KSC-06pd0446

NASA Image and Video Library

2006-02-15

VANDENBERG AIR FORCE BASE, CALIF. - Inside Orbital Sciences’ Building 1555 at Vandenberg Air Force Base in California, workers adjust the first half of the fairing around the Space Technology 5 (ST5) spacecraft. The ST5, which contains three microsatellites with miniaturized redundant components and technologies, is mated to its launch vehicle, Orbital Sciences' Pegasus XL. Each of the ST5 microsatellites will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. Launch of ST5 and the Pegasus XL will be from underneath the belly of an L-1011 carrier aircraft on March 14 from Vandenberg Air Force Base.

Solar Sail Roadmap Mission GN and C Challenges

NASA Technical Reports Server (NTRS)

Heaton, Andrew F.

2005-01-01

The NASA In-Space Propulsion program is funding development work for solar sails to enhance future scientific opportunities. Key to this effort are scientific solar sail roadmap missions identified by peer review. The two near-term missions of interest are L1 Diamond and Solar Polar Imager. Additionally, the New Millennium Program is sponsoring the Space Technology 9 (ST9) demonstration mission. Solar sails are one of five technologies competing for the ST9 flight demonstration. Two candidate solar sail missions have been identified for a potential ST9 flight. All the roadmap missions and candidate flight demonstration missions face various GN&C challenges. A variety of efforts are underway to address these challenges. These include control actuator design and testing, low thrust optimization studies, attitude control system design and modeling, control-structure interaction studies, trajectory control design, and solar radiation pressure model development. Here we survey the various efforts underway and identify a few of specific recent interest and focus.

The New Millenium Program ST-5 Mission: Nanosatellite Constellation Trailblazer

NASA Technical Reports Server (NTRS)

Slavin, James A.

1999-01-01

NASA's New Millenium Program has recently selected the Nanosatellite Constellation Trailblazer (NCT) as its fifth mission (ST-5). NCT will consist of 3 small, very capable and highly autonomous satellites which will be operated as a single "constellation" with minimal ground operations support. Each spacecraft will be approximately 40 cm in diameter by 20 cm in height and weigh only 20 kg. These small satellites will incorporate 8 new technologies essential to the further miniaturization of space science spacecraft which need space flight validation. In this talk we will describe in greater detail the NCT mission concept and goals, the exciting new technologies it will validate, and the role of miniaturized particles and fields sensors in this project. Finally, NCT's pathfinder function for such future NASA missions as Magnetotail Constellation and Inner Magnetosphere Constellation will be discussed.

A Study of Learning Curve Impact on Three Identical Small Spacecraft

NASA Technical Reports Server (NTRS)

Chen, Guangming; McLennan, Douglas D.

2003-01-01

With an eye to the future strategic needs of NASA, the New Millennium Program is funding the Space Technology 5 (ST-5) project to address the future needs in the area of small satellites in constellation missions. The ST-5 project, being developed at Goddard Space Flight Center, involves the development and simultaneous launch of three small, 20-kilogram-class spacecraft. ST-5 is only a test drive and future NASA science missions may call for fleets of spacecraft containing tens of smart and capable satellites in an intelligent constellation. The objective of ST-5 project is to develop three such pioneering small spacecraft for flight validation of several critical new technologies. The ST-5 project team at Goddard Space Flight Center has completed the spacecraft design, is now building and testing the three flight units. The launch readiness date (LRD) is in December 2005. A critical part of ST-5 mission is to prove that it is possible to build these small but capable spacecraft with recurring cost low enough to make future NASA s multi- spacecraft constellation missions viable from a cost standpoint.

Space Technology 5 Launch and Operations

NASA Technical Reports Server (NTRS)

O'Donnell, James R.; Concha, Marco A.; Morrissey, James R.; Placanica, Samuel J.; Russo, Angela M.; Tsai, Dean C.

2007-01-01

The three spacecraft that made up the Space Technology 5 (ST5) mission were successfully launched and deployed from their Pegasus launch vehicle on March 22, 2006. Final contact with the spacecraft occurred on June 30, 2006, with all Level 1 requirements met. By the end of the mission, all ST5 technologies had been validated, all on-board attitude control system (ACS) modes had been successfully demonstrated, and the desired constellation configurations had been achieved to demonstrate the ability of small spacecraft to take quality science measurements, However, during those 100 days (ST5 was planned to be a 90-day mission), there were a number of anomalies that made achieving the mission goals very challenging. This paper will discuss: the chronology of the ST5 launch and early operations, work performed to diagnose and work-around a sun sensor anomaly, spacecraft tests devised to demonstrate correct operation of all onboard ACS modes, the maneuver plan performed to achieve the desired constellation, investigations performed by members of the ST5 GN&C and Science teams of an anomalous spin down condition, and the end-of-life orbit and passivating operations performed on the three spacecraft.

KSC-06pd0449

NASA Image and Video Library

2006-02-16

VANDENBERG AIR FORCE BASE, CALIF. - Inside Orbital Sciences’ Building 1555 at Vandenberg Air Force Base in California, workers check the placement of the second half of the fairing around the Space Technology 5 (ST5) spacecraft. The ST5, which contains three microsatellites with miniaturized redundant components and technologies, is mated to its launch vehicle, Orbital Sciences' Pegasus XL. Each of the ST5 microsatellites will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. Launch of ST5 and the Pegasus XL will be from underneath the belly of an L-1011 carrier aircraft on March 14 from Vandenberg Air Force Base.

KSC-06pd0554

NASA Image and Video Library

2006-03-10

VANDENBERG AIR FORCE BASE, CALIF. - Workers prepare to transport the Space Technology 5 (ST5) spacecraft from Orbital Sciences’ Building 1555 at Vandenberg Air Force Base in California to the L-1011 carrier aircraft in position on the ramp adjacent to the Vandenberg runway. The ST5, which contains three microsatellites with miniaturized redundant components and technologies, is mated to its launch vehicle, Orbital Sciences' Pegasus XL. Each of the ST5 microsatellites will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. Launch of ST5 and the Pegasus XL will be from underneath the belly of an L-1011 carrier aircraft from Vandenberg Air Force Base.

KSC-06pd0448

NASA Image and Video Library

2006-02-16

VANDENBERG AIR FORCE BASE, CALIF. - Inside Orbital Sciences’ Building 1555 at Vandenberg Air Force Base in California, workers position the second half of the fairing into place around the Space Technology 5 (ST5) spacecraft. The ST5, which contains three microsatellites with miniaturized redundant components and technologies, is mated to its launch vehicle, Orbital Sciences' Pegasus XL. Each of the ST5 microsatellites will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. Launch of ST5 and the Pegasus XL will be from underneath the belly of an L-1011 carrier aircraft on March 14 from Vandenberg Air Force Base.

KSC-06pd0447

NASA Image and Video Library

2006-02-16

VANDENBERG AIR FORCE BASE, CALIF. - Inside Orbital Sciences’ Building 1555 at Vandenberg Air Force Base in California, workers move the second half of the fairing into position around the Space Technology 5 (ST5) spacecraft. The ST5, which contains three microsatellites with miniaturized redundant components and technologies, is mated to its launch vehicle, Orbital Sciences' Pegasus XL. Each of the ST5 microsatellites will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. Launch of ST5 and the Pegasus XL will be from underneath the belly of an L-1011 carrier aircraft on March 14 from Vandenberg Air Force Base.

Disturbance Reduction Control Design for the ST7 Flight Validation Experiment

NASA Technical Reports Server (NTRS)

Maghami, P. G.; Hsu, O. C.; Markley, F. L.; Houghton, M. B.

2003-01-01

The Space Technology 7 experiment will perform an on-orbit system-level validation of two specific Disturbance Reduction System technologies: a gravitational reference sensor employing a free-floating test mass, and a set of micro-Newton colloidal thrusters. The ST7 Disturbance Reduction System is designed to maintain the spacecraft's position with respect to a free-floating test mass to less than 10 nm/Hz, over the frequency range of 1 to 30 mHz. This paper presents the design and analysis of the coupled, drag-free and attitude control systems that close the loop between the gravitational reference sensor and the micro-Newton thrusters, while incorporating star tracker data at low frequencies. A full 18 degree-of-freedom model, which incorporates rigid-body models of the spacecraft and two test masses, is used to evaluate the effects of actuation and measurement noise and disturbances on the performance of the drag-free system.

21st Century Locomotive Technology: Quarterly Technical Status Report 28

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lembit Salasoo; Ramu Chandra

2010-02-19

Thermal testing of a subscale locomotive sodium battery module was initiated.to validate thermal models. The hybrid trip optimizer problem was formulated. As outcomes of this project, GE has proceeded to commercialize trip optimizer technology, and has initiated work on a state-of-the-art battery manufacturing plant for high energy density, sodium-based batteries.

Colloid Microthruster Flight Performance Results from Space Technology 7 Disturbance Reduction System

NASA Technical Reports Server (NTRS)

Ziemer, John; Marrese-Reading, Colleen; Dunn, Charley; Romero-Wolf, Andrew; Cutler, Curt; Javidnia, Shahram; Li, Thanh; Li, Irena; Franklin, Garth; Barela, Phil;

iPads: Intuitive Technology for 21st-Century Students

ERIC Educational Resources Information Center

Siegle, Del

2013-01-01

The purpose of this article is to provide a rationale for using iPad technology with young students. Various inexpensive apps are described that parents and educators will find useful. (Contains 9 figures.)

A Model-based Approach to Controlling the ST-5 Constellation Lights-Out Using the GMSEC Message Bus and Simulink

NASA Technical Reports Server (NTRS)

Witt, Kenneth J.; Stanley, Jason; Shendock, Robert; Mandl, Daniel

2005-01-01

Space Technology 5 (ST-5) is a three-satellite constellation, technology validation mission under the New Millennium Program at NASA to be launched in March 2006. One of the key technologies to be validated is a lights-out, model-based operations approach to be used for one week to control the ST-5 constellation with no manual intervention. The ground architecture features the GSFC Mission Services Evolution Center (GMSEC) middleware, which allows easy plugging in of software components and a standardized messaging protocol over a software bus. A predictive modeling tool built on MatLab's Simulink software package makes use of the GMSEC standard messaging protocol to interface to the Advanced Mission Planning System (AMPS) Scenario Scheduler which controls all activities, resource allocation and real-time re-profiling of constellation resources when non-nominal events occur. The key features of this system, which we refer to as the ST-5 Simulink system, are as follows: Original daily plan is checked to make sure that predicted resources needed are available by comparing the plan against the model. As the plan is run in real-time, the system re-profiles future activities in real-time if planned activities do not occur in the predicted timeframe or fashion. Alert messages are sent out on the GMSEC bus by the system if future predicted problems are detected. This will allow the Scenario Scheduler to correct the situation before the problem happens. The predictive model is evolved automatically over time via telemetry updates thus reducing the cost of implementing and maintaining the models by an order of magnitude from previous efforts at GSFC such as the model-based system built for MAP in the mid-1990's. This paper will describe the key features, lessons learned and implications for future missions once this system is successfully validated on-orbit in 2006.

Validation of the VBLaST: A Virtual Peg Transfer Task in Gynecologic Surgeons

PubMed Central

Awtrey, CS; Chellali, A; Schwaitzberg, SD; De, S; Jones, DB; Cao, CGL

2016-01-01

Study Objective To validate the virtual reality VBLaST-PT (the peg transfer task) for concurrent validity based on its ability to differentiate between novice, intermediate and expert groups of gynecologists, and the gynecologists’ subjective preference between the physical FLS system and the virtual reality system. Design Prospective study (Canadian Task Force II-2) Setting Academic medical center. Participants Obstetrics and gynecology residents (n = 18), and attending gynecologists (n = 9) Interventions Twenty-seven subjects were divided into three groups: novices (PGY1-2, n = 9), intermediates (PGY3-4, n = 9), and experts (attendings, n = 9). All subjects performed ten trials of the peg transfer on each simulator. Assessment of laparoscopic performance was based on FLS scoring while a questionnaire was used for subjective evaluation. Measurements and Main Results The results show that the performance scores in the two simulators were nearly identical. Experts performed better than intermediates and novices in both the FLS trainer and the VBLAST© and intermediates performed better than novices in both simulators as well. The results also show a significant learning effect on both trainers for all subgroups however the greatest learning effect was in the novice group for both trainers. Subjectively 74% participants preferred the FLS over the VBLaST© for training laparoscopic surgical skills. Conclusion This study demonstrates that the peg transfer task was reproduced well in the VBLaST in gynecologic surgeons and trainee’s. The VBLaST© has the potential to be a valuable tool in laparoscopic training for gynecologic surgeons. PMID:26216094

Smartphone ECG for evaluation of ST-segment elevation myocardial infarction (STEMI): Design of the ST LEUIS International Multicenter Study.

PubMed

Barbagelata, Alejandro; Bethea, Charles F; Severance, Harry W; Mentz, Robert J; Albert, David; Barsness, Gregory W; Le, Viet T; Anderson, Jeffrey L; Bunch, T Jared; Yanowitz, Frank; Chisum, Benjamin; Ronnow, Brianna S; Muhlestein, Joseph B

In patients experiencing an ST-elevation myocardial infarction (STEMI), rapid diagnosis and immediate access to reperfusion therapy leads to optimal clinical outcomes. The rate-limiting step in STEMI diagnosis is the availability and performance of a 12-lead ECG. Recent technology has provided access to a reliable means of obtaining an ECG reading through a smartphone application (app) that works with an attachment providing all 12-leads of a standard ECG system. The ST LEUIS study was designed to validate the smartphone ECG app and its ability to accurately assess the presence or absence of STEMI in patients presenting with chest pain compared with the gold standard 12-lead ECG. We aimed to support the diagnostic utility of smartphone technology to provide a timely diagnosis and treatment of STEMI. The study will take place over 12months at five institutions. Approximately 60 patients will be enrolled per institution, for a total recruitment of 300 patients. Copyright © 2017 Elsevier Inc. All rights reserved.

KSC-06pd0433

NASA Image and Video Library

2006-02-14

VANDENBERG AIR FORCE BASE, CALIF. - Inside Orbital Sciences’ Building 1555 at Vandenberg Air Force Base in California, this closeup shows two of the Space Technology 5 (ST5) spacecraft's microsatellites mounted on the payload structure that is mated to the Orbital Sciences' Pegasus XL launch vehicle. In the background is the fairing that will enclose the ST5 for launch. The ST5 contains three microsatellites with miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled from the belly of an L-1011 carrier aircraft no earlier than March 14 from Vandenberg Air Force Base.

DoD Priorities for Autonomy Research and Development

DTIC Science & Technology

2011-10-21

Research and Development MORLEY O. STONE, ST, PhD Autonomy PSC Lead 21 October 2011 NDIA Disruptive Technologies Conference November 8-9, 2011...AVAILABILITY STATEMENT Approved for public release; distribution unlimited 13. SUPPLEMENTARY NOTES Presented at the NDIA Disruptive Technologies Conference

The Space Technology 5 Avionics System

NASA Technical Reports Server (NTRS)

Speer, Dave; Jackson, George; Stewart, Karen; Hernandez-Pellerano, Amri

2004-01-01

The Space Technology 5 (ST5) mission is a NASA New Millennium Program project that will validate new technologies for future space science missions and demonstrate the feasibility of building launching and operating multiple, miniature spacecraft that can collect research-quality in-situ science measurements. The three satellites in the ST5 constellation will be launched into a sun-synchronous Earth orbit in early 2006. ST5 fits into the 25-kilogram and 24-watt class of very small but fully capable spacecraft. The new technologies and design concepts for a compact power and command and data handling (C&DH) avionics system are presented. The 2-card ST5 avionics design incorporates new technology components while being tightly constrained in mass, power and volume. In order to hold down the mass and volume, and quali& new technologies for fUture use in space, high efficiency triple-junction solar cells and a lithium-ion battery were baselined into the power system design. The flight computer is co-located with the power system electronics in an integral spacecraft structural enclosure called the card cage assembly. The flight computer has a full set of uplink, downlink and solid-state recording capabilities, and it implements a new CMOS Ultra-Low Power Radiation Tolerant logic technology. There were a number of challenges imposed by the ST5 mission. Specifically, designing a micro-sat class spacecraft demanded that minimizing mass, volume and power dissipation would drive the overall design. The result is a very streamlined approach, while striving to maintain a high level of capability, The mission's radiation requirements, along with the low voltage DC power distribution, limited the selection of analog parts that can operate within these constraints. The challenge of qualifying new technology components for the space environment within a short development schedule was another hurdle. The mission requirements also demanded magnetic cleanliness in order to reduce the effect of stray (spacecraft-generated) magnetic fields on the science-grade magnetometer.

Through babies' eyes: Practical and theoretical considerations of using wearable technology to measure parent-infant behaviour from the mothers' and infants' view points.

PubMed

Lee, R; Skinner, A; Bornstein, M H; Radford, A N; Campbell, A; Graham, K; Pearson, R M

2017-05-01

To explore the utility of first-person viewpoint cameras at home, for recording mother and infant behaviour, and for reducing problems associated with participant reactivity, which represent a fundamental bias in observational research. We compared footage recording the same play interactions from a traditional third-person point of view (3rd PC) and using cameras worn on headbands (first-person cameras [1st PCs]) to record first-person points of view of mother and infant simultaneously. In addition, we left the dyads alone with the 1st PCs for a number of days to record natural mother-child behaviour at home. Fifteen mothers with infants (3-12 months of age) provided a total of 14h of footage at home alone with the 1st PCs. Codings of maternal behaviour from footage of the same scenario captured from 1st PCs and 3rd PCs showed high concordance (kappa >0.8). Footage captured by the 1st PCs also showed strong inter-rater reliability (kappa=0.9). Data from 1st PCs during sessions recorded alone at home captured more 'negative' maternal behaviours per min than observations using 1st PCs whilst a researcher was present (mean difference=0.90 (95% CI 0.5-1.2, p<0.001 representing 1.5 SDs). 1st PCs offer a number of practical advantages and can reliably record maternal and infant behaviour. This approach can also record a higher frequency of less socially desirable maternal behaviours. It is unclear whether this difference is due to lack of need of the presence of researcher or the increased duration of recordings. This finding is potentially important for research questions aiming to capture more ecologically valid behaviours and reduce demand characteristics. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

KSC-06pd0181

NASA Image and Video Library

2006-01-17

VANDENBERG AIR FORCE BASE, Calif. — At Vandenberg Air Force Base in California, workers are moving the Space Technology 5 (ST5) spacecraft into Orbital Sciences’ Building 1555. There it will be mated with the Pegasus XL launch vehicle. ST5 will be launched by a Pegasus XL rocket. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

KSC-06pd0445

NASA Image and Video Library

2006-02-14

VANDENBERG AIR FORCE BASE, CALIF. - Inside Orbital Sciences’ Building 1555 at Vandenberg Air Force Base in California, workers clean and prepare the fairing to be installed around the Space Technology 5 (ST5) spacecraft. The ST5 contains three microsatellites with miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled from the belly of an L-1011 carrier aircraft no earlier than March 14 from Vandenberg Air Force Base.

KSC-06pd0438

NASA Image and Video Library

2006-02-14

VANDENBERG AIR FORCE BASE, CALIF. - Inside Orbital Sciences’ Building 1555 at Vandenberg Air Force Base in California, workers check the Orbital Sciences' Pegasus XL launch vehicle before encapsulation of the Space Technology 5 (ST5) spacecraft. The ST5 contains three microsatellites with miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled from the belly of an L-1011 carrier aircraft no earlier than March 14 from Vandenberg Air Force Base.

KSC-06pd0186

NASA Image and Video Library

2006-01-18

VANDENBERG AIR FORCE BASE, Calif. — Inside Orbital Sciences’ Building 1555 at Vandenberg Air Force Base in California, the wrapped Space Technology 5 (ST5) spacecraft is revealed after removal of the shipping container. ST5 will be launched by a Pegasus XL rocket. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

KSC-06pd0437

NASA Image and Video Library

2006-02-14

VANDENBERG AIR FORCE BASE, CALIF. -Inside Orbital Sciences’ Building 1555 at Vandenberg Air Force Base in California, a worker checks connections on the Space Technology 5 (ST5) spacecraft before encapsulation with the fairing. The ST5, mated to Orbital Sciences' Pegasus XL launch vehicle, contains three microsatellites with miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled from the belly of an L-1011 carrier aircraft no earlier than March 14 from Vandenberg Air Force Base.

KSC-06pd0434

NASA Image and Video Library

2006-02-14

VANDENBERG AIR FORCE BASE, CALIF. - Inside Orbital Sciences’ Building 1555 at Vandenberg Air Force Base in California, this closeup shows the Space Technology 5 (ST5) spacecraft's microsatellites mounted on the payload structure. The spacecraft will be enclosed for launch. The ST5 contains three microsatellites with miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled from the belly of an L-1011 carrier aircraft no earlier than March 14 from Vandenberg Air Force Base.

KSC-06pd0180

NASA Image and Video Library

2006-01-17

VANDENBERG AIR FORCE BASE, Calif. — At Vandenberg Air Force Base in California, workers are moving the Space Technology 5 (ST5) spacecraft out of the truck into Orbital Sciences’ Building 1555. There it will be mated with the Pegasus XL launch vehicle. ST5 will be launched by a Pegasus XL rocket. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

KSC-06pd0179

NASA Image and Video Library

2006-01-17

VANDENBERG AIR FORCE BASE, Calif. — At Vandenberg Air Force Base in California, workers are moving the Space Technology 5 (ST5) spacecraft out of the Orbital Sciences Building 836 onto a truck for transfer to Building 1555. There it will be mated with the Pegasus XL launch vehicle. ST5 will be launched by a Pegasus XL rocket. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

KSC-06pd0177

NASA Image and Video Library

2006-01-16

VANDENBERG AIR FORCE BASE, Calif. — In the Orbital Sciences Building 836 at Vandenberg Air Force Base in California, a scale attached to a crane is ready to lift the payload support structure with the three micro-satellites comprising the Space Technology 5 (ST5) spacecraft. ST5 will be launched by a Pegasus XL rocket. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

KSC-06pd0173

NASA Image and Video Library

2006-01-16

VANDENBERG AIR FORCE BASE, Calif. — In In the Orbital Sciences Building 836 at Vandenberg Air Force Base in California, the payload support structure with the three micro-satellites comprising the Space Technology 5 (ST5) spacecraft has been raised to vertical to be weighed. ST5 will be launched by a Pegasus XL rocket. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

KSC-06pd0442

NASA Image and Video Library

2006-02-14

VANDENBERG AIR FORCE BASE, CALIF. - Inside Orbital Sciences’ Building 1555 at Vandenberg Air Force Base in California, workers prepare the fairing to be installed around the Space Technology 5 (ST5) spacecraft. The ST5 contains three microsatellites with miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled from the belly of an L-1011 carrier aircraft no earlier than March 14 from Vandenberg Air Force Base.

KSC-06pd0339

NASA Image and Video Library

2006-02-03

KENNEDY SPACE CENTER, FLA. - Inside Orbital Sciences’ Building 1555 at Vandenberg Air Force Base in California, workers begin the mating process of the Space Technology 5 (ST5), at right, with the Pegasus XL launch vehicle, at left. The ST5 contains three microsatellites, with miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled no earlier than March 6 from Vandenberg Air Force Base.

KSC-06pd0175

NASA Image and Video Library

2006-01-16

VANDENBERG AIR FORCE BASE, Calif. — In the Orbital Sciences Building 836 at Vandenberg Air Force Base in California, workers prepare the scale that will be used to weigh the three micro-satellites comprising the Space Technology 5 (ST5) spacecraft. ST5 will be launched by a Pegasus XL rocket. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

KSC-06pd0182

NASA Image and Video Library

2006-01-17

VANDENBERG AIR FORCE BASE, Calif. — At Vandenberg Air Force Base in California, workers are moving the Space Technology 5 (ST5) spacecraft into Orbital Sciences’ Building 1555. There it will be mated with the Pegasus XL launch vehicle. ST5 will be launched by a Pegasus XL rocket. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

KSC-06pd0336

NASA Image and Video Library

2006-02-03

KENNEDY SPACE CENTER, FLA. - Inside Orbital Sciences’ Building 1555 at Vandenberg Air Force Base in California, the Space Technology 5 (ST5) spacecraft is ready for mating to the Pegasus XL launch vehicle. Seen in the photo are the three satellites that make up the ST5, containing miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled no earlier than March 6 from Vandenberg Air Force Base.

KSC-06pd0185

NASA Image and Video Library

2006-01-18

VANDENBERG AIR FORCE BASE, Calif. — Inside Orbital Sciences’ Building 1555 at Vandenberg Air Force Base in California, the wrapped Space Technology 5 (ST5) spacecraft is revealed after removal of the shipping container. ST5 will be launched by a Pegasus XL rocket. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

KSC-06pd0176

NASA Image and Video Library

2006-01-16

VANDENBERG AIR FORCE BASE, Calif. — In the Orbital Sciences Building 836 at Vandenberg Air Force Base in California, a scale is attached to a crane that lifts the payload support structure with the three micro-satellites comprising the Space Technology 5 (ST5) spacecraft. ST5 will be launched by a Pegasus XL rocket. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

KSC-06pd0183

NASA Image and Video Library

2006-01-18

VANDENBERG AIR FORCE BASE, Calif. — Inside Orbital Sciences’ Building 1555 at Vandenberg Air Force Base in California, workers attach the wires to lift the shipping container surrounding the Space Technology 5 (ST5) spacecraft. ST5 will be launched by a Pegasus XL rocket. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

KSC-06pd0555

NASA Image and Video Library

2006-03-10

VANDENBERG AIR FORCE BASE, CALIF. - On the ramp adjacent to the runway at Vandenberg Air Force Base in California, the Space Technology 5's Pegasus rocket is placed in position to be mated to the underside of an Orbital Sciences L-1011 carrier aircraft. The ST5, which contains three microsatellites with miniaturized redundant components and technologies, is mated to its launch vehicle, Orbital Sciences' Pegasus XL. Each of the ST5 microsatellites will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. Launch of ST5 and the Pegasus XL will be from underneath the belly of an L-1011 carrier aircraft from Vandenberg Air Force Base.

KSC-06pd0441

NASA Image and Video Library

2006-02-14

VANDENBERG AIR FORCE BASE, CALIF. - Inside Orbital Sciences’ Building 1555 at Vandenberg Air Force Base in California, workers clean and prepare the fairing to be installed around the Space Technology 5 (ST5) spacecraft. The ST5 contains three microsatellites with miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled from the belly of an L-1011 carrier aircraft no earlier than March 14 from Vandenberg Air Force Base.

KSC-06pd0174

NASA Image and Video Library

2006-01-16

VANDENBERG AIR FORCE BASE, Calif. — In the Orbital Sciences Building 836 at Vandenberg Air Force Base in California, workers prepare the scale that will be used to weigh the three micro-satellites comprising the Space Technology 5 (ST5) spacecraft. ST5 will be launched by a Pegasus XL rocket. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

KSC-06pd0439

NASA Image and Video Library

2006-02-14

VANDENBERG AIR FORCE BASE, CALIF. - Inside Orbital Sciences’ Building 1555 at Vandenberg Air Force Base in California, one half of the fairing is being installed around the Space Technology 5 (ST5) spacecraft. The ST5 contains three microsatellites with miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled from the belly of an L-1011 carrier aircraft no earlier than March 14 from Vandenberg Air Force Base.

KSC-06pd0431

NASA Image and Video Library

2006-02-14

VANDENBERG AIR FORCE BASE, CALIF. - Inside Orbital Sciences’ Building 1555 at Vandenberg Air Force Base in California, the Space Technology 5 (ST5) spacecraft waits for encapsulation after mating with the Orbital Sciences' Pegasus XL launch vehicle. The ST5 contains three microsatellites with miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled from the belly of an L-1011 carrier aircraft no earlier than March 14 from Vandenberg Air Force Base.

KSC-06pd0184

NASA Image and Video Library

2006-01-18

VANDENBERG AIR FORCE BASE, Calif. — Inside Orbital Sciences’ Building 1555 at Vandenberg Air Force Base in California, workers assure the shipping container surrounding the Space Technology 5 (ST5) spacecraft is lifted safely. ST5 will be launched by a Pegasus XL rocket. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

KSC-06pd0440

NASA Image and Video Library

2006-02-14

VANDENBERG AIR FORCE BASE, CALIF. - Inside Orbital Sciences’ Building 1555 at Vandenberg Air Force Base in California, workers adjust the first half of the fairing being installed around the Space Technology 5 (ST5) spacecraft. The ST5 contains three microsatellites with miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled from the belly of an L-1011 carrier aircraft no earlier than March 14 from Vandenberg Air Force Base.

KSC-06pd0178

NASA Image and Video Library

2006-01-16

VANDENBERG AIR FORCE BASE, Calif. — In the Orbital Sciences Building 836 at Vandenberg Air Force Base in California, workers keep close watch as the payload support structure with the three micro-satellites comprising the Space Technology 5 (ST5) spacecraft is lifted and weighed. ST5 will be launched by a Pegasus XL rocket. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

Corps of Engineers Structural Engineering Conference Held in St. Johns County, Florida on 8-12 July 1991. Volume 1

DTIC Science & Technology

1992-12-01

ville, surveying personnel and surveyors at fects from the concrete heat of hydration, the Engineering Technology Laboratory and solar radiation, and...CESEC91 Schuitz 317 LA-J 4 zz C.I.A 4 -r Lfl- ST. PEER ST 0’ Uz M 0; ~ w z d L 0l Fra lwý CLu V)C,0 W V) -j V- u0) 318r Bctjt CEE9 A304MC. PANAlS - ELE

Extraction optimization and UHPLC method development for determination of the 20-hydroxyecdysone in Sida tuberculata leaves.

PubMed

da Rosa, Hemerson S; Koetz, Mariana; Santos, Marí Castro; Jandrey, Elisa Helena Farias; Folmer, Vanderlei; Henriques, Amélia Teresinha; Mendez, Andreas Sebastian Loureiro

2018-04-01

Sida tuberculata (ST) is a Malvaceae species widely distributed in Southern Brazil. In traditional medicine, ST has been employed as hypoglycemic, hypocholesterolemic, anti-inflammatory and antimicrobial. Additionally, this species is chemically characterized by flavonoids, alkaloids and phytoecdysteroids mainly. The present work aimed to optimize the extractive technique and to validate an UHPLC method for the determination of 20-hydroxyecdsone (20HE) in the ST leaves. Box-Behnken Design (BBD) was used in method optimization. The extractive methods tested were: static and dynamic maceration, ultrasound, ultra-turrax and reflux. In the Box-Behnken three parameters were evaluated in three levels (-1, 0, +1), particle size, time and plant:solvent ratio. In validation method, the parameters of selectivity, specificity, linearity, limits of detection and quantification (LOD, LOQ), precision, accuracy and robustness were evaluated. The results indicate static maceration as better technique to obtain 20HE peak area in ST extract. The optimal extraction from surface response methodology was achieved with the parameters granulometry of 710 nm, 9 days of maceration and plant:solvent ratio 1:54 (w/v). The UHPLC-PDA analytical developed method showed full viability of performance, proving to be selective, linear, precise, accurate and robust for 20HE detection in ST leaves. The average content of 20HE was 0.56% per dry extract. Thus, the optimization of extractive method in ST leaves increased the concentration of 20HE in crude extract, and a reliable method was successfully developed according to validation requirements and in agreement with current legislation. Copyright © 2018 Elsevier Inc. All rights reserved.

Data-to-Decisions S&T Priority Initiative

DTIC Science & Technology

2011-11-08

Context Mapping − Track Performance Model  Multi-Source Tracking − Track Fusion − Track through Gaps − Move-Stop-Move  Performance Based ...Decisions S&T Priority Initiative Dr. Carey Schwartz PSC Lead Office of Naval Research NDIA Disruptive Technologies Conference November 8-9, 2011...PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Office of Naval Research ,875 North Randolph Street , Arlington,VA,2217 8. PERFORMING ORGANIZATION REPORT

Monitoring of Dual CRISPR/Cas9-Mediated Steroidogenic Acute Regulatory Protein Gene Deletion and Cholesterol Accumulation Using High-Resolution Fluorescence In Situ Hybridization in a Single Cell

PubMed Central

Lee, Jinwoo; Jefcoate, Colin

2017-01-01

Recent advances in fluorescence microscopy, coupled with CRISPR/Cas9 gene editing technology, provide opportunities for understanding gene regulation at the single-cell level. The application of direct imaging shown here provides an in situ side-by-side comparison of CRISPR/Cas9-edited cells and adjacent unedited cells. We apply this methodology to the steroidogenic acute regulatory protein (StAR) gene in Y-1 adrenal cells and MA-10 testis cells. StAR is a gatekeeper protein that controls the access of cholesterol from the cytoplasm to the inner mitochondria. The loss of this mitochondrial cholesterol transfer mediator rapidly increases lipid droplets in cells, as seen in StAR−/− mice. Here, we describe a dual CRISPR/Cas9 strategy marked by GFP/mCherry expression that deletes StAR activity within 12 h. We used single-molecule fluorescence in situ hybridization (sm-FISH) imaging to directly monitor the time course of gene editing in single cells. We achieved StAR gene deletion at high efficiency dual gRNA targeting to the proximal promoter and exon 2. Seventy percent of transfected cells showed a slow DNA deletion as measured by PCR, and loss of Br-cAMP stimulated transcription. This DNA deletion was seen by sm-FISH in both loci of individual cells relative to non-target Cyp11a1 and StAR exon 7. sm-FISH also distinguishes two effects on stimulated StAR expression without this deletion. Br-cAMP stimulation of primary and spliced StAR RNA at the gene loci were removed within 4 h in this dual CRISPR/Cas9 strategy before any effect on cytoplasmic mRNA and protein occurred. StAR mRNA disappeared between 12 and 24 h in parallel with this deletion, while cholesterol ester droplets increased fourfold. These alternative changes match distinct StAR expression processes. This dual gRNA and sm-FISH approach to CRISPR/Cas9 editing facilitates rapid testing of editing strategies and immediate assessment of single-cell adaptation responses without the perturbation of clonal expansion procedures. PMID:29118738

Engineered Resilient Systems (ERS) S&T Priority Description and Roadmap

DTIC Science & Technology

2011-11-08

ERS PSC, NDIA Disruptive Technologies 8 November 2011 Page-1 Distribution Statement A: Approved for public release; distribution is unlimited...ODASD SE NDIA 8th Annual Disruptive Technologies Conference 8 November 2011 Report Documentation Page Form ApprovedOMB No. 0704-0188...release; distribution unlimited 13. SUPPLEMENTARY NOTES Presented at the NDIA Disruptive Technologies Conference, November 8,-9, 2011 Washington, DC 14

Validation of the Solving Problems Scale with Teachers

ERIC Educational Resources Information Center

Ryan, Mary Elizabeth

2011-01-01

Rapid advancements in technology, global competitiveness, and an increasing demand for 21st-century skills, such as problem-solving, underscore the pivotal role teachers play to prepare our youth for an era of exponential change. Those at the forefront of education are challenged to equip students with skills and strategies necessary to think…

KSC-06pd0432

NASA Image and Video Library

2006-02-14

VANDENBERG AIR FORCE BASE, CALIF. - Inside Orbital Sciences’ Building 1555 at Vandenberg Air Force Base in California, this photo shows two of the Space Technology 5 (ST5) spacecraft's microsatellites mounted on the payload structure that is mated to the Orbital Sciences' Pegasus XL launch vehicle. The ST5 contains three microsatellites with miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled from the belly of an L-1011 carrier aircraft no earlier than March 14 from Vandenberg Air Force Base.

KSC-06pd0556

NASA Image and Video Library

2006-03-10

VANDENBERG AIR FORCE BASE, CALIF. - On the ramp adjacent to the runway at Vandenberg Air Force Base in California, a worker positions the vertical fin within the Orbital Sciences L-1011 aircraft. The fin will then be attached to the Space Technology 5's Pegasus rocket which will be mated to the underside of the carrier aircraft. The ST5, which contains three microsatellites with miniaturized redundant components and technologies, is mated to its launch vehicle, Orbital Sciences' Pegasus XL. Each of the ST5 microsatellites will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. Launch of ST5 and the Pegasus XL will be from underneath the belly of an L-1011 carrier aircraft from Vandenberg Air Force Base.

KSC-06pd0436

NASA Image and Video Library

2006-02-14

VANDENBERG AIR FORCE BASE, CALIF. -Inside Orbital Sciences’ Building 1555 at Vandenberg Air Force Base in California is the Pegasus XL launch vehicle and the Space Technology 5 (ST5) spacecraft being prepared for encapsulation before launch. The ST5, mated to Orbital Sciences' Pegasus XL launch vehicle, contains three microsatellites with miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled from the belly of an L-1011 carrier aircraft no earlier than March 14 from Vandenberg Air Force Base.

Airborne Next: Rethinking Airborne Organization and Applying New Concepts

DTIC Science & Technology

2015-06-01

9 Kenneth Macksey, Guderian: Panzer General-revised EDITION (South Yorkshire, England: Greenhill Books, 2003), 1–20. 10 Dr. John Arquilla...Airborne Operations: Field Manual 90=26, 1–5. 14 The 1st Special Forces Regiment has five active Special Forces Groups (1st, 3rd, 5th , 7th, 10th...Oxford University Press, 1981). Headrick, in his book, describes the interplay between technology and imperialism. For the purposes of this research

Multi-Evaporator Miniature Loop Heat Pipe for Small Spacecraft Thermal Control. Part 1; New Technologies and Validation Approach

NASA Technical Reports Server (NTRS)

Ku, Jentung; Ottenstein, Laura; Douglas, Donya; Hoang, Triem

2010-01-01

Under NASA s New Millennium Program Space Technology 8 (ST 8) Project, four experiments Thermal Loop, Dependable Microprocessor, SAILMAST, and UltraFlex - were conducted to advance the maturity of individual technologies from proof of concept to prototype demonstration in a relevant environment , i.e. from a technology readiness level (TRL) of 3 to a level of 6. This paper presents the new technologies and validation approach of the Thermal Loop experiment. The Thermal Loop is an advanced thermal control system consisting of a miniature loop heat pipe (MLHP) with multiple evaporators and multiple condensers designed for future small system applications requiring low mass, low power, and compactness. The MLHP retains all features of state-of-the-art loop heat pipes (LHPs) and offers additional advantages to enhance the functionality, performance, versatility, and reliability of the system. Details of the thermal loop concept, technical advances, benefits, objectives, level 1 requirements, and performance characteristics are described. Also included in the paper are descriptions of the test articles and mathematical modeling used for the technology validation. An MLHP breadboard was built and tested in the laboratory and thermal vacuum environments for TRL 4 and TRL 5 validations, and an MLHP proto-flight unit was built and tested in a thermal vacuum chamber for the TRL 6 validation. In addition, an analytical model was developed to simulate the steady state and transient behaviors of the MLHP during various validation tests. Capabilities and limitations of the analytical model are also addressed.

KSC-06pd0188

NASA Image and Video Library

2006-01-18

VANDENBERG AIR FORCE BASE, Calif. — Inside Orbital Sciences’ Building 1555 at Vandenberg Air Force Base in California, the wrapped Space Technology 5 (ST5) spacecraft is ready for mating to the Pegasus XL launch vehicle. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

KSC-06pd0187

NASA Image and Video Library

2006-01-18

VANDENBERG AIR FORCE BASE, Calif. — Inside Orbital Sciences’ Building 1555 at Vandenberg Air Force Base in California, the wrapped Space Technology 5 (ST5) spacecraft is being prepared for mating to the Pegasus XL launch vehicle. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

MicroRNA156: A Potential Graft-Transmissible MicroRNA That Modulates Plant Architecture and Tuberization in Solanum tuberosum ssp. andigena1[C][W][OPEN

PubMed Central

Bhogale, Sneha; Mahajan, Ameya S.; Natarajan, Bhavani; Rajabhoj, Mohit; Thulasiram, Hirekodathakallu V.; Banerjee, Anjan K.

2014-01-01

MicroRNA156 (miR156) functions in maintaining the juvenile phase in plants. However, the mobility of this microRNA has not been demonstrated. So far, only three microRNAs, miR399, miR395, and miR172, have been shown to be mobile. We demonstrate here that miR156 is a potential graft-transmissible signal that affects plant architecture and tuberization in potato (Solanum tuberosum). Under tuber-noninductive (long-day) conditions, miR156 shows higher abundance in leaves and stems, whereas an increase in abundance of miR156 has been observed in stolons under tuber-inductive (short-day) conditions, indicative of a photoperiodic control. Detection of miR156 in phloem cells of wild-type plants and mobility assays in heterografts suggest that miR156 is a graft-transmissible signal. This movement was correlated with changes in leaf morphology and longer trichomes in leaves. Overexpression of miR156 in potato caused a drastic phenotype resulting in altered plant architecture and reduced tuber yield. miR156 overexpression plants also exhibited altered levels of cytokinin and strigolactone along with increased levels of LONELY GUY1 and StCyclin D3.1 transcripts as compared with wild-type plants. RNA ligase-mediated rapid amplification of complementary DNA ends analysis validated SQUAMOSA PROMOTER BINDING-LIKE3 (StSPL3), StSPL6, StSPL9, StSPL13, and StLIGULELESS1 as targets of miR156. Gel-shift assays indicate the regulation of miR172 by miR156 through StSPL9. miR156-resistant SPL9 overexpression lines exhibited increased miR172 levels under a short-day photoperiod, supporting miR172 regulation via the miR156-SPL9 module. Overall, our results strongly suggest that miR156 is a phloem-mobile signal regulating potato development. PMID:24351688

Developing prediction equations and a mobile phone application to identify infants at risk of obesity.

PubMed

Santorelli, Gillian; Petherick, Emily S; Wright, John; Wilson, Brad; Samiei, Haider; Cameron, Noël; Johnson, William

2013-01-01

Advancements in knowledge of obesity aetiology and mobile phone technology have created the opportunity to develop an electronic tool to predict an infant's risk of childhood obesity. The study aims were to develop and validate equations for the prediction of childhood obesity and integrate them into a mobile phone application (App). Anthropometry and childhood obesity risk data were obtained for 1868 UK-born White or South Asian infants in the Born in Bradford cohort. Logistic regression was used to develop prediction equations (at 6 ± 1.5, 9 ± 1.5 and 12 ± 1.5 months) for risk of childhood obesity (BMI at 2 years >91(st) centile and weight gain from 0-2 years >1 centile band) incorporating sex, birth weight, and weight gain as predictors. The discrimination accuracy of the equations was assessed by the area under the curve (AUC); internal validity by comparing area under the curve to those obtained in bootstrapped samples; and external validity by applying the equations to an external sample. An App was built to incorporate six final equations (two at each age, one of which included maternal BMI). The equations had good discrimination (AUCs 86-91%), with the addition of maternal BMI marginally improving prediction. The AUCs in the bootstrapped and external validation samples were similar to those obtained in the development sample. The App is user-friendly, requires a minimum amount of information, and provides a risk assessment of low, medium, or high accompanied by advice and website links to government recommendations. Prediction equations for risk of childhood obesity have been developed and incorporated into a novel App, thereby providing proof of concept that childhood obesity prediction research can be integrated with advancements in technology.

Student's Interest in Science and Technology and Its Relationships with Teaching Methods, Family Context and Self-Efficacy

ERIC Educational Resources Information Center

Hasni, Abdelkrim; Potvin, Patrice

2015-01-01

In order to explore students' interest towards S&T, we developed and validated a questionnaire that simultaneously takes into account 18 components (general interest in school-S&T, utility of school-S&T, teaching methods preferences, perceived importance and preference for school-S&T with respect to other school subjects, etc.).…

Why don't young people want to become engineers? Rational reasons for disappointing decisions

NASA Astrophysics Data System (ADS)

Becker, Frank Stefan

2010-08-01

The quest for engineers during the past boom and predictions of future shortages have focused attention on the low enrolment figures in science and technology (S&T) subjects. Normally, it is assumed that young people shy away from 'tough majors' or make irrational choices, based on an absence of information. While not denying the fundamental necessity that a higher proportion of the population should have a background in S&T, this paper pursues a different approach. Only by identifying potentially valid reasons for the lack of interest in S&T will it be possible to change not just some 'misguided' perceptions among the younger generation, but to categorise the facts and make targeted recommendations for necessary changes. Therefore, this article will discuss the importance of image and status, the influence of society and peer groups, as well as financial rewards and career aspects. It will be shown that the universally observable trend away from S&T is not due to a dislike of technology on the part of the younger generation, but is caused by the fact that careers in this field do not seem attractive enough, especially in comparison with alternatives available in developed countries. Some recommendations to improve this situation are offered.

Space Technology 5 (ST-5) Multipoint Observations of Temporal and Spatial Variability of Field-Aligned Currents

NASA Technical Reports Server (NTRS)

Le, Guan

2010-01-01

Space Technology 5 (ST-5) is a three micro-satellite constellation deployed into a 300 x 4500 km, dawn-dusk, sun-synchronous polar orbit from March 22 to June 21, 2006, for technology validations. In this paper, we present a study of the temporal variability of field-aligned currents using multi-point magnetic field measurements from ST5. The data demonstrate that mesoscale current structures are commonly embedded within large-scale field-aligned current sheets. The meso-scale current structures are very dynamic with highly variable current density and/or polarity in time scales of about 10 min. They exhibit large temporal variations during both quiet and disturbed times in such time scales. On the other hand, the data also shown that the time scales for the currents to be relatively stable are about 1 min for meso-scale currents and about 10 min for large scale current sheets. These temporal features are obviously associated with dynamic variations of their particle carriers (mainly electrons) as they respond to the variations of the parallel electric field in auroral acceleration region. The characteristic time scales for the temporal variability of meso-scale field-aligned currents are found to be consistent with those of auroral parallel electric field.

Multi-Evaporator Miniature Loop Heat Pipe for Small Spacecraft Thermal Control. Part 2; Validation Results

NASA Technical Reports Server (NTRS)

Ku, Jentung; Ottenstein, Laura; Douglas, Donya; Hoang, Triem

2010-01-01

Under NASA s New Millennium Program Space Technology 8 (ST 8) Project, Goddard Space Fight Center has conducted a Thermal Loop experiment to advance the maturity of the Thermal Loop technology from proof of concept to prototype demonstration in a relevant environment , i.e. from a technology readiness level (TRL) of 3 to a level of 6. The thermal Loop is an advanced thermal control system consisting of a miniature loop heat pipe (MLHP) with multiple evaporators and multiple condensers designed for future small system applications requiring low mass, low power, and compactness. The MLHP retains all features of state-of-the-art loop heat pipes (LHPs) and offers additional advantages to enhance the functionality, performance, versatility, and reliability of the system. An MLHP breadboard was built and tested in the laboratory and thermal vacuum environments for the TRL 4 and TRL 5 validations, respectively, and an MLHP proto-flight unit was built and tested in a thermal vacuum chamber for the TRL 6 validation. In addition, an analytical model was developed to simulate the steady state and transient behaviors of the MLHP during various validation tests. The MLHP demonstrated excellent performance during experimental tests and the analytical model predictions agreed very well with experimental data. All success criteria at various TRLs were met. Hence, the Thermal Loop technology has reached a TRL of 6. This paper presents the validation results, both experimental and analytical, of such a technology development effort.

Amylases StAmy23, StBAM1 and StBAM9 regulate cold-induced sweetening of potato tubers in distinct ways

PubMed Central

Hou, Juan; Zhang, Huiling; Liu, Jun; Reid, Stephen; Liu, Tengfei; Xu, Shijing; Tian, Zhendong; Sonnewald, Uwe

2017-01-01

Abstract Cold-induced sweetening (CIS) in potato is detrimental to the quality of processed products. Conversion of starch to reducing sugars (RS) by amylases is considered one of the main pathways in CIS but is not well studied. The amylase genes StAmy23, StBAM1, and StBAM9 were studied for their functions in potato CIS. StAmy23 is localized in the cytoplasm, whereas StBAM1 and StBAM9 are targeted to the plastid stroma and starch granules, respectively. Genetic transformation of these amylases in potatoes by RNA interference showed that β-amylase activity could be decreased in cold-stored tubers by silencing of StBAM1 and collective silencing of StBAM1 and StBAM9. However, StBAM9 silencing did not decrease β-amylase activity. Silencing StBAM1 and StBAM9 caused starch accumulation and lower RS, which was more evident in simultaneously silenced lines, suggesting functional redundancy. Soluble starch content increased in RNAi-StBAM1 lines but decreased in RNAi-StBAM9 lines, suggesting that StBAM1 may regulate CIS by hydrolysing soluble starch and StBAM9 by directly acting on starch granules. Moreover, StBAM9 interacted with StBAM1 on the starch granules. StAmy23 silencing resulted in higher phytoglycogen and lower RS accumulation in cold-stored tubers, implying that StAmy23 regulates CIS by degrading cytosolic phytoglycogen. Our findings suggest that StAmy23, StBAM1, and StBAM9 function in potato CIS with varying levels of impact. PMID:28369567

A web-based tool to predict acute kidney injury in patients with ST-elevation myocardial infarction: Development, internal validation and comparison.

PubMed

Zambetti, Benjamin R; Thomas, Fridtjof; Hwang, Inyong; Brown, Allen C; Chumpia, Mason; Ellis, Robert T; Naik, Darshan; Khouzam, Rami N; Ibebuogu, Uzoma N; Reed, Guy L

2017-01-01

In ST-elevation myocardial infarction (STEMI), acute kidney injury (AKI) may increase subsequent morbidity and mortality. Still, it remains difficult to predict AKI risk in these patients. We sought to 1) determine the frequency and clinical outcomes of AKI and, 2) develop, validate and compare a web-based tool for predicting AKI. In a racially diverse series of 1144 consecutive STEMI patients, Stage 1 or greater AKI occurred in 12.9% and was severe (Stage 2-3) in 2.9%. AKI was associated with increased mortality (5.7-fold, unadjusted) and hospital stay (2.5-fold). AKI was associated with systolic dysfunction, increased left ventricular end-diastolic pressures, hypotension and intra-aortic balloon counterpulsation. A computational algorithm (UT-AKI) was derived and internally validated. It showed higher sensitivity and improved overall prediction for AKI (area under the curve 0.76) vs. other published indices. Higher UT-AKI scores were associated with more severe AKI, longer hospital stay and greater hospital mortality. In a large, racially diverse cohort of STEMI patients, Stage 1 or greater AKI was relatively common and was associated with significant morbidity and mortality. A web-accessible, internally validated tool was developed with improved overall value for predicting AKI. By identifying patients at increased risk, this tool may help physicians tailor post-procedural diagnostic and therapeutic strategies after STEMI to reduce AKI and its associated morbidity and mortality.

KSC-06pd0172

NASA Image and Video Library

2006-01-13

VANDENBERG AIR FORCE BASE, Calif. — In the Orbital Sciences Building 836 at Vandenberg Air Force Base in California, the three micro-satellites comprising the Space Technology 5 spacecraft are mated and ready for weighing. ST5 will be launched by a Pegasus XL rocket. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

KSC-06pd0169

NASA Image and Video Library

2006-01-13

VANDENBERG AIR FORCE BASE, Calif. — In the Orbital Sciences Building 836 at Vandenberg Air Force Base in California, technicians complete mating of the three micro-satellites on the payload support structure. The three satellites make up the Space Technology 5 spacecraft, called ST5, and will be launched by a Pegasus XL rocket. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

KSC-06pd0161

NASA Image and Video Library

2006-01-12

VANDENBERG AIR FORCE BASE, Calif. — In the Orbital Sciences Building 836 at Vandenberg Air Force Base in California, workers move lift one of three micro-satellites to prepare it for mating to the payload support structure. The three satellites that make up the Space Technology 5 spacecraft, called ST5, will be launched by a Pegasus XL rocket. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

KSC-06pd0170

NASA Image and Video Library

2006-01-13

VANDENBERG AIR FORCE BASE, Calif. — In the Orbital Sciences Building 836 at Vandenberg Air Force Base in California, technicians complete mating of the three micro-satellites on the payload support structure. The three satellites make up the Space Technology 5 spacecraft, called ST5, and will be launched by a Pegasus XL rocket. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

KSC-06pd0162

NASA Image and Video Library

2006-01-12

VANDENBERG AIR FORCE BASE, Calif. — In the Orbital Sciences Building 836 at Vandenberg Air Force Base in California, workers guide one of three micro-satellites onto a payload support structure. The three satellites that make up the Space Technology 5 spacecraft, called ST5, will be launched by a Pegasus XL rocket. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

KSC-06pd0167

NASA Image and Video Library

2006-01-12

VANDENBERG AIR FORCE BASE, Calif. — In the Orbital Sciences Building 836 at Vandenberg Air Force Base in California, workers are mating a third satellite onto the payload support structure. The three satellites make up the Space Technology 5 spacecraft, called ST5, and will be launched by a Pegasus XL rocket. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

KSC-06pd0168

NASA Image and Video Library

2006-01-12

VANDENBERG AIR FORCE BASE, Calif. — In the Orbital Sciences Building 836 at Vandenberg Air Force Base in California, three micro-satellites are mounted on the payload support structure. The three satellites make up the Space Technology 5 spacecraft, called ST5, and will be launched by a Pegasus XL rocket. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

KSC-06pd0163

NASA Image and Video Library

2006-01-12

VANDENBERG AIR FORCE BASE, Calif. — In the Orbital Sciences Building 836 at Vandenberg Air Force Base in California, workers secure one of three micro-satellites onto a payload support structure. The three satellites that make up the Space Technology 5 spacecraft, called ST5, will be launched by a Pegasus XL rocket. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

KSC-06pd0171

NASA Image and Video Library

2006-01-13

VANDENBERG AIR FORCE BASE, Calif. — In the Orbital Sciences Building 836 at Vandenberg Air Force Base in California, technicians complete mating of the three micro-satellites on the payload support structure. The three satellites make up the Space Technology 5 spacecraft, called ST5, and will be launched by a Pegasus XL rocket. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

Redefining Community: Small Colleges in the Information Age. The Pew Symposia in Learning and Technology (5th, Charleston, South Carolina, October 9-10, 2001).

ERIC Educational Resources Information Center

Twigg, Carol A.

A symposium on the challenges and opportunities facing small institutions as they move into the 21st century was held to allow participants the opportunity to describe their own initiatives and to hear the views of representatives of larger institutions with technology mediated programs. The paper provides an overview of the strategic issues…

Electromagnetic Contact-Force Sensing Electrophysiological Catheters: How Accurate is the Technology?

PubMed

Bourier, Felix; Hessling, Gabriele; Ammar-Busch, Sonia; Kottmaier, Marc; Buiatti, Alessandra; Grebmer, Christian; Telishevska, Marta; Semmler, Verena; Lennerz, Carsten; Schneider, Christine; Kolb, Christof; Deisenhofer, Isabel; Reents, Tilko

2016-03-01

Contact-force (CF) sensing catheters are increasingly used in clinical electrophysiological practice due to their efficacy and safety profile. As data about the accuracy of this technology are scarce, we sought to quantify accuracy based on in vitro experiments. A custom-made force sensor was constructed that allowed exact force reference measurements registered via a flexible membrane. A Smarttouch Surround Flow (ST SF) ablation catheter (Biosense Webster, Diamond Bar, CA, USA) was brought in contact with the membrane of the force sensor in order to compare the ST SF force measurements to force sensor reference measurements. ST SF force sensing technology is based on deflection registration between the distal and proximal catheter tip. The experiment was repeated for n = 10 ST SF catheters, which showed no significant difference in accuracy levels. A series of measurements (n = 1200) was carried out for different angles of force acting to the catheter tip (0°/perpendicular contact, 30°, 60°, 90°/parallel contact). The mean absolute differences between reference and ST SF measurements were 1.7 ± 1.8 g (0°), 1.6 ± 1.2 g (30°), 1.4 ± 1.3 g (60°), and 6.6 ± 5.9 g (90°). Measurement accuracy was significantly higher in non-parallel contact when compared with parallel contact (P < 0.01). Catheter force measurements using the ST SF catheters show a high level of accuracy regarding differences to reference measurements and reproducibility. The reduced accuracy in measurements of 90° acting forces (parallel contact) might be clinically important when creating, for example, linear lesions. © 2015 Wiley Periodicals, Inc.

Uncertainties in Engineering Design. Mathematical Theory and Numerical Experience.

DTIC Science & Technology

1985-08-01

Theoretical Mannual, Noetic Technologies Corpora- tion, St. Louis, Missouri, 1985. F :.5,. "V. .. " ,9.., 25 . - 5* 5 .° . . . . .. ,koA ’FIGURES...international center of study and research for foreign students in numerical mathematics who are supported by foreign govern- ments or exchange agencies

Status of the dedicated short-range communications technology and applications : report to Congress.

DOT National Transportation Integrated Search

2015-07-01

This report responds to a Congressional request for an assessment of the 5.9 Gigahertz (GHz) Dedicated Short Range Communications (DSRC) in accordance with the requirements provided by Congress in the Moving Ahead for Progress in the 21st Century Act...

A validation method for near-infrared spectroscopy based tissue oximeters for cerebral and somatic tissue oxygen saturation measurements.

PubMed

Benni, Paul B; MacLeod, David; Ikeda, Keita; Lin, Hung-Mo

2018-04-01

We describe the validation methodology for the NIRS based FORE-SIGHT ELITE ® (CAS Medical Systems, Inc., Branford, CT, USA) tissue oximeter for cerebral and somatic tissue oxygen saturation (StO 2 ) measurements for adult subjects submitted to the United States Food and Drug Administration (FDA) to obtain clearance for clinical use. This validation methodology evolved from a history of NIRS validations in the literature and FDA recommended use of Deming regression and bootstrapping statistical validation methods. For cerebral validation, forehead cerebral StO 2 measurements were compared to a weighted 70:30 reference (REF CX B ) of co-oximeter internal jugular venous and arterial blood saturation of healthy adult subjects during a controlled hypoxia sequence, with a sensor placed on the forehead. For somatic validation, somatic StO 2 measurements were compared to a weighted 70:30 reference (REF CX S ) of co-oximetry central venous and arterial saturation values following a similar protocol, with sensors place on the flank, quadriceps muscle, and calf muscle. With informed consent, 25 subjects successfully completed the cerebral validation study. The bias and precision (1 SD) of cerebral StO 2 compared to REF CX B was -0.14 ± 3.07%. With informed consent, 24 subjects successfully completed the somatic validation study. The bias and precision of somatic StO 2 compared to REF CX S was 0.04 ± 4.22% from the average of flank, quadriceps, and calf StO 2 measurements to best represent the global whole body REF CX S . The NIRS validation methods presented potentially provide a reliable means to test NIRS monitors and qualify them for clinical use.

