacking Both Somatostatin and Cortistatin Have High GH Levels but Show No Changes in Growth Rate or IGF-1 Levels.

PubMed

Pedraza-Arévalo, S; Córdoba-Chacón, J; Pozo-Salas, A I; L-López, F; de Lecea, L; Gahete, M D; Castaño, J P; Luque, R M

2015-06-01

Somatostatin (SST) and cortistatin (CORT) are two highly related neuropeptides involved in the regulation of various endocrine secretions. In particular, SST and CORT are two primary negative regulators of GH secretion. Consequently, single SST or CORT knockout mice exhibit elevated GH levels; however, this does not lead to increased IGF-1 levels or somatic growth. This apparent lack of correspondence has been suggested to result from compensatory mechanisms between both peptides. To test this hypothesis, in this study we explored, for the first time, the consequences of simultaneously deleting endogenous SST and CORT by generating a double SST/CORT knockout mouse model and exploring its endocrine and metabolic phenotype. Our results demonstrate that simultaneous deletion of SST and CORT induced a drastic elevation of endogenous GH levels, which, surprisingly, did not lead to changes in growth rate or IGF-1 levels, suggesting the existence of additional factors/systems that, in the absence of endogenous SST and CORT, could counteract GH actions. Notably, elevation in circulating GH levels were not accompanied by changes in pituitary GH expression or by alterations in the expression of its main regulators (GHRH and ghrelin) or their receptors (GHRH receptor, GHS receptor, or SST/CORT receptors) at the hypothalamic or pituitary level. However, although double-SST/CORT knockout male mice exhibited normal glucose and insulin levels, they had improved insulin sensitivity compared with the control mice. Therefore, these results suggest the existence of an intricate interplay among the known (SST/CORT), and likely unknown, inhibitory components of the GH/IGF-1 axis to regulate somatic growth and glucose/insulin homeostasis.

Using a Model of Clinical Events to Determine Supply Requirements for Marine Corps Shock Surgical Team/Triage (SST) and Acute Care Ward Units.

DTIC Science & Technology

1998-06-01

Infusion Blood Products • 248 Force Fluids • • 064 Venous Cutdown • 263 Partial Bath (Assisted) • • 065 Insert Central Venous Lines • 267 Linen Change...which are further complicated by inadequate patient histories , diagnostic tools, and logistic support. Timely and appropriate treatment may...Appropriate Medication • 011 Stabilize Cervical • • 148 Obtain Specimen for Lab Analysis • • 017 Suction (Oral/Trach/Endo) • • 149 Blood Drawing Venous

The Use of Neural Networks in Identifying Error Sources in Satellite-Derived Tropical SST Estimates

PubMed Central

Lee, Yung-Hsiang; Ho, Chung-Ru; Su, Feng-Chun; Kuo, Nan-Jung; Cheng, Yu-Hsin

2011-01-01

An neural network model of data mining is used to identify error sources in satellite-derived tropical sea surface temperature (SST) estimates from thermal infrared sensors onboard the Geostationary Operational Environmental Satellite (GOES). By using the Back Propagation Network (BPN) algorithm, it is found that air temperature, relative humidity, and wind speed variation are the major factors causing the errors of GOES SST products in the tropical Pacific. The accuracy of SST estimates is also improved by the model. The root mean square error (RMSE) for the daily SST estimate is reduced from 0.58 K to 0.38 K and mean absolute percentage error (MAPE) is 1.03%. For the hourly mean SST estimate, its RMSE is also reduced from 0.66 K to 0.44 K and the MAPE is 1.3%. PMID:22164030

Analysis of the VIIRS cloud mask, comparison with the NAVOCEANO cloud mask, and how they complement each other

NASA Astrophysics Data System (ADS)

Cayula, Jean-François P.; May, Douglas A.; McKenzie, Bruce D.

2014-05-01

The Visible Infrared Imaging Radiometer Suite (VIIRS) Cloud Mask (VCM) Intermediate Product (IP) has been developed for use with Suomi National Polar-orbiting Partnership (NPP) VIIRS Environmental Data Record (EDR) products. In particular, the VIIRS Sea Surface Temperature (SST) EDR relies on VCM to identify cloud contaminated observations. Unfortunately, VCM does not appear to perform as well as cloud detection algorithms for SST. This may be due to similar but different goals of the two algorithms. VCM is concerned with detecting clouds while SST is interested in identifying clear observations. The result is that in undetermined cases VCM defaults to "clear," while the SST cloud detection defaults to "cloud." This problem is further compounded because classic SST cloud detection often flags as "cloud" all types of corrupted data, thus making a comparison with VCM difficult. The Naval Oceanographic Office (NAVOCEANO), which operationally produces a VIIRS SST product, relies on cloud detection from the NAVOCEANO Cloud Mask (NCM), adapted from cloud detection schemes designed for SST processing. To analyze VCM, the NAVOCEANO SST process was modified to attach the VCM flags to all SST retrievals. Global statistics are computed for both day and night data. The cases where NCM and/or VCM tag data as cloud-contaminated or clear can then be investigated. By analyzing the VCM individual test flags in conjunction with the status of NCM, areas where VCM can complement NCM are identified.

Adaptive synchrosqueezing based on a quilted short-time Fourier transform

NASA Astrophysics Data System (ADS)

Berrian, Alexander; Saito, Naoki

2017-08-01

In recent years, the synchrosqueezing transform (SST) has gained popularity as a method for the analysis of signals that can be broken down into multiple components determined by instantaneous amplitudes and phases. One such version of SST, based on the short-time Fourier transform (STFT), enables the sharpening of instantaneous frequency (IF) information derived from the STFT, as well as the separation of amplitude-phase components corresponding to distinct IF curves. However, this SST is limited by the time-frequency resolution of the underlying window function, and may not resolve signals exhibiting diverse time-frequency behaviors with sufficient accuracy. In this work, we develop a framework for an SST based on a "quilted" short-time Fourier transform (SST-QSTFT), which allows adaptation to signal behavior in separate time-frequency regions through the use of multiple windows. This motivates us to introduce a discrete reassignment frequency formula based on a finite difference of the phase spectrum, ensuring computational accuracy for a wider variety of windows. We develop a theoretical framework for the SST-QSTFT in both the continuous and the discrete settings, and describe an algorithm for the automatic selection of optimal windows depending on the region of interest. Using synthetic data, we demonstrate the superior numerical performance of SST-QSTFT relative to other SST methods in a noisy context. Finally, we apply SST-QSTFT to audio recordings of animal calls to demonstrate the potential of our method for the analysis of real bioacoustic signals.

Psychometric Properties of the Persian Version of the Simple Shoulder Test (SST) Questionnaire.

PubMed

Ebrahimzadeh, Mohammad H; Vahedi, Ehsan; Baradaran, Aslan; Birjandinejad, Ali; Seyyed-Hoseinian, Seyyed-Hadi; Bagheri, Farshid; Kachooei, Amir Reza

2016-10-01

To validate the Persian version of the simple shoulder test in patients with shoulder joint problems. Following Beaton`s guideline, translation and back translation was conducted. We reached to a consensus on the Persian version of SST. To test the face validity in a pilot study, the Persian SST was administered to 20 individuals with shoulder joint conditions. We enrolled 148 consecutive patients with shoulder problem to fill the Persian SST, shoulder specific measure including Oxford shoulder score (OSS) and two general measures including DASH and SF-36. To measure the test-retest reliability, 42 patients were randomly asked to fill the Persian-SST for the second time after one week. Cronbach's alpha coefficient was used to demonstrate internal consistency over the 12 items of Persian-SST. ICC for the total questionnaire was 0.61 showing good and acceptable test-retest reliability. ICC for individual items ranged from 0.32 to 0.79. The total Cronbach's alpha was 0.84 showing good internal consistency over the 12 items of the Persian-SST. Validity testing showed strong correlation between SST and OSS and DASH. The correlation with OSS was positive while with DASH scores was negative. The correlation was also good to strong with all physical and most mental subscales of the SF-36. Correlation coefficient was higher with DASH and OSS in compare to SF-36. Persian version of SST found to be valid and reliable instrument for shoulder joint pain and function assessment in Iranian population.

The Sulfate Transporter SST1 Is Crucial for Symbiotic Nitrogen Fixation in Lotus japonicus Root Nodules

PubMed Central

Krusell, Lene; Krause, Katja; Ott, Thomas; Desbrosses, Guilhem; Krämer, Ute; Sato, Shusei; Nakamura, Yasukazu; Tabata, Satoshi; James, Euan K.; Sandal, Niels; Stougaard, Jens; Kawaguchi, Masayoshi; Miyamoto, Ai; Suganuma, Norio; Udvardi, Michael K.

2005-01-01

Symbiotic nitrogen fixation (SNF) by intracellular rhizobia within legume root nodules requires the exchange of nutrients between host plant cells and their resident bacteria. Little is known at the molecular level about plant transporters that mediate such exchanges. Several mutants of the model legume Lotus japonicus have been identified that develop nodules with metabolic defects that cannot fix nitrogen efficiently and exhibit retarded growth under symbiotic conditions. Map-based cloning of defective genes in two such mutants, sst1-1 and sst1-2 (for symbiotic sulfate transporter), revealed two alleles of the same gene. The gene is expressed in a nodule-specific manner and encodes a protein homologous with eukaryotic sulfate transporters. Full-length cDNA of the gene complemented a yeast mutant defective in sulfate transport. Hence, the gene was named Sst1. The sst1-1 and sst1-2 mutants exhibited normal growth and development under nonsymbiotic growth conditions, a result consistent with the nodule-specific expression of Sst1. Data from a previous proteomic study indicate that SST1 is located on the symbiosome membrane in Lotus nodules. Together, these results suggest that SST1 transports sulfate from the plant cell cytoplasm to the intracellular rhizobia, where the nutrient is essential for protein and cofactor synthesis, including nitrogenase biosynthesis. This work shows the importance of plant sulfate transport in SNF and the specialization of a eukaryotic transporter gene for this purpose. PMID:15805486

Sense or Sensibility?: How Commitment Mediates the Role of Self-Service Technology on Loyalty

NASA Astrophysics Data System (ADS)

Singh, Sangeeta; Olsen, Line Lervik

It has been well documented that employing self-service technology (SST) results in considerable cost savings but few studies have examined its impact on consumers’ behavior. We apply a well-recognized model from the field of services marketing in an SST context. We examine how the established relationships between satisfaction, affective and calculative commitments, and loyalty are affected when the service is provided through a technology interface as opposed to service personnel. We then present two alternative perspectives on the role of SST. The first is based on the predominant assumption that SST is a moderator of the relationship between customer loyalty and its drivers, while the other rests on the assumption that SST is just another context and that its role in affecting customer loyalty is mediated by drivers of loyalty. A cross-sectional study conducted in the banking industry shows that SST does not change everything. The classical model of how customers evaluate services and the predictors of loyalty are replicated in the SST setting. Interestingly, SST does not have a direct influence on loyalty by itself but its effects are mediated by commitment. However, it is the affective commitment that is more important in forming loyalty toward the service provider.

Multiscale mechanical integrity of human supraspinatus tendon in shear after elastin depletion.

PubMed

Fang, Fei; Lake, Spencer P

2016-10-01

Human supraspinatus tendon (SST) exhibits region-specific nonlinear mechanical properties under tension, which have been attributed to its complex multiaxial physiological loading environment. However, the mechanical response and underlying multiscale mechanism regulating SST behavior under other loading scenarios are poorly understood. Furthermore, little is known about the contribution of elastin to tendon mechanics. We hypothesized that (1) SST exhibits region-specific shear mechanical properties, (2) fiber sliding is the predominant mode of local matrix deformation in SST in shear, and (3) elastin helps maintain SST mechanical integrity by facilitating force transfer among collagen fibers. Through the use of biomechanical testing and multiphoton microscopy, we measured the multiscale mechanical behavior of human SST in shear before and after elastase treatment. Three distinct SST regions showed similar stresses and microscale deformation. Collagen fiber reorganization and sliding were physical mechanisms observed as the SST response to shear loading. Measures of microscale deformation were highly variable, likely due to a high degree of extracellular matrix heterogeneity. After elastase treatment, tendon exhibited significantly decreased stresses under shear loading, particularly at low strains. These results show that elastin contributes to tendon mechanics in shear, further complementing our understanding of multiscale tendon structure-function relationships. Copyright © 2016 Elsevier Ltd. All rights reserved.

Testing for Soluble ST2 in Heart Failure Patients: Reliability of a Point of Care Method.

PubMed

Gruson, Damien; Ferracin, Benjamin; Ahn, Sylvie A; Rousseau, Michel F

2017-01-01

Our objective was to determine soluble ST2 (sST2) concentrations in heart failure (HF) patients with a point-of-care (POCT) assay. sST2 levels were measured in 71 HF patients with both POCT and ELISA methods. The concentrations of sST2 were correlated to HF severity and to some established biomarkers of cardiovascular risk. sST2 levels measured with the ASPECT-PLUS POCT method were significantly correlated with the comparison ELISA assay (r = 0.94, p < 0.01) and were related to HF severity. Levels of sST2 measured with the POCT assay were significantly correlated to NT-proBNP (r = 0.57, p < 0.001), BNP (r = 0.75, p < 0.001), Galectin-3 (r = 0.40, p < 0.01) and PTH (1-84) (r = 0.39, p < 0.01). POCT and ELISA methods for sST2 testing were significantly correlated, and our results confirmed also the clinical reliability of the sST2 POCT assay. Furthermore, the POCT method allows a faster delivery of results to physicians.

Mechanistic prediction of fission-gas behavior during in-cell transient heating tests on LWR fuel using the GRASS-SST and FASTGRASS computer codes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rest, J; Gehl, S M

1979-01-01

GRASS-SST and FASTGRASS are mechanistic computer codes for predicting fission-gas behavior in UO/sub 2/-base fuels during steady-state and transient conditions. FASTGRASS was developed in order to satisfy the need for a fast-running alternative to GRASS-SST. Althrough based on GRASS-SST, FASTGRASS is approximately an order of magnitude quicker in execution. The GRASS-SST transient analysis has evolved through comparisons of code predictions with the fission-gas release and physical phenomena that occur during reactor operation and transient direct-electrical-heating (DEH) testing of irradiated light-water reactor fuel. The FASTGRASS calculational procedure is described in this paper, along with models of key physical processes included inmore » both FASTGRASS and GRASS-SST. Predictions of fission-gas release obtained from GRASS-SST and FASTGRASS analyses are compared with experimental observations from a series of DEH tests. The major conclusions is that the computer codes should include an improved model for the evolution of the grain-edge porosity.« less

The influence of tide on sea surface temperature in the marginal sea of northwest Pacific Ocean

NASA Astrophysics Data System (ADS)

Huang, Shih-Jen; Tsai, Yun-Chan; Ho, Chung-Ru; Lo, Yao-Tsai; Kuo, Nan-Jung

2017-10-01

Tide gauge data provided by the University of Hawaii Sea Level Center and daily sea surface temperature (SST) data from the Moderate Resolution Imaging Spectroradiometer (MODIS) product are used in this study to analyze the influence of tide on the SST in the seas of Northwestern Pacific. In the marginal region, the climatology SST is lower in the northwestern area than that in the southeastern area. In the coastal region, the SST at spring tide is higher than that at neap tide in winter, but it is lower in other seasons. In the adjacent waters of East China Sea and Yellow Sea, the SST at spring tide is higher than that at neap tide in winter and summer but it is lower in spring and autumn. In the open ocean region, the SST at spring tide is higher than that at neap tide in winter, but it is lower in other seasons. In conclusion, not only the river discharge and topography, but also tides could influence the SST variations, especially in the open ocean region.

Role of subsurface ocean in decadal climate predictability over the South Atlantic.

PubMed

Morioka, Yushi; Doi, Takeshi; Storto, Andrea; Masina, Simona; Behera, Swadhin K

2018-06-04

Decadal climate predictability in the South Atlantic is explored by performing reforecast experiments using a coupled general circulation model with two initialization schemes; one is assimilated with observed sea surface temperature (SST) only, and the other is additionally assimilated with observed subsurface ocean temperature and salinity. The South Atlantic is known to undergo decadal variability exhibiting a meridional dipole of SST anomalies through variations in the subtropical high and ocean heat transport. Decadal reforecast experiments in which only the model SST is initialized with the observation do not predict well the observed decadal SST variability in the South Atlantic, while the other experiments in which the model SST and subsurface ocean are initialized with the observation skillfully predict the observed decadal SST variability, particularly in the Southeast Atlantic. In-depth analysis of upper-ocean heat content reveals that a significant improvement of zonal heat transport in the Southeast Atlantic leads to skillful prediction of decadal SST variability there. These results demonstrate potential roles of subsurface ocean assimilation in the skillful prediction of decadal climate variability over the South Atlantic.

No inter-gyre pathway for sea-surface temperature anomalies in the North Atlantic.

PubMed

Foukal, Nicholas P; Lozier, M Susan

2016-04-22

Recent Lagrangian analyses of surface drifters have questioned the existence of a surface current connecting the Gulf Stream (GS) to the subpolar gyre (SPG) and have cast doubt on the mechanism underlying an apparent pathway for sea-surface temperature (SST) anomalies between the two regions. Here we use modelled Lagrangian trajectories to determine the fate of surface GS water and satellite SST data to analyse pathways of GS SST anomalies. Our results show that only a small fraction of the surface GS water reaches the SPG, the water that does so mainly travels below the surface mixed layer, and GS SST anomalies do not propagate into the SPG on interannual timescales. Instead, the inter-gyre heat transport as part of the Atlantic Meridional Overturning Circulation must be accomplished via subsurface pathways. We conclude that the SST in the SPG cannot be predicted by tracking SST anomalies along the GS.

Comparison of children with autism spectrum disorder with and without schizophrenia spectrum traits: gender, season of birth, and mental health risk factors.

PubMed

Gadow, Kenneth D; DeVincent, Carla J

2012-11-01

Children with autism spectrum disorder (ASD) with and without co-occurring schizophrenia spectrum traits (SST) were examined for differences in co-occurring psychiatric symptoms, background characteristics, and mental health risk factors. Participating mothers and teachers completed a DSM-IV-referenced rating scale and a background questionnaire (mothers only) describing 147 children (6-12 years) with ASD. There was a clear pattern of group differences in co-occurring psychiatric symptom severity (+SST > SST-) and background characteristics. Children with impairing SST had more mental health risk factors. Girls were more likely to be classified SST according to mothers' ratings. Children born in spring-summer were more likely to be classified non-SST by teachers' ratings. Findings provide tentative evidence that SST may be a useful marker of behavioral heterogeneity within the ASD clinical phenotype.

Effect of Radiative Cooling on Cloud-SST Relationship within the Tropical Pacific Region

NASA Technical Reports Server (NTRS)

Sui, Chung-Hsiung; Ho, Chang-Hoi; Chou, Ming-Dah; Lau, Ka-Ming; Li, Xiao-Fan; Einaudi, Franco (Technical Monitor)

2000-01-01

A recent analysis found a negative correlation between the area-mean cloud amount and the corresponding mean Sea Surface Temperature (SST) within the cloudy areas. The SST-cloud relation becomes more evident when the SST contrast between warm pool and surrounding cold pool (DSST) in the tropical Pacific is stronger than normal. The above feature is related to the finding that the strength of subsidence over the cold pool is limited by radiative cooling because of its small variability. As a result, the area of radiatively-driven subsidence must expand in response to enhanced low-boundary forcing due to SST warming or enhanced basin-scale DSST. This leads to more cloud free regions and less cloudy regions. The increased ratio of cloud-free areas to cloudy areas leads to more high SST areas (>29.50C) due to enhanced solar radiation.

No inter-gyre pathway for sea-surface temperature anomalies in the North Atlantic

PubMed Central

Foukal, Nicholas P.; Lozier, M. Susan

2016-01-01

Recent Lagrangian analyses of surface drifters have questioned the existence of a surface current connecting the Gulf Stream (GS) to the subpolar gyre (SPG) and have cast doubt on the mechanism underlying an apparent pathway for sea-surface temperature (SST) anomalies between the two regions. Here we use modelled Lagrangian trajectories to determine the fate of surface GS water and satellite SST data to analyse pathways of GS SST anomalies. Our results show that only a small fraction of the surface GS water reaches the SPG, the water that does so mainly travels below the surface mixed layer, and GS SST anomalies do not propagate into the SPG on interannual timescales. Instead, the inter-gyre heat transport as part of the Atlantic Meridional Overturning Circulation must be accomplished via subsurface pathways. We conclude that the SST in the SPG cannot be predicted by tracking SST anomalies along the GS. PMID:27103496

Engineering assessment of low-level liquid waste disposal caisson locations at the 618-11 Burial Grounds

DOE Office of Scientific and Technical Information (OSTI.GOV)

Phillips, S.J.; Fischer, D.D.; Crawford, R.C.

1982-06-01

Rockwell Hanford Operations is currently involved in an extensive effort to perform interim ground surface stabilization activities at retired low-level waste burial grounds located at the Hanford Site, Richland, Washington. The principal objective of these activities is to promote increased occupational and radiological safety at burial grounds. Interim stabilization activities include: (1) load testing (traversing burial ground surfaces with heavy equipment to promote incipient collapse of void spaces within the disposal structure and overburden), (2) barrier placement (placement of a {ge} 0.6 m soil barrier over existing overburden), and (3) revegetation (establishment of shallow rooted vegetation on the barrier tomore » mitigate deep rooted plant growth and to reduce erosion). Low-level waste disposal caissons were used in 300 Area Burial Grounds as internment structures for containerized liquid wastes. These caissons, by virtue of their contents, design and methods of closure, require long-term performance evaluation. As an initial activity to evaluate long-term performance, the accurate location of these structures is required. This topical report summarizes engineering activities used to locate caissons in the subsurface environment at the Burial Ground. Activities were conducted to locate caissons during surface stabilization activities. The surface locations were marked, photographed, and recorded on an as built engineering drawing. The recorded location of these caissons will augment long-term observations of confinement structure and engineered surface barrier performance. In addition, accurate caisson location will minimize occupational risk during monitoring and observation activities periodically conducted at the burial ground.« less

Effects of the neuroprotective drugs somatostatin and brimonidine on retinal cell models of diabetic retinopathy.

PubMed

Beltramo, Elena; Lopatina, Tatiana; Mazzeo, Aurora; Arroba, Ana I; Valverde, Angela M; Hernández, Cristina; Simó, Rafael; Porta, Massimo

2016-12-01

Diabetic retinopathy is considered a microvascular disease, but recent evidence has underlined early involvement of the neuroretina with interactions between microvascular and neural alterations. Topical administration of somatostatin (SST), a neuroprotective molecule with antiangiogenic properties, prevents diabetes-induced retinal neurodegeneration in animals. The α 2 -adrenergic receptor agonist brimonidine (BRM) decreases vitreoretinal vascular endothelial growth factor and inhibits blood-retinal barrier breakdown in diabetic rats. However, SST and BRM effects on microvascular cells have not yet been studied. We investigated the behaviour of these drugs on the crosstalk between microvasculature and neuroretina. Expression of SST receptors 1-5 in human retinal pericytes (HRP) was checked. We subsequently evaluated the effects of diabetic-like conditions (high glucose and/or hypoxia) with/without SST/BRM on HRP survival. Endothelial cells (EC) and photoreceptors were maintained in the above conditions and their conditioned media (CM) used to culture HRP. Vice versa, HRP-CM was used on EC and photoreceptors. Survival parameters were assessed. HRP express the SST receptor 1 (SSTR1). Glucose fluctuations mimicking those occurring in diabetic subjects are more damaging for pericytes and photoreceptors than stable high glucose and hypoxic conditions. SST/BRM added to HRP in diabetic-like conditions decrease EC apoptosis. However, neither SST nor BRM changed the response of pericytes and neuroretina-vascular crosstalk under diabetic-like conditions. Retinal pericytes express SSTR1, indicating that they can be a target for SST. Exposure to SST/BRM had no adverse effects, direct or mediated by the neuroretina, suggesting that these molecules could be safely evaluated for the treatment of ocular diseases.

Impacts of SST Patterns on Rapid Intensification of Typhoon Megi (2010)

NASA Astrophysics Data System (ADS)

Kanada, Sachie; Tsujino, Satoki; Aiki, Hidenori; Yoshioka, Mayumi K.; Miyazawa, Yasumasa; Tsuboki, Kazuhisa; Takayabu, Izuru

2017-12-01

Typhoon Megi (2010), a very intense tropical cyclone with a minimum central pressure of 885 hPa, was characterized by especially rapid intensification. We investigated this intensification process by a simulation experiment using a high-resolution (0.02° × 0.02°) three-dimensional atmosphere-ocean coupled regional model. We also performed a sensitivity experiment with a time-fixed sea surface temperature (SST). The coupled model successfully simulated the minimum central pressure of Typhoon Megi, whereas the fixed SST experiment simulated an excessively low minimum central pressure of 839 hPa. The simulation results also showed a close relationship between the radial SST profiles and the rapid intensification process. Because the warm sea increased near-surface water vapor and hence the convective available potential energy, the high SST in the eye region facilitated tall and intense updrafts inside the radius of maximum wind speed and led to the start of rapid intensification. In contrast, high SST outside this radius induced local secondary updrafts that inhibited rapid intensification even if the mean SST in the core region exceeded 29.0°C. These secondary updrafts moved inward and eventually merged with the primary eyewall updrafts. Then the storm intensified rapidly when the high SST appeared in the eye region. Thus, the changes in the local SST pattern around the storm center strongly affected the rapid intensification process by modulating the radial structure of core convection. Our results also show that the use of a high-resolution three-dimensional atmosphere-ocean coupled model offers promise for improving intensity forecasts of tropical cyclones.

Modulating Effects of Mesoscale Oceanic Eddies on Sea Surface Temperature Response to Tropical Cyclones Over the Western North Pacific

NASA Astrophysics Data System (ADS)

Ma, Zhanhong; Fei, Jianfang; Huang, Xiaogang; Cheng, Xiaoping

2018-01-01

The impact of mesoscale oceanic eddies on the temporal and spatial characteristics of sea surface temperature (SST) response to tropical cyclones is investigated in this study based on composite analysis of cyclone-eddy interactions over the western North Pacific. The occurrence times of maximum cooling, recovery time, and spatial patterns of SST response are specially evaluated. The influence of cold-core eddies (CCEs) renders the mean occurrence time of maximum SST cooling to become about half a day longer than that in eddy-free condition, while warm-core eddies (WCEs) have little effect on this facet. The recovery time of SST cooling also takes longer in presence of CCEs, being overall more pronounced for stronger or slower tropical cyclones. The effect of WCEs on the recovery time is again not significant. The modulation of maximum SST decrease by WCEs for category 2-5 storms is found to be remarkable in the subtropical region but not evident in the tropical region, while the role of CCEs is remarkable in both regions. The CCEs are observed to change the spatial characteristics of SST response, with enhanced SST decrease initially at the right side of storm track. During the recovery period the strengthened SST cooling by CCEs propagates leftward gradually, with a feature similar as both the westward-propagating eddies and the recovery of cold wake. These results underscore the importance of resolving mesoscale oceanic eddies in coupled numerical models to improve the prediction of storm-induced SST response.

Biweekly Sea Surface Temperature over the South China Sea and its association with the Western North Pacific Summer Monsoon

NASA Astrophysics Data System (ADS)

Vaid, B. H.

2017-02-01

The association of the biweekly intraseasonal (BWI) oscillation in the Sea Surface Temperature (SST) over the South China Sea (SCS) and the Western North Pacific Summer Monsoon is authenticated using version 4 the Tropical Rainfall Measuring Mission Microwave Imager data (SST and rain) and heat fluxes from Ocean Atmosphere Flux project data during 1998-2012. The results suggest that the SCS involves ocean-atmosphere coupling on biweekly timescales. The positive biweekly SST anomalies lead the rain anomalies over the SCS by 3 days, with a significant correlation coefficient ( r = 0.6, at 99 % significance levels) between the SST-rain anomalies. It is evident from lead/lag correlation between biweekly SST and zonal wind shear that warm ocean surface induced by wind shear may contribute to a favorable condition of the convective activity over the SCS. The present study suggests that ocean-to-atmospheric processes induced by the BWI oscillation in the SCS SST results in enhanced sea level pressure and surface shortwave radiation flux during the summer monsoon. Besides, it is observed that the SCS BWI oscillation in the changes of SST causes a feedback in the atmosphere by modifying the atmospheric instability. This suggests that the active/break biweekly cycle of the SST over the SCS is related by sea level pressure, surface heat fluxes and atmospheric instability. The potential findings here indicate that the biweekly SST over the SCS play an important role in the eastward and the southward propagation of the biweekly anomalies in the Western North Pacific.

Simulation of Rainfall Variability Over West Africa

NASA Astrophysics Data System (ADS)

Bader, J.; Latif, M.

The impact of sea surface temperature (SST) and vegetation on precipitation over West Africa is investigated with the atmospheric general circulation model ECHAM4.x/T42. Ensemble experiments -driven with observed SST- show that At- lantic SST has a significant influence on JJA precipitation over West Africa. Four- teen experiments were performed in which the climatological SST was enhanced or decreased by one Kelvin in certain ocean areas. Changing SST in the eastern tropi- cal Atlantic only caused significant changes along the Guinea Coast, with a positive SSTA increasing rainfall and a negative reducing it. The response was nearly linear. Changing SST in other ocean areas caused significant changes over West Africa, es- pecially in the Sahel area. The response is found to be non linear, with only negative SSTA leading to significant reduction in Sahel rainfall. Also, the impact of the SSTAs from the different ocean regions was not additive with respect to the rainfall. Four simulations with a coupled model (the simple dynamic vegetation model (SVege) and the ECHAM4-AGCM were coupled) were also performed, driven with observed SST from 1945 to 1998. The standard ECHAM-AGCM -forced by the same observed SST- was able to reproduce the drying trend from the fifties to the mid-eighties in the Sahel, but failed to mirror the magnitude of the rainfall anomalies. The coupled model was not only able to reproduce this drying trend, but was also able to better reproduce the amplitudes of the rainfall anomalies. The dynamic vegetation acted like an amplifier, increasing the SST induced rainfall anomalies.

Remote SST Forcing and Local Land-Atmosphere Moisture Coupling as Drivers of Amazon Temperature and Carbon Cycle Variability

NASA Astrophysics Data System (ADS)

Levine, P. A.; Xu, M.; Chen, Y.; Randerson, J. T.; Hoffman, F. M.

2017-12-01

Interannual variability of climatic conditions in the Amazon rainforest is associated with El Niño-Southern Oscillation (ENSO) and ocean-atmosphere interactions in the North Atlantic. Sea surface temperature (SST) anomalies in these remote ocean regions drive teleconnections with Amazonian surface air temperature (T), precipitation (P), and net ecosystem production (NEP). While SST-driven NEP anomalies have been primarily linked to T anomalies, it is unclear how much the T anomalies result directly from SST forcing of atmospheric circulation, and how much result indirectly from decreases in precipitation that, in turn, influence surface energy fluxes. Interannual variability of P associated with SST anomalies lead to variability in soil moisture (SM), which would indirectly affect T via partitioning of turbulent heat fluxes between the land surface and the atmosphere. To separate the direct and indirect influence of the SST signal on T and NEP, we performed a mechanism-denial experiment to decouple SST and SM anomalies. We used the Accelerated Climate Modeling for Energy (ACMEv0.3), with version 5 of the Community Atmosphere Model and version 4.5 of the Community Land Model. We forced the model with observed SSTs from 1982-2016. We found that SST and SM variability both contribute to T and NEP anomalies in the Amazon, with relative contributions depending on lag time and location within the Amazon basin. SST anomalies associated with ENSO drive most of the T variability at shorter lag times, while the ENSO-driven SM anomalies contribute more to T variability at longer lag times. SM variability and the resulting influence on T anomalies are much stronger in the eastern Amazon than in the west. Comparing modeled T with observations demonstrate that SST alone is sufficient for simulating the correct timing of T variability, but SM anomalies are necessary for simulating the correct magnitude of the T variability. Modeled NEP indicated that variability in carbon fluxes results from both SST and SM anomalies. As with T, SM anomalies affect NEP at a much longer lag time than SST anomalies. These results highlight the role of land-atmosphere coupling in driving climate variability within the Amazon, and suggest that land atmospheric coupling may amplify and delay carbon cycle responses to ocean-atmosphere teleconnections.

DOTA-Derivatives of Octreotide Dicarba-Analogs with High Affinity for Somatostatin sst2,5 Receptors.

PubMed

Pratesi, Alessandro; Ginanneschi, Mauro; Lumini, Marco; Papini, Anna M; Novellino, Ettore; Brancaccio, Diego; Carotenuto, Alfonso

2017-01-01

In vivo somatostatin receptor scintigraphy is a valuable method for the visualization of human endocrine tumors and their metastases. In fact, peptide ligands of somatostatin receptors (sst's) conjugated with chelating agents are in clinical use. We have recently developed octreotide dicarba-analogs, which show interesting binding profiles at sst's. In this context, it was mandatory to explore the possibility that our analogs could maintain their activity also upon conjugation with DOTA. In this paper, we report and discuss the synthesis, binding affinity and conformational preferences of three DOTA-conjugated dicarba-analogs of octreotide. Interestingly, two conjugated analogs exhibited nanomolar affinities on sst 2 and sst 5 somatostatin receptor subtypes.

A radiative transfer model for sea surface temperature retrieval for the along-track scanning radiometer

NASA Astrophysics Data System (ADS)

ZáVody, A. M.; Mutlow, C. T.; Llewellyn-Jones, D. T.

1995-01-01

The measurements made by the along-track scanning radiometer are now converted routinely into sea surface temperature (SST). The details of the atmospheric model which had been used for deriving the SST algorithms are given, together with tables of the coefficients in the algorithms for the different SST products. The accuracy of the retrieval under normal conditions and the effect of errors in the model on the retrieved SST are briefly discussed.

Interannual variability in stratiform cloudiness and sea surface temperature

NASA Technical Reports Server (NTRS)

Norris, Joel R.; Leovy, Conway B.

1994-01-01

Marine stratiform cloudiness (MSC)(stratus, stratocumulus, and fog) is widespread over subtropical oceans west of the continents and over midlatitude oceans during summer, the season when MSC has maximum influence on surface downward radiation and is most influenced by boundary-layer processes. Long-term datasets of cloudiness and sea surface teperature (SST) from surface observations from 1952 to 1981 are used to examine interannual variations in MSC and SST. Linear correlations of anomalies in seasonal MSC amount with seasonal SST anomalies are negative and significant in midlatitude and eastern subtropical oceans, especially during summer. Significant negative correlations between SST and nimbostratus and nonprecipitating midlevel cloudiness are also observed at midlatitudes during summer, suggesting that summer storm tracks shift from year to year following year-to-year meridional shifts in the SST gradient. Over the 30-yr period, there are significant upward trends in MSC amount over the northern midlatitude oceans and a significant downward trend off the coast of California. The highest correlations and trends occur where gradients in MSC and SST are strongest. During summer, correlations between SST and MSC anomalies peak at zero lag in midlatitudes where warm advection prevails, but SST lags MSC in subtropical regions where cold advection predominates. This difference is attributed to a tendency for anomalies in latent heat flux to compensate anomalies in surface downward radiation in warm advection regions but not in cold advection regions.

Hurricane destructive power predictions based on historical storm and sea surface temperature data.

PubMed

Bogen, Kenneth T; Jones, Edwin D; Fischer, Larry E

2007-12-01

Forecasting destructive hurricane potential is complicated by substantial, unexplained intraannual variation in storm-specific power dissipation index (PDI, or integrated third power of wind speed), and interannual variation in annual accumulated PDI (APDI). A growing controversy concerns the recent hypothesis that the clearly positive trend in North Atlantic Ocean (NAO) sea surface temperature (SST) since 1970 explains increased hurricane intensities over this period, and so implies ominous PDI and APDI growth as global warming continues. To test this "SST hypothesis" and examine its quantitative implications, a combination of statistical and probabilistic methods were applied to National Hurricane Center HURDAT best-track data on NAO hurricanes during 1880-2002, and corresponding National Oceanographic and Atmospheric Administration Extended Reconstruction SST estimates. Notably, hurricane behavior was compared to corresponding hurricane-specific (i.e., spatiotemporally linked) SST; previous similar comparisons considered only SST averaged over large NAO regions. Contrary to the SST hypothesis, SST was found to vary in a monthly pattern inconsistent with that of corresponding PDI, and to be at best weakly associated with PDI or APDI despite strong correlation with corresponding mean latitude (R(2)= 0.55) or with combined mean location and a approximately 90-year periodic trend (R(2)= 0.70). Over the last century, the lower 75% of APDIs appear randomly sampled from a nearly uniform distribution, and the upper 25% of APDIs from a nearly lognormal distribution. From the latter distribution, a baseline (SST-independent) stochastic model was derived predicting that over the next half century, APDI will not likely exceed its maximum value over the last half century by more than a factor of 1.5. This factor increased to 2 using a baseline model modified to assume SST-dependence conditioned on an upper bound of the increasing NAO SST trend observed since 1970. An additional model was developed that predicts PDI statistics conditional on APDI. These PDI and APDI models can be used to estimate upper bounds on indices of hurricane power likely to be realized over the next century, under divergent assumptions regarding SST influence.

The integrated value of sST2 and global longitudinal strain in the early stratification of patients with severe aortic valve stenosis: a translational imaging approach.

PubMed

Fabiani, Iacopo; Conte, Lorenzo; Pugliese, Nicola Riccardo; Calogero, Enrico; Barletta, Valentina; Di Stefano, Rossella; Santoni, Tatiana; Scatena, Cristian; Bortolotti, Uberto; Naccarato, Antonio Giuseppe; Petronio, Anna Sonia; Di Bello, Vitantonio

2017-12-01

Aortic valve stenosis (AVS) is associated with significant myocardial fibrosis (MF). Global longitudinal strain (GLS) is a sensible indicator of systolic dysfunction. ST2 is a member of the interleukin (IL)-1 receptor family and a modulator of hypertrophic and fibrotic responses. We aimed at assessing: (a) the association between adverse LV remodeling, LV functional parameters (including GLS) and sST2 level. (b) The association between MF (detected by endo-myocardial biopsy) and sST2 in patients with AVS undergoing surgical valve replacement. Twenty-two patients with severe AVS and preserved EF underwent aortic valve replacement. They performed laboratory analysis, including serum ST2 (sST2), echocardiography and inter-ventricular septum biopsy to assess MF (%). We included ten controls for comparison. Compared to controls, patients showed higher sST2 levels (p < 0.0001). sST2 showed correlation with Age (r = 0.58; p = 0.0004), E/e' average (r = 0.58; p = 0.0007), GLS (r = 0.61; p = 0.0002), LAVi (r = 0.51; p = 0.003), LVMi (r = 0.43; p = 0.01), sPAP (r = 0.36; p = 0.04) and SVi (r = -0.47; p < 0.005). No correlation was found between MF and sST2. At ROC analysis, a sST2 ≥ 284 ng/mL had the best accuracy to discriminate controls from patients with impaired GLS, i.e. GLS ≤ 17% (AUC 0.80; p = 0.003; sensitivity 95%; specificity 83%) and increased E/e' average (AUC 0.87; p = 0.0001; sensitivity 96%; specificity 74%). At multivariate regression analysis GLS resulted the only independent predictor of sST2 levels (R 2  = 0.35; p =  0.0004). Patients with severe AVS present elevated sST2 levels. LV GLS resulted the only independent predictor of sST2 levels.

Estimates of Single Sensor Error Statistics for the MODIS Matchup Database Using Machine Learning

NASA Astrophysics Data System (ADS)

Kumar, C.; Podesta, G. P.; Minnett, P. J.; Kilpatrick, K. A.

2017-12-01

Sea surface temperature (SST) is a fundamental quantity for understanding weather and climate dynamics. Although sensors aboard satellites provide global and repeated SST coverage, a characterization of SST precision and bias is necessary for determining the suitability of SST retrievals in various applications. Guidance on how to derive meaningful error estimates is still being developed. Previous methods estimated retrieval uncertainty based on geophysical factors, e.g. season or "wet" and "dry" atmospheres, but the discrete nature of these bins led to spatial discontinuities in SST maps. Recently, a new approach clustered retrievals based on the terms (excluding offset) in the statistical algorithm used to estimate SST. This approach resulted in over 600 clusters - too many to understand the geophysical conditions that influence retrieval error. Using MODIS and buoy SST matchups (2002 - 2016), we use machine learning algorithms (recursive and conditional trees, random forests) to gain insight into geophysical conditions leading to the different signs and magnitudes of MODIS SST residuals (satellite SSTs minus buoy SSTs). MODIS retrievals were first split into three categories: < -0.4 C, -0.4 C ≤ residual ≤ 0.4 C, and > 0.4 C. These categories are heavily unbalanced, with residuals > 0.4 C being much less frequent. Performance of classification algorithms is affected by imbalance, thus we tested various rebalancing algorithms (oversampling, undersampling, combinations of the two). We consider multiple features for the decision tree algorithms: regressors from the MODIS SST algorithm, proxies for temperature deficit, and spatial homogeneity of brightness temperatures (BTs), e.g., the range of 11 μm BTs inside a 25 km2 area centered on the buoy location. These features and a rebalancing of classes led to an 81.9% accuracy when classifying SST retrievals into the < -0.4 C and -0.4 C ≤ residual ≤ 0.4 C categories. Spatial homogeneity in BTs consistently appears as a very important variable for classification, suggesting that unidentified cloud contamination still is one of the causes leading to negative SST residuals. Precision and accuracy of error estimates from our decision tree classifier are enhanced using this knowledge.

Assessing the Contribution of Sea Surface Temperature and Salinity to Coral δ18O using a Weighted Forward Model

NASA Astrophysics Data System (ADS)

Horlick, K. A.; Thompson, D. M.; Anderson, D. M.

2015-12-01

The isotopic ratio of 16O/18O (δ18O) in coral carbonate skeletons is a robust, high-resolution proxy for sea surface temperature (SST) and sea surface salinity (SSS) variability predating the instrumental record. Although SST and δ18O-water (correlated to SSS) variability both contribute to the δ18O signal in the coral carbonate archive, the paucity and limited temporal span of SST and SSS instrumental observations limit the ability to differentiate respective SST and SSS contribution to each δ18O record. From instrumental datasets such as HadISST v.3, ERSST, SODA, and Delcroix (2011), we forward model the δ18O ("pseudoproxy") signal using the linear bivariate forward model from Thompson 2011 ("pseudoproxy"= a1(SST)+a2(SSS)). By iteratively weighting (between 0 and 1 by 0.005) the relative contribution of SST and SSS terms to the δ18O "pseudoproxy" following Gorman et al. 2012 method, we derive the percent contributions of SST and SSS to δ18O at each site based on the weights that produce the optimal correlation to the observed coral δ18O signal. A Monte Carlo analysis of error propagation in the weighted and unweighted pseudoproxy time series was used to determine how well the weighted and unweighted forward models captured observed δ18O variance. Across the south-western Pacific (40 sites) we found that SST contributes from less than 8 to more than 78% of the variance. This work builds upon this simple forward model of coral δ18O and improves our understanding of potential sources of differences in the observed and forward modeled δ18O variability. These results may also improve SST and SSS reconstructions from corals by highlighting the reef areas whose coral δ18O signal is most heavily influenced by SST and SSS respectively. Using an inverse approach, creating a transfer function, local SST and SSS could also be reconstructed based on the site-specific weights and observed coral δ18O time series.

Dutch Perspective on Coastal Louisiana Flood Risk Reduction and Landscape Stabilization

DTIC Science & Technology

2007-04-01

man-made conditions. In the Netherlands, these interventions span ages dating back to roughly the 23 April, 2007 First Interim Report Dutch...Dutch Case (see below). Doing the right thing after 1953 was based on ages of thinking and acting to cultivate the Delta, to store fresh water and to...through the ages developed to its present state through reclamation of marshlands, increasing water management technologies and through response

The seasonal cycle of low stratiform clouds

NASA Technical Reports Server (NTRS)

Klein, Stephen A.; Hartmann, Dennis L.

1993-01-01

The seasonal cycle of low stratiform clouds is studied using data from surface-based cloud climatologies. The impact of low clouds on the radiation budget is illustrated by comparison of data from the Earth Radiation Budget Experiment with the cloud climatologies. Ten regions of active stratocumulus convection are identified. These regions fall into four categories: subtropical marine, midlatitude marine, Arctic stratus, and Chinese stratus. With the exception of the Chinese region, all the regions with high amounts of stratus clouds are over the oceans. In all regions except the Arctic, the season of maximum stratus corresponds to the season of greatest lower-troposphere static stability. Interannual variations in stratus cloud amount also are related to changes in static stability. A linear analysis indicates that a 6 percent increase in stratus fractional area coverage is associated with each 1 C increase in static stability. Over midlatitude oceans, sky-obscuring fog is a large component of the summertime stratus amount. The amount of fog appears to be related to warm advection across sharp gradients of SST.

The Seasonal Cycle of Low Stratiform Clouds.

NASA Astrophysics Data System (ADS)

Klein, Stephen A.; Hartmann, Dennis L.

1993-08-01

The seasonal cycle of low stratiform clouds is studied using data from surface-based cloud climatologies. The impact of low clouds on the radiation budget is illustrated by comparison of data from the Earth Radiation Budget Experiment with the cloud climatologies. Ten regions of active stratocumulus convection are identified. These regions fall into four categories: subtropical marine, midlatitude marine, Arctic stratus, and Chinese stratus. With the exception of the Chinese region, all the regions with high amounts of stratus clouds are over the oceans.In all regions except the Arctic, the season of maximum stratus corresponds to the season of greatest lower-troposphere static stability. Interannual variations in stratus cloud amount also are related to changes in static stability. A linear analysis indicates that a 6% increase in stratus fractional area coverage is associated with each 1°C increase in static stability. Over midlatitude oceans, sky-obscuring fog is a large component of the summertime stratus amount. The amount of fog appears to be related to warm advection across sharp gradients of SST.

Theoretical Advances in Sequential Data Assimilation for the Atmosphere and Oceans

NASA Astrophysics Data System (ADS)

Ghil, M.

2007-05-01

We concentrate here on two aspects of advanced Kalman--filter-related methods: (i) the stability of the forecast- assimilation cycle, and (ii) parameter estimation for the coupled ocean-atmosphere system. The nonlinear stability of a prediction-assimilation system guarantees the uniqueness of the sequentially estimated solutions in the presence of partial and inaccurate observations, distributed in space and time; this stability is shown to be a necessary condition for the convergence of the state estimates to the true evolution of the turbulent flow. The stability properties of the governing nonlinear equations and of several data assimilation systems are studied by computing the spectrum of the associated Lyapunov exponents. These ideas are applied to a simple and an intermediate model of atmospheric variability and we show that the degree of stabilization depends on the type and distribution of the observations, as well as on the data assimilation method. These results represent joint work with A. Carrassi, A. Trevisan and F. Uboldi. Much is known by now about the main physical mechanisms that give rise to and modulate the El-Nino/Southern- Oscillation (ENSO), but the values of several parameters that enter these mechanisms are an important unknown. We apply Extended Kalman Filtering (EKF) for both model state and parameter estimation in an intermediate, nonlinear, coupled ocean-atmosphere model of ENSO. Model behavior is very sensitive to two key parameters: (a) "mu", the ocean-atmosphere coupling coefficient between the sea-surface temperature (SST) and wind stress anomalies; and (b) "delta-s", the surface-layer coefficient. Previous work has shown that "delta- s" determines the period of the model's self-sustained oscillation, while "mu' measures the degree of nonlinearity. Depending on the values of these parameters, the spatio-temporal pattern of model solutions is either that of a delayed oscillator or of a westward propagating mode. Assimilation of SST data from the NCEP- NCAR Reanalysis-2 shows that the parameters can vary on fairly short time scales and switch between values that approximate the two distinct modes of ENSO behavior. Rapid adjustments of these parameters occur, in particular, during strong ENSO events. Ways to apply EKF parameter estimation efficiently to state-of-the-art coupled ocean-atmosphere GCMs will be discussed. These results arise from joint work with D. Kondrashov and C.-j. Sun.

A Simple Technique for Creating Regional Composites of Sea Surface Temperature from MODIS for Use in Operational Mesoscale NWP

NASA Technical Reports Server (NTRS)

Knievel, Jason C.; Rife, Daran L.; Grim, Joseph A.; Hahmann, Andrea N.; Hacker, Joshua P.; Ge, Ming; Fisher, Henry H.

2010-01-01

This paper describes a simple technique for creating regional, high-resolution, daytime and nighttime composites of sea surface temperature (SST) for use in operational numerical weather prediction (NWP). The composites are based on observations from NASA s Moderate Resolution Imaging Spectroradiometer (MODIS) aboard Aqua and Terra. The data used typically are available nearly in real time, are applicable anywhere on the globe, and are capable of roughly representing the diurnal cycle in SST. The composites resolution is much higher than that of many other standard SST products used for operational NWP, including the low- and high-resolution Real-Time Global (RTG) analyses. The difference in resolution is key because several studies have shown that highly resolved SSTs are important for driving the air sea interactions that shape patterns of static stability, vertical and horizontal wind shear, and divergence in the planetary boundary layer. The MODIS-based composites are compared to in situ observations from buoys and other platforms operated by the National Data Buoy Center (NDBC) off the coasts of New England, the mid-Atlantic, and Florida. Mean differences, mean absolute differences, and root-mean-square differences between the composites and the NDBC observations are all within tenths of a degree of those calculated between RTG analyses and the NDBC observations. This is true whether or not one accounts for the mean offset between the skin temperatures of the MODIS dataset and the bulk temperatures of the NDBC observations and RTG analyses. Near the coast, the MODIS-based composites tend to agree more with NDBC observations than do the RTG analyses. The opposite is true away from the coast. All of these differences in point-wise comparisons among the SST datasets are small compared to the 61.08C accuracy of the NDBC SST sensors. Because skin-temperature variations from land to water so strongly affect the development and life cycle of the sea breeze, this phenomenon was chosen for demonstrating the use of the MODIS-based composite in an NWP model. A simulated sea breeze in the vicinity of New York City and Long Island shows a small, net, but far from universal improvement when MODIS-based composites are used in place of RTG analyses. The timing of the sea breeze s arrival is more accurate at some stations, and the near-surface temperature, wind, and humidity within the breeze are more realistic.

