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Sample records for standards laboratory center

  1. Sandia National Laboratories Facilities Management and Operations Center Design Standards Manual

    SciTech Connect

    Peterson, Timothy L.

    2014-09-01

    At Sandia National Laboratories in New Mexico (SNL/NM), the design, construction, operation, and maintenance of facilities is guided by industry standards, a graded approach, and the systematic analysis of life cycle benefits received for costs incurred. The design of the physical plant must ensure that the facilities are "fit for use," and provide conditions that effectively, efficiently, and safely support current and future mission needs. In addition, SNL/NM applies sustainable design principles, using an integrated whole-building design approach, from site planning to facility design, construction, and operation to ensure building resource efficiency and the health and productivity of occupants. The safety and health of the workforce and the public, any possible effects on the environment, and compliance with building codes take precedence over project issues, such as performance, cost, and schedule. These design standards generally apply to all disciplines on all SNL/NM projects. Architectural and engineering design must be both functional and cost-effective. Facility design must be tailored to fit its intended function, while emphasizing low-maintenance, energy-efficient, and energy-conscious design. Design facilities that can be maintained easily, with readily accessible equipment areas, low maintenance, and quality systems. To promote an orderly and efficient appearance, architectural features of new facilities must complement and enhance the existing architecture at the site. As an Architectural and Engineering (A/E) professional, you must advise the Project Manager when this approach is prohibitively expensive. You are encouraged to use professional judgment and ingenuity to produce a coordinated interdisciplinary design that is cost-effective, easily contractible or buildable, high-performing, aesthetically pleasing, and compliant with applicable building codes. Close coordination and development of civil, landscape, structural, architectural, fire

  2. Primary Standards Laboratory report

    SciTech Connect

    Not Available

    1990-12-01

    Sandia National Laboratories operates the Primary Standards Laboratory (PSL) for the Department of Energy, Albuquerque Operations Office (DOE/AL). This report summarizes metrology activities that received emphasis in the first half of 1990 and provides information pertinent to the operation of the DOE/AL system-wide Standards and Calibration Program.

  3. Standards Laboratory environments

    SciTech Connect

    Braudaway, D.W.

    1990-09-01

    Standards Laboratory environments need to be carefully selected to meet the specific mission of each laboratory. The mission of the laboratory depends on the specific work supported, the measurement disciplines required and the level of uncertainty required in the measurements. This document reproduces the contents of the Sandia National Laboratories Primary Standards Laboratory Memorandum Number 3B (PSLM-3B) which was issued on May 16, 1988, under the auspices of the Department of Energy, Albuquerque Operations Office, to guide the laboratories of the Nuclear Weapons Complex in selecting suitable environments. Because of both general interest and specific interest in Standards Laboratory environments this document is being issued in a more available form. The purpose of this document is to provide guidance in selection of laboratory environments suitable for standards maintenance and calibration operations. It is not intended to mandate a specific environment for a specific calibration but to direct selection of the environment and to offer suggestions on how to extend precision in an existing and/or achievable (practical) environment. Although this documents pertains specifically to standards laboratories, it can be applied to any laboratory requiring environmental control.

  4. Sonication standard laboratory module

    DOEpatents

    Beugelsdijk, Tony; Hollen, Robert M.; Erkkila, Tracy H.; Bronisz, Lawrence E.; Roybal, Jeffrey E.; Clark, Michael Leon

    1999-01-01

    A standard laboratory module for automatically producing a solution of cominants from a soil sample. A sonication tip agitates a solution containing the soil sample in a beaker while a stepper motor rotates the sample. An aspirator tube, connected to a vacuum, draws the upper layer of solution from the beaker through a filter and into another beaker. This beaker can thereafter be removed for analysis of the solution. The standard laboratory module encloses an embedded controller providing process control, status feedback information and maintenance procedures for the equipment and operations within the standard laboratory module.

  5. Standards for laboratory accreditation.

    PubMed

    1982-12-01

    After years of review by all of the CAP resource and other committees and councils, the Commission on Laboratory Accreditation developed a revised Standards for Accreditation of Medical Laboratories (Last revision, 1974). They were approved by the House of Delegates and, in the February issue of Pathologist '82, comments were solicited from the entire membership. Presented in the following pages are the final Standards for Laboratory Accreditation, which the Board of Governors adopted as CAP policy at its Sept. 2-4 meeting in Traverse City, Mich.

  6. Dental Laboratory Technology Program Standards.

    ERIC Educational Resources Information Center

    Georgia Univ., Athens. Dept. of Vocational Education.

    This guide contains 45 program standards for the dental laboratory technology program conducted in technical institutes in Georgia. The dental laboratory technology program, either diploma or associate degree, is designed to ensure that students gain basic competence in the job skills needed for an entry-level employee in dental laboratory…

  7. [Quality standards for medical laboratories].

    PubMed

    Pascal, P; Beyerle, F

    2006-07-01

    In France, medical laboratories must engage a quality approach according to the standard guide de bonne exécution des analyses (GBEA) and, for hospital laboratories, according to the Agence nationale d'évaluation en santé (Anaes). Except the GBEA and the Anaes handbook, which are obligatory standards by regulations, the biologists can choose, for a complementary and voluntary quality process, between the standards ISO 9001, ISO 17025 or ISO 15189. Our aim is to shed light on the advantages of these five standards by realizing a comparative study of their requirements. This work enabled us to highlight a great number of similarities and to raise the characteristics of these five standards. According to their objectives, the biologists will choose a recognition of their quality management system with an ISO 9001 certification or a recognition extended to the technical skills with an ISO 17025 or ISO 15189 accreditation. The contents of these last two documents are rather close and both integrate requirements of the standard ISO 9001. The standard ISO 17025 is, at first sight, rather distant from the biological analysis, requiring many efforts of adaptation, just like the ISO 9001 standard. The standard ISO 15189 seems to be well adapted but more constraining seeing the details requirements level needed. It necessitates a perfect control of the preanalytical phase, which is difficult to acquire in a clinical framework where the biological fluids are not taken by the laboratory staff.

  8. Argonne's Laboratory computing center - 2007 annual report.

    SciTech Connect

    Bair, R.; Pieper, G. W.

    2008-05-28

    Argonne National Laboratory founded the Laboratory Computing Resource Center (LCRC) in the spring of 2002 to help meet pressing program needs for computational modeling, simulation, and analysis. The guiding mission is to provide critical computing resources that accelerate the development of high-performance computing expertise, applications, and computations to meet the Laboratory's challenging science and engineering missions. In September 2002 the LCRC deployed a 350-node computing cluster from Linux NetworX to address Laboratory needs for mid-range supercomputing. This cluster, named 'Jazz', achieved over a teraflop of computing power (1012 floating-point calculations per second) on standard tests, making it the Laboratory's first terascale computing system and one of the 50 fastest computers in the world at the time. Jazz was made available to early users in November 2002 while the system was undergoing development and configuration. In April 2003, Jazz was officially made available for production operation. Since then, the Jazz user community has grown steadily. By the end of fiscal year 2007, there were over 60 active projects representing a wide cross-section of Laboratory expertise, including work in biosciences, chemistry, climate, computer science, engineering applications, environmental science, geoscience, information science, materials science, mathematics, nanoscience, nuclear engineering, and physics. Most important, many projects have achieved results that would have been unobtainable without such a computing resource. The LCRC continues to foster growth in the computational science and engineering capability and quality at the Laboratory. Specific goals include expansion of the use of Jazz to new disciplines and Laboratory initiatives, teaming with Laboratory infrastructure providers to offer more scientific data management capabilities, expanding Argonne staff use of national computing facilities, and improving the scientific reach and

  9. Research Laboratories and Centers Fact Sheet

    EPA Pesticide Factsheets

    The Office of Research and Development is the research arm of the U.S. Environmental Protection Agency. It has three national laboratories and four national centers located in 14 facilities across the country.

  10. OSHA Laboratory Standard: Driving Force for Laboratory Safety!

    ERIC Educational Resources Information Center

    Roy, Kenneth R.

    2000-01-01

    Discusses the Occupational Safety and Health Administration's (OSHA's) Laboratory Safety Standards as the major driving force in establishing and maintaining a safe working environment for teachers and students. (Author)

  11. Metals Processing Laboratory User Center (MPLUS)

    SciTech Connect

    Mackiewicz-Ludtka, G.; Hayden, H.W.

    1997-04-01

    The Metals Processing Laboratory User (MPLUS) Center was officially designated as a DOE User Facility in February, 1996. It`s primary purpose is to assist researchers in key U.S. industries, universities, and federal laboratories in improving energy efficiency and enhancing U.S. competitiveness in the world market. The MPLUS Center provides users the unique opportunity to address technology-related issues to solve metals-processing problems from a fully integrated approach. DOE facilitates the process and catalyzes industrial interactions that enables technical synergy and financial leveraging to take place between the industrial sector identifying and prioritizing their technological needs, and MPLUS, which provides access to the technical expertise and specialized facilities to address these needs. MPLUS is designed to provide U.S. industries with access to the specialized technical expertise and equipment needed to solve metals-processing issues that limit the development and implementation of emerging metals-processing technologies. As originated, MPLUS includes the following four primary user centers: Metals Processing, Metals Joining, Metals Characterization, and Metals Process Modeling. These centers are devoted to assisting U.S. industries in adjusting to rapid changes in the marketplace and in improving products and processes. This approach optimizes the complementary strengths of industry and government. Tremendous industrial response, has resulted in MPLUS expanding to meet the ever-growing technical needs and requests initiated by U.S. industry.

  12. Standardization of terminology in laboratory medicine II.

    PubMed

    Lee, Kap No; Yoon, Jong-Hyun; Min, Won Ki; Lim, Hwan Sub; Song, Junghan; Chae, Seok Lae; Jang, Seongsoo; Ki, Chang-Seok; Bae, Sook Young; Kim, Jang Su; Kwon, Jung-Ah; Lee, Chang Kyu; Yoon, Soo-Young

    2008-08-01

    Standardization of medical terminology is essential in data transmission between health care institutes and in maximizing the benefits of information technology. The purpose of this study was to standardize medical terms for laboratory observations. During the second year of the study, a standard database of concept names for laboratory terms that covered those used in tertiary health care institutes and reference laboratories was developed. The laboratory terms in the Logical Observation Identifier Names and Codes (LOINC) database were adopted and matched with the electronic data interchange (EDI) codes in Korea. A public hearing and a workshop for clinical pathologists were held to collect the opinions of experts. The Korean standard laboratory terminology database containing six axial concept names, components, property, time aspect, system (specimen), scale type, and method type, was established for 29,340 test observations. Short names and mapping tables for EDI codes and UMLS were added. Synonym tables were prepared to help match concept names to common terms used in the fields. We herein described the Korean standard laboratory terminology database for test names, result description terms, and result units encompassing most of the laboratory tests in Korea.

  13. Challenges of implementing Iranian national laboratory standards.

    PubMed

    Safadel, N; Dahim, P; Anjarani, S; Rahnamaye Farzami, M; Samiee, S Mirab; Amini, R; Farsi, Sh; Mahdavi, S; Khodaverdian, K; Rashed Marandi, F

    2013-01-01

    After four years of publishing the Iranian National Laboratory Standard and following a strategic plan to implement its requirements, it was decided to review the taken actions, evaluating the achievements and the failures, as well as analyzing the gaps and planning the interventional activities to resolve the problems. A thorough evaluation revealed that the progress of implementation process varies considerably in different provinces, as well as in laboratories in different public and private sectors. Diversity and heterogeneousity of laboratories throughout the country is one of unresolvable problems. Although we encounter shortage of resources in the country, improper allocation or distribution of resources and budgets make the problems more complicated. Inadequacy of academic training in laboratory sciences has resulted in necessity of holding comprehensive post-graduate training courses. Revising academic curriculum of laboratory sciences could be mostly helpful, moreover there should be organized, training courses with pre-determined practical topics. providing specific technical guidelines, to clarify the required technical details could temporarily fill the training gaps of laboratory staff. Inadequate number of competent auditors was one of the difficulties in universities. Another important challenge returns to laboratory equipment, developing the national controlling system to manage the laboratory equipment in terms of quality and accessibility has been planned in RHL. At last cultural problems and resistance to change are main obstacles that have reduced the pace of standardization, it needs to rationalize the necessity of establishing laboratory standards for all stakeholders.

  14. Certification standards transfer: from committee to laboratory.

    PubMed

    Lehmann, H P

    1998-12-01

    The ISO 9000 Standards series were developed to provide the international manufacturing industry with a framework to ensure purchased products meet quality criteria. Section 4 of ISO 9001, Quality System Model for Quality Assurance in Design, Development, Production, Installation and Servicing, contains 20 aspects of a quality system that must be addressed by an organization in order to receive ISO 9001 certification. This concept is extended to the clinical laboratory, where a quality system program establishes for the customer (patient/clinician) that the purchased product (requested information on a submitted specimen-test result) meets established quality norms. In order to satisfy the customer, the providing organization must have policies and procedures in place that ensure a quality product, and be certified. To become certified the organization must, through an inspection process, demonstrate to an independent accrediting agency that it meets defined standards. In the United States, the government through the Clinical Laboratory Improvement Amendment (CLIA) 1988 established quality standards for the clinical laboratory. The College of American Pathologists (CAP), through its Laboratory Accreditation Program (LAP), serves as an independent agency that certifies that laboratories meet standards. To demonstrate the applicability of an established clinical laboratory accreditation program to ISO 9001 certification, the standards and checklists of CLIA 1988 and the CAP LAP will be examined to determine their conformance to ISO 9001, Section 4.

  15. Technical activities 1986, Center for Basic Standards

    NASA Astrophysics Data System (ADS)

    Heydemann, P. L. M.

    1986-10-01

    The report summarizes the research and technical activities of the Center for Basic Standards during the Fiscal Year 1986. These activities include work in the areas of electricity, temperature and pressure, mass and length, time and frequency, quantum metrology, and quantum physics.

  16. Argonne's Laboratory computing resource center : 2006 annual report.

    SciTech Connect

    Bair, R. B.; Kaushik, D. K.; Riley, K. R.; Valdes, J. V.; Drugan, C. D.; Pieper, G. P.

    2007-05-31

    Argonne National Laboratory founded the Laboratory Computing Resource Center (LCRC) in the spring of 2002 to help meet pressing program needs for computational modeling, simulation, and analysis. The guiding mission is to provide critical computing resources that accelerate the development of high-performance computing expertise, applications, and computations to meet the Laboratory's challenging science and engineering missions. In September 2002 the LCRC deployed a 350-node computing cluster from Linux NetworX to address Laboratory needs for mid-range supercomputing. This cluster, named 'Jazz', achieved over a teraflop of computing power (10{sup 12} floating-point calculations per second) on standard tests, making it the Laboratory's first terascale computing system and one of the 50 fastest computers in the world at the time. Jazz was made available to early users in November 2002 while the system was undergoing development and configuration. In April 2003, Jazz was officially made available for production operation. Since then, the Jazz user community has grown steadily. By the end of fiscal year 2006, there were 76 active projects on Jazz involving over 380 scientists and engineers. These projects represent a wide cross-section of Laboratory expertise, including work in biosciences, chemistry, climate, computer science, engineering applications, environmental science, geoscience, information science, materials science, mathematics, nanoscience, nuclear engineering, and physics. Most important, many projects have achieved results that would have been unobtainable without such a computing resource. The LCRC continues to foster growth in the computational science and engineering capability and quality at the Laboratory. Specific goals include expansion of the use of Jazz to new disciplines and Laboratory initiatives, teaming with Laboratory infrastructure providers to offer more scientific data management capabilities, expanding Argonne staff use of national

  17. Temporary Laboratory Office in Huntsville Industrial Center Building

    NASA Technical Reports Server (NTRS)

    1964-01-01

    Temporary quarters in the Huntsville Industrial Center (HIC) building located in downtown Huntsville, Alabama, as Marshall Space Flight Center (MSFC) grew. This image shows drafting specialists from the Propulsion and Vehicle Engineering Laboratory at work in the HIC building.

  18. Standardizing clinical laboratory data for secondary use

    PubMed Central

    Demner-Fushman, Dina; McDonald, Clement J.

    2012-01-01

    Clinical databases provide a rich source of data for answering clinical research questions. However, the variables recorded in clinical data systems are often identified by local, idiosyncratic, and sometimes redundant and/or ambiguous names (or codes) rather than unique, well-organized codes from standard code systems. This reality discourages research use of such databases, because researchers must invest considerable time in cleaning up the data before they can ask their first research question. Researchers at MIT developed MIMIC-II, a nearly complete collection of clinical data about intensive care patients. Because its data are drawn from existing clinical systems, it has many of the problems described above. In collaboration with the MIT researchers, we have begun a process of cleaning up the data and mapping the variable names and codes to LOINC codes. Our first step, which we describe here, was to map all of the laboratory test observations to LOINC codes. We were able to map 87% of the unique laboratory tests that cover 94% of the total number of laboratory tests results. Of the 13% of tests that we could not map, nearly 60% were due to test names whose real meaning could not be discerned and 29% represented tests that were not yet included in the LOINC table. These results suggest that LOINC codes cover most of laboratory tests used in critical care. We have delivered this work to the MIMIC-II researchers, who have included it in their standard MIMIC-II database release so that researchers who use this database in the future will not have to do this work. PMID:22561944

  19. 42 CFR 493.1445 - Standard; Laboratory director responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Standard; Laboratory director responsibilities. 493... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1445 Standard; Laboratory...

  20. 42 CFR 493.1407 - Standard; Laboratory director responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Standard; Laboratory director responsibilities. 493... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity Testing § 493.1407 Standard; Laboratory...

  1. 42 CFR 493.1445 - Standard; Laboratory director responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false Standard; Laboratory director responsibilities. 493... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1445 Standard; Laboratory...

  2. 42 CFR 493.1405 - Standard; Laboratory director qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false Standard; Laboratory director qualifications. 493... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity Testing § 493.1405 Standard; Laboratory...

  3. 42 CFR 493.1445 - Standard; Laboratory director responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 5 2014-10-01 2014-10-01 false Standard; Laboratory director responsibilities. 493... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1445 Standard; Laboratory...

  4. 42 CFR 493.1407 - Standard; Laboratory director responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 5 2014-10-01 2014-10-01 false Standard; Laboratory director responsibilities. 493... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity Testing § 493.1407 Standard; Laboratory...

  5. 42 CFR 493.1407 - Standard; Laboratory director responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false Standard; Laboratory director responsibilities. 493... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity Testing § 493.1407 Standard; Laboratory...

  6. Argonne's Laboratory Computing Resource Center : 2005 annual report.

    SciTech Connect

    Bair, R. B.; Coghlan, S. C; Kaushik, D. K.; Riley, K. R.; Valdes, J. V.; Pieper, G. P.

    2007-06-30

    Argonne National Laboratory founded the Laboratory Computing Resource Center in the spring of 2002 to help meet pressing program needs for computational modeling, simulation, and analysis. The guiding mission is to provide critical computing resources that accelerate the development of high-performance computing expertise, applications, and computations to meet the Laboratory's challenging science and engineering missions. The first goal of the LCRC was to deploy a mid-range supercomputing facility to support the unmet computational needs of the Laboratory. To this end, in September 2002, the Laboratory purchased a 350-node computing cluster from Linux NetworX. This cluster, named 'Jazz', achieved over a teraflop of computing power (10{sup 12} floating-point calculations per second) on standard tests, making it the Laboratory's first terascale computing system and one of the fifty fastest computers in the world at the time. Jazz was made available to early users in November 2002 while the system was undergoing development and configuration. In April 2003, Jazz was officially made available for production operation. Since then, the Jazz user community has grown steadily. By the end of fiscal year 2005, there were 62 active projects on Jazz involving over 320 scientists and engineers. These projects represent a wide cross-section of Laboratory expertise, including work in biosciences, chemistry, climate, computer science, engineering applications, environmental science, geoscience, information science, materials science, mathematics, nanoscience, nuclear engineering, and physics. Most important, many projects have achieved results that would have been unobtainable without such a computing resource. The LCRC continues to improve the computational science and engineering capability and quality at the Laboratory. Specific goals include expansion of the use of Jazz to new disciplines and Laboratory initiatives, teaming with Laboratory infrastructure providers to develop

  7. Putting the Laboratory at the Center of Teaching Chemistry

    ERIC Educational Resources Information Center

    Bopegedera, A. M. R. P.

    2011-01-01

    This article describes an effective approach to teaching chemistry by bringing the laboratory to the center of teaching, to bring the excitement of discovery to the learning process. The lectures and laboratories are closely integrated to provide a holistic learning experience. The laboratories progress from verification to open-inquiry and…

  8. The OSHA hazardous chemical occupational exposure standard for laboratories.

    PubMed

    Armbruster, D A

    1991-01-01

    OSHA's chemical occupational exposure standard for laboratories is an outgrowth of the previously issued Hazard Communication Standard. The standard relieves laboratories from complying with general industry standards but does require compliance with specific laboratory guidelines. The heart of the standard is the creation of a Chemical Hygiene Plan (CHP). The CHP addresses major issues such as safety equipment and procedures, work practices, training, the designation of a chemical hygiene officer, and the provision of medical consultation and examination for affected employees. This new standard, in full effect as of January 31, 1991, presents yet another regulatory challenge to laboratory managers but also ensures a safer environment for laboratory workers.

  9. The Hydrogen Technology Center at Wyle Laboratories

    NASA Astrophysics Data System (ADS)

    Wheelock, H.; Smith, D.; Frazier, J.

    1990-10-01

    A deactivated storable propellant test area with numerous test cells, large open concrete pads of up to 65-ft length, and two enclosed metal storage buildings, has been converted into a Hydrogen Technology Center. The conversion strategy involved extensive use of modified surplus equipment, well established testing technologies, and innovative engineering to obviate long-delivery time items. Simple, high heat flux water-to-cryogen heat exchangers are used to generate ambient temperature H2 and N gas. Hydrogen-fueled combustors were designed and fabricated to power the specialized heat exchangers required to support high-temperature hydrogen experiments. The facility has operated productively and safely since October, 1988.

  10. HEW to Set Laboratory Safety Standards.

    ERIC Educational Resources Information Center

    Chemical and Engineering News, 1978

    1978-01-01

    Describes Department of Health, Education and Welfare (HEW) proposed guidelines for laboratories using chemical carcinogens. The guidelines are designed to provide protection for laboratory workers and their environment from exposure to all types of carcinogenic agents. (GA)

  11. Assessment of Tutoring Laboratories in a Learning Assistance Center

    ERIC Educational Resources Information Center

    Fullmer, Patricia

    2012-01-01

    The Learning Resource Center at Lincoln University, Pennsylvania, provides tutoring laboratories that are required for developmental reading, writing, and math courses. This article reviews the processes used to plan and determine the effectiveness of the tutoring laboratories, including logic models, student learning outcomes, and the results of…

  12. VIEW TO EAST OF CRYSTALLIZATION LABORATORY (CENTER LEFT FOREGROUND), PAINT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW TO EAST OF CRYSTALLIZATION LABORATORY (CENTER LEFT FOREGROUND), PAINT APPLICATION BUILDING (CENTER BACKGROUND), AND c1944-1950 c1944-1950 POST-U.S. RADIUM ADDITION ADDITIONS TO EACH BUILDING (RIGHT FOREGROUND AND BACKGROUND) - United States Radium Corporation, 422-432 Alden Street, Orange, Essex County, NJ

  13. 42 CFR 493.1359 - Standard; PPM laboratory director responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Standard; PPM laboratory director responsibilities... AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Provider-Performed Microscopy (ppm) Procedures § 493.1359...

  14. 42 CFR 493.1359 - Standard; PPM laboratory director responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false Standard; PPM laboratory director responsibilities... AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Provider-Performed Microscopy (ppm) Procedures § 493.1359...

  15. 42 CFR 493.1359 - Standard; PPM laboratory director responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Standard; PPM laboratory director responsibilities... AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Provider-Performed Microscopy (ppm) Procedures § 493.1359...

  16. 42 CFR 493.1357 - Standard; laboratory director qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Standard; laboratory director qualifications. 493... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Provider-Performed Microscopy (ppm) Procedures § 493.1357...

  17. 42 CFR 493.1359 - Standard; PPM laboratory director responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Standard; PPM laboratory director responsibilities... AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Provider-Performed Microscopy (ppm) Procedures § 493.1359...

  18. 42 CFR 493.1357 - Standard; laboratory director qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false Standard; laboratory director qualifications. 493... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Provider-Performed Microscopy (ppm) Procedures § 493.1357...

  19. 42 CFR 493.1357 - Standard; laboratory director qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 5 2014-10-01 2014-10-01 false Standard; laboratory director qualifications. 493... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Provider-Performed Microscopy (ppm) Procedures § 493.1357...

  20. 42 CFR 493.1357 - Standard; laboratory director qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Standard; laboratory director qualifications. 493... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Provider-Performed Microscopy (ppm) Procedures § 493.1357...

  1. 42 CFR 493.1357 - Standard; laboratory director qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Standard; laboratory director qualifications. 493... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Provider-Performed Microscopy (ppm) Procedures § 493.1357...

  2. 42 CFR 493.1777 - Standard: Inspection of laboratories that have requested or have been issued a certificate of...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Standard: Inspection of laboratories that have requested or have been issued a certificate of compliance. 493.1777 Section 493.1777 Public Health CENTERS... CERTIFICATION LABORATORY REQUIREMENTS Inspection § 493.1777 Standard: Inspection of laboratories that...

  3. 42 CFR 493.1777 - Standard: Inspection of laboratories that have requested or have been issued a certificate of...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Standard: Inspection of laboratories that have requested or have been issued a certificate of compliance. 493.1777 Section 493.1777 Public Health CENTERS... CERTIFICATION LABORATORY REQUIREMENTS Inspection § 493.1777 Standard: Inspection of laboratories that...

  4. 42 CFR 493.1777 - Standard: Inspection of laboratories that have requested or have been issued a certificate of...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 5 2014-10-01 2014-10-01 false Standard: Inspection of laboratories that have requested or have been issued a certificate of compliance. 493.1777 Section 493.1777 Public Health CENTERS... CERTIFICATION LABORATORY REQUIREMENTS Inspection § 493.1777 Standard: Inspection of laboratories that...

  5. 42 CFR 493.1777 - Standard: Inspection of laboratories that have requested or have been issued a certificate of...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false Standard: Inspection of laboratories that have requested or have been issued a certificate of compliance. 493.1777 Section 493.1777 Public Health CENTERS... CERTIFICATION LABORATORY REQUIREMENTS Inspection § 493.1777 Standard: Inspection of laboratories that...

  6. 42 CFR 493.1777 - Standard: Inspection of laboratories that have requested or have been issued a certificate of...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Standard: Inspection of laboratories that have requested or have been issued a certificate of compliance. 493.1777 Section 493.1777 Public Health CENTERS... CERTIFICATION LABORATORY REQUIREMENTS Inspection § 493.1777 Standard: Inspection of laboratories that...

  7. VIEW OF THE INTERIOR OF BUILDING 125, THE STANDARDS LABORATORY. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF THE INTERIOR OF BUILDING 125, THE STANDARDS LABORATORY. THE PRIMARY FUNCTION OF THE STANDARDS LABORATORY WAS TO ENSURE AND IMPLEMENT A SYSTEM OF QUALITY CONTROL FOR INCOMING MATERIALS USED IN MANUFACTURING PROCESSES. SEVERAL ENGINEERING CONTROLS WERE USED TO ASSURE ACCURACY OF THE CALIBRATION PROCESSES INCLUDING: FLEX-FREE GRANITE TABLES, AIR LOCKED DOORS, TEMPERATURE CONTROLS, AND A SUPER-CLEAN ENVIRONMENT - Rocky Flats Plant, Standards Laboratory, Immediately north of 215A water tower & adjacent to Third Street, Golden, Jefferson County, CO

  8. Space and Missile Systems Center Standard: Software Development

    DTIC Science & Technology

    2015-01-16

    SPACE AND MISSILE SYSTEMS CENTER STANDARD SOFTWARE DEVELOPMENT APPROVED FOR PUBLIC RELEASE; DISTRIBUTION IS UNLIMITED Report...REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE Space and Missile Systems Center Standard: Software Development 5a. CONTRACT...technology developments . 2. This revised SMC standard comprises the text of The Aerospace Corporation report number TR-RS-2015-00012, entitled

  9. Internship at NASA Kennedy Space Center's Cryogenic Test laboratory

    NASA Technical Reports Server (NTRS)

    Holland, Katherine

    2013-01-01

    NASA's Kennedy Space Center (KSC) is known for hosting all of the United States manned rocket launches as well as many unmanned launches at low inclinations. Even though the Space Shuttle recently retired, they are continuing to support unmanned launches and modifying manned launch facilities. Before a rocket can be launched, it has to go through months of preparation, called processing. Pieces of a rocket and its payload may come in from anywhere in the nation or even the world. The facilities all around the center help integrate the rocket and prepare it for launch. As NASA prepares for the Space Launch System, a rocket designed to take astronauts beyond Low Earth Orbit throughout the solar system, technology development is crucial for enhancing launch capabilities at the KSC. The Cryogenics Test Laboratory at Kennedy Space Center greatly contributes to cryogenic research and technology development. The engineers and technicians that work there come up with new ways to efficiently store and transfer liquid cryogens. NASA has a great need for this research and technology development as it deals with cryogenic liquid hydrogen and liquid oxygen for rocket fuel, as well as long term space flight applications. Additionally, in this new era of space exploration, the Cryogenics Test Laboratory works with the commercial sector. One technology development project is the Liquid Hydrogen (LH2) Ground Operations Demonstration Unit (GODU). LH2 GODU intends to demonstrate increased efficiency in storing and transferring liquid hydrogen during processing, loading, launch and spaceflight of a spacecraft. During the Shuttle Program, only 55% of hydrogen purchased was used by the Space Shuttle Main Engines. GODU's goal is to demonstrate that this percentage can be increased to 75%. Figure 2 shows the GODU layout when I concluded my internship. The site will include a 33,000 gallon hydrogen tank (shown in cyan) with a heat exchanger inside the hydrogen tank attached to a

  10. Clinical Laboratories – Production Factories or Specialized Diagnostic Centers

    PubMed Central

    Tóth, Judit

    2016-01-01

    Since a large proportion of medical decisions are based on laboratory results, clinical laboratories should meet the increasing demand of clinicians and their patients. Huge central laboratories may process over 10 million tests annually; they act as production factories, measuring emergency and routine tests with sufficient speed and accuracy. At the same time, they also serve as specialized diagnostic centers where well-trained experts analyze and interpret special test results. It is essential to improve and constantly monitor this complex laboratory service, by several methods. Sample transport by pneumatic tube system, use of an advanced laboratory information system and point-of-care testing may result in decreased total turnaround time. The optimization of test ordering may result in a faster and more cost-effective laboratory service. Autovalidation can save time for laboratory specialists, when the analysis of more complex results requires their attention. Small teams of experts responsible for special diagnostic work, and their interpretative reporting according to predetermined principles, may help to minimize subjectivity of these special reports. Although laboratory investigations have become so diversely developed in the past decades, it is essential that the laboratory can provide accurate results relatively quickly, and that laboratory specialists can support the diagnosis and monitoring of patients by adequate interpretation of esoteric laboratory methods. PMID:27683528

  11. Precision Laboratory Standards of Mass and Laboratory Weights

    DTIC Science & Technology

    1954-08-20

    Preferred denominations for laboratory weights Classes P. Q, and T Classes 11 and Q Class 1P Metric Avoirdupois Apothecary Troy Grain Carat kg l. 0Z 0...I g., or 500 ing 10 IngAvorduoi.--------------------------------------8, 4, 2, or 1 11), or S oz I j; oz5 Apothecary ...jeceiiUte Assay toni (29.1667 g) ----- ----- T’ Carat (200 nig) - - - - - - - - - - D~rain, apothecaries ’- -(-- ---- - Ir ap G rain

  12. Highlighting High Performance Buildings: National Renewable Energy Laboratory's Visitors Center

    SciTech Connect

    2001-06-01

    The National Renewable Energy Laboratory Visitors Center, also known as the Dan Schaefer Federal Building, is a high-performance building located in Golden, Colorado. The 6,400-square-foot building incorporates passive solar heating, energy-efficient lighting, an evaporative cooling system, and other technologies to minimize energy costs and environmental impact. The Visitors Center displays a variety of interactive exhibits on energy efficiency and renewable energy, and the building includes an auditorium, a public reading room, and office space.

  13. Primary standards laboratory report, 1st half 1994

    SciTech Connect

    Not Available

    1994-11-01

    Sandia National Laboratories operates the Primary Standards Laboratory for the Department of Energy, Albuquerque Operations Office (DOE/AL). This report summarizes metrology activities that received emphasis in the first half of 1994 and provides information pertinent to the operation of the DOE/AL system-wide Standards and Calibration Program.

  14. Radioxenon standards used in laboratory inter-comparisons.

    PubMed

    Gohla, H; Auer, M; Cassette, Ph; Hague, R K; Lechermann, M; Nadalut, B

    2016-03-01

    Preparation methods for (133)Xe standards of activity concentration and the results of the 2014 (133)Xe laboratory inter-comparison exercise are described. One element of the quality assurance/quality control (QA/QC) program for laboratories of the International Monitoring System (IMS) will be regular inter-comparison exercises. However, until recently, no activity concentration standards for benchmarking were available. Therefore, two (133)Xe activity concentration reference standards were produced independently by Idaho National Laboratory and Seibersdorf Laboratories and used for the 2014 laboratory inter-comparison exercise. The preparation of a complementary (127)Xe activity concentration standard as well as a (127)Xe laboratory inter-comparison exercise suggests (127)Xe as a suitable isotope for QA/QC of remote IMS noble gas stations.

  15. Standard terminology in the laboratory and classroom

    NASA Technical Reports Server (NTRS)

    Strehlow, Richard A.

    1992-01-01

    Each of the materials produced by modern technologists is associated with a family of immaterials--all the concepts of substance, process, and purpose. It is concepts that are essential to transfer knowledge. It is concepts that are the stuff of terminology. Terminology is standardized today by companies, standards organizations, governments, and other groups. Simply described, it is the pre-negotiation of the meanings of terms. Terminology has become a key issue in businesses, and terminology knowledge is essential in understanding the modern world. The following is a introductory workshop discussing the concepts of terminology and methods of its standardization.

  16. Leading Antibacterial Laboratory Research by Integrating Conventional and Innovative Approaches: The Laboratory Center of the Antibacterial Resistance Leadership Group.

    PubMed

    Manca, Claudia; Hill, Carol; Hujer, Andrea M; Patel, Robin; Evans, Scott R; Bonomo, Robert A; Kreiswirth, Barry N

    2017-03-15

    The Antibacterial Resistance Leadership Group (ARLG) Laboratory Center (LC) leads the evaluation, development, and implementation of laboratory-based research by providing scientific leadership and supporting standard/specialized laboratory services. The LC has developed a physical biorepository and a virtual biorepository. The physical biorepository contains bacterial isolates from ARLG-funded studies located in a centralized laboratory and they are available to ARLG investigators. The Web-based virtual biorepository strain catalogue includes well-characterized gram-positive and gram-negative bacterial strains published by ARLG investigators. The LC, in collaboration with the ARLG Leadership and Operations Center, developed procedures for review and approval of strain requests, guidance during the selection process, and for shipping strains from the distributing laboratories to the requesting investigators. ARLG strains and scientific and/or technical guidance have been provided to basic research laboratories and diagnostic companies for research and development, facilitating collaboration between diagnostic companies and the ARLG Master Protocol for Evaluating Multiple Infection Diagnostics (MASTERMIND) initiative for evaluation of multiple diagnostic devices from a single patient sampling event. In addition, the LC has completed several laboratory-based studies designed to help evaluate new rapid molecular diagnostics by developing, testing, and applying a MASTERMIND approach using purified bacterial strains. In collaboration with the ARLG's Statistical and Data Management Center (SDMC), the LC has developed novel analytical strategies that integrate microbiologic and genetic data for improved and accurate identification of antimicrobial resistance. These novel approaches will aid in the design of future ARLG studies and help correlate pathogenic markers with clinical outcomes. The LC's accomplishments are the result of a successful collaboration with the ARLG

  17. National Center for Standards and Certification Information: Service and programs

    NASA Technical Reports Server (NTRS)

    Overman, Joanne

    1994-01-01

    The National Center for Standards and Certification Information (NCSCI) provides information on U.S., foreign and international voluntary standards, government regulations, and conformity assessment procedures for non-agricultural products. The Center serves as a referral service and focal point in the United States for information on standards and standards-related information. NCSCI staff respond to inquiries, maintain a reference collection of standards and standards-related documents, and serve as the U.S. inquiry point for information to and from foreign countries.

  18. Minimum Standards for Licensed Day Care Centers and Night-Time Centers. Revised Edition.

    ERIC Educational Resources Information Center

    Illinois State Dept. of Children and Family Services, Springfield.

    This document gives the minimum standards required for licensing day care centers and nighttime centers in the State of Illinois. The standards were established by the Department of Children and Family Services under the Child Care Act of 1969. Included in the publication are: (1) an explanation of the legal basis and application of standards; (2)…

  19. [Accreditation of clinical laboratories based on ISO standards].

    PubMed

    Kawai, Tadashi

    2004-11-01

    International Organization for Standardization (ISO) have published two international standards (IS) to be used for accreditation of clinical laboratories; ISO/IEC 17025:1999 and ISO 15189:2003. Any laboratory accreditation body must satisfy the requirements stated in ISO/IEC Guide 58. In order to maintain the quality of the laboratory accreditation bodies worldwide, the International Laboratory Accreditation Cooperation (ILAC) has established the mutual recognition arrangement (MRA). In Japan, the International Accreditation Japan (IAJapan) and the Japan Accreditation Board for Conformity Assessment (JAB) are the members of the ILAC/MRA group. In 2003, the Japanese Committee for Clinical Laboratory Standards (JCCLS) and the JAB have established the Development Committee of Clinical Laboratory Accreditation Program (CLAP), in order to establish the CLAP, probably starting in 2005.

  20. Transfer Standard Uncertainty Can Cause Inconclusive Inter-Laboratory Comparisons.

    PubMed

    Wright, John; Toman, Blaza; Mickan, Bodo; Wübbeler, Gerd; Bodnar, Olha; Elster, Clemens

    2016-12-01

    Inter-laboratory comparisons use the best available transfer standards to check the participants' uncertainty analyses, identify underestimated uncertainty claims or unknown measurement biases, and improve the global measurement system. For some measurands, instability of the transfer standard can lead to an inconclusive comparison result. If the transfer standard uncertainty is large relative to a participating laboratory's uncertainty, the commonly used standardized degree of equivalence ≤ 1 criterion does not always correctly assess whether a participant is working within their uncertainty claims. We show comparison results that demonstrate this issue and propose several criteria for assessing a comparison result as passing, failing, or inconclusive. We investigate the behavior of the standardized degree of equivalence and alternative comparison measures for a range of values of the transfer standard uncertainty relative to the individual laboratory uncertainty values. The proposed alternative criteria successfully discerned between passing, failing, and inconclusive comparison results for the cases we examined.

  1. NATIONAL ENVIRONMENTAL LABORATORY ACCREDITATION CONFERENCE (NELAC): CONSTITUTION, BYLAWS, AND STANDARDS

    EPA Science Inventory

    The principles and operating procedures for the National Environmental Laboratory Accreditation Conference (NELAC) are contained in the NELAC Constitution and Bylaws. The major portion of this document (standards) contains detailed requirements for accrediting environmental labo...

  2. Argonne Laboratory Computing Resource Center - FY2004 Report.

    SciTech Connect

    Bair, R.

    2005-04-14

    In the spring of 2002, Argonne National Laboratory founded the Laboratory Computing Resource Center, and in April 2003 LCRC began full operations with Argonne's first teraflops computing cluster. The LCRC's driving mission is to enable and promote computational science and engineering across the Laboratory, primarily by operating computing facilities and supporting application use and development. This report describes the scientific activities, computing facilities, and usage in the first eighteen months of LCRC operation. In this short time LCRC has had broad impact on programs across the Laboratory. The LCRC computing facility, Jazz, is available to the entire Laboratory community. In addition, the LCRC staff provides training in high-performance computing and guidance on application usage, code porting, and algorithm development. All Argonne personnel and collaborators are encouraged to take advantage of this computing resource and to provide input into the vision and plans for computing and computational analysis at Argonne. Steering for LCRC comes from the Computational Science Advisory Committee, composed of computing experts from many Laboratory divisions. The CSAC Allocations Committee makes decisions on individual project allocations for Jazz.

  3. Primary Standards Laboratory report, 2nd half 1993

    SciTech Connect

    Not Available

    1994-05-01

    The Primary Standards Laboratory (PSL) operates a system-wide primary standards and calibration program for the US Department of Energy, Albuquerque Field Office (DOE/AL). The PSL mission is as follows: to develop and maintain primary standards; to calibrate electrical, physical, and radiation reference standards for customer laboratories (DOE/AL nuclear weapon contractors); to conduct the technical surveys and measurement audits of these laboratories; and to recommend and implement system-wide improvements. This report summarizes activities of the PSL for the second half of 1993 and provides information pertinent to the operation of the DOE/AL Standards and Calibration Program. Specific areas covered include development projects, improvement projects, calibration and special measurements, surveys and audits, customer service, and significant events. Appendixes include certifications and reports;; a discussion about commercial calibration laboratories; PSL memoranda (PSLM); test numbers from the National Institute of Standards and Technology (NIST), formerly the National Bureau of Standards (NBS); and DOE/PSL memoranda on the Standards and Calibration Program with emphasis on traceability of PSL calibrations.

  4. Illinois Occupational Skill Standards: Clinical Laboratory Science/Biotechnology Cluster.

    ERIC Educational Resources Information Center

    Illinois Occupational Skill Standards and Credentialing Council, Carbondale.

    This document, which is intended to serve as a guide for workforce preparation program providers, details the Illinois Occupational Skill Standards for clinical laboratory occupations programs. The document begins with a brief overview of the Illinois perspective on occupational skill standards and credentialing, the process used to develop the…

  5. Illinois Occupational Skill Standards: Agricultural Laboratory and Field Technician Cluster.

    ERIC Educational Resources Information Center

    Illinois Occupational Skill Standards and Credentialing Council, Carbondale.

    These Illinois skill standards for the agricultural laboratory and field technician cluster are intended to serve as a guide to workforce preparation program providers as they define content for their programs and to employers as they establish the skills and standards necessary for job acquisition. They could also serve as a mechanism for…

  6. Transfer standard uncertainty can cause inconclusive inter-laboratory comparisons

    NASA Astrophysics Data System (ADS)

    Wright, John; Toman, Blaza; Mickan, Bodo; Wübbeler, Gerd; Bodnar, Olha; Elster, Clemens

    2016-12-01

    Inter-laboratory comparisons use the best available transfer standards to check the participants’ uncertainty analyses, identify underestimated uncertainty claims or unknown measurement biases, and improve the global measurement system. For some measurands, instability of the transfer standard can lead to an inconclusive comparison result. If the transfer standard uncertainty is large relative to a participating laboratory’s uncertainty, the commonly used standardized degree of equivalence  ⩽1 criterion does not always correctly assess whether a participant is working within their uncertainty claims. We show comparison results that demonstrate this issue and propose several criteria for assessing a comparison result as passing, failing, or inconclusive. We investigate the behavior of the standardized degree of equivalence and alternative comparison measures for a range of values of the transfer standard uncertainty relative to the individual laboratory uncertainty values. The proposed alternative criteria successfully discerned between passing, failing, and inconclusive comparison results for the cases we examined.

  7. Serological Diagnosis of Paracoccidioidomycosis: High Rate of Inter-laboratorial Variability among Medical Mycology Reference Centers

    PubMed Central

    Vidal, Monica Scarpelli Martinelli; Del Negro, Gilda Maria Barbaro; Vicentini, Adriana Pardini; Svidzinski, Teresinha Inez Estivalet; Mendes-Giannini, Maria Jose; Almeida, Ana Marisa Fusco; Martinez, Roberto; de Camargo, Zoilo Pires; Taborda, Carlos Pelleschi; Benard, Gil

    2014-01-01

    Background Serological tests have long been established as rapid, simple and inexpensive tools for the diagnosis and follow-up of PCM. However, different protocols and antigen preparations are used and the few attempts to standardize the routine serological methods have not succeeded. Methodology/Principal findings We compared the performance of six Brazilian reference centers for serological diagnosis of PCM. Each center provided 30 sera of PCM patients, with positive high, intermediate and low titers, which were defined as the “reference” titers. Each center then applied its own antigen preparation and serological routine test, either semiquantitative double immunodifusion or counterimmmunoelectrophoresis, in the 150 sera from the other five centers blindly as regard to the “reference” titers. Titers were transformed into scores: 0 (negative), 1 (healing titers), 2 (active disease, low titers) and 3 (active disease, high titers) according to each center's criteria. Major discordances were considered between scores indicating active disease and scores indicating negative or healing titers; such discordance when associated with proper clinical and other laboratorial data, may correspond to different approaches to the patient's treatment. Surprisingly, all centers exhibited a high rate of “major” discordances with a mean of 31 (20%) discordant scores. Alternatively, when the scores given by one center to their own sera were compared with the scores given to their sera by the remaining five other centers, a high rate of major discordances was also found, with a mean number of 14.8 sera in 30 presenting a discordance with at least one other center. The data also suggest that centers that used CIE and pool of isolates for antigen preparation performed better. Conclusion There are inconsistencies among the laboratories that are strong enough to result in conflicting information regarding the patients' treatment. Renewed efforts should be promoted to improve

  8. Clinical trials of boron neutron capture therapy [in humans] [at Beth Israel Deaconess Medical Center][at Brookhaven National Laboratory

    SciTech Connect

    Wallace, Christine

    2001-05-29

    Assessment of research records of Boron Neutron Capture Therapy was conducted at Brookhaven National Laboratory and Beth Israel Deaconess Medical Center using the Code of Federal Regulations, FDA Regulations and Good Clinical Practice Guidelines. Clinical data were collected from subjects' research charts, and differences in conduct of studies at both centers were examined. Records maintained at Brookhaven National Laboratory were not in compliance with regulatory standards. Beth Israel's records followed federal regulations. Deficiencies discovered at both sites are discussed in the reports.

  9. MANUAL OF STANDARDS FOR REHABILITATION CENTERS AND FACILITIES.

    ERIC Educational Resources Information Center

    CANIFF, CHARLES E.; AND OTHERS

    A 5-YEAR PROJECT TO SPECIFY STANDARDS OF REHABILITATION CENTERS AND FACILITIES RESULTED IN THREE PUBLICATIONS. THIS MANUAL INCLUDES THE CHARACTERISTICS AND GOALS OF REHABILITATION FACILITIES. THE STANDARDS FOR ORGANIZATION, SERVICES THAT SHOULD BE PROVIDED, PERSONNEL INCLUDED, RECORDS AND REPORTS, FISCAL MANAGEMENT, AND THE PHYSICAL PLANT ARE…

  10. Argonne's Laboratory Computing Resource Center 2009 annual report.

    SciTech Connect

    Bair, R. B.

    2011-05-13

    Now in its seventh year of operation, the Laboratory Computing Resource Center (LCRC) continues to be an integral component of science and engineering research at Argonne, supporting a diverse portfolio of projects for the U.S. Department of Energy and other sponsors. The LCRC's ongoing mission is to enable and promote computational science and engineering across the Laboratory, primarily by operating computing facilities and supporting high-performance computing application use and development. This report describes scientific activities carried out with LCRC resources in 2009 and the broad impact on programs across the Laboratory. The LCRC computing facility, Jazz, is available to the entire Laboratory community. In addition, the LCRC staff provides training in high-performance computing and guidance on application usage, code porting, and algorithm development. All Argonne personnel and collaborators are encouraged to take advantage of this computing resource and to provide input into the vision and plans for computing and computational analysis at Argonne. The LCRC Allocations Committee makes decisions on individual project allocations for Jazz. Committee members are appointed by the Associate Laboratory Directors and span a range of computational disciplines. The 350-node LCRC cluster, Jazz, began production service in April 2003 and has been a research work horse ever since. Hosting a wealth of software tools and applications and achieving high availability year after year, researchers can count on Jazz to achieve project milestones and enable breakthroughs. Over the years, many projects have achieved results that would have been unobtainable without such a computing resource. In fiscal year 2009, there were 49 active projects representing a wide cross-section of Laboratory research and almost all research divisions.

  11. The program of the ALARA Center at Brookhaven National Laboratory

    SciTech Connect

    Khan, T.A.; Baum, J.W.

    1993-01-01

    In 1984 the Brookhaven National Laboratory was asked by the Nuclear Regulatory Commission to set up a Center to monitor dose-reduction efforts in the US and abroad and to focus the industry's attention on ALARA. The paper summarizes the main work of the ALARA Center between 1984 and 1992. The Center maintains nine data bases for the NRC and the Nuclear Power Industry. These databases are constantly updated and access to them is provided through a personal computer and a modem and by periodic publications in the form of a newsletter and NUREG reports. Also described briefly are eight other projects related to dose-reduction at nuclear power plants that the Center has carried out for the NRC. Among these are projects that analyze the cost-effectiveness of engineering modifications, look at worldwide activities at dose reduction and compare US and foreign dose experience, examine high-dose worker groups and high-dose jobs, develop optimum techniques to control contamination at nuclear plants, and look at the doses being received by men and women in all sectors of the nuclear industry.

  12. The program of the ALARA Center at Brookhaven National Laboratory

    SciTech Connect

    Khan, T.A.; Baum, J.W.

    1993-04-01

    In 1984 the Brookhaven National Laboratory was asked by the Nuclear Regulatory Commission to set up a Center to monitor dose-reduction efforts in the US and abroad and to focus the industry`s attention on ALARA. The paper summarizes the main work of the ALARA Center between 1984 and 1992. The Center maintains nine data bases for the NRC and the Nuclear Power Industry. These databases are constantly updated and access to them is provided through a personal computer and a modem and by periodic publications in the form of a newsletter and NUREG reports. Also described briefly are eight other projects related to dose-reduction at nuclear power plants that the Center has carried out for the NRC. Among these are projects that analyze the cost-effectiveness of engineering modifications, look at worldwide activities at dose reduction and compare US and foreign dose experience, examine high-dose worker groups and high-dose jobs, develop optimum techniques to control contamination at nuclear plants, and look at the doses being received by men and women in all sectors of the nuclear industry.

  13. Secondary calibration laboratory for ionizing radiation laboratory accreitation program National Institute of Standards and Technology National Voluntary Laboratory Accreditation Program

    SciTech Connect

    Martin, P.R.

    1993-12-31

    This paper presents an overview of the procedures and requirements for accreditation under the Secondary Calibration Laboratory for Ionizing Radiation Program (SCLIR LAP). The requirements for a quality system, proficiency testing and the onsite assessment are discussed. The purpose of the accreditation program is to establish a network of secondary calibration laboratories that can provide calibrations traceable to the primary national standards.

  14. DOE standard: The Department of Energy Laboratory Accreditation Program administration

    SciTech Connect

    1998-12-01

    This technical standard describes the US Department of Energy Laboratory Accreditation Program (DOELAP), organizational responsibilities, and the accreditation process. DOELAP evaluates and accredits personnel dosimetry and radiobioassay programs used for worker monitoring and protection at DOE and DOE contractor sites and facilities as required in Title 10, Code of Federal Regulations, Part 835, Occupational Radiation Protection. The purpose of this technical standard is to establish procedures for administering DOELAP and acquiring accreditation.

  15. Manned Space-laboratories Control Center (MSCC) operations concept

    NASA Technical Reports Server (NTRS)

    Kehr, Joachim

    1993-01-01

    The initiation of the (German-) nationally funded control center for manned spaceflight operations triggered by the invitation of President Reagan to ESA, Japan, and Canada in 1984 to join the International Space Station Freedom Program is recalled. The requirements for a Manned Space-Laboratories Control Center (MSCC) as defined at the beginning of the planning and construction process in 1987 and the resulting modifications during the various programmatic scenario changes on NASA and ESA side between 1987 and now are presented. The validity of the original requirements with respect to the current scenario, which asks for a logical evolution from the execution of the D-2 mission in January 1993 via the European Columbus Precursor flights (in particular the E-1 mission) towards Columbus Attached Laboratory (APM)-operations by the end of this century are discussed. The resulting tasks of the MSCC for the various missions, the current configuration, and the ensuing operations concept leading from a more centralized concept for D-2 towards a decentralized payload operations concept for the APM and the implications with respect to European and International interfaces are presented. The planned Columbus MSCC facility architecture and its expected modifications introduced by the ESA Ministerial Conference in Munich (Nov. 1991) and follow-on discussions are briefly addressed. The last chapter outlines the planned services to be provided by the MSCC to the decentralized User (experimenter) community. Issues like decentralized mission planning on executional level, command validation, data flow coordination, archiving services, and telescience capabilities are highlighted from a MSCC point of view.

  16. Standards, Regulation and Registration of Dental Laboratories. An Industry Update.

    PubMed

    Giovannone, Paul L

    2015-01-01

    State dental associations are showing increased interest in maintaining current standards and regulations affecting the dental laboratory industry as mandated by the Food and Drug Administration. The domestic dental laboratory industry is being significantly stressed by foreign competition, rapid technology development and unprecedented consolidation, which are changing the way that prosthetic devices and restorations are manufactured and delivered to dentists. Of paramount importance to the prescribing dentist is the accurate documentation of the source and materials being used in prostheses being delivered to patients.

  17. A report from the AVS Standards Committee - Comparison of ion gauge calibrations by several standards laboratories

    NASA Technical Reports Server (NTRS)

    Warshawsky, I.

    1982-01-01

    Calibrations by four U.S. laboratories of four hot-cathode ion gauges, in the range 0.07-13 mPa, showed systematic differences among laboratories that were much larger than the expected error of any one calibration. They also suggested that any of the four gauges tested, if properly packaged and shipped, was able to serve as a transfer standard with probable error of 2%. A second comparison was made of the calibrations by two U.S. laboratories of some other gauges that had also been calibrated by the National Physical Laboratory, England. Results did not permit conclusive determination of whether differences were due to the laboratories or to changes in the gauges.

  18. Space and Missile Systems Center Standard: Space Flight Pressurized Systems

    DTIC Science & Technology

    2015-02-28

    SPACE AND MISSILE SYSTEMS CENTER STANDARD SPACE FLIGHT PRESSURIZED SYSTEMS APPROVED FOR PUBLIC RELEASE...Space Flight Pressurized Systems 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER...Corporation report number TR-RS-2014-00005, entitled Design and Test Requirements for Space Flight Pressurized Systems. The major changes in this release are

  19. Marshall Space Flight Center Materials and Processes Laboratory

    NASA Technical Reports Server (NTRS)

    Tramel, Terri L.

    2012-01-01

    Marshall?s Materials and Processes Laboratory has been a core capability for NASA for over fifty years. MSFC has a proven heritage and recognized expertise in materials and manufacturing that are essential to enable and sustain space exploration. Marshall provides a "systems-wise" capability for applied research, flight hardware development, and sustaining engineering. Our history of leadership and achievements in materials, manufacturing, and flight experiments includes Apollo, Skylab, Mir, Spacelab, Shuttle (Space Shuttle Main Engine, External Tank, Reusable Solid Rocket Motor, and Solid Rocket Booster), Hubble, Chandra, and the International Space Station. MSFC?s National Center for Advanced Manufacturing, NCAM, facilitates major M&P advanced manufacturing partnership activities with academia, industry and other local, state and federal government agencies. The Materials and Processes Laborato ry has principal competencies in metals, composites, ceramics, additive manufacturing, materials and process modeling and simulation, space environmental effects, non-destructive evaluation, and fracture and failure analysis provide products ranging from materials research in space to fully integrated solutions for large complex systems challenges. Marshall?s materials research, development and manufacturing capabilities assure that NASA and National missions have access to cutting-edge, cost-effective engineering design and production options that are frugal in using design margins and are verified as safe and reliable. These are all critical factors in both future mission success and affordability.

  20. NASA Glenn Research Center Acoustical Testing Laboratory: Five year retrospective

    NASA Astrophysics Data System (ADS)

    Cooper, Beth A.; Akers, James C.; Passe, Paul J.

    2005-09-01

    In the five years since the NASA Glenn Research Center Acoustical Testing Laboratory (ATL) opened its doors in September, 2000, it has developed a comprehensive array of services and products that support hearing conservation goals within NASA and industry. The ATL provides acoustic emission testing and noise control engineering services for a variety of specialized customers, particularly developers of equipment and science experiments manifested for NASA's manned space missions. The ATL aggressively supports the vision of a low-noise on-orbit environment, which facilitates mission success as well as crew health, safety, and comfort. In concert with these goals, the ATL also produces and distributes free educational resources and low-noise advocacy tools for hearing conservation education and awareness. Among these are two compact discs of auditory demonstrations (of phenomena in acoustics, hearing conservation, and communication), and presentations, software packages, and other educational materials for use by engineers, audiologists, and other hearing conservation stakeholders. This presentation will highlight ATL's construction, history, technical capabilities, and current projects and will feature demonstrations of some of the unique educational resource materials that are distributed by the ATL.

  1. [Development of laboratory information system--quality standards].

    PubMed

    Srenger, Vesna; Stavljenić-Rukavina, Ana; Cvorisćec, Dubravka; Brkljacić, Vera; Rogić, Dunja; Juricić, Ljiljana

    2005-01-01

    The aim of the study was to determine structural modules of laboratory information system (LIS) for the application of new biomedical and information technologies by utilizing current organizational trends. The method used included definition of structural modules according to significant LIS properties, e.g., a large number of data, automation of analyses and rapid exchange of information, and according to the process of information establishment the collection, organization, selection, synthesis and distribution. Thus, outdated distributed software at the Clinical Institute of Laboratory Diagnosis has now been replaced by modular organization. Modules have been developed for the following: data input, online operation of laboratory instruments, preparation of results, compilation of medical documentation on quality assurance based on the application of quality standards, management of finances, and for point of care testing. The method of re-engineering as well as adherence to EN and ISO quality standards were utilized in planning the development of LIS based on the application of new information technologies and in shaping business processes. The application of re-engineering in LIS development results in quality improvement, reduces the cost and time necessary for performance of procedures, and improves relations in organizational structure.

