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Sample records for standards laboratory center

  1. Sandia National Laboratories Facilities Management and Operations Center Design Standards Manual

    SciTech Connect

    Peterson, Timothy L.

    2014-09-01

    At Sandia National Laboratories in New Mexico (SNL/NM), the design, construction, operation, and maintenance of facilities is guided by industry standards, a graded approach, and the systematic analysis of life cycle benefits received for costs incurred. The design of the physical plant must ensure that the facilities are "fit for use," and provide conditions that effectively, efficiently, and safely support current and future mission needs. In addition, SNL/NM applies sustainable design principles, using an integrated whole-building design approach, from site planning to facility design, construction, and operation to ensure building resource efficiency and the health and productivity of occupants. The safety and health of the workforce and the public, any possible effects on the environment, and compliance with building codes take precedence over project issues, such as performance, cost, and schedule. These design standards generally apply to all disciplines on all SNL/NM projects. Architectural and engineering design must be both functional and cost-effective. Facility design must be tailored to fit its intended function, while emphasizing low-maintenance, energy-efficient, and energy-conscious design. Design facilities that can be maintained easily, with readily accessible equipment areas, low maintenance, and quality systems. To promote an orderly and efficient appearance, architectural features of new facilities must complement and enhance the existing architecture at the site. As an Architectural and Engineering (A/E) professional, you must advise the Project Manager when this approach is prohibitively expensive. You are encouraged to use professional judgment and ingenuity to produce a coordinated interdisciplinary design that is cost-effective, easily contractible or buildable, high-performing, aesthetically pleasing, and compliant with applicable building codes. Close coordination and development of civil, landscape, structural, architectural, fire

  2. Primary Standards Laboratory report

    SciTech Connect

    Not Available

    1990-12-01

    Sandia National Laboratories operates the Primary Standards Laboratory (PSL) for the Department of Energy, Albuquerque Operations Office (DOE/AL). This report summarizes metrology activities that received emphasis in the first half of 1990 and provides information pertinent to the operation of the DOE/AL system-wide Standards and Calibration Program.

  3. Standards Laboratory environments

    SciTech Connect

    Braudaway, D.W.

    1990-09-01

    Standards Laboratory environments need to be carefully selected to meet the specific mission of each laboratory. The mission of the laboratory depends on the specific work supported, the measurement disciplines required and the level of uncertainty required in the measurements. This document reproduces the contents of the Sandia National Laboratories Primary Standards Laboratory Memorandum Number 3B (PSLM-3B) which was issued on May 16, 1988, under the auspices of the Department of Energy, Albuquerque Operations Office, to guide the laboratories of the Nuclear Weapons Complex in selecting suitable environments. Because of both general interest and specific interest in Standards Laboratory environments this document is being issued in a more available form. The purpose of this document is to provide guidance in selection of laboratory environments suitable for standards maintenance and calibration operations. It is not intended to mandate a specific environment for a specific calibration but to direct selection of the environment and to offer suggestions on how to extend precision in an existing and/or achievable (practical) environment. Although this documents pertains specifically to standards laboratories, it can be applied to any laboratory requiring environmental control.

  4. Sonication standard laboratory module

    DOEpatents

    Beugelsdijk, Tony; Hollen, Robert M.; Erkkila, Tracy H.; Bronisz, Lawrence E.; Roybal, Jeffrey E.; Clark, Michael Leon

    1999-01-01

    A standard laboratory module for automatically producing a solution of cominants from a soil sample. A sonication tip agitates a solution containing the soil sample in a beaker while a stepper motor rotates the sample. An aspirator tube, connected to a vacuum, draws the upper layer of solution from the beaker through a filter and into another beaker. This beaker can thereafter be removed for analysis of the solution. The standard laboratory module encloses an embedded controller providing process control, status feedback information and maintenance procedures for the equipment and operations within the standard laboratory module.

  5. Standards for laboratory accreditation.

    PubMed

    1982-12-01

    After years of review by all of the CAP resource and other committees and councils, the Commission on Laboratory Accreditation developed a revised Standards for Accreditation of Medical Laboratories (Last revision, 1974). They were approved by the House of Delegates and, in the February issue of Pathologist '82, comments were solicited from the entire membership. Presented in the following pages are the final Standards for Laboratory Accreditation, which the Board of Governors adopted as CAP policy at its Sept. 2-4 meeting in Traverse City, Mich.

  6. Dental Laboratory Technology Program Standards.

    ERIC Educational Resources Information Center

    Georgia Univ., Athens. Dept. of Vocational Education.

    This guide contains 45 program standards for the dental laboratory technology program conducted in technical institutes in Georgia. The dental laboratory technology program, either diploma or associate degree, is designed to ensure that students gain basic competence in the job skills needed for an entry-level employee in dental laboratory…

  7. [Quality standards for medical laboratories].

    PubMed

    Pascal, P; Beyerle, F

    2006-07-01

    In France, medical laboratories must engage a quality approach according to the standard guide de bonne exécution des analyses (GBEA) and, for hospital laboratories, according to the Agence nationale d'évaluation en santé (Anaes). Except the GBEA and the Anaes handbook, which are obligatory standards by regulations, the biologists can choose, for a complementary and voluntary quality process, between the standards ISO 9001, ISO 17025 or ISO 15189. Our aim is to shed light on the advantages of these five standards by realizing a comparative study of their requirements. This work enabled us to highlight a great number of similarities and to raise the characteristics of these five standards. According to their objectives, the biologists will choose a recognition of their quality management system with an ISO 9001 certification or a recognition extended to the technical skills with an ISO 17025 or ISO 15189 accreditation. The contents of these last two documents are rather close and both integrate requirements of the standard ISO 9001. The standard ISO 17025 is, at first sight, rather distant from the biological analysis, requiring many efforts of adaptation, just like the ISO 9001 standard. The standard ISO 15189 seems to be well adapted but more constraining seeing the details requirements level needed. It necessitates a perfect control of the preanalytical phase, which is difficult to acquire in a clinical framework where the biological fluids are not taken by the laboratory staff.

  8. Argonne's Laboratory computing center - 2007 annual report.

    SciTech Connect

    Bair, R.; Pieper, G. W.

    2008-05-28

    Argonne National Laboratory founded the Laboratory Computing Resource Center (LCRC) in the spring of 2002 to help meet pressing program needs for computational modeling, simulation, and analysis. The guiding mission is to provide critical computing resources that accelerate the development of high-performance computing expertise, applications, and computations to meet the Laboratory's challenging science and engineering missions. In September 2002 the LCRC deployed a 350-node computing cluster from Linux NetworX to address Laboratory needs for mid-range supercomputing. This cluster, named 'Jazz', achieved over a teraflop of computing power (1012 floating-point calculations per second) on standard tests, making it the Laboratory's first terascale computing system and one of the 50 fastest computers in the world at the time. Jazz was made available to early users in November 2002 while the system was undergoing development and configuration. In April 2003, Jazz was officially made available for production operation. Since then, the Jazz user community has grown steadily. By the end of fiscal year 2007, there were over 60 active projects representing a wide cross-section of Laboratory expertise, including work in biosciences, chemistry, climate, computer science, engineering applications, environmental science, geoscience, information science, materials science, mathematics, nanoscience, nuclear engineering, and physics. Most important, many projects have achieved results that would have been unobtainable without such a computing resource. The LCRC continues to foster growth in the computational science and engineering capability and quality at the Laboratory. Specific goals include expansion of the use of Jazz to new disciplines and Laboratory initiatives, teaming with Laboratory infrastructure providers to offer more scientific data management capabilities, expanding Argonne staff use of national computing facilities, and improving the scientific reach and

  9. Productivity standards for histology laboratories.

    PubMed

    Buesa, René J

    2010-04-01

    The information from 221 US histology laboratories (histolabs) and 104 from 24 other countries with workloads from 600 to 116 000 cases per year was used to calculate productivity standards for 23 technical and 27 nontechnical tasks and for 4 types of work flow indicators. The sample includes 254 human, 40 forensic, and 31 veterinary pathology services. Statistical analyses demonstrate that most productivity standards are not different between services or worldwide. The total workload for the US human pathology histolabs averaged 26 061 cases per year, with 54% between 10 000 and less than 30 000. The total workload for 70% of the histolabs from other countries was less than 20 000, with an average of 15 226 cases per year. The fundamental manual technical tasks in the histolab and their productivity standards are as follows: grossing (14 cases per hour), cassetting (54 cassettes per hour), embedding (50 blocks per hour), and cutting (24 blocks per hour). All the other tasks, each with their own productivity standards, can be completed by auxiliary staff or using automatic instruments. Depending on the level of automation of the histolab, all the tasks derived from a workload of 25 cases will require 15.8 to 17.7 hours of work completed by 2.4 to 2.7 employees with 18% of their working time not directly dedicated to the production of diagnostic slides. This article explains how to extrapolate this productivity calculation for any workload and different levels of automation. The overall performance standard for all the tasks, including 8 hours for automated tissue processing, is 3.2 to 3.5 blocks per hour; and its best indicator is the value of the gross work flow productivity that is essentially dependent on how the work is organized. This article also includes productivity standards for forensic and veterinary histolabs, but the staffing benchmarks for histolabs will be the subject of a separate article. Copyright 2010 Elsevier Inc. All rights reserved.

  10. Integration and standardization within the Mayo Foundation Laboratories: the centralized laboratory purchasing group.

    PubMed

    Hernandez, James S; Newton, Nancy C; O'Hara, Susan K

    2005-11-29

    Integration and standardization of laboratories throughout a medical system can increase the efficiency and effectiveness of laboratory operations. This task is challenging in most health-care systems, as no central governance exists to compel laboratories to standardize and integrate. We describe the initial collaborative efforts to integrate and standardize the laboratories of the Mayo Foundation, which includes more than 60 laboratories of different sizes in diverse locations. The goals and objectives of the group formed to develop this initiative--the Centralized Laboratory Purchasing Group--its origin, and lessons learned are described. Similar initiatives by other academic medical centers and community health-care systems to integrate and standardize their laboratories are discussed. Successful standardization and integration increases the value of the laboratory to the larger health-care system by demonstrating accountability, efficiency, and effectiveness, and can result in considerable cost savings to the entire health-care system.

  11. Research Laboratories and Centers Fact Sheet

    EPA Pesticide Factsheets

    The Office of Research and Development is the research arm of the U.S. Environmental Protection Agency. It has three national laboratories and four national centers located in 14 facilities across the country.

  12. OSHA Laboratory Standard: Driving Force for Laboratory Safety!

    ERIC Educational Resources Information Center

    Roy, Kenneth R.

    2000-01-01

    Discusses the Occupational Safety and Health Administration's (OSHA's) Laboratory Safety Standards as the major driving force in establishing and maintaining a safe working environment for teachers and students. (Author)

  13. OSHA Laboratory Standard: Driving Force for Laboratory Safety!

    ERIC Educational Resources Information Center

    Roy, Kenneth R.

    2000-01-01

    Discusses the Occupational Safety and Health Administration's (OSHA's) Laboratory Safety Standards as the major driving force in establishing and maintaining a safe working environment for teachers and students. (Author)

  14. Standardization of terminology in laboratory medicine II.

    PubMed

    Lee, Kap No; Yoon, Jong-Hyun; Min, Won Ki; Lim, Hwan Sub; Song, Junghan; Chae, Seok Lae; Jang, Seongsoo; Ki, Chang-Seok; Bae, Sook Young; Kim, Jang Su; Kwon, Jung-Ah; Lee, Chang Kyu; Yoon, Soo-Young

    2008-08-01

    Standardization of medical terminology is essential in data transmission between health care institutes and in maximizing the benefits of information technology. The purpose of this study was to standardize medical terms for laboratory observations. During the second year of the study, a standard database of concept names for laboratory terms that covered those used in tertiary health care institutes and reference laboratories was developed. The laboratory terms in the Logical Observation Identifier Names and Codes (LOINC) database were adopted and matched with the electronic data interchange (EDI) codes in Korea. A public hearing and a workshop for clinical pathologists were held to collect the opinions of experts. The Korean standard laboratory terminology database containing six axial concept names, components, property, time aspect, system (specimen), scale type, and method type, was established for 29,340 test observations. Short names and mapping tables for EDI codes and UMLS were added. Synonym tables were prepared to help match concept names to common terms used in the fields. We herein described the Korean standard laboratory terminology database for test names, result description terms, and result units encompassing most of the laboratory tests in Korea.

  15. Challenges of implementing Iranian national laboratory standards.

    PubMed

    Safadel, N; Dahim, P; Anjarani, S; Rahnamaye Farzami, M; Samiee, S Mirab; Amini, R; Farsi, Sh; Mahdavi, S; Khodaverdian, K; Rashed Marandi, F

    2013-01-01

    After four years of publishing the Iranian National Laboratory Standard and following a strategic plan to implement its requirements, it was decided to review the taken actions, evaluating the achievements and the failures, as well as analyzing the gaps and planning the interventional activities to resolve the problems. A thorough evaluation revealed that the progress of implementation process varies considerably in different provinces, as well as in laboratories in different public and private sectors. Diversity and heterogeneousity of laboratories throughout the country is one of unresolvable problems. Although we encounter shortage of resources in the country, improper allocation or distribution of resources and budgets make the problems more complicated. Inadequacy of academic training in laboratory sciences has resulted in necessity of holding comprehensive post-graduate training courses. Revising academic curriculum of laboratory sciences could be mostly helpful, moreover there should be organized, training courses with pre-determined practical topics. providing specific technical guidelines, to clarify the required technical details could temporarily fill the training gaps of laboratory staff. Inadequate number of competent auditors was one of the difficulties in universities. Another important challenge returns to laboratory equipment, developing the national controlling system to manage the laboratory equipment in terms of quality and accessibility has been planned in RHL. At last cultural problems and resistance to change are main obstacles that have reduced the pace of standardization, it needs to rationalize the necessity of establishing laboratory standards for all stakeholders.

  16. Certification standards transfer: from committee to laboratory.

    PubMed

    Lehmann, H P

    1998-12-01

    The ISO 9000 Standards series were developed to provide the international manufacturing industry with a framework to ensure purchased products meet quality criteria. Section 4 of ISO 9001, Quality System Model for Quality Assurance in Design, Development, Production, Installation and Servicing, contains 20 aspects of a quality system that must be addressed by an organization in order to receive ISO 9001 certification. This concept is extended to the clinical laboratory, where a quality system program establishes for the customer (patient/clinician) that the purchased product (requested information on a submitted specimen-test result) meets established quality norms. In order to satisfy the customer, the providing organization must have policies and procedures in place that ensure a quality product, and be certified. To become certified the organization must, through an inspection process, demonstrate to an independent accrediting agency that it meets defined standards. In the United States, the government through the Clinical Laboratory Improvement Amendment (CLIA) 1988 established quality standards for the clinical laboratory. The College of American Pathologists (CAP), through its Laboratory Accreditation Program (LAP), serves as an independent agency that certifies that laboratories meet standards. To demonstrate the applicability of an established clinical laboratory accreditation program to ISO 9001 certification, the standards and checklists of CLIA 1988 and the CAP LAP will be examined to determine their conformance to ISO 9001, Section 4.

  17. Metals Processing Laboratory User Center (MPLUS)

    SciTech Connect

    Mackiewicz-Ludtka, G.; Hayden, H.W.

    1997-04-01

    The Metals Processing Laboratory User (MPLUS) Center was officially designated as a DOE User Facility in February, 1996. It`s primary purpose is to assist researchers in key U.S. industries, universities, and federal laboratories in improving energy efficiency and enhancing U.S. competitiveness in the world market. The MPLUS Center provides users the unique opportunity to address technology-related issues to solve metals-processing problems from a fully integrated approach. DOE facilitates the process and catalyzes industrial interactions that enables technical synergy and financial leveraging to take place between the industrial sector identifying and prioritizing their technological needs, and MPLUS, which provides access to the technical expertise and specialized facilities to address these needs. MPLUS is designed to provide U.S. industries with access to the specialized technical expertise and equipment needed to solve metals-processing issues that limit the development and implementation of emerging metals-processing technologies. As originated, MPLUS includes the following four primary user centers: Metals Processing, Metals Joining, Metals Characterization, and Metals Process Modeling. These centers are devoted to assisting U.S. industries in adjusting to rapid changes in the marketplace and in improving products and processes. This approach optimizes the complementary strengths of industry and government. Tremendous industrial response, has resulted in MPLUS expanding to meet the ever-growing technical needs and requests initiated by U.S. industry.

  18. Calibration of the Standards and Calibration Laboratory`s Co{sup 60} Radiation Pool

    SciTech Connect

    Wirtenson, G.R.; White, R.H.

    1993-01-01

    The authors report measurements of dose rates at various locations in the LLNL Standards and Calibrations Laboratory`s Co{sup 60} Radiation Pool. Plots show the dependence of dose rate on radius near the bottom of the pool and the dependence of dose rate on height at a fixed distance from the pool center. The effect of varying sample location within the pool`s dry-well was also investigated.

  19. The need for standardization in laboratory networks.

    PubMed

    Peter, Trevor F; Shimada, Yoko; Freeman, Richard R; Ncube, Bekezela N; Khine, Aye-Aye; Murtagh, Maurine M

    2009-06-01

    Expanding health care services for HIV, tuberculosis, and malaria has increased the demand for affordable and reliable laboratory diagnostics in resource-limited countries. Many countries are responding by upgrading their public laboratories and introducing new technology to provide expanded testing services into more regions. This expansion carries the risk of increasing the diversity of an already highly diverse technology and testing platform landscape, making it more difficult to manage laboratory networks across different levels of the health care system. To prevent this trend, countries are recommended to implement policies and guidelines that standardize test menus, technology, platforms, and commodities across multiple laboratories. The benefits of standardization include rational prioritization of resources for capacity development and more efficient supply chain management through volume-based price discounts for reagents and instrument service. Procurement procedures, including specification, prequalification, and contract negotiation, need to align with the standardization policies for maximum benefit. Standardization should be adhered to irrespective of whether procurement is centralized or decentralized or whether carried out by national bodies or development partners.

  20. Technical activities 1986, Center for Basic Standards

    NASA Astrophysics Data System (ADS)

    Heydemann, P. L. M.

    1986-10-01

    The report summarizes the research and technical activities of the Center for Basic Standards during the Fiscal Year 1986. These activities include work in the areas of electricity, temperature and pressure, mass and length, time and frequency, quantum metrology, and quantum physics.

  1. Standardizing clinical laboratory data for secondary use.

    PubMed

    Abhyankar, Swapna; Demner-Fushman, Dina; McDonald, Clement J

    2012-08-01

    Clinical databases provide a rich source of data for answering clinical research questions. However, the variables recorded in clinical data systems are often identified by local, idiosyncratic, and sometimes redundant and/or ambiguous names (or codes) rather than unique, well-organized codes from standard code systems. This reality discourages research use of such databases, because researchers must invest considerable time in cleaning up the data before they can ask their first research question. Researchers at MIT developed MIMIC-II, a nearly complete collection of clinical data about intensive care patients. Because its data are drawn from existing clinical systems, it has many of the problems described above. In collaboration with the MIT researchers, we have begun a process of cleaning up the data and mapping the variable names and codes to LOINC codes. Our first step, which we describe here, was to map all of the laboratory test observations to LOINC codes. We were able to map 87% of the unique laboratory tests that cover 94% of the total number of laboratory tests results. Of the 13% of tests that we could not map, nearly 60% were due to test names whose real meaning could not be discerned and 29% represented tests that were not yet included in the LOINC table. These results suggest that LOINC codes cover most of laboratory tests used in critical care. We have delivered this work to the MIMIC-II researchers, who have included it in their standard MIMIC-II database release so that researchers who use this database in the future will not have to do this work. Published by Elsevier Inc.

  2. Standardizing clinical laboratory data for secondary use

    PubMed Central

    Demner-Fushman, Dina; McDonald, Clement J.

    2012-01-01

    Clinical databases provide a rich source of data for answering clinical research questions. However, the variables recorded in clinical data systems are often identified by local, idiosyncratic, and sometimes redundant and/or ambiguous names (or codes) rather than unique, well-organized codes from standard code systems. This reality discourages research use of such databases, because researchers must invest considerable time in cleaning up the data before they can ask their first research question. Researchers at MIT developed MIMIC-II, a nearly complete collection of clinical data about intensive care patients. Because its data are drawn from existing clinical systems, it has many of the problems described above. In collaboration with the MIT researchers, we have begun a process of cleaning up the data and mapping the variable names and codes to LOINC codes. Our first step, which we describe here, was to map all of the laboratory test observations to LOINC codes. We were able to map 87% of the unique laboratory tests that cover 94% of the total number of laboratory tests results. Of the 13% of tests that we could not map, nearly 60% were due to test names whose real meaning could not be discerned and 29% represented tests that were not yet included in the LOINC table. These results suggest that LOINC codes cover most of laboratory tests used in critical care. We have delivered this work to the MIMIC-II researchers, who have included it in their standard MIMIC-II database release so that researchers who use this database in the future will not have to do this work. PMID:22561944

  3. Argonne's Laboratory computing resource center : 2006 annual report.

    SciTech Connect

    Bair, R. B.; Kaushik, D. K.; Riley, K. R.; Valdes, J. V.; Drugan, C. D.; Pieper, G. P.

    2007-05-31

    Argonne National Laboratory founded the Laboratory Computing Resource Center (LCRC) in the spring of 2002 to help meet pressing program needs for computational modeling, simulation, and analysis. The guiding mission is to provide critical computing resources that accelerate the development of high-performance computing expertise, applications, and computations to meet the Laboratory's challenging science and engineering missions. In September 2002 the LCRC deployed a 350-node computing cluster from Linux NetworX to address Laboratory needs for mid-range supercomputing. This cluster, named 'Jazz', achieved over a teraflop of computing power (10{sup 12} floating-point calculations per second) on standard tests, making it the Laboratory's first terascale computing system and one of the 50 fastest computers in the world at the time. Jazz was made available to early users in November 2002 while the system was undergoing development and configuration. In April 2003, Jazz was officially made available for production operation. Since then, the Jazz user community has grown steadily. By the end of fiscal year 2006, there were 76 active projects on Jazz involving over 380 scientists and engineers. These projects represent a wide cross-section of Laboratory expertise, including work in biosciences, chemistry, climate, computer science, engineering applications, environmental science, geoscience, information science, materials science, mathematics, nanoscience, nuclear engineering, and physics. Most important, many projects have achieved results that would have been unobtainable without such a computing resource. The LCRC continues to foster growth in the computational science and engineering capability and quality at the Laboratory. Specific goals include expansion of the use of Jazz to new disciplines and Laboratory initiatives, teaming with Laboratory infrastructure providers to offer more scientific data management capabilities, expanding Argonne staff use of national

  4. 42 CFR 493.1445 - Standard; Laboratory director responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false Standard; Laboratory director responsibilities. 493... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1445 Standard; Laboratory...

  5. 42 CFR 493.1405 - Standard; Laboratory director qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false Standard; Laboratory director qualifications. 493... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity Testing § 493.1405 Standard; Laboratory...

  6. 42 CFR 493.1407 - Standard; Laboratory director responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false Standard; Laboratory director responsibilities. 493... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity Testing § 493.1407 Standard; Laboratory...

  7. 42 CFR 493.1445 - Standard; Laboratory director responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Standard; Laboratory director responsibilities. 493... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1445 Standard; Laboratory...

  8. 42 CFR 493.1407 - Standard; Laboratory director responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Standard; Laboratory director responsibilities. 493... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity Testing § 493.1407 Standard; Laboratory...

  9. Measurement performance of reagent manufacturers by Centers for Disease Control and Prevention/Cholesterol Reference Method Laboratory Network lipid standardization specified for metabolic syndrome-focused health checkups program in Japan.