Global Changes In Relative Humidity: Moisture Recycling, Transport Processes And Implications For Drought Severity

NASA Astrophysics Data System (ADS)

Vicente-Serrano, S. M.; Gimeno, L.; Nieto, R. O.; Azorin-Molina, C.

2016-12-01

Climate models and observations suggest that atmospheric humidity is increasing as a consequence of warmer air temperatures according to the Classius-Clapeyron relationship. In addition, given unlimited water availability in oceans it is suggested that relative humidity (RH) would remain constant. Nevertheless, recent global and regional studies have pointed out that RH may be decreasing in large areas of the world, and there are different hypotheses that could explain the possible decrease in RH as related to changes in: (i) the atmospheric circulation and moisture transport processes; (ii) precipitation; (iii) air vapour saturation given different warming in lands and oceans; etc. These trends have strong implications for the atmospheric evaporative demand (AED) and drought severity. We analysed changes in RH observed at the global scale for 1979-2014. For this purpose we have used 3462 stations across the world from the HadISDH data set. RH data have been also calculated from daily records of specific humidity, air pressure and air temperature from the ERA-Interim Reanalysis data set. The comparison results between observations and ERA-Interim show a strong agreement in the spatio-temporal variability and magnitude of trends of RH. We have analysed the relationship between the variability and changes in RH, precipitation, air temperature and evaporation at the global scale, concluding that the observed spatial patterns of RH are not well explained by the observed changes in the variability of precipitation and temperature. To improve the knowledge of the possible drivers of the observed trends in RH, we have selected 15 representative areas that showed a different temporal behaviour and applied a Lagrangian model (Flexpart). This has served to identify the humidity sources corresponding to each region, and to know the behaviour showed by Sea Surface Temperature (SST) and the evolution of oceanic and continental evaporation processes on the RH variability and trends. The effect of observed RH trends on AED and drought severity has been evaluated by means of the Standardized Precipitation Evapotranspiration Index (SPEI).

Potential predictability of a Colombian river flow

NASA Astrophysics Data System (ADS)

Córdoba-Machado, Samir; Palomino-Lemus, Reiner; Quishpe-Vásquez, César; García-Valdecasas-Ojeda, Matilde; Raquel Gámiz-Fortis, Sonia; Castro-Díez, Yolanda; Jesús Esteban-Parra, María

2017-04-01

In this study the predictability of an important Colombian river (Cauca) has been analysed based on the use of climatic variables as potential predictors. Cauca River is considered one of the most important rivers of Colombia because its basin supports important productive activities related with the agriculture, such as the production of coffee or sugar. Potential relationships between the Cauca River seasonal streamflow anomalies and different climatic variables such as sea surface temperature (SST), precipitation (Pt), temperature over land (Tm) and soil water (Sw) have been analysed for the period 1949-2009. For this end, moving correlation analysis of 30 years have been carried out for lags from one to four seasons for the global SST, and from one to two seasons for South America Pt, Tm and Sw. Also, the stability of the significant correlations have been also studied, identifying the regions used as potential predictors of streamflow. Finally, in order to establish a prediction scheme based on the previous stable correlations, a Principal Component Analysis (PCA) applied on the potential predictor regions has been carried out in order to obtain a representative time series for each predictor field. Significant and stable correlations between the seasonal streamflow and the tropical Pacific SST (El Niño region) are found for lags from one to four (one-year) season. Additionally, some regions in the Indian and Atlantic Oceans also show significant and stable correlations at different lags, highlighting the importance that exerts the Atlantic SST on the hydrology of Colombia. Also significant and stable correlations are found with the Pt, Tm and Sw for some regions over South America, at lags of one and two seasons. The prediction of Cauca seasonal streamflow based on this scheme shows an acceptable skill and represents a relative improvement compared with the predictability obtained using the teleconnection indices associated with El Niño. Keywords: Streamflow, predictability, Cauca, Colombia. Acknowledgements: This work has been financed by the projects P11-RNM-7941 (Junta de Andalucía-Spain) and CGL2013-48539-R (MINECO-Spain, FEDER).

Cloning of TaSST genes associated with water soluble carbohydrate content in bread wheat stems and development of a functional marker.

PubMed

Dong, Yan; Zhang, Yan; Xiao, Yonggui; Yan, Jun; Liu, Jindong; Wen, Weie; Zhang, Yong; Jing, Ruilian; Xia, Xianchun; He, Zhonghu

2016-05-01

We cloned TaSST genes, developed a gene-specific marker for TaSST-D1, and identified three QTL in the Doumai/Shi 4185 RIL population. TaSST-D1 is within one of the three QTL. Sucrose:sucrose-1-fructosyltransferase (1-SST), a critical enzyme in the fructan biosynthetic pathway, is significantly and positively associated with water soluble carbohydrate (WSC) content in bread wheat stems. In the present study, wheat 1-SST genes (TaSST) were isolated and located on chromosomes 4A, 7A and 7D. Sequence analysis of TaSST-D1 revealed 15 single nucleotide polymorphisms (SNP) in the third exon between cultivars with higher and lower WSC content. A cleaved amplified polymorphism sequence (CAPS) marker, WSC7D, based on the polymorphism at position 1216 (C-G) was developed to discriminate the two alleles. WSC7D was located on chromosome 7DS using a recombinant inbred line (RIL) population from a Doumai/Shi 4185 cross, and a set of Chinese Spring nullisomic-tetrasomic lines. TaSST-D1 co-segregated with the CAPS marker WSC7D and was linked to SNP marker BS00108793_51 on chromosome 7DS at a genetic distance of 6.1 cM. It explained 8.8, 10.9, and 11.3% of the phenotypic variances in trials at Beijing and Shijiazhuang as well as the averaged data from those environments, respectively. Two additional QTL (QWSC.caas-4BS and QWSC.caas-7AS) besides TaSST-D1 were mapped in the RIL population. One hundred and forty-nine Chinese wheat cultivars and advanced lines tested in four environments were used to validate a highly significant (P < 0.01) association between WSC7D and WSC content in wheat stems. WSC7D can be used as a gene-specific marker for improvement of stem WSC content in wheat breeding programs.

Somatostatin protects photoreceptor cells against high glucose-induced apoptosis.

PubMed

Arroba, Ana I; Mazzeo, Aurora; Cazzoni, Daniele; Beltramo, Elena; Hernández, Cristina; Porta, Massimo; Simó, Rafael; Valverde, Ángela M

2016-01-01

Many cellular and molecular studies in experimental animals and early retinal function tests in patients with diabetic retinopathy (DR) have shown that retinal neurodegeneration is an early event in the pathogenesis of the disease. Somatostatin (SST) is one of the most important neuroprotective factors synthesized by the retina: SST levels are decreased in parallel to retinal neurodegeneration in early stages of DR. In this study, we characterized the induction of apoptosis (programmed cell death) in a 661W photoreceptor-like cell line cultured under high glucose (HG) conditions and the effect of SST. A 661W photoreceptor-like cell line and retinal explants from 10-week-old male C57BL/6 mice were cultured under HG conditions and treated with SST. Hyperglycemia significantly reduced the cellular viability by increasing the percentage of apoptotic cells, and this effect was ameliorated by SST (p˂0.05). Activation of caspase-8 by hyperglycemia was found in the 661W cells and retinal explants and decreased in the presence of SST (p˂0.05). Moreover, we detected activation of calpain-2 associated with hyperglycemia-induced cell death, as well as increased protein tyrosine phosphatase 1B (PTP1B) protein levels; both had a pattern of cleavage that was absent in the presence of SST (p˂0.05). Treatment of the 661W cells and retinal explants with SST for 24 h increased the phosphorylation of type 1 insulin-like growth factor receptor (IGF-IR; tyrosine 1165/1166) and protein kinase B (Akt; serine 473), suggesting this survival signaling is activated in the neuroretina by SST (p˂0.05). This study has provided new mechanistic insights first into the involvement of calpain-2 and PTP1B in the loss of cell survival and increased caspase-8-dependent apoptosis induced by hyperglycemia in photoreceptor cells and second, on the protective effect of SST against apoptosis by the enhancement of IGF-IR-mediated Akt phosphorylation.

Somatostatin protects photoreceptor cells against high glucose–induced apoptosis

PubMed Central

Mazzeo, Aurora; Cazzoni, Daniele; Beltramo, Elena; Hernández, Cristina; Porta, Massimo; Simó, Rafael; Valverde, Ángela M.

2016-01-01

Purpose Many cellular and molecular studies in experimental animals and early retinal function tests in patients with diabetic retinopathy (DR) have shown that retinal neurodegeneration is an early event in the pathogenesis of the disease. Somatostatin (SST) is one of the most important neuroprotective factors synthesized by the retina: SST levels are decreased in parallel to retinal neurodegeneration in early stages of DR. In this study, we characterized the induction of apoptosis (programmed cell death) in a 661W photoreceptor-like cell line cultured under high glucose (HG) conditions and the effect of SST. Methods A 661W photoreceptor-like cell line and retinal explants from 10-week-old male C57BL/6 mice were cultured under HG conditions and treated with SST. Results Hyperglycemia significantly reduced the cellular viability by increasing the percentage of apoptotic cells, and this effect was ameliorated by SST (p˂0.05). Activation of caspase-8 by hyperglycemia was found in the 661W cells and retinal explants and decreased in the presence of SST (p˂0.05). Moreover, we detected activation of calpain-2 associated with hyperglycemia-induced cell death, as well as increased protein tyrosine phosphatase 1B (PTP1B) protein levels; both had a pattern of cleavage that was absent in the presence of SST (p˂0.05). Treatment of the 661W cells and retinal explants with SST for 24 h increased the phosphorylation of type 1 insulin-like growth factor receptor (IGF-IR; tyrosine 1165/1166) and protein kinase B (Akt; serine 473), suggesting this survival signaling is activated in the neuroretina by SST (p˂0.05). Conclusions This study has provided new mechanistic insights first into the involvement of calpain-2 and PTP1B in the loss of cell survival and increased caspase-8-dependent apoptosis induced by hyperglycemia in photoreceptor cells and second, on the protective effect of SST against apoptosis by the enhancement of IGF-IR-mediated Akt phosphorylation. PMID:28050125

Interdecadal Change in SST Anomalies Associated with Winter Rainfall over South China

NASA Astrophysics Data System (ADS)

Liantong, Z.

2012-04-01

The present study investigates the interdecadal change in winter (January-February-March, or "JFM") rainfall over South China and in South China JFM rainfall-sea surface temperature (SST) relationship by using station observations for the period of 1958-2002, the Met Office Hadley Center's SST data for the period of 1900-2008, and the ERA-40 re-analysis for the period of 1958-2002. It is found that the relationship between South China JFM rainfall and SST experienced an obvious interdecadal change around the year 1978. The analyses show that the JFM rainfall anomalies during 1960-1977 and 1978-2002 were closely associated with the South China Sea (SCS) SST and El Niño-Southern Oscillation (ENSO), respectively. Moreover, southwesterly anomalies at 700 hPa dominate over the South China Sea for positive SCS SST anomaly years during 1960-1977, and for El Niño years during 1978-2002, respectively. These wind anomalies, which are associated with the enhancement of the western Pacific subtropical high, transport more moisture into South China, favoring increases in rainfall. KEY WORDS: ENSO; SCS SST; South China winter rainfall, western Pacific subtropical high.

Identifying and Investigating the Late-1960s Interhemispheric SST Shift

NASA Astrophysics Data System (ADS)

Friedman, A. R.; Lee, S. Y.; Liu, Y.; Chiang, J. C. H.

2014-12-01

The global north-south interhemispheric sea surface temperature (SST) difference experienced a pronounced and rapid decrease in the late 1960s, which has been linked to drying in the Sahel, South Asia, and East Asia. However, some basic questions about the interhemispheric SST shift remain unresolved, including its scale and whether the constituent changes in different basins were coordinated. In this study, we systematically investigate the spatial and temporal behavior of the late-1960s interhemispheric SST shift using ocean surface and subsurface observations. We also evaluate potential mechanisms using control and specific-forcing CMIP5 simulations. Using a regime shift detection technique, we identify the late-1960s shift as the most prominent in the historical observational SST record. We additionally examine the corresponding changes in upper-ocean heat content and salinity associated with the shift. We find that there were coordinated upper-ocean cooling and freshening in the subpolar North Atlantic, the region of the largest-magnitude SST decrease during the interhemispheric shift. These upper-ocean changes correspond to a weakened North Atlantic thermohaline circulation (THC). However, the THC decrease does not fully account for the rapid global interhemispheric SST shift, particularly the warming in the extratropical Southern Hemisphere.

A prospective cohort study of digital cushion and corium thickness. Part 1: Associations with body condition, lesion incidence, and proximity to calving.

PubMed

Newsome, R F; Green, M J; Bell, N J; Bollard, N J; Mason, C S; Whay, H R; Huxley, J N

2017-06-01

Claw horn disruption lesions (CHDL) are a major cause of lameness in dairy cattle and are likely a result of excessive forces being applied to the germinal epithelium that produces the claw horn. The digital cushion is a connective tissue structure, containing depots of adipose tissue, that sits beneath the distal phalanx and has been shown to be thicker in fatter cows. Body condition score (BCS) loss is a risk factor for CHDL, and one possible explanation is that fat is mobilized from the digital cushion during negative energy balance, causing the digital cushion to thin and lose force-dissipating capacity, leading to disruption of claw horn growth. This prospective cohort study investigated the association between measures of body fat and sole soft tissue (SST) thickness (a combined measure of the corium and digital cushion beneath the distal phalanx) in a longitudinal manner. The SST of 179 cows in 2 high-yielding dairy herds were measured at 5 assessment points between 8 wk before and 35 wk postcalving. The BCS, back fat thickness (BFT), and lesion incidence were recorded. Data were analyzed in a 4-level mixed effects regression model, with the outcome being SST thickness beneath the flexor tuberosity of the distal phalanx. Data from 827 assessment points were available for analysis. The overall mean of SST was 4.99 mm (standard deviation: 0.95). The SST was thickest 8 wk before calving (5.22 mm, standard deviation: 0.91) and thinnest 1 wk postcalving (4.68 mm, standard deviation: 0.87), suggesting an effect of calving on SST. The BFT was positively correlated with SST in the model with a small effect size (a 10 mm decrease in BFT corresponded with a 0.13 mm decrease in SST), yet the nadir of BFT was 11.0 mm at 9 to 17 wk postcalving (when SST was ∼4.95 mm), rather than occurring with the nadir of SST immediately after calving. The SST also varied with other variables [e.g., cows that developed a sole ulcer or severe sole hemorrhage during the study had thinner SST (-0.24 mm)], except when a sole ulcer was present, when it was thicker (+0.53 mm). Cows that developed lesions had a thinner digital cushion before the lesion occurrence, which became thickened with sole ulcer presence, perhaps representing inflammation. Furthermore, although BFT was correlated with SST over time, SST may also have been influenced by other factors such as integrity of the suspensory apparatus, which could have a major effect on CHDL. Measures of body fat likely contributed to having thin SST, but other factors including calving, herd, and lesion presence also had an effect. The Authors. Published by the Federation of Animal Science Societies and Elsevier Inc. on behalf of the American Dairy Science Association®. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

Research on MMC-SST Oriented AC/DC Distribution System

NASA Astrophysics Data System (ADS)

Xie, Xifeng; Shi, Hua; Zuo, Jianglin; Zhang, Zhigang

2018-01-01

A modular multilevel converter-solid state transformer (MMC-SST) oriented AC/DC Distribution System is designed. Firstly, the topology structure is introduced, MMC is adopted in the input stage, multiple DC-DC converters are adopted in the isolation stage, and a Three-Phase Four-Leg inverter is adopted in the output stage. Then, the control strategy is analysed. Finally, simulation model and an experimental prototype of MMC-SST are built, simulation and experimental results show that topology and control strategy of MMC-SST are feasible.

A pilot of a video game (DDR) to promote physical activity and decrease sedentary screen time.

PubMed

Maloney, Ann E; Bethea, T Carter; Kelsey, Kristine S; Marks, Julie T; Paez, Sadye; Rosenberg, Angela M; Catellier, Diane J; Hamer, Robert M; Sikich, Linmarie

2008-09-01

We examined the feasibility of Dance Dance Revolution (DDR), a dance video game, in participants' homes, to increase physical activity (PA) and to decrease sedentary screen time (SST). Sixty children (7.5 +/- 0.5 years) were randomized in a 2:1 ratio to DDR or to wait-list control (10-week delay). DDR use was logged, PA was measured objectively by accelerometry. SST was self-reported at weeks 0 and 10. At week 28, after both groups had access to DDR, accelerometry and SST were repeated. Mean use of DDR was 89 +/- 82 (range 0-660 min) min per week (mpw). The DDR group showed increased vigorous PA and a reduction in light PA; the control group showed no increase in moderate and/or vigorous PA (MVPA) although they also had a reduction in light PA. Differences between the groups were not observed. The DDR group also reported a decrease in SST of -1.2 +/- 3.7 h per week (hpw) (P < 0.05), whereas the controls reported an increase of +3.0 +/- 7.7 hpw (nonsignificant). The difference in SST between the groups was significant, with less SST in the DDR group. Between weeks 10 and 28, numeric reductions in SST were reported in both groups. In the DDR group, SST at week 28 (8.8 +/- 6.0 hpw) was lower than baseline (10.5 +/- 5.5 hpw; P < 0.03). This pilot study suggests that DDR reduces SST and may facilitate slight increases in vigorous PA. Further study is needed to better characterize children and contexts in which DDR may promote a healthy lifestyle.

Shaping climate change in the North Atlantic sector: The role of the atmospheric response to local SST changes vs. large-scale changes

NASA Astrophysics Data System (ADS)

Hand, Ralf; Keenlyside, Noel; Omrani, Nour-Eddine; Greatbatch, Richard; Bader, Jürgen

2017-04-01

Climate change simulations robustly show a warming hole in the sub-polar North Atlantic that results from slowing of the AMOC countering the global warming signal. Here we investigate how the distinct SST spatial structures, which include a sharpening of the Gulf Stream SST gradients, influence climate change in the NA sector in winter. For this we analyse the RCP8.5 scenario simulation of the MPI Earth System Model. Additional sensitivity experiments with the atmospheric model component, ECHAM5, are performed to deconstruct the effect of the local spatial structure of the SST change from those arising from large-scale warming of the ocean, remote SST pattern changes and changed radiative forcings. The MPI model simulation shows a signifcant decrease in precipitation to the south of the GS extension region in the future, despite a strong increase in underlying SST. While directly to the north there is a significant increase in precipitation. These distinct features in the precipitation response over the North Atlantic result from the local SST. Over the Gulf Stream, the differential structure of the precipitation changes reflects the changes of the local SST gradients there. Over the subpolar gyre the increase in precipitation is partly suppressed. In this region the Subpolar Gyre the weakened AMOC causes a SST warming, that is much weaker than the warming other regions of the ocean show at the same latitude. The large-scale response, which includes the overall increase in precipitation over the NA is due to the overall warming, remote SSTs and/or directly connected to the radiative forcing.

El Niño–Southern Oscillation diversity and Southern Africa teleconnections during Austral Summer

USGS Publications Warehouse

Hoell, Andrew; Funk, Christopher C.; Magadzire, Tamuka; Zinke, Jens; Husak, Gregory J.

2014-01-01

A wide range of sea surface temperature (SST) expressions have been observed during the El Niño–Southern Oscillation events of 1950–2010, which have occurred simultaneously with different global atmospheric circulations. This study examines the atmospheric circulation and precipitation during December–March 1950–2010 over the African Continent south of 15∘S, a region hereafter known as Southern Africa, associated with eight tropical Pacific SST expressions characteristic of El Niño and La Niña events. The self-organizing map method along with a statistical distinguishability test was used to isolate the SST expressions of El Niño and La Niña. The seasonal precipitation forcing over Southern Africa associated with the eight SST expressions was investigated in terms of the horizontal winds, moisture budget and vertical motion. El Niño events, with warm SST across the east and central Pacific Ocean and warmer than average SST over the Indian Ocean, are associated with precipitation reductions over Southern Africa. The regional precipitation reductions are forced primarily by large-scale mid-tropospheric subsidence associated with anticyclonic circulation in the upper troposphere. El Niño events with cooler than average SST over the Indian Ocean are associated with precipitation increases over Southern Africa associated with lower tropospheric cyclonic circulation and mid-tropospheric ascent. La Niña events, with cool SST anomalies over the central Pacific and warm SST over the west Pacific and Indian Ocean, are associated with precipitation increases over Southern Africa. The regional precipitation increases are forced primarily by lower tropospheric cyclonic circulation, resulting in mid-tropospheric ascent and an increased flux of moisture into the region.

Assessing the Utility of Seasonal SST Forecasts to the Fisheries Management Process: a Pacific Sardine Case Study

NASA Astrophysics Data System (ADS)

Tommasi, D.; Stock, C. A.

2016-02-01

It is well established that environmental fluctuations affect the productivity of numerous fish stocks. Recent advances in prediction capability of dynamical global forecast systems, such as the state of the art NOAA Geophysical Fluid dynamics Laboratory (GFDL) 2.5-FLOR model, allow for climate predictions of fisheries-relevant variables at temporal scales relevant to the fishery management decision making process. We demonstrate that the GFDL FLOR model produces skillful seasonal SST anomaly predictions over the continental shelf , where most of the global fish yield is generated. The availability of skillful SST projections at this "fishery relevant" scale raises the potential for better constrained estimates of future fish biomass and improved harvest decisions. We assessed the utility of seasonal SST coastal shelf predictions for fisheries management using the case study of Pacific sardine. This fishery was selected because it is one of the few to already incorporate SST into its harvest guideline, and show a robust recruitment-SST relationship. We quantified the effectiveness of management under the status quo harvest guideline (HG) and under alternative HGs including future information at different levels of uncertainty. Usefulness of forecast SST to management was dependent on forecast uncertainty. If the standard deviation of the SST anomaly forecast residuals was less than 0.65, the alternative HG produced higher long-term yield and stock biomass, and reduced the probability of either catch or stock biomass falling below management-set threshold values as compared to the status quo. By contrast, probability of biomass falling to extremely low values increased as compared to the status quo for all alternative HGs except for a perfectly known future SST case. To safeguard against occurrence of such low probability but costly events, a harvest cutoff biomass also has to be implemented into the HG.

Effect of extreme sea surface temperature events on the demography of an age-structured albatross population.

PubMed

Pardo, Deborah; Jenouvrier, Stéphanie; Weimerskirch, Henri; Barbraud, Christophe

2017-06-19

Climate changes include concurrent changes in environmental mean, variance and extremes, and it is challenging to understand their respective impact on wild populations, especially when contrasted age-dependent responses to climate occur. We assessed how changes in mean and standard deviation of sea surface temperature (SST), frequency and magnitude of warm SST extreme climatic events (ECE) influenced the stochastic population growth rate log( λ s ) and age structure of a black-browed albatross population. For changes in SST around historical levels observed since 1982, changes in standard deviation had a larger (threefold) and negative impact on log( λ s ) compared to changes in mean. By contrast, the mean had a positive impact on log( λ s ). The historical SST mean was lower than the optimal SST value for which log( λ s ) was maximized. Thus, a larger environmental mean increased the occurrence of SST close to this optimum that buffered the negative effect of ECE. This 'climate safety margin' (i.e. difference between optimal and historical climatic conditions) and the specific shape of the population growth rate response to climate for a species determine how ECE affect the population. For a wider range in SST, both the mean and standard deviation had negative impact on log( λ s ), with changes in the mean having a greater effect than the standard deviation. Furthermore, around SST historical levels increases in either mean or standard deviation of the SST distribution led to a younger population, with potentially important conservation implications for black-browed albatrosses.This article is part of the themed issue 'Behavioural, ecological and evolutionary responses to extreme climatic events'. © 2017 The Author(s).

Interdecadal variability in pan-Pacific and global SST, revisited

NASA Astrophysics Data System (ADS)

Tung, Ka-Kit; Chen, Xianyao; Zhou, Jiansong; Li, King-Fai

2018-05-01

Interest in the "Interdecadal Pacific Oscillation (IPO)" in the global SST has surged recently on suggestions that the Pacific may be the source of prominent interdecadal variations observed in the global-mean surface temperature possibly through the mechanism of low-frequency modulation of the interannual El Nino-Southern Oscillation (ENSO) phenomenon. IPO was defined by performing empirical orthogonal function (EOF) analysis of low-pass filtered SST. The low-pass filtering creates its unique set of mathematical problems—in particular, mode mixing—and has led to some questions, many unanswered. To understand what these EOFs are, we express them first in terms of the recently developed pairwise rotated EOFs of the unfiltered SST, which can largely separate the high and low frequency bands without resorting to filtering. As reported elsewhere, the leading rotated dynamical modes (after the global warming trend) of the unfiltered global SST are: ENSO, Pacific Decadal Oscillation (PDO), and Atlantic Multidecadal Oscillation (AMO). IPO is not among them. The leading principal component (PC) of the low-pass filtered global SST is usually defined as IPO and it is seen to comprise of ENSO, PDO and AMO in various proportions depending on the filter threshold. With decadal filtering, the contribution of the interannual ENSO is understandably negligible. The leading dynamical mode of the filtered global SST is mostly AMO, and therefore should not have been called the Interdecadal "Pacific" Oscillation. The leading dynamical mode of the filtered pan-Pacific SST is mostly PDO. This and other low-frequency variability that have the action center in the Pacific, from either the pan-Pacific or global SST, have near zero global mean.

Comparison of intracorporeal single-stapled and double-stapled anastomosis in laparoscopic low anterior resection for rectal cancer: a case-control study.

PubMed

Kim, Hye Jin; Choi, Gyu-Seog; Park, Jun Seok; Park, Soo Yeun

2013-01-01

Recently, a single-stapled technique (SST) was performed instead of the conventional double-stapled technique (DST) in laparoscopic low anterior resection for anastomosis, by placement of intracorporeal purse-string sutures on the distal rectum with transanal specimen extraction. This study aimed to compare the short-term outcomes between the two anastomotic techniques. Between July 2007 and April 2010, 60 patients underwent SST by laparoscopic or robotic procedure. These patients were matched 1:2 by age, gender, date of surgery, and tumor stage with 120 patients who underwent conventional DST in laparoscopic low anterior resection. The robotic-assisted operative approach was used more frequently in the SST group than in the DST group (61.7 % vs. 3.3 %, p < 0.001). The mean operative time was 203.9 (range, 120-400) min for the SST group and 167.6 (range, 90-300) min for the DST group (p < 0.001). For specimen removal, the transanal approach was used in the SST group, while the transabdominal approach was used for the DST group. The pain score (visual analogue scale) of the SST group was lower (4.5 vs. 5.6, p < 0.001), although postoperative recovery was similar. Pathological examination revealed that the distal resection margin was significantly longer in the SST group (3.1 vs. 2.5 cm, p = 0.018). Postoperative morbidity including anastomotic leakage was similar in both groups. SST yielded equivalent short-term outcomes when compared to conventional DST and provided the advantages of minimal access and a longer distal resection margin. Therefore, SST in lower anterior resection may be a useful alternative to conventional DST.

Sr/Ca proxy sea-surface temperature reconstructions from modern and holocene Montastraea faveolata specimens from the Dry Tortugas National Park

USGS Publications Warehouse

Flannery, Jennifer A.; Poore, Richard Z.

2013-01-01

Sr/Ca ratios from skeletal samples from two Montastraea faveolata corals (one modern, one Holocene, ~6 Ka) from the Dry Tortugas National Park were measured as a proxy for sea-surface temperature (SST). We sampled coral specimens with a computer-driven triaxial micromilling machine, which yielded an average of 15 homogenous samples per annual growth increment. We regressed Sr/Ca values from resulting powdered samples against a local SST record to obtain a calibration equation of Sr/Ca = -0.0392 SST + 10.205, R = -0.97. The resulting calibration was used to generate a 47-year modern (1961-2008) and a 7-year Holocene (~6 Ka) Sr/Ca subannually resolved proxy record of SST. The modern M. faveolata yields well-defined annual Sr/Ca cycles ranging in amplitude from ~0.3 and 0.5 mmol/mol. The amplitude of ~0.3 to 0.5 mmol/mol equates to a 10-15°C seasonal SST amplitude, which is consistent with available local instrumental records. Summer maxima proxy SSTs calculated from the modern coral Sr/ Ca tend to be fairly stable: most SST maxima from 1961–2008 are 29°C ± 1°C. In contrast, winter minimum SST calculated in the 47-year modern time-series are highly variable, with a cool interval in the early to mid-1970s. The Holocene (~6 Ka) Montastraea faveolata coral also yields distinct annual Sr/Ca cycles with amplitudes ranging from ~0.3 to 0.6 mmol/mol. Absolute Sr/Ca values and thus resulting SST estimates over the ~7-year long record are similar to those from the modern coral. We conclude that Sr/Ca from Montastraea faveolata has high potential for developing subannually resolved Holocene SST records.

Octreotide promotes apoptosis in human somatotroph tumor cells by activating somatostatin receptor type 2.

PubMed

Ferrante, E; Pellegrini, C; Bondioni, S; Peverelli, E; Locatelli, M; Gelmini, P; Luciani, P; Peri, A; Mantovani, G; Bosari, S; Beck-Peccoz, P; Spada, A; Lania, A

2006-09-01

Somatostatin analogs currently used in the treatment of acromegaly and other neuroendocrine tumors inhibit hormone secretion and cell proliferation by binding to somatostatin receptor type (SST) 2 and 5. The antiproliferative pathways coupled to these receptors have been only partially characterized. The aim of this study was to evaluate the effect of octreotide and super selective SST2 (BIM23120) and SST5 (BIM23206) analogs on apoptotic activity and apoptotic gene expression in human somatotroph tumor cells. Eight somatotroph tumors expressing similar levels of SST2 and SST5 evaluated by real-time PCR and western blot analyses were included in the study. In cultured cells obtained from these tumors, octreotide induced a dose-dependent increase of caspase-3 activity (160+/-20% vs basal at 10 nM) and cleaved cytokeratin 18 levels (172+/-25% vs basal) at concentrations higher than 0.1 nM. This effect was due to SST2 activation since BIM23120 elicited comparable responses, while BIM23206 was ineffective. BIM23120-stimulated apoptosis was dependent on phosphatases, since it was abrogated by the inhibitor orthovanadate, and independent from the induction of apoptosis-related genes, such as p53, p63, p73, Bcl-2, Bax, BID, BIK, TNFSF8, and FADD. In somatotroph tumors, both BIM23120 and BIM2306 caused growth arrest as indicated by the increase in p27 and decrease in cyclin D1 expression. In conclusion, the present study showed that octreotide-induced apoptosis in human somatotroph tumor cells by activating SST2. This effect, together with the cytostatic action exerted by both SST2 and SST5 analogs, might account for the tumor shrinkage observed in acromegalic patients treated with long-acting somatostatin analogs.

Enhanced influence of early-spring tropical Indian Ocean SST on the following early-summer precipitation over Northeast China

NASA Astrophysics Data System (ADS)

Han, Tingting; He, Shengping; Wang, Huijun; Hao, Xin

2017-04-01

The relationship between the tropical Indian Ocean (TIO) and East Asian summer monsoon/precipitation has been documented in many studies. However, the precursor signals of summer precipitation in the TIO sea surface temperature (SST), which is important for climate prediction, have drawn little attention. This study identified a strong relationship between early-spring TIO SST and subsequent early-summer precipitation in Northeast China (NEC) since the late 1980s. For 1961-1986, the correlations between early-spring TIO SST and early-summer NEC precipitation were statistically insignificant; for 1989-2014, they were positively significant. Since the late 1980s, the early-spring positive TIO SST anomaly was generally followed by a significant anomalous anticyclone over Japan; that facilitated anomalous southerly winds over NEC, conveying more moisture from the North Pacific. Further analysis indicated that an early TIO SST anomaly showed robust persistence into early summer. However, the early-summer TIO SST anomaly displayed a more significant influence on simultaneous atmospheric circulation and further affected NEC precipitation since the late 1980s. In 1989-2014, the early-summer Hadley and Ferrell cell anomalies associated with simultaneous TIO SST anomaly were much more significant and extended further north to mid-latitudes, which provided a dynamic foundation for the TIO-mid-latitude connection. Correspondingly, the TIO SST anomaly could lead to significant divergence anomalies over the Mediterranean. The advections of vorticity by the divergent component of the flow effectively acted as a Rossby wave source. Thus, an apparent Rossby wave originated from the Mediterranean and propagated east to East Asia; that further influenced the NEC precipitation through modulation to the atmospheric circulation (e.g., surface wind, moisture, vertical motion).

SST cooling along coastal Java and Sumatra during positive Indian Ocean Dipole events

NASA Astrophysics Data System (ADS)

Delman, A. S.; McClean, J.; Sprintall, J.; Talley, L. D.; Bryan, F.; Johnson, B. K.; Carton, J.

2016-02-01

The evolution of positive Indian Ocean Dipole (pIOD) events is driven in part by anomalous SST cooling near the coasts of Java and Sumatra. However, the mechanisms and timeline of surface temperature changes near these two islands are distinct. Satellite data and mixed layer budgets in a forced ocean model simulation with 0.1° spatial resolution were used to characterize the dominant influences on SST in each region during pIOD events. Along the south coast of Java, where upwelling from southeasterly trade winds happens seasonally in June-September, strengthening/weakening of the trade winds has little effect on the interannual variability of SST. Instead, remotely-forced upwelling Kelvin waves are the primary mechanism for producing anomalous Java SST cooling in the early stages of a pIOD event. Other mechanisms that affect Java SST anomalies include inflows from the interior Indonesian Seas, mesoscale eddies, and air-sea heat fluxes; these influences can hasten the decay of cool Java SST anomalies and therefore may impact the strength and duration of pIOD events. Along the west coast of Sumatra, surface cooling is initially delayed by a deeper thermocline and a salinity-stratified barrier layer. Hence upwelling Kelvin waves do not substantially affect SST near Sumatra during the first 2-3 months of Java SST cooling; however, they do help drive surface cooling near Sumatra once the barrier layer has been sufficiently eroded by waters of decreasing temperature and increasing salinity. Upwelling Kelvin wave activity in the equatorial Indian Ocean starting in April is also shown to be a robust predictor of pIOD events later in the calendar year.

Preparation and biological evaluation of 64Cu-CB-TE2A-sst2-ANT, a somatostatin antagonist for PET imaging of somatostatin receptor-positive tumors.

PubMed

Wadas, Thaddeus J; Eiblmaier, Martin; Zheleznyak, Alexander; Sherman, Christopher D; Ferdani, Riccardo; Liang, Kexian; Achilefu, Samuel; Anderson, Carolyn J

2008-11-01

Recently, the somatostatin receptor subtype 2 (SSTR2) selective antagonist sst2-ANT was determined to have a high affinity for SSTR2. Additionally, 111In-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-sst2-ANT showed high uptake in an SSTR2-transfected, tumor-bearing mouse model and suggested that radiolabeled SSTR2 antagonists may be superior to agonists for imaging SSTR2-positive tumors. This report describes the synthesis and evaluation of 64Cu-CB-4,11-bis(carboxymethyl)-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane-sst2-ANT (64Cu-CB-TE2A-sst2-ANT) as a PET radiopharmaceutical for the in vivo imaging of SSTR2-positive tumors. Receptor-binding studies were performed to determine the dissociation constant of the radiopharmaceutical 64Cu-CB-TE2A-sst2-ANT using AR42J rat pancreatic tumor cell membranes. The internalization of 64Cu-CB-TE2A-sst2-ANT was compared with that of the 64Cu-labeled agonist 64Cu-CB-TE2A-tyrosine3-octreotate (64Cu-CB-TE2A-Y3-TATE) in AR42J cells. Both radiopharmaceuticals were also compared in vivo through biodistribution studies using healthy rats bearing AR42J tumors, and small-animal PET/CT of 64Cu-CB-TE2A-sst2-ANT was performed. The dissociation constant value for the radiopharmaceutical was determined to be 26 +/- 2.4 nM, and the maximum number of binding sites was 23,000 fmol/mg. 64Cu-CB-TE2A-sst2-ANT showed significantly less internalization than did 64Cu-CB-TE2A-Y3-TATE at time points from 15 min to 4 h. Biodistribution studies revealed that the clearance of 64Cu-CB-TE2A-sst2-ANT from the blood was rapid, whereas the clearance of 64Cu-CB-TE2A-sst2-ANT from the liver and kidneys was more modest at all time points. Tumor-to-blood and tumor-to-muscle ratios were determined to be better for 64Cu-CB-TE2A-sst2-ANT than those for 64Cu-CB-TE2A-Y3-TATE at the later time points, although liver and kidney uptake was significantly higher. Small-animal imaging using 64Cu-CB-TE2A-sst2-ANT revealed excellent tumor-to-background contrast at 4 h after injection, and standardized uptake values remained high even after 24 h. The PET radiopharmaceutical 64Cu-CB-TE2A-sst2-ANT is an attractive agent, worthy of future study as a PET radiopharmaceutical for the imaging of somatostatin receptor-positive tumors.

The Mg - SST relationship in mollusc shells: is there a rule? Examples from three tropical species

NASA Astrophysics Data System (ADS)

Lazareth, C. E.; Guzmán, N.; Lecornec, F.; Cabioch, G.; Ortlieb, L.

2009-04-01

The geochemistry of mollusc shells is currently viewed as a powerful tool for paleoenvironmental reconstructions. Indeed, molluscs are ubiquitous animals, with a worldly geographical and environmental distribution, providing various environmental records. Moreover, mollusc shells are abundantly found in fossil and archaeological settings. In the paleoclimatic reconstructions, the sea-surface temperatures (SST) are a key parameter. If shell stable oxygen isotope signatures can provide accurate SST records, this proxy is also influenced by the water isotopic composition. To find another tracer which would depend on the SST solely, the relationship between Mg content changes in mollusc shell and SST has been investigated for a few years. Nevertheless, if the reliability of shell Mg as SST tracer has been proven in some species, this is clearly not a "universal" and definitive rule. To reconstruct the past tropical SSTs, Mg calibration studies were undertaken on Concholepas concholepas (gastropod, South America), Protothaca thaca (bivalve, South America) and Tridacna squamosa (bivalve, New Caledonia). The very high-resolution (infra-daily) analyses of the C. concholepas gastropod revealed a significant metabolism control, at the nyctemeral scale, on the Mg incorporation into the calcite shell layer. Over a two months period, the Mg fluctuations in C. concholepas shell do not match with the SST instrumental measurements. Mg content changes along the aragonitic shell growth axis of several living P. thaca from a same Peruvian site are significantly different indicating no relationship between Mg and SST. The Mg variations measured in a Chilean P. thaca shell are, surprisingly, similar to variations of the instrumental SST. Unless this quite reliable relationship between P. thaca shell and SST is confirmed, and that the inter-site difference in Mg response to environmental forcing is understood, P. thaca shell Mg cannot be used as SST proxy. Lastly, a preliminary work carried out on the external aragonitic shell layer of T. squamosa showed that, over 14 months of growth, Mg and SST are well conversely correlated but the seasonal cycle is interrupted by a Mg peak that corresponds to a shell growth anomaly. Additional studies, especially dedicated on anomalies-related Mg increases, must be performed to validate the T. squamosa shell as a reliable SST proxy. Considering previous works and the results presented here, one can definitively conclude that, at least, calibration procedures are indispensable before using Mg as a SST proxy in mollusc shells. In addition, further work specifically directed towards the role of the metabolism on the incorporation of Mg in mollusc shells could be the key to understand, and thus to use, this proxy for which, at the present time, no single rule is applicable to molluscs. Contribution of the CONCHAS (PNEDC), CENSOR (6th PCRD) and BioCalc (ESF) projects. "This study was financed and conducted in the frame of the EU-project CENSOR (Climate variability and El Nino Southern Oscillation: Impacts for natural resources and management, contract 511071) and is CENSOR publication 0375".

ENSO modulation of tropical Indian Ocean subseasonal variability

NASA Astrophysics Data System (ADS)

Jung, Eunsil; Kirtman, Ben P.

2016-12-01

In this study, we use 30 years of retrospective climate model forecasts and observational estimates to show that El Niño/Southern Oscillation (ENSO) affects the amplitude of subseasonal variability of sea surface temperature (SST) in the southwest Indian Ocean, an important Tropical Intraseasonal Oscillation (TISO) onset region. The analysis shows that deeper background mixed-layer depths and warmer upper ocean conditions during El Niño reduce the amplitude of the subseasonal SST variability over Seychelles-Chagos Thermocline Ridge (SCTR), which may reduce SST-wind coupling and the amplitude of TISO variability. The opposite holds for La Niña where the shallower mixed-layer depth enhances SST variability over SCTR, which may increase SST-wind coupling and the amplitude of TISO variability.

Reevaluation of mid-Pliocene North Atlantic sea surface temperatures

USGS Publications Warehouse

Robinson, Marci M.; Dowsett, Harry J.; Dwyer, Gary S.; Lawrence, Kira T.

2008-01-01

Multiproxy temperature estimation requires careful attention to biological, chemical, physical, temporal, and calibration differences of each proxy and paleothermometry method. We evaluated mid-Pliocene sea surface temperature (SST) estimates from multiple proxies at Deep Sea Drilling Project Holes 552A, 609B, 607, and 606, transecting the North Atlantic Drift. SST estimates derived from faunal assemblages, foraminifer Mg/Ca, and alkenone unsaturation indices showed strong agreement at Holes 552A, 607, and 606 once differences in calibration, depth, and seasonality were addressed. Abundant extinct species and/or an unrecognized productivity signal in the faunal assemblage at Hole 609B resulted in exaggerated faunal-based SST estimates but did not affect alkenone-derived or Mg/Ca–derived estimates. Multiproxy mid-Pliocene North Atlantic SST estimates corroborate previous studies documenting high-latitude mid-Pliocene warmth and refine previous faunal-based estimates affected by environmental factors other than temperature. Multiproxy investigations will aid SST estimation in high-latitude areas sensitive to climate change and currently underrepresented in SST reconstructions.

Western tropical Pacific multidecadal variability forced by the Atlantic multidecadal oscillation

PubMed Central

Sun, Cheng; Kucharski, Fred; Li, Jianping; Jin, Fei-Fei; Kang, In-Sik; Ding, Ruiqiang

2017-01-01

Observational analysis suggests that the western tropical Pacific (WTP) sea surface temperature (SST) shows predominant variability over multidecadal time scales, which is unlikely to be explained by the Interdecadal Pacific Oscillation. Here we show that this variability is largely explained by the remote Atlantic multidecadal oscillation (AMO). A suite of Atlantic Pacemaker experiments successfully reproduces the WTP multidecadal variability and the AMO–WTP SST connection. The AMO warm SST anomaly generates an atmospheric teleconnection to the North Pacific, which weakens the Aleutian low and subtropical North Pacific westerlies. The wind changes induce a subtropical North Pacific SST warming through wind–evaporation–SST effect, and in response to this warming, the surface winds converge towards the subtropical North Pacific from the tropics, leading to anomalous cyclonic circulation and low pressure over the WTP region. The warm SST anomaly further develops due to the SST–sea level pressure–cloud–longwave radiation positive feedback. Our findings suggest that the Atlantic Ocean acts as a key pacemaker for the western Pacific decadal climate variability. PMID:28685765

Decadal changes in South Pacific sea surface temperatures and the relationship to the Pacific decadal oscillation and upper ocean heat content

NASA Astrophysics Data System (ADS)

Linsley, Braddock K.; Wu, Henry C.; Dassié, Emilie P.; Schrag, Daniel P.

2015-04-01

Decadal changes in Pacific sea surface temperatures (SSTs) and upper ocean heat content (OHC) remain poorly understood. We present an annual average composite coral Sr/Ca-derived SST time series extending back to 1791 from Fiji, Tonga, and Rarotonga (FTR) in the Pacific Decadal Oscillation (PDO) sensitive region of the southwest Pacific. Decadal SST maxima between 1805 and 1830 Common Era (C.E.) indicate unexplained elevated SSTs near the end of the Little Ice Age. The mean period of decadal SST variability in this region has a period near 25 years. Decades of warmer (cooler) FTR SST co-occur with PDO negative (positive) phases since at least ~1930 C.E. and positively correlate with South Pacific OHC (0-700 m). FTR SST is also inversely correlated with decadal changes in equatorial Pacific SST as measured by coral Sr/Ca. Collectively, these results support the fluctuating trade wind-shallow meridional overturning cell mechanism for decadal modulation of Pacific SSTs and OHC.

Relationships of Upper Tropospheric Water Vapor, Clouds and SST: MLS Observations, ECMWF Analyses and GCM Simulations

NASA Technical Reports Server (NTRS)

Su, Hui; Waliser, Duane E.; Jiang, Jonathan H.; Li, Jui-lin; Read, William G.; Waters, Joe W.; Tompkins, Adrian M.

2006-01-01

The relationships of upper tropospheric water vapor (UTWV), cloud ice and sea surface temperature (SST) are examined in the annual cycles of ECMWF analyses and simulations from 15 atmosphere-ocean coupled models which were contributed to the IPCC AR4. The results are compared with the observed relationships based on UTWV and cloud ice measurements from MLS on Aura. It is shown that the ECMWF analyses produce positive correlations between UTWV, cloud ice and SST, similar to the MLS data. The rate of the increase of cloud ice and UTWV with SST is about 30% larger than that for MLS. For the IPCC simulations, the relationships between UTWV, cloud ice and SST are qualitatively captured. However, the magnitudes of the simulated cloud ice show a considerable disagreement between models, by nearly a factor of 10. The amplitudes of the approximate linear relations between UTWV, cloud ice and SST vary by a factor up to 4.

Sea Surface Temperature Products and Research Associated with GHRSST

NASA Astrophysics Data System (ADS)

Kaiser-Weiss, Andrea K.; Minnett, Peter J.; Kaplan, Alexey; Wick, Gary A.; Castro, Sandra; Llewellyn-Jones, David; Merchant, Chris; LeBorgne, Pierre; Beggs, Helen; Donlon, Craig J.

2012-03-01

GHRSST serves its user community through the specification of operational Sea Surface Temperature (SST) products (Level 2, Level 3 and Level 4) based on international consensus. Providers of SST data from individual satellites create and deliver GHRSST-compliant near-real time products to a global GHRSST data assembly centre and a long-term stewardship facility. The GHRSST-compliant data include error estimates and supporting data for interpretation. Groups organised within GHRSST perform research on issues relevant to applying SST for air-sea exchange, for instance the Diurnal Variability Working Group (DVWG) analyses the evolution of the skin temperature. Other GHRSST groups concentrate on improving the SST estimate (Estimation and Retrievals Working Group EARWiG) and on improving the error characterization, (Satellite SST Validation Group, ST-VAL) and on improving the methods for SST analysis (Inter-Comparison Technical Advisory Group, IC-TAG). In this presentation we cover the data products and the scientific activities associated with GHRSST which might be relevant for investigating ocean-atmosphere interactions.

Combined effects of recent Pacific cooling and Indian Ocean warming on the Asian monsoon.

PubMed

Ueda, Hiroaki; Kamae, Youichi; Hayasaki, Masamitsu; Kitoh, Akio; Watanabe, Shigeru; Miki, Yurisa; Kumai, Atsuki

2015-11-13

Recent research indicates that the cooling trend in the tropical Pacific Ocean over the past 15 years underlies the contemporaneous hiatus in global mean temperature increase. During the hiatus, the tropical Pacific Ocean displays a La Niña-like cooling pattern while sea surface temperature (SST) in the Indian Ocean has continued to increase. This SST pattern differs from the well-known La Niña-induced basin-wide cooling across the Indian Ocean on the interannual timescale. Here, based on model experiments, we show that the SST pattern during the hiatus explains pronounced regional anomalies of rainfall in the Asian monsoon region and thermodynamic effects due to specific humidity change are secondary. Specifically, Indo-Pacific SST anomalies cause convection to intensify over the tropical western Pacific, which in turn suppresses rainfall in mid-latitude East Asia through atmospheric teleconnection. Overall, the tropical Pacific SST effect opposes and is greater than the Indian Ocean SST effect.

Midlatitude atmosphere-ocean interaction during El Nino. Part I. The north Pacific ocean

DOE Office of Scientific and Technical Information (OSTI.GOV)

Alexander, M.A.

Atmosphere-ocean modeling experiments are used to investigate the formation of sea surface temperature (SST) anomalies in the North Pacific Ocean during fall and winter of the El Nino year. Experiments in which the NCAR Community Climate Model (CCM) surface fields are used to force a mixed-layer ocean model in the North Pacific (no air-sea feedback) are compared to simulations in which the CCM and North Pacific Ocean model are coupled. Anomalies in the atmosphere and the North Pacific Ocean during El Nino are obtained from the difference between simulations with and without prescribed warm SST anomalies in the tropical Pacific.more » In both the forced and coupled experiments, the anomaly pattern resembles a composite of the actual SST anomaly field during El Nino: warm SSTs develop along the coast of North America and cold SSTs form in the central Pacific. In the coupled simulations, air-sea interaction results in a 25% to 50% reduction in the magnitude of the SST and mixed-layer depth anomalies, resulting in more realistic SST fields. Coupling also decreases the SST anomaly variance; as a result, the anomaly centers remain statistically significant even though the magnitude of the anomalies is reduced. Three additional sensitivity studies indicate that air-sea feedback and entrainment act to damp SST anomalies while Ekman pumping has a negligible effect on mixed-layer depth and SST anomalies in midatitudes.« less

Forecasting decadal changes in sea surface temperatures and coral bleaching within a Caribbean coral reef

NASA Astrophysics Data System (ADS)

Li, Angang; Reidenbach, Matthew A.

2014-09-01

Elevated sea surface temperature (SST) caused by global warming is one of the major threats to coral reefs. While increased SST has been shown to negatively affect the health of coral reefs by increasing rates of coral bleaching, how changes to atmospheric heating impact SST distributions, modified by local flow environments, has been less understood. This study aimed to simulate future water flow patterns and water surface heating in response to increased air temperature within a coral reef system in Bocas del Toro, Panama, located within the Caribbean Sea. Water flow and SST were modeled using the Delft3D-FLOWcomputer simulation package. Locally measured physical parameters, including bathymetry, astronomic tidal forcing, and coral habitat distribution were input into the model and water flow, and SST was simulated over a four-month period under present day, as well as projected warming scenarios in 2020s, 2050s, and 2080s. Changes in SST, and hence the thermal stress to corals, were quantified by degree heating weeks. Results showed that present-day reported bleaching sites were consistent with localized regions of continuous high SST. Regions with highest SST were located within shallow coastal sites adjacent to the mainland or within the interior of the bay, and characterized by low currents with high water retention times. Under projected increases in SSTs, shallow reef areas in low flow regions were found to be hot spots for future bleaching.