  2. 46 CFR 159.010-3 - Independent laboratory: Standards for acceptance.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 6 2013-10-01 2013-10-01 false Independent laboratory: Standards for acceptance. 159... Laboratory: Acceptance, Recognition, and Termination § 159.010-3 Independent laboratory: Standards for acceptance. (a) To be accepted by the Coast Guard as an independent laboratory, a laboratory must— (1)...

  3. 46 CFR 159.010-3 - Independent laboratory: Standards for acceptance.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 6 2014-10-01 2014-10-01 false Independent laboratory: Standards for acceptance. 159... Laboratory: Acceptance, Recognition, and Termination § 159.010-3 Independent laboratory: Standards for acceptance. (a) To be accepted by the Coast Guard as an independent laboratory, a laboratory must— (1)...

  4. 46 CFR 159.010-3 - Independent laboratory: Standards for acceptance.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 6 2011-10-01 2011-10-01 false Independent laboratory: Standards for acceptance. 159... Laboratory: Acceptance, Recognition, and Termination § 159.010-3 Independent laboratory: Standards for acceptance. (a) To be accepted by the Coast Guard as an independent laboratory, a laboratory must— (1)...

  5. 46 CFR 159.010-3 - Independent laboratory: Standards for acceptance.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 6 2012-10-01 2012-10-01 false Independent laboratory: Standards for acceptance. 159... Laboratory: Acceptance, Recognition, and Termination § 159.010-3 Independent laboratory: Standards for acceptance. (a) To be accepted by the Coast Guard as an independent laboratory, a laboratory must— (1)...

  6. 40 CFR 262.103 - What is the scope of the laboratory environmental management standard?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 27 2012-07-01 2012-07-01 false What is the scope of the laboratory... University Laboratories XL Project-Laboratory Environmental Management Standard § 262.103 What is the scope of the laboratory environmental management standard? The Laboratory Environmental Management...

  7. Iodine Standard Materials: Preparation and Inter-Laboratory Comparisons

    SciTech Connect

    D D Jenson; M L Adamic; J E Olson; M G Watrous; C Vockenhuber

    2014-08-01

    The Idaho National Laboratory is preparing to enter the community of AMS practioners who analyze for 129Iodine. We expect to take delivery of a 0.5 MV compact accelerator mass spectrometry system, built by NEC, in the early summer of 2014. The primary mission for this instrument is iodine; it is designed to analyze iodine in the +3 charge state. As part of the acceptance testing for this instrument, both at NEC and on-site in our laboratory, some sort of standard or reference material is needed to verify performance. Appropriate standard materials are not readily available in the commercial marketplace. Small quantities can sometimes be acquired from other laboratories already engaged in iodine analyses. In the longer-term, meaningful quantities of standard materials are needed for routine use in analyses, and for quality control functions1. We have prepared some standard materials, starting with elemental Woodward iodine and NIST SRM 3231 [Iodine-129 Isotopic Standard (high level)] 10-6 solution. The goal was to make mixtures at the 5x10-10, 5x10-11, 5x10-12 ratio levels, along with some unmodified Woodward, in the chemical form of silver iodide. Approximately twenty grams of each of these mixtures were prepared. The elemental Woodward iodine was dissolved in chloroform, then reduced to iodide using sodium bisulfite in water. At this point the NIST spike material was added, in the form of sodium iodide. The mixed iodides were oxidized back to iodine in chloroform using hydrogen peroxide. This oxidation step was essential for isotopic equilibration of the 127 and 129 atoms. The iodine was reduced to iodide using sodium bisulfite as before. Excess sulfites and sulfates were precipitated with barium nitrate. After decanting, silver nitrate was used to precipitate the desired silver iodide. Once the silver iodide was produced, the material was kept in darkness as much as possible to minimize photo-oxidation. The various mixtures were synthesized independently of each

  8. Services of the CDRH X-ray calibration laboratory and their traceability to National Standards

    SciTech Connect

    Cerra, F.; Heaton, H.T.

    1993-12-31

    The X-ray Calibration Laboratory (XCL) of the Center for Devices and Radiological Health (CDRH) provides calibration services for the Food and Drug Administration (FDA). The instruments calibrated are used by FDA and contract state inspectors to verify compliance with federal x-ray performance standards and for national surveys of x-ray trends. In order to provide traceability of measurements, the CDRH XCL is accredited by the National Voluntary Laboratory Accreditation Program (NVLAP) for reference, diagnostic, and x-ray survey instrument calibrations. In addition to these accredited services, the CDRH XCL also calibrates non-invasive kVp meters in single- and three-phase x-ray beams, and thermoluminescent dosimeter (TLD) chips used to measure CT beam profiles. The poster illustrates these services and shows the traceability links back to the National Standards.

  9. Environmental Sciences Division Toxicology Laboratory standard operating procedures

    SciTech Connect

    Kszos, L.A.; Stewart, A.J.; Wicker, L.F.; Logsdon, G.M.

    1989-09-01

    This document was developed to provide the personnel working in the Environmental Sciences Division's Toxicology Laboratory with documented methods for conducting toxicity tests. The document consists of two parts. The first part includes the standard operating procedures (SOPs) that are used by the laboratory in conducting toxicity tests. The second part includes reference procedures from the US Environmental Protection Agency document entitled Short-Term Methods for Estimating the Chronic Toxicity of Effluents and Receiving Waters to Freshwater Organisms, upon which the Toxicology Laboratory's SOPs are based. Five of the SOPs include procedures for preparing Ceriodaphnia survival and reproduction test. These SOPs include procedures for preparing Ceriodaphnia food (SOP-3), maintaining Ceriodaphnia cultures (SOP-4), conducting the toxicity test (SOP-13), analyzing the test data (SOP-13), and conducting a Ceriodaphnia reference test (SOP-15). Five additional SOPs relate specifically to the fathead minnow (Pimephales promelas) larval survival and growth test: methods for preparing fathead minnow larvae food (SOP-5), maintaining fathead minnow cultures (SOP-6), conducting the toxicity test (SOP-9), analyzing the test data (SOP-12), and conducting a fathead minnow reference test (DOP-14). The six remaining SOPs describe methods that are used with either or both tests: preparation of control/dilution water (SOP-1), washing of glassware (SOP-2), collection and handling of samples (SOP-7), preparation of samples (SOP-8), performance of chemical analyses (SOP-11), and data logging and care of technical notebooks (SOP-16).

  10. A Discussion of the Draft Proposal for Data Exchange Standards for Clinical Laboratory Results

    PubMed Central

    McDonald, Clement; Wiederhold, Gio; Simborg, Donald W.; Hammond, Ed; Jelovsek, Fredrick R.; Schneider, Ken

    1984-01-01

    A task force of AAMSI is developing standards for data exchange between laboratory and clinical practice. An early draft standard is presented. We look for criticism and comments from commercial laboratories, hospitals, system developers and other interested parties.

  11. Inquiry-based laboratory investigations and student performance on standardized tests in biological science

    NASA Astrophysics Data System (ADS)

    Patke, Usha

    Achievement data from the 3rd International Mathematics and Sciences Study and Program for International Student Assessment in science have indicated that Black students from economically disadvantaged families underachieve at alarming rates in comparison to White and economically advantaged peer groups. The study site was a predominately Black, urban school district experiencing underachievement. The purpose of this correlational study was to examine the relationship between students' use of inquiry-based laboratory investigations and their performance on the Biology End of Course Test, as well as to examine the relationship while partialling out the effects of student gender. Constructivist theory formed the theoretical foundation of the study. Students' perceived levels of experience with inquiry-based laboratory investigations were measured using the Laboratory Program Variable Inventory (LPVI) survey. LPVI scores of 256 students were correlated with test scores and were examined by student gender. The Pearson correlation coefficient revealed a small direct correlation between students' experience in inquiry-based laboratory investigation classes and standardized test scores on the Biology EOCT. A partial correlational analysis indicated that the correlation remained after controlling for gender. This study may prompt a change from teacher-centered to student-centered pedagogy at the local site in order to increase academic achievement for all students. The results of this study may also influence administrators and policy makers to initiate local, state, or nationwide curricular development. A change in curriculum may promote social change as students become more competent, and more able, to succeed in life beyond secondary school.

  12. Standardization of pathology laboratories in Pakistan: problems and prospects.

    PubMed

    Ahmad, Manzoor; Khan, Farooq Ahmad; Ahmad, Sadia Atif

    2009-03-01

    A Total Quality Management System with an internationally recognized accreditation process is the only guarantee of a reliable pathology service. However in a developing country like Pakistan nearly 90% of labs are small and without adequate physical and man power infrastructures. A modified plan may have to be tailored for them. A two tier system has been formulated. Accreditation based on ISO 15189 is to be introduced on voluntary basis. The labs which do not qualify for international standardization would be brought into quality net through a registration process. All such labs will be initiated into a simplified quality management system. Participation in proficiency testing program will be mandatory. They will be provided education and training to become eligible for accreditation. It is hoped that this simplified system will provide an impetus for evolving a workable and comprehensive mechanism through which pathology laboratories in the country will be able to offer better and more reliable services.

  13. 77 FR 14805 - Clinical Laboratory Improvement Advisory Committee, Centers for Disease Control and Prevention...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-13

    ... HUMAN SERVICES Centers for Disease Control and Prevention Clinical Laboratory Improvement Advisory Committee, Centers for Disease Control and Prevention: Notice of Charter Renewal This gives notice under the... Improvement Advisory Committee, Centers for Disease Control and Prevention (CDC), Department of Health...

  14. Hydrogen Field Test Standard: Laboratory and Field Performance

    PubMed Central

    Pope, Jodie G.; Wright, John D.

    2015-01-01

    The National Institute of Standards and Technology (NIST) developed a prototype field test standard (FTS) that incorporates three test methods that could be used by state weights and measures inspectors to periodically verify the accuracy of retail hydrogen dispensers, much as gasoline dispensers are tested today. The three field test methods are: 1) gravimetric, 2) Pressure, Volume, Temperature (PVT), and 3) master meter. The FTS was tested in NIST's Transient Flow Facility with helium gas and in the field at a hydrogen dispenser location. All three methods agree within 0.57 % and 1.53 % for all test drafts of helium gas in the laboratory setting and of hydrogen gas in the field, respectively. The time required to perform six test drafts is similar for all three methods, ranging from 6 h for the gravimetric and master meter methods to 8 h for the PVT method. The laboratory tests show that 1) it is critical to wait for thermal equilibrium to achieve density measurements in the FTS that meet the desired uncertainty requirements for the PVT and master meter methods; in general, we found a wait time of 20 minutes introduces errors < 0.1 % and < 0.04 % in the PVT and master meter methods, respectively and 2) buoyancy corrections are important for the lowest uncertainty gravimetric measurements. The field tests show that sensor drift can become a largest component of uncertainty that is not present in the laboratory setting. The scale was calibrated after it was set up at the field location. Checks of the calibration throughout testing showed drift of 0.031 %. Calibration of the master meter and the pressure sensors prior to travel to the field location and upon return showed significant drifts in their calibrations; 0.14 % and up to 1.7 %, respectively. This highlights the need for better sensor selection and/or more robust sensor testing prior to putting into field service. All three test methods are capable of being successfully performed in the field and give

  15. Langley Research Center Standard for the Evaluation of Socket Welds

    NASA Technical Reports Server (NTRS)

    Berry, R. F., Jr.

    1985-01-01

    A specification utilized for the nondestructive evaluation of socket type pipe joints at Langley Research Center (LaRC) is discussed. The scope of hardware shall include, but is not limited to, all common pipe fittings: tees, elbows, couplings, caps, and so forth, socket type flanges, unions, and valves. In addition, the exterior weld of slip on flanges shall be inspected using this specification. At the discretion of the design engineer, standard practice engineer, Fracture Mechanics Engineering Section, Pressure Systems Committee, or other authority, four nondestructive evaluation techniques may be utilized exclusively, or in combination, to inspect socket type welds. These techniques are visual, radiographic, magnetic particle, and dye penetrant. Under special circumstances, other techniques (such as eddy current or ultrasonics) may be required and their application shall be guided by the appropriate sections of the American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel Code (B&PVC).

  16. Integrating standard operating procedures and industry notebook standards to evaluate students in laboratory courses.

    PubMed

    Wallert, Mark A; Provost, Joseph J

    2014-01-01

    To enhance the preparedness of graduates from the Biochemistry and Biotechnology (BCBT) Major at Minnesota State University Moorhead for employment in the bioscience industry we have developed a new Industry certificate program. The BCBT Industry Certificate was developed to address specific skill sets that local, regional, and national industry experts identified as lacking in new B.S. and B.A. biochemistry graduates. The industry certificate addresses concerns related to working in a regulated industry such as Good Laboratory Practices, Good Manufacturing Practices, and working in a Quality System. In this article we specifically describe how we developed a validation course that uses Standard Operating Procedures to describe grading policy and laboratory notebook requirements in an effort to better prepare students to transition into industry careers.

  17. Standards for thyroid laboratory testing, and cognitive functions after menopause

    PubMed Central

    Bejga, Przemysław; Witczak, Mariusz; Łyszcz, Robert; Makara-Studzinska, Marta

    2014-01-01

    Introduction The aim of the study is to analyze the relationship between normative and non-normative thyroid tests (TSH, TT4, TT3, FT3, FT4, anti-TPO, anti-Tg, AB-TSHR) and the level of cognitive functions in postmenopausal women. Material and methods The study group consisted of 383 women from south-eastern Poland, aged 50-65 years. The cognitive functions were evaluated using a diagnostic instrument – Central Nervous System – Vital Signs (CNS-VS). Blood was collected for determination of the following parameters: TSH, TT4, TT3, FT3, FT4, anti-TPO, anti-Tg, AB-TSHR. Results There were significant differences in NCI, executive functions, psychomotor speed, reaction time, complex attention and cognitive flexibility, depending on the normative and non-normative level of TSH. Women whose level of FT3 was at the lower limit of the normal range obtained poorer results in psychomotor speed, while subjects with levels of FT4 below the standard achieved significantly lower scores for this function. The relationship between NCI and cognitive functions, and the normative and non-normative anti-TPO results, showed significant differences in verbal memory, visual memory, processing speed and reaction time. The level of AB-TSHR reported as normal or above the norm significantly differentiated from the results of NCI, processing speed, executive functions, psychomotor speed, complex attention and cognitive flexibility. Conclusions Concentrations of laboratory parameters assessing the thyroid function located within the upper limits of the normal range showed a different relationship with the cognitive performance than concentrations located within the lower limits of the standard. PMID:26327860

  18. Workshop on laboratory protocol standards for the Molecular Methods Database.

    PubMed

    Klingström, Tomas; Soldatova, Larissa; Stevens, Robert; Roos, T Erik; Swertz, Morris A; Müller, Kristian M; Kalaš, Matúš; Lambrix, Patrick; Taussig, Michael J; Litton, Jan-Eric; Landegren, Ulf; Bongcam-Rudloff, Erik

    2013-01-25

    Management of data to produce scientific knowledge is a key challenge for biological research in the 21st century. Emerging high-throughput technologies allow life science researchers to produce big data at speeds and in amounts that were unthinkable just a few years ago. This places high demands on all aspects of the workflow: from data capture (including the experimental constraints of the experiment), analysis and preservation, to peer-reviewed publication of results. Failure to recognise the issues at each level can lead to serious conflicts and mistakes; research may then be compromised as a result of the publication of non-coherent protocols, or the misinterpretation of published data. In this report, we present the results from a workshop that was organised to create an ontological data-modelling framework for Laboratory Protocol Standards for the Molecular Methods Database (MolMeth). The workshop provided a set of short- and long-term goals for the MolMeth database, the most important being the decision to use the established EXACT description of biomedical ontologies as a starting point.

  19. Standardized Laboratory Feeding of Larval Aedes japonicus japonicus (Diptera: Culicidae).

    PubMed

    Bock, Friederike; Kuch, Ulrich; Pfenninger, Markus; Müller, Ruth

    2015-01-01

    The Asian bush mosquito (Aedes japonicus japonicus, Theobald 1901) is an invasive culicid species which originates in Asia but is nowadays present in northern America and Europe. It is a competent vector for several human disease pathogens. In addition to the public health threat, this invasive species may also be an ecological threat for native container-breeding mosquitoes which share a similar larval habitat. Therefore, it is of importance to gain knowledge on ecological and eco-toxicological features of the Asian bush mosquito. However, optimal laboratory feeding conditions have not yet been established. Standardized feeding methods will be needed in assessing the impact of insecticides or competitional strength of this species. To fill this gap, we performed experiments on food quality and quantity for Ae. j. japonicus larvae. We found out that the commercial fish food TetraMin (Tetra, Melle, Germany) in a dose of 10 mg per larva is the most suitable food tested. We also suggest a protocol with a feeding sequence of seven portions for all larval stages of this species.

  20. 42 CFR 493.1443 - Standard; Laboratory director qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... earned doctoral degree in a chemical, physical, biological, or clinical laboratory science from an... laboratory director under regulations at 42 CFR 493.1415, published March 14, 1990 at 55 FR 9538, on...

  1. 42 CFR 493.1443 - Standard; Laboratory director qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... earned doctoral degree in a chemical, physical, biological, or clinical laboratory science from an... laboratory director under regulations at 42 CFR 493.1415, published March 14, 1990 at 55 FR 9538, on...

  2. 42 CFR 493.1407 - Standard; Laboratory director responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... assessment programs are established and maintained to assure the quality of laboratory services provided and... developed and used for each of the tests performed in the laboratory provide quality laboratory services for... capability of providing the quality of results required for patient care; (ii) Verification procedures...

  3. About Region 3's Laboratory and Field Services at EPA's Environmental Science Center

    EPA Pesticide Factsheets

    Mission & contact information for EPA Region 3's Laboratory and Field Services located at EPA's Environmental Science Center: the Office of Analytical Services and Quality Assurance & Field Inspection Program

  4. Capability of the Gas Analysis and Testing Laboratory at the NASA Johnson Space Center

    NASA Technical Reports Server (NTRS)

    Broerman, Craig; Jimenez, Javier; Sweterlitsch, Jeff

    2012-01-01

    The Gas Analysis and Testing Laboratory is an integral part of the testing performed at the NASA Johnson Space Center. The Gas Analysis and Testing Laboratory is a high performance laboratory providing real time analytical instruments to support manned and unmanned testing. The lab utilizes precision gas chromatographs, gas analyzers and spectrophotometers to support the technology development programs within the NASA community. The Gas Analysis and Testing Laboratory works with a wide variety of customers and provides engineering support for user-specified applications in compressed gas, chemical analysis, general and research laboratory.

  5. Capability of the Gas Analysis and Testing Laboratory at the NASA Johnson Space Center

    NASA Technical Reports Server (NTRS)

    Broerman, Craig; Jimenez, Javier; Sweterlitsch, Jeff

    2011-01-01

    The Gas Analysis and Testing Laboratory is an integral part of the testing performed at the NASA Johnson Space Center. The Gas Analysis and Testing Laboratory is a high performance laboratory providing real time analytical instruments to support manned and unmanned testing. The lab utilizes precision gas chromatographs, gas analyzers and spectrophotometers to support the technology development programs within the NASA community. The Gas Analysis and Testing Laboratory works with a wide variety of customers and provides engineering support for user-specified applications in compressed gas, chemical analysis, general and research laboratory

  6. Improving Consistency in Large Laboratory Courses: A Design for a Standardized Practical Exam

    ERIC Educational Resources Information Center

    Chen, Xinnian; Graesser, Donnasue; Sah, Megha

    2015-01-01

    Laboratory courses serve as important gateways to science, technology, engineering, and mathematics education. One of the challenges in assessing laboratory learning is to conduct meaningful and standardized practical exams, especially for large multisection laboratory courses. Laboratory practical exams in life sciences courses are frequently…

  7. Disease surveillance system evaluation as a model for improved integration and standardization of the laboratory component in the Field Epidemiology and Laboratory Training Program (FELTP) curriculum worldwide.

    PubMed

    Rush, Thomas

    2012-11-01

    Integration of laboratory training into the Centers for Disease Control and Prevention's (CDC) Field Epidemiology Training Program (FETP) began in 2004 and has advanced the training of laboratory scientists worldwide on the basic principles of epidemiology, disease surveillance, and outbreak investigation. The laboratory component of the FE(L)TP training has traditionally been disease specific, revolving around classroom and bench training on laboratory methods, and field placement in areas where services are needed. There is however a need to improve the integration of epidemiology elements used in surveillance, outbreak investigation, and evaluation activities with specific measurable laboratory activities that could in turn impact the overall disease surveillance and response. A systematic and clear evaluation guideline for the laboratory components of disease surveillance systems alongside the corresponding epidemiological indicators can better identify, address, and mitigate weaknesses that may exist in the entire surveillance system, and also help to integrate and standardize the FE(L)TP curriculum content. The institution of laboratory Quality Management System principles linked to a comprehensive surveillance evaluation scheme will result in improved disease surveillance, response, and overall laboratory capacity over time.

  8. A Research Utilization Laboratory in a Comprehensive Rehabilitation Center. Final Report.

    ERIC Educational Resources Information Center

    Robinault, Isabel P.; Weisinger, Marvin

    The ICD Research Utilization Laboratory (ICD-RUL) at the Comprehensive Rehabilitation Center at Catholic University in Washington, D.C. acted as a facilitator for improving management practices of supervisors of vocationally impaired populations. Over a 10-year span, ICD-RUL developed two National Information Centers for disabled public assistance…

  9. Epidemiological, clinical and laboratory findings of infectious keratitis at Mansoura Ophthalmic Center, Egypt

    PubMed Central

    Badawi, Amani E; Moemen, Dalia; El-Tantawy, Nora L

    2017-01-01

    AIM To analyze the epidemiological, clinical and laboratory findings of infectious keratitis. METHODS A retrospective study on cases of infective keratitis, attended our institution from Mar. 2013 to Feb. 2015, was done at Mansoura Ophthalmic Center, Egypt. Corneal scrapings were performed and processed for direct microscopy and culture in appropriate media using standard laboratory protocols. RESULTS Out of 245 patients enrolled for study, 247 corneal scrapings were obtained. Ocular trauma was the most common predisposing factor (51.4%), followed by diabetes mellitus (15.1%). Cultures were positive in 110 scraping samples (44.5%): 45.5% samples had pure fungal infection, 40% had pure bacterial infections and 10% had mixed fungal and bacterial growths. Acanthamoeba was detected in 5 (4.5%) samples. The most common fungal pathogen was Aspergillus spp. (41%). The most common bacterial isolates were Staphylococcus aureus (38.2%) and Pseudomonas aeruginosa (21.8%). CONCLUSION Incidence of fungal keratitis is high in our region. Therapeutic approach can initially be based on clinical features and sensitivity/resistance patterns. Microbiological research should direct the antimicrobial treatment. Antibiotic resistance to fluoroquinolones and aminoglycosides is an important consideration. PMID:28149778

  10. 42 CFR 493.1445 - Standard; Laboratory director responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... assessment programs are established and maintained to assure the quality of laboratory services provided and... quality laboratory services for all aspects of test performance, which includes the preanalytic, analytic... methodologies selected have the capability of providing the quality of results required for patient care;...

  11. Emergency preparedness for genetics centers, laboratories, and patients: the Southeast Region Genetics Collaborative strategic plan.

    PubMed

    Andersson, Hans C; Perry, William; Bowdish, Bruce; Floyd-Browning, Phaidra

    2011-10-01

    Emergencies occur unpredictably and interrupt routine genetic care. The events after hurricanes Katrina and Rita have led to the recognition that a coherent plan is necessary to ensure continuity of operations for genetic centers and laboratories, including newborn screening. No geographic region is protected from the effects of a variety of potential emergencies. Regional and national efforts have begun to address the need for such preparedness, but a plan for ensuring continuity of operations by creating an emergency preparedness plan must be developed for each genetic center and laboratory, with attention to the interests of patients. This article describes the first steps in development of an emergency preparedness plan for individual centers.

  12. Multicenter Comparison of Laboratory Performance in Cytomegalovirus and Epstein-Barr Virus Viral Load Testing using International Standards

    PubMed Central

    Rychert, Jenna; Danziger-Isakov, Lara; Yen-Lieberman, Belinda; Storch, Gregory; Buller, Richard; Sweet, Stewart C.; Mehta, Aneesh K.; Cheeseman, Jennifer A.; Heeger, Peter; Rosenberg, Eric S.; Fishman, Jay A.

    2015-01-01

    Background Infections with cytomegalovirus (CMV) and Epstein Barr Virus (EBV) remain important in solid organ transplantation. Quantitative viral nucleic acid testing is a major advance to patient management. These assays are limited by a lack of standardization, resulting in viral load measurements that differ among clinical laboratories. The variability in viral load measurements makes interpretation of multicenter clinical trials data difficult. This study compares the current practices in CMV and EBV viral load testing at four large transplant centers participating in multicenter Clinical Trials in Organ Transplantation (CTOT/CTOTC). Methods Viral load testing was performed on well-defined viral preparations according to standard operating procedures at each site. Results Among centers, CMV viral load testing was accurate compared to WHO International Standards and within acceptable variation for this testing method. EBV viral load data were more variable and less accurate despite the use of international standards. Conclusions These data suggest that comparison of CMV, but not EBV, viral load measurements at these sites is possible using current assays and control standards. Standardization of these assays is facilitated by using the WHO International Standards and will allow comparison of viral load results among transplant centers. Assay standardization must be performed prior to initiation of multicenter trials. PMID:25303316

  13. 42 CFR 493.1443 - Standard; Laboratory director qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... laboratory director must— (1)(i) Be a doctor of medicine or doctor of osteopathy licensed to practice...; or (2) Be a doctor of medicine, a doctor of osteopathy or doctor of podiatric medicine licensed...

  14. 42 CFR 493.1443 - Standard; Laboratory director qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... laboratory director must— (1)(i) Be a doctor of medicine or doctor of osteopathy licensed to practice...; or (2) Be a doctor of medicine, a doctor of osteopathy or doctor of podiatric medicine licensed...

  15. 42 CFR 493.1405 - Standard; Laboratory director qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...; and (b) The laboratory director must— (1) (i) Be a doctor of medicine or doctor of osteopathy licensed... certification; or (2)(i) Be a doctor of medicine, doctor of osteopathy, or doctor of podiatric medicine...

  16. 42 CFR 493.1443 - Standard; Laboratory director qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... laboratory director must— (1)(i) Be a doctor of medicine or doctor of osteopathy licensed to practice...; or (2) Be a doctor of medicine, a doctor of osteopathy or doctor of podiatric medicine licensed...

  17. 42 CFR 493.1405 - Standard; Laboratory director qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...; and (b) The laboratory director must— (1) (i) Be a doctor of medicine or doctor of osteopathy licensed... certification; or (2)(i) Be a doctor of medicine, doctor of osteopathy, or doctor of podiatric medicine...

  18. 42 CFR 493.1405 - Standard; Laboratory director qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...; and (b) The laboratory director must— (1) (i) Be a doctor of medicine or doctor of osteopathy licensed... certification; or (2)(i) Be a doctor of medicine, doctor of osteopathy, or doctor of podiatric medicine...

  19. 42 CFR 493.1405 - Standard; Laboratory director qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., physical, or biological science or medical technology from an accredited institution; (ii) Have at least 2... medical education credit hours in laboratory practice commensurate with the director responsibilities... obtained during medical residency. (For example, physicians certified either in hematology or...

  20. 77 FR 16551 - Standards for Private Laboratory Analytical Packages and Introduction to Laboratory Related...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-21

    ... Introduction to Laboratory Related Portions of the Food Modernization Safety Act for Private Laboratory... and Introduction to Laboratory Related Portions of the Food Modernization Safety Act for Private... and an introduction to sections of the Food Safety Modernization Act of January 6, 2011, that...

  1. Illinois Occupational Skill Standards: Retail Garden Center Cluster.

    ERIC Educational Resources Information Center

    Illinois Occupational Skill Standards and Credentialing Council, Carbondale.

    These skill standards, developed through a consortium of educational and industry partners in Illinois, serve as guides to workforce preparation program providers to define content for their programs and to employers to establish the skills and standards necessary for job acquisition and performance. The skill standards include the following…

  2. A brave new animal for a brave new world: The British Laboratory Animals Bureau and the constitution of international standards of laboratory animal production and use, circa 1947-1968.

    PubMed

    Kirk, Robert G W

    2010-03-01

    In 1947 the Medical Research Council of Britain established the Laboratory Animals Bureau in order to develop national standards of animal production that would enable commercial producers better to provide for the needs of laboratory animal users. Under the directorship of William Lane-Petter, the bureau expanded well beyond this remit, pioneering a new discipline of "laboratory animal science" and becoming internationally known as a producer of pathogenically and genetically standardized laboratory animals. The work of this organization, later renamed the Laboratory Animals Centre, and of Lane-Petter did much to systematize worldwide standards for laboratory animal production and provision--for example, by prompting the formation of the International Committee on Laboratory Animals. This essay reconstructs how the bureau became an internationally recognized center of expertise and argues that standardization discourses within science are inherently internationalizing. It traces the dynamic co-constitution of standard laboratory animals alongside that of the identities of the users, producers, and regulators of laboratory animals. This process is shown to have brought into being a transnational community with shared conceptual understandings and material practices grounded in the materiality of the laboratory animal, conceived as an instrumental technology.

  3. 75 FR 9229 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-01

    ...-7299, 501-202-2783. (Formerly: Forensic Toxicology Laboratory Baptist Medical Center) Clinical... Affairs Medical Center, Forensic Toxicology Laboratory, 1 Veterans Drive, Minneapolis, MN 55417, 612-725...-747-3774. (Formerly: University of Texas Medical Branch, Clinical Chemistry Division; UTMB...

  4. The effects of calculator-based laboratories on standardized test scores

    NASA Astrophysics Data System (ADS)

    Stevens, Charlotte Bethany Rains

    Nationwide, the goal of providing a productive science and math education to our youth in today's educational institutions is centering itself around the technology being utilized in these classrooms. In this age of digital technology, educational software and calculator-based laboratories (CBL) have become significant devices in the teaching of science and math for many states across the United States. Among the technology, the Texas Instruments graphing calculator and Vernier Labpro interface, are among some of the calculator-based laboratories becoming increasingly popular among middle and high school science and math teachers in many school districts across this country. In Tennessee, however, it is reported that this type of technology is not regularly utilized at the student level in most high school science classrooms, especially in the area of Physical Science (Vernier, 2006). This research explored the effect of calculator based laboratory instruction on standardized test scores. The purpose of this study was to determine the effect of traditional teaching methods versus graphing calculator teaching methods on the state mandated End-of-Course (EOC) Physical Science exam based on ability, gender, and ethnicity. The sample included 187 total tenth and eleventh grade physical science students, 101 of which belonged to a control group and 87 of which belonged to the experimental group. Physical Science End-of-Course scores obtained from the Tennessee Department of Education during the spring of 2005 and the spring of 2006 were used to examine the hypotheses. The findings of this research study suggested the type of teaching method, traditional or calculator based, did not have an effect on standardized test scores. However, the students' ability level, as demonstrated on the End-of-Course test, had a significant effect on End-of-Course test scores. This study focused on a limited population of high school physical science students in the middle Tennessee

  5. 42 CFR 493.1407 - Standard; Laboratory director responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... testing; (2) Ensure that the physical plant and environmental conditions of the laboratory are appropriate... physical, chemical, and biological hazards; (3) Ensure that— (i) The test methodologies selected have the... functioning properly; (8) Ensure that reports of test results include pertinent information required...

  6. Economic Analysis of Requests for Laboratory Tests in Primary Health Care Centers

    PubMed Central

    Zunic, Lejla

    2012-01-01

    Introduction: Operation of the Primary health care center and Medical-biochemical laboratories depends on the number of performed laboratory tests. The number of unnecessary tests significantly affect the operation of health institutions. Material and methods: We analyzed the 1000 requests for laboratory tests at the Primary Health Care Centre in Gracanica from primary care units. Based on the requests for laboratory diagnostics advisable diagnoses from primary health care unit in the Primary Health Care Center (PHC) we made an economic analysis of the total required laboratory tests in the requests for laboratory diagnosis. Incorporating the economic analysis of laboratory tests in requests for laboratory diagnosis by doctors in primary health care (PHC) and the economic analysis of laboratory tests by the disease in primary health care. Results: The economic value of 5333 laboratory tests was 84 312 points (1 point is 0.80 KM). Of the total value of the index score requirements of GPs are 44, 1%, the requirement of family doctors account for 40% and requirements of other specialists make up 15, 9%.. Discussion: In the requests of the PHC units for laboratory tests are required all levels of services: urine, CBC, SE, glucose, bilirubine, ALT, AST, AF, CK, cholesterol, HDL chol., triglicerdes, creatinine, urea, uric acid, CRP, fibrinogen, calcium and phosphorus. The following requests are the most common laboratory tests: urine, CBC, blood glucose, cholesterol, triglycerides, aminotransferases, creatinine, urea. The doctors in family practice most often requested: blood glucose, urine, CBC, SE, TGL. , Chol., ALT, AST, creatinine and urea. General practitioners were demanding more cholesterol and triglycerides, and family medicine doctors were demanding less cholesterol and triglycerides and more often CRP, fibrinogen, ALT, AST, what from the level of economic cost analysis rises the issue whether this was justified? PMID:23322950

  7. Frequency standards from government laboratories over the next 25 years

    NASA Technical Reports Server (NTRS)

    Maleki, L.

    1994-01-01

    Based on a number of considerations including projected needs, current status, future trends, and status of key technologies, an attempt is made to project the future of government supported frequency standards development in the next 25 years.

  8. Accreditation Standards for University and College Counseling Centers.

    ERIC Educational Resources Information Center

    Boyd, Vivian; Hattauer, Edward; Brandel, Irvin W.; Buckles, Nancy; Davidshofer, Charles; Deakin, Spencer; Erskine, Charlene; Hurley, George; Locher, Linda; Piorkowski, Geraldine; Simono, R. B.; Spivack, James; Steel, Catherine M.

    2003-01-01

    The accreditation standards outlined in the article are used by the International Association of Counseling Services as the basis for the formal accreditation of college and university counseling programs throughout the United States, Canada, and Australia. They reflect the program elements and practice standards that are deemed essential in a…

  9. Applied human factors research at the NASA Johnson Space Center Human-Computer Interaction Laboratory

    NASA Technical Reports Server (NTRS)

    Rudisill, Marianne; Mckay, Timothy D.

    1990-01-01

    The applied human factors research program performed at the NASA Johnson Space Center's Human-Computer Interaction Laboratory is discussed. Research is conducted to advance knowledge in human interaction with computer systems during space crew tasks. In addition, the Laboratory is directly involved in the specification of the human-computer interface (HCI) for space systems in development (e.g., Space Station Freedom) and is providing guidelines and support for HCI design to current and future space missions.

  10. U.S. Geological Survey Standard Reference Sample Project: Performance Evaluation of Analytical Laboratories

    USGS Publications Warehouse

    Long, H. Keith; Daddow, Richard L.; Farrar, Jerry W.

    1998-01-01

    Since 1962, the U.S. Geological Survey (USGS) has operated the Standard Reference Sample Project to evaluate the performance of USGS, cooperator, and contractor analytical laboratories that analyze chemical constituents of environmental samples. The laboratories are evaluated by using performance evaluation samples, called Standard Reference Samples (SRSs). SRSs are submitted to laboratories semi-annually for round-robin laboratory performance comparison purposes. Currently, approximately 100 laboratories are evaluated for their analytical performance on six SRSs for inorganic and nutrient constituents. As part of the SRS Project, a surplus of homogeneous, stable SRSs is maintained for purchase by USGS offices and participating laboratories for use in continuing quality-assurance and quality-control activities. Statistical evaluation of the laboratories results provides information to compare the analytical performance of the laboratories and to determine possible analytical deficiences and problems. SRS results also provide information on the bias and variability of different analytical methods used in the SRS analyses.

  11. Highlighting High Performance: National Renewable Energy Laboratory's Visitors Center, Golden, Colorado

    SciTech Connect

    Burgert, S.

    2001-06-19

    The National Renewable Energy Laboratory Visitors Center, also known as the Dan Schaefer Federal Building, is a high-performance building located in Golden, Colorado. The 6,400-square-foot building incorporates passive solar heating, energy-efficient lighting, an evaporative cooling system, and other technologies to minimize energy costs and environmental impact. The Visitors Center displays a variety of interactive exhibits on energy efficiency and renewable energy, and the building includes an auditorium, a public reading room, and office space.

  12. Inter-laboratory variation in DNA damage using a standard comet assay protocol.

    PubMed

    Forchhammer, Lykke; Ersson, Clara; Loft, Steffen; Möller, Lennart; Godschalk, Roger W L; van Schooten, Frederik J; Jones, George D D; Higgins, Jennifer A; Cooke, Marcus; Mistry, Vilas; Karbaschi, Mahsa; Collins, Andrew R; Azqueta, Amaya; Phillips, David H; Sozeri, Osman; Routledge, Michael N; Nelson-Smith, Kirsty; Riso, Patrizia; Porrini, Marisa; Matullo, Giuseppe; Allione, Alessandra; Stępnik, Maciej; Steepnik, Maciej; Komorowska, Magdalena; Teixeira, João Paulo; Costa, Solange; Corcuera, Laura-Ana; López de Cerain, Adela; Laffon, Blanca; Valdiglesias, Vanessa; Møller, Peter

    2012-11-01

    There are substantial inter-laboratory variations in the levels of DNA damage measured by the comet assay. The aim of this study was to investigate whether adherence to a standard comet assay protocol would reduce inter-laboratory variation in reported values of DNA damage. Fourteen laboratories determined the baseline level of DNA strand breaks (SBs)/alkaline labile sites and formamidopyrimidine DNA glycosylase (FPG)-sensitive sites in coded samples of mononuclear blood cells (MNBCs) from healthy volunteers. There were technical problems in seven laboratories in adopting the standard protocol, which were not related to the level of experience. Therefore, the inter-laboratory variation in DNA damage was only analysed using the results from laboratories that had obtained complete data with the standard comet assay protocol. This analysis showed that the differences between reported levels of DNA SBs/alkaline labile sites in MNBCs were not reduced by applying the standard assay protocol as compared with the laboratory's own protocol. There was large inter-laboratory variation in FPG-sensitive sites by the laboratory-specific protocol and the variation was reduced when the samples were analysed by the standard protocol. The SBs and FPG-sensitive sites were measured in the same experiment, indicating that the large spread in the latter lesions was the main reason for the reduced inter-laboratory variation. However, it remains worrying that half of the participating laboratories obtained poor results using the standard procedure. This study indicates that future comet assay validation trials should take steps to evaluate the implementation of standard procedures in participating laboratories.

  13. Meeting Academic Standards through Peer Dialogue at Literacy Centers

    ERIC Educational Resources Information Center

    Maurer, Caroline

    2010-01-01

    Literacy centers are widely used by teachers seen as being effective in promoting literacy (Pressley, Rankin, & Yokoi, 2000); yet little research has been completed on how or why they are effective. Based on the social cultural constructivist theory posited by Vygotsky (1978), and research theories of Dyson (1993), the peer dialogue at the…

  14. Scientific involvement in Skylab by the Space Sciences Laboratory of the Marshall Space Flight Center

    NASA Technical Reports Server (NTRS)

    Winkler, C. E. (Editor)

    1973-01-01

    The involvement of the Marshall Space Flight Center's Space Sciences Laboratory in the Skylab program from the early feasibility studies through the analysis and publication of flight scientific and technical results is described. This includes mission operations support, the Apollo telescope mount, materials science/manufacturing in space, optical contamination, environmental and thermal criteria, and several corollary measurements and experiments.

  15. FJ44 Turbofan Engine Test at NASA Glenn Research Center's Aero-Acoustic Propulsion Laboratory

    NASA Technical Reports Server (NTRS)

    Lauer, Joel T.; McAllister, Joseph; Loew, Raymond A.; Sutliff, Daniel L.; Harley, Thomas C.

    2009-01-01

    A Williams International FJ44-3A 3000-lb thrust class turbofan engine was tested in the NASA Glenn Research Center s Aero-Acoustic Propulsion Laboratory. This report presents the test set-up and documents the test conditions. Farfield directivity, in-duct unsteady pressures, duct mode data, and phased-array data were taken and are reported separately.

  16. Center for Materials Science, Los Alamos National Laboratory. Status report, October 1, 1990--September 30, 1991

    SciTech Connect

    Parkin, D.M.; Boring, A.M.

    1991-10-01

    This report summarizes the progress of the Center for Materials Science (CMS) from October 1, 1990 to September 30, 1991, and is the nineth such annual report. It has been a year of remarkable progress in building the programs of the Center. The extent of this progress is described in detail. The CMS was established to enhance the contribution of materials science and technology to the Laboratory`s defense, energy and scientific missions, and the Laboratory. In carrying out these responsibilities it has accepted four demanding missions: (1) Build a core group of highly rated, established materials scientists and solid state physicists. (2) Promote and support top quality, interdisciplinary materials research programs at Los Alamos. (3) Strengthen the interactions of materials science and Los Alamos with the external materials science community. and (4) Establish and maintain modern materials research facilities in a readily accessible, central location.

  17. The Synergistic Attributes of Library Media Center Standards

    ERIC Educational Resources Information Center

    Misakian, Jo Ellen Priest

    2006-01-01

    Designing curricula around the standards, with clearly delineated strategies, expectations, and evaluative procedures, is thought to assure that growth in student achievement may be tracked. While this process can sometimes be nebulous, one thing is certain: clearly understanding what is involved in reaching a degree of excellence and determining…

  18. 76 FR 9578 - Clinical Laboratory Improvement Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-18

    ... HUMAN SERVICES Centers for Disease Control and Prevention Clinical Laboratory Improvement Advisory... Additional Information: Nancy Anderson, Chief, Laboratory Practice Standards Branch, Division of Laboratory Science and Standards, Laboratory Science, Policy and Practice Program Office, Office of...

  19. National Renewable Energy Laboratory's Hydrogen Technologies and Systems Center is Helping to Facilitate the Transition to a New Energy Future

    SciTech Connect

    Not Available

    2011-01-01

    The Hydrogen Technologies and Systems Center (HTSC) at the U.S. Department of Energy's (DOE) National Renewable Energy Laboratory (NREL) uses a systems engineering and integration approach to hydrogen research and development to help the United States make the transition to a new energy future - a future built on diverse and abundant domestic renewable resources and integrated hydrogen systems. Research focuses on renewable hydrogen production, delivery, and storage; fuel cells and fuel cell manufacturing; technology validation; safety, codes, and standards; analysis; education; and market transformation. Hydrogen can be used in fuel cells to power vehicles and to provide electricity and heat for homes and offices. This flexibility, combined with our increasing demand for energy, opens the door for hydrogen power systems. HTSC collaborates with DOE, other government agencies, industry, communities, universities, national laboratories, and other stakeholders to promote a clean and secure energy future.

  20. Systems integration for the Kennedy Space Center (KSC) Robotics Applications Development Laboratory (RADL)

    NASA Technical Reports Server (NTRS)

    Davis, V. Leon; Nordeen, Ross

    1988-01-01

    A laboratory for developing robotics technology for hazardous and repetitive Shuttle and payload processing activities is discussed. An overview of the computer hardware and software responsible for integrating the laboratory systems is given. The center's anthropomorphic robot is placed on a track allowing it to be moved to different stations. Various aspects of the laboratory equipment are described, including industrial robot arm control, smart systems integration, the supervisory computer, programmable process controller, real-time tracking controller, image processing hardware, and control display graphics. Topics of research include: automated loading and unloading of hypergolics for space vehicles and payloads; the use of mobile robotics for security, fire fighting, and hazardous spill operations; nondestructive testing for SRB joint and seal verification; Shuttle Orbiter radiator damage inspection; and Orbiter contour measurements. The possibility of expanding the laboratory in the future is examined.

  1. Automating the Analytical Laboratories Section, Lewis Research Center, National Aeronautics and Space Administration: A feasibility study

    NASA Technical Reports Server (NTRS)

    Boyle, W. G.; Barton, G. W.

    1979-01-01

    The feasibility of computerized automation of the Analytical Laboratories Section at NASA's Lewis Research Center was considered. Since that laboratory's duties are not routine, the automation goals were set with that in mind. Four instruments were selected as the most likely automation candidates: an atomic absorption spectrophotometer, an emission spectrometer, an X-ray fluorescence spectrometer, and an X-ray diffraction unit. Two options for computer automation were described: a time-shared central computer and a system with microcomputers for each instrument connected to a central computer. A third option, presented for future planning, expands the microcomputer version. Costs and benefits for each option were considered. It was concluded that the microcomputer version best fits the goals and duties of the laboratory and that such an automted system is needed to meet the laboratory's future requirements.

  2. NATIONAL ENVIRONMENTAL LABORATORY ACCREDITATION CONFERENCE; CONSTITUTION, BYLAWS AND STANDARDS: APPROVED MAY 25, 2001

    EPA Science Inventory

    The principles and operating procedures for the National Environmental Laboratory Accreditation Conference (NELAC) are contained in the NELAC Constitution and Bylaws. The major portion of this document (standards) contains detailed requirements for accrediting environmental labo...

  3. Report on the Project for Establishment of the Standardized Korean Laboratory Terminology Database, 2015

    PubMed Central

    Lee, Kap-No

    2017-01-01

    The National Health Information Standards Committee was established in 2004 in Korea. The practical subcommittee for laboratory test terminology was placed in charge of standardizing laboratory medicine terminology in Korean. We aimed to establish a standardized Korean laboratory terminology database, Korea-Logical Observation Identifier Names and Codes (K-LOINC) based on former products sponsored by this committee. The primary product was revised based on the opinions of specialists. Next, we mapped the electronic data interchange (EDI) codes that were revised in 2014, to the corresponding K-LOINC. We established a database of synonyms, including the laboratory codes of three reference laboratories and four tertiary hospitals in Korea. Furthermore, we supplemented the clinical microbiology section of K-LOINC using an alternative mapping strategy. We investigated other systems that utilize laboratory codes in order to investigate the compatibility of K-LOINC with statistical standards for a number of tests. A total of 48,990 laboratory codes were adopted (21,539 new and 16,330 revised). All of the LOINC synonyms were translated into Korean, and 39,347 Korean synonyms were added. Moreover, 21,773 synonyms were added from reference laboratories and tertiary hospitals. Alternative strategies were established for mapping within the microbiology domain. When we applied these to a smaller hospital, the mapping rate was successfully increased. Finally, we confirmed K-LOINC compatibility with other statistical standards, including a newly proposed EDI code system. This project successfully established an up-to-date standardized Korean laboratory terminology database, as well as an updated EDI mapping to facilitate the introduction of standard terminology into institutions. PMID:28244299

  4. Report on the Project for Establishment of the Standardized Korean Laboratory Terminology Database, 2015.

    PubMed

    Jung, Bo Kyeung; Kim, Jeeyong; Cho, Chi Hyun; Kim, Ju Yeon; Nam, Myung Hyun; Shin, Bong Kyung; Rho, Eun Youn; Kim, Sollip; Sung, Heungsup; Kim, Shinyoung; Ki, Chang Seok; Park, Min Jung; Lee, Kap No; Yoon, Soo Young

    2017-04-01

    The National Health Information Standards Committee was established in 2004 in Korea. The practical subcommittee for laboratory test terminology was placed in charge of standardizing laboratory medicine terminology in Korean. We aimed to establish a standardized Korean laboratory terminology database, Korea-Logical Observation Identifier Names and Codes (K-LOINC) based on former products sponsored by this committee. The primary product was revised based on the opinions of specialists. Next, we mapped the electronic data interchange (EDI) codes that were revised in 2014, to the corresponding K-LOINC. We established a database of synonyms, including the laboratory codes of three reference laboratories and four tertiary hospitals in Korea. Furthermore, we supplemented the clinical microbiology section of K-LOINC using an alternative mapping strategy. We investigated other systems that utilize laboratory codes in order to investigate the compatibility of K-LOINC with statistical standards for a number of tests. A total of 48,990 laboratory codes were adopted (21,539 new and 16,330 revised). All of the LOINC synonyms were translated into Korean, and 39,347 Korean synonyms were added. Moreover, 21,773 synonyms were added from reference laboratories and tertiary hospitals. Alternative strategies were established for mapping within the microbiology domain. When we applied these to a smaller hospital, the mapping rate was successfully increased. Finally, we confirmed K-LOINC compatibility with other statistical standards, including a newly proposed EDI code system. This project successfully established an up-to-date standardized Korean laboratory terminology database, as well as an updated EDI mapping to facilitate the introduction of standard terminology into institutions.

  5. 46 CFR 159.010-3 - Independent laboratory: Standards for acceptance.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 6 2010-10-01 2010-10-01 false Independent laboratory: Standards for acceptance. 159.010-3 Section 159.010-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT... (5) Not advertise or promote the manufacturer's equipment or material that the laboratory...

  6. 7 CFR 91.37 - Standard hourly fee rate for laboratory testing, analysis, and other services.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Standard hourly fee rate for laboratory testing, analysis, and other services. 91.37 Section 91.37 Agriculture Regulations of the Department of Agriculture... AGRICULTURE (CONTINUED) COMMODITY LABORATORY TESTING PROGRAMS SERVICES AND GENERAL INFORMATION Fees...

  7. 7 CFR 91.37 - Standard hourly fee rate for laboratory testing, analysis, and other services.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Standard hourly fee rate for laboratory testing, analysis, and other services. 91.37 Section 91.37 Agriculture Regulations of the Department of Agriculture... AGRICULTURE (CONTINUED) COMMODITY LABORATORY TESTING PROGRAMS SERVICES AND GENERAL INFORMATION Fees...

  8. Inter-laboratory validation of standardized method to determine permeability of plastic films

    Technology Transfer Automated Retrieval System (TEKTRAN)

    To support regulations controlling soil fumigation, we are standardizing the laboratory method we developed to measure the permeability of plastic films to fumigant vapors. The method was validated using an inter-laboratory comparison with 7 participants. Each participant evaluated the mass transfer...

  9. Comparison of nonmesonic hypernuclear decay rates computed in laboratory and center-of-mass coordinates

    SciTech Connect

    De Conti, C.; Barbero, C.; Galeão, A. P.; Krmpotić, F.

    2014-11-11

    In this work we compute the one-nucleon-induced nonmesonic hypernuclear decay rates of {sub Λ}{sup 5}He, {sub Λ}{sup 12}C and {sub Λ}{sup 13}C using a formalism based on the independent particle shell model in terms of laboratory coordinates. To ascertain the correctness and precision of the method, these results are compared with those obtained using a formalism in terms of center-of-mass coordinates, which has been previously reported in the literature. The formalism in terms of laboratory coordinates will be useful in the shell-model approach to two-nucleon-induced transitions.

  10. Los Alamos National Laboratory standard nuclear material container

    SciTech Connect

    Stone, Timothy A

    2009-01-01

    The shut down of United States (U.S.) nuclear-weapons production activities in the early 1990s left large quantities of nuclear materials throughout the U.S. Department of Energy (DOE) complex in forms not intended for long-term storage. In May 1994, the Defense Nuclear Facilities Safety Board (DNFSB) issued Recommendation 94-1, which called for the stabilization and disposition of 'thousands of containers of plutonium-bearing liquids and solids' in the DOE complex, including LANL in the nuclear-weapons-manufacturing pipeline when manufacturing ended. This resulted in the development of the 3013 standard with container requirements for long term storage (up to 50 years). A follow on was the Criteria For Interim Storage of Plutonium Bearing Materials, Charles B. Curtis, in 1996 to address storage other than the 3013 standard for shorter time frames. In January 2000, the DNFSB issued Recommendation 2000-1, which stated the need for LANL to repackage 'about one ton of plutonium metal and oxide,' declared excess to Defense Program (DP) needs. The DNFSB recommended that LANL 'stabilize and seal within welded containers with an inert atmosphere the plutonium oxides ... which are not yet in states conforming to the long-term storage envisaged by DOE-STD-3013,' and that they '... enclose existing and newly-generated legacy plutonium metal in sealed containers with an inert atmosphere,' and 'remediate and/or safely store the various residues.' Recommendation 2000-1, while adding to the number of items needing remediation, also reiterated the need to address remaining items from 1994-1 in a timely fashion. Since timetables slipped, the DNFSB recommended that the Complex 'prioritize and schedule tasks according to the consideration of risks.' In March 2005, the DNFSB issued Recommendation 2005-1. This recommendation addresses the need for a consistent set of criteria across the DOE complex for the interim storage of nuclear material packaged outside an engineered barrier. The

  11. [Activities and responsibilities of workers in embryologic and andrologic laboratories in assisted reproduction centers].

    PubMed

    Záková, J; Trávník, P; Malenovská, A; Hűttelová, R

    2013-11-01

    This paper presents the current status and rules for the laboratory staff activities and their competences in the centers of assisted reproduction. The rules were processed by the members of the Association of Reproductive Embryology (ARE) committee under the current legislation. Committee members of the Czech Sterility and Assisted Reproduction Society and Czech Gynecology and Obstetric Society approved these rules as obligatory for assisted reproduction centres in Czech Republic.

  12. NASA Glenn Research Center's Fuel Cell Stack, Ancillary and System Test and Development Laboratory

    NASA Technical Reports Server (NTRS)

    Loyselle, Patricia L.; Prokopius, Kevin P.; Becks, Larry A.; Burger, Thomas H.; Dick, Joseph F.; Rodriguez, George; Bremenour, Frank; Long, Zedock

    2011-01-01

    At the NASA Glenn Research Center, a fully operational fuel cell test and evaluation laboratory is available which is capable of evaluating fuel cell components and systems for future NASA missions. Components and subsystems of various types can be operated and monitored under a variety of conditions utilizing different reactants. This fuel cell facility can test the effectiveness of various component and system designs to meet NASA's needs.

  13. Spectroscopy and astronomy: H3+ from the laboratory to the Galactic center.

    PubMed

    Oka, Takeshi

    2011-01-01

    Since the serendipitous discovery of the Fraunhofer spectrum in the Sun in 1814 which initiated spectroscopy and astrophysics, spectroscopy developed hand in hand with astronomy. I discuss my own work on the infrared spectrum of H3+ from its discovery in the laboratory in 1980, in interstellar space in 1996, to recent studies in the Galactic center as an example of astronomical spectroscopy. Its spin-off, the spectroscopy of simple molecular ions, is also briefly discussed.

  14. National laboratories` capabilities summaries for the DOE Virtual Center for Multiphase Dynamics (VCMD)

    SciTech Connect

    Joyce, E.L.

    1997-03-01

    The Virtual Center For Multiphase Dynamics (VCMD) integrates and develops the resources of industry, government, academia, and professional societies to enable reliable analysis in multiphase computational fluid dynamics. The primary means of the VCMD focus will be by the creation, support, and validation of a computerized simulation capability for multiphase flow and multiphase flow applications. This paper briefly describes the capabilities of the National Laboratories in this effort.

  15. CIRCE, the Proposed Coherent Infrared Center at the LawrenceBerkeley National Laboratory

    SciTech Connect

    Byrd, John M.; Martin, Michael M.; Sannibale, Fernando

    2005-07-12

    At the Advanced Light Source (ALS) of the Lawrence Berkeley National Laboratory (LBNL), we are proposing the construction of CIRCE (Coherent InfraRed Center), a ring-based photon source completely optimized for the generation of coherent synchrotron radiation (CSR) in the terahertz frequency range [1]. CIRCE exploits the full complement of the CSR-production mechanisms presently available for obtaining top performance, including a photon flux exceeding by more than nine orders of magnitude that of existing ''conventional'' broadband terahertz sources.

  16. 40 CFR 262.103 - What is the scope of the laboratory environmental management standard?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 27 2013-07-01 2013-07-01 false What is the scope of the laboratory environmental management standard? 262.103 Section 262.103 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS...

  17. Creating Cost-Effective DNA Size Standards for Use in Teaching and Research Laboratories

    ERIC Educational Resources Information Center

    Shultz, Jeff

    2011-01-01

    I have devised a method with which a molecular size standard can be readily manufactured using Lambda DNA and PCR. This method allows the production of specific sized DNA fragments and is easily performed in a standard molecular biology laboratory. The material required to create these markers can also be used to provide a highly robust and…

  18. 40 CFR 262.103 - What is the scope of the laboratory environmental management standard?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 26 2011-07-01 2011-07-01 false What is the scope of the laboratory environmental management standard? 262.103 Section 262.103 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS...

  19. 40 CFR 262.103 - What is the scope of the laboratory environmental management standard?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false What is the scope of the laboratory environmental management standard? 262.103 Section 262.103 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS...

  20. Public health microbiology in Germany: 20 years of national reference centers and consultant laboratories.

    PubMed

    Beermann, Sandra; Allerberger, Franz; Wirtz, Angela; Burger, Reinhard; Hamouda, Osamah

    2015-10-01

    In 1995, in agreement with the German Federal Ministry of Health, the Robert Koch Institute established a public health microbiology system consisting of national reference centers (NRCs) and consultant laboratories (CLs). The goal was to improve the efficiency of infection protection by advising the authorities on possible measures and to supplement infectious disease surveillance by monitoring selected pathogens that have high public health relevance. Currently, there are 19 NRCs and 40 CLs, each appointed for three years. In 2009, an additional system of national networks of NRCs and CLs was set up in order to enhance effectiveness and cooperation within the national reference laboratory system. The aim of these networks was to advance exchange in diagnostic methods and prevention concepts among reference laboratories and to develop geographic coverage of services. In the last two decades, the German public health laboratory reference system coped with all major infectious disease challenges. The European Union and the European Centre for Disease Prevention and Control (ECDC) are considering implementing a European public health microbiology reference laboratory system. The German reference laboratory system should be well prepared to participate actively in this upcoming endeavor.

  1. Multi-laboratory testing of a screening method for world trade center (WTC) collapse dust.

    PubMed

    Rosati, Jacky A; Bern, Amy M; Willis, Robert D; Blanchard, Fredrick T; Conner, Teri L; Kahn, Henry D; Friedman, David

    2008-02-15

    The September 11, 2001 attack on the World Trade Center (WTC) covered a large area of downtown New York City with dust and debris. This paper describes the testing of an analytical method designed to evaluate whether sampled dust contains dust that may have originated from the collapse of the WTC. Using dust samples collected from locations affected and not affected (referred to as 'background' locations) by the collapse, a scanning electron microscopy (SEM) analysis method was developed to screen for three materials that are believed to be present in large quantities in WTC dusts: slag wool, concrete, and gypsum. An inter-laboratory evaluation of the method was implemented by having eight laboratories analyze a number of 'blind' dust samples, consisting of confirmed background dust and confirmed background dust spiked with varying amounts of dust affected by the WTC collapse. The levels of gypsum and concrete in the spiked samples were indistinguishable from the levels in the background samples. Measurements of slag wool in dust demonstrated potential for distinguishing between spiked and background samples in spite of considerable within and between laboratory variability. Slag wool measurements appear to be sufficiently sensitive to distinguish dust spiked with 5% WTC-affected dust from 22 out of 25 background dust samples. Additional development work and inter-laboratory testing of the slag wool component will be necessary to improve the precision and accuracy of the method and reduce inter- and intra-laboratory variability from levels observed in the inter-laboratory evaluation.