    PubMed

    Nakamura, Masakazu; Koyama, Isao; Iso, Hiroyasu; Sato, Shinichi; Okazaki, Mitsuyo; Kiyama, Masahiko; Shimamoto, Takashi; Konishi, Masamitsu

    2009-01-01

    This study was designed to clarify the current measurement performance of 7 reagent manufacturers for high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC) and triglycerides (TG) specified for the metabolic syndrome (MetS)-focused health checkups program in Japan. Twenty HDLC, 21 LDLC and 9 TG analytical reagent/instrument/calibrator systems (system), and combinations of reagent lots, instrument models and calibrator lots, underwent Centers for Disease Control and Prevention (CDC)/Cholesterol Reference Method Laboratory Network (CRMLN) lipid standardization. Eighty and 100% systems were requested to achieve an accuracy of within +/-1% and +/-2% of the reference value, so that a clinical laboratory can meet the CDC criteria. The CDC performance criteria of HDLC, LDLC and TG require an accuracy of within +/-5%, +/-4% and +/-5%, respectively. For HDLC, all 20 systems met the criteria. Fourteen (70.0%) and 18 (90.0%) systems were within +/-1% and +/-2%, respectively. For LDLC, 14 (66.7%) of 21 systems met the criteria, but 7 (33.3%) failed. Five (23.8%) and 17 (81.0%) systems were within +/-1% and +/-2%, respectively. For TG, 8 of 9 systems met the criteria. Two (22.2%) and 4 (44.4%) systems were within +/-1% and +/-2%, respectively. The minimum and maximum differences of a specified sample among manufacturers were 1.6 and 11.0 mg/dL for HDLC, 7.8 and 33.0 mg/dL for LDLC, and 2.8 and 27.4 mg/dL for TG, respectively. Homogeneous HDLC methods are acceptable for MetS, but further accuracy improvement of homogeneous LDLC and TG methods will be needed because of their poor performance.

  10. Temporary Laboratory Office in Huntsville Industrial Center Building

    NASA Technical Reports Server (NTRS)

    1964-01-01

    Temporary quarters in the Huntsville Industrial Center (HIC) building located in downtown Huntsville, Alabama, as Marshall Space Flight Center (MSFC) grew. This image shows drafting specialists from the Propulsion and Vehicle Engineering Laboratory at work in the HIC building.

  11. The OSHA hazardous chemical occupational exposure standard for laboratories.

    PubMed

    Armbruster, D A

    1991-01-01

    OSHA's chemical occupational exposure standard for laboratories is an outgrowth of the previously issued Hazard Communication Standard. The standard relieves laboratories from complying with general industry standards but does require compliance with specific laboratory guidelines. The heart of the standard is the creation of a Chemical Hygiene Plan (CHP). The CHP addresses major issues such as safety equipment and procedures, work practices, training, the designation of a chemical hygiene officer, and the provision of medical consultation and examination for affected employees. This new standard, in full effect as of January 31, 1991, presents yet another regulatory challenge to laboratory managers but also ensures a safer environment for laboratory workers.

  12. Argonne's Laboratory Computing Resource Center : 2005 annual report.

    SciTech Connect

    Bair, R. B.; Coghlan, S. C; Kaushik, D. K.; Riley, K. R.; Valdes, J. V.; Pieper, G. P.

    2007-06-30

    Argonne National Laboratory founded the Laboratory Computing Resource Center in the spring of 2002 to help meet pressing program needs for computational modeling, simulation, and analysis. The guiding mission is to provide critical computing resources that accelerate the development of high-performance computing expertise, applications, and computations to meet the Laboratory's challenging science and engineering missions. The first goal of the LCRC was to deploy a mid-range supercomputing facility to support the unmet computational needs of the Laboratory. To this end, in September 2002, the Laboratory purchased a 350-node computing cluster from Linux NetworX. This cluster, named 'Jazz', achieved over a teraflop of computing power (10{sup 12} floating-point calculations per second) on standard tests, making it the Laboratory's first terascale computing system and one of the fifty fastest computers in the world at the time. Jazz was made available to early users in November 2002 while the system was undergoing development and configuration. In April 2003, Jazz was officially made available for production operation. Since then, the Jazz user community has grown steadily. By the end of fiscal year 2005, there were 62 active projects on Jazz involving over 320 scientists and engineers. These projects represent a wide cross-section of Laboratory expertise, including work in biosciences, chemistry, climate, computer science, engineering applications, environmental science, geoscience, information science, materials science, mathematics, nanoscience, nuclear engineering, and physics. Most important, many projects have achieved results that would have been unobtainable without such a computing resource. The LCRC continues to improve the computational science and engineering capability and quality at the Laboratory. Specific goals include expansion of the use of Jazz to new disciplines and Laboratory initiatives, teaming with Laboratory infrastructure providers to develop

  13. Putting the Laboratory at the Center of Teaching Chemistry

    ERIC Educational Resources Information Center

    Bopegedera, A. M. R. P.

    2011-01-01

    This article describes an effective approach to teaching chemistry by bringing the laboratory to the center of teaching, to bring the excitement of discovery to the learning process. The lectures and laboratories are closely integrated to provide a holistic learning experience. The laboratories progress from verification to open-inquiry and…

  14. HEW to Set Laboratory Safety Standards.

    ERIC Educational Resources Information Center

    Chemical and Engineering News, 1978

    1978-01-01

    Describes Department of Health, Education and Welfare (HEW) proposed guidelines for laboratories using chemical carcinogens. The guidelines are designed to provide protection for laboratory workers and their environment from exposure to all types of carcinogenic agents. (GA)

  15. HEW to Set Laboratory Safety Standards.

    ERIC Educational Resources Information Center

    Chemical and Engineering News, 1978

    1978-01-01

    Describes Department of Health, Education and Welfare (HEW) proposed guidelines for laboratories using chemical carcinogens. The guidelines are designed to provide protection for laboratory workers and their environment from exposure to all types of carcinogenic agents. (GA)

  16. 42 CFR 493.1359 - Standard; PPM laboratory director responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false Standard; PPM laboratory director responsibilities... AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Provider-Performed Microscopy (ppm) Procedures § 493.1359...

  17. 42 CFR 493.1359 - Standard; PPM laboratory director responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Standard; PPM laboratory director responsibilities... AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Provider-Performed Microscopy (ppm) Procedures § 493.1359...

  18. 42 CFR 493.1357 - Standard; laboratory director qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Standard; laboratory director qualifications. 493... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Provider-Performed Microscopy (ppm) Procedures § 493.1357...

  19. 42 CFR 493.1359 - Standard; PPM laboratory director responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Standard; PPM laboratory director responsibilities... AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Provider-Performed Microscopy (ppm) Procedures § 493.1359...

  20. 42 CFR 493.1357 - Standard; laboratory director qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false Standard; laboratory director qualifications. 493... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Provider-Performed Microscopy (ppm) Procedures § 493.1357...

  1. 42 CFR 493.1357 - Standard; laboratory director qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 5 2014-10-01 2014-10-01 false Standard; laboratory director qualifications. 493... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Provider-Performed Microscopy (ppm) Procedures § 493.1357...

  2. 42 CFR 493.1357 - Standard; laboratory director qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Standard; laboratory director qualifications. 493... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Provider-Performed Microscopy (ppm) Procedures § 493.1357...

  3. 42 CFR 493.1357 - Standard; laboratory director qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Standard; laboratory director qualifications. 493... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Provider-Performed Microscopy (ppm) Procedures § 493.1357...

  4. 42 CFR 493.1359 - Standard; PPM laboratory director responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Standard; PPM laboratory director responsibilities... AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Provider-Performed Microscopy (ppm) Procedures § 493.1359...

  5. 2. CATCH BASIN, INFLOW PIPES AT CENTER, COLD FLOW LABORATORY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. CATCH BASIN, INFLOW PIPES AT CENTER, COLD FLOW LABORATORY AT LEFT, VIEW TOWARDS NORTHWEST. - Glenn L. Martin Company, Titan Missile Test Facilities, Catch Basin, Waterton Canyon Road & Colorado Highway 121, Lakewood, Jefferson County, CO

  6. The Hydrogen Technology Center at Wyle Laboratories

    NASA Astrophysics Data System (ADS)

    Wheelock, H.; Smith, D.; Frazier, J.

    1990-10-01

    A deactivated storable propellant test area with numerous test cells, large open concrete pads of up to 65-ft length, and two enclosed metal storage buildings, has been converted into a Hydrogen Technology Center. The conversion strategy involved extensive use of modified surplus equipment, well established testing technologies, and innovative engineering to obviate long-delivery time items. Simple, high heat flux water-to-cryogen heat exchangers are used to generate ambient temperature H2 and N gas. Hydrogen-fueled combustors were designed and fabricated to power the specialized heat exchangers required to support high-temperature hydrogen experiments. The facility has operated productively and safely since October, 1988.

  7. VIEW OF THE INTERIOR OF BUILDING 125, THE STANDARDS LABORATORY. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF THE INTERIOR OF BUILDING 125, THE STANDARDS LABORATORY. THE PRIMARY FUNCTION OF THE STANDARDS LABORATORY WAS TO ENSURE AND IMPLEMENT A SYSTEM OF QUALITY CONTROL FOR INCOMING MATERIALS USED IN MANUFACTURING PROCESSES. SEVERAL ENGINEERING CONTROLS WERE USED TO ASSURE ACCURACY OF THE CALIBRATION PROCESSES INCLUDING: FLEX-FREE GRANITE TABLES, AIR LOCKED DOORS, TEMPERATURE CONTROLS, AND A SUPER-CLEAN ENVIRONMENT - Rocky Flats Plant, Standards Laboratory, Immediately north of 215A water tower & adjacent to Third Street, Golden, Jefferson County, CO

  8. Precision Laboratory Standards of Mass and Laboratory Weights

    DTIC Science & Technology

    1954-08-20

    Preferred denominations for laboratory weights Classes P. Q, and T Classes 11 and Q Class 1P Metric Avoirdupois Apothecary Troy Grain Carat kg l. 0Z 0...I g., or 500 ing 10 IngAvorduoi.--------------------------------------8, 4, 2, or 1 11), or S oz I j; oz5 Apothecary ...jeceiiUte Assay toni (29.1667 g) ----- ----- T’ Carat (200 nig) - - - - - - - - - - D~rain, apothecaries ’- -(-- ---- - Ir ap G rain

  9. Assessment of Tutoring Laboratories in a Learning Assistance Center

    ERIC Educational Resources Information Center

    Fullmer, Patricia

    2012-01-01

    The Learning Resource Center at Lincoln University, Pennsylvania, provides tutoring laboratories that are required for developmental reading, writing, and math courses. This article reviews the processes used to plan and determine the effectiveness of the tutoring laboratories, including logic models, student learning outcomes, and the results of…

  10. 42 CFR 493.1777 - Standard: Inspection of laboratories that have requested or have been issued a certificate of...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Standard: Inspection of laboratories that have requested or have been issued a certificate of compliance. 493.1777 Section 493.1777 Public Health CENTERS... CERTIFICATION LABORATORY REQUIREMENTS Inspection § 493.1777 Standard: Inspection of laboratories that...

  11. 42 CFR 493.1777 - Standard: Inspection of laboratories that have requested or have been issued a certificate of...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Standard: Inspection of laboratories that have requested or have been issued a certificate of compliance. 493.1777 Section 493.1777 Public Health CENTERS... CERTIFICATION LABORATORY REQUIREMENTS Inspection § 493.1777 Standard: Inspection of laboratories that...

  12. 42 CFR 493.1777 - Standard: Inspection of laboratories that have requested or have been issued a certificate of...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 5 2014-10-01 2014-10-01 false Standard: Inspection of laboratories that have requested or have been issued a certificate of compliance. 493.1777 Section 493.1777 Public Health CENTERS... CERTIFICATION LABORATORY REQUIREMENTS Inspection § 493.1777 Standard: Inspection of laboratories that...

  13. 42 CFR 493.1777 - Standard: Inspection of laboratories that have requested or have been issued a certificate of...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false Standard: Inspection of laboratories that have requested or have been issued a certificate of compliance. 493.1777 Section 493.1777 Public Health CENTERS... CERTIFICATION LABORATORY REQUIREMENTS Inspection § 493.1777 Standard: Inspection of laboratories that...

  14. 42 CFR 493.1777 - Standard: Inspection of laboratories that have requested or have been issued a certificate of...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Standard: Inspection of laboratories that have requested or have been issued a certificate of compliance. 493.1777 Section 493.1777 Public Health CENTERS... CERTIFICATION LABORATORY REQUIREMENTS Inspection § 493.1777 Standard: Inspection of laboratories that...

  15. VIEW TO EAST OF CRYSTALLIZATION LABORATORY (CENTER LEFT FOREGROUND), PAINT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW TO EAST OF CRYSTALLIZATION LABORATORY (CENTER LEFT FOREGROUND), PAINT APPLICATION BUILDING (CENTER BACKGROUND), AND c1944-1950 c1944-1950 POST-U.S. RADIUM ADDITION ADDITIONS TO EACH BUILDING (RIGHT FOREGROUND AND BACKGROUND) - United States Radium Corporation, 422-432 Alden Street, Orange, Essex County, NJ

  16. Establishment of national laboratory standards in public and private hospital laboratories.

    PubMed

    Anjarani, Soghra; Safadel, Nooshafarin; Dahim, Parisa; Amini, Rana; Mahdavi, Saeed; Mirab Samiee, Siamak

    2013-01-01

    In September 2007 national standard manual was finalized and officially announced as the minimal quality requirements for all medical laboratories in the country. Apart from auditing laboratories, Reference Health Laboratory has performed benchmarking auditing of medical laboratory network (surveys) in provinces. 12(th) benchmarks performed in Tehran and Alborz provinces, Iran in 2010 in three stages. We tried to compare different processes, their quality and accordance with national standard measures between public and private hospital laboratories. The assessment tool was a standardized checklist consists of 164 questions. Analyzing process show although in most cases implementing the standard requirements are more prominent in private laboratories, there is still a long way to complete fulfillment of requirements, and it takes a lot of effort. Differences between laboratories in public and private sectors especially in laboratory personnel and management process are significant. Probably lack of motivation, plays a key role in obtaining less desirable results in laboratories in public sectors.

  17. Establishment of National Laboratory Standards in Public and Private Hospital Laboratories

    PubMed Central

    ANJARANI, Soghra; SAFADEL, Nooshafarin; DAHIM, Parisa; AMINI, Rana; MAHDAVI, Saeed; MIRAB SAMIEE, Siamak

    2013-01-01

    In September 2007 national standard manual was finalized and officially announced as the minimal quality requirements for all medical laboratories in the country. Apart from auditing laboratories, Reference Health Laboratory has performed benchmarking auditing of medical laboratory network (surveys) in provinces. 12th benchmarks performed in Tehran and Alborz provinces, Iran in 2010 in three stages. We tried to compare different processes, their quality and accordance with national standard measures between public and private hospital laboratories. The assessment tool was a standardized checklist consists of 164 questions. Analyzing process show although in most cases implementing the standard requirements are more prominent in private laboratories, there is still a long way to complete fulfillment of requirements, and it takes a lot of effort. Differences between laboratories in public and private sectors especially in laboratory personnel and management process are significant. Probably lack of motivation, plays a key role in obtaining less desirable results in laboratories in public sectors. PMID:23514840

  18. Standard terminology in the laboratory and classroom

    NASA Technical Reports Server (NTRS)

    Strehlow, Richard A.

    1992-01-01

    Each of the materials produced by modern technologists is associated with a family of immaterials--all the concepts of substance, process, and purpose. It is concepts that are essential to transfer knowledge. It is concepts that are the stuff of terminology. Terminology is standardized today by companies, standards organizations, governments, and other groups. Simply described, it is the pre-negotiation of the meanings of terms. Terminology has become a key issue in businesses, and terminology knowledge is essential in understanding the modern world. The following is a introductory workshop discussing the concepts of terminology and methods of its standardization.

  19. 42 CFR 493.1443 - Standard; Laboratory director qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... least one year of laboratory training during medical residency (for example, physicians certified either... earned doctoral degree in a chemical, physical, biological, or clinical laboratory science from an... 42 Public Health 5 2010-10-01 2010-10-01 false Standard; Laboratory director qualifications. 493...

  20. Primary standards laboratory report, 1st half 1994

    SciTech Connect

    Not Available

    1994-11-01

    Sandia National Laboratories operates the Primary Standards Laboratory for the Department of Energy, Albuquerque Operations Office (DOE/AL). This report summarizes metrology activities that received emphasis in the first half of 1994 and provides information pertinent to the operation of the DOE/AL system-wide Standards and Calibration Program.

  1. Radioxenon standards used in laboratory inter-comparisons.

    PubMed

    Gohla, H; Auer, M; Cassette, Ph; Hague, R K; Lechermann, M; Nadalut, B

    2016-03-01

    Preparation methods for (133)Xe standards of activity concentration and the results of the 2014 (133)Xe laboratory inter-comparison exercise are described. One element of the quality assurance/quality control (QA/QC) program for laboratories of the International Monitoring System (IMS) will be regular inter-comparison exercises. However, until recently, no activity concentration standards for benchmarking were available. Therefore, two (133)Xe activity concentration reference standards were produced independently by Idaho National Laboratory and Seibersdorf Laboratories and used for the 2014 laboratory inter-comparison exercise. The preparation of a complementary (127)Xe activity concentration standard as well as a (127)Xe laboratory inter-comparison exercise suggests (127)Xe as a suitable isotope for QA/QC of remote IMS noble gas stations. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. Standardizing global gene expression analysis between laboratories and across platforms.

    PubMed

    Bammler, Theodore; Beyer, Richard P; Bhattacharya, Sanchita; Boorman, Gary A; Boyles, Abee; Bradford, Blair U; Bumgarner, Roger E; Bushel, Pierre R; Chaturvedi, Kabir; Choi, Dongseok; Cunningham, Michael L; Deng, Shibing; Dressman, Holly K; Fannin, Rickie D; Farin, Fredrico M; Freedman, Jonathan H; Fry, Rebecca C; Harper, Angel; Humble, Michael C; Hurban, Patrick; Kavanagh, Terrance J; Kaufmann, William K; Kerr, Kathleen F; Jing, Li; Lapidus, Jodi A; Lasarev, Michael R; Li, Jianying; Li, Yi-Ju; Lobenhofer, Edward K; Lu, Xinfang; Malek, Renae L; Milton, Sean; Nagalla, Srinivasa R; O'malley, Jean P; Palmer, Valerie S; Pattee, Patrick; Paules, Richard S; Perou, Charles M; Phillips, Ken; Qin, Li-Xuan; Qiu, Yang; Quigley, Sean D; Rodland, Matthew; Rusyn, Ivan; Samson, Leona D; Schwartz, David A; Shi, Yan; Shin, Jung-Lim; Sieber, Stella O; Slifer, Susan; Speer, Marcy C; Spencer, Peter S; Sproles, Dean I; Swenberg, James A; Suk, William A; Sullivan, Robert C; Tian, Ru; Tennant, Raymond W; Todd, Signe A; Tucker, Charles J; Van Houten, Bennett; Weis, Brenda K; Xuan, Shirley; Zarbl, Helmut

    2005-05-01

    To facilitate collaborative research efforts between multi-investigator teams using DNA microarrays, we identified sources of error and data variability between laboratories and across microarray platforms, and methods to accommodate this variability. RNA expression data were generated in seven laboratories, which compared two standard RNA samples using 12 microarray platforms. At least two standard microarray types (one spotted, one commercial) were used by all laboratories. Reproducibility for most platforms within any laboratory was typically good, but reproducibility between platforms and across laboratories was generally poor. Reproducibility between laboratories increased markedly when standardized protocols were implemented for RNA labeling, hybridization, microarray processing, data acquisition and data normalization. Reproducibility was highest when analysis was based on biological themes defined by enriched Gene Ontology (GO) categories. These findings indicate that microarray results can be comparable across multiple laboratories, especially when a common platform and set of procedures are used.

  3. Intercomparison of Laboratory Radiance Calibration Standards

    NASA Technical Reports Server (NTRS)

    Pavri, Betina; Chrien, Tom; Green, Robert; Williams, Orlesa

    2000-01-01

    Several standards for radiometric calibration were measured repeatedly with a spectroradiometer in order to understand how they compared in accuracy and stability. The tested radiance standards included a NIST 1000 W bulb and halon panel, two calibrated and stabilized integrating spheres, and a cavity blackbody. Results indicate good agreement between the blackbody and 1000 W bulb/spectralon panel, If these two radiance sources are assumed correct, then the integrating spheres did not conform. to their manufacturer-reported radiances in several regions of the spectrum. More detailed measurements am underway to investigate the discrepancy.

  4. Internship at NASA Kennedy Space Center's Cryogenic Test laboratory

    NASA Technical Reports Server (NTRS)

    Holland, Katherine

    2013-01-01

    NASA's Kennedy Space Center (KSC) is known for hosting all of the United States manned rocket launches as well as many unmanned launches at low inclinations. Even though the Space Shuttle recently retired, they are continuing to support unmanned launches and modifying manned launch facilities. Before a rocket can be launched, it has to go through months of preparation, called processing. Pieces of a rocket and its payload may come in from anywhere in the nation or even the world. The facilities all around the center help integrate the rocket and prepare it for launch. As NASA prepares for the Space Launch System, a rocket designed to take astronauts beyond Low Earth Orbit throughout the solar system, technology development is crucial for enhancing launch capabilities at the KSC. The Cryogenics Test Laboratory at Kennedy Space Center greatly contributes to cryogenic research and technology development. The engineers and technicians that work there come up with new ways to efficiently store and transfer liquid cryogens. NASA has a great need for this research and technology development as it deals with cryogenic liquid hydrogen and liquid oxygen for rocket fuel, as well as long term space flight applications. Additionally, in this new era of space exploration, the Cryogenics Test Laboratory works with the commercial sector. One technology development project is the Liquid Hydrogen (LH2) Ground Operations Demonstration Unit (GODU). LH2 GODU intends to demonstrate increased efficiency in storing and transferring liquid hydrogen during processing, loading, launch and spaceflight of a spacecraft. During the Shuttle Program, only 55% of hydrogen purchased was used by the Space Shuttle Main Engines. GODU's goal is to demonstrate that this percentage can be increased to 75%. Figure 2 shows the GODU layout when I concluded my internship. The site will include a 33,000 gallon hydrogen tank (shown in cyan) with a heat exchanger inside the hydrogen tank attached to a

  5. Clinical Laboratories – Production Factories or Specialized Diagnostic Centers

    PubMed Central

    Tóth, Judit

    2016-01-01

    Since a large proportion of medical decisions are based on laboratory results, clinical laboratories should meet the increasing demand of clinicians and their patients. Huge central laboratories may process over 10 million tests annually; they act as production factories, measuring emergency and routine tests with sufficient speed and accuracy. At the same time, they also serve as specialized diagnostic centers where well-trained experts analyze and interpret special test results. It is essential to improve and constantly monitor this complex laboratory service, by several methods. Sample transport by pneumatic tube system, use of an advanced laboratory information system and point-of-care testing may result in decreased total turnaround time. The optimization of test ordering may result in a faster and more cost-effective laboratory service. Autovalidation can save time for laboratory specialists, when the analysis of more complex results requires their attention. Small teams of experts responsible for special diagnostic work, and their interpretative reporting according to predetermined principles, may help to minimize subjectivity of these special reports. Although laboratory investigations have become so diversely developed in the past decades, it is essential that the laboratory can provide accurate results relatively quickly, and that laboratory specialists can support the diagnosis and monitoring of patients by adequate interpretation of esoteric laboratory methods. PMID:27683528

  6. [Accreditation of clinical laboratories based on ISO standards].

    PubMed

    Kawai, Tadashi

    2004-11-01

    International Organization for Standardization (ISO) have published two international standards (IS) to be used for accreditation of clinical laboratories; ISO/IEC 17025:1999 and ISO 15189:2003. Any laboratory accreditation body must satisfy the requirements stated in ISO/IEC Guide 58. In order to maintain the quality of the laboratory accreditation bodies worldwide, the International Laboratory Accreditation Cooperation (ILAC) has established the mutual recognition arrangement (MRA). In Japan, the International Accreditation Japan (IAJapan) and the Japan Accreditation Board for Conformity Assessment (JAB) are the members of the ILAC/MRA group. In 2003, the Japanese Committee for Clinical Laboratory Standards (JCCLS) and the JAB have established the Development Committee of Clinical Laboratory Accreditation Program (CLAP), in order to establish the CLAP, probably starting in 2005.