Novel, potent, and radio-iodinatable somatostatin receptor 1 (sst1) selective analogues.

PubMed

Erchegyi, Judit; Cescato, Renzo; Grace, Christy Rani R; Waser, Beatrice; Piccand, Véronique; Hoyer, Daniel; Riek, Roland; Rivier, Jean E; Reubi, Jean Claude

2009-05-14

The proposed sst(1) pharmacophore (J. Med. Chem. 2005, 48, 523-533) derived from the NMR structures of a family of mono- and dicyclic undecamers was used to design octa-, hepta-, and hexamers with high affinity and selectivity for the somatostatin sst(1) receptor. These compounds were tested for their in vitro binding properties to all five somatostatin (SRIF) receptors using receptor autoradiography; those with high SRIF receptor subtype 1 (sst(1)) affinity and selectivity were shown to be agonists when tested functionally in a luciferase reporter gene assay. Des-AA(1,4-6,10,12,13)-[DTyr(2),DAgl(NMe,2naphthoyl)(8),IAmp(9)]-SRIF-Thr-NH(2) (25) was radio-iodinated ((125)I-25) and specifically labeled sst(1)-expressing cells and tissues. 3D NMR structures were calculated for des-AA(1,4-6,10,12,13)-[DPhe(2),DTrp(8),IAmp(9)]-SRIF-Thr-NH(2) (16), des-AA(1,2,4-6,10,12,13)-[DAgl(NMe,2naphthoyl)(8),IAmp(9)]-SRIF-Thr-NH(2) (23), and des-AA(1,2,4-6,10,12,13)-[DAgl(NMe,2naphthoyl)(8),IAmp(9),Tyr(11)]-SRIF-NH(2) (27) in DMSO. Though the analogues have the sst(1) pharmacophore residues at the previously determined distances from each other, the positioning of the aromatic residues in 16, 23, and 27 is different from that described earlier, suggesting an induced fit mechanism for sst(1) binding of these novel, less constrained sst(1)-selective family members.

Novel receptor-targeted contrast agents for optical imaging of tumors

NASA Astrophysics Data System (ADS)

Becker, Andreas; Hessenius, Carsten; Bhargava, Sarah; Ebert, Bernd; Sukowski, Uwe; Rinneberg, Herbert H.; Wiedenmann, Bertram; Semmler, Wolfhard; Licha, Kai

2000-04-01

Many gastroenteropancreatic tumors express receptors for somatostatin (SST) and/or vasoactive intestinal peptide (VIP). These receptors can be used as molecular targets for the delivery of contrast agents for tumor diagnostics. We have synthesized conjugates consisting of a cyanine dye and an SST analogue or VIP for use as contrast agents in optical imaging. Receptor binding and internalization of these compounds were examined with optical methods in transfected RIN38 tumor cells expressing the SST2 receptor or a GFP- labeled VIP (VPAC1) receptor. Furthermore, biodistribution of the conjugates was examined by laser-induced fluorescence imaging in nude mice bearing SST2 or VPAC1 receptor- expressing tumors. After incubation of RIN38 SSTR2 cells in the presence of 100 nM indotricarbocyanine-SST analogue, cell-associated fluorescence increased, whereas no increase was observed when receptor-medicated endocytosis was inhibited. Indodicarbocyanine-VIP accumulated in RIN38 VPAC1 cells and co-localization with the GFP-labeled VPAC1 receptor was observed. After injection of indotricarbocyanine-SST analogue into tumor-bearing nude mice, SST2 receptor-positive tumors could be visualized for a time period from 10 min to at least 48 h. After application of indodicarbocyanine-VIP, a fluorescence signal in VIP1 receptor-expressing tumors was only detected during the first hour. We conclude that cyanine dye-labeled VIP and SST analogue are novel, targeted contrast agents for the optical imaging of tumors expressing the relevant receptor.

Superior Rhythm Discrimination With the SmartShock Technology Algorithm　- Results of the Implantable Defibrillator With Enhanced Features and Settings for Reduction of Inaccurate Detection (DEFENSE) Trial.

PubMed

Oginosawa, Yasushi; Kohno, Ritsuko; Honda, Toshihiro; Kikuchi, Kan; Nozoe, Masatsugu; Uchida, Takayuki; Minamiguchi, Hitoshi; Sonoda, Koichiro; Ogawa, Masahiro; Ideguchi, Takeshi; Kizaki, Yoshihisa; Nakamura, Toshihiro; Oba, Kageyuki; Higa, Satoshi; Yoshida, Keiki; Tsunoda, Soichi; Fujino, Yoshihisa; Abe, Haruhiko

2017-08-25

Shocks delivered by implanted anti-tachyarrhythmia devices, even when appropriate, lower the quality of life and survival. The new SmartShock Technology ® (SST) discrimination algorithm was developed to prevent the delivery of inappropriate shock. This prospective, multicenter, observational study compared the rate of inaccurate detection of ventricular tachyarrhythmia using the SST vs. a conventional discrimination algorithm.Methods and Results:Recipients of implantable cardioverter defibrillators (ICD) or cardiac resynchronization therapy defibrillators (CRT-D) equipped with the SST algorithm were enrolled and followed up every 6 months. The tachycardia detection rate was set at ≥150 beats/min with the SST algorithm. The primary endpoint was the time to first inaccurate detection of ventricular tachycardia (VT) with conventional vs. the SST discrimination algorithm, up to 2 years of follow-up. Between March 2012 and September 2013, 185 patients (mean age, 64.0±14.9 years; men, 74%; secondary prevention indication, 49.5%) were enrolled at 14 Japanese medical centers. Inaccurate detection was observed in 32 patients (17.6%) with the conventional, vs. in 19 patients (10.4%) with the SST algorithm. SST significantly lowered the rate of inaccurate detection by dual chamber devices (HR, 0.50; 95% CI: 0.263-0.950; P=0.034). Compared with previous algorithms, the SST discrimination algorithm significantly lowered the rate of inaccurate detection of VT in recipients of dual-chamber ICD or CRT-D.

The accuracy of SST retrievals from AATSR: An initial assessment through geophysical validation against in situ radiometers, buoys and other SST data sets

NASA Astrophysics Data System (ADS)

Corlett, G. K.; Barton, I. J.; Donlon, C. J.; Edwards, M. C.; Good, S. A.; Horrocks, L. A.; Llewellyn-Jones, D. T.; Merchant, C. J.; Minnett, P. J.; Nightingale, T. J.; Noyes, E. J.; O'Carroll, A. G.; Remedios, J. J.; Robinson, I. S.; Saunders, R. W.; Watts, J. G.

The Advanced Along-Track Scanning Radiometer (AATSR) was launched on Envisat in March 2002. The AATSR instrument is designed to retrieve precise and accurate global sea surface temperature (SST) that, combined with the large data set collected from its predecessors, ATSR and ATSR-2, will provide a long term record of SST data that is greater than 15 years. This record can be used for independent monitoring and detection of climate change. The AATSR validation programme has successfully completed its initial phase. The programme involves validation of the AATSR derived SST values using in situ radiometers, in situ buoys and global SST fields from other data sets. The results of the initial programme presented here will demonstrate that the AATSR instrument is currently close to meeting its scientific objectives of determining global SST to an accuracy of 0.3 K (one sigma). For night time data, the analysis gives a warm bias of between +0.04 K (0.28 K) for buoys to +0.06 K (0.20 K) for radiometers, with slightly higher errors observed for day time data, showing warm biases of between +0.02 (0.39 K) for buoys to +0.11 K (0.33 K) for radiometers. They show that the ATSR series of instruments continues to be the world leader in delivering accurate space-based observations of SST, which is a key climate parameter.

Soluble ST2 Plasma Concentrations Predict Mortality in HBV-Related Acute-on-Chronic Liver Failure

PubMed Central

Mo, Zhishuo; Zhu, Jianyun; Pang, Xiuqing; Wu, Zhebin; Wang, Ke; Li, Xinhua; Xie, Dongying; Gao, Zhiliang

2015-01-01

Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a rapidly progressing and frequently fatal condition. The aim of this study was to determine whether interleukin- (IL-) 33 and soluble ST2 (sST2) were associated with disease severity and mortality in HBV-ACLF. We found that plasma levels of sST2 but not IL-33 were higher in HBV-ACLF patients compared with chronic hepatitis B (CHB) patients and healthy controls. However, plasma levels of IL-33, TNF-α, IFN-γ, and IL-10 did not correlate with sST2 levels. Similarly, immunohistochemistry revealed low IL-33 expression and high ST2 expression in liver sections of patients with HBV-ACLF. Evaluation of dynamic changes of sST2 in HBV-ACLF showed that plasma sST2 levels increased over time in patients who died during the 180-day follow-up but decreased in those who survived. In addition, plasma sST2 level after week 1 correlated with disease severity, as assessed by total bilirubin, prothrombin time, and model for end-stage liver disease score. Results of Kaplan-Meier survival analysis showed that higher sST2 concentration (≥87 ng/mL) at week 3 was associated with poor survival. These findings indicate the potential usefulness of sST2 as a predictor of disease severity and in making treatment decisions for patients with HBV-ACLF. PMID:25892854

Potential predictability and actual skill of Boreal Summer Tropical SST and Indian summer monsoon rainfall in CFSv2-T382: Role of initial SST and teleconnections

NASA Astrophysics Data System (ADS)

Pillai, Prasanth A.; Rao, Suryachandra A.; Das, Renu S.; Salunke, Kiran; Dhakate, Ashish

2017-10-01

The present study assess the potential predictability of boreal summer (June through September, JJAS) tropical sea surface temperature (SST) and Indian summer monsoon rainfall (ISMR) using high resolution climate forecast system (CFSv2-T382) hindcasts. Potential predictability is computed using relative entropy (RE), which is the combined effect of signal strength and model spread, while the correlation between ensemble mean and observations represents the actual skill. Both actual and potential skills increase as lead time decreases for Niño3 index and equatorial East Indian Ocean (EEIO) SST anomaly and both the skills are close to each other for May IC hindcasts at zero lead. At the same time the actual skill of ISMR and El Niño Modoki index (EMI) are close to potential skill for Feb IC hindcasts (3 month lead). It is interesting to note that, both actual and potential skills are nearly equal, when RE has maximum contribution to individual year's prediction skill and its relationship with absolute error is insignificant or out of phase. The major contribution to potential predictability is from ensemble mean and the role of ensemble spread is limited for Pacific SST and ISMR hindcasts. RE values are able to capture the predictability contribution from both initial SST and simultaneous boundary forcing better than ensemble mean, resulting in higher potential skill compared to actual skill for all ICs. For Feb IC hindcasts at 3 month lead time, initial month SST (Feb SST) has important predictive component for El Niño Modoki and ISMR leading to higher value of actual skill which is close to potential skill. This study points out that even though the simultaneous relationship between ensemble mean ISMR and global SST is similar for all ICs, the predictive component from initial SST anomalies are captured well by Feb IC (3 month lead) hindcasts only. This resulted in better skill of ISMR for Feb IC (3 month lead) hindcasts compared to May IC (0 month lead) hindcasts. Lack of proper contribution from initial SST and teleconnections induces large absolute error for ISMR in May IC hindcasts resulting in very low actual skill. Thus the use of potential predictability skill and actual skill collectively help to understand the fidelity of the model for further improvement by differentiating the role of initial SST and simultaneous boundary forcing to some extent.

Climatic teleconnections between the subtropical and polar North Atlantic during the Last Interglacial period (MIS5e)

NASA Astrophysics Data System (ADS)

Bauch, H. A.; Zhuravleva, A.

2017-12-01

Meridional gradients in sea surface temperature (SST) control ocean-atmosphere circulation patterns and, thus, regulate the global climate. Here we reconstruct variability of these gradients in the course of the Last Interglacial (MIS5e), by using sediment records from the low and high latitude North Atlantic which are linked via the Gulf Stream.In the Nordic Seas, i.e., at the northern end of the Gulf Stream extension, strong post-Saalian meltwater discharge reduced northward-directed transport of surface oceanic heat until the mid-MIS5e, resulting in a late and rather weak SST peak. To decipher the corresponding climatic changes in the area of the Gulf Stream origin, we employ stable isotopes data, planktic foraminifera assemblages as well as a new alkenone paleotemperature record from core drilled on the upper northern slope of the Little Bahama Bank. In addition, chemical composition of sediments (XRF data) was used to asses past sea level fluctuations and sedimentation regimes on this shallow-water carbonate bank. Significant variations in Sr/Ca ratios point to a two-fold structure of the Last Interglacial. Stabilized Sr/Ca values were reached only during the second phase of MIS5e, possibly representing the interval of maximum bank-top flooding after the northern hemisphere deglaciation terminated. Faunal-based proxies as well as oxygen isotopic gradients between surface and bottom-dwelling foraminifera corroborate existence of the two major climatic phases within the Last Interglacial, in agreement with the respective development in the polar region. This further suggests a strong climatic coupling between the subtropical and high-latitude North Atlantic with important implications for meridional SST gradients during the Last Interglacial.

Influence of Kuroshio Oceanic Eddies on North Pacific Weather Patterns

NASA Astrophysics Data System (ADS)

Ma, X.; Chang, P.; Saravanan, R.; Montuoro, R.; Hsieh, J. S.; Wu, D.; Lin, X.; Wu, L.; Jing, Z.

2016-02-01

High-resolution satellite observations reveal energetic meso-scale ocean eddy activity and positive correlation between meso-scale sea surface temperature (SST) and surface wind along oceanic frontal zones, such as the Kuroshio and Gulf Stream, suggesting a potential role of meso-scale oceanic eddies in forcing the atmosphere. Using a 27 km horizontal resolution Weather Research Forecasting (WRF) model forced with observed daily SST at 0.09° spatial resolution during boreal winter season, two ensembles of 10 WRF simulations, in one of which meso-scale SST variability induced by ocean eddies was suppressed, were conducted in the North Pacific to study the local and remote influence of meso-scale oceanic eddies in the Kuroshio Extention Region (KER) on the atmosphere. Suppression of meso-scale oceanic eddies results in a deep tropospheric response along and downstream of the KER, including a significant decrease (increase) in winter season mean rainfall along the KER (west coast of US), a reduction of storm genesis in the KER, and a southward shift of the jet stream and North Pacific storm track in the eastern North Pacific. The simulated local and remote rainfall response to meso-scale oceanic eddies in the KER is also supported by observational analysis. A mechanism invoking moist baroclinic instability is proposed as a plausible explanation for the linkage between meso-scale oceanic eddies in the KER and large-scale atmospheric response in the North Pacific. It is argued that meso-scale oceanic eddies can have a rectified effect on planetary boundary layer moisture, the stability of the lower atmosphere and latent heat release, which in turn affect cyclogenesis. The accumulated effect of the altered storm development downstream further contributes to the equivalent barotropic mean flow change in the eastern North Pacific basin.

Climate Variability and Oceanographic Settings Associated with Interannual Variability in the Initiation of Dinophysis acuminata Blooms

PubMed Central

Díaz, Patricio A.; Reguera, Beatriz; Ruiz-Villarreal, Manuel; Pazos, Yolanda; Velo-Suárez, Lourdes; Berger, Henrick; Sourisseau, Marc

2013-01-01

In 2012, there were exceptional blooms of D. acuminata in early spring in what appeared to be a mesoscale event affecting Western Iberia and the Bay of Biscay. The objective of this work was to identify common climatic patterns to explain the observed anomalies in two important aquaculture sites, the Galician Rías Baixas (NW Spain) and Arcachon Bay (SW France). Here, we examine climate variability through physical-biological couplings, Sea Surface Temperature (SST) anomalies and time of initiation of the upwelling season and its intensity over several decades. In 2012, the mesoscale features common to the two sites were positive anomalies in SST and unusual wind patterns. These led to an atypical predominance of upwelling in winter in the Galician Rías, and increased haline stratification associated with a southward advection of the Gironde plume in Arcachon Bay. Both scenarios promoted an early phytoplankton growth season and increased stability that enhanced D. acuminata growth. Therefore, a common climate anomaly caused exceptional blooms of D. acuminata in two distant regions through different triggering mechanisms. These results increase our capability to predict intense diarrhetic shellfish poisoning outbreaks in the early spring from observations in the preceding winter. PMID:23959151

Fine Structure and Dynamics of Sunspot Penumbra

NASA Astrophysics Data System (ADS)

Ryutova, M.; Berger, T.; Title, A.

2007-08-01

A mature sunspot is usually surrounded by a penumbra: strong vertical magnetic field in the umbra, the dark central region of sunspot, becomes more and more horizontal toward the periphery forming an ensemble of a thin magnetic filaments of varying inclinations. Recent high resolution observations with the 1-meter Swedish Solar Telescope (SST) on La Palma revealed a fine substructure of penumbral filaments and new regularities in their dynamics.1 These findings provide both the basis and constraints for an adequate model of the penumbra whose origin still remains enigmatic. We present results of recent observations obtained with the SST. Our data, taken simultaneously in 4305 Å G-band and 4396 Å continuum bandpasses and compiled in high cadence movies, confirm previous results and reveal new features of the penumbra. We find e.g. that individual filaments are cylindrical helices with a pitch/radius ratio providing their dynamic stability. We propose a mechanism that may explain the fine structure of penumbral filaments, the observed regularities, and their togetherness with sunspot formation. The mechanism is based on the anatomy of sunspots in which not only penumbra has a filamentary structure but umbra itself is a dense conglomerate of twisted interlaced flux tubes.

Indo-Pacific ENSO modes in a double-basin Zebiak-Cane model

NASA Astrophysics Data System (ADS)

Wieners, Claudia; de Ruijter, Will; Dijkstra, Henk

2016-04-01

We study Indo-Pacific interactions on ENSO timescales in a double-basin version of the Zebiak-Cane ENSO model, employing both time integrations and bifurcation analysis (continuation methods). The model contains two oceans (the Indian and Pacific Ocean) separated by a meridional wall. Interaction between the basins is possible via the atmosphere overlaying both basins. We focus on the effect of the Indian Ocean (both its mean state and its variability) on ENSO stability. In addition, inspired by analysis of observational data (Wieners et al, Coherent tropical Indo-Pacific interannual climate variability, in review), we investigate the effect of state-dependent atmospheric noise. Preliminary results include the following: 1) The background state of the Indian Ocean stabilises the Pacific ENSO (i.e. the Hopf bifurcation is shifted to higher values of the SST-atmosphere coupling), 2) the West Pacific cooling (warming) co-occurring with El Niño (La Niña) is essential to simulate the phase relations between Pacific and Indian SST anomalies, 3) a non-linear atmosphere is needed to simulate the effect of the Indian Ocean variability onto the Pacific ENSO that is suggested by observations.

Beyond the Illusion of Symmetry: How to Think about Arms Control

DTIC Science & Technology

1988-05-01

Proliferation Treaty of 1970, the ABM Treaty of 1972 and the SALT I Interim Offensive Agreement of 1972. (48:206) It is significant to point out as Joe...34destabilizing" aspects of the ABM system. (76:222) These are the fundamental principles of the next phase of arms control. The SALT Negotiations As...Emerging Soviet capabilities plus ABM and MIRV technologies seriously threatened strategic stability. As the Soviet jnion achieved strategic parity with

Interim Scientific Report, Air Force Grant AFOSR-82-0238, 1 June 1982-31 March 1983,

DTIC Science & Technology

1983-03-31

research, may be found in the dissertation of RIBERA . Other publications are mainly those of the Principal Investigator (see KALMAN [1983, 1982a...doctoral student (now at Marmora Scientific and Industrial Research Institute, Docaeli, TURKEY). Dr. J. Ribera , doctoral student (now on faculty of IESE...stability", Ph. D. dissertation, University of Florida, 63 pages. J. RIBERA (1982] "Identification of linear relations from noisy data", Ph. D. dissertation

Finite cell lines of turkey sperm storage tubule cells: ultrastructure and protein analysis

USDA-ARS?s Scientific Manuscript database

Cell lines of turkey sperm storage tubule (SST) epithelial cells were established. Turkey SSTs were dissected from freshly obtained uterovaginal junction (UVJ) tissue and placed in explants culture on various substrates and media. Primary cultures of SST epithelium only survived and grew from SST ex...

NCEP SST Analysis

Science.gov Websites

Branches Global Climate & Weather Modeling Mesoscale Modeling Marine Modeling and Analysis Contact EMC , state and local government Web resources and services. Real-time, global, sea surface temperature (RTG_SST_HR) analysis For a regional map, click the desired area in the global SST analysis and anomaly maps

Modern technology for landfill waste placement

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hansen, D.L.

1995-12-31

The City of Albany, New York, together with the principals of Landfill Service Corporation, proposed in November 1991 to demonstrate the successful practice of biostabilized solid waste placement in the newly constructed, double composite lined Interim Landfill located at Rapp Road in the City of Albany. This is a small facility, only 12 acres in area, which is immediately adjacent to residential neighbors. Significant advancements have been made for the control of environmental factors (odors, vectors, litter) while successfully achieving waste stabilization and air space conservations goals. Also, the procedure consumes a significant quantity of landfill leachate. The benefits ofmore » this practice include a dramatic improvement in the orderlines of waste placement with significant reduction of windblown dust and litter. The biostabilization process also reduces the presence of typical landfill vectors such as flies, crows, seagulls and rodents. All of these factors can pose serious problems for nearby residents to the City of Albany`s Interim landfill site. The physically and biologically uniform character of the stabilized waste mass can result in more uniform future landfill settlement and gas production properties. This can allow for more accurate prediction of postclosure conditions and reduction or elimination of remedial costs attendant to post closure gross differential settlement. Recent research in Europe indicates that aerobic pretreatment of waste also reduces contaminant loading of leachate.« less

Self-System Therapy for Distress Associated with Persistent Low Back Pain: A Randomized Clinical Trial

PubMed Central

Waters, Sandra J.; McKee, Daphne C.; Campbell, Lisa C.; Shelby, Rebecca A.; Dixon, Kim E.; Fras, Anne Marie; Keefe, Francis J.

2015-01-01

Objective Persistent low back pain (PLBP) is associated with vulnerability to depression. PLBP frequently requires major changes in occupation and lifestyle, which can lead to a sense of failing to attain one’s personal goals (self-discrepancy). Method We conducted a clinical trial to examine the efficacy of self-system therapy (SST), a brief structured therapy for depression based on self-discrepancy theory. A total of 101 patients with PLBP and clinically significant depressive symptoms were randomized either to SST, pain education, or standard care. Results Patients receiving SST showed significantly greater improvement in depressive symptoms. Reduction in self-discrepancy predicted reduction in depressive symptoms only within the SST condition. Conclusions Findings support the utility of SST for individuals facing persistent pain and associated depression. PMID:26079438

Heat flux exchange estimation by using ATSR SST data in TOGA area

NASA Astrophysics Data System (ADS)

Xue, Yong; Lawrence, Sean P.; Llewellyn-Jones, David T.

1995-12-01

The study of phenomena such as ENSO requires consideration of the dynamics and thermodynamics of the coupled ocean-atmosphere system. The dynamic and thermal properties of the atmosphere and ocean are directly affected by air-sea transfers of fluxes of momentum, heat and moisture. In this paper, we present results of turbulent heat fluxes calculated by using two years (1992 and 1993) monthly average TOGA data and ATSR SST data in TOGA area. A comparison with published results indicates good qualitative agreement. Also, we compared the results of heat flux exchange by using ATSR SST data and by using the TOGA bucket SST data. The ATSR SST data set has been shown to be useful in helping to estimate the large space scale heat flux exchange.

Assimilation for skin SST in the NASA GEOS atmospheric data assimilation system.

PubMed

Akella, Santha; Todling, Ricardo; Suarez, Max

2017-01-01

The present article describes the sea surface temperature (SST) developments implemented in the Goddard Earth Observing System, Version 5 (GEOS-5) Atmospheric Data Assimilation System (ADAS). These are enhancements that contribute to the development of an atmosphere-ocean coupled data assimilation system using GEOS. In the current quasi-operational GEOS-ADAS, the SST is a boundary condition prescribed based on the OSTIA product, therefore SST and skin SST (Ts) are identical. This work modifies the GEOS-ADAS Ts by modeling and assimilating near sea surface sensitive satellite infrared (IR) observations. The atmosphere-ocean interface layer of the GEOS atmospheric general circulation model (AGCM) is updated to include near surface diurnal warming and cool-skin effects. The GEOS analysis system is also updated to directly assimilate SST-relevant Advanced Very High Resolution Radiometer (AVHRR) radiance observations. Data assimilation experiments designed to evaluate the Ts modification in GEOS-ADAS show improvements in the assimilation of radiance observations that extends beyond the thermal IR bands of AVHRR. In particular, many channels of hyperspectral sensors, such as those of the Atmospheric Infrared Sounder (AIRS), and Infrared Atmospheric Sounding Interferometer (IASI) are also better assimilated. We also obtained improved fit to withheld, in-situ buoy measurement of near-surface SST. Evaluation of forecast skill scores show marginal to neutral benefit from the modified Ts.

Multi-species coral Sr/Ca-based sea-surface temperature reconstruction using Orbicella faveolata and Siderastrea siderea from the Florida Straits

USGS Publications Warehouse

Flannery, Jennifer A.; Richey, Julie N.; Thirumalai, Kaustubh; Poore, Richard Z.; DeLong, Kristine L.

2017-01-01

We present new, monthly-resolved Sr/Ca-based sea-surface temperature (SST) records from two species of massive coral, Orbicella faveolata and Siderastrea siderea, from the Dry Tortugas National Park, FL, USA (DTNP). We combine these new records with published data from three additional S. siderea coral colonies to generate a 278-year long multi-species stacked Sr/Ca-SST record from DTNP. The composite record of mean annual Sr/Ca-SST at DTNP shows pronounced decadal-scale variability with a range of 1 to 2°C. Notable cool intervals in the Sr/Ca-derived SST lasting about a decade centered at ~1845, ~1935, and ~1965 are associated with reduced summer Sr/Ca-SST (monthly maxima < 29°C), and imply a reduction in the spatial extent of the Atlantic Warm Pool (AWP). There is significant coherence between the composite DTNP Sr/Ca-SST record and the Atlantic Multidecadal Oscillation (AMO) index, with the AMO lagging Sr/Ca-SST at DTNP by 9 years. Low frequency variability in the Gulf Stream surface transport, which originates near DTNP, may provide a link for the lagged relationship between multidecadal variability at DTNP and the AMO.

Development of MODIS data-based algorithm for retrieving sea surface temperature in coastal waters.

PubMed

Wang, Jiao; Deng, Zhiqiang

2017-06-01

A new algorithm was developed for retrieving sea surface temperature (SST) in coastal waters using satellite remote sensing data from Moderate Resolution Imaging Spectroradiometer (MODIS) aboard Aqua platform. The new SST algorithm was trained using the Artificial Neural Network (ANN) method and tested using 8 years of remote sensing data from MODIS Aqua sensor and in situ sensing data from the US coastal waters in Louisiana, Texas, Florida, California, and New Jersey. The ANN algorithm could be utilized to map SST in both deep offshore and particularly shallow nearshore waters at the high spatial resolution of 1 km, greatly expanding the coverage of remote sensing-based SST data from offshore waters to nearshore waters. Applications of the ANN algorithm require only the remotely sensed reflectance values from the two MODIS Aqua thermal bands 31 and 32 as input data. Application results indicated that the ANN algorithm was able to explaining 82-90% variations in observed SST in US coastal waters. While the algorithm is generally applicable to the retrieval of SST, it works best for nearshore waters where important coastal resources are located and existing algorithms are either not applicable or do not work well, making the new ANN-based SST algorithm unique and particularly useful to coastal resource management.

Somatostatin and Somatostatin Receptor Gene Expression in Dominant and Subordinate Males of an African Cichlid Fish

PubMed Central

Trainor, Brian C.; Hofmann, Hans A.

2009-01-01

Somatostatin is a neuropeptide best known for its inhibitory effects on growth hormone secretion and has recently been implicated in the control of social behavior. Several somatostatin receptor subtypes have been identified in vertebrates, but the functional basis for this diversity is still unclear. Here we investigate the expression levels of the somatostatin prepropeptide and two of its receptors, sstR2, and sstR3, in the brains of socially dominant and subordinate A. burtoni males using real-time PCR. Dominant males had higher somatostatin prepropeptide and sstR3 expression in hypothalamus compared to subordinate males. Hypothalamic sstR2 expression did not differ. There were no differences in gene expression in the telencephalon. We also observed an interesting difference between dominants and subordinates in the relationship between hypothalamic sstR2 expression and body size. As would be predicted based on the inhibitory effects of somatostatin on somatic growth, sstR2 expression was negatively correlated with body size in dominant males. In contrast sstR2 expression was positively correlated with body size in subordinate males. These results suggest that somatostatin prepropeptide and receptor gene expression in the hypothalamus are associated with the control of somatic growth in A. burtoni depending on social status. PMID:17374406

Assimilation for Skin SST in the NASA GEOS Atmospheric Data Assimilation System

NASA Technical Reports Server (NTRS)

Akella, Santha; Todling, Ricardo; Suarez, Max

2017-01-01

The present article describes the sea surface temperature (SST) developments implemented in the Goddard Earth Observing System, Version 5 (GEOS) Atmospheric Data Assimilation System (ADAS). These are enhancements that contribute to the development of an atmosphere-ocean coupled data assimilation system using GEOS. In the current quasi-operational GEOS-ADAS, the SST is a boundary condition prescribed based on the OSTIA product, therefore SST and skin SST (Ts) are identical. This work modifies the GEOS-ADAS Ts by modelling and assimilating near sea surface sensitive satellite infrared (IR) observations. The atmosphere-ocean interface layer of the GEOS atmospheric general circulation model (AGCM) is updated to include near-surface diurnal warming and cool-skin effects. The GEOS analysis system is also updated to directly assimilate SST-relevant Advanced Very High Resolution Radiometer (AVHRR) radiance observations. Data assimilation experiments designed to evaluate the Ts modification in GEOS-ADAS show improvements in the assimilation of radiance observations that extend beyond the thermal infrared bands of AVHRR. In particular, many channels of hyperspectral sensors, such as those of the Atmospheric Infrared Sounder (AIRS), and Infrared Atmospheric Sounding Interferometer (IASI) are also better assimilated. We also obtained improved fit to withheld insitu buoy measurement of near-surface SST. Evaluation of forecast skill scores show neutral to marginal benefit from the modified Ts.

Optogenetic and pharmacological evidence that somatostatin-GABA neurons are important regulators of parasympathetic outflow to the stomach.

PubMed

Lewin, Amanda E; Vicini, Stefano; Richardson, Janell; Dretchen, Kenneth L; Gillis, Richard A; Sahibzada, Niaz

2016-05-15

The dorsal motor nucleus of the vagus (DMV) in the brainstem consists primarily of vagal preganglionic neurons that innervate postganglionic neurons of the upper gastrointestinal tract. The activity of the vagal preganglionic neurons is predominantly regulated by GABAergic transmission in the DMV. The present findings indicate that the overwhelming GABAergic drive present at the DMV is primarily from somatostatin positive GABA (Sst-GABA) DMV neurons. Activation of both melanocortin and μ-opioid receptors at the DMV inhibits Sst-GABA DMV neurons. Sst-GABA DMV neurons may serve as integrative targets for modulating vagal output activity to the stomach. We have previously shown that local GABA signalling in the brainstem is an important determinant of vagally-mediated gastric activity. However, the neural identity of this GABA source is currently unknown. To determine this, we focused on the somatostatin positive GABA (Sst-GABA) interneuron in the dorsal motor nucleus of the vagus (DMV), a nucleus that is intimately involved in regulating gastric activity. Also of particular interest was the effect of melanocortin and μ-opioid agonists on neural activity of Sst-GABA DMV neurons because their in vivo administration in the DMV mimics GABA blockade in the nucleus. Experiments were conducted in brain slice preparation of transgenic adult Sst-IRES-Cre mice expressing tdTomato fluorescence, channelrhodopsin-2, archaerhodopsin or GCaMP3. Electrophysiological recordings were obtained from Sst-GABA DMV neurons or DiI labelled gastric-antrum projecting DMV neurons. Our results show that optogenetic stimulation of Sst-GABA neurons results in a robust inhibition of action potentials of labelled premotor DMV neurons to the gastric-antrum through an increase in inhibitory post-synaptic currents. The activity of the Sst-GABA neurons in the DMV is inhibited by both melanocortin and μ-opioid agonists. These agonists counteract the pronounced inhibitory effect of Sst-GABA neurons on vagal pre-motor neurons in the DMV that control gastric motility. These observations demonstrate that Sst-GABA neurons in the brainstem are crucial for regulating the activity of gastric output neurons in the DMV. Additionally, they suggest that these neurons serve as targets for converging CNS signals to regulate parasympathetic gastric function. © 2016 The Authors. The Journal of Physiology © 2016 The Physiological Society.

Evaluation of Enhanced High Resolution MODIS/AMSR-E SSTs and the Impact on Regional Weather Forecast

NASA Technical Reports Server (NTRS)

Schiferl, Luke D.; Fuell, Kevin K.; Case, Jonathan L.; Jedlovec, Gary J.

2010-01-01

Over the last few years, the NASA Short-term Prediction Research and Transition (SPoRT) Center has been generating a 1-km sea surface temperature (SST) composite derived from retrievals of the Moderate Resolution Imaging Spectroradiometer (MODIS) for use in operational diagnostics and regional model initialization. With the assumption that the day-to-day variation in the SST is nominal, individual MODIS passes aboard the Earth Observing System (EOS) Aqua and Terra satellites are used to create and update four composite SST products each day at 0400, 0700, 1600, and 1900 UTC, valid over the western Atlantic and Caribbean waters. A six month study from February to August 2007 over the marine areas surrounding southern Florida was conducted to compare the use of the MODIS SST composite versus the Real-Time Global SST analysis to initialize the Weather Research and Forecasting (WRF) model. Substantial changes in the forecast heat fluxes were seen at times in the marine boundary layer, but relatively little overall improvement was measured in the sensible weather elements. The limited improvement in the WRF model forecasts could be attributed to the diurnal changes in SST seen in the MODIS SST composites but not accounted for by the model. Furthermore, cloud contamination caused extended periods when individual passes of MODIS were unable to update the SSTs, leading to substantial SST latency and a cool bias during the early summer months. In order to alleviate the latency problems, the SPoRT Center recently enhanced its MODIS SST composite by incorporating information from the Advanced Microwave Scanning Radiometer-EOS (AMSR-E) instruments as well as the Operational Sea Surface Temperature and Sea Ice Analysis. These enhancements substantially decreased the latency due to cloud cover and improved the bias and correlation of the composites at available marine point observations. While these enhancements improved upon the modeled cold bias using the original MODIS SSTs, the discernable impacts on the WRF model were still somewhat limited. This paper explores several factors that may have contributed to this result. First, the original methodology to initialize the model used the most recent SST composite available in a hypothetical real ]time configuration, often matching the forecast initial time with an SST field that was 5-8 hours offset. To minimize the differences that result from the diurnal variations in SST, the previous day fs SST composite is incorporated at a time closest to the model initialization hour (e.g. 1600 UTC composite at 1500 UTC model initialization). Second, the diurnal change seen in the MODIS SST composites was not represented by the WRF model in previous simulations, since the SSTs were held constant throughout the model integration. To address this issue, we explore the use of a water skin-temperature diurnal cycle prediction capability within v3.1 of the WRF model to better represent fluctuations in marine surface forcing. Finally, the verification of the WRF model is limited to very few over-water sites, many of which are located near the coastlines. In order to measure the open ocean improvements from the AMSR-E, we could use an independent 2-dimensional, satellite-derived data set to validate the forecast model by applying an object-based verification method. Such a validation technique could aid in better understanding the benefits of the mesoscale SST spatial structure to regional models applications.

Solid-state dosimeters: A new approach for mammography measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brateman, Libby F., E-mail: bratel@radiology.ufl.edu; Heintz, Philip H.

2015-02-15

Purpose: To compare responses of modern commercially available solid-state dosimeters (SStDs) used in mammography medical physics surveys for two major vendors of current digital mammography units. To compare differences in dose estimates among SStD responses with ionization chamber (IC) measurements for several target/filter (TF) combinations and report their characteristics. To review scientific bases for measurements of quantities required for mammography for traditional measurement procedures and SStDs. Methods: SStDs designed for use with modern digital mammography units were acquired for evaluation from four manufacturers. Each instrument was evaluated under similar conditions with the available mammography beams provided by two modern full-fieldmore » digital mammography units in clinical use: a GE Healthcare Senographe Essential (Essential) and a Hologic Selenia Dimensions 5000 (Dimensions), with TFs of Mo/Mo, Mo/Rh; and Rh/Rh and W/Rh, W/Ag, and W/Al, respectively. Measurements were compared among the instruments for the TFs over their respective clinical ranges of peak tube potentials for kVp and half-value layer (HVL) measurements. Comparisons for air kerma (AK) and their associated relative calculated average glandular doses (AGDs), i.e., using fixed mAs, were evaluated over the limited range of 28–30 kVp. Measurements were compared with reference IC measurements for AK, reference HVLs and calculated AGD, for two compression paddle heights for AK, to evaluate scatter effects from compression paddles. SStDs may require different positioning from current mammography measurement protocols. Results: Measurements of kVp were accurate in general for the SStDs (within −1.2 and +1.1 kVp) for all instruments over a wide range of set kVp’s and TFs and most accurate for Mo/Mo and W/Rh. Discrepancies between measurements and reference values were greater for HVL and AK. Measured HVL values differed from reference values by −6.5% to +3.5% depending on the SStD and TF. AK measurements over limited (28–30) kVp’s ranged from −6% to +7% for SStDs, compared with IC reference values. Relative AGDs for each SStD using its associated measurements of kVp, HVL and AK underestimated AGD in nearly all cases, compared with reference IC values, with discrepancies of <−1% to ∼−10%. Some differences in AGD were related to differences in contributions of compression paddle scatter to AK measurements made by ICs. Applying measured factors for scatter effects in AK measurements for three SStDs reduced discrepancies between −6.2% and +1.3%, shifting AGDs from SStDs closer to IC AGDs. Conclusions: This study revealed that SStD measurements yielded good agreement with set kVp, poor agreement with standard HVL determinations, and AK measurements that were substantially different from IC measurements. Discrepancies are partly related to the scattered radiation measured by ICs in determining AK. As a result, IC measurements required for AGD, using currently accepted methodology, typically result in higher AGDs than SStDs, because current methodologies do not account for differing instrument responses to scatter. HVLs reported by SStDs contribute to discrepancies in calculated AGD that depend on kVp and TF. Medical physicists are encouraged to compare their results for SStD instruments using a similar methodology for potential discrepancies with their traditional instruments.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xue, Yongkang; De Sales, Fernando; Lau, William K. -M.

The Sahel climate system had experienced one of the strongest interdecadal climate variabilities and the longest drought on the planet in the twentieth century. Most modeling studies on the decadal variability of the Sahel climate so far have focused on the role of anomalies in either sea surface temperature (SST), land surface processes, or aerosols concentration. The Second West African Monsoon Modeling and Evaluation Project Experiment (WAMME II) is designed to improve understanding of the possible roles and feedback of SST, land use land cover change (LULCC), and aerosols forcings in the Sahel climate system at seasonal to decadal scales.more » The WAMME II strategy is to apply observationally based anomaly forcing, i.e., “idealized but realistic” forcing, in simulations by general circulation models’ (GCMs) and regional climate models’ (RCMs) to test the relative impacts of such forcings in producing/amplifying the Sahelian seasonal and decadal climate variability, including the 20th century drought. To test individual ocean’s SST effect, a special approach in the experimental design is taken to avoid undermine its effect. This is the first multi-model experiment specifically designed to simultaneously evaluate relative contributions of multiple-external forcings to the Sahel drought. This paper presents the major results and preliminary findings of the WAMME II SST experiment, including each ocean’s contribution to the global SST effect, as well as comparison of the SST effect with the LULCC effect. The common empirical orthogonal functions and other analyses are applied to assess and comprehend the discrepancies among the models. In general, the WAMME II models have reached a consensus on SST’s major contribution to the great Sahel drought and show that with the maximum possible SST forcing, it can produce up to 60% of the absolute amount of precipitation difference between the 1980s and the 1950s. This paper has 3 also delineated the role of SSTs in triggering and maintaining the Sahel drought, suggesting a potential predictability of WAM development linked to SST. Among different ocean basins, the Pacific and Indian Ocean SSTs have the greatest impact on the 1980s drought. The WAMME II, however, fails to reach a consensus on the role of the Mediterranean Sea SST. The changes in circulation, moisture flux convergence, and associated surface energy balances are the main mechanisms for the SST effect. The paper also compares the SST effect with the LULCC effects. It is shown that the prescribed land forcing produces about 40% of the precipitation difference between the 1980s and the 1950s, which is less than SST contribution but still of first order in the Sahel climate system. The role of land surface processes in responding to and amplifying the drought has also been identified. The results demonstrate that catastrophic consequences likely occur in the regional climate when SST anomalies in individual ocean basins and in land conditions combine synergistically to favor drought. Due to limited ensemble members, aerosol effects are not compared. Since the SST and land forcing in the real world are likely smaller than specified in this study, further investigations on the effects of aerosols as well as of other external forcings, such as greenhouse gases, and of atmospheric internal variability, are necessary. Moreover, although the WAMEE II models support a general consensus on SST and LULCC effects, there are still large discrepancies in how these models produce the Sahel drought in the 1980s. Better atmospheric observational and analysis data including more processes and components are necessary to validate and constrain models, and to guide further model development and improvement.« less

Decadal variability of the Tropical Atlantic Ocean Surface Temperature in shipboard measurements and in a Global Ocean-Atmosphere model

NASA Technical Reports Server (NTRS)

Mehta, Vikram M.; Delworth, Thomas

1995-01-01

Sea surface temperature (SST) variability was investigated in a 200-yr integration of a global model of the coupled oceanic and atmospheric general circulations developed at the Geophysical Fluid Dynamics Laboratory (GFDL). The second 100 yr of SST in the coupled model's tropical Atlantic region were analyzed with a variety of techniques. Analyses of SST time series, averaged over approximately the same subregions as the Global Ocean Surface Temperature Atlas (GOSTA) time series, showed that the GFDL SST anomalies also undergo pronounced quasi-oscillatory decadal and multidecadal variability but at somewhat shorter timescales than the GOSTA SST anomalies. Further analyses of the horizontal structures of the decadal timescale variability in the GFDL coupled model showed the existence of two types of variability in general agreement with results of the GOSTA SST time series analyses. One type, characterized by timescales between 8 and 11 yr, has high spatial coherence within each hemisphere but not between the two hemispheres of the tropical Atlantic. A second type, characterized by timescales between 12 and 20 yr, has high spatial coherence between the two hemispheres. The second type of variability is considerably weaker than the first. As in the GOSTA time series, the multidecadal variability in the GFDL SST time series has approximately opposite phases between the tropical North and South Atlantic Oceans. Empirical orthogonal function analyses of the tropical Atlantic SST anomalies revealed a north-south bipolar pattern as the dominant pattern of decadal variability. It is suggested that the bipolar pattern can be interpreted as decadal variability of the interhemispheric gradient of SST anomalies. The decadal and multidecadal timescale variability of the tropical Atlantic SST, both in the actual and in the GFDL model, stands out significantly above the background 'red noise' and is coherent within each of the time series, suggesting that specific sets of processes may be responsible for the choice of the decadal and multidecadal timescales. Finally, it must be emphasized that the GFDL coupled ocean-atmosphere model generates the decadal and multidecadal timescale variability without any externally applied force, solar or lunar, at those timescales.

A randomized controlled study of a social skills training for preadolescent children with autism spectrum disorders: generalization of skills by training parents and teachers?

PubMed Central

2014-01-01

Background Social skills training (SST) is a common intervention for children with autism spectrum disorders (ASDs) to improve their social and communication skills. Despite the fact that SSTs are often applied in clinical practice, the evidence for the effectiveness of these trainings for children with ASD is inconclusive. Moreover, long term outcome and generalization of learned skills are little evaluated. Additionally, there is no research on the influence of involvement of parents and teachers on effectiveness of SST and on the generalization of learned social skills to daily life. We expect parent and teacher involvement in SST to enhance treatment efficacy and to facilitate generalization of learned skills to daily life. Method/Design In a randomized controlled trial (RCT) with three conditions, 120 participants with ASD at the end of primary school (10–12 years of calendar age) have been randomized to SST, SST-PTI (SST with Parent & Teacher Involvement), or care-as-usual. The SST consists of 18 group sessions of 1.5 hours for the children. In the SST-PTI condition, parents additionally participate in 8 parent sessions and parents and teachers are actively involved in homework assignments. Assessment takes place at three moments: before and immediately after the intervention period and at 6 months follow-up. Primary outcome is socialization, as an aspect of adaptive functioning. Secondary outcomes focus on specific social skills children learn during SST and on more general social skills pertaining to home and community settings from a multi-informant perspective. Additionally, possible predictors of treatment outcome will be assessed. Discussion The current study is an RCT study evaluating SST in a large sample of Dutch children with ASD in a specific age range (10–12 years). Strengths of the study are the use of one manualized protocol, application of standardized and internationally used rating instruments, use of multiple raters, investigation of generalization of learned skills to daily life, and the evaluation of efficacy in the longer term by follow-up measures at 6 months after the end of training. Trial registration NTR2405 PMID:24989854

Immediate effects of different schedules of somatostatin on portal pressure in patients with liver cirrhosis.

PubMed

Zhang, C; Xu, J-M; Kong, D-R; Min, X-K; Chen, R

2013-06-01

Somatostatin (SST) is used for the treatment of acute variceal bleeding based on its ability to decrease portal pressure and collateral blood flow. To date, no studies have focused on the immediate-early effects (between 1 and 30 min) of SST. The aim of this study was to compare the efficacy of different schedules of SST therapy with placebo on portal pressure in patients with portal hypertension treated with portal-azygous disconnection and to test whether an increase in bolus or infusion dose can improve the clinical efficacy of SST therapy.   Patients were treated with four different schedules: (a) standard dose (n = 11): one 250 μg bolus + a continuous infusion of 250 μg/h; (b) medium dose (n = 10): 500 μg bolus + a continuous infusion of 250 μg/h; (c) high dose (n = 10): 250 μg bolus + a continuous infusion of 500 μg/h; (d) control (n = 10): an injection of placebo (saline) followed by a placebo infusion. Following SST or placebo administration, portal pressure, central venous pressure (CVP), systemic blood pressure and heart rate (HR) were measured at 1, 3, 5, 7, 10 and 30 min.   The three schedules of SST induced a marked, rapid and highly significant decrease in portal pressure. The decline in portal pressure was moderate at 1 min (P < 0·040), achieved a peak effect at 5 min (P < 0·009) and remained decreased at 30 min. The effect of SST on portal pressure was significantly greater than placebo from 1 min after administration. There were no significant differences in portal pressure decrease between the three schedules of SST. The three schedules of SST and the placebo schedule did not induce significant changes in HR, systemic blood pressure and CVP.   This study shows that SST is effective in decreasing portal pressure within 30 min of administration in patients with liver cirrhosis. The clinical schedule used in this study was reasonable and safe. © 2013 Blackwell Publishing Ltd.

Homologous upregulation of sst2 somatostatin receptor expression in the rat arcuate nucleus in vivo.

PubMed

Tannenbaum, G S; Turner, J; Guo, F; Videau, C; Epelbaum, J; Beaudet, A

2001-07-01

In vitro studies using various cell systems have provided conflicting results regarding homologous regulation of somatostatin (SRIH) receptors, and information on whether SRIH regulates the expression of its own receptors in vivo is lacking. In the present study we examined, by in situ hybridization, the effects of pretreatment with the sst2-preferring SRIH analog, octreotide, in vivo, on mRNA levels of two SRIH receptor subtypes, sst1 and sst2, in rat brain and pituitary. (125)I-[DTrp(8)]-SRIH binding was also measured in these regions. Three hours after the iv injection of 50 microg octreotide to conscious adult male rats, there was a 46% increase (p < 0.01) in the labeling density of sst2 mRNA-expressing cells in the hypothalamic arcuate nucleus compared to normal saline-pretreated controls, but not in any of the other brain regions examined. Computer-assisted image analysis revealed that 3 h exposure to octreotide significantly (p < 0.01) augmented both the number and labeling density of sst2 mRNA-expressing cells in the arcuate nucleus, compared to those in saline-treated controls. By contrast, within the anterior pituitary gland, in vivo exposure to octreotide did not affect the expression of sst2 mRNA. No changes in sst1 mRNA-expressing cells were observed after octreotide treatment in any of the regions measured, indicating that the observed effects were homologous, i.e. specific of the receptor subtype stimulated. Octreotide pretreatment was also without effect on the density of (125)I-[DTrp(8)]-SRIH binding in either the arcuate nucleus or pituitary. These results demonstrate, for the first time, that SRIH preexposure in vivo upregulates the expression of a subtype of its own receptors, sst2, within the central nervous system. They further suggest that pretreatment with SRIH in vivo does not cause sst2 receptor desensitization in arcuate nucleus and pituitary. Such homologous regulatory mechanisms may play an important role in the neuroendocrine control of growth hormone (GH) secretion by the arcuate nucleus. Copyright 2001 S. Karger AG, Basel

The General Circulation Model Response to a North Pacific SST Anomaly: Dependence on Time Scale and Pattern Polarity.