Encouraging Students with Different Profiles of Perceptions to Pursue Science by Choosing Appropriate Teaching Methods for Each Age Group

NASA Astrophysics Data System (ADS)

Potvin, Patrice; Hasni, Abdelkrim

2017-06-01

This research aimed at identifying student profiles of perceptions by means of a clustering method using a validated questionnaire. These profiles describe students' attraction to science and technology (S&T) studies and careers as a variable driven by school S&T self-concept and interest in school S&T. In addition to three rather predictable student profiles (confident enthusiast, average ambitious, and pessimistic dropout), the fourth fairly well-populated profile called confident indifferent was produced. Our second and third research questions allowed us to describe each profile in terms of the instructional methods to which their population was exposed (including the degree to which they were actively involved) and the instructional methods to which they would like more exposure. An analysis of the evolution of the profiles' population over time is also presented. The results suggest that pedagogical variety and active involvement in the decision to pursue S&T are important. The perception of the utility and importance of S&T both in and out of school may also play an important role in these decisions. Minor pedagogical preferences were also found in certain age groups.

Validation of the multiplex ligation-dependent probe amplification assay and its application on the distribution study of the major alleles of 17 blood group systems in Chinese donors from Guangzhou.

PubMed

Ji, Yanli; Wen, Jizhi; Veldhuisen, Barbera; Haer-Wigman, Lonneke; Wang, Zhen; Lodén-van Straaten, Martin; Wei, Ling; Luo, Guangping; Fu, Yongshui; van der Schoot, C Ellen

2017-02-01

Genotyping platforms for common red blood cell (RBC) antigens have been successfully applied in Caucasian and black populations but not in Chinese populations. In this study, a genotyping assay based on multiplex ligation-dependent probe amplification (MLPA) technology was applied in a Chinese population to validate the MLPA probes. Subsequently, the comprehensive distribution of 17 blood group systems also was obtained. DNA samples from 200 Chinese donors were extracted and genotyped using the blood-MLPA assay. To confirm the MLPA results, a second independent genotyping assay (ID Core+) was conducted in 40 donors, and serological typing of 14 blood-group antigens was performed in 91 donors. In donors who had abnormal copy numbers of an allele (DI and GYPB) determined by MLPA, additional experiments were performed (polymerase chain reaction, sequencing, and flow cytometry analysis). The genotyping results obtained using the blood-MLPA and ID Core+ assays were consistent. Serological data were consistent with the genotyping results except for one donor who had a Lu(a-b-) phenotype. Of the 17 blood group systems, the distribution of the MNS, Duffy, Kidd, Diego, Yt, and Dombrock systems was polymorphic. The Mur and St a antigens of the MNS system were distributed with a frequency of 9% (18 of 200) and 2% (4 of 200), respectively. One donor with chimerism and one who carried a novel DI*02(A845V) allele, which predicts the depression of Di b antigen expression, were identified. The blood-MLPA assay could easily identify the common blood-group alleles and correctly predicted phenotype in the Chinese population. The Mur and St a antigens were distributed with high frequency in a Southern Chinese Han population. © 2016 AABB.

Replication of Rubella Vaccine Population Genetic Studies: Validation of HLA Genotype and Humoral Response Associations

PubMed Central

Ovsyannikova, Inna G.; Jacobson, Robert M.; Vierkant, Robert A.; O’Byrne, Megan M.; Poland, Gregory A.

2009-01-01

Purported genetic associations found in population studies require validation for confirmation. We previously reported rubella vaccine-induced immune responses and HLA associations in 346 adolescents, age 12–18 years (1st cohort), following two doses of a rubella-containing vaccine. We sought to replicate the associations discovered in that work by verifying these associations in a new cohort of 396 subjects, age 11–19 years (2nd cohort), all having had two doses of a rubella-containing vaccine. We found that B*2705 (median 1st cohort 20.9 IU/ml, p=0.028; 2nd cohort 20.5 IU/ml, p=0.001) and DPA1*0201 (median 1st cohort 32.5 IU/ml, p=0.048; 2nd cohort 25.8 IU/ml, p=0.025) alleles were consistently associated with lower rubella-induced antibodies. Further, DPB1*0401 (median 1st cohort 43.5 IU/ml, p=0.021; 2nd cohort 36.2 IU/ml, p=0.002) alleles were associated with higher antibody levels in both populations. The association of DRB1*04-DQB1*03-DPB1*03 (mean 1st cohort 25.2 IU/ml, p=0.011; 2nd cohort 21.4 IU/ml, p=0.032) and DRB1*15/16-DQB1*06-DPB1*03 (1st cohort 16.3 IU/ml, p=0.043; 2nd cohort 19.1 IU/ml, p=0.023) haplotypes with lower rubella-specific antibodies were observed in both studies. This study provides confirmatory evidence for an association between specific class I and II HLA markers and haplotypes with rubella vaccine-induced humoral responses and lends further weight to their influence on rubella immune responses. PMID:19761839

New molecular markers and cytogenetic probes enable chromosome identification of wheat-Thinopyrum intermedium introgression lines for improving protein and gluten contents.

PubMed

Li, Guangrong; Wang, Hongjin; Lang, Tao; Li, Jianbo; La, Shixiao; Yang, Ennian; Yang, Zujun

2016-10-01

New molecular markers were developed for targeting Thinopyrum intermedium 1St#2 chromosome, and novel FISH probe representing the terminal repeats was produced for identification of Thinopyrum chromosomes. Thinopyrum intermedium has been used as a valuable resource for improving the disease resistance and yield potential of wheat. A wheat-Th. intermedium ssp. trichophorum chromosome 1St#2 substitution and translocation has displayed superior grain protein and wet gluten content. With the aim to develop a number of chromosome 1St#2 specific molecular and cytogenetic markers, a high throughput, low-cost specific-locus amplified fragment sequencing (SLAF-seq) technology was used to compare the sequences between a wheat-Thinopyrum 1St#2 (1D) substitution and the related species Pseudoroegneria spicata (St genome, 2n = 14). A total of 5142 polymorphic fragments were analyzed and 359 different SLAF markers for 1St#2 were predicted. Thirty-seven specific molecular markers were validated by PCR from 50 randomly selected SLAFs. Meanwhile, the distribution of transposable elements (TEs) at the family level between wheat and St genomes was compared using the SLAFs. A new oligo-nucleotide probe named Oligo-pSt122 from high SLAF reads was produced for fluorescence in situ hybridization (FISH), and was observed to hybridize to the terminal region of 1St#L and also onto the terminal heterochromatic region of Th. intermedium genomes. The genome-wide markers and repetitive based probe Oligo-pSt122 will be valuable for identifying Thinopyrum chromosome segments in wheat backgrounds.

78 FR 7440 - Agency Information Collection Activities: Submission for Review; Information Collection Extension...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-01

... (DHS Form 10008); (9) Application for SAFETY Act Certification (DHS Form 10007); (10) SAFETY Act Block Designation Application (DHS Form 10005); and (11) SAFETY Act Block Certification Application (DHS Form 10004... distribution chain. The Department of Homeland Security Science & Technology Directorate (DHS S&T) currently...

Flight Computer Design for the Space Technology 5 (ST-5) Mission

NASA Technical Reports Server (NTRS)

Speer, David; Jackson, George; Raphael, Dave; Day, John H. (Technical Monitor)

2001-01-01

As part of NASA's New Millennium Program, the Space Technology 5 mission will validate a variety of technologies for nano-satellite and constellation mission applications. Included are: a miniaturized and low power X-band transponder, a constellation communication and navigation transceiver, a cold gas micro-thruster, two different variable emittance (thermal) controllers, flex cables for solar array power collection, autonomous groundbased constellation management tools, and a new CMOS ultra low-power, radiation-tolerant, +0.5 volt logic technology. The ST-5 focus is on small and low-power. A single-processor, multi-function flight computer will implement direct digital and analog interfaces to all of the other spacecraft subsystems and components. There will not be a distributed data system that uses a standardized serial bus such as MIL-STD-1553 or MIL-STD-1773. The flight software running on the single processor will be responsible for all real-time processing associated with: guidance, navigation and control, command and data handling (C&DH) including uplink/downlink, power switching and battery charge management, science data analysis and storage, intra-constellation communications, and housekeeping data collection and logging. As a nanosatellite trail-blazer for future constellations of up to 100 separate space vehicles, ST-5 will demonstrate a compact (single board), low power (5.5 watts) solution to the data acquisition, control, communications, processing and storage requirements that have traditionally required an entire network of separate circuit boards and/or avionics boxes. In addition to the New Millennium technologies, other major spacecraft subsystems include the power system electronics, a lithium-ion battery, triple-junction solar cell arrays, a science-grade magnetometer, a miniature spinning sun sensor, and a propulsion system.

Delivery of Colloid Micro-Newton Thrusters for the Space Technology 7 Mission

NASA Technical Reports Server (NTRS)

Ziemer, John K.; Randolph, Thomas M.; Franklin, Garth W.; Hruby, Vlad; Spence, Douglas; Demmons, Nathaniel; Roy, Thomas; Ehrbar, Eric; Zwahlen, Jurg; Martin, Roy;

A large‐scale view of Space Technology 5 magnetometer response to solar wind drivers

PubMed Central

Kilcommons, L. M.; Gjerloev, J.; Redmon, R. J.; Slavin, J.; Le, G.

2015-01-01

Abstract In this data report we discuss reprocessing of the Space Technology 5 (ST5) magnetometer database for inclusion in NASA's Coordinated Data Analysis Web (CDAWeb) virtual observatory. The mission consisted of three spacecraft flying in elliptical orbits, from 27 March to 27 June 2006. Reprocessing includes (1) transforming the data into the Modified Apex Coordinate System for projection to a common reference altitude of 110 km, (2) correcting gain jumps, and (3) validating the results. We display the averaged magnetic perturbations as a keogram, which allows direct comparison of the full‐mission data with the solar wind values and geomagnetic indices. With the data referenced to a common altitude, we find the following: (1) Magnetic perturbations that track the passage of corotating interaction regions and high‐speed solar wind; (2) unexpectedly strong dayside perturbations during a solstice magnetospheric sawtooth oscillation interval characterized by a radial interplanetary magnetic field (IMF) component that may have enhanced the accompanying modest southward IMF; and (3) intervals of reduced magnetic perturbations or “calms,” associated with periods of slow solar wind, interspersed among variable‐length episodic enhancements. These calms are most evident when the IMF is northward or projects with a northward component onto the geomagnetic dipole. The reprocessed ST5 data are in very good agreement with magnetic perturbations from the Defense Meteorological Satellite Program (DMSP) spacecraft, which we also map to 110 km. We briefly discuss the methods used to remap the ST5 data and the means of validating the results against DMSP. Our methods form the basis for future intermission comparisons of space‐based magnetometer data. PMID:27981071

A large-scale view of Space Technology 5 magnetometer response to solar wind drivers.

PubMed

Knipp, D J; Kilcommons, L M; Gjerloev, J; Redmon, R J; Slavin, J; Le, G

2015-04-01

In this data report we discuss reprocessing of the Space Technology 5 (ST5) magnetometer database for inclusion in NASA's Coordinated Data Analysis Web (CDAWeb) virtual observatory. The mission consisted of three spacecraft flying in elliptical orbits, from 27 March to 27 June 2006. Reprocessing includes (1) transforming the data into the Modified Apex Coordinate System for projection to a common reference altitude of 110 km, (2) correcting gain jumps, and (3) validating the results. We display the averaged magnetic perturbations as a keogram, which allows direct comparison of the full-mission data with the solar wind values and geomagnetic indices. With the data referenced to a common altitude, we find the following: (1) Magnetic perturbations that track the passage of corotating interaction regions and high-speed solar wind; (2) unexpectedly strong dayside perturbations during a solstice magnetospheric sawtooth oscillation interval characterized by a radial interplanetary magnetic field (IMF) component that may have enhanced the accompanying modest southward IMF; and (3) intervals of reduced magnetic perturbations or "calms," associated with periods of slow solar wind, interspersed among variable-length episodic enhancements. These calms are most evident when the IMF is northward or projects with a northward component onto the geomagnetic dipole. The reprocessed ST5 data are in very good agreement with magnetic perturbations from the Defense Meteorological Satellite Program (DMSP) spacecraft, which we also map to 110 km. We briefly discuss the methods used to remap the ST5 data and the means of validating the results against DMSP. Our methods form the basis for future intermission comparisons of space-based magnetometer data.

The ConocoPhillips Center for a Sustainable WE2ST (Water-Energy Education, Science, and Technology): Lessons Learned from an Innovative Research-Education-Outreach Center at Colorado School of Mines

NASA Astrophysics Data System (ADS)

Hogue, T. S.; Blaine, A. C.; Martin, A. C.

2016-12-01

The ConocoPhillips Center for a Sustainable WE2ST (Water-Energy Education, Science, and Technology) is a testament to the power of collaboration and innovation. WE2ST began as a partnership between ConocoPhillips (foundation gift) and the Colorado School of Mines (CSM) with the goal of fostering solutions to water-energy challenges via education, research and outreach. The WE2ST center is a training ground for the next generation of water-energy-social scientists and engineers and is a natural fit for CSM, which is known for its expertise in water resources, water treatment technologies, petroleum engineering, geosciences, and hydrology. WE2ST has nine contributing faculty researchers that combine to create a web of expertise on sustainable energy and water resources. This research benefits unconventional energy producers, water-reliant stakeholders and the general public. Areas of focus for research include water sources (quality and quantity), integrated water-energy solution viability and risk, and social-corporate responsibility. The WE2ST Center currently provides annual support for 8-9 Graduate Fellows and 13 Undergraduate Scholars. Top-tier graduate students are recruited nationally and funded similar to an NSF Graduate Research Fellowship (GRF). Undergraduate Scholars are also recruited from across the CSM campus to gain experience in faculty laboratories and on research teams. All WE2ST students receive extensive professional skills training, leadership development, communication skills training, networking opportunities in the water-energy industries, and outreach opportunities in the community. The corner stone of the WE2ST Center is a focus on communication with the public. Both in social science research teams and in general interactions with the public, WE2ST seeks to be "an honest broker" amidst a very passionate and complex topic. WE2ST research is communicated by presentations at technical conferences, talking with people at public gatherings, engaging in K-12 classroom activities and events, and by using websites and social media to share information. This presentation will highlight the successes and lessons learned as we enter the third year of this innovative model for a University Center.

Catch the Wave: The Future Is Now. Proceedings of the National Conference of the Association for Media and Technology in Education in Canada (St. John's, Newfoundland, Canada, June 9-12, 1990).

ERIC Educational Resources Information Center

Kennedy, Mary F., Ed.; And Others

The 22 papers in this proceedings were presented at the 1990 Association for Media and Technology in Education in Canada (AMTEC) conference: (1-3) "Selected Quotations" (R. Heinich, D. Beckwith, P. D. Mitchell); (4) "Responses to P. David Mitchell"; (5) "Build It and They Will Come--Creating the 3rd Wave: The Field of…

Effectiveness of the IDEFICS intervention on objectively measured physical activity and sedentary time in European children.

PubMed

Verbestel, V; De Henauw, S; Barba, G; Eiben, G; Gallois, K; Hadjigeorgiou, C; Konstabel, K; Maes, L; Mårild, S; Molnár, D; Moreno, L A; Oja, L; Pitsiladis, Y; Ahrens, W; Pigeot, I; De Bourdeaudhuij, I

2015-12-01

This paper reports on the effectiveness of the prevention of dietary- and lifestyle-induced health effects in children and infants (IDEFICS) intervention on objectively measured physical activity (PA) and sedentary time (ST) in 2- to 9.9-year-old European boys and girls. The intervention was evaluated after 2 years through a non-randomized cluster-controlled trial in eight European countries (one control and one intervention community per country). All children in the intervention group received a culturally adapted childhood obesity prevention programme through the community, schools/kindergartens and family. A random sub-sample of children participating in the IDEFICS study wore an accelerometer at baseline and follow-up for at least 3 days (n = 9,184). Of this sample, 81% provided valid accelerometer data at baseline (n = 7,413; 51% boys; 6.21 ± 1.76 years; boys: 617 ± 170 cpm day(-1) ; girls 556 ± 156 cpm day(-1) ) and 3,010 children provided valid accelerometer data at baseline and during the follow-up survey 2 years later. In boys and girls, no significant differences in PA and ST were found between intervention and control groups over 2 years. Strong temporal effects were found in the total sample of boys and girls: the percentage of time spent in light PA per day decreased by 4 percentage points in both boys and girls between baseline and follow-up (both: p < 0.001), while time spent in ST per day increased by 4 percentage points in both sexes over time (both: p < 0.001). Percentage of time spent in moderate-to-vigorous PA per day remained stable over time in boys and girls. Despite the socio-ecological approach and implementation of a culturally adapted intervention in each country, no effects of the IDEFICS intervention were found on children's objectively measured PA and ST. Behavioural interventions for children may need to enhance specificity and intensity at the family level using other behaviour change techniques and more direct strategies to reach parents. © 2015 World Obesity.

High-performance superconductors for Fusion Nuclear Science Facility

DOE PAGES

Zhai, Yuhu; Kessel, Chuck; Barth, Christian; ...

2016-11-09

High-performance superconducting magnets play an important role in the design of the next step large-scale, high-field fusion reactors such as the fusion nuclear science facility (FNSF) and the spherical tokamak (ST) pilot plant beyond ITER. Here, Princeton Plasma Physics Laboratory is currently leading the design studies of the FNSF and the ST pilot plant study. ITER, which is under construction in the south of France, utilizes the state-of-the-art low temperature superconducting magnet technology based on the cable-in-conduit conductor design, where over a thousand multifilament Nb 3Sn superconducting strands are twisted together to form a high-current-carrying cable inserted into a steelmore » jacket for coil windings. We present design options of the high-performance superconductors in the winding pack for the FNSF toroidal field magnet system based on the toroidal field radial build from the system code. For the low temperature superconductor options, the advanced J cNb 3Sn RRP strands (J c > 1000 A/mm 2 at 16 T, 4 K) from Oxford Superconducting Technology are under consideration. For the high-temperature superconductor options, the rectangular-shaped high-current HTS cable made of stacked YBCO tapes will be considered to validate feasibility of TF coil winding pack design for the ST-FNSF magnets.« less

High-performance superconductors for Fusion Nuclear Science Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhai, Yuhu; Kessel, Chuck; Barth, Christian

High-performance superconducting magnets play an important role in the design of the next step large-scale, high-field fusion reactors such as the fusion nuclear science facility (FNSF) and the spherical tokamak (ST) pilot plant beyond ITER. Here, Princeton Plasma Physics Laboratory is currently leading the design studies of the FNSF and the ST pilot plant study. ITER, which is under construction in the south of France, utilizes the state-of-the-art low temperature superconducting magnet technology based on the cable-in-conduit conductor design, where over a thousand multifilament Nb 3Sn superconducting strands are twisted together to form a high-current-carrying cable inserted into a steelmore » jacket for coil windings. We present design options of the high-performance superconductors in the winding pack for the FNSF toroidal field magnet system based on the toroidal field radial build from the system code. For the low temperature superconductor options, the advanced J cNb 3Sn RRP strands (J c > 1000 A/mm 2 at 16 T, 4 K) from Oxford Superconducting Technology are under consideration. For the high-temperature superconductor options, the rectangular-shaped high-current HTS cable made of stacked YBCO tapes will be considered to validate feasibility of TF coil winding pack design for the ST-FNSF magnets.« less

CRIS Cyber Range Lexicon Version 1.0 (Report 59 0001)

DTIC Science & Technology

2015-11-27

Evaluation (T&E) Support Cell, TRMC/ Northrop Grumman ) Dr. David “Fuzzy” Wells (USPACOM) Mr. Bennett Wilson (NAVSEA GOV – CDSA, Damneck...9 Figure 4: Planes and Teams...Communities supported by the CRIS WG include, but are not limited to, Science & Technology (S&T) experimentation , Developmental and Operational Test and

The New Career and Technical School

ERIC Educational Resources Information Center

Reese, Susan

2005-01-01

The 21st century career tech school brings together academics and career skills for a complete education. This article describes the new Romeo Engineering & Technology Center (RETC) in Romeo, Michigan. The 90,288-square-foot facility accommodates up to 720 students in grades 9-12, and sports a building design that evolved through a detailed,…

Incorporating New Technologies for 21st Century Toxicity ...

EPA Pesticide Factsheets

Presentation at the GlobalChem conference in Washington, DC on Incorporating New Technologies for 21st Century Toxicity Testing and Risk Assessment Presentation at the GlobalChem conference in Washington, DC on Incorporating New Technologies for 21st Century Toxicity Testing and Risk Assessment

KSC-06pd0166

NASA Image and Video Library

2006-01-12

VANDENBERG AIR FORCE BASE, Calif. — n the Orbital Sciences Building 836 at Vandenberg Air Force Base in California, a third satellite is transported across the floor. It will be mounted with the other satellites on the payload support structure. The three satellites make up the Space Technology 5 spacecraft, called ST5, and will be launched by a Pegasus XL rocket. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

KSC-06pd0165

NASA Image and Video Library

2006-01-12

VANDENBERG AIR FORCE BASE, Calif. — In the Orbital Sciences Building 836 at Vandenberg Air Force Base in California, workers lower the second satellite onto the payload support structure. Three micro-satellites are being mounted on a payload support structure. The three satellites make up the Space Technology 5 spacecraft, called ST5, and will be launched by a Pegasus XL rocket. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

KSC-06pd0164

NASA Image and Video Library

2006-01-12

VANDENBERG AIR FORCE BASE, Calif. — In the Orbital Sciences Building 836 at Vandenberg Air Force Base in California, workers are maneuvering a second satellite suspended by an overhead crane. Three micro-satellites are being mounted on a payload support structure. The three satellites make up the Space Technology 5 spacecraft, called ST5, and will be launched by a Pegasus XL rocket. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

Expanding educational access and opportunities: The globalization and foreign direct investment of multinational corporations and their influence on STEM, project-based learning and the national science and technology fair in schools in Costa Rica

NASA Astrophysics Data System (ADS)

Valdez, Joaquin G.

The purpose of this qualitative study was to examine the influence of globalization and the foreign direct investment (FDI) of multinational corporations (MNCs) on the curriculum in schools in Costa Rica. The study focused primarily on Science, Technology, Engineering and Mathematics (STEM), Project-Based Learning (PBL), 21st century skills, and the national science and technology fair. The high influx of MNCs such as Intel has changed the global and educational culture of the country increasing the number of knowledge-based workers in Costa Rica. As a result, policy changes have been instituted in education to mirror the demands of sustaining the country's global economy. This study was supported by the creation of three research questions that would attempt to answer 1) the extent that teachers implementing STEM curriculum trace their practices back to policy, globalization, and multinational corporations as well as the extent to which the economic growth of Costa Rica and STEM education are related, 2) how mandating the national science and technology fair has influenced 21st century skills through project-based learning and the use of technology by teachers and its impact on curriculum and instruction, and 3) how has the national science and technology fair policy changed the value of STEM education for students, teachers, and educational leaders. To further understand the outcome of this study, four theoretical frameworks were applied that included, Spring's theory of world educational culture, Friedman's world flatteners, Wagner's 21st century skills and partnerships for 21st century skills, and Slough and Milam's STEM project-based learning theoretical framework. Each framework was applied to support the changes to the educational system; survival skills necessary to compete in the global job market; application of 21st century skills in the classroom and in the science projects students created. A research team comprised of 14 doctoral students, led by Dr. Michael Escalante, studied the influence of globalization and FDI on MNCs on the educational system in Costa Rica. Data collection for this qualitative case study included the use of various instruments including surveys, interviews, and observations. A total of 20 participants were interviewed and 174 students and 33 teachers were surveyed in support of the findings for this study. The use of multiple sources helped to triangulate the data and increase the validity of the findings.

A Novel Method making direct use of AIRS and IASI Calibrated Radiances for Measuring Trends in Surface Temperatures

NASA Astrophysics Data System (ADS)

Aumann, H. H.; Ruzmaikin, A.

2014-12-01

Making unbiased measurements of trends in the surface temperatures, particularly on a gobal scale, is challenging: While the non-frozen oceans temperature measurements are plentiful and accurate, land and polar areas are much less accurately or fairly sampled. Surface temperature deduced from infrared radiometers on polar orbiting satellites (e.g. the Atmospheric Infrared Sounder (AIRS) at 1:30PM, the Interferometer Atmosphere Sounding Interferometer (IASI) at 9:30 AM and the MODerate resolution Imaging Spectro-radiometer (MODIS) at 1:30PM), can produce what appear to be well sampled data, but dealing with clouds either by cloud filtering (MODIS, IASI) or cloud-clearing (AIRS) can create sampling bias. We use a novel method: Random Nadir Sampling (RNS) combined with Probability Density Function (PDF) analysis. We analyze the trend in the PDF of st1231, the water vapor absorption corrected brightness temperatures measured in the 1231 cm-1 atmospheric window channel. The advantage of this method is that trends can be directly traced to the known, less than 3 mK/yr trend for AIRS, in st1231. For this study we created PDFs from 22,000 daily RNS from the AIRS and IASI data. We characterized the PDFs by its daily 90%tile value, st1231p90, and analysed the statistical properties of the this time series between 2002 and 2014. The method was validated using the daily NOAA SST (RTGSST) from the non-frozen oceans: The mean, seasonal variability and anomaly trend of st1231p90 agree with the corrsponding values from the RTGSST and the anomaly correlation is larger than 0.9. Preliminary results (August 2014) confirm the global hiatus in the increase of the globally averaged surface temperatures between 2002 and 2014, with a change of less than 10 mK/yr. This uncertainty is dominated by the large interannual variability related to El Niño events. Further insite is gained by analyzing land/ocean, day/night, artic and antarctic trends. We observe a massive warming trend in the Artic between 2002 and 2007, which has since level off, but no significant trend in the Antarctic. The AIRS results since 2002 are confirmed by IASI data since 2007. This work was supported by the Jet Propulsion Laboratory of the California Institute of Technology, under a contract with the National Aeronautics and Space Administration.

Preliminary Face and Construct Validation Study of a Virtual Basic Laparoscopic Skill Trainer

PubMed Central

Sankaranarayanan, Ganesh; Lin, Henry; Arikatla, Venkata S.; Mulcare, Maureen; Zhang, Likun; Derevianko, Alexandre; Lim, Robert; Fobert, David; Cao, Caroline; Schwaitzberg, Steven D.; Jones, Daniel B.

2010-01-01

Abstract Background The Virtual Basic Laparoscopic Skill Trainer (VBLaST™) is a developing virtual-reality–based surgical skill training system that incorporates several of the tasks of the Fundamentals of Laparoscopic Surgery (FLS) training system. This study aimed to evaluate the face and construct validity of the VBLaST™ system. Materials and Methods Thirty-nine subjects were voluntarily recruited at the Beth Israel Deaconess Medical Center (Boston, MA) and classified into two groups: experts (PGY 5, fellow and practicing surgeons) and novice (PGY 1–4). They were then asked to perform three FLS tasks, consisting of peg transfer, pattern cutting, and endoloop, on both the VBLaST and FLS systems. The VBLaST performance scores were automatically computed, while the FLS scores were rated by a trained evaluator. Face validity was assessed using a 5-point Likert scale, varying from not realistic/useful (1) to very realistic/useful (5). Results Face-validity scores showed that the VBLaST system was significantly realistic in portraying the three FLS tasks (3.95 ± 0.909), as well as the reality in trocar placement and tool movements (3.67 ± 0.874). Construct-validity results show that VBLaST was able to differentiate between the expert and novice group (P = 0.015). However, of the two tasks used for evaluating VBLaST, only the peg-transfer task showed a significant difference between the expert and novice groups (P = 0.003). Spearman correlation coefficient analysis between the two scores showed significant correlation for the peg-transfer task (Spearman coefficient 0.364; P = 0.023). Conclusions VBLaST demonstrated significant face and construct validity. A further set of studies, involving improvement to the current VBLaST system, is needed to thoroughly demonstrate face and construct validity for all the tasks. PMID:20201683

A comparison between patients with epiphora and cataract of the activity limitations they experience in daily life due to their visual disability.

PubMed

Bohman, Elin; Wyon, Maria; Lundström, Mats; Dafgård Kopp, Eva

2018-02-01

The objective of this study was to compare patients with epiphora and cataract in terms of the activity limitations they experience in daily life due to their visual disability and to validate the use of the Catquest-9SF questionnaire for epiphora patients. Seventy-two consecutively encountered adult patients with confirmed lacrimal obstruction and listed for dacryocystorhinostomy (DCR) or lacrimal intubation at the St. Erik Eye Hospital, Stockholm, Sweden, completed the Catquest-9SF questionnaire, which measures activity limitations in daily life due to visual disability. The psychometric qualities of the Catquest-9SF results obtained from this group of patients were evaluated by Rasch analysis. Rasch analysis was further employed to convert the ordinal raw data to a Rasch score for comparison with the preoperative scores of patients registered in the Swedish National Cataract Register (NCR) during March 2013. The Catquest-9SF exhibited good psychometric qualities when investigating epiphora patients, with the exception of a misfit for Item 4, the item regarding facial recognition. On the Rasch scale (-5.43 = no activity limitations to +5.01 = severe activity limitations), the mean score for epiphora patients was -0.82 while for patients listed for 1st eye and 2nd eye cataract surgery it was -0.17 and -0.76, respectively. An equivalence test confirmed that the reported visual disability of epiphora patients was not significantly different from visual disability reported by patients waiting for 2nd eye cataract surgery. The Catquest-9SF is a valid measure of visual disability in patients with epiphora. Epiphora patients experience visual disability to the same degree as patients awaiting 2nd eye cataract surgery. © 2017 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

Space Technology 5 (ST-5) Observations of the Imbalance of Region 1 and 2 Field-Aligned Currents

NASA Technical Reports Server (NTRS)

Le, Guan

2010-01-01

Space Technology 5 (ST-5) is a three micro-satellite constellation deployed into a 300 x 4500 km, dawn-dusk, sun-synchronous polar orbit from March 22 to June 21, 2006, for technology validations. In this study, we use the in-situ magnetic field observations from Space Technology 5 mission to quantify the imbalance of Region 1 (R1) and Region 2 (R2) currents. During the three-month duration of the ST5 mission, geomagnetic conditions range from quiet to moderately active. We find that the R1 current intensity is consistently stronger than the R2 current intensity both for the dawnside and the duskside large-scale field-aligned current system. The net currents flowing into (out of) the ionosphere in the dawnside (duskside) are in the order of 5% of the total RI currents. We also find that the net currents flowing into or out of the ionosphere are controlled by the solar wind-magnetosphere interaction in the same way as the field-aligned currents themselves are. Since the net currents due to the imbalance of the R1 and R2 currents require that their closure currents flow across the polar cap from dawn to dusk as Pedersen currents, our results indicate that the total amount of the cross-polar cap Pedersen currents is in the order of approx. 0.1 MA. This study, although with a very limited dataset, is one of the first attempts to quantify the cross-polar cap Pedersen currents. Given the importance of the Joule heating due to Pedersen currents to the high-latitude ionospheric electrodynamics, quantifying the cross-polar cap Pedersen currents and associated Joule heating is needed for developing models of the magnetosphere-ionosphere coupling.

SETI: another way to find habitable worlds

NASA Astrophysics Data System (ADS)

Tarter, Jill

2003-10-01

There are currently eleven active SETI (search for extraterrestrial intelligence) programs on telescopes around the world. They operate at microwave and optical frequencies, as either sky surveys or targeted searches in the direction of (primarily) solar-type stars. Each is attempting to detect an electromagnetic biosignature of a technological civilization. Although detectable technologies will be far older than our own, these searches are constrained by our current understanding of physics and the terrestrial technologies available in the 21st century. Moore's Law suggests that most of these detection technologies will improve their capacity exponentially. Thus if any of the current strategies is valid, a thorough exploration of the Milky Way Galaxy should be possible within decades (not centuries), and success, or a significant null-result is predictable. Giving up, incorporating new search strategies based on emergent technologies, or adding beacon transmission to the listening strategies are all future possibilities.

Multi-Evaporator Miniature Loop Heat Pipe for Small Spacecraft Thermal Control

NASA Technical Reports Server (NTRS)

Ku, Jentung; Ottenstein, Laura; Douglas, Donya

2008-01-01

This paper presents the development of the Thermal Loop experiment under NASA's New Millennium Program Space Technology 8 (ST8) Project. The Thermal Loop experiment was originally planned for validating in space an advanced heat transport system consisting of a miniature loop heat pipe (MLHP) with multiple evaporators and multiple condensers. Details of the thermal loop concept, technical advances and benefits, Level 1 requirements and the technology validation approach are described. An MLHP breadboard has been built and tested in the laboratory and thermal vacuum environments, and has demonstrated excellent performance that met or exceeded the design requirements. The MLHP retains all features of state-of-the-art loop heat pipes and offers additional advantages to enhance the functionality, performance, versatility, and reliability of the system. In addition, an analytical model has been developed to simulate the steady state and transient operation of the MHLP, and the model predictions agreed very well with experimental results. A protoflight MLHP has been built and is being tested in a thermal vacuum chamber to validate its performance and technical readiness for a flight experiment.

Innovations in Military Organizations

DTIC Science & Technology

1990-12-01

Although there are 14 many generalizations made by some researchers but they are not certain rules. According to John Naisbitt, author of Megatrends ...adverse and economic biological structural and changes. attitude changes 10-15 Infrastructure Industrial and Long-term systems institutional health...NAISBITT, John, Megatrends , 1st ed., 1983. 8. SUMANTH, D. J., Challenges and Opportunities in Managing Technology, 1988. 9. UTTERBACK, James

Validation of Two Temperature Pill Telemetry Systems in Humans During Moderate and Strenuous Exercise

DTIC Science & Technology

1992-10-01

The concept of using a temperature sensor in a pill as a clinical thermometer Is good, but mobility of the pill makes it less suitable as a research...Human Technologies, Inc. (CorTempt m; St. Petersburg, FL). Both systems included an ingestible temperature sensor /pill, a receiver, and a data storage...telemetry pills did, and T, and T. showed a faster response to changing core temperature than did T,. The concept of using a temperature sensor in a

Highlights of Nanosatellite Development Program at NASA-Goddard Space Flight Center

NASA Technical Reports Server (NTRS)

Rhee, Michael S.; Zakrzwski, Chuck M.; Thomas, Mike A.; Bauer, Frank H. (Technical Monitor)

2000-01-01

Currently the GN&C's Propulsion Branch of the NASA's Goddard Space Flight Center (GSFC) is conducting a broad technology development program for propulsion devices that are ideally suited for nanosatellite missions. The goal of our program is to develop nanosatellite propulsion systems that can be flight qualified in a few years and flown in support of nanosatellite missions. The miniature cold gas thruster technology, the first product from the GSFC's propulsion component technology development program, will be flown on the upcoming ST-5 mission in 2003. The ST-5 mission is designed to validate various nanosatellite technologies in all major subsystem areas. It is a precursor mission to more ambitious nanosatellite missions such as the Magnetospheric Constellation mission. By teaming with the industry and government partners, the GSFC propulsion component technology development program is aimed at pursuing a multitude of nanosatellite propulsion options simultaneously, ranging from miniaturized thrusters based on traditional chemical engines to MEMS based thruster systems. After a conceptual study phase to determine the feasibility and the applicability to nanosatellite missions, flight like prototypes of selected technology are fabricated for testing. The development program will further narrow down the effort to those technologies that are considered "mission-enabling" for future nanosatellite missions. These technologies will be flight qualified to be flown on upcoming nanosatellite missions. This paper will report on the status of our development program and provide details on the following technologies: Low power miniature cold gas thruster Nanosatellite solid rocket motor. Solid propellant gas generator system for cold gas thruster. Low temperature hydrazine blends for miniature hydrazine thruster. MEMS mono propellant thruster using hydrogen peroxide.

27 CFR 9.149 - St. Helena.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false St. Helena. 9.149 Section... THE TREASURY LIQUORS AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.149 St. Helena. (a) Name. The name of the viticultural area described in this section is “St. Helena.” (b...

Validation of administrative case ascertainment algorithms for chronic childhood arthritis in Manitoba, Canada.

PubMed

Shiff, Natalie Jane; Oen, Kiem; Rabbani, Rasheda; Lix, Lisa M

2017-09-01

We validated case ascertainment algorithms for juvenile idiopathic arthritis (JIA) in the provincial health administrative databases of Manitoba, Canada. A population-based pediatric rheumatology clinical database from April 1st 1980 to March 31st 2012 was used to test case definitions in individuals diagnosed at ≤15 years of age. The case definitions varied the number of diagnosis codes (1, 2, or 3), time frame (1, 2 or 3 years), time between diagnoses (ever, >1 day, or ≥8 weeks), and physician specialty. Positive predictive value (PPV), sensitivity, and specificity with 95% confidence intervals (CIs) are reported. A case definition of 1 hospitalization or ≥2 diagnoses in 2 years by any provider ≥8 weeks apart using diagnosis codes for rheumatoid arthritis and ankylosing spondylitis produced a sensitivity of 89.2% (95% CI 86.8, 91.6), specificity of 86.3% (95% CI 83.0, 89.6), and PPV of 90.6% (95% CI 88.3, 92.9) when seronegative enthesopathy and arthropathy (SEA) was excluded as JIA; and sensitivity of 88.2% (95% CI 85.7, 90.7), specificity of 90.4% (95% CI 87.5, 93.3), and PPV of 93.9% (95% CI 92.0, 95.8) when SEA was included as JIA. This study validates case ascertainment algorithms for JIA in Canadian administrative health data using diagnosis codes for both rheumatoid arthritis (RA) and ankylosing spondylitis, to better reflect current JIA classification than codes for RA alone. Researchers will be able to use these results to define cohorts for population-based studies.

Developing Teaching Material Software Assisted for Numerical Methods

NASA Astrophysics Data System (ADS)

Handayani, A. D.; Herman, T.; Fatimah, S.

2017-09-01

The NCTM vision shows the importance of two things in school mathematics, which is knowing the mathematics of the 21st century and the need to continue to improve mathematics education to answer the challenges of a changing world. One of the competencies associated with the great challenges of the 21st century is the use of help and tools (including IT), such as: knowing the existence of various tools for mathematical activity. One of the significant challenges in mathematical learning is how to teach students about abstract concepts. In this case, technology in the form of mathematics learning software can be used more widely to embed the abstract concept in mathematics. In mathematics learning, the use of mathematical software can make high level math activity become easier accepted by student. Technology can strengthen student learning by delivering numerical, graphic, and symbolic content without spending the time to calculate complex computing problems manually. The purpose of this research is to design and develop teaching materials software assisted for numerical method. The process of developing the teaching material starts from the defining step, the process of designing the learning material developed based on information obtained from the step of early analysis, learners, materials, tasks that support then done the design step or design, then the last step is the development step. The development of teaching materials software assisted for numerical methods is valid in content. While validator assessment for teaching material in numerical methods is good and can be used with little revision.

Frontiers in Educational Computing. Association for Educational Data Systems Annual Convention Proceedings (21st, Portland, Oregon, May 9-13, 1983).

ERIC Educational Resources Information Center

Association for Educational Data Systems, Washington, DC.

The 98 papers in this collection examine a wide variety of topics related to the latest technological developments as they apply to the educational process. Papers are grouped to reflect common, broad areas of interest, representing the instructional, administrative, and computer science divisions of the Association for Educational Data Systems…

Optimizing Human Cognition

DTIC Science & Technology

2013-01-01

decision, unless so designated by other documentation. 12. DISTRIBUTION AVAILIBILITY STATEMENT Approved for public release; distribution is unlimited. UU 9...SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) 6. AUTHORS 7. PERFORMING ORGANIZATION NAMES AND ADDRESSES U.S. Army Research Office P.O. Box...12211 Research Triangle Park, NC 27709-2211 15. SUBJECT TERMS Human Attention Eran Zaidel Pacific Development and Technology LLC 999 Commercial St

Space Technology 5 Multi-Point Observations of Temporal Variability of Field-Aligned Currents

NASA Technical Reports Server (NTRS)

Le, Guan; Wang, Yongli; Slavin, James A.; Strangeway, Robert J.

2008-01-01

Space Technology 5 (ST5) is a three micro-satellite constellation deployed into a 300 x 4500 km, dawn-dusk, sun-synchronous polar orbit from March 22 to June 21, 2006, for technology validations. In this paper, we present a study of the temporal variability of field-aligned currents using multi-point magnetic field measurements from ST5. The data demonstrate that meso-scale current structures are commonly embedded within large-scale field-aligned current sheets. The meso-scale current structures are very dynamic with highly variable current density and/or polarity in time scales of approximately 10 min. They exhibit large temporal variations during both quiet and disturbed times in such time scales. On the other hand, the data also shown that the time scales for the currents to be relatively stable are approximately 1 min for meso-scale currents and approximately 10 min for large scale current sheets. These temporal features are obviously associated with dynamic variations of their particle carriers (mainly electrons) as they respond to the variations of the parallel electric field in auroral acceleration region. The characteristic time scales for the temporal variability of meso-scale field-aligned currents are found to be consistent with those of auroral parallel electric field.

Space Technology 5 (ST-5) Observations of Field-Aligned Currents: Temporal Variability

NASA Technical Reports Server (NTRS)

Le, Guan

2010-01-01

Space Technology 5 (ST-5) is a three micro-satellite constellation deployed into a 300 x 4500 km, dawn-dusk, sun-synchronous polar orbit from March 22 to June 21, 2006, for technology validations. In this paper, we present a study of the temporal variability of field-aligned currents using multi-point magnetic field measurements from STS. The data demonstrate that masoscale current structures are commonly embedded within large-scale field-aligned current sheets. The meso-scale current structures are very dynamic with highly variable current density and/or polarity in time scales of about 10 min. They exhibit large temporal variations during both quiet and disturbed times in such time scales. On the other hand, the data also shown that the time scales for the currents to be relatively stable are about I min for meso-scale currents and about 10 min for large scale current sheets. These temporal features are obviously associated with dynamic variations of their particle carriers (mainly electrons) as they respond to the variations of the parallel electric field in auroral acceleration region. The characteristic time scales for the temporal variability of meso-scale field-aligned currents are found to be consistent with those of auroral parallel electric field.

Space Technology 5 Multi-point Observations of Field-aligned Currents: Temporal Variability of Meso-Scale Structures

NASA Technical Reports Server (NTRS)

Le, Guan; Wang, Yongli; Slavin, James A.; Strangeway, Robert J.

2007-01-01

Space Technology 5 (ST5) is a three micro-satellite constellation deployed into a 300 x 4500 km, dawn-dusk, sun-synchronous polar orbit from March 22 to June 21, 2006, for technology validations. In this paper, we present a study of the temporal variability of field-aligned currents using multi-point magnetic field measurements from ST5. The data demonstrate that meso-scale current structures are commonly embedded within large-scale field-aligned current sheets. The meso-scale current structures are very dynamic with highly variable current density and/or polarity in time scales of - 10 min. They exhibit large temporal variations during both quiet and disturbed times in such time scales. On the other hand, the data also shown that the time scales for the currents to be relatively stable are approx. 1 min for meso-scale currents and approx. 10 min for large scale current sheets. These temporal features are obviously associated with dynamic variations of their particle carriers (mainly electrons) as they respond to the variations of the parallel electric field in auroral acceleration region. The characteristic time scales for the temporal variability of meso-scale field-aligned currents are found to be consistent with those of auroral parallel electric field.

An adenylyl cyclase like-9 gene (NlAC9) influences growth and fecundity in the brown planthopper, Nilaparvata lugens (Stål) (Hemiptera: Delphacidae).

PubMed

Ge, LinQuan; Gu, HaoTian; Huang, Bo; Song, Qisheng; Stanley, David; Liu, Fang; Yang, Guo-Qing; Wu, Jin-Cai

2017-01-01

The cAMP/PKA intracellular signaling pathway is launched by adenylyl cyclase (AC) conversion of adenosine triphosphate (ATP) to 3', 5'-cyclic AMP (cAMP) and cAMP-dependent activation of PKA. Although this pathway is very well known in insect physiology, there is little to no information on it in some very small pest insects, such as the brown planthopper (BPH), Nilaparvata lugens Stål. BPH is a destructive pest responsible for tremendous crop losses in rice cropping systems. We are investigating the potentials of novel pest management technologies from RNA interference perspective. Based on analysis of transcriptomic data, the BPH AC like-9 gene (NlAC9) was up-regulated in post-mating females, which led us to pose the hypothesis that NlAC9 is a target gene that would lead to reduced BPH fitness and populations. Targeting NlAC9 led to substantially decreased soluble ovarian protein content, yeast-like symbiont abundance, and vitellogenin gene expression, accompanied with stunted ovarian development and body size. Eggs laid were decreased and oviposition period shortened. Taken together, our findings indicated that NlAC9 exerted pronounced effects on female fecundity, growth and longevity, which strongly supports our hypothesis.

The Aminolysis Reaction of Streptomyces S9 Aminopeptidase Promotes the Synthesis of Diverse Prolyl Dipeptides▿ †

PubMed Central

Arima, Jiro; Morimoto, Masazumi; Usuki, Hirokazu; Mori, Nobuhiro; Hatanaka, Tadashi

2010-01-01

Prolyl dipeptide synthesis by S9 aminopeptidase from Streptomyces thermocyaneoviolaceus (S9AP-St) has been demonstrated. In the synthesis, S9AP-St preferentially used l-Pro-OBzl as the acyl donor, yielding synthesized dipeptides having an l-Pro-Xaa structure. In addition, S9AP-St showed broad specificity toward the acyl acceptor. Furthermore, S9AP-St produced cyclo (l-Pro-l-His) with a conversion ratio of substrate to cyclo (l-Pro-l-His) higher than 40%. PMID:20418423

An Analysis of Directors' Views on Educational Technology Professional Development in 21st Century Community Learning Center Programs

ERIC Educational Resources Information Center

Bradshaw, L. Daniele

2010-01-01

The purpose of this study was to examine directors' views on the current state and needs of 2009-2010 North Carolina 21st Century Community Learning Center (21st CCLC) afterschool educational technology professional development (ETPD). The population for this study involved the 2009-2010 North Carolina 21st CCLC directors. In a mixed methods study…

Reliability and Validity of Michigan School Libraries for the 21st Century Measurement Benchmarks

ERIC Educational Resources Information Center

Floyd, Natosha N.

2016-01-01

The purpose of this study was to examine the psychometric properties of the Michigan School Libraries for the 21st Century Measurement Benchmarks (SL21). The instrument consists of 19 items with three subscales: Building the 21st Century Learning Environment Subscale, Teaching for 21st Century Learning Subscale, and Leading the Way to 21st Century…

75 FR 52982 - Notice of Determinations Regarding Eligibility To Apply for Worker Adjustment Assistance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-30

... Boeing Company, St. Louis, MO February 24, 2009. Engineering Operations, etc., Off-Site Workers Reporting to St. Louis, MO. 73,635A The Boeing Company, St. Charles, MO February 24, 2009. Engineering... 24, 2009. Engineering Operations & Technology Div. & Information Technology Div. 73,753 Lodging by...

27 CFR 9.51 - Isle St. George.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Isle St. George. 9.51... St. George. (a) Name. The name of the viticultural area described in this section is “Isle St. George.” (b) Approved maps. The approved map for determining the boundary of the Isle St. George viticultural...

21st centuries skill implication on educational system

NASA Astrophysics Data System (ADS)

Wrahatnolo, T.; Munoto

2018-01-01

The purpose of this article is to identify skill needed in 21st centuries and its implication on Indonesia’s educational system. This research found that the 21st centuries skill application has more measurable benefits in some sections of life, such as critical thinking and problem solving, initiative, creativity, and entrepreneurship, communication, teamwork, metacognition (change of mindset), digital literature. This study applied qualitative data analysis. The data were taken from different sources and literature. The analysis showed that The 21st centuries education concept’s implementation can be applied in the curriculum of the required subject that is addressed to achieve learning and innovation skills competence and also technology and information media skills competence. While supporting subject group directed to achieve life and career skills competence. All subjects are the derivation from core subject 3R, which are reading, writing, and arithmetic. Based on the description above, it can be concluded that 21st centuries skill needs; (1) a life planning; (2) flexibility and adaptability; (3) initiative and self-management (4) entrepreneurship; (5) social and cultural interaction; (6) productivity and accountability; (7) leadership; (8) critical thinking, (9) problem solving; (10) communication; (11) collaboration and teamwork; (12) lifelong learning; and (13) digital literation.

Investigating the Impact of the Cisco 21st Century Schools Initiative on Forrest County School District. Summative Report

ERIC Educational Resources Information Center

Ba, Harouna; Meade, Terri; Pierson, Elizabeth; Ferguson, Camille; Roy, Amanda; Williams, Hakim

2009-01-01

Located in southern Mississippi, the Forrest County School District (FCSD) consists of six schools: three K-6 elementary schools, two K-8 elementary-middle schools, and one high school (grades 9-12), all of which have been involved in the Cisco Initiative since its inception. The district employed 16 administrators, 7 technology staff members, and…

QuEST: Qualifying Environmentally Sustainable Technologies. Volume 2

NASA Technical Reports Server (NTRS)

Brown, Christina (Editor)

2007-01-01

TEERM focuses its validation efforts on technologies that have shown promise in laboratory testing, but lack testing under realistic or field environment. Mature technologies have advantages over those that are still in the developmental stage such as being more likely to be transitioned into a working environment. One way TEERM begins to evaluate the suitability of technologies is through Technology Readiness Levels (TRLs). TRLs are a systematic metric/measurement system that supports assessments of the maturity of a particular technology and the consistent comparison of maturity between different types of technology. TEERM generally works on demonstrating/validating alternatives that fall within TRLs 5-9. In instances where a mature technology does not exist for a particular Agency application, TEERM works with technology development groups and programs such as NASA's Innovative Partnerships Program (IPP). The IPP's purpose is to identify and document available technologies in light of NASA's needs, evaluate and prioritize those technologies, and reach out to find new partners. All TEERM projects involve multiple partners. Partnering reduces duplication of effort that otherwise might occur if individuals worked their problems alone. Partnering also helps reduce individual contributors' shares of the total cost of technology validation. Through collaboration and financial commitment from project stakeholders and third-party sources, it is possible to fully fund expensive demonstration/validation efforts.

36 CFR 7.9 - St. Croix National Scenic Rivers.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false St. Croix National Scenic Rivers. 7.9 Section 7.9 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.9 St. Croix National Scenic Rivers. (a...

Cooling Technology for Large Space Telescopes

NASA Technical Reports Server (NTRS)

DiPirro, Michael; Cleveland, Paul; Durand, Dale; Klavins, Andy; Muheim, Daniella; Paine, Christopher; Petach, Mike; Tenerelli, Domenick; Tolomeo, Jason; Walyus, Keith

2007-01-01

NASA's New Millennium Program funded an effort to develop a system cooling technology, which is applicable to all future infrared, sub-millimeter and millimeter cryogenic space telescopes. In particular, this technology is necessary for the proposed large space telescope Single Aperture Far-Infrared Telescope (SAFIR) mission. This technology will also enhance the performance and lower the risk and cost for other cryogenic missions. The new paradigm for cooling to low temperatures will involve passive cooling using lightweight deployable membranes that serve both as sunshields and V-groove radiators, in combination with active cooling using mechanical coolers operating down to 4 K. The Cooling Technology for Large Space Telescopes (LST) mission planned to develop and demonstrate a multi-layered sunshield, which is actively cooled by a multi-stage mechanical cryocooler, and further the models and analyses critical to scaling to future missions. The outer four layers of the sunshield cool passively by radiation, while the innermost layer is actively cooled to enable the sunshield to decrease the incident solar irradiance by a factor of more than one million. The cryocooler cools the inner layer of the sunshield to 20 K, and provides cooling to 6 K at a telescope mounting plate. The technology readiness level (TRL) of 7 will be achieved by the active cooling technology following the technology validation flight in Low Earth Orbit. In accordance with the New Millennium charter, tests and modeling are tightly integrated to advance the technology and the flight design for "ST-class" missions. Commercial off-the-shelf engineering analysis products are used to develop validated modeling capabilities to allow the techniques and results from LST to apply to a wide variety of future missions. The LST mission plans to "rewrite the book" on cryo-thermal testing and modeling techniques, and validate modeling techniques to scale to future space telescopes such as SAFIR.

Reliability and Validity of the Early Years Physical Activity Questionnaire (EY-PAQ)

PubMed Central

Bingham, Daniel D.; Collings, Paul J.; Clemes, Stacy A.; Costa, Silvia; Santorelli, Gillian; Griffiths, Paula; Barber, Sally E.

2016-01-01

Measuring physical activity (PA) and sedentary time (ST) in young children (<5 years) is complex. Objective measures have high validity but require specialist expertise, are expensive, and can be burdensome for participants. A proxy-report instrument for young children that accurately measures PA and ST is needed. The aim of this study was to assess the reliability and validity of the Early Years Physical Activity Questionnaire (EY-PAQ). In a setting where English and Urdu are the predominant languages spoken by parents of young children, a sample of 196 parents and their young children (mean age 3.2 ± 0.8 years) from Bradford, UK took part in the study. A total of 156 (79.6%) questionnaires were completed in English and 40 (20.4%) were completed in transliterated Urdu. A total of 109 parents took part in the reliability aspect of the study, which involved completion of the EY-PAQ on two occasions (7.2 days apart; standard deviation (SD) = 1.1). All 196 participants took part in the validity aspect which involved comparison of EY-PAQ scores against accelerometry. Validty anaylsis used all data and data falling with specific MVPA and ST boundaries. Reliability was assessed using intra-class correlations (ICC) and validity by Bland–Altman plots and rank correlation coefficients. The test re-test reliability of the EY-PAQ was moderate for ST (ICC = 0.47) and fair for moderate-to-vigorous physical activity (MVPA)(ICC = 0.35). The EY-PAQ had poor agreement with accelerometer-determined ST (mean difference = −87.5 min·day−1) and good agreement for MVPA (mean difference = 7.1 min·day−1) limits of agreement were wide for all variables. The rank correlation coefficient was non-significant for ST (rho = 0.19) and significant for MVPA (rho = 0.30). The EY-PAQ has comparable validity and reliability to other PA self-report tools and is a promising population-based measure of young children’s habitual MVPA but not ST. In situations when objective methods are not possible for measurement of young children’s MVPA, the EY-PAQ may be a suitable alternative but only if boundaries are applied.

7 CFR 93.12 - Analyses available and locations of laboratories.

Code of Federal Regulations, 2012 CFR

2012-01-01

... AMS Science and Technology (S&T) Aflatoxin Laboratories: (1) USDA, AMS, S&T 1211 Schley Avenue, Albany... Science and Technology (S&T) Aflatoxin Laboratories at Madill, Oklahoma and Blakely, Georgia will perform... matter, and oil (fat) content. (2) All of the analyses described in paragraph (b)(1) of this section...

7 CFR 93.12 - Analyses available and locations of laboratories.

Code of Federal Regulations, 2011 CFR

2011-01-01

... AMS Science and Technology (S&T) Aflatoxin Laboratories: (1) USDA, AMS, S&T 1211 Schley Avenue, Albany... Science and Technology (S&T) Aflatoxin Laboratories at Madill, Oklahoma and Blakely, Georgia will perform... matter, and oil (fat) content. (2) All of the analyses described in paragraph (b)(1) of this section...

7 CFR 93.12 - Analyses available and locations of laboratories.

Code of Federal Regulations, 2014 CFR

2014-01-01

... AMS Science and Technology (S&T) Aflatoxin Laboratories: (1) USDA, AMS, S&T 1211 Schley Avenue, Albany... Science and Technology (S&T) Aflatoxin Laboratories at Madill, Oklahoma and Blakely, Georgia will perform... matter, and oil (fat) content. (2) All of the analyses described in paragraph (b)(1) of this section...

7 CFR 93.12 - Analyses available and locations of laboratories.

Code of Federal Regulations, 2013 CFR

2013-01-01

... AMS Science and Technology (S&T) Aflatoxin Laboratories: (1) USDA, AMS, S&T 1211 Schley Avenue, Albany... Science and Technology (S&T) Aflatoxin Laboratories at Madill, Oklahoma and Blakely, Georgia will perform... matter, and oil (fat) content. (2) All of the analyses described in paragraph (b)(1) of this section...

7 CFR 93.12 - Analyses available and locations of laboratories.

Code of Federal Regulations, 2010 CFR

2010-01-01

... AMS Science and Technology (S&T) Aflatoxin Laboratories: (1) USDA, AMS, S&T 1211 Schley Avenue, Albany... Science and Technology (S&T) Aflatoxin Laboratories at Madill, Oklahoma and Blakely, Georgia will perform... matter, and oil (fat) content. (2) All of the analyses described in paragraph (b)(1) of this section...

Characterizing the Learning Curve of the VBLaST-PT© (Virtual Basic Laparoscopic Skill Trainer)

PubMed Central

Zhang, Likun; Sankaranarayanan, Ganesh; Arikatla, Venkata Sreekanth; Ahn, Woojin; Grosdemouge, Cristol; Rideout, Jesse M.; Epstein, Scott K.; De, Suvranu; Schwaitzberg, Steven D.; Jones, Daniel B.; Cao, Caroline G.L.

2013-01-01

Background and study aim Mastering laparoscopic surgical skills requires considerable time and effort. The Virtual Basic Laparoscopic Skill Trainer (VBLaST-PT©) is being developed as a computerized version of the peg transfer task of the Fundamentals of Laparoscopic Surgery (FLS) system using virtual reality technology. We assessed the learning curve of trainees on the VBLaST-PT© using the cumulative summation (CUSUM) method and compared them with those on the FLS to establish convergent validity for the VBLaST-PT©. Methods Eighteen medical students from were assigned randomly to one of three groups: control, VBLaST-training and FLS-training. The VBLaST and the FLS groups performed a total of 150 trials of the peg-transfer task over a three week period, five days a week. Their CUSUM scores were computed based on pre-defined performance criteria (junior, intermediate and senior levels). Results Of the six subjects in the VBLaST-training group, five achieved at least the “junior” level, three achieved the “intermediate” level and one achieved the “senior” level of performance criterion by the end of the 150 trials. In comparison, for the FLS group, three students achieved the “senior” criterion and all six students achieved the “intermediate” and “junior” criteria by the 150th trials. Both the VBLaST-PT© and the FLS systems showed significant skill improvement and retention, albeit with system specificity as measured by transfer of learning in the retention test: The VBLaST-trained group performed better on the VBLaST-PT© than on FLS (p=0.003), while the FLS-trained group performed better on the FLS than on VBLaST-PT© (p=0.002). Conclusion We characterized the learning curve for a virtual peg transfer task on the VBLaST-PT© and compared it with the FLS using CUSUM analysis. Subjects in both training groups showed significant improvement in skill performance, but the transfer of training between systems was not significant. PMID:23572217

Assessment of the Tobacco Dependence Screener Among Smokeless Tobacco Users.