  7. U.S. Ebola Treatment Center Clinical Laboratory Support.

    PubMed

    Jelden, Katelyn C; Iwen, Peter C; Herstein, Jocelyn J; Biddinger, Paul D; Kraft, Colleen S; Saiman, Lisa; Smith, Philip W; Hewlett, Angela L; Gibbs, Shawn G; Lowe, John J

    2016-04-01

    Fifty-five hospitals in the United States have been designated Ebola treatment centers (ETCs) by their state and local health authorities. Designated ETCs must have appropriate plans to manage a patient with confirmed Ebola virus disease (EVD) for the full duration of illness and must have these plans assessed through a CDC site visit conducted by an interdisciplinary team of subject matter experts. This study determined the clinical laboratory capabilities of these ETCs. ETCs were electronically surveyed on clinical laboratory characteristics. Survey responses were returned from 47 ETCs (85%). Forty-one (87%) of the ETCs planned to provide some laboratory support (e.g., point-of-care [POC] testing) within the room of the isolated patient. Forty-four (94%) ETCs indicated that their hospital would also provide clinical laboratory support for patient care. Twenty-two (50%) of these ETC clinical laboratories had biosafety level 3 (BSL-3) containment. Of all respondents, 34 (72%) were supported by their jurisdictional public health laboratory (PHL), all of which had available BSL-3 laboratories. Overall, 40 of 44 (91%) ETCs reported BSL-3 laboratory support via their clinical laboratory and/or PHL. This survey provided a snapshot of the laboratory support for designated U.S. ETCs. ETCs have approached high-level isolation critical care with laboratory support in close proximity to the patient room and by distributing laboratory support among laboratory resources. Experts might review safety considerations for these laboratory testing/diagnostic activities that are novel in the context of biocontainment care. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

  8. U.S. Ebola Treatment Center Clinical Laboratory Support

    PubMed Central

    Jelden, Katelyn C.; Iwen, Peter C.; Herstein, Jocelyn J.; Biddinger, Paul D.; Kraft, Colleen S.; Saiman, Lisa; Smith, Philip W.; Hewlett, Angela L.; Gibbs, Shawn G.

    2016-01-01

    Fifty-five hospitals in the United States have been designated Ebola treatment centers (ETCs) by their state and local health authorities. Designated ETCs must have appropriate plans to manage a patient with confirmed Ebola virus disease (EVD) for the full duration of illness and must have these plans assessed through a CDC site visit conducted by an interdisciplinary team of subject matter experts. This study determined the clinical laboratory capabilities of these ETCs. ETCs were electronically surveyed on clinical laboratory characteristics. Survey responses were returned from 47 ETCs (85%). Forty-one (87%) of the ETCs planned to provide some laboratory support (e.g., point-of-care [POC] testing) within the room of the isolated patient. Forty-four (94%) ETCs indicated that their hospital would also provide clinical laboratory support for patient care. Twenty-two (50%) of these ETC clinical laboratories had biosafety level 3 (BSL-3) containment. Of all respondents, 34 (72%) were supported by their jurisdictional public health laboratory (PHL), all of which had available BSL-3 laboratories. Overall, 40 of 44 (91%) ETCs reported BSL-3 laboratory support via their clinical laboratory and/or PHL. This survey provided a snapshot of the laboratory support for designated U.S. ETCs. ETCs have approached high-level isolation critical care with laboratory support in close proximity to the patient room and by distributing laboratory support among laboratory resources. Experts might review safety considerations for these laboratory testing/diagnostic activities that are novel in the context of biocontainment care. PMID:26842705

  9. Highlighting High Performance Buildings: National Renewable Energy Laboratory's Visitors Center

    SciTech Connect

    2001-06-01

    The National Renewable Energy Laboratory Visitors Center, also known as the Dan Schaefer Federal Building, is a high-performance building located in Golden, Colorado. The 6,400-square-foot building incorporates passive solar heating, energy-efficient lighting, an evaporative cooling system, and other technologies to minimize energy costs and environmental impact. The Visitors Center displays a variety of interactive exhibits on energy efficiency and renewable energy, and the building includes an auditorium, a public reading room, and office space.

  10. Transfer Standard Uncertainty Can Cause Inconclusive Inter-Laboratory Comparisons.

    PubMed

    Wright, John; Toman, Blaza; Mickan, Bodo; Wübbeler, Gerd; Bodnar, Olha; Elster, Clemens

    2016-12-01

    Inter-laboratory comparisons use the best available transfer standards to check the participants' uncertainty analyses, identify underestimated uncertainty claims or unknown measurement biases, and improve the global measurement system. For some measurands, instability of the transfer standard can lead to an inconclusive comparison result. If the transfer standard uncertainty is large relative to a participating laboratory's uncertainty, the commonly used standardized degree of equivalence ≤ 1 criterion does not always correctly assess whether a participant is working within their uncertainty claims. We show comparison results that demonstrate this issue and propose several criteria for assessing a comparison result as passing, failing, or inconclusive. We investigate the behavior of the standardized degree of equivalence and alternative comparison measures for a range of values of the transfer standard uncertainty relative to the individual laboratory uncertainty values. The proposed alternative criteria successfully discerned between passing, failing, and inconclusive comparison results for the cases we examined.

  11. The Naval Health Research Center Respiratory Disease Laboratory.

    PubMed

    Ryan, M; Gray, G; Hawksworth, A; Malasig, M; Hudspeth, M; Poddar, S

    2000-07-01

    Concern about emerging and reemerging respiratory pathogens prompted the development of a respiratory disease reference laboratory at the Naval Health Research Center. Professionals working in this laboratory have instituted population-based surveillance for pathogens that affect military trainees and responded to threats of increased respiratory disease among high-risk military groups. Capabilities of this laboratory that are unique within the Department of Defense include adenovirus testing by viral shell culture and microneutralization serotyping, influenza culture and hemagglutination inhibition serotyping, and other special testing for Streptococcus pneumoniae, Streptococcus pyogenes, Mycoplasma pneumonia, and Chlamydia pneumoniae. Projected capabilities of this laboratory include more advanced testing for these pathogens and testing for other emerging pathogens, including Bordetella pertussis, Legionella pneumoniae, and Haemophilus influenzae type B. Such capabilities make the laboratory a valuable resource for military public health.

  12. NATIONAL ENVIRONMENTAL LABORATORY ACCREDITATION CONFERENCE (NELAC): CONSTITUTION, BYLAWS, AND STANDARDS

    EPA Science Inventory

    The principles and operating procedures for the National Environmental Laboratory Accreditation Conference (NELAC) are contained in the NELAC Constitution and Bylaws. The major portion of this document (standards) contains detailed requirements for accrediting environmental labo...

  13. NATIONAL ENVIRONMENTAL LABORATORY ACCREDITATION CONFERENCE (NELAC): CONSTITUTION, BYLAWS, AND STANDARDS

    EPA Science Inventory

    The principles and operating procedures for the National Environmental Laboratory Accreditation Conference (NELAC) are contained in the NELAC Constitution and Bylaws. The major portion of this document (standards) contains detailed requirements for accrediting environmental labo...

  14. Standardization of Laboratory Methods for the PERCH Study

    PubMed Central

    Karron, Ruth A.; Morpeth, Susan C.; Bhat, Niranjan; Levine, Orin S.; Baggett, Henry C.; Brooks, W. Abdullah; Feikin, Daniel R.; Hammitt, Laura L.; Howie, Stephen R. C.; Knoll, Maria Deloria; Kotloff, Karen L.; Madhi, Shabir A.; Scott, J. Anthony G.; Thea, Donald M.; Adrian, Peter V.; Ahmed, Dilruba; Alam, Muntasir; Anderson, Trevor P.; Antonio, Martin; Baillie, Vicky L.; Dione, Michel; Endtz, Hubert P.; Gitahi, Caroline; Karani, Angela; Kwenda, Geoffrey; Maiga, Abdoul Aziz; McClellan, Jessica; Mitchell, Joanne L.; Morailane, Palesa; Mugo, Daisy; Mwaba, John; Mwansa, James; Mwarumba, Salim; Nyongesa, Sammy; Panchalingam, Sandra; Rahman, Mustafizur; Sawatwong, Pongpun; Tamboura, Boubou; Toure, Aliou; Whistler, Toni; O’Brien, Katherine L.; Murdoch, David R.

    2017-01-01

    Abstract The Pneumonia Etiology Research for Child Health study was conducted across 7 diverse research sites and relied on standardized clinical and laboratory methods for the accurate and meaningful interpretation of pneumonia etiology data. Blood, respiratory specimens, and urine were collected from children aged 1–59 months hospitalized with severe or very severe pneumonia and community controls of the same age without severe pneumonia and were tested with an extensive array of laboratory diagnostic tests. A standardized testing algorithm and standard operating procedures were applied across all study sites. Site laboratories received uniform training, equipment, and reagents for core testing methods. Standardization was further assured by routine teleconferences, in-person meetings, site monitoring visits, and internal and external quality assurance testing. Targeted confirmatory testing and testing by specialized assays were done at a central reference laboratory. PMID:28575358

  15. National Center for Standards and Certification Information: Service and programs

    NASA Technical Reports Server (NTRS)

    Overman, Joanne

    1994-01-01

    The National Center for Standards and Certification Information (NCSCI) provides information on U.S., foreign and international voluntary standards, government regulations, and conformity assessment procedures for non-agricultural products. The Center serves as a referral service and focal point in the United States for information on standards and standards-related information. NCSCI staff respond to inquiries, maintain a reference collection of standards and standards-related documents, and serve as the U.S. inquiry point for information to and from foreign countries.

  16. Leading Antibacterial Laboratory Research by Integrating Conventional and Innovative Approaches: The Laboratory Center of the Antibacterial Resistance Leadership Group.

    PubMed

    Manca, Claudia; Hill, Carol; Hujer, Andrea M; Patel, Robin; Evans, Scott R; Bonomo, Robert A; Kreiswirth, Barry N

    2017-03-15

    The Antibacterial Resistance Leadership Group (ARLG) Laboratory Center (LC) leads the evaluation, development, and implementation of laboratory-based research by providing scientific leadership and supporting standard/specialized laboratory services. The LC has developed a physical biorepository and a virtual biorepository. The physical biorepository contains bacterial isolates from ARLG-funded studies located in a centralized laboratory and they are available to ARLG investigators. The Web-based virtual biorepository strain catalogue includes well-characterized gram-positive and gram-negative bacterial strains published by ARLG investigators. The LC, in collaboration with the ARLG Leadership and Operations Center, developed procedures for review and approval of strain requests, guidance during the selection process, and for shipping strains from the distributing laboratories to the requesting investigators. ARLG strains and scientific and/or technical guidance have been provided to basic research laboratories and diagnostic companies for research and development, facilitating collaboration between diagnostic companies and the ARLG Master Protocol for Evaluating Multiple Infection Diagnostics (MASTERMIND) initiative for evaluation of multiple diagnostic devices from a single patient sampling event. In addition, the LC has completed several laboratory-based studies designed to help evaluate new rapid molecular diagnostics by developing, testing, and applying a MASTERMIND approach using purified bacterial strains. In collaboration with the ARLG's Statistical and Data Management Center (SDMC), the LC has developed novel analytical strategies that integrate microbiologic and genetic data for improved and accurate identification of antimicrobial resistance. These novel approaches will aid in the design of future ARLG studies and help correlate pathogenic markers with clinical outcomes. The LC's accomplishments are the result of a successful collaboration with the ARLG

  17. Minimum Standards for Licensed Day Care Centers and Night-Time Centers. Revised Edition.

    ERIC Educational Resources Information Center

    Illinois State Dept. of Children and Family Services, Springfield.

    This document gives the minimum standards required for licensing day care centers and nighttime centers in the State of Illinois. The standards were established by the Department of Children and Family Services under the Child Care Act of 1969. Included in the publication are: (1) an explanation of the legal basis and application of standards; (2)…

  18. Illinois Occupational Skill Standards: Clinical Laboratory Science/Biotechnology Cluster.

    ERIC Educational Resources Information Center

    Illinois Occupational Skill Standards and Credentialing Council, Carbondale.

    This document, which is intended to serve as a guide for workforce preparation program providers, details the Illinois Occupational Skill Standards for clinical laboratory occupations programs. The document begins with a brief overview of the Illinois perspective on occupational skill standards and credentialing, the process used to develop the…

  19. Illinois Occupational Skill Standards: Agricultural Laboratory and Field Technician Cluster.

    ERIC Educational Resources Information Center

    Illinois Occupational Skill Standards and Credentialing Council, Carbondale.

    These Illinois skill standards for the agricultural laboratory and field technician cluster are intended to serve as a guide to workforce preparation program providers as they define content for their programs and to employers as they establish the skills and standards necessary for job acquisition. They could also serve as a mechanism for…

  20. Primary Standards Laboratory report, 2nd half 1993

    SciTech Connect

    Not Available

    1994-05-01

    The Primary Standards Laboratory (PSL) operates a system-wide primary standards and calibration program for the US Department of Energy, Albuquerque Field Office (DOE/AL). The PSL mission is as follows: to develop and maintain primary standards; to calibrate electrical, physical, and radiation reference standards for customer laboratories (DOE/AL nuclear weapon contractors); to conduct the technical surveys and measurement audits of these laboratories; and to recommend and implement system-wide improvements. This report summarizes activities of the PSL for the second half of 1993 and provides information pertinent to the operation of the DOE/AL Standards and Calibration Program. Specific areas covered include development projects, improvement projects, calibration and special measurements, surveys and audits, customer service, and significant events. Appendixes include certifications and reports;; a discussion about commercial calibration laboratories; PSL memoranda (PSLM); test numbers from the National Institute of Standards and Technology (NIST), formerly the National Bureau of Standards (NBS); and DOE/PSL memoranda on the Standards and Calibration Program with emphasis on traceability of PSL calibrations.

  1. Transfer standard uncertainty can cause inconclusive inter-laboratory comparisons

    NASA Astrophysics Data System (ADS)

    Wright, John; Toman, Blaza; Mickan, Bodo; Wübbeler, Gerd; Bodnar, Olha; Elster, Clemens

    2016-12-01

    Inter-laboratory comparisons use the best available transfer standards to check the participants’ uncertainty analyses, identify underestimated uncertainty claims or unknown measurement biases, and improve the global measurement system. For some measurands, instability of the transfer standard can lead to an inconclusive comparison result. If the transfer standard uncertainty is large relative to a participating laboratory’s uncertainty, the commonly used standardized degree of equivalence  ⩽1 criterion does not always correctly assess whether a participant is working within their uncertainty claims. We show comparison results that demonstrate this issue and propose several criteria for assessing a comparison result as passing, failing, or inconclusive. We investigate the behavior of the standardized degree of equivalence and alternative comparison measures for a range of values of the transfer standard uncertainty relative to the individual laboratory uncertainty values. The proposed alternative criteria successfully discerned between passing, failing, and inconclusive comparison results for the cases we examined.

  2. Standardization of ABO antibody titer measurement at laboratories in Korea.

    PubMed

    Lim, Young Ae; Kang, Seon Joo

    2014-11-01

    Measurement of the ABO antibody (Ab) titer is important in ABO-incompatible transplantation. However, to the best of our knowledge, no standard protocol or external survey program to measure the ABO Ab titer has been established in Korea. We investigated the current status of ABO Ab titer measurements at various laboratories in Korea and the impact of the protocol provided to reduce interlaboratory variations in the methods and results of ABO Ab titers. The Korean external quality assessment of blood bank laboratories sent external survey samples with a questionnaire to 68 laboratories across Korea for the measurement of ABO Ab titers in May 2012. After 6 months, a second set of survey samples were sent with a standard protocol to 53 of the previously surveyed laboratories. The protocol recommended incubation at room temperature only and use of the indirect antihuman globulin method for the tube test as well as and the column agglutination test (CAT). Several interlaboratory variations were observed in the results, technical procedures, and methods selected for measurement. We found that 80.4% laboratories hoped to change their protocol to the provisional one. Additionally, CAT showed significantly lower variation among laboratories (P=0.006) than the tube test. Our study provides baseline data regarding the current status of ABO Ab titer measurement in Korea. The standard protocol and external survey were helpful to standardize the technical procedures and select methods for ABO Ab titer measurement.

  3. Argonne Laboratory Computing Resource Center - FY2004 Report.

    SciTech Connect

    Bair, R.

    2005-04-14

    In the spring of 2002, Argonne National Laboratory founded the Laboratory Computing Resource Center, and in April 2003 LCRC began full operations with Argonne's first teraflops computing cluster. The LCRC's driving mission is to enable and promote computational science and engineering across the Laboratory, primarily by operating computing facilities and supporting application use and development. This report describes the scientific activities, computing facilities, and usage in the first eighteen months of LCRC operation. In this short time LCRC has had broad impact on programs across the Laboratory. The LCRC computing facility, Jazz, is available to the entire Laboratory community. In addition, the LCRC staff provides training in high-performance computing and guidance on application usage, code porting, and algorithm development. All Argonne personnel and collaborators are encouraged to take advantage of this computing resource and to provide input into the vision and plans for computing and computational analysis at Argonne. Steering for LCRC comes from the Computational Science Advisory Committee, composed of computing experts from many Laboratory divisions. The CSAC Allocations Committee makes decisions on individual project allocations for Jazz.

  4. Secondary calibration laboratory for ionizing radiation laboratory accreitation program National Institute of Standards and Technology National Voluntary Laboratory Accreditation Program

    SciTech Connect

    Martin, P.R.

    1993-12-31

    This paper presents an overview of the procedures and requirements for accreditation under the Secondary Calibration Laboratory for Ionizing Radiation Program (SCLIR LAP). The requirements for a quality system, proficiency testing and the onsite assessment are discussed. The purpose of the accreditation program is to establish a network of secondary calibration laboratories that can provide calibrations traceable to the primary national standards.

  5. DOE standard: The Department of Energy Laboratory Accreditation Program administration

    SciTech Connect

    1998-12-01

    This technical standard describes the US Department of Energy Laboratory Accreditation Program (DOELAP), organizational responsibilities, and the accreditation process. DOELAP evaluates and accredits personnel dosimetry and radiobioassay programs used for worker monitoring and protection at DOE and DOE contractor sites and facilities as required in Title 10, Code of Federal Regulations, Part 835, Occupational Radiation Protection. The purpose of this technical standard is to establish procedures for administering DOELAP and acquiring accreditation.

  6. MANUAL OF STANDARDS FOR REHABILITATION CENTERS AND FACILITIES.

    ERIC Educational Resources Information Center

    CANIFF, CHARLES E.; AND OTHERS

    A 5-YEAR PROJECT TO SPECIFY STANDARDS OF REHABILITATION CENTERS AND FACILITIES RESULTED IN THREE PUBLICATIONS. THIS MANUAL INCLUDES THE CHARACTERISTICS AND GOALS OF REHABILITATION FACILITIES. THE STANDARDS FOR ORGANIZATION, SERVICES THAT SHOULD BE PROVIDED, PERSONNEL INCLUDED, RECORDS AND REPORTS, FISCAL MANAGEMENT, AND THE PHYSICAL PLANT ARE…

  7. Serological Diagnosis of Paracoccidioidomycosis: High Rate of Inter-laboratorial Variability among Medical Mycology Reference Centers

    PubMed Central

    Vidal, Monica Scarpelli Martinelli; Del Negro, Gilda Maria Barbaro; Vicentini, Adriana Pardini; Svidzinski, Teresinha Inez Estivalet; Mendes-Giannini, Maria Jose; Almeida, Ana Marisa Fusco; Martinez, Roberto; de Camargo, Zoilo Pires; Taborda, Carlos Pelleschi; Benard, Gil

    2014-01-01

    Background Serological tests have long been established as rapid, simple and inexpensive tools for the diagnosis and follow-up of PCM. However, different protocols and antigen preparations are used and the few attempts to standardize the routine serological methods have not succeeded. Methodology/Principal findings We compared the performance of six Brazilian reference centers for serological diagnosis of PCM. Each center provided 30 sera of PCM patients, with positive high, intermediate and low titers, which were defined as the “reference” titers. Each center then applied its own antigen preparation and serological routine test, either semiquantitative double immunodifusion or counterimmmunoelectrophoresis, in the 150 sera from the other five centers blindly as regard to the “reference” titers. Titers were transformed into scores: 0 (negative), 1 (healing titers), 2 (active disease, low titers) and 3 (active disease, high titers) according to each center's criteria. Major discordances were considered between scores indicating active disease and scores indicating negative or healing titers; such discordance when associated with proper clinical and other laboratorial data, may correspond to different approaches to the patient's treatment. Surprisingly, all centers exhibited a high rate of “major” discordances with a mean of 31 (20%) discordant scores. Alternatively, when the scores given by one center to their own sera were compared with the scores given to their sera by the remaining five other centers, a high rate of major discordances was also found, with a mean number of 14.8 sera in 30 presenting a discordance with at least one other center. The data also suggest that centers that used CIE and pool of isolates for antigen preparation performed better. Conclusion There are inconsistencies among the laboratories that are strong enough to result in conflicting information regarding the patients' treatment. Renewed efforts should be promoted to improve

  8. Clinical trials of boron neutron capture therapy [in humans] [at Beth Israel Deaconess Medical Center][at Brookhaven National Laboratory

    SciTech Connect

    Wallace, Christine

    2001-05-29

    Assessment of research records of Boron Neutron Capture Therapy was conducted at Brookhaven National Laboratory and Beth Israel Deaconess Medical Center using the Code of Federal Regulations, FDA Regulations and Good Clinical Practice Guidelines. Clinical data were collected from subjects' research charts, and differences in conduct of studies at both centers were examined. Records maintained at Brookhaven National Laboratory were not in compliance with regulatory standards. Beth Israel's records followed federal regulations. Deficiencies discovered at both sites are discussed in the reports.

  9. Argonne's Laboratory Computing Resource Center 2009 annual report.

    SciTech Connect

    Bair, R. B.

    2011-05-13

    Now in its seventh year of operation, the Laboratory Computing Resource Center (LCRC) continues to be an integral component of science and engineering research at Argonne, supporting a diverse portfolio of projects for the U.S. Department of Energy and other sponsors. The LCRC's ongoing mission is to enable and promote computational science and engineering across the Laboratory, primarily by operating computing facilities and supporting high-performance computing application use and development. This report describes scientific activities carried out with LCRC resources in 2009 and the broad impact on programs across the Laboratory. The LCRC computing facility, Jazz, is available to the entire Laboratory community. In addition, the LCRC staff provides training in high-performance computing and guidance on application usage, code porting, and algorithm development. All Argonne personnel and collaborators are encouraged to take advantage of this computing resource and to provide input into the vision and plans for computing and computational analysis at Argonne. The LCRC Allocations Committee makes decisions on individual project allocations for Jazz. Committee members are appointed by the Associate Laboratory Directors and span a range of computational disciplines. The 350-node LCRC cluster, Jazz, began production service in April 2003 and has been a research work horse ever since. Hosting a wealth of software tools and applications and achieving high availability year after year, researchers can count on Jazz to achieve project milestones and enable breakthroughs. Over the years, many projects have achieved results that would have been unobtainable without such a computing resource. In fiscal year 2009, there were 49 active projects representing a wide cross-section of Laboratory research and almost all research divisions.

  10. The program of the ALARA Center at Brookhaven National Laboratory

    SciTech Connect

    Khan, T.A.; Baum, J.W.

    1993-01-01

    In 1984 the Brookhaven National Laboratory was asked by the Nuclear Regulatory Commission to set up a Center to monitor dose-reduction efforts in the US and abroad and to focus the industry's attention on ALARA. The paper summarizes the main work of the ALARA Center between 1984 and 1992. The Center maintains nine data bases for the NRC and the Nuclear Power Industry. These databases are constantly updated and access to them is provided through a personal computer and a modem and by periodic publications in the form of a newsletter and NUREG reports. Also described briefly are eight other projects related to dose-reduction at nuclear power plants that the Center has carried out for the NRC. Among these are projects that analyze the cost-effectiveness of engineering modifications, look at worldwide activities at dose reduction and compare US and foreign dose experience, examine high-dose worker groups and high-dose jobs, develop optimum techniques to control contamination at nuclear plants, and look at the doses being received by men and women in all sectors of the nuclear industry.