  2. Ebola Virus Diagnostics: The US Centers for Disease Control and Prevention Laboratory in Sierra Leone, August 2014 to March 2015.

    PubMed

    Flint, Mike; Goodman, Christin H; Bearden, Scott; Blau, Dianna M; Amman, Brian R; Basile, Alison J; Belser, Jessica A; Bergeron, Éric; Bowen, Michael D; Brault, Aaron C; Campbell, Shelley; Chakrabarti, Ayan K; Dodd, Kimberly A; Erickson, Bobbie R; Freeman, Molly M; Gibbons, Aridth; Guerrero, Lisa W; Klena, John D; Lash, R Ryan; Lo, Michael K; McMullan, Laura K; Momoh, Gbetuwa; Massally, James L; Goba, Augustine; Paddock, Christopher D; Priestley, Rachael A; Pyle, Meredith; Rayfield, Mark; Russell, Brandy J; Salzer, Johanna S; Sanchez, Angela J; Schuh, Amy J; Sealy, Tara K; Steinau, Martin; Stoddard, Robyn A; Taboy, Céline; Turnsek, Maryann; Wang, David; Zemtsova, Galina E; Zivcec, Marko; Spiropoulou, Christina F; Ströher, Ute; Towner, Jonathan S; Nichol, Stuart T; Bird, Brian H

    2015-10-01

    In August 2014, the Viral Special Pathogens Branch of the US Centers for Disease Control and Prevention established a field laboratory in Sierra Leone in response to the ongoing Ebola virus outbreak. Through March 2015, this laboratory tested >12 000 specimens from throughout Sierra Leone. We describe the organization and procedures of the laboratory located in Bo, Sierra Leone.

  3. The evaluation of hospital laboratory information management systems based on the standards of the American National Standard Institute

    PubMed Central

    Isfahani, Sakineh Saghaeiannejad; Khajouei, Reza; Jahanbakhsh, Maryan; Mirmohamadi, Mahboubeh

    2014-01-01

    Introduction: Nowadays, modern laboratories are faced with a huge volume of information. One of the goals of the Laboratory Information Management System (LIMS) is to assist in the management of the information generated in the laboratory. This study intends to evaluate the LIMS based on the standards of the American National Standard Institute (ANSI). Materials and Methods: This research is a descriptive–analytical study, which had been conducted in 2011, on the LIMSs in use, in the teaching and private hospitals in Isfahan. The data collecting instrument was a checklist, which was made by evaluating three groups of information components namely: ‘System capabilities’, ‘work list functions,’ and ‘reporting’ based on LIS8-A. Data were analyzed using the SPSS 20. Data were analyzed using (relative) frequency, percentage. To compare the data the following statistical tests were used: Leven test, t-test, and Analysis of Variance (ANOVA). Results: The results of the study indicated that the LIMS had a low conformity (30%) with LIS8-A (P = 0.001), with no difference between teaching and private hospitals (P = 0.806). The ANOVA revealed that in terms of conformity with the LIS8-A standard, there was a significant difference between the systems produced by different vendors (P = 0.023). According to the results, a Kowsar system with more than %57 conformity in the three groups of information components had a better conformity to the standard, compared to the other systems. Conclusions: This study indicated that none of the LIMSs had a good conformity to the standard. It seems that system providers did not pay sufficient attention to many of the information components required by the standards when designing and developing their systems. It was suggested that standards from certified organizations and institutions be followed in the design and development process of health information systems. PMID:25077154

  4. 78 FR 42084 - Electronic Study Data Submission; Data Standard Support; Availability of the Center for Drug...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-15

    ... HUMAN SERVICES Food and Drug Administration Electronic Study Data Submission; Data Standard Support; Availability of the Center for Drug Evaluation and Research Data Standards Program Documents AGENCY: Food and...) of the Food and Drug Administration (FDA) is announcing the availability of the CDER Data...

  5. 75 FR 75485 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-03

    ...-Toxicology Laboratory, 11401 I-30, Little Rock, AR 72209-7056. 501-202-2783. (Formerly: Forensic Toxicology...-5295/800-950-5295. ] Minneapolis Veterans Affairs Medical Center, Forensic Toxicology Laboratory, 1..., Clinical Chemistry Division; UTMB Pathology-Toxicology Laboratory). Pacific Toxicology Laboratories,...

  6. 75 FR 16813 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-02

    ...-Toxicology Laboratory, 9601 I-630, Exit 7, Little Rock, AR 72205-7299, 501-202-2783, (Formerly: Forensic...-5295/800-950-5295; Minneapolis Veterans Affairs Medical Center, Forensic Toxicology Laboratory, 1..., Clinical Chemistry Division; UTMB Pathology-Toxicology Laboratory); Pacific Toxicology Laboratories,...

  7. Space and Missile Systems Center Standard: Test Requirements for Ground Systems

    DTIC Science & Technology

    2013-09-30

    changes, additions, deletions, etc.) and any pertinent data that may be of use in improving this standard should be forwarded to the following addressee... using the Standardization Document Improvement Proposal appearing at the end of this document or by letter: Division Chief, SMC/ENE SPACE AND...MISSILE SYSTEMS CENTER Air Force Space Command 483 N. Aviation Blvd. El Segundo, CA 90245 4. This standard has been approved for use on all Space and

  8. Standardization in laboratory medicine: Adoption of common reference intervals to the Croatian population

    PubMed Central

    Flegar-Meštrić, Zlata; Perkov, Sonja; Radeljak, Andrea

    2016-01-01

    Considering the fact that the results of laboratory tests provide useful information about the state of health of patients, determination of reference value is considered an intrinsic part in the development of laboratory medicine. There are still huge differences in the analytical methods used as well as in the associated reference intervals which could consequently significantly affect the proper assessment of patient health. In a constant effort to increase the quality of patients’ care, there are numerous international initiatives for standardization and/or harmonization of laboratory diagnostics in order to achieve maximum comparability of laboratory test results and improve patient safety. Through the standardization and harmonization processes of analytical methods the ability to create unique reference intervals is achieved. Such reference intervals could be applied globally in all laboratories using methods traceable to the same reference measuring system and analysing the biological samples from the populations with similar socio-demographic and ethnic characteristics. In this review we outlined the results of the harmonization processes in Croatia in the field of population based reference intervals for clinically relevant blood and serum constituents which are in accordance with ongoing activity for worldwide standardization and harmonization based on traceability in laboratory medicine. PMID:27019800

  9. Expansion of the Idaho National Engineering Laboratory Research Center: Environmental assessment

    SciTech Connect

    Not Available

    1994-03-01

    The US Department of Energy (DOE) proposes to expand and upgrade facilities at the Idaho National Engineering Laboratory (INEL) Research Center (IRC) by constructing a research laboratory addition on the northeast corner of existing laboratory building; upgrading the fume hood system in the existing laboratory building; and constructing a hazardous waste handling facility and a chemical storage building. The DOE also proposes to expand the capabilities of biotechnology research programs by increasing use of radiolabeled compounds to levels in excess of current facility limits for three radionuclides (carbon-14, sulfur-35, and phosphorus-32). This Environmental assessment identifies the need for the new facilities, describes the proposed projects and environmental setting, and evaluates the potential environmental effects. Impacts associated with current operation are discussed and established as a baseline. Impacts associated with the proposed action and cumulative impacts are described against this background. Alternatives to the proposed action (No action; Locating proposed facilities at a different site) are discussed and a list of applicable regulations is provided. The no action alternative is continuation of existing operations at existing levels as described in Section 4 of this EA. Proposed facilities could be constructed at a different location, but these facilities would not be useful or practical since they are needed to provide a support function for IRC operations. Further, the potential environmental impacts would not be reduced if a different site was selected.

  10. Activities of the Japanese space weather forecast center at Communications Research Laboratory.

    PubMed

    Watari, Shinichi; Tomita, Fumihiko

    2002-12-01

    The International Space Environment Service (ISES) is an international organization for space weather forecasts and belongs to the International Union of Radio Science (URSI). There are eleven ISES forecast centers in the world, and Communications Research Laboratory (CRL) runs the Japanese one. We make forecasts on the space environment and deliver them over the phones and through the Internet. Our forecasts could be useful for human activities in space. Currently solar activity is near maximum phase of the solar cycle 23. We report the several large disturbances of space environment occurred in 2001, during which low-latitude auroras were observed several times in Japan.

  11. Development Of International Data Standards For The COSMOS/PEER-LL Virtual Data Center

    NASA Astrophysics Data System (ADS)

    Swift, J. N.

    2005-12-01

    The COSMOS -PEER Lifelines Project 2L02 completed a Pilot Geotechnical Virtual Data Center (GVDC) system capable of both archiving geotechnical data and of disseminating data from multiple linked geotechnical databases. The Pilot GVDC system links geotechnical databases of four organizations: the California Geological Survey, Caltrans, PG&E, and the U. S. Geological Survey The System was presented and reviewed in the COSMOS-PEER Lifelines workshop on June 21 - 23, 2004, which was co-sponsored by the Federal Highway Administration (FHWA) and included participation by the United Kingdom Highways Agency (UKHA) , the Association of Geotechnical and Geoenvironmental Specialists in the United Kingdom (AGS), the United States Army Corp of Engineers (USACOE), Caltrans, United States Geological Survey (USGS), California Geological Survey (CGS), a number of state Departments of Transportation (DOTs), county building code officials, and representatives of academic institutions and private sector geotechnical companies. As of February 2005 COSMOS-PEER Lifelines Project 2L03 is currently funded to accomplish the following tasks: 1) expand the Pilot GVDC Geotechnical Data Dictionary and XML Schema to include data definitions and structures to describe in-situ measurements such as shear wave velocity profiles, and additional laboratory geotechnical test types; 2) participate in an international cooperative working group developing a single geotechnical data exchange standard that has broad international acceptance; and 3) upgrade the GVDC system to support corresponding exchange standard data dictionary and schema improvements. The new geophysical data structures being developed will include PS-logs, downhole geophysical logs, cross-hole velocity data, and velocity profiles derived using surface waves. A COSMOS-PEER Lifelines Geophysical Data Dictionary Working Committee constituted of experts in the development of data dictionary standards and experts in the specific data to be

  12. DOE standard: The Department of Energy Laboratory Accreditation Program for radiobioassay

    SciTech Connect

    1998-12-01

    This technical standard describes the US Department of Energy Laboratory Accreditation Program (DOELAP) for Radiobioassay, for use by the US Department of Energy (DOE) and DOE Contractor radiobioassay programs. This standard is intended to be used in conjunction with the general administrative technical standard that describes the overall DOELAP accreditation process--DOE-STD-1111-98, Department of Energy Laboratory Accreditation Program Administration. This technical standard pertains to radiobioassay service laboratories that provide either direct or indirect (in vivo or in vitro) radiobioassay measurements in support of internal dosimetry programs at DOE facilities or for DOE and DOE contractors. Similar technical standards have been developed for other DOELAP dosimetry programs. This program consists of providing an accreditation to DOE radiobioassay programs based on successful completion of a performance-testing process and an on-site evaluation by technical experts. This standard describes the technical requirements and processes specific to the DOELAP Radiobioassay Accreditation Program as required by 10 CFR 835 and as specified generically in DOE-STD-1111-98.

  13. Preparation, control, and use of standard operating procedures in a space simulation laboratory

    NASA Technical Reports Server (NTRS)

    Parish, R. P., Jr.

    1975-01-01

    The degree of success in the operation of a space simulation laboratory is a direct function of the role of its standard operating procedures. Their proper use in a thermal vacuum test effects a wellrun test program. Preparation and procedure control are discussed.

  14. NATIONAL ENVIRONMENTAL LABORATORY ACCREDITATION CONFERENCE: CONSTITUTION, BYLAWS AND STANDARDS; APPROVED JUNE 2000

    EPA Science Inventory

    As Director of the Environmental Protection Agency's National Environmental
    Laboratory Accreditation Program (NELAP), I offer my sincere appreciation to the many individuals who worked on the 2000 revision of the NELAC standards. I would like to give special recognition to th...

  15. The Picatinny Technology Transfer Innovation Center: A business incubator concept adapted to federal laboratory technology transfer

    SciTech Connect

    Wittig, T.; Greenfield, J.

    1996-10-01

    In recent years, the US defense industrial base spawned the aerospace industry, among other successes, and served as the nation`s technology seed bed. However, as the defense industrial base shrinks and public and private resources become scarcer, the merging of the commercial and defense communities becomes necessary to maintain national technological competencies. Cooperative efforts such as technology transfer provide an attractive, cost-effective, well-leveraged alternative to independently funded research and development (R and D). The sharing of knowledge, resources, and innovation among defense contractors and other public sector firms, academia, and other organizations has become exceedingly attractive. Recent legislation involving technology transfer provides for the sharing of federal laboratory resources with the private sector. The Army Research, Development and Engineering Center (ARDEC), Picatinny Arsenal, NJ, a designer of weapons systems, is one of the nation`s major laboratories with this requirement. To achieve its important technology transfer mission, ARDEC reviewed its capabilities, resources, intellectual property, and products with commercial potential. The purpose of the review was to develop a viable plan for effecting a technology transfer cultural change within the ARDEC, Picatinny Arsenal and with the private sector. This report highlights the issues identified, discussed, and resolved prior to the transformation of a temporarily vacant federal building on the Picatinny installation into a business incubator. ARDEC`s discussions and rationale for the decisions and actions that led to the implementation of the Picatinny Technology Transfer Innovation Center are discussed.

  16. Update on current concepts and meanings in laboratory medicine --Standardization, traceability and harmonization.

    PubMed

    Greenberg, Neil

    2014-05-15

    An increasingly important quality objective in laboratory medicine is ensuring the equivalence of test results among different measurement procedures, different laboratories and health care systems, over time. In recent years, interest in sharing a single patient's clinical laboratory data, regardless of where the measurements are performed, has moved out of the domain of the scientific community and spilled over into the domain of regulators, lawmakers and the general population in many parts of the world. For all parties involved in the dialog, establishing and maintaining a clear understanding of the essential concepts that are vital to achieving global equivalence among clinical laboratory measurements have therefore become a priority. Concepts that are critical to this discussion include standardization, traceability and harmonization. This report provides an updated discussion and practical definitions for these terms and others that are linked to metrological principles.

  17. Laboratory robotics -- An automated tool for preparing ion chromatography calibration standards

    SciTech Connect

    Chadwick, J.L.

    1995-04-01

    This paper describes the use of a laboratory robot as an automated tool for preparing multi-level calibration standards for On-Line Ion Chromatography (IC) Systems. The robot is designed for preparation of up to six levels of standards, with each level containing up to eleven ionic species in aqueous solution. The robot is required to add the standards` constituents as both a liquid and solid additions and to keep a record of exactly what goes into making up every standard. Utilizing a laboratory robot to prepare calibration standards provides significant benefits to the testing environment. These benefits include: accurate and precise calibration standards in individually capped containers with preparation traceability; automated and unattended multi-specie preparation for both anion and cation analytical channels; the ability to free up a test operator from a repetitive routine and re-apply those efforts to test operations; The robot uses a single channel IC to analyze each prepared standard for specie content and concentration. Those results are later used as a measure of quality control. System requirements and configurations, robotic operations, manpower requirements, analytical verification, accuracy and precision of prepared solutions, and robotic downtime are discussed in detail.

  18. [Implementation of the technical requirements of the UNE-EN-ISO 15189 quality standard in a mycobacterial laboratory].

    PubMed

    Guna Serrano, M del Remedio; Ocete Mochón, M Dolores; Lahiguera, M José; Bresó, M Carmen; Gimeno Cardona, Concepción

    2013-02-01

    The UNE-EN-ISO 15189:2007 standard defines the requirements for quality and competence that must be met by medical laboratories. These laboratories should use this international standard to develop their own quality management systems and to evaluate their own competencies; in turn, this standard will be used by accreditation bodies to confirm or recognize the laboratories' competence. In clinical microbiology laboratories, application of the standard implies the implementation of the technical and specific management requirements that must be met to achieve optimal quality when carrying out microbiological tests. In Spain, accreditation is granted by the Spanish Accreditation Body (Entidad Nacional de Acreditación). This review aims to discuss the practical application of the standard's technical requirements in mycobacterial laboratory. Firstly, we define the scope of accreditation. Secondly, we specify how the items of the standard on personnel management, control of equipment, environmental facilities, method validation, internal controls and customer satisfaction surveys were developed and implemented in our laboratory.

  19. Crack-Detection Experiments on Simulated Turbine Engine Disks in NASA Glenn Research Center's Rotordynamics Laboratory

    NASA Technical Reports Server (NTRS)

    Woike, Mark R.; Abdul-Aziz, Ali

    2010-01-01

    The development of new health-monitoring techniques requires the use of theoretical and experimental tools to allow new concepts to be demonstrated and validated prior to use on more complicated and expensive engine hardware. In order to meet this need, significant upgrades were made to NASA Glenn Research Center s Rotordynamics Laboratory and a series of tests were conducted on simulated turbine engine disks as a means of demonstrating potential crack-detection techniques. The Rotordynamics Laboratory consists of a high-precision spin rig that can rotate subscale engine disks at speeds up to 12,000 rpm. The crack-detection experiment involved introducing a notch on a subscale engine disk and measuring its vibration response using externally mounted blade-tip-clearance sensors as the disk was operated at speeds up to 12 000 rpm. Testing was accomplished on both a clean baseline disk and a disk with an artificial crack: a 50.8-mm- (2-in.-) long introduced notch. The disk s vibration responses were compared and evaluated against theoretical models to investigate how successful the technique was in detecting cracks. This paper presents the capabilities of the Rotordynamics Laboratory, the baseline theory and experimental setup for the crack-detection experiments, and the associated results from the latest test campaign.

  20. Organic Contamination Baseline Study in NASA Johnson Space Center Astromaterials Curation Laboratories

    NASA Technical Reports Server (NTRS)

    Calaway, Michael J.; Allen, Carlton C.; Allton, Judith H.

    2014-01-01

    Future robotic and human spaceflight missions to the Moon, Mars, asteroids, and comets will require curating astromaterial samples with minimal inorganic and organic contamination to preserve the scientific integrity of each sample. 21st century sample return missions will focus on strict protocols for reducing organic contamination that have not been seen since the Apollo manned lunar landing program. To properly curate these materials, the Astromaterials Acquisition and Curation Office under the Astromaterial Research and Exploration Science Directorate at NASA Johnson Space Center houses and protects all extraterrestrial materials brought back to Earth that are controlled by the United States government. During fiscal year 2012, we conducted a year-long project to compile historical documentation and laboratory tests involving organic investigations at these facilities. In addition, we developed a plan to determine the current state of organic cleanliness in curation laboratories housing astromaterials. This was accomplished by focusing on current procedures and protocols for cleaning, sample handling, and storage. While the intention of this report is to give a comprehensive overview of the current state of organic cleanliness in JSC curation laboratories, it also provides a baseline for determining whether our cleaning procedures and sample handling protocols need to be adapted and/or augmented to meet the new requirements for future human spaceflight and robotic sample return missions.

  1. The Center for Research on Evaluation, Standards, and Student Testing (CRESST). ERIC/TM Digest.

    ERIC Educational Resources Information Center

    Baker, Eva L.; Linn, Robert L.

    The Center for Research on Evaluation, Standards, and Student Testing (CRESST) attempts to advance the understanding of educational quality by research and development on the design, implementation, analysis, and use of assessment information. CRESST's research programs are directed at five major goals: (1) provide leadership to improve assessment…

  2. 78 FR 54655 - Center for Devices and Radiological Health: Draft Standard Operating Procedure for Level 1...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-05

    ... HUMAN SERVICES Food and Drug Administration Center for Devices and Radiological Health: Draft Standard Operating Procedure for Level 1, Immediately in Effect Guidance Documents on Premarket Data Issues; Availability and Request for Comments AGENCY: Food and Drug Administration, HHS. ACTION: Notice; request...

  3. Standards, Firewalls, and General Classroom Mayhem: Implementing Student-Centered Technology Projects in the Elementary Classroom

    ERIC Educational Resources Information Center

    Hofer, Mark; Swan, Kathleen Owings

    2006-01-01

    Educators are simultaneously bombarded with both calls to integrate technology in meaningful ways into their teaching and to promote more student-centered activities which combine both content learning and higher-order thinking. This is no small task given the range of student abilities and interests, the increasing emphasis on state standards and…

  4. An overview of the National Space Science data Center Standard Information Retrieval System (SIRS)

    NASA Technical Reports Server (NTRS)

    Shapiro, A.; Blecher, S.; Verson, E. E.; King, M. L. (Editor)

    1974-01-01

    A general overview is given of the National Space Science Data Center (NSSDC) Standard Information Retrieval System. A description, in general terms, the information system that contains the data files and the software system that processes and manipulates the files maintained at the Data Center. Emphasis is placed on providing users with an overview of the capabilities and uses of the NSSDC Standard Information Retrieval System (SIRS). Examples given are taken from the files at the Data Center. Detailed information about NSSDC data files is documented in a set of File Users Guides, with one user's guide prepared for each file processed by SIRS. Detailed information about SIRS is presented in the SIRS Users Guide.

  5. Groove depth measurements on roughness reference standards of the Croatian National Laboratory for Length (LFSB)

    NASA Astrophysics Data System (ADS)

    Baršić, Gorana; Mahović, Sanjin; Bartolo Picotto, Gian; Amer, Mohamed A.; Runje, Biserka

    2011-09-01

    In the Laboratory for Precise Measurements of Length, LFSB, which is now the Croatian National Laboratory for Length, unique roughness reference standards were developed in the year 1986. Because of the world-class quality of those standards and their measuring features, the same were sold in several European countries, and today they, among others, are used as roughness reference standards in Italy, Slovenia and Croatia. However, especially in the last decade, there was significant progress in the field of nanotechnology that led to the development of new measuring equipment. The above-mentioned standards due to their size, production technology and measuring features cannot fully meet metrological requirements in the field of nanometrology, i.e. they are not compatible with scanning probe microscopes. Therefore, it was decided to search for possible limitations in the procedure of groove depth measurements on the LFSB standards. In order to include as many measuring devices as possible, i.e. measurement methods, in this research, in 2008 the LFSB launched EURAMET Project 1012 'Limitations of methods for measuring the depth of the groove' in collaboration with national metrology institutes of Italy and Egypt. In this paper the results of measurements performed within the project are presented, and based on the obtained results, the advantages and limitations of the LFSB standards have been discussed, with recommendations for their improvement.

  6. Current practices and challenges in the standardization and harmonization of clinical laboratory tests.

    PubMed

    Vesper, Hubert W; Myers, Gary L; Miller, W Greg

    2016-09-01

    Effective patient care, clinical research, and public health efforts require comparability of laboratory results independent of time, place, and measurement procedure. Comparability is achieved by establishing metrological traceability, which ensures that measurement procedures measure the same quantity and that the calibration of measurement procedures is traceable to a common reference system consisting of reference methods and materials. Whereas standardization ensures traceability to the International System of Units, harmonization ensures traceability to a reference system agreed on by convention. This article provides an overview of standardization and harmonization with an emphasis on commutability as an important variable that affects testing accuracy. Commutability of reference materials is required to ensure that traceability is established appropriately and that laboratory results are comparable. The use of noncommutable reference materials leads to inaccurate results. Whereas procedures and protocols for standardizing measurements are established and have been successfully applied in efforts such as the Hormones Standardization Program of the CDC, harmonization activities require new, more complex procedures and approaches. The American Association for Clinical Chemistry, together with its domestic and international partners, formed the International Consortium for Harmonization of Clinical Laboratory Results to coordinate harmonization efforts. Reference systems, as well as procedures and protocols to establish traceability of clinical laboratory tests, have been established and continue to be developed by national and international groups and organizations. Serum tests of thyroid function, including those for the thyroid hormones thyroxine and triiodothyronine, are among the clinical procedures for which standardization efforts are well under way. Approaches to the harmonization of measurement procedures for serum concentrations of thyroid

  7. Advances in Engine Test Capabilities at the NASA Glenn Research Center's Propulsion Systems Laboratory

    NASA Technical Reports Server (NTRS)

    Pachlhofer, Peter M.; Panek, Joseph W.; Dicki, Dennis J.; Piendl, Barry R.; Lizanich, Paul J.; Klann, Gary A.

    2006-01-01

    The Propulsion Systems Laboratory at the National Aeronautics and Space Administration (NASA) Glenn Research Center is one of the premier U.S. facilities for research on advanced aeropropulsion systems. The facility can simulate a wide range of altitude and Mach number conditions while supplying the aeropropulsion system with all the support services necessary to operate at those conditions. Test data are recorded on a combination of steady-state and highspeed data-acquisition systems. Recently a number of upgrades were made to the facility to meet demanding new requirements for the latest aeropropulsion concepts and to improve operational efficiency. Improvements were made to data-acquisition systems, facility and engine-control systems, test-condition simulation systems, video capture and display capabilities, and personnel training procedures. This paper discusses the facility s capabilities, recent upgrades, and planned future improvements.

  8. Ice Crystal Icing Engine Testing in the NASA Glenn Research Center's Propulsion Systems Laboratory: Altitude Investigation

    NASA Technical Reports Server (NTRS)

    Oliver, Michael J.

    2014-01-01

    The National Aeronautics and Space Administration (NASA) conducted a full scale ice crystal icing turbofan engine test using an obsolete Allied Signal ALF502-R5 engine in the Propulsion Systems Laboratory (PSL) at NASA Glenn Research Center. The test article used was the exact engine that experienced a loss of power event after the ingestion of ice crystals while operating at high altitude during a 1997 Honeywell flight test campaign investigating the turbofan engine ice crystal icing phenomena. The test plan included test points conducted at the known flight test campaign field event pressure altitude and at various pressure altitudes ranging from low to high throughout the engine operating envelope. The test article experienced a loss of power event at each of the altitudes tested. For each pressure altitude test point conducted the ambient static temperature was predicted using a NASA engine icing risk computer model for the given ambient static pressure while maintaining the engine speed.

  9. Food intake in laboratory rats provided standard and fenbendazole-supplemented diets.

    PubMed

    Vento, Peter J; Swartz, Megan E; Martin, Lisa Be; Daniels, Derek

    2008-11-01

    The benzimidazole anthelmintic fenbendazole (FBZ) is a common and effective treatment for pinworm infestation in laboratory animal colonies. Although many investigators have examined the potential for deleterious biologic effects of FBZ, more subtle aspects of the treatment remain untested. Accordingly, we evaluated differences in food intake when healthy male Sprague-Dawley rats were provided a standard nonmedicated laboratory rodent chow or the same chow supplemented with FBZ. We also tested for a preference for either food type when subjects were provided a choice of the 2 diets. Data from these experiments showed no differences in food intake or body weight when rats were maintained on either standard or FBZ-supplemented chow. When the rats were given access to both the standard and FBZ-supplemented diets, they showed a clear preference for the standard diet. The preference for the standard diet indicates that the rats can discriminate between the 2 foods and may avoid the FBZ-supplemented chow when possible. Investigators conducting experiments during treatment with FBZ in which differences in food preference are relevant should be aware of these data and plan their studies accordingly.

  10. Termite-Susceptible Species of Wood for Inclusion as a Reference in Indonesian Standardized Laboratory Testing.

    PubMed

    Arinana; Tsunoda, Kunio; Herliyana, Elis N; Hadi, Yusuf S

    2012-03-28

    Standardized laboratory testing of wood and wood-based products against subterranean termites in Indonesia (SNI 01.7207-2006) (SNI) has no requirement for the inclusion of a comparative reference species of wood (reference control). This is considered a weakness of the Indonesian standard. Consequently, a study was undertaken to identify a suitable Indonesian species of community wood that could be used as a reference control. Four candidate species of community woods: Acacia mangium, Hevea brasiliensis, Paraserianthes falcataria and Pinus merkusii were selected for testing their susceptibility to feeding by Coptotermes formosanus. Two testing methods (SNI and the Japanese standard method JIS K 1571-2004) were used to compare the susceptibility of each species of wood. Included in the study was Cryptomeria japonica, the reference control specified in the Japanese standard. The results of the study indicated that P. merkusii is a suitable reference species of wood for inclusion in laboratory tests against subterranean termites, conducted in accordance with the Indonesian standard (SNI 01.7207-2006).

  11. An Australian secondary standard dosimetry laboratory participation in IAEA postal dose audits.

    PubMed

    Davies, J B; Izewska, J; Meriaty, H; Baldock, C

    2013-03-01

    For over 30 years, the International Atomic Energy Agency (IAEA) and the World Health Organization (WHO) have jointly monitored activities of secondary standard dosimetry laboratories (SSDLs) through postal dose audits with the aim of achieving consistency in dosimetry throughout the world. The Australian Nuclear Science and Technology Organisation (ANSTO) maintains an SSDL and is a member of the IAEA/WHO SSDL Network. Postal dose audit results at this Australian SSDL from 2001 to 2011 demonstrate the consistency of absorbed dose to water measurements, underpinned by the primary standard maintained at the Australian Radiation Protection and Nuclear Safety Agency (ARPANSA).

  12. Description of the Structural Materials Information Center being established at the Oak Ridge National Laboratory

    SciTech Connect

    Oland, B.

    1990-01-01

    The US Nuclear Regulatory Commission has initiated a Structural aging Program at the Oak Ridge National Laboratory to identify potential structural safety issues related to continued service of nuclear power plants and to establish criteria for evaluating and resolving these issues. One of the tasks in this program focuses on the establishment of a Structural Materials Information Center where data and information on the time variation of concrete and concrete-related material properties under the influence of pertinent environmental stressors and aging factors will be collected and assembled into a database. This database will be used to assist in the prediction of potential long-term deterioration of critical structural components in nuclear power plants and to establish limits on hostile environmental exposure for these structures and materials. Materials property data and information will be collected at the Structural Materials Information Center from open literature, published references, and identifiable sources. Initially, the database will include portland cement concrete, metallic reinforcement, prestressing tendon and structural steel materials. Then, as data and information for other material systems are obtained, the database will be expanded and updated. The database will be developed and presented in two complementary formats. The Structural Materials Handbook will be published in four volumes as an expandable, hard copy handbook. The Materials Electronic Database will be developed to reflect the same information as contained in the handbook, but will be formatted for use on an IBM or IBM-compatible personal computer.

  13. Towards the development of a fossil bone geochemical standard: an inter-laboratory study.

    PubMed

    Chavagnac, V; Milton, J A; Green, D R H; Breuer, J; Bruguier, O; Jacob, D E; Jong, T; Kamenov, G D; Le Huray, J; Liu, Y; Palmer, M R; Pourtalès, S; Roduhskin, I; Soldati, A; Trueman, C N; Yuan, H

    2007-09-19

    Ten international laboratories participated in an inter-laboratory comparison of a fossil bone composite with the objective of producing a matrix and structure-matched reference material for studies of the bio-mineralization of ancient fossil bone. We report the major and trace element compositions of the fossil bone composite, using in-situ method as well as various wet chemical digestion techniques. For major element concentrations, the intra-laboratory analytical precision (%RSD(r)) ranges from 7 to 18%, with higher percentages for Ti and K. The %RSD(r) are smaller than the inter-laboratory analytical precision (%RSD(R); <15-30%). Trace element concentrations vary by approximately 5 orders of magnitude (0.1 mg kg(-1) for Th to 10,000 mg kg(-1) for Ba). The intra-laboratory analytical precision %RSD(r) varies between 8 and 45%. The reproducibility values (%RSD(R)) range from 13 to <50%, although extreme value >100% was found for the high field strength elements (Hf, Th, Zr, Nb). The rare earth element (REE) concentrations, which vary over 3 orders of magnitude, have %RSD(r) and %RSD(R) values at 8-15% and 20-32%, respectively. However, the REE patterns (which are very important for paleo-environmental, taphonomic and paleo-oceanographic analyses) are much more consistent. These data suggest that the complex and unpredictable nature of the mineralogical and chemical composition of fossil bone makes it difficult to set-up and calibrate analytical instruments using conventional standards, and may result in non-spectral matrix effects. We propose an analytical protocol that can be employed in future inter-laboratory studies to produce a certified fossil bone geochemical standard.

  14. Microfluidic cartridges for DNA purification and genotyping processed in standard laboratory instruments

    NASA Astrophysics Data System (ADS)

    Focke, Maximilian; Mark, Daniel; Stumpf, Fabian; Müller, Martina; Roth, Günter; Zengerle, Roland; von Stetten, Felix

    2011-06-01

    Two microfluidic cartridges intended for upgrading standard laboratory instruments with automated liquid handling capability by use of centrifugal forces are presented. The first microfluidic cartridge enables purification of DNA from human whole blood and is operated in a standard laboratory centrifuge. The second microfluidic catridge enables genotyping of pathogens by geometrically multiplexed real-time PCR. It is operated in a slightly modified off-the-shelf thermal cycler. Both solutions aim at smart and cost-efficient ways to automate work flows in laboratories. The DNA purification cartridge automates all liquid handling steps starting from a lysed blood sample to PCR ready DNA. The cartridge contains two manually crushable glass ampoules with liquid reagents. The DNA yield extracted from a 32 μl blood sample is 192 +/- 30 ng which corresponds to 53 +/- 8% of a reference extraction. The genotyping cartridge is applied to analyse isolates of the multi-resistant Staphyloccus aureus (MRSA) by real-time PCR. The wells contain pre-stored dry reagents such as primers and probes. Evaluation of the system with 44 genotyping assays showed a 100% specificity and agreement with the reference assays in standard tubes. The lower limit of detection was well below 10 copies of DNA per reaction.

  15. [Policies and standards applied to municipal day care centers in Rio de Janeiro].

    PubMed

    de Vasconcelos, Rafaela Moledo; Tancredi, Rinaldini Coralini Philippo; Marin, Victor Augustus

    2013-11-01

    Day care centers were first established in Brazil with the aim of reducing infant mortality rates, however the incidence of foodborne disease transmission has been on the increase. The World Health Organization (WHO) estimates that each year 1.8 million deaths worldwide occur in children under 5 years of age, which is attributed to the consumption of contaminated food. However, Brazilian legislation does not provide specific rules of operation for day care center kitchens. Thus, the scope of this study is to research the standards relating to the operation of day care centers, discussing the health regulations related to food production. By means of a review of electronic pages of various government organs, the regulations inherent to the operation and production of food in day care centers were examined. After scrutiny of the twenty-seven pieces of legislation found, there is a concern with water quality, supply of food, the control of pests and vectors, structural conditions and food policies. In spite of this, it was seen that not all the surveillance policies for the quality of food offered in day care centers are effective. Also observed was the lack of a specific regulation that establishes the quality criteria for safe handling of food in day care centers.

  16. 40 CFR 262.206 - Labeling and management standards for containers of unwanted material in the laboratory.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Material for Laboratories Owned by Eligible Academic Entities § 262.206 Labeling and management standards for containers of unwanted material in the laboratory. An eligible academic entity must manage... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Labeling and management standards...

  17. 75 FR 5088 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-01

    ... HUMAN SERVICES Substance Abuse and Mental Health Services Administration Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for Federal Agencies AGENCY: Substance... Standards Council of Canada (SCC) voted to end its Laboratory Accreditation Program for Substance...

  18. Applying IEEE storage system management standards at the National Storage Laboratory

    SciTech Connect

    Louis, S.; Hyer, S.W.

    1992-12-04

    Since its inception in 1990, the IEEE Storage System Standards Working Group has identified storage-system management as an area in need of further development The pressing need for standards in storage-system management arises from the requirement to exchange management information and to provide control in a consistent predictable manner between the components of a storage system. An appropriate set of management standards will allow multiple vendors to supply storage management subsystems or applications that are integral to or compatible with new storage systems conforming to future IEEE standards. An early, practical application of IEEE storage-system-management work is being pursued at the National Storage Laboratory (NSL), a recently-formed industrial collaboration at Lawrence Livermore National Laboratory. The NSL`s purpose is to develop advanced hardware and software technologies for high-performance, distributed storage systems. Since storage system management is of critical concern, it is being explored in depth at the NSL. Work was initiated to define basic management requirements and develop generalized graphical-user-interface tools using remote-procedure-call mechanisms to implement the NSL`s conceptual management framework. Several constraints were imposed on the development of early versions of this work to maintain compatibility with the NSL`s underlying UniTree-based software architecture and to provide timely prototypes and proof of concept. The project leverages the on-going standards work of the IEEE Storage System Standards Working Group (SSSWG) and also explores some of the relationships and interactions between IEEE storage-system management and more well known management methods for distributed systems and networks. It will have long term benefits by providing ``real-life`` storage-system-management requirements to the IEEE SSSWG for validation of evolving standards.

  19. Accuracy of the Clinical Diagnosis of Vaginitis Compared to a DNA Probe Laboratory Standard

    PubMed Central

    Lowe, Nancy K.; Neal, Jeremy L.; Ryan-Wenger, Nancy A.

    2009-01-01

    Objective To estimate the accuracy of the clinical diagnosis of the three most common causes of acute vulvovaginal symptoms (bacterial vaginosis, candidiasis vaginitis, and trichomoniasis vaginalis) using a traditional, standardized clinical diagnostic protocol compared to a DNA probe laboratory standard. Methods This prospective clinical comparative study had a sample of 535 active duty United States military women presenting with vulovaginal symptoms. Clinical diagnoses were made by research staff using a standardized protocol of history, physical examination including pelvic examination, determination of vaginal pH, vaginal fluid amines test, and wet-prep microscopy. Vaginal fluid samples were obtained for DNA analysis. The research clinicians were blinded to the DNA results. Results The participants described a presenting symptom of abnormal discharge (50%), itching/irritation (33%), malodor (10%), burning (4%), or others such as vulvar pain and vaginal discomfort. According to laboratory standard, there were 225 cases (42%) of bacterial vaginosis 76 cases (14%) of candidiasis vaginitis, 8 cases (1.5%) of trichomoniasis vaginalis, 87 cases of mixed infections (16%), and 139 negative cases (26%). For each single infection, the clinical diagnosis had a sensitivity and specificity of 80.8% and 70.0% for bacterial vaginosis; 83.8% and 84.8% for candidiasis vaginitis; and 84.6% and 99.6% for trichomoniasis vaginalis when compared to the DNA probe standard. Conclusion Compared to a DNA probe standard, clinical diagnosis is 81-85% sensitive and 70- 99% specific for bacterial vaginosis, candida vaginitis, and trichomoniasis. Even under research conditions that provided clinicians with sufficient time and materials to conduct a thorough and standardized clinical evaluation, the diagnosis and therefore, subsequent treatment of these common vaginal problems remains difficult. PMID:19104364

  20. Uranium Enrichment Standards of the Y-12 Nuclear Detection and Sensor Testing Center

    SciTech Connect

    Cantrell, J.

    2012-05-23

    The Y-12 National Security Complex has recently fabricated and characterized a new series of metallic uranium standards for use in the Nuclear Detection and Sensor Testing Center (NDSTC). Ten uranium metal disks with enrichments varying from 0.2 to 93.2% {sup 235}U were designed to provide researchers access to a wide variety of measurement scenarios in a single testing venue. Special care was taken in the selection of the enrichments in order to closely bracket the definitions of reactor fuel at 4% {sup 235}U and that of highly enriched uranium (HEU) at 20% {sup 235}U. Each standard is well characterized using analytical chemistry as well as a series of gamma-ray spectrometry measurements. Gamma-ray spectra of these standards are being archived in a reference library for use by customers of the NDSTC. A software database tool has been created that allows for easier access and comparison of various spectra. Information provided through the database includes: raw count data (including background spectra), regions of interest (ROIs), and full width half maximum calculations. Input is being sought from the user community on future needs including enhancements to the spectral database and additional Uranium standards, shielding configurations and detector types. A related presentation are planned for the INMM 53rd Annual Meeting (Hull, et al.), which describe new uranium chemical compound standards and testing opportunities at Y-12 Nuclear Detection and Sensor Testing Center (NDSTC).

  1. Changing resident test ordering behavior: a multilevel intervention to decrease laboratory utilization at an academic medical center.

    PubMed

    Vidyarthi, Arpana R; Hamill, Timothy; Green, Adrienne L; Rosenbluth, Glenn; Baron, Robert B

    2015-01-01

    Hospital laboratory test volume is increasing, and overutilization contributes to errors and costs. Efforts to reduce laboratory utilization have targeted aspects of ordering behavior, but few have utilized a multilevel collaborative approach. The study team partnered with residents to reduce unnecessary laboratory tests and associated costs through multilevel interventions across the academic medical center. The study team selected laboratory tests for intervention based on cost, volume, and ordering frequency (complete blood count [CBC] and CBC with differential, common electrolytes, blood enzymes, and liver function tests). Interventions were designed collaboratively with residents and targeted components of ordering behavior, including system changes, teaching, social marketing, academic detailing, financial incentives, and audit/feedback. Laboratory ordering was reduced by 8% cumulatively over 3 years, saving $2 019 000. By involving residents at every stage of the intervention and targeting multiple levels simultaneously, laboratory utilization was reduced and cost savings were sustained over 3 years.

  2. Laboratory security and emergency response guidance for laboratories working with select agents. Centers for Disease Control and Prevention.

    PubMed

    Richmond, Jonathan Y; Nesby-O'Dell, Shanna L

    2002-12-06

    In recent years, concern has increased regarding use of biologic materials as agents of terrorism, but these same agents are often necessary tools in clinical and research microbiology laboratories. Traditional biosafety guidelines for laboratories have emphasized use of optimal work practices, appropriate containment equipment, well-designed facilities, and administrative controls to minimize risk of worker injury and to ensure safeguards against laboratory contamination. The guidelines discussed in this report were first published in 1999 (U.S. Department of Health and Human Services/CDC and National Institutes of Health. Biosafety in microbiological and biomedical laboratories [BMBL]. Richmond JY, McKinney RW, eds. 4th ed. Washington, DC: US Department of Health and Human Services, 1999 [Appendix F]). In that report, physical security concerns were addressed, and efforts were focused on preventing unauthorized entry to laboratory areas and preventing unauthorized removal of dangerous biologic agents from the laboratory. Appendix F of BMBL is now being revised to include additional information regarding personnel risk assessments, and inventory controls. The guidelines contained in this report are intended for laboratories working with select agents under biosafety-level 2, 3, or 4 conditions as described in Sections II and III of BMBL. These recommendations include conducting facility risk assessments and developing comprehensive security plans to minimize the probability of misuse of select agents. Risk assessments should include systematic, site-specific reviews of 1) physical security; 2) security of data and electronic technology systems; 3) employee security; 4) access controls to laboratory and animal areas; 5) procedures for agent inventory and accountability; 6) shipping/transfer and receiving of select agents; 7) unintentional incident and injury policies; 8) emergency response plans; and 9) policies that address breaches in security. The security plan

  3. Biomedical communications centers--a profile/evaluation instrument study of underlying standards.

    PubMed

    Glickman, J T; Eicholzer, W A

    1987-01-01

    The "ABCD Profile/Evaluation Instrument" offers directors of individual biomedical communications centers a way to measure their own progress towards meeting standards of excellence. It provides guidelines for review of biomedical communications centers in a model similar to the clinical and basic medical science departments' review. Based on the results of this study, many of the directors seemed to be looking for more formal structure of biomedical communications centers involvement. Use of the Profile/Evaluation Instrument helps address this need and allows discussion in areas such as the department's existence and function in relation to its host institution. In March of 1985, the ABCD used the Profile/Evaluation Instrument standards as parameters of responsibility and service provided by biomedical communications units in its analysis and response to the AAMC GPEP report (Allan and Bradford 1985). The instrument also triggers discussion of new areas of review needed within departments. The process of matching biomedical communications job requirements and assessment training criteria will be explored in the future expansion of the personnel section of the instrument. These and other areas are crucial to the survival and well-being of biomedical communications centers. The "ABCD Profile/Evaluation Instrument" establishes a concrete reference for external review by outside agencies and internal review by administration or the department directors themselves. It offers a continuing body of information that provides the basis for future planning in the field of biomedical communications.

  4. Russian Tu-144LL SST Flying Laboratory Landing with Drag Chutes at Zhukovsky Air Development Center

    NASA Technical Reports Server (NTRS)

    1997-01-01

    The modified Tupolev Tu-144 supersonic flying laboratory touches down and deploys a trio of drag chutes following a test flight at the Zhukovsky Air Development Center near Moscow, Russia, in July 1997. NASA teamed with American and Russian aerospace industries for an extended period in a joint international research program featuring the Russian-built Tu-144LL supersonic aircraft. The object of the program was to develop technologies for a proposed future second-generation supersonic airliner to be developed in the 21st Century. The aircraft's initial flight phase began in June 1996 and concluded in February 1998 after 19 research flights. A shorter follow-on program involving seven flights began in September 1998 and concluded in April 1999. All flights were conducted in Russia from Tupolev's facility at the Zhukovsky Air Development Center near Moscow. The centerpiece of the research program was the Tu 144LL, a first-generation Russian supersonic jetliner that was modified by its developer/builder, Tupolev ANTK (aviatsionnyy nauchno-tekhnicheskiy kompleks-roughly, aviation technical complex), into a flying laboratory for supersonic research. Using the Tu-144LL to conduct flight research experiments, researchers compared full-scale supersonic aircraft flight data with results from models in wind tunnels, computer-aided techniques, and other flight tests. The experiments provided unique aerodynamic, structures, acoustics, and operating environment data on supersonic passenger aircraft. Data collected from the research program was being used to develop the technology base for a proposed future American-built supersonic jetliner. Although actual development of such an advanced supersonic transport (SST) is currently on hold, commercial aviation experts estimate that a market for up to 500 such aircraft could develop by the third decade of the 21st Century. The Tu-144LL used in the NASA-sponsored research program was a 'D' model with different engines than were used

  5. Russian Tu-144LL SST Flying Laboratory Takeoff at Zhukovsky Air Development Center

    NASA Technical Reports Server (NTRS)

    1997-01-01

    With its nose drooped and canards extended, the Tupolev Tu-144LL supersonic flying laboratory lifts off from the Zhukovsky Air Development Center near Moscow, Russia on a 1997 test flight. NASA teamed with American and Russian aerospace industries for an extended period in a joint international research program featuring the Russian-built Tu-144LL supersonic aircraft. The object of the program was to develop technologies for a proposed future second-generation supersonic airliner to be developed in the 21st Century. The aircraft's initial flight phase began in June 1996 and concluded in February 1998 after 19 research flights. A shorter follow-on program involving seven flights began in September 1998 and concluded in April 1999. All flights were conducted in Russia from Tupolev's facility at the Zhukovsky Air Development Center near Moscow. The centerpiece of the research program was the Tu 144LL, a first-generation Russian supersonic jetliner that was modified by its developer/builder, Tupolev ANTK (aviatsionnyy nauchno-tekhnicheskiy kompleks-roughly, aviation technical complex), into a flying laboratory for supersonic research. Using the Tu-144LL to conduct flight research experiments, researchers compared full-scale supersonic aircraft flight data with results from models in wind tunnels, computer-aided techniques, and other flight tests. The experiments provided unique aerodynamic, structures, acoustics, and operating environment data on supersonic passenger aircraft. Data collected from the research program was being used to develop the technology base for a proposed future American-built supersonic jetliner. Although actual development of such an advanced supersonic transport (SST) is currently on hold, commercial aviation experts estimate that a market for up to 500 such aircraft could develop by the third decade of the 21st Century. The Tu-144LL used in the NASA-sponsored research program was a 'D' model with different engines than were used in production

  6. Russian Tu-144LL SST Flying Laboratory Landing at Zhukovsky Air Development Center

    NASA Technical Reports Server (NTRS)

    1997-01-01

    The Tupolev Tu-144LL supersonic flying laboratory touches down at the Zhukovsky Air Development Center near Moscow, Russia, following a 1997 test flight. NASA teamed with American and Russian aerospace industries for an extended period in a joint international research program featuring the Russian-built Tu-144LL supersonic aircraft. The object of the program was to develop technologies for a proposed future second-generation supersonic airliner to be developed in the 21st Century. The aircraft's initial flight phase began in June 1996 and concluded in February 1998 after 19 research flights. A shorter follow-on program involving seven flights began in September 1998 and concluded in April 1999. All flights were conducted in Russia from Tupolev's facility at the Zhukovsky Air Development Center near Moscow. The centerpiece of the research program was the Tu 144LL, a first-generation Russian supersonic jetliner that was modified by its developer/builder, Tupolev ANTK (aviatsionnyy nauchno-tekhnicheskiy kompleks-roughly, aviation technical complex), into a flying laboratory for supersonic research. Using the Tu-144LL to conduct flight research experiments, researchers compared full-scale supersonic aircraft flight data with results from models in wind tunnels, computer-aided techniques, and other flight tests. The experiments provided unique aerodynamic, structures, acoustics, and operating environment data on supersonic passenger aircraft. Data collected from the research program was being used to develop the technology base for a proposed future American-built supersonic jetliner. Although actual development of such an advanced supersonic transport (SST) is currently on hold, commercial aviation experts estimate that a market for up to 500 such aircraft could develop by the third decade of the 21st Century. The Tu-144LL used in the NASA-sponsored research program was a 'D' model with different engines than were used in production-model aircraft. Fifty experiments

  7. Russian Tu-144LL SST Flying Laboratory Landing at Zhukovsky Air Development Center

    NASA Technical Reports Server (NTRS)

    1997-01-01

    The Tupolev Tu-144LL supersonic flying laboratory lifts off from the Zhukovsky Air Development Center near Moscow, Russia, on a 1997 test flight. NASA teamed with American and Russian aerospace industries for an extended period in a joint international research program featuring the Russian-built Tu-144LL supersonic aircraft. The object of the program was to develop technologies for a proposed future second-generation supersonic airliner to be developed in the 21st Century. The aircraft's initial flight phase began in June 1996 and concluded in February 1998 after 19 research flights. A shorter follow-on program involving seven flights began in September 1998 and concluded in April 1999. All flights were conducted in Russia from Tupolev's facility at the Zhukovsky Air Development Center near Moscow. The centerpiece of the research program was the Tu 144LL, a first-generation Russian supersonic jetliner that was modified by its developer/builder, Tupolev ANTK (aviatsionnyy nauchno-tekhnicheskiy kompleks-roughly, aviation technical complex), into a flying laboratory for supersonic research. Using the Tu-144LL to conduct flight research experiments, researchers compared full-scale supersonic aircraft flight data with results from models in wind tunnels, computer-aided techniques, and other flight tests. The experiments provided unique aerodynamic, structures, acoustics, and operating environment data on supersonic passenger aircraft. Data collected from the research program was being used to develop the technology base for a proposed future American-built supersonic jetliner. Although actual development of such an advanced supersonic transport (SST) is currently on hold, commercial aviation experts estimate that a market for up to 500 such aircraft could develop by the third decade of the 21st Century. The Tu-144LL used in the NASA-sponsored research program was a 'D' model with different engines than were used in production-model aircraft. Fifty experiments were

  8. [Law, guidelines and standards relevant to laboratory animals and animal experimentation].

    PubMed

    Takagaki, Y

    1982-04-01

    Presently available laws guidelines and standards relevant to laboratory animals and animal experimentation are reviewed. In Japan there exist Animal Protection and Management Act, and the Guideline for Animal Care and Management which was later prepared in accordance with the former act. These are comparable in quality to those seen in foreign countries such as the Cruelty to Animals Act of Great Britain or the Animal Welfare Act of U.S.A. As for laboratory animals, however, only basic matters appear there, and that is why the Japanese National Academy of Science in 1980 proposed legislation of a guideline for animal experimentation to the government. It is awaited to legislate sooner the one comparable to the Guidelines for the Regulation of Animal Experimentation prepared by ICLA in 1974. Other laws and regulations referred and discussed here are: *standards and guidelines for breeding, care and management of laboratory animals *veterinary laws and regulations which should be referred when domestic or wild animals are to be used for experiments *laws and regulations for general housing construction and environmental protection *regulations for particular experiments where radioisotopes, microbial infections or recombinant DNA are in use

  9. Towards the Standardization of a MATLAB-Based Control Systems Laboratory Experience for Undergraduate Students

    SciTech Connect

    Dixon, W.E.

    2001-03-15

    This paper seeks to begin a discussion with regard to developing standardized Computer Aided Control System Design (CACSD) tools that are typically utilized in an undergraduate controls laboratory. The advocated CACSD design tools are based on the popular, commercially available MATLAB environment, the Simulink toolbox, and the Real-Time Workshop toolbox. The primary advantages of the proposed approach are as follows: (1) the required computer hardware is low cost, (2) commercially available plants from different manufacturers can be supported under the same CACSD environment with no hardware modifications, (3) both the Windows and Linux operating systems can be supported via the MATLAB based Real-Time Windows Target and the Quality Real Time Systems (QRTS) based Real-Time Linux Target, and (4) the Simulink block diagram approach can be utilized to prototype control strategies; thereby, eliminating the need for low level programming skills. It is believed that the above advantages related to standardization of the CACSD design tools will facilitate: (1) the sharing of laboratory resources within each university (i.e., between departments) and (2) the development of Internet laboratory experiences for students (i.e., between universities).

  10. NASA's Corrosion Technology Laboratory at the Kennedy Space Center: Anticipating, Managing, and Preventing Corrosion

    NASA Technical Reports Server (NTRS)

    Calle, Luz Marina

    2014-01-01

    Corrosion is the degradation of a material that results from its interaction with the environment. The marine environment at NASAs Kennedy Space Center (KSC) has been documented by ASM International (formerly American Society for Metals) as the most corrosive in the United States. With the introduction of the Space Shuttle in 1981, the already highly corrosive conditions at the launch pads were rendered even more severe by the 70 tons of highly corrosive hydrochloric acid that were generated by the solid rocket boosters. Numerous failures at the launch pads are caused by corrosion.The structural integrity of ground infrastructure and flight hardware is critical to the success, safety, cost, and sustainability of space missions. As a result of fifty years of experience with launch and ground operations in a natural marine environment that is highly corrosive, NASAs Corrosion Technology Laboratory at KSC is a major source of corrosion control expertise in the launch and other environments. Throughout its history, the Laboratory has evolved from what started as an atmospheric exposure facility near NASAs launch pads into a world-wide recognized capability that provides technical innovations and engineering services in all areas of corrosion for NASA and external customers.This presentation will provide a historical overview of the role of NASAs Corrosion Technology in anticipating, managing, and preventing corrosion. One important challenge in managing and preventing corrosion involves the detrimental impact on humans and the environment of what have been very effective corrosion control strategies. This challenge has motivated the development of new corrosion control technologies that are more effective and environmentally friendly. Strategies for improved corrosion protection and durability can have a huge impact on the economic sustainability of human spaceflight operations.

  11. An exploration of certain factors and skills impacting effective laboratory-centered, inquiry-focused science instruction

    NASA Astrophysics Data System (ADS)

    Lombardo, Anthony S.

    The research reported herein addressed the need to examine the impact of certain factors and skills that science teachers' professional judgments indicate as significant in being able to carry out inquiry focused laboratory centered instruction in grades 7--12. Four groups of practicing science teachers participated in the study. Group A included 16 urban science teachers who had previously completed long term professional development in the laboratory-centered, inquiry-focused approach to science instruction. Group B included 24 urban science teachers who had not received long term professional development. Group C included 13 science teachers from suburban school districts, most of whom received no long term professional development in the laboratory-centered, inquiry-focused approach to science instruction. Group D was derived from groups A, B, and C and were identified, following criteria, to have a clear understanding of the inquiry focused approach to science instruction as described by the Levels of Inquiry Matrix. A survey instrument, developed to obtain the professional judgments of teachers, was designed so that the results could be analyzed using nonparametric statistics. The survey requested that the teachers rate 19 factors that had an impact on their ability to carry out laboratory-centered, inquiry-focused instruction. The survey also collected data about the environments in which these teachers carry out instruction as well as the skills that the teachers believe should be developed by students from involvement in this approach to science instruction. Results indicate that science teachers from all four study groups agreed that access to laboratory facilities, safety equipment, and laboratory instruments are most important to be able to effectively carry out instruction that is laboratory centered and inquiry focused. Other factors ranked behind these but also highly rated were teacher training, administrative support, laboratory supplies, and

  12. Lawrence Livermore National Laboratory Site Specific Standard for Nonnuclear Safety Analysis

    SciTech Connect

    Failor, R; Beach, D R; Brereton, S; Hildum, J S; Ingram, C; Spagnolo, S; Van Warmerdam, C

    2003-05-06

    Lawrence Livermore National Laboratory (LLNL) and the NNSA Livermore Site Office teamed up to prepare a site specific work smart standard setting requirements for preparation of safety basis documents for LLNL non-nuclear operations and facilities. This standard documents how all hazards (biological, chemical, explosive, industrial, and radiological) shall be evaluated, classified, analyzed, and controls developed. This standard was developed to evaluate hazards at the facility level to mesh with LLNL's ISM system for reviewing hazards at the activity level. This standard presents an approach to establishing safety basis for non-nuclear operations and activities, taking a graded approach based on the potential for impacts to the health of collocated workers and the public. Direct worker safety is covered by LLNL's work activity level reviews and requirements. This standard includes streamlined mechanisms for classifying hazards based upon the unmitigated potential for human health impacts. A review or practices at several private industries, government laboratories, and DOE complex sites provided a benchmark and comparison of safety analysis processes. These approaches were compared with LLNL's existing systems, leading to a determination that facility specific safety basis documents added value to a rapid authorization for new work activities in LLNL facilities. A process for hazard classification that would be viewed as more credible than the previous facility classification system was developed, including a method allowing correlation of chemical inventories with TEEL* concentrations. A graded approach for classification of explosive hazards, consistent with the DOE Explosive Safety Manual, was included. The standard was designed to be complementary with LLNL's existing work smart standards covering the hazards identified in a facility. A standard for LLNL's Work Smart Standard set was prepared that will assure all hazards are covered with appropriate levels of

  13. 75 FR 62842 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-13

    ..., 11401 I-30, Little Rock, AR 72209-7056, 501-202-2783, (Formerly: Forensic Toxicology Laboratory Baptist... Affairs Medical Center, Forensic Toxicology Laboratory, 1 Veterans Drive, Minneapolis, MN 55417, 612-725...-747-3774, (Formerly: University of Texas Medical Branch, Clinical Chemistry Division; UTMB...