PubMed

Mushtaq, Nasir; Beebe, Laura A

2016-05-01

Variants of the Fagerström Tolerance Questionnaire and Fagerström Test for Nicotine Dependence (FTND) are widely used to study dependence among smokeless tobacco (ST) users. However, there is a need for a dependence measure which is based on the clinical definition of dependence and is easy to administer. The Tobacco Dependence Screener (TDS), a self-administered 10-item scale, is based on the Diagnostic and Statistical Manual, fourth edition (DSM-IV) and ICD-10 definitions of dependence. It is commonly used as a tobacco dependence screening tool in cigarette smoking studies but it has not been evaluated for dependence in ST users. The purpose of this study is to evaluate the TDS as a measure of tobacco dependence among ST users. Data collected from a community-based sample of exclusive ST users living in Oklahoma (n = 95) was used for this study. TDS was adapted to be used for ST dependence as the references for smoking were changed to ST use. Concurrent validity and reliability of TDS were evaluated. Salivary cotinine concentration was used as a criterion variable. Overall accuracy of the TDS was assessed by receiver's operating characteristic (ROC) curve and optimal cutoff scores for dependence diagnosis were evaluated. There was no floor or ceiling effect in TDS score (mean = 5.42, SD = 2.61). Concurrent validity of TDS as evaluated by comparing it with FTND-ST was affirmative. Study findings showed significant association between TDS and salivary cotinine concentration. The internal consistency assessed by Cronbach's alpha indicated that TDS had acceptable reliability (α = 0.765). TDS was negatively correlated with time to first chew/dip and positively correlated with frequency (number of chews per day) and years of ST use. Results of logistic regression analysis showed that at an optimal cutoff score of TDS 5+, ST users classified as dependent had significantly higher cotinine concentration and FTND-ST scores. TDS demonstrated acceptable reliability and concurrent validity among ST users. These findings are consistent with the results of previous cigarette smoking studies evaluating TDS. A self-administered tobacco dependence measure for ST users based on a clinical definition of dependence is an effective tool in research setting. ST dependence research is still evolving. This is the first study of the TDS among ST users providing preliminary evidence about some of the psychometric properties of the scale. Similar to cigarette smokers, TDS is an effective measure of ST dependence. Study showed moderate reliability and affirmative concurrent validity of the TDS among ST users. © The Author 2015. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Experimental Validation Techniques for the Heleeos Off-Axis Laser Propagation Model

DTIC Science & Technology

2010-03-01

EXPERIMENTAL VALIDATION TECHNIQUES FOR THE HELEEOS OFF-AXIS LASER PROPAGATION MODEL THESIS John Haiducek, 1st Lt, USAF AFIT/GAP/ENP/10-M07 DEPARTMENT...Department of Defense, or the United States Government. AFIT/GAP/ENP/10-M07 EXPERIMENTAL VALIDATION TECHNIQUES FOR THE HELEEOS OFF-AXIS LASER ...BS, Physics 1st Lt, USAF March 2010 APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED. AFIT/GAP/ENP/10-M07 Abstract The High Energy Laser End-to-End

Transforming Epidemiology for 21st Century Medicine and Public Health

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khoury, Muin J; Lam, Tram Kim; Ioannidis, John

2013-01-01

n 2012, the National Cancer Institute (NCI) engaged the scientific community to provide a vision for cancer epidemiology in the 21st century. Eight overarching thematic recommendations, with proposed corresponding actions for consideration by funding agencies, professional societies, and the research community emerged from the collective intellectual discourse. The themes are (i) extending the reach of epidemiology beyond discovery and etiologic research to include multilevel analysis, intervention evaluation, implementation, and outcomes research; (ii) transforming the practice of epidemiology by moving toward more access and sharing of protocols, data, metadata, and specimens to foster collaboration, to ensure reproducibility and replication, and acceleratemore » translation; (iii) expanding cohort studies to collect exposure, clinical, and other information across the life course and examining multiple health-related endpoints; (iv) developing and validating reliable methods and technologies to quantify exposures and outcomes on a massive scale, and to assess concomitantly the role of multiple factors in complex diseases; (v) integrating big data science into the practice of epidemiology; (vi) expanding knowledge integration to drive research, policy, and practice; (vii) transforming training of 21st century epidemiologists to address interdisciplinary and translational research; and (viii) optimizing the use of resources and infrastructure for epidemiologic studies. These recommendations can transform cancer epidemiology and the field of epidemiology, in general, by enhancing transparency, interdisciplinary collaboration, and strategic applications of new technologies. They should lay a strong scientific foundation for accelerated translation of scientific discoveries into individual and population health benefits.« less

Transforming Epidemiology for 21st Century Medicine and Public Health

PubMed Central

Khoury, Muin J.; Lam, Tram Kim; Ioannidis, John P.A.; Hartge, Patricia; Spitz, Margaret R.; Buring, Julie E.; Chanock, Stephen J.; Croyle, Robert T.; Goddard, Katrina A.; Ginsburg, Geoffrey S.; Herceg, Zdenko; Hiatt, Robert A.; Hoover, Robert N.; Hunter, David J.; Kramer, Barnet S.; Lauer, Michael S.; Meyerhardt, Jeffrey A.; Olopade, Olufunmilayo I.; Palmer, Julie R.; Sellers, Thomas A.; Seminara, Daniela; Ransohoff, David F.; Rebbeck, Timothy R.; Tourassi, Georgia; Winn, Deborah M.; Zauber, Ann; Schully, Sheri D.

2013-01-01

In 2012, the National Cancer Institute (NCI) engaged the scientific community to provide a vision for cancer epidemiology in the 21st century. Eight overarching thematic recommendations, with proposed corresponding actions for consideration by funding agencies, professional societies, and the research community emerged from the collective intellectual discourse. The themes are (i) extending the reach of epidemiology beyond discovery and etiologic research to include multilevel analysis, intervention evaluation, implementation, and outcomes research; (ii) transforming the practice of epidemiology by moving towards more access and sharing of protocols, data, metadata, and specimens to foster collaboration, to ensure reproducibility and replication, and accelerate translation; (iii) expanding cohort studies to collect exposure, clinical and other information across the life course and examining multiple health-related endpoints; (iv) developing and validating reliable methods and technologies to quantify exposures and outcomes on a massive scale, and to assess concomitantly the role of multiple factors in complex diseases; (v) integrating “big data” science into the practice of epidemiology; (vi) expanding knowledge integration to drive research, policy and practice; (vii) transforming training of 21st century epidemiologists to address interdisciplinary and translational research; and (viii) optimizing the use of resources and infrastructure for epidemiologic studies. These recommendations can transform cancer epidemiology and the field of epidemiology in general, by enhancing transparency, interdisciplinary collaboration, and strategic applications of new technologies. They should lay a strong scientific foundation for accelerated translation of scientific discoveries into individual and population health benefits. PMID:23462917

A Case Study Exploring Technology Integration and Incorporation of 21st Century Skills in Elementary Classrooms

ERIC Educational Resources Information Center

Louis, Rebekah C.

2012-01-01

As the abundance and importance of technology continues to increase, schools are attempting to stay current by utilizing technology educationally. While the technology at many schools is plentiful, few teachers are able to effectively integrate technology in their daily lessons in a meaningful way, equipping students with the 21st century skills…

21st Century Cell Culture for 21st Century Toxicology.

PubMed

Pamies, David; Hartung, Thomas

2017-01-17

There is no good science in bad models. Cell culture is especially prone to artifacts. A number of novel cell culture technologies have become more broadly available in the 21st century, which allow overcoming limitations of traditional culture and are more physiologically relevant. These include the use of stem-cell derived human cells, cocultures of different cell types, scaffolds and extracellular matrices, perfusion platforms (such as microfluidics), 3D culture, organ-on-chip technologies, tissue architecture, and organ functionality. The physiological relevance of such models is further enhanced by the measurement of biomarkers (e.g., key events of pathways), organ specific functionality, and more comprehensive assessment cell responses by high-content methods. These approaches are still rarely combined to create microphysiological systems. The complexity of the combination of these technologies can generate results closer to the in vivo situation but increases the number of parameters to control, bringing some new challenges. In fact, we do not argue that all cell culture needs to be that sophisticated. The efforts taken are determined by the purpose of our experiments and tests. If only a very specific molecular target to cell response is of interest, a very simple model, which reflects this, might be much more suited to allow standardization and high-throughput. However, the less defined the end point of interest and cellular response are, the better we should approximate organ- or tissue-like culture conditions to make physiological responses more probable. Besides these technologic advances, important progress in the quality assurance and reporting on cell cultures as well as the validation of cellular test systems brings the utility of cell cultures to a new level. The advancement and broader implementation of Good Cell Culture Practice (GCCP) is key here. In toxicology, this is a major prerequisite for meaningful and reliable results, ultimately supporting risk assessment and product development decisions.

46 CFR 45.183 - Load line requirements for the St. Joseph and Muskegon routes.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Load line requirements for the St. Joseph and Muskegon... requirements for the St. Joseph and Muskegon routes. (a) Load line certificate. (1) The load line issued under... certificate is valid for the St. Joseph and Muskegon routes, and intermediate ports. However, operators must...

Aerospace Technologies of the 21st Century: New Technologies of Experimental Research and Simulation Held in Berlin, Germany on 8-9 June 2000

DTIC Science & Technology

2000-01-01

11. Gal-Or, B., U.S. PAT. Appl .. 08/516870/1, Aug. 18, 1995 & Isr. Pat. Appl . 113636, May 7,1995 by Gal- Or, Lichtsinder and Sherbaum.. 12. Gal-Or...B., U.S. PAT. Appl . 08/516870/2, Aug. 18, 1995 & Isr. Pat. Appl . 111265, Oct. 12,94 by Gal- Or, Lichtsinder and Sherbaum. 13. Gal-Or, B., U.S. PAT... Appl . 08/554087, Nov. 6,1995. 14. Gal-Or, B., ?Proposed Flight Testing Standards for Engine Thrust Vectoring to Maximize Kill Ra- tios, Post-Stall

75 FR 33631 - Science and Technology (S&T) Directorate; Agency Information Collection Activities: Submission...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-14

... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2010-0040] Science and Technology (S&T) Directorate; Agency Information Collection Activities: Submission for Review; Information Collection Request for the Department of Homeland Security (DHS) Science and Technology TechSolutions Program AGENCY...

75 FR 53706 - Science and Technology (S&T) Directorate: Agency Information Collection Activities: Submission...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-01

... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2010-0072] Science and Technology (S&T) Directorate: Agency Information Collection Activities: Submission for Review; Information Collection Request for the Department of Homeland Security (DHS) Science and Technology TechSolutions Program AGENCY...

Annual Science and Technology Report to the Congress: 1982.

ERIC Educational Resources Information Center

Office of Science and Technology Policy, Washington, DC.

This report provides a comprehensive statement of the Reagan administration's science and technology (S/T) policy and priorities. The report is organized into three chapters. Chapter I discusses S/T and United States society and the United States S/T policy. Highlights of the 1982 accomplishments in implementing the policy and of the fiscal year…

In Situ Chemical Oxidation for Groundwater Remediation: Site-Specific Engineering & Technology Application

DTIC Science & Technology

2010-10-01

PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Colorado School of Mines,1500 Illinois St, Golden ,CO,80401 8. PERFORMING ORGANIZATION REPORT NUMBER 9...Protocol page 13 Overall ISCO Protocol Flow Diagram addition, laboratory studies may be used to select optimal chemistry parameters to maximize oxidant...Design Process 5. Because of the complexity of these oxidants’ chemistry and implementation, with much of the knowledge base residing with those

Nanostructures: Physics and Technology International Symposium (9th), St. Petersburg, Russia, June 18-22, 2001 Proceedings

DTIC Science & Technology

2001-06-22

detection: SThM operates because of heat extending into the microfabricated thermocouple. Therefore, the nature of the thermal contact between tip and...local heating phenomena . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 202 ix NC.05 Yu. V. Dubrovskii, A. Patane, P. N... heating . During the growth process the rotation of the samples is used, temperature field inhomogenity across the surface is about ∼ 5%. In order to

META II Complexity and Adaptability

DTIC Science & Technology

2011-08-01

NUMBER 62303E 6. AUTHOR( S ) Douglas Stuart and Raju Mattikalli 5d. PROJECT NUMBER DM30 5e. TASK NUMBER 01 5f. WORK UNIT NUMBER DM300104 7...PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION The Boeing Company Boeing Research and Technology P.O. Box 516 St...Louis, MO 63166-0516 REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME( S ) AND ADDRESS(ES) 10. SPONSORING/MONITORING Air Force Research

Subtype analysis of Blastocystis sp. isolates from human and canine hosts in an urban community in the Philippines.

PubMed

Belleza, Maria Luz B; Reyes, John Carlo B; Tongol-Rivera, Pilarita N; Rivera, Windell L

2016-06-01

Blastocystis sp. is a common gut-dwelling protist of both humans and animals. A cross-sectional survey among humans and their dogs was conducted to determine the prevalence of Blastocystis infection and to characterize the subtype (ST) distribution in an urban community in the Philippines. Fecal specimens from 1,271 humans and 145 dogs were collected and inoculated in diphasic culture medium. Prevalence of Blastocystis by culture was 13.0% (95% CI = 11.2-15.0) and 14.5% (95% CI = 9.6-21.2) for humans and dogs, respectively. A total of 168 culture isolates were genotyped using polymerase chain reaction (PCR) with seven pairs of ST-specific sequence-tagged-site (STS) primers. In humans, the ST present in this study were ST1 with 22.6% (95% CI = 17.2-29.0), ST2 with 3.1% (95% CI = 1.3-6.7), ST3 with 41.4% (95% CI= 34.9-48.6), ST4 with 14.8% (95% CI = 10.5-20.6), ST5 with 4.1% (95% CI = 2.0-8.0), and unknown ST with 13.9% (95% CI = 9.6-19.4). In dogs, the ST present in this study were ST1 with 4.3% (95% CI = 0.0-29.0), ST2 with 8.7% (95% CI = 1.3-28.0), ST3 with 17.4% (95% CI = 6.4-37.7), ST4 with 13.0% (95% CI = 3.7-33.0), ST5 with 13.0% (95% CI = 3.7-33.0), and unknown ST with 47.8% (95% CI = 29.2-67.0). This is the first study that reported Blastocystis ST4 in human and canine hosts in the Philippines. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Molecular Characteristics of Staphylococcus aureus Causing Bovine Mastitis between 2014 and 2015.

PubMed

Li, Tianming; Lu, Huiying; Wang, Xing; Gao, Qianqian; Dai, Yingxin; Shang, Jun; Li, Min

2017-01-01

Staphylococcus aureus is highly pathogenic and can cause diseases in both humans and domestic animals. In animal species, including ruminants, S. aureus may cause severe or sub-clinical mastitis. This study aimed to investigate the molecular profile, antimicrobial resistance, and genotype/phenotype correlation of 212 S. aureus isolates recovered from cases of bovine mastitis from 2014 to 2015 in the Shanghai and Zhejiang areas of China. Nineteen sequence types (STs) were determined by multi-locus sequence typing, while the dominant ST was ST97, followed by ST520, ST188, ST398, ST7, and ST9. Within 14 methicillin-resistant S. aureus (MRSA) isolates and 198 methicillin-susceptible S. aureus (MSSA) isolates, ST97 was the predominant MSSA clone and ST9-MRSA-SCCmecXII-spa t899 was the most common MRSA clone. The MRSA strains showed much higher rates of resistance to multiple antibiotics than did MSSA strains. Compared with other MSSA strains, MSSA ST398 was more resistant to clindamycin, erythromycin, and ciprofloxacin. No isolates were resistant to vancomycin, teicoplanin, or linezolid. The molecular profiles of the virulence genes varied in different strains. ST520 strains carried seg-sei-sem-sen-seo genes, and ST9 and ST97 harbored sdrD-sdrE genes. Virulence phenotype analysis showed diversity in different clones. Biofilm formation ability was significantly enhanced in ST188 and ST7, and red blood cell lysis capacity was relatively strong in all S. aureus strains of animal origin except ST7. Our results indicate that MSSA was the predominant S. aureus strain causing bovine mastitis in eastern regions of China. However, the presence of multidrug resistant and toxigenic MRSA clone ST9 suggests that comprehensive surveillance of S. aureus infection should be implemented in the management of animal husbandry products.

Preparing Preservice Teachers for 21st Century Classrooms: Transforming Attitudes and Behaviors about Innovative Technology

ERIC Educational Resources Information Center

Williams, Mia Kim; Foulger, Teresa S.; Wetzel, Keith

2009-01-01

Keeping-up with progressing technology tools has been a troublesome issue for educational technology instructors for over ten years as they endeavor to prepare beginning teachers to integrate technology in their future classrooms. This paper promotes instructors' ideas about behaviors of 21st century teachers, and explores efforts to support their…

New assessment of endothelial function measured by short time flow-mediated vasodilation: Comparison with conventional flow-mediated vasodilation measurement.

PubMed

Matsui, Shogo; Kajikawa, Masato; Maruhashi, Tatsuya; Hashimoto, Haruki; Kihara, Yasuki; Chayama, Kazuaki; Goto, Chikara; Aibara, Yoshiki; Yusoff, Farina Mohamad; Kishimoto, Shinji; Nakashima, Ayumu; Noma, Kensuke; Kawaguchi, Tomohiro; Matsumoto, Takeo; Higashi, Yukihito

2018-05-04

Measurement of flow-mediated vasodilation (FMD) is an established method for assessing endothelial function. Measurement of FMD is useful for showing the relationship between atherosclerosis and endothelial function, mechanisms of endothelial dysfunction, and clinical implications including effects of interventions and cardiovascular events. To shorten and simplify the measurement of FMD, we have developed a novel technique named short time FMD (stFMD). We investigated the validity of stFMD for assessment of endothelial function compared with conventional FMD. We evaluated stFMD and conventional FMD in 82 subjects including patients with atherosclerotic risk factors and cardiovascular disease (66 men and 16 women, 57 ± 16 years). Both stFMD and conventional FMD were significantly correlated with age, systolic blood pressure, diastolic blood pressure and baseline brachial artery diameter. In addition, stFMD was significantly correlated with conventional FMD (r = 0.76, P < 0.001). Bland-Altman plot analysis showed good agreement between stFMD and conventional FMD. Moreover, stFMD in the at risk group and that in the cardiovascular disease group were significantly lower than that in the no risk group (4.6 ± 2.3% and 4.4 ± 2.2% vs. 7.3 ± 1.9%, P < 0.001, respectively). Optimal cutoff value of stFMD for diagnosing atherosclerosis was 7.0% (sensitivity of 71.0% and specificity of 85.0%). These findings suggest that measurement of stFMD, a novel and simple method, is useful for assessing endothelial function. Measurement of stFMD may be suitable for screening of atherosclerosis when repeated measurements of vascular function are required and when performing a clinical trial using a large population. URL for Clinical Trial: http://UMIN; Registration Number for Clinical Trial: UMIN000025458. Copyright © 2017 Elsevier B.V. All rights reserved.

21st Space Simulation Conference: The Future of Space Simulation Testing in the 21st Century

NASA Technical Reports Server (NTRS)

Stecher, Joseph L., III (Compiler)

2000-01-01

The Institute of Environmental Sciences and Technology's Twenty-first Space Simulation Conference, "The Future of Space Testing in the 21st Century" provided participants with a forum to acquire and exchange information on the state-of-the-art in space simulation, test technology, atomic oxygen, programs/system testing, dynamics testing, contamination, and materials. The papers presented at this conference and the resulting discussions carried out the conference theme "The Future of Space Testing in the 21st Century."

Clinical impact and predictors of complete ST segment resolution after primary percutaneous coronary intervention: A subanalysis of the ATLANTIC Trial.

PubMed

Fabris, Enrico; van 't Hof, Arnoud; Hamm, Christian W; Lapostolle, Frédéric; Lassen, Jens F; Goodman, Shaun G; Ten Berg, Jurriën M; Bolognese, Leonardo; Cequier, Angel; Chettibi, Mohamed; Hammett, Christopher J; Huber, Kurt; Janzon, Magnus; Merkely, Béla; Storey, Robert F; Zeymer, Uwe; Cantor, Warren J; Tsatsaris, Anne; Kerneis, Mathieu; Diallo, Abdourahmane; Vicaut, Eric; Montalescot, Gilles

2017-08-01

In the ATLANTIC (Administration of Ticagrelor in the catheterization laboratory or in the Ambulance for New ST elevation myocardial Infarction to open the Coronary artery) trial the early use of aspirin, anticoagulation, and ticagrelor coupled with very short medical contact-to-balloon times represent good indicators of optimal treatment of ST-elevation myocardial infarction and an ideal setting to explore which factors may influence coronary reperfusion beyond a well-established pre-hospital system. This study sought to evaluate predictors of complete ST-segment resolution after percutaneous coronary intervention in ST-elevation myocardial infarction patients enrolled in the ATLANTIC trial. ST-segment analysis was performed on electrocardiograms recorded at the time of inclusion (pre-hospital electrocardiogram), and one hour after percutaneous coronary intervention (post-percutaneous coronary intervention electrocardiogram) by an independent core laboratory. Complete ST-segment resolution was defined as ≥70% ST-segment resolution. Complete ST-segment resolution occurred post-percutaneous coronary intervention in 54.9% ( n=800/1456) of patients and predicted lower 30-day composite major adverse cardiovascular and cerebrovascular events (odds ratio 0.35, 95% confidence interval 0.19-0.65; p<0.01), definite stent thrombosis (odds ratio 0.18, 95% confidence interval 0.02-0.88; p=0.03), and total mortality (odds ratio 0.43, 95% confidence interval 0.19-0.97; p=0.04). In multivariate analysis, independent negative predictors of complete ST-segment resolution were the time from symptoms to pre-hospital electrocardiogram (odds ratio 0.91, 95% confidence interval 0.85-0.98; p<0.01) and diabetes mellitus (odds ratio 0.6, 95% confidence interval 0.44-0.83; p<0.01); pre-hospital ticagrelor treatment showed a favorable trend for complete ST-segment resolution (odds ratio 1.22, 95% confidence interval 0.99-1.51; p=0.06). This study confirmed that post-percutaneous coronary intervention complete ST-segment resolution is a valid surrogate marker for cardiovascular clinical outcomes. In the current era of ST-elevation myocardial infarction reperfusion, patients' delay and diabetes mellitus are independent predictors of poor reperfusion and need specific attention in the future.

Infusing Creativity and Technology in 21st Century Education: A Systemic View for Change

ERIC Educational Resources Information Center

Henriksen, Danah; Mishra, Punya; Fisser, Petra

2016-01-01

In this article, we explore creativity alongside educational technology, as fundamental constructs of 21st century education. Creativity has become increasingly important, as one of the most important and noted skills for success in the 21st century. We offer a definition of creativity; and draw upon a systems model of creativity, to suggest…

Developing the 21st-Century Social Studies Skills through Technology Integration

ERIC Educational Resources Information Center

Farisi, Mohammad Imam

2016-01-01

Recently, technology has become an educational necessity in global-digital era. Facing these phenomena, social studies (SS) should make innovations related to changes of 21st-century skills and learning paradigm, which is characterized by the principles of disclosure of information, computing, automation, and communication. Technology integration…

Augmenting the impact of technology adoption with financial incentive to improve radiology report signature times.

PubMed

Andriole, Katherine P; Prevedello, Luciano M; Dufault, Allen; Pezeshk, Parham; Bransfield, Robert; Hanson, Richard; Doubilet, Peter M; Seltzer, Steven E; Khorasani, Ramin

2010-03-01

Radiology report signature time (ST) can be a substantial component of total report turnaround time. Poor turnaround time resulting from lengthy ST can adversely affect patient care. The combination of technology adoption with financial incentive was evaluated to determine if ST improvement can be augmented and sustained. This prospective study was performed at a 751-bed, urban, tertiary care adult teaching hospital. Test-site imaging volume approximated 48,000 examinations per month. The radiology department has 100 trainees and 124 attending radiologists serving multiple institutions. Over a study period of 4 years and 4 months, three interventions focused on radiologist signature performance were implemented: 1) a notification paging application that alerted radiologists when reports were ready for signature, 2) a picture archiving and communications systems (PACS)-integrated speech recognition report generation system, and 3) a departmental financial incentive to reward radiologists semiannually for ST performance. Signature time was compared before and after the interventions. Wilcoxon and linear regression statistical analyses were used to assess the significance of trends. Technology adoption (paging plus speech recognition) reduced median ST from >5 to <1 hour (P < .001) and 80th-percentile ST from >24 to 15 to 18 hours (P < .001). Subsequent addition of a financial incentive further improved 80th-percentile ST to 4 to 8 hours (P < .001). The gains in median and 80th-percentile ST were sustained over the final 31 months of the study period. Technology interventions coupled with financial incentive can result in synergistic and sustainable improvement in radiologist report-signing behavior. The addition of a financial incentive leads to better performance than that achievable through technology alone.

Validity and reliability of the BOD POD® S/T tracking system.

PubMed

Tseh, W; Caputo, J L; Keefer, D J

2010-10-01

BOD POD(®) self-testing (S/T) body composition tracking system is a practical assessment tool designed for use in the health and fitness industries. Relative to its parent counterpart, the BOD POD(®) S/T has received little research attention. The primary purpose was to determine the validity of the BOD POD(®) S/T against hydrostatic weighing and 7-site skinfolds. Secondary aim was to determine the within-day and between-day reliability of the BOD POD(®) S/T. After a period of equipment and testing accommodation, volunteer's (N=50) body composition (%BF) via 7-site skinfolds, BOD POD(®) S/T, and hydrostatic weighing were obtained on the second and third visits. BOD POD(®) S/T significantly overestimated %BF when compared to hydrostatic weighing and 7-site skinfolds. There was no statistical difference between 7-site skinfolds and hydrostatic weighing values. BOD POD(®) S/T reliability within-day and between-days were high. While the BOD POD(®) S/T body composition tracking system is deemed reliable both within-day and between-days, it did significantly overestimate %BF in comparison to hydrostatic weighing and skinfolds. Future research should be aimed at deriving a correction factor for this body composition assessment tool. © Georg Thieme Verlag KG Stuttgart · New York.

Strategic latency and warning. Private sector perspectives on current intelligence challenges in science and technology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davis, Zachary; Gac, Frank; Nacht, Michael

Lawrence Livermore National Laboratory and National Intelligence University convened a group of business experts to examine parallels between S&T competition in the marketplace and science and technology intelligence (S&TI). The experts identified the centrality of people — individuals and connected groups — to the successful development and application of latent S&T capabilities. People may indeed be more important to recognizing S&T potential than deep knowledge of any particular technology. This report explores the significance of this key insight for S&TI.

Joint U.S. Defense Science Board, UK Defence Scientific Advisory Council Task Force on Defense Critical Technologies

DTIC Science & Technology

2006-03-01

electrons (e.g., betavoltaics ) in a compact package is emerging as a possible new high energy density power source. Proliferation is not an issue...10 13 10 12 10 11 10 10 10 9 10 8 10 7 10 6 10 5 10 2 10 3 10 4 10 5 10 6 10 7 Total Dose [rad) Si )] Strategic Space Strategic Missiles St ra te gi

Measuring Psychobiosocial States in Sport: Initial Validation of a Trait Measure

PubMed Central

Bertollo, Maurizio; Ruiz, Montse C.; Bortoli, Laura

2016-01-01

We examined the item characteristics, the factor structure, and the concurrent validity of a trait measure of psychobiosocial states. In Study 1, Italian athletes (N = 342, 228 men, 114 women, Mage = 23.93, SD = 6.64) rated the intensity, the frequency, and the perceived impact dimensions of a psychobiosocial states scale, trait version (PBS-ST), which is composed of 20 items (10 functional and 10 dysfunctional) referring to how they usually felt before an important competition. In Study 2, the scale was cross validated in an independent sample (N = 251, 181 men, 70 women, Mage = 24.35, SD = 7.25). The concurrent validity of the PBS-ST scale scores were also examined in comparison with two sport-specific emotion-related measures and a general measure of affect. Exploratory structural equation modeling and confirmatory factor analysis of the data of Study 1 showed that a 2-factor, 15-item solution of the PBS-ST scale (8 functional items and 7 dysfunctional items) reached satisfactory fit indices for the three dimensions (i.e., intensity, frequency, and perceived impact). Results of Study 2 provided evidence of substantial measurement and structural invariance of all dimensions across samples. The low association of the PBS-ST scale with other measures suggests that the scale taps unique constructs. Findings of the two studies offer initial validity evidence for a sport-specific tool to measure psychobiosocial states. PMID:27907111

Gender Differences in Attitudes Toward Science and Technology Among Majors

NASA Astrophysics Data System (ADS)

Gokhale, Anu A.; Rabe-Hemp, Cara; Woeste, Lori; Machina, Kenton

2015-08-01

In the USA, women have consistently been proportionally underrepresented in science and technology (S&T). In these disciplines, as students move from high schools to colleges to graduate programs, qualified women drop out at higher rates than do men, resulting in a striking loss of talented students. Attitude toward a discipline is one of the major factors in students' choice of majors. As a result, attitudes toward S&T are issues with longstanding attention and interest in education research. Retention of female students in S&T majors remains a major concern. The purpose of the study was to investigate attitudes toward S&T including attitudes toward female participation in S&T, among S&T majors, and examine differences by gender and class standing. Such an investigation would provide deeper insights to help devise strategies to retain women in S&T majors.

The Availability and Use of 21st Century Technology Tools in South Carolina Secondary Public School Library Media Centers

ERIC Educational Resources Information Center

DuRant, Kathleen D.

2010-01-01

The purpose of this study was to assess the readiness of South Carolina secondary school library media specialists to prepare students to meet the "AASL Standards for the 21st Century Learner" (American Association of School Librarians, 2009b) by investigating the availability of 21st century technology tools, the confidence level of…

Technology Education for the 21st Century: A Collection of Essays. 49th Yearbook, 2000.

ERIC Educational Resources Information Center

Martin, G. Eugene, Ed.

These 38 essays in 4 units are directed toward the future of technology education. Unit I: Evolving into the 21st Century has one essay, entitled "The Past Defines the Paths to be Taken" (Jerry Streichler). Essays 2-18, in Unit II: Exemplary Practices for the 21st Century, are "Developing a Curriculum Process" (Bryan Albrecht);…

Validation of clinical testing for warfarin sensitivity: comparison of CYP2C9-VKORC1 genotyping assays and warfarin-dosing algorithms.

PubMed

Langley, Michael R; Booker, Jessica K; Evans, James P; McLeod, Howard L; Weck, Karen E

2009-05-01

Responses to warfarin (Coumadin) anticoagulation therapy are affected by genetic variability in both the CYP2C9 and VKORC1 genes. Validation of pharmacogenetic testing for warfarin responses includes demonstration of analytical validity of testing platforms and of the clinical validity of testing. We compared four platforms for determining the relevant single nucleotide polymorphisms (SNPs) in both CYP2C9 and VKORC1 that are associated with warfarin sensitivity (Third Wave Invader Plus, ParagonDx/Cepheid Smart Cycler, Idaho Technology LightCycler, and AutoGenomics Infiniti). Each method was examined for accuracy, cost, and turnaround time. All genotyping methods demonstrated greater than 95% accuracy for identifying the relevant SNPs (CYP2C9 *2 and *3; VKORC1 -1639 or 1173). The ParagonDx and Idaho Technology assays had the shortest turnaround and hands-on times. The Third Wave assay was readily scalable to higher test volumes but had the longest hands-on time. The AutoGenomics assay interrogated the largest number of SNPs but had the longest turnaround time. Four published warfarin-dosing algorithms (Washington University, UCSF, Louisville, and Newcastle) were compared for accuracy for predicting warfarin dose in a retrospective analysis of a local patient population on long-term, stable warfarin therapy. The predicted doses from both the Washington University and UCSF algorithms demonstrated the best correlation with actual warfarin doses.

Cyber Portfolio: The Innovative Menu for 21st Century Technology

ERIC Educational Resources Information Center

Robles, Ava Clare Marie O.

2012-01-01

Cyber portfolio is a valuable innovative menu for teachers who seek out strategies or methods to integrate technology into their lessons. This paper presents a straightforward preparation on how to innovate a menu that addresses the 21st century skills blended with higher order thinking skills, multiple intelligence, technology and multimedia.…

Construct validity of the Heart Failure Screening Tool (Heart-FaST) to identify heart failure patients at risk of poor self-care: Rasch analysis.

PubMed

Reynolds, Nicholas A; Ski, Chantal F; McEvedy, Samantha M; Thompson, David R; Cameron, Jan

2018-02-14

The aim of this study was to psychometrically evaluate the Heart Failure Screening Tool (Heart-FaST) via: (1) examination of internal construct validity; (2) testing of scale function in accordance with design; and (3) recommendation for change/s, if items are not well adjusted, to improve psychometric credential. Self-care is vital to the management of heart failure. The Heart-FaST may provide a prospective assessment of risk, regarding the likelihood that patients with heart failure will engage in self-care. Psychometric validation of the Heart-FaST using Rasch analysis. The Heart-FaST was administered to 135 patients (median age = 68, IQR = 59-78 years; 105 males) enrolled in a multidisciplinary heart failure management program. The Heart-FaST is a nurse-administered tool for screening patients with HF at risk of poor self-care. A Rasch analysis of responses was conducted which tested data against Rasch model expectations, including whether items serve as unbiased, non-redundant indicators of risk and measure a single construct and that rating scales operate as intended. The results showed that data met Rasch model expectations after rescoring or deleting items due to poor discrimination, disordered thresholds, differential item functioning, or response dependence. There was no evidence of multidimensionality which supports the use of total scores from Heart-FaST as indicators of risk. Aggregate scores from this modified screening tool rank heart failure patients according to their "risk of poor self-care" demonstrating that the Heart-FaST items constitute a meaningful scale to identify heart failure patients at risk of poor engagement in heart failure self-care. © 2018 John Wiley & Sons Ltd.

Tungsten wire/FeCrAlY matrix turbine blade fabrication study

NASA Technical Reports Server (NTRS)

Melnyk, P.; Fleck, J. N.

1979-01-01

The objective was to establish a viable FRS monotape technology base to fabricate a complex, advanced turbine blade. All elements of monotape fabrication were addressed. A new process for incorporation of the matrix, including bi-alloy matrices, was developed. Bonding, cleaning, cutting, sizing, and forming parameters were established. These monotapes were then used to fabricate a 48 ply solid JT9D-7F 1st stage turbine blade. Core technology was then developed and first a 12 ply and then a 7 ply shell hollow airfoil was fabricated. As the fabrication technology advanced, additional airfoils incorporated further elements of sophistication, by introducing in sequence bonded root blocks, cross-plying, bi-metallic matrix, tip cap, trailing edge slots, and impingement inserts.

Increased risk of large-for-gestational age birthweight in singleton siblings conceived with in vitro fertilization in frozen versus fresh cycles.

PubMed

Luke, Barbara; Brown, Morton B; Wantman, Ethan; Stern, Judy E; Toner, James P; Coddington, Charles C

2017-02-01

Children born from fresh in vitro fertilization (IVF) cycles are at greater risk of being born smaller and earlier, even when limited to singletons; those born from frozen cycles have an increased risk of large-for-gestational age (LGA) birthweight (z-score ≥1.28). This analysis sought to overcome limitations in other studies by using pairs of siblings, and accounting for prior cycle outcomes, maternal characteristics, and embryo state and stage. Pairs of singleton births conceived with IVF and born between 2004 and 2013 were identified from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database, matched for embryo stage (blastocyst versus non-blastocyst) and infant gender, categorized by embryo state (fresh versus frozen) in 1st and 2nd births (four groups). The data included 7795 singleton pairs. Birthweight z-scores were 0.00-0.04 and 0.24-0.26 in 1st and 2nd births in fresh cycles, and 0.25-0.34 and 0.50-0.55 in frozen cycles, respectively. LGA was 9.2-9.8 and 14.2-15.4% in 1st and 2nd births in fresh cycles, and 13.1-15.8 and 20.8-21.0% in 1st and 2nd births in frozen cycles. The risk of LGA was increased in frozen cycles (1st births, adjusted odds ratios (AOR) 1.74, 95% CI 1.45, 2.08; and in 2nd births when the 1st birth was not LGA, AOR 1.70, 95% CI 1.46, 1.98 for fresh/frozen and 1.40, 1.11, 1.78 for frozen/frozen). Our results with siblings indicate that frozen embryo state is associated with an increased risk for LGA. The implications of these findings for childhood health and risk of obesity are unclear, and warrant further investigation.

Space Technology 7 Disturbance Reduction System - precision control flight Validation

NASA Technical Reports Server (NTRS)

Carmain, Andrew J.; Dunn, Charles; Folkner, William; Hruby, Vlad; Spence, Doug; O'Donnell, James; Markley, Landis; Maghami, Peiman; Hsu, Oscar; Demmons, N.;

Validation of the AFIT Small Scale Combustion Facility and OH Laser-Induced Fluorescence of an Atmospheric Laminar Premixed Flame

DTIC Science & Technology

2007-09-01

this means excitation will occur in the (1,0) vibrational band in the A- X electronic system. 50 Recalling Fig. 6b, light is emitted at the...spectra in Fig. 40. Fig. 40. OH emission spectra at T = 2300 K The emission spectra in Fig. 40 has the same (0,0) and (1,0) vibrational bands...51st ASME International Gas Turbine and Aeroengine Congress and Exposition, GT2006-90119, Barcelona, Spain: May 2006 9. Roquermore, W.M., Dale

Towards Virtual FLS: Development of a Peg Transfer Simulator

PubMed Central

Arikatla, Venkata S; Ahn, Woojin; Sankaranarayanan, Ganesh; De, Suvranu

2014-01-01

Background Peg transfer is one of five tasks in the Fundamentals of Laparoscopic Surgery (FLS), program. We report the development and validation of a Virtual Basic Laparoscopic Skill Trainer-Peg Transfer (VBLaST-PT©) simulator for automatic real-time scoring and objective quantification of performance. Methods We have introduced new techniques in order to allow bi-manual manipulation of pegs and automatic scoring/evaluation while maintaining high quality of simulation. We performed a preliminary face and construct validation study with 22 subjects divided into two groups: experts (PGY 4–5, fellow and practicing surgeons) and novice (PGY 1–3). Results Face validation shows high scores for all the aspects of the simulation. A two-tailed Mann-Whitney U-test scores showed significant difference between the two groups on completion time (p=0.003), FLS score (p=0.002) and the VBLaST-PT© score (p=0.006). Conclusions VBLaST-PT© is a high quality virtual simulator that showed both face and construct validity. PMID:24030904

Classroom Technology Integration: A Comparative Study of Participants and Non-Participants in the 21st Century Model Classroom Program

ERIC Educational Resources Information Center

McDowell, Darrell Grady

2013-01-01

This study provided a unique opportunity to examine how two groups of teachers experienced the integration of technology in a K-12 school system in the southeastern United States. The total number of respondents (n = 338) included 21st Century Model Classroom (CMC) program teachers (n = 27) and non-participants (n = 311). Teachers in the 21st CMC…

Gypsum

USGS Publications Warehouse

Crangle, R.D.

2013-01-01

The United States is the world’s fifth ranked producer and consumer of gypsum. Production of crude gypsum in the United States during 2012 was estimated to be 9.9 Mt (10.9 million st), an increase of 11 percent compared with 2011 production. The average price of mined crude gypsum was $7/t ($6.35/st). Synthetic gypsum production in 2012, most of which is generated as a flue-gas desulphurization product from coal-fired electric powerplants, was estimated to be 11.8 Mt (13 million st) and priced at approximately $1.50/t ($1.36/st). Forty-seven companies produced gypsum in the United States at 54 mines and plants in 34 states. U.S. gypsum exports totaled 408 kt (450,000 st). Imports were much higher at 3.2 Mt (3.5 million st).

Drag-Free Performance of the ST7 Disturbance Reduction System Flight Experiment on the LISA Pathfinder

NASA Technical Reports Server (NTRS)

Maghami, Peiman; O'Donnell, James, Jr.; Hsu, Oscar; Ziemer, John; Dunn, Charles

2017-01-01

The Space Technology-7 Disturbance Reduction System (DRS) is an experiment package aboard the European Space Agency (ESA) LISA Pathfinder spacecraft. LISA Pathfinder launched from Kourou, French Guiana on December 3, 2015. The DRS is tasked to validate two specific technologies: colloidal micro-Newton thrusters (CMNT) to provide low-noise control capability of the spacecraft, and drag-free control flight. This validation is performed using highly sensitive drag-free sensors, which are provided by the LISA Technology Package of the European Space Agency. The Disturbance Reduction System is required to maintain the spacecrafts position with respect to a free-floating test mass to better than 10nmHz, along its sensitive axis (axis in optical metrology). It also has a goal of limiting the residual accelerations of any of the two test masses to below 30 (1 + [f3 mHz]) fmsHz, over the frequency range of 1 to 30 mHz.This paper briefly describes the design and the expected on-orbit performance of the control system for the two modes wherein the drag-free performance requirements are verified. The on-orbit performance of these modes are then compared to the requirements, as well as to the expected performance, and discussed.

Computers and School Nurses in a Financially Stressed School System: The Case of St. Louis

ERIC Educational Resources Information Center

Cummings, Scott

2013-01-01

This article describes the incorporation of computer technology into the professional lives of school nurses. St. Louis, Missouri, a major urban school system, is the site of the study. The research describes several major impacts computer technology has on the professional responsibilities of school nurses. Computer technology not only affects…

Facility Planning for 21st Century. Technology, Industry, and Education.

ERIC Educational Resources Information Center

Hill, Franklin

When the Orange County School Board (Orlando, Florida) decided to build a new high school, they recognized Central Florida's high technology emphasis as a special challenge. The new facility needed to meet present instructional demands while being flexible enough to incorporate 21st century technologies. The final result is a new $30 million high…

Teachers' Perceived Barriers to Technology Integration as Prescribed by 21st Century Learning Skills

ERIC Educational Resources Information Center

Young, Diane Killough

2012-01-01

Technology is a learning and teaching tool that enhances students' communication, innovation, and critical thinking skills, also known as 21st century learning goals. Successfully using technology in the classroom to promote these learning goals, however, has presented some challenges for teachers. While research has identified a variety of…

In Search of Validity Evidence in Support of the Interpretation and Use of Assessments of Complex Constructs: Discussion of Research on Assessing 21st Century Skills

ERIC Educational Resources Information Center

Ercikan, Kadriye; Oliveri, María Elena

2016-01-01

Assessing complex constructs such as those discussed under the umbrella of 21st century constructs highlights the need for a principled assessment design and validation approach. In our discussion, we made a case for three considerations: (a) taking construct complexity into account across various stages of assessment development such as the…

De-MetaST-BLAST: A Tool for the Validation of Degenerate Primer Sets and Data Mining of Publicly Available Metagenomes

PubMed Central

Gulvik, Christopher A.; Effler, T. Chad; Wilhelm, Steven W.; Buchan, Alison

2012-01-01

Development and use of primer sets to amplify nucleic acid sequences of interest is fundamental to studies spanning many life science disciplines. As such, the validation of primer sets is essential. Several computer programs have been created to aid in the initial selection of primer sequences that may or may not require multiple nucleotide combinations (i.e., degeneracies). Conversely, validation of primer specificity has remained largely unchanged for several decades, and there are currently few available programs that allows for an evaluation of primers containing degenerate nucleotide bases. To alleviate this gap, we developed the program De-MetaST that performs an in silico amplification using user defined nucleotide sequence dataset(s) and primer sequences that may contain degenerate bases. The program returns an output file that contains the in silico amplicons. When De-MetaST is paired with NCBI’s BLAST (De-MetaST-BLAST), the program also returns the top 10 nr NCBI database hits for each recovered in silico amplicon. While the original motivation for development of this search tool was degenerate primer validation using the wealth of nucleotide sequences available in environmental metagenome and metatranscriptome databases, this search tool has potential utility in many data mining applications. PMID:23189198

Application of implicit attitude measures to the blood donation context.

PubMed

Warfel, Regina M; France, Christopher R; France, Janis L

2012-02-01

Past blood donation research has relied on explicit (self-report) measures to understand blood donation motivations, but has not yet considered the inherent implicit or automatic processing involved in decision-making. This study addresses this limitation by introducing and validating two novel implicit measures of blood donation attitudes. Healthy young adults (n = 253) performed both image and word versions of a Single Target Implicit Association Test (ST-IAT) and then completed self-report measures of blood donation attitudes, blood and needle fears, social desirability, and donation intention. These results affirmed the validity of the blood donation ST-IATs in at least three ways. First, as expected, nondonors demonstrated more negative implicit donation attitudes than donors. Second, the implicit measures were significantly related in expected directions with explicit measures of donation attitudes as well as blood and needle fears. Finally, implicit donation attitudes were significantly related to donation intention, and the Image ST-IAT (but not the Word ST-IAT) significantly enhanced prediction of donation intention over and above needle fears and marginally enhanced prediction over and above blood fears. Image and word versions of the blood donation ST-IAT offer a valid method of assessing underlying automatic attitudes toward blood donation. © 2012 American Association of Blood Banks.

78 FR 22529 - Notice of Intent To Grant Partially Exclusive Patent License; Max-Viz, Inc.

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-16

... Technology Applications, Space and Naval Warfare Systems Center Pacific, Code 72120, 53560 Hull St, Bldg A33... Technology Applications, Space and Naval Warfare Systems Center Pacific, Code 72120, 53560 Hull St, Bldg A33...

National parks : transportation alternatives and advanced technology for the 21st century : conference proceedings

DOT National Transportation Integrated Search

1999-06-03

This overview provides a description of the proceedings of a conference entitled, "National Parks: Transportation Alternatives and Advanced Technology for the 21st Century," sponsored by the Western Transportation Institute at Montana State Universit...

Species distribution, virulence factors, and antimicrobial resistance of Acinetobacter spp. isolates from dogs and cats: a preliminary study.

PubMed

Kimura, Yui; Harada, Kazuki; Shimizu, Takae; Sato, Tomomi; Kajino, Akari; Usui, Masaru; Tamura, Yutaka; Tsuyuki, Yuzo; Miyamoto, Tadashi; Ohki, Asami; Watarai, Masahisa

2018-05-12

We investigated the prevalence of virulence factors and antimicrobial resistance among 67 Acinetobacter spp. isolates, consisting of 21 Acinetobacter baumannii and 46 non-baumannii Acinetobacter from companion animals. The PCR analysis showed that the most prevalent virulence gene was afa/draBC (29.9%), followed by papC (22.4%) and cvaC (20.9%). Antimicrobial susceptibility testing revealed that resistance to gentamicin (14.9%) and ciprofloxacin (11.9%) was relatively prevalent. Five gentamicin- and/or ciprofloxacin-resistant A. baumannii strains were assigned to ST25, ST149, ST164, ST203, and ST1198. All ciprofloxacin-resistant isolates harbored point mutations in gyrA and/or parC. This is the first preliminary monitoring of animal-origin Acinetobacter spp. in Japan. © 2018 The Societies and John Wiley & Sons Australia, Ltd.

Connections and Collaborations: Technology and People for the 1990s. Proceedings of the Association for the Development of Computer-Based Instructional Systems International Conference (33rd, St. Louis, Missouri, November 11-14, 1991).

ERIC Educational Resources Information Center

Dalton, David W., Ed.; And Others

This collection of conference presentations contains 48 papers and 122 abstracts (for which there are no formal papers). The papers and abstracts are presented in two separate sections, but both are categorized by special interest groups: (1) Academic Computing (SIGAC, 1 paper, 9 abstracts); (2) Computer-Based Training (SIGCBT, 8 papers, 12…

Precision Positioning and Inertial Guidance Sensors. Technology and Operational Aspects

DTIC Science & Technology

1981-03-01

Ueberlingen, GE EVALUATION D’UN SYSTEME EUROPEEN DE NAVIGATION HYBRIDE A - - GYROLASER POUR HELICOPTERE: "SEXTAN" by D Regnault, Centre d’Essais en Vol de...NAVIGATION SYSTEM AND STANDARD STATE ELEMENT DEVIATIONMEASUREMENT SOURCES( Dead-reckoning with position fxP fy 5000 En ]TAS, heading and wind scale...Reproduction Ltd ilarford House. 7-9 Charlotte St. London. WIP JIHD [i Ii THEME A new class of precision positioning systems , including GPS (Global

Closing of water circuits - a global benchmark on sustainable water management

NASA Astrophysics Data System (ADS)

Fröhlich, Siegmund

2017-11-01

Access to clean water resources has always been a crucial factor in the history of mankind. Now, in the 21st century, water, as an increasingly scarce resource, will take a strategic role for the future development of global populations. As the former UN Secretary General Dr. Dr. Boutrous Boutrous Ghali predicts: "The wars of the 21st century will be fought not over oil, they will be fought over water." [1]. In nine global examples will be demonstrated the different ways of dealing with water resources. That are: Mexico City, Egypt, Libya, DOW Terneuzen, Los Angeles, Israel, China and Singapore and also global trends, such as, scarcity & rural exodus and salinization of soil. Thereby, he explains the different kinds of water management to be observed. The most relevant prognosis of the WHO is, that to the end of 21st century Africa's population will grow over proportionally from 1 billion now up to nearly 4 billion [9]. That is why all efforts need to be concentrated on helping Africa create a sustainable economic development. The first and by far most important strategic step is to assure access to clean water resources in the rural and mostly arid regions of the continent. The lecturer shows several technological proposals on how to overcame problems like: water scarcity, rural exodus, salinization of soil and others. Such technologies could be successfully implemented in sustainable development programs in African countries.

St. Lawrence Seaway : potential opportunities for the application of information and communication technologies : discussion paper

DOT National Transportation Integrated Search

2017-04-01

This report is the second in a series of two reports focused on identifying opportunities for application of Intelligent Transportation System (ITS)technology or equivalent to address challenges and/or opportunities in the St. Lawrence Seaway...

77 FR 34030 - Notice of Intent To Grant Partially Exclusive Patent License; Lumedyne Technologies, Inc.

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-08

... and Technology Applications Space and Naval Warfare Systems Center Pacific, Code 72120, 53560 Hull St... Hull St, Bldg A33 Room 2531, San Diego, CA 92152-5001, telephone 619-553-5118, E-Mail: [email protected

78 FR 32380 - Notice of Intent To Grant Partially Exclusive Patent License; Lumedyne Technologies, Inc.

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-30

... Technology Applications, Space and Naval Warfare Systems Center Pacific, Code 72120, 53560 Hull St., Bldg... Hull St., Bldg. A33 Room 2531, San Diego, CA 92152-5001, telephone 619-553-5118, E-Mail: [email protected

How Deeper Learning and 21st Century Skills Influenced One Suburban District's Transition to 1:1 Student Technology

ERIC Educational Resources Information Center

Dillon, Paula A.

2017-01-01

The purpose of this study was to examine administrator, student, and teacher perceptions of organizational structures, systems, and supports implemented to aid technology integration, and the potential for that technology integration to achieve 21st century skill acquisition and deeper learning in a 1:1 environment. The Diffusion of Innovation…

Transforming Science Teaching Environment for the 21st Century Primary School Pupils

ERIC Educational Resources Information Center

Sheikh Abdullah, Siti Hendon

2016-01-01

The transformation of technology in the 21st century has produced children who are technology savvy and exposed to the internet and social networking at a very young age. These children are already in our school system. Thus teachers too need to use technology and transform the learning environment to meet the requirements of these children. This…

Promoting Children's Learning through Technology Literacy: Challenges to School Librarians in the 21st Century

ERIC Educational Resources Information Center

Ejikeme, Anthonia N.; Okpala, Helen N.

2017-01-01

In today's world of technological revolution, children need to be encouraged to be ready to acquire lifelong knowledge and skills in the 21st century. This paper presents an overview of the application of technologies in children's learning environment which apparently will give them the opportunity of making use of their thinking skills in order…

Cross-cultural validation of the St. Louis Inventory of Community Living Skills for Chinese patients with schizophrenia in Hong Kong.

PubMed

Au, Raymond Wing Cheong; Tam, Peter Wai Chung; Tam, Gladys Wai Chi; Ungvari, Gabor Sander

2005-01-01

The study validated a culturally sensitive community living skills rating scale for Chinese patients by adapting the St. Louis Inventory of Community Living Skills (SLICLS). The Chinese version (SLICLS-C) was produced by forward and backward translation. An expert panel evaluated its content validity. Its internal consistency, inter-rater reliability, construct and concurrent validity were tested on 80 DSM-IV schizophrenia inpatients in a long-term facility. For predictive validity, the above sample was extended to ensure at least 20 subjects discharged to each of three levels of community care were included in the study sample. The SLICLS-C was psychometrically sound and could be used for predicting level of community care, program evaluation and measuring outcome.

A perspective on space exploration technology catalysis: A rationale for initiating 21st Century expansion of human civilization into outer space

NASA Technical Reports Server (NTRS)

Horsham, Gary A. P.

1988-01-01

The rationale for human exploration of space is examined. Observations of the technocatalytic potential are presented. Transferability to the terrestrial environment of 21st Century Earth is discussed. The many threats to future survival of this planet's sensitive ecosystem are also discussed in relation to the technoecological harmony that might be achievable due to the extreme demands that are naturally imposed on the development of (civilian/human) space technology. The human attempt to inhabit the inner solar system (the Moon, Mars, etc.) is proposed as the ultimate and most appropriate technology driver for the myriad of socioeconomic, ecological, and technological needs that will accompany 21st Century Earth societies.

St8sia2 deficiency plus juvenile cannabis exposure in mice synergistically affect higher cognition in adulthood.

PubMed

Tantra, Martesa; Kröcher, Tim; Papiol, Sergi; Winkler, Daniela; Röckle, Iris; Jatho, Jasmin; Burkhardt, Hannelore; Ronnenberg, Anja; Gerardy-Schahn, Rita; Ehrenreich, Hannelore; Hildebrandt, Herbert

2014-12-15

The neural cell adhesion molecule (NCAM) and its functionally linked polysialyltransferases, ST8SIA2 and ST8SIA4, are crucial for synaptic plasticity. Variations in encoding genes have been associated with mental illness. Since cannabinoids can alter NCAM polysialylation, we hypothesized that delta-9-tetrahydrocannabinol (Δ9-THC) might act as environmental 'second hit' regarding cognition of St8sia2(-/-) mice. These mice show per se minor behavioral abnormalities, consisting of reduced anxiety and mild cognitive deficits. Chronic Δ9-THC treatment of juvenile male wildtype mice (St8sia2(+/+)) (7mg/kg every other day over 3 weeks) did not appreciably affect cognition. St8sia2(-/-) mice, however, displayed a synergistic negative consequence of Δ9-THC on learning/memory, accompanied by polysialic acid-free NCAM-180 reduction in hippocampus and polysialic acid increase in dentate outer molecular layer. These synergistic effects became obvious only months after the last Δ9-THC. We conclude that juvenile cannabis exposure may cause delayed but lasting damage on cognition in subjects genetically predisposed to altered NCAM polysialylation. Copyright © 2014 Elsevier B.V. All rights reserved.

Impact of newer self-monitoring technology and brief phone-based intervention on weight loss: A randomized pilot study.

PubMed

Ross, Kathryn M; Wing, Rena R

2016-08-01

Despite the proliferation of newer self-monitoring technology (e.g., activity monitors and smartphone apps), their impact on weight loss outside of structured in-person behavioral intervention is unknown. A randomized, controlled pilot study was conducted to examine efficacy of self-monitoring technology, with and without phone-based intervention, on 6-month weight loss in adults with overweight and obesity. Eighty participants were randomized to receive standard self-monitoring tools (ST, n = 26), technology-based self-monitoring tools (TECH, n = 27), or technology-based tools combined with phone-based intervention (TECH + PHONE, n = 27). All participants attended one introductory weight loss session and completed assessments at baseline, 3 months, and 6 months. Weight loss from baseline to 6 months differed significantly between groups P = 0.042; there was a trend for TECH + PHONE (-6.4 ± 1.2 kg) to lose more weight than ST (-1.3 ± 1.2 kg); weight loss in TECH (-4.1 ± 1.4 kg) was between ST and TECH + PHONE. Fewer ST (15%) achieved ≥5% weight losses compared with TECH and TECH + PHONE (44%), P = 0.039. Adherence to self-monitoring caloric intake was higher in TECH + PHONE than TECH or ST, Ps < 0.05. These results suggest use of newer self-monitoring technology plus brief phone-based intervention improves adherence and weight loss compared with traditional self-monitoring tools. Further research should determine cost-effectiveness of adding phone-based intervention when providing self-monitoring technology. © 2016 The Obesity Society.

Impact of newer self-monitoring technology and brief phone-based intervention on weight loss: a randomized pilot study

PubMed Central

Ross, Kathryn M.; Wing, Rena R.

2016-01-01

Objective Despite the proliferation of newer self-monitoring technology (e.g., activity monitors and smartphone apps), their impact on weight loss outside of structured in-person behavioral intervention is unknown. Methods A randomized, controlled pilot study was conducted to examine efficacy of self-monitoring technology, with and without phone-based intervention, on 6-month weight loss in adults with overweight and obesity. Eighty participants were randomized to receive standard self-monitoring tools (ST, n=26), technology-based self-monitoring tools (TECH, n=27), or technology-based tools combined with phone-based intervention (TECH+PHONE, n=27). All participants attended one introductory weight loss session and completed assessments at baseline, 3 months, and 6 months. Results Weight loss from baseline to 6 months differed significantly between groups p=.042; there was a trend for TECH+PHONE (−6.4±1.2kg) to lose more weight than ST (−1.3±1.2kg); weight loss in TECH (−4.1±1.4kg) was between ST and TECH+PHONE. Fewer ST (15%) achieved ≥5% weight losses compared to TECH and TECH+PHONE (44%), p=.039. Adherence to self-monitoring caloric intake was higher in TECH+PHONE than TECH or ST, ps<.05. Conclusion These results suggest use of newer self-monitoring technology plus brief phone-based intervention improves adherence and weight loss compared to traditional self-monitoring tools. Further research should determine cost-effectiveness of adding phone-based intervention when providing self-monitoring technology. PMID:27367614

University/Industry Alliances. Hearing before the Subcommittee on Science, Research and Technology of the Committee on Science, Space, and Technology, U.S. House of Representatives. One Hundredth Congress, Second Session, [St. Louis, Missouri] February 8, 1988.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. House Committee on Science, Space and Technology.