NASA Astrophysics Data System (ADS)

Kushnir, Yochanan; Lau, Ngar-Cheung

1992-04-01

A general circulation model was integrated with perpetual January conditions and prescribed sea surface temperature (SST) anomalies in the North Pacific. A characteristic pattern with a warm region centered northeast of Hawaii and a cold region along the western seaboard of North America was alternately added to and subtracted from the climatological SST field. Long 1350-day runs, as well as short 180-day runs, each starting from different initial conditions, were performed. The results were compared to a control integration with climatological SSTs.The model's quasi-stationary response does not exhibit a simple linear relationship with the polarity of the prescribed SST anomaly. In the short runs with a negative SST anomaly over the central ocean, a large negative height anomaly, with an equivalent barotropic vertical structure, occurs over the Gulf of Alaska. For the same SST forcing, the long run yields a different response pattern in which an anomalous high prevails over northern Canada and the Alaskan Peninsula. A significant reduction in the northward heat flux associated with baroclinic eddies and a concomitant reduction in convective heating occur along the model's Pacific storm track. In the runs with a positive SST anomaly over the central ocean, the average height response during the first 90-day period of the short runs is too weak to be significant. In the subsequent 90-day period and in the long run an equivalent barotropic low occurs downstream from the warm SST anomaly. All positive anomaly runs exhibit little change in baroclinic eddy activity or in the patterns of latent heat release. Horizontal momentum transports by baroclinic eddies appear to help sustain the quasi-stationary response in the height field regardless of the polarity of the SST anomaly. These results emphasize the important role played by baroclinic eddies in determining the quasi-stationary response to midlatitude SST anomalies. Differences between the response patterns of the short and long integrations may be relevant to future experimental design for studying air-sea interactions in the extratropies.

Analysis of Ultra High Resolution Sea Surface Temperature Level 4 Datasets

NASA Technical Reports Server (NTRS)

Wagner, Grant

2011-01-01

Sea surface temperature (SST) studies are often focused on improving accuracy, or understanding and quantifying uncertainties in the measurement, as SST is a leading indicator of climate change and represents the longest time series of any ocean variable observed from space. Over the past several decades SST has been studied with the use of satellite data. This allows a larger area to be studied with much more frequent measurements being taken than direct measurements collected aboard ship or buoys. The Group for High Resolution Sea Surface Temperature (GHRSST) is an international project that distributes satellite derived sea surface temperatures (SST) data from multiple platforms and sensors. The goal of the project is to distribute these SSTs for operational uses such as ocean model assimilation and decision support applications, as well as support fundamental SST research and climate studies. Examples of near real time applications include hurricane and fisheries studies and numerical weather forecasting. The JPL group has produced a new 1 km daily global Level 4 SST product, the Multiscale Ultrahigh Resolution (MUR), that blends SST data from 3 distinct NASA radiometers: the Moderate Resolution Imaging Spectroradiometer (MODIS), the Advanced Very High Resolution Radiometer (AVHRR), and the Advanced Microwave Scanning Radiometer ? Earth Observing System(AMSRE). This new product requires further validation and accuracy assessment, especially in coastal regions.We examined the accuracy of the new MUR SST product by comparing the high resolution version and a lower resolution version that has been smoothed to 19 km (but still gridded to 1 km). Both versions were compared to the same data set of in situ buoy temperature measurements with a focus on study regions of the oceans surrounding North and Central America as well as two smaller regions around the Gulf Stream and California coast. Ocean fronts exhibit high temperature gradients (Roden, 1976), and thus satellite data of SST can be used in the detection of these fronts. In this case, accuracy is less of a concern because the primary focus is on the spatial derivative of SST. We calculated the gradients for both versions of the MUR data set and did statistical comparisons focusing on the same regions.

A randomized controlled study of a social skills training for preadolescent children with autism spectrum disorders: generalization of skills by training parents and teachers?

PubMed

Dekker, Vera; Nauta, Maaike H; Mulder, Erik J; Timmerman, Marieke E; de Bildt, Annelies

2014-07-02

Social skills training (SST) is a common intervention for children with autism spectrum disorders (ASDs) to improve their social and communication skills. Despite the fact that SSTs are often applied in clinical practice, the evidence for the effectiveness of these trainings for children with ASD is inconclusive. Moreover, long term outcome and generalization of learned skills are little evaluated. Additionally, there is no research on the influence of involvement of parents and teachers on effectiveness of SST and on the generalization of learned social skills to daily life. We expect parent and teacher involvement in SST to enhance treatment efficacy and to facilitate generalization of learned skills to daily life. In a randomized controlled trial (RCT) with three conditions, 120 participants with ASD at the end of primary school (10-12 years of calendar age) have been randomized to SST, SST-PTI (SST with Parent & Teacher Involvement), or care-as-usual. The SST consists of 18 group sessions of 1.5 hours for the children. In the SST-PTI condition, parents additionally participate in 8 parent sessions and parents and teachers are actively involved in homework assignments. Assessment takes place at three moments: before and immediately after the intervention period and at 6 months follow-up. Primary outcome is socialization, as an aspect of adaptive functioning. Secondary outcomes focus on specific social skills children learn during SST and on more general social skills pertaining to home and community settings from a multi-informant perspective. Additionally, possible predictors of treatment outcome will be assessed. The current study is an RCT study evaluating SST in a large sample of Dutch children with ASD in a specific age range (10-12 years). Strengths of the study are the use of one manualized protocol, application of standardized and internationally used rating instruments, use of multiple raters, investigation of generalization of learned skills to daily life, and the evaluation of efficacy in the longer term by follow-up measures at 6 months after the end of training. NTR2405.

An Assessment of the Subseasonal Forecast Performance in the Extended Global Ensemble Forecast System (GEFS)

NASA Astrophysics Data System (ADS)

Sinsky, E.; Zhu, Y.; Li, W.; Guan, H.; Melhauser, C.

2017-12-01

Optimal forecast quality is crucial for the preservation of life and property. Improving monthly forecast performance over both the tropics and extra-tropics requires attention to various physical aspects such as the representation of the underlying SST, model physics and the representation of the model physics uncertainty for an ensemble forecast system. This work focuses on the impact of stochastic physics, SST and the convection scheme on forecast performance for the sub-seasonal scale over the tropics and extra-tropics with emphasis on the Madden-Julian Oscillation (MJO). A 2-year period is evaluated using the National Centers for Environmental Prediction (NCEP) Global Ensemble Forecast System (GEFS). Three experiments with different configurations than the operational GEFS were performed to illustrate the impact of the stochastic physics, SST and convection scheme. These experiments are compared against a control experiment (CTL) which consists of the operational GEFS but its integration is extended from 16 to 35 days. The three configurations are: 1) SPs, which uses a Stochastically Perturbed Physics Tendencies (SPPT), Stochastic Perturbed Humidity (SHUM) and Stochastic Kinetic Energy Backscatter (SKEB); 2) SPs+SST_bc, which uses a combination of SPs and a bias-corrected forecast SST from the NCEP Climate Forecast System Version 2 (CFSv2); and 3) SPs+SST_bc+SA_CV, which combines SPs, a bias-corrected forecast SST and a scale aware convection scheme. When comparing to the CTL experiment, SPs shows substantial improvement. The MJO skill has improved by about 4 lead days during the 2-year period. Improvement is also seen over the extra-tropics due to the updated stochastic physics, where there is a 3.1% and a 4.2% improvement during weeks 3 and 4 over the northern hemisphere and southern hemisphere, respectively. Improvement is also seen when the bias-corrected CFSv2 SST is combined with SPs. Additionally, forecast performance enhances when the scale aware convection scheme (SPs+SST_bc+SA_CV) is added, especially over the tropics. Among the three experiments, the SPs+SST_bc+SA_CV is the best configuration in MJO forecast skill.

Projected SST trends across the Caribbean Sea based on PRECIS downscaling of ECHAM4, under the SRES A2 and B2 scenarios

NASA Astrophysics Data System (ADS)

Nurse, Leonard A.; Charlery, John L.

2016-01-01

The Caribbean Sea and adjacent land areas are highly sensitive to the projected impacts of global climate change. The countries bordering the Caribbean Sea depend heavily on coastal and marine assets as a major source of livelihood support. Rising sea surface temperatures (SSTs) are known to be associated with coral bleaching, ocean acidification, and other phenomena that threaten livelihoods in the region. The paucity of SST systematic observations in both the Caribbean Sea and adjoining Western Atlantic waters is a limiting factor in the projection of future climate change impacts on the region's marine resources. Remote sensing of SST by satellites began only within the last three decades and although the data collected so far might be insufficient to provide conclusive definitions of long-term SST variations in the Caribbean waters, these data along with the output from climate model simulations provide a useful basis for gaining further insights into plausible SST futures under IPCC SRES scenarios. In this paper, we examine the recent SST records from the NESDIS AVHRR satellite data and NOAA Optimum Interpolation (OI) sea surface temperature V2 and provide a comparative analysis of projected SST changes for the Caribbean Sea up to the end of the twenty-first century, under the SRES A2 and B2 scenarios' simulations of the sea surface skin temperatures (SSsT) using the Hadley Centre's regional model, PRECIS. The implications of these projected SST changes for bleaching of coral reefs, one of the region's most valuable marine resource, and for rainfall are also discussed.

Monitoring and trend mapping of sea surface temperature (SST) from MODIS data: a case study of Mumbai coast.

PubMed

Azmi, Samee; Agarwadkar, Yogesh; Bhattacharya, Mohor; Apte, Mugdha; Inamdar, Arun B

2015-04-01

Sea surface temperature (SST) is one of the most important parameters in monitoring ecosystem health in the marine and coastal environment. Coastal ecosystem is largely dependent on ambient temperature and temperature fronts for marine/coastal habitat and its sustainability. Hence, thermal pollution is seen as a severe threat for ecological health of coastal waters across the world. Mumbai is one of the largest metropolises of the world and faces severe domestic and industrial effluent disposal problem, of which thermal pollution is a major issue with policy-makers and environmental stakeholders. This study attempts to understand the long-term SST variation in the coastal waters off Mumbai, on the western coast of India, and to identify thermal pollution zones. Analysis of SST trends in the near-coastal waters for the pre- and post-monsoon seasons from the year 2004 to the year 2010 has been carried out using Moderate Resolution Imaging Spectro-radiometer (MODIS) Thermal Infra-red (TIR) bands. SST is calculated with the help of bands 31 and 32 using split window method. Several statistical operations were then applied to find the seasonal averages in SST and the standard deviation of SST in the study area. Maximum variation in SST was found within a perpendicular distance of 5 km from the shoreline during the study period. Also, a warm water mass was found to form consistently off coast during the winter months. Several anthropogenic sources of thermal pollution could be identified which were found to impact various locations along the coast.

Effects of southeastern Pacific sea surface temperature on the double-ITCZ bias in NCAR CESM1

NASA Astrophysics Data System (ADS)

Song, F.; Zhang, G. J.

2016-12-01

The double-intertropical convergence zone (ITCZ) is a long-standing bias in the coupled general circulation models (CGCMs). The warm biases in southeastern Pacific (SEP) sea surface temperature (SST) are also evident in many CGCMs. In this study, the role of SEP SST in the double-ITCZ is investigated by prescribing the observed SEP SST in the Community Earth System Model version 1 (CESM1). Both the double-ITCZ and dry equator problems are significantly improved with SEP SST prescribed. The colder SST over the SEP increases the southeasterly winds extending outside the prescribed SST region, cooling the ocean there via increased evaporation. The enhanced descending motion over the SEP strengthens the Walker circulation, so the low-level wind convergence in the tropical western Pacific is increased. The reduced wind speed leads to warmer SST and stronger convection there. The stronger convection in turn leads to more cloud and reduces the incoming solar radiation, cooling the SST. These competing effects between radiative heat flux and latent heat flux make the atmospheric heat flux secondary to the ocean dynamics in the western Pacific warming. The increased easterly winds over the equatorial Pacific enhance upwelling and shoal the thermocline over the eastern Pacific. This Bjerknes feedback plays an important role in the improvement of dry equator. The changes of surface wind and wind curl also lead to weaker South Equatorial Countercurrent and stronger South Equatorial Current, preventing the warm water from expanding eastward, thereby improving both the double-ITCZ and dry equator.

Pasireotide and octreotide antiproliferative effects and sst2 trafficking in human pancreatic neuroendocrine tumor cultures.

PubMed

Mohamed, Amira; Blanchard, Marie-Pierre; Albertelli, Manuela; Barbieri, Federica; Brue, Thierry; Niccoli, Patricia; Delpero, Jean-Robert; Monges, Genevieve; Garcia, Stephane; Ferone, Diego; Florio, Tullio; Enjalbert, Alain; Moutardier, Vincent; Schonbrunn, Agnes; Gerard, Corinne; Barlier, Anne; Saveanu, Alexandru

2014-10-01

Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) raise difficult therapeutic problems despite the emergence of targeted therapies. Somatostatin analogs (SSA) remain pivotal therapeutic drugs. However, the tachyphylaxis and the limited antitumoral effects observed with the classical somatostatin 2 (sst2) agonists (octreotide and lanreotide) led to the development of new SSA, such as the pan sst receptor agonist pasireotide. Our aim was to compare the effects of pasireotide and octreotide on cell survival, chromogranin A (CgA) secretion, and sst2 phosphorylation/trafficking in pancreatic NET (pNET) primary cells from 15 tumors. We established and characterized the primary cultures of human pancreatic tumors (pNETs) as powerful preclinical models for understanding the biological effects of SSA. At clinically relevant concentrations (1-10 nM), pasireotide was at least as efficient as octreotide in inhibiting CgA secretion and cell viability through caspase-dependent apoptosis during short treatments, irrespective of the expression levels of the different sst receptors or the WHO grade of the parental tumor. Interestingly, unlike octreotide, which induces a rapid and persistent partial internalization of sst2 associated with its phosphorylation on Ser341/343, pasireotide did not phosphorylate sst2 and induced a rapid and transient internalization of the receptor followed by a persistent recycling at the cell surface. These results provide the first evidence, to our knowledge, of striking differences in the dynamics of sst2 trafficking in pNET cells treated with the two SSAs, but with similar efficiency in the control of CgA secretion and cell viability. © 2014 Society for Endocrinology.

Serum soluble ST2 as diagnostic marker of systemic inflammatory reactive syndrome of bacterial etiology in children.

PubMed

Calò Carducci, Francesca Ippolita; Aufiero, Lelia Rotondi; Folgori, Laura; Vittucci, Anna Chiara; Amodio, Donato; De Luca, Maia; Li Pira, Giuseppina; Bergamini, Alberto; Pontrelli, Giuseppe; Finocchi, Andrea; D'Argenio, Patrizia

2014-02-01

Accurate and timely diagnosis of community-acquired bacterial versus viral infections in children with systemic inflammatory response syndrome (SIRS) remains challenging both for clinician and laboratory. In the quest of new biochemical markers to distinguish bacterial from viral infection, we have explored the possible role of the soluble secreted form of ST2 (sST2). This explorative prospective cohort study included children with SIRS who were suspected of having community-acquired infections. Plasma samples for sST2 measurement were obtained from 64 hospitalized children, 41 of whom had SIRS of bacterial etiology and 23 SIRS of viral etiology, and from 20 healthy, age- and sex-matched control children. sST2 measurement was carried out by enzyme-linked immunosorbent assay in parallel with standard measurements of procalcitonin (PCT) and C reactive protein (CRP). Our findings demonstrate that children with SIRS associated with bacterial infection present significantly increased levels of sST2, when compared with patients with SIRS of viral etiology and healthy children. More important, receiver operating characteristic curve analysis indicated that sST2 has a significant diagnostic performance with respect to early identification of SIRS of bacterial etiology, which was similar to that of PCT and greater than that of CRP. Finally, the combination of sST2 plus PCT and/or CRP, and PCT plus CRP increased their sensitivity and negative predictive value compared with sST2, PCT and CRP alone. In conclusion, sST2 level may prove useful in predicting bacterial etiology in children with SIRS.

Stratospheric role in interdecadal changes of El Niño impacts over Europe

NASA Astrophysics Data System (ADS)

Ayarzagüena, B.; López-Parages, J.; Iza, M.; Calvo, N.; Rodríguez-Fonseca, B.

2018-04-01

The European precipitation response to El Niño (EN) has been found to present interdecadal changes, with alternated periods of important or negligible EN impact in late winter. These periods are associated with opposite phases of multi-decadal sea surface temperature (SST) variability, which modifies the tropospheric background and EN teleconnections. In addition, other studies have shown how SST anomalies in the equatorial Pacific, and in particular, the location of the largest anomalous SST, modulate the stratospheric response to EN. Nevertheless, the role of the stratosphere on the stationarity of EN response has not been investigated in detail so far. Using reanalysis data, we present a comprehensive study of EN teleconnections to Europe including the role of the ocean background and the stratosphere in the stationarity of the signal. The results reveal multidecadal variability in the location of EN-related SST anomalies that determines different teleconnections. In periods with relevant precipitation signal over Europe, the EN SST pattern resembles Eastern Pacific EN and the stratospheric pathway plays a key role in transmitting the signal to Europe in February, together with two tropospheric wavetrains that transmit the signal in February and April. Conversely, the stratospheric pathway is not detected in periods with a weak EN impact on European precipitation, corresponding to EN-related SST anomalies primarily located over the central Pacific. SST mean state and its associated atmospheric background control the location of EN-related SST anomalies in different periods and modulate the establishment of the aforementioned stratospheric pathway of EN teleconnection to Europe too.

Analysis of Transportation Options for Commercial Spent Fuel in the U.S.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kalinina, Elena; Busch, Ingrid Karin

The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S.more » Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage and associated transportation of spent nuclear fuel (SNF) highand associated transportation of spent nuclear fuel (SNF) and 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Early Student Support for SST Control by Subsurface Mixing during Indian Ocean Monsoons

DTIC Science & Technology

2015-09-30

Lee and Rainville), and NRL (Wijesekera). OBJECTIVES The objectives of this project are to: 1. use satellite-measured SSS , SST, and SSH to...forcing, and 5. synthesize the above information and products to examine links and feedbacks between the SST and SSS of the SLD and local precipitation

Estimation of sea surface temperature from remote sensing in the 11to 13-micron window region

NASA Technical Reports Server (NTRS)

Prabhakara, C.; Kunde, V. G.; Dalu, G.

1974-01-01

The Nimbus 3 and 4 Iris spectral data in the 11- to 13-micron water vapor window region are analyzed to determine the sea surface temperature (SST). The high spectral resolution data of Iris are averaged over approximately 1-micron-wide intervals to simulate channels of a radiometer to measure the SST. In the present exploratory study, three such channels in the 775- to 960-per cm (12.9-10.5 micron) region are utilized to measure the SST over cloud-free oceans. However, two of these channels are sufficient in routine SST determination. The differential absorption properties of water vapor in the two channels make it possible to determine the water vapor absorption correction without detailed knowledge of the vertical profiles of temperature and water vapor. The feasibility of determining the SST is demonstrated globally with Nimbus 3 data, where cloud-free areas can be selected with the help of albedo data from the medium-resolution infrared radiometer experiment on board the same satellite. The SST derived from this technique agrees with the measurements made by ships to about 1 C.-

On the Regulation of the Pacific Warm Pool Temperature

NASA Technical Reports Server (NTRS)

Chou, Ming-Dah; Chou, Sue-Hsien; Chan, Pui-King; Lau, William K. M. (Technical Monitor)

2002-01-01

In the tropical western Pacific, regions of the highest sea surface temperature (SST) and the largest cloud cover are found to have the largest surface heating, primarily due to the weak evaporative cooling associated with weak winds. This situation is in variance with the suggestions that the temperature in the Pacific warm pool is regulated either by the reduced solar heating due to an enhanced cloudiness or by the enhanced evaporative cooling due to an elevated SST. It is clear that an enhanced surface heating in an enhanced convection region is not sustainable and must be interrupted by variations in large-scale atmospheric circulation. As the deep convective regions shift away from regions of high SST due primarily to seasonal variation and secondarily to interannual variation of the large-scale atmospheric and oceanic circulation, both trade wind and evaporative cooling in the high SST region increase, leading to a reduction in SST. We conclude that the evaporative cooling associated with the seasonal and interannual variations of trade winds in the primary factor that prevent the warm pool SST from increasing to a value much higher than what is observed.

Comparison of two Centennial-scale Sea Surface Temperature Datasets in the Regional Climate Change Studies of the China Seas

NASA Astrophysics Data System (ADS)

Qingyuan, Wang; Yanan, Wang; Yiwei, Liu

2017-08-01

Two widely used sea surface temperature (SST) datasets are compared in this article. We examine characteristics in the climate variability of SST in the China Seas.Two series yielded almost the same warming trend for 1890-2013 (0.7-0.8°C/100 years). However, HadISST1 series shows much stronger warming trends during 1961-2013 and 1981-2013 than that of COBE SST2 series. The disagreement between data sets was marked after 1981. For the hiatus period 1998-2013, the cooling trends of HadISST1 series is much lower than that of COBE SST2. These differences between the two datasets are possibly caused by the different observations which are incorporated to fill with data-sparse regions since 1982. Those findings illustrate that there are some uncertainties in the estimate of SST warming patterns in certain regions. The results also indicate that the temporal and spatial deficiency of observed data is still the biggest handicap for analyzing multi-scale SST characteristics in regional area.

Some analyses of the chemistry and diffusion of SST exhaust materials during phase 3 of the wake period. [in lower stratosphere

NASA Technical Reports Server (NTRS)

Hilst, G. R.; Donaldson, C. D.; Contiliano, R. M.

1973-01-01

In the generally stably stratified lower stratosphere, SST exhaust plumes could spend a significant length of time in a relatively undispersed state. This effort has utilized invariant modeling techniques to simulate the separate and combined effects of atmospheric turbulence, turbulent diffusion, and chemical reactions of SST exhaust materials in the lower stratosphere. The primary results to date are: (1) The combination of relatively slow diffusive mixing and rapid chemical reactions during the Phase III wake period minimizes the effect of SST exhausts on O3 depletion by the so-called NOx catalytic cycle. While the SST-produced NO is substantially above background concentrations, it appears diffusive mixing of NO and O3 is simply too slow to produce the O3 depletions originally proposed. (2) The time required to dilute the SST exhaust plume may be a significant fraction of the total time these materials are resident in the lower stratosphere. If this is the case, then prior estimates of the environmental impact of these materials must be revised significantly downward.

The single mirror small size telescope (SST-1M) of the Cherenkov Telescope Array

NASA Astrophysics Data System (ADS)

Aguilar, J. A.; Bilnik, W.; Borkowski, J.; Cadoux, F.; Christov, A.; della Volpe, D.; Favre, Y.; Heller, M.; Kasperek, J.; Lyard, E.; Marszałek, A.; Moderski, R.; Montaruli, T.; Porcelli, A.; Prandini, E.; Rajda, P.; Rameez, M.; Schioppa, E., Jr.; Troyano Pujadas, I.; Zietara, K.; Blocki, J.; Bogacz, L.; Bulik, T.; Frankowski, A.; Grudzinska, M.; Idźkowski, B.; Jamrozy, M.; Janiak, M.; Lalik, K.; Mach, E.; Mandat, D.; Michałowski, J.; Neronov, A.; Niemiec, J.; Ostrowski, M.; Paśko, P.; Pech, M.; Schovanek, P.; Seweryn, K.; Skowron, K.; Sliusar, V.; Stawarz, L.; Stodulska, M.; Stodulski, M.; Toscano, S.; Walter, R.; WiÈ©cek, M.; Zagdański, A.

2016-07-01

The Small Size Telescope with Single Mirror (SST-1M) is one of the proposed types of Small Size Telescopes (SST) for the Cherenkov Telescope Array (CTA). The CTA south array will be composed of about 100 telescopes, out of which about 70 are of SST class, which are optimized for the detection of gamma rays in the energy range from 5 TeV to 300 TeV. The SST-1M implements a Davies-Cotton optics with a 4 m dish diameter with a field of view of 9°. The Cherenkov light produced in atmospheric showers is focused onto a 88 cm wide hexagonal photo-detection plane, composed of 1296 custom designed large area hexagonal silicon photomultipliers (SiPM) and a fully digital readout and trigger system. The SST-1M camera has been designed to provide high performance in a robust as well as compact and lightweight design. In this contribution, we review the different steps that led to the realization of the telescope prototype and its innovative camera.

Operational use of high-resolution sst in a coupled sea ice-ocean model

NASA Astrophysics Data System (ADS)

Albretsen, A.

2003-04-01

A high-latitude, near real time, sea surface temperature (SST) product with 10 km resolution is developed at the Norwegian Meteorological Institute (met.no) through the EUMETSAT project OSI-SAF (Ocean and Sea Ice Satellite Application Facility). The product covers the Atlantic Ocean from 50N to 90N and is produced twice daily. A digitized SST and sea ice map is produced manually once a week at the Ice Mapping Service at met.no using all available information from the previous week. This map is the basis for a daily SST analysis, in which the most recent OSI-SAF SST products are successively overlaid. The resulting SST analysis field is then used in a simple data assimilation scheme in a coupled ice-ocean model to perform daily 10 days forecasts of ocean and sea ice variables. Also, the associated OSI-SAF sea ice concentration product, built from different polar orbiting satellites, is assimilated into the sea ice model. Preliminary estimates of impact on forecast skill and error statistics will be presented.

Contribution of tropical cyclones to abnormal sea surface temperature warming in the Yellow Sea in December 2004

NASA Astrophysics Data System (ADS)

Kim, Taekyun; Choo, Sung-Ho; Moon, Jae-Hong; Chang, Pil-Hun

2017-12-01

Unusual sea surface temperature (SST) warming occurred over the Yellow Sea (YS) in December 2004. To identify the causes of the abnormal SST warming, we conducted an analysis on atmospheric circulation anomalies induced by tropical cyclones (TCs) and their impacts on upper ocean characteristics using multiple datasets. With the analysis of various datasets, we explored a new aspect of the relationship between TC activity and SST. The results show that there is a significant link between TC activity over the Northwest Pacific (NWP) and SST in the YS. The integrated effect of consecutive TCs activity induces a large-scale atmospheric cyclonic circulation anomaly over the NWP and consequently anomalous easterly winds over the YS and East China Sea. The mechanism of the unusually warm SST in the YS can be explained by considering TCs acting as an important source of Ekman heat transport that results in substantial intrusion of relatively warm surface water into the YS interior. Furthermore, TC-related circulation anomalies contribute to the retention of the resulting warm SST anomalies in the entire YS.

The Teleconnection Pattern between Hawaii Rainfall and Large-Scale Circulation in Present-Day Conditions and during the Holocene

NASA Astrophysics Data System (ADS)

Li, S.; Elison Timm, O.

2016-12-01

Kona lows (KLs) are a type of seasonal cut-off cyclones in the North Pacific around the Hawaiian Islands during the cold season month (Oct.-Apr.). KL are important for the annual rainfall budget of the Hawaiian Islands. In this study, the relationship between KLs and North Pacific climate variability was analyzed in order to understand the interannual variations in the number of KLs. The main objectives were (1) to identify mechanisms that control the activity of KL during the recent decades, and (2) to test the stability of the statistical relationships with respect to decadal-scale variability and/or climate shifts. Our study is based on the new data set of KL counts from 1979-2014 (Kaiser, 2014, Univ. Hawaii). For the analysis of large-scale climate pattern, ERA-interim 6-hourly data from 1979-2014 were used including sea level pressure, geopotential heights of the 500hPa level, potential vorticity and zonal wind at 250hPa. We derived cold season averages for the mean and 8-16 day synoptic variability. Standard climate indices for tropical-extratropical climate variability included NINO3.4 and PDO index, and NPO index. The results from the linear correlation analysis show that local 8-16day PV250 variability north of Hawaii can represent Kona Low activity between 1979-2014. KL activity and PV250 variability had both a negative correlation with NINO3.4 index. However, the correlation with NINO3.4 index has diminished after 1995. This shift in correlation coincides with transition of the PDO index from a positive value to negative value during 1990's. Our results suggest that a negative PDO can reduce the ENSO influence on Kona Low activity by modulating the upper zonal jet response. We investigated further the relationship between NPO and Kona Low activity. A strong correlation with the NPO index was found. Two factors that control the time-dependent impacts of ENSO on the KL activity. After the mid-1990s the central tropical Pacific SST were more closely tied to the extratropical NPO mode. In order to test if the results are applicable in the context of paleoclimate applications, where the stability of tropical-extratropical teleconnection mechanisms is crucial for the interpretation of paleoclimate proxy data, we tested the robustness of our results in the TraCE-21ka simulation during the Holocene.

Warming off southwestern Japan linked to distributional shifts of subtidal canopy-forming seaweeds.

PubMed

Tanaka, Kouki; Taino, Seiya; Haraguchi, Hiroko; Prendergast, Gabrielle; Hiraoka, Masanori

2012-11-01

To assess distributional shifts of species in response to recent warming, historical distribution records are the most requisite information. The surface seawater temperature (SST) of Kochi Prefecture, southwestern Japan on the western North Pacific, has significantly risen, being warmed by the Kuroshio Current. Past distributional records of subtidal canopy-forming seaweeds (Laminariales and Fucales) exist at about 10-year intervals from the 1970s, along with detailed SST datasets at several sites along Kochi's >700 km coastline. In order to provide a clear picture of distributional shifts of coastal marine organisms in response to warming SST, we observed the present distribution of seaweeds and analyzed the SST datasets to estimate spatiotemporal SST trends in this coastal region. We present a large increase of 0.3°C/decade in the annual mean SST of this area over the past 40 years. Furthermore, a comparison of the previous and present distributions clearly showed the contraction of temperate species' distributional ranges and expansion of tropical species' distributional ranges in the seaweeds. Although the main temperate kelp Ecklonia (Laminariales) had expanded their distribution during periods of cooler SST, they subsequently declined as the SST warmed. Notably, the warmest SST of the 1997-98 El Niño Southern Oscillation event was the most likely cause of a widespread destruction of the kelp populations; no recovery was found even in the present survey at the formerly habitable sites where warm SSTs have been maintained. Temperate Sargassum spp. (Fucales) that dominated widely in the 1970s also declined in accordance with recent warming SSTs. In contrast, the tropical species, S. ilicifolium, has gradually expanded its distribution to become the most conspicuously dominant among the present observations. Thermal gradients, mainly driven by the warming Kuroshio Current, are presented as an explanation for the successive changes in both temperate and tropical species' distributions.

A reconstruction of sea surface temperature variability in the southeastern Gulf of Mexico from 1734 to 2008 C.E. using cross-dated Sr/Ca records from the coral Siderastrea siderea

NASA Astrophysics Data System (ADS)

DeLong, Kristine L.; Flannery, Jennifer A.; Poore, Richard Z.; Quinn, Terrence M.; Maupin, Christopher R.; Lin, Ke; Shen, Chuan-Chou

2014-05-01

This study uses skeletal variations in coral Sr/Ca from three Siderastrea siderea coral colonies within the Dry Tortugas National Park in the southeastern Gulf of Mexico (24°42'N, 82°48'W) to reconstruct monthly sea surface temperature (SST) variations from 1734 to 2008 Common Era (C.E.). Calibration and verification of the replicated coral Sr/Ca-SST reconstruction with local, regional, and historical temperature records reveals that this proxy-temperature relationship is stable back to 1879 C.E. The coral SST reconstruction contains robust interannual ( 2.0°C) and multidecadal variability ( 1.5°C) for the past 274 years, the latter of which does not covary with the Atlantic Multidecadal Oscillation. Winter SST extremes are more variable than summer SST extremes (±2.2°C versus ±1.6°C, 2σ) suggesting that Loop Current transport in the winter dominates variability on interannual and longer time scales. Summer SST maxima are increasing (+1.0°C for 274 years, σMC = ±0.5°C, 2σ), whereas winter SST minima contain no significant trend. Colder decades ( 1.5°C) during the Little Ice Age (LIA) do not coincide with decades of sunspot minima. The coral SST reconstruction contains similar variability to temperature reconstructions from the northern Gulf of Mexico (planktic foraminifer Mg/Ca) and the Caribbean Sea (coral Sr/Ca) suggesting areal reductions in the Western Hemisphere Warm Pool during the LIA. Mean summer coral SST extremes post-1985 C.E. (29.9°C) exceeds the long-term summer average (29.2°C for 1734-2008 C.E.), yet the warming trend after 1985 C.E. (0.04°C for 24 years, σMC = ±0.5, 2σ) is not significant, whereas Caribbean coral Sr/Ca studies contain a warming trend for this interval.

Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain.

PubMed

Billova, S; Galanopoulou, A S; Seidah, N G; Qiu, X; Kumar, U

2007-06-29

The processing of many peptides for their maturation in target tissue depends upon the presence of sorting receptor. Several previous studies have predicted that carboxypeptidase-E (CPE), prohormone convertase 1 (PC1) and prohormone convertase 2 (PC2) may function as sorting elements for somatostatin (SST) for its maturation and processing to appropriate targets. However, nothing is currently known about whether brain, neuronal culture or even endocrine cells express SST, CPE, PC1 and PC2 and exhibit colocalization. Accordingly, in the present study using peroxidase immunohistochemistry, double-labeled indirect immunofluorescence immunohistochemistry and Western blot analysis, we mapped the distributional pattern of SST, CPE, PC1 and PC2 in different rat brain regions. Additionally, we also determined the colocalization of SST with CPE, PC1 and PC2 as well as colocalization of CPE with PC1 and PC2. The localization of SST, CPE, PC1 and PC2 reveals a distinct and region specific distribution pattern in the rat brain. Using an indirect double-label immunofluorescence method we observed selective neuron specific colocalization in a region specific manner in cortex, striatum and hippocampus. These studies provide the first evidence for colocalization between SST, CPE, PC1 and PC2 as well as CPE with PC1 and PC2. SST in cerebral cortex colocalized in pyramidal and non-pyramidal neurons with CPE, PC1 and PC2. Most importantly, in striatum and hippocampus colocalization was mostly observed selectively and preferentially in interneurons. CPE is also colocalized with PC1 and PC2 in a region specific manner. The data presented here provide a new insight into the distribution and colocalization of SST, CPE, PC1 and PC2 in rat brain. Taken together, our data anticipate the possibility that CPE, PC1 and PC2 might be potential target for the maturation of SST.

The super greenhouse effect in a warming world: the role of dynamics and thermodynamics

NASA Astrophysics Data System (ADS)

Kashinath, Karthik; O'Brien, Travis; Collins, William

2016-04-01

Over warm tropical oceans the increase in greenhouse trapping with increasing SST can be faster than that of the surface emission, resulting in a decrease in clear sky outgoing longwave radiation at the top of the atmosphere (OLR) when SST increases, also known as the super greenhouse effect (SGE). If the SGE is directly linked to SST changes, there are profound implications for positive climate feedbacks in the tropics. We show that CMIP5 models perform well in simulating the observed clear-sky greenhouse effect in the present day. Using global warming experiments we show that the onset and shutdown SST of the SGE, as well as the magnitude of the SGE, increase as the convective threshold SST increases. To account for an increasing convective threshold SST we use an invariant coordinate for convection proposed in a recent study [Williams et al., GRL (2009)]. However, even after accounting for the increase in tropical SST (by normalizing the SGE by surface emission) and accounting for the increase in the threshold temperature for convection (by using the invariant coordinate) we find that the models predict a distinct increase in the clear-sky greenhouse effect in a warmed world. This suggests that thermodynamics (i.e. SST) plays a crucial role in regulating the increasing clear sky greenhouse effect in a warming world. We use theoretical arguments to estimate this increase in SGE and derive its dependence on SST. Finally, as shown in previous studies, we confirm that the increase in the clear-sky greenhouse effect is primarily due to upper tropospheric moistening. Although the absolute increase in upper tropospheric water vapor is small compared to that of the lower troposphere, since the absorptivity scales with fractional changes in water vapor, the contribution of the upper troposphere is more significant, as shown by Chung et al., PNAS (2014).

ST2 and IL-33 in Pregnancy and Pre-Eclampsia

PubMed Central

Snider, James V.; Tannetta, Dionne S.; Child, Tim; Redman, Christopher W. G.; Sargent, Ian L.

2011-01-01

Normal pregnancy is associated with a mild systemic inflammatory response and an immune bias towards type 2 cytokine production, whereas pre-eclampsia is characterized by a more intense inflammatory response, associated with endothelial dysfunction and a type 1 cytokine dominance. Interleukin (IL)-33 is a newly described member of the IL-1 family, which binds its receptor ST2L to induce type 2 cytokines. A soluble variant of ST2 (sST2) acts as a decoy receptor to regulate the activity of IL-33. In this study circulating IL-33 and sST2 were measured in each trimester of normal pregnancy and in women with pre-eclampsia. While IL-33 did not change throughout normal pregnancy, or between non-pregnant, normal pregnant or pre-eclamptic women, sST2 was significantly altered. sST2 was increased in the third trimester of normal pregnancy (p<0.001) and was further increased in pre-eclampsia (p<0.001). This increase was seen prior to the onset of disease (p<0.01). Pre-eclampsia is a disease caused by placental derived factors, and we show that IL-33 and ST2 can be detected in lysates from both normal and pre-eclampsia placentas. ST2, but not IL-33, was identified on the syncytiotrophoblast layer, whereas IL-33 was expressed on perivascular tissue. In an in vitro placental perfusion model, sST2 was secreted by the placenta into the ‘maternal’ eluate, and placental explants treated with pro-inflammatory cytokines or subjected to hypoxia/reperfusion injury release more sST2, suggesting the origin of at least some of the increased amounts of circulating sST2 in pre-eclamptic women is the placenta. These results suggest that sST2 may play a significant role in pregnancies complicated by pre-eclampsia and increased sST2 could contribute to the type 1 bias seen in this disorder. PMID:21949719

A global monthly sea surface temperature climatology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shea, D.J.; Trenberth, K.E.; Reynolds, R.W.

1992-09-01

The paper presents a new global 2 deg x 2 deg monthly sea surface temperature (SST) climatology, referred here to as the Shea-Trenberth-Reynolds (STR) climatology, which was derived by modifying a 1950-1979-based SST climatology from the Climate Analysis Center (CAC), by using data from the Comprehensive Ocean-Atmosphere Data Set to improve the SST estimates in the regions of the Kuroshio and the Gulf Stream. A comparison of the STR climatology with the Alexander and Mobley SST climatology showed that the STR climatology is warmer in the Northern Hemisphere, and colder poleward of 45 deg S. 22 refs.

Differential effect of blood collection tubes on total free fatty acids (FFA) and total triiodothyronine (TT3) concentration: a model for studying interference from tube constituents.

PubMed

Bowen, Raffick A R; Vu, Chi; Remaley, Alan T; Hortin, Glen L; Csako, Gyorgy

2007-03-01

Besides total triiodothyronine (TT3), total free fatty acids (FFA) concentrations were higher with serum separator tube (SST) than Vacuette tubes. The effects of surfactant, rubber stopper, and separator gel from various tubes were investigated on FFA, beta-hydroxybutyrate (beta-HB), and TT3 with 8 different tube types in blood specimens of apparently healthy volunteers. Compared to Vacuette tubes, serum FFA and TT3 concentrations were significantly higher in SST than glass tubes. Reformulated SST eliminated the increase in TT3 but not FFA. No significant difference was observed for beta-HB concentration among tube types. Surfactant and rubber stoppers from the different tube types significantly increased TT3 but not FFA and beta-HB concentrations. Agitation of whole blood but not serum or plasma specimens with separator gel from SST, reformulated SST and plasma preparation tube (PPT) tubes compared to Vacuette tubes gave higher FFA but not beta-HB levels. Unidentified component(s) from the separator gel in SST, reformulated SST and PPT tubes cause falsely high FFA concentration. In contrast to TT3, falsely high FFA results require exposure of whole blood and not serum to tube constituent(s). The approach employed here may serve as a model for assessing interference(s) from tube constituent(s).

The Influence of Ocean on Typhoon Nuri (2008)

NASA Astrophysics Data System (ADS)

Sun, J.; Oey, L. Y.; Xu, F.; Lin, Y.; Huang, S. M.; Chang, R.

2014-12-01

The influence of ocean on typhoon Nuri (2008) is investigated in this study using the WRF numerical model. Typhoon Nuri formed over the warm pool of the western North Pacific. The storm traversed west-northwestward and became a Category 3 typhoon over the Kuroshio east of the Luzon Strait and weakened as it moved across South China Sea. Three types of SST: NCEP RTG_SST (Real-time，global，sea surface temperature) GHRsst (Group for High Resolution Sea Surface Temperature) and SST from the ATOP North Pacific ocean model [Oey et al 2014, JPO] are used in WRF to test the effect of ocean on the intensity of typhoon Nuri. The typhoon intensity and track are also compared with simulations using different microphysics schemes but with fixed SST. The results show that thermodynamic control through ocean response is the dominant factor which determines Nuri's intensity. The simulated intensity agrees well with the observed intensity when ATOP SST is used, while using NCEP SST and GHRsst yield errors both in intensity and timing of maximum intensity. Over the Kuroshio, the thicker depth of 26 ℃ from ATOP provides stronger heating for the correct timing of intensification of Nuri. In South China Sea, the storm weakened because of cooled SST through ocean mixing by inertial resonance. A new way of explaining typhoon intensification though PV is proposed.

Assimilation for skin SST in the NASA GEOS atmospheric data assimilation system

PubMed Central

Akella, Santha; Todling, Ricardo; Suarez, Max

2018-01-01

The present article describes the sea surface temperature (SST) developments implemented in the Goddard Earth Observing System, Version 5 (GEOS-5) Atmospheric Data Assimilation System (ADAS). These are enhancements that contribute to the development of an atmosphere-ocean coupled data assimilation system using GEOS. In the current quasi-operational GEOS-ADAS, the SST is a boundary condition prescribed based on the OSTIA product, therefore SST and skin SST (Ts) are identical. This work modifies the GEOS-ADAS Ts by modeling and assimilating near sea surface sensitive satellite infrared (IR) observations. The atmosphere-ocean interface layer of the GEOS atmospheric general circulation model (AGCM) is updated to include near surface diurnal warming and cool-skin effects. The GEOS analysis system is also updated to directly assimilate SST-relevant Advanced Very High Resolution Radiometer (AVHRR) radiance observations. Data assimilation experiments designed to evaluate the Ts modification in GEOS-ADAS show improvements in the assimilation of radiance observations that extends beyond the thermal IR bands of AVHRR. In particular, many channels of hyperspectral sensors, such as those of the Atmospheric Infrared Sounder (AIRS), and Infrared Atmospheric Sounding Interferometer (IASI) are also better assimilated. We also obtained improved fit to withheld, in-situ buoy measurement of near-surface SST. Evaluation of forecast skill scores show marginal to neutral benefit from the modified Ts. PMID:29628531

Relative roles of differential SST warming, uniform SST warming and land surface warming in determining the Walker circulation changes under global warming

NASA Astrophysics Data System (ADS)

Zhang, Lei; Li, Tim

2017-02-01

Most of CMIP5 models projected a weakened Walker circulation in tropical Pacific, but what causes such change is still an open question. By conducting idealized numerical simulations separating the effects of the spatially uniform sea surface temperature (SST) warming, extra land surface warming and differential SST warming, we demonstrate that the weakening of the Walker circulation is attributed to the western North Pacific (WNP) monsoon and South America land effects. The effect of the uniform SST warming is through so-called "richest-get-richer" mechanism. In response to a uniform surface warming, the WNP monsoon is enhanced by competing moisture with other large-scale convective branches. The strengthened WNP monsoon further induces surface westerlies in the equatorial western-central Pacific, weakening the Walker circulation. The increase of the greenhouse gases leads to a larger land surface warming than ocean surface. As a result, a greater thermal contrast occurs between American Continent and equatorial Pacific. The so-induced zonal pressure gradient anomaly forces low-level westerly anomalies over the equatorial eastern Pacific and weakens the Walker circulation. The differential SST warming also plays a role in driving low-level westerly anomalies over tropical Pacific. But such an effect involves a positive air-sea feedback that amplifies the weakening of both east-west SST gradient and Pacific trade winds.

Changes in ENSO amplitude under climate warming and cooling

NASA Astrophysics Data System (ADS)

Wang, Yingying; Luo, Yiyong; Lu, Jian; Liu, Fukai

2018-05-01

The response of ENSO amplitude to climate warming and cooling is investigated using the Community Earth System Model (CESM), in which the warming and cooling scenarios are designed by adding heat fluxes of equal amplitude but opposite sign onto the ocean surface, respectively. Results show that the warming induces an increase of the ENSO amplitude but the cooling gives rise to a decrease of the ENSO amplitude, and these changes are robust in statistics. A mixed layer heat budget analysis finds that the increasing (decreasing) SST tendency under climate warming (cooling) is mainly due to an enhancement (weakening) of dynamical feedback processes over the equatorial Pacific, including zonal advective (ZA) feedback, meridional advective (MA) feedback, thermocline (TH) feedback, and Ekman (EK) feedback. As the climate warms, a wind anomaly of the same magnitude across the equatorial Pacific can induce a stronger zonal current change in the east (i.e., a stronger ZA feedback), which in turn produces a greater weakening of upwelling (i.e., a stronger EK feedback) and thus a larger thermocline change (i.e., a stronger TH feedback). In response to the climate warming, in addition, the MA feedback is also strengthened due to an enhancement of the meridional SST gradient around the equator resulting from a weakening of the subtropical cells (STCs). It should be noted that the weakened STCs itself has a negative contribution to the change of the MA feedback which, however, appears to be secondary. And vice versa for the cooling case. Bjerknes linear stability (BJ) index is also evaluated for the linear stability of ENSO, with remarkably larger (smaller) BJ index found for the warming (cooling) case.

Upper-tropospheric environment-tropical cyclone interactions over the western North Pacific: A statistical study

NASA Astrophysics Data System (ADS)

Qian, Yu-Kun; Liang, Chang-Xia; Yuan, Zhuojian; Peng, Shiqiu; Wu, Junjie; Wang, Sihua

2016-05-01

Based on 25-year (1987-2011) tropical cyclone (TC) best track data, a statistical study was carried out to investigate the basic features of upper-tropospheric TC-environment interactions over the western North Pacific. Interaction was defined as the absolute value of eddy momentum flux convergence (EFC) exceeding 10 m s-1 d-1. Based on this definition, it was found that 18% of all six-hourly TC samples experienced interaction. Extreme interaction cases showed that EFC can reach ~120 m s-1 d-1 during the extratropical-cyclone (EC) stage, an order of magnitude larger than reported in previous studies. Composite analysis showed that positive interactions are characterized by a double-jet flow pattern, rather than the traditional trough pattern, because it is the jets that bring in large EFC from the upper-level environment to the TC center. The role of the outflow jet is also enhanced by relatively low inertial stability, as compared to the inflow jet. Among several environmental factors, it was found that extremely large EFC is usually accompanied by high inertial stability, low SST and strong vertical wind shear (VWS). Thus, the positive effect of EFC is cancelled by their negative effects. Only those samples during the EC stage, whose intensities were less dependent on VWS and the underlying SST, could survive in extremely large EFC environments, or even re-intensify. For classical TCs (not in the EC stage), it was found that environments with a moderate EFC value generally below ~25 m s-1 d-1 are more favorable for a TC's intensification than those with extremely large EFC.

Development of a Support Application and a Textbook for Practicing Facial Expression Detection for Students with Visual Impairment

ERIC Educational Resources Information Center

Saito, Hirotaka; Ando, Akinobu; Itagaki, Shota; Kawada, Taku; Davis, Darold; Nagai, Nobuyuki

2017-01-01

Until now, when practicing facial expression recognition skills in nonverbal communication areas of SST, judgment of facial expression was not quantitative because the subjects of SST were judged by teachers. Therefore, we thought whether SST could be performed using facial expression detection devices that can quantitatively measure facial…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reidel, Stephen P.

This chapter summarizes the geology of the single-shell tank (SST) farms in the context of the region’s geologic history. This chapter is based on the information in the geology data package for the SST waste management areas and SST RFI Appendix E, which builds upon previous reports on the tank farm geology and Integrated Disposal Facility geology with information available after those reports were published.

Sustained Shared Thinking in an Early Childhood Setting: An Exploration of Practitioners' Perspectives

ERIC Educational Resources Information Center

Purdon, Anne

2016-01-01

Sustained shared thinking (SST) has been identified in the Teachers Standards (Early Years) (2013) as contributing to good progress and outcomes by children. In this paper, I define SST and discuss the outcomes of a study of practitioners' understandings of SST, its challenges and benefits. Writing frames, questionnaires and focus group interviews…

Interim prostacyclin therapy for an isolated disconnected pulmonary artery: a case report.

PubMed

Grech, Victor; Grixti, Cynthia

2010-06-02

Disconnected pulmonary arteries are unusual and may result in pulmonary hypertension with acute right heart failure. We report a case of a three-month-old Asian girl who presented with heart failure and severe pulmonary hypertension due to a disconnected right pulmonary artery. An epoprostenol (prostacyclin) infusion was instrumental in lowering pulmonary artery pressures and stabilizing the child prior to surgery. This is, to the best of our knowledge, the first report of successful prostacyclin usage in such a situation.

Investigating the sensitivity of hurricane intensity and trajectory to sea surface temperatures using the regional model WRF

NASA Astrophysics Data System (ADS)

Kilic, Cevahir; Raible, Christoph C.

2015-04-01

It is well known that the sea surface temperature (SST) has an influence on the development and intensification of tropical cyclones (TCs). This influence has become even more important during the past decades, as TCs show an intensification, which goes along with an increase in SSTs. The influence of sea surface temperature (SST) anomalies on the hurricane characteristics are investigated in a set of sensitivity experiments employing the Weather Research and Forecasting (WRF) model. The idealised experiments are performed for the case of Hurricane Katrina in 2005. (Kilic and Raible, 2013) The first set of sensitivity experiments with basin-wide changes of the SST magnitude shows that the intensity goes along with changes in the SST, i.e., an increase in SST leads to an intensification of Katrina. Additionally, the trajectory is shifted to the west (east), with increasing (decreasing) SSTs. The main reason is a strengthening of the background flow. To gain further insights in the dynamics, the potential vorticity (PV) and its tendency (PVT) are analysed. A positive PVT is located to the moving direction relative to the TC centre. Splitting the PVT in the horizontal advection, vertical advection, and diabatic heating terms, we find that mainly the horizontal advection term contributes to this PVT maximum, due to a steering by strong environmental flow. The impact of the diabatic heating is of minor importance and, hence, the TC motion is dominated by horizontal advection. The amount of the horizontal advection as well as the amount of the diabatic heating rise with increasing SST due to the enhanced Carnot cycle. The second set of experiments investigates the influence of Loop Current eddies idealised by localised SST anomalies. The intensity of Hurricane Katrina is enhanced with increasing SSTs close to the core of a TC. Negative nearby SST anomalies reduce the intensity. The trajectory only changes if positive SST anomalies are located west or north of the hurricane centre. In this case the hurricane is attracted by the SST anomaly which causes an additional moisture source and increased vertical winds. This study confirm the linear relation between SST and TC intensity. However, in case of localised SST anomalies, the relative location to the TC core determes the gradient of the linear relation. The gradient decreases with increasing distance between SST anomaly and initialisation point. The anomalies located west and north of the initialisation point have a stronger impact than the ones located south and east, as they lie in the moving direction of the TC. Further, in terms of magnitude and pattern, the horizontal advection term of PVT does not strongly differ from the reference simulation. However, the pattern of diabatic heating term differs: A maximum of diabatic heating is still located in moving direction, but additionally the diabatic heating is found in the spiral rain bands. Thus, the vortex is drifted to the SST anomaly due to the asymmetry in the TC circulation induced by the diabatic heating term of the PVT. References Kilic, C., and C. C. Raible, Investigating the sensitivity of hurricane intensity and trajectory to sea surface temperatures using the regional model WRF, METEOROLOGISCHE ZEITSCHRIFT, 22(6), 685-698, 2013.