  14. 75 FR 154 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-04

    ..., Exit 7, Little Rock, AR 72205-7299, 501-202-2783 (Formerly: Forensic Toxicology Laboratory Baptist... Affairs Medical Center, Forensic Toxicology Laboratory, 1 Veterans Drive, Minneapolis, MN 55417, 612-725...-747-3774 (Formerly: University of Texas Medical Branch, Clinical Chemistry Division; UTMB...

  15. 75 FR 45128 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-02

    ... Laboratory, 9601 I-630, Exit 7, Little Rock, AR 72205-7299, 501-202-2783, (Formerly: Forensic Toxicology... Affairs Medical Center, Forensic Toxicology Laboratory, 1 Veterans Drive, Minneapolis, MN 55417, 612-725...-3774, (Formerly: University of Texas Medical Branch, Clinical Chemistry Division; UTMB...

  16. 75 FR 39023 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-07

    ...--Toxicology Laboratory, 9601 I-630, Exit 7, Little Rock, AR 72205-7299, 501-202-2783. (Formerly: Forensic...-5295. Minneapolis Veterans Affairs Medical Center, Forensic Toxicology Laboratory, 1 Veterans Drive..., Pasadena, TX 77504, 888-747-3774. (Formerly: University of Texas Medical Branch, Clinical...

  17. 75 FR 32950 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-10

    ...-Toxicology Laboratory, 9601 I-630, Exit 7, Little Rock, AR 72205-7299. 501-202-2783. (Formerly: Forensic...-5295. Minneapolis Veterans Affairs Medical Center, Forensic Toxicology Laboratory, 1 Veterans Drive..., Pasadena, TX 77504. 888-747-3774. (Formerly: University of Texas Medical Branch, Clinical...

  18. 75 FR 27348 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-14

    ... Laboratory, 9601 I-630, Exit 7, Little Rock, AR 72205-7299, 501-202-2783. (Formerly: Forensic Toxicology...-5295. Minneapolis Veterans Affairs Medical Center, Forensic Toxicology Laboratory, 1 Veterans Drive..., Pasadena, TX 77504, 888-747-3774. (Formerly: University of Texas Medical Branch, Clinical...

  19. 75 FR 55795 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-14

    ...-Toxicology Laboratory, 11401 I-30, Little Rock, AR 72209-7056, 501-202-2783 (Formerly: Forensic Toxicology... Affairs Medical Center, Forensic Toxicology Laboratory, 1 Veterans Drive, Minneapolis, MN 55417, 612-725...-747-3774 (Formerly: University of Texas Medical Branch, Clinical Chemistry Division; UTMB...

  20. Policy for therapeutic acupuncture in an academic health center: a model for standard policy development.

    PubMed

    Myklebust, Monica; Colson, James; Kaufman, Jacqueline; Winsauer, Jeffery; Zhang, Yu Quin; Harris, Richard E

    2006-12-01

    Acupuncture as a therapeutic modality offers multiple applications. Its effectiveness coupled with its general acceptance by conventional health care professionals makes it one of the first complementary and alternative medicine (CAM) modalities to be incorporated in an integrative approach to care. However, few centers that offer acupuncture have written standard policies to regulate its use. This lack of standard policies may impede provision of quality care, serve as a barrier to cross-institutional data collection and clinical application of that data, and may put health care professionals and institutions at risk when credentialing or malpractice liability has not been clearly addressed. Here we present a policy for acupuncture, created by a diverse group of health care professionals at the University of Michigan Health System. It may function as a generalizable template for standard policy development by institutions incorporating acupuncture.

  1. Canadian multicenter laboratory study for standardized second-line antimicrobial susceptibility testing of Mycobacterium tuberculosis.

    PubMed

    Sharma, Meenu; Thibert, Louise; Chedore, Pamela; Shandro, Cary; Jamieson, Frances; Tyrrell, Gregory; Christianson, Sara; Soualhine, Hafid; Wolfe, Joyce

    2011-12-01

    The purpose of this study was to establish a standardized protocol for second-line antimicrobial susceptibility testing of Mycobacterium tuberculosis using the Bactec MGIT 960 system in Canadian laboratories. Four Canadian public health laboratories compared the susceptibility testing results of 9 second-line antimicrobials between the Bactec 460 and Bactec MGIT 960 systems. Based on the data generated, we have established that the Bactec MGIT 960 system provides results comparable to those obtained with the previous Bactec 460 method. The critical concentrations established for the testing of the antimicrobials used are as follows: amikacin, 1 μg/ml; capreomycin, 2.5 μg/ml; ethionamide, 5 μg/ml; kanamycin, 2.5 μg/ml; linezolid, 1 μg/ml; moxifloxacin, 0.25 μg/ml; ofloxacin, 2 μg/ml; p-aminosalicylic acid, 4 μg/ml; rifabutin, 0.5 μg/ml.

  2. Realization of the scale of high fiber optic power at three national standards laboratories

    SciTech Connect

    Envall, Jouni; Andersson, Anne; Petersen, Jan C.; Kaerhae, Petri

    2005-08-20

    Nowadays the transmission powers in optical telecommunication networks are often hundreds of milliwatts. Such high power levels are known to cause several nonlinear effects, thus affecting data transfer. Therefore, accurate measurements of such high power levels are required. The general issues that are to be considered when one is realizing a scale for high fiber optic power are discussed. The scales of the national standards laboratories in Finland, Sweden, and Denmark are described, and the results of a trilateral comparison of these scales are presented. The power range of the comparison was 1-200 mW. The results show that the stated measurement uncertainties of the three laboratories (1.3%-2.9%,k=2) are applicable over this power range.

  3. A roadmap for academic health centers to establish good laboratory practice-compliant infrastructure.

    PubMed

    Adamo, Joan E; Bauer, Gerhard; Berro, Marlene; Burnett, Bruce K; Hartman, Karen A; Masiello, Lisa M; Moorman-White, Diane; Rubinstein, Eric P; Schuff, Kathryn G

    2012-03-01

    Prior to human clinical trials, nonclinical safety and toxicology studies are required to demonstrate that a new product appears safe for human testing; these nonclinical studies are governed by good laboratory practice (GLP) regulations. As academic health centers (AHCs) embrace the charge to increase the translation of basic science research into clinical discoveries, researchers at these institutions increasingly will be conducting GLP-regulated nonclinical studies. Because the consequences for noncompliance are severe and many AHC researchers are unfamiliar with Food and Drug Administration regulations, the authors describe the regulatory requirements for conducting GLP research, including the strict documentation requirements, the necessary personnel training, the importance of study monitoring, and the critical role that compliance oversight plays in the process. They then explain the process that AHCs interested in conducting GLP studies should take before the start of their research program, including conducting a needs assessment and a gap analysis and selecting a model for GLP compliance. Finally, the authors identify and analyze several critical barriers to developing and implementing a GLP-compliant infrastructure at an AHC. Despite these challenges, the capacity to perform such research will help AHCs to build and maintain competitive research programs and to facilitate the successful translation of faculty-initiated research from nonclinical studies to first-in-human clinical trials.

  4. NASA's Corrosion Technology Laboratory at the Kennedy Space Center: Anticipating, Managing, and Preventing Corrosion

    NASA Technical Reports Server (NTRS)

    Calle, Luz Marina

    2015-01-01

    The marine environment at NASAs Kennedy Space Center (KSC) has been documented by ASM International (formerly American Society for Metals) as the most corrosive in North America. With the introduction of the Space Shuttle in 1981, the already highly corrosive conditions at the launch pads were rendered even more severe by the highly corrosive hydrochloric acid (HCl) generated by the solid rocket boosters (SRBs). Numerous failures at the launch pads are caused by corrosion. The structural integrity of ground infrastructure and flight hardware is critical to the success, safety, cost, and sustainability of space missions. NASA has over fifty years of experience dealing with unexpected failures caused by corrosion and has developed expertise in corrosion control in the launch and other environments. The Corrosion Technology Laboratory at KSC evolved, from what started as an atmospheric exposure test site near NASAs launch pads, into a capability that provides technical innovations and engineering services in all areas of corrosion for NASA, external partners, and customers.This paper provides a chronological overview of NASAs role in anticipating, managing, and preventing corrosion in highly corrosive environments. One important challenge in managing and preventing corrosion involves the detrimental impact on humans and the environment of what have been very effective corrosion control strategies. This challenge has motivated the development of new corrosion control technologies that are more effective and environmentally friendly. Strategies for improved corrosion protection and durability can have a huge impact on the economic sustainability of human spaceflight operations.

  5. Measurement of Henry's Law Constants Using Internal Standards: A Quantitative GC Experiment for the Instrumental Analysis or Environmental Chemistry Laboratory

    ERIC Educational Resources Information Center

    Ji, Chang; Boisvert, Susanne M.; Arida, Ann-Marie C.; Day, Shannon E.

    2008-01-01

    An internal standard method applicable to undergraduate instrumental analysis or environmental chemistry laboratory has been designed and tested to determine the Henry's law constants for a series of alkyl nitriles. In this method, a mixture of the analytes and an internal standard is prepared and used to make a standard solution (organic solvent)…

  6. Nanotechnology Laboratory Continues Partnership with FDA and National Institute of Standards and Technology | Poster

    Cancer.gov

    The NCI-funded Nanotechnology Characterization Laboratory (NCL)—a leader in evaluating promising nanomedicines to fight cancer—recently renewed its collaboration with the U.S. Food and Drug Administration (FDA) and the National Institute of Standards and Technology (NIST) to continue its groundbreaking work on characterizing nanomedicines and moving them toward the clinic. In partnership with NIST and the FDA, NCL has laid a solid, scientific foundation for using the power of nanotechnology to increase the potency and target the delivery

  7. A Virtual Geophysical Network: Using Industry Standard Technology to Link Geographically Distributed Sensors and Data Centers

    NASA Astrophysics Data System (ADS)

    Ahern, T. K.; Benson, R. B.; Crotwell, H. P.

    2003-12-01

    The IRIS Data Management System has long supported distributed data centers as a method of providing scientific researchers access to data from seismological networks around the world. For nearly a decade, the NetDC system used email as the method through which users could access data centers located around the globe in a seamless fashion. More recently the IRIS DMC has partnered with the University of South Carolina to develop a new method through which a virtual data center can be created. The Common Object Request Broker Architecture (CORBA) technology is an industry standard distributed computing architecture. Traditionally used by major corporations, IRIS has developed a Data Handling Interface (DHI) system that is capable of connecting services at participating data centers (servers) to applications running on end-users computing platforms (clients). For seismology we have identified three services. 1) A network service that provides information about geophysical observatories around the world such as where the sensors exist, what types of information are recorded on the sensors, and calibration information that allows proper use of the data, 2) an event service that allows applications to access information about earthquakes and seismological events and 3) waveform services that allow users to gain access to seismograms or time series data from other geophysical sensors. Seismological Data Centers operate the servers thereby allowing a variety of client applications to directly access the information at these data centers. Currently IRIS, the U. of South Carolina, UC Berkeley, and a European Data Center (ORFEUS) have been involved in the DHI project. This talk will highlight some of the DHI enabled clients that allow geophysical information to be directly transferred to the clients. Since the data center servers appear with the same interface specification (Interface Definition Language) a client that can talk to one DHI server can talk to any DHI enabled

  8. Current standards of neuropsychological assessment in epilepsy surgery centers across Europe.

    PubMed

    Vogt, Viola Lara; Äikiä, Marja; Del Barrio, Antonio; Boon, Paul; Borbély, Csaba; Bran, Ema; Braun, Kees; Carette, Evelien; Clark, Maria; Cross, Judith Helen; Dimova, Petia; Fabo, Daniel; Foroglou, Nikolaos; Francione, Stefano; Gersamia, Anna; Gil-Nagel, Antonio; Guekht, Alla; Harrison, Sue; Hecimovic, Hrvoje; Heminghyt, Einar; Hirsch, Edouard; Javurkova, Alena; Kälviäinen, Reetta; Kavan, Nicole; Kelemen, Anna; Kimiskidis, Vasilios K; Kirschner, Margarita; Kleitz, Catherine; Kobulashvili, Teia; Kosmidis, Mary H; Kurtish, Selin Yagci; Lesourd, Mathieu; Ljunggren, Sofia; Lossius, Morten Ingvar; Malmgren, Kristina; Mameniskiené, Ruta; Martin-Sanfilippo, Patricia; Marusic, Petr; Miatton, Marijke; Özkara, Çiğdem; Pelle, Federica; Rubboli, Guido; Rudebeck, Sarah; Ryvlin, Philippe; van Schooneveld, Monique; Schmid, Elisabeth; Schmidt, Pia-Magdalena; Seeck, Margitta; Steinhoff, Bernhard J; Shavel-Jessop, Sara; Tarta-Arsene, Oana; Trinka, Eugen; Viggedal, Gerd; Wendling, Anne-Sophie; Witt, Juri-Alexander; Helmstaedter, Christoph

    2017-03-01

    We explored the current practice with respect to the neuropsychological assessment of surgical epilepsy patients in European epilepsy centers, with the aim of harmonizing and establishing common standards. Twenty-six epilepsy centers and members of "E-PILEPSY" (a European pilot network of reference centers in refractory epilepsy and epilepsy surgery), were asked to report the status of neuropsychological assessment in adults and children via two different surveys. There was a consensus among these centers regarding the role of neuropsychology in the presurgical workup. Strong agreement was found on indications (localization, epileptic dysfunctions, adverse drugs effects, and postoperative monitoring) and the domains to be evaluated (memory, attention, executive functions, language, visuospatial skills, intelligence, depression, anxiety, and quality of life). Although 186 different tests are in use throughout these European centers, a core group of tests reflecting a moderate level of agreement could be discerned. Variability exists with regard to indications, protocols, and paradigms for the assessment of hemispheric language dominance. For the tests in use, little published evidence of clinical validity in epilepsy was provided. Participants in the survey reported a need for improvement concerning the validity of the tests, tools for the assessment of everyday functioning and accelerated forgetting, national norms, and test co-normalization. Based on the present survey, we documented a consensus regarding the indications and principles of neuropsychological testing. Despite the variety of tests in use, the survey indicated that there may be a core set of tests chosen based on experience, as well as on published evidence. By combining these findings with the results of an ongoing systematic literature review, we aim for a battery that can be recommended for the use across epilepsy surgical centers in Europe.

  9. Large space antenna communications systems: Integrated Langley Research Center/Jet Propulsion Laboratory development activities. 2: Langley Research Center activities

    NASA Technical Reports Server (NTRS)

    Cambell, T. G.; Bailey, M. C.; Cockrell, C. R.; Beck, F. B.

    1983-01-01

    The electromagnetic analysis activities at the Langley Research Center are resulting in efficient and accurate analytical methods for predicting both far- and near-field radiation characteristics of large offset multiple-beam multiple-aperture mesh reflector antennas. The utilization of aperture integration augmented with Geometrical Theory of Diffraction in analyzing the large reflector antenna system is emphasized.

  10. Laboratory Evaluation of Air Flow Measurement Methods for Residential HVAC Returns for New Instrument Standards

    SciTech Connect

    Walker, Iain; Stratton, Chris

    2015-08-01

    This project improved the accuracy of air flow measurements used in commissioning California heating and air conditioning systems in Title 24 (Building and Appliance Efficiency Standards), thereby improving system performance and efficiency of California residences. The research team at Lawrence Berkeley National Laboratory addressed the issue that typical tools used by contractors in the field to test air flows may not be accurate enough to measure return flows used in Title 24 applications. The team developed guidance on performance of current diagnostics as well as a draft test method for use in future evaluations. The study team prepared a draft test method through ASTM International to determine the uncertainty of air flow measurements at residential heating ventilation and air conditioning returns and other terminals. This test method, when finalized, can be used by the Energy Commission and other entities to specify required accuracy of measurement devices used to show compliance with standards.

  11. Standardized and flexible eight colour flow cytometry panels harmonized between different laboratories to study human NK cell phenotype and function.

    PubMed

    Veluchamy, John P; Delso-Vallejo, María; Kok, Nina; Bohme, Fenna; Seggewiss-Bernhardt, Ruth; van der Vliet, Hans J; de Gruijl, Tanja D; Huppert, Volker; Spanholtz, Jan

    2017-03-10

    Advancements in multi-colour fluorescence activated cell sorting (FACS) panel warrant harmonized procedures to obtain comparable data between various laboratories. The intensifying clinical exploration of Natural Killer (NK) cell-based immunotherapy demands standardized and harmonized NK cell FACS panels and acquisition protocols. Eight colour FACS panels were designed to study human NK cell phenotype and function within peripheral blood mononuclear cells (PBMC). The panels were designed around fixed backbone markers and channels, covering antigens for non-NK lineage exclusion (CD3, TCRγδ, CD19, CD14, SYTOX(®) Blue) and NK cell selection (CD45, CD56, CD16), complemented with variable drop-in markers/channels to study NK cell phenotype (NKG2A, NKG2C, NKG2D and KIR2D) or NK cell function and activation (CD25, NKp44 and CD107a). Harmonized FACS set-up and data analysis for three different flow cytometers has been established, leading to highly comparable and reproducible data sets using the same PBMC reference samples (n = 6). Further studies of NK cells in fresh or cryopreserved PBMC samples (n = 12) confirmed that freezing and thawing of PBMC samples did not significantly affect NK phenotype or function. In conclusion, our data demonstrate that cryopreserved PBMC samples analysed by standardized FACS panels and harmonized analysis protocols will generate highly reliable data sets for multi-center clinical trials under validated conditions.

  12. Standardized and flexible eight colour flow cytometry panels harmonized between different laboratories to study human NK cell phenotype and function

    PubMed Central

    Veluchamy, John P.; Delso-Vallejo, María; Kok, Nina; Bohme, Fenna; Seggewiss-Bernhardt, Ruth; van der Vliet, Hans J.; de Gruijl, Tanja D.; Huppert, Volker; Spanholtz, Jan

    2017-01-01

    Advancements in multi-colour fluorescence activated cell sorting (FACS) panel warrant harmonized procedures to obtain comparable data between various laboratories. The intensifying clinical exploration of Natural Killer (NK) cell-based immunotherapy demands standardized and harmonized NK cell FACS panels and acquisition protocols. Eight colour FACS panels were designed to study human NK cell phenotype and function within peripheral blood mononuclear cells (PBMC). The panels were designed around fixed backbone markers and channels, covering antigens for non-NK lineage exclusion (CD3, TCRγδ, CD19, CD14, SYTOX® Blue) and NK cell selection (CD45, CD56, CD16), complemented with variable drop-in markers/channels to study NK cell phenotype (NKG2A, NKG2C, NKG2D and KIR2D) or NK cell function and activation (CD25, NKp44 and CD107a). Harmonized FACS set-up and data analysis for three different flow cytometers has been established, leading to highly comparable and reproducible data sets using the same PBMC reference samples (n = 6). Further studies of NK cells in fresh or cryopreserved PBMC samples (n = 12) confirmed that freezing and thawing of PBMC samples did not significantly affect NK phenotype or function. In conclusion, our data demonstrate that cryopreserved PBMC samples analysed by standardized FACS panels and harmonized analysis protocols will generate highly reliable data sets for multi-center clinical trials under validated conditions. PMID:28281564

  13. Implementing a perpetual anesthesia setup standardized for the trauma room in a level I trauma center.

    PubMed

    Faircloth, Amanda C; Ford, Mary B

    2013-02-01

    The trauma room in a level I trauma center is a dynamic environment that provides little room for error. Significant variability can exist if anesthesia providers set up the room differently. Standardization provides a system that is consistent, reliable, and cost-effective. This study examines the process of creating and implementing a standardized anesthesia setup in the trauma room of a level I trauma center. As a result of this study, the medication cart and airway setups have been standardized. Providers are encouraged to only draw up medications that will be immediately used and to ensure that prefilled syringes have been incorporated into the pharmacy formulary. Using the EZ Endo prestyleted endotracheal tube (ETT) vs a regular ETT with stylet has yielded an annual cost savings of $2,673. Ensuring that items such as an esophageal temperature probe, humidifier, and nasogastric tube are available but unopened has provided a savings of $1,989.25 per year. The reservoir bag has been changed to a latex-free bag, and 3 central line kits including an arterial line kit are routinely stocked. An ultrasound machine dedicated for central line access, GlideScope, rapid fluid infuser, and Airtraq laryngoscope have all been incorporated into the permanent setup in the trauma room.

  14. Tu-144LL SST Flying Laboratory on Taxiway at Zhukovsky Air Development Center near Moscow, Russia

    NASA Technical Reports Server (NTRS)

    1998-01-01

    The sleek lines of the Tupolev Tu-144LL are evident as it sits on the taxiway at the Zhukovsky Air Development Center near Moscow, Russia. NASA teamed with American and Russian aerospace industries for an extended period in a joint international research program featuring the Russian-built Tu-144LL supersonic aircraft. The object of the program was to develop technologies for a proposed future second-generation supersonic airliner to be developed in the 21st Century. The aircraft's initial flight phase began in June 1996 and concluded in February 1998 after 19 research flights. A shorter follow-on program involving seven flights began in September 1998 and concluded in April 1999. All flights were conducted in Russia from Tupolev's facility at the Zhukovsky Air Development Center near Moscow. The centerpiece of the research program was the Tu 144LL, a first-generation Russian supersonic jetliner that was modified by its developer/builder, Tupolev ANTK (aviatsionnyy nauchno-tekhnicheskiy kompleks-roughly, aviation technical complex), into a flying laboratory for supersonic research. Using the Tu-144LL to conduct flight research experiments, researchers compared full-scale supersonic aircraft flight data with results from models in wind tunnels, computer-aided techniques, and other flight tests. The experiments provided unique aerodynamic, structures, acoustics, and operating environment data on supersonic passenger aircraft. Data collected from the research program was being used to develop the technology base for a proposed future American-built supersonic jetliner. Although actual development of such an advanced supersonic transport (SST) is currently on hold, commercial aviation experts estimate that a market for up to 500 such aircraft could develop by the third decade of the 21st Century. The Tu-144LL used in the NASA-sponsored research program was a 'D' model with different engines than were used in production-model aircraft. Fifty experiments were proposed

  15. Pain management standards in the eighth edition of the Guide for the Care and Use of Laboratory Animals.

    PubMed

    Carbone, Larry

    2012-05-01

    The eighth edition Guide for the Care and Use of Laboratory Animals sets standards for diverse laboratory animal care and use practices. It frames its standards as performance, engineering, and practice standards, with a strong emphasis on performance standards, allowing for multiple routes to clearly defined outcomes. Standards intended to be upheld rigorously are indicated through the use of must in the description, and those accommodating more flexibility are indicated through may and should statements. With respect to pain management standards, a fourth type of standard-the jurisdictional standard-has been prevalent through all 8 editions of the Guide. Under jurisdictional standards, specific methods and outcomes for measuring, preventing, or alleviating pain are not detailed, but the various jurisdictions of veterinarian, investigator, and IACUC are elaborated. Although data on pain management in laboratory animals has expanded greatly since the 1996 Guide, the eighth (2011) edition does not contain major new standards or guidance regarding animal pain management. Requirements for veterinary and IACUC involvement remain as in prior editions, and the duty of veterinarians and scientists to stay abreast of new developments is expected to drive refinement of animal pain management institution by institution. The current article details selected specific pain management standards in the 2011 Guide, lists topics in pain management for which the Guide does not set clear standards, and suggests possible standards for those topics.

  16. Creating Better Child Care Jobs: Model Work Standards for Teaching Staff in Center-Based Child Care.

    ERIC Educational Resources Information Center

    Center for the Child Care Workforce, Washington, DC.

    This document presents model work standards articulating components of the child care center-based work environment that enable teachers to do their jobs well. These standards establish criteria to assess child care work environments and identify areas to improve in order to assure good jobs for adults and good care for children. The standards are…

  17. Design and verification of the shielding around the new Neutron Standards Laboratory (LPN) at CIEMAT.

    PubMed

    Méndez-Villafañe, R; Guerrero, J E; Embid, M; Fernández, R; Grandio, R; Pérez-Cejuela, P; Márquez, J L; Alvarez, F; Ortego, P

    2014-10-01

    The construction of the new Neutron Standards Laboratory at CIEMAT (Laboratorio de Patrones Neutrónicos) has been finalised and is ready to provide service. The facility is an ∼8 m×8 m×8 m irradiation vault, following the International Organization for Standardization 8529 recommendations. It relies on several neutron sources: a 5-GBq (5.8× 10(8) s(-1)) (252)Cf source and two (241)Am-Be neutron sources (185 and 11.1 GBq). The irradiation point is located 4 m over the ground level and in the geometrical centre of the room. Each neutron source can be moved remotely from its storage position inside a water pool to the irradiation point. Prior to this, an important task to design the neutron shielding and to choose the most appropriate materials has been developed by the Radiological Security Unit and the Ionizing Radiations Metrology Laboratory. MCNPX was chosen to simulate the irradiation facility. With this information the walls were built with a thickness of 125 cm. Special attention was put on the weak points (main door, air conditioning system, etc.) so that the ambient dose outside the facility was below the regulatory limits. Finally, the Radiation Protection Unit carried out a set of measurements in specific points around the installation with an LB6411 neutron monitor and a Reuter-Stokes high-pressure ion chamber to verify experimentally the results of the simulation.

  18. Toward an interim standard for patient-centered knowledge-access.

    PubMed Central

    Tuttle, M. S.; Sherertz, D. D.; Fagan, L. M.; Carlson, R. W.; Cole, W. G.; Schipma, P. B.; Nelson, S. J.

    1993-01-01

    Most care-giver "knowledge" needs arise at the point of care and are "patient-centered." Many of these knowledge needs can be met using existing on-line knowledge sources, but the process is too time-consuming, currently, for even the computer-proficient. We are developing a set of public domain standards aimed at bringing potentially relevant knowledge to the point of care in a straight-forward and timely fashion. The standards will a) make use of selected items from a Computer-based Patient Record (CPR), e.g., a diagnosis and measure of severity, b) anticipate certain care-giver knowledge needs, e.g., "therapy," "protocols," "complications," and c) try to satisfy those needs from available knowledge sources, e.g., knowledge-bases, citation databases, practice guidelines, and on-line textbooks. The standards will use templates, i.e., fill-in-the-blank structures, to anticipate knowledge needs and UMLS Metathesaurus enhancements to represent the content of knowledge sources. Together, the standards will form the specification for a "Knowledge-Server" (KS) designed to be accessed from any CPR system. Plans are in place to test an interim version of this specification in the context of medical oncology. We are accumulating anecdotal evidence that a KS operating in conjunction with a CPR is much more compelling to users than either a CPR or a KS operating alone. PMID:8130537

  19. 76 FR 5379 - Clinical Laboratory Improvement Advisory Committee (CLIAC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-31

    ..., revisions to the standards under which clinical laboratories are regulated; the impact on medical and... Clinical Laboratory Workforce; the National Institutes of Health Genetic Test Registry design and responses... HUMAN SERVICES Centers for Disease Control and Prevention Clinical Laboratory Improvement...

  20. Exposure to hazardous substances in a standard molecular biology laboratory environment: evaluation of exposures in IARC laboratories.

    PubMed

    Chapot, Brigitte; Secretan, Béatrice; Robert, Annie; Hainaut, Pierre

    2009-07-01

    Working in a molecular biology laboratory environment implies regular exposure to a wide range of hazardous substances. Several recent studies have shown that laboratory workers may have an elevated risk of certain cancers. Data on the nature and frequency of exposures in such settings are scanty. The frequency of use of 163 agents by staff working in molecular biology laboratories was evaluated over a period of 4 years by self-administered questionnaire. Of the agents listed, ethanol was used by the largest proportion of staff (70%), followed by ethidium bromide (55%). Individual patterns of use showed three patterns, namely (i) frequent use of a narrow range of products, (ii) occasional use of a wide range of products, and (iii) frequent and occasional use of an intermediate range of products. Among known or suspected carcinogens (International Agency for Research on Cancer Group 1 and 2A, respectively), those most frequently used included formaldehyde (17%), oncogenic viruses (4%), and acrylamide (32%). The type of exposure encountered in research laboratories is extremely diverse. Few carcinogenic agents are used frequently but many laboratory workers may be exposed occasionally to known human carcinogens. In addition, many of the chemicals handled by staff represent a health hazard. The results enabled the staff physician to develop an individual approach to medical surveillance and to draw a personal history of occupational exposures for laboratory staff.

  1. Nidus Center for Scientific Enterprise, St. Louis, Missouri; Laboratories for the 21st Century: Case Studies (Revised)

    SciTech Connect

    Not Available

    2005-03-01

    This publication is one in an ongoing series of case studies for "Laboratories for the 21st Century," a joint program of the U.S. Environmental Protection Agency and the U.S. Department of Energy Federal Energy Management Program. It is intended for all those who plan, design, and construct public and private-sector laboratory buildings. This study describes how the Nidus Center, a nonprofit incubator for life sciences and plan biotechnology established by Monsanto Company, employs daylighting, an energy-efficient mechanical system featuring energy recovery, and water conservation practices, among others, to save energy and money and help conserve natural resources.

  2. Sandia National Laboratories Facilities Management and Operations Center Design Standards Manual

    SciTech Connect

    Fattor, Steven

    2014-06-01

    The manual contains general requirements that apply to nonnuclear and nonexplosive facilities. For design and construction requirements for modifications to nuclear or explosive facilities, see the project-specific design requirements noted in the Design Criteria.

  3. The Astromaterials X-Ray Computed Tomography Laboratory at Johnson Space Center

    NASA Technical Reports Server (NTRS)

    Zeigler, R. A.; Coleff, D. M.; McCubbin, F. M.

    2017-01-01

    The Astromaterials Acquisition and Curation Office at NASA's Johnson Space Center (hereafter JSC curation) is the past, present, and future home of all of NASA's astromaterials sample collections. JSC curation currently houses all or part of nine different sample collections: (1) Apollo samples (1969), (2) Lunar samples (1972), (3) Antarctic meteorites (1976), (4) Cosmic Dust particles (1981), (5) Microparticle Impact Collection (1985), (6) Genesis solar wind atoms (2004); (7) Stardust comet Wild-2 particles (2006), (8) Stardust interstellar particles (2006), and (9) Hayabusa asteroid Itokawa particles (2010). Each sample collection is housed in a dedicated clean room, or suite of clean rooms, that is tailored to the requirements of that sample collection. Our primary goals are to maintain the long-term integrity of the samples and ensure that the samples are distributed for scientific study in a fair, timely, and responsible manner, thus maximizing the return on each sample. Part of the curation process is planning for the future, and we also perform fundamental research in advanced curation initiatives. Advanced Curation is tasked with developing procedures, technology, and data sets necessary for curating new types of sample collections, or getting new results from existing sample collections [2]. We are (and have been) planning for future curation, including cold curation, extended curation of ices and volatiles, curation of samples with special chemical considerations such as perchlorate-rich samples, and curation of organically- and biologically-sensitive samples. As part of these advanced curation efforts we are augmenting our analytical facilities as well. A micro X-Ray computed tomography (micro-XCT) laboratory dedicated to the study of astromaterials will be coming online this spring within the JSC Curation office, and we plan to add additional facilities that will enable nondestructive (or minimally-destructive) analyses of astromaterials in the near

  4. The Levels of Inquiry Matrix in developing written lesson plans for laboratory-centered science instruction

    NASA Astrophysics Data System (ADS)

    Smith, William Robert

    This study examines the effectiveness of a full-semester inservice program in reforming the lesson planning practices of science teachers. The Levels of Inquiry Matrix was used as a model of inquiry focused, laboratory centered science instruction throughout the inservice program. Effective planning is crucial to the development and execution of good instruction and the Levels of Inquiry Matrix may serve as a tool toward reaching this goal. Thirty practicing science teachers completed courses designed to reform their teaching toward a greater emphasis on inquiry. The inservice teachers completed a background survey and wrote three lesson plans. The first was prepared prior to course treatment, the second was prepared at mid-course, and the third was prepared as a final project. A set of "Guidelines for Using the Levels of Inquiry Matrix" was prepared to aid in the objective classification of the level of inquiry planned for in each written lesson plan. Also, a list of permutations of the Levels of Inquiry Matrix was developed in order to classify the level of inquiry demonstrated by written lesson plans that did not match a sequence of student and teacher responsibility found on the Levels of Inquiry Matrix. The study demonstrated that inservice teachers in one of the two courses significantly improved in ability to write lesson plans that reflect greater levels of inquiry as defined by the Levels of Inquiry Matrix. The inservice teachers, in both courses, believed that they were planning for higher levels of inquiry than they actually demonstrated through the written lesson plans. They also believed they were improving in their ability to write lesson plans that reflected higher levels of inquiry whether they actually achieved this or not. No correlation was found between the inservice teachers' years of experience teaching science, educational background, certification status and the level of inquiry demonstrated by the lesson plans. Finally, the Inquiry Lesson

  5. 76 FR 38550 - Technical Standard DOE-STD-1095-2011, Department of Energy Laboratory Accreditation for External...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-01

    ...The Department of Energy (DOE or the Department) is issuing Technical Standard DOE-STD-1095-2011, Department of Energy Laboratory Accreditation for External Dosimetry, January 2011. This standard provides updated technical criteria for performance testing for, and provides a requirement for onsite quality assurance assessments of, whole body and extremity dosimetry programs in use at DOE......

  6. ISO 18812--a worldwide standard for the online-connection of analytical instruments to laboratory information systems.

    PubMed

    Fraterman, Arno

    2004-01-01

    In the past there were many attempts to standardize the interface from analytical instruments to laboratory-information-systems. Most of these attempts were national. The international standardisation bodies CEN and ISO have now developed an international standard that is presented here.

  7. Rain simulator as a standardized laboratory measurement of soil structural stability

    NASA Astrophysics Data System (ADS)

    Iglesias, Luz; Cancelo González, Javier; Benito, Elena; Álvarez, Manuel; Barral, Maria Teresa; Díaz-Fierros, Francisco

    2010-05-01

    Rainfall simulations are used since the 30's by scientist and technicians to study the soil erosion and soil hydrology. The basis of the rainfall simulation is that can reproduce the natural soil degradation processes, more accurately than the traditional methods used for the determination of structural stability. A rainfall simulator was built in 2006 based on those made by Guitián and Méndez (1961), and Morin (1967), to obtain standardized laboratory measurements of soil structural stability and a final implementation were made in the rainfall simulator to incorporate a intermittent fan-like water yet system with four sieves of 250 micrometres where the soil samples can be placed, and allow the simultaneous measurement of soil losses in the samples. Data obtained in the rainfall simulator, using different soils of the study basins, are related with the Ig Henin index and the results of the Emerson structural stability test. At the same time with the laboratory test, 10 water sampling surveys were carried out during the hydrological years 2004/05 and 2005/06, in two basins located in the humid region of NW Spain belonging to the Anllons River basin, one of the main basins of Galicia-Costa, that has been subject of detailed hydrological studies since 2000 (Rial, M., 2007 and Devesa, R., 2009) and had continuous records of streamflow. The selected subbasins have 57,62 and 50,05 square kilometres respectively, and presents significative geological differences; being one of them formed, mainly, by schists and a lower area with granites and, the other one formed mainly by gabbros. The suspended sediments in the samples were separated by centrifugation and weighted in the laboratory to study the possible relationship between soil losses in the rainfall simulations and the sediment fluxes in the river. The analysis revealed a good relationship between the sediments delivery to the streams and soil losses measured in the rainfall simulations.

  8. Standard Hydrogen Test Protocols for the NREL Sensor Testing Laboratory (Brochure)

    SciTech Connect

    Not Available

    2011-12-01

    This brochure summarizes the test protocols used in the NREL Hydrogen Sensor Test Laboratory for the quantitative assessment of critical analytical performance specifications for hydrogen sensors. Researchers at the NREL Hydrogen Safety Sensor Test Laboratory developed a variety of test protocols to quantitatively assess critical analytical performance specifications for hydrogen sensors. Many are similar to, but typically more rigorous than, the test procedures mandated by ISO Standard 26142 (Hydrogen Detector for Stationary Applications). Specific protocols were developed for linear range, short-term stability, and the impact of fluctuations in temperature (T), pressure (P), relative humidity (RH), and chemical environment. Specialized tests (e.g., oxygen requirement) may also be performed. Hydrogen safety sensors selected for evaluation are subjected to a thorough regimen of test protocols, as described. Sensor testing is performed at NREL on custom-built sensor test fixtures. Environmental parameters such as T, P, RH, and gas composition are rigorously controlled and monitored. The NREL evaluations are performed on commercial hydrogen detectors, on emerging sensing technologies, and for end users to validate sensor performance for specific application needs. Test results and data are shared with the manufacturer or client via summary reports, teleconference phone calls, and, when appropriate, site visits to manufacturer facilities. Client representatives may also monitor NREL's operation while their technologies are being tested. Manufacturers may use test data to illustrate the analytical capability of their technologies and, more importantly, to guide future developments. NREL uses the data to assess technology gaps and deployment considerations. Per NREL Sensor Testing Laboratory policy, test results are treated as proprietary and are not shared with other manufacturers or other entities without permission. The data may be used by NREL in open publications

  9. Open standards for cascade models for RHIC: Volume 1. Proceedings of RIKEN BNL Research Center workshop

    SciTech Connect

    1997-10-01

    It is widely recognized that cascade models are potentially effective and powerful tools for interpreting and predicting multi-particle observables in heavy ion physics. However, the lack of common standards, documentation, version control, and accessibility have made it difficult to apply objective scientific criteria for evaluating the many physical and algorithmic assumptions or even to reproduce some published results. The first RIKEN Research Center workshop was proposed by Yang Pang to address this problem by establishing open standards for original codes for applications to nuclear collisions at RHIC energies. The aim of this first workshop is: (1) to prepare a WWW depository site for original source codes and detailed documentation with examples; (2) to develop and perform standardized test for the models such as Lorentz invariance, kinetic theory comparisons, and thermodynamic simulations; (3) to publish a compilation of results of the above work in a journal e.g., ``Heavy Ion Physics``; and (4) to establish a policy statement on a set of minimal requirements for inclusion in the OSCAR-WWW depository.

  10. Data Format Standardization of Space Weather Model Output at the Community Coordinated Modeling Center

    NASA Technical Reports Server (NTRS)

    Maddox, M.; Rastatter, L.; Hesse, M.

    2005-01-01

    The disparate nature of space weather model output provides many challenges with regards to the portability and reuse of not only the data itself, but also any tools that are developed for analysis and visualization. We are developing and implementing a comprehensive data format standardization methodology that allows heterogeneous model output data to be stored uniformly in any common science data format. We will discuss our approach to identifying core meta-data elements that can be used to supplement raw model output data, thus creating self-descriptive files. The meta-data should also contain information describing the simulation grid. This will ultimately assists in the development of efficient data access tools capable of extracting data at any given point and time. We will also discuss our experiences standardizing the output of two global magnetospheric models, and how we plan to apply similar procedures when standardizing the output of the solar, heliospheric, and ionospheric models that are also currently hosted at the Community Coordinated Modeling Center.

  11. Blood Cholesterol Measurement in Clinical Laboratories in the United States. Current Status. A Report from the Laboratory Standardization Panel of the National Cholesterol Education Program.

    ERIC Educational Resources Information Center

    National Heart, Lung, and Blood Inst. (DHHS/NIH), Bethesda, MD.

    Precise and accurate cholesterol measurements are required to identify and treat individuals with high blood cholesterol levels. However, the current state of reliability of blood cholesterol measurements suggests that considerable inaccuracy in cholesterol testing exists. This report describes the Laboratory Standardization Panel findings on the…

  12. Ice Crystal Icing Engine Testing in the NASA Glenn Research Center's Propulsion Systems Laboratory (PSL): Altitude Investigation

    NASA Technical Reports Server (NTRS)

    Oliver, Michael J.

    2015-01-01

    The National Aeronautics and Space Administration conducted a full scale ice crystal icing turbofan engine test in the NASA Glenn Research Centers Propulsion Systems Laboratory (PSL) Facility in February 2013. Honeywell Engines supplied the test article, an obsolete, unmodified Lycoming ALF502-R5 turbofan engine serial number LF01 that experienced an un-commanded loss of thrust event while operating at certain high altitude ice crystal icing conditions. These known conditions were duplicated in the PSL for this testing.

  13. Department of Energy’s ARM Climate Research Facility External Data Center Operations Plan Located At Brookhaven National Laboratory

    SciTech Connect

    Cialella, A.; Gregory, L.; Lazar, K.; Liang, M.; Ma, L.; Tilp, A.; Wagener, R.

    2015-05-01

    The External Data Center (XDC) Operations Plan describes the activities performed to manage the XDC, located at Brookhaven National Laboratory (BNL), for the Department of Energy’s Atmospheric Radiation Measurement (ARM) Climate Research Facility. It includes all ARM infrastructure activities performed by the Data Management and Software Engineering Group (DMSE) at BNL. This plan establishes a baseline of expectation within the ARM Operations Management for the group managing the XDC.

  14. Development and status of data quality assurance program at NASA Langley research center: Toward national standards

    NASA Technical Reports Server (NTRS)

    Hemsch, Michael J.

    1996-01-01

    As part of a continuing effort to re-engineer the wind tunnel testing process, a comprehensive data quality assurance program is being established at NASA Langley Research Center (LaRC). The ultimate goal of the program is routing provision of tunnel-to-tunnel reproducibility with total uncertainty levels acceptable for test and evaluation of civilian transports. The operational elements for reaching such levels of reproducibility are: (1) statistical control, which provides long term measurement uncertainty predictability and a base for continuous improvement, (2) measurement uncertainty prediction, which provides test designs that can meet data quality expectations with the system's predictable variation, and (3) national standards, which provide a means for resolving tunnel-to-tunnel differences. The paper presents the LaRC design for the program and discusses the process of implementation.

  15. Ethical and methodological standards for laboratory and medical biological rhythm research.

    PubMed

    Portaluppi, Francesco; Touitou, Yvan; Smolensky, Michael H

    2008-11-01

    The main objectives of this article are to update the ethical standards for the conduct of human and animal biological rhythm research and recommend essential elements for quality chronobiological research information, which should be especially useful for new investigators of the rhythms of life. A secondary objective is to provide for those with an interest in the results of chronobiology investigations, but who might be unfamiliar with the field, an introduction to the basic methods and standards of biological rhythm research and time series data analysis. The journal and its editors endorse compliance of all investigators to the principles of the Declaration of Helsinki of the World Medical Association, which relate to the conduct of ethical research on human beings, and the Guide for the Care and Use of Laboratory Animals of the Institute for Laboratory Animal Research of the National Research Council, which relate to the conduct of ethical research on laboratory and other animals. The editors and the readers of the journal expect the authors of submitted manuscripts to have adhered to the ethical standards dictated by local, national, and international laws and regulations in the conduct of investigations and to be unbiased and accurate in reporting never-before-published research findings. Authors of scientific papers are required to disclose all potential conflicts of interest, particularly when the research is funded in part or in full by the medical and pharmaceutical industry, when the authors are stock-holders of the company that manufactures or markets the products under study, or when the authors are a recent or current paid consultant to the involved company. It is the responsibility of the authors of submitted manuscripts to clearly present sufficient detail about the synchronizer schedule of the studied subjects (i.e., the sleep-wake schedule, ambient light-dark cycle, intensity and spectrum of ambient light exposure, seasons when the research was

  16. Changes across Three Editions of "The Suicidal Patient: Clinical and Legal Standards of Care": Relevance to Counseling Centers

    ERIC Educational Resources Information Center

    Polychronis, Paul D.

    2017-01-01

    Treating suicidality is one of the most challenging situations managed by college and university counseling centers. The first edition of Bongar's (1991) "The Suicidal Patient: Clinical and Legal Standards of Care," a compendium of empirical knowledge and clinical research regarding standard of care in the treatment of suicidality, was…

  17. EBMT transplant centers with FACT-JACIE accreditation have significantly better compliance with related donor care standards

    PubMed Central

    Anthias, Chloe; O'Donnell, Paul V; Kiefer, Deidre M; Yared, Jean; Norkin, Maxim; Anderlini, Paolo; Savani, Bipin N; Diaz, Miguel A; Bitan, Menachem; Halter, Joerg P; Logan, Brent R; Switzer, Galen E; Pulsipher, Michael A; Confer, Dennis L; Shaw, Bronwen E

    2016-01-01

    Previous studies have identified healthcare practices that may place undue pressure on related donors (RDs) of hematopoietic cell products, and an increase in serious adverse events associated with morbidities in this population. As a result, specific requirements to safeguard RD health have been introduced to FACT-JACIE Standards, but the impact of accreditation on RD care has not previously been evaluated. A survey of transplant program directors of EBMT member centers was conducted by the Donor Health and Safety Working Committee of the Center for International Blood and Marrow Transplant Research (CIBMTR) to test the hypothesis that RD care in FACT-JACIE accredited centers is more closely aligned with international consensus donor care recommendations than RD care delivered in centers without accreditation. Responses were received from 39% of 304 centers. Our results show that practice in accredited centers was much closer to recommended standards as compared to non-accredited centers. Specifically, a higher percentage of accredited centers use eligibility criteria to assess RDs (93% versus 78%; P=0.02) and a lower percentage have a single physician simultaneously responsible for a RD and their recipient (14% versus 35%; P=0.008). In contrast, where regulatory standards do not exist, both accredited and non-accredited centers fell short of accepted best practice. These results raise concerns that despite improvements in care, current practice can place undue pressure on donors, and may increase the risk of donation-associated adverse events. We recommend measures to address these issues through enhancement of regulatory standards as well as national initiatives to standardize RD care. PMID:26597079

  18. Validation Ice Crystal Icing Engine Test in the Propulsion Systems Laboratory at NASA Glenn Research Center

    NASA Technical Reports Server (NTRS)

    Oliver, Michael J.

    2014-01-01

    The Propulsion Systems Laboratory (PSL) is an existing altitude simulation jet engine test facility located at NASA Glenn Research Center in Clevleand, OH. It was modified in 2012 with the integration of an ice crystal cloud generation system. This paper documents the inaugural ice crystal cloud test in PSLthe first ever full scale, high altitude ice crystal cloud turbofan engine test to be conducted in a ground based facility. The test article was a Lycoming ALF502-R5 high bypass turbofan engine, serial number LF01. The objectives of the test were to validate the PSL ice crystal cloud calibration and engine testing methodologies by demonstrating the capability to calibrate and duplicate known flight test events that occurred on the same LF01 engine and to generate engine data to support fundamental and computational research to investigate and better understand the physics of ice crystal icing in a turbofan engine environment while duplicating known revenue service events and conducting test points while varying facility and engine parameters. During PSL calibration testing it was discovered than heated probes installed through tunnel sidewalls experienced ice buildup aft of their location due to ice crystals impinging upon them, melting and running back. Filtered city water was used in the cloud generation nozzle system to provide ice crystal nucleation sites. This resulted in mineralization forming on flow path hardware that led to a chronic degradation of performance during the month long test. Lacking internal flow path cameras, the response of thermocouples along the flow path was interpreted as ice building up. Using this interpretation, a strong correlation between total water content (TWC) and a weaker correlation between median volumetric diameter (MVD) of the ice crystal cloud and the rate of ice buildup along the instrumented flow path was identified. For this test article the engine anti-ice system was required to be turned on before ice crystal icing

  19. Validation Ice Crystal Icing Engine Test in the Propulsion Systems Laboratory at NASA Glenn Research Center

    NASA Technical Reports Server (NTRS)

    Oliver, Michael J.

    2014-01-01

    The Propulsion Systems Laboratory (PSL) is an existing altitude simulation jet engine test facility located at NASA Glenn Research Center in Cleveland, OH. It was modified in 2012 with the integration of an ice crystal cloud generation system. This paper documents the inaugural ice crystal cloud test in PSL--the first ever full scale, high altitude ice crystal cloud turbofan engine test to be conducted in a ground based facility. The test article was a Lycoming ALF502-R5 high bypass turbofan engine, serial number LF01. The objectives of the test were to validate the PSL ice crystal cloud calibration and engine testing methodologies by demonstrating the capability to calibrate and duplicate known flight test events that occurred on the same LF01 engine and to generate engine data to support fundamental and computational research to investigate and better understand the physics of ice crystal icing in a turbofan engine environment while duplicating known revenue service events and conducting test points while varying facility and engine parameters. During PSL calibration testing it was discovered than heated probes installed through tunnel sidewalls experienced ice buildup aft of their location due to ice crystals impinging upon them, melting and running back. Filtered city water was used in the cloud generation nozzle system to provide ice crystal nucleation sites. This resulted in mineralization forming on flow path hardware that led to a chronic degradation of performance during the month long test. Lacking internal flow path cameras, the response of thermocouples along the flow path was interpreted as ice building up. Using this interpretation, a strong correlation between total water content (TWC) and a weaker correlation between median volumetric diameter (MVD) of the ice crystal cloud and the rate of ice buildup along the instrumented flow path was identified. For this test article the engine anti-ice system was required to be turned on before ice crystal

  20. [Harmonization procedures directed toward clinical trials in laboratory medicine at the National Cancer Center Hospital].

    PubMed

    Ozeki, Mitsuru; Shioya, Kana; Furuta, Koh

    2009-09-01

    Recent advances in pharmacology and molecular sciences made it possible to develop drugs for patients with various maladies. Frustration has existed concerning the delayed provision of these drugs for routine practices in the clinical field. To correct this problem, the importance of clinical trials is increasing. Although there exists a strong demand for participation of clinical laboratories in clinical trials, an awkward attitude in clinical laboratories frustrates those performing clinical trials. We are attempting to correct this problem by introducing our experience with harmonization procedures directed toward clinical trials in laboratory medicine in general. First we described the current status of clinical trials in our hospital. Then we will show personnel in need for clinical trials. Finally we describe in detail our clinical trial procedures. We focus particularly on three aspects of participation in clinical trials: pre-analytical, analytical, and post analytical. Additionally we describe the problems and perspectives in clinical trials by giving special reference to the clinical laboratories in general through discussion with various personnel and specialists. Our goal in the field of laboratory medicine is to benefit patients through the establishment of a harmony between clinical trials and clinical laboratories.

  1. National Fuel Cell Technology Evaluation Center (NFCTEC); (NREL) National Renewable Energy Laboratory

    SciTech Connect

    Kurtz, Jennifer; Sprik, Sam

    2014-03-11

    This presentation gives an overview of the National Fuel Cell Technology Evaluation Center (NFCTEC), describes how NFCTEC benefits the hydrogen and fuel cell community, and introduces a new fuel cell cost/price aggregation project.

  2. Annual report procurement and logistics management center Sandia National Laboratories fiscal year 2002.

    SciTech Connect

    Palmer, David L.

    2003-05-01

    This report summarizes the purchasing and transportation activities of the Procurement and Logistics Management Center for Fiscal Year 2002. Activities for both the New Mexico and California locations are included.

  3. [Audit of clinical trials in Argentina. Assessment of standardized operational procedures in 12 centers].

    PubMed

    Forti, I N; Barousse, A P; Bernabó, J G

    1991-01-01

    The purpose of these audits was to ensure the quality, integrity and validity of investigational data. Audits were performed by control of compliance to standard operational procedures (SOPs) for Good Clinical Practice (GCP). Guidelines were proposed and established by the Food and Drug Administration (FDA) in 1977-1979 and adopted by several countries of the European Community in 1987-1989 and 1990. In Argentina, 12 on site audits of clinical trials performed between 1987 and 1990, were carried out. Basic data of GCP, audited in 58 out of 153 patients included in 12 different centers, were: protection of individual rights, compliance to standard operational procedures, adverse event reports, access to original investigational data and source document archives. The analysis of all audited data showed that patient case reports form recorded findings are credible and reliable and that researchers and monitors had conducted the study with an acceptable level in accordance to SOPs of good clinical practice. Otherwise, several in need of change to obtain better clinical data were identified: ethical committees, written informed consent, protocol adherence, data record, drug accountability, document source archives and the necessity of a thorough theorical and practical training on SOPs for GCP for researchers and monitors of clinical trials.

  4. Procedures of Exercise Physiology Laboratories

    NASA Technical Reports Server (NTRS)

    Bishop, Phillip A.; Fortney, Suzanne; Greenisen, Michael; Siconolfi, Steven F.; Bamman, Marcas M.; Moore, Alan D., Jr.; Squires, William

    1998-01-01

    This manual describes the laboratory methods used to collect flight crew physiological performance data at the Johnson Space Center. The Exercise Countermeasures Project Laboratory is a standard physiology laboratory; only the application to the study of human physiological adaptations to spaceflight is unique. In the absence of any other recently published laboratory manual, this manual should be a useful document staffs and students of other laboratories.

  5. Differences in Anticipatory Behaviour between Rats (Rattus norvegicus) Housed in Standard versus Semi-Naturalistic Laboratory Environments

    PubMed Central

    Makowska, I. Joanna; Weary, Daniel M.

    2016-01-01

    Laboratory rats are usually kept in relatively small cages, but research has shown that they prefer larger and more complex environments. The physiological, neurological and health effects of standard laboratory housing are well established, but fewer studies have addressed the sustained emotional impact of a standard cage environment. One method of assessing affective states in animals is to look at the animals’ anticipatory behaviour between the presentation of a cue signalling the arrival of a reward and the arrival of that reward. The primary aim of this study was to use anticipatory behaviour to assess the affective state experienced by female rats a) reared and housed long-term in a standard laboratory cage versus a semi-naturalistic environment, and b) before and after treatment with an antidepressant or an anxiolytic. A secondary aim was to add to the literature on anticipatory behaviour by describing and comparing the frequency and duration of individual elements of anticipatory behaviour displayed by rats reared in these two systems. In all experiments, total behavioural frequency was higher in standard-housed rats compared to rats from the semi-naturalistic condition, suggesting that standard-housed rats were more sensitive to rewards and experiencing poorer welfare than rats reared in the semi-naturalistic environment. What rats did in anticipation of the reward also differed between housing treatments, with standard-housed rats mostly rearing and rats from the semi-naturalistic condition mostly sitting facing the direction of the upcoming treat. Drug interventions had no effect on the quantity or form of anticipatory behaviour, suggesting that the poorer welfare experienced by standard-housed rats was not analogous to depression or anxiety, or alternatively that the drug interventions were ineffective. This study adds to mounting evidence that standard laboratory housing for rats compromises rat welfare, and provides further scientific support for

  6. A knowledge continuity management program for the energy, infrastructure and knowledge systems center, Sandia National Laboratories.

    SciTech Connect

    Menicucci, David F.

    2006-07-01

    A growing recognition exists in companies worldwide that, when employees leave, they take with them valuable knowledge that is difficult and expensive to recreate. The concern is now particularly acute as the large ''baby boomer'' generation is reaching retirement age. A new field of science, Knowledge Continuity Management (KCM), is designed to capture and catalog the acquired knowledge and wisdom from experience of these employees before they leave. The KCM concept is in the final stages of being adopted by the Energy, Infrastructure, and Knowledge Systems Center and a program is being applied that should produce significant annual cost savings. This report discusses how the Center can use KCM to mitigate knowledge loss from employee departures, including a concise description of a proposed plan tailored to the Center's specific needs and resources.

  7. Construction of the Savannah River Ecology Laboratory Conference Center. Environmental Assessment

    SciTech Connect

    Not Available

    1993-07-01

    This Environmental Assessment (EA) reviews the environmental consequences associated with the proposed action of granting a site use permit to construct and operate a conference center on an approximately 70-acre tract of land on the Savannah River Site (SRS). While the proposed action requires an administrative decision by DOE, this EA reviews the linked action of physically constructing and operating a conference center. The SRS is a DOE-owned nuclear production facility encompassing approximately 200,000 acres in southwestern South Carolina. The proposed conference center would have an area of approximately 4,000 square feet, and would infrequently accommodate as many as 150 people, with the average being about 20 people per day. In addition to the No-Action alternative, under which the Research Foundation would not require the 70-acre tract of SRS land for a conference center, this EA considers site preservation. Under Site Preservation only minimal activities necessary to the SRS mission would occur, thereby establishing the lower limits of environmental consequences. A review conducted under the SRS permitting process identified no other forms of possible site development. Similarly, SRS areas identified in the Nuclear Complex Reconfiguration Site Proposal (DOE, 199la) do not include the conference center site area in proposed weapons complex reconfiguration activities. As a consequence, this EA does not consider other forms of possible site development as alternatives. The potential environmental consequences associated with the action of constructing and operating a conference center include impacts to cultural resources and impacts from construction activities, primarily related to land clearing (5 to 10 acres) and providing access to the site.

  8. Resin-based composite light-cured properties assessed by laboratory standards and simulated clinical conditions.

    PubMed

    Ilie, N; Bauer, H; Draenert, M; Hickel, R

    2013-01-01

    SUMMARY The following parameters were varied: 1) irradiation technique: top and bottom polymerization according to the ISO standard, and polymerization from only the top, simulating clinical situations; 2) polymerization time: 5, 10, 20, and 40 seconds; 3) storage conditions: 24 hours in distilled water, thermocycling followed by storage for four weeks in artificial saliva or alcohol. Flexural strength (FS), flexural modulus (Eflexural), indentation modulus (E), Vickers hardness (HV), and degree of conversion (DC) were measured. The laboratory results were similar to those measured by mimicking clinical conditions only at high polymerization times and mild storage conditions (20 seconds and 40 seconds and storage for 24 hours in water, and 40 seconds with aging and storing in saliva). Significantly higher DC values were measured on the top than on the bottom of a 2-mm layer for all polymerization times. Overall, 5-second and 10-second irradiation times induced significantly lower DC values compared to the currently recommended polymerization times of 20 and 40 seconds at both the top and bottom of the samples. The initial DC differences as a function of irradiation time are leveled at 24 hours of storage but seem to do well in predicting long-term material behavior. A minimum irradiation time of 20 seconds is necessary clinically to achieve the best mechanical properties with modern high-intensity light emitting diode (LED) units.

  9. A Comprehensive Subcellular Proteomic Survey of Salmonella Grown under Phagosome-Mimicking versus Standard Laboratory Conditions

    SciTech Connect

    Brown, Roslyn N.; Sanford, James A.; Park, Jea H.; Deatherage, Brooke L.; Champion, Boyd L.; Smith, Richard D.; Heffron, Fred; Adkins, Joshua N.