This document contains the transcript and prepared statements submitted for a Congressional hearing at the University of Missouri-St. Louis. Introductory statements by the committee chairman, Representative Doug Walgren, Representative Jack Buechner of Missouri, and Dr. Marguerite R. Barnett, Chancellor of the University of Missouri (St. Louis),…

Science, technology, engineering, mathematics (STEM) as mathematics learning approach in 21st century

NASA Astrophysics Data System (ADS)

Milaturrahmah, Naila; Mardiyana, Pramudya, Ikrar

2017-08-01

This 21st century demands competent human resources in science, technology, engineering design and mathematics so that education is expected to integrate the four disciplines. This paper aims to describe the importance of STEM as mathematics learning approach in Indonesia in the 21st century. This paper uses a descriptive analysis research method, and the method reveals that STEM education growing in developed countries today can be a framework for innovation mathematics in Indonesia in the 21st century. STEM education integrate understanding of science, math skills, and the available technology with the ability to perform engineering design process. Implementation of mathematics learning with STEM approach makes graduates trained in using of mathematics knowledge that they have to create innovative products that are able to solve the problems that exist in society.

Secondary Traumatization in Psychiatric Mental Health Nurses: Validation of Five Key Concepts.

PubMed

Hubbard, Grace B; Beeber, Linda; Eves, Erin

2017-04-01

The purpose of this study was to validate five concepts central to secondary traumatization (ST) using narratives of psychiatric mental health advanced practice nurses. The study was designed as a directed content analysis of narrative notes (N-30). Consistency was found between narrative notes and the concepts. This study revealed that exposure and vulnerability precede empathic engagement, reaction, and alteration/transformation. The bidirectional outcome of alteration/transformation suggested that conditions leading to ST could have a positive outcome. Failure to recognize symptoms of ST and provide reflective supervision may compromise the nurse's ability to maintain a work-life balance and provide quality patient care. © 2015 Wiley Periodicals, Inc.

Measurement Instrument for Scientific Teaching (MIST): A Tool to Measure the Frequencies of Research-Based Teaching Practices in Undergraduate Science Courses

PubMed Central

Durham, Mary F.; Knight, Jennifer K.; Couch, Brian A.

2017-01-01

The Scientific Teaching (ST) pedagogical framework provides various approaches for science instructors to teach in a way that more closely emulates how science is practiced by actively and inclusively engaging students in their own learning and by making instructional decisions based on student performance data. Fully understanding the impact of ST requires having mechanisms to quantify its implementation. While many useful instruments exist to document teaching practices, these instruments only partially align with the range of practices specified by ST, as described in a recently published taxonomy. Here, we describe the development, validation, and implementation of the Measurement Instrument for Scientific Teaching (MIST), a survey derived from the ST taxonomy and designed to gauge the frequencies of ST practices in undergraduate science courses. MIST showed acceptable validity and reliability based on results from 7767 students in 87 courses at nine institutions. We used factor analyses to identify eight subcategories of ST practices and used these categories to develop a short version of the instrument amenable to joint administration with other research instruments. We further discuss how MIST can be used by instructors, departments, researchers, and professional development programs to quantify and track changes in ST practices. PMID:29196428

Elementary School Teachers' Beliefs about the Role of Technology in 21st-Century Teaching and Learning

ERIC Educational Resources Information Center

O'Neal, LaToya J.; Gibson, Philip; Cotten, Shelia R.

2017-01-01

Technological advancements have led to changes in the expectations placed on K-12 teachers. Teachers are now expected to better equip students with 21st-century skills, making it important to understand teachers' beliefs about the role of technology in teaching and learning and the skills their students need to be successful. Using a qualitative…

Measurements versus Predictions for a Hybrid (Hydrostatic Plus Hydrodynamic) Thrust Bearing for a Range of Orifice Diameters

DTIC Science & Technology

2010-05-01

Type of Lubrication for a Tilting Pad Thrust Bearing ,” ASME Journal of Lubrication Technology, 96 Ser F (1), pp. 22-27. [9] Gregory, R.S., 1974...1986, “Measurements of Maximum Temperature in Tilting - Pad Thrust Bearings ,” Technical Preprints - Presented at the ASLE 41st Annual Meeting. (ASLE...Safar [7] provides a modified Reynolds number analysis on hydrostatic thrust bearing performance parameters including the effects of tilt . Finally, San

Hematologic and Selected Hepatic Changes Produced by Substituted p-Bensoquinones in the Rat.

DTIC Science & Technology

1980-07-01

DIVISION OF NUTRITION TECHNOLOGY *DIVISION OF CUTANEOUS HAZARDS I LEECE D IBAI7 TA EMENl AU I __ b rouleISO, Ca. JULYV 1980 CD, LA. 9=3TIRMAN ARMY...jaundice, anemia, hemoglobinuria, and cachexia (8). In previous studies, we found that benzoquinone tox- icity in rats resulted in respiratory depression...randomly housed in stainless steel wire-bottomed cages, one to a cage, and fed a stock diet (Rodent Laboratory Chow #5001, Ralston Purina Co., St. Louis

Future Deployment and Distribution Assessment (FDDA)

DTIC Science & Technology

2011-01-26

speed capability gaps in top 10 • “Rogue” MVM gap 0 10 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 ranked highly • All Seabasing...gaps ranked highly by USA Capability Gap Priority Number Automated Technologies Austere Access / Speed Mounted Vertical Maneuver ( MVM ) Themes and DLA...austere access, MVM , and Seabasing n ras ruc ure Predictive Logistics UNCLASSIFIED Collect and Map S&T Initiatives Developed JDDE Collected and

Changing the Introduction to Fighter Fundamentals Course for 21st Century F-15C Pilots

DTIC Science & Technology

2016-01-01

IFF model based on the success the USAF has enjoyed in establishing Air Superiority. There is no argument the United States has enjoyed the blanket ...dangerous place and so is the air superiority domain. Our country has gone to great lengths procuring new advanced weapons such as the F-22A and...F-35A, meanwhile updating older aircraft with advanced technology to ensure air dominance.9 So have her near peer adversaries, such as Russia and

Development of Medical Technology for Contingency Response to Marrow Toxic Agents

DTIC Science & Technology

2013-10-30

NUMBER N/A 5b. GRANT NUMBER N00014-12-1-0142 5c. PROGRAM ELEMENT NUMBER N/A 6. AUTHOR( S ) Spellman, Stephen 5d. PROJECT NUMBER N/A 5e. TASK...NUMBER Project 1, 2, 3, 4 5f. WORK UNIT NUMBER N/A 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) National Marrow Donor Program 3001 Broadway...St., N.E., Ste. 500 Minneapolis, MN 55413 8. PERFORMING ORGANIZATION REPORT NUMBER N/A 9. SPONSORING/MONITORING AGENCY NAME( S ) AND ADDRESS(ES

Clinical Predictive Models for Chemotherapy-Induced Febrile Neutropenia in Breast Cancer Patients: A Validation Study

PubMed Central

Zhu, Liling; Su, Fengxi; Jia, Weijuan; Deng, Xiaogeng

2014-01-01

Background Predictive models for febrile neutropenia (FN) would be informative for physicians in clinical decision making. This study aims to validate a predictive model (Jenkin’s model) that comprises pretreatment hematological parameters in early-stage breast cancer patients. Patients and Methods A total of 428 breast cancer patients who received neoadjuvant/adjuvant chemotherapy without any prophylactic use of colony-stimulating factor were included. Pretreatment absolute neutrophil counts (ANC) and absolute lymphocyte counts (ALC) were used by the Jenkin’s model to assess the risk of FN. In addition, we modified the threshold of Jenkin’s model and generated Model-A and B. We also developed Model-C by incorporating the absolute monocyte count (AMC) as a predictor into Model-A. The rates of FN in the 1st chemotherapy cycle were calculated. A valid model should be able to significantly identify high-risk subgroup of patients with FN rate >20%. Results Jenkin’s model (Predicted as high-risk when ANC≦3.1*10∧9/L;ALC≦1.5*10∧9/L) did not identify any subgroups with significantly high risk (>20%) of FN in our population, even if we used different thresholds in Model-A(ANC≦4.4*10∧9/L;ALC≦2.1*10∧9/L) or B(ANC≦3.8*10∧9/L;ALC≦1.8*10∧9/L). However, with AMC added as an additional predictor, Model-C(ANC≦4.4*10∧9/L;ALC≦2.1*10∧9/L; AMC≦0.28*10∧9/L) identified a subgroup of patients with a significantly high risk of FN (23.1%). Conclusions In our population, Jenkin’s model, cannot accurately identify patients with a significant risk of FN. The threshold should be changed and the AMC should be incorporated as a predictor, to have excellent predictive ability. PMID:24945817

27 CFR 9.51 - Isle St. George.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Isle St. George. 9.51 Section 9.51 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.51 Isle...

27 CFR 9.51 - Isle St. George.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Isle St. George. 9.51 Section 9.51 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.51 Isle...

27 CFR 9.51 - Isle St. George.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Isle St. George. 9.51 Section 9.51 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.51 Isle...

Identification of QTN and candidate genes for Salinity Tolerance at the Germination and Seedling Stages in Rice by Genome-Wide Association Analyses.

PubMed

Naveed, Shahzad Amir; Zhang, Fan; Zhang, Jian; Zheng, Tian-Qing; Meng, Li-Jun; Pang, Yun-Long; Xu, Jian-Long; Li, Zhi-Kang

2018-04-25

To facilitate developing rice varieties tolerant to salt stress, a panel of 208 rice mini-core accessions collected from 25 countries were evaluated for 13 traits associated with salt tolerance (ST) at the germination and seedling stages. The rice panel showed tremendous variation for all measured ST traits and eight accessions showing high levels of ST at either and/or both the germination and seedling stages. Using 395,553 SNP markers covering ~372 Mb of the rice genome and multi-locus mixed linear models, 20 QTN associated with 11 ST traits were identified by GWAS, including 6 QTN affecting ST at the germination stage and 14 QTN for ST at the seedling stage. The integration of bioinformatic with haplotype analyses for the ST QTN lets us identify 22 candidate genes for nine important ST QTN (qGR3, qSNK1, qSNK12, qSNC1, qSNC6, qRNK2, qSDW9a, qSST5 and qSST9). These candidate genes included three known ST genes (SKC1, OsTZF1 and OsEATB) for QTN qSNK1 qSST5 and qSST9. Candidate genes showed significant phenotypic differences in ST traits were detected between or among 2-4 major haplotypes. Thus, our results provided useful materials and genetic information for improving rice ST in future breeding and for molecular dissection of ST in rice.

Science and Technology Data Book. 1986.

ERIC Educational Resources Information Center

National Science Foundation, Washington, DC. Div. of Science Resources Studies.

Science and technology (S&T) data are presented in 36 charts, graphs, or tables. These data are organized into three major categories, namely, research and development (R&D) funding, human resources, and international S&T indicators. R&D funding is subdivided into national, federal, industry, and academic categories, with data…

Uropathogenic Escherichia coli ST131 in urinary tract infections in children.

PubMed

Yun, Ki Wook; Lee, Mi-Kyung; Kim, Wonyong; Lim, In Seok

2017-07-01

Escherichia coli sequence type (ST) 131, a multidrug-resistant clone causing extraintestinal infections, has rapidly become prevalent worldwide. However, the epidemiological and clinical features of pediatric infections are poorly understood. We aimed to explore the characteristics of ST131 Escherichia coli isolated from Korean children with urinary tract infections. We examined 114 uropathogenic E. coli (UPEC) isolates from children hospitalized at Chung-Ang University Hospital between 2011 and 2014. Bacterial strains were classified into STs by partial sequencing of seven housekeeping genes ( adk , fumC , gyrB , icd , mdh , purA , and recA ). Clinical characteristics and antimicrobial susceptibility were compared between ST131 and non-ST131 UPEC isolates. Sixteen UPEC isolates (14.0%) were extended-spectrum β-lactamase (ESBL)-producers; 50.0% of ESBL-producers were ST131 isolates. Of all the isolates tested, 13.2% (15 of 114) were classified as ST131. There were no statistically significant associations between ST131 and age, sex, or clinical characteristics, including fever, white blood cell counts in urine and serum, C-reactive protein, radiologic abnormalities, and clinical outcome. However, ST131 isolates showed significantly lower rates of susceptibility to cefazolin (26.7%), cefotaxime (40.0%), cefepime (40.0%), and ciprofloxacin (53.3%) than non-ST131 isolates (65.7%, 91.9%, 92.9%, and 87.9%, respectively; P <0.001 for all). ESBL was more frequently produced in ST131 (53.3%) than in non-ST131 (8.1%) isolates ( P <0.01). ST131 E. coli isolates were prevalent uropathogens in children at a single medical center in Korea between 2011 and 2014. Although ST131 isolates showed higher rates of antimicrobial resistance, clinical presentation and outcomes of patients were similar to those of patients infected with non-ST131 isolates.

Validation of a Measure of Normative Beliefs About Smokeless Tobacco Use

PubMed Central

O’Connor, Richard J.; Bansal-Travers, Maansi; Cummings, K. Michael; Rees, Vaughan W.; Hatsukami, Dorothy K.

2016-01-01

Abstract Introduction: Validated methods to evaluate consumer responses to modified risk tobacco products (MRTPs) are needed. Guided by existing literature that demonstrates a relationship between normative beliefs and future intentions to use tobacco the current research sought to (1) develop a measure of normative beliefs about smokeless tobacco (ST) and establish the underlying factor structure, (2) evaluate the structure with confirmatory factor analysis utilizing an independent sample of youth, and (3) establish the measure’s concurrent validity. Methods: Respondents (smokers and nonsmokers aged 15–65; N = 2991) completed a web-based survey that included demographic characteristics, tobacco use history and dependence, and a measure of attitudes about ST adapted from the Normative Beliefs about Smoking scale. A second sample of youth (aged 14–17; N = 305) completed a similar questionnaire. Results: Exploratory factor analysis produced the anticipated three-factor solution and accounted for nearly three-quarters of the variance in the data reflecting (1) perceived prevalence of ST use, (2) popularity of ST among successful/elite, and (3) approval of ST use by parents/peers. Confirmatory factor analysis with data from the youth sample demonstrated good model fit. Logistic regression demonstrated that the scales effectively discriminate between ST users and nonusers and are associated with interest in trying snus. Conclusions: Assessment of MRTPs for regulatory purposes, which allows messages of reduced risk, should include measurement of social norms. Furthermore, surveillance efforts that track use of new MRTPs should include measures of social norms to determine how norms change with prevalence of use. PMID:26187390

Current status of robotic simulators in acquisition of robotic surgical skills.

PubMed

Kumar, Anup; Smith, Roger; Patel, Vipul R

2015-03-01

This article provides an overview of the current status of simulator systems in robotic surgery training curriculum, focusing on available simulators for training, their comparison, new technologies introduced in simulation focusing on concepts of training along with existing challenges and future perspectives of simulator training in robotic surgery. The different virtual reality simulators available in the market like dVSS, dVT, RoSS, ProMIS and SEP have shown face, content and construct validity in robotic skills training for novices outside the operating room. Recently, augmented reality simulators like HoST, Maestro AR and RobotiX Mentor have been introduced in robotic training providing a more realistic operating environment, emphasizing more on procedure-specific robotic training . Further, the Xperience Team Trainer, which provides training to console surgeon and bed-side assistant simultaneously, has been recently introduced to emphasize the importance of teamwork and proper coordination. Simulator training holds an important place in current robotic training curriculum of future robotic surgeons. There is a need for more procedure-specific augmented reality simulator training, utilizing advancements in computing and graphical capabilities for new innovations in simulator technology. Further studies are required to establish its cost-benefit ratio along with concurrent and predictive validity.

Validation of Clinical Testing for Warfarin Sensitivity

PubMed Central

Langley, Michael R.; Booker, Jessica K.; Evans, James P.; McLeod, Howard L.; Weck, Karen E.

2009-01-01

Responses to warfarin (Coumadin) anticoagulation therapy are affected by genetic variability in both the CYP2C9 and VKORC1 genes. Validation of pharmacogenetic testing for warfarin responses includes demonstration of analytical validity of testing platforms and of the clinical validity of testing. We compared four platforms for determining the relevant single nucleotide polymorphisms (SNPs) in both CYP2C9 and VKORC1 that are associated with warfarin sensitivity (Third Wave Invader Plus, ParagonDx/Cepheid Smart Cycler, Idaho Technology LightCycler, and AutoGenomics Infiniti). Each method was examined for accuracy, cost, and turnaround time. All genotyping methods demonstrated greater than 95% accuracy for identifying the relevant SNPs (CYP2C9 *2 and *3; VKORC1 −1639 or 1173). The ParagonDx and Idaho Technology assays had the shortest turnaround and hands-on times. The Third Wave assay was readily scalable to higher test volumes but had the longest hands-on time. The AutoGenomics assay interrogated the largest number of SNPs but had the longest turnaround time. Four published warfarin-dosing algorithms (Washington University, UCSF, Louisville, and Newcastle) were compared for accuracy for predicting warfarin dose in a retrospective analysis of a local patient population on long-term, stable warfarin therapy. The predicted doses from both the Washington University and UCSF algorithms demonstrated the best correlation with actual warfarin doses. PMID:19324988

JPRS Report, Science & Technology, Japan, 1989 S&T Agency Annual 33

DTIC Science & Technology

1991-01-10

enter- prises are being put into operation. 46 JPRS-JST-91-001 10 January 1991 Shizuoka Prefecture, the Toyama Prefecture and Ishikawa Prefecture...Technology Agency, Ishikawa Prefecture "Topics in 21st-Century-Oriented Science and Technology Promotion in Ishikawa Prefecture" 200 people (From...Shiga Atomic Energy Ooi3 Ikata3 Genkai Atomic Energy 3 Shizuoka Prefecture, Oryu District, Hamaoka Town Ishikawa Prefecture, Hanesa District

Engineering and Technology Education for the 21st Century. A Report from the Regional Colloquium on Engineering and Technology Education for the 21st Century (Nakhon Ratchasima, Thailand, February 11-14, 1997).

ERIC Educational Resources Information Center

Kettle, Kevin C., Ed.

This colloquium was held with the purposes of promoting cooperation and collaboration among engineering education institutions in the Mekong subregion and establishing the linkage with engineering institutions in France; to promote university-industry collaboration in the field of engineering and technology education; to establish a network of…

How Do Learners in Different Cultures Related to Science and Technology? Results and Perspectives from the Project Rose (The Relevance of Science Education)

ERIC Educational Resources Information Center

Sjøberg, Svein; Schreiner, Camilla

2005-01-01

The position of science and technology (S&T) in a society changes through time and from one society to another. In developing countries, many young people would like to opt for a career in S&T, while many rich, highly-developed countries notice declining recruitment of students to science and technology studies. In this article, the…

Risk assessment methodology applied to counter IED research & development portfolio prioritization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shevitz, Daniel W; O' Brien, David A; Zerkle, David K

2009-01-01

In an effort to protect the United States from the ever increasing threat of domestic terrorism, the Department of Homeland Security, Science and Technology Directorate (DHS S&T), has significantly increased research activities to counter the terrorist use of explosives. More over, DHS S&T has established a robust Counter-Improvised Explosive Device (C-IED) Program to Deter, Predict, Detect, Defeat, and Mitigate this imminent threat to the Homeland. The DHS S&T portfolio is complicated and changing. In order to provide the ''best answer'' for the available resources, DHS S&T would like some ''risk based'' process for making funding decisions. There is a definitemore » need for a methodology to compare very different types of technologies on a common basis. A methodology was developed that allows users to evaluate a new ''quad chart'' and rank it, compared to all other quad charts across S&T divisions. It couples a logic model with an evidential reasoning model using an Excel spreadsheet containing weights of the subjective merits of different technologies. The methodology produces an Excel spreadsheet containing the aggregate rankings of the different technologies. It uses Extensible Logic Modeling (ELM) for logic models combined with LANL software called INFTree for evidential reasoning.« less

NASA-UVA Light Aerospace Alloy and Structures Technology Program (LA2ST). Research on Materials for the High Speed Civil Transport

NASA Technical Reports Server (NTRS)

Gangloff, Richard P.; Starke, Edgar A., Jr.; Kelly, Robert G.; Scully, John R.; Stoner, Glenn E.; Wert, John A.

1997-01-01

Since 1986, the NASA-Langley Research Center has sponsored the NASA-UVa Light Alloy and Structures Technology (LA2ST) Program at the University of Virginia (UVa). The fundamental objective of the LA2ST program is to conduct interdisciplinary graduate student research on the performance of next generation, light-weight aerospace alloys, composites and thermal gradient structures. The LA2ST program has aimed to product relevant data and basic understanding of material mechanical response, environmental/corrosion behavior, and microstructure; new monolithic and composite alloys; advanced processing methods; measurement and modeling advances; and a pool of educated graduate students for aerospace technologies. The scope of the LA2ST Program is broad. Research areas include: (1) Mechanical and Environmental Degradation Mechanisms in Advanced Light Metals and Composites, (2) Aerospace Materials Science, (3) Mechanics of materials for Aerospace Structures, and (4) Thermal Gradient Structures. A substantial series of semi-annual progress reports issued since 1987 documents the technical objectives, experimental or analytical procedures, and detailed results of graduate student research in these topical areas.

Space power technology into the 21st century

NASA Technical Reports Server (NTRS)

Faymon, K. A.; Fordyce, J. S.

1984-01-01

This paper discusses the space power systems of the early 21st century. The focus is on those capabilities which are anticipated to evolve from today's state-of-the-art and the technology development programs presently in place or planned for the remainder of the century. The power system technologies considered include solar thermal, nuclear, radioisotope, photovoltaic, thermionic, thermoelectric, and dynamic conversion systems such as the Brayton and Stirling cycles. Energy storage technologies considered include nickel hydrogen biopolar batteries, advanced high energy rechargeable batteries, regenerative fuel cells, and advanced primary batteries. The present state-of-the-art of these space power and energy technologies is discussed along with their projections, trends and goals. A speculative future mission model is postulated which includes manned orbiting space stations, manned lunar bases, unmanned earth orbital and interplanetary spacecraft, manned interplanetary missions, military applications, and earth to space and space to space transportation systems. The various space power/energy system technologies anticipated to be operational by the early 21st century are matched to these missions.

Space power technology into the 21st Century

NASA Technical Reports Server (NTRS)

Faymon, K. A.; Fordyce, J. S.

1983-01-01

The space power systems of the early 21st century are discussed. The capabilities which are anticipated to evolve from today's state of the art and the technology development programs presently in place or planned for the remainder of the century are emphasized. The power system technologies considered include: solar thermal, nuclear, radioisotope, photovoltaic, thermionic, thermoelectric, and dynamic conversion systems such as the Brayton and Stirling cycles. Energy storage technologies considered include: nickel hydrogen biopolar batteries, advanced high energy rechargeable batteries, regenerative fuel cells, and advanced primary batteries. The present state of the art of these space power and energy technologies is discussed along with their projections, trends and goals. A speculative future mission model is postulated which includes manned orbiting space stations, manned lunar bases, unmanned Earth orbital and interplanetary spacecraft, manned interplanetary missions, military applications, and Earth to space and space to space transportation systems. The various space power/energy system technologies which are anticipated to be operational by the early 21st century are matched to these missions.

Developing a Data Set and Processing Methodology for Fluid/Structure Interaction Code Validation

DTIC Science & Technology

2007-06-01

50 29. 9-Probe Wake Survey Rake Configurations...structural stability and fatigue in test article components and, in general, in facility support structures and rotating machinery blading . Both T&E... blade analysis and simulations. To ensure the accuracy of the U of CO technology, validation using flight-test data and test data from a wind tunnel

The validity of three fall risk screening tools in an acute geriatric inpatient population.

PubMed

Latt, Mark Dominic; Loh, K Florence; Ge, Ludi; Hepworth, Annie

2016-09-01

We examined the validity of the Ontario Modified STRATIFY (OM) (St Thomas's Risk Assessment Tool in Falling Elderly Inpatients), The Northern Hospital Modified STRATIFY (TNH) and STRATIFY in predicting falls in an acute aged care unit. Data were collected prospectively from 217 people presenting consecutively and falls identified during hospitalisation. Sensitivities of OM (80.0, 95% confidence interval (CI) 58.4 to 91.9%), TNH (85, CI 64.0 to 94.8%) and STRATIFY (80.0, CI 58.4 to 91.0%) were similar. The STRATIFY had higher specificity (61.4, CI 54.5 to 67.9%) than OM (37.1, CI 30.6 to 44.0%) and TNH (51.3, CI 44.3 to 58.2%). Accuracy (percentage of patients correctly classified as 'faller' or 'non-faller') was higher using STRATIFY (63.1, CI 56.5 to 69.3%) and TNH (54.4, CI 47.8 to 61.0%) than with OM (41.0, CI 34.7 to 47.7%, P < 0.0001). Screening tools have limited accuracy in identifying patients at high risk of falls. © 2016 AJA Inc.

Drag-Free Performance of the ST7 Disturbance Reduction System Flight Experiment on the LISA Pathfinder

NASA Technical Reports Server (NTRS)

Maghami, Peiman G.; O'Donnell, James R.; Hsu, Oscar H.; Ziemer, John K.; Dunn, Charles E.

2017-01-01

The Space Technology-7 Disturbance Reduction System (DRS) is an experiment package aboard the European Space Agency (ESA) LISA Pathfinder spacecraft. LISA Pathfinder launched from Kourou, French Guiana on December 3, 2015. The DRS is tasked to validate two specific technologies: colloidal micro-Newton thrusters (CMNT) to provide low-noise control capability of the spacecraft, and drag-free controlflight. This validation is performed using highly sensitive drag-free sensors, which are provided by the LISA Technology Package of the European Space Agency. The Disturbance Reduction System is required to maintain the spacecrafts position with respect to a free-floating test mass to better than 10nm/(square root of Hz), along its sensitive axis (axis in optical metrology). It also has a goal of limiting the residual accelerations of any of the two test masses to below 30 x 10(exp -14) (1 + ([f/3 mHz](exp 2))) m/sq s/(square root of Hz), over the frequency range of 1 to 30 mHz.This paper briefly describes the design and the expected on-orbit performance of the control system for the two modes wherein the drag-free performance requirements are verified. The on-orbit performance of these modes are then compared to the requirements, as well as to the expected performance, and discussed.

Growth differentiation factor 9 reverses activin A suppression of steroidogenic acute regulatory protein expression and progesterone production in human granulosa-lutein cells.

PubMed

Shi, Feng-Tao; Cheung, Anthony P; Klausen, Christian; Huang, He-Feng; Leung, Peter C K

2010-10-01

We have reported that growth differentiation factor 9 (GDF9) can enhance activin A (β(A)β(A))-induced inhibin B (αβ(B)) secretion in human granulosa-lutein (hGL) cells, but its effects on steroidogenic acute regulatory protein (StAR), ovarian steroidogenic enzymes, and progesterone production are unknown. We undertook this study to further evaluate GDF9 in this regard. hGL cells from women undergoing in vitro fertilization treatment were cultured with and without small interfering RNA (siRNA) transfection targeted at inhibin α-subunit or GDF9 before treatment with GDF9, activin A, FSH, or combinations. We compared StAR, P450 side-chain cleavage enzyme, and 3β-hydroxysteroid dehydrogenase expression in hGL cells and progesterone levels in culture media after these treatments. mRNA, protein, and hormone levels were assessed with real-time RT-PCR, immunoblotting, and ELISA, respectively. Data were analyzed by ANOVA followed by Tukey's test. Activin A alone reduced basal and FSH-induced progesterone production by decreasing the expression of StAR protein, which regulates the rate-limiting step in steroidogenesis but not P450 side-chain cleavage enzyme and 3β-hydroxysteroid dehydrogenase. GDF9 attenuated these activin A effects on StAR and progesterone. After transfection of α-subunit siRNA, activin A level increased (P < 0.001), whereas basal and activin A-induced inhibin B levels (with and without GDF9) decreased. Furthermore, the effects of GDF9 in reversing activin A suppression of progesterone production were attenuated (P < 0.001). Transfection of GDF9 siRNA decreased GDF9 as expected and led to lower StAR expression and progesterone secretion than those observed with activin A treatment alone. GDF9 attenuates the suppressive effects of activin A on StAR expression and progesterone production by increasing the expression of inhibin B, which acts as an activin A competitor.

Information Technology Challenges Facing the Strategic Leaders of Homeland Security in the 21st Century

DTIC Science & Technology

2004-05-03

A special thanks to all of these folks (Glenn Starnes, Lee Gutierrez, Bill Rapp, Joel Hillison, Carlos Gomez, Steve Fraunfelter, Janie Hopkins, Dave ...DiClemente, Joe Nunez, John Bonin , and Steve Nerheim). viii INFORMATION TECHNOLOGY CHALLENGES FACING THE STRATEGIC LEADERS OF HOMELAND SECURITY IN THE 21ST

Leveraging 21st Century Learning & Technology to Create Caring Diverse Classroom Cultures

ERIC Educational Resources Information Center

Tarbutton, Tanya

2018-01-01

Creating diverse caring classroom environments, for all students, using innovative technology, is the impetus of this article. Administrators and teachers in many states have worked to integrate 21st Century Learning Outcomes and Local Control and Accountability Plans (LCAP) into daily teaching and learning. These initiatives are designed to…

Computerized Farm of the 21st Century.

ERIC Educational Resources Information Center

McGrann, James M.

Advancement in computer technology comes at a time when agriculture is in transition from a production-oriented to a business-oriented activity and will require new skills and knowledge if farmers are to be prepared for the future. Electronic technology applications on 21st century commercial farms and ranches will include farm decision support…

A Nation of Opportunity: Building America's 21st Century Workforce.

ERIC Educational Resources Information Center

National Alliance of Business, Inc., Washington, DC.

Advances in information technology (IT) are reshaping the U.S. labor market. The demand for workers who can read and understand complex material, think analytically, and use technology efficiently will continue to increase. Congress established the 21st Century Workforce Commission to assess current and future demand for IT workers and the…

Economies of eLearning in the 21st Century

ERIC Educational Resources Information Center

Kasraie, Noah; Kasraie, Esrafill

2010-01-01

The Internet and advancements in the field of information technology have opened up unprecedented opportunities for every citizen to succeed in the 21st Century. Higher education has been utilizing the new technology by offering web-based education. Many universities today offer online classes and even online degrees using eLearning. But how can…

Cardiorespiratory fitness and exercise-induced ST segment depression in assessing the risk of sudden cardiac death in men.

PubMed

Hagnäs, Magnus J; Lakka, Timo A; Kurl, Sudhir; Rauramaa, Rainer; Mäkikallio, Timo H; Savonen, Kai; Laukkanen, Jari A

2017-03-01

The aim of this study was to investigate whether information on both cardiorespiratory fitness (CRF) and exercise-induced ST segment depression improves the prediction of sudden cardiac death (SCD) in men. The study was based on a population sample of 2328 men aged 42-60 years, who were followed up for on average 19 years. CRF was assessed with maximal exercise test using respiratory gas analysis, expressed in metabolic equivalents (METs) and dichotomised at eight METs. Exercise-induced ST segment depression was defined as 1 mm ST segment depression in ECG. Altogether 165 SCDs occurred during the follow-up. Men with low CRF (<8 METs) and exercise-induced ST segment depression had 4.8-fold (95% CI 2.9 to 7.9) higher risk of SCD than men with high CRF and without exercise-induced ST segment depression (p=0.013 for interaction) after adjustment for other cardiovascular risk factors. Men with high CRF and exercise-induced ST segment depression did not have a statistically significantly higher risk of SCD (HR 1.9, 95% CI 0.9 to 3.8) than men with high CRF and without exercise-induced ST segment depression. The combination of low CRF and exercise-induced ST segment depression was associated with a markedly increased risk of SCD in men. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Validation of Geno-Sen's Scrub Typhus Real Time Polymerase Chain Reaction Kit by its Comparison with a Serological ELISA Test

PubMed Central

Anitharaj, Velmurugan; Stephen, Selvaraj; Pradeep, Jothimani; Pooja, Pratheesh; Preethi, Sridharan

2017-01-01

Background: In the recent past, scrub typhus (ST) has been reported from different parts of India, based on Weil-Felix/enzyme-linked immunosorbent assay (ELISA)/indirect immunofluorescence assay (IFA). Molecular tests are applied only by a few researchers. Aims: Evaluation of a new commercial real time polymerase chain reaction (PCR) kit for molecular diagnosis of ST by comparing it with the commonly used IgM ELISA is our aim. Settings and Design: ST has been reported all over India including Puducherry and surrounding Tamil Nadu and identified as endemic for ST. This study was designed to correlate antibody detection by IgM ELISA and Orientia tsutsugamushi DNA in real time PCR. Materials and Methods: ST IgM ELISA (InBios Inc., USA) was carried out for 170 consecutive patients who presented with the symptoms of acute ST during 11 months (November, 2015– September, 2016). All 77 of these patients with IgM ELISA positivity and 49 of 93 IgM ELISA negative patients were subjected to real time PCR (Geno-Sen's ST real time PCR, Himachal Pradesh, India). Statistical Analysis: Statistical analysis for clinical and laboratory results was performed using IBM SPSS Statistics 17 for Windows (SPSS Inc., Chicago, USA). Chi-square test with Yates correction (Fisher's test) was employed for a small number of samples. Results and Conclusion: Among 77 suspected cases of acute ST with IgM ELISA positivity and 49 IgM negative patients, 42 and 7 were positive, respectively, for O. tsutsugamushi 56-kDa type-specific gene in real time PCR kit. Until ST IFA, the gold standard diagnostic test, is properly validated in India, diagnosis of acute ST will depend on both ELISA and quantitative PCR. PMID:28878522

Validation of Geno-Sen's Scrub Typhus Real Time Polymerase Chain Reaction Kit by its Comparison with a Serological ELISA Test.

PubMed

Anitharaj, Velmurugan; Stephen, Selvaraj; Pradeep, Jothimani; Pooja, Pratheesh; Preethi, Sridharan

2017-01-01

In the recent past, scrub typhus (ST) has been reported from different parts of India, based on Weil-Felix/enzyme-linked immunosorbent assay (ELISA)/indirect immunofluorescence assay (IFA). Molecular tests are applied only by a few researchers. Evaluation of a new commercial real time polymerase chain reaction (PCR) kit for molecular diagnosis of ST by comparing it with the commonly used IgM ELISA is our aim. ST has been reported all over India including Puducherry and surrounding Tamil Nadu and identified as endemic for ST. This study was designed to correlate antibody detection by IgM ELISA and Orientia tsutsugamushi DNA in real time PCR. ST IgM ELISA (InBios Inc., USA) was carried out for 170 consecutive patients who presented with the symptoms of acute ST during 11 months (November, 2015- September, 2016). All 77 of these patients with IgM ELISA positivity and 49 of 93 IgM ELISA negative patients were subjected to real time PCR (Geno-Sen's ST real time PCR, Himachal Pradesh, India). Statistical analysis for clinical and laboratory results was performed using IBM SPSS Statistics 17 for Windows (SPSS Inc., Chicago, USA). Chi-square test with Yates correction (Fisher's test) was employed for a small number of samples. Among 77 suspected cases of acute ST with IgM ELISA positivity and 49 IgM negative patients, 42 and 7 were positive, respectively, for O. tsutsugamushi 56-kDa type-specific gene in real time PCR kit. Until ST IFA, the gold standard diagnostic test, is properly validated in India, diagnosis of acute ST will depend on both ELISA and quantitative PCR.

Validation of the VBLaST peg transfer task: a first step toward an alternate training standard.

PubMed

Chellali, A; Zhang, L; Sankaranarayanan, G; Arikatla, V S; Ahn, W; Derevianko, A; Schwaitzberg, S D; Jones, D B; DeMoya, M; Cao, C G L

2014-10-01

The FLS trainer lacks objective and automated assessments of laparoscopic performance and requires a large supply of relatively expensive consumables. Virtual reality simulation has a great potential as a training and assessment tool of laparoscopic skills and can overcome some limitations of the FLS trainer. This study was carried out to assess the value of our Virtual Basic Laparoscopic Surgical Trainer (VBLaST(©)) in the peg transfer task compared to the FLS trainer and its ability to differentiate performance between novice, intermediate, and expert groups. Thirty subjects were divided into three groups: novices (PGY1-2, n = 10), intermediates (PGY3-4, n = 10), and experts (PGY5, surgical fellows and attendings, n = 10). All subjects performed ten trials of the peg transfer task on each simulator. Assessment of laparoscopic performance was based on FLS scoring while a questionnaire was used for subjective evaluation. The performance scores in the two simulators were correlated, though subjects performed significantly better in the FLS trainer. Experts performed better than novices only on the FLS trainer while no significant differences were observed between the other groups. Moreover, a significant learning effect was found on both trainers, with a greater improvement of performance on the VBLaST(©). Finally, 82.6% of the subjects preferred the FLS over the VBLaST(©) for surgical training which could be attributed to the novelty of the VR technology and existing deficiencies of the user interface for the VBLaST(©). This study demonstrated that the VBLaST(©) reproduced faithfully some aspects of the FLS peg transfer task (such as color, size, and shape of the peg board, etc.) while other aspects require additional development. Future improvement of the user interface and haptic feedback will enhance the value of the system as an alternative to the FLS as the standard training tool for laparoscopic surgery skills.

Simultaneous assessment of contact pressure and local electrical coupling index using robotic navigation.

PubMed

Dello Russo, Antonio; Fassini, Gaetano; Casella, Michela; Bologna, Fabrizio; Al-Nono, Osama; Colombo, Daniele; Biagioli, Viviana; Santangeli, Pasquale; Di Biase, Luigi; Zucchetti, Martina; Majocchi, Benedetta; Marino, Vittoria; Gallinghouse, Joseph J; Natale, Andrea; Tondo, Claudio

2014-06-01

Contact with cardiac tissue is a determinant of lesion efficacy during atrial fibrillation (AF) ablation. The Sensei®X Robotic Catheter System (Hansen Medical, CA) has been validated for contact force sensing. The electrical coupling index (ECI) from the EnSite Contact™ system (St. Jude Medical, MN) has been validated as an indicator of tissue contact. We aimed at analyzing ECI behavior during radiofrequency (RF) pulses maintaining a stable contact through the robotic navigation contact system. In 15 patients (age, 59 ± 12) undergoing AF ablation, pulmonary vein (PV) isolation was guided by the Sensei®X System, employing the Contact™ catheter. During the procedure, we assessed ECI changes associated with adequate contact based on the IntelliSense® force-sensing technology (Hansen Medical, CA. Baseline contact (27 ± 8 g/cm(2)) ECI value was 99 ± 13, whereas ECI values in a noncontact site (0 g/cm(2)) and in a light contact site (1-10 g/cm(2)) were respectively 66 ± 12 and 77 ± 10 (p < 0.0001). Baseline contact ECI values were not different depending on AF presentation (paroxysmal AF, 98 ± 9; persistent AF, 100 ± 9) or on cardiac rhythm (sinus rhythm, 97 ± 7; AF,101 ± 10). In all PVs, ECI was significantly reduced during and after ablation (ECI during RF, 56 ± 15; ECI after RF, 72 ± 16; p < 0.001). A mean reduction of 32.2% during RF delivery and 25.4% immediately after RF discontinuation compared with baseline ECI was observed. Successful PV isolation is associated with a significant decrease in ECI of at least 20 %. This may be used as a surrogate marker of effective lesion in AF ablation.

Quantifying High Frequency Skill and Relative Cost of Two Physics Packages for an Operational Spectral Wave Model

NASA Astrophysics Data System (ADS)

Edwards, K. L.; Siqueira, S. A.; Rogers, W. E.

2017-12-01

Simulating WAves Nearshore (SWAN) is one of the two phase-averaged spectral models used by the U.S. Navy for forecasting waves. The source term package available during SWAN's first validation for operational use in 2002 is referred to here as "SWAN-ST1". Since then, improvements to the source term package were implemented (SWAN-ST6). One outcome of the new package is better skill within the higher frequencies of the spectrum, where SWAN-ST1 gives non-physical response to changes in wind speed and non-physical response to presence of swell in the lower frequencies. However, SWAN-ST6 is typically 25% more expensive computationally than SWAN-ST1, so it is worthwhile to estimate its benefit to operational cases, where computation time is a primary concern. To validate SWAN-ST6 and quantify its improvement over SWAN-ST1, we apply the model to two geographic regions—the Northern Gulf of Mexico (NGoM) and Southern California (SoCal) coasts. The NGoM case is typified by smaller fetch and smaller swell contribution. We analyze the NGoM case for a year (2010 July-2011 Aug.); and the SoCal application for summer (2016 July-Aug.) and winter (2017 Jan.-Feb.) seasons. We compare results to available buoy data. The wave parameter mean square slope (MSS) is included in this study, since it is sensitive to accuracy (or lack thereof) at higher frequencies, as it is weighted by frequency to the fourth power. Model-data comparisons for the NGoM case show little benefit to using SWAN-ST6; both models highly correlate with observations, a result attributable to a) the lack of swell and b) the fact that the shorter dominant periods in this basin imply that available buoys typically measure very little of the spectral tail (e.g. 2 to 4 times the peak frequency). Model-data comparisons for the SoCal test case show that SWAN-ST6 performs at least as well but most often better than SWAN-ST1. The improvement is almost negligible for the lower order moments, significant wave height and period, which are less sensitive to the spectral tail. However, SWAN-ST6 in the SoCal case dramatically improves the comparisons of MSS relative to SWAN-ST1. Thus, results show that, in cases where the wave climate and frequency range of buoy data permit validation of the spectral tail, skill of MSS prediction is dramatically improved with the new source term package.

Clonal Spread of Levofloxacin-Resistant Streptococcus pneumoniae Invasive Isolates in Madrid, Spain, 2007 to 2009▿

PubMed Central

Rodríguez-Avial, Iciar; Ramos, Belén; Ríos, Esther; Cercenado, Emilia; Ordobás, María; Sanz, Juan Carlos

2011-01-01

Among 1,349 Streptococcus pneumoniae invasive isolates, 45 (3.3%) were levofloxacin resistant. Serotype distribution was as follows: 8 (n = 32 isolates), 19A (n = 4 isolates), 7F (n = 3 isolates), 9V (n = 2 isolates), 10A (n = 1 isolate), 19F (n = 1 isolate), 6B (n = 1 isolate), and nontypeable (n = 1 isolate). Levofloxacin-resistant isolates had dual mutations in the gyrA and parC genes. Serotype 8 strains corresponded to a capsular switching of the Sweden15A-25 clone. Levofloxacin resistance was also detected among multiresistant (ST27619A, Spain9V-ST156, ST8819F, and ST15426B) and among usually antibiotic-susceptible (Netherlands7F-ST191, ST120119A, and ST263910A) clones. PMID:21383091

Electrocardiography as a Tool for Validating Myocardial Ischemia–Reperfusion Procedures in Mice

PubMed Central

Preda, Mihai B; Burlacu, Alexandrina

2010-01-01

This paper evaluates the modifications induced by ischemia and ischemia–reperfusion in mice after permanent or transient, respectively, ligation of the left coronary artery and establishes a correlation among the extent of ischemia, electrocardiograph features, and infarct size. The left coronary artery was ligated 1 mm distal from the tip of the left auricle. Histologic analysis revealed that 30-min ischemia (n = 9) led to infarction involving 9.7% ± 0.5% of the left ventricle, whereas 1-h ischemia (n = 9) resulted in transmural infarction of 16.1% ± 4.6% of the left ventricle. In contrast, 24-h ischemia (n = 8) and permanent ischemia (n = 8) induced similarly sized infarcts (33% ± 2% and 31.8% ± 0.7%, respectively), suggesting ineffective reperfusion after 24-h ischemia. Electrocardiography revealed that ligation of the left coronary artery led to ST height elevation (204 compared with 14 μV) and QTc prolongation (136 compared with 76 ms). Both parameters rapidly normalized on reperfusion, demonstrating that electrocardiography was important for validating correct ligation and reperfusion. In addition, electrocardiography predicted the severity of the myocardial damage induced by ischemia. Our results show that electrocardiographic changes present after 30-min ischemia were reversed on reperfusion; however, prolonged ischemia induced pathologic electrocardiographic patterns that remained even after reperfusion. The mouse model of myocardial ischemia–reperfusion can be improved by using electrocardiography to validate ligation and reperfusion during surgery and to predict the severity of infarction. PMID:21262130

Advanced Information Processing System (AIPS)

NASA Technical Reports Server (NTRS)

Pitts, Felix L.

1993-01-01

Advanced Information Processing System (AIPS) is a computer systems philosophy, a set of validated hardware building blocks, and a set of validated services as embodied in system software. The goal of AIPS is to provide the knowledgebase which will allow achievement of validated fault-tolerant distributed computer system architectures, suitable for a broad range of applications, having failure probability requirements of 10E-9 at 10 hours. A background and description is given followed by program accomplishments, the current focus, applications, technology transfer, FY92 accomplishments, and funding.

Ada (Tradename) Compiler Validation Summary Report. Harris Corporation. Harris Ada Compiler, Version 1.0. Harris HCX-7.

DTIC Science & Technology

1986-06-12

owp-fts 677 RDA (TRRDENE) COMPILER VALIDATION SUMAY REPORT III HARRIS CORPORATION MAR.. (U) INFORMATION SYSTEMS AM TECHNOLOGY CENTER N-P AFI OM ADA...Subtitle) 5. TYPE OF REPORT & PERIOD COVERED Ada Compiler Validation Summary Report : 12 .UN 1986 to 12 JUN1 1987 Harris Corporation, Harris Ada Compiler...Version 1.0, Harris HCX-7 6. PERFORMING ORG. REPORT NUMBER 7. AUTHOR(s) 8. CONTRACT OR GRANT NUMBERs) Wright-Patterson 9. PERFORMING ORGANIZATION AND

Cell recognition molecule L1 promotes embryonic stem cell differentiation through the regulation of cell surface glycosylation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Ying; Department of Clinical Laboratory, Second Affiliated Hospital of Dalian Medical University, Dalian 116023; Huang, Xiaohua

2013-10-25

Highlights: •Down-regulating FUT9 and ST3Gal4 expression blocks L1-induced neuronal differentiation of ESCs. •Up-regulating FUT9 and ST3Gal4 expression in L1-ESCs depends on the activation of PLCγ. •L1 promotes ESCs to differentiate into neuron through regulating cell surface glycosylation. -- Abstract: Cell recognition molecule L1 (CD171) plays an important role in neuronal survival, migration, differentiation, neurite outgrowth, myelination, synaptic plasticity and regeneration after injury. Our previous study has demonstrated that overexpressing L1 enhances cell survival and proliferation of mouse embryonic stem cells (ESCs) through promoting the expression of FUT9 and ST3Gal4, which upregulates cell surface sialylation and fucosylation. In the present study,more » we examined whether sialylation and fucosylation are involved in ESC differentiation through L1 signaling. RNA interference analysis showed that L1 enhanced differentiation of ESCs into neurons through the upregulation of FUT9 and ST3Gal4. Furthermore, blocking the phospholipase Cγ (PLCγ) signaling pathway with either a specific PLCγ inhibitor or knockdown PLCγ reduced the expression levels of both FUT9 and ST3Gal4 mRNAs and inhibited L1-mediated neuronal differentiation. These results demonstrate that L1 promotes neuronal differentiation from ESCs through the L1-mediated enhancement of FUT9 and ST3Gal4 expression.« less

Evaluation of the yield, molar mass of exopolysaccharides, and rheological properties of gels formed during fermentation of milk by Streptococcus thermophilus strains St-143 and ST-10255y.

PubMed

Khanal, Som N; Lucey, John A

2017-09-01

The yield and chemical structures of exopolysaccharides (EPS) produced by many strains of Streptococcus thermophilus have been characterized. However, the kinetics (or production profile) for EPS during milk fermentation is not clear. In this study, we investigated whether any differences existed in the yield and molar mass of EPS when milk was fermented at the same acidification rate by 2 strains of S. thermophilus (St-143 and ST-10255y). The type of EPS produced by these 2 strains is different. Milk samples were analyzed for EPS concentration every 30 min during a fermentation period of 270 min (final pH 4.5) by using a modified quantification method, which was faster and validated for its recovery of added EPS. Rheological properties of milks during fermentation were also analyzed using small-strain dynamic oscillatory rheology. For the determination of molar mass, EPS extracts were isolated by ultrafiltration of whey obtained during fermentation of milk to pH values 5.2, 4.9, 4.7, and 4.5, and molar mass was analyzed using size-exclusion chromatography-multi-angle laser light scattering. During fermentation, both strains appeared to start producing significant amounts of EPS after about ∼150 min, which corresponded to pH ∼5.3, which was close to the point of gelation. During the remainder of the fermentation process (150-270 min), the EPS concentration from strains St-143 and ST-10255y significantly increased from 30 to 72 mg/L and from 26 to 56 mg/L, respectively. The quantity of EPS recovered by our modified method was estimated to represent ∼60% of the total EPS added to milk. The molar mass of EPS produced by both strains appeared to slightly decrease during fermentation. At pH 5.2, EPS from St-143 and ST-10255y had molar masses of 2.9 × 10 6 and 1.4 × 10 6 g/mol, respectively, which decreased to 1.6 × 10 6 and 0.8 × 10 6 g/mol, respectively, when the pH of milk was 4.5. Distinct differences were apparent in the rheological properties of gels fermented by the 2 strains. At the end of fermentation, St-143 fermented milk had weaker gels with storage modulus (G') value at pH 4.6 of 26 Pa, whereas gels made with ST-10255y were stiffer with a G' value at pH 4.6 of 82 Pa. For St-143 gels, maximum loss tangent (LT max ) values were higher (0.50) and occurred earlier (at a higher pH value) than the LT max values (0.46) for gels from ST-10255y strain. Because the fermentation conditions were identical for both strains, the observed changes in rheological properties could be due to the differences in chemical structures and molar mass of the EPS produced by these 2 S. thermophilus strains. Copyright © 2017 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Past, present, and future of sublimation transfer imaging

NASA Astrophysics Data System (ADS)

Akada, Masanori

1990-07-01

SONY's announcement of tlavica system shaked the world in 1981. In the new nonphotographic imaging system, image is acquired with CCD to be converted into electric image-signal, stored in magnetic recording media,displayed on a CR1 and printed on a special sheet. To get a hard copy, Sublimation Transfer technology was developed. That announcement brought about world-wide R&D of competitive color imaging systems: Ink-jet, Wax transfer,. Sublimation Transfer(ST) and Electrophotography. In spite of much effort,most of those were insufficient for getting a good hard copy. Developing sufficient ST recording media, Dai Nippon Printing started ST recording media business in 1986. It was the first manufacturing scale production and sale of ST recording media in the world. Nowadays ST technology is known for its advantages: high image quality, consistency from copy to copy, smooth tone-reproduction from high-light to maximum density, and easiness to use. In the following paper progress of ST recording media and the present situation and future markets of the media will be presented.

Validation of a Measure of Normative Beliefs About Smokeless Tobacco Use.

PubMed

Adkison, Sarah E; O'Connor, Richard J; Bansal-Travers, Maansi; Cummings, K Michael; Rees, Vaughan W; Hatsukami, Dorothy K

2016-05-01

Validated methods to evaluate consumer responses to modified risk tobacco products (MRTPs) are needed. Guided by existing literature that demonstrates a relationship between normative beliefs and future intentions to use tobacco the current research sought to (1) develop a measure of normative beliefs about smokeless tobacco (ST) and establish the underlying factor structure, (2) evaluate the structure with confirmatory factor analysis utilizing an independent sample of youth, and (3) establish the measure's concurrent validity. Respondents (smokers and nonsmokers aged 15-65; N = 2991) completed a web-based survey that included demographic characteristics, tobacco use history and dependence, and a measure of attitudes about ST adapted from the Normative Beliefs about Smoking scale. A second sample of youth (aged 14-17; N = 305) completed a similar questionnaire. Exploratory factor analysis produced the anticipated three-factor solution and accounted for nearly three-quarters of the variance in the data reflecting (1) perceived prevalence of ST use, (2) popularity of ST among successful/elite, and (3) approval of ST use by parents/peers. Confirmatory factor analysis with data from the youth sample demonstrated good model fit. Logistic regression demonstrated that the scales effectively discriminate between ST users and nonusers and are associated with interest in trying snus. Assessment of MRTPs for regulatory purposes, which allows messages of reduced risk, should include measurement of social norms. Furthermore, surveillance efforts that track use of new MRTPs should include measures of social norms to determine how norms change with prevalence of use. © The Author 2015. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Identify and validate a quantitative trait locus underlying stearic acid on chromosome 14 in a soybean landrace using recombinant inbred lines and resident heterozygous lines

USDA-ARS?s Scientific Manuscript database

Stearic acid (ST) is one of the saturated fatty acids (FAs) in soybean oil and great efforts have been made to elevate ST content through plant breeding. Improving ST content will be helpful to reduce the health risk of coronary heart diseases and breast, colon and prostate cancer. In this study, re...

18-Degree-of-Freedom Controller Design for the ST7 Disturbance Reduction System

NASA Technical Reports Server (NTRS)

Markley, F. L.; Maghami, P. G.; Houghton, M. B.; Hsu, O. C.

2003-01-01

The Space Technology 7 experiment will perform an on-orbit system-level validation of a Disturbance Reduction System employing gravitational reference sensors and micronewton colloidal thrusters to maintain a spacecraft s position with respect to free-floating test masses in the gravitational reference sensors to less than 10 nm/dHz over the frequency range 1 to 30 mHz. This paper presents the design and analysis of the control system that closes the loop between the gravitational reference sensors and the micronewton thrusters while incorporating star tracker data at low frequencies. The effects of disturbances and actuation and measurement noise are evaluated in a eighteen-degree-of-freedom model.

The Next Frontier in Making Disciples: 21st-Century Technology Use in CCCU Member Institutions

ERIC Educational Resources Information Center

Boden, Karen E.

2012-01-01

An unprecedented opportunity exists for Christian colleges and universities to utilize 21st-century technology and the impact of globalization to broaden the use of distance learning for missional purposes through their educational offerings. Some institutions offer open education that allows those with Internet access to take courses at no cost…

U.S. Competitiveness in Science and Technology

ERIC Educational Resources Information Center

Galama, Titus; Hosek, James

2008-01-01

The purpose of this report is to present and consider information related to whether the United States is losing its edge in science and technology (S&T). The report cites arguments made to support the contention of a creeping S&T crisis in the United States, contrasts the arguments with relevant data, and considers them from additional…

Developing Peer Mentoring Support for TAFE Students Entering 1st-Year University Early Childhood Studies

ERIC Educational Resources Information Center

Heirdsfield, Ann; Walker, Sue; Walsh, Kerryann

2005-01-01

At Queensland University of Technology (QUT, Australia), in the Bachelor of Education (BEd) (Early Childhood) (EC), Technical and Further Education (TAFE) students with a diploma enroll with advanced standing (1 year's credit). These students share many challenges faced by 1st-year university students--workload, technology, academic orientation,…

The Connection to the 21st Century Workforce: Technology and Engineering Education

ERIC Educational Resources Information Center

International Technology and Engineering Educators Association, 2011

2011-01-01

Building a competitive workforce for the 21st Century requires the careful alignment of K-12 and university curricula with the skill needs of business and industry. In addition to making students better problem solvers, critical thinkers, and users of technology, academic preparation must instill in them the desire to become lifelong learners,…

Transforming Pedagogies: Integrating 21st Century Skills and Web 2.0 Technology

ERIC Educational Resources Information Center

Tucker, Shelia Y.

2014-01-01

According to (P21), Partnership for 21st Century Skills (n.d.), unless the gap is bridged between how students learn and how they live, today's education system will face irrelevance. The way people work and live has been transformed by demographic, economic, political, technological, and informational forces. Schools must adapt to these…

Technology: A Position Statement of National Council for the Social Studies

ERIC Educational Resources Information Center

Social Education, 2013

2013-01-01

Technological change has proven one of the few constants of the early 21st century, providing social studies educators with the challenge and opportunity of preparing digital citizens in a global setting. This requires rethinking the type of social studies learning necessary in the 21st century. As the National Academies concluded in the…

Evolving Technologies Require Educational Policy Change: Music Education for the 21st Century

ERIC Educational Resources Information Center

Crawford, Renee

2013-01-01

There is growing discussion among education and government authorities on rethinking education in the 21st century. This increasing area of interest has come in response to the evolution of technology and its effect on the future needs and requirements of society. Online applications and social networking capabilities have accelerated in…

Investigating the Key Attributes to Enhance Students' Learning Experience in 21st Century Class Environment

ERIC Educational Resources Information Center

Leow, Fui-Theng; Neo, Mai; Hew, Soon Hin

2016-01-01

The 21st century marks the beginning of digital age with the extensive use of digital media, mobile devices, and Internet resources. Recent studies found that this digital era has expanded the landscape of student experiences, and educational technologies as well as increased the educator's awareness on embracing technologies to promote effective…

Standards for the 21st-Century Learner: Comparisons with NETS and State Standards

ERIC Educational Resources Information Center

Pappas, Marjorie

2008-01-01

The American Association of School Librarians (AASL) and the International Society for Technology in Education (ISTE) have both recently launched new standards. These are known as the "AASL Standards for the 21st-Century Learner" and "The National Educational Technology Standards for Students: The Next Generation" (NETS). The standards from each…

Distance Learning in the 21st Century University: Key Issues for Leaders and Faculty

ERIC Educational Resources Information Center

Amirault, Ray J.

2012-01-01

The changes precipitated by today's computer-based technologies are perhaps no more keenly felt than in the field of education, where technological innovation signals fundamental transformations in the manner in which educational programs will be delivered to 21st century students. Online learning is providing higher education institutions with an…

Impact of Multimedia Based Instructional Design on the College Students

ERIC Educational Resources Information Center

Ramganesh, E.; Amutha, S.