Contrasting Indian Ocean SST Variability With and Without ENSO Influence: A Coupled Atmosphere-Ocean GCM Study

NASA Technical Reports Server (NTRS)

Yu, Jin-Yi; Lau, K. M.

2004-01-01

In this study, we perform experiments with a coupled atmosphere-ocean general circulation model (CGCM) to examine ENSO's influence on the interannual sea surface temperature (SST) variability of the tropical Indian Ocean. The control experiment includes both the Indian and Pacific Oceans in the ocean model component of the CGCM (the Indo-Pacific Run). The anomaly experiment excludes ENSOs influence by including only the Indian Ocean while prescribing monthly-varying climatological SSTs for the Pacific Ocean (the Indian-Ocean Run). In the Indo-Pacific Run, an oscillatory mode of the Indian Ocean SST variability is identified by a multi-channel singular spectral analysis (MSSA). The oscillatory mode comprises two patterns that can be identified with the Indian Ocean Zonal Mode (IOZM) and a basin-wide warming/cooling mode respectively. In the model, the IOZM peaks about 3-5 months after ENSO reaches its maximum intensity. The basin mode peaks 8 months after the IOZM. The timing and associated SST patterns suggests that the IOZM is related to ENSO, and the basin- wide warming/cooling develops as a result of the decay of the IOZM spreading SST anomalies from western Indian Ocean to the eastern Indian Ocean. In contrast, in the Indian-Ocean Run, no oscillatory modes can be identified by the MSSA, even though the Indian Ocean SST variability is characterized by east-west SST contrast patterns similar to the IOZM. In both control and anomaly runs, IOZM-like SST variability appears to be associated with forcings from fluctuations of the Indian monsoon. Our modeling results suggest that the oscillatory feature of the IOZM is primarily forced by ENSO.

Small change, big difference: Sea surface temperature distributions for tropical coral reef ecosystems, 1950-2011

NASA Astrophysics Data System (ADS)

Lough, J. M.

2012-09-01

Changes in tropical sea surface temperature (SST) are examined over the period 1950-2011 during which global average temperature warmed by 0.4°C. Average tropical SST is warming about 70% of the global average rate. Spatially, significant warming between the two time periods, 1950-1980 and 1981-2011, has occurred across 65% of the tropical oceans. Coral reef ecosystems occupy 10% of the tropical oceans, typically in regions of warmer (+1.8°C) and less variable SST (80% of months within 3.3°C range) compared to non-reef areas (80% of months within 7.0°C range). SST is a primary controlling factor of coral reef distribution and coral reef organisms have already shown their sensitivity to the relatively small amount of warming observed so far through, for example, more frequent coral bleaching events and outbreaks of coral disease. Experimental evidence is also emerging of possible thermal thresholds in the range 30°C-32°C for some physiological processes of coral reef organisms. Relatively small changes in SST have already resulted in quite large differences in SST distribution with a maximum ‘hot spot’ of change in the near-equatorial Indo-Pacific which encompasses both the Indo-Pacific warm pools and the center of coral reef biodiversity. Identification of this hot spot of SST change is not new but this study highlights its significance with respect to tropical coral reef ecosystems. Given the modest amount of warming to date, changes in SST distribution are of particular concern for coral reefs given additional local anthropogenic stresses on many reefs and ongoing ocean acidification likely to increasingly compromise coral reef processes.

A teleconnection study of interannual sea surface temperature fluctuations in the northern North Atlantic and precipitation and runoff over Western Siberia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peng, S.; Mysak, L.A.

The spatial distributions of northern North Atlantic sea surface temperature and the high-latitude Northern Hemisphere sea level pressure anomalies averaged over six consecutive warm SST winters (1951-1956) and six consecutive cold SST winters (1971-1976) are examined. Three SLP anomaly difference (i.e., warm - cold winters) centers, significant at the 5% level, are observed over the northern North Atlantic, Europe, and western Siberia. This anomaly pattern is consistent in principle with what was identified in a related analyses by Palmer and Sun, who used composite data from selected winter months. The SLP difference centers over the northern North Atlantic and westernmore » Siberia are in phase. The impact of the latter center upon the runoff from the underlying Ob and Yenisey rivers and especially the teleconnection between SST anomalies in the northern North Atlantic and runoff of those two rivers via the atmosphere are investigated. The temporal cross-correlation analyses of 50 years (1930-1979) of records of SST, precipitation, and runoff anomalies indicate that the winter SST anomalies in the northern North Atlantic are significantly correlated with the winter and following summer runoff fluctuations of the Ob and Yenisey rivers. Positive (negative) northern North Atlantic SST anomalies are related to less (more) precipitation, and hence, less (more) runoff, over western Siberia. Discussions of possible physical mechanisms and processes that lead to the above relationships are attempted. The analyses of spatial distributions of precipitation in the warm and cold SST winters suggest that precipitation fluctuations over Europe and western Siberia may be affected by shifts of cyclone tracks associated with the SST variations in the northern North Atlantic. 27 refs., 9 figs.« less

Causes of the large warm bias in the Angola-Benguela Frontal Zone in the Norwegian Earth System Model

NASA Astrophysics Data System (ADS)

Koseki, Shunya; Keenlyside, Noel; Demissie, Teferi; Toniazzo, Thomas; Counillon, Francois; Bethke, Ingo; Ilicak, Mehmet; Shen, Mao-Lin

2018-06-01

We have investigated the causes of the sea surface temperature (SST) bias in the Angola-Benguela Frontal Zone (ABFZ) of the southeastern Atlantic Ocean simulated by the Norwegian Earth System Model (NorESM). Similar to other coupled-models, NorESM has a warm SST bias in the ABFZ of up to 8 °C in the annual mean. Our analysis of NorESM reveals that a cyclonic surface wind bias over the ABFZ drives a locally excessively strong southward (0.05 m/s (relative to observation)) Angola Current displacing the ABFZ southward. A series of uncoupled stand-alone atmosphere and ocean model simulations are performed to investigate the cause of the coupled model bias. The stand-alone atmosphere model driven with observed SST exhibits a similar cyclonic surface circulation bias; while the stand-alone ocean model forced with the reanalysis data produces a warm SST in the ABFZ with a magnitude approximately half of that in the coupled NorESM simulation. An additional uncoupled sensitivity experiment shows that the atmospheric model's local negative surface wind curl generates anomalously strong Angola Current at the ocean surface. Consequently, this contributes to the warm SST bias in the ABFZ by 2 °C (compared to the reanalysis forced simulation). There is no evidence that local air-sea feedbacks among wind stress curl, SST, and sea level pressure (SLP) affect the ABFZ SST bias. Turbulent surface heat flux differences between coupled and uncoupled experiments explain the remaining 2 °C warm SST bias in NorESM. Ocean circulation, upwelling and turbulent heat flux errors all modulate the intensity and the seasonality of the ABFZ errors.

Sensitivity of Surface Temperature to Oceanic Forcing via q-Flux Green’s Function Experiments. Part I: Linear Response Function

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Fukai; Lu, Jian; Garuba, Oluwayemi

This paper explores the use of linear response function (LRF) to relate the mean sea surface temperature (SST) response to prescribed ocean heat convergence (q-flux) forcings. Two methods for constructing the LRF based on the fluctuation-dissipation theorem (FDT) and Green’s function (GRF) are examined. A 900-year preindustrial simulation from the Community Earth System Model with a slab ocean (CESM-SOM) is used to estimate the LRF using FDT. For GRF, 106 pairs of CESM-SOM simulations with warm and cold q-flux patches are performed. FDT is found to have skill in estimating the SST response to a q-flux forcing when the localmore » SST response is strong, but it fails in inverse estimation of the q-flux forcing for a given SST pattern. In contrast, GRF is shown to be reasonably accurate in estimating both SST response and q-flux forcing. Possible degradation in FDT may be attributed to insufficient data sampling, significant departures of the SST data from Gaussian, and the non-normality of the constructed operator. The accurately estimated GRF-based LRF is used to (i) generate a global surface temperature sensitivity map that shows the q-flux forcing in higher latitudes to be three to four times more effective than in low latitudes in producing global surface warming; (ii) identify the most excitable SST mode (neutral vector) resembling Interdecadal Pacific Oscillation; and (iii) estimate a time-invariant q-flux forcing needed for maintaining the GHG-induced SST warming pattern. The GRF experiments will be used to construct LRF for other variables to further explore climate sensitivities and feedbacks.« less

Balance between somatostatin and D2 receptor expression drives TSH-secreting adenoma response to somatostatin analogues and dopastatins.

PubMed

Gatto, Federico; Barbieri, Federica; Gatti, Monica; Wurth, Roberto; Schulz, Stefan; Ravetti, Jean-Louis; Zona, Gianluigi; Culler, Michael D; Saveanu, Alexandru; Giusti, Massimo; Minuto, Francesco; Hofland, Leo J; Ferone, Diego; Florio, Tullio

2012-03-01

First-line therapy for thyrotropin-secreting pituitary adenomas (TSHomas) is neurosurgery, while medical treatment rests mainly on somatostatin analogues. Clinically available sst(2) -preferring analogues, octreotide and lanreotide, induce normalization of hormone levels in approximately 90% of patients and tumour shrinkage in 45%. We evaluated somatostatin 1, 2, 3 and 5 and dopamine D2 receptor expression in tumour samples from three TSHomas, and the relationships between receptor expression, in vitro antiproliferative response and clinical data, including octreotide test and three months of therapy with octreotide long-acting repeatable (LAR). TSHoma cell proliferation was tested in vitro using octreotide, cabergoline and two chimeric compounds, BIM-23A760 and BIM-23A387. All patients showed significant TSH lowering to acute octreotide test, but a hormonal response to long-term treatment was observed in only two patients, showing a high sst(5) /sst(2) ratio. Patient 2, characterized by high expression of sst(2) and sst(1) and a relative lower expression of sst(5) , experienced tachyphylaxis after prolonged octreotide treatment. In vitro, the somatostatin/dopamine receptor agonist BIM-23A760 caused the highest antiproliferative effect among those tested. Combined treatment with octreotide and cabergoline displayed an additive effect of magnitude comparable to that of the other chimeric compound (BIM-23A387). Octreotide resistance was confirmed in cells isolated from the nonresponder patient, although it could be overcome by treatment with the chimeric compounds.   A high sst(5) /sst(2) ratio might be predictive of a positive outcome to long-term treatment with somatostatin analogues in TSHomas. Moreover, combined somatostatin and D(2) receptor targeting might be considered as a potential tool to improve the response rate in octreotide-resistant tumours. © 2012 Blackwell Publishing Ltd.

A Tropical View of Atlantic Multidecadal SST Variability over the Last Two Millennia

NASA Astrophysics Data System (ADS)

Wurtzel, J. B.; Black, D. E.; Thunell, R.; Peterson, L. C.; Tappa, E. J.; Rahman, S.

2011-12-01

Instrumental and proxy-reconstructions show the existence of a 60-80 year periodicity in Atlantic sea surface temperature (SST), known as the Atlantic Multidecadal Oscillation (AMO). The AMO is correlated with circum-tropical Atlantic climate phenomena such as Sahel and Nordeste rainfall, as well as Atlantic hurricane patterns. Though it has been suggested that the AMO is controlled by thermohaline circulation, much debate exists as to whether the SST fluctuations are a result of anthropogenic forcing or natural climate variability. Our ability to address this issue has been limited by instrumental SST records that rarely extend back more than 50-100 years and proxy reconstructions that are largely terrestrial-based. Here we present a high-resolution marine sediment-derived reconstruction of seasonal tropical Atlantic SSTs from the Cariaco Basin spanning the past two millennia that is correlated with instrumental SSTs and the AMO for the period of overlap. The full record demonstrates that seasonality is largely controlled by variations in winter/spring SST. Wavelet analysis of the proxy data suggest that variability in the 60-80 year band evolved 250 years ago, while 40-60 year periodicities dominate earlier parts of the record. At least over the last millennia, multidecadal- and centennial- scale SST variability in the tropical Atlantic appears related to Atlantic meridional overturning circulation (AMOC) fluctuations and its associated northward heat transport that in turn may be driven by solar variability. An inverse correlation between the tropical proxy annual average SST record and Δ14C indicates that the tropics experienced positive SST anomalies during times of reduced solar activity, possibly as a result of decreased AMOC strength (Figure 1).

Long-term changes in the Northwestern Atlantic and Mediterranean SST from 1982 to 2016: A contribution of the Operational Oceanography to the determination of the present day Climate

NASA Astrophysics Data System (ADS)

Artale, Vincenzo; Buongiorno Nardelli, Bruno; Marullo, Salvatore; Pisano, Andrea; Santoleri, Rosalia; Tronconi, Cristina

2017-04-01

Estimating long-term SST changes is crucial to evaluate global warming impact at regional scales. Here, we analyze the Mediterranean (MED) and the Northwestern Atlantic Box (NWA) SST changes over the last 34 years (1982 - 2016) by combining reprocessed (REP) and near-real-time (NRT) data. Actually, the Italian National Research Council (CNR) has recently produced daily (nighttime), 4 km resolution REP MED level 4 datasets (REP L4), also covering the adjacent Atlantic region, based on the latest Pathfinder v5.2 AVHRR dataset (1982-2012). These data represent the longest satellite MED SST L4 time series and are freely distributed through the European Copernicus Marine Environment Monitoring Service (CMEMS). However, as Pathfinder has not yet released an update of its product, the REP data end in 2012. To fill in the gap between 2013 and 2016, we investigated the possibility to extend the time series by using the Mediterranean near real time (NRT), multi-sensor L4 SST data at Ultra-High spatial Resolution (UHR) produced by CNR, which are distributed through CMEMS and now mirrored at GHRSST. Since this product is available since 2008, the consistency with the REP has been assessed. Combining the REP L4 data (1982-2012) and a bias-corrected version of the NRT L4 data (2013-2016), we built the SST time series and provided updated estimates of the MED and NWA SST trends. The analysis shows that The Atlantic Box and The Mediterranean Sea have similar trend behavior until 2008. Afterward the Mediterranean Sea SST continued to increase while the Atlantic Box persisted in its warming pause.

Assimilating Satellite SST Observations into a Diurnal Cycle Model

NASA Astrophysics Data System (ADS)

Pimentel, S.; Haines, K.; Nichols, N. K.

2006-12-01

The wealth of satellite sea surface temperature (SST) data now available opens the possibility of large improvements in SST estimation. However the use of such data is not straight forward; a major difficulty in assimilating satellite observations is that they represent a near surface temperature, whereas in ocean models the top level represents the temperature at a greater depth. During the day, under favourable conditions of clear skies and calm winds, the near surface temperature is often seen to have a diurnal cycle that is picked up in satellite observations. Current ocean models do not have the vertical or temporal resolution to adequately represent this daytime warming. The usual approach is to discard daytime observations as they are considered diurnally `corrupted'. A new assimilation technique is developed here that assimilates observations into a diurnal cycle model. The diurnal cycle of SSTs are modelled using a 1-D mixed layer model with fine near surface resolution and 6 hourly forcing from NWP analyses. The accuracy of the SST estimates are hampered by uncertainties in the forcing data. The extent of diurnal SST warming at a particular location and time is predominately governed by a non-linear response to cloud cover and sea surface wind speeds which greatly affect the air-sea fluxes. The method proposed here combines infrared and microwave SST satellite observations in order to derive corrections to the cloud cover and wind speed values over the day. By adjusting the forcing, SST estimation and air-sea fluxes should be improved and are at least more consistent with each other. This new technique for assimilating SST data can be considered a tool for producing more accurate diurnal warming estimates.

Influence of equatorial QBO (quasi-biennial oscillation) and SST (sea-surface temperature) on polar total ozone, and the 1990 Antarctic ozone hole

DOE Office of Scientific and Technical Information (OSTI.GOV)

Angell, J.K.

1990-09-01

Based on data through 1989, comparisons are made between the variation of total ozone at Resolute, Canada (75{degree}N) and South Pole, and the variation of low-stratospheric temperature at Singapore (reflecting the equatorial QBO) and SST in eastern equatorial Pacific (reflecting the ENSO phenomenon). Total-ozone variations at Resolute have been more closely related to the QBO, whereas the total-ozone variations at South Pole appear to have been almost equally related to QBO and SST. When the average of 50 mb and 30 mb June-July-August (JJA) values of Singapore temperature ({bar T}) increased from one year to the next, the decrease inmore » South Pole springtime total ozone for the same years averaged 21 {plus minus} 14% greater than when {bar T} decreased. When the JJA values of equatorial SST increased from one year to the next, the decrease in South Pole springtime total ozone for the same years averaged 18 {plus minus} 12% greater than when SST decreased. In the 6 cases when JJA values of both Singapore {bar T} and equatorial SST increased from one year to the next, the spring values of South Pole total ozone have decreased, whereas in the 6 cases when both {bar T} and SST decreased from one year to the next, South Pole total ozone has increased. Both Singapore {bar T} and equatorial SST will probably be warmer in JJA of 1990 than they were in JJA of 1989 suggesting, based on these previous relations, an even deeper Antarctic ozone hole in 1990 than in 1989 and ending the biennial variation in depth of the hole of the last 6 years.« less

Late Holocene Sea Surface Temperature Trends in the Eastern Tropical Pacific

NASA Astrophysics Data System (ADS)

Rustic, G. T.; Koutavas, A.; Marchitto, T. M., Jr.

2015-12-01

The Eastern Tropical Pacific (ETP) is a highly dynamic ocean region capable of exerting influencing on global climate as illustrated by the El Niño-Southern Oscillation (ENSO). The sea surface temperature (SST) history of this region in past millennia is poorly constrained due to the lack of in situ records with appropriate resolution. Here we present a ~2700 year sub-centennially resolved SST reconstruction from Mg/Ca ratios of the planktonic foraminifer Globigerinoides ruber from Galápagos sediments. The ETP SST record exhibits a long-term cooling trend of over 0.2°C/ky that is similar to Northern Hemisphere multi-proxy temperature trends suggesting a common origin, likely due to insolation forcing. The ETP remains in-phase with Northern Hemisphere climate records through the warm Roman Climate Optimum (~0-400CE), cooler Dark Ages Cold Period (~450-850CE), and through the peak warming of the Medieval Climate Anomaly (900-1150 CE) when SST is within error of modern. Following peak MCA, the ETP cooled rapidly and then rebounded at ~1500 CE during the coldest portion of the Little Ice Age. Overall the data suggest an out-of-phase relationship during much of the last millennium, which we attribute to dynamical adjustments consistent with the "dynamical ocean thermostat" mechanism. Further evidence for these dynamical adjustments comes from reconstructions of the east-west zonal SST gradient using existing Mg/Ca SST reconstructions from the western Pacific warm pool. The last millennium has been the most dynamic period over the past 2700 years, with significant (~1 °C) SST variability in the ETP and modulation of the zonal gradient. A combination of dynamical and thermodynamic mechanisms are invoked to explain the region's complex SST history.

Expression of Somatostatin, cortistatin, and their receptors, as well as dopamine receptors, but not of neprilysin, are reduced in the temporal lobe of Alzheimer's disease patients.

PubMed

Gahete, Manuel D; Rubio, Alicia; Durán-Prado, Mario; Avila, Jesús; Luque, Raúl M; Castaño, Justo P

2010-01-01

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by severe cognitive deficit, wherein the impairment of episodic memory is the major hallmark. AD patients exhibit augmented accumulation of amyloid-beta (Abeta) and hyperphosphorylated tau protein in specific brain regions. In addition, several neuropeptides/neurotransmitter axes clearly associated with cognitive processes, Abeta turnover, and tau phosphorylation have also been found to be impaired in AD, such as somatostatin (SST)/cortistatin (CST) and dopamine (DA) systems. However, to date there is no precise quantitative data on the expression of these systems in the human brain of AD and normal patients. Here we measured by quantitative real-time PCR the mRNA levels of SST/CST, their receptors (sst1-5 and DA receptors (drd1-5) in addition to neprilysin (a SST-regulated enzyme involved in Abeta degradation) in three regions of the temporal lobe, one of the cortical regions most severely affected by AD. Our results reveal that some components of SST/CST- and DA-axes are divergently altered in the three areas of AD patients. Despite this region-specific regulation, an overall, common reduction of these systems was observed in the temporal lobe of AD patients. Conversely, neprilysin expression was not altered in AD, suggesting that Abeta accumulation observed in AD is due to a lack of neprilysin activation by SST rather than to a reduction of its expression. Collectively, our results define a comprehensive scenario wherein reduction of ssts, drds, and sst ligands SST and CST, could be involved, at least in part, in some of the more important defects observed in AD.

Impact of Monsoon to Aquatic Productivity and Fish Landing at Pesawaran Regency Waters

NASA Astrophysics Data System (ADS)

Kunarso; Zainuri, Muhammad; Ario, Raden; Munandar, Bayu; Prayogi, Harmon

2018-02-01

Monsoon variability influences the productivity processes in the ocean and has different responses in each waters. Furthermore, variability of marine productivity affects to the fisheries resources fluctuation. This research has conducted using descriptive method to investigate the consequences of monsoon variability to aquatic productivity, sea surface temperature (SST), fish catches, and fish season periods at Pesawaran Regency waters, Lampung. Variability of aquatic productivity was determined based on chlorophyll-a indicator from MODIS satellite images. Monsoon variability was governed based on wind parameters and fish catches from fish landing data of Pesawaran fish market. The result showed that monsoon variability had affected to aquatic productivity, SST, and fish catches at Pesawaran Regency waters. Maximum wind speed and lowest SST occurred twice in a year, December to March and August to October, which the peaks were on January (2.55 m/s of wind speed and 29.66°C of SST) and September (2.44 m/s of wind speed and 29.06°C of SST). Also, Maximum aquatic productivity happened on January to March and July to September, which it was arisen simultaneously with maximum wind speed and the peaks was 0.74 mg/m3 and 0.78 mg/m3, on February and August respectively. The data showed that fish catches decreased along with strong wind speed and low SST. However, when weak wind speed and high SST occurred, fish catches increased. The correlation between Catch per Unit Effort (CPUE) with SST, wind speed, and chlorophyll-a was at value 0.76, -0.67, and -0.70, respectively. The high rate fish catches in Pesawaran emerged on March-May and September-December.

Inter-decadal change of the lagged inter-annual relationship between local sea surface temperature and tropical cyclone activity over the western North Pacific

NASA Astrophysics Data System (ADS)

Zhao, Haikun; Wu, Liguang; Raga, G. B.

2018-02-01

This study documents the inter-decadal change of the lagged inter-annual relationship between the TC frequency (TCF) and the local sea surface temperature (SST) in the western North Pacific (WNP) during 1979-2014. An abrupt shift of the lagged relationship between them is observed to occur in 1998. Before the shift (1979-1997), a moderately positive correlation (0.35) between previous-year local SST and TCF is found, while a significantly negative correlation (- 0.71) is found since the shift (1998-2014). The inter-decadal change of the lagged relationship between TCF and local SST over the WNP is also accompanied by an inter-decadal change in the lagged inter-annual relationship between large-scale factors affecting TCs and local SST over the WNP. During 1998-2014, the previous-year local SST shows a significant negative correlation with the mid-level moisture and a significant positive correlation with the vertical wind shear over the main development region of WNP TC genesis. Almost opposite relationships are seen during 1979-1997, with a smaller magnitude of the correlation coefficients. These changes are consistent with the changes of the lagged inter-annual relationship between upper- and lower-level winds and local SST over the WNP. Analyses further suggests that the inter-decadal shift of the lagged inter-annual relationship between WNP TCF and local SST may be closely linked to the inter-decadal change of inter-annual SST transition over the tropical central-eastern Pacific associated with the climate regime shift in the late 1990s. Details on the underlying physical process need further investigation using observations and simulations.

Opposing Effects of Acute versus Chronic Blockade of Frontal Cortex Somatostatin-Positive Inhibitory Neurons on Behavioral Emotionality in Mice

PubMed Central

Soumier, Amelie; Sibille, Etienne

2014-01-01

Reduced expression of somatostatin (SST) is reported across chronic brain conditions including major depression and normal aging. SST is a signaling neuropeptide and marker of gamma-amino butyric acid (GABA) neurons, which specifically inhibit pyramidal neuron dendrites. Studies in auditory cortex suggest that chronic reduction in dendritic inhibition induces compensatory homeostatic adaptations that oppose the effects of acute inhibition. Whether such mechanisms occur in frontal cortex (FC) and affect behavioral outcome is not known. Here, we used two complementary viral vector strategies to examine the effects of acute vs chronic inhibition of SST-positive neurons on behavioral emotionality in adult mice. SST-IRES-Cre mice were injected in FC (prelimbic/precingulate) with CRE-dependent adeno-associated viral (AAV) vector encoding the engineered Gi/o-coupled human muscarinic M4 designer receptor exclusively activated by a designer drug (DREADD-hM4Di) or a control reporter (AAV-DIO-mCherry) for acute or chronic cellular inhibition. A separate cohort was injected with CRE-dependent AAV vectors expressing diphtheria toxin (DTA) to selectively ablate FC SST neurons. Mice were assessed for anxiety- and depressive-like behaviors (defined as emotionality). Results indicate that acute inhibition of FC SST neurons increased behavioral emotionality, whereas chronic inhibition decreased behavioral emotionality. Furthermore, ablation of FC SST neurons also decreased behavioral emotionality under baseline condition and after chronic stress. Together, our results reveal opposite effects of acute and chronic inhibition of FC SST neurons on behavioral emotionality and suggest the recruitment of homeostatic plasticity mechanisms that have implications for understanding the neurobiology of chronic brain conditions affecting dendritic-targeting inhibitory neurons. PMID:24690741

Opposing effects of acute versus chronic blockade of frontal cortex somatostatin-positive inhibitory neurons on behavioral emotionality in mice.

PubMed

Soumier, Amelie; Sibille, Etienne

2014-08-01

Reduced expression of somatostatin (SST) is reported across chronic brain conditions including major depression and normal aging. SST is a signaling neuropeptide and marker of gamma-amino butyric acid (GABA) neurons, which specifically inhibit pyramidal neuron dendrites. Studies in auditory cortex suggest that chronic reduction in dendritic inhibition induces compensatory homeostatic adaptations that oppose the effects of acute inhibition. Whether such mechanisms occur in frontal cortex (FC) and affect behavioral outcome is not known. Here, we used two complementary viral vector strategies to examine the effects of acute vs chronic inhibition of SST-positive neurons on behavioral emotionality in adult mice. SST-IRES-Cre mice were injected in FC (prelimbic/precingulate) with CRE-dependent adeno-associated viral (AAV) vector encoding the engineered Gi/o-coupled human muscarinic M4 designer receptor exclusively activated by a designer drug (DREADD-hM4Di) or a control reporter (AAV-DIO-mCherry) for acute or chronic cellular inhibition. A separate cohort was injected with CRE-dependent AAV vectors expressing diphtheria toxin (DTA) to selectively ablate FC SST neurons. Mice were assessed for anxiety- and depressive-like behaviors (defined as emotionality). Results indicate that acute inhibition of FC SST neurons increased behavioral emotionality, whereas chronic inhibition decreased behavioral emotionality. Furthermore, ablation of FC SST neurons also decreased behavioral emotionality under baseline condition and after chronic stress. Together, our results reveal opposite effects of acute and chronic inhibition of FC SST neurons on behavioral emotionality and suggest the recruitment of homeostatic plasticity mechanisms that have implications for understanding the neurobiology of chronic brain conditions affecting dendritic-targeting inhibitory neurons.

A spurious warming trend in the NMME equatorial Pacific SST hindcasts

NASA Astrophysics Data System (ADS)

Shin, Chul-Su; Huang, Bohua

2017-06-01

Using seasonal hindcasts of six different models participating in the North American Multimodel Ensemble project, the trend of the predicted sea surface temperature (SST) in the tropical Pacific for 1982-2014 at each lead month and its temporal evolution with respect to the lead month are investigated for all individual models. Since the coupled models are initialized with the observed ocean, atmosphere, land states from observation-based reanalysis, some of them using their own data assimilation process, one would expect that the observed SST trend is reasonably well captured in their seasonal predictions. However, although the observed SST features a weak-cooling trend for the 33-year period with La Niña-like spatial pattern in the tropical central-eastern Pacific all year round, it is demonstrated that all models having a time-dependent realistic concentration of greenhouse gases (GHG) display a warming trend in the equatorial Pacific that amplifies as the lead-time increases. In addition, these models' behaviors are nearly independent of the starting month of the hindcasts although the growth rates of the trend vary with the lead month. This key characteristic of the forecasted SST trend in the equatorial Pacific is also identified in the NCAR CCSM3 hindcasts that have the GHG concentration for a fixed year. This suggests that a global warming forcing may not play a significant role in generating the spurious warming trend of the coupled models' SST hindcasts in the tropical Pacific. This model SST trend in the tropical central-eastern Pacific, which is opposite to the observed one, causes a developing El Niño-like warming bias in the forecasted SST with its peak in boreal winter. Its implications for seasonal prediction are discussed.

The absence of an Atlantic imprint on the multidecadal variability of wintertime European temperature.

PubMed

Yamamoto, Ayako; Palter, Jaime B

2016-03-15

Northern Hemisphere climate responds sensitively to multidecadal variability in North Atlantic sea surface temperature (SST). It is therefore surprising that an imprint of such variability is conspicuously absent in wintertime western European temperature, despite that Europe's climate is strongly influenced by its neighbouring ocean, where multidecadal variability in basin-average SST persists in all seasons. Here we trace the cause of this missing imprint to a dynamic anomaly of the atmospheric circulation that masks its thermodynamic response to SST anomalies. Specifically, differences in the pathways Lagrangian particles take to Europe during anomalous SST winters suppress the expected fluctuations in air-sea heat exchange accumulated along those trajectories. Because decadal variability in North Atlantic-average SST may be driven partly by the Atlantic Meridional Overturning Circulation (AMOC), the atmosphere's dynamical adjustment to this mode of variability may have important implications for the European wintertime temperature response to a projected twenty-first century AMOC decline.

Estimating Sea Surface Temperature Measurement Methods Using Characteristic Differences in the Diurnal Cycle

NASA Astrophysics Data System (ADS)

Carella, G.; Kennedy, J. J.; Berry, D. I.; Hirahara, S.; Merchant, C. J.; Morak-Bozzo, S.; Kent, E. C.

2018-01-01

Lack of reliable observational metadata represents a key barrier to understanding sea surface temperature (SST) measurement biases, a large contributor to uncertainty in the global surface record. We present a method to identify SST measurement practice by comparing the observed SST diurnal cycle from individual ships with a reference from drifting buoys under similar conditions of wind and solar radiation. Compared to existing estimates, we found a larger number of engine room-intake (ERI) reports post-World War II and in the period 1960-1980. Differences in the inferred mixture of observations lead to a systematic warmer shift of the bias adjusted SST anomalies from 1980 compared to previous estimates, while reducing the ensemble spread. Changes in mean field differences between bucket and ERI SST anomalies in the Northern Hemisphere over the period 1955-1995 could be as large as 0.5°C and are not well reproduced by current bias adjustment models.

Tropical cyclone rainfall area controlled by relative sea surface temperature

PubMed Central

Lin, Yanluan; Zhao, Ming; Zhang, Minghua

2015-01-01

Tropical cyclone rainfall rates have been projected to increase in a warmer climate. The area coverage of tropical cyclones influences their impact on human lives, yet little is known about how tropical cyclone rainfall area will change in the future. Here, using satellite data and global atmospheric model simulations, we show that tropical cyclone rainfall area is controlled primarily by its environmental sea surface temperature (SST) relative to the tropical mean SST (that is, the relative SST), while rainfall rate increases with increasing absolute SST. Our result is consistent with previous numerical simulations that indicated tight relationships between tropical cyclone size and mid-tropospheric relative humidity. Global statistics of tropical cyclone rainfall area are not expected to change markedly under a warmer climate provided that SST change is relatively uniform, implying that increases in total rainfall will be confined to similar size domains with higher rainfall rates. PMID:25761457

Estimation of sea surface temperature from remote sensing in the 11-13 micron window region

NASA Technical Reports Server (NTRS)

Prabhakara, C.; Dalu, G.; Kunde, V. G.

1974-01-01

The Nimbus 3 and 4 IRIS spectral data in the 11-13 micron water vapor window region are analyzed to determine the sea surface temperature (SST). The high spectral resolution data of IRIS are averaged over approximately 1 micron wide intervals to simulate channels of a radiometer to measure the SST. Three channels are utilized to measure SST over cloud-free oceans. However, two of these channels are sufficient in routine SST determination. The differential absorption properties of water vapor in the two channels enable one to determine the water vapor absorption correction without detailed knowledge of the vertical profiles of temperature and water vapor. The feasibility of determining the SST is demonstrated globally with Nimbus 3 data where cloud-free areas can be selected with the help of albedo data from the MRIR experiment on board the same satellite.

Sea surface temperature anomalies, planetary waves, and air-sea feedback in the middle latitudes

NASA Technical Reports Server (NTRS)

Frankignoul, C.

1985-01-01

Current analytical models for large-scale air-sea interactions in the middle latitudes are reviewed in terms of known sea-surface temperature (SST) anomalies. The scales and strength of different atmospheric forcing mechanisms are discussed, along with the damping and feedback processes controlling the evolution of the SST. Difficulties with effective SST modeling are described in terms of the techniques and results of case studies, numerical simulations of mixed-layer variability and statistical modeling. The relationship between SST and diabatic heating anomalies is considered and a linear model is developed for the response of the stationary atmosphere to the air-sea feedback. The results obtained with linear wave models are compared with the linear model results. Finally, sample data are presented from experiments with general circulation models into which specific SST anomaly data for the middle latitudes were introduced.

A feasibility study on the implementation of satellite-to-satellite tracking around a small near-Earth object

NASA Astrophysics Data System (ADS)

Church, Christopher J.

Near-earth objects (NEOs) are asteroids and comets that have a perihelion distance of less than 1.3 astronomical units (AU). There are currently more than 10,000 known NEOs. The majority of these objects are less than 1 km in diameter. Despite the number of NEOs, little is known about most of them. Characterizing these objects is a crucial component in developing a thorough understanding of solar system evolution, human exploration, exploitation of asteroid resources, and threat mitigation. Of particular interest is characterizing the internal structure of NEOs. While ground-based methods exist for characterizing the internal structure of NEOs, the information that can be gleaned from such studies is limited and often accompanied by large uncertainty. An alternative is to use in situ studies to examine an NEO's shape and gravity field, which can be used to assess its internal structure. This thesis investigates the use of satellite-to-satellite tracking (SST) to map the gravity field of a small NEO on the order of 500 m or less. An analysis of the mission requirements of two previously flown SST missions, GRACE and GRAIL, is conducted. Additionally, a simulation is developed to investigate the dynamics of SST in the vicinity of a small NEO. This simulation is then used to simulate range and range-rate data in the strongly perturbed environment of the small NEO. These data are used in conjunction with the analysis of the GRACE and GRAIL missions to establish a range of orbital parameters that can be used to execute a SST mission around a small NEO. Preliminary mission requirements for data collection and orbital correction maneuvers are also established. Additionally, the data are used to determine whether or not proven technology can be used to resolve the expected range and range-rate measurements. It is determined that the orbit semi-major axis for each spacecraft should be approximately 100% to 200% of the NEO's mean diameter and the two spacecraft should be in circular, near polar orbits. This configuration will produce trajectories, which exhibit reasonable stability over a period of roughly 24 hours. Corrective maneuvers will therefore be required with a frequency of approximately once per day. Due to the potentially rapid changes caused by the highly perturbed environment, it is likely that these maneuvers will need to be made autonomously. During the period between corrective maneuvers SST data collection will be possible. The expected range and range-rate measurements will be on the order of +/-10-5 m and +/-10 -5 m/s respectively and can be resolved using proven technology.

Error Estimation in an Optimal Interpolation Scheme for High Spatial and Temporal Resolution SST Analyses

NASA Technical Reports Server (NTRS)

Rigney, Matt; Jedlovec, Gary; LaFontaine, Frank; Shafer, Jaclyn

2010-01-01

Heat and moisture exchange between ocean surface and atmosphere plays an integral role in short-term, regional NWP. Current SST products lack both spatial and temporal resolution to accurately capture small-scale features that affect heat and moisture flux. NASA satellite is used to produce high spatial and temporal resolution SST analysis using an OI technique.

Spherical harmonic expansion of the Levitus Sea surface topography

NASA Technical Reports Server (NTRS)

Engelis, Theodossios

1987-01-01

Prior information for the stationary sea surface topography (SST) may be needed in altimetric solutions that intend to simultaneously improve the gravity field and determine the SST. For this purpose the oceanographically derived SST estimates are represented by a spherical harmonic expansion. The spherical harmonic coefficients are computed from a least squares adjustment of the data covering the majority of the oceanic regions of the world. Several tests are made to determine the optimum maximum degree of solution and the best configuration of the geometry of the data in order to obtain a solution that fits the data and also provides a good spectral representation of the SST.

Interleukin-33/ST2 system attenuates aldosterone-induced adipogenesis and inflammation.

PubMed

Martínez-Martínez, Ernesto; Cachofeiro, Victoria; Rousseau, Elodie; Álvarez, Virginia; Calvier, Laurent; Fernández-Celis, Amaya; Leroy, Céline; Miana, María; Jurado-López, Raquel; Briones, Ana M; Jaisser, Frederic; Zannad, Faiez; Rossignol, Patrick; López-Andrés, Natalia

2015-08-15

Interleukin-33 (IL-33) but not soluble ST2 (sST2) exerts anti-inflammatory and protective effects in several tissues. Aldosterone, a proinflammatory mediator which promotes adipogenesis, is elevated in obese patients. The aim of this study was to investigate the interactions between IL-33/ST2 system and Aldosterone in adipose tissue. Rats fed a high fat diet presented increased sST2 expression, diminished IL-33/sST2 ratio and enhanced levels of differentiation and inflammation in adipose tissue as compared to controls. A similar pattern was observed in adipose tissue from C57BL/6 Aldosterone-treated mice. In both animal models, Aldosterone was correlated with sST2. Treatment of 3T3-L1 adipocytes with IL-33 delayed adipocyte differentiation diminished lipid accumulation and decreased inflammation. Aldosterone decreased IL-33 and increased sST2 expressions in differentiated adipocytes. Aldosterone-induced adipocyte differentiation and inflammation were blocked by IL-33 treatment, but sST2 did not exert any effects. The crosstalk between IL-33/ST2 and Aldosterone could be relevant in the metabolic consequences of obesity. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Analyzing the Effects of Climate Change on Sea Surface Temperature in Monitoring Coral Reef Health in the Florida Keys Using Sea Surface Temperature Data

NASA Technical Reports Server (NTRS)

Jones, Jason; Burbank, Renane; Billiot, Amanda; Schultz, Logan

2011-01-01

This presentation discusses use of 4 kilometer satellite-based sea surface temperature (SST) data to monitor and assess coral reef areas of the Florida Keys. There are growing concerns about the impacts of climate change on coral reef systems throughout the world. Satellite remote sensing technology is being used for monitoring coral reef areas with the goal of understanding the climatic and oceanic changes that can lead to coral bleaching events. Elevated SST is a well-documented cause of coral bleaching events. Some coral monitoring studies have used 50 km data from the Advanced Very High Resolution Radiometer (AVHRR) to study the relationships of sea surface temperature anomalies to bleaching events. In partnership with NOAA's Office of National Marine Sanctuaries and the University of South Florida's Institute for Marine Remote Sensing, this project utilized higher resolution SST data from the Terra's Moderate Resolution Imaging Spectroradiometer (MODIS) and AVHRR. SST data for 2000-2010 was employed to compute sea surface temperature anomalies within the study area. The 4 km SST anomaly products enabled visualization of SST levels for known coral bleaching events from 2000-2010.

Assessing the applicability of organic SST proxies in an upwelling region (Arabian Sea)

NASA Astrophysics Data System (ADS)

Lattaud, J.; van Erk, M. R.; Reichart, G. J.; Schulz, H.; S Sinninghe Damsté, J.; Schouten, S.

2017-12-01

Multiple organic proxies have the potential to reconstruct sea surface temperature (SST), but their behaviour is not completely understood within upwelling areas. This holds in particular for the recently developed Long chain Diol Index1 (LDI), based on the ratio of 1,15-diols over 1,13-diols, both likely produced by Eustigmatophytes. We tested the applicability of the LDI by comparing it to the more established temperature proxies TEX86 and Uk¢37 in a sediment core (spanning the last 76 ky) from the northern Arabian Sea and in surface sediments (Pakistan margin). In the surface sediments, Uk¢37- and LDI-SSTs agree well with annual mean SST, but the TEX86-SST substantially overestimates SST. A better agreement is observed, when the 0-200 m TEX86 calibration is used, suggesting TEX86 reflects subsurface temperatures. The results from the sediment core reveal that the SST records differ in absolute reconstructed temperature and show different patterns. TEX86 subsurface temperatures show a continuous increase toward the Holocene and no stadial/interstadial differences, while the LDI-SST is constant around 26°C with the exception of some short-term cooling events during periods of intensified upwelling. The Uk¢37-SST varies between 22 and 26°C and follows the global δ18Obenthic foram curve and thus is representing mean annual SST in this region3. During stadials, the reduced monsoon and low upwelling intensity resulted in warming of the subsurface waters2, as indicated by higher TEX86 temperatures, while global cooling led to colder surface waters as reflected in lower Uk¢37-SSTs, thus reducing the thermal gradient in the water column2. During the interstadials, which are periods of strong upwelling3, there is a high proportion of 1,14-diols (>40%). This probably disturbs the LDI-SST signal because the diatoms that produce the 1,14-diols are also generating small amounts of the 1,13-diols4. This suggests that care has to be taken in applying the LDI in upwelling regions. References 1Rampen et al., 2012 2Tierney et al., 2015 3Emeis et al., 1995 4Rampen et al., 2007

Role of Soluble ST2 Levels and Beta-Blockers Dosage on Cardiovascular Events of Patients with Unselected ST-Segment Elevation Myocardial Infarction

PubMed Central

Huang, Wei-Ping; Zheng, Xuan; He, Lei; Su, Xi; Liu, Cheng-Wei; Wu, Ming-Xiang

2018-01-01

Background: Serum soluble ST2 (sST2) levels are elevated early after acute myocardial infarction and are related to adverse left ventricular (LV) remodeling and cardiovascular outcomes in ST-segment elevation myocardial infarction (STEMI). Beta-blockers (BB) have been shown to improve LV remodeling and survival. However, the relationship between sST2, final therapeutic BB dose, and cardiovascular outcomes in STEMI patients remains unknown. Methods: A total of 186 STEMI patients were enrolled at the Wuhan Asia Heart Hospital between January 2015 and June 2015. All patients received standard treatment and were followed up for 1 year. Serum sST2 was measured at baseline. Patients were divided into four groups according to their baseline sST2 values (high >56 ng/ml vs. low ≤56 ng/ml) and final therapeutic BB dose (high ≥47.5 mg/d vs. low <47.5 mg/d). Cox regression analyses were performed to determine whether sST2 and BB were independent risk factors for cardiovascular events in STEMI. Results: Baseline sST2 levels were positively correlated with heart rate (r = 0.327, P = 0.002), Killip class (r = 0.408, P = 0.000), lg N-terminal prohormone B-type natriuretic peptide (r = 0.467, P = 0.000), lg troponin I (r = 0.331, P = 0.000), and lg C-reactive protein (r = 0.307, P = 0.000) and negatively correlated to systolic blood pressure (r = −0.243, P = 0.009) and LV ejection fraction (r = −0.402, P = 0.000). Patients with higher baseline sST2 concentrations who were not titrated to high-dose BB therapy (P < 0.0001) had worse outcomes. Baseline high sST2 (hazard ratio [HR]: 2.653; 95% confidence interval [CI]: 1.201–8.929; P = 0.041) and final low BB dosage (HR: 1.904; 95% CI, 1.084–3.053; P = 0.035) were independent predictors of cardiovascular events in STEMI. Conclusions: High baseline sST2 levels and final low BB dosage predicted cardiovascular events in STEMI. Hence, sST2 may be a useful biomarker in cardiac pathophysiology. PMID:29786039

Latitudinal and Longitudinal Basin-scale Surface Salinity Contrasts and Freshwater Transport by Ocean Thermohaline Circulation

NASA Astrophysics Data System (ADS)

Seidov, D.; Haupt, B. J.

2003-12-01

The role of sea surface salinity (SSS) contrasts in maintaining vigorous global ocean thermohaline circulation (THC) is revisited. Relative importance of different generalizations of sea surface conditions in climate studies is explored. In numerical experiments using an ocean general circulation model, we have aggregated the observed sea surface temperature (SST) and SSS in several different ways: we used observed unchanged SST with SSS taken as constant (34.25 psu) everywhere; SST unchanged, and SSS zonally averaged globally, i.e., in the whole World Ocean; SST averaged globally, and SSS unchanged; SST zonally averaged globally and SSS zonally averaged basin-wide in individual basins, i.e., in the Atlantic, Indian, Pacific, and Southern Oceans separately; and, finally, both SST and SSS zonally averaged in individual basins. Global zonal averaging removes all longitudinal differences in sea surface climatology among ocean basins. However, latitudinal profiles of zonally averaged parameters preserve the main character of large-scale equator-to-pole sea surface variability. Basin-wide zonal averaging does an even better job of preserving latitudinal distributions within each basin. The results of the experiments could hardly be anticipated a priory. Surprisingly, SST could be used as a 2-D field, or as a zonally-averaged field without much difference in the THC dynamics. Moreover, SST could be averaged either globally, or basin-wide, and it also did not change the overall character of THC. At the same time, THC responded vigorously to how the SSS has been changed. It appeared that the THC structure with the globally averaged SST and basin-wide averaged SSS was very close to the one obtained in the control run (control run operates with 2-D observed SST and SSS). Our main conclusion is that ocean-wide inter-basin sea surface salinity contrasts serve as the major controlling element in global thermohaline circulation. Thermal inter-basin contrasts, as well as longitudinal variation in SSS, are less important than latitudinal thermal gradients and inter-basin salinity contrasts. Details of SSS also decrease in importance as soon as its inter-basin contrasts are retained. This is especially important for paleoclimate and future climate simulations, as only the large-scale inter-basin contrasts of the sea surface conditions really matter.

Impact of SST on heavy rainfall events on eastern Adriatic during SOP1 of HyMeX

NASA Astrophysics Data System (ADS)

Ivatek-Šahdan, Stjepan; Stanešić, Antonio; Tudor, Martina; Odak Plenković, Iris; Janeković, Ivica

2018-02-01

The season of late summer and autumn is favourable for intensive precipitation events (IPE) in the central Mediterranean. During that period the sea surface is warm and contributes to warming and moistening of the lowest portion of the atmosphere, particularly the planetary boundary layer (PBL). Adriatic sea is surrounded by mountains and the area often receives substantial amounts of precipitation in short time (24 h). The IPEs are a consequence of convection triggered by topography acting on the southerly flow that has brought the unstable air to the coastline. Improvement in prediction of high impact weather events is one of the goals of The Hydrological cycle in the Mediterranean eXperiment (HyMeX). This study examines how precipitation patterns change in response to different SST forcing. We focus on the IPEs that occurred on the eastern Adriatic coast during the first HyMeX Special observing period (SOP1, 6 September to 5 November 2012). The operational forecast model ALADIN uses the same SST as the global meteorological model (ARPEGE from Meteo France), as well as the forecast lateral boundary conditions (LBCs). First we assess the SST used by the operational atmospheric model ALADIN and compare it to the in situ measurements, ROMS ocean model, OSTIA and MUR analyses. Results of this assessment show that SST in the eastern Adriatic was overestimated by up to 10 K during HyMeX SOP1 period. Then we examine the sensitivity of 8 km and 2 km resolution forecasts of IPEs to the changes in the SST during whole SOP1 with special attention to the intensive precipitation event in Rijeka. Forecast runs in both resolutions are performed for the whole SOP1 using different SST fields prescribed at initial time and kept constant during the model forecast. Categorical verification of 24 h accumulated precipitation did not show substantial improvement in verification scores when more realistic SST was used. Furthermore, the results show that the impact of introducing improved SST in the analysis on the precipitation forecast varies for different cases. There is generally a larger sensitivity to the SST in high resolution than in the lower one, although the forecast period of the latter is longer.

The influence of sea surface temperature on the intensity and associated storm surge of tropical cyclone Yasi: a sensitivity study

NASA Astrophysics Data System (ADS)

Lavender, Sally L.; Hoeke, Ron K.; Abbs, Deborah J.