    2012-06-01

    Towards developing a systems-level pathobiological understanding of Salmonella enterica, we performed a subcellular proteomic analysis of this pathogen grown under standard laboratory and infection-mimicking conditions in vitro. Analysis of proteins from cytoplasmic, inner membrane, periplasmic, and outer membrane fractions yielded coverage of over 30% of the theoretical proteome. Confident subcellular location could be assigned to over 1000 proteins, with good agreement between experimentally observed location and predicted/known protein properties. Comparison of protein location under the different environmental conditions provided insight into dynamic protein localization and possible moonlighting (multiple function) activities. Notable examples of dynamic localization were the response regulators of two-component regulatory systems (e.g., ArcB, PhoQ). The DNA-binding protein Dps that is generally regarded as cytoplasmic was significantly enriched in the outer membrane for all growth conditions examined, suggestive of moonlighting activities. These observations imply the existence of unknown transport mechanisms and novel functions for a subset of Salmonella proteins. Overall, this work provides a catalog of experimentally verified subcellular protein location for Salmonella and a framework for further investigations using computational modeling.

  10. Quality assurance of CFU-GM assays: inter-laboratory variation despite standard reagents.

    PubMed

    Lumley, M A; Burton, A; Billingham, L J; McDonald, D F; Czarnecka, H M; Milligan, D W

    1999-01-01

    To investigate the hypothesis that commercial kits for CFU-GM (colony forming unit granulocyte-macrophage) assay will reduce the interlaboratory variation noted by many workers, we carried out a quality assurance exercise in 2 parts. There were 8 participants in the first study and each performed CFU-GM assays using their in-house method and a commercial kit (Stem Cell CFU Kit, Gibco) in parallel. In the second exercise there were 10 participants and each performed CFU-GM with in-house methods and with a different commercial medium (Methocult GF H4534, Stem Cell Technologies). Twelve samples of cryopreserved peripheral blood progenitor cells (PBPC) were analysed by each participant in each part of the study. A very wide range of results was found for the different in-house methods, but standardizing the clonogenic assay with the commercial kits did not reduce the variation seen. To improve the reproducibility of CFU-GM assays between laboratories, scrupulous attention should be paid to all the steps involved in the assays, as little progress will be made by using commercial medium in isolation from efforts to reduce other sources of variation.

  11. 7 CFR 91.37 - Standard hourly fee rate for laboratory testing, analysis, and other services.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... and Technology laboratory services, including issuance of certificates and personnel and overhead... processed commodity products. The new fiscal year for Science and Technology Programs commences on October 1... distribution to Science and Technology's constituents and stakeholders by the individual Laboratory...

  12. Clinical and clinical laboratory correlates in sea otters dying unexpectedly in rehabilitation centers following the Exxon Valdez oil spill.

    PubMed

    Rebar, A H; Lipscomb, T P; Harris, R K; Ballachey, B E

    1995-07-01

    Following the Exxon Valdez oil spill, 347 oiled sea otters (Enhydra lutris) were treated in rehabilitation centers. Of these, 116 died, 94 within 10 days of presentation. Clinical records of 21 otters dying during the first 10 days of rehabilitation were reviewed to define the laboratory abnormalities and clinical syndromes associated with these unexpected deaths. The most common terminal syndrome was shock characterized by hypothermia, lethargy, and often hemorrhagic diarrhea. In heavily and moderately oiled otters, shock developed within 48 hours of initial presentation, whereas in lightly oiled otters shock generally occurred during the second week of captivity. Accompanying laboratory abnormalities included leukopenia with increased numbers of immature neutrophils (degenerative left shift), lymphopenia, anemia, azotemia (primarily prerenal), hyperkalemia, hypoproteinemia/hypoalbuminemia, elevations of serum transaminases, and hypoglycemia. Shock associated with hemorrhagic diarrhea probably occurred either as a direct primary effect of oiling or as an indirect effect secondary to confinement and handling in the rehabilitation centers. Lightly oiled otters were less likely to die from shock than were heavily oiled otters (22% vs. 72%, respectively). Heavily oiled otters developed shock more rapidly and had greater numbers of laboratory abnormalities, suggesting that exposure to oil was an important contributing factor.

  13. Clinical and clinical laboratory correlates in sea otters dying unexpectedly in rehabilitation centers following the Exxon Valdez oil spill

    USGS Publications Warehouse

    Rebar, A.H.; Lipscomb, T.P.; Harris, R.K.; Ballachey, B.E.

    1995-01-01

    Following the Exxon Valdez oil spill, 347 oiled sea otters (Enhydra lutris) were treated in rehabilitation centers. Of these, 116 died, 94 within 10 days of presentation. Clinical records of 21 otters dying during the first 10 days of rehabilitation were reviewed to define the laboratory abnormalities and clinical syndromes associated with these unexpected deaths. The most common terminal syndrome was shock characterized by hypothermia, lethargy, and often hemorrhagic diarrhea. In heavily and moderately oiled otters, shock developed within 48 hours of initial presentation, whereas in lightly oiled otters shock generally occurred during the second week of captivity. Accompanying laboratory abnormalities included leukopenia with increased numbers of immature neutrophils (degenerative left shift), lymphopenia, anemia, azotemia (primarily prerenal), hyperkalemia, hypoproteinemia/hypoalbuminemia, elevations of serum transaminases, and hypoglycemia. Shock associated with hemorrhagic diarrhea probably occurred either as a direct primary effect of oiling or as an indirect effect secondary to confinement and handling in the rehabilitation centers. Lightly oiled otters were less likely to die from shock than were heavily oiled otters (22% vs. 72%, respectively). Heavily oiled otters developed shock more rapidly and had greater numbers of laboratory abnormalities, suggesting that exposure to oil was an important contributing factor.

  14. Using a Thematic Laboratory-Centered Curriculum to Teach General Chemistry

    ERIC Educational Resources Information Center

    Hopkins, Todd A.; Samide, Michael

    2013-01-01

    This article describes an approach to general chemistry that involves teaching chemical concepts in the context of two thematic laboratory modules: environmental remediation and the fate of pharmaceuticals in the environment. These modules were designed based on active-learning pedagogies and involve multiple-week projects that dictate what…

  15. The Analysis of Seawater: A Laboratory-Centered Learning Project in General Chemistry.

    ERIC Educational Resources Information Center

    Selco, Jodye I.; Roberts, Julian L., Jr.; Wacks, Daniel B.

    2003-01-01

    Describes a sea-water analysis project that introduces qualitative and quantitative analysis methods and laboratory methods such as gravimetric analysis, potentiometric titration, ion-selective electrodes, and the use of calibration curves. Uses a problem-based cooperative teaching approach. (Contains 24 references.) (YDS)

  16. 76 FR 80905 - TRICARE Evaluation of Centers for Medicare & Medicaid Services Approved Laboratory Developed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-27

    ... developed tests (LDTs), not yet examined by the United States Food and Drug Administration (FDA), to... laboratory developed tests (LDTs) if the tests are non-FDA approved, that is they have not received U.S. Food and Drug Administration (FDA) marketing 510(k) clearance or premarket approval. Under the...

  17. WASTE MINIMIZATION OPPORTUNITY ASSESSMENT: OPTICAL FABRICATION LABORATORY - FITZSIMMONS ARMY MEDICAL CENTER

    EPA Science Inventory

    Under the Waste Reduction Evaluations at Federal Sites (WREAFS) program, RREL has taken the initiative to merge the experience and resources of the EPA with other Federal agencies. At the Fitzsimmons Army Medical Center (FAMC) in Aurora, Colorado, the Army and the EPA cooperated ...

  18. The Data Acquisition and Control Systems of the Jet Noise Laboratory at the NASA Langley Research Center

    NASA Technical Reports Server (NTRS)

    Jansen, B. J., Jr.

    1998-01-01

    The features of the data acquisition and control systems of the NASA Langley Research Center's Jet Noise Laboratory are presented. The Jet Noise Laboratory is a facility that simulates realistic mixed flow turbofan jet engine nozzle exhaust systems in simulated flight. The system is capable of acquiring data for a complete take-off assessment of noise and nozzle performance. This paper describes the development of an integrated system to control and measure the behavior of model jet nozzles featuring dual independent high pressure combusting air streams with wind tunnel flow. The acquisition and control system is capable of simultaneous measurement of forces, moments, static and dynamic model pressures and temperatures, and jet noise. The design concepts for the coordination of the control computers and multiple data acquisition computers and instruments are discussed. The control system design and implementation are explained, describing the features, equipment, and the experiences of using a primarily Personal Computer based system. Areas for future development are examined.

  19. NASA Langley Research Center's Simulation-To-Flight Concept Accomplished through the Integration Laboratories of the Transport Research Facility

    NASA Technical Reports Server (NTRS)

    Martinez, Debbie; Davidson, Paul C.; Kenney, P. Sean; Hutchinson, Brian K.

    2004-01-01

    The Flight Simulation and Software Branch (FSSB) at NASA Langley Research Center (LaRC) maintains the unique national asset identified as the Transport Research Facility (TRF). The TRF is a group of facilities and integration laboratories utilized to support the LaRC's simulation-to-flight concept. This concept incorporates common software, hardware, and processes for both groundbased flight simulators and LaRC s B-757-200 flying laboratory identified as the Airborne Research Integrated Experiments System (ARIES). These assets provide Government, industry, and academia with an efficient way to develop and test new technology concepts to enhance the capacity, safety, and operational needs of the ever-changing national airspace system. The integration of the TRF enables a smooth continuous flow of the research from simulation to actual flight test.

  20. A description of the Galactic Center excess in the Minimal Supersymmetric Standard Model

    SciTech Connect

    Achterberg, Abraham; Amoroso, Simone; Caron, Sascha; Hendriks, Luc; Austri, Roberto Ruiz de

    2015-08-03

    Observations with the Fermi Large Area Telescope (LAT) indicate an excess in gamma rays originating from the center of our Galaxy. A possible explanation for this excess is the annihilation of Dark Matter particles. We have investigated the annihilation of neutralinos as Dark Matter candidates within the phenomenological Minimal Supersymmetric Standard Model (pMSSM). An iterative particle filter approach was used to search for solutions within the pMSSM. We found solutions that are consistent with astroparticle physics and collider experiments, and provide a fit to the energy spectrum of the excess. The neutralino is a Bino/Higgsino or Bino/Wino/Higgsino mixture with a mass in the range 84–92 GeV or 87–97 GeV annihilating into W bosons. A third solutions is found for a neutralino of mass 174–187 GeV annihilating into top quarks. The best solutions yield a Dark Matter relic density 0.06<Ωh{sup 2}<0.13. These pMSSM solutions make clear forecasts for LHC, direct and indirect DM detection experiments. If the pMSSM explanation of the excess seen by Fermi-LAT is correct, a DM signal might be discovered soon.

  1. Development of a Fan-Filter Unit Test Standard, LaboratoryValidations, and its Applications across Industries

    SciTech Connect

    Xu, Tengfang

    2006-10-20

    Lawrence Berkeley National Laboratory (LBNL) is now finalizing the Phase 2 Research and Demonstration Project on characterizing 2-foot x 4-foot (61-cm x 122-cm) fan-filter units in the market using the first-ever standard laboratory test method developed at LBNL.[1][2][3] Fan-filter units deliver re-circulated air and provide particle filtration control for clean environments. Much of the energy in cleanrooms (and minienvironments) is consumed by 2-foot x 4-foot (61-cm x 122-cm) or 4-foot x 4-foot (122-cm x 122-cm) fan-filter units that are typically located in the ceiling (25-100% coverage) of cleanroom controlled environments. Thanks to funding support by the California Energy Commission's Industrial Program of the Public Interest Energy Research (PIER) Program, and significant participation from manufacturers and users of fan-filter units from around the world, LBNL has developed and performed a series of standard laboratory tests and reporting on a variety of 2-foot x 4-foot (61-cm x 122-cm) fan-filter units (FFUs). Standard laboratory testing reports have been completed and reported back to anonymous individual participants in this project. To date, such reports on standard testing of FFU performance have provided rigorous and useful data for suppliers and end users to better understand, and more importantly, to quantitatively characterize performance of FFU products under a variety of operating conditions.[1] In the course of the project, the standard laboratory method previously developed at LBNL has been under continuous evaluation and update.[2][3] Based upon the updated standard, it becomes feasible for users and suppliers to characterize and evaluate energy performance of FFUs in a consistent way.

  2. Control Systems Security Center Comparison Study of Industrial Control System Standards against the Control Systems Protection Framework Cyber-Security Requirements

    SciTech Connect

    Robert P. Evans

    2005-09-01

    Cyber security standards, guidelines, and best practices for control systems are critical requirements that have been delineated and formally recognized by industry and government entities. Cyber security standards provide a common language within the industrial control system community, both national and international, to facilitate understanding of security awareness issues but, ultimately, they are intended to strengthen cyber security for control systems. This study and the preliminary findings outlined in this report are an initial attempt by the Control Systems Security Center (CSSC) Standard Awareness Team to better understand how existing and emerging industry standards, guidelines, and best practices address cyber security for industrial control systems. The Standard Awareness Team comprised subject matter experts in control systems and cyber security technologies and standards from several Department of Energy (DOE) National Laboratories, including Argonne National Laboratory, Idaho National Laboratory, Pacific Northwest National Laboratory, and Sandia National Laboratories. This study was conducted in two parts: a standard identification effort and a comparison analysis effort. During the standard identification effort, the Standard Awareness Team conducted a comprehensive open-source survey of existing control systems security standards, regulations, and guidelines in several of the critical infrastructure (CI) sectors, including the telecommunication, water, chemical, energy (electric power, petroleum and oil, natural gas), and transportation--rail sectors and sub-sectors. During the comparison analysis effort, the team compared the requirements contained in selected, identified, industry standards with the cyber security requirements in ''Cyber Security Protection Framework'', Version 0.9 (hereafter referred to as the ''Framework''). For each of the seven sector/sub-sectors listed above, one standard was selected from the list of standards identified

  3. Hyperspectral Remote Sensing and Ecological Modeling Research and Education at Mid America Remote Sensing Center (MARC): Field and Laboratory Enhancement

    NASA Technical Reports Server (NTRS)

    Cetin, Haluk

    1999-01-01

    The purpose of this project was to establish a new hyperspectral remote sensing laboratory at the Mid-America Remote sensing Center (MARC), dedicated to in situ and laboratory measurements of environmental samples and to the manipulation, analysis, and storage of remotely sensed data for environmental monitoring and research in ecological modeling using hyperspectral remote sensing at MARC, one of three research facilities of the Center of Reservoir Research at Murray State University (MSU), a Kentucky Commonwealth Center of Excellence. The equipment purchased, a FieldSpec FR portable spectroradiometer and peripherals, and ENVI hyperspectral data processing software, allowed MARC to provide hands-on experience, education, and training for the students of the Department of Geosciences in quantitative remote sensing using hyperspectral data, Geographic Information System (GIS), digital image processing (DIP), computer, geological and geophysical mapping; to provide field support to the researchers and students collecting in situ and laboratory measurements of environmental data; to create a spectral library of the cover types and to establish a World Wide Web server to provide the spectral library to other academic, state and Federal institutions. Much of the research will soon be published in scientific journals. A World Wide Web page has been created at the web site of MARC. Results of this project are grouped in two categories, education and research accomplishments. The Principal Investigator (PI) modified remote sensing and DIP courses to introduce students to ii situ field spectra and laboratory remote sensing studies for environmental monitoring in the region by using the new equipment in the courses. The PI collected in situ measurements using the spectroradiometer for the ER-2 mission to Puerto Rico project for the Moderate Resolution Imaging Spectrometer (MODIS) Airborne Simulator (MAS). Currently MARC is mapping water quality in Kentucky Lake and

  4. 75 FR 22150 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Substance Abuse and Mental Health Services Administration Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for Federal Agencies Correction In...

  5. Evolution of the NWC (Naval Weapons Center) Thermal Standard. Part 5. Summary: Thermal Standard Development and Applications.

    DTIC Science & Technology

    1984-07-01

    release; distribution unlimited. + C-) DTIFC 0 1 6 98 V. E 84 09 28 002 I. 7777 Naval Weapons Center AN ACTVITY OF THE NAVAL MATERIAL COMMAND FOREWORD...Combining these with other size considerations, a 6-inch diameter was chosen to satisfy all criteria. Materials The choice of materials used in the thermal...aluminum) shell surrounding a volume of propellant, explosive, air, or electronics. The inside material usually has a low thermal conductivity and may

  6. FAA Airworthiness Assurance NDI Validation Center (AANC) operated by Sandia National Laboratories.

    SciTech Connect

    Roach, Dennis Patrick; Hartman, Roger D.

    2010-09-01

    Airworthiness Assurance NDI Validation Center (AANC) objectives are: (1) Enhance aircraft safety and reliability; (2) Aid developing advanced aircraft designs and maintenance techniques; (3) Provide our customers with comprehensive, independent, and quantitative/qualitative evaluations of new and enhanced inspection, maintenance, and repair techniques; (4) Facilitate transferring effective technologies into the aviation industry; (5) Support FAA rulemaking process by providing guidance on content & necessary tools to meet requirements or recommendations of FARs, ADs, ACs, SBs, SSIDs, CPCP, and WFD; and (6) Coordinate with and respond to Airworthiness Assurance Working Group (AAWG) in support of FAA Aviation Rulemaking Advisory Committee (ARAC).

  7. Functions and activities of the Area Committee on Microbiology of the National Committee for Clinical Laboratory Standards.

    PubMed Central

    Washington, J A

    1991-01-01

    The Area Committee on Microbiology of the National Committee for Clinical Laboratory Standards has responsibility for the development of guidelines and standards in the field of clinical microbiology. Through the consensus process, representatives from government, industry, and professional societies have developed standards on antibacterial susceptibility testing (M2, M7, and M11), antimycobacterial susceptibility testing (M24), quality assurance on commercially prepared microbiological culture media (M22), evaluation of production lots of dehydrated Mueller-Hinton agar (M6), and preparation and testing of fetal bovine serum for use as cell culture growth supplement (M25) and guidelines on bactericidal tests (M26), protection of laboratory workers from infections transmitted by blood, body fluids, and tissue (M29), blood film examination for parasites (M15), and development of in vitro susceptibility testing criteria and quality control parameters (M23). PMID:2070343

  8. An Alternative Approach for Preparing and Standardizing Some Common Aqueous Reagents Used in an Undergraduate Laboratory

    ERIC Educational Resources Information Center

    Melaku, Samuel; Dabke, Rajeev B.

    2014-01-01

    A guide for instructors and laboratory assistants to prepare some common aqueous reagents used in an undergraduate laboratory is presented. Dilute reagents consisting of H[superscript +](aq), I[subscript 3][superscript-](aq), Ce[superscript 4+](aq), and Ag[superscript+](aq) were prepared by electrolytic oxidation of respective precursors.…

  9. 42 CFR 493.1239 - Standard: General laboratory systems quality assessment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... quality assessment. (a) The laboratory must establish and follow written policies and procedures for an... quality assessment must include a review of the effectiveness of corrective actions taken to resolve... of general laboratory systems quality assessment reviews with appropriate staff. (c) The...

  10. Retrofitting Laboratory Fume Hoods With Face Velocity Monitors at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Wagner, Ingrid E.; Bold, Margaret D.; Diamond, David B.; Kall, Phillip M.

    1997-01-01

    Extensive use and reliance on laboratory fume hoods exist at LeRC for the control of chemical hazards (nearly 175 fume hoods). Flow-measuring devices are necessary to continually monitor hood performance. The flow-measuring device should he tied into an energy management control system to detect problems at a central location without relying on the users to convey information of a problem. Compatibility concerns and limitations should always be considered when choosing the most effective flow-measuring device for a particular situation. Good practice on initial hood design and placement will provide a system for which a flow-measuring device may be used to its full potential and effectiveness.

  11. Los Alamos National Laboratory new generation standard nuclear material storage container - the SAVY4000 design

    SciTech Connect

    Stone, Timothy Amos

    2010-01-01

    Incidents involving release of nuclear materials stored in containers of convenience such as food pack cans, slip lid taped cans, paint cans, etc. has resulted in defense board concerns over the lack of prescriptive performance requirements for interim storage of nuclear materials. Los Alamos National Laboratory (LANL) has shared in these incidents and in response proactively moved into developing a performance based standard involving storage of nuclear material (RD003). This RD003 requirements document has sense been updated to reflect requirements as identified with recently issued DOE M 441.1-1 'Nuclear Material Packaging Manual'. The new packaging manual was issued at the encouragement of the Defense Nuclear Facilities Safety Board with a clear directive for protecting the worker from exposure due to loss of containment of stored materials. The Manual specifies a detailed and all inclusive approach to achieve a high level of protection; from package design & performance requirements, design life determinations of limited life components, authorized contents evaluations, and surveillance/maintenance to ensure in use package integrity over time. Materials in scope involve those stored outside an approved engineered-contamination barrier that would result in a worker exposure of in excess of 5 rem Committed Effective Does Equivalent (CEDE). Key aspects of meeting the challenge as developed around the SAVY-3000 vented storage container design will be discussed. Design performance and acceptance criteria against the manual, bounding conditions as established that the user must ensure are met to authorize contents in the package (based upon the activity of heat-source plutonium (90% Pu-238) oxide, which bounds the requirements for weapons-grade plutonium oxide), interface as a safety class system within the facility under the LANL plutonium facility DSA, design life determinations for limited life components, and a sense of design specific surveillance program

  12. Analysis of the Quality of Research and Development at the OERI Research and Development Centers and at the OERI Regional Educational Laboratories.

    ERIC Educational Resources Information Center

    Vinovskis, Maris A.

    An evaluation of the Research and Development Centers and the Regional Educational Laboratories of the Office of Educational Research and Improvement (OERI) was conducted by an outside analyst brought in in September 1991 by then Assistant Secretary Diane Ravitch. The Research and Development Centers have been one of the primary sources of…

  13. CTEPP STANDARD OPERATING PROCEDURE FOR DAY CARE CENTER SAMPLE SUBJECTS RECRUITMENT (SOP-1.11)

    EPA Science Inventory

    The CTEPP subject recruitment procedures for the daycare center component are described in the SOP. There are two stages in this phase of CTEPP subject recruitment. The objective of the first stage is to enroll daycare centers for the study. Six target counties in each state ar...

  14. Part 1: Laboratory Culture of Centroptilum triangulifer (Ephemeroptera: BAETIDAE) Using a Standardized Diet of Three Diatoms.

    EPA Science Inventory

    Development of methods for assessing exposure and effects of waterborne toxicants on stream invertebrate species is important to elucidate environmentally relevant information. United States Environmental Protection Agency (USEPA) laboratory protocols for invertebrate toxicity te...

  15. From Topos to Oikos: The Standardization of Glass Containers as Epistemic Boundaries in Modern Laboratory Research (1850-1900).

    PubMed

    Espahangizi, Kijan

    2015-09-01

    Glass vessels such as flasks and test tubes play an ambiguous role in the historiography of modern laboratory research. In spite of the strong focus on the role of materiality in the last decades, the scientific glass vessel - while being symbolically omnipresent - has remained curiously neglected in regard to its materiality. The popular image or topos of the transparent, neutral, and quasi-immaterial glass container obstructs the view of the physico-chemical functionality of this constitutive inner boundary in modern laboratory environments and its material historicity. In order to understand how glass vessels were able to provide a stable epistemic containment of spatially enclosed experimental phenomena in the new laboratory ecologies emerging in the nineteenth and early twentieth century, I will focus on the history of the material standardization of laboratory glassware. I will follow the rise of a new awareness for measurement errors due to the chemical agency of experimental glass vessels, then I will sketch the emergence of a whole techno-scientific infrastructure for the improvement of glass container quality in late nineteenth-century Germany. In the last part of my argument, I will return to the laboratory by looking at the implementation of this glass reform that created a new oikos for the inner experimental milieus of modern laboratory research.

  16. Recent Improvements to the Acoustical Testing Laboratory at the NASA Glenn Research Center

    NASA Technical Reports Server (NTRS)

    Podboy, Devin M.; Mirecki, Julius H.; Walker, Bruce E.; Sutliff, Daniel L.

    2014-01-01

    The Acoustical Testing Laboratory (ATL) consists of a 27 by 23 by 20 ft (height) convertible hemi/anechoic chamber and separate sound-attenuating test support enclosure. Absorptive fiberglass wedges in the test chamber provide an anechoic environment down to 100 Hz. A spring-isolated floor system affords vibration isolation above 3 Hz. These specifications, along with very low design background levels, enable the acquisition of accurate and repeatable acoustical measurements on test articles that produce very low sound pressures. Removable floor wedges allow the test chamber to operate in either a hemi-anechoic or anechoic configuration, depending on the size of the test article and the specific test being conducted. The test support enclosure functions as a control room during normal operations. Recently improvements were accomplished in support of continued usage of the ATL by NASA programs including an analysis of the ultra-sonic characteristics. A 3 dimensional traverse system inside the chamber was utilized for acquiring acoustic data for these tests. The traverse system drives a linear array of 13, 1/4"-microphones spaced 3" apart (36" span). An updated data acquisition system was also incorporated into the facility.

  17. Recent Improvements to the Acoustical Testing Laboratory at the NASA Glenn Research Center

    NASA Technical Reports Server (NTRS)

    Podboy, Devin M.; Mirecki, Julius H.; Walker, Bruce E.; Sutliff, Daniel L.

    2014-01-01

    The Acoustical Testing Laboratory (ATL) consists of a 27- by 23- by 20-ft (height) convertible hemi/anechoic chamber and separate sound-attenuating test support enclosure. Absorptive fiberglass wedges in the test chamber provide an anechoic environment down to 100 Hz. A spring-isolated floor system affords vibration isolation above 3 Hz. These specifications, along with very low design background levels, enable the acquisition of accurate and repeatable acoustical measurements on test articles that produce very low sound pressures. Removable floor wedges allow the test chamber to operate in either a hemi-anechoic or anechoic configuration, depending on the size of the test article and the specific test being conducted. The test support enclosure functions as a control room during normal operations. Recently improvements were accomplished in support of continued usage of the ATL by NASA programs including an analysis of the ultra-sonic characteristics. A 3-D traverse system inside the chamber was utilized for acquiring acoustic data for these tests. The traverse system drives a linear array of 13, 1/4 in.-microphones spaced 3 in. apart (36 in. span). An updated data acquisition system was also incorporated into the facility.

  18. Safety Basis Requirements for Nonnuclear Facilities at Lawrence Livermore National Laboratory Site-Specific Work Smart Standards Revision 1

    SciTech Connect

    Beach, R; Brereton, S; Failor, R; Hildum, S; Spagnolo, S; Van Warmerdam, C

    2003-02-24

    This standard establishes requirements that, when coupled with Lawrence Livermore National Laboratory's (LLNL's) Integrated Safety Management System (ISMS) methods and other Work Smart Standards for assuring worker safety, assure that the impacts of nonnuclear operations authorized in LLNL facilities are well understood and controlled in a manner that protects the health of workers, the public, and the environment. All LLNL facilities shall be classified based on potential for adverse impact of operations to the health of co-located (i.e., nearby) workers and the public in accordance with this standard, Title 10 Code of Federal Regulations (10 CFR) 830, Subpart B, and Department of Energy Order (DOE O) 420.2A. This standard provides information on: Objectives; Applicability; Safety analysis requirements; Control selection and maintenance; Documentation requirements; Safety basis review, approval, and renewal; and Safety basis implementation.

  19. Jet Propulsion Laboratory/Kennedy Space Center telerobotic inspection and manipulation demonstration

    NASA Technical Reports Server (NTRS)

    Wilcox, Brian; Davis, Leon

    1990-01-01

    The goal of this effort is to demonstrate telerobotic inspection and mainpulation of space shuttle payloads in the presence of substantial communications time delays between the operator station and the robotic work space. The processing of space shuttle payloads provides a variety of tasks which are typical of both space shuttle ground operations and Space Station in-flight operations, and communications time delays are inevitable in space operations where the operator station will be light-seconds away from the telerobot. With this demonstration we hope to show the efficacy and safety of robotic technology for ground and space operations. Our approach is to develop an experimental telerobotic system with the remote sensing, actuation and reflex portions located at KSC in Florida, while the operator control station will be located at Jet Propulsion Laboratory (JPL) in California. The JPL portion of the system includes a high-level operator interface, intelligent spatial planning and machine vision, while the KSC portion includes the robot arm, end effectors, cameras and proximity sensors, and the necessary control and communications computers and software. The communications between JPL and KSC are over a limited-bandwidth network channel (19200 baud) with unpredictable and unrepeatable time delays. In FY89 we integrated a basic version of the robotic, communications, and computer hardware, and we developed the software to perform an operator-supervised inspection of a PAM-D satellite upper stage rocket motor and its shuttle support cradle. The demonstration, though severely limited by the bulk of the available computer arm, showed the potential of telerobotics for inspection tasks. In the future, we plan to develop additional capabilities which will allow manipulation tasks to be performed, including removal of dust covers and lens caps, insertion of connectors and batteries, and installation of payload objects.

  20. Laboratory Instruments Available to Support Space Station Researchers at Marshall Space Flight Center

    NASA Technical Reports Server (NTRS)

    Panda, Binayak; Gorti, Sridhar

    2013-01-01

    A number of research instruments are available at NASA's Marshall Space Flight Center (MSFC) to support ISS researchers and their investigations. These modern analytical tools yield valuable and sometimes new informative resulting from sample characterization. Instruments include modern scanning electron microscopes equipped with field emission guns providing analytical capabilities that include angstron-level image resolution of dry, wet and biological samples. These microscopes are also equipped with silicon drift X-ray detectors (SDD) for fast yet precise analytical mapping of phases, as well as electron back-scattered diffraction (EBSD) units to map grain orientations in crystalline alloys. Sample chambers admit large samples, provide variable pressures for wet samples, and quantitative analysis software to determine phase relations. Advances in solid-state electronics have also facilitated improvements for surface chemical analysis that are successfully employed to analyze metallic materials and alloys, ceramics, slags, and organic polymers. Another analytical capability at MSFC is a mganetic sector Secondary Ion Mass Spectroscopy (SIMS) that quantitatively determines and maps light elements such as hydrogen, lithium, and boron along with their isotopes, identifies and quantifies very low level impurities even at parts per billion (ppb) levels. Still other methods available at MSFC include X-ray photo-electron spectroscopy (XPS) that can determine oxidation states of elements as well as identify polymers and measure film thicknesses on coated materials, Scanning Auger electron spectroscopy (SAM) which combines surface sensitivity, spatial lateral resolution (approximately 20 nm), and depth profiling capabilities to describe elemental compositions in near surface regions and even the chemical state of analyzed atoms. Conventional Transmission Electron Microscope (TEM) for observing internal microstructures at very high magnifications and the Electron Probe

  1. Clinical and laboratory profile of primary hyperparathyroidism in Kashmir Valley: A single-center experience

    PubMed Central

    Misgar, Raiz Ahmad; Dar, Parvez Mohiuddin; Masoodi, Shariq Rashid; Ahmad, Munir; Wani, Khursheed Alam; Wani, Arshad Iqbal; Bashir, Mir Iftikhar

    2016-01-01

    Background: Although primary hyperparathyroidism (PHPT) has become an asymptomatic disease in the West, in India, PHPT is still an uncommonly diagnosed, overtly symptomatic disease with skeletal, muscular, and renal manifestations. Aims: To describe the profile and surgical outcome of 78 consecutive PHPT patients over a period of two decades at a single center. Materials and Methods: All patients who underwent evaluation and surgery for PHPT from January 1996 to December 2015 were included. Evaluation included measurement of serum total calcium, inorganic phosphorus, alkaline phosphatase, intact parathyroid hormone, 25-hydroxy Vitamin D, 24 hour urinary calcium and radiological survey. Ultrasonography neck and technetium-99m sestamibi scan were used for preoperative localization. Results: A total of 78 patients were identified during the two decades of whom 29 patients were studied retrospectively and 49 patients prospectively. Mean age of patients was 44.72 ± 12.46, and male:female ratio was 1:6. The most common presenting features were nephrolithiasis and/or nephrocalcinosis (64.10%), bone pain (44.1%), abdominal pain (39%), constipation (26%), and myopathy (14.10%). Fractures were present only in 10.25%, and brown tumors in 6.41% patients. The cure rate in our series was 96.15%. The mean parathyroid gland weight was 2.05 ± 3.03 g. None of the 41 patients in whom long-term follow-up was available, had recurrence of PHPT. Conclusions: The profile of PHPT is changing with older age at presentation, and emergence of renal stone disease and decline in overt skeletal disease as common presentation. The parathyroid weight in our study resembles that reported from developed countries. PMID:27730083

  2. Spectral Irradiance Calibration in the Infrared 11: Comparison of (alpha) Boo and 1 Ceres with a Laboratory Standard

    NASA Technical Reports Server (NTRS)

    Witteborn, Fred C.; Cohen, Martin; Bregman, Jess D.; Wooden, Diane; Heere, Karen; Shirley, Eric L.

    1998-01-01

    Infrared spectra of two celestial objects frequently used as flux standards are calibrated against an absolute laboratory flux standard at a spectral resolving power of 100 to 200. The spectrum of the K1.5III star, alpha Boo, is measured from 3 microns to 30 microns and that of the C-type asteroid, 1 Ceres, from 5 microns to 30 microns. While these 'standard' spectra do not have the apparent precision of those based on calculated models, they do not require the assumptions involved in theoretical models of stars and asteroids. Specifically they provide a model-independent means of calibrating celestial flux in the spectral range from 12 microns to 30 microns where accurate absolute photometry is not available. The agreement found between the spectral shapes of alpha Boo and Ceres based on laboratory standards, and those based on observed ratios to alpha CMa (Sirius) and alpha Lyr (Vega), flux calibrated by theoretical modeling of these hot stars strengthens our confidence in the applicability of the stellar models as primary irradiance standards.

  3. The compliance of licensed US child care centers with national health and safety performance standards.

    PubMed Central

    Addiss, D G; Sacks, J J; Kresnow, M J; O'Neil, J; Ryan, G W

    1994-01-01

    The American Public Health Association and the American Academy of Pediatrics recently published health and safety guidelines for child care centers. A survey was conducted to determine the extent to which practices in US child care centers are reflective of these guidelines. Compliance with 16 guidelines ranged from 19.5% to 98.6%, varied considerably by state, and was not consistently associated with selected center characteristics. Prevention efforts should focus on practices for which compliance is low and on those that have the greatest disease- and injury-reducing potential. PMID:8017546

  4. Studying critical values: adverse event identification following a critical laboratory values study at the ohio state university medical center.

    PubMed

    Jenkins, James J; Mac Crawford, J; Bissell, Michael G

    2007-10-01

    No study to date has used laboratory critical values to evaluate variations in patient adverse events. We retrospectively analyzed a database of critical values to determine their distribution by hospital unit over time. The data were drawn from the Ohio State University Medical Center Information Warehouse (Columbus) for a 58-month period. Critical values were plotted over time on statistical control charts and analyzed for unusual peaks in monthly occurrence rates. Chart review of individual patient results yielded several predictor variables for the unusual peaks. Of these, occurrence of patient adverse events was the most relevant independent predictor variable for a month with an unusual number of critical values vs a normal month. This result epidemiologically confirms the basic premise of critical value reporting and suggests that the control-chart method of this type could be a new statistical tool to compare clinical activity of different hospital locations at different times.

  5. Standard testing procedures for optical fiber and unshielded twisted pair at Sandia National Laboratories. Revision

    SciTech Connect

    Adams, R.L.

    1994-09-01

    This revision updates Sandia`s working standard for testing optical fiber and unshielded twisted pair cables included in the Lab-wide telecommunications cabling infrastructure. The purpose of these standard testing procedures is to deliver to all Sandians a reliable, low-maintenance, state-of-the-art, ubiquitous telecommunications cabling infrastructure capable of satisfying all current and future telecommunication needs.

  6. Standard testing procedures for optical fiber and unshielded twisted pair at Sandia National Laboratories

    SciTech Connect

    Adams, R.L.

    1993-11-01

    This document will establish a working standard for testing optical fiber and unshielded twisted pair cables included in the Lab-wide telecommunications cabling system. The purpose of these standard testing procedures is to deliver to all Sandians a reliable, low-maintenance, state-of-the-art, ubiquitous telecommunications cabling infrastructure capable of satisfying all current and future telecommunication needs.

  7. Fitness components of Drosophila melanogaster developed on a standard laboratory diet or a typical natural food source.

    PubMed

    Kristensen, Torsten Nygaard; Henningsen, Astrid Kallestrup; Aastrup, Christian; Bech-Hansen, Mads; Bjerre, Lise B Hoberg; Carlsen, Benjamin; Hagstrup, Marie; Jensen, Sofie Graarup; Karlsen, Pernille; Kristensen, Line; Lundsgaard, Cecillie; Møller, Tine; Nielsen, Lise D; Starcke, Camilla; Sørensen, Christine Riisager; Schou, Mads Fristrup

    2016-10-01

    Drosophila melanogaster is often used as a model organism in evolutionary biology and ecophysiology to study evolutionary processes and their physiological mechanisms. Diets used to feed Drosophila cultures differ between laboratories and are often nutritious and distinct from food sources in the natural habitat. Here we rear D. melanogaster on a standard diet used in our laboratory and a field diet composed of decomposing apples collected in the field. Flies developed on these two diet compositions are tested for heat, cold, desiccation, and starvation resistance as well as developmental time, dry body mass and fat percentage. The nutritional compositions of the standard and field diets were analyzed, and discussed in relation to the phenotypic observations. Results showed marked differences in phenotype of flies from the two types of diets. Flies reared on the field diet are more starvation resistant and they are smaller, leaner, and have lower heat resistance compared to flies reared on the standard diet. Sex specific effects of diet type are observed for several of the investigated traits and the strong sexual dimorphism usually observed in desiccation resistance in D. melanogaster disappeared when rearing the flies on the field diet. Based on our results we conclude that care should be taken in extrapolating results from one type of diet to another and especially from laboratory to field diets.

  8. The World Health Organization's role and future plans in laboratory standardization.

    PubMed

    Heuck, C C

    1993-01-01

    WHO is monitoring health care and the status of health of the population in each of its member states. The statistics provides valuable information for the comparison of the effectiveness of different health systems. As part of its global responsibility on health WHO issues international reference materials (IRMs), assigns international nonproprietary names for therapeutics (INNs), publishes guidelines for good manufacturing practice (GMP) and good laboratory practice (GLP) and, in collaboration with international professional organizations, makes recommendations towards achieving global harmonization of clinical laboratory investigations.

  9. Improving Data Collection and Analysis Interface for the Data Acquisition Software of the Spin Laboratory at NASA Glenn Research Center

    NASA Technical Reports Server (NTRS)

    Abdul-Aziz, Ali; Curatolo, Ben S.; Woike, Mark R.

    2011-01-01

    In jet engines, turbines spin at high rotational speeds. The forces generated from these high speeds make the rotating components of the turbines susceptible to developing cracks that can lead to major engine failures. The current inspection technologies only allow periodic examinations to check for cracks and other anomalies due to the requirements involved, which often necessitate entire engine disassembly. Also, many of these technologies cannot detect cracks that are below the surface or closed when the crack is at rest. Therefore, to overcome these limitations, efforts at NASA Glenn Research Center are underway to develop techniques and algorithms to detect cracks in rotating engine components. As a part of these activities, a high-precision spin laboratory is being utilized to expand and conduct highly specialized tests to develop methodologies that can assist in detecting predetermined cracks in a rotating turbine engine rotor. This paper discusses the various features involved in the ongoing testing at the spin laboratory and elaborates on its functionality and on the supporting data system tools needed to enable successfully running optimal tests and collecting accurate results. The data acquisition system and the associated software were updated and customized to adapt to the changes implemented on the test rig system and to accommodate the data produced by various sensor technologies. Discussion and presentation of these updates and the new attributes implemented are herein reported

  10. Purgeable organic compounds at or near the Idaho Nuclear Technology and Engineering Center, Idaho National Laboratory, Idaho, 2015

    USGS Publications Warehouse

    Maimer, Neil V.; Bartholomay, Roy C.

    2016-05-25

    During 2015, the U.S. Geological Survey, in cooperation with the U.S. Department of Energy, collected groundwater samples from 31 wells at or near the Idaho Nuclear Technology and Engineering Center (INTEC) at the Idaho National Laboratory for purgeable organic compounds (POCs). The samples were collected and analyzed for the purpose of evaluating whether purge water from wells located inside an areal polygon established downgradient of the INTEC must be treated as a Resource Conservation and Recovery Act listed waste.POC concentrations in water samples from 29 of 31 wells completed in the eastern Snake River Plain aquifer were greater than their detection limit, determined from detection and quantitation calculation software, for at least one to four POCs. Of the 29 wells with concentrations greater than their detection limits, only 20 had concentrations greater than the laboratory reporting limit as calculated with detection and quantitation calculation software. None of the concentrations exceeded any maximum contaminant levels established for public drinking water supplies. Most commonly detected compounds were 1,1,1-trichoroethane, 1,1-dichloroethene, and trichloroethene.

  11. Acoustic emissions verification testing of International Space Station experiment racks at the NASA Glenn Research Center Acoustical Testing Laboratory

    NASA Astrophysics Data System (ADS)

    Akers, James C.; Passe, Paul J.; Cooper, Beth A.

    2005-09-01

    The Acoustical Testing Laboratory (ATL) at the NASA John H. Glenn Research Center (GRC) in Cleveland, OH, provides acoustic emission testing and noise control engineering services for a variety of specialized customers, particularly developers of equipment and science experiments manifested for NASA's manned space missions. The ATL's primary customer has been the Fluids and Combustion Facility (FCF), a multirack microgravity research facility being developed at GRC for the USA Laboratory Module of the International Space Station (ISS). Since opening in September 2000, ATL has conducted acoustic emission testing of components, subassemblies, and partially populated FCF engineering model racks. The culmination of this effort has been the acoustic emission verification tests on the FCF Combustion Integrated Rack (CIR) and Fluids Integrated Rack (FIR), employing a procedure that incorporates ISO 11201 (``Acoustics-Noise emitted by machinery and equipment-Measurement of emission sound pressure levels at a work station and at other specified positions-Engineering method in an essentially free field over a reflecting plane''). This paper will provide an overview of the test methodology, software, and hardware developed to perform the acoustic emission verification tests on the CIR and FIR flight racks and lessons learned from these tests.

  12. NASA Johnson Space Center's Planetary Sample Analysis and Mission Science (PSAMS) Laboratory: A National Facility for Planetary Research

    NASA Technical Reports Server (NTRS)

    Draper, D. S.

    2016-01-01

    NASA Johnson Space Center's (JSC's) Astromaterials Research and Exploration Science (ARES) Division, part of the Exploration Integration and Science Directorate, houses a unique combination of laboratories and other assets for conducting cutting edge planetary research. These facilities have been accessed for decades by outside scientists, most at no cost and on an informal basis. ARES has thus provided substantial leverage to many past and ongoing science projects at the national and international level. Here we propose to formalize that support via an ARES/JSC Plane-tary Sample Analysis and Mission Science Laboratory (PSAMS Lab). We maintain three major research capa-bilities: astromaterial sample analysis, planetary process simulation, and robotic-mission analog research. ARES scientists also support planning for eventual human ex-ploration missions, including astronaut geological training. We outline our facility's capabilities and its potential service to the community at large which, taken together with longstanding ARES experience and expertise in curation and in applied mission science, enable multi-disciplinary planetary research possible at no other institution. Comprehensive campaigns incorporating sample data, experimental constraints, and mission science data can be conducted under one roof.

  13. 75 FR 34452 - Center for Drug Evaluation and Research Data Standards Plan; Availability for Comment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-17

    ... possible. Facilitating improvements requires careful analysis, advanced planning, project management... developed to ensure successful use of those standardized data, and a set of recommended projects to begin...

  14. Implementation of the OECD principles of good laboratory practice in test facilities complying with a quality system accredited to the ISO/IEC 17025 standard.

    PubMed

    Feller, Etty

    2008-01-01

    Laboratories with a quality system accredited to the ISO/IEC 17025 standard have a definite advantage, compared to non-accredited laboratories, when preparing their facilities for the implementation of the principles of good laboratory practice (GLP) of the Organisation for Economic Co-operation and Development (OECD). Accredited laboratories have an established quality system covering the administrative and technical issues specified in the standard. The similarities and differences between the ISO/IEC 17025 standard and the OECD principles of GLP are compared and discussed.

  15. Knowledge and practices of laboratory workers on standardized antimicrobial susceptibility testing and biosafety practices to prevent the spread of superbugs in Pakistan.

    PubMed

    Ghanchi, Najia K; Khan, Erum; Farooqi, Joveria Q; Fasih, Naima; Dojki, Maqboola; Hughes, Molly A

    2014-09-01

    A cross-sectional survey using structured questionnaire was conducted to assess practices of microbiological laboratories working with pathogens. Forty-eight laboratory workers (50%) agreed that laboratory methods to detect antimicrobial resistance are not standardized in Pakistan, and 6% of the laboratory workers were not aware of the standardization of antimicrobial susceptibility testing in Pakistan. Reported rates of awareness regarding the role of waste disposal, disinfection, and handwashing in limiting the spread of antimicrobial resistance were 75%, 42%, and 81%, respectively. Our results provide baseline data for planning programs to train, supervise, and improve the operational quality of microbiological laboratories nationwide to prevent the spread of superbugs.

  16. [Control of accuracy of immunoserological laboratory data on medical network and standardization].

    PubMed

    Konishi, Keiko

    2003-05-01

    Construction of a medical network for each region and organization has become possible by utilization of information technology. Standardization of the data on the medical network is urgent. Especially, the standardization of immunoserological data is much delayed. In this study, the possibility of standardization of such data was reconsidered based on the findings from various control surveys. Regarding the measurement items for serum concentrations of proteins and other compounds, we concluded that standardization should occur in a manner similar to the method for standardization of biochemical data and accurate control. The data on CRP, IgG, IgA, IgM and AFP, which are determined using the respective standard compound, were converged to a range with inter-facility differences of less than 10% CV. The data on CEA were also converged to achieve an inter-facility difference of less than 10% CV through repeated survey. Automatic measurement for the markers of infection diseases has progressed, and the expression of measurements was changed to the absolute value of COI, U/ml or IU/ml although it was titer in the past. Since these expressions now coexist, it is impossible to standardize the data with absolute qualitative values. It seemed necessary to present them uniformly with qualitative or clinical criteria values or express the presence or absence of infection by a combination of related markers. The measurements obtained from autoantibody-related tests using identical reagent were found coincident, but measurements obtained using different reagents were discrepant and the differences were greater than the sensitivity of measurement. In immunoserological testing and immunochemical testing, it is most important whether the antigen/antibody used as the reagent is the same preparation or not. Therefore, the test should be reconsidered through setting a certain restrictions on each recognition site of epitope and antibody. Thus, we concluded that use of a suitable

  17. Allied Health Occupations II. Medical Laboratory Assistant Component. Student Learning Guide. Middletown Public Schools Curriculum Standards.

    ERIC Educational Resources Information Center

    Middletown Public Schools, CT.

    This volume outlines the requirements and content of a second-year course in allied health occupations education that is intended to provide students with a practical understanding of the work done by medical laboratory technicians and technologists. Addressed in the individual units of the course are the following topics: the value of…

  18. Implementation of ISO guide 25 in a medical dosimetry secondary standards calibration laboratory

    SciTech Connect

    DeWerd, L.A.

    1995-12-31

    Currently, there is a great deal of discussion among industry and government agencies about ISO 9000 accreditation. U.S. manufacturers with ISO 9000 accreditation are regarded more favorably by European countries. The principles behind the ISO 9000 accreditation are based on the Total Quality Management (TQM) principles that are being implemented in many U.S. industries. This paper will deal only with the calibration issue. There is a difference in the areas covered by ISO 9000 and ISO Guide 25 documents. ISO 9000, in particular ISO 9001 - ISO 9003, cover the {open_quotes}calibration{close_quotes} of inspection, measuring and test equipment. This equipment is basically used for {open_quotes}factory calibrations{close_quotes} to determine that equipment is performing within manufacturer specifications. ISO Guide 25 is specifically for {open_quotes}calibration and testing laboratories,{close_quotes} generally laboratories that have painstaking procedures to reduce uncertainties and establish high accuracy of the transfer of calibration. The experience of the University of Wisconsin Accredited Dosimetry Calibration Laboratory in conforming to ISO Guide 25 will be outlined. The entire laboratory staff must become familiar with the process and an individual with direct authority must become the one to maintain the quality of equipment and calibrations in the role of {open_quotes}quality-assurance manager.{close_quotes}

  19. Estimation of Wildlife Hazard Levels Using Interspecies Correlation Models and Standard Laboratory Rodent Toxicity Data

    EPA Science Inventory

    Toxicity data from laboratory rodents are widely available and frequently used in human health assessments as an animal model. We explore the possibility of using single rodent acute toxicity values to predict chemical toxicity to a diversity of wildlife species and to estimate ...

  20. Cellular Cultivation: Growing HeLa Cells Using Standard High School Laboratory Equipment.

    ERIC Educational Resources Information Center

    Woloschak, Gayle; And Others

    1995-01-01

    Describes experiments to culture cells in a laboratory that provide students with hands-on experience in manipulating cells and a chance to observe cell growth characteristics first hand. Exposes students to sterile technique, cell culture, cell growth concepts, and eukaryotic cell structure. (JRH)

  1. The impact of standard preparation practice on the runoff and soil erosion rates under laboratory conditions

    NASA Astrophysics Data System (ADS)

    Khaledi Darvishan, Abdulvahed; Homayounfar, Vafa; Hamidreza Sadeghi, Seyed

    2016-09-01

    The use of laboratory methods in soil erosion studies, rainfall simulation experiments, Gerlach troughs, and other measurements such as ring infiltrometer has been recently considered more and more because of many advantages in controlling rainfall properties and high accuracy of sampling and measurements. However, different stages of soil removal, transfer, preparation and placement in laboratory plots cause significant changes in soil structure and, subsequently, the results of runoff, sediment concentration and soil loss. Knowing the rate of changes in sediment concentration and soil loss variables with respect to the soil preparation for laboratory studies is therefore inevitable to generalize the laboratory results to field conditions. However, there has been little attention given to evaluate the effects of soil preparation on sediment variables. The present study was therefore conducted to compare sediment concentration and soil loss in natural and prepared soil. To achieve the study purposes, 18 field 1 × 1 m plots were adopted in an 18 % gradient slope with sandy-clay-loam soil in the Kojour watershed, northern Iran. A portable rainfall simulator was then used to simulate rainfall events using one or two nozzles of BEX: 3/8 S24W for various rainfall intensities with a constant height of 3 m above the soil surface. Three rainfall intensities of 40, 60 and 80 mm h-1 were simulated on both prepared and natural soil treatments with three replications. The sediment concentration and soil loss at five 3 min intervals after time to runoff were then measured. The results showed the significant increasing effects of soil preparation (p ≤ 0.01) on the average sediment concentration and soil loss. The increasing rates of runoff coefficient, sediment concentration and soil loss due to the study soil preparation method for laboratory soil erosion plots were 179, 183 and 1050 % (2.79, 2.83 and 11.50 times), respectively.

  2. 75 FR 56549 - National Center for Health Statistics (NCHS), Classifications and Public Health Data Standards...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-16

    ...), Classifications and Public Health Data Standards Staff, Announces the Following Meeting Name: ICD-9-CM... Administrator, Classifications and Public Health Data Standards Staff, NCHS, 3311 Toledo Road, Room 2337... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH...

  3. 75 FR 39265 - National Center for Health Statistics (NCHS), Classifications and Public Health Data Standards...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-08

    ...), Classifications and Public Health Data Standards Staff, Announces the Following Meeting Name: ICD-9-CM... for Disease Control and Prevention, Classifications and Public Health Data Standards, 3311 Toledo Road... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH...

  4. 78 FR 53148 - National Center for Health Statistics (NCHS), Classifications and Public Health Data Standards...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-28

    ...), Classifications and Public Health Data Standards Staff, Announces the Following Meeting Name: ICD-9-CM..., Medical Systems Administrator, Classifications and Public Health Data Standards Staff, NCHS, 3311 Toledo... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH...

  5. 40 CFR 79.60 - Good laboratory practices (GLP) standards for inhalation exposure health effects testing.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., scientific or academic establishment, government agency, or organizational unit thereof, and any other legal... for monitoring each study to assure management that the facilities, equipment, personnel, methods... describes the methods and standard operating procedures, and that the reported results accurately...

  6. 40 CFR 79.60 - Good laboratory practices (GLP) standards for inhalation exposure health effects testing.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., scientific or academic establishment, government agency, or organizational unit thereof, and any other legal... for monitoring each study to assure management that the facilities, equipment, personnel, methods... describes the methods and standard operating procedures, and that the reported results accurately...

  7. 40 CFR 79.60 - Good laboratory practices (GLP) standards for inhalation exposure health effects testing.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., scientific or academic establishment, government agency, or organizational unit thereof, and any other legal... for monitoring each study to assure management that the facilities, equipment, personnel, methods... describes the methods and standard operating procedures, and that the reported results accurately...

  8. Virtual Global Transplant Laboratory Standard Operating Protocol for Donor Alloantigen-specific Interferon-gamma ELISPOT Assay

    PubMed Central

    Carroll, Robert; Troelnikov, Alexander; Chong, Anita S.

    2016-01-01

    Abstract The quantification of frequency of IFN-γ–producing T cells responding to donor alloantigen using the IFN-γ enzyme linked immunosorbent spot (ELISPOT) holds potential for pretransplant and posttransplant immunological risk stratification. The effectiveness of this assay, and the ability to compare results generated by different studies, is dependent on the utilization of a standardized operating procedure (SOP). Key factors in assay standardization include the identification of primary and secondary antibody pairs, and the reading of the ELISPOT plate with a standardized automated algorithm. Here, we describe in detail, an SOP that should provide low coefficient of variation results. For multicenter trials, it is recommended that groups perform the ELISPOT assays locally but use a centralized ELISPOT reading facility, as this has been shown to be beneficial in reducing coefficient of variation between laboratories even when the SOP is strictly adhered to. PMID:27826604

  9. The NBS/NRL (National Bureau of Standards/Naval Research Laboratory) Free Electron Laser Facility,

    DTIC Science & Technology

    1987-01-01

    343eec... .. ba as a joint project with the Naval Research Laboratory. Theelectron beam source is the i35-MeV CW racetrack microtron (RTM) presently...materials sciences, and basic physics and chemistry. The driving accelerator is a 185-MeV CW racetrack microtron (RTM) now nearing completion. *This...JV Accelerator The electron accelerator of the NBS/NRL FEL facility is the NBS/Los Alamos Racetrack Microtron (RTM). A general description of the RTM

  10. OVERVIEW OF THE COOPERATION BETWEEN THE CHERNOBYL CENTER'S INTERNATIONAL RADIOECOLOGY LABORATORY IN SLAVUTYCH, UKRAINE AND U.S. RESEARCH CENTERS BETWEEN 2000-2010

    SciTech Connect

    Farfan, E.; Jannik, T.

    2011-10-01

    The International Radioecology Laboratory (IRL) located in Slavutych, Ukraine was created in 1999 under the initiative of the United States Government and the Government of Ukraine in the framework of international cooperation on evaluation and minimization of consequences of the Chernobyl nuclear power plant (ChNPP) accident. Since the time the IRL was founded, it has participated in a large number of projects, including the following: (1) study of radionuclide accumulation, distribution, and migration in components of various ecological systems of the Chernobyl Exclusion Zone (ChEZ); (2) radiation dose assessments; (3) study of the effects of radiation influence on biological systems; (4) expert analysis of isotopic and quantitative composition of radioactive contaminants; (5) development of new methods and technologies intended for radioecological research; (6) evaluation of future developments and pathways for potential remediation of the ChEZ areas; (7) assistance in provision of physical protection systems for ionizing irradiation sources at Ukrainian enterprises; (8) reviews of open Russian language publications on issues associated with consequences of the ChNPP accident, radioactive waste management, radioecological monitoring, and ChNPP decommissioning; (9) conduct of training courses on problems of radioecology, radiation safety, radioecological characterization of test sites and environmental media, and on research methods; (10) conduct of on-site scientific conferences and workshops on the ChEZ and radioecology problems; participation in off-site scientific conferences and meetings; and (11) preparation of scientific and popular science publications, and interactions with mass media representatives. This article provides a brief overview of the major achievements resulting from this cooperation between the IRL and U.S. research centers.

  11. Overview of the cooperation between the Chernobyl Center's International Radioecology Laboratory in Slavutych, Ukraine, and U.S. research centers between 2000 and 2010.

    PubMed

    Bondarkov, Mikhail D; Gaschak, Sergey P; Oskolkov, Boris Ya; Maksimenko, Andrey M; Farfán, Eduardo B; Jannik, G Timothy; Labone, Elizabeth D

    2011-10-01

    The International Radioecology Laboratory (IRL) located in Slavutych, Ukraine, was created in 1999 under the initiative of the United States Government and the Government of Ukraine in the framework of international cooperation on evaluation and minimization of consequences of the Chernobyl nuclear power plant (ChNPP) accident. Since the time the IRL was founded, it has participated in a large number of projects, including the following: 1) study of radionuclide accumulation, distribution, and migration in components of various ecological systems of the Chernobyl Exclusion Zone (ChEZ); 2) radiation dose assessments; 3) study of the effects of radiation influence on biological systems; 4) expert analysis of isotopic and quantitative composition of radioactive contaminants; 5) development of new methods and technologies intended for radioecological research; 6) evaluation of future developments and pathways for potential remediation of the ChEZ areas; 7) assistance in provision of physical protection systems for ionizing irradiation sources at Ukrainian enterprises; 8) reviews of open Russian language publications on issues associated with consequences of the ChNPP accident, radioactive waste management, radioecological monitoring, and ChNPP decommissioning; 9) conduct of training courses on problems of radioecology, radiation safety, radioecological characterization of test sites and environmental media, and research methods; 10) conduct of on-site scientific conferences and workshops on the ChEZ and radioecology problems; participation in off-site scientific conferences and meetings; and 11) preparation of scientific and popular science publications and interactions with mass media representatives. This article provides a brief overview of the major achievements resulting from this cooperation between the IRL and U.S. research centers.