2011-01-01

Preparing the technology proficient learners to meet the needs of 21st century has emerged as a critical challenge facing education in our country. The teacher has to prepare the young generation to fit in to the technology intensive society of the 21st century. Instructional design (ID) is the systematic process of planning events to facilitate…

Cyberbullying and Sexting: Technology Abuses of the 21st Century

ERIC Educational Resources Information Center

Siegle, Del

2010-01-01

Many young people cannot remember a time before Instant Messaging (IM), cell phone text messaging, video conferencing, blogging, e-mailing, and MySpace and Facebook postings existed. Thanks to the ubiquitous nature of technology in the 21st century, digital natives are accustomed to seeing, and being seen, on a scale that was unimaginable by their…

Mount St. Helens: A 30-year legacy of volcanism

USGS Publications Warehouse

Vallance, James W.; Gardner, Cynthia A.; Scott, William E.; Iverson, Richard M.; Pierson, Thomas C.

2010-01-01

The spectacular eruption of Mount St. Helens on 18 May 1980 electrified scientists and the public. Photodocumentation of the colossal landslide, directed blast, and ensuing eruption column—which reached as high as 25 kilometers in altitude and lasted for nearly 9 hours—made news worldwide. Reconnaissance of the devastation spurred efforts to understand the power and awe of those moments (Figure 1). The eruption remains a seminal historical event—studying it and its aftermath revolutionized the way scientists approach the field of volcanology. Not only was the eruption spectacular, but also it occurred in daytime, at an accessible volcano, in a country with the resources to transform disaster into scientific opportunity, amid a transformation in digital technology. Lives lost and the impact of the eruption on people and infrastructure downstream and downwind made it imperative for scientists to investigate events and work with communities to lessen losses from future eruptions.

Overcoming the S&T Assessment Uncertainty Principle: An Approach to Enterprise-Wide Assessment of the DOD S&T Program

DTIC Science & Technology

2006-09-01

expected advancements in information technology and library science offer the best hope of resolving the above concerns. vi • An EWA will be...information technology and library science must be utilized to accomplish this. Some DOD research investment may be required to resolve DOD specific...distributed assessment process that exploits the documentation of all of the CEST issues, advances in information technology and library science , and the

A Future State for NASA Laboratories - Working in the 21st Century

NASA Technical Reports Server (NTRS)

Kegelman, Jerome T.; Harris, Charles E.; Antcliff, Richard R.; Bushnell, Dennis M.; Dwoyer, Douglas L.

2009-01-01

The name "21 st Century Laboratory" is an emerging concept of how NASA (and the world) will conduct research in the very near future. Our approach is to carefully plan for significant technological changes in products, organization, and society. The NASA mission can be the beneficiary of these changes, provided the Agency prepares for the role of 21st Century laboratories in research and technology development and its deployment in this new age. It has been clear for some time now that the technology revolutions, technology "mega-trends" that we are in the midst of now, all have a common element centered around advanced computational modeling of small scale physics. Whether it is nano technology, bio technology or advanced computational technology, all of these megatrends are converging on science at the very small scale where it is profoundly important to consider the quantum effects at play with physics at that scale. Whether it is the bio-technology creation of "nanites" designed to mimic our immune system or the creation of nanoscale infotechnology devices, allowing an order of magnitude increase in computational capability, all involve quantum physics that serves as the heart of these revolutionary changes.

Use of near-infrared spectroscopy (NIRS) in cerebral tissue oxygenation monitoring in neonates.

PubMed

Gumulak, Rene; Lucanova, Lucia Casnocha; Zibolen, Mirko

2017-06-01

Near-infrared spectroscopy (NIRS) is a technology capable of non-invasive, continuous measuring of regional tissue oxygen saturation (StO 2 ). StO 2 represents a state of hemodynamic stability, which is influenced by many factors. Extensive research has been done in the field of measuring StO 2 of various organs. The current clinical availability of several NIRS-based devices reflects an important development in prevention, detection and correction of discrepancy in oxygen delivery to the brain and vital organs. Managing cerebral ischemia remains a significant issue in the neonatal intensive care units (NICU). Cerebral tissue oxygenation (cStO 2 ) and cerebral fractional tissue extraction (cFTOE) are reported in a large number of clinical studies. This review provides a summary of the concept of function, current variability of NIRS-based devices used in neonatology, clinical applications in continuous cStO 2 monitoring, limitations, disadvantages, and the potential of current technology.

Diatomite

USGS Publications Warehouse

Crangle, R.D.

2013-01-01

The United States continues to be the world’s leading producer and consumer of diatomite. Production of diatomite in the United States during 2012 was estimated to be 820 kt (903,000 st), a slight increase compared with 2011 production. The unit value of diatomite varied widely by end use in 2012. Diatomite used as a lightweight aggregate was priced at $11/t ($9.98/st), while specialty-grade diatomite, used in art supplies, cosmetics, or biomedical applications, could be priced as high as $10,000/t ($9,000/st). Filter-grade diatomite had an average unit value of $330/t ($299/st). Seven companies operated 10 mines and nine processing facilities in California, Nevada, Oregon and Washington. U.S. diatomite exports totaled about 96 kt (106,000 st). Imports were much lower at approximately 3.07 kt (3,380 st).

Development of a Modeling Framework to Support Control Investigations of Sailcraft Missions A First Cut: ABLE Sailcraft Dynamics Model

NASA Technical Reports Server (NTRS)

Sarathy, Sriprakash

2005-01-01

Solar Sailcraft, the stuff of dreams of the H.G. Wells generation, is now a rapidly maturing reality. The promise of unlimited propulsive power by harnessing stellar radiation is close to realization. Currently, efforts are underway to build, prototype and test two configurations. These sails are designed to meet a 20m sail requirement, under guidance of the In-Space Propulsion (ISP) technology program office at MSFC. While these sails will not fly , they are the first steps in improving our understanding of the processes and phenomena at work. As part of the New Millennium Program (NMP) the ST9 technology validation mission hopes to launch and fly a solar sail by 2010 or sooner. Though the Solar Sail community has been studying and validating various concepts over two decades, it was not until recent breakthroughs in structural and material technology, has made possible to build sails that could be launched. With real sails that can be tested (albeit under earth conditions), the real task of engineering a viable spacecraft has finally commenced. Since it is not possible to accurately or practically recreate the actual operating conditions of the sailcraft (zero-G, vacuum and extremely low temperatures), much of the work has focused on developing accurate models that can be used to predict behavior in space, and for sails that are 6-10 times the size of currently existing sails. Since these models can be validated only with real test data under "earth" conditions, the process of modeling and the identification of uncertainty due to model assumptions and scope need to be closely considered. Sailcraft models that exist currently, are primarily focused on detailed physical representations at the component level, these are intended to support prototyping efforts. System level models that cut across different sail configurations and control concepts while maintaining a consistent approach are non-existent. Much effort has been focused on the areas of thrust performance, solar radiation prediction, and sail membrane behavior vis-a-vis their reflective geometry, such as wrinkling/folding/furling as it pertains to thrust prediction. A parallel effort has been conducted on developing usable models for developing attitude control systems (ACS), for different sail configurations in different regimes. There has been very little by way of a system wide exploration of the impact of the various control schemes, thrust prediction models for different sail configurations being considered.

Effects of treatment of periparturient dairy cows with recombinant bovine somatotropin on health and productive and reproductive parameters.

PubMed

Silva, P R B; Soares, H F; Braz, W D; Bombardelli, G D; Clapper, J A; Keisler, D H; Chebel, R C

2017-04-01

The objectives of the current experiment were to evaluate the effects of treating periparturient dairy cows with recombinant bovine somatotropin (rbST) on incidence of postpartum diseases and performance. Holstein (HO) and Jersey (JS) cows from 2 herds were enrolled in the experiment at 253 ± 3 d of gestation and assigned to the control (n = 432) and rbST125 (n = 437) treatments. Cows in the rbST125 treatment received 125 mg of rbST, weekly, from -21 to 21 d relative to calving. Blood sampled weekly, from -21 to 21 d relative to calving, from a subsample of cows was used to determine the concentrations of growth hormone (GH, HO = 106) and insulin-like growth factor 1 (IGF-1, HO = 147 and JS = 49). Cows were scored for body condition (BCS) at enrollment and at 1 ± 3, 30 ± 3, and 60 ± 3 d in milk (DIM). Cows were milked thrice daily and energy-corrected milk (ECM) yield was recorded for the first 30 DIM. Treatment of cows with rbST resulted in greater concentrations of GH during the prepartum (log 10 back-transformed concentrations of GH: HO-control = 7.83 and HO-rbST125 = 10.36 ng/mL) and postpartum (log 10 back-transformed concentrations of GH: HO-control = 10.45 and HO-rbST125 = 18.47 ng/mL) periods. Similarly, IGF-1 concentrations were higher during the prepartum (HO-control = 115.1 ± 4.9, HO-rbST125 = 137.7 ± 4.7, JS-control = 120.2 ± 8.3, JS-rbST125 = 167.1 ± 8.1 ng/mL) and postpartum (HO-control = 61.3 ± 4.0, HO-rbST125 = 75.2 ± 3.8, JS-control = 35.5 ± 6.9, JS-rbST125 = 54.6 ± 6.9 ng/mL) periods for rbST-treated cows. During the prepartum period, BCS was not affected by treatment, but during the postpartum period, BCS was reduced for rbST-treated cows (HO-control = 3.00 ± 0.03, HO-rbST125 = 2.90 ± 0.03, JS-control = 2.64 ± 0.02, JS-rbST125 = 2.61 ± 0.02). Cows from the rbST125 treatment tended to have lower incidence of retained fetal membranes (HO-control = 14.3, HO-rbST125 = 6.1, JS-control = 1.5, JS-rbST125 = 1.2%) and had reduced incidence of metritis (HO-control = 26.2, HO-rbST125 = 16.6, JS-control = 19.9, JS-rbST125 = 13.3%) compared with control cows. Ketosis incidence tended to be higher for rbST125 cows (HO-control = 9.4, HO-rbST125 = 11.3, JS-control = 8.5, JS-rbST125 = 13.4%) compared with control cows. The interaction between treatment and herd tended to affect yield of ECM during the first 30 DIM because HO cows treated with rbST during the periparturient period had greater yield than control HO cows (HO-control = 35.5 ± 1.0 vs. HO-rbST125 = 39.4 ± 1.0 kg/d), but treatment with rbST did not affect yield of ECM of JS cows (JS-control = 26.7 ± 0.6 vs. JS-rbST125 = 27.8 ± 0.6 kg/d). Treatment of periparturient dairy cows with 125 mg of rbST decreased the incidence of uterine disorders in HO and JS cows and increased yield of ECM during the first 30 DIM among HO cows, despite slightly increasing the incidence of ketosis. Copyright © 2017 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Application of mid-infrared spectroscopy to the prediction of maturity and sensory texture attributes of cheddar cheese.

PubMed

Fagan, C C; O'Donnell, C P; O'Callaghan, D J; Downey, G; Sheehan, E M; Delahunty, C M; Everard, C; Guinee, T P; Howard, V

2007-04-01

The objective of this study was to determine the potential of mid-infrared spectroscopy in conjunction with partial least squares (PLS) regression to predict various quality parameters in cheddar cheese. Cheddar cheeses (n= 24) were manufactured and stored at 8 degrees C for 12 mo. Mid-infrared spectra (640 to 4000/cm) were recorded after 4, 6, 9, and 12 mo storage. At 4, 6, and 9 mo, the water-soluble nitrogen (WSN) content of the samples was determined and the samples were also evaluated for 11 sensory texture attributes using descriptive sensory analysis. The mid-infrared spectra were subjected to a number of pretreatments, and predictive models were developed for all parameters. Age was predicted using scatter-corrected, 1st derivative spectra with a root mean square error of cross-validation (RMSECV) of 1 mo, while WSN was predicted using 1st derivative spectra (RMSECV = 2.6%). The sensory texture attributes most successfully predicted were rubbery, crumbly, chewy, and massforming. These attributes were modeled using 2nd derivative spectra and had corresponding RMSECV values in the range of 2.5 to 4.2 on a scale of 0 to 100. It was concluded that mid-infrared spectroscopy has the potential to predict age, WSN, and several sensory texture attributes of cheddar cheese.

9. Historic American Buildings Survey, Arthur C. Haskell, Photographer. April, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Historic American Buildings Survey, Arthur C. Haskell, Photographer. April, 1934. (e) Before- Looking south along Summer St. from Merrimack St. - Highway Cut-off Demolition Area, Summer, Winter, High & Merrimac Streets, Newburyport, Essex County, MA

9. Photocopy of postcard (from Benicia Historical Society) Frank J. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Photocopy of postcard (from Benicia Historical Society) Frank J. Stumm, Photographer ca. 1908-16 'ST. DOMINIC'S CHURCH AT XMAS TIME,' INTERIOR - St. Dominic's Catholic Church, 475 East I Street, Benicia, Solano County, CA

Validation of a visual analogue score (LRTI-VAS) in non-CF bronchiectasis.

PubMed

Altenburg, Josje; Wortel, Kim; de Graaff, Casper S; van der Werf, Tjip S; Boersma, Wim G

2016-03-01

Quality of life in patients with non-cystic fibrosis (non-CF) bronchiectasis is largely defined by respiratory symptoms. To date, no disease-specific tool for symptom measurement in this patient group was available. We developed the lower respiratory tract infections - visual analogue scale (LRTI-VAS) in order to quickly and conveniently quantify symptoms in non-CF bronchiectasis. This study aimed to validate LRTI-VAS for use in non-CF bronchiectasis. This study included outpatients with radiologically proven bronchiectasis and no evidence of CF. Results of LRTI-VAS were compared with other markers of disease activity {lung function parameters, oxygen saturation and three health-related quality of life questionnaires [Medical Outcomes Study Short-Form 36 Health Survey (SF-36), St Georges Respiratory Questionnaire (SGRQ) and Leicester Cough Questionnaire (LCQ)]} and validity, reliability and responsiveness were assessed. Thirty stable and 30 exacerbating participants completed the LRTI-VAS questionnaire. When testing for repeatability on two separate occasions, no statistically significant difference between total scores was found {1.4 [standard deviation (SD)] 5.3}, P = 0.16). Internal consistency was high across items (Cronbach's alpha 0.86). Correlation with SGRQ, SF-36 and LCQ total scores was high. Following antibiotic treatment, mean (SD) LRTI-VAS total score improved from 18.1 (SD 9.9) to 26.1 (SD 6.6) (P < 0.001). LRTI-VAS showed excellent validity, reliability and responsiveness to change and therefore appears a reliable tool for symptom measurement in non-CF bronchiectasis. © 2014 John Wiley & Sons Ltd.

Fundamentals of Friction: Macroscopic and Microscopic Processes. Proceedings of the NATO Advanced Study Institute on Fundamentals of Friction Held In Germany on July 29 - August 9, 1991

DTIC Science & Technology

1991-08-09

processes Prof T E Fischer, Stevens Institute of Technology, Hoboken, USA. Friction of granular materials Dr M J Adams, Unilever Research, Wirral, England...Army Research Office, ERO US National Science Foundation US Office of Naval Research, ERO Unilever Research and Engineering Division Mobil Research and...Development Corporation Exxon Research and Engineering Company . We are especially grateful to the ASI Administrator, Mr M G de St V Atkins, who was

Development of Medical Technology for Contingency Response to Marrow Toxic Agents Held January 1, 2009 Through March 31, 2009

DTIC Science & Technology

2009-05-11

incorporating both allele and epitope level matching for HLA-DPB1. Accepted for oral presenation. o Z Shamim , L Ryder, M Haagenson , S Spellman, T Wang, S ...PROJECT NUMBER N/A 5e. TASK NUMBER Project 1, 2, 3, 4 6. AUTHOR( S ) Setterholm, Michelle 5f. WORK UNIT NUMBER N/A 7. PERFORMING ORGANIZATION NAME( S ...N/A 10. SPONSOR/MONITOR’S ACRONYM( S ) ONR 9. SPONSORING/MONITORING AGENCY NAME( S ) AND ADDRESS(ES) Office of Naval Research 875 N. Randolph St

The role of laser technology in materials processing and nondestructive testing in the 21st century

NASA Astrophysics Data System (ADS)

Sheinberg, B. M.

Some of the potential applications of laser technology in the 21st century are explored, and the proposed role of this technology in relation to materials processing, nondestructive testing, and quality control are discussed. Examples illustrating the implementation of this techology include the proposed construction of vehicles and platforms in near and deep space, and construction of underwater platforms. The direction in which today's technology should evolve to pursue the achievement of such goals is indicated. Included in the discussion is an evaluation of laser, robotics, and fiber optics technologies with respect to their ability to achieve a synergistic level of operation.

The effects of sour tea (Hibiscus sabdariffa) on hypertension in patients with type II diabetes.

PubMed

Mozaffari-Khosravi, H; Jalali-Khanabadi, B-A; Afkhami-Ardekani, M; Fatehi, F; Noori-Shadkam, M

2009-01-01

To compare the antihypertensive effectiveness of sour tea (ST; Hibiscus sabdariffa) with black tea (BT) infusion in diabetic patients, this double-blind randomized controlled trial was carried out. Sixty diabetic patients with mild hypertension, without taking antihypertensive or antihyperlipidaemic medicines, were recruited in the study. The patients were randomly allocated to the ST and BT groups and instructed to drink ST and BT infusions two times a day for 1 month. Their blood pressure (BP) was measured on days 0, 15 and 30 of the study. The mean of systolic BP (SBP) in the ST group decreased from 134.4+/-11.8 mm Hg at the beginning of the study to 112.7+/-5.7 mm Hg after 1 month (P-value <0.001), whereas this measure changed from 118.6+/-14.9 to 127.3+/-8.7 mm Hg (P-value=0.002) in the BT group during the same period. The intervention had no statistically significant effect on the mean of diastolic BP (DBP) in either the ST or BT group. The mean pulse pressure (PP) of the patients in the ST group decreased from 52.2+/-12.2 to 34.5+/-9.3 mm Hg (P-value <0.001) during the study, whereas in the BT group, it increased from 41.9+/-11.7 to 47.3+/-9.6 mm Hg (P-value=0.01). In conclusion, consuming ST infusion had positive effects on BP in type II diabetic patients with mild hypertension. This study supports the results of similar studies in which antihypertensive effects have been shown for ST.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rodrigues, Davi C.; Piattella, Oliver F.; Chauvineau, Bertrand, E-mail: davi.rodrigues@cosmo-ufes.org, E-mail: Bertrand.Chauvineau@oca.eu, E-mail: oliver.piattella@pq.cnpq.br

We show that Renormalization Group extensions of the Einstein-Hilbert action for large scale physics are not, in general, a particular case of standard Scalar-Tensor (ST) gravity. We present a new class of ST actions, in which the potential is not necessarily fixed at the action level, and show that this extended ST theory formally contains the Renormalization Group case. We also propose here a Renormalization Group scale setting identification that is explicitly covariant and valid for arbitrary relativistic fluids.

Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway.

PubMed

Robles, Ana I; Olsen, Karina Standahl; Tsui, Dana W T; Georgoulias, Vassilis; Creaney, Jenette; Dobra, Katalin; Vyberg, Mogens; Minato, Nagahiro; Anders, Robert A; Børresen-Dale, Anne-Lise; Zhou, Jianwei; Sætrom, Pål; Nielsen, Boye Schnack; Kirschner, Michaela B; Krokan, Hans E; Papadimitrakopoulou, Vassiliki; Tsamardinos, Ioannis; Røe, Oluf D

2016-10-19

The goal of biomarker research is to identify clinically valid markers. Despite decades of research there has been disappointingly few molecules or techniques that are in use today. The "1st International NTNU Symposium on Current and Future Clinical Biomarkers of Cancer: Innovation and Implementation", was held June 16th and 17th 2016, at the Knowledge Center of the St. Olavs Hospital in Trondheim, Norway, under the auspices of the Norwegian University of Science and Technology (NTNU) and the HUNT biobank and research center. The Symposium attracted approximately 100 attendees and invited speakers from 12 countries and 4 continents. In this Symposium original research and overviews on diagnostic, predictive and prognostic cancer biomarkers in serum, plasma, urine, pleural fluid and tumor, circulating tumor cells and bioinformatics as well as how to implement biomarkers in clinical trials were presented. Senior researchers and young investigators presented, reviewed and vividly discussed important new developments in the field of clinical biomarkers of cancer, with the goal of accelerating biomarker research and implementation. The excerpts of this symposium aim to give a cutting-edge overview and insight on some highly important aspects of clinical cancer biomarkers to-date to connect molecular innovation with clinical implementation to eventually improve patient care.

Effectiveness of Systems Engineering (SE) Tailored for the Science & Technology (S&T) Environment: Improvement of USAF Airdrop Accuracy

DTIC Science & Technology

2011-10-27

public release; distribution is unlimited  Dr. Keith Bowman, AFRL, Precision Airdrop ( PAD ) Program Manager  Ms. Carol Ventresca, SynGenics Corporation...Presentation Outline  Entrance Criteria for PAD  Integrated Product Team (IPT)  S&T SE Process Steps  Initial Project S&T Development Strategy...Entrance Criteria for PAD  Integrated Product Team (IPT)  S&T SE Process Steps  Initial Project S&T Development Strategy  User Understanding of

Space Technology 7 : Micropropulsion and Mass Distribution

NASA Technical Reports Server (NTRS)

Carnaub, A.; Dunn, C.; Ziemer, J,; Hruby, V.; Spence, D.; Demmons, N.; Roy, T.; McCormick, R.; Gasaska, C.; Young, J.;

Advances in Sprint Acceleration Profiling for Field-Based Team-Sport Athletes: Utility, Reliability, Validity and Limitations.

PubMed

Simperingham, Kim D; Cronin, John B; Ross, Angus

2016-11-01

Advanced testing technologies enable insight into the kinematic and kinetic determinants of sprint acceleration performance, which is particularly important for field-based team-sport athletes. Establishing the reliability and validity of the data, particularly from the acceleration phase, is important for determining the utility of the respective technologies. The aim of this systematic review was to explain the utility, reliability, validity and limitations of (1) radar and laser technology, and (2) non-motorised treadmill (NMT) and torque treadmill (TT) technology for providing kinematic and kinetic measures of sprint acceleration performance. A comprehensive search of the CINAHL Plus, MEDLINE (EBSCO), PubMed, SPORTDiscus, and Web of Science databases was conducted using search terms that included radar, laser, non-motorised treadmill, torque treadmill, sprint, acceleration, kinetic, kinematic, force, and power. Studies examining the kinematics or kinetics of short (≤10 s), maximal-effort sprint acceleration in adults or children, which included an assessment of reliability or validity of the advanced technologies of interest, were included in this systematic review. Absolute reliability, relative reliability and validity data were extracted from the selected articles and tabulated. The level of acceptance of reliability was a coefficient of variation (CV) ≤10 % and an intraclass correlation coefficient (ICC) or correlation coefficient (r) ≥0.70. A total of 34 studies met the inclusion criteria and were included in the qualitative analysis. Generally acceptable validity (r = 0.87-0.99; absolute bias 3-7 %), intraday reliability (CV ≤9.5 %; ICC/r ≥0.84) and interday reliability (ICC ≥0.72) were reported for data from radar and laser. However, low intraday reliability was reported for the theoretical maximum horizontal force (ICC 0.64) within adolescent athletes, and low validity was reported for velocity during the initial 5 m of a sprint acceleration (bias up to 0.41 m/s) measured with a laser device. Acceptable reliability of results from NMT and TT was only ensured when testing protocols involved sufficient familiarisation, a high sampling rate (≥200 Hz), a 'blocked' start position, and the analysis of discrete steps rather than arbitrary time periods. Sprinting times and speeds were 20-28 % slower on a TT, 28-67 % slower on an NMT, and only 9-64 % of the variance in overground measurements of speed and time (≤30 m) was explained by results from an NMT. There have been no reports to date of criterion validity of kinetic measures of sprint acceleration performance on NMT andTT, and only limited results regarding acceptable concurrent validity of radar-derived kinetic data. Radar, laser, NMT and TT technologies can be used to reliably measure sprint acceleration performance and to provide insight into the determinants of sprinting speed. However, further research is required to establish the validity of the kinetic measurements made with NMT and TT. Radar and laser technology may not be suitable for measuring the first few steps of a sprint acceleration.

The Challenge To Be Relevant in the 21st Century: Abstracts and Full Text Documents of Papers and Demos Given at the [International Association of Technological University Libraries] IATUL Conference (Pretoria, South Africa, June 1-5, 1998), Volume 18.

ERIC Educational Resources Information Center

International Association of Technological Univ. Libraries, Gothenburg (Sweden).

This proceedings of the 1998 conference of the International Association of Technological University Libraries (IATUL) contains the full text of the following papers: "A Library Ready for 21st Century Services: The Case of the University of Science and Technology (UST) Library, Kumasi, Ghana" (Helena Rebecca Asamoah-Hassan);…

[Media for 21st century--towards human communication media].

PubMed

Harashima, H

2000-05-01

Today, with the approach of the 21st century, attention is focused on multi-media communications combining computer, visual and audio technologies. This article discusses the communication media target and the technological problems constituting the nucleus of multi-media. The communication media is becoming an environment from which no one can escape. Since the media has such a great power, what is needed now is not to predict the future technologies, but to estimate the future world and take to responsibility for future environments.

Assessing the Assistive Technology Act of 1998. Hearing before the Subcommittee on 21st Century Competitiveness of the Committee on Education and the Workforce. House of Representatives, One Hundred Seventh Congress, Second Session (March 21, 2002).

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. House Committee on Education and the Workforce.

This document presents the transcript of a hearing before the House Subcommittee on 21st Century Competitiveness concerning the implementation of the Assistive Technology Act of 1998 and the future role of the federal government in this area. Highlights of the testimony include state assistive technology projects, provision of low-interest loans…

Quantity of sucrose alters the tissue pattern and time course of insulin resistance in young rats.

PubMed

Pagliassotti, M J; Prach, P A

1995-09-01

To determine the effects of the amount of sucrose in the diet on insulin-stimulated glucose metabolism, euglycemic hyperinsulinemic clamps were performed on male Wistar rats after one of the following dietary treatments (n = 6-8/treatment): 1) high-starch diet (68% of total energy) for 8 wk (ST8), 16 wk (ST16), or 30 wk (ST30); 2) high-sucrose diet (68% of total energy) for 8 wk (SU8), 16 wk (SU16), or 30 wk (SU30); or 3) low-sucrose diet (18% of total energy) for 8 wk (SUL8), 16 wk (SUL16), or 30 wk (SUL30). Body weights were similar in starch- and sucrose-fed rats at 8 wk (502 +/- 9 g), 16 wk (563 +/- 10 g), and 30 wk (607 +/- 26 g). The glucose infusion rate (mumol.g-1.min-1) required to maintain similar glycemia during clamps was 73.1 +/- 8.8 in ST8, 29.7 +/- 4.9 in SU8 (P < 0.05 vs. ST8 and SUL8), and 76.4 +/- 8.2 in SUL8; 69.9 +/- 8.1 in ST16, 35.1 +/- 5.1 in SU16 (P < 0.05 vs. ST16 and SUL16), and 63.2 +/- 6.5 in SUL16; and 65.4 +/- 7.7 in ST30, 26.0 +/- 5.3 (P < 0.05 vs. ST30), and 36.3 +/- 6.0 in SUL30 (P < 0.05 vs. ST30). Impaired suppression of hepatic glucose production accounted for 43, 39, and 34% of the decrease in the glucose infusion rate in SU8 compared with ST8, SU16 compared with ST16, and SU30 compared with ST30, respectively, but 78% in SUL30 compared with ST30. These results suggest that both high- and low-sucrose diets can produce insulin resistance in young rats.(ABSTRACT TRUNCATED AT 250 WORDS)

Enabling the Future: Linking Science and Technology to Societal Goals. A Report.

ERIC Educational Resources Information Center

Carnegie Commission on Science, Technology, and Government, New York, NY.

This report seeks ways to improve the knowledge, understanding, and information available to the federal government on the long-term nature of the science and technology (S&T) enterprise as it relates to societal goals. The recommendations focus on a few key issues: improving the national capacity to define and revise long-term S&T goals; linking…

The Role of ICT in the Teaching and Learning of History in the 21st Century

ERIC Educational Resources Information Center

Adesote, S. A; Fatoki, O. R

2013-01-01

This paper examines the role of Information and Communication Technology in the Teaching and Learning of History in the Senior Secondary School in the 21st century. The new Information and communication technologies of internet and multimedia which have led to positive impact in the field of education in most developed countries are still at…

"Educating 21st Century Students: A Close-Up Look at a Successful Career and Technical Center"

ERIC Educational Resources Information Center

Fala, John; Kathryn, Strouse; Tully, Christopher; Viviano, Thomas

2012-01-01

Through this paper we try to convey the necessity to provide the workforce with a labor force that is academically and technologically ready to meet the 21st century global demands. We feel this is accomplished by providing the students at MBIT [Middle Bucks Institute of Technology] with industry-standard equipment, academic and technology…

Technology Enhanced Formative Assessment for 21st Century Learning

ERIC Educational Resources Information Center

Spector, J. Michael; Ifenthaler, Dirk; Sampson, Demetrios; Yang, Lan; Mukama, Evode; Warusavitarana, Amali; Dona, Kulari Lokuge; Eichhorn, Koos; Fluck, Andrew; Huang, Ronghuai; Bridges, Susan; Lu, Jiingyan; Ren, Youqun; Gui, Xiaoqing; Deneen, Christopher C.; San Diego, Jonathan; Gibson, David C.

2016-01-01

This paper is based on the deliberations of the Assessment Working Group at EDUsummIT 2015 in Bangkok, Thailand. All of the members of Thematic Working Group 5 (TWG5) have contributed to this synthesis of potentials, concerns and issues with regard to the role of technology in assessment as, for and of learning in the 21st century. The group…

Information Technology for Good (IT4G): Merging Information Technology with Social Responsibility

ERIC Educational Resources Information Center

Saulnier, Bruce

2013-01-01

A case is made for a new approach to higher education in the 21st century, an approach in which the traditional majors are extended beyond their usual boundaries by applying one's education to address the public good. The LEAP initiative and the Learning Paradigm College are advanced as exemplars of effective 21st century educational practices,…

The Impact of One-to-One Technology Programs on Student Acquisition of 21st-Century Skills

ERIC Educational Resources Information Center

McDowell, Joshua A.

2017-01-01

This qualitative phenomenological study was designed to gain an in-depth understanding of the perceptions of secondary public-school teachers of the impact that one-to-one technology programs have on student acquisition of 21st-century skills. 20 certified public school teachers were targeted using a purposeful sampling method, in 4 public school…

Fostering Students' 21st Century Skills through Project Oriented Problem Based Learning (POPBL) in Integrated STEM Education Program

ERIC Educational Resources Information Center

Wan Husin, Wan Nor Fadzilah; Mohamad Arsad, Nurazidawati; Othman, Oziah; Halim, Lilia; Rasul, Mohamad Sattar; Osman, Kamisah; Iksan, Zanaton

2016-01-01

Students nowadays need to be equipped with twenty first century skills in order to ensure their competitiveness in this era of globalization, especially in the science and technology sector. Therefore, this study aimed to identify the changes of 21st century skills among students after participating in an integrated Science, Technology,…

Enterprise Architecture Tradespace Analysis

DTIC Science & Technology

2014-02-21

EXECUTIVE SUMMARY The Department of Defense (DoD)’s Science & Technology (S&T) priority for Engineered Resilient Systems (ERS) calls for...Science & Technology (S&T) priority for Engineered Resilient Systems (ERS) calls for adaptable designs with diverse systems models that can easily be...Department of Defense [Holland, 2012]. Some explicit goals are: • Establish baseline resiliency of current capabilities • More complete and robust

Designing and Implementing a Science, Technology and Innovation Policy in a Developing Country: Recent Experience from Nigeria

ERIC Educational Resources Information Center

Siyanbola, W. O.; Olaopa, O. R.; Hassan, O. M.

2013-01-01

The authors examine how a realistic science, technology and innovation policy can be formulated to enhance the development and management of a nation's physical and human assets and to accelerate socio-economic development through focused S&T engagement. The paper traces the evolution of S&T policies in Nigeria, particularly between 1986…

Looking for Patterns in OfStEd Judgements about Primary Pupil Achievement in Design and Technology

ERIC Educational Resources Information Center

Cross, Alan

2006-01-01

Respective English governments have placed considerable faith, political weight and not inconsiderable sums of money in a system of school inspection organised and led by the Office for Standards in Education (OfStEd). This article considers a so-called foundation subject, design and technology, and the extent to which we might meaningfully use…

Space Technology-5 Lithium-Ion Battery Design, Qualification and Integration and Testing

NASA Technical Reports Server (NTRS)

Rao, Gopalakishna M.; Stewart, Karen; Ameen, Syed; Banfield, Peter K.

2005-01-01

This document is a viewgraph presentation that reviews the Lithium Ion Battery for the Space Technology-5 (ST-5) mission. Included in the document is a review of the ST-5 Mission, a review of the battery requirements, a description of the battery and the battery materials. The testing and the integration and qualification data is reviewed.

Decreased H3K9ac level of StAR mediated testicular dysplasia induced by prenatal dexamethasone exposure in male offspring rats.

PubMed

Liu, Min; Chen, Biao; Pei, Linguo; Zhang, Qi; Zou, Yunfei; Xiao, Hao; Zhou, Jin; Chen, Liaobin; Wang, Hui

2018-06-11

Prenatal dexamethasone exposure (PDE) could induce testicular developmental toxicity in adults. The present study aims to confirm its intrauterine origination, and to explore its potential intrauterine programming mechanism. The pregnant rats were respectively injected subcutaneously with 0.2 and 0.8 mg/kg⋅d dexamethasone during gestational days (GD) 9 to 20. The testes and serum of offspring rats were collected on GD20 and postnatal week (PW) 12. In vivo, PDE significantly induced the abnormal testicular morphology in offspring from GD20 to PW12. Moreover, the serum and intratesticular testosterone levels and the expression of testicular steroidogenic acute regulatory protein (StAR) were reduced by PDE. The expression levels of glucocorticoid receptor (GR) and histone deacetylase 7 (HDAC7) were increased in fetal testes. Furthermore, the histone 3 lysine 9 acetylation (H3K9ac) level in the StAR promoter was decreased by PDE from GD20 to PW12. In vitro, mouse Leydig tumour cell line (MLTC-1) cells were treated with dexamethasone (20, 100 and 500 nM), and the testosterone production and StAR expression were reduced. Moreover, dexamethasone increased the expression of HDAC7 by activating GR, which decreased the H3K9ac level in the StAR promoter. Taken together, PDE caused testicular dysplasia before and after birth in male offspring rats, and its mechanism was related to the low-expressional programming of StAR mediated by decreasing H3K9ac level. Copyright © 2018. Published by Elsevier B.V.

Prognostic Value of Strain by Tissue Tracking Cardiac Magnetic Resonance After ST-Segment Elevation Myocardial Infarction.

PubMed

Gavara, Jose; Rodriguez-Palomares, Jose F; Valente, Filipa; Monmeneu, Jose V; Lopez-Lereu, Maria P; Bonanad, Clara; Ferreira-Gonzalez, Ignacio; Garcia Del Blanco, Bruno; Rodriguez-Garcia, Julian; Mutuberria, Maria; de Dios, Elena; Rios-Navarro, Cesar; Perez-Sole, Nerea; Racugno, Paolo; Paya, Ana; Minana, Gema; Canoves, Joaquim; Pellicer, Mauricio; Lopez-Fornas, Francisco J; Barrabes, Jose; Evangelista, Arturo; Nunez, Julio; Chorro, Francisco J; Garcia-Dorado, David; Bodi, Vicente

2017-12-08

The aim of this study was to evaluate the prognostic value of strain as assessed by tissue tracking (TT) cardiac magnetic resonance (CMR) soon after ST-segment elevation myocardial infarction (STEMI). The prognostic value of myocardial strain as assessed post-STEMI by TT-CMR is unknown. The authors studied the prognostic value of TT-CMR in 323 patients who underwent CMR 1 week post-STEMI. Global (average of peak segmental values [%]) and segmental (number of altered segments) longitudinal (LS), circumferential, and radial strain were assessed using TT-CMR. Global and segmental strain cutoff values were derived from 32 control patients. CMR-derived left ventricular ejection fraction, microvascular obstruction, and infarct size were determined. Results were validated in an external cohort of 190 STEMI patients. During a median follow-up of 1,085 days, 54 first major adverse cardiac events (MACE), which included 10 cardiac deaths, 25 readmissions for heart failure, and 19 readmissions for reinfarction were documented. MACE was associated with more severe abnormalities in all strain indexes (p < 0.001), although only global LS was an independent predictor (p < 0.001). The MACE rate was higher in patients with a global LS of ≥-11% (22% vs. 9%; p = 0.001). After adjustment for baseline and CMR variables, global LS (hazard ratio [HR]: 1.21; 95% confidence interval [CI]: 1.11 to 1.32; p < 0.001) was associated with MACE. In the external validation cohort, a global LS ≥-11% was seen in a higher proportion of patients with MACE (34% vs. 9%; p < 0.001). Global LS predicted MACE after adjustment for baseline and CMR variables (HR: 1.18; 95% CI: 1.04 to 1.33; p = 0.008). The addition of global LS to the multivariate models, including baseline and CMR variables, did not significantly improve the categorical net reclassification improvement index in either the study group (-0.015; p = 0.7) or in the external validation cohort (-0.019; p = 0.9). TT-CMR provided prognostic information soon after STEMI. However, it did not substantially improve risk reclassification beyond traditional CMR indexes. Copyright © 2017 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Reliability and Concurrent Validity of the Narrow Path Walking Test in Persons With Multiple Sclerosis.

PubMed

Rosenblum, Uri; Melzer, Itshak

2017-01-01

About 90% of people with multiple sclerosis (PwMS) have gait instability and 50% fall. Reliable and clinically feasible methods of gait instability assessment are needed. The study investigated the reliability and validity of the Narrow Path Walking Test (NPWT) under single-task (ST) and dual-task (DT) conditions for PwMS. Thirty PwMS performed the NPWT on 2 different occasions, a week apart. Number of Steps, Trial Time, Trial Velocity, Step Length, Number of Step Errors, Number of Cognitive Task Errors, and Number of Balance Losses were measured. Intraclass correlation coefficients (ICC2,1) were calculated from the average values of NPWT parameters. Absolute reliability was quantified from standard error of measurement (SEM) and smallest real difference (SRD). Concurrent validity of NPWT with Functional Reach Test, Four Square Step Test (FSST), 12-item Multiple Sclerosis Walking Scale (MSWS-12), and 2 Minute Walking Test (2MWT) was determined using partial correlations. Intraclass correlation coefficients (ICCs) for most NPWT parameters during ST and DT ranged from 0.46-0.94 and 0.55-0.95, respectively. The highest relative reliability was found for Number of Step Errors (ICC = 0.94 and 0.93, for ST and DT, respectively) and Trial Velocity (ICC = 0.83 and 0.86, for ST and DT, respectively). Absolute reliability was high for Number of Step Errors in ST (SEM % = 19.53%) and DT (SEM % = 18.14%) and low for Trial Velocity in ST (SEM % = 6.88%) and DT (SEM % = 7.29%). Significant correlations for Number of Step Errors and Trial Velocity were found with FSST, MSWS-12, and 2MWT. In persons with PwMS performing the NPWT, Number of Step Errors and Trial Velocity were highly reliable parameters. Based on correlations with other measures of gait instability, Number of Step Errors was the most valid parameter of dynamic balance under the conditions of our test.Video Abstract available for more insights from the authors (see Supplemental Digital Content 1, available at: http://links.lww.com/JNPT/A159).

A new 4-variable formula to differentiate normal variant ST segment elevation in V2-V4 (early repolarization) from subtle left anterior descending coronary occlusion - Adding QRS amplitude of V2 improves the model.

PubMed

Driver, Brian E; Khalil, Ayesha; Henry, Timothy; Kazmi, Faraz; Adil, Amina; Smith, Stephen W

Precordial normal variant ST elevation (NV-STE), previously often called "early repolarization," may be difficult to differentiate from subtle ischemic STE due to left anterior descending (LAD) occlusion. We previously derived and validated a logistic regression formula that was far superior to STE alone for differentiating the two entities on the ECG. The tool uses R-wave amplitude in lead V4 (RAV4), ST elevation at 60 ms after the J-point in lead V3 (STE60V3) and the computerized Bazett-corrected QT interval (QTc-B). The 3-variable formula is: 1.196 x STE60V3 + 0.059 × QTc-B - 0.326 × RAV4 with a value ≥23.4 likely to be acute myocardial infarction (AMI). Adding QRS voltage in V2 (QRSV2) would improve the accuracy of the formula. 355 consecutive cases of proven LAD occlusion were reviewed, and those that were obvious ST elevation myocardial infarction were excluded. Exclusion was based on one straight or convex ST segment in V2-V6, 1 millimeter of summed inferior ST depression, any anterior ST depression, Q-waves, "terminal QRS distortion," or any ST elevation >5 mm. The NV-STE group comprised emergency department patients with chest pain who ruled out for AMI by serial troponins, had a cardiologist ECG read of "NV-STE," and had at least 1 mm of STE in V2 and V3. R-wave amplitude in lead V4 (RAV4), ST elevation at 60 ms after the J-point in lead V3 (STE60V3) and the computerized Bazett-corrected QT interval (QTc-B) had previously been measured in all ECGs; physicians blinded to outcome then measured QRSV2 in all ECGs. A 4-variable formula was derived to more accurately classify LAD occlusion vs. NV-STE and optimize area under the curve (AUC) and compared with the previous 3-variable formula. There were 143 subtle LAD occlusions and 171 NV-STE. A low QRSV2 added diagnostic utility. The derived 4-variable formula is: 0.052*QTc-B - 0.151*QRSV2 - 0.268*RV4 + 1.062*STE60V3. The 3-variable formula had an AUC of 0.9538 vs. 0.9686 for the 4-variable formula (p = 0.0092). At the same specificity as the 3-variable formula [90.6%, at which cutpoint (≥23.4), 123 of 143 MI were correctly classified for 86% sensitivity], the sensitivity of the new formula at cutpoint ≥17.75 is 90.2%, with 129/143 correctly classified MI, identifying an additional 6 cases. The cutpoint with the highest accuracy (92.0%) was at a cutoff value ≥18.2, with 88.8% sensitivity, 94.7% specificity, and a positive and negative likelihood ratio of 16.9 (95% CI: 8.9-32) and 0.12 (95% CI: 0.07-0.19). At this cutpoint, it correctly classified an additional 11 cases (289 of 315, vs. 278 of 315): 127/143 for MI (an additional 4 cases) and 162/171 for NV-STE (an additional 7 cases). On the ECG, a 4-variable formula was derived which adds QRSV2; it differentiates subtle LAD occlusion from NV-STE better than the 3-variable formula. At a value ≥18.2, the formula (0.052*QTc-B - 0.151*QRSV2 - 0.268*RV4 + 1.062*STE60V3) was very accurate, sensitive, and specific, with excellent positive and negative likelihood ratios. This formula needs to be validated. Copyright © 2017 Elsevier Inc. All rights reserved.

Strontium

USGS Publications Warehouse

Angulo, M.A.

2010-01-01

In 2009, U.S. apparent consumption of strontium (contained in celestite and manufactured strontium compounds) increased to 16 kt (17,600 st) from 10.6 kt (11,700 st) in 2008, an increase of 52 percent. This increase was attributed primarily to an increase in imported celestite. Gross weight of imports totaled 25.3 kt (27,900 st), of which 91 percent came from Mexico. Imports in 2009 were 18 percent more than in 2008. Exports of strontium compounds in 2009 decreased 15 percent to 9.3 kt (10,250 st) from 10.9 kt (12,000 st) in 2008. In 2009, the U.S. Customs value of imported strontium carbonate was 65 cents/kg (29 cents/lb); for strontium nitrate, the unit value was $ 1/kg (45 cents/lb). The unit value of imported celestite, all of which was from Mexico, was about $47/t ($43/st).

IVUS Findings in Late and Very Late Stent Thrombosis. A Comparison Between Bare-metal and Drug-eluting Stents.

PubMed

Fuentes, Lara; Gómez-Lara, Josep; Salvatella, Neus; Gonzalo, Nieves; Hernández-Hernández, Felipe; Fernández-Nofrerias, Eduard; Sánchez-Recalde, Ángel; Alfonso, Fernando; Romaguera, Rafael; Ferreiro, José Luis; Roura, Gerard; Teruel, Luis; Gracida, Montserrat; Marcano, Ana Lucrecia; Gómez-Hospital, Joan-Antoni; Cequier, Ángel

2018-05-01

Stent thrombosis (ST) is a life-threatening complication after stent implantation. Intravascular ultrasound is able to discern most causes of ST. The aim of this study was to compare intravascular ultrasound findings between bare-metal stents (BMS) and drug-eluting stents (DES) in patients with late (31 days to 1 year) or very late ST (> 1 year). Of 250 consecutive patients with late or very late ST in 7 Spanish institutions, 114 patients (45.5% BMS and 54.5% DES) were imaged with intravascular ultrasound. Off-line intravascular ultrasound analysis was performed to assess malapposition, underexpansion, and neoatherosclerosis. The median time from stent implantation to ST was 4.0 years with BMS and 3.4 years with DES (P = .04). Isolated malapposition was similarly observed in both groups (36.5% vs 46.8%; P = .18) but was numerically lower with BMS (26.6% vs 48.0%; P = .07) in patients with very late ST. Isolated underexpansion was similarly observed in both groups (13.5% vs 11.3%; P = .47). Isolated neoatherosclerosis occurred only in patients with very late ST and was more prevalent with BMS (22.9%) than with DES (6.0%); P = .02. At 2.9 years' follow-up, there were 0% and 6.9% cardiac deaths, respectively (P = .06) and recurrent ST occurred in 4.0% and 5.2% of patients, respectively (P = .60). Malapposition was the most common finding in patients with late and very late ST and is more prevalent with DES in very late ST. In contrast, neoatherosclerosis was exclusively observed in patients with very late ST and mainly with BMS. Copyright © 2017 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.

77 FR 419 - Drawbridge Operation Regulation; St. Johns River, Jacksonville, FL

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-05

... Operation Regulation; St. Johns River, Jacksonville, FL AGENCY: Coast Guard, DHS. ACTION: Notice of... bridge across the St. Johns River, mile 24.9, in Jacksonville, Florida. The regulation is set forth in 33... automated railroad bridge over the St. Johns River in Jacksonville, Florida. This temporary deviation will...

77 FR 24978 - Eastern States: Filing of Plats of Survey; Mississippi

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-26

... surveyed are: St. Stephens Meridian, Mississippi T. 9 N., R. 17 W. The supplemental plat of Section 1, in Township 9 North, Range 17 West, of the St. Stephens Meridian, in the State Mississippi, and was accepted...

75 FR 14429 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-25

... COMMODITY FUTURES TRADING COMMISSION Sunshine Act Meeting Time and Date: 11 a.m., Friday, April 9, 2010. Place: 1155 21st St., NW., Washington, DC, 9th Floor Commission Conference Room. Status: Closed...-23-10; 11:15 am] BILLING CODE 6351-01-P ...

75 FR 38086 - Sunshine Act Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-01

... COMMODITY FUTURES TRADING COMMISSION Sunshine Act Meetings Time and Date: 11 a.m., Friday, July 9, 2010. Place: 1155 21st St., NW., Washington, DC, 9th Floor Commission Conference Room. Status: Closed...-29-10; 4:15 pm] BILLING CODE 6351-01-P ...

Literature, Logic, and Language

ERIC Educational Resources Information Center

Dakin, Mary Ellen

2010-01-01

The nation's leaders say that a 21st-century education must restore the competitive edge and prepare students for success in the marketplace; they affirm that the material wealth of a 21st-century nation is built upon the intellectual capital of science, technology, engineering, and math (STEM). But teachers need to remember this: A 21st-century…

Preparing Students for the Future--21st Century Skills

ERIC Educational Resources Information Center

Velez, Alejandra

2012-01-01

The 21st century economy is driven by information and communication technologies (ICT). This change has made innovation, manufacturing and production of products and services, rather than manufacturing of material goods, the driving force of economies of leading countries (Wagner, 2008). Due to this shift, today's 21st century society and…

Rebuilding the LMS for the 21st Century

ERIC Educational Resources Information Center

Demski, Jennifer

2012-01-01

Finally--12 years into the 21st century--higher ed classrooms are turning into incubators for the kind of learning environment that curriculum and instructional technology experts have advocated for years. Yet a key question remains: Can legacy learning management systems (LMSs) be dragged into the 21st century as part of this new educational…

Twenty-First Century Learning: Communities, Interaction and Ubiquitous Computing

ERIC Educational Resources Information Center

Leh, Amy S.C.; Kouba, Barbara; Davis, Dirk

2005-01-01

Advanced technology makes 21st century learning, communities and interactions unique and leads people to an era of ubiquitous computing. The purpose of this article is to contribute to the discussion of learning in the 21st century. The paper will review literature on learning community, community learning, interaction, 21st century learning and…

Smart Social Networking: 21st Century Teaching and Learning Skills

ERIC Educational Resources Information Center

Boholano, Helen B.

2017-01-01

Education in the 21st century highlights globalization and internationalization. Pre-service teachers in the 21st century are technology savvy. To effectively engage and teach generation Z students, preservice teachers will help the educational system meet this requirement. The educational systems must be outfitted with a prerequisite of ICT…

Validation of In utero Tractography of Human Fetal Commissural and Internal Capsule Fibers with Histological Structure Tensor Analysis

PubMed Central

Mitter, Christian; Jakab, András; Brugger, Peter C.; Ricken, Gerda; Gruber, Gerlinde M.; Bettelheim, Dieter; Scharrer, Anke; Langs, Georg; Hainfellner, Johannes A.; Prayer, Daniela; Kasprian, Gregor

2015-01-01

Diffusion tensor imaging (DTI) and tractography offer the unique possibility to visualize the developing white matter macroanatomy of the human fetal brain in vivo and in utero and are currently under investigation for their potential use in the diagnosis of developmental pathologies of the human central nervous system. However, in order to establish in utero DTI as a clinical imaging tool, an independent comparison between macroscopic imaging and microscopic histology data in the same subject is needed. The present study aimed to cross-validate normal as well as abnormal in utero tractography results of commissural and internal capsule fibers in human fetal brains using postmortem histological structure tensor (ST) analysis. In utero tractography findings from two structurally unremarkable and five abnormal fetal brains were compared to the results of postmortem ST analysis applied to digitalized whole hemisphere sections of the same subjects. An approach to perform ST-based deterministic tractography in histological sections was implemented to overcome limitations in correlating in utero tractography to postmortem histology data. ST analysis and histology-based tractography of fetal brain sections enabled the direct assessment of the anisotropic organization and main fiber orientation of fetal telencephalic layers on a micro- and macroscopic scale, and validated in utero tractography results of corpus callosum and internal capsule fiber tracts. Cross-validation of abnormal in utero tractography results could be achieved in four subjects with agenesis of the corpus callosum (ACC) and in two cases with malformations of internal capsule fibers. In addition, potential limitations of current DTI-based in utero tractography could be demonstrated in several brain regions. Combining the three-dimensional nature of DTI-based in utero tractography with the microscopic resolution provided by histological ST analysis may ultimately facilitate a more complete morphologic characterization of axon guidance disorders at prenatal stages of human brain development. PMID:26732460

Correlates of strength training in older rural African American and Caucasian women.

PubMed

Bopp, Melissa; Wilcox, Sara; Oberrecht, Larissa; Kammermann, Sandra; McElmurray, Charles T

2004-01-01

This study examined factors influencing strength training (ST) in two convenience samples of older rural women. Focus group (FG) participants were 23 Caucasian and 16 African American women aged 67.5 +/- 9.2 years. Survey participants were 60 Caucasian and 42 African American women, aged 70.59 +/- 9.21 years. FG participants answered questions about the risks, benefits, and barriers to ST. Survey participants completed measures of demographics, physical activity (including ST), depression and stress, decisional balance for exercise (DBE), barriers to PA, and social support (SS). Regression modeling examined correlates of ST. FG participants identified physical health gains and improved appearance as ST benefits. African American women also included mental health benefits and "feeling good". Both Caucasian and African American groups named physical health problems as risks of ST. Caucasian women identified time constraints, lack of ST knowledge, physical health problems, lack of exercise facilities, and the cost of ST as barriers. African American women cited being "too tired", physical health problems, lack of support, and other family and work responsibilities. The linear regression model explained 23.2% of the variance in hours per week of ST; DBE and family SS were independent positive correlates. This study identified correlates to participation in ST in older rural women and provides a basis for developing ST interventions in this population.

Technology-Based Assessments for 21st Century Skills: Theoretical and Practical Implications from Modern Research. Current Perspectives on Cognition, Learning and Instruction

ERIC Educational Resources Information Center

Mayrath, Michael C., Ed.; Clarke-Midura, Jody, Ed.; Robinson, Daniel H., Ed.; Schraw, Gregory, Ed.

2012-01-01

Creative problem solving, collaboration, and technology fluency are core skills requisite of any nation's workforce that strives to be competitive in the 21st Century. Teaching these types of skills is an economic imperative, and assessment is a fundamental component of any pedagogical program. Yet, measurement of these skills is complex due to…

Design, System, Value: The Role of Problem-Solving and Critical Thinking Capabilities in Technology Education, as Perceived by Teachers

ERIC Educational Resources Information Center

Schooner, Patrick; Nordlöf, Charlotta; Klasander, Claes; Hallström, Jonas

2017-01-01

The Organisation for Economic Co-operation and Development (OECD, 2013) defines its views on necessary skills for 21st century citizenship and life-long learning, advocating a generic skillset of literacy, numeracy, and problem-solving in technology-rich environments. Other sources also include critical thinking as a vital 21st Century skill.…

Investigating the Quality of Project-Based Science and Technology Learning Environments in Elementary School: A Critical Review of Instruments

ERIC Educational Resources Information Center

Thys, Miranda; Verschaffel, Lieven; Van Dooren, Wim; Laevers, Ferre

2016-01-01

This paper provides a systematic review of instruments that have the potential to measure the quality of project-based science and technology (S&T) learning environments in elementary school. To this end, a comprehensive literature search was undertaken for the large field of S&T learning environments. We conducted a horizontal bottom-up…

18 Minutes and 11 Seconds Online: Exploring the Cogntive Processes of 12 Good Writers Writing on the Internet

ERIC Educational Resources Information Center

Zheng, Jinjie

2013-01-01

New technologies and Internet resources are becoming more and more integral to 21st century writing. To write well in the 21st century requires the coordination of new technologies, new skills, and new information. The central challenge to coordinate these new elements of contemporary writing is the deictic influence they have on writing.…

Development and validation of a building design waste reduction model.

PubMed

Llatas, C; Osmani, M

2016-10-01

Reduction in construction waste is a pressing need in many countries. The design of building elements is considered a pivotal process to achieve waste reduction at source, which enables an informed prediction of their wastage reduction levels. However the lack of quantitative methods linking design strategies to waste reduction hinders designing out waste practice in building projects. Therefore, this paper addresses this knowledge gap through the design and validation of a Building Design Waste Reduction Strategies (Waste ReSt) model that aims to investigate the relationships between design variables and their impact on onsite waste reduction. The Waste ReSt model was validated in a real-world case study involving 20 residential buildings in Spain. The validation process comprises three stages. Firstly, design waste causes were analyzed. Secondly, design strategies were applied leading to several alternative low waste building elements. Finally, their potential source reduction levels were quantified and discussed within the context of the literature. The Waste ReSt model could serve as an instrumental tool to simulate designing out strategies in building projects. The knowledge provided by the model could help project stakeholders to better understand the correlation between the design process and waste sources and subsequently implement design practices for low-waste buildings. Copyright © 2016 Elsevier Ltd. All rights reserved.

M Protein Gene (emm Type) Analysis of Group A Beta-Hemolytic Streptococci from Ethiopia Reveals Unique Patterns

PubMed Central

Tewodros, Wezenet; Kronvall, Göran

2005-01-01

The genetic diversity of group A streptococcal (GAS) isolates obtained in 1990 from Ethiopian children with various streptococcal diseases was studied by using emm gene sequence analysis. A total of 217 GAS isolates were included: 155 and 62 isolates from throat and skin, respectively. A total of 78 different emm/st types were detected among the 217 isolates. Of these, 166 (76.5%) belonged to 52 validated reference emm types, 26 (11.9%) belonged to 16 already recognized sequence types (st types) and 25 (11.5%) belonged to 10 undocumented new sequence types. Resistance to tetracycline (148 of 217) was not correlated to emm type. Isolation rate of the classical rheumatogenic and nephritogenic strains was low from cases of acute rheumatic fever (ARF) and acute glomerulonephritis (AGN), respectively. Instead, the recently discovered st types were overrepresented among isolates from patients with ARF (3 of 7) and AGN (9 of 16) (P < 0.01) compared to isolates from subjects with tonsillitis and from healthy carriers (10 of 57 and 16 of 90, respectively). In contrast to rheumatogenic strains from the temperate regions, more than half of the isolates from ARF (four of seven) carried the genetic marker for skin preference, emm pattern D, although most of them (six of seven) were isolated from throat. Of 57 tonsillitis-associated isolates, 16 (28%) belonged to emm pattern D compared to <1% in temperate regions. As in other reports emm patterns A to C were strongly associated with throat, whereas emm pattern D did not correlate to skin. This first large-scale emm typing report from Africa has demonstrated a heterogeneous GAS population and contrasting nature of GAS epidemiology in the region. PMID:16145079

Molecular characterization of resistance, virulence and clonality in vancomycin-resistant Enterococcus faecium and Enterococcus faecalis: A hospital-based study in Beijing, China.

PubMed

Yang, Jing-xian; Li, Tong; Ning, Yong-zhong; Shao, Dong-hua; Liu, Jing; Wang, Shu-qin; Liang, Guo-wei

2015-07-01

The incidence of vancomycin-resistant enterococcus (VRE) in China is increasing, the molecular epidemiology of VRE in China is only partly known. This study was conducted to assess the molecular characterization of resistance, virulence and clonality of 69 vancomycin-resistant Enterococcus faecium (VREfm) and seven vancomycin-resistant Enterococcus faecalis (VREfs) isolates obtained from a Chinese hospital between July 2011 and July 2013. The glycopeptide resistance genes (VanA and VanB) were screened by multiplex PCR. The presence of five putative virulence genes (esp, gelE, asa1, hyl and cylA) were evaluated by another multiplex PCR. Multilocus sequence typing (MLST) scheme was used to assess the clonality. All 76 VRE isolates exhibited VanA phenotype and harbored VanA gene. Esp was the only gene detected both in VREfm and VREfs strains, accounting for 89.9% and 42.9%, respectively. The hyl gene was merely positive in 27.5% of VREfm strains. MLST analysis demonstrated three STs (ST6, ST4 and ST470) in VREfs and twelve STs (ST78, ST571, ST17, ST564, ST389, ST18, ST547, ST341, ST414, ST343, ST262 and ST203) in VREfm, which were all designated as CC17 by eBURST algorithm. An outbreak of VREfm belonging to ST571 was found to happen within the neurology ward in this hospital. To our knowledge, this is the first report of ST6 (CC2) VREfs strains in China and the first outbreak report of VREfm strains belonging to ST571 around the world. Our data could offer important information for understanding the molecular features of VRE in China. Copyright © 2015 Elsevier B.V. All rights reserved.