2018-03-01

Tropical cyclones (TCs) result in widespread damage associated with strong winds, heavy rainfall and storm surge. TC Yasi was one of the most powerful TCs to impact the Queensland coast since records began. Prior to Yasi, the SSTs in the Coral Sea were higher than average by 1-2 °C, primarily due to the 2010/2011 La Niña event. In this study, a conceptually simple idealised sensitivity analysis is performed using a high-resolution regional model to gain insight into the influence of SST on the track, size, intensity and associated rainfall of TC Yasi. A set of nine simulations with uniform SST anomalies of between -4 and 4 °C applied to the observed SSTs are analysed. The resulting surface winds and pressure are used to force a barotropic storm surge model to examine the influence of SST on the associated storm surge of TC Yasi. An increase in SST results in an increase in intensity, precipitation and integrated kinetic energy of the storm; however, there is little influence on track prior to landfall. In addition to an increase in precipitation, there is a change in the spatial distribution of precipitation as the SST increases. Decreases in SSTs result in an increase in the radius of maximum winds due to an increase in the asymmetry of the storm, although the radius of gale-force winds decreases. These changes in the TC characteristics also lead to changes in the associated storm surge. Generally, cooler (warmer) SSTs lead to reduced (enhanced) maximum storm surges. However, the increase in surge reaches a maximum with an increase in SST of 2 °C. Any further increase in SST does not affect the maximum surge but the total area and duration of the simulated surge increases with increasing upper ocean temperatures. A large decrease in maximum storm surge height occurs when a negative SST anomaly is applied, suggesting if TC Yasi had occurred during non-La Niña conditions the associated storm surge may have been greatly diminished, with a decrease in storm surge height of over 3 m when the SST is reduced by 2 °C. In summary, increases in SST lead to an increase in the potential destructiveness of TCs with regard to intensity, precipitation and storm surge, although this relationship is not linear.

Sho-saiko-to, a traditional herbal medicine, regulates gene expression and biological function by way of microRNAs in primary mouse hepatocytes

PubMed Central

2014-01-01

Background Sho-saiko-to (SST) (also known as so-shi-ho-tang or xiao-chai-hu-tang) has been widely prescribed for chronic liver diseases in traditional Oriental medicine. Despite the substantial amount of clinical evidence for SST, its molecular mechanism has not been clearly identified at a genome-wide level. Methods By using a microarray, we analyzed the temporal changes of messenger RNA (mRNA) and microRNA expression in primary mouse hepatocytes after SST treatment. The pattern of genes regulated by SST was identified by using time-series microarray analysis. The biological function of genes was measured by pathway analysis. For the identification of the exact targets of the microRNAs, a permutation-based correlation method was implemented in which the temporal expression of mRNAs and microRNAs were integrated. The similarity of the promoter structure between temporally regulated genes was measured by analyzing the transcription factor binding sites in the promoter region. Results The SST-regulated gene expression had two major patterns: (1) a temporally up-regulated pattern (463 genes) and (2) a temporally down-regulated pattern (177 genes). The integration of the genes and microRNA demonstrated that 155 genes could be the targets of microRNAs from the temporally up-regulated pattern and 19 genes could be the targets of microRNAs from the temporally down-regulated pattern. The temporally up-regulated pattern by SST was associated with signaling pathways such as the cell cycle pathway, whereas the temporally down-regulated pattern included drug metabolism-related pathways and immune-related pathways. All these pathways could be possibly associated with liver regenerative activity of SST. Genes targeted by microRNA were moreover associated with different biological pathways from the genes not targeted by microRNA. An analysis of promoter similarity indicated that co-expressed genes after SST treatment were clustered into subgroups, depending on the temporal expression patterns. Conclusions We are the first to identify that SST regulates temporal gene expression by way of microRNA. MicroRNA targets and non-microRNA targets moreover have different biological roles. This functional segregation by microRNA would be critical for the elucidation of the molecular activities of SST. PMID:24410935

Sho-saiko-to, a traditional herbal medicine, regulates gene expression and biological function by way of microRNAs in primary mouse hepatocytes.

PubMed

Song, Kwang Hoon; Kim, Yun Hee; Kim, Bu-Yeo

2014-01-11

Sho-saiko-to (SST) (also known as so-shi-ho-tang or xiao-chai-hu-tang) has been widely prescribed for chronic liver diseases in traditional Oriental medicine. Despite the substantial amount of clinical evidence for SST, its molecular mechanism has not been clearly identified at a genome-wide level. By using a microarray, we analyzed the temporal changes of messenger RNA (mRNA) and microRNA expression in primary mouse hepatocytes after SST treatment. The pattern of genes regulated by SST was identified by using time-series microarray analysis. The biological function of genes was measured by pathway analysis. For the identification of the exact targets of the microRNAs, a permutation-based correlation method was implemented in which the temporal expression of mRNAs and microRNAs were integrated. The similarity of the promoter structure between temporally regulated genes was measured by analyzing the transcription factor binding sites in the promoter region. The SST-regulated gene expression had two major patterns: (1) a temporally up-regulated pattern (463 genes) and (2) a temporally down-regulated pattern (177 genes). The integration of the genes and microRNA demonstrated that 155 genes could be the targets of microRNAs from the temporally up-regulated pattern and 19 genes could be the targets of microRNAs from the temporally down-regulated pattern. The temporally up-regulated pattern by SST was associated with signaling pathways such as the cell cycle pathway, whereas the temporally down-regulated pattern included drug metabolism-related pathways and immune-related pathways. All these pathways could be possibly associated with liver regenerative activity of SST. Genes targeted by microRNA were moreover associated with different biological pathways from the genes not targeted by microRNA. An analysis of promoter similarity indicated that co-expressed genes after SST treatment were clustered into subgroups, depending on the temporal expression patterns. We are the first to identify that SST regulates temporal gene expression by way of microRNA. MicroRNA targets and non-microRNA targets moreover have different biological roles. This functional segregation by microRNA would be critical for the elucidation of the molecular activities of SST.

Characterizing surface temperature and clarity of Kuwait's seawaters using remotely sensed measurements and GIS analyses

NASA Astrophysics Data System (ADS)

Alsahli, Mohammad M. M.

Kuwait sea surface temperature (SST) and water clarity are important water characteristics that influence the entire Kuwait coastal ecosystem. The spatial and temporal distributions of these important water characteristics should be well understood to obtain a better knowledge about this productive coastal environment. The aim of this project was therefore to study the spatial and temporal distributions of: Kuwait SST using Moderate Resolution Imaging Spectroradiometer (MODIS) images collected from January 2003 to July 2007; and Kuwait Secchi Disk Depth (SDD), a water clarity measure, using Sea-viewing Wide Field-of-view Sensor (SeaWiFS) and MODIS data collected from November 1998 to October 2004 and January 2003 to June 2007, respectively. Kuwait SST was modeled based on the linear relationship between level 2 MODIS SST data and in situ SST data. MODIS SST images showed a significant relationship with in situ SST data ( r2= 0.98, n = 118, RMSE = 0.7°C). Kuwait SST images derived from MODIS data exhibited three spatial patterns of Kuwait SST across the year that were mainly attributed to the northwestern counterclockwise water circulation of the Arabian Gulf, and wind direction and intensity. The temporal variation of Kuwait SST was greatly influenced by the seasonal variation of solar intensity and air temperatures. Kuwait SDD was measured through two steps: first, computing the diffuse light attenuation coefficient at 490 nm, Kd(490), and 488 nm, Kd(488), derived from SeaWiFS and MODIS, respectively, using a semi-analytical algorithm; second, establishing two SDD models based on the empirical relationship of Kd(490) and Kd(488) with in situ SDD data. Kd(490) and Kd(488) showed a significant relationship with in situ SDD data ( r2= 0.67 and r2= 0.68, respectively). Kuwait SDD images showed distinct spatial and temporal patterns of Kuwait water clarity that were mainly attributed to three factors: the Shatt Al-Arab discharge, water circulation, and coastal currents. The SeaWiFS and MODIS data compared to in situ measurements provided a comprehensive view of the studied seawater characteristics that improved their overall estimation within Kuwait's waters. Also, the near-real-time availability of SeaWiFS and MODIS data and their highly temporal resolution make them a very advantageous tool for studying coastal environments. Thus, I recommend involving this method in monitoring Kuwait coastal environments.

76 FR 4369 - Interim Deputation Agreements; Interim BIA Adult Detention Facility Guidelines

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-25

... Adult Detention Facility Guidelines AGENCY: Bureau of Indian Affairs, Interior. ACTION: Notice. SUMMARY: This notice announces the online publication of the Interim BIA Adult Detention Facility Guidelines and... Indian Affairs Web site. DATES: These Interim BIA Adult Detention Facility Guidelines and Interim Model...

Emerging role of Indian ocean on Indian northeast monsoon

NASA Astrophysics Data System (ADS)

Yadav, Ramesh Kumar

2013-07-01

This study examines the emerging role of Indian Ocean sea surface temperature (SST) on the inter-annual variability (IAV) of Indian north-east monsoon rainfall (NEMR). The IAV of NEMR is associated with the warm SST anomaly over east Bay-of-Bengal (BoB) (88.5oE-98.5oE; 8.5oN-15.5oN) and cool SST anomaly over east equatorial Indian Ocean (80.5oE-103.5oE; 6.5oS-3.5oN). The gradient of SST between these boxes (i.e. northern box minus southern box) shows strong and robust association with the Indian NEMR variability in the recent decades. For establishing the teleconnections, SST, mean sea level pressure, North Indian Ocean tropical storm track, and circulation data have been used. The study reveals that during the positive SST gradient years, the inter-tropical convergence zone (ITCZ) shifts northwards over the East Indian Ocean. The tropical depressions, storms and cyclones formed in the North Indian Ocean moves more zonally and strike the southern peninsular India and hence excess NEMR. While, during the negative SST gradient years, the ITCZ shifts southwards over the Indian Ocean. The tropical depressions, storms and cyclones formed in the North Indian Ocean moves more northwestward direction and after crossing 15oN latitude re-curve to north-east direction towards head BoB and misses southern peninsular India and hence, deficient NEMR.

Atmospheric Response to Zonal Variations in Midlatitude SST: Transient and Stationary Eddies and Their Feedback(.

NASA Astrophysics Data System (ADS)

Inatsu, Masaru; Mukougawa, Hitoshi; Xie, Shang-Ping

2003-10-01

Midwinter storm track response to zonal variations in midlatitude sea surface temperatures (SSTs) has been investigated using an atmospheric general circulation model under aquaplanet and perpetual-January conditions. Zonal wavenumber-1 SST variations with a meridionally confined structure are placed at various latitudes. Having these SST variations centered at 30°N leads to a zonally localized storm track, while the storm track becomes nearly zonally uniform when the same SST forcing is moved farther north at 40° and 50°N. Large (small) baroclinic energy conversion north of the warm (cold) SST anomaly near the axis of the storm track (near 40°N) is responsible for the large (small) storm growth. The equatorward transfer of eddy kinetic energy by the ageostrophic motion and the mechanical damping are important to diminish the storm track activity in the zonal direction.Significant stationary eddies form in the upper troposphere, with a ridge (trough) northeast of the warm (cold) SST anomaly at 30°N. Heat and vorticity budget analyses indicate that zonally localized condensational heating in the storm track is the major cause for these stationary eddies, which in turn exert a positive feedback to maintain the localized storm track by strengthening the vertical shear near the surface. These results indicate an active role of synoptic eddies in inducing deep, tropospheric-scale response to midlatitude SST variations. Finally, the application of the model results to the real atmosphere is discussed.

Analysis of purified glabra3-shapeshifter trichomes reveals a role for NOECK in regulating early trichome morphogenic events.

PubMed

Gilding, Edward K; Marks, M David

2010-10-01

Transcriptome analysis using the Affymetrix ATH1 platform has been completed on purified trichomes from the gl3-sst mutant. These trichomes display immature features, such as glassy cell walls and blunted branches. The gl3-sst trichome transcriptome was greatly enriched for genes involved in lipid biosynthesis, including those mediating the synthesis of fatty acids and wax. In addition, gl3-sst trichomes displayed reduced expression of the R3 MYBs TRY and CPC, which normally function to limit trichome development. The expression of the MIXTA-like MYB gene NOK was elevated. Members of the MIXTA-like family promote conical cell outgrowth, and in some cases, trichome initiation in diverse plant species. In contrast, NOK limits trichome outgrowth in wild-type Arabidopsis plants. Similar to other MIXTA-like genes, NOK was required for the expansion of gl3-sst trichomes, as the gl3-sst nok double mutant trichomes were greatly reduced in size. Expression of NOK in nok mutants reduced branch formation, whereas in gl3-sst nok, NOK expression promoted trichome cell outgrowth, illustrating duel roles for NOK in both promoting and limiting trichome development. MIXTA-like genes from phylogenetically diverse plant species could substitute for NOK in both nok and gl3-sst nok backgrounds. These findings suggest that certain aspects of NOK and MIXTA-like gene function have been conserved. © 2010 The Authors. Journal compilation © 2010 Blackwell Publishing Ltd.

Numerical Simulation of Atmospheric Response to Pacific Tropical Instability Waves(.

NASA Astrophysics Data System (ADS)

Small, R. Justin; Xie, Shang-Ping; Wang, Yuqing

2003-11-01

Tropical instability waves (TIWs) are 1000-km-long waves that appear along the sea surface temperature (SST) front of the equatorial cold tongue in the eastern Pacific. The study investigates the atmospheric planetary boundary layer (PBL) response to TIW-induced SST variations using a high-resolution regional climate model. An investigation is made of the importance of pressure gradients induced by changes in air temperature and moisture, and vertical mixing, which is parameterized in the model by a 1.5-level turbulence closure scheme. Significant turbulent flux anomalies of sensible and latent heat are caused by changes in the air sea temperature and moisture differences induced by the TIWs. Horizontal advection leads to the occurrence of the air temperature and moisture extrema downwind of the SST extrema. High and low hydrostatic surface pressures are then located downwind of the cold and warm SST patches, respectively. The maximum and minimum wind speeds occur in phase with SST, and a thermally direct circulation is created. The momentum budget indicates that pressure gradient, vertical mixing, and horizontal advection dominate. In the PBL the vertical mixing acts as a frictional drag on the pressure-gradient-driven winds. Over warm SST the mixed layer deepens relative to over cold SST. The model simulations of the phase and amplitude of wind velocity, wind convergence, and column-integrated water vapor perturbations due to TIWs are similar to those observed from satellite and in situ data.

Sea surface temperature measurements by the along-track scanning radiometer on the ERS 1 satellite: Early results

NASA Astrophysics Data System (ADS)

Mutlow, C. T.; ZáVody, A. M.; Barton, I. J.; Llewellyn-Jones, D. T.

1994-11-01

The along-track scanning radiometer (ATSR) was launched in July 1991 on the European Space Agency's first remote sensing satellite, ERS 1. An initial analysis of ATSR data demonstrates that the sea surface temperature (SST) can be measured from space with very high accuracy. Comparison of simultaneous measurements of SST made from ATSR and from a ship-borne radiometer show that they agree to within 0.3°C. To assess data consistency, a complementary analysis of SST data from ATSR was also carried out. The ATSR global SST field was compared on a daily basis with daily SST analysis of the United Kingdom Meteorological Office (UKMO). The ATSR global field is consistently within 1.0°C of the UKMO analysis. Also, to demonstrate the benefits of along-track scanning SST determination, the ATSR SST data were compared with high-quality bulk temperature observations from drifting buoys. The likely causes of the differences between ATSR and the bulk temperature data are briefly discussed. These results provide early confidence in the quantitative benefit of ATSR's two-angle view of the Earth and its high radiometric performance and show a significant advance on the data obtained from other spaceborne sensors. It should be noted that these measurements were made at a time when the atmosphere was severely contaminated with volcanic aerosol particles, which degrade infrared measurements of the Earth's surface made from space.

Sea Surface Temperature and Seawater Oxygen Isotope Variability Recorded in a Madagascar Coral Record

NASA Astrophysics Data System (ADS)

Zinke, J.; Dullo, W. Chr; Eisenhauer, A.

2003-04-01

We analysed a 336 year coral oxygen isotope record off southwest Madagascar in the Mozambique Channel. Based on temporal variability of skeletal oxygen isotopes annual mean sea surface temperatures are reconstructed for the period from 1659 to 1995. Sr/Ca ratios were measured for selected windows with monthly resolution (1973 to 1995, 1863 to 1910, 1784 to 1809, 1688 to 1710) to validate the SST reconstructions derived from oxygen isotopes. The coral proxy data were validated against gridded SST data sets. The coral oxygen isotope record is coherent with Kaplan-SST and GISST2.3b on an interdecadal frequency of 17 years, which is the most prominent frequency band observed in this region. The Sr/Ca-SST agree well with SST observations in the validation period (1863 to 1910), whereas the d18O derived SST show largest discrepencies during this time interval. By taking into account the SST values derived from coral Sr/Ca, we were able to reconstruct d18O seawater variability. This indicates that d18O seawater variations contributed significantly to interannual and interdecadal variations in coral d18O. We propose that the local surface-ocean evaporation-precipitation balance and remote forcing by ENSO via South Equatorial Current and/or Indonesian throughflow variability may contribute to observed d18O variability. Our results indicate that coral d18O may be used to reconstruct temporal variations in the fresh water balance within the Indian Ocean on interannual to interdecadal time scales.

24 CFR 35.820 - Interim controls.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Interim controls. 35.820 Section 35...-Possession Multifamily Property § 35.820 Interim controls. HUD shall conduct interim controls in accordance... accordance with § 35.815. Interim controls are considered completed when clearance is achieved in accordance...

24 CFR 35.820 - Interim controls.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Interim controls. 35.820 Section 35...-Possession Multifamily Property § 35.820 Interim controls. HUD shall conduct interim controls in accordance... accordance with § 35.815. Interim controls are considered completed when clearance is achieved in accordance...

The role of external forcing and Pacific trade winds in recent changes of the global climate system

NASA Astrophysics Data System (ADS)

Friedman, Andrew; Gastineau, Guillaume; Khodri, Myriam

2017-04-01

The Pacific trade winds experienced an unprecedented strengthening since the mid 1990s. Several studies have proposed that the increased Pacific trade winds were associated with the reduced rate of global mean surface temperature warming in the first decade of the 21st century, as well as far-reaching atmospheric teleconnections. We designed a set of ensemble partial coupling experiments using the IPSL-CM5A-LR coupled model that allow us to cleanly distinguish the influence of Pacific trade wind variability from that of external forcing over the past few decades. In this study, we quantify the respective impacts of these processes on surface temperature, ocean heat content, and atmospheric teleconnections. We designed two ensembles of coupled simulations using partial coupling with the IPSL-CM5A-LR model to separate the Pacific internal variability and that of external radiative forcing. We prescribe surface wind stress in the tropical Pacific (20°S to 20°N) from 1979-2014 in two ensembles of 30 members each: (1) Prescribed climatological model wind stress, which allows us to estimate the influence of external radiative forcing in the absence of variability within the Pacific Ocean. (2) Wind stress anomalies from ERA-Interim reanalysis added to the model wind stress climatology, which accounts for the effects of both external radiative forcing and the wind stress variability. We find that the observed wind stress anomalies account for the pattern of eastern tropical Pacific cooling when compared to the climatology experiment, so that it resembles the observed trends from 1992-2011. The tropical Pacific shows dominant heat uptake in the western Pacific above the 20°C isotherm, which contributed to slow the warming of tropical SST during the 2000s. The trade wind increase is associated with a strengthening of the Pacific Walker circulation, and zonal shifts in tropical rainfall. Despite tropical SST biases which affect the response of tropical rainfall and the location of deep convection, the wind stress anomaly forcing effectively simulates the wave train pattern emanating from the tropical Pacific, and associated extratropical teleconnections such as a weakening of the Aleutian Low and drought in North America.

Exploring the Links in Monthly to Decadal Variability of the Atmospheric Water Balance Over the Wettest Regions in ERA-20C

NASA Astrophysics Data System (ADS)

Nogueira, M.

2017-10-01

Monthly-to-decadal variability of the regional precipitation over Intertropical Convergence Zone and north-Atlantic and north-Pacific storm tracks was investigated using ERA-20C reanalysis. Satellite-based precipitation (P) and evaporation (E) climatological patterns were well reproduced by ERA-20C. Regional P and E monthly time series displayed 20% differences, but these decreased rapidly with time scale ( 10% at yearly time scales). Spectral analysis showed good scale-by-scale statistical agreement between ERA-20C and observations. Using ERA-Interim showed no improvement despite the much wider range of information assimilated (including satellites). Remarkably high Detrended Cross-Correlation Analysis coefficients (ρDCCA > 0.7 and often ρDCCA > 0.9) revealed tight links between the nonperiodic variability of P, moisture divergence (DIV), and pressure velocity (ω) at monthly-to-decadal time scales over all the wet regions. In contrast, ρDCCA was essentially nonsignificant between nonperiodic P and E or sea surface temperature (SST). Thus, the nonperiodic monthly-to-decadal variability of precipitation in these regions is almost fully controlled by dynamics and not by local E or SST (suggested by Clausius-Clapeyron relation). Analysis of regional nonperiodic standard deviations and power spectra (and respective spectral exponents, β) provided further robustness to this conclusion. Finally, clear transitions in β for P, DIV, and ω between tropical and storm track regions were found. The latter is dominated by transient storms, with energy accumulation at synoptic scales and β < 0.1 at monthly-to-decadal time scales, implying that variability and information creation decrease rapidly with time scale. Larger β values (0.2 to 0.4) were found in the tropics, implying longer-range autocorrelations and slower decreasing variability and information creation with time scale, consistent with the important forcing from internal modes of variability (e.g., El Niño-Southern Oscillation).

Seasonal Ice Zone Reconnaissance Surveys Coordination

DTIC Science & Technology

2014-09-30

profiler (AXCP) ocean velocity shear (Morison), UpTempO buoy measurements of sea surface temperature (SST), sea level atmospheric pressure ( SLP ), and...and prediction…. Steele UpTempO buoy drops for SLP , SST, SSS, & surface velocity Visible and Thermal Images of the SIZ from the Coast Guard...Expendable CTD, AXCP= Air Expendable Current Profiler, SLP = Sea Level atmospheric Pressure, SST= Seas Surface Temperature, A/C= aircraft, SIC=Sea Ice

Sea surface temperature variability in the Gulf of Mexico from 1734-2008 CE: A reconstruction using cross-dated Sr/Ca records from the coral Siderastrea siderea

NASA Astrophysics Data System (ADS)

DeLong, K. L.; Flannery, J. A.; Quinn, T. M.; Maupin, C. R.; Lin, K.; Shen, C.

2013-12-01

Sea surface temperature (SST) variability in the Gulf of Mexico impacts climate in Central and North America because the Gulf is a major source of moisture and is a source region for the Gulf Stream, which transports ocean heat northward. Here we use skeletal variations in coral Sr/Ca from three Siderastrea siderea coral colonies within the Dry Tortugas National Park in the southeastern Gulf of Mexico (24°42'N, 82°48'W) to develop 274 years of monthly-resolved SST variations. The cross-dated chronology, determined by counting annual density bands and correlating Sr/Ca variations, is verified by four replicated high precision 230Th dates (×1.7-37 years, 2σ). Calibration and verification of our replicated coral Sr/Ca-SST reconstruction with Dry Tortugas SST (r = 0.98 and 0.55 for monthly and 36-month smoothed, respectively; 1992-2008 CE) and Key West, Florida surface air temperature (1895-2008 CE) measurements reveals similar covariance (r = 0.96 and 0.56 for monthly and 36-month smoothed, respectively). The absolute coral SST reconstruction is consistent with SST recorded at the Dry Tortugas lighthouse from 1879-1907 CE indicating that this coral Sr/Ca-SST relationship is stable on centennial time scales. The Sr/Ca-SST reconstruction reveals ~2.0°C interannual variability, ~1.5°C decadal fluctuations, and a 0.7°C warming trend for the past 274 years. Secular variability in our reconstruction is similar to approximately decadally resolved planktic foraminifer Mg/Ca records from the northern Gulf of Mexico. The coral Sr/Ca-SST reconstruction reveals colder decades (~1.5°C) suggesting a reduction in moisture and ocean heat flux from the Gulf of Mexico. We find winter extremes are more variable than summer extremes (×2.2°C vs. ×1.6°C, 2σ) with a stronger warming trend (1°C) in the summers suggesting continued warming may increase coral bleaching.

A reconstruction of sea surface temperature variability in the southeastern Gulf of Mexico from 1734 to 2008 C.E. using cross-dated Sr/Ca records from the coral Siderastrea siderea

USGS Publications Warehouse

DeLong, Kristine L.; Maupin, Christopher R.; Flannery, Jennifer A.; Quinn, Terrence M.; Shen, CC

2014-01-01

This study uses skeletal variations in coral Sr/Ca from three Siderastrea siderea coral colonies within the Dry Tortugas National Park in the southeastern Gulf of Mexico (24°42′N, 82°48′W) to reconstruct monthly sea surface temperature (SST) variations from 1734 to 2008 Common Era (C.E.). Calibration and verification of the replicated coral Sr/Ca-SST reconstruction with local, regional, and historical temperature records reveals that this proxy-temperature relationship is stable back to 1879 C.E. The coral SST reconstruction contains robust interannual (~2.0°C) and multidecadal variability (~1.5°C) for the past 274 years, the latter of which does not covary with the Atlantic Multidecadal Oscillation. Winter SST extremes are more variable than summer SST extremes (±2.2°C versus ±1.6°C, 2σ) suggesting that Loop Current transport in the winter dominates variability on interannual and longer time scales. Summer SST maxima are increasing (+1.0°C for 274 years, σMC = ±0.5°C, 2σ), whereas winter SST minima contain no significant trend. Colder decades (~1.5°C) during the Little Ice Age (LIA) do not coincide with decades of sunspot minima. The coral SST reconstruction contains similar variability to temperature reconstructions from the northern Gulf of Mexico (planktic foraminifer Mg/Ca) and the Caribbean Sea (coral Sr/Ca) suggesting areal reductions in the Western Hemisphere Warm Pool during the LIA. Mean summer coral SST extremes post-1985 C.E. (29.9°C) exceeds the long-term summer average (29.2°C for 1734–2008 C.E.), yet the warming trend after 1985 C.E. (0.04°C for 24 years, σMC = ±0.5, 2σ) is not significant, whereas Caribbean coral Sr/Ca studies contain a warming trend for this interval.

The relative importance of ENSO and tropical Atlantic sea surface temperature anomalies for seasonal precipitation over South America: a numerical study

NASA Astrophysics Data System (ADS)

Pezzi, L. P.; Cavalcanti, I. F. A.

The role of tropical Atlantic sea surface temperature (SST) anomalies during ENSO episodes over northeast Brazil (Nordeste) is investigated using the CPTEC/COLA Atmospheric General Circulation Model (AGCM). Four sets of integrations are performed using SST in El Niño and La Niña (ENSO) episodes, changing the SST of the Atlantic Ocean. A positive dipole (SST higher than normal in the tropical North Atlantic and below normal in the tropical South Atlantic) and a negative dipole (opposite conditions), are set as the boundary conditions of SST in the Atlantic Ocean. The four experiments are performed using El Niño or La Niña SST in all oceans, except in the tropical Atlantic where the two phases of the SST dipole are applied. Five initial conditions were integrated in each case in order to obtain four ensemble results. The positive SST dipole over the tropical Atlantic Ocean and El Niño conditions over the Pacific Ocean resulted in dry conditions over the Nordeste. When the negative dipole and El Niño conditions over the Pacific Ocean were applied, the results showed precipitation above normal over the north of Nordeste. When La Niña conditions over Pacific Ocean were tested together with a negative dipole, positive precipitation anomalies occurred over the whole Nordeste. Using the positive dipole over the tropical Atlantic, the precipitation over Nordeste was below average. During La Niña episodes, the Atlantic Ocean conditions have a larger effect on the precipitation of Nordeste than the Pacific Ocean. In El Niño conditions, only the north region of Nordeste is affected by the Atlantic SST. Other tropical areas of South America show a change only in the intensity of anomalies. Central and southeast regions of South America are affected by the Atlantic conditions only during La Niña conditions, whereas during El Niño these regions are influenced only by conditions in the Pacific Ocean.

Sea Surface Temperatures in the Indo-Pacific Warm Pool During the Early Pliocene Warm Period

NASA Astrophysics Data System (ADS)

Dekens, P. S.; Ravelo, A. C.; Griffith, E. M.

2010-12-01

The Indo-Pacific warm pool (IPWP) plays an important role in both regional and global climate, but the response of this region to anthropogenic climate change is not well understood. While the early Pliocene is not a perfect analogue for anthropogenic climate change, it is the most recent time in Earth history when global temperatures were warmer than they are today for a sustained period of time. SST in the eastern equatorial Pacific was 2-4○C warmer in the early Pliocene compared to today. A Mg/Ca SST at ODP site 806 in the western equatorial Pacific indicates that SST were stable through the last 5Ma (Wara et al., 2005). We generated a G. sacculifer Mg/Ca record in the Indian Ocean (ODP sit 758) for the last 5 Ma, which also shows that IPWP SST has remained relatively stable through the last 5 Ma and was not warmer in the early Pliocene compared today. A recent paper suggests that the Mg/Ca of seawater may have varied through the last 5 Ma and significantly affected Mg/Ca SST estimates (Medina-Elizalde et al., 2008). However, there is considerable uncertainty in the estimates of seawater Mg/Ca variations through time. We will present a detailed examination of these uncertainties to examine the possible range of seawater Mg/Ca through the last 5 Ma. Due to the lack of culturing work of foraminifera at different Mg/Ca ratios in the growth water there is also uncertainty in how changes in seawater Mg/Ca will affect the temperatures signal in the proxy. We will explore how uncertainties in the record of seawater Mg/Ca variations through time and its effect on the Mg/Ca SST proxy potentially influence the interpretation of the Mg/Ca SST records at ODP sites 806 and 758 in the IPWP, and ODP site 847 in the eastern equatorial Pacific. We will also explore how adjustment of the Mg/Ca SST estimates (due to reconstructed Mg/Ca seawater variations) affects the δ18O of water when adjusted Mg/Ca SST estimates are paired with δ18O measurements of the same samples.

Global Sea Surface Temperature: A Harmonized Multi-sensor Time-series from Satellite Observations

NASA Astrophysics Data System (ADS)

Merchant, C. J.

2017-12-01

This paper presents the methods used to obtain a new global sea surface temperature (SST) dataset spanning the early 1980s to the present, intended for use as a climate data record (CDR). The dataset provides skin SST (the fundamental measurement) and an estimate of the daily mean SST at depths compatible with drifting buoys (adjusting for skin and diurnal variability). The depth SST provided enables the CDR to be used with in situ records and centennial-scale SST reconstructions. The new SST timeseries is as independent as possible from in situ observations, and from 1995 onwards is harmonized to an independent satellite reference (namely, SSTs from the Advanced Along Track Scanning Radiometer (Advanced ATSR)). This maximizes the utility of our new estimates of variability and long-term trends in interrogating previous datasets tied to in situ observations. The new SSTs include full resolution (swath, level 2) data, single-sensor gridded data (level 3, 0.05 degree latitude-longitude grid) and a multi-sensor optimal analysis (level 4, same grid). All product levels are consistent. All SSTs have validated uncertainty estimates attached. The sensors used include all Advanced Very High Resolution Radiometers from NOAA-6 onwards and the ATSR series. AVHRR brightness temperatures (BTs) are calculated from counts using a new in-flight re-calibration for each sensor, ultimately linked through to the AATSR BT calibration by a new harmonization technique. Artefacts in AVHRR BTs linked to varying instrument temperature, orbital regime and solar contamination are significantly reduced. These improvements in the AVHRR BTs (level 1) translate into improved cloud detection and SST (level 2). For cloud detection, we use a Bayesian approach for all sensors. For the ATSRs, SSTs are derived with sufficient accuracy and sensitivity using dual-view coefficients. This is not the case for single-view AVHRR observations, for which a physically based retrieval is employed, using a hybrid maximum a posteriori / maximum likelihood retrieval, which optimises retrieval uncertainty and SST sensitivity for climate applications. Validation results will be presented along with examples of the variability and trends in SST evident in the dataset.

The components of somatostatin and ghrelin systems are altered in neuroendocrine lung carcinoids and associated to clinical-histological features.

PubMed

Herrera-Martínez, Aura D; Gahete, Manuel D; Sánchez-Sánchez, Rafael; Salas, Rosa Ortega; Serrano-Blanch, Raquel; Salvatierra, Ángel; Hofland, Leo J; Luque, Raúl M; Gálvez-Moreno, María A; Castaño, Justo P

2017-07-01

Lung carcinoids (LCs) are rare tumors that comprise 1-5% of lung malignancies but represent 20-30% of neuroendocrine tumors. Their incidence is progressively increasing and a better characterization of these tumors is required. Alterations in somatostatin (SST)/cortistatin (CORT) and ghrelin systems have been associated to development/progression of various endocrine-related cancers, wherein they may become useful diagnostic, prognostic and therapeutic biomarkers. We aimed to evaluate the expression levels of ghrelin and SST/CORT system components in LCs, as well as to explore their putative relationship with histological/clinical characteristics. An observational retrospective study was performed; 75 LC patients with clinical/histological characteristics were included. Samples from 46 patients were processed to isolate mRNA from tumor and adjacent non-tumor region, and the expression levels of SST/CORT and ghrelin systems components, determined by quantitative-PCR, were compared to those of 7 normal lung tissues. Patient cohort was characterized by mean age 53±15 years, 48% males, 34% with tobacco exposure; 71.4/28.6% typical/atypical carcinoids, 21.7% incidental tumors, 4.3% functioning tumors, 17.7% with metastasis. SST/CORT and ghrelin system components were expressed at variable levels in a high proportion of tumors, as well as in adjacent non-tumor tissues, while a lower proportion of normal lung samples also expressed these molecules. A gradation was observed from normal non-neoplastic lung tissues, non-tumor adjacent tissue and LCs, being SST, sst4, sst5, GHS-R1a and GHS-R1b overexpressed in tumor tissue compared to normal tissue. Importantly, several SST/CORT and ghrelin system components displayed significant correlations with relevant clinical parameters, such as necrosis, peritumoral and vascular invasion, or metastasis. Altogether, these data reveal a prominent, widespread expression of key SST/CORT/ghrelin system components in LCs, where they display clinical-histological correlations, which could provide novel, valuable markers for NET patient management. Copyright © 2017 Elsevier B.V. All rights reserved.

Remote sensing measurements of sea surface temperature as an indicator of Vibrio parahaemolyticus in oyster meat and human illnesses.

PubMed

Konrad, Stephanie; Paduraru, Peggy; Romero-Barrios, Pablo; Henderson, Sarah B; Galanis, Eleni

2017-08-31

Vibrio parahaemolyticus (Vp) is a naturally occurring bacterium found in marine environments worldwide. It can cause gastrointestinal illness in humans, primarily through raw oyster consumption. Water temperatures, and potentially other environmental factors, play an important role in the growth and proliferation of Vp in the environment. Quantifying the relationships between environmental variables and indicators or incidence of Vp illness is valuable for public health surveillance to inform and enable suitable preventative measures. This study aimed to assess the relationship between environmental parameters and Vp in British Columbia (BC), Canada. The study used Vp counts in oyster meat from 2002-2015 and laboratory confirmed Vp illnesses from 2011-2015 for the province of BC. The data were matched to environmental parameters from publicly available sources, including remote sensing measurements of nighttime sea surface temperature (SST) obtained from satellite readings at a spatial resolution of 1 km. Using three separate models, this paper assessed the relationship between (1) daily SST and Vp counts in oyster meat, (2) weekly mean Vp counts in oysters and weekly Vp illnesses, and (3) weekly mean SST and weekly Vp illnesses. The effects of salinity and chlorophyll a were also evaluated. Linear regression was used to quantify the relationship between SST and Vp, and piecewise regression was used to identify SST thresholds of concern. A total of 2327 oyster samples and 293 laboratory confirmed illnesses were included. In model 1, both SST and salinity were significant predictors of log(Vp) counts in oyster meat. In model 2, the mean log(Vp) count in oyster meat was a significant predictor of Vp illnesses. In model 3, weekly mean SST was a significant predictor of weekly Vp illnesses. The piecewise regression models identified a SST threshold of approximately 14 o C for both model 1 and 3, indicating increased risk of Vp in oyster meat and Vp illnesses at higher temperatures. Monitoring of SST, particularly through readily accessible remote sensing data, could serve as a warning signal for Vp and help inform the introduction and cessation of preventative or control measures.

75 FR 984 - Draft Recommended Interim Preliminary Remediation Goals for Dioxin in Soil at CERCLA and RCRA Sites

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-07

... Recommended Interim Preliminary Remediation Goals for Dioxin in Soil at CERCLA and RCRA Sites AGENCY... Recommended Interim Preliminary Remediation Goals for Dioxin in Soil at Comprehensive Environmental Response... interim PRGs for dioxin in soil. These draft recommended interim PRGs were calculated using existing, peer...

Mental health pharmacists as interim prescribers

PubMed Central

2017-01-01

Introduction: Turnover leading to fluctuations in prescriber availability presents many challenges, most notably in access to and continuity of care. In 2015, the Veterans Affairs Eastern Colorado Healthcare System (VA ECHCS) experienced a period of significant mental health prescriber turnover leading to patient utilization of psychiatric emergency services (PES) for nonemergent medication management. The resulting increase in volume placed excessive stress on PES prescribers. Mental health pharmacists have opportunities to provide interim medication management while patients are between prescribers. Methods: This study was a retrospective, cohort study of patients unassigned to an outpatient mental health prescriber due to prescriber turnover, receiving care at VA ECHCS between October 1, 2015, and February 28, 2016. The primary outcome was the number of pharmacist interventions performed. Secondary outcomes characterize the interventions performed and describe the change in the mean monthly volume of patients presenting to PES. Results: In this veteran population, 152 interventions were performed in 81 unique patients. The most common intervention was prescription renewals (80%). Interventions most commonly involved antidepressants (28%), antipsychotics (10%), and mood stabilizers (10%). Before initiation of the clinic, Denver VA PES experienced a mean of 300 monthly visits. After clinic implementation, PES visits decreased significantly to a mean of 237 visits per month (P = .041). Discussion: The pharmacist interim prescriber clinic was associated with a significant decrease in mean number of patients seen per month in PES. The success of the clinic also contributed to interest by the mental health service to expand clinical pharmacy services.

Radiological characterization of skyshine from a retired, low-level, radioactive liquid effluent disposal facility at Hanford

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, R.C.; Perkins, C.J.

1991-02-01

The 1301-N Liquid Waste Disposal Facility, located on the Hanford Site received N Reactor low-level radioactive liquid process effluent from 1962 to 1985. Radiation emanating from the top of the trench sections was not significant because of the sediments were normally under several meters of water, which provided the necessary shielding. Following retirement of the facility, the liquid in the trench sections percolated into the ground leaving the residual radioactively contaminated sediments unshielded along the bottom and sides of the trench sections. The radioactive constituents of the contaminated sediments include the gamma-emitting isotopes Co-60 and Cs-137. Because of the lackmore » of water covering, some of the gamma photons that were emitted upward were scattered downward due to Compton interaction with atmospheric constituents. This phenomenon is known as skyshine.'' A radiological characterization was required to provide guidance for determining the effectiveness of interim stabilization alternatives that would not adversely affect future Resource Conservation and Recovery Act site closure activities, (e.g., filling in trench sections with spoils from excavation activities). A noninvasive radiological characterization of this disposal facility and the affected area of the Columbia River shoreline was conducted. This characterization confirmed that skyshine is the cause of the elevated shoreline exposure rates and provided a model that could be used to rate the effectiveness of alternative interim stabilization measures. 4 refs., 5 figs.« less

Synchronous multi-decadal climate variability of the whole Pacific areas revealed in tree rings since 1567

NASA Astrophysics Data System (ADS)

Fang, Keyan; Cook, Edward; Guo, Zhengtang; Chen, Deliang; Ou, Tinghai; Zhao, Yan

2018-02-01

Oceanic and atmospheric patterns play a crucial role in modulating climate variability from interannual to multi-decadal timescales by causing large-scale co-varying climate changes. The brevity of the existing instrumental records hinders the ability to recognize climate patterns before the industrial era, which can be alleviated using proxies. Unfortunately, proxy based reconstructions of oceanic and atmospheric modes of the past millennia often have modest agreements with each other before the instrumental period, raising questions about the robustness of the reconstructions. To ensure the stability of climate signals in proxy data through time, we first identified tree-ring datasets from distant regions containing coherent variations in Asia and North America, and then interpreted their climate information. We found that the multi-decadal covarying climate patterns of the middle and high latitudinal regions around the northern Pacific Ocean agreed quite well with the climate reconstructions of the tropical and southern Pacific areas. This indicates a synchronous variability at the multi-decadal timescale of the past 430 years for the entire Pacific Ocean. This pattern is closely linked to the dominant mode of the Pacific sea surface temperature (SST) after removing the warming trend. This Pacific multi-decadal SST variability resembles the Interdecadal Pacific Oscillation.

Contracts, grants and funding summary of supersonic cruise research and variable-cycle engine technology programs, 1972 - 1982

NASA Technical Reports Server (NTRS)

Hoffman, S.; Varholic, M. C.

1983-01-01

NASA-SCAR (AST) program was initiated in 1972 at the direct request of the Executive Office of the White House and Congress following termination of the U.S. SST program. The purpose of SCR was to conduct a focused research and technology program on those technology programs which contributed to the SST termination and, also, to provide an expanded data base for future civil and military supersonic transport aircraft. Funding for the Supersonic Cruise Research (SCR) Program was initiated in fiscal year 1973 and terminated in fiscal year 1981. The program was implemented through contracts and grants with industry, universities, and by in-house investigations at the NASA/OAST centers. The studies included system studies and five disciplines: propulsion, stratospheric emissions impact, materials and structures, aerodynamic performance, and stability and control. The NASA/Lewis Variable-Cycle Engine (VCE) Component Program was initiated in 1976 to augment the SCR program in the area of propulsion. After about 2 years, the title was changed to VCE Technology program. The total number of contractors and grantees on record at the AST office in 1982 was 101 for SCR and 4 for VCE. This paper presents a compilation of all the contracts and grants as well as the funding summaries for both programs.

Bifurcation analysis of delay-induced resonances of the El-Niño Southern Oscillation

PubMed Central

Krauskopf, Bernd; Sieber, Jan

2014-01-01

Models of global climate phenomena of low to intermediate complexity are very useful for providing an understanding at a conceptual level. An important aspect of such models is the presence of a number of feedback loops that feature considerable delay times, usually due to the time it takes to transport energy (for example, in the form of hot/cold air or water) around the globe. In this paper, we demonstrate how one can perform a bifurcation analysis of the behaviour of a periodically forced system with delay in dependence on key parameters. As an example, we consider the El-Niño Southern Oscillation (ENSO), which is a sea-surface temperature (SST) oscillation on a multi-year scale in the basin of the Pacific Ocean. One can think of ENSO as being generated by an interplay between two feedback effects, one positive and one negative, which act only after some delay that is determined by the speed of transport of SST anomalies across the Pacific. We perform here a case study of a simple delayed-feedback oscillator model for ENSO, which is parametrically forced by annual variation. More specifically, we use numerical bifurcation analysis tools to explore directly regions of delay-induced resonances and other stability boundaries in this delay-differential equation model for ENSO. PMID:25197254

On the Use of Ocean Dynamic Temperature for Hurricane Intensity Forecasting

DOE Office of Scientific and Technical Information (OSTI.GOV)

Balaguru, Karthik; Foltz, Gregory R.; Leung, L. Ruby

Sea surface temperature (SST) and the Tropical Cyclone Heat Potential (TCHP) are metrics used to incorporate the ocean's influence on hurricane intensification in the National Hurricane Center's Statistical Hurricane Intensity Prediction Scheme (SHIPS). While both SST and TCHP serve as useful measures of the upper-ocean heat content, they do not accurately represent ocean stratification effects. Here we show that replacing SST in the SHIPS framework with a dynamic temperature (Tdy), which accounts for the oceanic negative feedback to the hurricane's intensity arising from storm-induced vertical mixing and sea-surface cooling, improves the model performance. While the model with SST and TCHPmore » explains nearly 41% of the variance in 36-hr intensity changes, replacing SST with Tdy increases the variance explained to nearly 44%. Our results suggest that representation of the oceanic feedback, even through relatively simple formulations such as Tdy, may improve the performance of statistical hurricane intensity prediction models such as SHIPS.« less

Sea surface temperature 1871-2099 in 38 cells in the Caribbean region.

PubMed

Sheppard, Charles; Rioja-Nieto, Rodolfo

2005-09-01

Sea surface temperature (SST) data with monthly resolution are provided for 38 cells in the Caribbean Sea and Bahamas region, plus Bermuda. These series are derived from the HadISST1 data set for historical time (1871-1999) and from the HadCM3 coupled climate model for predicted SST (1950-2099). Statistical scaling of the forecast data sets are performed to produce confluent SST series according to a now established method. These SST series are available for download. High water temperatures in 1998 killed enormous amounts of corals in tropical seas, though in the Caribbean region the effects at that time appeared less marked than in the Indo-Pacific. However, SSTs are rising in accordance with world-wide trends and it has been predicted that temperature will become increasingly important in this region in the near future. Patterns of SST rise within the Caribbean region are shown, and the importance of sub-regional patterns within this biologically highly interconnected area are noted.

An equilibrium model for the coupled ocean-atmosphere boundary layer in the tropics

NASA Technical Reports Server (NTRS)

Sui, C.-H.; Lau, K.-M.; Betts, Alan K.

1991-01-01

An atmospheric convective boundary layer (CBL) model is coupled to an ocean mixed-layer (OML) model in order to study the equilibrium state of the coupled system in the tropics, particularly in the Pacific region. The equilibrium state of the coupled system is solved as a function of sea-surface temperature (SST) for a given surface wind and as a function of surface wind for a given SST. It is noted that in both cases, the depth of the CBL and OML increases and the upwelling below the OML decreases, corresponding to either increasing SST or increasing surface wind. The coupled ocean-atmosphere model is solved iteratively as a function of surface wind for a fixed upwelling and a fixed OML depth, and it is observed that SST falls with increasing wind in both cases. Realistic gradients of mixed-layer depth and upwelling are observed in experiments with surface wind and SST prescribed as a function of longitude.

A Comparison Between SST and AOT Derived from AVHRR and MODIS Data in the Frame of the CREPAD Program

NASA Astrophysics Data System (ADS)

Robles-Gonzalez, Cristina; Fernandez-Renau, Alix; Lopez Gordillo, Noelia; Sevilla, Angel Garcia; Suarez, Juana Santana

2010-12-01

Since 1997, the INTA-CREPAD (Centre for REception, Processing, Archiving and Dissemination of Earth Observation Data) program distributes freely some of the most demanded low-resolution remote sensing products: SST, Ocean Chl-a, NDVI, AOD... The data input for such products are captured at the Canary Space Station (Centro Espacial de Canarias, CEC). The data sensors received at the station and used in the CREPAD program are AVHRR, SEAWIFS and MODIS. In this study SST and AOD retrieved by CREPAD algorithms from AVHRR and the SEADAS derived SST and AOD from MODIS have compared. SST values agree very well within 0.1±0.5oC and the coefficient of correlation of the images is 0.9. AOD validation gives good results taking into account the differences in the algorithms used. Mean AOD difference at 0.630 μm is 0.01±0.05 and the correlation coefficient is 0.6.

Investigating the dominant corrections to the strong-stretching theory for dry polymeric brushes.

PubMed

Matsen, M W

2004-07-22

The accuracy of strong-stretching theory (SST) is examined against a detailed comparison to self-consistent field theory (SCFT) on dry polymeric brushes with thicknesses of up to approximately 17 times the natural chain extension. The comparison provides the strongest evidence to date that SST represents the exact thick-brush limit of SCFT. More importantly, it allows us to assess the effectiveness of proposed finite-stretching corrections to SST. Including the entropy of the free ends is shown to rectify the most severe inaccuracies in SST. The proximal layer proposed by Likhtman and Semenov provides another significant improvement, and we identify one further effect of similar importance for which there is not yet an accurate treatment. Furthermore, our study provides a valuable means of rejecting mistaken refinements to SST, and indeed one such example is revealed. A proper treatment of finite-stretching corrections is vital to a wide range of phenomena that depend on a small excess free energy, such as autophobic dewetting and the interaction between opposing brushes.

On the persistence and coherence of subpolar sea surface temperature and salinity anomalies associated with the Atlantic multidecadal variability

NASA Astrophysics Data System (ADS)

Zhang, Rong

2017-08-01

This study identifies key features associated with the Atlantic multidecadal variability (AMV) in both observations and a fully coupled climate model, e.g., decadal persistence of monthly mean subpolar North Atlantic (NA) sea surface temperature (SST) and salinity (SSS) anomalies, and high coherence at low frequency among subpolar NA SST/SSS, upper ocean heat/salt content, and the Atlantic Meridional Overturning Circulation (AMOC) fingerprint. These key AMV features, which can be used to distinguish the AMV mechanism, cannot be explained by the slab ocean model results or the red noise process but are consistent with the ocean dynamics mechanism. This study also shows that at low frequency, the correlation and regression between net surface heat flux and SST anomalies are key indicators of the relative roles of oceanic versus atmospheric forcing in SST anomalies. The oceanic forcing plays a dominant role in the subpolar NA SST anomalies associated with the AMV.

Merging daily sea surface temperature data from multiple satellites using a Bayesian maximum entropy method

NASA Astrophysics Data System (ADS)

Tang, Shaolei; Yang, Xiaofeng; Dong, Di; Li, Ziwei

2015-12-01

Sea surface temperature (SST) is an important variable for understanding interactions between the ocean and the atmosphere. SST fusion is crucial for acquiring SST products of high spatial resolution and coverage. This study introduces a Bayesian maximum entropy (BME) method for blending daily SSTs from multiple satellite sensors. A new spatiotemporal covariance model of an SST field is built to integrate not only single-day SSTs but also time-adjacent SSTs. In addition, AVHRR 30-year SST climatology data are introduced as soft data at the estimation points to improve the accuracy of blended results within the BME framework. The merged SSTs, with a spatial resolution of 4 km and a temporal resolution of 24 hours, are produced in the Western Pacific Ocean region to demonstrate and evaluate the proposed methodology. Comparisons with in situ drifting buoy observations show that the merged SSTs are accurate and the bias and root-mean-square errors for the comparison are 0.15°C and 0.72°C, respectively.

Mean gravity anomalies from a combination of Apollo/ATS 6 and GEOS 3/ATS 6 SST tracking campaigns. [Satellite to Satellite Tracking

NASA Technical Reports Server (NTRS)

Kahn, W. D.; Klosko, S. M.; Wells, W. T.