  11. The program of the ALARA Center at Brookhaven National Laboratory

    SciTech Connect

    Khan, T.A.; Baum, J.W.

    1993-04-01

    In 1984 the Brookhaven National Laboratory was asked by the Nuclear Regulatory Commission to set up a Center to monitor dose-reduction efforts in the US and abroad and to focus the industry`s attention on ALARA. The paper summarizes the main work of the ALARA Center between 1984 and 1992. The Center maintains nine data bases for the NRC and the Nuclear Power Industry. These databases are constantly updated and access to them is provided through a personal computer and a modem and by periodic publications in the form of a newsletter and NUREG reports. Also described briefly are eight other projects related to dose-reduction at nuclear power plants that the Center has carried out for the NRC. Among these are projects that analyze the cost-effectiveness of engineering modifications, look at worldwide activities at dose reduction and compare US and foreign dose experience, examine high-dose worker groups and high-dose jobs, develop optimum techniques to control contamination at nuclear plants, and look at the doses being received by men and women in all sectors of the nuclear industry.

  12. Recent progress in the NASA-Goddard Space Flight Center atomic hydrogen standards program

    NASA Technical Reports Server (NTRS)

    Reinhardt, V. S.

    1981-01-01

    At NASA Goddard Space Flight Center and through associated contractors, a broad spectrum of work is being carried out to develop improved hydrogen maser frequency standards for field use, improved experimental hydrogen maser frequency standards, and improved frequency and time distribution and measurement systems for hydrogen maser use. Recent progress in the following areas is reported: results on the Nr masers built by the Applied Physics Laboratory of Johns Hopkins University, the development of a low cost hydrogen maser at Goddard Space Flight Center, and work on a low noise phase comparison system and digitally phase locked crystal oscillator called the distribution and measurement system.

  13. Standards, Regulation and Registration of Dental Laboratories. An Industry Update.

    PubMed

    Giovannone, Paul L

    2015-01-01

    State dental associations are showing increased interest in maintaining current standards and regulations affecting the dental laboratory industry as mandated by the Food and Drug Administration. The domestic dental laboratory industry is being significantly stressed by foreign competition, rapid technology development and unprecedented consolidation, which are changing the way that prosthetic devices and restorations are manufactured and delivered to dentists. Of paramount importance to the prescribing dentist is the accurate documentation of the source and materials being used in prostheses being delivered to patients.

  14. 40 CFR 262.103 - What is the scope of the laboratory environmental management standard?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... environmental management standard? 262.103 Section 262.103 Protection of Environment ENVIRONMENTAL PROTECTION... University Laboratories XL Project-Laboratory Environmental Management Standard § 262.103 What is the scope of the laboratory environmental management standard? The Laboratory Environmental Management Standard...

  15. Manned Space-laboratories Control Center (MSCC) operations concept

    NASA Technical Reports Server (NTRS)

    Kehr, Joachim

    1993-01-01

    The initiation of the (German-) nationally funded control center for manned spaceflight operations triggered by the invitation of President Reagan to ESA, Japan, and Canada in 1984 to join the International Space Station Freedom Program is recalled. The requirements for a Manned Space-Laboratories Control Center (MSCC) as defined at the beginning of the planning and construction process in 1987 and the resulting modifications during the various programmatic scenario changes on NASA and ESA side between 1987 and now are presented. The validity of the original requirements with respect to the current scenario, which asks for a logical evolution from the execution of the D-2 mission in January 1993 via the European Columbus Precursor flights (in particular the E-1 mission) towards Columbus Attached Laboratory (APM)-operations by the end of this century are discussed. The resulting tasks of the MSCC for the various missions, the current configuration, and the ensuing operations concept leading from a more centralized concept for D-2 towards a decentralized payload operations concept for the APM and the implications with respect to European and International interfaces are presented. The planned Columbus MSCC facility architecture and its expected modifications introduced by the ESA Ministerial Conference in Munich (Nov. 1991) and follow-on discussions are briefly addressed. The last chapter outlines the planned services to be provided by the MSCC to the decentralized User (experimenter) community. Issues like decentralized mission planning on executional level, command validation, data flow coordination, archiving services, and telescience capabilities are highlighted from a MSCC point of view.

  16. A report from the AVS Standards Committee - Comparison of ion gauge calibrations by several standards laboratories

    NASA Technical Reports Server (NTRS)

    Warshawsky, I.

    1982-01-01

    Calibrations by four U.S. laboratories of four hot-cathode ion gauges, in the range 0.07-13 mPa, showed systematic differences among laboratories that were much larger than the expected error of any one calibration. They also suggested that any of the four gauges tested, if properly packaged and shipped, was able to serve as a transfer standard with probable error of 2%. A second comparison was made of the calibrations by two U.S. laboratories of some other gauges that had also been calibrated by the National Physical Laboratory, England. Results did not permit conclusive determination of whether differences were due to the laboratories or to changes in the gauges.

  17. A report from the AVS Standards Committee - Comparison of ion gauge calibrations by several standards laboratories

    NASA Technical Reports Server (NTRS)

    Warshawsky, I.

    1982-01-01

    Calibrations by four U.S. laboratories of four hot-cathode ion gauges, in the range 0.07-13 mPa, showed systematic differences among laboratories that were much larger than the expected error of any one calibration. They also suggested that any of the four gauges tested, if properly packaged and shipped, was able to serve as a transfer standard with probable error of 2%. A second comparison was made of the calibrations by two U.S. laboratories of some other gauges that had also been calibrated by the National Physical Laboratory, England. Results did not permit conclusive determination of whether differences were due to the laboratories or to changes in the gauges.

  18. Joint Langley Research Center/Jet Propulsion Laboratory CSI experiment

    NASA Technical Reports Server (NTRS)

    Neat, Gregory W.; O'Brien, John F.; Lurie, Boris J.; Garnica, Angel; Belvin, W. K.; Sulla, Jeff; Won, John

    1992-01-01

    This paper describes a joint Control Structure Interaction (CSI) experiment in which Jet Propulsion Laboratory (JPL) damping devices were incorporated into the Langley Research Center (LaRC) Phase 0 Testbed. The goals of the effort were twofold: (1) test the effectiveness of the JPL structural damping methods in a new structure and (2) assess the feasibility of combining JPL local control methods with the LaRC multiple input multiple output global control methods. Six dampers (2 piezoelectric active members, 4 viscous dampers), placed in three different regions of the structure, produced up to 26 dB attenuation in target modes. The combined control strategy in which the JPL damping methods contributed local control action and the LaRC control scheme provided global control action, produced and overall control scheme with increased stability margins and improved performance. This paper presents an overview of the technologies contributed from the two centers, the strategies used to combine them, and results demonstrating the success of the damping and cooperative control efforts.

  19. [Development of laboratory information system--quality standards].

    PubMed

    Srenger, Vesna; Stavljenić-Rukavina, Ana; Cvorisćec, Dubravka; Brkljacić, Vera; Rogić, Dunja; Juricić, Ljiljana

    2005-01-01

    The aim of the study was to determine structural modules of laboratory information system (LIS) for the application of new biomedical and information technologies by utilizing current organizational trends. The method used included definition of structural modules according to significant LIS properties, e.g., a large number of data, automation of analyses and rapid exchange of information, and according to the process of information establishment the collection, organization, selection, synthesis and distribution. Thus, outdated distributed software at the Clinical Institute of Laboratory Diagnosis has now been replaced by modular organization. Modules have been developed for the following: data input, online operation of laboratory instruments, preparation of results, compilation of medical documentation on quality assurance based on the application of quality standards, management of finances, and for point of care testing. The method of re-engineering as well as adherence to EN and ISO quality standards were utilized in planning the development of LIS based on the application of new information technologies and in shaping business processes. The application of re-engineering in LIS development results in quality improvement, reduces the cost and time necessary for performance of procedures, and improves relations in organizational structure.

  20. A consensus-based criterion standard for trauma center need.

    PubMed

    Lerner, E Brooke; Willenbring, Brian D; Pirrallo, Ronald G; Brasel, Karen J; Cady, Charles E; Colella, M Riccardo; Cooper, Arthur; Cushman, Jeremy T; Gourlay, David M; Jurkovich, Gregory J; Newgard, Craig D; Salomone, Jeffrey P; Sasser, Scott M; Shah, Manish N; Swor, Robert A; Wang, Stewart C

    2014-04-01

    In civilian trauma care, field triage is the process applied by prehospital care providers to identify patients who are likely to have severe injuries and immediately need the resources of a trauma center. Studies of the efficacy of field triage have used various measures to define trauma center need because no "criterion standard" exists, making cross-study comparisons difficult. This study aimed to develop a consensus-based functional criterion standard definition of trauma center need. Local and national experts were recruited for participation. Blinded key informant interviews were conducted in order of availability until no new themes emerged. Themes identified during the interviews were used to develop a Modified Delphi survey, which was electronically delivered via Survey Monkey. The trauma center need criteria were refined iteratively based on participant responses. Participants completed additional surveys until there was at least 80% agreement for each criterion. Fourteen experts were recruited. Five participated in key informant interviews. A Modified Delphi survey was administered five times (four modifications based on the expert's responses). After the fifth round, there was at least 82% agreement on each criterion. The final definition included 10 time-specific indicators: major surgery, advanced airway, blood products, admission for spinal cord injury, thoracotomy, pericardiocentesis, cesarean delivery, intracranial pressure monitoring, interventional radiology, and in-hospital death. We developed a consensus-based functional criterion standard definition of needing the resources of a trauma center, which may help to standardize field triage research and quality assurance in trauma systems as well as allow for cross study comparisons.

  1. 46 CFR 159.010-3 - Independent laboratory: Standards for acceptance.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 6 2014-10-01 2014-10-01 false Independent laboratory: Standards for acceptance. 159... Laboratory: Acceptance, Recognition, and Termination § 159.010-3 Independent laboratory: Standards for acceptance. (a) To be accepted by the Coast Guard as an independent laboratory, a laboratory must— (1)...

  2. 46 CFR 159.010-3 - Independent laboratory: Standards for acceptance.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 6 2011-10-01 2011-10-01 false Independent laboratory: Standards for acceptance. 159... Laboratory: Acceptance, Recognition, and Termination § 159.010-3 Independent laboratory: Standards for acceptance. (a) To be accepted by the Coast Guard as an independent laboratory, a laboratory must— (1)...

  3. 46 CFR 159.010-3 - Independent laboratory: Standards for acceptance.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 6 2012-10-01 2012-10-01 false Independent laboratory: Standards for acceptance. 159... Laboratory: Acceptance, Recognition, and Termination § 159.010-3 Independent laboratory: Standards for acceptance. (a) To be accepted by the Coast Guard as an independent laboratory, a laboratory must— (1)...

  4. 46 CFR 159.010-3 - Independent laboratory: Standards for acceptance.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 6 2013-10-01 2013-10-01 false Independent laboratory: Standards for acceptance. 159... Laboratory: Acceptance, Recognition, and Termination § 159.010-3 Independent laboratory: Standards for acceptance. (a) To be accepted by the Coast Guard as an independent laboratory, a laboratory must— (1)...

  5. 40 CFR 262.103 - What is the scope of the laboratory environmental management standard?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 27 2012-07-01 2012-07-01 false What is the scope of the laboratory... University Laboratories XL Project-Laboratory Environmental Management Standard § 262.103 What is the scope of the laboratory environmental management standard? The Laboratory Environmental Management...

  6. 46 CFR 159.010-3 - Independent laboratory: Standards for acceptance.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 6 2010-10-01 2010-10-01 false Independent laboratory: Standards for acceptance. 159... Laboratory: Acceptance, Recognition, and Termination § 159.010-3 Independent laboratory: Standards for acceptance. (a) To be accepted by the Coast Guard as an independent laboratory, a laboratory must— (1) Be...

  7. Iodine Standard Materials: Preparation and Inter-Laboratory Comparisons

    SciTech Connect

    D D Jenson; M L Adamic; J E Olson; M G Watrous; C Vockenhuber

    2014-08-01

    The Idaho National Laboratory is preparing to enter the community of AMS practioners who analyze for 129Iodine. We expect to take delivery of a 0.5 MV compact accelerator mass spectrometry system, built by NEC, in the early summer of 2014. The primary mission for this instrument is iodine; it is designed to analyze iodine in the +3 charge state. As part of the acceptance testing for this instrument, both at NEC and on-site in our laboratory, some sort of standard or reference material is needed to verify performance. Appropriate standard materials are not readily available in the commercial marketplace. Small quantities can sometimes be acquired from other laboratories already engaged in iodine analyses. In the longer-term, meaningful quantities of standard materials are needed for routine use in analyses, and for quality control functions1. We have prepared some standard materials, starting with elemental Woodward iodine and NIST SRM 3231 [Iodine-129 Isotopic Standard (high level)] 10-6 solution. The goal was to make mixtures at the 5x10-10, 5x10-11, 5x10-12 ratio levels, along with some unmodified Woodward, in the chemical form of silver iodide. Approximately twenty grams of each of these mixtures were prepared. The elemental Woodward iodine was dissolved in chloroform, then reduced to iodide using sodium bisulfite in water. At this point the NIST spike material was added, in the form of sodium iodide. The mixed iodides were oxidized back to iodine in chloroform using hydrogen peroxide. This oxidation step was essential for isotopic equilibration of the 127 and 129 atoms. The iodine was reduced to iodide using sodium bisulfite as before. Excess sulfites and sulfates were precipitated with barium nitrate. After decanting, silver nitrate was used to precipitate the desired silver iodide. Once the silver iodide was produced, the material was kept in darkness as much as possible to minimize photo-oxidation. The various mixtures were synthesized independently of each

  8. ACMG clinical laboratory standards for next-generation sequencing.

    PubMed

    Rehm, Heidi L; Bale, Sherri J; Bayrak-Toydemir, Pinar; Berg, Jonathan S; Brown, Kerry K; Deignan, Joshua L; Friez, Michael J; Funke, Birgit H; Hegde, Madhuri R; Lyon, Elaine

    2013-09-01

    Next-generation sequencing technologies have been and continue to be deployed in clinical laboratories, enabling rapid transformations in genomic medicine. These technologies have reduced the cost of large-scale sequencing by several orders of magnitude, and continuous advances are being made. It is now feasible to analyze an individual's near-complete exome or genome to assist in the diagnosis of a wide array of clinical scenarios. Next-generation sequencing technologies are also facilitating further advances in therapeutic decision making and disease prediction for at-risk patients. However, with rapid advances come additional challenges involving the clinical validation and use of these constantly evolving technologies and platforms in clinical laboratories. To assist clinical laboratories with the validation of next-generation sequencing methods and platforms, the ongoing monitoring of next-generation sequencing testing to ensure quality results, and the interpretation and reporting of variants found using these technologies, the American College of Medical Genetics and Genomics has developed the following professional standards and guidelines.

  9. ACMG clinical laboratory standards for next-generation sequencing

    PubMed Central

    Rehm, Heidi L.; Bale, Sherri J; Bayrak-Toydemir, Pinar; Berg, Jonathan S; Brown, Kerry K; Deignan, Joshua L; Friez, Michael J; Funke, Birgit H; Hegde, Madhuri R; Lyon, Elaine

    2014-01-01

    Next-generation sequencing technologies have been and continue to be deployed in clinical laboratories, enabling rapid transformations in genomic medicine. These technologies have reduced the cost of large-scale sequencing by several orders of magnitude, and continuous advances are being made. It is now feasible to analyze an individual's near-complete exome or genome to assist in the diagnosis of a wide array of clinical scenarios. Next-generation sequencing technologies are also facilitating further advances in therapeutic decision making and disease prediction for at-risk patients. However, with rapid advances come additional challenges involving the clinical validation and use of these constantly evolving technologies and platforms in clinical laboratories. To assist clinical laboratories with the validation of next-generation sequencing methods and platforms, the ongoing monitoring of next-generation sequencing testing to ensure quality results, and the interpretation and reporting of variants found using these technologies, the American College of Medical Genetics and Genomics has developed the following professional standards and guidelines. PMID:23887774

  10. Environmental Sciences Division Toxicology Laboratory standard operating procedures

    SciTech Connect

    Kszos, L.A.; Stewart, A.J.; Wicker, L.F.; Logsdon, G.M.

    1989-09-01

    This document was developed to provide the personnel working in the Environmental Sciences Division's Toxicology Laboratory with documented methods for conducting toxicity tests. The document consists of two parts. The first part includes the standard operating procedures (SOPs) that are used by the laboratory in conducting toxicity tests. The second part includes reference procedures from the US Environmental Protection Agency document entitled Short-Term Methods for Estimating the Chronic Toxicity of Effluents and Receiving Waters to Freshwater Organisms, upon which the Toxicology Laboratory's SOPs are based. Five of the SOPs include procedures for preparing Ceriodaphnia survival and reproduction test. These SOPs include procedures for preparing Ceriodaphnia food (SOP-3), maintaining Ceriodaphnia cultures (SOP-4), conducting the toxicity test (SOP-13), analyzing the test data (SOP-13), and conducting a Ceriodaphnia reference test (SOP-15). Five additional SOPs relate specifically to the fathead minnow (Pimephales promelas) larval survival and growth test: methods for preparing fathead minnow larvae food (SOP-5), maintaining fathead minnow cultures (SOP-6), conducting the toxicity test (SOP-9), analyzing the test data (SOP-12), and conducting a fathead minnow reference test (DOP-14). The six remaining SOPs describe methods that are used with either or both tests: preparation of control/dilution water (SOP-1), washing of glassware (SOP-2), collection and handling of samples (SOP-7), preparation of samples (SOP-8), performance of chemical analyses (SOP-11), and data logging and care of technical notebooks (SOP-16).

  11. Marshall Space Flight Center Materials and Processes Laboratory

    NASA Technical Reports Server (NTRS)

    Tramel, Terri L.

    2012-01-01

    Marshall?s Materials and Processes Laboratory has been a core capability for NASA for over fifty years. MSFC has a proven heritage and recognized expertise in materials and manufacturing that are essential to enable and sustain space exploration. Marshall provides a "systems-wise" capability for applied research, flight hardware development, and sustaining engineering. Our history of leadership and achievements in materials, manufacturing, and flight experiments includes Apollo, Skylab, Mir, Spacelab, Shuttle (Space Shuttle Main Engine, External Tank, Reusable Solid Rocket Motor, and Solid Rocket Booster), Hubble, Chandra, and the International Space Station. MSFC?s National Center for Advanced Manufacturing, NCAM, facilitates major M&P advanced manufacturing partnership activities with academia, industry and other local, state and federal government agencies. The Materials and Processes Laborato ry has principal competencies in metals, composites, ceramics, additive manufacturing, materials and process modeling and simulation, space environmental effects, non-destructive evaluation, and fracture and failure analysis provide products ranging from materials research in space to fully integrated solutions for large complex systems challenges. Marshall?s materials research, development and manufacturing capabilities assure that NASA and National missions have access to cutting-edge, cost-effective engineering design and production options that are frugal in using design margins and are verified as safe and reliable. These are all critical factors in both future mission success and affordability.

  12. NASA Glenn Research Center Acoustical Testing Laboratory: Five year retrospective

    NASA Astrophysics Data System (ADS)

    Cooper, Beth A.; Akers, James C.; Passe, Paul J.

    2005-09-01

    In the five years since the NASA Glenn Research Center Acoustical Testing Laboratory (ATL) opened its doors in September, 2000, it has developed a comprehensive array of services and products that support hearing conservation goals within NASA and industry. The ATL provides acoustic emission testing and noise control engineering services for a variety of specialized customers, particularly developers of equipment and science experiments manifested for NASA's manned space missions. The ATL aggressively supports the vision of a low-noise on-orbit environment, which facilitates mission success as well as crew health, safety, and comfort. In concert with these goals, the ATL also produces and distributes free educational resources and low-noise advocacy tools for hearing conservation education and awareness. Among these are two compact discs of auditory demonstrations (of phenomena in acoustics, hearing conservation, and communication), and presentations, software packages, and other educational materials for use by engineers, audiologists, and other hearing conservation stakeholders. This presentation will highlight ATL's construction, history, technical capabilities, and current projects and will feature demonstrations of some of the unique educational resource materials that are distributed by the ATL.

  13. Radiometric validation of NASA's Ames Research Center's Sensor Calibration Laboratory.

    PubMed

    Brown, Steven W; Johnson, B Carol; Biggar, Stuart F; Zalewski, Edward F; Cooper, John; Hajek, Pavel; Hildum, Edward; Grant, Patrick; Barnes, Robert A; Butler, James J

    2005-10-20

    The National Aeronautics and Space Administration's (NASA's) Ames Research Center's Airborne Sensor Facility (ASF) is responsible for the calibration of several airborne Earth-viewing sensor systems in support of NASA Earth Observing System (EOS) investigations. The primary artifact used to calibrate these sensors in the reflective solar region from 400 to 2500 nm is a lamp-illuminated integrating sphere source. In September 1999, a measurement comparison was made at the Ames ASF Sensor Calibration Facility to validate the radiometric scale, establish the uncertainties assigned to the radiance of this source, and examine its day-to-day repeatability. The comparison was one of a series of validation activities overseen by the EOS Calibration Program to ensure the radiometric calibration accuracy of sensors used in long-term, global, remote-sensing studies. Results of the comparison, including an evaluation of the Ames Sensor Calibration Laboratory (SCL) measurement procedures and assigned radiometric uncertainties, provide a validation of their radiometric scale at the time of the comparison. Additionally, the maintenance of the radiance scale was evaluated by use of independent, long-term, multiyear radiance validation measurements of the Ames sphere source. This series of measurements provided an independent assessment of the radiance values assigned to integrating sphere sources by the Ames SCF. Together, the measurements validate the SCF radiometric scale and assigned uncertainties over the time period from September 1999 through July 2003.

  14. Radiometric validation of NASA's Ames Research Center's Sensor Calibration Laboratory

    SciTech Connect

    Brown, Steven W.; Johnson, B. Carol; Biggar, Stuart F.; Zalewski, Edward F.; Cooper, John; Hajek, Pavel; Hildum, Edward; Grant, Patrick; Barnes, Robert A.; Butler, James J

    2005-10-20

    The National Aeronautics and Space Administration's (NASA's) Ames Research Center's Airborne Sensor Facility (ASF) is responsible for the calibration of several airborne Earth-viewing sensor systems in support of NASA Earth Observing System (EOS) investigations. The primary artifact used to calibrate these sensors in the reflective solar region from 400 to 2500 nm is a lamp-illuminated integrating sphere source. In September 1999, a measurement comparison was made at the Ames ASF Sensor Calibration Facility to validate the radiometric scale, establish the uncertainties assigned to the radiance of this source, and examine its day-to-day repeatability. The comparison was one of a series of validation activities overseen by the EOS Calibration Program to ensure the radiometric calibration accuracy of sensors used in long-term, global, remote-sensing studies. Results of the comparison, including an evaluation of the Ames Sensor Calibration Laboratory (SCL) measurement procedures and assigned radiometric uncertainties, provide a validation of their radiometric scale at the time of the comparison. Additionally, the maintenance of the radiance scale was evaluated by use of independent, long-term, multiyear radiance validation measurements of the Ames sphere source. This series of measurements provided an independent assessment of the radiance values assigned to integrating sphere sources by the Ames SCF. Together, the measurements validate the SCF radiometric scale and assigned uncertainties over the time period from September 1999 through July 2003.

  15. Services of the CDRH X-ray calibration laboratory and their traceability to National Standards

    SciTech Connect

    Cerra, F.; Heaton, H.T.

    1993-12-31

    The X-ray Calibration Laboratory (XCL) of the Center for Devices and Radiological Health (CDRH) provides calibration services for the Food and Drug Administration (FDA). The instruments calibrated are used by FDA and contract state inspectors to verify compliance with federal x-ray performance standards and for national surveys of x-ray trends. In order to provide traceability of measurements, the CDRH XCL is accredited by the National Voluntary Laboratory Accreditation Program (NVLAP) for reference, diagnostic, and x-ray survey instrument calibrations. In addition to these accredited services, the CDRH XCL also calibrates non-invasive kVp meters in single- and three-phase x-ray beams, and thermoluminescent dosimeter (TLD) chips used to measure CT beam profiles. The poster illustrates these services and shows the traceability links back to the National Standards.