BEaST: brain extraction based on nonlocal segmentation technique.

PubMed

Eskildsen, Simon F; Coupé, Pierrick; Fonov, Vladimir; Manjón, José V; Leung, Kelvin K; Guizard, Nicolas; Wassef, Shafik N; Østergaard, Lasse Riis; Collins, D Louis

2012-02-01

Brain extraction is an important step in the analysis of brain images. The variability in brain morphology and the difference in intensity characteristics due to imaging sequences make the development of a general purpose brain extraction algorithm challenging. To address this issue, we propose a new robust method (BEaST) dedicated to produce consistent and accurate brain extraction. This method is based on nonlocal segmentation embedded in a multi-resolution framework. A library of 80 priors is semi-automatically constructed from the NIH-sponsored MRI study of normal brain development, the International Consortium for Brain Mapping, and the Alzheimer's Disease Neuroimaging Initiative databases. In testing, a mean Dice similarity coefficient of 0.9834±0.0053 was obtained when performing leave-one-out cross validation selecting only 20 priors from the library. Validation using the online Segmentation Validation Engine resulted in a top ranking position with a mean Dice coefficient of 0.9781±0.0047. Robustness of BEaST is demonstrated on all baseline ADNI data, resulting in a very low failure rate. The segmentation accuracy of the method is better than two widely used publicly available methods and recent state-of-the-art hybrid approaches. BEaST provides results comparable to a recent label fusion approach, while being 40 times faster and requiring a much smaller library of priors. Copyright © 2011 Elsevier Inc. All rights reserved.

Equilibrium states of homogeneous sheared compressible turbulence

NASA Astrophysics Data System (ADS)

Riahi, M.; Lili, T.

2011-06-01

Equilibrium states of homogeneous compressible turbulence subjected to rapid shear is studied using rapid distortion theory (RDT). The purpose of this study is to determine the numerical solutions of unsteady linearized equations governing double correlations spectra evolution. In this work, RDT code developed by authors solves these equations for compressible homogeneous shear flows. Numerical integration of these equations is carried out using a second-order simple and accurate scheme. The two Mach numbers relevant to homogeneous shear flow are the turbulent Mach number Mt, given by the root mean square turbulent velocity fluctuations divided by the speed of sound, and the gradient Mach number Mg which is the mean shear rate times the transverse integral scale of the turbulence divided by the speed of sound. Validation of this code is performed by comparing RDT results with direct numerical simulation (DNS) of [A. Simone, G.N. Coleman, and C. Cambon, Fluid Mech. 330, 307 (1997)] and [S. Sarkar, J. Fluid Mech. 282, 163 (1995)] for various values of initial gradient Mach number Mg0. It was found that RDT is valid for small values of the non-dimensional times St (St < 3.5). It is important to note that RDT is also valid for large values of St (St > 10) in particular for large values of Mg0. This essential feature justifies the resort to RDT in order to determine equilibrium states in the compressible regime.

Space Technology 5 Observations of Auroral Field-Aligned Currents

NASA Technical Reports Server (NTRS)

Slavin, James

2008-01-01

During its three month long technology validation mission, Space Technology 5 (ST-5) returned high quality multi-point measurements of the near-Earth magnetic field. Its three micro-satellites were launched into a 300 x 4500 km, dawn - dusk, sun synchronous orbit (inclination = 105.60) orbit with a period of 138 min by a Pegasus launch vehicle on March 22, 2006. The spacecraft were maintained in a "pearls on a sting" constellation with controlled spacings ranging from just over 5000 km down to under 50 km. The individual micro-satellites were 48 cm tall octagons with diameters of 50 cm. They were spin-stabilized at approximately 20 rpm at deployment and slowly spun-down to about 15 rpm by the end of the mission. Each spacecraft carried a miniature tri-axial fluxgate magnetometer (MAG) provided by the University of California at Los Angeles mounted at the end of a ultra-low mass 72 cm boom. These data allow, for the first time, the separation of temporal and spatial variations in field-aligned current (FAC) perturbations measured in low-Earth orbit on time scales of 10 sec to 10 min. The constellation measurements are used to directly determine field-aligned current sheet motion, thickness. and current density. Two multi-point methods for the inference of FAC current density that have not previously been possible in low-Earth orbit are demonstrated: 1) the -standard method." based upon s/c velocity, but corrected for FAC current sheet motion. and 2) the "gradiometer method" which uses simultaneous magnetic field measurements at two points with known separation. Future studies will apply these methods to the entire ST-5 data sct and expand to include horizontal ionospheric currents. ULF waves and geomagnetic field gradient analyses.

33 CFR 117.651 - St. Joseph River.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false St. Joseph River. 117.651 Section... DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Michigan § 117.651 St. Joseph River. The draws of the US33 (Blossomland) bridge, mile 0.9, and the BL-94 (Bicentennial) bridge, mile 1.3, both at St. Joseph...

75 FR 6407 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-09

..., 10000058 MASSACHUSETTS Bristol County Ingraham, Robert C., School, 80 Rivet St., New Bedford, 10000056 Middlesex County Groton High School, 145 Main St., Groton, 10000057 NEW YORK Putnam County West Point... St., Chariton, 10000054 Story County Roosevelt School, 921 9th St., Ames, 10000055 MAINE York County...

Lab meets real life: A laboratory assessment of spontaneous thought and its ecological validity

PubMed Central

Welz, Annett; Reinhard, Iris; Alpers, Georg W.

2017-01-01

People’s minds frequently wander towards self-generated thoughts, which are unrelated to external stimuli or demands. These phenomena, referred to as “spontaneous thought” (ST) and “mind wandering” (MW), have previously been linked with both costs and benefits. Current assessments of ST and MW have predominantly been conducted in the laboratory, whereas studies on the ecological validity of such lab-related constructs and their interrelations are rare. The current study examined the stability of ST dimensions assessed in the lab and their predictive value with respect to MW, repetitive negative thought (uncontrollable rumination, RUM), and affect in daily life. Forty-three university students were assessed with the Amsterdam Resting State Questionnaire (2nd version) to assess ten ST dimensions during the resting state in two laboratory sessions, which were separated by five days of electronic ambulatory assessment (AA). During AA, individuals indicated the intensity of MW and RUM, as well as of positive and negative affect in daily life ten times a day. ST dimensions measured in the lab were moderately stable across one week. Five out of ten ST lab dimensions were predicted by mental health-related symptoms or by dispositional cognitive traits. Hierarchical linear models revealed that a number of ST lab dimensions predicted cognitive and affective states in daily life. Mediation analyses showed that RUM, but not MW per se, accounted for the relationship between specific ST lab dimensions and mood in daily life. By using a simple resting state task, we could demonstrate that a number of lab dimensions of spontaneous thought are moderately stable, are predicted by mental health symptoms and cognitive traits, and show plausible associations with categories of self-generated thought and mood in daily life. PMID:28910351

Engine technology challenges for a 21st Century High-Speed Civil Transport

NASA Technical Reports Server (NTRS)

Shaw, Robert J.; Gilkey, Samuel; Hines, Richard

1993-01-01

Ongoing NASA-funded studies by Boeing, McDonnell-Douglas, General Electric, and Pratt & Whitney indicate that an opportunity exists for a 21st Century High-Speed Civil Transport (HSCT) to become a major part of the international air transportation system. However, before industry will consider an HSCT product launch and an investment estimated to be over $15 billion for design and certification, major technology advances must be made. An overview of the propulsion-specific technology advances that must be in hand before an HSCT product launch could be considered is presented.

77 FR 64108 - Sunshine Act Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-18

... COMMODITY FUTURES TRADING COMMISSION Sunshine Act Meetings AGENCY HOLDING THE MEETING: Commodity Futures Trading Commission. TIME AND DATE: 10:00 a.m., Friday November 9, 2012. PLACE: 1155 21st St. NW., Washington, DC, 9th Floor Commission Conference Room. STATUS: Closed. MATTERS TO BE CONSIDERED: Surveillance...

Cross-Cultural Adaptation, Reliability and Validity Study of the Persian Version of the Clinical COPD Questionnaire.

PubMed

Hasanpour, Neda; Attarbashi Moghadam, Behrouz; Sami, Ramin; Tavakol, Kamran

2016-08-01

The clinical COPD questionnaire (CCQ) has been developed to measure the health status of COPD patients. The aim of this study was to translate CCQ into the Persian language and assess the validity and reliability of the translated version. We used a forward-backward procedure to translate the questionnaire. In a cross-sectional study 100 COPD patients and 50 healthy subjects over 40 years old were selected to assess the reliability and construct validity of the instrument. The face and content validity were used for the questionnaire validity. Validity was examined in a population of patients with COPD, using the Persian validated version of the St George's Respiratory Questionnaire (PSGRQ). In order to assess the questionnaire's reliability, the Intraclass correlation coefficient (ICC) and Cronbach's alpha were calculated. Test-retest reliability was tested by re-administering the Persian version of the CCQ (PCCQ) after 1 week. Test-retest carry out of data demonstrates that the PCCQ has excellent reliability (ICC for all 3 domains were higher than 0.9). Internal consistency was found by Cronbach's alpha to be 0.96, 0.94, 0.97, and 0.98 for the symptom, mental state, functional state and total scores respectively. In addition, the correlation between the components of PCCQ and PSGRQ showed satisfactory construct validity. Analyzing the data from healthy subjects and patients divulged that the PCCQ has acceptable discriminant validity. In general, the PCCQ had satisfactory reliability and validity for assessing health-related quality of life status of Iranian COPD patients.

Motives of 21st-Century-Skills Group Questioned

ERIC Educational Resources Information Center

Sawchuk, Stephen

2009-01-01

Depending on whom one asks, "21st-century skills" can mean different things: technology literacy, the ability to analyze and apply knowledge, a knack for working effectively with colleagues in teams. In what is probably its most visible form for educators, though, the term refers to the work of the Partnership for 21st Century Skills, the Tucson,…

21st Century-Based Soft Skills: Spotlight on Non-Cognitive Skills in a Cognitive-Laden Dentistry Program

ERIC Educational Resources Information Center

Quieng, Marjorie C.; Lim, Pearly P.; Lucas, Maria Rita D.

2015-01-01

Teaching and learning in the 21st century aims to produce students proficient in content knowledge, specific abilities, literacy, numeracy, and technology uses. From these 21st century skills, soft skills were delineated from these learning outcomes; and defined as intra- and interpersonal skills vital for personal development, social…

Intersubject variability and intrasubject reproducibility of 12-lead ECG metrics: Implications for human verification.

PubMed

Jekova, Irena; Krasteva, Vessela; Leber, Remo; Schmid, Ramun; Twerenbold, Raphael; Müller, Christian; Reichlin, Tobias; Abächerli, Roger

Electrocardiogram (ECG) biometrics is an advanced technology, not yet covered by guidelines on criteria, features and leads for maximal authentication accuracy. This study aims to define the minimal set of morphological metrics in 12-lead ECG by optimization towards high reliability and security, and validation in a person verification model across a large population. A standard 12-lead resting ECG database from 574 non-cardiac patients with two remote recordings (>1year apart) was used. A commercial ECG analysis module (Schiller AG) measured 202 morphological features, including lead-specific amplitudes, durations, ST-metrics, and axes. Coefficient of variation (CV, intersubject variability) and percent-mean-absolute-difference (PMAD, intrasubject reproducibility) defined the optimization (PMAD/CV→min) and restriction (CV<30%) criteria for selection of the most stable and distinctive features. Linear discriminant analysis (LDA) validated the non-redundant feature set for person verification. Maximal LDA verification sensitivity (85.3%) and specificity (86.4%) were validated for 11 optimal features: R-amplitude (I,II,V1,V2,V3,V5), S-amplitude (V1,V2), Tnegative-amplitude (aVR), and R-duration (aVF,V1). Copyright © 2016 Elsevier Inc. All rights reserved.

Where’s Cap Haitien? Validating the Principles of Peace Operations

DTIC Science & Technology

1999-12-17

health risks to the military with exposure to disease, specifically malaria and dengue fever. Former members of the FAD’H posed potential security...Co (TACON) C/65 EN (L) (DS) (-) 3/58 MP CO (DS) 1/A/125SIGBN(+) DPSE 22 TPT 221 TPT 223 CATPT-2/416CABN SEC/351 AG CO (POSTAL) (DS) (-) MIST...Barbuda, the Bahamas, Barbados, Belize , Dominica, Grenada, Guyana, Jamaica, St. Kitts and Nevis, St. Lucia, St Vincent and the Grenadines, and Trinidad

46 CFR 44.01-12 - Voyage limits; special service.

Code of Federal Regulations, 2010 CFR

2010-10-01

... valid for manned vessels during the hurricane season, i.e., July 1st to November 15th, both dates... the special service load line is not valid for manned vessels during the hurricane season, i.e., July...

46 CFR 44.01-12 - Voyage limits; special service.

Code of Federal Regulations, 2013 CFR

2013-10-01

... valid for manned vessels during the hurricane season, i.e., July 1st to November 15th, both dates... the special service load line is not valid for manned vessels during the hurricane season, i.e., July...

46 CFR 44.01-12 - Voyage limits; special service.

Code of Federal Regulations, 2014 CFR

2014-10-01

... valid for manned vessels during the hurricane season, i.e., July 1st to November 15th, both dates... the special service load line is not valid for manned vessels during the hurricane season, i.e., July...

46 CFR 44.01-12 - Voyage limits; special service.

Code of Federal Regulations, 2012 CFR

2012-10-01

... valid for manned vessels during the hurricane season, i.e., July 1st to November 15th, both dates... the special service load line is not valid for manned vessels during the hurricane season, i.e., July...

46 CFR 44.01-12 - Voyage limits; special service.

Code of Federal Regulations, 2011 CFR

2011-10-01

... valid for manned vessels during the hurricane season, i.e., July 1st to November 15th, both dates... the special service load line is not valid for manned vessels during the hurricane season, i.e., July...

High Resolution Airborne InSAR DEM of Bagley Ice Valley, South-central Alaska: Geodetic Validation with Airborne Laser Altimeter Data

NASA Astrophysics Data System (ADS)

Muskett, R. R.; Lingle, C. S.; Echelmeyer, K. A.; Valentine, V. B.; Elsberg, D.

2001-12-01

Bagley Ice Valley, in the St. Elias and Chugach Mountains of south-central Alaska, is an integral part of the largest connected glacierized terrain on the North American continent. From the flow divide between Mt. Logan and Mt. St. Elias, Bagley Ice Valley flows west-northwest for some 90 km down a slope of less than 1o, at widths up to 15 km, to a saddle-gap where it turns south-west to become Bering Glacier. During 4-13 September 2000, an airborne survey of Bagley Ice Valley was performed by Intermap Technologies, Inc., using their Star-3i X-band SAR interferometer. The resulting digital elevation model (DEM) covers an area of 3243 km2. The DEM elevations are orthometric heights, in meters above the EGM96 geoid. The horizontal locations of the 10-m postings are with respect to the WGS84 ellipsoid. On 26 August 2000, 9 to 18 days prior to the Intermap Star-3i survey, a small-aircraft laser altimeter profile was acquired along the central flow line for validation. The laser altimeter data consists of elevations above the WGS84 ellipsoid and orthometric heights above GEOID99-Alaska. Assessment of the accuracy of the Intermap Star-3i DEM was made by comparison of both the DEM orthometric heights and elevations above the WGS84 ellipsoid with the laser altimeter data. Comparison of the orthometric heights showed an average difference of 5.4 +/- 1.0 m (DEM surface higher). Comparison of elevations above the WGS84 ellipsoid showed an average difference of -0.77 +/- 0.93 m (DEM surface lower). This indicates that the X-band Star-3i interferometer was penetrating the glacier surface by an expected small amount. The WGS84 comparison is well within the 3 m RMS accuracy quoted for GT-3 DEM products. Snow accumulation may have occurred, however, on Bagley Ice Valley between 26 August and 4-13 September 2000. This will be estimated using a mass balance model and used to correct the altimeter-derived surface heights. The new DEM of Bagley Ice Valley will provide a reference surface of high accuracy for glaciological and geodetic research using ICEsat and small-aircraft laser altimeter profiling of this glaciologically important region of south-central Alaska.

Interest, Motivation and Attitude towards Science and Technology at K-12 Levels: A Systematic Review of 12?Years of Educational Research

ERIC Educational Resources Information Center

Potvin, Patrice; Hasni, Abdelkrim

2014-01-01

The relationship that exists between students and science and technology (S&T) is a complex and important one. If it is positive, then social, economic and environmental consequences are to be expected. Yet, many problems of interest/motivation/attitude (I/M/A) towards S&T have been recorded. A lot of research has been conducted on this…

The development of learning competency and skills for the 21st century to integrate "TPCK" of world life with local environment in students grade 11

NASA Astrophysics Data System (ADS)

Jedaman, Pornchai; Kinboon, Nittayaporn; Suksup, Chareon; Kinboon, Wutcharapong

2018-01-01

The teaching strategies of append were the technological pedagogical content knowledge; TPCK. This description knowledge in a content to corresponds of a effective teaching. This article aims to address the relevance of; 1) the learning competency and skills for the 21st Century to integrate "TPCK" of a world life with local environment in the students grade 11, 2) the effective achievement of the learning competency and skills to integrate "TPCK" of world life with local environment in the students grade 11 were the passing score of a percentage 80 upwards (EI.), and 3) the attitudes for learning activities in the students grade 11. The study employed both quantitative and qualitative approaches for 9teachers of third schools were the participatory action research (PAR) in collecting data including a instructional, a testing, and a questionnaire surveywith 33 students grade 11 of Phuwiengwittayakom school. The participants werecluster random sampling. The data analysis of descriptive statistical, percentage, mean average, standard deviation. The findings in the study were to learning competency and skills for the 21st Century to integrate "TPCK" of a world life with local environment on TK, PK, CK, and TCK at a excellent levels (X¯ = 3.62, 3.57, 3.54, 3.51) respectively, and PCK, TPK,TPCK at a good levels (X¯ = 3.36, 3.23, 3.17) respectively. The effective achievement of the learning competency and skills to integrate "TPCK" of world life with local environment in 30 students grade 11 were the passing score (EI.) of a percentage at 90.91. The attitudes for learning activities in the students grade 11 at a high levels (X¯ =3.29). In addition of the students grade 11 to understanding of the importance were a local learning resources including the value integrating technology of the knowledge technology and to choose the right were create of an effective information.

ARC-1969-A-20485

NASA Image and Video Library

1955-06-22

Grumman F9F-6 (Bu. No. 128138) Cougar airplane. EVALUATION OF CARRIER APPROACH TECHNIQUES Boundary Layer Control, STOL, and V/STOL Note: Used in publication in Flight Research at Ames; 57 Years of Development and Validation of Aeronautical Technology NASA SP-1998-3300 fig. 101

Flying the ST-5 Constellation with "Plug and Play" Autonomy Components and the GMSEC Bus

NASA Technical Reports Server (NTRS)

Shendock, Bob; Witt, Ken; Stanley, Jason; Mandl, Dan; Coyle, Steve

2006-01-01

The Space Technology 5 (ST5) Project, part of NASA's New Millennium Program, will consist of a constellation of three micro-satellites. This viewgraph document presents the components that will allow it to operate in an autonomous mode. The ST-5 constellation will use the GSFC Mission Services Evolution Center (GMSEC) architecture to enable cost effective model based operations. The ST-5 mission will demonstrate several principles of self managing software components.

Influence of age, sex, and strength training on human muscle gene expression determined by microarray

PubMed Central

ROTH, STEPHEN M.; FERRELL, ROBERT E.; PETERS, DAVID G.; METTER, E. JEFFREY; HURLEY, BEN F.; ROGERS, MARC A.

2010-01-01

The purpose of this study was to determine the influence of age, sex, and strength training (ST) on large-scale gene expression patterns in vastus lateralis muscle biopsies using high-density cDNA microarrays and quantitative PCR. Muscle samples from sedentary young (20–30 yr) and older (65–75 yr) men and women (5 per group) were obtained before and after a 9-wk unilateral heavy resistance ST program. RNA was hybridized to cDNA filter microarrays representing ~4,000 known human genes and comparisons were made among arrays to determine differential gene expression as a result of age and sex differences, and/or response to ST. Sex had the strongest influence on muscle gene expression, with differential expression (>1.7-fold) observed for ~200 genes between men and women (~75% with higher expression in men). Age contributed to differential expression as well, as ~50 genes were identified as differentially expressed (>1.7-fold) in relation to age, representing structural, metabolic, and regulatory gene classes. Sixty-nine genes were identified as being differentially expressed (>1.7-fold) in all groups in response to ST, and the majority of these were downregulated. Quantitative PCR was employed to validate expression levels for caldesmon, SWI/SNF (BAF60b), and four-and-a-half LIM domains 1. These significant differences suggest that in the analysis of skeletal muscle gene expression issues of sex, age, and habitual physical activity must be addressed, with sex being the most critical variable. PMID:12209020

9. IMAGE OF THE EAST ELEVATION OF THE BRIDGE SHOWING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. IMAGE OF THE EAST ELEVATION OF THE BRIDGE SHOWING THE CONCRETE OPEN SPANDRELS, MISSING BALUSTRADES AND THE LAMP STANDARDS. - County Line Bridge, Spanning St. Joseph River at State Route 219, 0.6 mile south of U.S. Route 20, Osceola, St. Joseph County, IN

75 FR 57457 - Sunshine Act Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-21

... COMMODITY FUTURES TRADING COMMISSION Sunshine Act Meetings TIME AND DATE: 11 a.m., Friday, October 22, 2010. PLACE: 1155 21st St., NW., Washington, DC, 9th Floor Commission Conference Room. STATUS.... [FR Doc. 2010-23649 Filed 9-17-10; 4:15 pm] BILLING CODE 6351-01-P ...

75 FR 57457 - Sunshine Act Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-21

... COMMODITY FUTURES TRADING COMMISSION Sunshine Act Meetings TIME AND DATE: 11 a.m., Friday, October 8, 2010. PLACE: 1155 21st St., NW., Washington, DC, 9th Floor Commission Conference Room. STATUS.... [FR Doc. 2010-23647 Filed 9-17-10; 4:15 pm] BILLING CODE 6351-01-P ...

75 FR 57457 - Sunshine Act Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-21

... COMMODITY FUTURES TRADING COMMISSION Sunshine Act Meetings TIME AND DATE: 11 a.m., Friday October 15, 2010. PLACE: 1155 21st St., NW., Washington, DC, 9th Floor Commission Conference Room. STATUS.... [FR Doc. 2010-23648 Filed 9-17-10; 4:15 pm] BILLING CODE 6351-01-P ...

75 FR 57457 - Sunshine Act Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-21

... COMMODITY FUTURES TRADING COMMISSION Sunshine Act Meetings Time and Date: 11 a.m., Friday, October 1, 2010. Place: 1155 21st St., NW., Washington, DC, 9th Floor Commission Conference Room. Status.... [FR Doc. 2010-23645 Filed 9-17-10; 4:15 pm] BILLING CODE 6351-01-P ...

75 FR 57457 - Sunshine Act Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-21

... COMMODITY FUTURES TRADING COMMISSION Sunshine Act Meetings TIME AND DATE: 11 a.m., Friday, October 29, 2010. PLACE: 1155 21st St., NW., Washington, DC, 9th Floor Commission Conference Room. STATUS... Commission. [FR Doc. 2010-23650 Filed 9-17-10; 4:15 pm] BILLING CODE 6351-01-P ...

76 FR 72179 - Sunshine Act Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-22

... COMMODITY FUTURES TRADING COMMISSION Sunshine Act Meetings TIME AND DATE: 10 a.m., Friday, December 9, 2011. PLACE: 1155 21st St., NW., Washington, DC, 9th Floor Commission Conference Room. STATUS: Closed. MATTERS TO BE CONSIDERED: Surveillance and Enforcement Matters. In the event that the times or...

76 FR 53670 - Sunshine Act Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-29

... COMMODITY FUTURES TRADING COMMISSION Sunshine Act Meetings TIME AND DATE: 10 a.m., Friday, September 9, 2011. PLACE: 1155 21st St., NW., Washington, DC, 9th Floor Commission Conference Room. STATUS: Closed. MATTERS TO BE CONSIDERED: Surveillance and Enforcement Matters. In the event that the times or...

An Alternate, Egg-Free Radiolabeled Meal Formulation for Gastric-Emptying Scintigraphy.

PubMed

Garrigue, Philippe; Bodin-Hullin, Aurore; Gonzalez, Sandra; Sala, Quentin; Guillet, Benjamin

2017-07-01

Tc-radiolabeled scrambled eggs (SEs) are most often used as the ingested solid phase for gastric-emptying scintigraphy, leading egg-reluctant patients to avoid the examination. We formulated and validated 2 egg-free alternate meals, in the absence of any commercialized formulation: chocolate mug cake (MC) and scrambled tofu (ST). Six healthy volunteers underwent gastric-emptying scintigraphy after ingesting Tc-radiolabeled MC, ST, or SE. Gastric retention indexes did not change significantly between formulations (% of overtime variation to SE: MC 7.75% ± 7.1%, ST 7.17% ± 5.8%; P = 0.6618, not statistically significant), suggesting MC and ST as interesting egg-free alternatives.

EDITORIAL: The 1st International Conference on Nanomanufacturing (NanoMan2008) The 1st International Conference on Nanomanufacturing (NanoMan2008)

NASA Astrophysics Data System (ADS)

Luo, Jack Jiqui; Fang, Fengzhou

2009-05-01

Nanomanufacturing is an emerging technology in the field of synthesis of nanomaterials, manufacture of nanodevices, nanosystems and the relevant characterization technologies, and will greatly impact our society and environment: speeding up scientific discovery, technological development, improving healthcare and living standards and slowing down the exhaustion of energy resources, to name but few. The 1st International Conference on Nanomanufacturing (NanoMan2008) was held on the 13-16 July 2008 in Singapore in conjunction with ThinFilm2008 (The 4th International Conference on Technological Advances of Thin Films & Surface Coatings). Approximately 140 delegates from all over the world have participated in the conference and presented their latest discoveries and technological developments. The main focuses of the conference were modern nanomanufacturing by laser machining, focused ion beam fabrication, nano/micro-molding/imprinting, nanomaterial synthesis and characterization, nanometrology and nano/microsystems fabrication and characterization. There was also great interest in applications of nanomanufacturing technologies in traditional areas such as free form machining, polishing and grinding with nano-scale precision and the smoothness of surfaces of objects, and applications in space exploration, military and medicine. This special issue is devoted to NanoMan2008 with a collection of 9 invited talks presented at the conference, covering all the topics of nanomanufacturing technology and development. These papers have been upgraded by the authors with new results and discoveries since the preparation of the conference manuscripts, hence presenting the latest developments. We would like to take this opportunity to thank all the delegates who attended the conference and made the conference successful, and to the authors who contributed papers to this special issue. Thanks also go to the conference committee for their efforts and devotion to the conference. We would like to express our sincere thanks to Dr Ian Forbes and the other members of editorial board of the Journal of Micromechanics and Microengineering of the Institute of Physics for their help and support in making this special section. The conference was a success. We found there is a great demand for continuation of the conference, and it has been agreed by the conference committee to hold the conference biannually from now on. The 2nd International Conference on Nanomanufacturing (NanoMan2010) is to be held in Tianjin, China in 2010. On behalf of the committee we would like to take this opportunity to welcome everybody to NanoMan2010.

76 FR 34649 - Foreign-Trade Zone 119-Minneapolis-St. Paul, MN; Application for Reorganization Under Alternative...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-14

...--Minneapolis-St. Paul, MN; Application for Reorganization Under Alternative Site Framework An application has... current zone project includes the following sites: Site 1 (3,002 acres)--located at the Minneapolis-St...); Site 9 (20 acres)--1700 Wynne Avenue, St. Paul (Ramsey County); and, Site 10 (236 acres)-- Bloomington...

Controller Design for the ST7 Disturbance Reduction System

NASA Technical Reports Server (NTRS)

Maghami, Peiman; Markley, F. Landis; Dennehey, Neil; Houghton, Martin B.; Folkner, William M.; Bauer, Frank (Technical Monitor)

2002-01-01

The Space Technology 7 experiment will perform an on-orbit system-level validation of two specific Disturbance Reduction System technologies: a gravitational reference sensor employing a free-floating test mass and a set of micro-Newton colloidal thrusters. The Disturbance Reduction System is designed to maintain a spacecraft's position with respect to the free-floating test mass to less than 10 nm/ square root of Hz, over the frequency range 10(exp -3) Hz to 10(exp -2) Hz. This paper presents the design and analysis of the coupled drag-free and attitude control system that closes the loop between the gravitational reference sensor and the micro-Newton thrusters while incorporating star tracker data at low frequencies. The effects of actuation and measurement noise and disturbances on the spacecraft and test masses are evaluated in a seven-degree-of-freedom planar model incorporating two translational and one rotational degrees of freedom for the spacecraft and two translational degrees of freedom for each test mass.

Design and Analysis of the ST7 Disturbance Reduction System (DRS) Spacecraft Controller

NASA Technical Reports Server (NTRS)

Maghami, P. G.; Markley, F. L.; Houghton, M. B.; Dennehy, C. J.

2003-01-01

The Space Technology 7 experiment will perform an on-orbit system-level validation of two specific Disturbance Reduction System technologies: a gravitational reference sensor employing a free-floating test mass and a set of micronewton colloidal thrusters. The Disturbance Reduction System is designed to maintain a spacecraft's position with respect to the free-floating test mass to less than 10 nm/square root of Hz, over the frequency range 10(exp -3) Hz to 10(exp -2) Hz. This paper presents the design and analysis of the coupled drag-free and attitude control system that closes the loop between the gravitational reference sensor and the micronewton thrusters while incorporating star tracker data at low frequencies. The effects of actuation and measurement noise and disturbances on the spacecraft and test masses are evaluated in a seven-degree-of-freedom planar model incorporating two translational and one rotational degrees of freedom for the spacecraft and two translational degrees of freedom for each test mass.

Educational implications for surgical telementoring: a current review with recommendations for future practice, policy, and research.

PubMed

Augestad, K M; Han, H; Paige, J; Ponsky, T; Schlachta, C M; Dunkin, B; Mellinger, J

2017-10-01

Surgical telementoring (ST) was introduced in the sixties, promoting videoconferencing to enhance surgical education across large distances. Widespread use of ST in the surgical community is lacking. Despite numerous surveys assessing ST, there remains a lack of high-level scientific evidence demonstrating its impact on mentorship and surgical education. Despite this, there is an ongoing paradigm shift involving remote presence technologies and their application to skill development and technique dissemination in the international surgical community. Factors facilitating this include improved access to ST technology, including ease of use and data transmission, and affordability. Several international research initiatives have commenced to strengthen the scientific foundation documenting the impact of ST in surgical education and performance. International experts on ST were invited to the SAGES Project Six Summit in August 2015. Two experts in surgical education prepared relevant questions for discussion and organized the meeting (JP and HH). The questions were open-ended, and the discussion continued until no new item appeared. The transcripts of interviews were recorded by a secretary from SAGES. In this paper, we present a summary of the work performed by the SAGES Project 6 Education Working Group. We summarize the existing evidence regarding education in ST, identify and detail conceptual educational frameworks that may be used during ST, and present a structured framework for an educational curriculum in ST. The educational impact and optimal curricular organization of ST programs are largely unexplored. We outline the critical components of a structured ST curriculum, including prerequisites, teaching modalities, and key curricular components. We also detail research strategies critical to its continued evolution as an educational tool, including randomized controlled trials, establishment of a quality registry, qualitative research, learning analytics, and development of a standardized taxonomy.

Measuring diet in the 21st century: use of new technologies.

PubMed

Cade, Janet E

2017-08-01

The advent of the internet and smartphone technology has allowed dietary assessment to reach the 21st century! The variety of foods available on the supermarket shelf is now greater than ever before. New approaches to measuring diet may help to reduce measurement error and advance our understanding of nutritional determinants of disease. This advance provides the potential to capture detailed dietary data on large numbers of individuals without the need for costly and time-consuming manual nutrition coding. This aim of the present paper is to review the need for new technologies to measure diet with an overview of tools available. The three main areas will be addressed: (1) development of web-based tools to measure diet; (2) use of smartphone apps to self-monitor diet; (3) improving the quality of dietary assessment through development of an online library of tools. A practical example of the development of a web-based tool to assess diet myfood24 (www.myfood24.org) will be given exploring its potential, limitations and challenges. The development of a new food composition database using back-of-pack information will be described. Smartphone apps used to measure diet with a focus on obesity will be reviewed. Many apps are unreliable in terms of tracking, and most are not evaluated. Accurate and consistent measurement of diet is needed for public health and epidemiology. The choice of the most appropriate dietary assessment method tends to rely on experience. The DIET@NET partnership has developed best practice guidelines for selection of dietary assessment tools, which aim to improve the quality, consistency and comparability of dietary data. These developments provide us with a step-change in our ability to reliably characterise food and nutrient intake in population studies. The need for high-quality, validated systems will be important to fully realise the benefits of new technologies.

Development of classification models to detect Salmonella Enteritidis and Salmonella Typhimurium found in poultry carcass rinses by visible-near infrared hyperspectral imaging

NASA Astrophysics Data System (ADS)

Seo, Young Wook; Yoon, Seung Chul; Park, Bosoon; Hinton, Arthur; Windham, William R.; Lawrence, Kurt C.

2013-05-01

Salmonella is a major cause of foodborne disease outbreaks resulting from the consumption of contaminated food products in the United States. This paper reports the development of a hyperspectral imaging technique for detecting and differentiating two of the most common Salmonella serotypes, Salmonella Enteritidis (SE) and Salmonella Typhimurium (ST), from background microflora that are often found in poultry carcass rinse. Presumptive positive screening of colonies with a traditional direct plating method is a labor intensive and time consuming task. Thus, this paper is concerned with the detection of differences in spectral characteristics among the pure SE, ST, and background microflora grown on brilliant green sulfa (BGS) and xylose lysine tergitol 4 (XLT4) agar media with a spread plating technique. Visible near-infrared hyperspectral imaging, providing the spectral and spatial information unique to each microorganism, was utilized to differentiate SE and ST from the background microflora. A total of 10 classification models, including five machine learning algorithms, each without and with principal component analysis (PCA), were validated and compared to find the best model in classification accuracy. The five machine learning (classification) algorithms used in this study were Mahalanobis distance (MD), k-nearest neighbor (kNN), linear discriminant analysis (LDA), quadratic discriminant analysis (QDA), and support vector machine (SVM). The average classification accuracy of all 10 models on a calibration (or training) set of the pure cultures on BGS agar plates was 98% (Kappa coefficient = 0.95) in determining the presence of SE and/or ST although it was difficult to differentiate between SE and ST. The average classification accuracy of all 10 models on a training set for ST detection on XLT4 agar was over 99% (Kappa coefficient = 0.99) although SE colonies on XLT4 agar were difficult to differentiate from background microflora. The average classification accuracy of all 10 models on a validation set of chicken carcass rinses spiked with SE or ST and incubated on BGS agar plates was 94.45% and 83.73%, without and with PCA for classification, respectively. The best performing classification model on the validation set was QDA without PCA by achieving the classification accuracy of 98.65% (Kappa coefficient=0.98). The overall best performing classification model regardless of using PCA was MD with the classification accuracy of 94.84% (Kappa coefficient=0.88) on the validation set.

Advanced Exploration Technologies: Micro and Nano Technologies Enabling Space Missions in the 21st Century

NASA Technical Reports Server (NTRS)

Krabach, Timothy

1998-01-01

Some of the many new and advanced exploration technologies which will enable space missions in the 21st century and specifically the Manned Mars Mission are explored in this presentation. Some of these are the system on a chip, the Computed-Tomography imaging Spectrometer, the digital camera on a chip, and other Micro Electro Mechanical Systems (MEMS) technology for space. Some of these MEMS are the silicon micromachined microgyroscope, a subliming solid micro-thruster, a micro-ion thruster, a silicon seismometer, a dewpoint microhygrometer, a micro laser doppler anemometer, and tunable diode laser (TDL) sensors. The advanced technology insertion is critical for NASA to decrease mass, volume, power and mission costs, and increase functionality, science potential and robustness.

Development of the Variable Emittance Thermal Suite for the Space Technology 5 Microsatellite

NASA Technical Reports Server (NTRS)

Douglas, Donya M.; Swanson, Theodore; Osiander, Robert; Champion, John; Darrin, Ann Garrison; Biter, William; Chandrasekhar, Prasanna; Obenschain, Arthur (Technical Monitor)

2001-01-01

The advent of very small satellites, such as nano and microsatellites, logically leads to a requirement for smaller thermal control subsystems. In addition, the thermal control needs of the smaller spacecraft/instrument may well be different from more traditional situations. For example, power for traditional heaters may be very limited or unavailable, mass allocations may be severely limited, and fleets of nano/microsatellites will require a generic thermal design as the cost of unique designs will be prohibitive. Some applications may require significantly increased power levels while others may require extremely low heat loss for extended periods. Small spacecraft will have low thermal capacitance thus subjecting them to large temperature swings when either the heat generation rate changes or the thermal sink temperature changes. This situation, combined with the need for tighter temperature control, will present a challenging situation during transient operation. The use of "off-the-shelf" commercial spacecraft buses for science instruments will also present challenges. Older thermal technology, such as heaters, thermostats, and heat pipes, will almost certainly not be sufficient to meet the requirements of these new spacecraft/instruments. They are generally too heavy, not scalable to very small sizes, and may consume inordinate amounts of power. Hence there is a strong driver to develop new technology to meet these emerging needs. Variable emittance coatings offer an exciting alternative to traditional control methodologies and are one of the technologies that will be flown on Space Technology 5, a mission of three microsatellites designed to validate "enabling" technologies. Several studies have identified variable emittance coatings as applicable to a wide range of spacecraft, and to potentially offer substantial savings in mass and/or power over traditional approaches. This paper discusses the development of the variable emittance thermal suite for ST-5. More specifically, it provides a description of and the infusion and validation plans for the variable emittance coatings.

Integration and Testing Challenges of Small Satellite Missions: Experiences from the Space Technology 5 Project

NASA Technical Reports Server (NTRS)

Sauerwein, Timothy A.; Gostomski, Tom

2007-01-01

The Space Technology 5(ST5) payload was successfully carried into orbit on an OSC Pegasus XL launch vehicle, which was carried aloft and dropped from the OSC Lockheed L-1011 from Vandenberg Air Force Base March 22,2006, at 9:03 am Eastern time, 6:03 am Pacific time. In order to reach the completion of the development and successful launch of ST 5, the systems integration and test(I&T) team determined that a different approach was required to meet the project requirements rather than the standard I&T approach used for single, room-sized satellites. The ST5 payload, part of NASA's New Millennium Program headquartered at JPL, consisted of three micro satellites (approximately 30 kg each) and the Pegasus Support Structure (PSS), the system that connected the spacecrafts to the launch vehicle and deployed the spacecrafts into orbit from the Pegasus XL launch vehicle. ST5 was a technology demonstration payload, intended to test six (6) new technologies for potential use for future space flights along with demonstrating the ability of small satellites to perform quality science. The main technology was a science grade magnetometer designed to take measurements of the earth's magnetic field. The three spacecraft were designed, integrated, and tested at NASA Goddard Space Flight Center with integration and environmental testing occurring in the Bldg. 7-1 0-15-29. The three spacecraft were integrated and tested by the same I&T team. The I&T Manager determined that there was insufficient time in the schedule to perform the three I&T spacecraft activities in series used standard approaches. The solution was for spacecraft #1 to undergo integration and test first, followed by spacecraft #2 and #3 simultaneously. This simultaneous integration was successful for several reasons. Each spacecraft had a Lead Test Conductor who planned and coordinated their spacecraft through its integration and test activities. One team of engineers and technicians executed the integration of all three spacecraft, learning and gaining knowledge and efficiency as spacecraft #1 integration and testing progressed. They became acutely familiar with the hardware, operation and processes for I&T, thus each team member had the experience and knowledge to safely execute I&T for spacecraft #2 and #3 together. The integration team was very versatile and each member could perform many different activities or work any spacecraft, when needed. Daily meetings between the three Lead TCs and technician team allowed the team to plan and implement activities efficiently. The three (3) spacecraft and PSS were successfully integrated and tested, shipped to the launch site, and ready for launch per the I&T schedule that was planned three years previously.

Assessing 21st Century Skills: A Guide to Evaluating Mastery and Authentic Learning

ERIC Educational Resources Information Center

Greenstein, Laura

2012-01-01

The Common Core State Standards clearly define the skills students need for success in college and the 21st century workplace. The question is, how can you measure student mastery of skills like creativity, problem solving, and use of technology? Laura Greenstein demonstrates how teachers can teach and assess 21st century skills using authentic…

21st Century Skills Development: Learning in Digital Communities--Technology and Collaboration

ERIC Educational Resources Information Center

Short, Barbara J.

2012-01-01

This study examines some aspects of student performance in the 21 st century skills of Information and Communication (ICT) Literacy and collaboration. In this project, extant data from the Assessment and Teaching for 21st Century Skills project (ATC21S) will be examined. ATC21S is a collaborative effort among educational agencies in six countries,…

Comparison of the QRS Complex, ST-Segment, and T-Wave Among Patients with Left Bundle Branch Block with and without Acute Myocardial Infarction.

PubMed

Dodd, Kenneth W; Elm, Kendra D; Smith, Stephen W

2016-07-01

The modified Sgarbossa criteria have been validated as a rule for diagnosis of acute coronary occlusion (ACO) in left bundle branch block (LBBB). However, no analysis has been done on differences in the QRS complex, T-wave, or ST-segment concordance of < 1 mm in the derivation or validation studies. Furthermore, there was no comparison of patients with acute myocardial infarction (AMI) but without ACO (i.e., non-ST-elevation myocardial infarction [non-STEMI]) to patients with ACO or without AMI (no MI). We compare findings involving the QRS amplitude, ST-segment morphology, ST-concordance < 1 mm, and T-waves in patients with LBBB with ACO, non-STEMI, and no MI. Retrospectively, emergency department patients were identified with LBBB and ischemic symptoms but no MI, with angiographically proven ACO, and with non-STEMI. ACO, non-STEMI, and no MI groups consisted of 33, 24, and 105 patients. The sum of the maximum deflection of the QRS amplitude across all leads (ΣQRS) was smaller in patients with ACO than those without ACO (101.5 mm vs. 132.5 mm; p < 0.0001) and a cutoff of ΣQRS < 90 mm was 92% specific. For ACO, non-concave ST-segment morphology was 91% specific, any ST concordance ≥ 1 mm was 95% specific, and any ST concordance ≥ 0.5 mm was 94% sensitive. For non-STEMI, terminal T-wave concordance, analogous to biphasic T-waves, was moderately sensitive at 79%. We found differences in QRS amplitude, ST-segment morphology, and T-waves between patients with LBBB and ACO, non-STEMI, and no MI. However, none of these criteria outperformed the modified Sgarbossa criteria for diagnosis of ACO in LBBB. Copyright © 2016 Elsevier Inc. All rights reserved.

Indian Ocean Validation,

DTIC Science & Technology

1987-09-01

S9 fd 30 2 D0i 0m10 20 802 AR. Oy ad n A o io in 3 0 3 7 ..n . . . w o w., , ... .. . . . . d ata m gaterng eie ws amdfe Lito sT-1 Omeg nav~igtion AE...signals propagated from each of N stations over paths of 2-10 length dl, d2, ... as shown in Figure 2.1. Station 2 Station N Station 1 D dl SUBJECT Figure...t2* = (d1* - d2*)/c + ( El - 62) t2* - t3* = (d2* - d3*)/c + ( E2 - E3) t*N 1 - t*N - ( d *N 1 - dN*)/c + ( N-1 EN) (6) 47he results obtained in

A Policy and Program for Invigorating Science and Technology for National Security

DTIC Science & Technology

2014-04-01

technical support – academia competes against industry often appearing as cheap labour but then without generating commercially viable or sustainable...have new technology approved too bureaucratic keeping SME’s out of the market DSTO provide greater transparency of S&T goals to enable industry to...national security S&T. In endeavouring to meet the Government’s desire to reduce red tape and cognisant of the tight financial environment, consideration

Department of Defense Research, Development, Test, and Evaluation (RDT and E): Appropriations Structure

DTIC Science & Technology

2016-12-13

Task Force on Defense Science and Technology Base for the 21st Century, June 1998. Appropriations Structure of Defense RDT&E Congressional Research...Technology Base for the 21st Century, June 1998. 22 Ibid, p. 45. Appropriations Structure of Defense RDT&E Congressional Research Service 18 Applied...funding streams. Among the many other factors that may affect the effectiveness of the performance of RDT&E are: organizational structures and

Gravity, Magnetic and Electromagnetic Gradiometry; Strategic technologies in the 21st century

NASA Astrophysics Data System (ADS)

Veryaskin, Alexey V.

2018-02-01

Gradiometry is a multidisciplinary area that combines theoretical and applied physics, ultra-low noise electronics, precision engineering, and advanced signal processing. Applications include the search for oil, gas, and mineral resources, GPS-free navigation, defence, space missions, and medical research. This book provides readers with a comprehensive introduction, history, potential applications, and current developments in relation to some of the most advanced technologies in the 21st Century.

NASA-UVA Light Aerospace Alloy and Structures Technology Program (LA2ST)

NASA Technical Reports Server (NTRS)

Scully, John R.; Shiflet, Gary J.; Stoner, Glenn E.; Wert, John A.

1996-01-01

The NASA-UVA Light Aerospace Alloy and Structures Technology (LA2ST) Program was initiated in 1986 and continues with a high level of activity. The objective of the LA2ST Program is to conduct interdisciplinary graduate student research on the performance of next generation, light-weight aerospace alloys, composites and thermal gradient structures in collaboration with NASA-Langley researchers. Specific technical objectives are presented for each research project. We generally aim to produce relevant data and basic understanding of material mechanical response, environmental/corrosion behavior, and microstructure; new monolithic and composite alloys; advanced processing methods; new solid and fluid mechanics analyses; measurement and modeling advances; and a pool of educated graduate students for aerospace technologies. Three research areas are being actively investigated, including: (1) Mechanical and environmental degradation mechanisms in advanced light metals, (2) Aerospace materials science, and (3) Mechanics of materials for light aerospace structures.

Epidemiological study of erythromycin-resistant Streptococcus pyogenes from Korea and Japan by emm genotyping and multilocus sequence typing.

PubMed

Takahashi, Takashi; Arai, Kazuaki; Lee, Dong Hyun; Koh, Eun Ha; Yoshida, Haruno; Yano, Hisakazu; Kaku, Mitsuo; Kim, Sunjoo

2016-01-01

We determined the epidemiological characteristics of erythromycin (EM)-resistant Streptococcus pyogenes (group A streptococci, GAS) strains isolated from Korea and Japan, using emm genotyping and multilocus sequence typing (MLST). Clinical isolates of GAS had been collected from 1992 to 2012 in Korea and from 2004 to 2009 in Japan. EM resistance was determined by the microdilution method, and resistance genotypes were assessed by PCR. The emm genotyping and MLST were performed by DNA sequencing. The emm genotypes and sequence types (STs) were concordant in 143 (85.1%) of 168 EM-resistant GAS strains from Korea. ST36/emm12 (35.1%), ST52/emm28 (22.6%), and ST49/emm75 (16.1%) were the most common types. Most of the ST36 (93.9%) and ST52 (95.8%) strains harbored erm(B), whereas strains ST49, ST42, and ST15 contained mef(A). The concordance between emm genotypes and STs was 41 (93.2%) among 44 EM-resistant GAS strains from Japan. ST36/emm12 (34.1%), ST49/emm75 (18.2%), and ST28/emm1 (15.9%) were the major types. ST36 isolates harbored either erm(B) (56.3%) or mef(A) (37.5%), whereas isolates ST28, ST49, and ST38 carried only mef(A). The proportion of erm(B) and mef(A) was 66.1% and 33.3% in Korea and 22.7% and 68.2% in Japan, respectively. The common STs in Korea and Japan were ST36 and ST49, whereas ST52 was present only in Korea and ST28 only in Japan. Genotype erm(B) was predominant in Korea, whereas mef(A) was frequent in Japan. There were differences between Korea and Japan regarding the frequencies of emm genotypes, STs, and EM resistance genes among the EM-resistant GAS.

Validation of a Climate-Data Record of the "Clear-Kky" Surface Temperature of the Greenland Ice Sheet

NASA Technical Reports Server (NTRS)

Hall, Dorothy K.; Box, Jason E.; Koenig, Lora S.; DiGirolamo, Nicolo E.; Comiso, Josefino C.; Shuman, Christopher A.

2011-01-01

Surface temperatures on the Greenland Ice Sheet have been studied on the ground, using automatic weather station (AWS) data from the Greenland-Climate Network (GC-Net), and from analysis of satellite sensor data. Using Advanced Very High Frequency Radiometer (AVHRR) weekly surface temperature maps, warming of the surface of the Greenland Ice Sheet has been documented since 1981. We extended and refined this record using higher-resolution Moderate-Resolution Imaging Spectroradiometer (MODIS) data from March 2000 to the present. We developed a daily and monthly climate-data record (CDR) of the "clear-sky" surface temperature of the Greenland Ice Sheet using an ice-surface temperature (1ST) algorithm developed for use with MODIS data. Validation of this CDR is ongoing. MODIS Terra swath data are projected onto a polar stereographic grid at 6.25-km resolution to develop binary, gridded daily and mean-monthly 1ST maps. Each monthly map also has a color-coded image map that is available to download. Also included with the monthly maps is an accompanying map showing number of days in the month that were used to calculate the mean-monthly 1ST. This is important because no 1ST decision is made by the algorithm for cells that are considered cloudy by the internal cloud mask, so a sufficient number of days must be available to produce a mean 1ST for each grid cell. Validation of the CDR consists of several facets: 1) comparisons between ISTs and in-situ measurements; 2) comparisons between ISTs and AWS data; and 3) comparisons of ISTs with surface temperatures derived from other satellite instruments such as the Thermal Emission and Reflection Radiometer (ASTER) and Enhanced Thematic Mapper Plus (ETM+). Previous work shows that Terra MODIS ISTs are about 3 C lower than in-situ temperatures measured at Summit Camp, during the winter of 2008-09 under clear skies. In this work we begin to compare surface temperatures derived from AWS data with ISTs from the MODIS CDR. The Greenland Ice Sheet 1ST CDR will be useful for monitoring surface-temperature trends and can be used as input or for validation of climate models. The CDR can be extended into the future using MODIS Terra, Aqua and NPOESS Preparatory Project Visible Infrared Imager Radiometer Suite (VII RS) data.

Colloid micro-Newton thruster development for the ST7-DRS and LISA missions

NASA Technical Reports Server (NTRS)

Ziemer, John K.; Gamero-Castano, Manuel; Hruby, Vlad; Spence, Doug; Demmons, Nate; McCormick, Ryan; Roy, Tom

2005-01-01

We present recent progress and development of the Busek Colloid Micro-Newton Thruster (CMNT) for the Space Technology 7 Disturbance Reduction System (ST7-DRS) and Laser Interferometer Space Antenna (LISA) Missions.

Outreach activities in support of the Missouri S&T national UTC.

DOT National Transportation Integrated Search

2010-02-01

This report describes a comprehensive initiative providing outreach for the Missouri University of Science and Technology (Missouri S&T) National University Transportation Center (NUTC). The goal of this comprehensive outreach program was to provide ...

Development and Implementation of Science and Technology Ethics Education Program for Prospective Science Teachers

NASA Astrophysics Data System (ADS)

Rhee, Hyang-yon; Choi, Kyunghee

2014-05-01

The purposes of this study were (1) to develop a science and technology (ST) ethics education program for prospective science teachers, (2) to examine the effect of the program on the perceptions of the participants, in terms of their ethics and education concerns, and (3) to evaluate the impact of the program design. The program utilized problem-based learning (PBL) which was performed as an iterative process during two cycles. A total of 23 and 29 prospective teachers in each cycle performed team activities. A PBL-based ST ethics education program for the science classroom setting was effective in enhancing participants' perceptions of ethics and education in ST. These perceptions motivated prospective science teachers to develop and implement ST ethics education in their future classrooms. The change in the prospective teachers' perceptions of ethical issues and the need for ethics education was greater when the topic was controversial.

A Toxicology for the 21st Century—Mapping the Road Ahead

PubMed Central

Hartung, Thomas

2009-01-01

The landmark publication by the National Research Council putting forward a vision of a toxicology for the 21st century in 2007 has created an atmosphere of departure in our field. The alliances formed, symposia and meetings held and the articles following are remarkable, indicating that this is an idea whose time has come. Most of the discussion centers on the technical opportunities to map pathways of toxicity and the financing of the program. Here, the other part of the work ahead shall be discussed, that is, the focus is on regulatory implementation once the technological challenges are managed, but we are well aware that the technical aspects of what the National Academy of Science report suggests still need to be addressed: A series of challenges are put forward which we will face in addition to finding a technical solution (and its funding) to set this vision into practice. This includes the standardization and quality assurance of novel methodologies, their formal validation, their integration into test strategies including threshold setting and finally a global acceptance and implementation. This will require intense conceptual steering to have all pieces of the puzzle come together. PMID:19357069

Validity and reliability of GPS and LPS for measuring distances covered and sprint mechanical properties in team sports.

PubMed

Hoppe, Matthias W; Baumgart, Christian; Polglaze, Ted; Freiwald, Jürgen

2018-01-01

This study aimed to investigate the validity and reliability of global (GPS) and local (LPS) positioning systems for measuring distances covered and sprint mechanical properties in team sports. Here, we evaluated two recently released 18 Hz GPS and 20 Hz LPS technologies together with one established 10 Hz GPS technology. Six male athletes (age: 27±2 years; VO2max: 48.8±4.7 ml/min/kg) performed outdoors on 10 trials of a team sport-specific circuit that was equipped with double-light timing gates. The circuit included various walking, jogging, and sprinting sections that were performed either in straight-lines or with changes of direction. During the circuit, athletes wore two devices of each positioning system. From the reported and filtered velocity data, the distances covered and sprint mechanical properties (i.e., the theoretical maximal horizontal velocity, force, and power output) were computed. The sprint mechanical properties were modeled via an inverse dynamic approach applied to the center of mass. The validity was determined by comparing the measured and criterion data via the typical error of estimate (TEE), whereas the reliability was examined by comparing the two devices of each technology (i.e., the between-device reliability) via the coefficient of variation (CV). Outliers due to measurement errors were statistically identified and excluded from validity and reliability analyses. The 18 Hz GPS showed better validity and reliability for determining the distances covered (TEE: 1.6-8.0%; CV: 1.1-5.1%) and sprint mechanical properties (TEE: 4.5-14.3%; CV: 3.1-7.5%) than the 10 Hz GPS (TEE: 3.0-12.9%; CV: 2.5-13.0% and TEE: 4.1-23.1%; CV: 3.3-20.0%). However, the 20 Hz LPS demonstrated superior validity and reliability overall (TEE: 1.0-6.0%; CV: 0.7-5.0% and TEE: 2.1-9.2%; CV: 1.6-7.3%). For the 10 Hz GPS, 18 Hz GPS, and 20 Hz LPS, the relative loss of data sets due to measurement errors was 10.0%, 20.0%, and 15.8%, respectively. This study shows that 18 Hz GPS has enhanced validity and reliability for determining movement patterns in team sports compared to 10 Hz GPS, whereas 20 Hz LPS had superior validity and reliability overall. However, compared to 10 Hz GPS, 18 Hz GPS and 20 Hz LPS technologies had more outliers due to measurement errors, which limits their practical applications at this time.

Clonal success of piliated penicillin nonsusceptible pneumococci

PubMed Central

Sjöström, K.; Blomberg, C.; Fernebro, J.; Dagerhamn, J.; Morfeldt, E.; Barocchi, M. A.; Browall, S.; Moschioni, M.; Andersson, M.; Henriques, F.; Albiger, B.; Rappuoli, Rino; Normark, S.; Henriques-Normark, B.

2007-01-01

Antibiotic resistance in pneumococci is due to the spread of strains belonging to a limited number of clones. The Spain9V-3 clone of sequence type (ST)156 is one of the most successful clones with reduced susceptibility to penicillin [pneumococci nonsusceptible to penicillin (PNSP)]. In Sweden during 2000–2003, a dramatic increase in the number of PNSP isolates was observed. Molecular characterization of these isolates showed that a single clone of sequence type ST156 increased from 40% to 80% of all serotype 14, thus causing the serotype expansion. Additionally, during the same time period, we examined the clonal composition of two serotypes 9V and 19F: all 9V and 20% of 19F isolates belonged to the clonal cluster of ST156, and overall ≈50% of all PNSP belonged to the ST156 clonal cluster. Moreover, microarray and PCR analysis showed that all ST156 isolates, irrespective of capsular type, carried the rlrA pilus islet. This islet was also found to be present in the penicillin-sensitive ST162 clone, which is believed to be the drug-susceptible ancestor of ST156. Competitive experiments between related ST156 serotype 19F strains confirmed that those containing the rlrA pilus islet were more successful in an animal model of carriage. We conclude that the pilus island is an important biological factor common to ST156 isolates and other successful PNSP clones. In Sweden, a country where the low antibiotic usage does not explain the spread of resistant strains, at least 70% of all PNSP isolates collected during year 2003 carried the pilus islet. PMID:17644611

Regulation of Kruppel-like factor 4, 9, and 13 genes and the steroidogenic genes LDLR, StAR, and CYP11A in ovarian granulosa cells.