  12. Measuring Malaysia School Resource Centers' Standards through iQ-PSS: An Online Management Information System

    ERIC Educational Resources Information Center

    Zainudin, Fadzliaton; Ismail, Kamarulzaman

    2010-01-01

    The Ministry of Education has come up with an innovative way to monitor the progress of 9,843 School Resource Centers (SRCs) using an online management information system called iQ-PSS (Quality Index of SRC). This paper aims to describe the data collection method and analyze the current state of SRCs in Malaysia and explain how the results can be…

  13. How do laboratory technicians perceive their role in the tuberculosis diagnostic process? A cross-sectional study among laboratory technicians in health centers of Central Java Province, Indonesia

    PubMed Central

    Widjanarko, Bagoes; Widyastari, Dyah Anantalia; Martini, Martini; Ginandjar, Praba

    2016-01-01

    Purpose Detection of acid-fast bacilli in respiratory specimens serves as an initial pulmonary tuberculosis (TB) diagnosis. Laboratories are the essential and fundamental part of all health systems. This study aimed to describe how laboratory technicians perceived their own self and work. This included perceived self-efficacy, perceived role, perceived equipment availability, perceived procedures, perceived reward and job, and perceived benefit of health education, as well as level of knowledge and attitudes related to work performance of laboratory technicians. Methods This was a cross-sectional quantitative study involving 120 laboratory technicians conducted in Central Java. Interviews and observation were conducted to measure performance and work-related variables. Results Among 120 laboratory technicians, 43.3% showed fairly good performance. They complied with 50%–75% of all procedures, including sputum collection, laboratory tools utilization, sputum smearing, staining, smear examination, grading of results, and universal precaution practice. Perceived role, perceived self-efficacy, and knowledge of laboratory procedures were significantly correlated to performance, besides education and years of working as a laboratory technician. Perceived equipment availability was also significantly correlated to performance after the education variable was controlled. Conclusion Most of the laboratory technicians believed that they have an important role in TB patients’ treatment and should display proper self-efficacy in performing laboratory activities. The result may serve as a basic consideration to develop a policy for enhancing motivation of laboratory technicians in order to improve the TB control program. PMID:27660502

  14. Comparison of a new cobinamide-based method to a standard laboratory method for measuring cyanide in human blood.

    PubMed

    Swezey, Robert; Shinn, Walter; Green, Carol; Drover, David R; Hammer, Gregory B; Schulman, Scott R; Zajicek, Anne; Jett, David A; Boss, Gerry R

    2013-01-01

    Most hospital laboratories do not measure blood cyanide concentrations, and samples must be sent to reference laboratories. A simple method is needed for measuring cyanide in hospitals. The authors previously developed a method to quantify cyanide based on the high binding affinity of the vitamin B12 analog, cobinamide, for cyanide and a major spectral change observed for cyanide-bound cobinamide. This method is now validated in human blood, and the findings include a mean inter-assay accuracy of 99.1%, precision of 8.75% and a lower limit of quantification of 3.27 µM cyanide. The method was applied to blood samples from children treated with sodium nitroprusside and it yielded measurable results in 88 of 172 samples (51%), whereas the reference laboratory yielded results in only 19 samples (11%). In all 19 samples, the cobinamide-based method also yielded measurable results. The two methods showed reasonable agreement when analyzed by linear regression, but not when analyzed by a standard error of the estimate or paired t-test. Differences in results between the two methods may be because samples were assayed at different times on different sample types. The cobinamide-based method is applicable to human blood, and can be used in hospital laboratories and emergency rooms.

  15. 40 CFR 79.60 - Good laboratory practices (GLP) standards for inhalation exposure health effects testing.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) Mixtures of test emissions or reference solutions with carriers. (i) For test emissions or each reference... specified: Batch means a specific quantity or lot of a test fuel, additive/base fuel mixture, or reference... chemical substance or mixture, analytical standard, or material other than engine/motor vehicle...

  16. Leishmania infection: laboratory diagnosing in the absence of a "gold standard".

    PubMed

    Rodríguez-Cortés, Alhelí; Ojeda, Ana; Francino, Olga; López-Fuertes, Laura; Timón, Marcos; Alberola, Jordi

    2010-02-01

    There is no gold standard for diagnosing leishmaniases. Our aim was to assess the operative validity of tests used in detecting Leishmania infection using samples from experimental infections, a reliable equivalent to the classic definition of gold standard. Without statistical differences, the highest sensitivity was achieved by protein A (ProtA), immunoglobulin (Ig)G2, indirect fluorescenece antibody test (IFAT), lymphocyte proliferation assay, quantitative real-time polymerase chain reaction of bone marrow (qPCR-BM), qPCR-Blood, and IgG; and the highest specificity by IgG1, IgM, IgA, qPCR-Blood, IgG, IgG2, and qPCR-BM. Maximum positive predictive value was obtained simultaneously by IgG2, qPCR-Blood, and IgG; and maximum negative predictive value by qPCR-BM. Best positive and negative likelihood ratios were obtained by IgG2. The test having the greatest, statistically significant, area under the receiver operating characteristics curve was IgG2 enzyme-linked immunosorbent assay (ELISA). Thus, according to the gold standard used, IFAT and qPCR are far from fulfilling the requirements to be considered gold standards, and the test showing the highest potential to detect Leishmania infection is Leishmania-specific ELISA IgG2.

  17. 76 FR 72216 - Occupational Exposure to Hazardous Chemicals in Laboratories Standard; Extension of the Office of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-22

    ... Request (ICR). All comments including any personal information you provide, are placed in the public... 1910, Subpart Z. They do so by developing a written Chemical Hygiene Plan (CHP) that describes standard... commenters about submitting personal information, such as social security numbers and dates of...

  18. 76 FR 25376 - Occupational Exposure to Hazardous Chemicals in Laboratories Standard; Extension of the Office of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-04

    ...-0059) for the Information Collection Request (ICR). All comments, including any personal information... by developing a written Chemical Hygiene Plan (CHP) that describes: Standard operating procedures for... commenters about submitting personal information such as Social Security Numbers and date of birth....

  19. 78 FR 63999 - Notice of Vitamin D Standardization Program (VDSP) Symposium: Tools To Improve Laboratory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-25

    ... the detection, evaluation, and treatment of vitamin D deficiency and insufficiency by making... HUMAN SERVICES National Institutes of Health Notice of Vitamin D Standardization Program (VDSP... one-day symposium on November 14, 2013, to present information about the Vitamin D...

  20. Isolation gowns in health care settings: Laboratory studies, regulations and standards, and potential barriers of gown selection and use

    PubMed Central

    Kilinc Balci, F. Selcen

    2016-01-01

    Although they play an important role in infection prevention and control, textile materials and personal protective equipment (PPE) used in health care settings are known to be one of the sources of cross-infection. Gowns are recommended to prevent transmission of infectious diseases in certain settings; however, laboratory and field studies have produced mixed results of their efficacy. PPE used in health care is regulated as either class I (low risk) or class II (intermediate risk) devices in the United States. Many organizations have published guidelines for the use of PPE, including isolation gowns, in health care settings. In addition, the Association for the Advancement of Medical Instrumentation published a guidance document on the selection of gowns and a classification standard on liquid barrier performance for both surgical and isolation gowns. However, there is currently no existing standard specific to isolation gowns that considers not only the barrier resistance but also a wide array of end user desired attributes. As a result, infection preventionists and purchasing agents face several difficulties in the selection process, and end users have limited or no information on the levels of protection provided by isolation gowns. Lack of knowledge about the performance of protective clothing used in health care became more apparent during the 2014 Ebola epidemic. This article reviews laboratory studies, regulations, guidelines and standards pertaining to isolation gowns, characterization problems, and other potential barriers of isolation gown selection and use. PMID:26391468

  1. Tu-144LL SST Flying Laboratory Landing on Runway at Zhukovsky Air Development Center near Moscow, Ru

    NASA Technical Reports Server (NTRS)

    1998-01-01

    The Tupolev Tu-144LL SST Flying Laboratory rolls down the runway at the Zhukovsky Air Development Center near Moscow, Russia, after a 1998 test flight. NASA teamed with American and Russian aerospace industries for an extended period in a joint international research program featuring the Russian-built Tu-144LL supersonic aircraft. The object of the program was to develop technologies for a proposed future second-generation supersonic airliner to be developed in the 21st Century. The aircraft's initial flight phase began in June 1996 and concluded in February 1998 after 19 research flights. A shorter follow-on program involving seven flights began in September 1998 and concluded in April 1999. All flights were conducted in Russia from Tupolev's facility at the Zhukovsky Air Development Center near Moscow. The centerpiece of the research program was the Tu 144LL, a first-generation Russian supersonic jetliner that was modified by its developer/builder, Tupolev ANTK (aviatsionnyy nauchno-tekhnicheskiy kompleks-roughly, aviation technical complex), into a flying laboratory for supersonic research. Using the Tu-144LL to conduct flight research experiments, researchers compared full-scale supersonic aircraft flight data with results from models in wind tunnels, computer-aided techniques, and other flight tests. The experiments provided unique aerodynamic, structures, acoustics, and operating environment data on supersonic passenger aircraft. Data collected from the research program was being used to develop the technology base for a proposed future American-built supersonic jetliner. Although actual development of such an advanced supersonic transport (SST) is currently on hold, commercial aviation experts estimate that a market for up to 500 such aircraft could develop by the third decade of the 21st Century. The Tu-144LL used in the NASA-sponsored research program was a 'D' model with different engines than were used in production-model aircraft. Fifty experiments

  2. Intercomparison of a range of primary gas standards of carbon monoxide in nitrogen and carbon dioxide in nitrogen prepared by the National Institute of Standards and Technology and the National Physical Laboratory

    SciTech Connect

    Hughes, E.E.; Zielinski, W.L. Jr. ); Davenport, A.J.; Woods, P.T. )

    1991-04-01

    Measurements were carried out by the National Physical Laboratory (NPL) in the United Kingdom and the National Institute of Standards and Technology (NIST) in the US to intercompare the primary gravimetric gas standards developed by these two laboratories. These intercomparisons involved analyses of a set of CO and CO{sub 2} NIST Standard Reference Materials by the NPL, and of a similar set of NPL primary standards by the NIST. In each case, the exact concentrations of the exchanged sets were unknown to the analyzing laboratory. The CO and CO{sub 2} standards ranged in nominal concentration from 8% to 10 ppm and from 8% to 0.5%, respectively. The analyses were carried out using primary gravimetric standards, which were independently produced by the two laboratories. The mean difference between the values assigned by the supplying laboratory and the values determined by the analyzing laboratory was less than 0.2% relative for both sets of CO and CO{sub 2} standards. The results confirmed that standards produced by NPL and NIST have a degree of consistency, and that measurements obtained using these standards for measurements of levels of atmospheric CO and CO{sub 2} may be directly intercompared.

  3. Overview of groundwater and surface water standards pertinent to the Idaho National Engineering Laboratory. Revision 3

    SciTech Connect

    Lundahl, A.L.; Williams, S.; Grizzle, B.J.

    1995-09-01

    This document presents an overview of groundwater- and surface water-related laws, regulations, agreements, guidance documents, Executive Orders, and DOE orders pertinent to the Idaho National Engineering Laboratory. This document is a summary and is intended to help readers understand which regulatory requirements may apply to their particular circumstances. However, the document is not intended to be used in lieu of applicable regulations. Unless otherwise noted, the information in this report reflects a summary and evaluation completed July 1, 1995. This document is considered a Living Document, and updates on changing laws and regulations will be provided.

  4. Rapid identification of bacteria and yeast: summary of a National Committee for Clinical Laboratory Standards proposed guideline.

    PubMed

    Baron, E J

    2001-07-15

    Using colony morphology on selected agars, Gram-stain morphology, and a number of 1-step biochemical or enzymatic tests, skilled microbiologists can identify the species of the majority of isolates seen routinely in a clinical laboratory. These results are often available more quickly than and are as accurate as those derived from conventional methods. The National Committee for Clinical Laboratory Standards has produced a guideline that describes tests that can be used to identify a number of aerobic gram-negative rods and gram-positive cocci, a number of commonly isolated anaerobes, and 3 species of yeast. An overview of the organisms included in the guideline, the tests that identify them, and the situations in which rapid testing is appropriate is presented here.

  5. Advanced Stirling Convertor Dual Convertor Controller Testing at NASA Glenn Research Center in the Radioisotope Power Systems System Integration Laboratory

    NASA Technical Reports Server (NTRS)

    Dugala, Gina M.; Taylor, Linda M.; Bell, Mark E.; Dolce, James L.; Fraeman, Martin; Frankford, David P.

    2015-01-01

    NASA Glenn Research Center developed a nonnuclear representation of a Radioisotope Power System (RPS) consisting of a pair of Advanced Stirling Convertors (ASCs), Dual Convertor Controller (DCC) EMs (engineering models) 2 and 3, and associated support equipment, which were tested in the Radioisotope Power Systems System Integration Laboratory (RSIL). The DCC was designed by the Johns Hopkins University Applied Physics Laboratory (JHU/APL) to actively control a pair of ASCs. The first phase of testing included a Dual Advanced Stirling Convertor Simulator (DASCS), which was developed by JHU/APL and simulates the operation and electrical behavior of a pair of ASCs in real time via a combination of hardware and software. RSIL provides insight into the electrical interactions between a representative radioisotope power generator, its associated control schemes, and realistic electric system loads. The first phase of integration testing included the following spacecraft bus configurations: capacitive, battery, and super-capacitor. A load profile, created based on data from several missions, tested the RPS's and RSIL's ability to maintain operation during load demands above and below the power provided by the RPS. The integration testing also confirmed the DCC's ability to disconnect from the spacecraft when the bus voltage dipped below 22 volts or exceeded 36 volts. Once operation was verified with the DASCS, the tests were repeated with actual operating ASCs. The goal of this integration testing was to verify operation of the DCC when connected to a spacecraft and to verify the functionality of the newly designed RSIL. The results of these tests are presented in this paper.

  6. Advanced Stirling Convertor Dual Convertor Controller Testing at NASA Glenn Research Center in the Radioisotope Power Systems System Integration Laboratory

    NASA Technical Reports Server (NTRS)

    Dugala, Gina M.; Taylor, Linda M.; Bell, Mark E.; Dolce, James L.; Fraeman, Martin; Frankford, David P.

    2015-01-01

    NASA Glenn Research Center (GRC) developed a non-nuclear representation of a Radioisotope Power System (RPS) consisting of a pair of Advanced Stirling Convertors (ASC), a Dual Convertor Controller (DCC) EM (engineering model) 2 & 3, and associated support equipment, which were tested in the Radioisotope Power Systems System Integration Laboratory (RSIL). The DCC was designed by the Johns Hopkins University/Applied Physics Laboratory (JHU/APL) to actively control a pair of Advanced Stirling Convertors (ASC). The first phase of testing included a Dual Advanced Stirling Convertor Simulator (DASCS) which was developed by JHU/APL and simulates the operation and electrical behavior of a pair of ASC's in real time via a combination of hardware and software. RSIL provides insight into the electrical interactions between a representative radioisotope power generator, its associated control schemes, and realistic electric system loads. The first phase of integration testing included the following spacecraft bus configurations: capacitive, battery, and supercapacitor. A load profile, created based on data from several missions, tested the RPS and RSIL ability to maintain operation during load demands above and below the power provided by the RPS. The integration testing also confirmed the DCC's ability to disconnect from the spacecraft when the bus voltage dipped below 22 V or exceeded 36 V. Once operation was verified with the DASCS, the tests were repeated with actual operating ASC's. The goal of this integration testing was to verify operation of the DCC when connected to a spacecraft and to verify the functionality of the newly designed RSIL. The results of these tests are presented in this paper.

  7. Clinical and Laboratory Characteristics of Dengue-Orientia tsutsugamushi co-Infection from a Tertiary Care Center in South India

    PubMed Central

    Basheer, Aneesh; Iqbal, Nayyar; Mookkappan, Sudhagar; Anitha, Patricia; Nair, Shashikala; Kanungo, Reba; Kandasamy, Ravichandran

    2016-01-01

    Background Concurrent infection with multiple pathogens is common in tropics, posing diagnostic and treatment challenges. Although co-infections of dengue, malaria, leptospirosis and typhoid in various combinations have been described, data on dengue and scrub typhus co-infection is distinctly limited. Methodology This study was a retrospective analysis of dengue and scrub typhus co-infection diagnosed between January 2010 and July 2014 at a tertiary care center. Clinical and laboratory features of these cases were compared with age and gender-matched patients with isolated dengue fever and isolated scrub typhus. Positive test for dengue non-structural 1 (NS1) antigen was considered diagnostic of dengue whereas scrub typhus was diagnosed by IgM scrub antibodies demonstrated by ELISA. Results There were 6 cases of dengue-scrub co-infection during the review period which fitted clinical and laboratory profile with a mean age of 42.5 years. Fever, headache, and arthralgia were common. Normal hemoglobin, significant thrombocytopenia, transaminitis, and hypoalbuminemia were identified in these patients. Compared to patients with isolated dengue, those with co-infection had higher pulse rate, lower systolic blood pressure, normal leucocyte counts, higher levels of liver enzymes, greater prolongation of partial thromboplastin time (aPTT) and lower serum albumin. Co-infection was characterized by a lower nadir platelet count compared to scrub typhus, and lesser time to nadir platelet count and longer duration of hospital stay compared to either isolated dengue or scrub typhus. Conclusion Dengue-scrub typhus co-infection may be under-diagnosed in tropics, particularly confounded during dengue epidemics. Normal leukocyte counts, early drop in platelets and hypoalbuminemia in dengue patients could be clues to concurrent scrub typhus infection. Prompt recognition and treatment of scrub typhus in such cases may reduce unnecessary hospital stay and cost. PMID:27413521

  8. Cookstove Laboratory Research - Fiscal Year 2016 Report

    EPA Science Inventory

    This report provides an overview of the work conducted by the EPA cookstove laboratory research team in Fiscal Year 2016. The report describes research and activities including (1) ISO standards development, (2) capacity building for international testing and knowledge centers, ...

  9. Quantification of Soil Physical Properties by Using X-Ray Computerized Tomography (CT) and Standard Laboratory (STD) Methods

    SciTech Connect

    Sanchez, Maria Ambert

    2003-12-12

    The implementation of x-ray computerized tomography (CT) on agricultural soils has been used in this research to quantify soil physical properties to be compared with standard laboratory (STD) methods. The overall research objective was to more accurately quantify soil physical properties for long-term management systems. Two field studies were conducted at Iowa State University's Northeast Research and Demonstration Farm near Nashua, IA using two different soil management strategies. The first field study was conducted in 1999 using continuous corn crop rotation for soil under chisel plow with no-till treatments. The second study was conducted in 2001 and on soybean crop rotation for the same soil but under chisel plow and no-till practices with wheel track and no-wheel track compaction treatments induced by a tractor-manure wagon. In addition, saturated hydraulic (K{sub s}) conductivity and the convection-dispersion (CDE) model were also applied using long-term soil management systems only during 2001. The results obtained for the 1999 field study revealed no significant differences between treatments and laboratory methods, but significant differences were found at deeper depths of the soil column for tillage treatments. The results for standard laboratory procedure versus CT method showed significant differences at deeper depths for the chisel plow treatment and at the second lower depth for no-till treatment for both laboratory methods. The macroporosity distribution experiment showed significant differences at the two lower depths between tillage practices. Bulk density and percent porosity had significant differences at the two lower depths of the soil column. The results obtained for the 2001 field study showed no significant differences between tillage practices and compaction practices for both laboratory methods, but significant differences between tillage practices with wheel track and no-wheel compaction treatments were found along the soil profile for

  10. Thermal cycling for restorative materials: does a standardized protocol exist in laboratory testing? A literature review.

    PubMed

    Morresi, Anna Lucia; D'Amario, Maurizio; Capogreco, Mario; Gatto, Roberto; Marzo, Giuseppe; D'Arcangelo, Camillo; Monaco, Annalisa

    2014-01-01

    In vitro tests continue to be an indispensable method for the initial screening of dental materials. Thermal cycling is one of the most widely used procedures to simulate the physiological aging experienced by biomaterials in clinical practice. Consequently it is routinely employed in experimental studies to evaluate materials' performance. A literature review aimed to elucidate test parameters for in vitro aging of adhesive restorations was performed. This study aims to assess whether or not a standardized protocol of thermal cycling has been acknowledged from a review of the literature. An exhaustive literature search, examining the effect of thermal cycling on restorative dental materials, was performed with electronic database and by hand. The search was restricted to studies published from 1998 to August 2013. No language restrictions were applied. The search identified 193 relevant experimental studies. Only twenty-three studies had faithfully applied ISO standard. The majority of studies used their own procedures, showing only a certain consistency within the temperature parameter (5-55°C) and a great variability in the number of cycles and dwell time chosen. A wide variation in thermal cycling parameters applied in experimental studies has been identified. The parameters selected amongst these studies seem to be done on the basis of convenience for the authors in most cases. A comparison of results between studies would appear to be impossible. The available data suggest that further investigations will be required to ultimately develop a standardized thermal cycling protocol.

  11. Sorbent Testing For Solidification of Process Waste streams from the Radiochemical Engineering Development Center at Oak Ridge National Laboratory

    SciTech Connect

    Bickford, J.; Taylor, P.

    2007-07-01

    The U.S. Department of Energy (DOE) tasked MSE Technology Applications, Inc. (MSE) to evaluate sorbents identified by Oak Ridge National Laboratory (ORNL) to solidify the radioactive liquid organic waste from the Radiochemical Engineering Development Center (REDC) at ORNL. REDC recovers and purifies heavy elements (berkelium, californium, einsteinium, and fermium) from irradiated targets for research and industrial applications. Both organic and aqueous waste streams are discharged from REDC. The organic waste is generated from the plutonium/uranium extraction (Purex), Cleanex, and Pubex processes. The Purex waste derives from an organic-aqueous isotope separation process for plutonium and uranium fission products, the Cleanex waste derives from the removal of fission products and other impurities from the americium/curium product, and the Pubex waste is derived from the separation process of plutonium from dissolved targets. MSE had also been tasked to test a grouting formula for the aqueous waste stream that includes radioactive shielding material. The aqueous waste is a mixture of the raffinate streams from the various extraction processes plus the caustic solution that is used to dissolve the aluminum cladding from the irradiated targets. (authors)

  12. [Proposals for standardization of clinical laboratory studies: technology "cytological study of lymph node specimens"].

    PubMed

    Shabalova, I P; Morozova, V T; Dzhangirova, T V

    2010-11-01

    This proposal contains unique requirements for a cytological study of lymph node specimens at the cytological and clinical diagnostic laboratories of health care facilities certified for this kind of work. The paper gives requirements for the performance of technologies, for specialists and auxiliary personnel, specialists' knowledge and skills, medical staff safeguarding. The conditions for rendering a service, necessary equipment, ware, and reagents are described in details. The specific features of a pre-analytical stage, methods for the fixation and staining of smears, the interpretation and recording of findings, and the control of the quality of a performed study, as well as the cost characteristics in conventional units of man-hours. The developed technology may be of great importance to the health care facilities certified for rendering this service.

  13. Standardized pretreatment inflammatory laboratory markers and calculated ratios in patients with oral squamous cell carcinoma.

    PubMed

    Grimm, Martin; Rieth, Johan; Hoefert, Sebastian; Krimmel, Michael; Rieth, Sven; Teriete, Peter; Kluba, Susanne; Biegner, Thorsten; Munz, Adelheid; Reinert, Siegmar

    2016-10-01

    Analyzing the inflammatory microenvironment has become an important issue in the management of oral squamous cell carcinoma (OSCC). Pretreatment C-reactive protein (CRP) levels, leucocytes, monocytes, lymphocytes, neutrophils, basophils, eosinophils, platelets, neutrophil-to-lymphocyte ratio (NLR), derived NLR (dNLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) derived from the peripheral blood were analyzed. Receiver operating characteristic (ROC) curves determined a cut-off value for each parameter in 146 patients with OSCC compared with 93 controls and the results were associated with clinicopathological characteristics. CRP expression of tumors was measured by immunohistochemistry. ROC analysis determined cut-off values for CRP levels, leucocytes, monocytes, lymphocytes, neutrophils, NLR, dNLR, LMR, PLR and showed significant differences between the OSCC and control group. Compared with single laboratory tests calculated ratios were superior in measuring sensitivity and specificity of OSCC disease. NLR was significant directly associated and correlated with PLR. LMR was significant inversely associated and correlated with NLR and PLR. Immunohistochemical analysis did not show CRP expression of OSCCs. This study highlights the first analysis for cut-off values of pretreatment single laboratory tests and calculated ratios, which are strongly needed for a follow-up of cancer patients. Additionally, the calculated baselines can be used as a goal for successful immunotherapies in the future. The links between NLR, LMR, and PLR might be helpful for the clinical course (monitoring) of cancer patients and have been first described for OSCC in this study. Taken together, analyzing these data provides an additional practical guideline of further postoperative OSCC management.

  14. Improving the Informed Consent Conversation: A Standardized Checklist that Is Patient Centered, Quality Driven, and Legally Sound.

    PubMed

    Ripley, Beth A; Tiffany, David; Lehmann, Lisa S; Silverman, Stuart G

    2015-11-01

    The informed consent conversation is a key component of patient-centered medicine, a concept that emphasizes the importance of patients actively participating in their care. Studies reveal that many informed consent conversations throughout medical practice lack essential elements and leave patients' needs unmet. This review addresses these deficiencies, discusses solutions, and introduces a standardized checklist that values the patient's role in shared decision making during the informed consent conversation. The checklist could be particularly helpful to interventional radiologists and other consulting physicians who usually obtain informed consent early in their encounters with patients.

  15. [A novel method for patient-oriented assignment of wheelchair cushions based on standardized laboratory testing procedures].

    PubMed

    Diesing, P; Hochmann, D; Boenick, U; Kraft, M

    2005-06-01

    A wheelchair seat cushion represents the interface between the wheelchair and the wheelchair driver and has to manage the force transmission and the stabilization between both of them. An additional very important requirement is the prevention of pressure ulcers by pressure relief and the transfer of humidity and heat away from the patient. The allocation of a cushion to the patient happens normally on the base of a subjective description of the cushion without any transparent decision rules. Consequently the quality of this procedure could be improved by a better description of the cushion, based on standardized laboratory tests and by the development of decision tools helping to identify the main efforts of the user. This article describes a procedure that allows the allocation of wheelchair seat cushions based on the characteristic of cushions from standardized laboratory tests and on the brief description of the user. Additionally the existing principles for wheelchair cushions are listed, described and compared. The possibilities to develop structured decision tools for wheelchair cushions are discussed.

  16. Impact of new Clinical Laboratory Standards Institute Streptococcus pneumoniae penicillin susceptibility testing breakpoints on reported resistance changes over time.

    PubMed

    Mera, Robertino M; Miller, Linda A; Amrine-Madsen, Heather; Sahm, Daniel F

    2011-03-01

    The analysis comprised a total of 97,843 U.S. isolates from the Surveillance Network(®) database for the period 1996-2008. Penicillin resistance, when defined using the old Clinical Laboratory Standards Institute breakpoint (≥2 μg/ml), had an initial rise that started in 1996, peaked in 2000, declined until 2003, and rebounded through 2008 (15.6%, 23.2%, 15.4%, and 16.9%, respectively). Using the new Clinical Laboratory Standards Institute criteria and applying a breakpoint of ≥8 μg/ml to blood and bronchial isolates, resistance was unchanged (0.24% in 2003) but rose to 1.52% in 2008. Using the new meningitis criteria (≥0.12 μg/ml), resistance prevalence was 34.8% in 2008, whereas it was 12.3% using the old criteria (≥2 μg/ml) for cerebrospinal fluid isolates. The rise, fall, and subsequent rebound of penicillin resistance in the United States, presumably influenced by the introduction of the conjugate pneumococcal vaccine, is clearly seen with the old definition, but only the rebound is seen when the new criteria are applied. In the postvaccine period, isolates with minimum inhibitory concentrations of 1 and 2 μg/ml decline, whereas those with minimum inhibitory concentrations of 0.12-0.5 increase, which may signal the loss of resistant vaccine serotypes and the acquisition of resistance by nonvaccine serotypes.

  17. Ecological risk assessment of substances with suspected estrogenic activity using standard laboratory fish tests

    SciTech Connect

    Gimeno, S.; Bowmer, C.T.

    1999-07-01

    The assessment of risks to the aquatic environment in the European Union is generally based on a comparison of Predicted Environmental Concentrations (PEC) with Predicted No Effect Concentrations (PNEC) for surrogate, or representative, organisms of the receiving waters. Such risk assessments are required for new and priority existing chemicals, pesticides, and, in the near future, biocides; they are dependent on robust in vivo test data. Current strategies for ecological risk assessment were not designed to assess the risk of endocrine disrupters. The selection of suitable fish species and practical in vivo end points for determining endocrine disruption in fish are discussed, including the adaptation of some existing guidelines. This paper is partly based on a series of experiments conducted at the laboratory to look at the effects of a model alkylphenol (4-tert-pentylphenol), an industrial chemical intermediate, acting as a pseudo-estrogen on an all-male population of the common carp, Cyprinus carpio. Exposure to the test substance occurred at critical life stages for endocrine disruption. Biochemical parameters as well as histological parameters were applied, and their suitability to be used in ecological risk assessment is discussed.

  18. Suitability of the echo-time-shift method as laboratory standard for thermal ultrasound dosimetry

    NASA Astrophysics Data System (ADS)

    Fuhrmann, Tina; Georg, Olga; Haller, Julian; Jenderka, Klaus-Vitold

    2017-03-01

    Ultrasound therapy is a promising, non-invasive application with potential to significantly improve cancer therapies like surgery, viro- or immunotherapy. This therapy needs faster, cheaper and more easy-to-handle quality assurance tools for therapy devices as well as possibilities to verify treatment plans and for dosimetry. This limits comparability and safety of treatments. Accurate spatial and temporal temperature maps could be used to overcome these shortcomings. In this contribution first results of suitability and accuracy investigations of the echo-time-shift method for two-dimensional temperature mapping during and after sonication are presented. The analysis methods used to calculate time-shifts were a discrete frame-to-frame and a discrete frame-to-base-frame algorithm as well as a sigmoid fit for temperature calculation. In the future accuracy could be significantly enhanced by using continuous methods for time-shift calculation. Further improvements can be achieved by improving filtering algorithms and interpolation of sampled diagnostic ultrasound data. It might be a comparatively accurate, fast and affordable method for laboratory and clinical quality control.

  19. [Standardization of activities in an oncology surgical center according to nursing intervention classification].

    PubMed

    Possari, João Francisco; Gaidzinski, Raquel Rapone; Fugulin, Fernanda Maria Togeiro; Lima, Antônio Fernandes Costa; Kurcgant, Paulina

    2013-06-01

    This study was undertaken in a surgical center specializing in oncology, and it aimed to identify nursing activities performed during the perioperative period and to classify and validate intervention activities according to the Nursing Interventions Classification (NIC). A survey of activities was conducted using records and by direct observation of nursing care across four shifts. Activities were classified as NIC nursing interventions using the cross-mapping technique. The list of interventions was validated by nursing professionals in workshops. Forty-nine interventions were identified: 34 of direct care and 15 of indirect care. Identifying nursing interventions facilitates measuring the time spent in their execution, which is a fundamental variable in the quantification and qualification of nurses' workloads.

  20. Standardized ultrasound evaluation of carotid stenosis for clinical trials: University of Washington Ultrasound Reading Center

    PubMed Central

    2010-01-01

    Introduction Serial monitoring of patients participating in clinical trials of carotid artery therapy requires noninvasive precision methods that are inexpensive, safe and widely available. Noninvasive ultrasonic duplex Doppler velocimetry provides a precision method that can be used for recruitment qualification, pre-treatment classification and post treatment surveillance for remodeling and restenosis. The University of Washington Ultrasound Reading Center (UWURC) provides a uniform examination protocol and interpretation of duplex Doppler velocity measurements. Methods Doppler waveforms from 6 locations along the common carotid and internal carotid artery path to the brain plus the external carotid and vertebral arteries on each side using a Doppler examination angle of 60 degrees are evaluated. The UWURC verifies all measurements against the images and waveforms for the database, which includes pre-procedure, post-procedure and annual follow-up examinations. Doppler angle alignment errors greater than 3 degrees and Doppler velocity measurement errors greater than 0.05 m/s are corrected. Results Angle adjusted Doppler velocity measurements produce higher values when higher Doppler examination angles are used. The definition of peak systolic velocity varies between examiners when spectral broadening due to turbulence is present. Examples of measurements are shown. Discussion Although ultrasonic duplex Doppler methods are widely used in carotid artery diagnosis, there is disagreement about how the examinations should be performed and how the results should be validated. In clinical trails, a centralized reading center can unify the methods. Because the goals of research examinations are different from those of clinical examinations, screening and diagnostic clinical examinations may require fewer velocity measurements. PMID:20822530

  1. Virtual Global Transplant Laboratory Standard Operating Procedures for Blood Collection, PBMC Isolation, and Storage

    PubMed Central

    Higdon, Lauren E.; Lee, Karim; Tang, Qizhi; Maltzman, Jonathan S.

    2016-01-01

    Abstract Research on human immune responses frequently involves the use of peripheral blood mononuclear cells (PBMC) immediately, or at significantly delayed timepoints, after collection. This requires PBMC isolation from whole blood and cryopreservation for some applications. It is important to standardize protocols for blood collection, PBMC isolation, cryopreservation, and thawing that maximize survival and functionality of PBMC at the time of analysis. This resource includes detailed protocols describing blood collection tubes, isolation of PBMC using a density gradient, cryopreservation of PBMC, and thawing of cells as well as preparation for functional assays. For each protocol, we include important considerations, such as timing, storage temperatures, and freezing rate. In addition, we provide alternatives so that researchers can make informed decisions in determining the optimal protocol for their application. PMID:27795993

  2. Virtual Global Transplant Laboratory Standard Operating Procedures for Blood Collection, PBMC Isolation, and Storage.

    PubMed

    Higdon, Lauren E; Lee, Karim; Tang, Qizhi; Maltzman, Jonathan S

    2016-09-01

    Research on human immune responses frequently involves the use of peripheral blood mononuclear cells (PBMC) immediately, or at significantly delayed timepoints, after collection. This requires PBMC isolation from whole blood and cryopreservation for some applications. It is important to standardize protocols for blood collection, PBMC isolation, cryopreservation, and thawing that maximize survival and functionality of PBMC at the time of analysis. This resource includes detailed protocols describing blood collection tubes, isolation of PBMC using a density gradient, cryopreservation of PBMC, and thawing of cells as well as preparation for functional assays. For each protocol, we include important considerations, such as timing, storage temperatures, and freezing rate. In addition, we provide alternatives so that researchers can make informed decisions in determining the optimal protocol for their application.

  3. A Multi-Center Space Data System Prototype Based on CCSDS Standards

    NASA Technical Reports Server (NTRS)

    Rich, Thomas M.

    2016-01-01

    Deep space missions beyond earth orbit will require new methods of data communications in order to compensate for increasing RF propagation delay. The Consultative Committee for Space Data Systems (CCSDS) standard protocols Spacecraft Monitor & Control (SM&C), Asynchronous Message Service (AMS), and Delay/Disruption Tolerant Networking (DTN) provide such a method. The maturity level of this protocol set is, however, insufficient for mission inclusion at this time. This prototype is intended to provide experience which will raise the Technical Readiness Level (TRL) of these protocols..

  4. Improving communication skill training in patient centered medical practice for enhancing rational use of laboratory tests: The core of bioinformation for leveraging stakeholder engagement in regulatory science.

    PubMed

    Moura, Josemar de Almeida; Costa, Bruna Carvalho; de Faria, Rosa Malena Delbone; Soares, Taciana Figueiredo; Moura, Eliane Perlatto; Chiappelli, Francesco

    2013-01-01

    Requests for laboratory tests are among the most relevant additional tools used by physicians as part of patient's health problemsolving. However, the overestimation of complementary investigation may be linked to less reflective medical practice as a consequence of a poor physician-patient communication, and may impair patient-centered care. This scenario is likely to result from reduced consultation time, and a clinical model focused on the disease. We propose a new medical intervention program that specifically targets improving the patient-centered communication of laboratory tests results, the core of bioinformation in health care. Expectations are that medical students training in communication skills significantly improve physicians-patient relationship, reduce inappropriate use of laboratorial tests, and raise stakeholder engagement.

  5. 42 CFR 493.1355 - Condition: Laboratories performing PPM procedures; laboratory director.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Condition: Laboratories performing PPM procedures; laboratory director. 493.1355 Section 493.1355 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY...

  6. 42 CFR 493.1355 - Condition: Laboratories performing PPM procedures; laboratory director.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Condition: Laboratories performing PPM procedures; laboratory director. 493.1355 Section 493.1355 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY...

  7. 42 CFR 493.1355 - Condition: Laboratories performing PPM procedures; laboratory director.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false Condition: Laboratories performing PPM procedures; laboratory director. 493.1355 Section 493.1355 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY...

  8. 42 CFR 493.1355 - Condition: Laboratories performing PPM procedures; laboratory director.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Condition: Laboratories performing PPM procedures; laboratory director. 493.1355 Section 493.1355 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY...

  9. 42 CFR 493.1355 - Condition: Laboratories performing PPM procedures; laboratory director.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 5 2014-10-01 2014-10-01 false Condition: Laboratories performing PPM procedures; laboratory director. 493.1355 Section 493.1355 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY...

  10. United States Air Force Summer Research Program -- 1993. Volume 16. Arnold Engineering Development Center. Frank J. Seiler Research Laboratory. Wilford Hall Medical Center

    DTIC Science & Technology

    1993-12-01

    Master Index For High School Apprentices Ackermann, Laura Laboratory: PL/LI 7801 Wilshire H Vol-Paqe No: 13- 5 La Cueva High School Albuquerque, 1HK...Wilshire Blvd. Vol-Page No: 13- 6 La Cueva High School Albuquerque, M 87122-0000 Felderman, James Laboratory: AEDC/ N. Jackson St. Vol-Page No: 16- 2...500 Z. Franklin St. Vol-Page No: 15-23 Centerville Sigh School Centerville, OH 45459-0000 Gonzalez , Christopher Laboratory: AL/OK 1400 Jackson-Keller

  11. United States Air Force Summer Research Program -- 1993. Volume 6. Arnold Engineering Development Center, Frank J. Seiler Research Laboratory, Wilford Hall Medical Center

    DTIC Science & Technology

    1993-12-01

    Science Dept, CMI. gz cs, PhD Laboratory: PL/VT 3200 Willow Creek Road Embry-Riddle Aeronautical Univ Vol-Page No: 3-24 Prescott , AZ 86301-0000 Belle... Prescott , AZ 86301-0000 Bhuyan, Jay Field: computer Science Assistant Professor, PhD Laboratory: PL/WS Dept. ofComputer Science Tuskegee University...No: 5- 2 Prescott , AZ 86301-3720 Cundari, Thomas Field: Department of Chemistry Assistant Professor, PhD Laboratory: PL/RK Jim Smith Building MAmphis

  12. IDAHO NATIONAL LABORATORY TRANSPORTATION TASK REPORT ON ACHIEVING MODERATOR EXCLUSION AND SUPPORTING STANDARDIZED TRANSPORTATION

    SciTech Connect

    D.K. Morton

    2011-09-01

    Following the defunding of the Yucca Mountain Project, it is reasonable to assume that commercial used fuel will remain in storage for the foreseeable future. This report proposes supplementing the ongoing research and development work related to potential degradation of used fuel, baskets, poisons, and storage canisters during an extended period of storage with a parallel path. This parallel path can assure criticality safety during transportation by implementing a concept that achieves moderator exclusion (no in-leakage of moderator into the used fuel cavity). Using updated risk assessment insights for additional technical justification and relying upon a component inside of the transportation cask that provides a watertight function, a strong argument can be made that moderator intrusion is not credible and should not be a required assumption for criticality evaluations during normal conditions of transportation. A demonstrating testing program supporting a detailed analytical effort as well as updated risk assessment insights can provide the basis for moderator exclusion during hypothetical accident conditions. This report also discusses how this engineered concept can support the goal of standardized transportation.

  13. Presentation on the Modeling and Educational Demonstrations Laboratory Curriculum Materials Center (MEDL-CMC): A Working Model and Progress Report

    NASA Astrophysics Data System (ADS)

    Glesener, G. B.; Vican, L.

    2015-12-01

    Physical analog models and demonstrations can be effective educational tools for helping instructors teach abstract concepts in the Earth, planetary, and space sciences. Reducing the learning challenges for students using physical analog models and demonstrations, however, can often increase instructors' workload and budget because the cost and time needed to produce and maintain such curriculum materials is substantial. First, this presentation describes a working model for the Modeling and Educational Demonstrations Laboratory Curriculum Materials Center (MEDL-CMC) to support instructors' use of physical analog models and demonstrations in the science classroom. The working model is based on a combination of instructional resource models developed by the Association of College & Research Libraries and by the Physics Instructional Resource Association. The MEDL-CMC aims to make the curriculum materials available for all science courses and outreach programs within the institution where the MEDL-CMC resides. The sustainability and value of the MEDL-CMC comes from its ability to provide and maintain a variety of physical analog models and demonstrations in a wide range of science disciplines. Second, the presentation then reports on the development, progress, and future of the MEDL-CMC at the University of California Los Angeles (UCLA). Development of the UCLA MEDL-CMC was funded by a grant from UCLA's Office of Instructional Development and is supported by the Department of Earth, Planetary, and Space Sciences. Other UCLA science departments have recently shown interest in the UCLA MEDL-CMC services, and therefore, preparations are currently underway to increase our capacity for providing interdepartmental service. The presentation concludes with recommendations and suggestions for other institutions that wish to start their own MEDL-CMC in order to increase educational effectiveness and decrease instructor workload. We welcome an interuniversity collaboration to

  14. The benefits of pulsatile machine perfusion of standard criteria deceased donor kidneys at a geographically remote transplant center.

    PubMed

    Chueh, Shih-Chieh Jeff; Sankari, Bashir R; Lipscomb, Lorie; Modak, Asmita; Castello, Michael G; Avallone, Edwin J

    2014-01-01

    Benefits of pulsatile machine perfusion (pumping) of standard criteria donor (SCD) kidneys are unclear. Our center is located 4½ hours from our Organ Procurement Organization. We evaluated outcomes of pumping SCD kidneys under such circumstances by conducting a retrospective examination of all SCD kidneys transplanted between January 2007 and March 2012, comparing kidneys pumped (28 [group 1]) versus standard cold storage (77 [group 2]). Group 1 had fewer delayed graft function (DGF, 3.57% vs. 23.38%, p = 0.02) and slow graft function (SGF, 7.14% vs. 24.68%; p = 0.047) and faster serum creatinine recovery curve (p < 0.001) than group 2. Having a kidney pumped decreases the incidence (odds ratio [OR], 0.059) of DGF, SGF, or primary nonfunction. Group 1 were quicker to reach an estimated glomerular filtration rate (eGFR) >30 ml/min (OR, 4.186; confidence interval [CI], [2.448-7.157]) or an eGFR >60 ml/min (OR, 2.669; CI [1.255-5.679]). Pumping the SCD kidneys in a geographically remote transplant center tended to be better than those preserved in cold storage. However, except recovery curve of serum creatinine during the first postoperative month, other parameters failed to reach statistical significance in the post hoc examination of the contemporary groups. Prospective paired kidney study is required to scrutinize this finding.

  15. Malaria Diagnosis across the International Centers of Excellence for Malaria Research: Platforms, Performance, and Standardization

    PubMed Central

    Kobayashi, Tamaki; Gamboa, Dionicia; Ndiaye, Daouda; Cui, Liwang; Sutton, Patrick L.; Vinetz, Joseph M.

    2015-01-01

    Diagnosis is “the act of identifying a disease, illness, or problem by examining someone or something.” When an individual with acute fever presents for clinical attention, accurate diagnosis leading to specific, prompt treatment often saves lives. As applied to malaria, not only individual patient diagnosis is important but also assessing population-level malaria prevalence using appropriate diagnostic methods is essential for public health purposes. Similarly, identifying (diagnosing) fake antimalarial medications prevents the use of counterfeit drugs that can have disastrous effects. Therefore, accurate diagnosis in broad areas related to malaria is fundamental to improving health-care delivery, informing funding agencies of current malaria situations, and aiding in the prioritization of regional and national control efforts. The International Centers of Excellence for Malaria Research (ICEMR), supported by the U.S. National Institute of Allergy and Infectious Diseases, has collaborated on global efforts to improve malaria diagnostics by working to harmonize and systematize procedures across different regions where endemicity and financial resources vary. In this article, the different diagnostic methods used across each ICEMR are reviewed and challenges are discussed. PMID:26259937

  16. Malaria Diagnosis Across the International Centers of Excellence for Malaria Research: Platforms, Performance, and Standardization.

    PubMed

    Kobayashi, Tamaki; Gamboa, Dionicia; Ndiaye, Daouda; Cui, Liwang; Sutton, Patrick L; Vinetz, Joseph M

    2015-09-01

    Diagnosis is "the act of identifying a disease, illness, or problem by examining someone or something." When an individual with acute fever presents for clinical attention, accurate diagnosis leading to specific, prompt treatment often saves lives. As applied to malaria, not only individual patient diagnosis is important but also assessing population-level malaria prevalence using appropriate diagnostic methods is essential for public health purposes. Similarly, identifying (diagnosing) fake antimalarial medications prevents the use of counterfeit drugs that can have disastrous effects. Therefore, accurate diagnosis in broad areas related to malaria is fundamental to improving health-care delivery, informing funding agencies of current malaria situations, and aiding in the prioritization of regional and national control efforts. The International Centers of Excellence for Malaria Research (ICEMR), supported by the U.S. National Institute of Allergy and Infectious Diseases, has collaborated on global efforts to improve malaria diagnostics by working to harmonize and systematize procedures across different regions where endemicity and financial resources vary. In this article, the different diagnostic methods used across each ICEMR are reviewed and challenges are discussed.

  17. Implementing Qualitative Data Management Plans to Ensure Ethical Standards in Multi-partner Centers

    PubMed Central

    Hardy, LJ; Hughes, A; Hulen, E; Schwartz, A

    2015-01-01

    Thorough data management is crucial for the protection of people who participate in research and researcher ability to share results with the public. The impact of inadequate adherence to data management is particularly evident in small field sites and among vulnerable populations. Community-based Participatory Research (CBPR) presents exciting opportunities for multimedia and multi-sectoral dissemination of research results and policy change, especially concerning the impact of research on health equity for underrepresented populations. In this article we discuss how we defined data boundaries and protections to adhere to ethical standards while also prioritizing data dissemination. Although complex partnerships can introduce additional risks to data oversight, data management practices can also increase opportunities for wide-reaching dissemination. We hope to contribute to the literature on data sharing in multi-partnership projects to bolster the impact of dissemination while also protecting participants and populations who chose to collaborate in research and policy practices. PMID:27074911

  18. 1996 Idaho National Engineering and Environmental Laboratory (INEEL) National Emissions Standards for Hazardous Air Pollutants (NESHAPs) -- Radionuclides. Annual report

    SciTech Connect

    1997-06-01

    Under Section 61.94 of Title 40, Code of Federal Regulations (CFR), Part 61, Subpart H, ``National Emission Standards for Emissions of Radionuclides Other Than Radon From Department of Energy Facilities,`` each Department of Energy (DOE) facility must submit an annual report documenting compliance. This report addresses the Section 61.94 reporting requirements for operations at the Idaho National Engineering and Environmental Laboratory (INEEL) for calendar year (CY) 1996. The Idaho Operations Office of the DOE is the primary contact concerning compliance with the National Emission Standards for Hazardous Air Pollutants (NESHAPs) at the INEEL. For calendar year 1996, airborne radionuclide emissions from the INEEL operations were calculated to result in a maximum individual dose to a member of the public of 3.14E-02 mrem (3.14E-07 Sievert). This effective dose equivalent (EDE) is well below the 40 CFR 61, Subpart H, regulatory standard of 10 mrem per year (1.0E-04 Sievert per year).

  19. Quality-assurance plan for the analysis of fluvial sediment by the U.S. Geological Survey Kentucky Water Science Center Sediment Laboratory

    USGS Publications Warehouse

    Shreve, Elizabeth A.; Downs, Aimee C.

    2005-01-01

    This report describes laboratory procedures used by the U.S. Geological Survey Kentucky Water Science Center Sediment Laboratory for the processing and analysis of fluvial-sediment samples for concentration of sand and finer material. The report details the processing of a sediment sample through the laboratory from receiving the sediment sample, through the analytical process, to compiling results of the requested analysis. Procedures for preserving sample integrity, calibrating and maintaining of laboratory and field instruments and equipment, analyzing samples, internal quality assurance and quality control, and validity of the sediment-analysis results also are described. The report includes a list of references cited and a glossary of sediment and quality-assurance terms.

  20. Standardized transportation of human islets: an islet cell resource center study of more than 2,000 shipments.

    PubMed

    Kaddis, John S; Hanson, Matthew S; Cravens, James; Qian, Dajun; Olack, Barbara; Antler, Martha; Papas, Klearchos K; Iglesias, Itzia; Barbaro, Barbara; Fernandez, Luis; Powers, Alvin C; Niland, Joyce C

    2013-01-01

    Preservation of cell quality during shipment of human pancreatic islets for use in laboratory research is a crucial, but neglected, topic. Mammalian cells, including islets, have been shown to be adversely affected by temperature changes in vitro and in vivo, yet protocols that control for thermal fluctuations during cell transport are lacking. To evaluate an optimal method of shipping human islets, an initial assessment of transportation conditions was conducted using standardized materials and operating procedures in 48 shipments sent to a central location by eight pancreas-processing laboratories using a single commercial airline transporter. Optimization of preliminary conditions was conducted, and human islet quality was then evaluated in 2,338 shipments pre- and postimplementation of a finalized transportation container and standard operating procedures. The initial assessment revealed that the outside temperature ranged from a mean of -4.6 ± 10.3°C to 20.9 ± 4.8°C. Within-container temperature drops to or below 15°C occurred in 16 shipments (36%), while the temperature was found to be stabilized between 15°C and 29°C in 29 shipments (64%). Implementation of an optimized transportation container and operating procedure reduced the number of within-container temperature drops (≤ 15°C) to 13% (n = 37 of 289 winter shipments), improved the number desirably maintained between 15°C and 29°C to 86% (n = 250), but also increased the number reaching or exceeding 29°C to 1% (n = 2; overall p < 0.0001). Additionally, postreceipt quality ratings of excellent to good improved pre- versus postimplantation of the standardized protocol, adjusting for preshipment purity/viability levels (p < 0.0001). Our results show that extreme temperature fluctuations during transport of human islets, occurring when using a commercial airline transporter for long distance shipping, can be controlled using standardized containers, materials, and operating procedures. This cost

  1. Method of analysis at the U.S. Geological Survey California Water Science Center, Sacramento Laboratory - determination of haloacetic acid formation potential, method validation, and quality-control practices

    USGS Publications Warehouse

    Zazzi, Barbara C.; Crepeau, Kathryn L.; Fram, Miranda S.; Bergamaschi, Brian A.

    2005-01-01

    An analytical method for the determination of haloacetic acid formation potential of water samples has been developed by the U.S. Geological Survey California Water Science Center Sacramento Laboratory. The haloacetic acid formation potential is measured by dosing water samples with chlorine under specified conditions of pH, temperature, incubation time, darkness, and residual-free chlorine. The haloacetic acids formed are bromochloroacetic acid, bromodichloroacetic acid, dibromochloroacetic acid, dibromoacetic acid, dichloroacetic acid, monobromoacetic acid, monochloroacetic acid, tribromoacetic acid, and trichloroacetic acid. They are extracted, methylated, and then analyzed using a gas chromatograph equipped with an electron capture detector. Method validation experiments were performed to determine the method accuracy, precision, and detection limit for each of the compounds. Method detection limits for these nine haloacetic acids ranged from 0.11 to 0.45 microgram per liter. Quality-control practices include the use of blanks, quality-control samples, calibration verification standards, surrogate recovery, internal standard, matrix spikes, and duplicates.

  2. 1997 Idaho National Engineering and Environmental Laboratory (INEEL) National Emission Standards for Hazardous Air Pollutants (NESHAPs) -- Radionuclides annual report

    SciTech Connect

    1998-06-01

    Under Section 61.94 of Title 40, Code of Federal Regulations (CFR), Part 61, Subpart H, National Emission Standards for Emissions of Radionuclides Other Than Radon From Department of Energy Facilities, each Department of Energy (DOE) facility must submit an annual report documenting compliance. This report addresses the Section 61.94 reporting requirements for operations at the Idaho National Engineering and Environmental Laboratory (INEEL) for calendar year (CY) 1997. Section 1 of this report provides an overview of the INEEL facilities and a brief description of the radioactive materials and processes at the facilities. Section 2 identifies radioactive air effluent release points and diffuse sources at the INEEL and actual releases during 1997. Section 2 also describes the effluent control systems for each potential release point. Section 3 provides the methodology and EDE calculations for 1997 INEEL radioactive emissions.

  3. Design of a medical and laboratory equipment management program for the new standards certification achievement in Mexico.

    PubMed

    Franco-Clark, D; Pimentel-Aguilar, A B; Rodriguez-Vera, R

    2010-01-01

    Certification for healthcare institutions in Mexico is ruled by 2009 standards homologated with the Joint Commission International criteria. Nowadays, healthcare requires of medical equipment and devices, so it has become necessary to implement guidelines for its adequate management in order to reach the highest level of quality and safety at the lowest cost. The objective of this work was to develop a Medical and Laboratory Equipment Management Program, oriented to the improvement of quality, effectiveness and efficiency of the technological resources in order to meet the certification requirements. The result of this work allows to have an auto evaluation tool that focuses the efforts of the National Institute for Respiratory Diseases to the achievement of the new requirements established for the certification.

  4. Gateway to the Future. Skill Standards for the Bioscience Industry for Technical Workers in Pharmaceutical Companies, Biotechnology Companies, and Clinical Laboratories.

    ERIC Educational Resources Information Center

    Education Development Center, Inc., Newton, MA.

    The Bioscience Industry Skills Standards Project (BISSP) is developing national, voluntary skill standards for technical jobs in biotechnology and pharmaceutical companies and clinical laboratories in hospitals, universities, government, and independent settings. Research with employees and educators has pinpointed three issues underscoring the…

  5. Statistical methods for establishing quality control ranges for antibacterial agents in Clinical and Laboratory Standards Institute susceptibility testing.

    PubMed

    Turnidge, John; Bordash, Gerry

    2007-07-01

    Quality control (QC) ranges for antimicrobial agents against QC strains for both dilution and disk diffusion testing are currently set by the Clinical and Laboratory Standards Institute (CLSI), using data gathered in predefined structured multilaboratory studies, so-called tier 2 studies. The ranges are finally selected by the relevant CLSI subcommittee, based largely on visual inspection and a few simple rules. We have developed statistical methods for analyzing the data from tier 2 studies and applied them to QC strain-antimicrobial agent combinations from 178 dilution testing data sets and 48 disk diffusion data sets, including a method for identifying possible outlier data from individual laboratories. The methods are based on the fact that dilution testing MIC data were log normally distributed and disk diffusion zone diameter data were normally distributed. For dilution testing, compared to QC ranges actually set by CLSI, calculated ranges were identical in 68% of cases, narrower in 7% of cases, and wider in 14% of cases. For disk diffusion testing, calculated ranges were identical to CLSI ranges in 33% of cases, narrower in 8% of cases, and 1 to 2 mm wider in 58% of cases. Possible outliers were detected in 8% of diffusion test data but none of the disk diffusion data. Application of statistical techniques to the analysis of QC tier 2 data and the setting of QC ranges is relatively simple to perform on spreadsheets, and the output enhances the current CLSI methods for setting of QC ranges.

  6. 42 CFR 493.1234 - Standard: Communications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Standard: Communications. 493.1234 Section 493.1234 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Laboratory Systems § 493.1234 Standard: Communications. The laboratory must have a system in place...

  7. Analysis of the Use of Defense Technical Information Center Resources By Research and Development Centers and Laboratories in the U.S. Army

    DTIC Science & Technology

    1985-11-08

    Aviation Research andTagtAustonLb Technology Labs. -Electronic Warfare Lab. LAerOochanica Lab Electronics TechnologyI and Devices Lab. Appliad...technology Tank-Automotive Lab Tank-automotive weapons and equipment systems technology Belvoir R&D Center Mobility /counter- mobility research and engineering

  8. Lawrence Livermore National Laboratory Quality Assurance Project Plan for National Emission Standards for Hazardous Air Pollutants (NESHAPs), Subpart H

    SciTech Connect

    Hall, L.; Biermann, A

    2000-06-27

    As a Department of Energy (DOE) Facility whose operations involve the use of radionuclides, Lawrence Livermore National Laboratory (LLNL) is subject to the requirements of 40 CFR 61, the National Emission Standards for Hazardous Air Pollutants (NESHAPs). Subpart H of this Regulation establishes standards for exposure of the public to radionuclides (other than radon) released from DOE Facilities (Federal Register, 1989). These regulations limit the emission of radionuclides to ambient air from DOE facilities (see Section 2.0). Under the NESHAPs Subpart H Regulation (hereafter referred to as NESHAPs), DOE facilities are also required to establish a quality assurance program for radionuclide emission measurements; specific requirements for preparation of a Quality Assurance Program Plan (QAPP) are given in Appendix B, Method 114 of 40 CFR 61. Throughout this QAPP, the specific Quality Assurance Method elements of 40 CFR 61 Subpart H addressed by a given section are identified. In addition, the US Environmental Protection Agency (US EPA) (US EPA, 1994a) published draft requirements for QAPP's prepared in support of programs that develop environmental data. We have incorporated many of the technical elements specified in that document into this QAPP, specifically those identified as relating to measurement and data acquisition; assessment and oversight; and data validation and usability. This QAPP will be evaluated on an annual basis, and updated as appropriate.

  9. Current Performance Characteristics of NASA Langley Research Center's Cockpit Motion Base and Standardized Test Procedure for Future Performance Characterization

    NASA Technical Reports Server (NTRS)

    Cowen, Brandon; Stringer, Mary T.; Hutchinson, Brian K.; Davidson, Paul C.; Gupton, Lawrence E.