  16. Laboratory diagnosis of Ebola virus disease and corresponding biosafety considerations in the China Ebola Treatment Center.

    PubMed

    Huang, Qing; Fu, Wei-Ling; You, Jian-Ping; Mao, Qing

    2016-10-01

    Ebola virus disease (EVD), caused by Ebola virus (EBOV), is a potent acute infectious disease with a high case-fatality rate. Etiological and serological EBOV detection methods, including techniques that involve the detection of the viral genome, virus-specific antigens and anti-virus antibodies, are standard laboratory diagnostic tests that facilitate confirmation or exclusion of EBOV infection. In addition, routine blood tests, liver and kidney function tests, electrolytes and coagulation tests and other diagnostic examinations are important for the clinical diagnosis and treatment of EVD. Because of the viral load in body fluids and secretions from EVD patients, all body fluids are highly contagious. As a result, biosafety control measures during the collection, transport and testing of clinical specimens obtained from individuals scheduled to undergo EBOV infection testing (including suspected, probable and confirmed cases) are crucial. This report has been generated following extensive work experience in the China Ebola Treatment Center (ETC) in Liberia and incorporates important information pertaining to relevant diagnostic standards, clinical significance, operational procedures, safety controls and other issues related to laboratory testing of EVD. Relevant opinions and suggestions are presented in this report to provide contextual awareness associated with the development of standards and/or guidelines related to EVD laboratory testing.

  17. Behavioral Health and Performance Laboratory Standard Measures (BHP-SM)

    NASA Technical Reports Server (NTRS)

    Williams, Thomas J.; Cromwell, Ronita

    2017-01-01

    The Spaceflight Standard Measures is a NASA Johnson Space Center Human Research Project (HRP) project that proposes to collect a set of core measurements, representative of many of the human spaceflight risks, from astronauts before, during and after long-duration International Space Station (ISS) missions. The term "standard measures" is defined as a set of core measurements, including physiological, biochemical, psychosocial, cognitive, and functional, that are reliable, valid, and accepted in terrestrial science, are associated with a specific and measurable outcome known to occur as a consequence of spaceflight, that will be collected in a standardized fashion from all (or most) crewmembers. While such measures might be used to define standards of health and performance or readiness for flight, the prime intent in their collection is to allow longitudinal analysis of multiple parameters in order to answer a variety of operational, occupational, and research-based questions. These questions are generally at a high level, and the approach for this project is to populate the standard measures database with the smallest set of data necessary to indicate further detailed research is required. Also included as standard measures are parameters that are not outcome-based in and of-themselves, but provide ancillary information that supports interpretation of the outcome measures, e.g., nutritional assessment, vehicle environmental parameters, crew debriefs, etc. The project's main aim is to ensure that an optimized minimal set of measures is consistently captured from all ISS crewmembers until the end of Station in order to characterize the human in space. -This allows the HRP to identify, establish, and evaluate a common set of measures for use in spaceflight and analog research to: develop baselines, systematically characterize risk likelihood and consequences, and assess effectiveness of countermeasures that work for behavioral health and performance risk factors

  18. A Discussion of the Draft Proposal for Data Exchange Standards for Clinical Laboratory Results

    PubMed Central

    McDonald, Clement; Wiederhold, Gio; Simborg, Donald W.; Hammond, Ed; Jelovsek, Fredrick R.; Schneider, Ken

    1984-01-01

    A task force of AAMSI is developing standards for data exchange between laboratory and clinical practice. An early draft standard is presented. We look for criticism and comments from commercial laboratories, hospitals, system developers and other interested parties.

  19. Standardization of pathology laboratories in Pakistan: problems and prospects.

    PubMed

    Ahmad, Manzoor; Khan, Farooq Ahmad; Ahmad, Sadia Atif

    2009-03-01

    A Total Quality Management System with an internationally recognized accreditation process is the only guarantee of a reliable pathology service. However in a developing country like Pakistan nearly 90% of labs are small and without adequate physical and man power infrastructures. A modified plan may have to be tailored for them. A two tier system has been formulated. Accreditation based on ISO 15189 is to be introduced on voluntary basis. The labs which do not qualify for international standardization would be brought into quality net through a registration process. All such labs will be initiated into a simplified quality management system. Participation in proficiency testing program will be mandatory. They will be provided education and training to become eligible for accreditation. It is hoped that this simplified system will provide an impetus for evolving a workable and comprehensive mechanism through which pathology laboratories in the country will be able to offer better and more reliable services.

  20. Hydrogen Field Test Standard: Laboratory and Field Performance

    PubMed Central

    Pope, Jodie G.; Wright, John D.

    2015-01-01

    The National Institute of Standards and Technology (NIST) developed a prototype field test standard (FTS) that incorporates three test methods that could be used by state weights and measures inspectors to periodically verify the accuracy of retail hydrogen dispensers, much as gasoline dispensers are tested today. The three field test methods are: 1) gravimetric, 2) Pressure, Volume, Temperature (PVT), and 3) master meter. The FTS was tested in NIST's Transient Flow Facility with helium gas and in the field at a hydrogen dispenser location. All three methods agree within 0.57 % and 1.53 % for all test drafts of helium gas in the laboratory setting and of hydrogen gas in the field, respectively. The time required to perform six test drafts is similar for all three methods, ranging from 6 h for the gravimetric and master meter methods to 8 h for the PVT method. The laboratory tests show that 1) it is critical to wait for thermal equilibrium to achieve density measurements in the FTS that meet the desired uncertainty requirements for the PVT and master meter methods; in general, we found a wait time of 20 minutes introduces errors < 0.1 % and < 0.04 % in the PVT and master meter methods, respectively and 2) buoyancy corrections are important for the lowest uncertainty gravimetric measurements. The field tests show that sensor drift can become a largest component of uncertainty that is not present in the laboratory setting. The scale was calibrated after it was set up at the field location. Checks of the calibration throughout testing showed drift of 0.031 %. Calibration of the master meter and the pressure sensors prior to travel to the field location and upon return showed significant drifts in their calibrations; 0.14 % and up to 1.7 %, respectively. This highlights the need for better sensor selection and/or more robust sensor testing prior to putting into field service. All three test methods are capable of being successfully performed in the field and give

  1. Inquiry-based laboratory investigations and student performance on standardized tests in biological science

    NASA Astrophysics Data System (ADS)

    Patke, Usha

    Achievement data from the 3rd International Mathematics and Sciences Study and Program for International Student Assessment in science have indicated that Black students from economically disadvantaged families underachieve at alarming rates in comparison to White and economically advantaged peer groups. The study site was a predominately Black, urban school district experiencing underachievement. The purpose of this correlational study was to examine the relationship between students' use of inquiry-based laboratory investigations and their performance on the Biology End of Course Test, as well as to examine the relationship while partialling out the effects of student gender. Constructivist theory formed the theoretical foundation of the study. Students' perceived levels of experience with inquiry-based laboratory investigations were measured using the Laboratory Program Variable Inventory (LPVI) survey. LPVI scores of 256 students were correlated with test scores and were examined by student gender. The Pearson correlation coefficient revealed a small direct correlation between students' experience in inquiry-based laboratory investigation classes and standardized test scores on the Biology EOCT. A partial correlational analysis indicated that the correlation remained after controlling for gender. This study may prompt a change from teacher-centered to student-centered pedagogy at the local site in order to increase academic achievement for all students. The results of this study may also influence administrators and policy makers to initiate local, state, or nationwide curricular development. A change in curriculum may promote social change as students become more competent, and more able, to succeed in life beyond secondary school.

  2. Integrating standard operating procedures and industry notebook standards to evaluate students in laboratory courses.

    PubMed

    Wallert, Mark A; Provost, Joseph J

    2014-01-01

    To enhance the preparedness of graduates from the Biochemistry and Biotechnology (BCBT) Major at Minnesota State University Moorhead for employment in the bioscience industry we have developed a new Industry certificate program. The BCBT Industry Certificate was developed to address specific skill sets that local, regional, and national industry experts identified as lacking in new B.S. and B.A. biochemistry graduates. The industry certificate addresses concerns related to working in a regulated industry such as Good Laboratory Practices, Good Manufacturing Practices, and working in a Quality System. In this article we specifically describe how we developed a validation course that uses Standard Operating Procedures to describe grading policy and laboratory notebook requirements in an effort to better prepare students to transition into industry careers.

  3. Standards for thyroid laboratory testing, and cognitive functions after menopause

    PubMed Central

    Bejga, Przemysław; Witczak, Mariusz; Łyszcz, Robert; Makara-Studzinska, Marta

    2014-01-01

    Introduction The aim of the study is to analyze the relationship between normative and non-normative thyroid tests (TSH, TT4, TT3, FT3, FT4, anti-TPO, anti-Tg, AB-TSHR) and the level of cognitive functions in postmenopausal women. Material and methods The study group consisted of 383 women from south-eastern Poland, aged 50-65 years. The cognitive functions were evaluated using a diagnostic instrument – Central Nervous System – Vital Signs (CNS-VS). Blood was collected for determination of the following parameters: TSH, TT4, TT3, FT3, FT4, anti-TPO, anti-Tg, AB-TSHR. Results There were significant differences in NCI, executive functions, psychomotor speed, reaction time, complex attention and cognitive flexibility, depending on the normative and non-normative level of TSH. Women whose level of FT3 was at the lower limit of the normal range obtained poorer results in psychomotor speed, while subjects with levels of FT4 below the standard achieved significantly lower scores for this function. The relationship between NCI and cognitive functions, and the normative and non-normative anti-TPO results, showed significant differences in verbal memory, visual memory, processing speed and reaction time. The level of AB-TSHR reported as normal or above the norm significantly differentiated from the results of NCI, processing speed, executive functions, psychomotor speed, complex attention and cognitive flexibility. Conclusions Concentrations of laboratory parameters assessing the thyroid function located within the upper limits of the normal range showed a different relationship with the cognitive performance than concentrations located within the lower limits of the standard. PMID:26327860

  4. 42 CFR 493.1407 - Standard; Laboratory director responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... testing; (2) Ensure that the physical plant and environmental conditions of the laboratory are appropriate... appropriate staff to evaluate the laboratory's performance and to identify any problems that require...

  5. Workshop on laboratory protocol standards for the Molecular Methods Database.

    PubMed

    Klingström, Tomas; Soldatova, Larissa; Stevens, Robert; Roos, T Erik; Swertz, Morris A; Müller, Kristian M; Kalaš, Matúš; Lambrix, Patrick; Taussig, Michael J; Litton, Jan-Eric; Landegren, Ulf; Bongcam-Rudloff, Erik

    2013-01-25

    Management of data to produce scientific knowledge is a key challenge for biological research in the 21st century. Emerging high-throughput technologies allow life science researchers to produce big data at speeds and in amounts that were unthinkable just a few years ago. This places high demands on all aspects of the workflow: from data capture (including the experimental constraints of the experiment), analysis and preservation, to peer-reviewed publication of results. Failure to recognise the issues at each level can lead to serious conflicts and mistakes; research may then be compromised as a result of the publication of non-coherent protocols, or the misinterpretation of published data. In this report, we present the results from a workshop that was organised to create an ontological data-modelling framework for Laboratory Protocol Standards for the Molecular Methods Database (MolMeth). The workshop provided a set of short- and long-term goals for the MolMeth database, the most important being the decision to use the established EXACT description of biomedical ontologies as a starting point.

  6. Standardized Laboratory Feeding of Larval Aedes japonicus japonicus (Diptera: Culicidae).

    PubMed

    Bock, Friederike; Kuch, Ulrich; Pfenninger, Markus; Müller, Ruth

    2015-01-01

    The Asian bush mosquito (Aedes japonicus japonicus, Theobald 1901) is an invasive culicid species which originates in Asia but is nowadays present in northern America and Europe. It is a competent vector for several human disease pathogens. In addition to the public health threat, this invasive species may also be an ecological threat for native container-breeding mosquitoes which share a similar larval habitat. Therefore, it is of importance to gain knowledge on ecological and eco-toxicological features of the Asian bush mosquito. However, optimal laboratory feeding conditions have not yet been established. Standardized feeding methods will be needed in assessing the impact of insecticides or competitional strength of this species. To fill this gap, we performed experiments on food quality and quantity for Ae. j. japonicus larvae. We found out that the commercial fish food TetraMin (Tetra, Melle, Germany) in a dose of 10 mg per larva is the most suitable food tested. We also suggest a protocol with a feeding sequence of seven portions for all larval stages of this species.

  7. Michigan/Air Force Research Laboratory (AFRL) Collaborative Center in Control Science (MACCCS)

    DTIC Science & Technology

    2016-09-01

    AFRL-RQ-WP-TR-2016-0139 MICHIGAN/AIR FORCE RESEARCH LABORATORY (AFRL) COLLABORATIVE CENTER IN CONTROL SCIENCE (MACCCS) Anouck Girard...inside pages AIR FORCE RESEARCH LABORATORY AEROSPACE SYSTEMS DIRECTORATE WRIGHT-PATTERSON AIR FORCE BASE, OH 45433-7541 AIR FORCE...Final 18 April 2007 – 30 September 2016 4. TITLE AND SUBTITLE MICHIGAN/AIR FORCE RESEARCH LABORATORY (AFRL) COLLABORATIVE CENTER IN CONTROL SCIENCE

  8. 42 CFR 493.1407 - Standard; Laboratory director responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... assessment programs are established and maintained to assure the quality of laboratory services provided and... developed and used for each of the tests performed in the laboratory provide quality laboratory services for... capability of providing the quality of results required for patient care; (ii) Verification procedures...

  9. The NASA Lewis Research Center High Temperature Fatigue and Structures Laboratory

    NASA Technical Reports Server (NTRS)

    Mcgaw, M. A.; Bartolotta, P. A.

    1987-01-01

    The physical organization of the NASA Lewis Research Center High Temperature Fatigue and Structures Laboratory is described. Particular attention is given to uniaxial test systems, high cycle/low cycle testing systems, axial torsional test systems, computer system capabilities, and a laboratory addition. The proposed addition will double the floor area of the present laboratory and will be equipped with its own control room.

  10. Langley Research Center Standard for the Evaluation of Socket Welds

    NASA Technical Reports Server (NTRS)

    Berry, R. F., Jr.

    1985-01-01

    A specification utilized for the nondestructive evaluation of socket type pipe joints at Langley Research Center (LaRC) is discussed. The scope of hardware shall include, but is not limited to, all common pipe fittings: tees, elbows, couplings, caps, and so forth, socket type flanges, unions, and valves. In addition, the exterior weld of slip on flanges shall be inspected using this specification. At the discretion of the design engineer, standard practice engineer, Fracture Mechanics Engineering Section, Pressure Systems Committee, or other authority, four nondestructive evaluation techniques may be utilized exclusively, or in combination, to inspect socket type welds. These techniques are visual, radiographic, magnetic particle, and dye penetrant. Under special circumstances, other techniques (such as eddy current or ultrasonics) may be required and their application shall be guided by the appropriate sections of the American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel Code (B&PVC).

  11. 77 FR 14805 - Clinical Laboratory Improvement Advisory Committee, Centers for Disease Control and Prevention...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-13

    ... HUMAN SERVICES Centers for Disease Control and Prevention Clinical Laboratory Improvement Advisory Committee, Centers for Disease Control and Prevention: Notice of Charter Renewal This gives notice under the... Improvement Advisory Committee, Centers for Disease Control and Prevention (CDC), Department of Health and...

  12. Space Radar Laboratory photos taken at Kennedy Space Center

    NASA Image and Video Library

    1994-03-18

    S94-30392 (16 Feb 1994) --- The Space Radar Laboratory-1 (SRL-1) is being transferred from the payload canister transporter into the payload bay of the Space Shuttle Endeavour. SRL-1 will be launched on STS-59 in April of this year.

  13. Laboratory and blood bank needs of a perinatal center.

    PubMed

    Mannino, F L

    1976-09-01

    Prenatal and neonatal laboratory diagnostic tests are discussed in terms of purpose, technique, and evaluation of results. The need for quick access to fresh blood products must be appreciated by the blood bank, and the perinatologist must have a thorough understanding of blood products and the need for established procedures to guarantee safe transfusion.

  14. Improving Consistency in Large Laboratory Courses: A Design for a Standardized Practical Exam

    ERIC Educational Resources Information Center

    Chen, Xinnian; Graesser, Donnasue; Sah, Megha

    2015-01-01

    Laboratory courses serve as important gateways to science, technology, engineering, and mathematics education. One of the challenges in assessing laboratory learning is to conduct meaningful and standardized practical exams, especially for large multisection laboratory courses. Laboratory practical exams in life sciences courses are frequently…

  15. Improving Consistency in Large Laboratory Courses: A Design for a Standardized Practical Exam

    ERIC Educational Resources Information Center

    Chen, Xinnian; Graesser, Donnasue; Sah, Megha

    2015-01-01

    Laboratory courses serve as important gateways to science, technology, engineering, and mathematics education. One of the challenges in assessing laboratory learning is to conduct meaningful and standardized practical exams, especially for large multisection laboratory courses. Laboratory practical exams in life sciences courses are frequently…

  16. 42 CFR 493.1405 - Standard; Laboratory director qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... degree in a chemical, physical, biological, or clinical laboratory science from an accredited institution...) Have earned a master's degree in a chemical, physical, biological or clinical laboratory science or..., physical, or biological science or medical technology from an accredited institution; (ii) Have at least 2...

  17. 42 CFR 493.1405 - Standard; Laboratory director qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... degree in a chemical, physical, biological, or clinical laboratory science from an accredited institution...) Have earned a master's degree in a chemical, physical, biological or clinical laboratory science or..., physical, or biological science or medical technology from an accredited institution; (ii) Have at least 2...

  18. 42 CFR 493.1405 - Standard; Laboratory director qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... degree in a chemical, physical, biological, or clinical laboratory science from an accredited institution...) Have earned a master's degree in a chemical, physical, biological or clinical laboratory science or..., physical, or biological science or medical technology from an accredited institution; (ii) Have at least 2...

  19. 42 CFR 493.1405 - Standard; Laboratory director qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... degree in a chemical, physical, biological, or clinical laboratory science from an accredited institution...) Have earned a master's degree in a chemical, physical, biological or clinical laboratory science or..., physical, or biological science or medical technology from an accredited institution; (ii) Have at least 2...

  20. 42 CFR 493.1445 - Standard; Laboratory director responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... assessment programs are established and maintained to assure the quality of laboratory services provided and... quality laboratory services for all aspects of test performance, which includes the preanalytic, analytic... methodologies selected have the capability of providing the quality of results required for patient care;...

  1. Laboratory Information Analysis within the Russian Center for Technological Diagnostics

    DTIC Science & Technology

    2004-03-15

    software requirements of the 12th Main Directorate since it is open source code for tempest-level certification and uses International Organization for...instruments in the MOD fixed and mobile laboratory system. The software utilizes open- source procedures as a technique to minimize the service and...instructions, searching existing data sources , gathering and maintaining the data needed, and completing and reviewing the collection of information. Send

  2. Disease surveillance system evaluation as a model for improved integration and standardization of the laboratory component in the Field Epidemiology and Laboratory Training Program (FELTP) curriculum worldwide.

    PubMed

    Rush, Thomas

    2012-11-01

    Integration of laboratory training into the Centers for Disease Control and Prevention's (CDC) Field Epidemiology Training Program (FETP) began in 2004 and has advanced the training of laboratory scientists worldwide on the basic principles of epidemiology, disease surveillance, and outbreak investigation. The laboratory component of the FE(L)TP training has traditionally been disease specific, revolving around classroom and bench training on laboratory methods, and field placement in areas where services are needed. There is however a need to improve the integration of epidemiology elements used in surveillance, outbreak investigation, and evaluation activities with specific measurable laboratory activities that could in turn impact the overall disease surveillance and response. A systematic and clear evaluation guideline for the laboratory components of disease surveillance systems alongside the corresponding epidemiological indicators can better identify, address, and mitigate weaknesses that may exist in the entire surveillance system, and also help to integrate and standardize the FE(L)TP curriculum content. The institution of laboratory Quality Management System principles linked to a comprehensive surveillance evaluation scheme will result in improved disease surveillance, response, and overall laboratory capacity over time.

  3. Semen analysis standardization: is there any problem in Polish laboratories?

    PubMed Central

    Walczak-Jedrzejowska, Renata; Marchlewska, Katarzyna; Oszukowska, Elzbieta; Filipiak, Eliza; Bergier, Leszek; Slowikowska-Hilczer, Jolanta

    2013-01-01

    The aim of the study was to determine the degree of compliance of Polish laboratories with World Health Organization (WHO) recommendations, with regard to semen analysis methodology. A survey requesting information about methods of semen analysis was distributed to employees of 55 laboratories. Respondents who had participated in external seminological workshops (31%) were termed certified respondents (CR), the remaining (69%)—non-certified respondents (NCR). Only one laboratory (6%) in the CR group and none in the NCR were compliant with WHO guidelines for methods and equipment used to evaluate seminal volume, sperm motility, concentration, vitality and morphology. Most problems were of volume measurement (weighing method was reported by 17% of CR and 10% of NCR) and staining method for sperm morphology (Papanicolau or Diff–Quik were found in 33% of CR and 23% of NCR). A three- or four-point grading of sperm motility was used by the majority of respondents; however, 17% of CR and 37% of NCR did not use a laboratory counter to tally spermatozoa. Although a haemocytometer method was used by 80% of laboratories in each group, the improved Neubauer chamber was used only by 42% of CR and 19% of NCR. In each group, 24% of laboratories did not perform a vitality test. Procedural errors and the interchangeable utilization of two or even three methods to analyse a given parameter was observed in both groups. The results indicate a need for standardisation of the methods and continuous, unified training in semen analysis in Polish laboratories. PMID:23817502

  4. Semen analysis standardization: is there any problem in Polish laboratories?

    PubMed

    Walczak-Jedrzejowska, Renata; Marchlewska, Katarzyna; Oszukowska, Elzbieta; Filipiak, Eliza; Bergier, Leszek; Slowikowska-Hilczer, Jolanta

    2013-09-01

    The aim of the study was to determine the degree of compliance of Polish laboratories with World Health Organization (WHO) recommendations, with regard to semen analysis methodology. A survey requesting information about methods of semen analysis was distributed to employees of 55 laboratories. Respondents who had participated in external seminological workshops (31%) were termed certified respondents (CR), the remaining (69%)-non-certified respondents (NCR). Only one laboratory (6%) in the CR group and none in the NCR were compliant with WHO guidelines for methods and equipment used to evaluate seminal volume, sperm motility, concentration, vitality and morphology. Most problems were of volume measurement (weighing method was reported by 17% of CR and 10% of NCR) and staining method for sperm morphology (Papanicolau or Diff-Quik were found in 33% of CR and 23% of NCR). A three- or four-point grading of sperm motility was used by the majority of respondents; however, 17% of CR and 37% of NCR did not use a laboratory counter to tally spermatozoa. Although a haemocytometer method was used by 80% of laboratories in each group, the improved Neubauer chamber was used only by 42% of CR and 19% of NCR. In each group, 24% of laboratories did not perform a vitality test. Procedural errors and the interchangeable utilization of two or even three methods to analyse a given parameter was observed in both groups. The results indicate a need for standardisation of the methods and continuous, unified training in semen analysis in Polish laboratories.

  5. Safety evaluation of a new proposed standard laboratory coat

    SciTech Connect

    Pane, A.J.

    1984-07-01

    A proposed disposable laboratory coat was destructively tested and compared to the present coat. Tests included flame, acids, bases, solvents, exploding glass, allergic reactions, dust penetration, and tensile properties. (ACR)

  6. 42 CFR 493.1445 - Standard; Laboratory director responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., and postanalytic phases of testing; (2) Ensure that the physical plant and environmental conditions of... appropriate staff to evaluate the laboratory's performance and to identify any problems that require...