1982-01-01

Advances in satellite tracking data accuracy and coverage over the past 15 years have led to major improvements in global geopotential models. But the spacial resolution of the gravity field obtained solely from satellite dynamics sensed by tracking data is still of the order of 1000 km. Attention is given to an approach which will provide information regarding the fine structure of the gravity field on the basis of an application of local corrections to the global field. According to this approach, a basic satellite to satellite tracked (SST) range-rate measurement is constructed from the link between a ground station, a geosynchronous satellite (ATS 6), and a near-earth satellite (Apollo or GEOS 3). Attention is given to a mathematical model, the simulation of SST gravity anomaly estimation accuracies, a gravity anomaly estimation from GEOS 3/ATS 6 and Apollo/ATS 6 SST observations, and an evaluation of the mean gravity anomalies determined from SST.

Reexamination of the relation between depth of the Antarctic ozone hole, and equatorial QBO and SST, 1962-1992

DOE Office of Scientific and Technical Information (OSTI.GOV)

Angell, J.K.

1993-08-06

This paper reports on an examination of previous data to see if a correlation can be found between the average depth of the Antarctic ozone hole, and the equatorial quasi-biennial oscillation (QBO) and/or sea surface temperature (SST). Data from the period 1962 to 1992 is examined. The only ozone data which spans this period is the Dobson total ozone data from the South Pole. The data considered is the average from mid October through November. The 50 mb zonal wind at Singapore is taken as a measure of the QBO. The average SST in the region 12S - 2N, 180Wmore » - 90W, the El Nino region, is taken for the SST value. The objective of this correlation is for predictive purposes. There is a weak correlation to the QBO, and a much weaker correlation to the SST from this data set.« less

The absence of an Atlantic imprint on the multidecadal variability of wintertime European temperature

PubMed Central

Yamamoto, Ayako; Palter, Jaime B.

2016-01-01

Northern Hemisphere climate responds sensitively to multidecadal variability in North Atlantic sea surface temperature (SST). It is therefore surprising that an imprint of such variability is conspicuously absent in wintertime western European temperature, despite that Europe's climate is strongly influenced by its neighbouring ocean, where multidecadal variability in basin-average SST persists in all seasons. Here we trace the cause of this missing imprint to a dynamic anomaly of the atmospheric circulation that masks its thermodynamic response to SST anomalies. Specifically, differences in the pathways Lagrangian particles take to Europe during anomalous SST winters suppress the expected fluctuations in air–sea heat exchange accumulated along those trajectories. Because decadal variability in North Atlantic-average SST may be driven partly by the Atlantic Meridional Overturning Circulation (AMOC), the atmosphere's dynamical adjustment to this mode of variability may have important implications for the European wintertime temperature response to a projected twenty-first century AMOC decline. PMID:26975331

Seasonal Ice Zone Reconnaissance Surveys Coordination and Ocean Profiles

DTIC Science & Technology

2015-09-30

Morison), UpTempO buoy measurements of sea surface temperature (SST), sea level atmospheric pressure ( SLP ), and velocity (Steele), and dropsonde...dropsondes, micro-aircraft), cloud top/base heights UpTempO buoys for understanding and prediction…. Steele UpTempO buoy drops for SLP , SST, SSS...Air Expendable Current Profiler, SLP = Sea Level atmospheric Pressure, SST= Seas Surface Temperature, A/C= aircraft, SIC=Sea Ice Concentration We

Predictive value of serum sST2 in preschool wheezers for development of asthma with high FeNO.

PubMed

Ketelaar, M E; van de Kant, K D; Dijk, F N; Klaassen, E M; Grotenboer, N S; Nawijn, M C; Dompeling, E; Koppelman, G H

2017-11-01

Wheezing is common in childhood. However, current prediction models of pediatric asthma have only modest accuracy. Novel biomarkers and definition of subphenotypes may improve asthma prediction. Interleukin-1-receptor-like-1 (IL1RL1 or ST2) is a well-replicated asthma gene and associates with eosinophilia. We investigated whether serum sST2 predicts asthma and asthma with elevated exhaled NO (FeNO), compared to the commonly used Asthma Prediction Index (API). Using logistic regression modeling, we found that serum sST2 levels in 2-3 years-old wheezers do not predict doctors' diagnosed asthma at age 6 years. Instead, sST2 predicts a subphenotype of asthma characterized by increased levels of FeNO, a marker for eosinophilic airway inflammation. Herein, sST2 improved the predictive value of the API (AUC=0.70, 95% CI 0.56-0.84), but had also significant predictive value on its own (AUC=0.65, 95% CI 0.52-0.79). Our study indicates that sST2 in preschool wheezers has predictive value for the development of eosinophilic airway inflammation in asthmatic children at school age. © 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

Effect of ENSO on the variability of SST and Chlorophyll-a in Java Sea

NASA Astrophysics Data System (ADS)

Wirasatriya, Anindya; Prasetyawan, Indra B.; Triyono, Chandra D.; Muslim; Maslukah, Lilik

2018-02-01

Sea surface temperature (SST) and chlorophyll-a (Chl-a) are two parameters often used for identifying the marine productivity. Located at the maritime continent, the variability of SST and Chl-a in the Indonesian seas is influenced by El Niño Southern Oscillation (ENSO). The previous studies showed that the effect of El Niño tend to decrease SST and increase Chl-a in the areas within the Indonesian seas. Using long time observation of satellite data (2003-2016), it was found different result in Java Sea. Since Java Sea has strong seasonal variability influenced by monsoon wind, the effect of ENSO depend on the season. During southeast monsoon season, El Niño (La Niña) tend to increase (decrease) the speed of southeasterly wind cause the decrease or increase of SST. On the contrary, during northwest monsoon season, El Niño (La Niña) tend to decrease (increase) the speed of northwesterly wind cause the increase (decrease) of SST. The dependence of Chl-a on wind speed is only observed in the off shore which exhibit the strong seasonal variation. However, the effect of ENSO on the variability of Chl-a is not robust since the effected amplitude is less than the RMSE of Chl-a data.

Eocene greenhouse climate revealed by coupled clumped isotope-Mg/Ca thermometry.

PubMed

Evans, David; Sagoo, Navjit; Renema, Willem; Cotton, Laura J; Müller, Wolfgang; Todd, Jonathan A; Saraswati, Pratul Kumar; Stassen, Peter; Ziegler, Martin; Pearson, Paul N; Valdes, Paul J; Affek, Hagit P

2018-02-06

Past greenhouse periods with elevated atmospheric CO 2 were characterized by globally warmer sea-surface temperatures (SST). However, the extent to which the high latitudes warmed to a greater degree than the tropics (polar amplification) remains poorly constrained, in particular because there are only a few temperature reconstructions from the tropics. Consequently, the relationship between increased CO 2 , the degree of tropical warming, and the resulting latitudinal SST gradient is not well known. Here, we present coupled clumped isotope (Δ 47 )-Mg/Ca measurements of foraminifera from a set of globally distributed sites in the tropics and midlatitudes. Δ 47 is insensitive to seawater chemistry and therefore provides a robust constraint on tropical SST. Crucially, coupling these data with Mg/Ca measurements allows the precise reconstruction of Mg/Ca sw throughout the Eocene, enabling the reinterpretation of all planktonic foraminifera Mg/Ca data. The combined dataset constrains the range in Eocene tropical SST to 30-36 °C (from sites in all basins). We compare these accurate tropical SST to deep-ocean temperatures, serving as a minimum constraint on high-latitude SST. This results in a robust conservative reconstruction of the early Eocene latitudinal gradient, which was reduced by at least 32 ± 10% compared with present day, demonstrating greater polar amplification than captured by most climate models.

Molecular mechanisms of the antiproliferative activity of somatostatin receptors (SSTRs) in neuroendocrine tumors.

PubMed

Florio, Tullio

2008-01-01

The current treatment of neuroendocrine tumors include the use of somatostatin (SST) agonists. These compounds are able to control most of the symptoms caused by the hypersecretory activity of the tumor cells, and for this reason, they provide a significant improvement in the well-being of the patients. Although, several reports also showed a possible direct antiproliferative activity of SST agonists in different neuroendocrine tumors, the therapeutic potential of an in vivo antiproliferative activity mediated by SST receptors is still debated. In recent years, there has been great insights on understanding the molecular basis of the antitumoral activity of SST that appears to be exerted via both direct and indirect mechanisms. Direct mechanisms require the activation of SST receptors in tumor cells and the induction of cell cycle arrest or apoptosis, mainly through the regulation of phosphotyrosine phosphatase (PTP) and MAP kinase activities. The indirect mechanisms involve the inhibition of tumor angiogenesis and the inhibition of the secretion of factors which are required for tumor growth. Here, we will review the molecular mechanisms which are implicated in the antiproliferative activity of SST. Such an understanding is necessary for improving the antitumoral efficacy of SSTR agonists as well as for the development of novel therapeutic strategies.

Model Predictive Control of A Matrix-Converter Based Solid State Transformer for Utility Grid Interaction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xue, Yaosuo

The matrix converter solid state transformer (MC-SST), formed from the back-to-back connection of two three-to-single-phase matrix converters, is studied for use in the interconnection of two ac grids. The matrix converter topology provides a light weight and low volume single-stage bidirectional ac-ac power conversion without the need for a dc link. Thus, the lifetime limitations of dc-bus storage capacitors are avoided. However, space vector modulation of this type of MC-SST requires to compute vectors for each of the two MCs, which must be carefully coordinated to avoid commutation failure. An additional controller is also required to control power exchange betweenmore » the two ac grids. In this paper, model predictive control (MPC) is proposed for an MC-SST connecting two different ac power grids. The proposed MPC predicts the circuit variables based on the discrete model of MC-SST system and the cost function is formulated so that the optimal switch vector for the next sample period is selected, thereby generating the required grid currents for the SST. Simulation and experimental studies are carried out to demonstrate the effectiveness and simplicity of the proposed MPC for such MC-SST-based grid interfacing systems.« less

Overall behaviour of PFC integrated SST-1 vacuum system

NASA Astrophysics Data System (ADS)

Khan, Ziauddin; Raval, Dilip C.; Paravasu, Yuvakiran; Semwal, Pratibha; Dhanani, Kalpeshkumar R.; George, Siju; Shoaib, Mohammad; Prakash, Arun; Babu, Gattu R.; Thankey, Prashant; Pathan, Firozkhan S.; Pradhan, Subrata

2017-04-01

As a part of phase-I up-gradation of Steady-state Superconducting Tokamak (SST-1), Graphite Plasma Facing Components (PFCs) have been integrated inside SST-1 vacuum vessel as a first wall (FW) during Nov 14 and May 2015. The SST-1 FW has a total surface area of the installed PFCs exposed to plasma is ∼ 40 m2 which is nearly 50% of the total surface area of stainless steel vacuum chamber (∼75 m2). The volume of the vessel within the PFCs is ∼ 16 m3. After the integration of PFCs, the entire vessel as well as the PFC cooling/baking circuits has been qualified with an integrated helium leak tightness of < 1.0 x 10-8 mbar 1/s. The pumping system of the SST-1 vacuum vessel comprises of one number of Roots’ pump, four numbers of turbomolecular pumps and a cryopump. After the initial pump down, the PFCs were baked at 250 °C for nearly 20 hours employing hot nitrogen gas to remove the absorbed water vapours. Thereafter, Helium glow discharges cleaning were carried out towards the removal of surface impurities. The pump down characteristics of SST-1 vacuum chamber and the changes in the residual gaseous impurities after the installation of the PFCs will be discussed in this paper.

Topical Administration of Somatostatin Prevents Retinal Neurodegeneration in Experimental Diabetes

PubMed Central

Hernández, Cristina; García-Ramírez, Marta; Corraliza, Lidia; Fernández-Carneado, Jimena; Farrera-Sinfreu, Josep; Ponsati, Berta; González-Rodríguez, Águeda; Valverde, Ángela M.; Simó, Rafael

2013-01-01

Retinal neurodegeneration is an early event in the pathogenesis of diabetic retinopathy (DR). Somatostatin (SST) is an endogenous neuroprotective peptide that is downregulated in the diabetic eye. The aim of the study was to test the usefulness of topical administration of SST in preventing retinal neurodegeneration. For this purpose, rats with streptozotocin-induced diabetes mellitus (STZ-DM) were treated with either SST eye drops or vehicle for 15 days. Nondiabetic rats treated with vehicle served as a control group. Functional abnormalities were assessed by electroretinography (ERG), and neurodegeneration was assessed by measuring glial activation and the apoptotic rate. In addition, proapoptotic (FasL, Bid, and activation of caspase-8 and caspase-3) and survival signaling pathways (BclxL) were examined. Intraretinal concentrations of glutamate and its main transporter glutamate/aspartate transporter (GLAST) were also determined. Treatment with SST eye drops prevented ERG abnormalities, glial activation, apoptosis, and the misbalance between proapoptotic and survival signaling detected in STZ-DM rats. In addition, SST eye drops inhibited glutamate accumulation in the retina and GLAST downregulation induced by diabetes mellitus. We conclude that topical administration of SST has a potent effect in preventing retinal neurodegeneration induced by diabetes mellitus. In addition, our findings open up a new preventive pharmacological strategy targeted to early stages of DR. PMID:23474487

Topical administration of somatostatin prevents retinal neurodegeneration in experimental diabetes.

PubMed

Hernández, Cristina; García-Ramírez, Marta; Corraliza, Lidia; Fernández-Carneado, Jimena; Farrera-Sinfreu, Josep; Ponsati, Berta; González-Rodríguez, Agueda; Valverde, Angela M; Simó, Rafael

2013-07-01

Retinal neurodegeneration is an early event in the pathogenesis of diabetic retinopathy (DR). Somatostatin (SST) is an endogenous neuroprotective peptide that is downregulated in the diabetic eye. The aim of the study was to test the usefulness of topical administration of SST in preventing retinal neurodegeneration. For this purpose, rats with streptozotocin-induced diabetes mellitus (STZ-DM) were treated with either SST eye drops or vehicle for 15 days. Nondiabetic rats treated with vehicle served as a control group. Functional abnormalities were assessed by electroretinography (ERG), and neurodegeneration was assessed by measuring glial activation and the apoptotic rate. In addition, proapoptotic (FasL, Bid, and activation of caspase-8 and caspase-3) and survival signaling pathways (BclxL) were examined. Intraretinal concentrations of glutamate and its main transporter glutamate/aspartate transporter (GLAST) were also determined. Treatment with SST eye drops prevented ERG abnormalities, glial activation, apoptosis, and the misbalance between proapoptotic and survival signaling detected in STZ-DM rats. In addition, SST eye drops inhibited glutamate accumulation in the retina and GLAST downregulation induced by diabetes mellitus. We conclude that topical administration of SST has a potent effect in preventing retinal neurodegeneration induced by diabetes mellitus. In addition, our findings open up a new preventive pharmacological strategy targeted to early stages of DR.

Enhancement of the spring East China precipitation response to tropical sea surface temperature variability

NASA Astrophysics Data System (ADS)

Zhang, Mengqi; Sun, Jianqi

2017-12-01

The boreal spring relationship between variabilities of East China precipitation (ECP) and tropical Ocean sea surface temperature (SST) during the period 1951-2014 is investigated in this study. The results show that the leading mode of the ECP variability exhibits an enhanced response to the anomalous El Niño-Southern Oscillation (ENSO)-like SST after the late 1970s, when the SST underwent a decadal change, with two positive centers over the eastern tropical Pacific (ETP) and tropical Indian Ocean (TIO). To further understand the relative roles of the ETP and TIO SST anomalies (SSTAs) in the variability of ECP after the late 1970s, partial regression and correlation methods are used. It is found that, without the contribution of the TIO, ETP SSTA plays a limited role in the variability of ECP after the late 1970s; comparatively, a significant correlation between TIO SST and ECP is identified during the same period, when the ETP signal is linearly removed. Physical analyses show that, after the late 1970s, the TIO SSTA affects East Asian atmospheric circulation in two ways: by exciting a zonal wave-train pattern over the mid-latitude Eurasian Continent and by inducing anomalous convection over the Maritime Continent. Via these two mechanisms, the TIO SST variability results in an anomalous East Asian trough and vertical motion over East China and consequently leads to anomalous precipitation over the region. The physical processes linking the ECP and TIO SST are confirmed by an atmospheric general circulation model experiment forced with idealized TIO warming.

Central Equatorial Pacific Sea Surface Temperatures During the Last Glacial Maximum

NASA Astrophysics Data System (ADS)

Monteagudo, M. M.; Lynch-Stieglitz, J.; Schmidt, M. W.

2017-12-01

The state of the tropical Pacific ocean-atmosphere system during the Last Glacial Maximum (LGM, 19,000-23,000 years BP) remains an area of uncertainty. Spatial patterns of tropical Pacific sea surface temperature (SST) offer insight into atmospheric circulation (i.e. Walker Circulation), however, few records exist for the Central Tropical Pacific (CTP). The few existing glacial CTP SST reconstructions indicate 1-2 °C of warming based on foraminiferal transfer functions (CLIMAP Project Members, 1976). In contrast, evidence from geochemical proxies (Mg/Ca, UK'37, TEX86) show 1-3.5 °C cooling in the eastern and western tropical Pacific (e.g. MARGO Project Members, 2009). In this study we present the first Mg/Ca estimates of glacial CTP SST from a meridional sediment core transect along the Line Islands Ridge (0-7°N, 156-162 °W). We use a time slice approach to establish the magnitude of glacial-interglacial SST change between the LGM (19,000-23,0000 years BP) and the Holocene (0-10,000 years BP) using Mg/Ca in the surface-dwelling foraminifera Globigerinoides ruber. Our results indicate cooling at all latitudes, ranging between 1.2-2.7 °C (Holocene-LGM SST). Northern cores (6.83-2.77 °N) exhibit a smaller glacial-interglacial SST difference than equatorial site 20BB at 1.27 °N. The data generated thus far suggest the glacial meridional SST gradient may have been steeper, possibly as a result of increased zonal winds, equatorial upwelling, or westward expansion of the Eastern Pacific Cold Tongue.

Pliocene Seasonality along the US Atlantic Coastal Plain Inferred from Growth Increment Analysis of Mercenaria carolinensis

NASA Astrophysics Data System (ADS)

Winkelstern, I. Z.; Surge, D. M.

2010-12-01

Pliocene sea surface temperature (SST) data from the US Atlantic coastal plain is currently insufficient for a detailed understanding of the climatic shifts that occurred during the period. Previous studies, based on oxygen isotope proxy data from marine shells and bryozoan zooid size analysis, have provided constraints on possible annual-scale SST ranges for the region. However, more data are required to fully understand the forcing mechanisms affecting regional Pliocene climate and evaluate modeled temperature projections. Bivalve sclerochronology (growth increment analysis) is an alternative proxy for SST that can provide annually resolved multi-year time series. The method has been validated in previous studies using modern Arctica, Chione, and Mercenaria. We analyzed Pliocene Mercenaria carolinensis shells using sclerochronologic methods and tested the hypothesis that higher SST ranges are reflected in shells selected from the warmest climate interval (3.5-3.3 Ma, upper Yorktown Formation, Virginia) and lower SST ranges are observable in shells selected from the subsequent cooling interval (2.4-1.8 Ma, Chowan River Formation, North Carolina). These results further establish the validity of growth increment analysis using fossil shells and provide the first large dataset (from the region) of reconstructed annual SST from floating time series during these intervals. These data will enhance our knowledge about a warm climate state that has been identified in the 2007 IPCC report as an analogue for expected global warming. Future work will expand this study to include sampling in Florida to gain detailed information about Pliocene SST along a latitudinal gradient.

Uncertainties and coupled error covariances in the CERA-20C, ECMWF's first coupled reanalysis ensemble

NASA Astrophysics Data System (ADS)

Feng, Xiangbo; Haines, Keith

2017-04-01

ECMWF has produced its first ensemble ocean-atmosphere coupled reanalysis, the 20th century Coupled ECMWF ReAnalysis (CERA-20C), with 10 ensemble members at 3-hour resolution. Here the analysis uncertainties (ensemble spread) of lower atmospheric variables and sea surface temperature (SST), and their correlations, are quantified on diurnal, seasonal and longer timescales. The 2-m air temperature (T2m) spread is always larger than the SST spread at high-frequencies, but smaller on monthly timescales, except in deep convection areas, indicating increasing SST control at longer timescales. Spatially the T2m-SST ensemble correlations are the strongest where ocean mixed layers are shallow and can respond to atmospheric variability. Where atmospheric convection is strong with a deep precipitating boundary layer, T2m-SST correlations are greatly reduced. As the 20th-century progresses more observations become available, and ensemble spreads decline at all variability timescales. The T2m-SST correlations increase through the 20th-century, except in the tropics. As winds become better constrained over the oceans with less spread, T2m-SST become more correlated. In the tropics, strong ENSO-related inter-annual variability is found in the correlations, as atmospheric convection centres move. These ensemble spreads have been used to provide background errors for the assimilation throughout the reanalysis, have implications for the weights given to observations, and are a general measure of the uncertainties in the analysed product. Although cross boundary covariances are not currently used, they offer considerable potential for strengthening the ocean-atmosphere coupling in future reanalyses.

Coupled assimilation for an intermediated coupled ENSO prediction model

NASA Astrophysics Data System (ADS)

Zheng, Fei; Zhu, Jiang

2010-10-01

The value of coupled assimilation is discussed using an intermediate coupled model in which the wind stress is the only atmospheric state which is slavery to model sea surface temperature (SST). In the coupled assimilation analysis, based on the coupled wind-ocean state covariance calculated from the coupled state ensemble, the ocean state is adjusted by assimilating wind data using the ensemble Kalman filter. As revealed by a series of assimilation experiments using simulated observations, the coupled assimilation of wind observations yields better results than the assimilation of SST observations. Specifically, the coupled assimilation of wind observations can help to improve the accuracy of the surface and subsurface currents because the correlation between the wind and ocean currents is stronger than that between SST and ocean currents in the equatorial Pacific. Thus, the coupled assimilation of wind data can decrease the initial condition errors in the surface/subsurface currents that can significantly contribute to SST forecast errors. The value of the coupled assimilation of wind observations is further demonstrated by comparing the prediction skills of three 12-year (1997-2008) hindcast experiments initialized by the ocean-only assimilation scheme that assimilates SST observations, the coupled assimilation scheme that assimilates wind observations, and a nudging scheme that nudges the observed wind stress data, respectively. The prediction skills of two assimilation schemes are significantly better than those of the nudging scheme. The prediction skills of assimilating wind observations are better than assimilating SST observations. Assimilating wind observations for the 2007/2008 La Niña event triggers better predictions, while assimilating SST observations fails to provide an early warning for that event.

Sensitivity of Pacific Cold Tongue and Double-ITCZ Bias to Convective Parameterization

NASA Astrophysics Data System (ADS)

Woelfle, M.; Bretherton, C. S.; Pritchard, M. S.; Yu, S.

2016-12-01

Many global climate models struggle to accurately simulate annual mean precipitation and sea surface temperature (SST) fields in the tropical Pacific basin. Precipitation biases are dominated by the double intertropical convergence zone (ITCZ) bias where models exhibit precipitation maxima straddling the equator while only a single Northern Hemispheric maximum exists in observations. The major SST bias is the enhancement of the equatorial cold tongue. A series of coupled model simulations are used to investigate the sensitivity of the bias development to convective parameterization. Model components are initialized independently prior to coupling to allow analysis of the transient response of the system directly following coupling. These experiments show precipitation and SST patterns to be highly sensitive to convective parameterization. Simulations in which the deep convective parameterization is disabled forcing all convection to be resolved by the shallow convection parameterization showed a degradation in both the cold tongue and double-ITCZ biases as precipitation becomes focused into off-equatorial regions of local SST maxima. Simulations using superparameterization in place of traditional cloud parameterizations showed a reduced cold tongue bias at the expense of additional precipitation biases. The equatorial SST responses to changes in convective parameterization are driven by changes in near equatorial zonal wind stress. The sensitivity of convection to SST is important in determining the precipitation and wind stress fields. However, differences in convective momentum transport also play a role. While no significant improvement is seen in these simulations of the double-ITCZ, the system's sensitivity to these changes reaffirm that improved convective parameterizations may provide an avenue for improving simulations of tropical Pacific precipitation and SST.

Interannual to Decadal SST Variability in the Tropical Indian Ocean

NASA Astrophysics Data System (ADS)

Wang, G.; Newman, M.; Han, W.

2017-12-01

The Indian Ocean has received increasing attention in recent years for its large impacts on regional and global climate. However, due mainly to the close interdependence of the climate variation within the Tropical Pacific and the Indian Ocean, the internal sea surface temperature (SST) variability within the Indian Ocean has not been studied extensively on longer time scales. In this presentation we will show analysis of the interannual to decadal SST variability in the Tropical Indian Ocean in observations and Linear Inverse Model (LIM) results. We also compare the decoupled Indian Ocean SST variability from the Pacific against fully coupled one based on LIM integrations, to test the factors influence the features of the leading SST modes in the Indian Ocean. The result shows the Indian Ocean Basin (IOB) mode, which is strongly related to global averaged SST variability, passively responses to the Pacific variation. Without tropical Indo-Pacific coupling interaction, the intensity of IOB significantly decreases by 80%. The Indian Ocean Dipole (IOD) mode demonstrates its independence from the Pacific SST variability since the IOD does not change its long-term characteristics at all without inter-basin interactions. The overall SSTA variance decreases significantly in the Tropical Indian Ocean in the coupling restricted LIM runs, especially when the one-way impact from the Pacific to the Indian Ocean is turned off, suggesting that most of the variability in the Indian Ocean comes from the Pacific influence. On the other hand, the Indian Ocean could also transport anomalies to the Pacific, making the interaction a complete two-way process.

Shuttle swimming test in young water polo players: reliability, responsiveness and age-related value.

PubMed

Melchiorri, Giovanni; Viero, Valerio; Triossi, Tamara; Padua, Elvira; Bonifazi, Marco

2017-11-01

This study investigated the applicability of a sport-specific test, the Shuttle Swim Test, in young water polo players to measure RSA. The aims were: to assess the reliability and to measure the responsiveness of the SST in young water polo athletes, and to provide age-related values of SST. Three hundred thirty-three elite athletes (18.3±5.1 years) were involved in the study. Of these, 99 were young people under 13 (13.1±0.5 years) who also underwent measurements for reliability and responsiveness of the SST The following six measures was used to assess anthropometric characteristics of the sample: height, weight, chest circumference, hip circumference, waist circumference, and arm span. Two performance measures were performed on dry land: push up and chin up. Reliability and responsiveness were measured by comparing the average speed of two trials: SST1 was 1.48±0.13 m·s-1 and SST2 1.47±.12 m·s-1. The SST showed good reliability in younger athletes (r=0.96). The Minimal Detectable Change is 0.06 m·s-1 (6 seconds of the total time) which corresponds to 3.6% of the average value measured, confirming the good responsiveness of the test. Coaches and researchers can use this value in the interpretation of the SST test results: changes below these values could be related to a measurement error. The various age-related values reported may help technicians to better interpret the performance of their athletes during competition.

West-WRF Sensitivity to Sea Surface Temperature Boundary Condition in California Precipitation Forecasts of AR Related Events

NASA Astrophysics Data System (ADS)

Zhang, X.; Cornuelle, B. D.; Martin, A.; Weihs, R. R.; Ralph, M.

2017-12-01

We evaluated the merit in coastal precipitation forecasts by inclusion of high resolution sea surface temperature (SST) from blended satellite and in situ observations as a boundary condition (BC) to the Weather Research and Forecast (WRF) mesoscale model through simple perturbation tests. Our sensitivity analyses shows that the limited improvement of watershed scale precipitation forecast is credible. When only SST BC is changed, there is an uncertainty introduced because of artificial model state equilibrium and the nonlinear nature of the WRF model system. With the change of SST on the order of a fraction of a degree centigrade, we found that the part of random perturbation forecast response is saturated after 48 hours when it reaches to the order magnitude of the linear response. It is important to update the SST at a shorter time period, so that the independent excited nonlinear modes can cancel each other. The uncertainty in our SST configuration is quantitatively equivalent to adding to a spatially uncorrelated Guasian noise of zero mean and 0.05 degree of standard deviation to the SST. At this random noise perturbation magnitude, the ensemble average behaves well within a convergent range. It is also found that the sensitivity of forecast changes in response to SST changes. This is measured by the ratio of the spatial variability of mean of the ensemble perturbations over the spatial variability of the corresponding forecast. The ratio is about 10% for surface latent heat flux, 5 % for IWV, and less than 1% for surface pressure.

Oxidation and gum formation in diesel fuels. Interim technical report, May-December 1985

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mayo, F.R.

1985-12-20

This Report describes experiments on oxidation and gum formation from n-dodecane, tetralin, and several diesel fuels at 43, 60, and 100 C, with and without added initiators, t-butyl peroxide and 2,2'azobis(2-methylpropionitrile) (ABN). Experiments on gum determination and a manuscript for publication, Gum and Deposit Formation from Jet Turbine and Diesel Fuels at 100 C, are included. One objective of work on this Contract is to relate oxidations of diesel fuels at 100 and 130 C, where experiments can be performed in hours or days, to standard tests for fuel stability at ambient temperatures and 43.3 C (110 F), which requiremore » many weeks. A second objective is to devise a fast test for fuel stability.« less

Eye bank prepared versus surgeon cut endothelial graft tissue for Descemet membrane endothelial keratoplasty: An observational study.

PubMed

Regnier, Marie; Auxenfans, Céline; Maucort-Boulch, Delphine; Marty, Anne-Sophie; Damour, Odile; Burillon, Carole; Kocaba, Viridiana

2017-05-01

The purpose of this article is to examine outcomes of Descemet membrane endothelial keratoplasty (DMEK) performed with cornea bank (CB) prestripped tissue and surgeon stripped tissue (SST).This retrospective study examined subjects who underwent DMEK with CB or surgeon prepared tissue for Fuchs endothelial corneal dystrophy. Best-corrected visual acuity (BCVA), corneal thickness, endothelial cell count (ECC), and complications were examined before and throughout a 6-month postoperative period.Eleven CB and 22 SST subjects were included. Six months after surgery, BCVA was 20/20 or better in 36.4% of CB and 22.7% of SST subjects (P = .43). Median logMAR BCVA was 0.10 (0.00-0.20, 20/25) in group CB and 0.10 (0.10-0.30, 20/25) in group SST. Median preoperative corneal thickness was 614.0 μm (577.5-662.0 μm) and 658.0 μm (606.0-689.0 μm) in CB and SST subjects, respectively (P = .37). Six months after surgery, median corneal thickness was lower in the CB group (571.0 μm [478.0-592.0 μm]), than in the SST group (576.0 μm [531.0-607.0 μm], P = .02). At 6 months, median ECC was 1500.0 cell/mm (1321.5-2049.0 cell/mm, 41% decrease) in group CB and 1403.0 cell/mm (972.5-2010.7 cell/mm, 46% decrease) in group SST (P = .70). Rebubbling was required in 5 CB (45.5%) and 15 SST (68.2%) subjects (P = .39).Fuchs' dystrophy patients have good anatomic and functional DMEK results. Similar outcomes and complication rates occurred with eye bank and surgeon prepared donor tissue.

High Resolution Upwelling Cycles in Guaymas and Cariaco Basins over the late Holocene: Coupling Between the Western Atlantic and Eastern Pacific?

NASA Astrophysics Data System (ADS)

Goni, M. A.

2005-12-01

The recent past history of sea surface temperature (SST) conditions in two wind-dominated upwelling systems, Guaymas Basin (Gulf of California) and Cariaco Basin (Venezuela) was investigated using the alkenone-based UK'37 index. Both of these systems undergo marked seasonal SST changes of 4-10 degrees C, which are associated with wind-driven upwelling and thermal stratification cycles. Both Guaymas and Cariaco Basins are also characterized by suboxic to anoxic bottom waters that result in undisturbed, varved sediments. Confirmation that the seasonal SST trends are accurately incorporated into the UK'37 ratios of sinking particles was achieved using sediment trap samples. Analyses of sediment cores from Guaymas and Cariaco Basins yielded high-resolution (decadal) records of SST conditions in the overlying water column from 1700 to 2000 AD. The trends in the UK'37 index revealed general increases in the SST at both sites over that last 300 years associated with the end of the little ice age. However, in addition to this long-term trend, higher-frequency (~ 50 years) changes in SST that ranged from 1-3 degrees C were observed. We speculate that these decadal trends in SST reflect variations in the intensity of wind-driven upwelling at these sites. Most interestingly, there is a marked contrast in the timing of the SST values between Guaymas and Cariaco so that periods of enhanced upwelling in Guyamas Basin are characterized by decreased upwelling in Cariaco Basin (and vice versa). We propose that these contrasting records reflect differences in the response of wind-driven upwelling to changes in the position of the Intertropical Convergence Zone over the western Atlantic and the subtropical High over the eastern Pacific. The connection between these two upwelling systems and its significance for paleoreconstruction studies will be explored further.

Prognostic Value of Soluble Suppression of Tumorigenicity-2 in Chronic Heart Failure: A Meta-Analysis.

PubMed

Aimo, Alberto; Vergaro, Giuseppe; Passino, Claudio; Ripoli, Andrea; Ky, Bonnie; Miller, Wayne L; Bayes-Genis, Antoni; Anand, Inder; Januzzi, James L; Emdin, Michele

2017-04-01

The purpose of this study was to perform the first meta-analysis of currently available data. Soluble suppression of tumorigenesis 2 (sST2) plasma concentration is elevated in chronic heart failure (CHF) and helps to predict prognosis in this setting, although the evidence is limited. Three databases (Medline, Cochrane Library, and Scopus) were searched. Inclusion criteria were: follow-up studies; papers published in English; enrollment of CHF outpatients; available data on hazard ratio (HR) for the log 2 ST2 (so that the reported HRs represent the risk per doubling of sST2) and 95% confidence interval (CI) for all-cause death, and possibly also for cardiovascular (CV) death; and use of standardized sST2 assay. Exclusion criteria were: sST2 considered only as an element of a prognostic score, and studies on patients with end-stage HF. Seven studies were finally included for all-cause death, with a global population of 6,372 patients; data on CV death were available for 5 studies, totaling 5,051 patients. The HR was 1.75 (95% CI: 1.37 to 2.22) for all-cause death and 1.79 (95% CI: 1.22 to 2.63) for CV death (both p < 0.001). Significant heterogeneity among studies was detected in the quantification of sST2 predictive value, attributable to marked differences in pharmacological treatment among trials. The predictive power of sST2 was greater when patients were managed according to present guideline-recommended medical treatment. sST2 is a predictor of both all-cause and CV death in CHF outpatients. The present meta-analysis supports the use of sST2 for risk stratification in patients with stable CHF. Copyright © 2017 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Impact of the Gulf of California SST on simulating precipitation and crop productivity in the Southwestern United States

NASA Astrophysics Data System (ADS)

Kim, S.; Kim, J.; Prasad, A. K.; Stack, D. H.; El-Askary, H. M.; Kafatos, M.

2012-12-01

Like other ecosystems, agricultural productivity is substantially affected by climate factors. Therefore, accurate climatic data (i.e. precipitation, temperature, and radiation) is crucial to simulating crop yields. In order to understand and anticipate climate change and its impacts on agricultural productivity in the Southwestern United States, the WRF regional climate model (RCM) and the Agricultural Production Systems sIMulator (APSIM) were employed for simulating crop production. 19 years of WRF RCM output show that there is a strong dry bias during the warm season, especially in Arizona. Consequently, the APSIM crop model indicates very low crop yields in this region. We suspect that the coarse resolution of reanalysis data could not resolve the relatively warm Sea Surface Temperature (SST) in the Gulf of California (GC), causing the SST to be up to 10 degrees lower than the climatology. In the Southwestern United States, a significant amount of precipitation is associated with North American Monsoon (NAM). During the monsoon season, the low-level moisture is advected to the Southwestern United States via the GC, which is known to be the dominant moisture source. Thus, high-resolution SST data in the GC is required for RCM simulations to accurately represent a reasonable amount of precipitation in the region, allowing reliable evaluation of the impacts on regional ecosystems.and evaluate impacts on regional ecosystems. To evaluate the influence of SST on agriculture in the Southwestern U.S., two sets of numerical simulations were constructed: a control, using unresolved SST of GC, and daily updated SST data from the MODIS satellite sensor. The meteorological drivers from each of the 6 year RCM runs were provided as input to the APSIM model to determine the crop yield. Analyses of the simulated crop production, and the interannual variation of the meteorological drivers, demonstrate the influence of SST on crop yields in the Southwestern United States.

Sea Surface Temperature Influence on Terrestrial Gross Primary Production along the Southern California Current.

PubMed

Reimer, Janet J; Vargas, Rodrigo; Rivas, David; Gaxiola-Castro, Gilberto; Hernandez-Ayon, J Martin; Lara-Lara, Ruben

2015-01-01

Some land and ocean processes are related through connections (and synoptic-scale teleconnections) to the atmosphere. Synoptic-scale atmospheric (El Niño/Southern Oscillation [ENSO], Pacific Decadal Oscillation [PDO], and North Atlantic Oscillation [NAO]) decadal cycles are known to influence the global terrestrial carbon cycle. Potentially, smaller scale land-ocean connections influenced by coastal upwelling (changes in sea surface temperature) may be important for local-to-regional water-limited ecosystems where plants may benefit from air moisture transported from the ocean to terrestrial ecosystems. Here we use satellite-derived observations to test potential connections between changes in sea surface temperature (SST) in regions with strong coastal upwelling and terrestrial gross primary production (GPP) across the Baja California Peninsula. This region is characterized by an arid/semiarid climate along the southern California Current. We found that SST was correlated with the fraction of photosynthetic active radiation (fPAR; as a proxy for GPP) with lags ranging from 0 to 5 months. In contrast ENSO was not as strongly related with fPAR as SST in these coastal ecosystems. Our results show the importance of local-scale changes in SST during upwelling events, to explain the variability in GPP in coastal, water-limited ecosystems. The response of GPP to SST was spatially-dependent: colder SST in the northern areas increased GPP (likely by influencing fog formation), while warmer SST at the southern areas was associated to higher GPP (as SST is in phase with precipitation patterns). Interannual trends in fPAR are also spatially variable along the Baja California Peninsula with increasing secular trends in subtropical regions, decreasing trends in the most arid region, and no trend in the semi-arid regions. These findings suggest that studies and ecosystem process based models should consider the lateral influence of local-scale ocean processes that could influence coastal ecosystem productivity.

Sea Surface Temperature Influence on Terrestrial Gross Primary Production along the Southern California Current

PubMed Central

Reimer, Janet J.; Vargas, Rodrigo; Rivas, David; Gaxiola-Castro, Gilberto; Hernandez-Ayon, J. Martin; Lara-Lara, Ruben

2015-01-01

Some land and ocean processes are related through connections (and synoptic-scale teleconnections) to the atmosphere. Synoptic-scale atmospheric (El Niño/Southern Oscillation [ENSO], Pacific Decadal Oscillation [PDO], and North Atlantic Oscillation [NAO]) decadal cycles are known to influence the global terrestrial carbon cycle. Potentially, smaller scale land-ocean connections influenced by coastal upwelling (changes in sea surface temperature) may be important for local-to-regional water-limited ecosystems where plants may benefit from air moisture transported from the ocean to terrestrial ecosystems. Here we use satellite-derived observations to test potential connections between changes in sea surface temperature (SST) in regions with strong coastal upwelling and terrestrial gross primary production (GPP) across the Baja California Peninsula. This region is characterized by an arid/semiarid climate along the southern California Current. We found that SST was correlated with the fraction of photosynthetic active radiation (fPAR; as a proxy for GPP) with lags ranging from 0 to 5 months. In contrast ENSO was not as strongly related with fPAR as SST in these coastal ecosystems. Our results show the importance of local-scale changes in SST during upwelling events, to explain the variability in GPP in coastal, water-limited ecosystems. The response of GPP to SST was spatially-dependent: colder SST in the northern areas increased GPP (likely by influencing fog formation), while warmer SST at the southern areas was associated to higher GPP (as SST is in phase with precipitation patterns). Interannual trends in fPAR are also spatially variable along the Baja California Peninsula with increasing secular trends in subtropical regions, decreasing trends in the most arid region, and no trend in the semi-arid regions. These findings suggest that studies and ecosystem process based models should consider the lateral influence of local-scale ocean processes that could influence coastal ecosystem productivity. PMID:25923109

Pattern Analysis of El Nino and La Nina Phenomenon Based on Sea Surface Temperature (SST) and Rainfall Intensity using Oceanic Nino Index (ONI) in West Java Area

NASA Astrophysics Data System (ADS)

Prasetyo, Yudo; Nabilah, Farras

2017-12-01

Climate change occurs in 1998-2016 brings significant alteration in the earth surface. It is affects an extremely anomaly temperature such as El Nino and La Nina or mostly known as ENSO (El Nino Southern Oscillation). West Java is one of the regions in Indonesia that encounters the impact of this phenomenon. Climate change due to ENSO also affects food production and other commodities. In this research, processing data method is conducted using programming language to process SST data and rainfall data from 1998 to 2016. The data are sea surface temperature from NOAA satellite, SST Reynolds (Sea Surface Temperature) and daily rainfall temperature from TRMM satellite. Data examination is done using analysis of rainfall spatial pattern and sea surface temperature (SST) where is affected by El Nino and La Nina phenomenon. This research results distribution map of SST and rainfall for each season to find out the impacts of El Nino and La Nina around West Java. El Nino and La Nina in Java Sea are occurring every August to February. During El Nino, sea surface temperature is between 27°C - 28°C with average temperature on 27.71°C. Rainfall intensity is 1.0 mm/day - 2.0 mm/day and the average are 1.63 mm/day. During La Nina, sea surface temperature is between 29°C - 30°C with average temperature on 29.06°C. Rainfall intensity is 9.0 mm/day - 10 mm/day, and the average is 9.74 mm/day. The correlation between rainfall and SST is 0,413 which is expresses a fairly strong correlation between parameters. The conclusion is, during La Nina SST and rainfall increase. While during El Nino SST and rainfall decrease. Hopefully this research could be a guideline to plan disaster mitigation in West Java region that is related extreme climate change.

Feasibility Study of LANDSAT-8 Imagery for Retrieving Sea Surface Temperature (case Study Persian Gulf)

NASA Astrophysics Data System (ADS)

Bayat, F.; Hasanlou, M.

2016-06-01

Sea surface temperature (SST) is one of the critical parameters in marine meteorology and oceanography. The SST datasets are incorporated as conditions for ocean and atmosphere models. The SST needs to be investigated for various scientific phenomenon such as salinity, potential fishing zone, sea level rise, upwelling, eddies, cyclone predictions. On the other hands, high spatial resolution SST maps can illustrate eddies and sea surface currents. Also, near real time producing of SST map is suitable for weather forecasting and fishery applications. Therefore satellite remote sensing with wide coverage of data acquisition capability can use as real time tools for producing SST dataset. Satellite sensor such as AVHRR, MODIS and SeaWIFS are capable of extracting brightness values at different thermal spectral bands. These brightness temperatures are the sole input for the SST retrieval algorithms. Recently, Landsat-8 successfully launched and accessible with two instruments on-board: (1) the Operational Land Imager (OLI) with nine spectral bands in the visual, near infrared, and the shortwave infrared spectral regions; and (2) the Thermal Infrared Sensor (TIRS) with two spectral bands in the long wavelength infrared. The two TIRS bands were selected to enable the atmospheric correction of the thermal data using a split window algorithm (SWA). The TIRS instrument is one of the major payloads aboard this satellite which can observe the sea surface by using the split-window thermal infrared channels (CH10: 10.6 μm to 11.2 μm; CH11: 11.5 μm to 12.5 μm) at a resolution of 30 m. The TIRS sensors have three main advantages comparing with other previous sensors. First, the TIRS has two thermal bands in the atmospheric window that provide a new SST retrieval opportunity using the widely used split-window (SW) algorithm rather than the single channel method. Second, the spectral filters of TIRS two bands present narrower bandwidth than that of the thermal band on board on previous Landsat sensors. Third, TIRS is one of the best space born and high spatial resolution with 30 m. in this regards, Landsat-8 can use the Split-Window (SW) algorithm for retrieving SST dataset. Although several SWs have been developed to use with other sensors, some adaptations are required in order to implement them for the TIRS spectral bands. Therefore, the objective of this paper is to develop a SW, adapted for use with Landsat-8 TIRS data, along with its accuracy assessment. In this research, that has been done for modelling SST using thermal Landsat 8-imagery of the Persian Gulf. Therefore, by incorporating contemporary in situ data and SST map estimated from other sensors like MODIS, we examine our proposed method with coefficient of determination (R2) and root mean square error (RMSE) on check point to model SST retrieval for Landsat-8 imagery. Extracted results for implementing different SW's clearly shows superiority of utilized method by R2 = 0.95 and RMSE = 0.24.

The roles of static stability and tropical-extratropical interactions in the summer interannual variability of the North Atlantic sector

NASA Astrophysics Data System (ADS)

Mbengue, Cheikh Oumar; Woollings, Tim; Dacre, Helen F.; Hodges, Kevin I.

2018-04-01

Summer seasonal forecast skill in the North Atlantic sector is lower than winter skill. To identify potential controls on predictability, the sensitivity of North Atlantic baroclinicity to atmospheric drivers is quantified. Using ERA-INTERIM reanalysis data, North Atlantic storm-track baroclinicity is shown to be less sensitive to meridional temperature-gradient variability in summer. Static stability shapes the sector's interannual variability by modulating the sensitivity of baroclinicity to variations in meridional temperature gradients and tropopause height and by modifying the baroclinicity itself. High static stability anomalies at upper levels result in more zonal extratropical cyclone tracks and higher eddy kinetic energy over the British Isles in the summertime. These static stability anomalies are not strongly related to the summer NAO; but they are correlated with the suppression of convection over the tropical Atlantic and with a poleward-shifted subtropical jet. These results suggest a non-local driver of North Atlantic variability. Furthermore, they imply that improved representations of convection over the south-eastern part of North America and the tropical Atlantic might improve summer seasonal forecast skill.

Stability of athlete blood passport parameters during air freight.

PubMed

Ashenden, M; Sharpe, K; Plowman, J; Allbon, G; Lobigs, L; Baron, A; Gore, C J

2014-10-01

Fluctuations in ambient temperature and pressure, as well as physical jostling, may affect the stability of whole blood samples transported by air freight. The aim of this study was to characterize the stability of key blood variables during air freight and to investigate whether vibration or reduced pressure alone affected results. Over a 72-h interval, we evaluated the stability of full blood count indices (plus reticulocytes) in tubes that were air-freighted a total of 2, 10 and 28 h. We also examined the impact of 24 h of reduced atmospheric pressure (750 hpa or approximately 2500 m.a.s.l) and vibration (5 Hz). Samples were measured on a Sysmex XT-2000i instrument. The two key variables in the context of antidoping (haemoglobin concentration, reticulocytes) remained stable over a 72-h period regardless of the duration of air freight. Atmospheric pressure and vibration had no discernible effect. Whole blood samples stored in NanoCool devices can be relied upon to remain stable for at least 72 h despite interim air freight. © 2013 John Wiley & Sons Ltd.

A Group-Administered Social Skills Training for 8- to 12-Year-Old, High-Functioning Children with Autism Spectrum Disorders: An Evaluation of Its Effectiveness in a Naturalistic Outpatient Treatment Setting

ERIC Educational Resources Information Center

Deckers, Anne; Muris, Peter; Roelofs, Jeffrey; Arntz, Arnoud

2016-01-01

A social skills training (SST) for high-functioning children with autism spectrum disorders (ASD) was evaluated in an outpatient setting using a combined between- and within-subject design in which SST and a waiting list condition were compared. According to parents and teachers, the SST produced greater improvement of social skills than the…

Evidence and mechanism of Hurricane Fran-Induced ocean cooling in the Charleston Trough

NASA Astrophysics Data System (ADS)

Xie, Lian; Pietrafesa, L. J.; Bohm, E.; Zhang, C.; Li, X.

Evidence of enhanced sea surface cooling during and following the passage of Hurricane Fran in September 1996 over an oceanic depression located on the ocean margin offshore of Charleston, South Carolina (referred to as the Charleston Trough), [Pietrafesa, 1983] is documented. Approximately 4C° of sea surface temperature (SST) reduction within the Charleston Trough following the passage of Hurricane Fran was estimated based on SST imagery from Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-14 polar orbiting satellite. Simulations using a three-dimensional coastal ocean model indicate that the largest SST reduction occurred within the Charleston Trough. This SST reduction can be explained by oceanic mixing due to storm-induced internal inertia-gravity waves.

Interim prostacyclin therapy for an isolated disconnected pulmonary artery: a case report

PubMed Central

2010-01-01

Introduction Disconnected pulmonary arteries are unusual and may result in pulmonary hypertension with acute right heart failure. Case presentation We report a case of a three-month-old Asian girl who presented with heart failure and severe pulmonary hypertension due to a disconnected right pulmonary artery. An epoprostenol (prostacyclin) infusion was instrumental in lowering pulmonary artery pressures and stabilizing the child prior to surgery. Conclusions This is, to the best of our knowledge, the first report of successful prostacyclin usage in such a situation. PMID:20525186

Assessment of the Coral Temperature Proxies for Orbicella faveolata in the Southwestern Gulf of Mexico

NASA Astrophysics Data System (ADS)

Vara, M. A.; DeLong, K. L.; Herrmann, A. D.; Ouellette, G., Jr.; Richey, J. N.

2017-12-01

Coral Sr/Ca is a robust proxy of sea surface temperature (SST); however, discrepancies in the Sr/Ca-SST relationship among colonies of the same species may reduce confidence in absolute temperature reconstructions. Furthermore, terrestrial carbonate weathering can provide local sources of Sr and/or Ca to coastal waters that may disrupt the temperature-based coral Sr/Ca signal. Thus other trace metal SST proxies have been suggested to circumvent these issues (Li/Ca, Li/Mg, and Sr-U). Coral Ba/Ca has been used as a proxy for runoff and coastal upwelling, and therefore may be used to identify intervals when these processes overprint the Sr/Ca-SST signal. This study tests multiple coral SST proxies using reproducibility assessments to determine the best performing SST proxy. We conduct these assessments with cores recovered in 1991 by the U.S. Geological Survey from five Orbicella faveolata colonies from three reefs offshore of Veracruz, Mexico (19.06°N, 96.93°W) in water depths varying from 3 to 12 m. Previous studies found micromilling the complex skeletal structure of O. faveolata challenging and that monthly resolution may not recover full seasonal cycles. We use a laser ablation inductively coupled plasma mass spectrometer to simultaneously sample this coral's structure at weekly intervals spanning 8 years for Li/Ca, Li/Mg, Sr-U, Sr/Ca, and Ba/Ca. Here we found coral Li/Ca means and seasonal variations are similar among colonies thus this proxy may capture absolute temperature and SST variability. Similar to previous research with Porites corals, Li/Ca in these O. faveolata corals decreases with increases in SST with similar slopes and intercepts. During the last 10 years of these corals' lives, coral Sr/Ca analysis reveals a mean shift among colonies suggesting an external source could have disrupted the Sr/Ca signal, possibly seasonal runoff and/or winter upwelling common to Veracruz waters. Coral Ba/Ca analyses reveals elevated values in winters that coincide with increases in coral Sr/Ca in the deeper colony suggesting upwelling is occurring at that location. However, the coral Ba/Ca does not coincide with increase coral Sr/Ca in the shallower coral indicating no direct influence from runoff. Coral Li/Mg and Sr-U do not show substantial seasonal variations as expected with a coral-SST proxy.