    2014-01-01

    This report documents the updated performance characteristics of NASA Langley Research Center's (LaRC) Cockpit Motion Base (CMB) after recent revisions that were made to its inner-loop, feedback control law. The modifications to the control law will be briefly described. The performance of the Cockpit Motion Facility (CMF) will be presented. A short graphical comparison to the previous control law can be found in the appendix of this report. The revised controller will be shown to yield reduced parasitic accelerations with respect to the previous controller. Metrics based on the AGARD Advisory Report No. 144 are used to assess the overall system performance due to its recent control algorithm modification. This report also documents the standardized simulator test procedure which can be used in the future to evaluate potential updates to the control law.

  10. Use of medicines and adherence to standard treatment guidelines in rural community health centers, Timor-Leste.

    PubMed

    Higuchi, Michiyo; Okumura, Junko; Aoyama, Atsuko; Suryawati, Sri; Porter, John

    2015-03-01

    The use of medicines and nurses'/midwives' adherence to standard treatment guidelines (STGs) were examined in Timor-Leste during the early stage of the nation's new health system development. A cross-sectional study was conducted as the quantitative element of mixed methods research. Retrospective samples from patient registration books and prospective observations were obtained in 20 randomly selected rural community health centers. The medicines use indicators, in particular the level of injection use, in Timor-Leste did not suggest overprescription. Prescribers with clinical nurse training prescribed significantly fewer antibiotics than those without such training (P < .01). The adjusted odds ratio of prescribing adherence for clinical nurse training, after accounting for confounders and prescriber clustering, was 6.6 (P < .01). STGs for nonphysician health professionals at the primary health care level have potential value in basic health care delivery, including appropriate use of medicines, in resource-limited communities when strategically developed and introduced.

  11. Feasibility of Key Star Wars Technology at Center of Debate over Information a Cal. Laboratory Gave Government.

    ERIC Educational Resources Information Center

    McDonald, Kim

    1988-01-01

    The question of whether a university is responsible for the technical accuracy of information released by senior administrators of a laboratory it is charged with overseeing is examined in the case involving a dispute at the Lawrence Livermore National Laboratory that is overseen by the University of California. (MLW)

  12. LabView Based Nuclear Physics Laboratory experiments as a remote teaching and training tool for Latin American Educational Centers

    SciTech Connect

    Sajo-Bohus, L.; Greaves, E. D.; Barros, H.; Gonzalez, W.; Rangel, A.

    2007-10-26

    A virtual laboratory via internet to provide a highly iterative and powerful teaching tool for scientific and technical discipline is given. The experimenter takes advantage of a virtual laboratory and he can execute nuclear experiment at introductory level e.g. Gamma ray detection with Geiger-Mueller Counter at remote location using internet communication technology.

  13. Computer-Aided Engineering and Documentation System (CAEDOS) Productivity Study, Director of Navy Laboratories Research and Development Centers.

    DTIC Science & Technology

    1986-04-01

    CAE Survey Outline ........................... 21 D. Navy Laboratory CAD/CAM/CAE Survey Questionnaires .................... 23 E . Laboratory Profiles...87 F. Survey Questionnaire Responses ............................................ 89 G...reflecting on productivity as it relates to CAEDOS. Accordingly, it was decided that a questionnaire would be used to obtain individual opinions as to

  14. Illinois Department of Children and Family Services Text of Adopted Rules. Subchapter e: Requirements for Licensure. Part 407: Licensing Standards for Day Care Centers.

    ERIC Educational Resources Information Center

    Illinois State Dept. of Children and Family Services, Springfield.

    Reprinted in this document are day care center licensing standards adopted and codified, effective August 1983, by the Illinois Department of Children and Family Services and amended June 1984 and January 1985. Sections of the report concern purpose, definitions, effective date of standards, application for license and license renewal, provisions…

  15. TREAT Asia Quality Assessment Scheme (TAQAS) to standardize the outcome of HIV genotypic resistance testing in a group of Asian laboratories.

    PubMed

    Land, Sally; Cunningham, Philip; Zhou, Jialun; Frost, Kevin; Katzenstein, David; Kantor, Rami; Chen, Yi-Ming Arthur; Oka, Shinichi; DeLong, Allison; Sayer, David; Smith, Jeffery; Dax, Elizabeth M; Law, Matthew

    2009-08-01

    The TREAT Asia (Therapeutics, Research, Education, and AIDS Training in Asia) Network is building capacity for Human Immunodeficiency Virus Type-1 (HIV-1) drug resistance testing in the region. The objective of the TREAT Asia Quality Assessment Scheme - designated TAQAS - is to standardize HIV-1 genotypic resistance testing (HIV genotyping) among laboratories to permit rigorous comparison of results from different clinics and testing centres. TAQAS has evaluated three panels of HIV-1-positive plasma from clinical material or low-passage, culture supernatant for up to 10 Asian laboratories. Laboratory participants used their standard protocols to perform HIV genotyping. Assessment was in comparison to a target genotype derived from all participants and the reference laboratory's result. Agreement between most participants at the edited nucleotide sequence level was high (>98%). Most participants performed to the reference laboratory standard in detection of drug resistance mutations (DRMs). However, there was variation in the detection of nucleotide mixtures (0-83%) and a significant correlation with the detection of DRMs (p<0.01). Interpretation of antiretroviral resistance showed approximately 70% agreement among participants when different interpretation systems were used but >90% agreement with a common interpretation system, within the Stanford University Drug Resistance Database. Using the principles of external quality assessment and a reference laboratory, TAQAS has demonstrated high quality HIV genotyping results from Asian laboratories.

  16. European Group for Blood and Marrow Transplantation Centers with FACT-JACIE Accreditation Have Significantly Better Compliance with Related Donor Care Standards.

    PubMed

    Anthias, Chloe; O'Donnell, Paul V; Kiefer, Deidre M; Yared, Jean; Norkin, Maxim; Anderlini, Paolo; Savani, Bipin N; Diaz, Miguel A; Bitan, Menachem; Halter, Joerg P; Logan, Brent R; Switzer, Galen E; Pulsipher, Michael A; Confer, Dennis L; Shaw, Bronwen E

    2016-03-01

    Previous studies have identified healthcare practices that may place undue pressure on related donors (RDs) of hematopoietic cell products and an increase in serious adverse events associated with morbidities in this population. As a result, specific requirements to safeguard RD health have been introduced to Foundation for the Accreditation of Cellular Therapy/The Joint Accreditation Committee ISCT and EBMT (FACT-JACIE) Standards, but the impact of accreditation on RD care has not previously been evaluated. A survey of transplant program directors of European Group for Blood and Marrow Transplantation member centers was conducted by the Donor Health and Safety Working Committee of the Center for International Blood and Marrow Transplant Research to test the hypothesis that RD care in FACT-JACIE accredited centers is more closely aligned with international consensus donor care recommendations than RD care delivered in centers without accreditation. Responses were received from 39% of 304 centers. Our results show that practice in accredited centers was much closer to recommended standards as compared with nonaccredited centers. Specifically, a higher percentage of accredited centers use eligibility criteria to assess RDs (93% versus 78%; P = .02), and a lower percentage have a single physician simultaneously responsible for an RD and their recipient (14% versus 35%; P = .008). In contrast, where regulatory standards do not exist, both accredited and nonaccredited centers fell short of accepted best practice. These results raise concerns that despite improvements in care, current practice can place undue pressure on donors and may increase the risk of donation-associated adverse events. We recommend measures to address these issues through enhancement of regulatory standards as well as national initiatives to standardize RD care.

  17. Fbis report. Science and technology: China. Broef introduction to the state key laboratories and engineering research centers established in universities of China, September 1, 1995

    SciTech Connect

    1995-09-01

    In order to enhance the quality and productivity of research in strategic areas relevant to long-term economic and social development and nurture a body of creative young scientists, the State Planning Commission (SPC) of the People`s Republic of China has established a number of State Key Laboratories (SKLs) in some universities and research institutes since 1984, equipped with advanced equipment and instruments for enhancing basic and applied research. This book contains an introduction to the 44 SEDC-supported SKLs, 57 SKLs which are funded by the key Studies Development Projects Loan from the World Bank, 52 research laboratories supported by the State Education Commission (SEDC) of the P.R. China, and the 14 National Engineering Research Centers (NERCs) supported by the SPC: Total 153 laboratories and 14 NERCs.

  18. Effect of new breakpoints proposed by Clinical and Laboratory Standards Institute in 2008 for evaluating penicillin resistance of Streptococcus pneumoniae in a Turkish University Hospital.

    PubMed

    Doğan, Ozlem; Gülmez, Dolunay; Hasçelik, Gülşen

    2010-03-01

    Clinical and Laboratory Standards Institute changed penicillin susceptibility breakpoints for Streptococcus pneumoniae in 2008. After reevaluation with new breakpoints, resistance rates decreased from 6.1% to 0.5% for nonmeningitis and increased from 6.6% to 33.3% for meningitis isolates in our hospital. This breakpoint modification is expected to reduce the inconsistency between susceptibility results and therapeutic outcomes; however, both the clinical microbiology laboratories and the clinicians should be aware of the change to interpret the susceptibility results.

  19. Guideline: the laboratory diagnosis of malaria. General Haematology Task Force of the British Committee for Standards in Haematology.

    PubMed

    Bailey, J Wendi; Williams, John; Bain, Barbara J; Parker-Williams, John; Chiodini, Peter L

    2013-12-01

    UK National External Quality Assessment Service surveys indicate continuing problems in malaria diagnosis: inaccurate calculation of parasitaemia or failure to estimate it altogether, difficulty distinguishing Plasmodium vivax from P. ovale, reporting malaria parasites when none were present and misidentification of P. falciparum as another species still occur. Therefore, the British Committee for Standards in Haematology Guidelines for the Laboratory Diagnosis of Malaria have been revised. They are intended for use in the UK but may also prove useful in other non-endemic areas. Routine use of thick and thin films is advised for malaria diagnosis. Thick films should be stained using Giemsa or Field stain. Thin films should be stained with Giemsa stain or Leishman stain. Thick films should be examined by two observers, each viewing a minimum of 200 high power fields. If thick films are positive, the species should be determined by examination of a thin film. In the case of P. falciparum or P. knowlesi infection, the percentage of parasitized cells or the number of parasites per microlitre (/μl) should be estimated and reported. Rapid diagnostic tests (RDTs) for malarial antigen cannot replace microscopy but are indicated as a supplementary test when malaria diagnosis is performed by relatively inexperienced staff. Malaria RDTs are negative in babesiosis.

  20. Laboratory diagnostic outcome applying detection criteria recommended by the Scientific and Standardization Committee of the ISTH on Lupus Anticoagulant.

    PubMed

    Chantarangkul, Veena; Biguzzi, Eugenia; Asti, Daniela; Palmucci, Claudia; Tripodi, Armando

    2013-07-01

    This study shows the diagnostic outcome of an APTT-based and two dRVVT-based commercial confirmatory integrated tests with the application of the recommendations by the Scientific and Standardization Committee (SSC) on Lupus anticoagulant (LA)/antiphospholipid syndrome (APS) of the International Society on Thrombosis and Haemostasis (ISTH) issued in 2009 concerning the cut-off values for the screening, mixing and confirmatory tests for the detection of LA and the mandatory need to perform mixing tests of patient plasma with pooled normal plasma. The study population included 565 patients collected from a large central coagulation laboratory, for which the attending physicians requested LA detection. One-hundred-six healthy subjects (HS) and 131 selected patients on oral anticoagulant therapy (OAT) were included as negative controls. The results suggest that the performance of mixing tests is indicated for those methods with relatively poor specificity, but is less needed for those methods with high specificity. Furthermore, the SSC recommendation to use normal mid-value (i.e. the 50th percentile of distribution of results from healthy subjects) as the cut-off to interpret results of confirmatory tests, showed a modest increase in LA detection rate (sensitivity) but at the expense of specificity, particularly in methods with low specificity.

  1. Non-matrix Matched Glass Disk Calibration Standards Improve XRF Micronutrient Analysis of Wheat Grain across Five Laboratories in India.

    PubMed

    Guild, Georgia E; Stangoulis, James C R

    2016-01-01

    Within the HarvestPlus program there are many collaborators currently using X-Ray Fluorescence (XRF) spectroscopy to measure Fe and Zn in their target crops. In India, five HarvestPlus wheat collaborators have laboratories that conduct this analysis and their throughput has increased significantly. The benefits of using XRF are its ease of use, minimal sample preparation and high throughput analysis. The lack of commercially available calibration standards has led to a need for alternative calibration arrangements for many of the instruments. Consequently, the majority of instruments have either been installed with an electronic transfer of an original grain calibration set developed by a preferred lab, or a locally supplied calibration. Unfortunately, neither of these methods has been entirely successful. The electronic transfer is unable to account for small variations between the instruments, whereas the use of a locally provided calibration set is heavily reliant on the accuracy of the reference analysis method, which is particularly difficult to achieve when analyzing low levels of micronutrient. Consequently, we have developed a calibration method that uses non-matrix matched glass disks. Here we present the validation of this method and show this calibration approach can improve the reproducibility and accuracy of whole grain wheat analysis on 5 different XRF instruments across the HarvestPlus breeding program.

  2. Non-matrix Matched Glass Disk Calibration Standards Improve XRF Micronutrient Analysis of Wheat Grain across Five Laboratories in India

    PubMed Central

    Guild, Georgia E.; Stangoulis, James C. R.

    2016-01-01

    Within the HarvestPlus program there are many collaborators currently using X-Ray Fluorescence (XRF) spectroscopy to measure Fe and Zn in their target crops. In India, five HarvestPlus wheat collaborators have laboratories that conduct this analysis and their throughput has increased significantly. The benefits of using XRF are its ease of use, minimal sample preparation and high throughput analysis. The lack of commercially available calibration standards has led to a need for alternative calibration arrangements for many of the instruments. Consequently, the majority of instruments have either been installed with an electronic transfer of an original grain calibration set developed by a preferred lab, or a locally supplied calibration. Unfortunately, neither of these methods has been entirely successful. The electronic transfer is unable to account for small variations between the instruments, whereas the use of a locally provided calibration set is heavily reliant on the accuracy of the reference analysis method, which is particularly difficult to achieve when analyzing low levels of micronutrient. Consequently, we have developed a calibration method that uses non-matrix matched glass disks. Here we present the validation of this method and show this calibration approach can improve the reproducibility and accuracy of whole grain wheat analysis on 5 different XRF instruments across the HarvestPlus breeding program. PMID:27375644

  3. Non-Contact Methods for Measuring Front Cavity Depths of Laboratory Standard Microphones Using a Depth-Measuring Microscope

    PubMed Central

    Nedzelnitsky, Victor; Wagner, Randall P.

    2008-01-01

    To achieve an acceptable degree of accuracy at high frequencies in some standardized methods for primary calibration of laboratory standard (LS) microphones, the front cavity depth lfc of each microphone must be known. This dimension must be measured using non-contact methods to prevent damage to the microphone diaphragm. The basic capabilities of an optical depth-measuring microscope were demonstrated by the agreement of its measurements within 0.7 μm of the known values of reference gage blocks. Using this microscope, two basic methods were applied to measure lfc. One (D) uses direct measurements at the microphone front surface annulus and conventional data reduction techniques. The other (GB) uses measurements at the surface of a gage block placed on the annulus, and plane-fitting data reduction techniques intended to reduce the effects of the slightly imperfect geometries of the microphones. The GB method was developed to provide a smoother surface of measurement than the relatively rough surface of the annulus, and to simulate the contact that occurs between the annulus and the smooth, plane surface of an acoustic coupler during microphone calibration. Using these methods, full data sets were obtained at 33 measurement positions (D), or 25 positions (GB). In addition, D and GB subsampling methods were applied by using subsamples of either the D or the GB full data sets. All these methods were applied to six LS microphones, three each of two different types. The GB subsampling methods are preferred for several reasons. The measurement results for lfc obtained by these methods agree well with those obtained by the GB method using the full data set. The expanded uncertainties of results from the GB subsampling methods are not very different from the expanded uncertainty of results from the GB method using the full data set, and are smaller than the expanded uncertainties of results from the D subsampling methods. Measurements of lfc using the GB subsampling

  4. 42 CFR 493.1773 - Standard: Basic inspection requirements for all laboratories issued a CLIA certificate and CLIA...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... issued a certificate must permit CMS or a CMS agent to conduct an inspection to assess the laboratory's... procedures. (2) Permit interviews of all personnel concerning the laboratory's compliance with the applicable requirements of this part. (3) Permit laboratory personnel to be observed performing all phases of the...

  5. 42 CFR 493.1773 - Standard: Basic inspection requirements for all laboratories issued a CLIA certificate and CLIA...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... issued a certificate must permit CMS or a CMS agent to conduct an inspection to assess the laboratory's... procedures. (2) Permit interviews of all personnel concerning the laboratory's compliance with the applicable requirements of this part. (3) Permit laboratory personnel to be observed performing all phases of the...

  6. 42 CFR 493.1773 - Standard: Basic inspection requirements for all laboratories issued a CLIA certificate and CLIA...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... issued a certificate must permit CMS or a CMS agent to conduct an inspection to assess the laboratory's... procedures. (2) Permit interviews of all personnel concerning the laboratory's compliance with the applicable requirements of this part. (3) Permit laboratory personnel to be observed performing all phases of the...

  7. Practical solution for control of the pre-analytical phase in decentralized clinical laboratories for meeting the requirements of the medical laboratory accreditation standard DIN EN ISO 15189.

    PubMed

    Vacata, Vladimir; Jahns-Streubel, Gerlinde; Baldus, Mirjana; Wood, William Graham

    2007-01-01

    This report was written in response to the article by Wood published recently in this journal. It describes a practical solution to the problems of controlling the pre-analytical phase in the clinical diagnostic laboratory. As an indicator of quality in the pre-analytical phase of sample processing, a target analyte was chosen which is sensitive to delay in centrifugation and/or analysis. The results of analyses of the samples sent by satellite medical practitioners were compared with those from an on-site hospital laboratory with a controllable optimized pre-analytical phase. The aim of the comparison was: (a) to identify those medical practices whose mean/median sample values significantly deviate from those of the control situation in the hospital laboratory due to the possible problems in the pre-analytical phase; (b) to aid these laboratories in the process of rectifying these problems. A Microsoft Excel-based Pre-Analytical Survey tool (PAS tool) has been developed which addresses the above mentioned problems. It has been tested on serum potassium which is known to be sensitive to delay and/or irregularities in sample treatment. The PAS tool has been shown to be one possibility for improving the quality of the analyses by identifying the sources of problems within the pre-analytical phase, thus allowing them to be rectified. Additionally, the PAS tool has an educational value and can also be adopted for use in other decentralized laboratories.

  8. The US radiation dosimetry standards for 60Co therapy level beams, and the transfer to the AAPM accredited dosimetry calibration laboratories.

    PubMed

    Minniti, R; Chen-Mayer, H; Seltzer, S M; Huq, M Saiful; Bryson, L; Slowey, T; Micka, J A; DeWerd, L A; Wells, N; Hanson, W F; Ibbott, G S

    2006-04-01

    This work reports the transfer of the primary standard for air kerma from the National Institute of Standards and Technology (NIST) to the secondary laboratories accredited by the American Association of Physics in Medicine (AAPM). This transfer, performed in August of 2003, was motivated by the recent revision of the NIST air-kerma standards for 60Co gamma-ray beams implemented on July 1, 2003. The revision involved a complete recharacterization of the two NIST therapy-level 60Co gamma-ray beam facilities, resulting in new values for the air-kerma rates disseminated by the NIST. Some of the experimental aspects of the determination of the new air-kerma rates are briefly summarized here; the theoretical aspects have been described in detail by Seltzer and Bergstrom ["Changes in the U.S. primary standards for the air-kerma from gamma-ray beams," J. Res. Natl. Inst. Stand. Technol. 108, 359-381 (2003)]. The standard was transferred to reference-class chambers submitted by each of the AAPM Accredited Dosimetry Calibration Laboratories (ADCLs). These secondary-standard instruments were then used to characterize the 60Co gamma-ray beams at the ADCLs. The values of the response (calibration coefficient) of the ADCL secondary-standard ionization chambers are reported and compared to values obtained prior to the change in the NIST air-kerma standards announced on July 1, 2003. The relative change is about 1.1% for all of these chambers, and this value agrees well with the expected change in chambers calibrated at the NIST or at any secondary-standard laboratory traceable to the new NIST standard.

  9. Idea-Centered Laboratory Science (I-CLS), [Unit] C, How a Scientist Expects His World To Behave.

    ERIC Educational Resources Information Center

    Van Deventer, William C.; Duyser, Lucille

    The major ideas of this unit are: consistency and uniformity, cause and effect, and parsimony. Laboratory experiences consist of investigations into: projecting expectations, moon and stars, the relationships among different kinds of change (daily, monthly, annual temperature changes), force and motion, chemical reactions, superstitions, origin of…

  10. A Student-Centered First-Semester Introductory Organic Laboratory Curriculum Facilitated by Microwave-Assisted Synthesis (MAOS)

    ERIC Educational Resources Information Center

    Russell, Cianán B.; Mason, Jeremy D.; Bean, Theodore G.; Murphree, S. Shaun

    2014-01-01

    An instructional laboratory curriculum for a first-semester introductory organic chemistry course has been developed using microwave-assisted organic synthesis (MAOS). Taking advantage of short reaction times, materials were developed to facilitate collaborative experimental design, analysis, and debriefing of results during the normal laboratory…

  11. Improved standardization and potential for shortened time to results with BD Kiestra™ total laboratory automation of early urine cultures: A prospective comparison with manual processing.

    PubMed

    Graham, Maryza; Tilson, Leanne; Streitberg, Richard; Hamblin, John; Korman, Tony M

    2016-09-01

    We compared the results of 505 urine specimens prospectively processed by both conventional manual processing (MP) with 16-24h incubation to BD Kiestra™ Total Laboratory Automation (TLA) system with a shortened incubation of 14h: 97% of culture results were clinically concordant. TLA processing was associated with improved standardization of time of first culture reading and total incubation time.

  12. Validation of 24-hour flucytosine MIC determination by comparison with 48-hour determination by the Clinical and Laboratory Standards Institute M27-A3 broth microdilution reference method.

    PubMed

    Lockhart, Shawn R; Bolden, Carol B; Iqbal, Naureen; Kuykendall, Randall J

    2011-12-01

    Flucytosine and itraconazole are the only antifungal agents for which the Clinical Laboratory and Standards Institute recommendations include MIC breakpoint readings at 48 h only. Here we show good essential and categorical agreement between the flucytosine MIC readings at 48 and 24 h for Candida species.

  13. Evaluation of Clinical Laboratory Standards Institute interpretive criteria for methicillin-resistant Staphylococcus pseudintermedius isolated from dogs.

    PubMed

    Schissler, Jennifer R; Hillier, Andrew; Daniels, Joshua B; Cole, Lynette K; Gebreyes, Wondwossen A

    2009-09-01

    The Clinical and Laboratory Standards Institute published in 2008 new interpretive criteria for the identification of methicillin resistance in staphylococci isolated from animals. The sensitivity of the 2008 interpretive criteria for mecA gene-positive Staphylococcus pseudintermedius, compared with the previous criteria of 2004, was investigated. Thirty clinical isolates of methicillin-resistant S. pseudintermedius from dogs were used. The presence of the mecA gene was determined by polymerase chain reaction. The minimum inhibitory concentration for oxacillin was determined by broth microdilution. The 2008 breakpoint of >or=4 microg/ml for methicillin resistance resulted in a diagnostic sensitivity of 73.3% (22/30). The 2004 breakpoint guideline of >or=0.5 microg/ml resulted in a diagnostic sensitivity of 97% (29/30). For oxacillin disk diffusion, the 2008 interpretive criterion of

  14. Enhanced cell affinity of chitosan membranes mediated by superficial cross-linking: a straightforward method attainable by standard laboratory procedures.

    PubMed

    Rodríguez-Velázquez, Eustolia; Silva, Maite; Taboada, Pablo; Mano, João F; Suárez-Quintanilla, David; Alatorre-Meda, Manuel

    2014-01-13

    It is well accepted that the surface modification of biomaterials can improve their biocompatibility. In this context, techniques like ion etching, plasma-mediated chemical functionalization, electrospinning, and contact microprinting have successfully been employed to promote the cell adhesion and proliferation of chitosan (CH) substrates. However, they prove to be time-consuming, highly dependent on environmental conditions, and/or limited to the use of expensive materials and sophisticated instruments not accessible to standard laboratories, hindering to a high extent their straightforward application. Filling this gap, this paper proposes the superficial cross-linking of CH as a much simpler and accessible means to modify its superficial properties in order to enhance its cellular affinity. CH membranes were prepared by solvent casting followed by a cross-linking step mediated by the chemical vapor deposition (CVD) of glutaraldehyde (GA). The membranes were characterized against non- and solution cross-linked membranes in terms of their mechanical/surface properties and biological performance. Among others, the CVD membranes proved (i) to be more mechanically stable against cell culture and sterilization than membranes cross-linked in solution and (ii) to prompt the adherence and sustained proliferation of healthy cells to levels even superior to commercial tissue culture plates (TCPs). Accordingly, the CVD cross-linking approach was demonstrated to be a simple and cost-effective alternative to the aforementioned conventional methods. Interestingly, this concept can also be applied to other biomaterials as long as GA (or other volatile components alike) can be employed as a cross-linker, making possible the cross-linking reaction at mild experimental conditions, neither requiring sophisticated lab implements nor using any potentially harmful procedure.

  15. The Newborn Screening Quality Assurance Program at the Centers for Disease Control and Prevention: Thirty-five Year Experience Assuring Newborn Screening Laboratory Quality.

    PubMed

    De Jesús, Víctor R; Mei, Joanne V; Cordovado, Suzanne K; Cuthbert, Carla D

    Newborn screening is the largest genetic testing effort in the United States and is considered one of the ten great public health achievements during the first 10 years of the 21(st) century. For over 35 years, the Newborn Screening Quality Assurance Program (NSQAP) at the US Centers for Disease Control and Prevention has helped NBS laboratories ensure that their testing does not delay diagnosis, minimizes false-positive reports, and sustains high-quality testing performance. It is a multi-component program that provides comprehensive quality assurance services for dried blood spot testing. The NSQAP, the Biochemical Mass Spectrometry Laboratory (BMSL), the Molecular Quality Improvement Program (MQIP) and the Newborn Screening Translation Research Initiative (NSTRI), aid screening laboratories achieve technical proficiency and maintain confidence in their performance while processing large volumes of specimens daily. The accuracy of screening tests could be the difference between life and death for many babies; in other instances, identifying newborns with a disorder means that they can be treated and thus avoid life-long disability or severe cognitive impairment. Thousands of newborns and their families have benefited from reliable and accurate testing that has been accomplished by a network of screening laboratories and the NSQAP, BMSL, MQIP and NSTRI.

  16. Comparative Effectiveness of Standard versus Patient-Centered Collaborative Care Interventions for Depression among African Americans in Primary Care Settings: The BRIDGE Study

    PubMed Central

    Cooper, Lisa A; Ghods Dinoso, Bri K; Ford, Daniel E; Roter, Debra L; Primm, Annelle B; Larson, Susan M; Gill, James M; Noronha, Gary J; Shaya, Elias K; Wang, Nae-Yuh

    2013-01-01

    Objective To compare the effectiveness of standard and patient-centered, culturally tailored collaborative care (CC) interventions for African American patients with major depressive disorder (MDD) over 12 months of follow-up. Data Sources/Study Setting Twenty-seven primary care clinicians and 132 African American patients with MDD in urban community-based practices in Maryland and Delaware. Study Design Cluster randomized trial with patient-level, intent-to-treat analyses. Data Collection/Extraction Methods Patients completed screener and baseline, 6-, 12-, and 18-month interviews to assess depression severity, mental health functioning, health service utilization, and patient ratings of care. Principal Findings Patients in both interventions showed statistically significant improvements over 12 months. Compared with standard, patient-centered CC patients had similar reductions in depression symptom levels (−2.41 points; 95 percent confidence interval (CI), −7.7, 2.9), improvement in mental health functioning scores (+3.0 points; 95 percent CI, −2.2, 8.3), and odds of rating their clinician as participatory (OR, 1.48, 95 percent CI, 0.53, 4.17). Treatment rates increased among standard (OR = 1.8, 95 percent CI 1.0, 3.2), but not patient-centered (OR = 1.0, 95 percent CI 0.6, 1.8) CC patients. However, patient-centered CC patients rated their care manager as more helpful at identifying their concerns (OR, 3.00; 95 percent CI, 1.23, 7.30) and helping them adhere to treatment (OR, 2.60; 95 percent CI, 1.11, 6.08). Conclusions Patient-centered and standard CC approaches to depression care showed similar improvements in clinical outcomes for African Americans with depression; standard CC resulted in higher rates of treatment, and patient-centered CC resulted in better ratings of care. PMID:22716199

  17. 42 CFR 493.1441 - Condition: Laboratories performing high complexity testing; laboratory director.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Condition: Laboratories performing high complexity testing; laboratory director. 493.1441 Section 493.1441 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION...

  18. 42 CFR 493.1441 - Condition: Laboratories performing high complexity testing; laboratory director.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false Condition: Laboratories performing high complexity testing; laboratory director. 493.1441 Section 493.1441 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION...

  19. 42 CFR 493.1441 - Condition: Laboratories performing high complexity testing; laboratory director.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Condition: Laboratories performing high complexity testing; laboratory director. 493.1441 Section 493.1441 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION...

  20. 42 CFR 493.1441 - Condition: Laboratories performing high complexity testing; laboratory director.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Condition: Laboratories performing high complexity testing; laboratory director. 493.1441 Section 493.1441 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION...

  1. COMBINED MEASUREMENTS WITH THREE-DIMENSIONAL DESIGN INFORMATION VERIFICATION SYSTEM AND GAMMA RAY IMAGING - A COLLABORATIVE EFFORT BETWEEN OAK RIDGE NATIONAL LABORATORY, LAWRENCE LIVERMORE NATIONAL LABORATORY, AND THE JOINT RESEARCH CENTER AT ISPRA

    SciTech Connect

    Mihailescu, L; Vetter, K; Ruhter, W; Chivers, D; Dreicer, M; Coates, C; Smith, S; Hines, J; Caiado, A R; Sequeira, V; Fiocco, M; Goncalves, J G

    2006-06-14

    Oak Ridge National Laboratory (ORNL) and Lawrence Livermore National Laboratory (LLNL) have jointly performed tests to demonstrate combined measurements with a three-dimensional (3D) design information verification (DIV) system and a gamma-ray imager for potential safeguard applications. The 3D DIV system was made available by the European Commission's Joint Research Center to ORNL under a collaborative project between the U.S. Department of Energy and the European Atomic Energy Community (EURATOM). The system is able to create 3D maps of rooms and objects and of identifying changes in positions and modifications with a precision on the order of millimeters. The gamma ray imaging system consists of a 4{pi} field-of-view Compton imaging system which has two fully operational DSSD (Double-Sided Segment Detector) High-Purity Germanium (HPGe) detectors developed at LLNL. The Compton imaging instrument not only provides imaging capabilities, but provides excellent energy resolution which enables the identification of radioisotopes and nuclear materials. Joint Research Center was responsible to merge gamma-ray images with the 3D range maps. The results of preliminary first measurements performed at LLNL demonstrate, for the first time, mapping of panoramic gamma-ray images into 3D range data.

  2. Investigations of Standard Model and Exotic Monophoton Signatures at Center of Mass Energy = 7 TeV

    NASA Astrophysics Data System (ADS)

    Miceli, Tia Marie

    This dissertation describes the search for large extra dimensions. Such extra dimensions could solve the hierarchy problem, one of the greatest puzzles in the field of particle physics. The hierarchy problem is the mystery of why gravity is significantly weaker than the electromagnetic, strong, and weak forces. A solution would unify the strength of gravity with the strength of the other forces. There are many possible tests for extra dimensions. Presented is the analysis of proton-proton collisions with final states in which a single photon recoils from an invisible particle. These data were collected with the Compact Muon Solenoid detector during the 2011 Large Hadron Collider run at CERN, in Geneva, Switzerland, and correspond to an integrated luminosity of 5 fb-1 of proton-proton collisions at a center of mass energy of 7 TeV. Backgrounds are estimated using data driven techniques for those due to W → nue, hadronic jets, and non-collision backgrounds such as beam remnants faking a photon, and anomalous energy deposits in the electromagnetic calorimeter. The less significant backgrounds are estimated using Monte Carlo simulation, Wgamma, dijet, and jet + gamma. The irreducible Z(nunu)+ gamma background was estimated in Monte Carlo for the extra dimension search, but in later studies this component should be estimated by using a ratio of the measured Zgamma → mumugamma cross section. The results are consistent with the predicted Standard Model cross section of Z bosons decaying to neutrino pairs. Subsequently, the worlds best limits are placed on the monophoton topology of large extra dimensions. The same analysis provides a measurement of the Z(nunu)+gamma cross section consistent with next to leading order predictions.

  3. An inter-laboratory comparison study of the ANSI/BIFMA standard test method M7.1 for furniture

    EPA Science Inventory

    Five laboratories using five different test chambers participated in the study to quantify within- and between-laboratory variability in the measurement of emissions of volatile organic compounds (VOCs) from new commercial furniture test items following ANSI/BIFMA M7.1. Test item...

  4. Curriculum Based Functional Vocational Assessment Guide. Correlation of the Life Centered Career Education Curriculum with Specific Occupational Programs, Standards of Work Performance, and Campus Assessment Instruments.

    ERIC Educational Resources Information Center

    Quinones, William A.

    This document is a guide developed for the Dallas Independent School District's (DISD's) Multiple Careers Magnet Center, which provides special education students with training in standards of work performance and specific occupational skills for successful transition to community life and employment. The document also provides information for…

  5. National Crime Information Center Mandatory Minimum Standards Curriculum for Full Access Terminal Operators. Volume One--Administrative Issues, Policy and the Interstate Identification Index.

    ERIC Educational Resources Information Center

    Federal Bureau of Investigation, Washington, DC. National Crime Information Center.

    This document is the first volume of a two-volume set of lesson plans which together make up a complete training package for full-service terminal operators. The lesson plans are designed to ensure that a state's National Crime Information Center (NCIC) training program meets Advisory Policy Board standards. (NCIC is a nationwide computerized…

  6. Hormones and Antibiotics in Nature: A Laboratory Module Designed to Broaden Undergraduate Perspectives on Typically Human-Centered Topics†

    PubMed Central

    Weber, Carolyn F.

    2014-01-01

    Bringing discovery-based research into undergraduate laboratory courses increases student motivation and learning gains over traditional exercises that merely teach technique or demonstrate well-documented phenomena. Laboratory experiences are further enhanced when they are designed to challenge student perspectives on topics relevant to their lives. To this end, a laboratory module on antibiotics and hormones, which are generally discussed in the context of human health, was developed for students to explore the multifaceted roles of antibiotics and hormones in nature (e.g. interspecies communication) via reading primary scientific literature and performing discovery-based experiments. The main objective of this module was to increase the general biological literacy of students as determined by their ability to connect the Five Core Concepts of Biological Literacy (American Association for the Advancement of Science, Vision and Change in Undergraduate Education: A Call to Action, 2011) to the topics “hormones” and “antibiotics” in pre- and postmodule surveys. After discussing unpublished research findings, cell biology students performed experiments demonstrating that: 1) fungi may promote fern growth via hormone production, 2) novel bacterial isolates in the genus Streptomyces produce antifungal compounds, and 3) subinhibitory antibiotic concentrations may enhance soil bacterial growth. The third finding provided evidence supporting a hypothesis framed in a scientific article that students read and discussed. Student perspectives on premodule surveys focused on roles of hormones and antibiotics in the human body (e.g. development, fighting infection), but their broadened postmodule perspectives encompassed the roles of these molecules in organismal communication and possibly the evolution of multicellularity. PMID:25574294

  7. Hormones and antibiotics in nature: a laboratory module designed to broaden undergraduate perspectives on typically human-centered topics.

    PubMed

    Weber, Carolyn F

    2014-12-01

    Bringing discovery-based research into undergraduate laboratory courses increases student motivation and learning gains over traditional exercises that merely teach technique or demonstrate well-documented phenomena. Laboratory experiences are further enhanced when they are designed to challenge student perspectives on topics relevant to their lives. To this end, a laboratory module on antibiotics and hormones, which are generally discussed in the context of human health, was developed for students to explore the multifaceted roles of antibiotics and hormones in nature (e.g. interspecies communication) via reading primary scientific literature and performing discovery-based experiments. The main objective of this module was to increase the general biological literacy of students as determined by their ability to connect the Five Core Concepts of Biological Literacy (American Association for the Advancement of Science, Vision and Change in Undergraduate Education: A Call to Action, 2011) to the topics "hormones" and "antibiotics" in pre- and postmodule surveys. After discussing unpublished research findings, cell biology students performed experiments demonstrating that: 1) fungi may promote fern growth via hormone production, 2) novel bacterial isolates in the genus Streptomyces produce antifungal compounds, and 3) subinhibitory antibiotic concentrations may enhance soil bacterial growth. The third finding provided evidence supporting a hypothesis framed in a scientific article that students read and discussed. Student perspectives on premodule surveys focused on roles of hormones and antibiotics in the human body (e.g. development, fighting infection), but their broadened postmodule perspectives encompassed the roles of these molecules in organismal communication and possibly the evolution of multicellularity.

  8. The Application of the Human Engineering Modeling and Performance Laboratory for Space Vehicle Ground Processing Tasks at Kennedy Space Center

    NASA Technical Reports Server (NTRS)

    Woodbury, Sarah K.

    2008-01-01

    The introduction of United Space Alliance's Human Engineering Modeling and Performance Laboratory began in early 2007 in an attempt to address the problematic workspace design issues that the Space Shuttle has imposed on technicians performing maintenance and inspection operations. The Space Shuttle was not expected to require the extensive maintenance it undergoes between flights. As a result, extensive, costly resources have been expended on workarounds and modifications to accommodate ground processing personnel. Consideration of basic human factors principles for design of maintenance is essential during the design phase of future space vehicles, facilities, and equipment. Simulation will be needed to test and validate designs before implementation.

  9. International, multi-center standardization of acute graft-versus-host disease clinical data collection: a report from the MAGIC consortium

    PubMed Central

    Harris, Andrew C.; Young, Rachel; Devine, Steven; Hogan, William J.; Ayuk, Francis; Bunworasate, Udomsak; Chanswangphuwana, Chantiya; Efebera, Yvonne A.; Holler, Ernst; Litzow, Mark; Ordemann, Rainer; Qayed, Muna; Renteria, Anne S.; Reshef, Ran; Wölfl, Matthias; Chen, Yi-Bin; Goldstein, Steven; Jagasia, Madan; Locatelli, Franco; Mielke, Stephan; Porter, David; Schechter, Tal; Shekhovtsova, Zhanna; Ferrara, James L.M.; Levine, John E.

    2015-01-01

    Acute graft-versus-host disease (GVHD) remains a leading cause of morbidity and non-relapse mortality following allogeneic hematopoietic cell transplantation. The clinical staging of GVHD varies greatly between transplant centers and is frequently not agreed upon by independent reviewers. The lack of standardized approaches to handle common sources of discrepancy in GVHD grading likely contributes to why promising GVHD treatments reported from single centers have failed to show benefit in randomized multi-center clinical trials. We developed guidelines through international expert consensus opinion to standardize the diagnosis and clinical staging of GVHD for use in a large international GVHD research consortium. During the first year of use, the guidance was following discussion of complex clinical phenotypes by experienced transplant physicians and data managers. These guidelines increase the uniformity of GVHD symptom capture which may improve the reproducibility of GVHD clinical trials after further prospective validation. PMID:26386318

  10. ETV Program Report: Coatings for Wastewater Collection Systems - Standard Cement Materials, Epoxy Coating 4553

    EPA Science Inventory

    The Standard Cement Materials, Inc. Standard Epoxy Coating 4553™ (SEC 4553) epoxy coating used for wastewater collection system rehabilitation was evaluated by EPA’s Environmental Technology Verification Program under laboratory conditions at the Center for Innovative Grouting Ma...

  11. The Center for Technology for Advanced Scientific Component Software (TASCS) Lawrence Livermore National Laboratory - Site Status Update

    SciTech Connect

    Epperly, T W

    2008-12-03

    This report summarizes LLNL's progress for the period April through September of 2008 for the Center for Technology for Advanced Scientific Component Software (TASCS) SciDAC. The TASCS project is organized into four major thrust areas: CCA Environment (72%), Component Technology Initiatives (16%), CCA Toolkit (8%), and User and Application Outreach & Support (4%). The percentage of LLNL's effort allocation is shown in parenthesis for each thrust area. Major thrust areas are further broken down into activity areas, LLNL's effort directed to each activity is shown in Figure 1. Enhancements, Core Tools, and Usability are all part of CCA Environment, and Software Quality is part of Component Technology Initiatives. The balance of this report will cover our accomplishments in each of these activity areas.

  12. [Epidemiological, clinical, cytologic and immunophenotypic aspects of acute leukemia in children: the experience at the hematology laboratory of IBN SINA University Hospital Center].

    PubMed

    Doumbia, Mariam; Uwingabiye, Jean; Bissan, Aboubacar; Rachid, Razine; Benkirane, Souad; Masrar, Azlarab

    2016-01-01

    The aim of this study was to describe epidemiological, cytologic and immunophenotypic aspects of acute leukemias (AL) in children diagnosed at IBN SINA University Hospital Center and to determine the concordance between cytology and immunophenotyping results. This is a cross-sectional study conducted in the hematology laboratory of IBN SINA University Hospital Center between June 2012 and May 2014. Among the 104 cases with diagnosed AL, 52% were boys with a sex-ratio H/F= 1.32, the average age was 5.7 years. The distribution of different types of AL was: lymphoid AL (LAL) (74%), myeloid (AML) (20.2%), biphenotypic AL (BAL) (65.8%). Among the LALs, 78% were classified as B LAL and 22% as T LAL. Clinical signs were mainly presented with tumor syndrome (73.1%), fever (61%) and hemorrhagic syndrome (50%). The most common blood count abnormalities were: thrombopenia (89.4%), anemia (86.5%), hyperleukocytosis (79.8%). The rate of peripheral and bone marrow blasts was statistically higher for LAL than for AML and BAL (p <0.001). The rate of relapse and mortality was 21.2% and 16. 3% respectively. Concordance rate between the results of cytology and of immunophenotyping was 92.7% for LAL and 82.6% for AML. Diagnosis of AL is always based primarily on cytology. Immunophenotyping allowed us to make a better distinction between acute leukemias. The management of paediatric AL is a major health problem which requires specialized care centers.

  13. Epidemiology of Clostridium difficile in Germany based on a single center long-term surveillance and German-wide genotyping of recent isolates provided to the advisory laboratory for diagnostic reasons.

    PubMed

    von Müller, Lutz; Mock, Markus; Halfmann, Alexander; Stahlmann, Julia; Simon, Arne; Herrmann, Mathias

    2015-10-01

    Epidemiology of Clostridium difficile is characterized by worldwide increase of C. difficile infections (CDI) and the emergence of new epidemic outbreak strains with the capacity for global spreading. Long-term local surveillance at the University of Saarland Medical Center between 2000 and 2013 shows that the incidence rate of laboratory-confirmed CDI was influenced by local epidemiology as well as by testing strategies. Since 2008, molecular typing of C. difficile was regularly performed for symptomatic hospitalized patients by surface-layer protein A sequence typing (slpAST), which is an established highly standardized technique for genotyping of C. difficile. The results were assigned to known ribotypes for better comparison to international data. It could be demonstrated that distribution of genotypes was different between age groups. Older patients were predominantly infected with ribotype 001 and 027, whereas ribotype 027 was not detected in the pediatric population. Molecular typing of German isolates sent to the advisory laboratory between 2011 and 2013 revealed that ribotype 027 is present with high percentages in most German regions except for the very North. In conclusion, optimized testing of all hospitalized patients with diarrhea should be generally implemented to avoid under-diagnosis of C. difficile infection. Ribotype 027 is highly prevalent in Germany, but its infections are restricted to older patients, while absent in children. Molecular typing of suspected hospital outbreaks and of patients with severe or recurrent disease may help to better understand virulence and epidemic spreading of C. difficile.

  14. Establishment and validation of a standard protocol for the detection of minimal residual disease in B lineage childhood acute lymphoblastic leukemia by flow cytometry in a multi-center setting.

    PubMed

    Irving, Julie; Jesson, Jenny; Virgo, Paul; Case, Marian; Minto, Lynne; Eyre, Lisa; Noel, Nigel; Johansson, Ulrika; Macey, Marion; Knotts, Linda; Helliwell, Margaret; Davies, Paul; Whitby, Liam; Barnett, David; Hancock, Jeremy; Goulden, Nick; Lawson, Sarah

    2009-06-01

    Minimal residual disease detection, used for clinical management of children with acute lymphoblastic leukemia, can be performed by molecular analysis of antigen-receptor gene rearrangements or by flow cytometric analysis of aberrant immunophenotypes. For flow minimal residual disease to be incorporated into larger national and international trials, a quality assured, standardized method is needed which can be performed in a multi-center setting. We report a four color, flow cytometric protocol established and validated by the UK acute lymphoblastic leukemia Flow minimal residual disease group. Quality assurance testing gave high inter-laboratory agreement with no values differing from a median consensus value by more than one point on a logarithmic scale. Prospective screening of B-ALL patients (n=206) showed the method was applicable to 88.3% of patients. The minimal residual disease in bone marrow aspirates was quantified and compared to molecular data. The combined risk category concordance (minimal residual disease levels above or below 0.01%) was 86% (n=134). Thus, this standardized protocol is highly reproducible between laboratories, sensitive, applicable, and shows good concordance with molecular-based analysis.

  15. Establishment and validation of a standard protocol for the detection of minimal residual disease in B lineage childhood acute lymphoblastic leukemia by flow cytometry in a multi-center setting;

    PubMed Central

    Irving, Julie; Jesson, Jenny; Virgo, Paul; Case, Marian; Minto, Lynne; Eyre, Lisa; Noel, Nigel; Johansson, Ulrika; Macey, Marion; Knotts, Linda; Helliwell, Margaret; Davies, Paul; Whitby, Liam; Barnett, David; Hancock, Jeremy; Goulden, Nick; Lawson, Sarah

    2009-01-01

    Minimal residual disease detection, used for clinical management of children with acute lymphoblastic leukemia, can be performed by molecular analysis of antigen-receptor gene rearrangements or by flow cytometric analysis of aberrant immunophenotypes. For flow minimal residual disease to be incorporated into larger national and international trials, a quality assured, standardized method is needed which can be performed in a multi-center setting. We report a four color, flow cytometric protocol established and validated by the UK acute lymphoblastic leukemia Flow minimal residual disease group. Quality assurance testing gave high inter-laboratory agreement with no values differing from a median consensus value by more than one point on a logarithmic scale. Prospective screening of B-ALL patients (n=206) showed the method was applicable to 88.3% of patients. The minimal residual disease in bone marrow aspirates was quantified and compared to molecular data. The combined risk category concordance (minimal residual disease levels above or below 0.01%) was 86% (n=134). Thus, this standardized protocol is highly reproducible between laboratories, sensitive, applicable, and shows good concordance with molecular-based analysis. PMID:19377076

  16. Calculation of Transactinide Homolog Isotope Production Reactions Possible with the Center for Accelerator Mass Spectrometry (CAMS) at Lawrence Livermore National Laboratory

    SciTech Connect

    Moody, K J; Shaughnessy, D A; Gostic, J M

    2011-11-29

    The LLNL heavy element group has been investigating the chemical properties of the heaviest elements over the past several years. The properties of the transactinides (elements with Z > 103) are often unknown due to their low production rates and short half-lives, which require lengthy cyclotron irradiations in order to make enough atoms for statistically significant evaluations of their chemistry. In addition, automated chemical methods are often required to perform consistent and rapid chemical separations on the order of minutes for the duration of the experiment, which can last from weeks to months. Separation methods can include extraction chromatography, liquid-liquid extraction, or gas-phase chromatography. Before a lengthy transactinide experiment can be performed at an accelerator, a large amount of preparatory work must be done both to ensure the successful application of the chosen chemical system to the transactinide chemistry problem being addressed, and to evaluate the behavior of the lighter elemental homologs in the same chemical system. Since transactinide chemistry is literally performed on one single atom, its chemical properties cannot be determined from bulk chemical matrices, but instead must be inferred from the behavior of the lighter elements that occur in its chemical group and in those of its neighboring elements. By first studying the lighter group homologs in a particular chemical system, when the same system is applied to the transactinide element under investigation, its decay properties can be directly compared to those of the homologues, thereby allowing an inference of its own chemistry. The Center for Accelerator Mass Spectrometry (CAMS) at Lawrence Livermore National Laboratory (LLNL) includes a 1 MV Tandem accelerator, capable of accelerating light ions such as protons to energies of roughly 15 MeV. By using the CAMS beamline, tracers of transactinide homolog elements can be produced both for development of chemical systems and

  17. PROCEEDINGS OF RIKEN BNL RESEARCH CENTER WORKSHOP, HADRON STRUCTURE FROM LATTICE QCD, MARCH 18 - 22, 2002, BROOKHAVEN NATIONAL LABORATORY.

    SciTech Connect

    BLUM, T.; BOER, D.; CREUTZ, M.; OHTA, S.; ORGINOS, K.

    2002-03-18

    The RIKEN BNL Research Center workshop on ''Hadron Structure from Lattice QCD'' was held at BNL during March 11-15, 2002. Hadron structure has been the subject of many theoretical and experimental investigations, with significant success in understanding the building blocks of matter. The nonperturbative nature of QCD, however, has always been an obstacle to deepening our understanding of hadronic physics. Lattice QCD provides the tool to overcome these difficulties and hence a link can be established between the fundamental theory of QCD and hadron phenomenology. Due to the steady progress in improving lattice calculations over the years, comparison with experimentally measured hadronic quantities has become important. In this respect the workshop was especially timely. By providing an opportunity for experts from the lattice and hadron structure communities to present their latest results, the workshop enhanced the exchange of knowledge and ideas. With a total of 32 registered participants and 26 talks, the interest of a growing community is clearly exemplified. At the workshop Schierholz and Negele presented the current status of lattice computations of hadron structure. Substantial progress has been made during recent years now that the quenched results are well under control and the first dynamical results have appeared. In both the dynamical and the quenched simulations the lattice results, extrapolated to lighter quark masses, seem to disagree with experiment. Melnitchouk presented a possible explanation (chiral logs) for this disagreement. It became clear from these discussions that lattice computations at significantly lighter quark masses need to be performed.

  18. Standardization of collection requirements for fasting samples: for the Working Group on Preanalytical Phase (WG-PA) of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM).

    PubMed

    Simundic, A M; Cornes, M; Grankvist, K; Lippi, G; Nybo, M

    2014-05-15

    Standardized protocols for patient preparation for laboratory testing are currently lacking. Moreover, a great heterogeneity exists in the definitions of "fasting" currently being used among healthcare workers and in the literature. Marked metabolic and hormonal changes occur after food ingestion, mainly due to the absorption of fluids, lipids, proteins, carbohydrates and other food constituents. This postprandial response varies markedly in response to numerous factors, such as eating behavior, food composition, fasting duration, time of the day, chronic and acute smoking, coffee and alcohol consumption. It is therefore crucial to minimize the total variability by controlling as many of these modifying factors as possible. Control of the abovementioned effects on postprandial response can only be achieved by standardizing the way patients are prepared for laboratory testing, i.e. by defining the fasting duration, as well as what is and what is not allowed (e.g., coffee, tea, smoking, water) during the period of fasting prior to sample collection. The aim of this article is to describe the range of effects of different approaches to fasting on laboratory tests, and to provide a framework for the harmonization of definitions for fasting requirements for laboratory tests.

  19. American College of Medical Genetics and Genomics Standards and Guidelines for Clinical Genetics Laboratories, 2014 edition: technical standards and guidelines for Huntington disease.

    PubMed

    Bean, Lora; Bayrak-Toydemir, Pinar

    2014-12-01

    Huntington disease is an autosomal-dominant neurodegenerative disease of mid-life onset caused by expansion of a polymorphic trinucleotide (CAG) repeat. Variable penetrance for alleles carrying 36-39 repeats has been noted, but the disease appears fully penetrant when the repeat numbers are >40. An abnormal CAG repeat may expand, contract, or be stably transmitted when passed from parent to child. Assays used to diagnose Huntington disease must be optimized to ensure the accurate and unambiguous quantitation of CAG repeat length. This document provides an overview of Huntington disease and methodological considerations for Huntington disease testing. Examples of laboratory reports are also included.

  20. Do English NHS Microbiology laboratories offer adequate services for the diagnosis of UTI in children? Healthcare Quality Improvement Partnership (HQIP) Audit of Standard Operational Procedures.

    PubMed

    McNulty, Cliodna A M; Verlander, Neville Q; Moore, Philippa C L; Larcombe, James; Dudley, Jan; Banerjee, Jaydip; Jadresic, Lyda

    2015-09-01

    The National Institute of Care Excellence (NICE) 2007 guidance CG54, on urinary tract infection (UTI) in children, states that clinicians should use urgent microscopy and culture as the preferred method for diagnosing UTI in the hospital setting for severe illness in children under 3 years old and from the GP setting in children under 3 years old with intermediate risk of severe illness. NICE also recommends that all 'infants and children with atypical UTI (including non-Escherichia coli infections) should have renal imaging after a first infection'. We surveyed all microbiology laboratories in England with Clinical Pathology Accreditation to determine standard operating procedures (SOPs) for urgent microscopy, culture and reporting of children's urine and to ascertain whether the SOPs facilitate compliance with NICE guidance. We undertook a computer search in six microbiology laboratories in south-west England to determine urine submissions and urine reports in children under 3 years. Seventy-three per cent of laboratories (110/150) participated. Enterobacteriaceae that were not E. coli were reported only as coliforms (rather than non-E. coli coliforms) by 61% (67/110) of laboratories. Eighty-eight per cent of laboratories (97/110) provided urgent microscopy for hospital and 54% for general practice (GP) paediatric urines; 61% of laboratories (confidence interval 52-70%) cultured 1 μl volume of urine, which equates to one colony if the bacterial load is 106 c.f.u. l(-1). Only 22% (24/110) of laboratories reported non-E. coli coliforms and provided urgent microscopy for both hospital and GP childhood urines; only three laboratories also cultured a 5 μl volume of urine. Only one of six laboratories in our submission audit had a significant increase in urine submissions and urines reported from children less than 3 years old between the predicted pre-2007 level in the absence of guidance and the 2008 level following publication of the NICE guidance. Less than a

  1. Implementing the Science Assessment Standards: Developing and validating a set of laboratory assessment tasks in high school biology

    NASA Astrophysics Data System (ADS)

    Saha, Gouranga Chandra

    Very often a number of factors, especially time, space and money, deter many science educators from using inquiry-based, hands-on, laboratory practical tasks as alternative assessment instruments in science. A shortage of valid inquiry-based laboratory tasks for high school biology has been cited. Driven by this need, this study addressed the following three research questions: (1) How can laboratory-based performance tasks be designed and developed that are doable by students for whom they are designed/written? (2) Do student responses to the laboratory-based performance tasks validly represent at least some of the intended process skills that new biology learning goals want students to acquire? (3) Are the laboratory-based performance tasks psychometrically consistent as individual tasks and as a set? To answer these questions, three tasks were used from the six biology tasks initially designed and developed by an iterative process of trial testing. Analyses of data from 224 students showed that performance-based laboratory tasks that are doable by all students require careful and iterative process of development. Although the students demonstrated more skill in performing than planning and reasoning, their performances at the item level were very poor for some items. Possible reasons for the poor performances have been discussed and suggestions on how to remediate the deficiencies have been made. Empirical evidences for validity and reliability of the instrument have been presented both from the classical and the modern validity criteria point of view. Limitations of the study have been identified. Finally implications of the study and directions for further research have been discussed.

  2. Intensive archaeological survey of the proposed Savannah River Ecology Laboratory Conference Center and Educational Facility, Savannah River Site, Aiken County, South Carolina

    SciTech Connect

    Stephenson, K.; Crass, D.C.; Sassaman, K.E.

    1993-02-01

    Documented in this report are the methods and results of an intensive archaeological survey for the proposed University of Georgia Savannah River Ecology Laboratory (SREL) Conference Center and Educational Facility on the DOE Savannah River Site (SRS). Archaeological investigations conducted by the Savannah River Archaeological Research Program (SRARP) on the 70-acre project area and associated rights-of-way consisted of subsurface testing at two previously recorded sites and the discovery of one previously unrecorded site. The results show that 2 sites contain archaeological remains that may yield significant information about human occupations in the Aiken Plateau and are therefore considered eligible for nomination to the National Register of Historic Places. Adverse impacts to these sites can be mitigated through avoidance.

  3. Nanotechnology for photodynamic therapy: a perspective from the Laboratory of Dr. Michael R. Hamblin in the Wellman Center for Photomedicine at Massachusetts General Hospital and Harvard Medical School.

    PubMed

    Hamblin, Michael R; Chiang, Long Y; Lakshmanan, Shanmugamurthy; Huang, Ying-Ying; Garcia-Diaz, Maria; Karimi, Mahdi; de Souza Rastelli, Alessandra Nara; Chandran, Rakkiyappan

    2015-08-01

    The research interests of the Hamblin Laboratory are broadly centered on the use of different kinds of light to treat many different diseases. Photodynamic therapy (PDT) uses the combination of dyes with visible light to produce reactive oxygen species and kill bacteria, cancer cells and destroy unwanted tissue. Likewise, UV light is also good at killing especially pathogens. By contrast, red or near-infrared light can have the opposite effect, to act to preserve tissue from dying and can stimulate healing and regeneration. In all these applications, nanotechnology is having an ever-growing impact. In PDT, self-assembled nano-drug carriers (micelles, liposomes, etc.) play a great role in solubilizing the photosensitizers, metal nanoparticles can carry out plasmon resonance enhancement, and fullerenes can act as photosensitizers, themselves. In the realm of healing, single-walled carbon nanotubes can be electrofocused to produce nano-electonic biomedical devices, and nanomaterials will play a great role in restorative dentistry.