  7. About Region 3's Laboratory and Field Services at EPA's Environmental Science Center

    EPA Pesticide Factsheets

    Mission & contact information for EPA Region 3's Laboratory and Field Services located at EPA's Environmental Science Center: the Office of Analytical Services and Quality Assurance & Field Inspection Program

  8. 77 FR 16551 - Standards for Private Laboratory Analytical Packages and Introduction to Laboratory Related...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-21

    ... Introduction to Laboratory Related Portions of the Food Modernization Safety Act for Private Laboratory... and Introduction to Laboratory Related Portions of the Food Modernization Safety Act for Private... and an introduction to sections of the Food Safety Modernization Act of January 6, 2011, that...

  9. Challenges and opportunities for medical directors in pathology and laboratory medicine: standardization, integration, and innovation.

    PubMed

    Hernandez, James S; Dale, Jane C; Bennet, Kevin E; Varkey, Prathibha

    2010-01-01

    Because the practice of pathology and laboratory medicine evolves rapidly, laboratory medical directors must constantly introduce new tests and services and continue to provide consistent, reliable results for existing tests. Innovations in laboratory medicine are frequently introduced, and the number of commercial vendors of test kits and reagents increases yearly. These innovations, however, may pose barriers to standardization and integration of laboratories and to interpretation of results generated by different laboratories. We propose a practical framework for medical directors to address the seemingly contradictory challenges of standardizing and integrating while simultaneously providing the flexibility to introduce innovations. We recommend initiating standardization first, then integration, while maintaining flexibility for innovation. As organizations strive to create effective processes to enhance value, the role of the laboratory medical director will become critical in resolving the natural tension between standardization/integration and innovation in laboratory medicine and pathology.

  10. Capability of the Gas Analysis and Testing Laboratory at the NASA Johnson Space Center

    NASA Technical Reports Server (NTRS)

    Broerman, Craig; Jimenez, Javier; Sweterlitsch, Jeff

    2012-01-01

    The Gas Analysis and Testing Laboratory is an integral part of the testing performed at the NASA Johnson Space Center. The Gas Analysis and Testing Laboratory is a high performance laboratory providing real time analytical instruments to support manned and unmanned testing. The lab utilizes precision gas chromatographs, gas analyzers and spectrophotometers to support the technology development programs within the NASA community. The Gas Analysis and Testing Laboratory works with a wide variety of customers and provides engineering support for user-specified applications in compressed gas, chemical analysis, general and research laboratory.

  11. Capability of the Gas Analysis and Testing Laboratory at the NASA Johnson Space Center

    NASA Technical Reports Server (NTRS)

    Broerman, Craig; Jimenez, Javier; Sweterlitsch, Jeff

    2011-01-01

    The Gas Analysis and Testing Laboratory is an integral part of the testing performed at the NASA Johnson Space Center. The Gas Analysis and Testing Laboratory is a high performance laboratory providing real time analytical instruments to support manned and unmanned testing. The lab utilizes precision gas chromatographs, gas analyzers and spectrophotometers to support the technology development programs within the NASA community. The Gas Analysis and Testing Laboratory works with a wide variety of customers and provides engineering support for user-specified applications in compressed gas, chemical analysis, general and research laboratory

  12. Space Radar Laboratory photos taken at Kennedy Space Center

    NASA Image and Video Library

    1994-03-18

    S94-30393 (23 Nov 1993) --- In the south level IV stand of the Operations and Checkout Building low bay, the Space Radar Laboratory -1 (SRL-1) antenna is being placed atop a pallet which holds the antenna electronics. SRL-1 is scheduled to fly on Space Shuttle mission STS-59 next year. It is comprised of two different imaging radars, the Spaceborne Imaging Radar-C (SIR-C) and the X-band Synthetic Aperture Radar (X-SAR). These radars are the most advanced of their kind to fly in space to date, and will allow scientists to make highly detailed studies of the Earth's surface on a global scale. An Interface Verification Test of the antenna and a Mission Sequence Test will be performed on the fully assembled SRL-1 later this month.

  13. Multicenter Comparison of Laboratory Performance in Cytomegalovirus and Epstein-Barr Virus Viral Load Testing using International Standards

    PubMed Central

    Rychert, Jenna; Danziger-Isakov, Lara; Yen-Lieberman, Belinda; Storch, Gregory; Buller, Richard; Sweet, Stewart C.; Mehta, Aneesh K.; Cheeseman, Jennifer A.; Heeger, Peter; Rosenberg, Eric S.; Fishman, Jay A.

    2015-01-01

    Background Infections with cytomegalovirus (CMV) and Epstein Barr Virus (EBV) remain important in solid organ transplantation. Quantitative viral nucleic acid testing is a major advance to patient management. These assays are limited by a lack of standardization, resulting in viral load measurements that differ among clinical laboratories. The variability in viral load measurements makes interpretation of multicenter clinical trials data difficult. This study compares the current practices in CMV and EBV viral load testing at four large transplant centers participating in multicenter Clinical Trials in Organ Transplantation (CTOT/CTOTC). Methods Viral load testing was performed on well-defined viral preparations according to standard operating procedures at each site. Results Among centers, CMV viral load testing was accurate compared to WHO International Standards and within acceptable variation for this testing method. EBV viral load data were more variable and less accurate despite the use of international standards. Conclusions These data suggest that comparison of CMV, but not EBV, viral load measurements at these sites is possible using current assays and control standards. Standardization of these assays is facilitated by using the WHO International Standards and will allow comparison of viral load results among transplant centers. Assay standardization must be performed prior to initiation of multicenter trials. PMID:25303316

  14. Multicenter comparison of laboratory performance in cytomegalovirus and Epstein-Barr virus viral load testing using international standards.

    PubMed

    Rychert, Jenna; Danziger-Isakov, Lara; Yen-Lieberman, Belinda; Storch, Gregory; Buller, Richard; Sweet, Stewart C; Mehta, Aneesh K; Cheeseman, Jennifer A; Heeger, Peter; Rosenberg, Eric S; Fishman, Jay A

    2014-12-01

    Infections with cytomegalovirus (CMV) and Epstein-Barr virus (EBV) remain important in solid organ transplantation. Quantitative viral nucleic acid testing is a major advance to patient management. These assays are limited by a lack of standardization, resulting in viral load measurements that differ among clinical laboratories. The variability in viral load measurements makes interpretation of multicenter clinical trials data difficult. This study compares the current practices in CMV and EBV viral load testing at four large transplant centers participating in multicenter Clinical Trials in Organ Transplantation and the Clinical Trials in Organ Transplantation in Children (CTOT and CTOTC). Viral load testing was performed on well-defined viral preparations according to standard operating procedures at each site. Among centers, CMV viral load testing was accurate compared to WHO International Standards and within acceptable variation for this testing method. Epstein-Barr virus viral load data were more variable and less accurate despite the use of international standards. These data suggest that comparison of CMV, but not EBV, viral load measurements at these sites is possible using current assays and control standards. Standardization of these assays is facilitated using the WHO International Standards and will allow comparison of viral load results among transplant centers. Assay standardization must be performed prior to initiation of multicenter trials. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  15. An Information Management and Technology Laboratory in an Academic Health Center Library

    PubMed Central

    Peterson, Margaret G.E.; Brantz, Malcolm H.

    1984-01-01

    The aims and goals in setting up an Information Management and Technology Laboratory in the Lyman Maynard Stowe Library at the University of Connecticut Health Center are outlined. Health professionals have a chance in the Laboratory to try software and machines and acquaint themselves with some of the new technology. The Laboratory can save individual departments time, the necessity for extensive research and money and will be used to give students and staff experience in information management techniques.

  16. Epidemiological, clinical and laboratory findings of infectious keratitis at Mansoura Ophthalmic Center, Egypt

    PubMed Central

    Badawi, Amani E; Moemen, Dalia; El-Tantawy, Nora L

    2017-01-01

    AIM To analyze the epidemiological, clinical and laboratory findings of infectious keratitis. METHODS A retrospective study on cases of infective keratitis, attended our institution from Mar. 2013 to Feb. 2015, was done at Mansoura Ophthalmic Center, Egypt. Corneal scrapings were performed and processed for direct microscopy and culture in appropriate media using standard laboratory protocols. RESULTS Out of 245 patients enrolled for study, 247 corneal scrapings were obtained. Ocular trauma was the most common predisposing factor (51.4%), followed by diabetes mellitus (15.1%). Cultures were positive in 110 scraping samples (44.5%): 45.5% samples had pure fungal infection, 40% had pure bacterial infections and 10% had mixed fungal and bacterial growths. Acanthamoeba was detected in 5 (4.5%) samples. The most common fungal pathogen was Aspergillus spp. (41%). The most common bacterial isolates were Staphylococcus aureus (38.2%) and Pseudomonas aeruginosa (21.8%). CONCLUSION Incidence of fungal keratitis is high in our region. Therapeutic approach can initially be based on clinical features and sensitivity/resistance patterns. Microbiological research should direct the antimicrobial treatment. Antibiotic resistance to fluoroquinolones and aminoglycosides is an important consideration. PMID:28149778

  17. A Research Utilization Laboratory in a Comprehensive Rehabilitation Center. Final Report.

    ERIC Educational Resources Information Center

    Robinault, Isabel P.; Weisinger, Marvin

    The ICD Research Utilization Laboratory (ICD-RUL) at the Comprehensive Rehabilitation Center at Catholic University in Washington, D.C. acted as a facilitator for improving management practices of supervisors of vocationally impaired populations. Over a 10-year span, ICD-RUL developed two National Information Centers for disabled public assistance…

  18. 75 FR 34452 - Center for Drug Evaluation and Research Data Standards Plan; Availability for Comment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-17

    ... HUMAN SERVICES Food and Drug Administration Center for Drug Evaluation and Research Data Standards Plan... development of a comprehensive data standards program in the Center for Drug Evaluation and Research (CDER... Drug Information, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New...

  19. 78 FR 63999 - Notice of Vitamin D Standardization Program (VDSP) Symposium: Tools To Improve Laboratory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-25

    ... HUMAN SERVICES National Institutes of Health Notice of Vitamin D Standardization Program (VDSP... one-day symposium on November 14, 2013, to present information about the Vitamin D Standardization... standardize the laboratory measurement of vitamin D status worldwide. Standardization is essential to improve...

  20. 42 CFR 493.1407 - Standard; Laboratory director responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... testing; (2) Ensure that the physical plant and environmental conditions of the laboratory are appropriate... physical, chemical, and biological hazards; (3) Ensure that— (i) The test methodologies selected have the... functioning properly; (8) Ensure that reports of test results include pertinent information required...

  1. 42 CFR 493.1443 - Standard; Laboratory director qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... medicine or osteopathy in the State in which the laboratory is located; and (ii) Be certified in anatomic or clinical pathology, or both, by the American Board of Pathology or the American Osteopathic Board of Pathology or possess qualifications that are equivalent to those required for such certification...

  2. 42 CFR 493.1443 - Standard; Laboratory director qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... medicine or osteopathy in the State in which the laboratory is located; and (ii) Be certified in anatomic or clinical pathology, or both, by the American Board of Pathology or the American Osteopathic Board of Pathology or possess qualifications that are equivalent to those required for such certification...

  3. 42 CFR 493.1443 - Standard; Laboratory director qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... medicine or osteopathy in the State in which the laboratory is located; and (ii) Be certified in anatomic or clinical pathology, or both, by the American Board of Pathology or the American Osteopathic Board of Pathology or possess qualifications that are equivalent to those required for such certification...

  4. 42 CFR 493.1443 - Standard; Laboratory director qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... medicine or osteopathy in the State in which the laboratory is located; and (ii) Be certified in anatomic or clinical pathology, or both, by the American Board of Pathology or the American Osteopathic Board of Pathology or possess qualifications that are equivalent to those required for such certification...

  5. 48 CFR 1511.011-80 - Data standards for the transmission of laboratory measurement results.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... standards for the transmission of laboratory measurement results. The contracting officer shall insert the... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Data standards for the transmission of laboratory measurement results. 1511.011-80 Section 1511.011-80 Federal Acquisition Regulations...

  6. Frequency standards from government laboratories over the next 25 years

    NASA Technical Reports Server (NTRS)

    Maleki, L.

    1994-01-01

    Based on a number of considerations including projected needs, current status, future trends, and status of key technologies, an attempt is made to project the future of government supported frequency standards development in the next 25 years.

  7. Use of the National Committee for Clinical Laboratory Standards Guidelines for Disk Diffusion Susceptibility Testing in New York State Laboratories

    PubMed Central

    Kiehlbauch, Julia A.; Hannett, George E.; Salfinger, Max; Archinal, Wendy; Monserrat, Catherine; Carlyn, Cynthia

    2000-01-01

    Accurate antimicrobial susceptibility testing is vital for patient care and surveillance of emerging antimicrobial resistance. The National Committee for Clinical Laboratory Standards (NCCLS) outlines generally agreed upon guidelines for reliable and reproducible results. In January 1997 we surveyed 320 laboratories participating in the New York State Clinical Evaluation Program for General Bacteriology proficiency testing. Our survey addressed compliance with NCCLS susceptibility testing guidelines for bacterial species designated a problem (Staphylococcus aureus and Enterococcus species) or fastidious (Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria gonorrhoeae) organism. Specifically, we assessed compliance with guidelines for inoculum preparation, medium choice, number of disks per plate, and incubation conditions for disk diffusion tests. We also included length of incubation for S. aureus and Enterococcus species. We found overall compliance with the five characteristics listed above in 80 of 153 responding laboratories (50.6%) for S. aureus and 72 of 151 (47.7%) laboratories for Enterococcus species. The most common problem was an incubation time shortened to less than 24 h. Overall compliance with the first four characteristics was reported by 92 of 221 (41.6%) laboratories for S. pneumoniae, 49 of 163 (30.1%) laboratories for H. influenzae, and 11 of 77 (14.3%) laboratories for N. gonorrhoeae. Laboratories varied from NCCLS guidelines by placing an excess number of disks per plate. Laboratories also reported using alternative media for Enterococcus species, N. gonorrhoeae, and H. influenzae. This study demonstrates a need for education among clinical laboratories to increase compliance with NCCLS guidelines. PMID:10970381

  8. Emergency preparedness for genetics centers, laboratories, and patients: the Southeast Region Genetics Collaborative strategic plan.

    PubMed

    Andersson, Hans C; Perry, William; Bowdish, Bruce; Floyd-Browning, Phaidra

    2011-10-01

    Emergencies occur unpredictably and interrupt routine genetic care. The events after hurricanes Katrina and Rita have led to the recognition that a coherent plan is necessary to ensure continuity of operations for genetic centers and laboratories, including newborn screening. No geographic region is protected from the effects of a variety of potential emergencies. Regional and national efforts have begun to address the need for such preparedness, but a plan for ensuring continuity of operations by creating an emergency preparedness plan must be developed for each genetic center and laboratory, with attention to the interests of patients. This article describes the first steps in development of an emergency preparedness plan for individual centers.

  9. Illinois Occupational Skill Standards: Retail Garden Center Cluster.

    ERIC Educational Resources Information Center

    Illinois Occupational Skill Standards and Credentialing Council, Carbondale.

    These skill standards, developed through a consortium of educational and industry partners in Illinois, serve as guides to workforce preparation program providers to define content for their programs and to employers to establish the skills and standards necessary for job acquisition and performance. The skill standards include the following…

  10. The effects of calculator-based laboratories on standardized test scores

    NASA Astrophysics Data System (ADS)

    Stevens, Charlotte Bethany Rains

    Nationwide, the goal of providing a productive science and math education to our youth in today's educational institutions is centering itself around the technology being utilized in these classrooms. In this age of digital technology, educational software and calculator-based laboratories (CBL) have become significant devices in the teaching of science and math for many states across the United States. Among the technology, the Texas Instruments graphing calculator and Vernier Labpro interface, are among some of the calculator-based laboratories becoming increasingly popular among middle and high school science and math teachers in many school districts across this country. In Tennessee, however, it is reported that this type of technology is not regularly utilized at the student level in most high school science classrooms, especially in the area of Physical Science (Vernier, 2006). This research explored the effect of calculator based laboratory instruction on standardized test scores. The purpose of this study was to determine the effect of traditional teaching methods versus graphing calculator teaching methods on the state mandated End-of-Course (EOC) Physical Science exam based on ability, gender, and ethnicity. The sample included 187 total tenth and eleventh grade physical science students, 101 of which belonged to a control group and 87 of which belonged to the experimental group. Physical Science End-of-Course scores obtained from the Tennessee Department of Education during the spring of 2005 and the spring of 2006 were used to examine the hypotheses. The findings of this research study suggested the type of teaching method, traditional or calculator based, did not have an effect on standardized test scores. However, the students' ability level, as demonstrated on the End-of-Course test, had a significant effect on End-of-Course test scores. This study focused on a limited population of high school physical science students in the middle Tennessee

  11. U.S. Geological Survey Standard Reference Sample Project: Performance Evaluation of Analytical Laboratories

    USGS Publications Warehouse

    Long, H. Keith; Daddow, Richard L.; Farrar, Jerry W.

    1998-01-01

    Since 1962, the U.S. Geological Survey (USGS) has operated the Standard Reference Sample Project to evaluate the performance of USGS, cooperator, and contractor analytical laboratories that analyze chemical constituents of environmental samples. The laboratories are evaluated by using performance evaluation samples, called Standard Reference Samples (SRSs). SRSs are submitted to laboratories semi-annually for round-robin laboratory performance comparison purposes. Currently, approximately 100 laboratories are evaluated for their analytical performance on six SRSs for inorganic and nutrient constituents. As part of the SRS Project, a surplus of homogeneous, stable SRSs is maintained for purchase by USGS offices and participating laboratories for use in continuing quality-assurance and quality-control activities. Statistical evaluation of the laboratories results provides information to compare the analytical performance of the laboratories and to determine possible analytical deficiences and problems. SRS results also provide information on the bias and variability of different analytical methods used in the SRS analyses.

  12. A brave new animal for a brave new world: The British Laboratory Animals Bureau and the constitution of international standards of laboratory animal production and use, circa 1947-1968.

    PubMed

    Kirk, Robert G W

    2010-03-01

    In 1947 the Medical Research Council of Britain established the Laboratory Animals Bureau in order to develop national standards of animal production that would enable commercial producers better to provide for the needs of laboratory animal users. Under the directorship of William Lane-Petter, the bureau expanded well beyond this remit, pioneering a new discipline of "laboratory animal science" and becoming internationally known as a producer of pathogenically and genetically standardized laboratory animals. The work of this organization, later renamed the Laboratory Animals Centre, and of Lane-Petter did much to systematize worldwide standards for laboratory animal production and provision--for example, by prompting the formation of the International Committee on Laboratory Animals. This essay reconstructs how the bureau became an internationally recognized center of expertise and argues that standardization discourses within science are inherently internationalizing. It traces the dynamic co-constitution of standard laboratory animals alongside that of the identities of the users, producers, and regulators of laboratory animals. This process is shown to have brought into being a transnational community with shared conceptual understandings and material practices grounded in the materiality of the laboratory animal, conceived as an instrumental technology.

  13. Inter-laboratory variation in DNA damage using a standard comet assay protocol.

    PubMed

    Forchhammer, Lykke; Ersson, Clara; Loft, Steffen; Möller, Lennart; Godschalk, Roger W L; van Schooten, Frederik J; Jones, George D D; Higgins, Jennifer A; Cooke, Marcus; Mistry, Vilas; Karbaschi, Mahsa; Collins, Andrew R; Azqueta, Amaya; Phillips, David H; Sozeri, Osman; Routledge, Michael N; Nelson-Smith, Kirsty; Riso, Patrizia; Porrini, Marisa; Matullo, Giuseppe; Allione, Alessandra; Stępnik, Maciej; Steepnik, Maciej; Komorowska, Magdalena; Teixeira, João Paulo; Costa, Solange; Corcuera, Laura-Ana; López de Cerain, Adela; Laffon, Blanca; Valdiglesias, Vanessa; Møller, Peter

    2012-11-01

    There are substantial inter-laboratory variations in the levels of DNA damage measured by the comet assay. The aim of this study was to investigate whether adherence to a standard comet assay protocol would reduce inter-laboratory variation in reported values of DNA damage. Fourteen laboratories determined the baseline level of DNA strand breaks (SBs)/alkaline labile sites and formamidopyrimidine DNA glycosylase (FPG)-sensitive sites in coded samples of mononuclear blood cells (MNBCs) from healthy volunteers. There were technical problems in seven laboratories in adopting the standard protocol, which were not related to the level of experience. Therefore, the inter-laboratory variation in DNA damage was only analysed using the results from laboratories that had obtained complete data with the standard comet assay protocol. This analysis showed that the differences between reported levels of DNA SBs/alkaline labile sites in MNBCs were not reduced by applying the standard assay protocol as compared with the laboratory's own protocol. There was large inter-laboratory variation in FPG-sensitive sites by the laboratory-specific protocol and the variation was reduced when the samples were analysed by the standard protocol. The SBs and FPG-sensitive sites were measured in the same experiment, indicating that the large spread in the latter lesions was the main reason for the reduced inter-laboratory variation. However, it remains worrying that half of the participating laboratories obtained poor results using the standard procedure. This study indicates that future comet assay validation trials should take steps to evaluate the implementation of standard procedures in participating laboratories.

  14. A new approach for laboratory exercise of pathophysiology in China based on student-centered learning.

    PubMed

    Chen, Jian; Zhou, Junhai; Sun, Li; Wu, Qiuhui; Lu, Huiling; Tian, Jing

    2015-06-01

    Student-centered learning is generally defined as any instructional method that purportedly engages students in active learning and critical thinking. The student-centered method of teaching moves the focus from teaching to learning, from the teachers' conveying course concepts via lecture to the understanding of concepts by students. The student-centered method has been used extensively in lecture courses in China; however, there is little evidence of its use in laboratory courses. The purpose of the present study was to describe the implementation of a student-centered method in a pathophysiology laboratory course. The use of student-centered learning strategies in an undergraduate laboratory course was well received by both students and teachers. Here, students had to take on responsibility for their own learning and, thus, became more accountable. Moreover, they reported increased active learning, skill development, information collection, and retention. In addition, mean scores for the quiz were significantly higher in the student-centered method compared with the traditional teaching method. The shift from teacher-centered delivery to a student-centered model led to a positive change, in which the learners drove the process and were guided, not directed, by the teacher. Copyright © 2015 The American Physiological Society.

  15. Improving the life science (biology) laboratory education experience: From an instructor-centered to a learner-centered educational environment

    NASA Astrophysics Data System (ADS)

    Stevens, Marcella Liffick

    The component parts of the educational experience in a freshman biology laboratory course could be improved if the knowledge, skills, and personality of the students could be integrated with the instructor's. Lack of integration of instruction with learning often results in students unwilling or unable to learn content and to transfer it to future courses. This research examined the component parts of instruction and learning for a freshman biology laboratory class and provided an alternative approach to the traditional experience in this lab. Outcome assessment revealed that students experiencing a learner-centered lab responded differently to instruction than students in the traditional lab did and expressed more of a learning orientation and awareness. Not all methods used were successful but course evaluations demonstrated an increased awareness of the learning process among students in the learner-centered lab. The alternative group indicated differences specifically directed toward learning, more often than the traditional group did.

  16. Accreditation Standards for University and College Counseling Centers.

    ERIC Educational Resources Information Center

    Boyd, Vivian; Hattauer, Edward; Brandel, Irvin W.; Buckles, Nancy; Davidshofer, Charles; Deakin, Spencer; Erskine, Charlene; Hurley, George; Locher, Linda; Piorkowski, Geraldine; Simono, R. B.; Spivack, James; Steel, Catherine M.

    2003-01-01

    The accreditation standards outlined in the article are used by the International Association of Counseling Services as the basis for the formal accreditation of college and university counseling programs throughout the United States, Canada, and Australia. They reflect the program elements and practice standards that are deemed essential in a…

  17. Space and Missile Systems Center Compliance Specifications and Standards

    DTIC Science & Technology

    2015-07-31

    Information Technology Association 3 Formerly known as Society of Automotive Engineers Revisions to the SMC Compliance Standards 15 Line # Document Number...Technology; Interoperability DISR (current version) DOD Information Technology Standards Registry (DISR) n/a Updates 3 times per year; verify current...