PubMed

Natesampillai, Sekar; Kerkvliet, Jason; Leung, Peter C K; Veldhuis, Johannes D

2008-02-01

Kruppel-like factors (KLFs) are important Sp1-like eukaryotic transcriptional proteins. The LDLR, StAR, and CYP11A genes exhibit GC-rich Sp1-like sites, which have the potential to bind KLFs in multiprotein complexes. We now report that KLF4, KLF9, and KLF13 transcripts are expressed in and regulate ovarian cells. KLF4 and 13, but not KLF9, mRNA expression was induced and then repressed over time (P < 0.001). Combined LH and IGF-I stimulation increased KLF4 mRNA at 2 h (P < 0.01), whereas LH decreased KLF13 mRNA at 6 h (P < 0.05), and IGF-I reduced KLF13 at 24 h (P < 0.01) compared with untreated control. KLF9 was not regulated by either hormone. Transient transfection of KLF4, KLF9, and KLF13 suppressed LDLR/luc, StAR/luc, and CYP11A/luc by 80-90% (P < 0.001). Histone-deacetylase (HDAC) inhibitors stimulated LDLR/luc five- to sixfold and StAR/luc and CYP11A/luc activity twofold (P < 0.001) and partially reversed suppression by all three KLFs (P < 0.001). Deletion of the zinc finger domain of KLF13 abrogated repression of LDLR/luc. Lentiviral overexpression of the KLF13 gene suppressed LDLR mRNA (P < 0.001) and CYP11A mRNA (P = 0.003) but increased StAR mRNA (P = 0.007). Collectively, these data suggest that KLFs may recruit inhibitory complexes containing HDAC corepressors, thereby repressing LDLR and CYP11A transcription. Conversely, KLF13 may recruit unknown coactivators or stabilize StAR mRNA, thereby explaining enhancement of in situ StAR gene expression. These data introduce new potent gonadal transregulators of genes encoding proteins that mediate sterol uptake and steroid biosynthesis.

We will make you like our research: The development of a susceptibility-to-persuasion scale.

PubMed

Modic, David; Anderson, Ross; Palomäki, Jussi

2018-01-01

Psychological and other persuasive mechanisms across diverse contexts are well researched, with many studies of the effectiveness of specific persuasive techniques on distinct types of human behaviour. In the present paper, our specific interest lies in the development of a generalized modular psychometric tool to measure individuals' susceptibility to persuasion. The scale is constructed using items from previously developed and validated particulate scales established in the domains of social psychology and behavioural economics. In the first study we establish the Susceptibility to Persuasion-II (StP-II) scale, containing 54 items, 10 subscales and further 6 sub-sub scales. In Study 2 we establish the scale's construct validity and reconfirm its reliability. We present a valid and reliable modular psychometric tool that measures general susceptibility to persuasive techniques. Since its inception, we have successfully implemented the StP-II scale to measure susceptibility to persuasion of IT security officers, the role of psychology of persuasion in cybercrime victims and general persuadability levels of Facebook users; these manuscripts are in preparation. We argue that the StP-II scale shows promise in measuring individual differences in susceptibility to persuasion, and is applicable across diverse contexts such as Internet security and cybercrime.

Generation and validation of PAX7 reporter lines from human iPS cells using CRISPR/Cas9 technology.

PubMed

Wu, Jianbo; Hunt, Samuel D; Xue, Haipeng; Liu, Ying; Darabi, Radbod

2016-03-01

Directed differentiation of iPS cells toward various tissue progenitors has been the focus of recent research. Therefore, generation of tissue-specific reporter iPS cell lines provides better understanding of developmental stages in iPS cells. This technical report describes an efficient strategy for generation and validation of knock-in reporter lines in human iPS cells using the Cas9-nickase system. Here, we have generated a knock-in human iPS cell line for the early myogenic lineage specification gene of PAX7. By introduction of site-specific double-stranded breaks (DSB) in the genomic locus of PAX7 using CRISPR/Cas9 nickase pairs, a 2A-GFP reporter with selection markers has been incorporated before the stop codon of the PAX7 gene at the last exon. After positive and negative selection, single cell-derived human iPS clones have been isolated and sequenced for in-frame positioning of the reporter construct. Finally, by using a nuclease-dead Cas9 activator (dCas9-VP160) system, the promoter region of PAX7 has been targeted for transient gene induction to validate the GFP reporter activity. This was confirmed by flow cytometry analysis and immunostaining for PAX7 and GFP. This technical report provides a practical guideline for generation and validation of knock-in reporters using CRISPR/Cas9 system. Published by Elsevier B.V.

Recent emergence of clonal group O25b:K1:H4-B2-ST131 ibeA strains among Escherichia coli poultry isolates, including CTX-M-9-producing strains, and comparison with clinical human isolates.

PubMed

Mora, Azucena; Herrera, Alexandra; Mamani, Rosalia; López, Cecilia; Alonso, María Pilar; Blanco, Jesús E; Blanco, Miguel; Dahbi, Ghizlane; García-Garrote, Fernando; Pita, Julia María; Coira, Amparo; Bernárdez, María Isabel; Blanco, Jorge

2010-11-01

To discern the possible spread of the Escherichia coli O25b:H4-ST131 clonal group in poultry and the zoonotic potential of avian strains, we made a retrospective search of our strain collection and compared the findings for those strains with the findings for current strains. Thus, we have characterized a collection of 19 avian O25b:H4-ST131 E. coli strains isolated from 1995 to 2010 which, interestingly, harbored the ibeA gene. Using this virulence gene as a criterion for selection, we compared those 19 avian strains with 33 human O25b:H4-ST131 ibeA-positive E. coli strains obtained from patients with extraintestinal infections (1993 to 2009). All 52 O25b:H4-ST131 ibeA-positive E. coli strains shared the fimH, kpsMII, malX, and usp genes but showed statistically significant differences in nine virulence factors, namely, papGIII, cdtB, sat, and kpsMII K5, which were associated with human strains, and iroN, kpsMII K1, cvaC, iss, and tsh, which were associated with strains of avian origin. The XbaI macrorestriction profiles of the 52 E. coli O25b:H4-ST131 ibeA-positive strains revealed 11 clusters (clusters I to XI) of >85% similarity, with four clusters including strains of human and avian origin. Cluster VII (90.9% similarity) grouped 10 strains (7 avian and 3 human strains) that mostly produced CTX-M-9 and that also shared the same virulence profile. Finally, we compared the macrorestriction profiles of the 12 CTX-M-9-producing O25b:H4-ST131 ibeA strains (7 avian and 5 human strains) identified among the 52 strains with those of 15 human O25b:H4-ST131 CTX-M-14-, CTX-M-15-, and CTX-M-32-producing strains that proved to be negative for ibeA and showed that they clearly differed in the level of similarity from the CTX-M-9-producing strains. In conclusion, E. coli clonal group O25b:H4-ST131 ibeA has recently emerged among avian isolates with the new acquisition of the K1 capsule antigen and includes CTX-M-9-producing strains. This clonal group represents a real zoonotic risk that has crossed the barrier between human and avian hosts.

Development and Validation of A Scheduled Shifts Staffing (ASSiST) Measure of Unit-Level Staffing in Nursing Homes.

PubMed

Cummings, Greta G; Doupe, Malcolm; Ginsburg, Liane; McGregor, Margaret J; Norton, Peter G; Estabrooks, Carole A

2017-06-01

To (a) describe A Scheduled Shifts Staffing measure (ASSiST) to derive care aide worked hours per resident day (HCA WHRD) at facility and unit levels in nursing homes, (b) report reliability through comparisons to administrative staffing data; (c) report validity by examining associations between HCA WHRD, staff outcomes (job satisfaction, emotional exhaustion), and resident quality indicators (QIs) (e.g. falls, delirium, stage 2+ pressure ulcers), and (d) explore intrafacility variation in staffing intensity levels related to unit-level variation in resident and staff outcomes. We used data from 40 care units in 12 Canadian nursing homes between 2007 and 2012. Descriptive statistics and tests of association and difference described relationships of two measures of staffing with resident and staff outcomes. Annualized rates of HCA WHRD from both data sources compared well at the facility level (Pearson Product Correlation; R = 0.847, p < .001), and were correlated similarly to staff work life and many QIs. Using ASSiST data, we show that staffing levels can vary by up to 40% at the unit-level within nursing homes. ASSiST is easy to collect, more timely to retrieve than administrative data, has good criterion and construct validity, and reflects intrafacility variation in health care aide staffing levels. © The Author 2016. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Multidimensional Space-Time Methodology for Development of Planetary and Space Sciences, S-T Data Management and S-T Computational Tomography

NASA Astrophysics Data System (ADS)

Andonov, Zdravko

This R&D represent innovative multidimensional 6D-N(6n)D Space-Time (S-T) Methodology, 6D-6nD Coordinate Systems, 6D Equations, new 6D strategy and technology for development of Planetary Space Sciences, S-T Data Management and S-T Computational To-mography. . . The Methodology is actual for brain new RS Microwaves' Satellites and Compu-tational Tomography Systems development, aimed to defense sustainable Earth, Moon, & Sun System evolution. Especially, extremely important are innovations for monitoring and protec-tion of strategic threelateral system H-OH-H2O Hydrogen, Hydroxyl and Water), correspond-ing to RS VHRS (Very High Resolution Systems) of 1.420-1.657-22.089GHz microwaves. . . One of the Greatest Paradox and Challenge of World Science is the "transformation" of J. L. Lagrange 4D Space-Time (S-T) System to H. Minkovski 4D S-T System (O-X,Y,Z,icT) for Einstein's "Theory of Relativity". As a global result: -In contemporary Advanced Space Sciences there is not real adequate 4D-6D Space-Time Coordinate System and 6D Advanced Cosmos Strategy & Methodology for Multidimensional and Multitemporal Space-Time Data Management and Tomography. . . That's one of the top actual S-T Problems. Simple and optimal nD S-T Methodology discovery is extremely important for all Universities' Space Sci-ences' Education Programs, for advances in space research and especially -for all young Space Scientists R&D!... The top ten 21-Century Challenges ahead of Planetary and Space Sciences, Space Data Management and Computational Space Tomography, important for successfully de-velopment of Young Scientist Generations, are following: 1. R&D of W. R. Hamilton General Idea for transformation all Space Sciences to Time Sciences, beginning with 6D Eukonal for 6D anisotropic mediums & velocities. Development of IERS Earth & Space Systems (VLBI; LLR; GPS; SLR; DORIS Etc.) for Planetary-Space Data Management & Computational Planetary & Space Tomography. 2. R&D of S. W. Hawking Paradigm for 2D Complex Time and Quan-tum Wave Cosmology Paradigm for Decision of the Main Problem of Contemporary Physics. 3. R&D of Einstein-Minkowski Geodesies' Paradigm in the 4D-Space-Time Continuum to 6D-6nD Space-Time Continuum Paradigms and 6D S-T Equations. . . 4. R&D of Erwin Schrüdinger 4D S-T Universe' Evolutional Equation; It's David Bohm 4D generalization for anisotropic mediums and innovative 6D -for instantaneously quantum measurement -Bohm-Schrüdinger 6D S-T Universe' Evolutional Equation. 5. R&D of brain new 6D Planning of S-T Experi-ments, brain new 6D Space Technicks and Space Technology Generalizations, especially for 6D RS VHRS Research, Monitoring and 6D Computational Tomography. 6. R&D of "6D Euler-Poisson Equations" and "6D Kolmogorov Turbulence Theory" for GeoDynamics and for Space Dynamics as evolution of Gauss-Riemann Paradigms. 7. R&D of N. Boneff NASA RD for Asteroid "Eros" & Space Science' Laws Evolution. 8. R&D of H. Poincare Paradigm for Nature and Cosmos as 6D Group of Transferences. 9. R&D of K. Popoff N-Body General Problem & General Thermodynamic S-T Theory as Einstein-Prigogine-Landau' Paradigms Development. ü 10. R&D of 1st GUT since 1958 by N. S. Kalitzin (Kalitzin N. S., 1958: Uber eine einheitliche Feldtheorie. ZAHeidelberg-ARI, WZHUmnR-B., 7 (2), 207-215) and "Multitemporal Theory of Relativity" -With special applications to Photon Rockets and all Space-Time R&D. GENERAL CONCLUSION: Multidimensional Space-Time Methodology is advance in space research, corresponding to the IAF-IAA-COSPAR Innovative Strategy and R&D Programs -UNEP, UNDP, GEOSS, GMES, Etc.

Nine-Months Clinical Outcome of Biodegradable Polymer Coated Sirolimus-eluting Stent System: A Multi-Centre "Real-World" Experience.

PubMed

Sarma, Raghava; Prajapati, Jayesh; Raheem, Asif; Thakkar, Kamlesh; Kothari, Shivani; Thakkar, Ashok

2015-08-01

The main culprit in first-generation drug eluting stents is 'durable' polymer, whose continuous presence may impair arterial healing and ultimately have a negative impact on late outcomes. The main enigma behind the biodegradable polymer usage is its degradation after elution of drug. This reduces adverse events in unselected patients with complex coronary artery lesions treated with biodegradable polymer coated sirolimus-eluting stents. The aim of the INDOLIMUS-G Registry was to evaluate safety and efficacy of the Indolimus (Sahajanand Medical Technologies Pvt. Ltd., Surat, India) sirolimus-eluting stents in large cohorts of unselected patients with complex coronary artery lesions. It is a multi-centre, non-randomized retrospective registry with a clear aim of evaluating safety and efficacy of the Indolimus sirolimus-eluting stents in consecutive patients enrolled between April 2012 and May 2014. The primary end-point of the study was major adverse cardiac events (MACE), which is a composite of cardiac death, myocardial infarction (MI), target lesion revascularization (TLR), target vessel revascularization (TVR) and stent thrombosis (ST) at the end of follow-up. Clinical follow-up were scheduled at the end of 30-days, 6-months, and 9-months period. The mean age of enrolled patients was 52.6 ± 11.0 years. A total of 1137 lesions were intervened successfully with 1242 stents (1.09 ± 0.30 stent per lesion). The average stent length and diameter was 27.42 ± 9.01 mm and 3.12 ± 0.36 mm respectively. There were 740 (73.40%) male patients, indicating their high prevalence. Diabetes, hypertension and totally occluded lesions were found in 372 (36.90%), 408 (40.47%) and 170 (16.86%) patients, respectively. This showed that study also included high risk complex lesions and not ideal recruited lesions. The incidence of MACE at 30-days, 6-months and 9-months were 3 (0.30%), 18 (1.80%) and 22 (2.20%) respectively. At 9-months, TLR was found in 6 (0.50%) patients. There were 2 (0.20%) cases of ST, 10 (1.0%) cases of MI and 4 (0.40%) cases of cardiac death at 9-month follow-up. The lower incidence of MACE, TLR and ST at 9-month follow-up clearly delineates safety and efficacy of Indolimus SES in large cohorts of unselected patients with complex coronary lesions.

FIRST LEGO League Kickoff

NASA Technical Reports Server (NTRS)

2007-01-01

Randall Hicks (right), Jacobs Technology's Education Services manager at NASA John C. Stennis Space Center, answers questions about the playing field for FIRST (For Inspiration and Recognition of Science and Technology) LEGO League's 2007 Challenge, `Power Puzzle.' More than 140 teachers, mentors, parents and students from 15 schools attended the Sept. 15 FLL season kickoff at StenniSphere, the visitor center at SSC. The teams from southern and central Mississippi and Mobile, Ala., who came to SSC heard rules for and asked questions about `Power Puzzle,' and saw robot demonstrations by Gulfport and Picayune high schools' past FIRST Robotics competitions. Using LEGO Mindstorms NXT kits, FLL teams of children ages 9-14 will spend the next three months building and programming robots to perform 'Power Puzzle's' challenge tasks, then pit them in competitions. They also will submit a research project about how energy choices impact the environment and the economy. The season will culminate at the Mississippi Championship Tournament on Dec. 8 at the Mississippi Gulf Coast Community College. FLL, considered the `little league' of the FIRST Robotics Competition, partners FIRST and the LEGO Group. Competitions aim to inspire and celebrate science and technology using real-world context and hands-on experimentation. NASA recognizes FIRST activities as an excellent hands-on method to increase student knowledge of science, engineering, technology and mathematics. Schools represented in this year's kickoff were: Madison Avenue Upper Elementary, the Mississippi Band of Choctaw Indians' Conehatta Elementary, Hattiesburg's Lillie Burney Elementary, Pearl Upper Elementary, Long Beach Middle, Oktibehha Elementary, d'Iberville Middle, Saucier's West Wortham Middle, Picayune's Nicholson Elementary and Roseland Park Baptist Church Academy, Bay St. Louis' St. Stanislaus College and Mobile's Davidson High, as well as two home-school groups from the Jackson area.

FIRST LEGO League Kickoff

NASA Image and Video Library

2007-09-15

Randall Hicks (right), Jacobs Technology's Education Services manager at NASA John C. Stennis Space Center, answers questions about the playing field for FIRST (For Inspiration and Recognition of Science and Technology) LEGO League's 2007 Challenge, `Power Puzzle.' More than 140 teachers, mentors, parents and students from 15 schools attended the Sept. 15 FLL season kickoff at StenniSphere, the visitor center at SSC. The teams from southern and central Mississippi and Mobile, Ala., who came to SSC heard rules for and asked questions about `Power Puzzle,' and saw robot demonstrations by Gulfport and Picayune high schools' past FIRST Robotics competitions. Using LEGO Mindstorms NXT kits, FLL teams of children ages 9-14 will spend the next three months building and programming robots to perform 'Power Puzzle's' challenge tasks, then pit them in competitions. They also will submit a research project about how energy choices impact the environment and the economy. The season will culminate at the Mississippi Championship Tournament on Dec. 8 at the Mississippi Gulf Coast Community College. FLL, considered the `little league' of the FIRST Robotics Competition, partners FIRST and the LEGO Group. Competitions aim to inspire and celebrate science and technology using real-world context and hands-on experimentation. NASA recognizes FIRST activities as an excellent hands-on method to increase student knowledge of science, engineering, technology and mathematics. Schools represented in this year's kickoff were: Madison Avenue Upper Elementary, the Mississippi Band of Choctaw Indians' Conehatta Elementary, Hattiesburg's Lillie Burney Elementary, Pearl Upper Elementary, Long Beach Middle, Oktibehha Elementary, d'Iberville Middle, Saucier's West Wortham Middle, Picayune's Nicholson Elementary and Roseland Park Baptist Church Academy, Bay St. Louis' St. Stanislaus College and Mobile's Davidson High, as well as two home-school groups from the Jackson area.

[Evaluation of therapeutic-prophylactic effectiveness of chemical compound NIOC-14 against ectromelia virus in vivo].

PubMed

Kabanov, A S; Shishkina, L N; Mazurkov, O Iu; Skarnovich, M O; Bormotov, N I; Serova, O A; Sergeev, Al A; Sergeev, Ar A; Selivanov, B A; Tikhonov, A Iu; Agafonov, A P; Sergeev, A N

2015-01-01

Study pharmacodynamic parameters of anti-viral effectiveness of a chemical compound NIOC-14 in experiments in mice infected with ectromelia virus (EV). EV (K-1 strain) was obtained from the State Collection of Viral Infections and Rickettsioses Causative Agents of the State Scientific Centre of Virology and Biotechnology "Vector". Outbred ICR mice were intranasally infected with EV at a dose of 10 LD50 per animal (10 x 50% lethal doses/animal) and per orally received NIOC-14 or ST-246 as a positive control. Chemical compound NIOC-14 (7-[N'-(4-trifluoromethylbenzoyl)-hidrazincarbonyl]-tricyclo[3.2.2.0(2,4)]non-8-en-6-carbonic acid) was synthesized in Novosibirsk Institute of Organic Chemistry (NIOC). Anti-pox preparation ST-246, developed by SIGA Technologies Inc. (USA), was synthesized in NIOC using the technique described by the authors. 50% effective doses against EV in vivo were shown not to differ significantly between the preparations NIOC-14 (3.59 μg/g mouse mass) and ST-246 (5.08 μg/g mouse mass). During determination of therapeutic window, administration of NIOC-14 to mice 1 day or 1 hour before EV infection, as well as 1, 2 and 4 days after EV infection and then for 9 days was found to ensure 100% animal survival. Administration of NIOC-14 as well as ST-246 resulted in the decrease relative to control of EV titers in lungs, nasal cavity, brains, liver, spleen, kidneys and pancreas. Anti-viral effectiveness of NIOC-14 against EV in vivo was thus comparable by all the studied pharmacodynamic parameters with anti-viral activity of anti-pox-virus preparation ST-246.

Efficient hit-finding approaches for histone methyltransferases: the key parameters.

PubMed

Ahrens, Thomas; Bergner, Andreas; Sheppard, David; Hafenbradl, Doris

2012-01-01

For many novel epigenetics targets the chemical ligand space and structural information were limited until recently and are still largely unknown for some targets. Hit-finding campaigns are therefore dependent on large and chemically diverse libraries. In the specific case of the histone methyltransferase G9a, the authors have been able to apply an efficient process of intelligent selection of compounds for primary screening, rather than screening the full diverse deck of 900 000 compounds to identify hit compounds. A number of different virtual screening methods have been applied for the compound selection, and the results have been analyzed in the context of their individual success rates. For the primary screening of 2112 compounds, a FlashPlate assay format and full-length histone H3.1 substrate were employed. Validation of hit compounds was performed using the orthogonal fluorescence lifetime technology. Rated by purity and IC(50) value, 18 compounds (0.9% of compound screening deck) were finally considered validated primary G9a hits. The hit-finding approach has led to novel chemotypes being identified, which can facilitate hit-to-lead projects. This study demonstrates the power of virtual screening technologies for novel, therapeutically relevant epigenetics protein targets.

Validation of the Omron HEM-7320-LA, upper arm blood pressure monitor with Intelli Wrap Technology Cuff HEM-FL1 for self-measurement and clinic use according to the European Society of Hypertension International Protocol revision 2010 in the Mexican population.

PubMed

Grover-Páez, Fernando; Cardona-Muñoz, Ernesto G; Cardona-Müller, David; Guzmán-Saldívar, Víctor H; Rodríguez-De la Cerda, Mariana; Jiménez-Cázarez, Mayra B; Totsuka-Sutto, Sylvia E; Alanis-Sánchez, Guillermo A; Ramos-Becerra, Carlos G

2017-12-01

The aim of this study was to determine the accuracy of the Omron HEM-7320-LA with Intelli Wrap technology cuff HEM-FL1 for self-measurement and clinic blood pressure (BP) measurement according to the European Society of Hypertension International Protocol revision 2010. The evaluation was performed in 39 individuals. The mean age of the participants was 47.9±14 years; systolic BP was 145.2±24.3 mmHg (range: 97-190), diastolic BP was 90.9±12.9 mmHg (range: 68-120), and arm circumference was 30.8±4 cm (range: 25-38.5). The device successfully fulfilled the established criteria of the validation protocol. The device overestimated systolic BP by 0.6±5.7 mmHg and diastolic BP by 2.2±5.1 mmHg. The specially designed cuff HEM-FL1 to cover a broad range of arm circumferences and self-placement fulfilled the requirements of the International Protocol.

Customized vs INTERGROWTH-21st standards for the assessment of birthweight and stillbirth risk at term.

PubMed

Francis, Andre; Hugh, Oliver; Gardosi, Jason

2018-02-01

Fetal growth abnormalities are linked to stillbirth and other adverse pregnancy outcomes, and use of the correct birthweight standard is essential for accurate assessment of growth status and perinatal risk. Two competing, conceptually opposite birthweight standards are currently being implemented internationally: customized gestation-related optimal weight (GROW) and INTERGROWTH-21 st . We wanted to compare their performance when applied to a multiethnic international cohort, and evaluate their usefulness in the assessment of stillbirth risk at term. We analyzed routinely collected maternity data from 10 countries with a total of 1.25 million term pregnancies in their respective main ethnic groups. The 2 standards were applied to determine small for gestational age (SGA) and large for gestational age (LGA) rates, with associated relative risk and population-attributable risk of stillbirth. The customized standard (GROW) was based on the term optimal weight adjusted for maternal height, weight, parity, and ethnic origin, while INTERGROWTH-21 st was a fixed standard derived from a multiethnic cohort of low-risk pregnancies. The customized standard showed an average SGA rate of 10.5% (range 10.1-12.7) and LGA rate of 9.5% (range 7.3-9.9) for the set of cohorts. In contrast, there was a wide variation in SGA and LGA rates with INTERGROWTH-21 st , with an average SGA rate of 4.4% (range 3.1-16.8) and LGA rate of 20.6% (range 5.1-27.5). This variation in INTERGROWTH-21 st SGA and LGA rates was correlated closely (R = ±0.98) to the birthweights predicted for the 10 country cohorts by the customized method to derive term optimal weight, suggesting that they were mostly due to physiological variation in birthweight. Of the 10.5% of cases defined as SGA according to the customized standard, 4.3% were also SGA by INTERGROWTH-21 st and had a relative risk of 3.5 (95% confidence interval, 3.1-4.1) for stillbirth. A further 6.3% (60% of the whole customized SGA) were not SGA by INTERGROWTH-21 st , and had a relative risk of 1.9 (95% confidence interval, 3.1-4.1) for stillbirth. An additional 0.2% of cases were SGA by INTERGROWTH-21 st only, and had no increased risk of stillbirth. At the other end, customized assessment classified 9.5% of births as large for gestational age, most of which (9.0%) were also LGA by the INTERGROWTH-21 st standard. INTERGROWTH-21 st identified a further 11.6% as LGA, which, however, had a reduced risk of stillbirth (relative risk, 0.6; 95% confidence interval, 0.5-0.7). Customized assessment resulted in increased identification of small for gestational age and stillbirth risk, while the wide variation in SGA rates using the INTERGROWTH-21 st standard appeared to mostly reflect differences in physiological pregnancy characteristics in the 10 maternity populations. Copyright © 2018 Elsevier Inc. All rights reserved.

Measurement Instrument for Scientific Teaching (MIST): A Tool to Measure the Frequencies of Research-Based Teaching Practices in Undergraduate Science Courses.

PubMed

Durham, Mary F; Knight, Jennifer K; Couch, Brian A

2017-01-01

The Scientific Teaching (ST) pedagogical framework provides various approaches for science instructors to teach in a way that more closely emulates how science is practiced by actively and inclusively engaging students in their own learning and by making instructional decisions based on student performance data. Fully understanding the impact of ST requires having mechanisms to quantify its implementation. While many useful instruments exist to document teaching practices, these instruments only partially align with the range of practices specified by ST, as described in a recently published taxonomy. Here, we describe the development, validation, and implementation of the Measurement Instrument for Scientific Teaching (MIST), a survey derived from the ST taxonomy and designed to gauge the frequencies of ST practices in undergraduate science courses. MIST showed acceptable validity and reliability based on results from 7767 students in 87 courses at nine institutions. We used factor analyses to identify eight subcategories of ST practices and used these categories to develop a short version of the instrument amenable to joint administration with other research instruments. We further discuss how MIST can be used by instructors, departments, researchers, and professional development programs to quantify and track changes in ST practices. © 2017 M. F. Durham et al. CBE—Life Sciences Education © 2017 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Five Forces of 21st Century Innovation Strategy: Insights for Leaders

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arent, Douglas J.; Pless, Jacquelyn; Statwick, Patricia

Understanding these dynamics informs 21st century innovation strategies that government and business leaders rely upon to address modern technological, social, environmental, and demographic realities. This Research Highlight previews JISEA's continuing work on innovation strategy.

Hydrogen applications for Lambert-St. Louis International Airport

DOT National Transportation Integrated Search

2009-01-01

Today, major airports are facing challenges related to pollution, energy efficiency, and safety and security. Hydrogen and fuel cell technologies, regarded as one of the key energy solutions of the 21st century are more energy efficient and reliable ...

Whole genome sequencing, molecular typing and in vivo virulence of OXA-48-producing Escherichia coli isolates including ST131 H30-Rx, H22 and H41 subclones.

PubMed

de Toro, María; Fernández, Javier; García, Vanesa; Mora, Azucena; Blanco, Jorge; de la Cruz, Fernando; Rodicio, M Rosario

2017-09-21

Carbapenem-resistant Enterobacteriaceae, including the increasingly reported OXA-48 Escherichia coli producers, are an emerging public health threat worldwide. Due to their alarming detection in our healthcare setting and their possible presence in the community, seven OXA-48-producing, extraintestinal pathogenic E. coli were analysed by whole genome sequencing as well as conventional tools, and tested for in vivo virulence. As a result, five E. coli OXA-48-producing subclones were detected (O25:H4-ST131/PST43-fimH30-virotype E; O25:H4-ST131/PST9-fimH22-virotype D5, O16:H5-ST131/PST506-fimH41; O25:H5-ST83/PST207 and O9:H25-ST58/PST24). Four ST131 and one ST83 isolates satisfied the ExPEC status, and all except the O16:H5 ST131 isolate were UPEC. All isolates exhibited local inflammatory response with extensive subcutaneous necrosis but low lethality when tested in a mouse sepsis model. The bla OXA-48 gene was located in MOB P131 /IncL plasmids (four isolates) or within the chromosome (three ST131 H30-Rx isolates), carried by Tn1999-like elements. All, except the ST83 isolate, were multidrug-resistant, with additional plasmids acting as vehicles for the spread of various resistance genes. This is the first study to analyse the whole genome sequences of bla OXA-48 -positive ST131, ST58 and ST83 E. coli isolates in conjunction with experimental data, and to evaluate the in vivo virulence of bla OXA-48 isolates, which pose an important challenge to patient management.

Subtype distribution of Blastocystis spp. isolated from children in Eskisehir, Turkey.

PubMed

Dogan, Nihal; Aydin, Merve; Tuzemen, Nazmiye Ulku; Dinleyici, Ener Cagri; Oguz, Ilkiz; Dogruman-Al, Funda

2017-02-01

Blastocystis spp. is the most common enteric protist found in human feces. The pathogenic role of Blastocystis remains controversial and it has been suggested that the symptomatology of Blastocystis is associated with its subtypes (ST). However, only few studies have investigated the relationship between the symptomatology and subtypes of Blastocystis in children. This study aimed to investigate the prevalence of Blastocystis in children aged 3 to 13years with or without gastrointestinal complaints and determine the distribution of the subtypes of Blastocystis. A total of 303 stool samples obtained from symptomatic (n=84) and asymptomatic (n=219) children were included in the study. The presence of Blastocystis was investigated using native-lugol examination, trichrome staining and real-time PCR method. Using the real-time PCR method, 115 samples were found positive for Blastocystis. Subtyping was successfully performed on 46 samples using sequenced-tagged site (STS) primers and PCR. The remaining 69 samples could not be subtyped. The most frequently detected subtype was ST3 (43.4%) followed by ST1 (26.1%), ST4 (10.9%) and ST2 (8.7%). The mixed subtypes were identified in five samples (10.9%) as; ST1+ST3 (n=3), ST1+ST2 (n=1) and ST2+ST3 (n=1). None of the samples had ST5, ST6 or ST7. No statistically significant difference was found between the symptomatic and asymptomatic groups in terms of the Blastocystis positivity and the distribution of subtypes (p>0.05). To our knowledge, this is the first study to investigate the subtype distribution of Blastocystis in children in Turkey and the results are in agreement with the related data available in Turkey. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Transformations in Air Transportation Systems For the 21st Century

NASA Technical Reports Server (NTRS)

Holmes, Bruce J.

2004-01-01

Globally, our transportation systems face increasingly discomforting realities: certain of the legacy air and ground infrastructures of the 20th century will not satisfy our 21st century mobility needs. The consequence of inaction is diminished quality of life and economic opportunity for those nations unable to transform from the 20th to 21st century systems. Clearly, new thinking is required regarding business models that cater to consumers value of time, airspace architectures that enable those new business models, and technology strategies for innovating at the system-of-networks level. This lecture proposes a structured way of thinking about transformation from the legacy systems of the 20th century toward new systems for the 21st century. The comparison and contrast between the legacy systems of the 20th century and the transformed systems of the 21st century provides insights into the structure of transformation of air transportation. Where the legacy systems tend to be analog (versus digital), centralized (versus distributed), and scheduled (versus on-demand) for example, transformed 21st century systems become capable of scalability through technological, business, and policy innovations. Where air mobility in our legacy systems of the 20th century brought economic opportunity and quality of life to large service markets, transformed air mobility of the 21st century becomes more equitable available to ever-thinner and widely distributed populations. Several technological developments in the traditional aircraft disciplines as well as in communication, navigation, surveillance and information systems create new foundations for 21st thinking about air transportation. One of the technological developments of importance arises from complexity science and modern network theory. Scale-free (i.e., scalable) networks represent a promising concept space for modeling airspace system architectures, and for assessing network performance in terms of robustness, resilience, and other metrics. The lecture offers an air transportation system topology and a scale-free network linkage graphic as framework for transportation system innovation. Successful outcomes of innovation in air transportation could lay the foundations for new paradigms for aircraft and their operating capabilities, air transportation system topologies, and airspace architectures and procedural concepts. These new paradigms could support scalable alternatives for the expansion of future air mobility to more consumers in more parts of the world.

Draft genome sequences of 9 LA-MRSA ST5 isolates from humans with long term swine contact

USDA-ARS?s Scientific Manuscript database

Humans have been found to harbor livestock associated methicillin resistant Staphylococcus aureus (LA-MRSA) isolates. LA-MRSA are considered adapted to colonizing livestock and less pathogenic than their hospital and community counterparts. Here, we present 9 LA-MRSA ST5 isolates from veterinarians ...

Working towards a consensus for antibody validation.

PubMed

Reiss, Peter D; Min, Danxi; Leung, Mei Y

2014-01-01

Commercial research antibodies are the most commonly used product in the life science tools market, and their applications represent a significant investment of time and resources for researchers. Frequently however, the quality of antibodies does not meet the expectations of consumers, causing loss of valuable time and money. This can delay research efforts and scientific discovery, or even lead to false, irreproducible results to be published in the scientific literature. This raises the question of whether there should be universal standards for validating antibodies.   During the 1 (st) International Antibody Validation Forum, hosted by St John's Laboratory Ltd on October 15 (th) 2014 at Queen Mary University of London, scientists from academia and industry presented data highlighting quality issues arising from lack of antibody validation. While the forum identified significant current problems in the antibody market, it also discussed future opportunities for improved quality and transparency by encouraging data disclosure and data sharing. This article highlights the key issues and conclusions reached at the forum.

(abstract) Generic Modeling of a Life Support System for Process Technology Comparisons

NASA Technical Reports Server (NTRS)

Ferrall, J. F.; Seshan, P. K.; Rohatgi, N. K.; Ganapathi, G. B.

1993-01-01

This paper describes a simulation model called the Life Support Systems Analysis Simulation Tool (LiSSA-ST), the spreadsheet program called the Life Support Systems Analysis Trade Tool (LiSSA-TT), and the Generic Modular Flow Schematic (GMFS) modeling technique. Results of using the LiSSA-ST and the LiSSA-TT will be presented for comparing life support systems and process technology options for a Lunar Base and a Mars Exploration Mission.

JPRS Report, Science & Technology. Japan: Economic Planning Agency Technology Forecast to the Year 2010.

DTIC Science & Technology

1991-11-17

are several concrete examples of how these affect application. (1) For the development and spread of solar photoelectric power generation, under the...technician in charge of each generator. In order to promote the installation of solar cells at various households and businesses, the relevant laws must be...products from microorganisms ’ Solar photoelectric power Communications satellites Skyscrapers Alone in 1st Tied for 1st 10 Years Ago Present !i

Strontium

USGS Publications Warehouse

Angulo, M.A.

2011-01-01

In 2010, U.S. apparent consumption of strontium (contained in celestite and manufactured strontium compounds) decreased by 11 percent to 10.4 kt (11,460 st) from 11.8 kt (13,000 st) in 2009. Gross weight of imports totaled 20.9 kt (23,000 st), of which 65 percent originated from Mexico.

ACHP | News | St. Elizabeths Programmatic Agreement Signed

Science.gov Websites

Search skip specific nav links Home arrow News arrow St. Elizabeths Programmatic Agreement Signed St . Elizabeths Programmatic Agreement Signed December 9, 2008-- The General Services Administration (GSA), the ), and the Department of Homeland Security (DHS) executed a Programmatic Agreement (PA) for the

33 CFR 117.261 - Atlantic Intracoastal Waterway from St. Marys River to Key Largo.

Code of Federal Regulations, 2010 CFR

2010-07-01

... from St. Marys River to Key Largo. 117.261 Section 117.261 Navigation and Navigable Waters COAST GUARD....261 Atlantic Intracoastal Waterway from St. Marys River to Key Largo. (a) General. Public vessels of..., mile 777.9 at St. Augustine. The draw shall open on signal; except that, from 7 a.m. to 6 p.m. the draw...

75 FR 34362 - Safety Zone; Festivals & Fireworks Celebration, East Moran Bay, Lake Huron, St. Ignace, MI

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-17

...-AA00 Safety Zone; Festivals & Fireworks Celebration, East Moran Bay, Lake Huron, St. Ignace, MI AGENCY... safety zone on East Moran Bay, Lake Huron, St. Ignace, MI. This zone is intended to restrict vessels from... portion of East Moran Bay, Lake Huron, St. Ignace, MI between 9 p.m. and 11 p.m. on June 26, July 10, July...

On School Educational Technology Leadership

ERIC Educational Resources Information Center

Davies, Patricia M.

2010-01-01

This analysis of the literatures on school educational technology leadership addresses definitions of school technology leaders and leadership, their role in educational change, and why schools are now changing as a result of 21st century advancements in technology. The literatures disagree over the definition of educational technology leadership.…

Diversity and distribution of Listeria monocytogenes in meat processing plants.

PubMed

Martín, Belén; Perich, Adriana; Gómez, Diego; Yangüela, Javier; Rodríguez, Alicia; Garriga, Margarita; Aymerich, Teresa

2014-12-01

Listeria monocytogenes is a major concern for the meat processing industry because many listeriosis outbreaks have been linked to meat product consumption. The aim of this study was to elucidate L. monocytogenes diversity and distribution across different Spanish meat processing plants. L. monocytogenes isolates (N = 106) collected from food contact surfaces of meat processing plants and meat products were serotyped and then characterised by multilocus sequence typing (MLST). The isolates were serotyped as 1/2a (36.8%), 1/2c (34%), 1/2b (17.9%) and 4b (11.3%). MLST identified ST9 as the most predominant allelic profile (33% of isolates) followed by ST121 (16%), both of which were detected from several processing plants and meat products sampled in different years, suggesting that those STs are highly adapted to the meat processing environment. Food contact surfaces during processing were established as an important source of L. monocytogenes in meat products because the same STs were obtained in isolates recovered from surfaces and products. L. monocytogenes was recovered after cleaning and disinfection procedures in two processing plants, highlighting the importance of thorough cleaning and disinfection procedures. Epidemic clone (EC) marker ECI was identified in 8.5%, ECIII was identified in 2.8%, and ECV was identified in 7.5% of the 106 isolates. Furthermore, a selection of presumably unrelated ST9 isolates was analysed by multi-virulence-locus sequence typing (MVLST). Most ST9 isolates had the same virulence type (VT11), confirming the clonal origin of ST9 isolates; however, one ST9 isolate was assigned to a new VT (VT95). Consequently, MLST is a reliable tool for identification of contamination routes and niches in processing plants, and MVLST clearly differentiates EC strains, which both contribute to the improvement of L. monocytogenes control programs in the meat industry. Copyright © 2014 Elsevier Ltd. All rights reserved.

Development and Initial Validation of the Student Rating of Environmental Stressors Scale: Stressors Faced by Students in Accelerated High School Curricula

ERIC Educational Resources Information Center

Suldo, Shannon M.; Dedrick, Robert F.; Shaunessy-Dedrick, Elizabeth; Roth, Rachel A.; Ferron, John

2015-01-01

High school students in accelerated curricula face stressors beyond typical adolescent developmental challenges. The Student Rating of Environmental Stressors Scale (StRESS) is a self-report measure of environmental stressors appropriate for students in Advanced Placement (AP) and International Baccalaureate (IB) courses. We developed the StRESS…

A cross-cultural validation of the Technology-Rich Outcomes-Focused Learning Environment Inventory (TROFLEI) in Turkey and the USA

NASA Astrophysics Data System (ADS)

Welch, Anita G.; Cakir, Mustafa; Peterson, Claudette M.; Ray, Chris M.

2012-04-01

Background . Studies exploring the relationship between students' achievement and the quality of the classroom learning environments have shown that there is a strong relationship between these two concepts. Learning environment instruments are constantly being revised and updated, including for use in different cultures, which requires continued validation efforts. Purpose The purpose of this study was to establish cross-cultural reliability and validity of the Technology-Rich Outcomes-Focused Learning Environment Inventory (TROFLEI) in both Turkey and the USA. Sample Approximately 980 students attending grades 9-12 in Turkey and 130 students attending grades 9-12 in the USA participated in the study. Design and method Scale reliability analyses and confirmatory factor analysis (CFA) were performed separately for Turkish and US participants for both actual and preferred responses to each scale to confirm the structure of the TROFLEI across these two distinct samples. Results Cronbach's alpha reliability coefficients, ranging from α = 0.820 to 0.931 for Turkish participants and from α = 0.778 to 0.939 for US participants, indicated that all scales have satisfactory internal consistency for both samples. Confirmatory factor analyses resulted in evidence of adequate model fit across both samples for both actual and preferred responses, with the root mean square error of approximation ranging from 0.052 to 0.057 and the comparative fit index ranging from 0.920 to 0.982. Conclusions This study provides initial evidence that the TROFLEI is valid for use in both the Turkish and US high-school populations (grades 9-12). However, the psychometric properties should be examined further with different populations, such as middle-school students (grades 6-8).

A Genome-Wide Knockout Screen to Identify Genes Involved in Acquired Carboplatin Resistance

DTIC Science & Technology

2016-07-01

library screen to identify genes that when knocked out render human ovarian cells > 2.5-fold resistant to CBDCA; 2) Validate the ability of...a GeCKOv2 library screen to identify genes that when knocked out render human ovarian cells > 2.5-fold resistant to CBDCA; 2) validate the ability of...resistance in either cell lines or clinical samples. The CRIPSR-cas9 technology now provides us with a major new tool to introduce knock out mutations

[Effects on cervical spondylosis of vertebral artery type and the concentrations of plasma NPY and UII in the patients treated with the modified acupuncture at unilateral/bilateral Renying (ST 9)].

PubMed

Wang, Yanfu; Ma, Chaoyang; Li, Lingxiao; Zhang, Ting; Gui, Xinghua; Chen, Hao

2018-05-12

To observe the differences in the clinical therapeutic effects on cervical spondylosis of vertebral artery type (CSA) between the modified acupuncture and the routine acupuncture at unilateral/bilateral Renying (ST 9) as well as the impacts on the concentrations of plasma neuropeptide Y (NPY) and urotensinⅡ(UⅡ) in the patients. A total of 160 patients were divided into a modified bilateral acupuncture group, a modified unilateral acupuncture group, a routine bilateral acupuncture group and a routine unilateral acupuncture group, 40 cases in each one according to the random number table. In the modified bilateral acupuncture group, the modified acupuncture was applied bilaterally to Renying (ST 9). In the modified unilateral acupuncture group, the modified acupuncture was applied unilaterally to Renying (ST 9). In the routine bilateral acupuncture group, the routine acupuncture was applied bilaterally to Renying (ST 9). In the routine unilateral acupuncture group, the routine acupuncture was applied unilaterally to Renying (ST 9). The treatment was given once every day, continuously for 6 days as one course. Two courses of treatment were required at the interval of 1 day. In each group, before and after treatment, we observed the peak systolic blood flow velocity (Vs) of the vertebral artery (VA) and the basilar artery (BA), cervical vertigo symptoms and functional assessment scales (ESCV) and the concentration of plasma NPY and UⅡ. The clinical therapeutic effects were compared among the groups. After treatment, the clinical therapeutic effect in the modified bilateral acupuncture group was 90.0% (36/40), which was better than 80.0% (32/40) in the modified unilateral acupuncture group, 77.5% (35/40) in the routine bilateral acupuncture group and 65.0% (26/40) in the routine unilateral acupuncture group (all P <0.05). After treatment, Vs of VA and BA was improved remarkably in every group (all P <0.01), and the result in the modified bilateral acupuncture group was higher than those in the other groups (all P <0.01). After treatment, ESCV scores were all increased remarkably in every group (all P <0.01). ESCV score and improvement index in the modified bilateral acupuncture group were all higher than those in the other groups ( P <0.05, P <0.01). After treatment, the concentrations of plasma NPY and UⅡ were all reduced remarkably in every group (all P <0.01) and the differences were significant among the groups (all P <0.01). The modified bilateral acupuncture at Renying (ST 9) effectively regulates the blood supply of the vertebral basilar artery and improves the cerebral circulation. The effects are superior to those of the unilateral acupuncture at Renying (ST 9).

What are Whole Exome Sequencing and Whole Genome Sequencing?

MedlinePlus

... the future. For more information about DNA sequencing technologies and their use: Genetics Home Reference discusses whether ... University in St. Louis describes the different sequencing technologies and what the new technologies have meant for ...

St. Lawrence Seaway : overview of safety, efficiency, operational, and environmental issues : discussion paper

DOT National Transportation Integrated Search

2017-04-01

This report is the first in a series of two reports focused on identifying opportunities for application of Intelligent Transportation System (ITS)technology or equivalent to address challenges and/or opportunities in the St. Lawrence Seaway....

"STL" Guiding the 21st Century Thinker

ERIC Educational Resources Information Center

Kelley, Todd R.

2014-01-01

Members of the technology and engineering education community have provided a clear message that (Standards for Technological Literacy) STL provides multiple opportunities to teach engineering concepts within K-12 education. This article will review recent research within technology education and the technological literacy standards…

Oral Challenge without Skin Testing Safely Excludes Clinically Significant Delayed-Onset Penicillin Hypersensitivity.

PubMed

Confino-Cohen, Ronit; Rosman, Yossi; Meir-Shafrir, Keren; Stauber, Tali; Lachover-Roth, Idit; Hershko, Alon; Goldberg, Arnon

Penicillins are the drug family most commonly associated with hypersensitivity reactions. Current guidelines recommend negative skin tests (ST) before re-administering penicillins to patients with previous nonimmediate reactions (NIR). The objective of this study was to examine whether ST are necessary before re-administering penicillin to patients with NIR. Patients with NIR to penicillins starting longer than 1 hour after last dose administration or starting any time after the first treatment day or patients with vague recollection of their reaction underwent penicillin ST. Disregarding ST results, patients were challenged with the relevant penicillins. One-tenth of the therapeutic dose followed by the full dose was administered at 1-hour interval and patients continued taking the full dose for 5 days. A total of 710 patients with alleged BL allergy were evaluated. Patients with a history of immediate reaction (52, 7.3%) or cephalosporin allergy (16, 2.2%) were excluded. Of the remaining 642 patients, 62.3% had negative ST, 5.3% positive ST, and 32.4% equivocal ST. A total of 617 (96.1%) patients were challenged. Immediate reaction was observed in 9 patients (1.5%): 1-positive ST, 7-negative ST, and 1-equivocal ST (P = .7). Late reaction to the first-day challenge occurred in 24 patients (4%). An at-home challenge was continued by 491 patients. Complete 5-day and partial challenges were well tolerated by 417 (85%) and 44 patients (8.9%), respectively, disregarding ST results. Thirty patients (6.1%) developed mild reactions to the home challenge regardless of their ST results. A 5-day oral challenge without preceding ST is safe and sufficient to exclude penicillin allergy after NIR developing during penicillin treatment. Copyright © 2017 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

A cut-off of daily sedentary time and all-cause mortality in adults: a meta-regression analysis involving more than 1 million participants.

PubMed

Ku, Po-Wen; Steptoe, Andrew; Liao, Yung; Hsueh, Ming-Chun; Chen, Li-Jung

2018-05-25

The appropriate limit to the amount of daily sedentary time (ST) required to minimize mortality is uncertain. This meta-analysis aimed to quantify the dose-response association between daily ST and all-cause mortality and to explore the cut-off point above which health is impaired in adults aged 18-64 years old. We also examined whether there are differences between studies using self-report ST and those with device-based ST. Prospective cohort studies providing effect estimates of daily ST (exposure) on all-cause mortality (outcome) were identified via MEDLINE, PubMed, Scopus, Web of Science, and Google Scholar databases until January 2018. Dose-response relationships between daily ST and all-cause mortality were examined using random-effects meta-regression models. Based on the pooled data for more than 1 million participants from 19 studies, the results showed a log-linear dose-response association between daily ST and all-cause mortality. Overall, more time spent in sedentary behaviors is associated with increased mortality risks. However, the method of measuring ST moderated the association between daily ST and mortality risk (p < 0.05). The cut-off of daily ST in studies with self-report ST was 7 h/day in comparison with 9 h/day for those with device-based ST. Higher amounts of daily ST are log-linearly associated with increased risk of all-cause mortality in adults. On the basis of a limited number of studies using device-based measures, the findings suggest that it may be appropriate to encourage adults to engage in less sedentary behaviors, with fewer than 9 h a day being relevant for all-cause mortality.

7 CFR Appendix A to Part 661 - Availability of Information

Code of Federal Regulations, 2010 CFR

2010-01-01

... Conservation Service, State Office Location State Conservationist, Wright Building, 138 South Gay St., P.O. Box..., Ariz. 85025. State Conservationist, Federal Bldg., Room 5029, 700 West Capitol St., P.O. Box 2323... Towers, Suite 2-4, 9 East Loockerman St., Dover, Del. 19901. State Conservationist, Federal Bldg., P.O...

Technology Leadership Conditions among Nebraska School Principals

ERIC Educational Resources Information Center

Curnyn, Molly A.

2013-01-01

As visionary leaders, school administrators are responsible for leading their schools into the 21st century by integrating technology to enhance learning and teaching. As technology leaders, principals must apply rigorous thought into the overall role that technology plays in the enhancement of student learning. Leveraging technology will assist…

Business Technology Education in the Early 21st Century: The Ongoing Quest for Relevance

ERIC Educational Resources Information Center

Andriole, Stephen J.

2006-01-01

The field of information technology is changing and those responsible for educating the next generation of technology professionals have responded with a new computing curriculum, which identifies five distinct technology majors: computer engineering, computer science, software engineering, information systems and information technology.…

Validity and Reliability of an on-Court Fitness Test for Assessing and Monitoring Aerobic Fitness in Squash.

PubMed

James, Carl Alexander; Vallejo, Florencio Tenllado; Kantebeen, Melvin; Farra, Saro

2018-02-14

Current on-court assessments of aerobic fitness in squash are not designed to yield a wealth of physiological data. Moreover, tests may require complex computer equipment or involve simulated racket strokes, which are difficult to standardize at high intensities. This study investigated the validity and reliability of a squash-specific fitness test which can yield both a standalone performance score, as well as pertinent physiological markers such as V[Combining Dot Above]O2max, the lactate turnpoint and oxygen cost, in a sport-specific environment. Eight national squash players completed three tests in a counter-balanced order; an incremental laboratory treadmill test (LAB) and two on-court fitness tests (ST) that involved repeated shuttle runs at increasing speeds. V[Combining Dot Above]O2max during ST was agreeable with LAB (Typical error [TE]=3.3 mL.kg.min, r=0.79). The mean bias between LAB and ST was 2.5 mL.kg.min. There were no differences in maximum heart rate, post exercise blood lactate concentration or end of test RPE between LAB and ST (p>0.05). The ST was highly reliable, with 74 (10) laps completed in ST1 and 75 (12) laps in ST2 (mean bias=1 lap, TE=3 laps, r=0.97). Physiological markers were also reliable, including V[Combining Dot Above]O2max, (TE=1.5 mL.kg.min, r=0.95), the lap number at 4 mMol (TE=4 laps, r=0.77) and average VO2 across the first 4 stages (TE=0.94 mL.kg.min, r=0.95). We observed good agreement between LAB and ST for assessing V[Combining Dot Above]O2max and between both on-court trials for assessing test performance and selected physiological markers. Consequently, we recommend this test for monitoring training adaptations and prescribing individualized training in elite squash players.

Using Technology in Helping Students Achieve 21st Century Skills: A Pilot Study

ERIC Educational Resources Information Center

Silvernail, David L.; Small, Dorothy; Walker, Leanne; Wilson, Richard L.; Wintle, Sarah E.

2008-01-01

As everyone enters the 21st Century there is a great deal of discussion in business and education circles alike about the type of skills the youth will need to survive and thrive in this century. At the same time, there is little known today about the level of 21st Century skills students currently have. In part this is because, as a nation,…

16-Lead ECG Changes with Coronary Angioplasty - Location of ST-T Changes with Balloon Occlusion of Five Arterial Perfusion Beds

DTIC Science & Technology

1991-08-01

Southeastern Center for Electrical Engineering REPORT NUMBER Education (SCEEE) 11th and Massachusetts Avenues St Cloud , FL 34769 D T |C 9. SPONSORING...performing the report. Self-explanatory. Enter U.S. Security Classification in accordance with U.S. Security Block 9. S Qonsorin/ Monitorig Aaencv

Draft genome sequences of 9 LA-MRSA ST5 isolates obtained from humans after short term swine contact

USDA-ARS?s Scientific Manuscript database

Livestock associated methicillin resistant Staphylococcus aureus (LA-MRSA) sequence type 5 have raised concerns surrounding the potential for these isolates to colonize or cause disease in humans with swine contact. Here, we report draft genome sequences for 9 LA-MRSA ST5 isolates obtained from huma...

A scale for assessing the severity of arousal disorders.

PubMed

Arnulf, Isabelle; Zhang, Bin; Uguccioni, Ginevra; Flamand, Mathilde; Noël de Fontréaux, Alix; Leu-Semenescu, Smaranda; Brion, Agnès

2014-01-01

Arousal disorders may have serious health consequences. To develop a scale assessing the severity of arousal disorders (Paris Arousal Disorders Severity Scale, PADSS). University hospital. Controlled study. Consecutive patients (older than 15 y), with sleepwalking (SW) and/or sleep terrors (ST), subjects with previous SW/ST, normal controls and patients with rapid eye movement sleep behavior disorder. The self-rated scale listed 17 parasomniac behaviors (PADSS-A), assessed their frequency from never to twice or more per night (PADSS-B) and evaluated the consequences (PADSS-C: disturbed sleep, injuries, fatigue, and psychological consequences). The clinimetric properties and face validity of the scale were tested. Half of the 73 patients with SW/ST (more men than women) had injured themselves or others, whereas 15% had concomitant sexsomnia and 23% had amnestic eating behaviors. The total PADSS score (range: 0-50) was 19.4 ± 6.3 (range: 8-36) in this group, 11.7 ± 5.9 in 26 subjects with previous SW/ST, 8.8 ± 3.2 in 26 patients with RBD, and 2.0 ± 3.5 in 53 normal controls (P < 0.05). The PADSS demonstrated high sensitivity (83.6%), specificity (87.8%), internal consistency, and test-retest reliability (0.79). The best cutoff for the total score was at 13/14. Exploratory factor analysis revealed two components: wandering and violence/handling. The complexity of behaviors emerging from N3 sleep (scored on videopolysomnography) positively correlated with scores for the PADSS-total, PADSS-A, PADSS-C, and the "violence/handling" factor. This scale had reasonable psychometric properties and could be used for screening and stratifying patients and for evaluating the effects of treatments.

Emergence of Carbapenemase Producing Klebsiella Pneumonia and Spread of KPC-2 and KPC-17 in Taiwan: A Nationwide Study from 2011 to 2013.

PubMed

Tseng, I-Ling; Liu, Yu-Mei; Wang, Shiow-Jen; Yeh, Hung-Yi; Hsieh, Chia-Lun; Lu, Hsueh-Lin; Tseng, Yu-Chuan; Mu, Jung-Jung

2015-01-01

The emergence of carbapenemase-producing Klebsiella pneumoniae (CPKP) has become a great concern worldwide. In this study, 994 non-duplicate, carbapenem non-susceptible Klebsiella pneumonia isolates were collected in Taiwan from 2011 to 2013 for detection of the carbapenemase genes, assessment of antimicrobial susceptibility and molecular epidemiology studies. Of these 994 isolates, 183 (18.4%) had carbapenemase genes: 157 (15.8%) KPC (145 KPC-2 and 12 KPC-17), 16 (1.6%) IMP-8, 9 (0.9%) VIM-1, and 1 (0.1%) NDM-1. KPC had the highest prevalence rate among the carbapenemases and represented a major epidemic clone circulating in Taiwan. The ST512 and ST258 KPC-2 KPs were first identified in Taiwan and were grouped into a small cluster in the PFGE profile. In addition, the genetic structure encompassing the blaKPC gene of the ST512 and ST258 isolates showed a different pattern from that of other KPC isolates. ST11 may be a major sequence type circulating in Taiwan, although a specific minor clone has begun to be observed. This is the first report of ST258 and ST512 KPC-2 KP isolates in Taiwan, whether ST258 and ST512 will become the next endemic problems in Taiwan should be closely monitored.

21st Century Youth Using Critical Thinking Skills and Practicing Cyber Safety When Making Digital Decisions: An Analysis of the Digital Devices and Decisions of Youth and Parental Perspectives of the Same

ERIC Educational Resources Information Center

Bryant, Veneschia R.

2013-01-01

The 21st century has allowed for endless possibilities in the areas of technology and technological innovations. Access is unlimited and society as a whole is benefiting from the abundance and availability, from private sectors to public. This access is truly tremendous as it continues to make many advances in areas such as medicine and education,…

Improving Student Achievement through Technology. Hearing before the Subcommittee on 21st Century Competitiveness of the Committee on Education and the Workforce. House of Representatives, One Hundred Seventh Congress, First Session (March 15, 2001).

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. House Committee on Education and the Workforce.

The Subcommittee on 21st Century Competitiveness, Committee on Education and the Workforce to met on Thursday, March 15, 2001 at 10:06 a.m., in Room 2175, Rayburn House Office Building, Hon. Howard P. "Buck" McKeon, Chairman of the Subcommittee presiding, to hear testimony on the use of technology to improve student achievement.Under…

Advances in the p and h-p Versions of the Finite Element Method. A survey

DTIC Science & Technology

1988-01-01

p versions is the code PROBE which was developed by NOETIC Technologies, St. Louis, MO [49] [60]. PROBE solves two dimensional problems of linear...p and h-p versions of the finite element method was studied in detail from various point of view. We will mention here some essential illustrative...49] PROBE - Sample Problems. Series of reports, Noetic Technologies, St. Louis, MO 63117. [50] Rank, E., Babu’ka, I., An expert system for the

Regularity of the Solution of Elliptic Problems with Piecewise Analytic Data. Part 1. Boundary Value Problems for Linear Ellilptic Equation of Second Order.