Salinity information in coral δ18O records

NASA Astrophysics Data System (ADS)

Conroy, J. L.; Thompson, D. M.; Dassié, E. P.; Stevenson, S.; Konecky, B. L.; DeLong, K. L.; Sayani, H. R.; Emile-Geay, J.; Partin, J. W.; Abram, N. J.; Martrat, B.

2017-12-01

Coral oxygen isotopic ratios (δ18O) are typically utilized to reconstruct sea surface temperature (SST), or SST-based El Niño-Southern Oscillation metrics (e.g., NIÑO3.4), despite the influence of both SST and the oxygen isotopic composition of seawater (δ18Osw) on coral δ18O. The ideal way to isolate past δ18Osw variations is to develop independent and univariate SST and δ18Osw responders, for instance, via paired coral δ18O and Sr/Ca analyses. Nonetheless, many coral δ18O records without paired Sr/Ca records already exist in the paleoclimatic literature, and these may be able to provide some insight into past δ18Osw and salinity changes due to the nature of the significant positive relationship between instrumental salinity and δ18Osw. Here we use coral δ18O records from the new PAGES Iso2k database to assess the regions in which coral δ18O has the greatest potential to provide salinity information based on the strength of the relationship between instrumental salinity and coral δ18O values. We find from annual pseudocoral similations that corals in the western tropical Pacific share a substantial fraction of their variance with δ18Osw rather than SST. In contrast, in the Indian Ocean and eastern tropical Pacific it is SST that predominantly explains coral δ18O variance. In agreement with this variance decomposition, we find that coral δ18O time series from the western tropical Pacific are significantly correlated with mid to late 20th century salinity. However, variations in the strength of the δ18Osw-salinity relationship across the western tropical Pacific will likely have a significant influence on coral δ18O-based salinity reconstructions. Additionally, in some cases a strong, negative correlation between SST and δ18Osw might not allow their influences to be adequately separated in coral δ18O records without the use of coupled Sr/Ca estimates of the temperature contribution. Overall, we find a range of modern salinity and SST correlations using instrumental data, which imply that high SST can be coincident with high salinity, low salinity, or there may be no significant relationship, implying that site-dependent assessments are crucial in attempts to use coral δ18O records to assess past salinity changes.

The global warming in the North Atlantic Sector and the role of the ocean

NASA Astrophysics Data System (ADS)

Hand, R.; Keenlyside, N. S.; Greatbatch, R. J.; Omrani, N. E.

2014-12-01

This work presents an analysis of North Atlantic ocean-atmosphere interaction in a warming climate, based on a long-term earth system model experiment forced by the RCP 8.5 scenario, the strongest greenhouse gas forcing used in the climate projections for the 5th Assessement report of the Intergovernmental Panel on Climate Change). In addition to a global increase in SSTs as a direct response to the radiative forcing, the model shows a distinct change of the local sea surface temperature (SST hereafter) patterns in the Gulf Stream region: The SST front moves northward by several hundred kilometers, likely as a response of the wind-driven part of the oceanic surface circulation, and becomes more zonal. As a consequence of a massive slowdown of the Atlantic Meridional Overturning Circulation, the northeast North Atlantic only shows a moderate warming compared to the rest of the ocean. The feedback of these changes on the atmosphere was studied in a set of sensitivity experiments based on the SST climatology of the coupled runs. The set consists of a control run based on the historical run, a run using the full SST from the coupled RCP 8.5 run and two runs, where the SST signal was deconstructed into a homogenous mean warming part and a local pattern change. In the region of the precipitation maximum in the historical run the future scenario shows an increase of absolute SSTs, but a significant decrease in local precipitation, low-level convergence and upward motion. Since warmer SSTs usually cause the opposite, this indicates that the local response in that region is connected to the (with respect to the historical run) weakened SST gradients rather than to the absolute SST. Consistently, the model shows enhanced precipitation north of this region, where the SST gradients are enhanced. However, the signal restricts to the low and mid-troposphere and does not reach the higher model levels. There is little evidence for a large-scale response to the changes in the Gulf Stream region; instead, the large scale signal is mainly controlled by the warmer background state and the AMOC slowdown and influenced by tropical SSTs. In a warmer climate the same change in SST gradient has a stronger effect on precipitation and the model produces a slightly enhanced North Atlantic storm track.

Late Oligocene decoupling of temperature and pCO2: Insights from TEX86 paleothermometry

NASA Astrophysics Data System (ADS)

O'Brien, C. L.; Pagani, M.

2016-12-01

Current paleo-proxy reconstructions for the late Oligocene ( 28-23 Ma) indicate a decoupling of temperature and pCO2. Specifically, benthic oxygen isotope data suggest either stable conditions or warming/deglaciation, while alkenone-based pCO2 estimates indicate a decline from 700 to 400 ppm. Existing sea surface temperature (SST) proxy estimates for this interval are sparse and the appearance of decoupling could be fallacious. Using late Oligocene marine sediments from a range of oceanographic and latitudinal settings, in particular Atlantic Ocean sites ODP 929A (5°N), DSDP 608 (42°N) and DSDP 516F (30°S), we are applying the TEX86 paleothermometer to provide improved constraints on late Oligocene warmth. Thought to originate mainly from planktonic, ammonia-oxidizing Thaumarchaeota, the sedimentary TEX86 signal is complicated by potential influences from additional sources and non-thermal effects (e.g., water chemistry, nutrient dynamics, growth stage and ecology). Thus, we are simultaneously testing assumptions regarding the fidelity of the TEX86 paleo-SST proxy. Our new TEX86H-SST data from Atlantic site ODP 929A indicate stable SSTs in the tropics (often reflective of global conditions) during the late Oligocene, with no reduction in SST coincident with declining pCO2 during the period 28-24 Ma. Importantly, TEX86H-SST data show a lack of coherence with latitude exemplified by similar stable SSTs, 28°C, at tropical and southern mid-latitude Atlantic sites ODP 929 and DSDP 516F, respectively. This absence of a decrease in SST with increasing site latitude suggests that additional non-thermal factors may be influencing the TEX86 signal at certain locations and/or a need for regional-based TEX86-SST calibrations. Indeed, if our tropical TEX86-SST reconstructions ( 28°C) are valid then this would imply the late Oligocene tropical Atlantic was no warmer than the Pliocene, contradicting multiple lines of evidence that the world was warmer (e.g., higher pCO2, lighter benthic δ18O values and lower ice volume). We shall critically evaluate the implications of our TEX86 data with respect to both (1) late Oligocene climate dynamics and (2) the validity of the TEX86-SST proxy across multiple late Oligocene ocean sites.

Impact of a warm core eddy on near-surface wind at Brazil-Malvinas Confluence region in high resolution simulations

NASA Astrophysics Data System (ADS)

Hackerott, J. A.; Mesquita, M. D. S.; Camargo, R. D.; Pezzi, L. P.

2014-12-01

Several studies show that near surface winds acquire anticyclonic (cyclonic) vorticity and accelerate (decelerate) when flow in the same direction as positive (negative) orientation of the Sea Surface Temperature (SST) gradient. Many of them were made over different oceanic thermal fronts in the world analyzing contrasts in SST gradients. However, still remains much uncertainty about how strong is this wind modulation, particularly on areas in need of studies and in-situ data, such as the Brazil-Malvinas Confluence Region (BMC) where intense SST gradients are found. This study brings results of the Weather Research and Forecasting (WRF) model simulations, configured with nested grids, where it is compared the influence of distinct synoptic patterns observed at BMC where three different SST patterns are imposed to WRF. These patterns are: (1) with a typical smoothed SST field, named as Control; (2) Small Eddy, which is the same as Control but adding an eddy of 1° radius and a +2°C amplitude; and (3) Intense Eddy, which is also the same as Control, but where an eddy of 1° radius and +4°C amplitude is added. The artificial imposed eddy is analogous to the SST patterns observed at BMC, with different intensities. The simulations were integrated for 76 hours using initial and lateral boundary conditions from the Global Forecast System (GFS) model with 0.5° resolution. The results showed that the wind at 10m height is influenced by the diurnal cycle of turbulence in the Marine Atmospheric Boundary Layer (MABL) modified by variations in SST. The wind magnitude changes up to 1m.s-1 over a 4/50°C.km-1 SST gradient and 0.6m.s-1 over a 2/50°C.km-1 SST gradient. This effect generates meso-scale disturbances that propagate to larger scales leading to disturbances in remote areas. Thus, the preliminary analyses are suggesting that there is an interaction between the meso and synoptic scale playing a role. Mechanisms such this one might not be captured by atmospheric global models used in low spatial resolution. Often, that is the case seen on operational models.

Assessing the applicability of the 1D flux theory to full-scale secondary settling tank design with a 2D hydrodynamic model.

PubMed

Ekama, G A; Marais, P

2004-02-01

The applicability of the one-dimensional idealized flux theory (1DFT) for the design of secondary settling tanks (SSTs) is evaluated by comparing its predicted maximum surface overflow (SOR) and solids loading (SLR) rates with that calculated with the two-dimensional computational fluid dynamics model SettlerCAD using as a basis 35 full-scale SST stress tests conducted on different SSTs with diameters from 30 to 45m and 2.25-4.1m side water depth (SWD), with and without Stamford baffles. From the simulations, a relatively consistent pattern appeared, i.e. that the 1DFT can be used for design but its predicted maximum SLR needs to be reduced by an appropriate flux rating, the magnitude of which depends mainly on SST depth and hydraulic loading rate (HLR). Simulations of the Watts et al. (Water Res. 30(9)(1996)2112) SST, with doubled SWDs and the Darvill new (4.1m) and old (2.5m) SSTs with interchanged depths, were run to confirm the sensitivity of the flux rating to depth and HLR. Simulations with and without a Stamford baffle were also performed. While the design of the internal features of the SST, such as baffling, has a marked influence on the effluent SS concentration while the SST is underloaded, these features appeared to have only a small influence on the flux rating, i.e. capacity, of the SST. Until more information is obtained, it would appear from the simulations that the flux rating of 0.80 of the 1DFT maximum SLR recommended by Ekama and Marais (Water Pollut. Control 85(1)(1986)101) remains a reasonable value to apply in the design of full-scale SSTs-for deep SSTs (4m SWD) the flux rating could be increased to 0.85 and for shallow SSTs (2.5m SWD) decreased to 0.75. It is recommended that (i) while the apparent interrelationship between SST flux rating and depth suggests some optimization of the volume of the SST, this be avoided and (ii) the depth of the SST be designed independently of the surface area as is usually the practice and once selected, the appropriate flux rating applied to the 1DFT estimate of the surface area.

Error Estimation of Pathfinder Version 5.3 SST Level 3C Using Three-way Error Analysis

NASA Astrophysics Data System (ADS)

Saha, K.; Dash, P.; Zhao, X.; Zhang, H. M.

2017-12-01

One of the essential climate variables for monitoring as well as detecting and attributing climate change, is Sea Surface Temperature (SST). A long-term record of global SSTs are available with observations obtained from ships in the early days to the more modern observation based on in-situ as well as space-based sensors (satellite/aircraft). There are inaccuracies associated with satellite derived SSTs which can be attributed to the errors associated with spacecraft navigation, sensor calibrations, sensor noise, retrieval algorithms, and leakages due to residual clouds. Thus it is important to estimate accurate errors in satellite derived SST products to have desired results in its applications.Generally for validation purposes satellite derived SST products are compared against the in-situ SSTs which have inaccuracies due to spatio/temporal inhomogeneity between in-situ and satellite measurements. A standard deviation in their difference fields usually have contributions from both satellite as well as the in-situ measurements. A real validation of any geophysical variable must require the knowledge of the "true" value of the said variable. Therefore a one-to-one comparison of satellite based SST with in-situ data does not truly provide us the real error in the satellite SST and there will be ambiguity due to errors in the in-situ measurements and their collocation differences. A Triple collocation (TC) or three-way error analysis using 3 mutually independent error-prone measurements, can be used to estimate root-mean square error (RMSE) associated with each of the measurements with high level of accuracy without treating any one system a perfectly-observed "truth". In this study we are estimating the absolute random errors associated with Pathfinder Version 5.3 Level-3C SST product Climate Data record. Along with the in-situ SST data, the third source of dataset used for this analysis is the AATSR reprocessing of climate (ARC) dataset for the corresponding period. All three SST observations are collocated, and statistics of difference between each pair is estimated. Instead of using a traditional TC analysis we have implemented the Extended Triple Collocation (ETC) approach to estimate the correlation coefficient of each measurement system w.r.t. the unknown target variable along with their RMSE.

Late Quaternary surface circulation in the east equatorial South Atlantic: Evidence from Alkenone sea surface temperatures

NASA Astrophysics Data System (ADS)

Schneider, Ralph R.; Müller, Peter J.; Ruhland, GöTz

1995-04-01

Angola Basin and Walvis Ridge records of past sea surface temperatures (SST) derived from the alkenone Uk37 index are used to reconstruct the surface circulation in the east equatorial South Atlantic for the last 200,000 years. Comparison of SST estimates from surface sediments between 5° and 20°S with modern SST data suggests that the alkenone temperatures represent annual mean values of the surface mixed layer. Alkenone-derived temperatures for the warm climatic maxima of the Holocene and the penultimate interglacial are 1 to 4°C higher than latest Holocene values. All records show glacial to interglacial differences of about 3.5°C in annual mean SST, which is about 1.5°C greater than the difference estimated by CLIMAP (1981) for the eastern Angola Basin. At the Walvis Ridge, significant SST variance is observed at all of the Earth's orbital periodicities. SST records from the Angola Basin vary predominantly at 23- and 100-kyr periodicities. For the precessional cycle, SST changes at the Walvis Ridge correspond to variations of boreal summer insolation over Africa and lead ice volume changes, suggesting that the east equatorial South Atlantic is sensitive to African monsoon intensity via trade-wind zonality. Angola Basin SST records lag those from the Walvis Ridge and the equatorial Atlantic by about 3 kyr. The comparison of Angola Basin and Walvis Ridge SST records implies that the Angola-Benguela Front (ABF) (currently at about 14-16°S) has remained fairly stationary between 12° and 20°S (the limits of our cores) during the last two glacial-interglacial cycles. The temperature contrast associated with the ABF exhibits a periodic 23-kyr variability which is coherent with changes in boreal summer insolation over Africa. These observations suggest that surface waters north of the present ABF have not directly responded to monsoon-modulated changes in the trade-wind vector, that the central field of zonally directed trades in the southern hemisphere was not shifted or extended northward by several degrees of latitude during glacials, and that a cyclonic gyre circulation has existed in the east equatorial South Atlantic over the last 200,000 years. This scenario contradicts former assumptions of glacial intensification of the Benguela Current into the eastern Angola Basin and increased coastal upwelling off Angola.

West African Monsoon dynamics in idealized simulations: the competitive roles of SST warming and CO2

NASA Astrophysics Data System (ADS)

Gaetani, Marco; Flamant, Cyrille; Hourdin, Frederic; Bastin, Sophie; Braconnot, Pascale; Bony, Sandrine

2015-04-01

The West African Monsoon (WAM) is affected by large climate variability at different timescales, from interannual to multidecadal, with strong environmental and socio-economic impacts associated to climate-related rainfall variability, especially in the Sahelian belt. State-of-the-art coupled climate models still show poor ability in correctly simulating the WAM past variability and also a large spread is observed in future climate projections. In this work, the July-to-September (JAS) WAM variability in the period 1979-2008 is studied in AMIP-like simulations (SST-forced) from CMIP5. The individual roles of global SST warming and CO2 concentration increasing are investigated through idealized experiments simulating a 4K warmer SST and a 4x CO2 concentration, respectively. Results show a dry response in Sahel to SST warming, with dryer conditions over western Sahel. On the contrary, wet conditions are observed when CO2 is increased, with the strongest response over central-eastern Sahel. The precipitation changes are associated to modifications in the regional atmospheric circulation: dry (wet) conditions are associated with reduced (increased) convergence in the lower troposphere, a southward (northward) shift of the African Easterly Jet, and a weaker (stronger) Tropical Easterly Jet. The co-variability between global SST and WAM precipitation is also investigated, highlighting a reorganization of the main co-variability modes. Namely, in the 4xCO2 simulation the influence of Tropical Pacific is dominant, while it is reduced in the 4K simulation, which also shows an increased coupling with the eastern Pacific and the Indian Ocean. The above results suggest a competitive action of SST warming and CO2 increasing on the WAM climate variability, with opposite effects on precipitation. The combination of the observed positive and negative response in precipitation, with wet conditions in central-eastern Sahel and dry conditions in western Sahel, is consistent with the future precipitation trends over West Africa resulting from CMIP5 coupled simulations. It is argued that the large spread in CMIP5 future projections may be related to the weight given to SST warming and direct CO2 effect by individual models. The capability of climate models in reproducing the SST-precipitation relationship appears to be crucial in this respect.

Inter comparison of Tropical Indian Ocean features in different ocean reanalysis products

NASA Astrophysics Data System (ADS)

Karmakar, Ananya; Parekh, Anant; Chowdary, J. S.; Gnanaseelan, C.

2017-09-01

This study makes an inter comparison of ocean state of the Tropical Indian Ocean (TIO) in different ocean reanalyses such as global ocean data assimilation system (GODAS), ensemble coupled data assimilation (ECDA), ocean reanalysis system 4 (ORAS4) and simple ocean data assimilation (SODA) with reference to the in-situ buoy observations, satellite observed sea surface temperature (SST), EN4 analysis and ocean surface current analysis real time (OSCAR). Analysis of mean state of SST and sea surface salinity (SSS) reveals that ORAS4 is better comparable with satellite observations as well as EN4 analysis, and is followed by SODA, ECDA and GODAS. The surface circulation in ORAS4 is closer to OSCAR compared to the other reanalyses. However mixed layer depth (MLD) is better simulated by SODA, followed by ECDA, ORAS4 and GODAS. Seasonal evolution of error indicates that the highest deviation in SST and MLD over the TIO exists during spring and summer in GODAS. Statistical analysis with concurrent data of EN4 for the period of 1980-2010 supports that the difference and standard deviation (variability strength) ratio for SSS and MLD is mostly greater than one. In general the strength of variability is overestimated by all the reanalyses. Further comparison with in-situ buoy observations supports that MLD errors over the equatorial Indian Ocean (EIO) and the Bay of Bengal are higher than with EN4 analysis. Overall ORAS4 displays higher correlation and lower error among all reanalyses with respect to both EN4 analysis and buoy observations. Major issues in the reanalyses are the underestimation of upper ocean stability in the TIO, underestimation of surface current in the EIO, overestimation of vertical shear of current and improper variability in different oceanic variables. To improve the skill of reanalyses over the TIO, salinity vertical structure and upper ocean circulation need to be better represented in reanalyses.

Ocean eddies and climate predictability

NASA Astrophysics Data System (ADS)

Kirtman, Ben P.; Perlin, Natalie; Siqueira, Leo

2017-12-01

A suite of coupled climate model simulations and experiments are used to examine how resolved mesoscale ocean features affect aspects of climate variability, air-sea interactions, and predictability. In combination with control simulations, experiments with the interactive ensemble coupling strategy are used to further amplify the role of the oceanic mesoscale field and the associated air-sea feedbacks and predictability. The basic intent of the interactive ensemble coupling strategy is to reduce the atmospheric noise at the air-sea interface, allowing an assessment of how noise affects the variability, and in this case, it is also used to diagnose predictability from the perspective of signal-to-noise ratios. The climate variability is assessed from the perspective of sea surface temperature (SST) variance ratios, and it is shown that, unsurprisingly, mesoscale variability significantly increases SST variance. Perhaps surprising is the fact that the presence of mesoscale ocean features even further enhances the SST variance in the interactive ensemble simulation beyond what would be expected from simple linear arguments. Changes in the air-sea coupling between simulations are assessed using pointwise convective rainfall-SST and convective rainfall-SST tendency correlations and again emphasize how the oceanic mesoscale alters the local association between convective rainfall and SST. Understanding the possible relationships between the SST-forced signal and the weather noise is critically important in climate predictability. We use the interactive ensemble simulations to diagnose this relationship, and we find that the presence of mesoscale ocean features significantly enhances this link particularly in ocean eddy rich regions. Finally, we use signal-to-noise ratios to show that the ocean mesoscale activity increases model estimated predictability in terms of convective precipitation and atmospheric upper tropospheric circulation.

Adrenal suppression in patients taking inhaled glucocorticoids is highly prevalent and management can be guided by morning cortisol

PubMed Central

Woods, Conor P; Argese, Nicola; Chapman, Matthew; Boot, Christopher; Webster, Rachel; Dabhi, Vijay; Grossman, Ashley B; Toogood, Andrew A; Arlt, Wiebke; Stewart, Paul M; Crowley, Rachel K; Tomlinson, Jeremy W

2015-01-01

Context Up to 3% of US and UK populations are prescribed glucocorticoids (GC). Suppression of the hypothalamo–pituitary–adrenal axis with the potential risk of adrenal crisis is a recognized complication of therapy. The 250 μg short Synacthen stimulation test (SST) is the most commonly used dynamic assessment to diagnose adrenal insufficiency. There are challenges to the use of the SST in routine clinical practice, including both the staff and time constraints and a significant recent increase in Synacthen cost. Methods We performed a retrospective analysis to determine the prevalence of adrenal suppression due to prescribed GCs and the utility of a morning serum cortisol for rapid assessment of adrenal reserve in the routine clinical setting. Results In total, 2773 patients underwent 3603 SSTs in a large secondary/tertiary centre between 2008 and 2013 and 17.9% (n=496) failed the SST. Of 404 patients taking oral, topical, intranasal or inhaled GC therapy for non-endocrine conditions, 33.2% (n=134) had a subnormal SST response. In patients taking inhaled GCs without additional GC therapy, 20.5% (34/166) failed an SST and suppression of adrenal function increased in a dose-dependent fashion. Using receiver operating characteristic curve analysis in patients currently taking inhaled GCs, a basal cortisol ≥348 nmol/l provided 100% specificity for passing the SST; a cortisol value <34 nmol/l had 100% sensitivity for SST failure. Using these cut-offs, 50% (n=83) of SSTs performed on patients prescribed inhaled GCs were unnecessary. Conclusion Adrenal suppression due to GC treatment, particularly inhaled GCs, is common. A basal serum cortisol concentration has utility in helping determine which patients should undergo dynamic assessment of adrenal function. PMID:26294794

Saturated Salt Solution Method: A Useful Cadaver Embalming for Surgical Skills Training

PubMed Central

Hayashi, Shogo; Homma, Hiroshi; Naito, Munekazu; Oda, Jun; Nishiyama, Takahisa; Kawamoto, Atsuo; Kawata, Shinichi; Sato, Norio; Fukuhara, Tomomi; Taguchi, Hirokazu; Mashiko, Kazuki; Azuhata, Takeo; Ito, Masayuki; Kawai, Kentaro; Suzuki, Tomoya; Nishizawa, Yuji; Araki, Jun; Matsuno, Naoto; Shirai, Takayuki; Qu, Ning; Hatayama, Naoyuki; Hirai, Shuichi; Fukui, Hidekimi; Ohseto, Kiyoshige; Yukioka, Tetsuo; Itoh, Masahiro

2014-01-01

Abstract This article evaluates the suitability of cadavers embalmed by the saturated salt solution (SSS) method for surgical skills training (SST). SST courses using cadavers have been performed to advance a surgeon's techniques without any risk to patients. One important factor for improving SST is the suitability of specimens, which depends on the embalming method. In addition, the infectious risk and cost involved in using cadavers are problems that need to be solved. Six cadavers were embalmed by 3 methods: formalin solution, Thiel solution (TS), and SSS methods. Bacterial and fungal culture tests and measurement of ranges of motion were conducted for each cadaver. Fourteen surgeons evaluated the 3 embalming methods and 9 SST instructors (7 trauma surgeons and 2 orthopedists) operated the cadavers by 21 procedures. In addition, ultrasonography, central venous catheterization, and incision with cauterization followed by autosuture stapling were performed in some cadavers. The SSS method had a sufficient antibiotic effect and produced cadavers with flexible joints and a high tissue quality suitable for SST. The surgeons evaluated the cadavers embalmed by the SSS method to be highly equal to those embalmed by the TS method. Ultrasound images were clear in the cadavers embalmed by both the methods. Central venous catheterization could be performed in a cadaver embalmed by the SSS method and then be affirmed by x-ray. Lungs and intestines could be incised with cauterization and autosuture stapling in the cadavers embalmed by TS and SSS methods. Cadavers embalmed by the SSS method are sufficiently useful for SST. This method is simple, carries a low infectious risk, and is relatively of low cost, enabling a wider use of cadavers for SST. PMID:25501070

A Reconstruction of Subtropical Western North Pacific SST Variability Back to 1578, Based on a Porites Coral Sr/Ca Record from the Northern Ryukyus, Japan

NASA Astrophysics Data System (ADS)

Kawakubo, Y.; Alibert, C.; Yokoyama, Y.

2017-12-01

We present a seasonal reconstruction of sea surface temperature (SST) from 1578 to 2008, based on a Porites coral Sr/Ca record from the northern Ryukyus, within the Kuroshio southern recirculation gyre. Interannual SST anomalies are generally 0.5°C, making Sr/Ca-derived SST reconstructions a challenging task. Replicate measurements along adjacent coral growth axes, enabled by the laser ablation inductively coupled plasma mass spectrometry technique used here, give evidence of rather large uncertainties. Nonetheless, derived winter SST anomalies are significantly correlated with the Western Pacific atmospheric pattern which has a dominant influence on winter temperature in East Asia. Annual mean SSTs show interdecadal variations, notably cold intervals between 1670 and 1700 during the Maunder Minimum (MM) and between 1766 and 1788 characterized by a negative phase of the North Atlantic Oscillation. Cold summers in 1783 and 1784 coincide with the long-lasting Laki eruption that had a profound impact on the Northern Hemisphere climate, including the severe "Tenmei" famine in Japan. The decades between 1855 and 1900 are significantly cooler than the first half of the twentieth century, while those between 1700 and 1765, following the MM, are warmer than average. SST variability in the Ryukyus is only marginally influenced by the Pacific Decadal Oscillation, so that external forcing remains the main driver of low-frequency temperature changes. However, the close connection between the Kuroshio extension (KE) and its recirculation gyre suggests that decadal SST anomalies associated with the KE front also impact the Ryukyus, and there is a possible additional role for feedback of the Kuroshio-Oyashio variability to the large-scale atmosphere at decadal timescale.

An Assessment of the SST Simulation Using the Climate Forecast System Coupled to the SSiB Surface Model

NASA Astrophysics Data System (ADS)

Wang, Y.; Xue, Y.; Huang, B.; Lee, J.; De Sales, F.

2016-12-01

A long term simulation has been conducted using the Climate Forecast System (CFSv2) coupled to the SSiB-2 land model, which consists of the Global Forecast System atmospheric model (GFS) and the Modular Ocean model - version 4 (MOM4) as the ocean component. This study evaluates the model's performance in simulating sea surface temperature (SST) mean state, trend, and inter-annual and decadal variabilities. The model is able to produce the reasonable spatial distribution of the SST climatology; however, it has prominent large scale biases. In the middle latitude of the Northern Hemisphere, major cold biases is close to the warm side of the large SST gradients, which may be associated with the weaker Kuroshio and Gulf Stream extensions that diffuse the SST gradient. IN addition, warm biases extend along the west coast of the North America continent to the high latitude, which may be related with excessive Ekman down-welling and solar radiation fluxes reaching to the surface due to the lack of cloud there. Warm biases also exist over the tropical cold tough areas in the Pacific and Atlantic. The global SST trend and interannual variations are well captured except for that in the south Hemisphere after year 2000, which is mainly contributed by the bias from the southern Pacific Ocean. Although the model fails to accurately produce ENSO events in proper years, it does reproduce the ENSO frequency well; they are skewed toward more warm events after 1990. The model also shows ability in SST decadal variation, such as the so-called inter-decadal Pacific oscillation (IPO); however, its phases seem to go reversely compared with the observation.

Ocean eddies and climate predictability.

PubMed

Kirtman, Ben P; Perlin, Natalie; Siqueira, Leo

2017-12-01

A suite of coupled climate model simulations and experiments are used to examine how resolved mesoscale ocean features affect aspects of climate variability, air-sea interactions, and predictability. In combination with control simulations, experiments with the interactive ensemble coupling strategy are used to further amplify the role of the oceanic mesoscale field and the associated air-sea feedbacks and predictability. The basic intent of the interactive ensemble coupling strategy is to reduce the atmospheric noise at the air-sea interface, allowing an assessment of how noise affects the variability, and in this case, it is also used to diagnose predictability from the perspective of signal-to-noise ratios. The climate variability is assessed from the perspective of sea surface temperature (SST) variance ratios, and it is shown that, unsurprisingly, mesoscale variability significantly increases SST variance. Perhaps surprising is the fact that the presence of mesoscale ocean features even further enhances the SST variance in the interactive ensemble simulation beyond what would be expected from simple linear arguments. Changes in the air-sea coupling between simulations are assessed using pointwise convective rainfall-SST and convective rainfall-SST tendency correlations and again emphasize how the oceanic mesoscale alters the local association between convective rainfall and SST. Understanding the possible relationships between the SST-forced signal and the weather noise is critically important in climate predictability. We use the interactive ensemble simulations to diagnose this relationship, and we find that the presence of mesoscale ocean features significantly enhances this link particularly in ocean eddy rich regions. Finally, we use signal-to-noise ratios to show that the ocean mesoscale activity increases model estimated predictability in terms of convective precipitation and atmospheric upper tropospheric circulation.

Impact of tropical Atlantic sea-surface temperature biases on the simulated atmospheric circulation and precipitation over the Atlantic region: An ECHAM6 model study

NASA Astrophysics Data System (ADS)

Eichhorn, Astrid; Bader, Jürgen

2017-09-01

As many coupled atmosphere-ocean general circulation models, the coupled Earth System Model developed at the Max Planck Institute for Meteorology suffers from severe sea-surface temperature (SST) biases in the tropical Atlantic. We performed a set of SST sensitivity experiments with its atmospheric model component ECHAM6 to understand the impact of tropical Atlantic SST biases on atmospheric circulation and precipitation. The model was forced by a climatology of observed global SSTs to focus on simulated seasonal and annual mean state climate. Through the superposition of varying tropical Atlantic bias patterns extracted from the MPI-ESM on top of the control field, this study investigates the relevance of the seasonal variation and spatial structure of tropical Atlantic biases for the simulated response. Results show that the position and structure of the Intertropical Convergence Zone (ITCZ) across the Atlantic is significantly affected, exhibiting a dynamically forced shift of annual mean precipitation maximum to the east of the Atlantic basin as well as a southward shift of the oceanic rain belt. The SST-induced changes in the ITCZ in turn affect seasonal rainfall over adjacent continents. However not only the ITCZ position but also other effects arising from biases in tropical Atlantic SSTs, e.g. variations in the wind field, change the simulation of precipitation over land. The seasonal variation and spatial pattern of tropical Atlantic SST biases turns out to be crucial for the simulated atmospheric response and is essential for analyzing the contribution of SST biases to coupled model mean state biases. Our experiments show that MPI-ESM mean-state biases in the Atlantic sector are mainly driven by SST biases in the tropical Atlantic while teleconnections from other basins seem to play a minor role.

Understanding the predictability of seasonal precipitation over northeast Brazil

NASA Astrophysics Data System (ADS)

Misra, Vasubandhu

2006-05-01

Using multiple long-term simulations of the Center for Ocean-Land-Atmosphere Studies (COLA) atmospheric general circulation model (AGCM) forced with observed sea surface temperature (SST), it is shown that the model has high skill in simulating the February-March-April (FMA) rainy season over northeast Brazil (Nordeste). Separate sensitivity experiments conducted with the same model that entails suppression of all variability except for the climatological annual cycle in SST over the Pacific and Atlantic Oceans reveal that this skill over Nordeste is sensitive to SST anomalies in the tropical Atlantic Ocean. However, the spatial pattern of SST anomalies in the tropical Atlantic Ocean that correlate with FMA Nordeste rainfall are in fact a manifestation of El Niño Southern Oscillation (ENSO) phenomenon in the Pacific Ocean. This study also analyzes the failure of the COLA AGCM in capturing the correct FMA precipitation anomalies over Nordeste in several years of the simulation. It is found that this failure occurs when the SST anomalies over the northern tropical Atlantic Ocean are large and not significantly correlated with contemporaneous SST anomalies over the eastern Pacific Ocean. In two of the relatively large ENSO years when the model failed to capture the correct signal of the interannual variability of precipitation over Nordeste, it was found that the meridional gradient of SST anomalies over the tropical Atlantic Ocean was inconsistent with the canonical development of ENSO. The analysis of the probabilistic skill of the model revealed that it has more skill in predicting flood years than drought. Furthermore, the model has no skill in predicting normal seasons. These model features are consistent with the model systematic errors.

Modeling of Solid State Transformer for the FREEDM System Demonstration

NASA Astrophysics Data System (ADS)

Jiang, Youyuan

The Solid State Transformer (SST) is an essential component in the FREEDM system. This research focuses on the modeling of the SST and the controller hardware in the loop (CHIL) implementation of the SST for the support of the FREEDM system demonstration. The energy based control strategy for a three-stage SST is analyzed and applied. A simplified average model of the three-stage SST that is suitable for simulation in real time digital simulator (RTDS) has been developed in this study. The model is also useful for general time-domain power system analysis and simulation. The proposed simplified av-erage model has been validated in MATLAB and PLECS. The accuracy of the model has been verified through comparison with the cycle-by-cycle average (CCA) model and de-tailed switching model. These models are also implemented in PSCAD, and a special strategy to implement the phase shift modulation has been proposed to enable the switching model simulation in PSCAD. The implementation of the CHIL test environment of the SST in RTDS is described in this report. The parameter setup of the model has been discussed in detail. One of the dif-ficulties is the choice of the damping factor, which is revealed in this paper. Also the grounding of the system has large impact on the RTDS simulation. Another problem is that the performance of the system is highly dependent on the switch parameters such as voltage and current ratings. Finally, the functionalities of the SST have been realized on the platform. The distributed energy storage interface power injection and reverse power flow have been validated. Some limitations are noticed and discussed through the simulation on RTDS.

Atmosphere-Ocean Variations in the Indo-Pacific Sector during ENSO Episodes.

NASA Astrophysics Data System (ADS)

Lau, Ngar-Cheung; Nath, Mary Jo

2003-01-01

The influences of El Niño-Southern Oscillation (ENSO) events on air-sea interaction in the Indian-western Pacific (IWP) Oceans have been investigated using a general circulation model. Observed monthly sea surface temperature (SST) variations in the deep tropical eastern/central Pacific (DTEP) have been inserted in the lower boundary of this model through the 1950-99 period. At all maritime grid points outside of DTEP, the model atmosphere has been coupled with an oceanic mixed layer model with variable depth. Altogether 16 independent model runs have been conducted.Composite analysis of selected ENSO episodes illustrates that the prescribed SST anomalies in DTEP affect the surface atmospheric circulation and precipitation patterns in IWP through displacements of the near-equatorial Walker circulation and generation of Rossby wave modes in the subtropics. Such atmospheric responses modulate the surface fluxes as well as the oceanic mixed layer depth, and thereby establish a well-defined SST anomaly pattern in the IWP sector several months after the peak in ENSO forcing in DTEP. In most parts of the IWP region, the net SST tendency induced by atmospheric changes has the same polarity as the local composite SST anomaly, thus indicating that the atmospheric forcing acts to reinforce the underlying SST signal.By analyzing the output from a suite of auxiliary experiments, it is demonstrated that the SST perturbations in IWP (which are primarily generated by ENSO-related atmospheric changes) can, in turn, exert notable influences on the atmospheric conditions over that region. This feedback mechanism also plays an important role in the eastward migration of the subtropical anticyclones over the western Pacific in both hemispheres.

Is the Simple Shoulder Test a valid outcome instrument for shoulder arthroplasty?

PubMed

Hsu, Jason E; Russ, Stacy M; Somerson, Jeremy S; Tang, Anna; Warme, Winston J; Matsen, Frederick A

2017-10-01

The Simple Shoulder Test (SST) is a brief, inexpensive, and widely used patient-reported outcome tool, but it has not been rigorously evaluated for patients having shoulder arthroplasty. The goal of this study was to rigorously evaluate the validity of the SST for outcome assessment in shoulder arthroplasty using a systematic review of the literature and an analysis of its properties in a series of 408 surgical cases. SST scores, 36-Item Short Form Health Survey scores, and satisfaction scores were collected preoperatively and 2 years postoperatively. Responsiveness was assessed by comparing preoperative and 2-year postoperative scores. Criterion validity was determined by correlating the SST with the 36-Item Short Form Health Survey. Construct validity was tested through 5 clinical hypotheses regarding satisfaction, comorbidities, insurance status, previous failed surgery, and narcotic use. Scores after arthroplasty improved from 3.9 ± 2.8 to 10.2 ± 2.3 (P < .001). The change in SST correlated strongly with patient satisfaction (P < .001). The SST had large Cohen's d effect sizes and standardized response means. Criterion validity was supported by significant differences between satisfied and unsatisfied patients, those with more severe and less severe comorbidities, those with workers' compensation or Medicaid and other types of insurance, those with and without previous failed shoulder surgery, and those taking and those not taking narcotic pain medication before surgery (P < .005). These data combined with a systematic review of the literature demonstrate that the SST is a valid and responsive patient-reported outcome measure for assessing the outcomes of shoulder arthroplasty. Copyright © 2017 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.

Sensitivity of Asian Summer Monsoon precipitation to tropical sea surface temperature anomalies

NASA Astrophysics Data System (ADS)

Fan, Lei; Shin, Sang-Ik; Liu, Zhengyu; Liu, Qinyu

2016-10-01

Sensitivity of Asian Summer Monsoon (ASM) precipitation to tropical sea surface temperature (SST) anomalies was estimated from ensemble simulations of two atmospheric general circulation models (GCMs) with an array of idealized SST anomaly patch prescriptions. Consistent sensitivity patterns were obtained in both models. Sensitivity of Indian Summer Monsoon (ISM) precipitation to cooling in the East Pacific was much weaker than to that of the same magnitude in the local Indian-western Pacific, over which a meridional pattern of warm north and cold south was most instrumental in increasing ISM precipitation. This indicates that the strength of the ENSO-ISM relationship is due to the large-amplitude East Pacific SST anomaly rather than its sensitivity value. Sensitivity of the East Asian Summer Monsoon (EASM), represented by the Yangtze-Huai River Valley (YHRV, also known as the meiyu-baiu front) precipitation, is non-uniform across the Indian Ocean basin. YHRV precipitation was most sensitive to warm SST anomalies over the northern Indian Ocean and the South China Sea, whereas the southern Indian Ocean had the opposite effect. This implies that the strengthened EASM in the post-Niño year is attributable mainly to warming of the northern Indian Ocean. The corresponding physical links between these SST anomaly patterns and ASM precipitation were also discussed. The relevance of sensitivity maps was justified by the high correlation between sensitivity-map-based reconstructed time series using observed SST anomaly patterns and actual precipitation series derived from ensemble-mean atmospheric GCM runs with time-varying global SST prescriptions during the same period. The correlation results indicated that sensitivity maps derived from patch experiments were far superior to those based on regression methods.

Real-time forecasting at weekly timescales of the SST and SLA of the Ligurian Sea with a satellite-based ocean forecasting (SOFT) system

NASA Astrophysics Data System (ADS)

ÁLvarez, A.; Orfila, A.; Tintoré, J.

2004-03-01

Satellites are the only systems able to provide continuous information on the spatiotemporal variability of vast areas of the ocean. Relatively long-term time series of satellite data are nowadays available. These spatiotemporal time series of satellite observations can be employed to build empirical models, called satellite-based ocean forecasting (SOFT) systems, to forecast certain aspects of future ocean states. SOFT systems can predict satellite-observed fields at different timescales. The forecast skill of SOFT systems forecasting the sea surface temperature (SST) at monthly timescales has been extensively explored in previous works. In this work we study the performance of two SOFT systems forecasting, respectively, the SST and sea level anomaly (SLA) at weekly timescales, that is, providing forecasts of the weekly averaged SST and SLA fields with 1 week in advance. The SOFT systems were implemented in the Ligurian Sea (Western Mediterranean Sea). Predictions from the SOFT systems are compared with observations and with the predictions obtained from persistence models. Results indicate that the SOFT system forecasting the SST field is always superior in terms of predictability to persistence. Minimum prediction errors in the SST are obtained during winter and spring seasons. On the other hand, the biggest differences between the performance of SOFT and persistence models are found during summer and autumn. These changes in the predictability are explained on the basis of the particular variability of the SST field in the Ligurian Sea. Concerning the SLA field, no improvements with respect to persistence have been found for the SOFT system forecasting the SLA field.

Influence of Transient Atmospheric Circulation on the Surface Heating of the Pacific Warm Pool

NASA Technical Reports Server (NTRS)

Chou, Ming-Dah; Chou, Shu-Hsien; Chan, Pui-King

2003-01-01

Analyses of data on clouds, winds, and surface heat fluxes show that the transient behavior of basin-wide large-scale circulation has a significant influence on the warm pool sea surface temperature (SST). Trade winds converge to regions of the highest SST in the equatorial western Pacific. These regions have the largest cloud cover and smallest wind speed. Both surface solar heating and evaporative cooling are weak. The reduced evaporative cooling due to weakened winds exceeds the reduced solar heating due to enhanced cloudiness. The result is a maximum surface heating in the strong convective and high SST regions. Data also show that the maximum surface heating in strong convective regions is interrupted by transient atmospheric and oceanic circulation. Due to the seasonal variation of the insolation at the top of the atmosphere, trade winds and clouds also experience seasonal variations. Regions of high SST and low-level convergence follow the Sun, where the surface heating is a maximum. As the Sun moves away from a convective region, the strong trade winds set in, and the evaporative cooling enhances, resulting in a net cooling of the surface. During an El Nino, the maximum SST and convective region shifts eastward from the maritime continent to the equatorial central Pacific. Following the eastward shift of the maximum SST, the region of maximum cloudiness and surface heating also shift eastward. As the atmospheric and oceanic circulation returns to normal situations, the trade winds increase and the surface heating decreases. We conclude that the evaporative cooling associated with the seasonal and interannual variations of trade winds is one of the major factors that modulate the SST distribution of the Pacific warm pool.

Twentieth century sea surface temperature and salinity variations at Timor inferred from paired coral δ18O and Sr/Ca measurements

NASA Astrophysics Data System (ADS)

Cahyarini, Sri Yudawati; Pfeiffer, Miriam; Nurhati, Intan Suci; Aldrian, Edvin; Dullo, Wolf-Christian; Hetzinger, Steffen

2014-07-01

The Indonesian Throughflow (ITF), which represents the global ocean circulation connecting the Pacific Warm Pool to the Indian Ocean, strongly influences the Indo-Pacific climate. ITF monitoring since the late 1990s using mooring buoys have provided insights on seasonal and interannual time scales. However, the absence of longer records limits our perspective on its evolution over the past century. Here, we present sea surface temperature (SST) and salinity (SSS) proxy records from Timor Island located at the ITF exit passage via paired coral δ18O and Sr/Ca measurements spanning the period 1914-2004. These high-resolution proxy based climate data of the last century highlights improvements and cautions when interpreting paleoclimate records of the Indonesian region. If the seasonality of SST and SSS is not perfectly in phase, the application of coral Sr/Ca thermometry improves SST reconstructions compared to estimates based on coral δ18O only. Our records also underline the importance of ocean advection besides rainfall on local SSS in the region. Although the El Niño/Southern Oscillation (ENSO) causes larger anomalies relative to the Indian Ocean Dipole (IOD), Timor coral-based SST and SSS records robustly correlate with IOD on interannual time scales, whereas ENSO only modifies Timor SST. Similarly, Timor SST and SSS are strongly linked to Indian Ocean decadal-scale variations that appear to lead Timor oceanographic conditions by about 1.6-2 years. Our study sheds new light on the complex signatures of Indo-Pacific climate modes on SST and SSS dynamics of the ITF. This article was corrected on 8 AUG 2014. See the end of the full text for details.

Effects of the diurnal cycle in solar radiation on the tropical Indian Ocean mixed layer variability during wintertime Madden-Julian Oscillations

NASA Astrophysics Data System (ADS)

Li, Yuanlong; Han, Weiqing; Shinoda, Toshiaki; Wang, Chunzai; Lien, Ren-Chieh; Moum, James N.; Wang, Jih-Wang

2013-10-01

The effects of solar radiation diurnal cycle on intraseasonal mixed layer variability in the tropical Indian Ocean during boreal wintertime Madden-Julian Oscillation (MJO) events are examined using the HYbrid Coordinate Ocean Model. Two parallel experiments, the main run and the experimental run, are performed for the period of 2005-2011 with daily atmospheric forcing except that an idealized hourly shortwave radiation diurnal cycle is included in the main run. The results show that the diurnal cycle of solar radiation generally warms the Indian Ocean sea surface temperature (SST) north of 10°S, particularly during the calm phase of the MJO when sea surface wind is weak, mixed layer is thin, and the SST diurnal cycle amplitude (dSST) is large. The diurnal cycle enhances the MJO-forced intraseasonal SST variability by about 20% in key regions like the Seychelles-Chagos Thermocline Ridge (SCTR; 55°-70°E, 12°-4°S) and the central equatorial Indian Ocean (CEIO; 65°-95°E, 3°S-3°N) primarily through nonlinear rectification. The model also well reproduced the upper-ocean variations monitored by the CINDY/DYNAMO field campaign between September-November 2011. During this period, dSST reaches 0.7°C in the CEIO region, and intraseasonal SST variability is significantly amplified. In the SCTR region where mean easterly winds are strong during this period, diurnal SST variation and its impact on intraseasonal ocean variability are much weaker. In both regions, the diurnal cycle also has a large impact on the upward surface turbulent heat flux QT and induces diurnal variation of QT with a peak-to-peak difference of O(10 W m-2).

Revisiting the Processes That Determine Wintertime Intraseasonal SST Variability in the Thermocline Ridge of the Tropical South Indian Ocean

NASA Astrophysics Data System (ADS)

Han, W.; Li, Y.; Shinoda, T.; Wang, C.; Ravichandran, M.; Wang, J. W.

2014-12-01

Intraseasonal sea surface temperature (SST) variability over the Seychelles-Chagos thermocline ridge (SCTR) induced by boreal wintertime Madden-Julian oscillations (MJOs) is investigated by performing a series of OGCM experiments with improved model configuration and the recently available high quality satellite forcing fields. The impact of the ocean interannual variation of the thermocline depth -represented by the depth of 20C isotherm (D20) - in the SCTR is also assessed. The OGCM main run solution agrees well with the observations. The results show that for the 2001-2011 period, surface shortwave radiation (SWR), turbulent heat fluxes associated with wind speed, and wind stress-driven ocean dynamical processes are all important in causing the MJO-related intraseasonal SST variability in the SCTR region. Overall, forcing by SWR contributes ~31%, and forcing by winds (via both surface turbulent heat flux and ocean dynamics) contributes ~62%. The contribution of turbulent heat flux associated with wind speed is ~39% and that of wind-stress driven ocean dynamics is ~23%. The contribution of ocean dynamics, however, is considerably larger during strong ("prime") MJO events under "strong" thermocline condition. The overall effect of interannual variability of D20 on intraseasonal SST during 2001-2011 is significant in the eastern part of the SCTR (70E-85E), where the intraseasonal SST amplitudes are strengthened by about 20%. In general, a shallower/deeper SCTR favors larger/smaller SST responses to the MJO forcing. In the eastern SCTR, both the heat flux forcing and entrainment are greatly amplified under the strong SCTR condition, but only slightly suppressed under the weak SCTR condition, leading to an overall strengthening effect on intraseasonal SST variability.

Seasonal sea surface cooling in the equatorial Pacific cold tongue controlled by ocean mixing.

PubMed

Moum, James N; Perlin, Alexander; Nash, Jonathan D; McPhaden, Michael J

2013-08-01

Sea surface temperature (SST) is a critical control on the atmosphere, and numerical models of atmosphere-ocean circulation emphasize its accurate prediction. Yet many models demonstrate large, systematic biases in simulated SST in the equatorial 'cold tongues' (expansive regions of net heat uptake from the atmosphere) of the Atlantic and Pacific oceans, particularly with regard to a central but little-understood feature of tropical oceans: a strong seasonal cycle. The biases may be related to the inability of models to constrain turbulent mixing realistically, given that turbulent mixing, combined with seasonal variations in atmospheric heating, determines SST. In temperate oceans, the seasonal SST cycle is clearly related to varying solar heating; in the tropics, however, SSTs vary seasonally in the absence of similar variations in solar inputs. Turbulent mixing has long been a likely explanation, but firm, long-term observational evidence has been absent. Here we show the existence of a distinctive seasonal cycle of subsurface cooling via mixing in the equatorial Pacific cold tongue, using multi-year measurements of turbulence in the ocean. In boreal spring, SST rises by 2 kelvin when heating of the upper ocean by the atmosphere exceeds cooling by mixing from below. In boreal summer, SST decreases because cooling from below exceeds heating from above. When the effects of lateral advection are considered, the magnitude of summer cooling via mixing (4 kelvin per month) is equivalent to that required to counter the heating terms. These results provide quantitative assessment of how mixing varies on timescales longer than a few weeks, clearly showing its controlling influence on seasonal cooling of SST in a critical oceanic regime.