  18. Parachute drawing standards currently in use at Sandia National Laboratories

    SciTech Connect

    Ronquillo, K.L.

    1988-01-01

    A need exists in the parachute industry for a standard method of defining and guiding the formation of textile drawings. Textile drawings have their own unique problems associated with their development. Unlike mechanical parts, textiles have no mass in cross section. Therefore, a cross-sectioned view has no hash marks. Hidden views are not usually incorporated in textile drawings as they are easily confused with stitch formations. Side views of textile parts are depicted using only one line to show thickness. This report will address these and other unique drawing problems associated with the development of parachute drawings and will offer, as a base, standards to be used when developing these drawings. 21 figs.

  19. [The analytical reliability of clinical laboratory information and role of the standards in its support].

    PubMed

    Men'shikov, V V

    2012-12-01

    The article deals with the factors impacting the reliability of clinical laboratory information. The differences of qualities of laboratory analysis tools produced by various manufacturers are discussed. These characteristics are the causes of discrepancy of the results of laboratory analyses of the same analite. The role of the reference system in supporting the comparability of laboratory analysis results is demonstrated. The project of national standard is presented to regulate the requirements to standards and calibrators for analysis of qualitative and non-metrical characteristics of components of biomaterials.

  20. Economic Analysis of Requests for Laboratory Tests in Primary Health Care Centers

    PubMed Central

    Zunic, Lejla

    2012-01-01

    Introduction: Operation of the Primary health care center and Medical-biochemical laboratories depends on the number of performed laboratory tests. The number of unnecessary tests significantly affect the operation of health institutions. Material and methods: We analyzed the 1000 requests for laboratory tests at the Primary Health Care Centre in Gracanica from primary care units. Based on the requests for laboratory diagnostics advisable diagnoses from primary health care unit in the Primary Health Care Center (PHC) we made an economic analysis of the total required laboratory tests in the requests for laboratory diagnosis. Incorporating the economic analysis of laboratory tests in requests for laboratory diagnosis by doctors in primary health care (PHC) and the economic analysis of laboratory tests by the disease in primary health care. Results: The economic value of 5333 laboratory tests was 84 312 points (1 point is 0.80 KM). Of the total value of the index score requirements of GPs are 44, 1%, the requirement of family doctors account for 40% and requirements of other specialists make up 15, 9%.. Discussion: In the requests of the PHC units for laboratory tests are required all levels of services: urine, CBC, SE, glucose, bilirubine, ALT, AST, AF, CK, cholesterol, HDL chol., triglicerdes, creatinine, urea, uric acid, CRP, fibrinogen, calcium and phosphorus. The following requests are the most common laboratory tests: urine, CBC, blood glucose, cholesterol, triglycerides, aminotransferases, creatinine, urea. The doctors in family practice most often requested: blood glucose, urine, CBC, SE, TGL. , Chol., ALT, AST, creatinine and urea. General practitioners were demanding more cholesterol and triglycerides, and family medicine doctors were demanding less cholesterol and triglycerides and more often CRP, fibrinogen, ALT, AST, what from the level of economic cost analysis rises the issue whether this was justified? PMID:23322950

  1. Wellness Center use at Los Alamos National Laboratory: a descriptive study

    SciTech Connect

    Wiggs, L.D.; Wilkinson, G.S.; Weber, C.

    1985-10-01

    This study describes employee participation during the first six months of the Los Alamos National Laboratory's corporate Wellness Program. We describe temporal patterns of use, preferred activities, frequency of use, and characteristics of employees participating in Wellness activities. Characteristics of Wellness participants are compared with characteristics of the Laboratory population. During this period the Wellness Center, a multi-use facility that houses Wellness Program activities, had 17,352 visits. Employees visiting the Wellness Center were typical of the Laboratory population in their racial and ethnic characteristics, but different in their sex and age composition. Wellness participants were younger and more likely to be female than the Laboratory population. 6 refs., 19 tabs.

  2. Meeting Academic Standards through Peer Dialogue at Literacy Centers

    ERIC Educational Resources Information Center

    Maurer, Caroline

    2010-01-01

    Literacy centers are widely used by teachers seen as being effective in promoting literacy (Pressley, Rankin, & Yokoi, 2000); yet little research has been completed on how or why they are effective. Based on the social cultural constructivist theory posited by Vygotsky (1978), and research theories of Dyson (1993), the peer dialogue at the…

  3. Meeting Academic Standards through Peer Dialogue at Literacy Centers

    ERIC Educational Resources Information Center

    Maurer, Caroline

    2010-01-01

    Literacy centers are widely used by teachers seen as being effective in promoting literacy (Pressley, Rankin, & Yokoi, 2000); yet little research has been completed on how or why they are effective. Based on the social cultural constructivist theory posited by Vygotsky (1978), and research theories of Dyson (1993), the peer dialogue at the…

  4. Applied human factors research at the NASA Johnson Space Center Human-Computer Interaction Laboratory

    NASA Technical Reports Server (NTRS)

    Rudisill, Marianne; Mckay, Timothy D.

    1990-01-01

    The applied human factors research program performed at the NASA Johnson Space Center's Human-Computer Interaction Laboratory is discussed. Research is conducted to advance knowledge in human interaction with computer systems during space crew tasks. In addition, the Laboratory is directly involved in the specification of the human-computer interface (HCI) for space systems in development (e.g., Space Station Freedom) and is providing guidelines and support for HCI design to current and future space missions.

  5. Applied human factors research at the NASA Johnson Space Center Human-Computer Interaction Laboratory

    NASA Technical Reports Server (NTRS)

    Rudisill, Marianne; Mckay, Timothy D.

    1990-01-01

    The applied human factors research program performed at the NASA Johnson Space Center's Human-Computer Interaction Laboratory is discussed. Research is conducted to advance knowledge in human interaction with computer systems during space crew tasks. In addition, the Laboratory is directly involved in the specification of the human-computer interface (HCI) for space systems in development (e.g., Space Station Freedom) and is providing guidelines and support for HCI design to current and future space missions.

  6. [Standardization of the terminology of the academic medical centers and biomedical research centers, in the English language, for journal article sending].

    PubMed

    Hochman, Bernardo; Locali, Rafael Fagionato; Oliveira Filho, Renato Santos de; Oliveira, Ricardo Leão de; Goldenberg, Saul; Ferreira, Lydia Masako

    2006-01-01

    To suggest a standardization, in the English language, the formatting of the citation of the research centers. From three more recent publications of the first 20 journals available in Brazilian Portal of Scientific Information - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), with bigger factor of impact during the year of 2004, according of information in ISI Web of Knowledge Journal Citation Reports database in biennium 2004-2005, had extracted the formats of citations of the research centers. An analogy to the institutional hierarchie step of the Federal University of Sao Paulo (UNIFESP) was carried out, and the formats most frequent, in the English language, had been adopted as standard to be suggested to cite the research centers for sending articles. In relation to the citation "Departamento", was standardized "Department of ..." (being "..." the name in English of the Department), to the citation "Programa de Pós-Graduação" "... Program", "Disciplina" "Division of ...", "Orgãos, Grupos e Associações" "... Group ", "Setor" "Section of...", "Centro" "Center for ...", "Unidade" "... Unit ", "Instituto" "Institute of ...", "Laboratório" "Laboratory of ..." and "Grupo" "Group of ...".

  7. Identification of a Widespread Palmitoylethanolamide Contamination in Standard Laboratory Glassware

    PubMed Central

    Angelini, Roberto; Argueta, Donovan A.; Piomelli, Daniele; DiPatrizio, Nicholas V.

    2017-01-01

    Abstract Introduction: Fatty acid ethanolamides (FAEs) are a family of lipid mediators that participate in a host of biological functions. Procedures for the quantitative analysis of FAEs include organic solvent extraction from biological matrices (e.g., blood), followed by purification and subsequent quantitation by liquid chromatography–mass spectrometry (LC/MS) or gas chromatography–mass spectrometry. During the validation process of a new method for LC/MS analysis of FAEs in biological samples, we observed unusually high levels of the FAE, palmitoylethanolamide (PEA), in blank samples that did not contain any biological material. Materials and Methods: We investigated a possible source of this PEA artifact via liquid chromatography coupled to tandem mass spectrometry, as well as accurate mass analysis. Results: We found that high levels of a contaminant indistinguishable from PEA is present in new 5.75″ glass Pasteur pipettes, which are routinely used by laboratories to carry out lipid extractions. This artifact might account for discrepancies found in the literature regarding PEA levels in human blood serum and other tissues. Conclusions: It is recommended to take into account this pitfall by analyzing potential contamination of the disposable glassware during the validation process of any method used for analysis of FAEs. PMID:28861512

  8. Highlighting High Performance: National Renewable Energy Laboratory's Visitors Center, Golden, Colorado

    SciTech Connect

    Burgert, S.

    2001-06-19

    The National Renewable Energy Laboratory Visitors Center, also known as the Dan Schaefer Federal Building, is a high-performance building located in Golden, Colorado. The 6,400-square-foot building incorporates passive solar heating, energy-efficient lighting, an evaporative cooling system, and other technologies to minimize energy costs and environmental impact. The Visitors Center displays a variety of interactive exhibits on energy efficiency and renewable energy, and the building includes an auditorium, a public reading room, and office space.

  9. New HPV Serology Laboratory Aims to Standardize Assays and Contribute to Vaccine Implementation and Access | FNLCR

    Cancer.gov

    A new international initiative, led by scientists at the Frederick National Laboratory for Cancer Research and several other institutions, is being launched to provide expertise and leadership on the development, validation, and standardization of hu

  10. NATIONAL ENVIRONMENTAL LABORATORY ACCREDITATION CONFERENCE; CONSTITUTION, BYLAWS AND STANDARDS: APPROVED MAY 25, 2001

    EPA Science Inventory

    The principles and operating procedures for the National Environmental Laboratory Accreditation Conference (NELAC) are contained in the NELAC Constitution and Bylaws. The major portion of this document (standards) contains detailed requirements for accrediting environmental labo...

  11. NATIONAL ENVIRONMENTAL LABORATORY ACCREDITATION CONFERENCE; CONSTITUTION, BYLAWS AND STANDARDS: APPROVED MAY 25, 2001

    EPA Science Inventory

    The principles and operating procedures for the National Environmental Laboratory Accreditation Conference (NELAC) are contained in the NELAC Constitution and Bylaws. The major portion of this document (standards) contains detailed requirements for accrediting environmental labo...

  12. A new standard genetic map for the laboratory mouse.

    PubMed

    Cox, Allison; Ackert-Bicknell, Cheryl L; Dumont, Beth L; Ding, Yueming; Bell, Jordana Tzenova; Brockmann, Gudrun A; Wergedal, Jon E; Bult, Carol; Paigen, Beverly; Flint, Jonathan; Tsaih, Shirng-Wern; Churchill, Gary A; Broman, Karl W

    2009-08-01

    Genetic maps provide a means to estimate the probability of the co-inheritance of linked loci as they are transmitted across generations in both experimental and natural populations. However, in the age of whole-genome sequences, physical distances measured in base pairs of DNA provide the standard coordinates for navigating the myriad features of genomes. Although genetic and physical maps are colinear, there are well-characterized and sometimes dramatic heterogeneities in the average frequency of meiotic recombination events that occur along the physical extent of chromosomes. There also are documented differences in the recombination landscape between the two sexes. We have revisited high-resolution genetic map data from a large heterogeneous mouse population and have constructed a revised genetic map of the mouse genome, incorporating 10,195 single nucleotide polymorphisms using a set of 47 families comprising 3546 meioses. The revised map provides a different picture of recombination in the mouse from that reported previously. We have further integrated the genetic and physical maps of the genome and incorporated SSLP markers from other genetic maps into this new framework. We demonstrate that utilization of the revised genetic map improves QTL mapping, partially due to the resolution of previously undetected errors in marker ordering along the chromosome.

  13. Report on the Project for Establishment of the Standardized Korean Laboratory Terminology Database, 2015.

    PubMed

    Jung, Bo Kyeung; Kim, Jeeyong; Cho, Chi Hyun; Kim, Ju Yeon; Nam, Myung Hyun; Shin, Bong Kyung; Rho, Eun Youn; Kim, Sollip; Sung, Heungsup; Kim, Shinyoung; Ki, Chang Seok; Park, Min Jung; Lee, Kap No; Yoon, Soo Young

    2017-04-01

    The National Health Information Standards Committee was established in 2004 in Korea. The practical subcommittee for laboratory test terminology was placed in charge of standardizing laboratory medicine terminology in Korean. We aimed to establish a standardized Korean laboratory terminology database, Korea-Logical Observation Identifier Names and Codes (K-LOINC) based on former products sponsored by this committee. The primary product was revised based on the opinions of specialists. Next, we mapped the electronic data interchange (EDI) codes that were revised in 2014, to the corresponding K-LOINC. We established a database of synonyms, including the laboratory codes of three reference laboratories and four tertiary hospitals in Korea. Furthermore, we supplemented the clinical microbiology section of K-LOINC using an alternative mapping strategy. We investigated other systems that utilize laboratory codes in order to investigate the compatibility of K-LOINC with statistical standards for a number of tests. A total of 48,990 laboratory codes were adopted (21,539 new and 16,330 revised). All of the LOINC synonyms were translated into Korean, and 39,347 Korean synonyms were added. Moreover, 21,773 synonyms were added from reference laboratories and tertiary hospitals. Alternative strategies were established for mapping within the microbiology domain. When we applied these to a smaller hospital, the mapping rate was successfully increased. Finally, we confirmed K-LOINC compatibility with other statistical standards, including a newly proposed EDI code system. This project successfully established an up-to-date standardized Korean laboratory terminology database, as well as an updated EDI mapping to facilitate the introduction of standard terminology into institutions. © 2017 The Korean Academy of Medical Sciences.

  14. Report on the Project for Establishment of the Standardized Korean Laboratory Terminology Database, 2015

    PubMed Central

    Lee, Kap-No

    2017-01-01

    The National Health Information Standards Committee was established in 2004 in Korea. The practical subcommittee for laboratory test terminology was placed in charge of standardizing laboratory medicine terminology in Korean. We aimed to establish a standardized Korean laboratory terminology database, Korea-Logical Observation Identifier Names and Codes (K-LOINC) based on former products sponsored by this committee. The primary product was revised based on the opinions of specialists. Next, we mapped the electronic data interchange (EDI) codes that were revised in 2014, to the corresponding K-LOINC. We established a database of synonyms, including the laboratory codes of three reference laboratories and four tertiary hospitals in Korea. Furthermore, we supplemented the clinical microbiology section of K-LOINC using an alternative mapping strategy. We investigated other systems that utilize laboratory codes in order to investigate the compatibility of K-LOINC with statistical standards for a number of tests. A total of 48,990 laboratory codes were adopted (21,539 new and 16,330 revised). All of the LOINC synonyms were translated into Korean, and 39,347 Korean synonyms were added. Moreover, 21,773 synonyms were added from reference laboratories and tertiary hospitals. Alternative strategies were established for mapping within the microbiology domain. When we applied these to a smaller hospital, the mapping rate was successfully increased. Finally, we confirmed K-LOINC compatibility with other statistical standards, including a newly proposed EDI code system. This project successfully established an up-to-date standardized Korean laboratory terminology database, as well as an updated EDI mapping to facilitate the introduction of standard terminology into institutions. PMID:28244299

  15. The Synergistic Attributes of Library Media Center Standards

    ERIC Educational Resources Information Center

    Misakian, Jo Ellen Priest

    2006-01-01

    Designing curricula around the standards, with clearly delineated strategies, expectations, and evaluative procedures, is thought to assure that growth in student achievement may be tracked. While this process can sometimes be nebulous, one thing is certain: clearly understanding what is involved in reaching a degree of excellence and determining…

  16. Los Alamos National Laboratory standard nuclear material container

    SciTech Connect

    Stone, Timothy A

    2009-01-01

    The shut down of United States (U.S.) nuclear-weapons production activities in the early 1990s left large quantities of nuclear materials throughout the U.S. Department of Energy (DOE) complex in forms not intended for long-term storage. In May 1994, the Defense Nuclear Facilities Safety Board (DNFSB) issued Recommendation 94-1, which called for the stabilization and disposition of 'thousands of containers of plutonium-bearing liquids and solids' in the DOE complex, including LANL in the nuclear-weapons-manufacturing pipeline when manufacturing ended. This resulted in the development of the 3013 standard with container requirements for long term storage (up to 50 years). A follow on was the Criteria For Interim Storage of Plutonium Bearing Materials, Charles B. Curtis, in 1996 to address storage other than the 3013 standard for shorter time frames. In January 2000, the DNFSB issued Recommendation 2000-1, which stated the need for LANL to repackage 'about one ton of plutonium metal and oxide,' declared excess to Defense Program (DP) needs. The DNFSB recommended that LANL 'stabilize and seal within welded containers with an inert atmosphere the plutonium oxides ... which are not yet in states conforming to the long-term storage envisaged by DOE-STD-3013,' and that they '... enclose existing and newly-generated legacy plutonium metal in sealed containers with an inert atmosphere,' and 'remediate and/or safely store the various residues.' Recommendation 2000-1, while adding to the number of items needing remediation, also reiterated the need to address remaining items from 1994-1 in a timely fashion. Since timetables slipped, the DNFSB recommended that the Complex 'prioritize and schedule tasks according to the consideration of risks.' In March 2005, the DNFSB issued Recommendation 2005-1. This recommendation addresses the need for a consistent set of criteria across the DOE complex for the interim storage of nuclear material packaged outside an engineered barrier. The

  17. Metrological traceability - a concept for standardization in laboratory medicine.

    PubMed

    Siekmann, Lothar

    2013-05-01

    The concept of measurement traceability provides the most important strategy in achieving standardization in laboratory medicine aimed at equivalent measurement results regardless of the principle of measurement, the method, the actual measurement procedure (test kit) and the laboratory where analyses are carried out.

  18. Inter-laboratory validation of standardized method to determine permeability of plastic films

    USDA-ARS?s Scientific Manuscript database

    To support regulations controlling soil fumigation, we are standardizing the laboratory method we developed to measure the permeability of plastic films to fumigant vapors. The method was validated using an inter-laboratory comparison with 7 participants. Each participant evaluated the mass transfer...

  19. 7 CFR 91.37 - Standard hourly fee rate for laboratory testing, analysis, and other services.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... applicant will be assessed a fee which covers the costs to the Science and Technology program for the... standard hourly fee rate in this section for the individual laboratory analyses cover the costs of Science and Technology laboratory services, including issuance of certificates and personnel and overhead...

  20. 7 CFR 91.37 - Standard hourly fee rate for laboratory testing, analysis, and other services.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... standard hourly fee rate in this section for the individual laboratory analyses cover the costs of Science... processed commodity products. The new fiscal year for Science and Technology Programs commences on October 1... distribution to Science and Technology's constituents and stakeholders by the individual Laboratory Directors...

  1. 7 CFR 91.37 - Standard hourly fee rate for laboratory testing, analysis, and other services.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... standard hourly fee rate in this section for the individual laboratory analyses cover the costs of Science... processed commodity products. The new fiscal year for Science and Technology Programs commences on October 1... distribution to Science and Technology's constituents and stakeholders by the individual Laboratory Directors...

  2. 7 CFR 91.37 - Standard hourly fee rate for laboratory testing, analysis, and other services.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... standard hourly fee rate in this section for the individual laboratory analyses cover the costs of Science... processed commodity products. The new fiscal year for Science and Technology Programs commences on October 1... distribution to Science and Technology's constituents and stakeholders by the individual Laboratory Directors...

  3. FJ44 Turbofan Engine Test at NASA Glenn Research Center's Aero-Acoustic Propulsion Laboratory

    NASA Technical Reports Server (NTRS)

    Lauer, Joel T.; McAllister, Joseph; Loew, Raymond A.; Sutliff, Daniel L.; Harley, Thomas C.

    2009-01-01

    A Williams International FJ44-3A 3000-lb thrust class turbofan engine was tested in the NASA Glenn Research Center s Aero-Acoustic Propulsion Laboratory. This report presents the test set-up and documents the test conditions. Farfield directivity, in-duct unsteady pressures, duct mode data, and phased-array data were taken and are reported separately.

  4. The Impact of Educational R & D Centers and Laboratories: An Analysis of Effective Organizational Strategies.

    ERIC Educational Resources Information Center

    Baldridge, J. Victor; Johnson, Rudolph

    The purpose of this research was to study the link between effective management strategies and the impact of educational research and development. The 19 R & D Centers and Regional Laboratories of the United States Office of Education were selected as the focal organizations for analysis. Using document analysis and interviews, the researchers…

  5. Scientific involvement in Skylab by the Space Sciences Laboratory of the Marshall Space Flight Center

    NASA Technical Reports Server (NTRS)

    Winkler, C. E. (Editor)

    1973-01-01

    The involvement of the Marshall Space Flight Center's Space Sciences Laboratory in the Skylab program from the early feasibility studies through the analysis and publication of flight scientific and technical results is described. This includes mission operations support, the Apollo telescope mount, materials science/manufacturing in space, optical contamination, environmental and thermal criteria, and several corollary measurements and experiments.

  6. Center for Materials Science, Los Alamos National Laboratory. Status report, October 1, 1990--September 30, 1991

    SciTech Connect

    Parkin, D.M.; Boring, A.M.

    1991-10-01

    This report summarizes the progress of the Center for Materials Science (CMS) from October 1, 1990 to September 30, 1991, and is the nineth such annual report. It has been a year of remarkable progress in building the programs of the Center. The extent of this progress is described in detail. The CMS was established to enhance the contribution of materials science and technology to the Laboratory`s defense, energy and scientific missions, and the Laboratory. In carrying out these responsibilities it has accepted four demanding missions: (1) Build a core group of highly rated, established materials scientists and solid state physicists. (2) Promote and support top quality, interdisciplinary materials research programs at Los Alamos. (3) Strengthen the interactions of materials science and Los Alamos with the external materials science community. and (4) Establish and maintain modern materials research facilities in a readily accessible, central location.

  7. Improving consistency in large laboratory courses: a design for a standardized practical exam.

    PubMed

    Chen, Xinnian; Graesser, Donnasue; Sah, Megha

    2015-06-01

    Laboratory courses serve as important gateways to science, technology, engineering, and mathematics education. One of the challenges in assessing laboratory learning is to conduct meaningful and standardized practical exams, especially for large multisection laboratory courses. Laboratory practical exams in life sciences courses are frequently administered by asking students to move from station to station to answer questions, apply knowledge gained during laboratory experiments, interpret data, and identify various tissues and organs using various microscopic and gross specimens. This approach puts a stringent time limit on all questions regardless of the level of difficulty and also invariably increases the potential risk of cheating. To avoid potential cheating in laboratory courses with multiple sections, the setup for practical exams is often changed in some way between sections. In laboratory courses with multiple instructors or teaching assistants, practical exams may be handled inconsistently among different laboratory sections, due to differences in background knowledge, perceptions of the laboratory goals, or prior teaching experience. In this article, we describe a design for a laboratory practical exam that aims to align the assessment questions with well-defined laboratory learning objectives and improve the consistency among all laboratory sections. Copyright © 2015 The American Physiological Society.

  8. PNL audit report/corrective action responses of Westinghouse Standards Laboratory

    SciTech Connect

    Harrison, K.E.; Worden, L.M.

    1993-06-01

    This report is a collection of audit findings and corrective action responses to the Battelle Pacific Northwest Laboratory quality assurance verification of the Westinghouse Hanford Company (WHC) Standards Laboratory. Included in this document are meeting attendance records and copies of written correspondences concerning the audit. The document is roughly divided into three sections: a set of initial reports describing preparation of this corrective action document; reports pertaining to corrective action; and audit report records. Recent turnover of management at WHC Standards Laboratory was a contributing factor in completing this corrective action.

  9. 76 FR 9578 - Clinical Laboratory Improvement Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-18

    ... HUMAN SERVICES Centers for Disease Control and Prevention Clinical Laboratory Improvement Advisory... Additional Information: Nancy Anderson, Chief, Laboratory Practice Standards Branch, Division of Laboratory Science and Standards, Laboratory Science, Policy and Practice Program Office, Office of...