DTIC Science & Technology

1986-05-01

neighborhood of the Program PROBE of Noetic Technologies, St. Louis. corners of the domain, place where the type of the boundary condition changes, etc...is studied . , r ° -. o. - *- . ,. .- -*. ... - - . . . ’ , ..- , .- *- , . --s,." . ",-:, "j’ . ], k i-, j!3 ,, :,’ - .A L...Manual. Noetic Technologies Corp., St. Louis, Missouri (1985). 318] Szab’, B. A.: Implementation of a Finite Element Software System with h and p

Workshop Proceedings: Sensor Systems for Space Astrophysics in the 21st Century, Volume 2

NASA Technical Reports Server (NTRS)

Wilson, Barbara A. (Editor)

1991-01-01

In 1989, the Astrophysics Division of the Office of Space Science and Applications initiated the planning of a technology development program, Astrotech 21, to develop the technological base for the Astrophysics missions developed in the period 1995 to 2015. The Sensor Systems for Space Astrophysics in the 21st Century Workshop was one of three Integrated Technology Planning workshops. Its objectives were to develop an understanding of the future comprehensive development program to achieve the required capabilities. Program plans and recommendations were prepared in four areas: x ray and gamma ray sensors, ultraviolet and visible sensors, direct infrared sensors, and heterodyne submillimeter wave sensors.

2012 Missouri Local Technical Assistance Program (LTAP) at Missouri S&T.

DOT National Transportation Integrated Search

2013-05-01

This annual report is a summary of the activities during 2012 for the Missouri Local Technical : Assistance Program (Missouri LTAP), which is located at Missouri University of Science and : Technology (Missouri S&T). It is submitted to the Missouri D...

Aqueous two-phase system patterning of detection antibody solutions for cross-reaction-free multiplex ELISA

NASA Astrophysics Data System (ADS)

Frampton, John P.; White, Joshua B.; Simon, Arlyne B.; Tsuei, Michael; Paczesny, Sophie; Takayama, Shuichi

2014-05-01

Accurate disease diagnosis, patient stratification and biomarker validation require the analysis of multiple biomarkers. This paper describes cross-reactivity-free multiplexing of enzyme-linked immunosorbent assays (ELISAs) using aqueous two-phase systems (ATPSs) to confine detection antibodies at specific locations in fully aqueous environments. Antibody cross-reactions are eliminated because the detection antibody solutions are co-localized only to corresponding surface-immobilized capture antibody spots. This multiplexing technique is validated using plasma samples from allogeneic bone marrow recipients. Patients with acute graft versus host disease (GVHD), a common and serious condition associated with allogeneic bone marrow transplantation, display higher mean concentrations for four multiplexed biomarkers (HGF, elafin, ST2 and TNFR1) relative to healthy donors and transplant patients without GVHD. The antibody co-localization capability of this technology is particularly useful when using inherently cross-reactive reagents such as polyclonal antibodies, although monoclonal antibody cross-reactivity can also be reduced. Because ATPS-ELISA adapts readily available antibody reagents, plate materials and detection instruments, it should be easily transferable into other research and clinical settings.

Aqueous two-phase system patterning of detection antibody solutions for cross-reaction-free multiplex ELISA

PubMed Central

Frampton, John P.; White, Joshua B.; Simon, Arlyne B.; Tsuei, Michael; Paczesny, Sophie; Takayama, Shuichi

2014-01-01

Accurate disease diagnosis, patient stratification and biomarker validation require the analysis of multiple biomarkers. This paper describes cross-reactivity-free multiplexing of enzyme-linked immunosorbent assays (ELISAs) using aqueous two-phase systems (ATPSs) to confine detection antibodies at specific locations in fully aqueous environments. Antibody cross-reactions are eliminated because the detection antibody solutions are co-localized only to corresponding surface-immobilized capture antibody spots. This multiplexing technique is validated using plasma samples from allogeneic bone marrow recipients. Patients with acute graft versus host disease (GVHD), a common and serious condition associated with allogeneic bone marrow transplantation, display higher mean concentrations for four multiplexed biomarkers (HGF, elafin, ST2 and TNFR1) relative to healthy donors and transplant patients without GVHD. The antibody co-localization capability of this technology is particularly useful when using inherently cross-reactive reagents such as polyclonal antibodies, although monoclonal antibody cross-reactivity can also be reduced. Because ATPS-ELISA adapts readily available antibody reagents, plate materials and detection instruments, it should be easily transferable into other research and clinical settings. PMID:24786974

ST-segment resolution with bivalirudin versus heparin and routine glycoprotein IIb/IIIa inhibitors started in the ambulance in ST-segment elevation myocardial infarction patients transported for primary percutaneous coronary intervention: The EUROMAX ST-segment resolution substudy.

PubMed

Van't Hof, Arnoud; Giannini, Francesco; Ten Berg, Jurrien; Tolsma, Rudolf; Clemmensen, Peter; Bernstein, Debra; Coste, Pierre; Goldstein, Patrick; Zeymer, Uwe; Hamm, Christian; Deliargyris, Efthymios; Steg, Philippe G

2017-08-01

Myocardial reperfusion after primary percutaneous coronary intervention (PCI) can be assessed by the extent of post-procedural ST-segment resolution. The European Ambulance Acute Coronary Syndrome Angiography (EUROMAX) trial compared pre-hospital bivalirudin and pre-hospital heparin or enoxaparin with or without GPIIb/IIIa inhibitors (GPIs) in primary PCI. This nested substudy was performed in centres routinely using pre-hospital GPI in order to compare the impact of randomized treatments on ST-resolution after primary PCI. Residual cumulative ST-segment deviation on the single one hour post-procedure electrocardiogram (ECG) was assessed by an independent core laboratory and was the primary endpoint. It was calculated that 762 evaluable patients were needed to show non-inferiority (85% power, alpha 2.5%) between randomized treatments. A total of 871 participated with electrocardiographic data available in 824 patients (95%). Residual ST-segment deviation one hour after PCI was 3.8±4.9 mm versus 3.9±5.2 mm for bivalirudin and heparin+GPI, respectively ( p=0.0019 for non-inferiority). Overall, there were no differences between randomized treatments in any measures of ST-segment resolution either before or after the index procedure. Pre-hospital treatment with bivalirudin is non-inferior to pre-hospital heparin + GPI with regard to residual ST-segment deviation or ST-segment resolution, reflecting comparable myocardial reperfusion with the two strategies.

Salmonella enterica serovar typhimurium colonization of the crop in the domestic turkey: influence of probiotic and prebiotic treatment (Lactobacillus acidophilus and lactose).

PubMed

Johannsen, Sara A; Griffith, Ronald W; Wesley, Irene V; Scanes, Colin G

2004-01-01

Acute colonization of the crop of the domestic turkey by Salmonella enterica serovar typhimurium (ST) was examined. The influences of preharvest probiotic and prebiotic treatment with lactobaccilli and lactose on crop colonization with ST were also investigated. Prior to Salmonella challenge, poults received 2.5% lactose and Lactobacillus acidophilus (1.9 x 10(9) organisms/liter) in the only source of drinking water from 1 day old to termination. At 3-wk-old, turkey poults were challenged with ST (1.7 X 10(8) colony-forming units [CFU]/ml) before their natural nocturnal fast to determine the potential effects of supplementation on crop colonization when the crop was engorged and subsequently undergoing emptying. Crop ingesta and tissue were collected at time points 30 min and 4, 8, and 24 hr postchallenge and ST levels were determined. High levels of ST were detected in the crop. For instance, for the poults not receiving lactose or lactobacilli, 30 min after ST challenge, there were 4.4 x 10(7) CFU in the crop ingesta and 5.3 x 10(5) CFU in the crop wall. Ingesta ST levels dropped dramatically to 1.0 x 10(6) CFU after 4 hr as the crop emptied. Crop wall ST levels were steady during the nocturnal crop evacuation. Immunohistochemical staining demonstrated ST in close association with the crop epithelium. Treatment with lactose and L. acidophilus supplementation did not reduce ST colonization.

Factors that Predict Quality Classroom Technology Use

ERIC Educational Resources Information Center

Hastings, Tricia A.

2009-01-01

Despite technological advancements intended to enhance teaching and learning in the 21st century, numerous teacher and school factors continue to impede quality classroom technology use. Determining the effectiveness of educational technology is challenging and requires a detailed understanding of multifaceted, complex, contextual relationships.…

National Institute of Justice (NIJ): technology challenges

NASA Astrophysics Data System (ADS)

Morgan, John S.

2004-09-01

Law enforcement agencies play a key role in protecting the nation from and responding to terrorist attacks. The National Institute of Justice (NIJ) is the focal point for the research, development, test and evaluation of technology for law enforcement. NIJ and the Department of Homeland Security's Directorate of Science & Technology (DHS S&T) have related missions to support research and technology development for public safety. DHS S&T provides law enforcement agencies technology to respond to terrorist threats involving weapons of mass destruction, while NIJ focuses on technologies applicable across the spectrum of law enforcement needs. Investment in C3I technology offers perhaps the greatest potential benefit with respect to improving the ability to law enforcement agencies to respond to all types of crime including terrorist acts. Providing effective communications and information systems remains a key technology challenge, as does providing law enforcement responders accurate information that they can act on. Sensors and surveillance systems can play a key role in identifying terrorists and preventing or effectively responding to a terrorist attack.

Validation of the da Vinci Surgical Skill Simulator across three surgical disciplines: A pilot study

PubMed Central

Alzahrani, Tarek; Haddad, Richard; Alkhayal, Abdullah; Delisle, Josée; Drudi, Laura; Gotlieb, Walter; Fraser, Shannon; Bergman, Simon; Bladou, Frank; Andonian, Sero; Anidjar, Maurice

2013-01-01

Objective: In this paper, we evaluate face, content and construct validity of the da Vinci Surgical Skills Simulator (dVSSS) across 3 surgical disciplines. Methods: In total, 48 participants from urology, gynecology and general surgery participated in the study as novices (0 robotic cases performed), intermediates (1–74) or experts (≥75). Each participant completed 9 tasks (Peg board level 2, match board level 2, needle targeting, ring and rail level 2, dots and needles level 1, suture sponge level 2, energy dissection level 1, ring walk level 3 and tubes). The Mimic Technologies software scored each task from 0 (worst) to 100 (best) using several predetermined metrics. Face and content validity were evaluated by a questionnaire administered after task completion. Wilcoxon test was used to perform pair wise comparisons. Results: The expert group comprised of 6 attending surgeons. The intermediate group included 4 attending surgeons, 3 fellows and 5 residents. The novices included 1 attending surgeon, 1 fellow, 13 residents, 13 medical students and 2 research assistants. The median number of robotic cases performed by experts and intermediates were 250 and 9, respectively. The median overall realistic score (face validity) was 8/10. Experts rated the usefulness of the simulator as a training tool for residents (content validity) as 8.5/10. For construct validity, experts outperformed novices in all 9 tasks (p < 0.05). Intermediates outperformed novices in 7 of 9 tasks (p < 0.05); there were no significant differences in the energy dissection and ring walk tasks. Finally, experts scored significantly better than intermediates in only 3 of 9 tasks (matchboard, dots and needles and energy dissection) (p < 0.05). Conclusions: This study confirms the face, content and construct validities of the dVSSS across urology, gynecology and general surgery. Larger sample size and more complex tasks are needed to further differentiate intermediates from experts. PMID:23914275

10 CFR Appendix A to Part 835 - Derived Air Concentrations (DAC) for Controlling Radiation Exposure to Workers at DOE Facilities

Code of Federal Regulations, 2014 CFR

2014-01-01

.../ET Na-22 2 E−07 - - 1 E+04 - - E// Na-24 4 E−07 - - 1 E+04 - - ET// Mg-28 3 E−07 3 E−07 - 1 E+04 1 E+04 - ET/St/ Al-26 4 E−08 4 E−08 - 1 E+03 1 E+03 - St/St/ Si-31 9 E−06 5 E−06 5 E−06 3 E+05 1 E+05 1 E+05 ET/St/St Si-32 1 E−07 5 E−08 1 E−08 5 E+03 2 E+03 3 E+02 St/St/St P-32 5 E−07 1 E−07 - 1 E+04 7 E...

10 CFR Appendix A to Part 835 - Derived Air Concentrations (DAC) for Controlling Radiation Exposure to Workers at DOE Facilities

Code of Federal Regulations, 2013 CFR

2013-01-01

.../ET Na-22 2 E−07 - - 1 E+04 - - E// Na-24 4 E−07 - - 1 E+04 - - ET// Mg-28 3 E−07 3 E−07 - 1 E+04 1 E+04 - ET/St/ Al-26 4 E−08 4 E−08 - 1 E+03 1 E+03 - St/St/ Si-31 9 E−06 5 E−06 5 E−06 3 E+05 1 E+05 1 E+05 ET/St/St Si-32 1 E−07 5 E−08 1 E−08 5 E+03 2 E+03 3 E+02 St/St/St P-32 5 E−07 1 E−07 - 1 E+04 7 E...

10 CFR Appendix A to Part 835 - Derived Air Concentrations (DAC) for Controlling Radiation Exposure to Workers at DOE Facilities

Code of Federal Regulations, 2012 CFR

2012-01-01

.../ET Na-22 2 E−07 - - 1 E+04 - - E// Na-24 4 E−07 - - 1 E+04 - - ET// Mg-28 3 E−07 3 E−07 - 1 E+04 1 E+04 - ET/St/ Al-26 4 E−08 4 E−08 - 1 E+03 1 E+03 - St/St/ Si-31 9 E−06 5 E−06 5 E−06 3 E+05 1 E+05 1 E+05 ET/St/St Si-32 1 E−07 5 E−08 1 E−08 5 E+03 2 E+03 3 E+02 St/St/St P-32 5 E−07 1 E−07 - 1 E+04 7 E...

The Effect of Schinus terebinthifolius Raddi (Anacardiaceae) Bark Extract on Histamine-Induced Paw Edema and Ileum Smooth Muscle Contraction.

PubMed

Nunes-Neto, Paulo Alexandre; Peixoto-Sobrinho, Tadeu José da Silva; da Silva Júnior, Edilson Dantas; Leopoldina da Silva, Jamilka; Rodrigo da Silva Oliveira, Alisson; Pupo, André Sampaio; Araújo, Alice Valença; da Costa-Silva, João Henrique; Wanderley, Almir Gonçalves

2017-01-01

Schinus terebinthifolius Raddi (Anacardiaceae), popularly known as red aroeira, is used in traditional medicine to treat inflammatory, gastric, and respiratory disorders. The aim of this study was to evaluate the antihistaminic activity of S. terebinthifolius (St) bark extract by using in vivo and in vitro experimental models. The effects of St were investigated on contractions induced by histamine, carbachol, and potassium chloride in isolated guinea pig ileum. St was also studied in response to hind paw edema induced by histamine in rats. Experiments revealed that although St (250, 500, and 1,000  µ g/mL) reduced the histamine-induced contractions by 9.1 ± 1.8, 50.2 ± 2.0, and 68.9 ± 2.0%, respectively, it did not inhibit contractions induced by carbachol or KCl. The association of St (250 and 500  µ g/mL) with hydroxyzine, an H 1 -antihistamine (0.125 and 0.250  µ M), increased the inhibitory effect to 67.0 ± 3.2 and 85.1 ± 2.1%, respectively. Moreover, St (100, 200, and 400 mg/kg) decreased paw edema from its peak by 33.9, 48.4, and 54.8%, respectively, whereas hydroxyzine (70 mg/kg) inhibited the peak edema by 56.5%. Altogether, the results suggest that the bark extract of S. terebinthifolius has an antihistaminic effect (H 1 ).

The Effect of Schinus terebinthifolius Raddi (Anacardiaceae) Bark Extract on Histamine-Induced Paw Edema and Ileum Smooth Muscle Contraction

PubMed Central

Nunes-Neto, Paulo Alexandre; da Silva Júnior, Edilson Dantas; Leopoldina da Silva, Jamilka; Rodrigo da Silva Oliveira, Alisson; Pupo, André Sampaio; Araújo, Alice Valença

2017-01-01

Schinus terebinthifolius Raddi (Anacardiaceae), popularly known as red aroeira, is used in traditional medicine to treat inflammatory, gastric, and respiratory disorders. The aim of this study was to evaluate the antihistaminic activity of S. terebinthifolius (St) bark extract by using in vivo and in vitro experimental models. The effects of St were investigated on contractions induced by histamine, carbachol, and potassium chloride in isolated guinea pig ileum. St was also studied in response to hind paw edema induced by histamine in rats. Experiments revealed that although St (250, 500, and 1,000 µg/mL) reduced the histamine-induced contractions by 9.1 ± 1.8, 50.2 ± 2.0, and 68.9 ± 2.0%, respectively, it did not inhibit contractions induced by carbachol or KCl. The association of St (250 and 500 µg/mL) with hydroxyzine, an H1-antihistamine (0.125 and 0.250 µM), increased the inhibitory effect to 67.0 ± 3.2 and 85.1 ± 2.1%, respectively. Moreover, St (100, 200, and 400 mg/kg) decreased paw edema from its peak by 33.9, 48.4, and 54.8%, respectively, whereas hydroxyzine (70 mg/kg) inhibited the peak edema by 56.5%. Altogether, the results suggest that the bark extract of S. terebinthifolius has an antihistaminic effect (H1). PMID:28928787

Perspectives on Validation of High-Throughput Assays Supporting 21st Century Toxicity Testing

EPA Science Inventory

In vitro high-throughput screening (HTS) assays are seeing increasing use in toxicity testing. HTS assays can simultaneously test many chemicals but have seen limited use in the regulatory arena, in part because of the need to undergo rigorous, time-consuming formal validation. ...

The GEOSS Science and Technology Stakeholder Network and Service Suite: Linking S&T Communities and GEOSS

NASA Astrophysics Data System (ADS)

Plag, Hans-Peter; Jules-Plag, Shelley

2015-04-01

The Global Earth Observation System of Systems (GEOSS) developed by the Group on Earth Observations (GEO) aims to provide practice-relevant knowledge in support of decision making in a wide range of societal benefit areas. Generating this practice-relevant knowledge based on Earth observations, socio-economic data and models often depends on research, and utilization of the societal benefits of EOs requires the involvement of science and research communities. Building a GEOSS responding to the needs of a wide range of users necessitates contributions from many science and technology (S&T) communities. In particular, a strong engagement of science and technology (S&T) communities in both the development and use of GEOSS is necessary to address the complex issues associated with the on-going transition out of the Holocene. S&T support is needed to improve interoperability between global observing, modeling, and information systems; to enable data integration across disciplinary boundaries; to facilitate data sharing, archiving, dissemination, and reanalysis; to optimize the recording of observations, assimilation of data into models, and generation of data products; to enhance the value of observations from individual observing systems through their integration in the SBAs; and to harmonize well-calibrated, highly accurate, stable, sustained in-situ and satellite observations of the same variable recorded by different sensors and different agencies. Consequently, the GEO Work Plan includes several Tasks focusing on outreach to S&T communities, and most of the GEO Community of Practice have a strong S&T component. The GEOSS S&T Stakeholder Network facilitates input from S&T communities to GEO. Infrastructure serving and linking S&T users communities and GEOSS has been developed and is integrated into a GEOSS S&T Service Suite (GSTSS). The GSTSS has several outreach components for the demonstration of GEOSS and its value for S&T communities, and for services supporting S&T communities in their linkage to, and use of GEOSS. At the core of the GSTSS, the GEOSS S&T Portfolio includes examples showing GEOSS at work for S&T communities and provides an avenue for S&T groups to feature their contribution to GEOSS. The assessment of datasets is supported through an extensive feedback system. The User Requirements Registry (URR) allows users to publish what they do, how they do it, and what information and observations they need to do it. The URR is currently transitioned into a Socio-Economic and Environmental Information Needs Knowledge Base (SEE IN KB), which focuses on the linkage between societal goals and benefits on the one side and essential earth observations on the other side. The S&T Meeting Web Portal provides a workspace to coordinate and document GEO and GEOSS participation, side events, and presentations at relevant S&T meetings. The GEOSS S&T Stakeholder Network provides an umbrella for all S&T user and provider communities. The idea of a Stakeholder Network bringing together relevant S&T communities was developed by the EC-funded EGIDA project, and the underlying concept assumes that successful outreach to S&T communities requires demonstration of a benefit for these communities. The mission of the GEOSS S&T Stakeholder Network is twofold: to provide a voice for the needs and guidance of S&T communities to GEO, and to promote the use of GEOSS in these stakeholder communities. Workshops of the GEOSS S&T Stakeholder Network are organized within the GSTSS, among others with the goal to link societal goals, such as the Millennium Development Goals and the Sustainable Development Goals, and associated targets to a metric that then can be tied to essential variables to be provided by GEOSS.

A Scale Development for 21st Century Skills of Primary School Students: A Validity and Reliability Study

ERIC Educational Resources Information Center

Boyaci, S. Dilek Belet; Atalay, Nurhan

2016-01-01

The objective of the present study is to develop a measurement tool to assess 21st Century learning and innovation skills of primary school students. Study data was collected from 632 fourth grade students in five different primary schools during 2014-2015 academic year and data obtained from 609 fourth grade students were utilized in the study.…

If F(ST) does not measure neutral genetic differentiation, then comparing it with Q(ST) is misleading. Or is it?

PubMed

Edelaar, Pim; Björklund, Mats

2011-05-01

The comparison between neutral genetic differentiation (F(ST) ) and quantitative genetic differentiation (Q(ST) ) is commonly used to test for signatures of selection in population divergence. However, there is an ongoing discussion about what F(ST) actually measures, even resulting in some alternative metrics to express neutral genetic differentiation. If there is a problem with F(ST) , this could have repercussions for its comparison with Q(ST) as well. We show that as the mutation rate of the neutral marker increases, F(ST) decreases: a higher within-population heterozygosity (He) yields a lower F(ST) value. However, the same is true for Q(ST) : a higher mutation rate for the underlying QTL also results in a lower Q(ST) estimate. The effect of mutation rate is equivalent in Q(ST) and F(ST) . Hence, the comparison between Q(ST) and F(ST) remains valid, if one uses neutral markers whose mutation rates are not too high compared to those of quantitative traits. Usage of highly variable neutral markers such as hypervariable microsatellites can lead to serious biases and the incorrect inference that divergent selection has acted on populations. Much of the discussion on F(ST) seems to stem from the misunderstanding that it measures the differentiation of populations, whereas it actually measures the fixation of alleles. In their capacity as measures of population differentiation, Hedrick's G'(ST) and Jost's D reach their maximum value of 1 when populations do not share alleles even when there remains variation within populations, which invalidates them for comparisons with Q(ST) . © 2011 Blackwell Publishing Ltd.

Impact of inhospital stent thrombosis and cerebrovascular accidents on long-term prognosis after percutaneous coronary intervention.

PubMed

Guerra, Elena; Ndrepepa, Gjin; Schulz, Stefanie; Byrne, Robert; Hoppmann, Petra; Kufner, Sebastian; Ibrahim, Tareq; Tada, Tomohisa; Schunkert, Heribert; Laugwitz, Karl-Ludwig; Kastrati, Adnan

2014-12-01

Inhospital stent thrombosis (ST) and cerebrovascular accidents (CVA) are rare but serious adverse events after percutaneous coronary intervention (PCI). The association of ST or CVA with long-term outcome after PCI remains poorly investigated. The study included 18,334 consecutive patients who underwent PCI. Patients were divided into 3 groups: the group with ST, the group with CVA, and the group without these events. The primary outcome was all-cause mortality at 3-year follow-up. Inhospital ST or CVA occurred in 59 patients (0.32%) and in 90 patients (0. 49%), respectively. There were 2,149 deaths (11.7%) during the follow-up: 26 deaths among patients with ST, 32 deaths among patients with CVA, and 2,091 deaths among patients without ST or CVA (Kaplan-Meier estimates of 3-year mortality 45.3%, 38.0%, and 12.9%, odds ratio 6.1, 95% CI 3.6-10.2, P < .001 for ST group vs the group without ST or CVA and odds ratio 4.2 [2.7-6.6], P < .001 for CVA group vs the group without ST or CVA). There was no significant difference in the 3-year mortality between CVA and ST groups (P = .29). The Cox proportional hazards model showed that ST (adjusted hazard ratio 4.97, 95% CI 2.58-9.56, P < .001) and CVA (adjusted hazard ratio 2.25 [1.25-4.04], P = .006) were independently associated with the increased risk of 3-year mortality. Inhospital ST and CVA after PCI are associated with the increased risk of 3-year mortality. Both events seem to have a similar impact on long-term survival. Copyright © 2014 Elsevier Inc. All rights reserved.

Manufacturing Methods and Technology Program Plan, CY 1983,

DTIC Science & Technology

1983-09-01

vehicles will fill the need for an armored ": vehicle that can be moved rapidly and fight effectively in nearly any contingency area. Experience ...00000D0000 0 0 U. 00ODO CO~ 00 00 OD DO O O DODO CID OD00 O 00 U OD 1 CI C tO O wn > LL) U, 0. 0w Lnn 0 0 8- V)ᝰ a z. -5Jw .DF - U,8z 9 8 - 58 t 3> z 30...Readiness Command -" ATTN: DRSTS-PLE, Mr. Don G. Doll 4300 Goodfellow Blvd. C: 314 263-2218 St. Louis, MO 63120 AV: 693-2218 Cl q 4 MERADCOH US Army

NASA-UVA Light Aerospace Alloy and Structures Technology Program (LA2ST)

NASA Technical Reports Server (NTRS)

Gangloff, Richard P.; Starke, Edgar A., Jr.; Kelly, Robert G.; Scully, John R.; Shiflet, Gary J.; Stoner, Glenn E.; Wert, John A.

1997-01-01

The NASA-UVA Light Aerospace Alloy and Structures Technology (LA2ST) Program was initiated in 1986 and continues with a high level of activity. Here, we report on progress achieved between July I and December 31, 1996. The objective of the LA2ST Program is to conduct interdisciplinary graduate student research on the performance of next generation, light-weight aerospace alloys, composites and thermal gradient structures in collaboration with NASA-Langley researchers. Specific technical objectives are presented for each research project. We generally aim to produce relevant data and basic understanding of material mechanical response, environmental/corrosion behavior, and microstructure; new monolithic and composite alloys; advanced processing methods; new solid and fluid mechanics analyses; measurement and modeling advances; and a pool of educated graduate students for aerospace technologies. The accomplishments presented in this report are summarized as follows. Three research areas are being actively investigated, including: (1) Mechanical and Environmental Degradation Mechanisms in Advanced Light Metals, (2) Aerospace Materials Science, and (3) Mechanics of Materials for Light Aerospace Structures.

NASA-UVA light aerospace alloy and structures technology program (LA2ST)

NASA Technical Reports Server (NTRS)

Starke, Edgar A., Jr.; Gangloff, Richard P.; Herakovich, Carl T.; Scully, John R.; Shiflet, Gary J.; Stoner, Glenn E.; Wert, John A.

1995-01-01

The NASA-UVa Light Aerospace Alloy and Structures Technology (LA2ST) Program was initiated in 1986 and continues with a high level of activity. Projects are being conducted by graduate students and faculty advisors in the Department of Materials Science and Engineering, as well as in the Department of Civil Engineering and Applied Mechanics, at the University of Virginia. Here, we report on progress achieved between July 1 and December 31, 1994. The objective of the LA2ST Program is to conduct interdisciplinary graduate student research on the performance of next generation, light-weight aerospace alloys, composites and thermal gradient structures in collaboration with NASA-Langley researchers. Specific technical objectives are presented for each research project. We generally aim to produce relevant data and basic understanding of material mechanical response, environmental/corrosion behavior, and microstructure; new monolithic and composite alloys; advanced processing methods; new solid and fluid mechanics analyses; measurement and modeling advances; and a pool of educated graduate students for aerospace technologies.

NASA-UVA Light Aerospace Alloy and Structures Technology Program: LA(2)ST

NASA Technical Reports Server (NTRS)

Gangloff, Richard P.; Haviland, John K.; Herakovich, Carl T.; Pilkey, Walter D.; Pindera, Marek-Jerzy; Scully, John R.; Stoner, Glenn E.; Thornton, Earl A.; Wawner, Franklin E., Jr.; Wert, John A.

1993-01-01

The NASA-UVA Light Aerospace Alloy and Structures Technology (LA(2)ST) Program continues a high level of activity, with projects being conducted by graduate students and faculty advisors in the Departments of Materials Science and Engineering, Civil Engineering and Applied Mechanics, and Mechanical and Aerospace Engineering at the University of Virginia. This work is funded by the NASA-Langley Research Center under Grant NAG-1-745. We report on progress achieved between July 1 and December 31, 1992. The objective of the LA(2)ST Program is to conduct interdisciplinary graduate student research on the performance of next generation, light weight aerospace alloys, composites and thermal gradient structures in collaboration with NASA-Langley researchers. Specific technical objectives are presented for each research project. We generally aim to produce relevant data and basic understanding of material mechanical response, corrosion behavior, and microstructure; new monolithic and composite alloys; advanced processing methods; new solid and fluid mechanics analyses; measurement advances; and critically, a pool of educated graduate students for aerospace technologies.

Molecular Epidemiologic Analysis of Enterococcus faecalis Isolates in Cuba by Multilocus Sequence Typing

PubMed Central

Kobayashi, Nobumichi; Nagashima, Shigeo

2009-01-01

We carried out the first study of Enterococcus faecalis clinical isolates in Cuba by multilocus sequence typing linking the molecular typing data with the presence of virulence determinants and the antibiotic resistance genes. A total of 23 E. faecalis isolates recovered from several clinic sources and geographic areas of Cuba during a period between 2000 and 2005 were typed by multilocus sequence typing. Thirteen sequence types (STs) including five novel STs were identified, and the ST 64 (clonal complex [CC] 8), ST 6 (CC2), ST 21(CC21), and ST 16 (CC58) were found in more than one strain. Sixty-seven percent of STs corresponded to STs reported previously in Spain, Poland, and The Netherlands, and other STs (ST115, ST64, ST6, and ST40) were genetically close to those detected in the United States. Prevalence of both antimicrobial resistance genes [aac(6′)-aph(2″), aph(3′), ant(6), ant(3″)(9), aph(2″)-Id, aph(2″)-Ic, erm(B), erm(A), erm(C), mef(A), tet(M), and tet(L)] and virulence genes (agg, gelE, cylA, esp, ccf, and efaAfs) were examined by polymerase chain reaction. Aminoglycoside resistance genes aac(6′)-Ie-aph(2″)-Ia, aph(3′), ant(6), ant(3″)(9) were more frequently detected in ST6, ST16, ST23, ST64, and ST115. The multidrug resistance was distributed to all STs detected, except for ST117 and singleton ST225. The presence of cyl gene was specifically linked to the ST64 and ST16. Presence of the esp, gel, and agg genes was not specific to any particular ST. This research provided the first insight into the population structure of E. faecalis in Cuba, that is, most Cuban strains were related to European strains, whereas others to U.S. strains. The CC2, CC21, and CC8, three of the biggest CCs in the world, were evidently circulating in Cuba, associated with multidrug resistance and virulence traits. PMID:19857135

76 FR 10341 - Notice of Intent To Grant Partially Exclusive Patent License; Dakota Technologies, Inc.

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-24

..., 53560 Hull St., Bldg. A33 Room 2305, San Diego, CA 92152-5001. FOR FURTHER INFORMATION CONTACT: Brian..., Code 72120, 53560 Hull St., Bldg. A33 Room 2305, San Diego, CA 92152-5001, telephone 619-553-5118, E...

The Symbiotic Relationship of Science and Technology in the 21st Century.

ERIC Educational Resources Information Center

Wiens, A. Emerson

1999-01-01

There are many examples in which science and technology complement each other. This is especially evident in biotechnology and genetic engineering. This symbiotic relationship is foundational to the technological culture of contemporary society. (SK)

SITE - DEMONSTRATION BULLETIN - MINERGY GLASS FURNACE TECHNOLOGY - MINERGY CORPORATION

EPA Science Inventory

The Glass Furnace Technology (GFT) was developed by Minergy Corporation (Minergy), of Waukesha, Wisconsin. Minergy originally developed vitrification technologies to process wastewater sludge into glass aggregate that could be sold as a commercial product. Minergy modified a st...

Authentic Instruction and Technology Literacy

ERIC Educational Resources Information Center

Cydis, Susan

2015-01-01

Technology integration is an important aspect of student competence in the 21st century. The use of technology in teaching and learning is a valuable practice for supporting student learning and engagement. Modelling the pedagogical practices that integrate authentic, performance-based opportunities for technology integration was the focus of a…

We will make you like our research: The development of a susceptibility-to-persuasion scale

PubMed Central

Modic, David; Anderson, Ross

2018-01-01

Psychological and other persuasive mechanisms across diverse contexts are well researched, with many studies of the effectiveness of specific persuasive techniques on distinct types of human behaviour. In the present paper, our specific interest lies in the development of a generalized modular psychometric tool to measure individuals’ susceptibility to persuasion. The scale is constructed using items from previously developed and validated particulate scales established in the domains of social psychology and behavioural economics. In the first study we establish the Susceptibility to Persuasion–II (StP-II) scale, containing 54 items, 10 subscales and further 6 sub-sub scales. In Study 2 we establish the scale’s construct validity and reconfirm its reliability. We present a valid and reliable modular psychometric tool that measures general susceptibility to persuasive techniques. Since its inception, we have successfully implemented the StP-II scale to measure susceptibility to persuasion of IT security officers, the role of psychology of persuasion in cybercrime victims and general persuadability levels of Facebook users; these manuscripts are in preparation. We argue that the StP-II scale shows promise in measuring individual differences in susceptibility to persuasion, and is applicable across diverse contexts such as Internet security and cybercrime. PMID:29543845

The descriptive epidemiology of total physical activity, muscle-strengthening exercises and sedentary behaviour among Australian adults--results from the National Nutrition and Physical Activity Survey.

PubMed

Bennie, Jason A; Pedisic, Zeljko; van Uffelen, Jannique G Z; Gale, Joanne; Banting, Lauren K; Vergeer, Ineke; Stamatakis, Emmanuel; Bauman, Adrian E; Biddle, Stuart J H

2016-01-25

The current Australia's Physical Activity and Sedentary Behaviour Guidelines recommend that adults engage in regular moderate-to-vigorous-intensity physical activity (MVPA) and strength training (ST), and minimise time spent in sedentary behaviours (SB). However, evidence about the specific individual and concurrent distribution of these behaviours in Australia is scarce. Therefore, the aim of this study was to determine the prevalence and sociodemographic correlates of MVPA, ST and SB in a national-representative sample of Australian adults. Data were collected using face-to-face interviews, as part of the National Nutrition and Physical Activity Survey 2011-12. The population-weighted proportions meeting the MVPA (≥ 150 min/week), ST (≥ 2 sessions/week) and combined MVPA-ST guidelines, and proportions classified as having 'low levels of SB' (< 480 min/day) were calculated, and their associations with selected sociodemographic and health-related variables were assessed using multiple logistic regression analyses. This was also done for those at potentially 'high-risk', defined as insufficient MVPA-ST and 'high-sedentary' behaviour. Out of 9345 participants (response rate = 77.0 %), aged 18-85 years, 52.6 % (95 % CI: 51.2 %-54.0 %), 18.6 % (95 % CI: 17.5 %-19.7 %) and 15.0 % (95 % CI: 13.9 %-16.1 %) met the MVPA, ST and combined MVPA-ST guidelines, respectively. Female gender, older age, low/medium education, poorer self-rated health, being classified as underweight or obese, and being a current smoker were independently associated with lower odds of meeting the MVPA, ST and combined MVPA-ST guidelines. A total of 78.9 % (95 % CI: 77.9 %-80.0 %) were classified as having low levels of SB. Females, older adults and those with lower education were more likely to report lower levels of SB, whilst those with poor self-rated health and obese individuals were less likely to report lower levels of SB (i.e. SB = ≥ 480 min/day). A total of 8.9 % (95 % CI: 8.1 %-9.6 %) were categorised as individuals at potentially 'high-risk'. Those with poorer self-rated health, obese individuals, those aged 25-44, and current smokers were more likely to be in the 'high risk' group. The large majority of Australian adults do not meet the full physical activity guidelines and/or report excessive SB. Our results call for public health interventions to reduce physical inactivity and SB in Australia, particularly among the subgroups at the highest risk of these unhealthy behaviours.

Empowering School Teachers for Emerging Technologies: An Action Plan

ERIC Educational Resources Information Center

Misra, Pradeep Kumar

2010-01-01

"Possessing openness to emerging technologies is critical for teachers in the technology-rich 21st Century as technology continues to accelerate at a rapid rate. Readiness for new technologies is a challenge associated with change. Teachers who resist change may impede and/or limit their students' learning and skills. Teachers, therefore,…

Using Technology in Gifted and Talented Education Classrooms: The Teachers' Perspective

ERIC Educational Resources Information Center

Zimlich, Susan L.

2015-01-01

Technology skills are assumed to be a necessity for college and career success, but technology is constantly evolving. Thus, development of students' technology skills is an on-going and persistent issue. Standards from the Partnership for 21st Century Skills and the International Society for Technology in Education encourage educators to teach…

The Model Technology School: Toward Literacy through Technology. Technology.

ERIC Educational Resources Information Center

Schneider, Raymond J.

This paper describes one Florida school's experience with the Model Technology Schools (MTS) pilot program, and proposes a poetry curriculum for K-12 education that incorporates laserdisc technology for student presentations. Webster Elementary School in St. Augustine was the smallest of five schools chosen for the MTS program to demonstrate the…

Publications - GMC 50 | Alaska Division of Geological & Geophysical Surveys

Science.gov Websites

DGGS GMC 50 Publication Details Title: Palynological analysis of core chips from the Mobil Oil Corporation Mikkelsen Bay State #13-9-19, Humble Oil East Mikkelsen Bay State #1, Mobil Oil Corporation West Staines St. #18-9-23 and the Exxon Alaska St. A-1 wells Authors: Marshall, Thomas, Union Oil Company of

Clinical Objective Dry Eye Tests in a Population of Tannery Workers in North India.

PubMed

Ranjan, Ratnesh; Kushwaha, Raj Nath; Khan, Perwez; Mohan, Shalini; Gupta, Ramesh Chandra

2016-10-01

To analyze the correlation between subjective symptoms and clinical signs of dry eye among tannery workers. In this cross-sectional study, three classic clinical tests, namely the fluorescein tear film break-up time (FTBUT) test, the fluorescein staining (FS) test, and the Schirmer test (ST), were performed to assess the clinical signs of dry eye disease in 246 tanners who were found symptomatic for dry eye in a prior ocular surface disease index survey. All workers were male with a mean age of 35 ± 9 years, and the mean duration of work at tanneries was 8 ± 5 years. Among 246 symptomatic subjects, the FTBUT test, the FS test and the ST were positive in 63.8%, 30.9% and 41.9% workers, respectively. Mean FTBUT and ST scores were 10.6 ± 4.2 seconds and 10.1 ± 7.7mm, respectively. Mean FTBUT for mild, moderate and severe symptom categories differed significantly. Mean ST scores for the mild symptom group were significantly higher than that of the moderate group (p < 0.0001). The FTBUT and ST score showed a strong negative correlation with severity of symptoms (p < 0.0001). A moderate positive correlation was observed between FS positivity and increasing symptom severity (p < 0.0001). The effect of age was insignificant for FTBUT (p = 0.10), while significant for ST score (p < 0.001). The effect of duration of tannery work was significant for both FTBUT and ST scores (p < 0.0001). Clinical tests correlated well with symptom severity among tanners, and a multifactorial etiology is suggested for dry eye diseases.

Physicochemical analysis and adequation of olive oil mill wastewater after advanced oxidation process for reclamation by pressure-driven membrane technology.

PubMed

Ochando-Pulido, Javier Miguel; Victor-Ortega, Maria Dolores; Hodaifa, Gassan; Martinez-Ferez, Antonio

2015-01-15

Physicochemical characterization of olive mill wastewaters (OMW) was studied after a primary and secondary treatment was implemented in an olive oil factory in Jaén (Spain), comprising natural precipitation, Fenton-like reaction, flocculation-sedimentation and olive stone filtration in series. The application of membrane technology in improving the quality of the secondary-treated OMW (OMW/ST) was examined, to reduce the hazardous electroconductivity (EC) values (2-3 mS cm(-1)). Particle size distribution on OMW/ST shows supra-micron colloids and suspended solids as well as sub-micron particles with a mean size below 1.5 μm remaining in considerable concentration. The high organic pollutants percentage (31.7%) registered with an average diameter below 3 kDa is sensibly relevant for membrane fouling. Mesophilic aerobic bacteria growth warns of possible membrane biofouling formation. The saturation index indicates to work upon recovery factor below 90%. Finally, operating at a pressure equal to 15 bar ensured low fouling and high flux production on the selected NF membrane (69.9 L h(-1)m(-2)) and significant rejection efficiencies (55.5% and 88.5% for EC and COD). This permits obtaining an effluent with good quality according to the recommendations of the Food and Agricultural Association (FAO) with the goal of reusing the regenerated water for irrigation. Copyright © 2014 Elsevier B.V. All rights reserved.

Office of Science and Technology&International Year EndReport - 2005

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bodvarsson, G.S.

2005-10-27

Source Term, Materials Performance, Radionuclide Getters, Natural Barriers, and Advanced Technologies, a brief introduction in each section describes the overall organization and goals of each program area. All of these areas have great potential for improving our understanding of the safety performance of the proposed Yucca Mountain repository, as processes within these areas are generally very conservatively represented in the Total System Performance Assessment. In addition, some of the technology thrust areas in particular may enhance system efficiency and reduce risk to workers. Thus, rather modest effort in the S&T Program could lead to large savings in the lifetime repositorymore » total cost and significantly enhanced understanding of the behavior of the proposed Yucca Mountain repository, without safety being compromised, and in some instances being enhanced. An overall strength of the S&T Program is the significant amount of integration that has already been achieved after two years of research. As an example (illustrated in Figure 1), our understanding of the behavior of the total waste isolation system has been enhanced through integration of the Source Term, Materials Performance, and Natural Barriers Thrust areas. All three thrust areas contribute to the integration of different processes in the in-drift environment. These processes include seepage into the drift, dust accumulation on the waste package, brine formation and precipitation on the waste package, mass transfer through the fuel cladding, changes in the seepage-water chemical composition, and transport of released radionuclides through the invert and natural barriers. During FY2005, each of our program areas assembled a team of external experts to conduct an independent review of their respective projects, research directions, and emphasis. In addition, the S&T Program as a whole was independently reviewed by the S&T Programmatic Evaluation Panel. As a result of these reviews, adjustments to the S&T Program will be implemented in FY2006 to ensure that the Program is properly aligned with OCRWM's priorities. Also during FY2005, several programmatic documents were published, including the Science and Technology Program Strategic Plan, the Science and Technology Program Management Plan, and the Science and Technology Program Plan. These and other communication products are available on the OCRWM web site under the Science and Technology section (http://www.ocrwm.doe.gov/osti/index.shtml).« less

Experimental asthma persists in IL-33 receptor knockout mice because of the emergence of thymic stromal lymphopoietin-driven IL-9+ and IL-13+ type 2 innate lymphoid cell subpopulations.

PubMed

Verma, Mukesh; Liu, Sucai; Michalec, Lidia; Sripada, Anand; Gorska, Magdalena M; Alam, Rafeul

2017-11-10

IL-33 plays an important role in the development of experimental asthma. We sought to study the role of the IL-33 receptor suppressor of tumorigenicity 2 (ST2) in the persistence of asthma in a mouse model. We studied allergen-induced experimental asthma in ST2 knockout (KO) and wild-type control mice. We measured airway hyperresponsiveness by using flexiVent; inflammatory indices by using ELISA, histology, and real-time PCR; and type 2 innate lymphoid cells (ILC2s) in lung single-cell preparations by using flow cytometry. Airway hyperresponsiveness was increased in allergen-treated ST2 KO mice and comparable with that in allergen-treated wild-type control mice. Peribronchial and perivascular inflammation and mucus production were largely similar in both groups. Persistence of experimental asthma in ST2 KO mice was associated with an increase in levels of thymic stromal lymphopoietin (TSLP), IL-9, and IL-13, but not IL-5, in bronchoalveolar lavage fluid. Expectedly, ST2 deletion caused a reduction in IL-13 + CD4 T cells, forkhead box P3-positive regulatory T cells, and IL-5 + ILC2s. Unexpectedly, ST2 deletion led to an overall increase in innate lymphoid cells (CD45 + lin - CD25 + cells) and IL-13 + ILC2s, emergence of a TSLP receptor-positive IL-9 + ILC2 population, and an increase in intraepithelial mast cell numbers in the lung. An anti-TSLP antibody abrogated airway hyperresponsiveness, inflammation, and mucus production in allergen-treated ST2 KO mice. It also caused a reduction in innate lymphoid cell, ILC2, and IL-9 + and IL-13 + ILC2 numbers in the lung. Genetic deletion of the IL-33 receptor paradoxically increases TSLP production, which stimulates the emergence of IL-9 + and IL-13 + ILC2s and mast cells and leads to development of chronic experimental asthma. An anti-TSLP antibody abrogates all pathologic features of asthma in this model. Copyright © 2017 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Characterisation of nasal Staphylococcus delphini and Staphylococcus pseudintermedius isolates from healthy donkeys in Tunisia.

PubMed

Gharsa, H; Slama, K Ben; Gómez-Sanz, E; Gómez, P; Klibi, N; Zarazaga, M; Boudabous, A; Torres, C

2015-07-01

Staphylococcus intermedius group (SIG) bacteria can colonise the nares of some animals but are also emerging pathogens in humans and animals. To analyse SIG nasal carriage in healthy donkeys destined for food consumption in Tunisia and to characterise recovered isolates. Nasal swabs from 100 healthy donkeys were tested for SIG recovery, and isolates were identified by biochemical and molecular methods. Antimicrobial susceptibility of isolates was tested and detection of antimicrobial resistance and virulence genes was performed. Isolates were typed at the clonal level by multilocus sequence typing and SmaI pulsed-field gel electrophoresis. Staphylococcus delphini and Staphylococcus pseudintermedius (included in SIG) were obtained in 19% and 2% of the tested samples, respectively, and one isolate per sample was characterised. All isolates were meticillin susceptible and mecA negative. Most S. delphini and S. pseudintermedius isolates showed susceptibility to all antimicrobials tested, with the exception of 2 isolates resistant to tetracycline (tet(M) gene) or fusidic acid. The following toxin genes were identified (percentage of isolates): lukS-I (100%), lukF-I (9.5%), siet (100%), se-int (90%), seccanine (19%) and expA (9.5%). Thirteen different pulsed-field gel electrophoresis profiles were identified among the 21 SIG isolates. Additionally, the following 9 different sequence types (STs) were detected by multilocus sequence typing, 6 of them new: ST219 (6 isolates), ST12 (5 isolates), ST220 (3 isolates), ST13, ST50, ST193, ST196, ST218 and ST221 (one isolate each). Staphylococcus delphini and S. pseudintermedius are common nasal colonisers of donkeys, generally susceptible to the antimicrobials tested; nevertheless, these SIG isolates contain virulence genes, including the recently described exfoliative gene (expA) and several enterotoxin genes, with potential implications for public health. This is the first description of S. delphini in Tunisia. The Summary is available in Chinese - see Supporting information. © 2014 EVJ Ltd.

IL-33 and soluble ST2 levels as novel predictors for remission and progression of carotid plaque in early rheumatoid arthritis: A prospective study.

PubMed

Shen, Jiayun; Shang, Qing; Wong, Chun-Kwok; Li, Edmund K; Wang, Shang; Li, Rui-Jie; Lee, Ka-Lai; Leung, Ying-Ying; Ying, King-Yee; Yim, Cheuk-Wan; Kun, Emily W; Leung, Moon-Ho; Li, Martin; Li, Tena K; Zhu, Tracy Y; Yu, Shui-Lian; Kuan, Woon-Pang; Yu, Cheuk-Man; Tam, Lai-Shan

2015-08-01

To study the association between the baseline IL-33 and soluble ST2 (sST2) levels with disease remission and progression of carotid atherosclerosis in early rheumatoid arthritis (ERA) patients. A total of 98 ERA patients were enrolled. Disease activity and the presence of carotid plaque were evaluated at baseline and 12 months later. Plasma IL-33 and sST2 levels were determined using enzyme-linked immunosorbent assay kits. Baseline IL-33 and sST2 levels were associated with inflammatory markers and cardiovascular (CV) risk factors. Overall, 44(45%), 18(18%), and 21(21%) patients achieved remission based on 28-joint disease activity score (DAS28), Boolean, and simplified disease activity score (SDAI) criteria at 12 months, respectively. Patients with detectable IL-33 at baseline were less likely to achieve DAS28 (P = 0.010) and SDAI remission (P = 0.021), while a lower baseline sST2 level was able to predict DAS28, Boolean, and SDAI remission (P = 0.005, 0.001, and <0.001, respectively). Using multivariate analysis, a lower baseline sST2 level independently predict Boolean (OR = 0.789; P = 0.005) and SDAI remission (0.812; P = 0.008). Regarding carotid atherosclerosis, 9/98(9.2%) patients had plaque progression at 12 months. Baseline IL-33 was detectable in 8/9(89%) and 42/83(51%) of patients with and without plaque progression respectively (P = 0.029). Baseline detectable IL-33 was an independent predictor for plaque progression after adjusting for traditional CV risk factors (P = 0.017). Lower baseline sST2 levels independently predict disease remission and baseline detectable IL-33 independently predicts carotid plaque progression in ERA patients. This study suggests that inflammation induced by the IL-33/ST2 axis may play a significant role in the development of cardiovascular disease in RA. Copyright © 2015 Elsevier Inc. All rights reserved.

Utilisation, Reliability and Validity of Clinical Evaluation Exercise in Otolaryngology Training.

PubMed

Awad, Z; Hayden, L; Muthuswamy, K; Tolley, N S

2015-10-01

To investigate the utilisation, reliability and validity of clinical evaluation exercise (CEX) in otolaryngology training. Retrospective database analysis. Online assessment database. We analysed all CEXs submitted by north London core (CT) and speciality trainees (ST) in otolaryngology from 2010 to 2013. Internal consistency of the 7 CEX items rated as either O: outstanding, S: satisfactory or D: development required. Overall performance rating (pS) of 1-4 assessed against completion of training level. Receiver operating characteristic was used to describe CEX sensitivity and specificity. Overall score (cS), pS and the number of 'D'-rated items were used to investigate construct validity. One thousand one hundred and sixty CEXs from 45 trainees were included. CEX showed good internal consistency (Cronbach's alpha= 0.85). CEX was highly sensitive (99%), yet not specific (6%). cS and pS for ST was higher than CT (99.1% ± 0.4 versus 96.6% ± 0.8 and 3.06 ± 0.05 versus 1.92 ± 0.04, respectively P < 0.001). pS showed a significant stepwise increase from CT1 to ST6 (P < 0.001). In contrast, cS only showed improvement up to ST4 (P = 0.025). The most frequently utilised item 'management and follow-up planning' was found to be the best predictor of cS and pS (rs  = +0.69 and +0.21, respectively). CEX is reliable in assessing early years otolaryngology trainees in clinical examination, but not at higher level. It has the potential to be used in a summative capacity in selecting trainees for ST positions. This would also encourage trainees to master all domains of otolaryngology clinical examination by end of CT. © 2015 John Wiley & Sons Ltd.

Face and Construct Validation of a Virtual Peg Transfer Simulator

PubMed Central

Arikatla, Venkata S; Sankaranarayanan, Ganesh; Ahn, Woojin; Chellali, Amine; De, Suvranu; Caroline, GL; Hwabejire, John; DeMoya, Marc; Schwaitzberg, Steven; Jones, Daniel B.

2013-01-01

Background The Fundamentals of Laparascopic Surgery (FLS) trainer box is now established as a standard for evaluating minimally invasive surgical skills. A particularly simple task in this trainer box is the peg transfer task which is aimed at testing the surgeon’s bimanual dexterity, hand-eye coordination, speed and precision. The Virtual Basic Laparoscopic Skill Trainer (VBLaST©) is a virtual version of the FLS tasks which allows automatic scoring and real time, subjective quantification of performance without the need of a human proctor. In this paper we report validation studies of the VBLaST© peg transfer (VBLaST-PT©) simulator. Methods Thirty-five subjects with medical background were divided into two groups: experts (PGY 4-5, fellows and practicing surgeons) and novices (PGY 1-3). The subjects were asked to perform the peg transfer task on both the FLS trainer box and the VBLaST-PT© simulator and their performance was evaluated based on established metrics of error and time. A new length of trajectory (LOT) metric has also been introduced for offline analysis. A questionnaire was used to rate the realism of the virtual system on a 5-point Likert scale. Results Preliminary face validation of the VBLaST-PT© with 34 subjects rated on a 5-point Likert scale questionnaire revealed high scores for all aspects of simulation, with 3.53 being the lowest mean score across all questions. A two-tailed Mann-Whitney performed on the total scores showed significant (p=0.001) difference between the groups. A similar test performed on the task time (p=0.002) and the length of trajectory (p=0.004) separately showed statistically significant differences between the experts and novice groups (p<0.05). The experts appear to be traversing shorter overall trajectories in less time than the novices. Conclusion VBLaST-PT© showed both face and construct validity and has promise as a substitute for the FLS to training peg transfer skills. PMID:23263645

S007--Preliminary Evaluation of the Pattern Cutting and the Ligating Loop Virtual Laparoscopic Trainers

PubMed Central

Chellali, A.; Ahn, W.; Sankaranarayanan, G.; Flinn, J. T.; Schwaitzberg, S. D.; Jones, D.B.; De, Suvranu; Cao, C.G.L.

2014-01-01

Introduction The Fundamentals of Laparoscopic Surgery (FLS) trainer is currently the standard for training and evaluating basic laparoscopic skills. However, its manual scoring system is time-consuming and subjective. The Virtual Basic Laparoscopic Skill Trainer (VBLaST©) is the virtual version of the FLS trainer which allows automatic and real time assessment of skill performance, as well as force feedback. In this study, the VBLaST© pattern cutting (VBLaST-PC©) and ligating loop (VBLaST-LL©) tasks were evaluated as part of a validation study. We hypothesized that performance would be similar on the FLS and VBLaST© trainers, and that subjects with more experience would perform better than those with less experience on both trainers. Methods Fifty-five subjects with varying surgical experience were recruited at the Learning Center during the 2013 SAGES annual meeting and were divided into two groups: experts (PGY 5, surgical fellows and surgical attendings) and novices (PGY 1–4). They were asked to perform the pattern cutting or the ligating loop task on the FLS and the VBLaST© trainers. Their performance scores for each trainer were calculated and compared. Results There were no significant differences between the FLS and VBLaST© scores for either the pattern cutting or the ligating loop task. Experts’ scores were significantly higher than the scores for novices on both trainers. Conclusion This study showed that the subjects’ performance on the VBLaST© trainer was similar to the FLS performance for both tasks. Both the VBLaST-PC© and the VBLaST-LL© tasks permitted discrimination between the novice and expert groups. Though concurrent and discriminant validity has been established, further studies to establish convergent and predictive validity are needed. Once validated as a training system for laparoscopic skills, the system is expected to overcome the current limitations of the FLS trainer. PMID:25159626

NASA-UVA Light Aerospace Alloy and Structures Technology Program (LA2ST)

NASA Technical Reports Server (NTRS)

Gangloff, Richard P.

1994-01-01

The NASA-UVA Light Aerospace Alloy and Structures Technology (LA2ST) Program was initiated in 1986 and continues with a high level of activity. Projects are being conducted by graduate students and faculty advisors in the Department of Materials Science and Engineering, as well as in the Department of Civil Engineering and Applied Mechanics, at the University of Virginia. This work is funded by the NASA-Langley Research Center under Grant NAG-1-745. Here, we report on progress achieved between January 1 and June 30, 1994. These results were presented at the Fifth Annual NASA LA2ST Grant Review Meeting held at the Langley Research Center in July of 1994. The objective of the LA2ST Program is to conduct interdisciplinary graduate student research on the performance of next generation, lightweight aerospace alloys, composites, and thermal gradient structures in collaboration with NASA-Langley researchers. Specific technical objectives are presented for each research project. We generally aim to produce relevant data and basic understanding of material mechanical response, environmental/corrosion behavior, and microstructure; new monolithic and composite alloys; advanced processing methods; new solid and fluid mechanics analyses; measurement and modeling advances; and a pool of educated graduate students for aerospace technologies.

Integrating Renewable Energy into the Transmission and Distribution System of the U. S. Virgin Islands

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burman, K.; Olis, D.; Gevorgian, V.

2011-09-01

This report focuses on the economic and technical feasibility of integrating renewable energy technologies into the U.S. Virgin Islands transmission and distribution systems. The report includes three main areas of analysis: 1) the economics of deploying utility-scale renewable energy technologies on St. Thomas/St. John and St. Croix; 2) potential sites for installing roof- and ground-mount PV systems and wind turbines and the impact renewable generation will have on the electrical subtransmission and distribution infrastructure, and 3) the feasibility of a 100- to 200-megawatt power interconnection of the Puerto Rico Electric Power Authority (PREPA), Virgin Islands Water and Power Authority (WAPA),more » and British Virgin Islands (BVI) grids via a submarine cable system.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Xiaoqi; Yao, Lei; Xi, Lei

Purpose: To evaluate the feasibility of functional photoacoustic tomography (fPAT) for high resolution detection and characterization of breast cancer and to demonstrate for the first time quantitative hemoglobin concentration and oxygen saturation images of breasts that were formed with model-based reconstruction of tomographic photoacoustic data. Methods: The study was HIPAA compliant and was approved by the university institutional review board. Written informed consents were obtained from all the participants. Ten cases, including six cancer and four healthy (mean age = 50 yr; age range = 41–66 yr), were examined. Functional images of breast tissue including absolute total hemoglobin concentration (Hb{submore » T}) and oxygen saturation (StO{sub 2}%) were obtained by fPAT and cross validated with magnetic resonance imaging (MRI) readings and/or histopathology. Results: Hb{sub T} and StO{sub 2}% maps from all six pathology-confirmed cancer cases (60%) show clear detection of tumor, while MR images indicate clear detection of tumor for five of six cancer cases; one small tumor was read as near-complete-resolution by MRI. The average Hb{sub T} and StO{sub 2}% value of suspicious lesion area for the cancer cases was 61.6 ± 18.9 μM/l and 67.5% ± 5.2% compared to 25.6 ± 7.4 μM/l and 65.2% ± 3.8% for background normal tissue. Conclusions: fPAT has the potential to be a significant add-on in breast cancer detection and characterization as it provides submillimeter resolution functional images of breast lesions.« less