  4. Production and isolation of homologs of flerovium and element 115 at the Lawrence Livermore National Laboratory Center for Accelerator Mass Spectrometry

    SciTech Connect

    Despotopulos, John D.; Kmak, Kelly N.; Gharibyan, Narek; Brown, Thomas A.; Grant, Patrick M.; Henderson, Roger A.; Moody, Kent J.; Tumey, Scott J.; Shaughnessy, Dawn A.; Sudowe, Ralf

    2015-10-01

    Here, new procedures have been developed to isolate no-carrier-added (NCA) radionuclides of the homologs and pseudo-homologs of flerovium (Hg, Sn) and element 115 (Sb), produced by 12–15 MeV proton irradiation of foil stacks with the tandem Van-de-Graaff accelerator at the Lawrence Livermore National Laboratory Center for Accelerator Mass Spectrometry (CAMS) facility. The separation of 113Sn from natIn foil was performed with anion-exchange chromatography from hydrochloric and nitric acid matrices. A cation-exchange chromatography method based on hydrochloric and mixed hydrochloric/hydroiodic acids was used to separate 124Sb from natSn foil. A procedure using Eichrom TEVA resin was developed to separate 197Hg from Au foil. These results demonstrate the suitability of using the CAMS facility to produce NCA radioisotopes for studies of transactinide homologs.

  5. Production and isolation of homologs of flerovium and element 115 at the Lawrence Livermore National Laboratory Center for Accelerator Mass Spectrometry

    DOE PAGES

    Despotopulos, John D.; Kmak, Kelly N.; Gharibyan, Narek; ...

    2015-10-01

    Here, new procedures have been developed to isolate no-carrier-added (NCA) radionuclides of the homologs and pseudo-homologs of flerovium (Hg, Sn) and element 115 (Sb), produced by 12–15 MeV proton irradiation of foil stacks with the tandem Van-de-Graaff accelerator at the Lawrence Livermore National Laboratory Center for Accelerator Mass Spectrometry (CAMS) facility. The separation of 113Sn from natIn foil was performed with anion-exchange chromatography from hydrochloric and nitric acid matrices. A cation-exchange chromatography method based on hydrochloric and mixed hydrochloric/hydroiodic acids was used to separate 124Sb from natSn foil. A procedure using Eichrom TEVA resin was developed to separate 197Hg frommore » Au foil. These results demonstrate the suitability of using the CAMS facility to produce NCA radioisotopes for studies of transactinide homologs.« less

  6. Nanotechnology for photodynamic therapy: a perspective from the Laboratory of Dr. Michael R. Hamblin in the Wellman Center for Photomedicine at Massachusetts General Hospital and Harvard Medical School

    PubMed Central

    Hamblin, Michael R.; Chiang, Long Y.; Lakshmanan, Shanmugamurthy; Huang, Ying-Ying; Garcia-Diaz, Maria; Karimi, Mahdi; de Souza Rastelli, Alessandra Nara; Chandran, Rakkiyappan

    2015-01-01

    The research interests of the Hamblin Laboratory are broadly centered on the use of different kinds of light to treat many different diseases. Photodynamic therapy (PDT) uses the combination of dyes with visible light to produce reactive oxygen species and kill bacteria, cancer cells and destroy unwanted tissue. Likewise, UV light is also good at killing especially pathogens. By contrast, red or near-infrared light can have the opposite effect, to act to preserve tissue from dying and can stimulate healing and regeneration. In all these applications, nanotechnology is having an ever-growing impact. In PDT, self-assembled nano-drug carriers (micelles, liposomes, etc.) play a great role in solubilizing the photosensitizers, metal nanoparticles can carry out plasmon resonance enhancement, and fullerenes can act as photosensitizers, themselves. In the realm of healing, single-walled carbon nanotubes can be electrofocused to produce nano-electonic biomedical devices, and nanomaterials will play a great role in restorative dentistry. PMID:26640747

  7. An Overview of Current Capabilities and Research Activities in the Airspace Operations Laboratory at NASA Ames Research Center

    NASA Technical Reports Server (NTRS)

    Prevot, Thomas; Smith, Nancy M.; Palmer, Everett; Callantine, Todd; Lee, Paul; Mercer, Joey; Homola, Jeff; Martin, Lynne; Brasil, Connie; Cabrall, Christopher

    2014-01-01

    The Airspace Operations Laboratory at NASA Ames conducts research to provide a better understanding of roles, responsibilities, and requirements for human operators and automation in future air traffic management (ATM) systems. The research encompasses developing, evaluating, and integrating operational concepts and technologies for near-, mid-, and far-term air traffic operations. Current research threads include efficient arrival operations, function allocation in separation assurance and efficient airspace and trajectory management. The AOL has developed powerful air traffic simulation capabilities, most notably the Multi Aircraft Control System (MACS) that is used for many air traffic control simulations at NASA and its partners in government, academia and industry. Several additional NASA technologies have been integrated with the AOL's primary simulation capabilities where appropriate. Using this environment, large and small-scale system-level evaluations can be conducted to help make near-term improvements and transition NASA technologies to the FAA, such as the technologies developed under NASA's Air Traffic Management Demonstration-1 (ATD-1). The AOL's rapid prototyping and flexible simulation capabilities have proven a highly effective environment to progress the initiation of trajectory-based operations and support the mid-term implementation of NextGen. Fundamental questions about accuracy requirements have been investigated as well as realworld problems on how to improve operations in some of the most complex airspaces in the US. This includes using advanced trajectory-based operations and prototype tools for coordinating arrivals to converging runways at Newark airport and coordinating departures and arrivals in the San Francisco and the New York metro areas. Looking beyond NextGen, the AOL has started exploring hybrid human/automation control strategies as well as highly autonomous operations in the air traffic control domain. Initial results

  8. 42 CFR 493.1775 - Standard: Inspection of laboratories issued a certificate of waiver or a certificate for provider...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... certificate of waiver or a certificate for provider-performed microscopy procedures. 493.1775 Section 493.1775... laboratories issued a certificate of waiver or a certificate for provider-performed microscopy procedures. (a... microscopy procedures is not subject to biennial inspections. (b) If necessary, CMS or a CMS agent...

  9. Space Food Systems Laboratory

    NASA Technical Reports Server (NTRS)

    Perchonok, Michele; Russo, Dane M. (Technical Monitor)

    2001-01-01

    The Space Food Systems Laboratory (SFSL) is a multipurpose laboratory responsible for space food and package research and development. It is located on-site at Johnson Space Center in Building 17. The facility supports the development of flight food, menus, packaging and food related hardware for Shuttle, International Space Station, and Advanced Life Support food systems. All foods used to support NASA ground tests and/or missions must meet the highest standards before they are 'accepted' for use on actual space flights. The foods are evaluated for nutritional content, sensory acceptability, safety, storage and shelf life, and suitability for use in micro-gravity. The food packaging is also tested to determine its functionality and suitability for use in space. Food Scientist, Registered Dieticians, Packaging Engineers, Food Systems Engineers, and Technicians staff the Space Food Systems Laboratory.

  10. A Statistical Review of DWPF Laboratory Data Including Measurements of the ARG-1 Standard for Batches 94 - 263.

    SciTech Connect

    THOMAS, EDWARDS

    2004-11-30

    Measurements of calibration and bench standards as well as samples of ARG-1 that were performed by the DWPF Lab during the processing of batches 94 through 263 were provided to SCS for review. Three datasets, one associated with each of three preparation methods (Cold Chem, Mixed Acid, and Fusion) were included in the review. The review conducted covered several areas of investigation. Biases in these measurements relative to the reference values for the standards including ARG-1 were estimated and found to be of no practical concern. Percent relative standard deviations for these data also were determined. Sources of variation in the measurements (i.e., batch-to-batch and within process batch) were estimated and compared. An investigation into evidence of instrument drift during a group of measurements representing a prototypical block was conducted for each preparation method using pairs of calibration and bench standards. No evidence of instrument drift at levels of practical concern was seen in these data. Also, the replicates of calibration standards at the beginning of each analytical block were found to be unnecessary. The uncertainties of the measurements, which incorporated biases and precision errors, were computed for the calibration standards, bench standards, and ARG-1. The limits for these uncertainties were compared to the current, LIMS operating limits for the errors in the measurements of these standards. These comparisons may provide opportunities for revising the LIMS limits. Comparisons between MFT and SME results were made for both the Mixed Acid and the Fusion prep methods. There was no evidence of differences (in either bias or precision) between the results for these two tanks for either of the two prep methods.

  11. Response to the great East Japan earthquake of 2011 and the Fukushima nuclear crisis: the case of the Laboratory Animal Research Center at Fukushima Medical University.

    PubMed

    Katahira, Kiyoaki; Sekiguchi, Miho

    2013-01-01

    A magnitude 9.0 great earthquake, the 2011 off the Pacific coast of Tohoku Earthquake, occurred on March 11, 2011, and subsequent Fukushima Daiichi Nuclear Power Station (Fukushima NPS) accidents stirred up natural radiation around the campus of Fukushima Medical University (FMU). FMU is located in Fukushima City, and is 57 km to the northwest of Fukushima NPS. Due to temporary failure of the steam boilers, the air conditioning system for the animal rooms, all autoclaves, and a cage washer could not be used at the Laboratory Animal Research Center (LARC) of FMU. The outside air temperature dropped to zero overnight, and the temperature inside the animal rooms fell to 10°C for several hours. We placed sterilized nesting materials inside all cages to encourage rodents to create nests. The main water supply was cut off for 8 days in all, while supply of steam and hot water remained unavailable for 12 days. It took 20 days to restore the air conditioning system to normal operation at the facility. We measured radiation levels in the animal rooms to confirm the safety of care staff and researchers. On April 21, May 9, and June 17, the average radiation levels at a central work table in the animal rooms with HEPA filters were 46.5, 44.4, and 43.4 cpm, respectively, which is equal to the background level of the equipment. We sincerely hope our experiences will be a useful reference regarding crisis management for many institutes having laboratory animals.

  12. AFSC Standardization Conference, 1553, 1589, 1750, 1760, Ada, November 18-20, 1980, Dayton Convention Center, Dayton, Ohio, Volume II. Proceedings Standards,

    DTIC Science & Technology

    1980-11-01

    bfolk non,nr Computer Instruction Set Architecture, Multiplexing, Compilers, Support Soft- ware, Data Bus, MIL- STD -I589, MTL- STD -1750, MIL- STD -1553, ML... STD -1760, Digital Avionica , Systems Integration, Stores Interface, Standardization. 70 ABST PACT ’Conthton "n iS.~O ,d. it ne ......- y nd Ide-cify by...PATTERSON AIR FORCE BASE, OHIO 45433 FOREWORD Air Force Systems Command sponsored two MIL- STD -1553 Multiplex Data Bus Conferences, one in 1976 and one in

  13. Safety Basis Requirements for Nonnuclear Facilities at Lawrence Livermore National Laboratory Site-Specific Work Smart Standard Revision 3 December 2006

    SciTech Connect

    Beach, D; Brereton, S; Failor, R; Hildum, J; Ingram, C; Spagnolo, S; van Warmerdam, C

    2007-06-07

    This standard establishes requirements that, when coupled with Lawrence Livermore National Laboratory's (LLNL's) Integrated Safety Management System (ISMS) methods and other Work Smart Standards for assuring worker safety, assure that the impacts of nonnuclear operations authorized in LLNL facilities are well understood and controlled in a manner that protects the health of workers, the public, and the environment. All LLNL facilities shall be classified based on potential for adverse impact of operations to the health of co-located (i.e., nearby) workers and the public in accordance with this standard, Title 10 Code of Federal Regulations (10 CFR) 830, Subpart B, and Department of Energy Order (DOE O) 420.2A.

  14. 42 CFR 493.1101 - Standard: Facilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Standard: Facilities. 493.1101 Section 493.1101 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... § 493.1101 Standard: Facilities. (a) The laboratory must be constructed, arranged, and maintained...

  15. 42 CFR 493.1262 - Standard: Mycobacteriology.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 5 2014-10-01 2014-10-01 false Standard: Mycobacteriology. 493.1262 Section 493.1262 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Quality System for Nonwaived Testing...

  16. 42 CFR 493.1262 - Standard: Mycobacteriology.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Standard: Mycobacteriology. 493.1262 Section 493.1262 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Quality System for Nonwaived Testing...

  17. 42 CFR 493.1262 - Standard: Mycobacteriology.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false Standard: Mycobacteriology. 493.1262 Section 493.1262 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Quality System for Nonwaived Testing...

  18. 42 CFR 493.1263 - Standard: Mycology.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Standard: Mycology. 493.1263 Section 493.1263 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Quality System for Nonwaived Testing...

  19. 42 CFR 493.1262 - Standard: Mycobacteriology.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Standard: Mycobacteriology. 493.1262 Section 493.1262 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Quality System for Nonwaived Testing...

  20. 42 CFR 493.1263 - Standard: Mycology.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Standard: Mycology. 493.1263 Section 493.1263 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Quality System for Nonwaived Testing...

  1. 42 CFR 493.1263 - Standard: Mycology.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Standard: Mycology. 493.1263 Section 493.1263 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Quality System for Nonwaived Testing...

  2. 42 CFR 493.1262 - Standard: Mycobacteriology.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Standard: Mycobacteriology. 493.1262 Section 493.1262 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Quality System for Nonwaived Testing...

  3. 42 CFR 493.1263 - Standard: Mycology.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 5 2014-10-01 2014-10-01 false Standard: Mycology. 493.1263 Section 493.1263 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Quality System for Nonwaived Testing...

  4. 42 CFR 493.1269 - Standard: Hematology.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 5 2014-10-01 2014-10-01 false Standard: Hematology. 493.1269 Section 493.1269 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Quality System for Nonwaived Testing...

  5. Proficiency Testing as a tool to monitor consistency of measurements in the IAEA/WHO Network of Secondary Standards Dosimetry Laboratories

    NASA Astrophysics Data System (ADS)

    Meghzifene, Ahmed; Czap, Ladislav; Shortt, Ken

    2008-08-01

    The International Atomic Energy Agency (IAEA) and the World Health Organization (WHO) established a Network of Secondary Standards Dosimetry Laboratories (IAEA/WHO SSDL Network) in 1976. Through SSDLs designated by Member States, the Network provides a direct link of national dosimetry standards to the international measurement system of standards traceable to the Bureau International des Poids et Mesures (BIPM). Within this structure and through the proper calibration of field instruments, the SSDLs disseminate S.I. quantities and units. To ensure that the services provided by SSDL members to end-users follow internationally accepted standards, the IAEA has set up two different comparison programmes. One programme relies on the IAEA/WHO postal TLD service and the other uses comparisons of calibrated ionization chambers to help the SSDLs verify the integrity of their national standards and the procedures used for the transfer of the standards to the end-users. The IAEA comparisons include 60Co air kerma (NK) and absorbed dose to water (ND,W) coefficients. The results of the comparisons are confidential and are communicated only to the participants. This is to encourage participation of the laboratories and their full cooperation in the reconciliation of any discrepancy. This work describes the results of the IAEA programme comparing calibration coefficients for radiotherapy dosimetry, using ionization chambers. In this programme, ionization chambers that belong to the SSDLs are calibrated sequentially at the SSDL, at the IAEA, and again at the SSDL. As part of its own quality assurance programme, the IAEA has participated in several regional comparisons organized by Regional Metrology Organizations. The results of the IAEA comparison programme show that the majority of SSDLs are capable of providing calibrations that fall inside the acceptance level of 1.5% compared to the IAEA.

  6. Produce Live News Broadcasts Using Standard AV Equipment: A Success Story from the Le Center High School in Minnesota.

    ERIC Educational Resources Information Center

    Rostad, John

    1997-01-01

    Describes the production of news broadcasts on video by a high school class in Le Center, Minnesota. Topics include software for Apple computers, equipment used, student responsibilities, class curriculum, group work, communication among the production crew, administrative and staff support, and future improvements. (LRW)

  7. A Love Supreme--Riffing on the Standards: Placing Ideas at the Center of High Stakes Schooling

    ERIC Educational Resources Information Center

    Kohl, Herbert

    2006-01-01

    The Fake Book is a square spiral bound Xeroxed book, about 7" by 7", maybe 250 pages long. It's all music--the notes, usually in C or B minor, of hundreds of standard tunes, jazz, pop, and every once in a while, classical. The Fake Book and all of its variants provide an evolving canon of tunes that defines a set of common standards for…

  8. Final report on key comparison CCAUV.A-K5: pressure calibration of laboratory standard microphones in the frequency range 2 Hz to 10 kHz

    NASA Astrophysics Data System (ADS)

    Avison, Janine; Barham, Richard

    2014-01-01

    This document and the accompanying spreadsheets constitute the final report for key comparison CCAUV.A-K5 on the pressure calibration of laboratory standard microphones in the frequency range from 2 Hz to 10 kHz. Twelve national measurement institutes took part in the key comparison and the National Physical Laboratory piloted the project. Two laboratory standard microphones IEC type LS1P were circulated to the participants and results in the form of regular calibration certificates were collected throughout the project. One of the microphones was subsequently deemed to have compromised stability for the purpose of deriving a reference value. Consequently the key comparison reference value (KCRV) has been made based on the weighted mean results for sensitivity level and for sensitivity phase from just one of the microphones. Corresponding degrees of equivalence (DoEs) have also been calculated and are presented. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCAUV, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  9. Laboratory Frame Analysis of e+e-→μ+μ- Scattering in the Noncommutative Standard Model at Linear Collider

    NASA Astrophysics Data System (ADS)

    Das, Prasanta Kumar; Prakash, Abhishodh

    2012-09-01

    We study the muon pair production e+e-→μ+μ- in the framework of the nonminimal noncommutative standard model (NCSM) to the second-order of the noncommutative (NC) parameter Θμν at linear collider. The {O}(Θ 2) momentum-dependent NC interaction significantly modifies the cross-section and angular distributions which are different from the standard model. After including the effects of earth's rotation we analyze the time-averaged and time-dependent observables in detail. The time-averaged azimuthal distribution of the cross-section shows significant departure from the standard model which can be tested at the upcoming linear collider. We find strong dependence of total cross-section (time-averaged) and their distributions on the orientation and the magnitude of the NC electric vector (ΘE). Assuming that the future linear collider data will differ from the standard model result by 5%, we obtain Λ≥615 GeV and Λ≥946 GeV corresponding to the machine energy Ecom = 1000 GeV and 1500 GeV.

  10. Standardization of protocols to test wheat (Triticum aestivum L.) for reaction to blast in a biocontainment laboratory

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Growth medium, spore age, and inoculum density are essential factors for determining host responses to a plant pathogen. The standardization of these factors is important to obtain adequate and reproducible disease assessments. We are testing US wheat cultivars for reaction to the exotic disease bla...

  11. Altering Public University Admission Standards to Preserve White Group Position in the United States: Results from a Laboratory Experiment

    ERIC Educational Resources Information Center

    Samson, Frank L.

    2013-01-01

    This study identifies a theoretical mechanism that could potentially affect public university admissions standards in a context of demographic change. I explore how demographic changes at a prestigious public university in the United States affect individuals' evaluations of college applications. Responding to a line graph that randomly displays a…

  12. Low energy tests of the standard model: the 12 GeV parity violation program at Jefferson Laboratory

    SciTech Connect

    Krishna S. Kumar

    2010-06-01

    We discuss the current status and prospects of an experimental program of parity-violating asymmetry measurements in the scattering of longitudinally polarized electrons off unpolarized fixed targets. In particular, we focus on those measurements where judicious choices of target species and kinematics allows the theoretical predictions to be made purely in terms of fundamental electroweak couplings with little theoretical uncertainty. If such asymmetries are measured with sufficient precision, they are sensitive to new physics at the TeV scale. After reviewing recent results, two new experimental initiatives called MOLLER and SoLID being designed for the Jefferson Laboratory 12 GeV upgrade are discussed.

  13. Calibration of the NPL secondary standard radionuclide calibrator for 125I seeds used for prostate brachytherapy. National Physical Laboratory.

    PubMed

    Baker, M; Bass, G A; Woods, M J

    2002-01-01

    In the therapeutic use of radionuclides, by far the most rapid growth in recent years is that of 125I seeds used for the treatment of prostate cancer. Large numbers of these seeds are used in each treatment and there is a need for a simple but accurate means of confirming their dose rates. This mechanism requires a transfer device for which the calibration factors are traceable to national standards. The NPL secondary standard radionuclide calibrator, because of its guaranteed reproducibility and traceable calibration procedure, is ideally suited for this purpose. A series of characterisation measurements have been performed on the NPL radionuclide calibrator in order to estimate the uncertainty levels that can be achieved and these are presented together with the relevant calibration factors for some typical seeds.

  14. Lesson Plans for the Busy Librarian: A Standards Based Approach for the Elementary Library Media Center, Volume 2

    ERIC Educational Resources Information Center

    Keeling, Joyce

    2005-01-01

    The author designed this book, like Volume I of the set, to give elementary school librarians a quick, enjoyable way to coordinate with teachers to teach information literacy and literacy skills aligned with national standards. The chapters in the book include: (1) Kindergarten Lesson Plans; (2) First-Grade Lesson Plans; (3) Second-Grade Lesson…

  15. Objectives and Current Status of the IAEA Network of Centers of Excellence: Training in and Demonstration of Waste Disposal Technologies in Underground Research Laboratories

    SciTech Connect

    Bell, M. J.; Knapp, M. R.

    2003-02-27

    Underground Research Laboratories (URLs) to develop and demonstrate technologies for the safe geologic disposal of radioactive wastes have been established for national purposes by several Member States of the International Atomic Energy Agency (IAEA). Under the auspices of the IAEA, nationally developed URLs and associated research institutions are being offered for use by other nations. These facilities form a Network of Centers of Excellence for training in and development of waste disposal technologies. Experience gained in the operation of the facilities, and through associated experimentation and demonstrations, will be transferred to participating Member States through hands-on work at the facilities. The Network consists of Network Members and Network Participants who share co-operative activities. Network Members are owners of facilities who have offered them to be part of the Network. At this time there are eight Members consisting of six underground facilities, a laboratory, and a university. Network Participants can potentially come from any interested IAEA Member State having spent nuclear fuel for disposal, with or without an established program for geologic disposal. There are presently about 15 Network Participants. A significant Network activity beginning in 2003 will be a Coordinated Research Project (CRP) on characterization and evaluation of swelling clays for use in engineered barrier systems of geologic repositories. At the end of this project, every involved Member State should be able to identify and characterize a swelling clay that is suitable for use in a geologic repository. As the Network grows, additional CRPs to be carried out in the Underground Research Facilities of the Network Members will be defined.

  16. Thermal Performance of Biological Substance Systems in Vitro Under Static and Dynamic Conditions at the Cryogenic Test Laboratory, NASA Kennedy Space Center, USA

    NASA Technical Reports Server (NTRS)

    Augustynowicz, S. D.; Fesmire, James E.; Steinrock, T. (Technical Monitor)

    2001-01-01

    A unique research program, including a comprehensive study of thermal performance at cryogenic vacuum insulation systems, was performed at the NASA Kennedy Space Center. The main goal was to develop a new soft vacuum system (from 1 torr to 10 torr) that provides an intermediate level of performance (k-value below 4.8 mW/m-K). Liquid nitrogen boil-off methods were used to test conventional materials, novel materials, and certain combinations. The test articles included combinations of aluminum foil, fiberglass paper, polyester fabric, silica aerogel composite blanket, fumed silica, silica aerogel powder, and syntactic foam. A new LCI system was developed at the Cryogenics Test Laboratory. This system performs exceptionally well at soft vacuum levels and nearly as good as an MLI at high vacuum levels. Apparent thermal conductivities for the LCI range from 2 mW/m-K at soft vacuum to 0.1 mW/m-K at high vacuum. Several cryostats were designed, constructed, and calibrated by the Cryogenics Test Laboratory at KSC NASA as part of this research program. The cryostat test apparatus is a liquid nitrogen boil-off calorimeter system for direct measurement of the apparent thermal conductivity at a fixed vacuum level between 5 x 10(exp -5) and 760 torr. The apparatus is also used for transient measurements of temperature profiles. The development of efficient, robust cryogenic insulation systems has been a targeted area of research for a number of years. Improved methods of characterization, testing, and evaluation of complex biological substance systems for cryosurgery and cryobiology are the focus of this paper.

  17. Thrombotic thrombocytopenic purpura - analysis of clinical features, laboratory characteristics and therapeutic outcome of 24 patients treated at a Tertiary Care Center in Saudi Arabia

    PubMed Central

    Iqbal, Shahid; Zaidi, Syed Z. A.; Motabi, Ibraheem H; Alshehry, Nawal Faiez; AlGhamdi, Mubarak S.; Tailor, Imran Khan

    2016-01-01

    Objective: Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease. The primary aim was overall response rate (ORR) assessment in the treated patients Methods: This retrospective study included 24 patients treated during 2006-2015. TTP patients with microangiopathic hemolysis (MAHA) and thrombocytopenia were included. We analyzed clinical features, laboratory characteristics and treatment outcomes of 24 TTP patients treated at our tertiary care center (KFMC). Results: Twenty-four TTP patients (18 females; 6 males) had a mean age of 33.5±13.9 years; 22(91%) had neurologic features, 7(29%) fever, 10(42%) renal impairment; 4(20.83%) cardiac manifestations; 22(91.7%) had triad with additional neurologic abnormalities; only 2(8.2%) had pentad of TTP. Majority (54.16%) had idiopathic TTP. All patients received therapeutic plasma exchange (TPE); 23(95.8%) received adjunctive corticosteroids and 13(54.2%) received rituximab either due to refractoriness to TPE on ~day7, or earlier. Twenty-one out of 24 (87.5%) achieved complete remission (CR) without any subsequent relapse. At 22 months (median, range 1-113), 20 patients (83.3%) are alive at the time of report. Three patients died during acute episode because of sever disease or delayed treatment and one died in CR. Conclusion: TPE, steroids and or rituximab was very effective in preventing high risk of mortality and achieving durable CR in 87.5% of patients. More awareness is needed for early diagnosis and early referral to centers with appropriate tertiary care facilities.. PMID:28083052

  18. Worker Safety and Health Issues Associated with the DOE Environmental Cleanup Program: Insights From the DOE Laboratory Directors' Environmental and Occupational/Public health Standards Steering Group

    SciTech Connect

    M.C. Edelson; Samuel C. Morris; Joan M. Daisey

    2001-03-01

    The U.S. Department of Energy (DOE) Laboratory Directors' Environmental and Occupational/Public Health Standards Steering Group (or ''SSG'') was formed in 1990. It was felt then that ''risk'' could be an organizing principle for environmental cleanup and that risk-based cleanup standards could rationalize clean up work. The environmental remediation process puts workers engaged in cleanup activities at risk from hazardous materials and from the more usual hazards associated with construction activities. In a real sense, the site remediation process involves the transfer of a hypothetical risk to the environment and the public from isolated contamination into real risks to the workers engaged in the remediation activities. Late in its existence the SSG, primarily motivated by its LANL representative, Dr. Harry Ettinger, actively investigated issues associated with worker health and safety during environmental remediation activities. This paper summarizes the insights noted by the SSG. Most continue to be pertinent today.

  19. Analysis of vitamin D status at two academic medical centers and a national reference laboratory: result patterns vary by age, gender, season, and patient location

    PubMed Central

    2013-01-01

    Background Testing for 25-hydroxyvitamin D [25(OH)D] has increased dramatically in recent years. The present report compares overall utilization and results for 25(OH)D orders at two academic medical centers - one in New York and one in Iowa – in order to characterize the vitamin D status of our inpatient and outpatient populations. Results are also compared to those from a national reference laboratory to determine whether patterns at these two institutions reflect those observed nationally. Methods Retrospective data queries of 25(OH)D orders and results were conducted using the laboratory information systems at Weill Cornell Medical College / New York Presbyterian Hospital (WCMC), University of Iowa Hospitals and Clinics (UIHC), and ARUP Laboratories (ARUP). Chart review was conducted for cases with very high or low serum 25(OH)D levels in the WCMC and UIHC datasets. Results The majority of tests were ordered on females and outpatients. Average serum 25(OH)D levels were higher in female versus male patients across most ages in the WCMC, UIHC, and ARUP datasets. As expected, average serum 25(OH)D levels were higher in outpatients than inpatients. Serum 25(OH)D levels showed seasonal periodicity, with average levels higher in summer than winter and correlating to regional UV index. Area plots demonstrated a peak of increased 25(OH)D insufficiency / deficiency in adolescent females, although overall worse 25(OH)D status was found in male versus female patients in the WCMC, UIHC, and ARUP datasets. Surprisingly, improved 25(OH)D status was observed in patients starting near age 50. Finally, chart review of WCMC and UIHC datasets revealed over-supplementation (especially of ≥ 50,000 IU weekly doses) in the rare cases of very high 25(OH)D levels. General nutritional deficiency and/or severe illness was found in most cases of severe 25(OH)D deficiency. Conclusions 25(OH)D status of patients seen by healthcare providers varies according to age, gender, season

  20. Air Force Space Command. Space and Missile Systems Center Standard. Electromagnetic Compatibility Requirements for Space Equipment and Systems

    DTIC Science & Technology

    2008-06-13

    methods applicable to most modern receivers.) (L) 6.23 Conducted Susceptibility, Antenna Port, Cross Modulation, 30Hz-40GHz (CS105) a. Purpose... methods of MIL-STD-461F, with changes in antennas , preamplifiers and receiver(s) appropriate for the frequency range(s). d4. Verification: Platform...requirements, using flight-like antennas , transmitters representative of the RFI sources of concern, and by standard measurement methods of electrical

  1. Space and Missile Systems Center Standard: Technical Requirements for Electronic Parts, Materials, and Processes used in Space Vehicles

    DTIC Science & Technology

    2013-04-12

    PMP shall include: a. MIL-DTL-16878 wire types b. All Polyvinyl chloride (PVC) insulated wire and cable. c. SAE-AS22759 wire with only one PTFE...following specifications, standards, and handbooks of the issue listed in the current version of the Department of Defense Index of Specifications and... Handbook (Volumes 1 through 5) MIL-HDBK-23A(3) Structural Sandwich Composites (CANCELED) MIL-STD-130 Identification Marking of U.S. Military

  2. Standards for Quality Agricultural Occupations Programs as Validated by the Agricultural Occupations Teachers in the Secondary and Area Vocational Centers of Illinois. Part I and Part II. [A Final Report].

    ERIC Educational Resources Information Center

    Stitt, Thomas R.; And Others

    This report details the process of the Illinois Standards Project to develop, adopt, and implement standards of quality for agricultural occupation programs at both the secondary and postsecondary levels throughout Illinois. Part I, standards for quality programs in area vocational centers excluding metropolitan areas, is divided into three…

  3. Measurement of Sedimentary Interbed Hydraulic Properties and Their Hydrologic Influence near the Idaho Nuclear Technology and Engineering Center at the Idaho National Engineering and Environmental Laboratory

    USGS Publications Warehouse

    Perkins, Kim S.

    2003-01-01

    Disposal of wastewater to unlined infiltration ponds near the Idaho Nuclear Technology and Engineering Center (INTEC), formerly known as the Idaho Chemical Processing Plant, at the Idaho National Engineering and Environmental Laboratory (INEEL) has resulted in the formation of perched water bodies in the unsaturated zone (Cecil and others, 1991). The unsaturated zone at INEEL comprises numerous basalt flows interbedded with thinner layers of coarse- to fine-grained sediments and perched ground-water zones exist at various depths associated with massive basalts, basalt-flow contacts, sedimentary interbeds, and sediment-basalt contacts. Perched ground water is believed to result from large infiltration events such as seasonal flow in the Big Lost River and wastewater discharge to infiltration ponds. Evidence from a large-scale tracer experiment conducted in 1999 near the Radioactive Waste Management Complex (RWMC), approximately 13 km from the INTEC, indicates that rapid lateral flow of perched water in the unsaturated zone may be an important factor in contaminant transport at the INEEL (Nimmo and others, 2002b). Because sedimentary interbeds, and possibly baked-zone alterations at sediment-basalt contacts (Cecil and other, 1991) play an important role in the generation of perched water it is important to assess the hydraulic properties of these units.

  4. Selection of a Data Acquisition and Controls System Communications and Software Architecture for Johnson Space Center's Space Environment Simulation Laboratory Thermal and Vacuum Test Facilities

    NASA Technical Reports Server (NTRS)

    Jordan, Eric A.

    2004-01-01

    Upgrade of data acquisition and controls systems software at Johnson Space Center's Space Environment Simulation Laboratory (SESL) involved the definition, evaluation and selection of a system communication architecture and software components. A brief discussion of the background of the SESL and its data acquisition and controls systems provides a context for discussion of the requirements for each selection. Further framework is provided as upgrades to these systems accomplished in the 1990s and in 2003 are compared to demonstrate the role that technological advances have had in their improvement. Both of the selections were similar in their three phases; 1) definition of requirements, 2) identification of candidate products and their evaluation and testing and 3) selection by comparison of requirement fulfillment. The candidates for the communication architecture selection embraced several different methodologies which are explained and contrasted. Requirements for this selection are presented and the selection process is described. Several candidates for the software component of the data acquisition and controls system are identified, requirements for evaluation and selection are presented, and the evaluation process is described.

  5. Challenges in the Management and Stewardship of Airborne Observational Data at the National Center for Atmospheric Research (NCAR) Earth Observing Laboratory (EOL)

    NASA Astrophysics Data System (ADS)

    Aquino, J.; Daniels, M. D.

    2015-12-01

    The National Science Foundation (NSF) provides the National Center for Atmospheric Research (NCAR) Earth Observing Laboratory (EOL) funding for the operation, maintenance and upgrade of two research aircraft: the NSF/NCAR High-performance Instrumented Airborne Platform for Environmental Research (HIAPER) Gulfstream V and the NSF/NCAR Hercules C-130. A suite of in-situ and remote sensing airborne instruments housed at the EOL Research Aviation Facility (RAF) provide a basic set of measurements that are typically deployed on most airborne field campaigns. In addition, instruments to address more specific research requirements are provided by collaborating participants from universities, industry, NASA, NOAA or other agencies (referred to as Principal Investigator, or PI, instruments). At the 2014 AGU Fall Meeting, a poster (IN13B-3639) was presented outlining the components of Airborne Data Management included field phase data collection, formats, data archival and documentation, version control, storage practices, stewardship and obsolete data formats, and public data access. This talk will cover lessons learned, challenges associated with the above components, and current developments to address these challenges, including: tracking data workflows for aircraft instrumentation to facilitate identification, and correction, of gaps in these workflows; implementation of dataset versioning guidelines; and assignment of Digital Object Identifiers (DOIs) to data and instrumentation to facilitate tracking data and facility use in publications.

  6. Technology Evaluations Related to Mercury, Technetium, and Chloride in Treatment of Wastes at the Idaho Nuclear Technology and Engineering Center of the Idaho National Engineering and Environmental Laboratory

    SciTech Connect

    C. M. Barnes; D. D. Taylor; S. C. Ashworth; J. B. Bosley; D. R. Haefner

    1999-10-01

    The Idaho High-Level Waste and Facility Disposition Environmental Impact Statement defines alternative for treating and disposing of wastes stored at the Idaho Nuclear Technology and Engineering Center. Development is required for several technologies under consideration for treatment of these wastes. This report contains evaluations of whether specific treatment is needed and if so, by what methods, to remove mercury, technetium, and chlorides in proposed Environmental Impact Statement treatment processes. The evaluations of mercury include a review of regulatory requirements that would apply to mercury wastes in separations processes, an evaluation of the sensitivity of mercury flowrates and concentrations to changes in separations processing schemes and conditions, test results from laboratory-scale experiments of precipitation of mercury by sulfide precipitation agents from the TRUEX carbonate wash effluent, and evaluations of methods to remove mercury from New Waste Calcining Facility liquid and gaseous streams. The evaluation of technetium relates to the need for technetium removal and alternative methods to remove technetium from streams in separations processes. The need for removal of chlorides from New Waste Calcining Facility scrub solution is also evaluated.

  7. In vitro susceptibility of filamentous fungi to itraconazole, voriconazole and posaconazole by Clinical and Laboratory Standards Institute reference method and E-test.

    PubMed

    Kondori, N; Svensson, E; Mattsby-Baltzer, I

    2011-09-01

    The use of anti-fungal agents has increased dramatically in recent years and new drugs have been developed. Several methods are available for determinations of their specific biological activities, i.e. the standard method for minimum inhibitory concentration-determination is described in M-38 [Clinical and Laboratory Standards Institute document M-38 (CLSI M-38)]. However, alternative methods, such as the E-test, are currently available in Mycology laboratories. The susceptibilities of clinical isolates of Aspergillus spp. (n = 29), Fusarium spp. (n = 5), zygomycetes (n = 21) and Schizophyllum (n = 1) were determined for itraconazole, voriconazole and posaconazole, using the CLSI M-38-A broth dilution method and also by the E-test. A good overall agreement (83.7%) between the two methods for all drugs and organisms was observed. Analyses of voriconazole showed a better agreement (93%) between the methods than posaconazole and itraconazole (85% and 74% respectively). Aspergillus spp. were the most susceptible fungi to the anti-fungal agents tested in this study. Posaconazole was the most active drug against filamentous fungi in vitro, followed by itraconazole and voriconazole. The latter (voriconazole) demonstrated no significant in vitro activity against zygomycetes.

  8. Effect of Fe (III) on Pseudokirchneriella subcapitata at circumneutral pH in standard laboratory tests is explained by nutrient sequestration.

    PubMed

    Arbildua, Jose J; Villavicencio, German; Urrestarazu, Paola; Opazo, Margaret; Brix, Kevin V; Adams, William J; Rodriguez, Patricio H

    2017-04-01

    The complex chemistry of iron (Fe) at circumneutral pH in oxygenated waters and the poor correlation between ecotoxicity results in laboratory and natural waters have led to regulatory approaches for iron based on field studies (US Environmental Protection Agency Water Quality Criteria and European Union Water Framework Directive proposal for Fe). The results of the present study account for the observed differences between laboratory and field observations for Fe toxicity to algae (Pseudokirchneriella subcapitata). Results from standard 72-h assays with Fe at pH 6.3 and pH 8 resulted in similar toxicity values measured as algal biomass, with 50% effect concentrations (EC50) of 3.28 mg/L and 4.95 mg/L total Fe(III), respectively. At the end of the 72-h exposure, however, dissolved Fe concentrations were lower than 30 μg/L for all test concentrations, making a direct toxic effect of dissolved iron on algae unlikely. Analysis of nutrient concentrations in the artificial test media detected phosphorus depletion in a dose-dependent manner that correlated well with algal toxicity. Subsequent experiments adding excess phosphorus after Fe precipitation eliminated the toxicity. These results strongly suggest that observed Fe(III) toxicity on algae in laboratory conditions is a secondary effect of phosphorous depletion. Environ Toxicol Chem 2017;36:952-958. © 2016 SETAC.

  9. A third component causing random variability beside environment and genotype. A reason for the limited success of a 30 year long effort to standardize laboratory animals?

    PubMed

    Gärtner, Klaus

    2012-04-01

    This paper is a review of experiments, performed in our laboratory during the past 20 years, designed to analyse the significance of different components of random variability in quantitative traits in laboratory rats and mice. Reduction of genetic variability by using inbred strains and reduction of environmental variability by highly standardized husbandry in laboratory animals did not remarkably reduce the range of random variability in quantitative biological traits. Neither did a tremendous increase of the environmental variability (i.e., living in a natural setting) increase it. Therefore, the postnatal environment cannot be that important as the source of random variability. Utilizing methods established in twin research, only 20-30% of the range of the body weight in inbred mice were directly estimated to be of environmental origin. The remaining 70-80% were due to a third component creating biological random variability, in addition to the genetic and environmental influences. This third component is effective at or before fertilization and may originate from ooplasmic differences. It is the most important component of the phenotypic random variability, fixing its range and dominating the genetic and the environmental component. The Gaussian distribution of the body weights observed, even in inbred animals, seems to be an arrangement supporting natural selection rather than the consequence of heterogeneous environmental influences. In a group of inbred rats, the males with the highest chance of parenting the next generation were gathered in the central classes of the distribution of the body weight.

  10. Standardized laboratory tests with 21 species of temperate and tropical sepsid flies confirm their suitability as bioassays of pharmaceutical residues (ivermectin) in cattle dung.

    PubMed

    Blanckenhorn, Wolf U; Puniamoorthy, Nalini; Schäfer, Martin A; Scheffczyk, Adam; Römbke, Jörg

    2013-03-01

    Veterinary pharmaceuticals excreted in the dung of treated livestock can have strong non-target effects on the dung organism community. We report results of ecotoxicological tests with ivermectin for 21 species of temperate (Europe, North America) and tropical (Asia, Central America) black scavenger flies (Diptera: Sepsidae), using standardized methods developed previously for the yellow dung fly and the face fly. Our study documents great variation in ivermectin sensitivity of more than two orders of magnitude among species and even populations within species: estimated lethal effect concentrations LC(50) (at which 50% of the flies died) ranged from 0.05 to 18.55 μg/kg dung fresh weight (equivalent to 0.33-132.22 μg/kg dung dry weight). We also show that controlled laboratory tests can--within reasonable limits-be extended to the field or to laboratory settings without climate control, as obtained LC(50) were roughly similar. In addition to lethal effects, our study revealed relevant sub-lethal effects at lower ivermectin concentrations in terms of prolonged development, smaller body size and reduced juvenile growth rate. Finally, oviposition choice experiments showed that females generally do not discriminate against dung containing ivermectin residues. We conclude that sepsid flies are well suited test organisms for pharmaceutical residues in the dung of livestock due to their ease and speed of rearing and handling, particularly in the tropics, where high-tech laboratory equipment is often not available.

  11. Development of radioactive beams at LAMPF for a high precision test of the standard model and as a step towards an IsoSpin Laboratory

    SciTech Connect

    Vieira, D.; Chamberlin, E.; Preston, D.

    1996-07-01

    This is the final report of a three-year, Laboratory-Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). Producing high yields of isotopically pure beams of radioactive heavy ions is the technical challenge facing the IsoSpin Laboratory (ISL). The main objective of this project is to design, fabricate, install, and make operational a thin-target, He- jet system at LAMPF to provide high-intensity {sup 125-139}Cs isotopes for an atomic parity nonconservation (PNC) experiment and as a robust production source for radioactive beams. The Cs-PNC experiment itself would take several years beyond the successful completion of the developments outlined in this project. The experiment outlined in this project. The experiment seeks to measure the 6S-7S PNC transition rate for this series of Cs isotopes. From the ratios of these rates measured in the different isotopes, a fundamental test of the standard model can be made at the level of 0. 2{percent}. Herein, we describe the successful operation of a thin- target, He-jet system operating at primary beam intensities of up to 700 {mu}A with production yields of 10{sup 7} to 10{sup 8} atoms/s for a wide range of nonvolatile and Cs radioisotopes. 7 refs., 3 figs.

  12. Management and Stewardship of Airborne Observational Data for the NSF/NCAR HIAPER (GV) and NSF/NCAR C-130 at the National Center for Atmospheric Research (NCAR) Earth Observing Laboratory (EOL)

    NASA Astrophysics Data System (ADS)

    Aquino, J.

    2014-12-01

    The National Science Foundation (NSF) provides the National Center for Atmospheric Research (NCAR) Earth Observing Laboratory (EOL) funding for the operation, maintenance and upgrade of two research aircraft: the NSF/NCAR High-performance Instrumented Airborne Platform for Environmental Research (HIAPER) Gulfstream V and the NSF/NCAR Hercules C-130. A suite of in-situ and remote sensing airborne instruments housed at the EOL Research Aviation Facility (RAF) provide a basic set of measurements that are typically deployed on most airborne field campaigns. In addition, instruments to address more specific research requirements are provided by collaborating participants from universities, industry, NASA, NOAA or other agencies. The data collected are an important legacy of these field campaigns. A comprehensive metadata database and integrated cyber-infrastructure, along with a robust data workflow that begins during the field phase and extends to long-term archival (current aircraft data holdings go back to 1967), assures that: all data and associated software are safeguarded throughout the data handling process; community standards of practice for data stewardship and software version control are followed; simple and timely community access to collected data and associated software tools are provided; and the quality of the collected data is preserved, with the ultimate goal of supporting research and the reproducibility of published results. The components of this data system to be presented include: robust, searchable web access to data holdings; reliable, redundant data storage; web-based tools and scripts for efficient creation, maintenance and update of data holdings; access to supplemental data and documentation; storage of data in standardized data formats; comprehensive metadata collection; mature version control; human-discernable storage practices; and procedures to inform users of changes. In addition, lessons learned, shortcomings, and desired upgrades

  13. Methotrexate and Corticosteroids in the Treatment of Localized Scleroderma: A Standardized Prospective Longitudinal Single-center Study

    PubMed Central

    Torok, Kathryn S.; Arkachaisri, Thaschawee

    2013-01-01

    Objective To evaluate the effectiveness of a uniform single-center treatment protocol composed of high-dose methotrexate (MTX) and oral corticosteroids in a pediatric localized scleroderma (LS) cohort. Methods Thirty-six patients with LS were recruited. Patients with active disease, defined as erythematous lesions and/or new lesions, or expansion of existing lesions, were started on oral prednisone 2 mg/kg/day (maximum 60 mg/day) and subcutaneous (SC) MTX at 1 mg/kg/week (maximum 25 mg/week). Prednisone was tapered and kept at 0.25 mg/kg/day for 12 months. MTX SC was continued for 24 months, and then switched to oral administration to complete 36 months of therapy. Modified LS Skin Severity Index (mLoSSI) and the physician global assessment of disease activity (PGA-A) were used as outcome measures. Results Twenty-five patients with LS were female with a median age at onset of 7.86 years [interquartile range (IQR) 4.63–11.91]. Median disease duration from onset until start of this treatment regimen was 19.2 months (IQR 8.96–35.35). Median duration of followup was 36.40 months (IQR 29.39–45.36). All patients demonstrated significant improvement in mLoSSI at median 1.77 months (IQR 0.76–2.37, 95% CI 1.54, 2.01). PGA-A followed the same trend. No significant adverse reactions or flares were observed during therapy. Conclusion This single-center LS treatment protocol was effective and well tolerated. Clinical outcome in LS is affected by dose and route of administration of immunosuppressive regimens. Daily tapering dose of corticosteroids and parenteral MTX were effective in controlling LS activity without significant adverse reaction. This regimen should be considered as one of the therapies for LS clinical trials. PMID:22247357

  14. NPL secondary standard radionuclide calibrator. Syringe calibration factors for radionuclides used in nuclear medicine. National Physical Laboratory.

    PubMed

    Tyler, D K; Baker, M; Woods, M J

    2002-01-01

    The measurement of the activity of a radiopharmaceutical administration to a patient is normally achieved via the use of a radionuclide calibrator. Although these radionuclides are normally measured initially in a standard glass vial, an aliquot of the solution is then usually withdrawn into a syringe prior to the administration. Both for general quality assurance good practice and for additional guarantees for patient safety, a confirmatory measurement of the syringe is almost obligatory Because of the different geometries and elemental compositions between plastic syringes and glass vials, the calibration factors for syringes may well be significantly different from those for the glass containers. The magnitude of these differences depends on the energies of the emitted photons. A variety of syringes typically used in hospital administrations, and covering a range of volumes and manufacturers, were obtained. The results obtained were compared to those for glass vials and show the large errors that can be produced by ignoring these differences in container format.

  15. Laboratory-confirmed HIV and sexually transmitted infection seropositivity and risk behavior among sexually active transgender patients at an adolescent and young adult urban community health center.

    PubMed

    Reisner, Sari L; Vetters, Ralph; White, Jaclyn M; Cohen, Elijah L; LeClerc, M; Zaslow, Shayne; Wolfrum, Sarah; Mimiaga, Matthew J

    2015-01-01

    The sexual health of transgender adolescents and young adults who present for health care in urban community health centers is understudied. A retrospective review of electronic health record (EHR) data was conducted from 180 transgender patients aged 12-29 years seen for one or more health-care visits between 2001 and 2010 at an urban community health center serving youth in Boston, MA. Analyses were restricted to 145 sexually active transgender youth (87.3% of the sample). Laboratory-confirmed HIV and sexually transmitted infections (STIs) seroprevalence, demographics, sexual risk behavior, and structural and psychosocial risk indicators were extracted from the EHR. Analyses were descriptively focused for HIV and STIs. Stratified multivariable logistic regression models were fit for male-to-female (MTF) and female-to-male (FTM) patients separately to examine factors associated with any unprotected anal and/or vaginal sex (UAVS). The mean age was 20.0 (SD=2.9); 21.7% people of color, 46.9% white (non-Hispanic), 21.4% race/ethnicity unknown; 43.4% MTF, and 56.6% FTM; and 68.3% were on cross-sex hormones. Prevalence of STIs: 4.8% HIV, 2.8% herpes simplex virus, 2.8% syphilis, 2.1% chlamydia, 2.1% gonorrhea, 2.8% hepatitis C, 1.4% human papilloma virus. Only gonorrhea prevalence significantly differed by gender identity (MTF 2.1% vs. 0.0% FTM; p=0.046). Nearly half (47.6%) of the sample engaged in UAVS (52.4% MTF, 43.9% FTM, p=0.311). FTM more frequently had a primary sex partner compared to MTF (48.8% vs. 25.4%; p=0.004); MTF more frequently had a casual sex partner than FTM (69.8% vs. 42.7% p=0.001). In multivariable models, MTF youth who were younger in age, white non-Hispanic, and reported a primary sex partner had increased odds of UAVS; whereas, FTM youth reporting a casual sex partner and current alcohol use had increased odds of UAVS (all p<0.05). Factors associated with sexual risk differ for MTF and FTM youth. Partner type appears pivotal to understanding

  16. The standardized fish bioassay procedure for detecting and culturing actively toxic Pfiesteria, used by two reference laboratories for atlantic and gulf coast states.

    PubMed

    Burkholder, J M; Marshall, H G; Glasgow, H B; Seaborn, D W; Deamer-Melia, N J

    2001-10-01

    In the absence of purified standards of toxins from Pfiesteria species, appropriately conducted fish bioassays are the "gold standard" that must be used to detect toxic strains of Pfiesteria spp. from natural estuarine water or sediment samples and to culture actively toxic Pfiesteria. In this article, we describe the standardized steps of our fish bioassay as an abbreviated term for a procedure that includes two sets of trials with fish, following the Henle-Koch postulates modified for toxic rather than infectious agents. This procedure was developed in 1991, and has been refined over more than 12 years of experience in research with toxic Pfiesteria. The steps involve isolating toxic strains of Pfiesteria (or other potentially, as-yet-undetected, toxic Pfiesteria or Pfiesteria-like species) from fish-killing bioassays with natural samples; growing the clones with axenic algal prey; and retesting the isolates in a second set of fish bioassays. The specific environmental conditions used (e.g., temperature, salinity, light, other factors) must remain flexible, given the wide range of conditions from which natural estuarine samples are derived. We present a comparison of information provided for fish culture conditions, reported in international science journals in which such research is routinely published, and we provide information from more than 2,000 fish bioassays with toxic Pfiesteria, along with recommendations for suitable ranges and frequency of monitoring of environmental variables. We present data demonstrating that algal assays, unlike these standardized fish bioassays, should not be used to detect toxic strains of Pfiesteria spp. Finally, we recommend how quality control/assurance can be most rapidly advanced among laboratories engaged in studies that require research-quality isolates of toxic Pfiesteria spp.

  17. The standardized fish bioassay procedure for detecting and culturing actively toxic Pfiesteria, used by two reference laboratories for atlantic and gulf coast states.

    PubMed Central

    Burkholder, J M; Marshall, H G; Glasgow, H B; Seaborn, D W; Deamer-Melia, N J

    2001-01-01

    In the absence of purified standards of toxins from Pfiesteria species, appropriately conducted fish bioassays are the "gold standard" that must be used to detect toxic strains of Pfiesteria spp. from natural estuarine water or sediment samples and to culture actively toxic Pfiesteria. In this article, we describe the standardized steps of our fish bioassay as an abbreviated term for a procedure that includes two sets of trials with fish, following the Henle-Koch postulates modified for toxic rather than infectious agents. This procedure was developed in 1991, and has been refined over more than 12 years of experience in research with toxic Pfiesteria. The steps involve isolating toxic strains of Pfiesteria (or other potentially, as-yet-undetected, toxic Pfiesteria or Pfiesteria-like species) from fish-killing bioassays with natural samples; growing the clones with axenic algal prey; and retesting the isolates in a second set of fish bioassays. The specific environmental conditions used (e.g., temperature, salinity, light, other factors) must remain flexible, given the wide range of conditions from which natural estuarine samples are derived. We present a comparison of information provided for fish culture conditions, reported in international science journals in which such research is routinely published, and we provide information from more than 2,000 fish bioassays with toxic Pfiesteria, along with recommendations for suitable ranges and frequency of monitoring of environmental variables. We present data demonstrating that algal assays, unlike these standardized fish bioassays, should not be used to detect toxic strains of Pfiesteria spp. Finally, we recommend how quality control/assurance can be most rapidly advanced among laboratories engaged in studies that require research-quality isolates of toxic Pfiesteria spp. PMID:11677184

  18. A Standard Set of Value-Based Patient-Centered Outcomes for Breast Cancer: The International Consortium for Health Outcomes Measurement (ICHOM) Initiative.

    PubMed

    Ong, Wee Loon; Schouwenburg, Maartje G; van Bommel, Annelotte C M; Stowell, Caleb; Allison, Kim H; Benn, Karen E; Browne, John P; Cooter, Rodney D; Delaney, Geoff P; Duhoux, Francois P; Ganz, Patricia A; Hancock, Patricia; Jagsi, Reshma; Knaul, Felicia M; Knip, Anne M; Koppert, Linetta B; Kuerer, Henry M; McLaughin, Sarah; Mureau, Marc A M; Partridge, Ann H; Reid, Dereesa Purtell; Sheeran, Lisa; Smith, Thomas J; Stoutjesdijk, Mark J; Vrancken Peeters, Marie Jeanne T F D; Wengström, Yvonne; Yip, Cheng-Har; Saunders, Christobel

    2016-12-29

    A major challenge in value-based health care is the lack of standardized health outcomes measurements, hindering optimal monitoring and comparison of the quality of health care across different settings globally. The International Consortium for Health Outcomes Measurement (ICHOM) assembled a multidisciplinary international working group, comprised of 26 health care providers and patient advocates, to develop a standard set of value-based patient-centered outcomes for breast cancer (BC). The working group convened via 8 teleconferences and completed a follow-up survey after each meeting. A modified 2-round Delphi method was used to achieve consensus on the outcomes and case-mix variables to be included. Patient focus group meetings (8 early or metastatic BC patients) and online anonymized surveys of 1225 multinational BC patients and survivors were also conducted to obtain patients' input. The standard set encompasses survival and cancer control, and disutility of care (eg, acute treatment complications) outcomes, to be collected through administrative data and/or clinical records. A combination of multiple patient-reported outcomes measurement (PROM) tools is recommended to capture long-term degree of health outcomes. Selected case-mix factors were recommended to be collected at baseline. The ICHOM will endeavor to achieve wide buy-in of this set and facilitate its implementation in routine clinical practice in various settings and institutions worldwide.

  19. The role of European Federation of Clinical Chemistry and Laboratory Medicine Working Group for Preanalytical Phase in standardization and harmonization of the preanalytical phase in Europe.

    PubMed

    Cornes, Michael P; Church, Stephen; van Dongen-Lases, Edmée; Grankvist, Kjell; Guimarães, João T; Ibarz, Mercedes; Kovalevskaya, Svetlana; Kristensen, Gunn Bb; Lippi, Giuseppe; Nybo, Mads; Sprongl, Ludek; Sumarac, Zorica; Simundic, Ana-Maria

    2016-09-01

    Patient safety is a leading challenge in healthcare and from the laboratory perspective it is now well established that preanalytical errors are the major contributor to the overall rate of diagnostic and therapeutic errors. To address this, the European Federation of Clinical Chemistry and Laboratory Medicine Working Group for Preanalytical Phase (EFLM WG-PRE) was established to lead in standardization and harmonization of preanalytical policies and practices at a European level. One of the key activities of the WG-PRE is the organization of the biennial EFLM-BD conference on the preanalytical phase to provide a forum for National Societies (NS) to discuss their issues. Since 2012, a year after the first Preanalytical phase conference, there has been a rapid growth in the number of NS with a working group engaged in preanalytical phase activities and there are now at least 19 countries that have one. As a result of discussions with NS at the third conference held in March 2015 five key areas were identified as requiring harmonisation. These were test ordering, sample transport and storage, patient preparation, sampling procedures and management of unsuitable specimens. The article below summarises the work that has and will be done in these areas. The goal of this initiative is to ensure the EFLM WG-PRE produces work that meets the needs of the European laboratory medicine community. Progress made in the identified areas will be updated at the next preanalytical phase conference and show that we have produced guidance that has enhanced standardisation in the preanalytical phase and improved patient safety throughout Europe.

  20. Establishment of reference intervals for von Willebrand factor antigen and eight coagulation factors in a Korean population following the Clinical and Laboratory Standards Institute guidelines.

    PubMed

    Jang, Ja-Hyun; Seo, Ja-Young; Bang, Sung-Hwan; Park, In-Ae; Kim, Hee-Jin; Kim, Sun-Hee

    2010-04-01

    Establishment of reference intervals for coagulation molecules is important but is costly and sometimes not feasible. Since reference intervals from manufacturers or the literature are mostly out of date or involved Western populations, the authors determined reference intervals for VWF: Ag and eight factors in a Korean population. VWF: Ag, factor VIII (FVIII), FII, FV, FVII, FIX, FX, FXI, and FXII were determined in Korean individuals visiting for routine checkup following the CLSI (Clinical and Laboratory Standards Institute) guidelines. Reagents by Diagnostica Stago were used on the STA Compact Analyzer (Diagnostica Stago). Exclusion criteria were medical history or laboratory findings that could affect the factor levels. Influence of demographic factors was analyzed. Mean +/- 2 x SD or central 95 percentile was used, as appropriate. We obtained data from 266 adults for VWF: Ag, 371 adults for FVIII, and minimum 136 adults for the rest. Reference interval for VWF was 51-176% (52-155% in blood group O and 71-186% for non-O). Reference interval for FVIII was 64-197% (55-150% in O and 77-205% in non-O). Reference interval for FII was 77-121%, FV 81-160%, FVII 68-149%, FIX 67-154%, FX 69-126%, FXI 59-138%, and FXII 48-177%. The medians of VWF: Ag, FVIII, and FIX were significantly higher in the elderly group (> or =60 years). We established local reference intervals for VWF: Ag and eight coagulation factors in a Korean population according to the CLSI guidelines. Significantly, different reference intervals were obtained in blood group O vs. non-O for VWF: Ag and FVIII. The reference intervals obtained in this study could be adopted in other clinical laboratories after appropriate validation.