  10. National Renewable Energy Laboratory's Hydrogen Technologies and Systems Center is Helping to Facilitate the Transition to a New Energy Future

    SciTech Connect

    Not Available

    2011-01-01

    The Hydrogen Technologies and Systems Center (HTSC) at the U.S. Department of Energy's (DOE) National Renewable Energy Laboratory (NREL) uses a systems engineering and integration approach to hydrogen research and development to help the United States make the transition to a new energy future - a future built on diverse and abundant domestic renewable resources and integrated hydrogen systems. Research focuses on renewable hydrogen production, delivery, and storage; fuel cells and fuel cell manufacturing; technology validation; safety, codes, and standards; analysis; education; and market transformation. Hydrogen can be used in fuel cells to power vehicles and to provide electricity and heat for homes and offices. This flexibility, combined with our increasing demand for energy, opens the door for hydrogen power systems. HTSC collaborates with DOE, other government agencies, industry, communities, universities, national laboratories, and other stakeholders to promote a clean and secure energy future.

  11. Standardization of Hemagglutination Inhibition Assay for Influenza Serology Allows for High Reproducibility between Laboratories

    PubMed Central

    Zacour, Mary; Ward, Brian J.; Brewer, Angela; Tang, Patrick; Boivin, Guy; Li, Yan; Warhuus, Michelle; McNeil, Shelly A.; LeBlanc, Jason J.

    2016-01-01

    Standardization of the hemagglutination inhibition (HAI) assay for influenza serology is challenging. Poor reproducibility of HAI results from one laboratory to another is widely cited, limiting comparisons between candidate vaccines in different clinical trials and posing challenges for licensing authorities. In this study, we standardized HAI assay materials, methods, and interpretive criteria across five geographically dispersed laboratories of a multidisciplinary influenza research network and then evaluated intralaboratory and interlaboratory variations in HAI titers by repeatedly testing standardized panels of human serum samples. Duplicate precision and reproducibility from comparisons between assays within laboratories were 99.8% (99.2% to 100%) and 98.0% (93.3% to 100%), respectively. The results for 98.9% (95% to 100%) of the samples were within 2-fold of all-laboratory consensus titers, and the results for 94.3% (85% to 100%) of the samples were within 2-fold of our reference laboratory data. Low-titer samples showed the greatest variability in comparisons between assays and between sites. Classification of seroprotection (titer ≥ 40) was accurate in 93.6% or 89.5% of cases in comparison to the consensus or reference laboratory classification, respectively. This study showed that with carefully chosen standardization processes, high reproducibility of HAI results between laboratories is indeed achievable. PMID:26818953

  12. 40 CFR 262.103 - What is the scope of the laboratory environmental management standard?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 27 2013-07-01 2013-07-01 false What is the scope of the laboratory environmental management standard? 262.103 Section 262.103 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS...

  13. 40 CFR 262.103 - What is the scope of the laboratory environmental management standard?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false What is the scope of the laboratory environmental management standard? 262.103 Section 262.103 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE...

  14. 40 CFR 262.103 - What is the scope of the laboratory environmental management standard?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 26 2011-07-01 2011-07-01 false What is the scope of the laboratory environmental management standard? 262.103 Section 262.103 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE...

  15. Creating Cost-Effective DNA Size Standards for Use in Teaching and Research Laboratories

    ERIC Educational Resources Information Center

    Shultz, Jeff

    2011-01-01

    I have devised a method with which a molecular size standard can be readily manufactured using Lambda DNA and PCR. This method allows the production of specific sized DNA fragments and is easily performed in a standard molecular biology laboratory. The material required to create these markers can also be used to provide a highly robust and…

  16. [The challenges of standardization in clinical diagnostic laboratories of medical organizations].

    PubMed

    Men'shikov, V V

    2013-04-01

    The generalized data concerning the conditions of application of regulations of national standards in clinical diagnostic laboratories of medical organizations is presented. The primary information was provided by 14 regions of 6 federal administrative okrugs of Russia. The causes of challenges of application of requirements of standards are presented. They are mostly related with insufficient financial support, lacking of manpower, difficulties with reagents supply, inadequate technical maintenance of devices and absence of support of administration of medical organizations. The recommendations are formulated concerning the necessity of publishing the document of Minzdrav of Russia to determine the need in application of standards in laboratory practice.

  17. Systems integration for the Kennedy Space Center (KSC) Robotics Applications Development Laboratory (RADL)

    NASA Technical Reports Server (NTRS)

    Davis, V. Leon; Nordeen, Ross

    1988-01-01

    A laboratory for developing robotics technology for hazardous and repetitive Shuttle and payload processing activities is discussed. An overview of the computer hardware and software responsible for integrating the laboratory systems is given. The center's anthropomorphic robot is placed on a track allowing it to be moved to different stations. Various aspects of the laboratory equipment are described, including industrial robot arm control, smart systems integration, the supervisory computer, programmable process controller, real-time tracking controller, image processing hardware, and control display graphics. Topics of research include: automated loading and unloading of hypergolics for space vehicles and payloads; the use of mobile robotics for security, fire fighting, and hazardous spill operations; nondestructive testing for SRB joint and seal verification; Shuttle Orbiter radiator damage inspection; and Orbiter contour measurements. The possibility of expanding the laboratory in the future is examined.

  18. Automating the Analytical Laboratories Section, Lewis Research Center, National Aeronautics and Space Administration: A feasibility study

    NASA Technical Reports Server (NTRS)

    Boyle, W. G.; Barton, G. W.

    1979-01-01

    The feasibility of computerized automation of the Analytical Laboratories Section at NASA's Lewis Research Center was considered. Since that laboratory's duties are not routine, the automation goals were set with that in mind. Four instruments were selected as the most likely automation candidates: an atomic absorption spectrophotometer, an emission spectrometer, an X-ray fluorescence spectrometer, and an X-ray diffraction unit. Two options for computer automation were described: a time-shared central computer and a system with microcomputers for each instrument connected to a central computer. A third option, presented for future planning, expands the microcomputer version. Costs and benefits for each option were considered. It was concluded that the microcomputer version best fits the goals and duties of the laboratory and that such an automted system is needed to meet the laboratory's future requirements.

  19. Systems integration for the Kennedy Space Center (KSC) Robotics Applications Development Laboratory (RADL)

    NASA Technical Reports Server (NTRS)

    Davis, V. Leon; Nordeen, Ross

    1988-01-01

    A laboratory for developing robotics technology for hazardous and repetitive Shuttle and payload processing activities is discussed. An overview of the computer hardware and software responsible for integrating the laboratory systems is given. The center's anthropomorphic robot is placed on a track allowing it to be moved to different stations. Various aspects of the laboratory equipment are described, including industrial robot arm control, smart systems integration, the supervisory computer, programmable process controller, real-time tracking controller, image processing hardware, and control display graphics. Topics of research include: automated loading and unloading of hypergolics for space vehicles and payloads; the use of mobile robotics for security, fire fighting, and hazardous spill operations; nondestructive testing for SRB joint and seal verification; Shuttle Orbiter radiator damage inspection; and Orbiter contour measurements. The possibility of expanding the laboratory in the future is examined.

  20. Implementing an integrated standards-based management system to ensure compliance at Los Alamos National Laboratory

    SciTech Connect

    Hjeresen, D.; Roybal, S.; Bertino, P.; Gherman, C.; Hosteny, B.

    1995-03-01

    Los Alamos National Laboratory (LANL or the Laboratory) is developing and implementing a comprehensive, Integrated Standards-Based Management System (ISBMS) to enhance environmental, safety, and health (ESH) compliance efforts and streamline management of ESH throughout the Laboratory. The Laboratory recognizes that to be competitive in today`s business environment and attractive to potential Partnerships, Laboratory operations must be efficient and cost-effective. The Laboratory also realizes potential growth opportunities for developing ESH as a strength in providing new or improved services to its customers. Overall, the Laboratory desires to establish and build upon an ESH management system which ensures continuous improvement in protecting public health and safety and the environment and which fosters a working relationship with stakeholders. A team of process experts from the LANL Environmental Management (EM) Program Office, worked with management system consultants, and the Department of Energy (DOE) to develop an ESH management systems process to compare current LANL ESH management Systems and programs against leading industry standards. The process enabled the Laboratory to gauge its performance in each of the following areas: Planning and Policy Setting; Systems and Procedures; Implementation and Education; and Monitoring and Reporting. The information gathered on ESH management systems enabled LANL to pinpoint and prioritize opportunities for improvement in the provision of ESH services throughout the Laboratory and ultimately overall ESH compliance.

  1. The evaluation of hospital laboratory information management systems based on the standards of the American National Standard Institute.

    PubMed

    Isfahani, Sakineh Saghaeiannejad; Khajouei, Reza; Jahanbakhsh, Maryan; Mirmohamadi, Mahboubeh

    2014-01-01

    Nowadays, modern laboratories are faced with a huge volume of information. One of the goals of the Laboratory Information Management System (LIMS) is to assist in the management of the information generated in the laboratory. This study intends to evaluate the LIMS based on the standards of the American National Standard Institute (ANSI). This research is a descriptive-analytical study, which had been conducted in 2011, on the LIMSs in use, in the teaching and private hospitals in Isfahan. The data collecting instrument was a checklist, which was made by evaluating three groups of information components namely: 'System capabilities', 'work list functions,' and 'reporting' based on LIS8-A. Data were analyzed using the SPSS 20. Data were analyzed using (relative) frequency, percentage. To compare the data the following statistical tests were used: Leven test, t-test, and Analysis of Variance (ANOVA). The results of the study indicated that the LIMS had a low conformity (30%) with LIS8-A (P = 0.001), with no difference between teaching and private hospitals (P = 0.806). The ANOVA revealed that in terms of conformity with the LIS8-A standard, there was a significant difference between the systems produced by different vendors (P = 0.023). According to the results, a Kowsar system with more than %57 conformity in the three groups of information components had a better conformity to the standard, compared to the other systems. This study indicated that none of the LIMSs had a good conformity to the standard. It seems that system providers did not pay sufficient attention to many of the information components required by the standards when designing and developing their systems. It was suggested that standards from certified organizations and institutions be followed in the design and development process of health information systems.

  2. The evaluation of hospital laboratory information management systems based on the standards of the American National Standard Institute

    PubMed Central

    Isfahani, Sakineh Saghaeiannejad; Khajouei, Reza; Jahanbakhsh, Maryan; Mirmohamadi, Mahboubeh

    2014-01-01

    Introduction: Nowadays, modern laboratories are faced with a huge volume of information. One of the goals of the Laboratory Information Management System (LIMS) is to assist in the management of the information generated in the laboratory. This study intends to evaluate the LIMS based on the standards of the American National Standard Institute (ANSI). Materials and Methods: This research is a descriptive–analytical study, which had been conducted in 2011, on the LIMSs in use, in the teaching and private hospitals in Isfahan. The data collecting instrument was a checklist, which was made by evaluating three groups of information components namely: ‘System capabilities’, ‘work list functions,’ and ‘reporting’ based on LIS8-A. Data were analyzed using the SPSS 20. Data were analyzed using (relative) frequency, percentage. To compare the data the following statistical tests were used: Leven test, t-test, and Analysis of Variance (ANOVA). Results: The results of the study indicated that the LIMS had a low conformity (30%) with LIS8-A (P = 0.001), with no difference between teaching and private hospitals (P = 0.806). The ANOVA revealed that in terms of conformity with the LIS8-A standard, there was a significant difference between the systems produced by different vendors (P = 0.023). According to the results, a Kowsar system with more than %57 conformity in the three groups of information components had a better conformity to the standard, compared to the other systems. Conclusions: This study indicated that none of the LIMSs had a good conformity to the standard. It seems that system providers did not pay sufficient attention to many of the information components required by the standards when designing and developing their systems. It was suggested that standards from certified organizations and institutions be followed in the design and development process of health information systems. PMID:25077154

  3. Research Activities at Plasma Research Laboratory at NASA Ames Research Center

    NASA Technical Reports Server (NTRS)

    Sharma, S. P.; Rao, M. V. V. S.; Meyyappan, Meyya

    2000-01-01

    In order to meet NASA's requirements for the rapid development and validation of future generation electronic devices as well as associated materials and processes, enabling technologies are being developed at NASA-Ames Research Center using a multi-discipline approach. The first step is to understand the basic physics of the chemical reactions in the area of plasma reactors and processes. Low pressure glow discharges are indispensable in the fabrication of microelectronic circuits. These plasmas are used to deposit materials and also etch fine features in device fabrication. However, many plasma-based processes suffer from stability and reliability problems leading to a compromise in performance and a potentially increased cost for the semiconductor manufacturing industry. Although a great deal of laboratory-scale research has been performed on many of these processing plasmas, little is known about the gas-phase and surface chemical reactions that are critical in many etch and deposition processes, and how these reactions are influenced by the variation in operating conditions. Such a lack of understanding has hindered the development of process models that can aid in the scaling and improvement of plasma etch and deposition systems. Our present research involves the study of such plasmas. An inductively-coupled plasma (ICP) source in place of the standard upper electrode assembly of the Gaseous Electronics Conference (GEC) radio-frequency (RF) Reference Cell is used to investigate the discharge characteristics. This ICP source generates plasmas with higher electron densities and lower operating pressures than obtainable with the original parallel-plate version of the GEC Cell. This expanded operating regime is more relevant to new generations of industrial plasma systems being used by the microelectronics industry. The research goal is to develop an understanding of the physical phenomena involved in plasma processing and to measure much needed fundamental

  4. Comparison of nonmesonic hypernuclear decay rates computed in laboratory and center-of-mass coordinates

    SciTech Connect

    De Conti, C.; Barbero, C.; Galeão, A. P.; Krmpotić, F.

    2014-11-11

    In this work we compute the one-nucleon-induced nonmesonic hypernuclear decay rates of {sub Λ}{sup 5}He, {sub Λ}{sup 12}C and {sub Λ}{sup 13}C using a formalism based on the independent particle shell model in terms of laboratory coordinates. To ascertain the correctness and precision of the method, these results are compared with those obtained using a formalism in terms of center-of-mass coordinates, which has been previously reported in the literature. The formalism in terms of laboratory coordinates will be useful in the shell-model approach to two-nucleon-induced transitions.

  5. Surveying technologists: a novel method for establishing productivity standards in a clinical haematology laboratory.

    PubMed

    Jatoi, A; Jaromin, R; Grzybek, D; Nguyen, P L

    1997-01-01

    Personnel costs comprise the largest clinical laboratory expense. Yet standards to judge the productivity of personnel have not been established. A survey of the authors' own personnel was conducted to derive productivity standards in the Clinical Hematology Laboratory at the Massachusetts General Hospital, Boston, Massachusetts, USA. Technologists were asked how many white blood cell differentials they could perform in an eight-hour shift. Differential productivity was tracked before and after the survey. Of the respondents, 100 per cent failed to meet their own expectations of productivity. Nine technologists were tracked both before and after the survey was mailed and manifested a significant increase in productivity. These results suggest that technologists are objective in their assessment of their own productivity, that their opinions might be a resource for establishing productivity standards within the laboratory, and that such surveys may serve as motivational tools to augment productivity.

  6. Updated standards and processes for accreditation of echocardiographic laboratories from The European Association of Cardiovascular Imaging.

    PubMed

    Popescu, Bogdan A; Stefanidis, Alexandros; Nihoyannopoulos, Petros; Fox, Kevin F; Ray, Simon; Cardim, Nuno; Rigo, Fausto; Badano, Luigi P; Fraser, Alan G; Pinto, Fausto; Zamorano, Jose Luis; Habib, Gilbert; Maurer, Gerald; Lancellotti, Patrizio; Andrade, Maria Joao; Donal, Erwan; Edvardsen, Thor; Varga, Albert

    2014-07-01

    Standards for echocardiographic laboratories were proposed by the European Association of Echocardiography (now the European Association of Cardiovascular Imaging) 7 years ago in order to raise standards of practice and improve the quality of care. Criteria and requirements were published at that time for transthoracic, transoesophageal, and stress echocardiography. This paper reassesses and updates the quality standards to take account of experience and the technical developments of modern echocardiographic practice. It also discusses quality control, the incentives for laboratories to apply for accreditation, the reaccreditation criteria, and the current status and future prospects of the laboratory accreditation process. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com.

  7. Public health microbiology in Germany: 20 years of national reference centers and consultant laboratories.

    PubMed

    Beermann, Sandra; Allerberger, Franz; Wirtz, Angela; Burger, Reinhard; Hamouda, Osamah

    2015-10-01

    In 1995, in agreement with the German Federal Ministry of Health, the Robert Koch Institute established a public health microbiology system consisting of national reference centers (NRCs) and consultant laboratories (CLs). The goal was to improve the efficiency of infection protection by advising the authorities on possible measures and to supplement infectious disease surveillance by monitoring selected pathogens that have high public health relevance. Currently, there are 19 NRCs and 40 CLs, each appointed for three years. In 2009, an additional system of national networks of NRCs and CLs was set up in order to enhance effectiveness and cooperation within the national reference laboratory system. The aim of these networks was to advance exchange in diagnostic methods and prevention concepts among reference laboratories and to develop geographic coverage of services. In the last two decades, the German public health laboratory reference system coped with all major infectious disease challenges. The European Union and the European Centre for Disease Prevention and Control (ECDC) are considering implementing a European public health microbiology reference laboratory system. The German reference laboratory system should be well prepared to participate actively in this upcoming endeavor.

  8. Multi-laboratory testing of a screening method for world trade center (WTC) collapse dust.

    PubMed

    Rosati, Jacky A; Bern, Amy M; Willis, Robert D; Blanchard, Fredrick T; Conner, Teri L; Kahn, Henry D; Friedman, David

    2008-02-15

    The September 11, 2001 attack on the World Trade Center (WTC) covered a large area of downtown New York City with dust and debris. This paper describes the testing of an analytical method designed to evaluate whether sampled dust contains dust that may have originated from the collapse of the WTC. Using dust samples collected from locations affected and not affected (referred to as 'background' locations) by the collapse, a scanning electron microscopy (SEM) analysis method was developed to screen for three materials that are believed to be present in large quantities in WTC dusts: slag wool, concrete, and gypsum. An inter-laboratory evaluation of the method was implemented by having eight laboratories analyze a number of 'blind' dust samples, consisting of confirmed background dust and confirmed background dust spiked with varying amounts of dust affected by the WTC collapse. The levels of gypsum and concrete in the spiked samples were indistinguishable from the levels in the background samples. Measurements of slag wool in dust demonstrated potential for distinguishing between spiked and background samples in spite of considerable within and between laboratory variability. Slag wool measurements appear to be sufficiently sensitive to distinguish dust spiked with 5% WTC-affected dust from 22 out of 25 background dust samples. Additional development work and inter-laboratory testing of the slag wool component will be necessary to improve the precision and accuracy of the method and reduce inter- and intra-laboratory variability from levels observed in the inter-laboratory evaluation.

  9. Spectroscopy and astronomy: H3+ from the laboratory to the Galactic center.

    PubMed

    Oka, Takeshi

    2011-01-01

    Since the serendipitous discovery of the Fraunhofer spectrum in the Sun in 1814 which initiated spectroscopy and astrophysics, spectroscopy developed hand in hand with astronomy. I discuss my own work on the infrared spectrum of H3+ from its discovery in the laboratory in 1980, in interstellar space in 1996, to recent studies in the Galactic center as an example of astronomical spectroscopy. Its spin-off, the spectroscopy of simple molecular ions, is also briefly discussed.

  10. NASA Glenn Research Center's Fuel Cell Stack, Ancillary and System Test and Development Laboratory

    NASA Technical Reports Server (NTRS)

    Loyselle, Patricia L.; Prokopius, Kevin P.; Becks, Larry A.; Burger, Thomas H.; Dick, Joseph F.; Rodriguez, George; Bremenour, Frank; Long, Zedock

    2011-01-01

    At the NASA Glenn Research Center, a fully operational fuel cell test and evaluation laboratory is available which is capable of evaluating fuel cell components and systems for future NASA missions. Components and subsystems of various types can be operated and monitored under a variety of conditions utilizing different reactants. This fuel cell facility can test the effectiveness of various component and system designs to meet NASA's needs.

  11. [Activities and responsibilities of workers in embryologic and andrologic laboratories in assisted reproduction centers].

    PubMed

    Záková, J; Trávník, P; Malenovská, A; Hűttelová, R

    2013-11-01

    This paper presents the current status and rules for the laboratory staff activities and their competences in the centers of assisted reproduction. The rules were processed by the members of the Association of Reproductive Embryology (ARE) committee under the current legislation. Committee members of the Czech Sterility and Assisted Reproduction Society and Czech Gynecology and Obstetric Society approved these rules as obligatory for assisted reproduction centres in Czech Republic.

  12. CIRCE, the Proposed Coherent Infrared Center at the LawrenceBerkeley National Laboratory

    SciTech Connect

    Byrd, John M.; Martin, Michael M.; Sannibale, Fernando

    2005-07-12

    At the Advanced Light Source (ALS) of the Lawrence Berkeley National Laboratory (LBNL), we are proposing the construction of CIRCE (Coherent InfraRed Center), a ring-based photon source completely optimized for the generation of coherent synchrotron radiation (CSR) in the terahertz frequency range [1]. CIRCE exploits the full complement of the CSR-production mechanisms presently available for obtaining top performance, including a photon flux exceeding by more than nine orders of magnitude that of existing ''conventional'' broadband terahertz sources.

  13. National laboratories` capabilities summaries for the DOE Virtual Center for Multiphase Dynamics (VCMD)

    SciTech Connect

    Joyce, E.L.

    1997-03-01

    The Virtual Center For Multiphase Dynamics (VCMD) integrates and develops the resources of industry, government, academia, and professional societies to enable reliable analysis in multiphase computational fluid dynamics. The primary means of the VCMD focus will be by the creation, support, and validation of a computerized simulation capability for multiphase flow and multiphase flow applications. This paper briefly describes the capabilities of the National Laboratories in this effort.

  14. Standardization in laboratory medicine: Adoption of common reference intervals to the Croatian population

    PubMed Central

    Flegar-Meštrić, Zlata; Perkov, Sonja; Radeljak, Andrea

    2016-01-01

    Considering the fact that the results of laboratory tests provide useful information about the state of health of patients, determination of reference value is considered an intrinsic part in the development of laboratory medicine. There are still huge differences in the analytical methods used as well as in the associated reference intervals which could consequently significantly affect the proper assessment of patient health. In a constant effort to increase the quality of patients’ care, there are numerous international initiatives for standardization and/or harmonization of laboratory diagnostics in order to achieve maximum comparability of laboratory test results and improve patient safety. Through the standardization and harmonization processes of analytical methods the ability to create unique reference intervals is achieved. Such reference intervals could be applied globally in all laboratories using methods traceable to the same reference measuring system and analysing the biological samples from the populations with similar socio-demographic and ethnic characteristics. In this review we outlined the results of the harmonization processes in Croatia in the field of population based reference intervals for clinically relevant blood and serum constituents which are in accordance with ongoing activity for worldwide standardization and harmonization based on traceability in laboratory medicine. PMID:27019800

  15. Utilization of an automated multimeter calibration system by the Rocky Flats Standards Laboratory

    SciTech Connect

    Wickoff, B.; Stant, R.S.; Brown, G.R. Jr.

    1982-09-10

    The Physical Metrology Laboratory (PML) of the Rocky Flats (RF) Standards Laboratory, like many other standards laboratories, was inundated during the past decade with the vast variety of new digital multimeters. These multimeters were produced by several companies, and required accurate calibrations and certification to support the requirements at the Rocky Flats Plant. The need to automate the calibration and certification process accurately was vividly indicated by a time study of performing the process manually, for both the digital and the analog multimeters, in the PML Reference Standards Laboratory. By using an automated calibration system, approximately 90% of these calibrations could be completed in the Physical Metrology Support Laboratories with a reduction of 50% or more in hours required for the calibrations. With these specific requirements and other specifications deemed necessary, the automated calibration systems for digital and analog multimeters were purchased. Two Fluke 5101B Calibrators with Fluke 5220A Transconductance Amplifiers and two printers were procured for use by the Physical Metrology Support Laboratories. There operation and performance are described.

  16. A guide for integration of proteomic data standards into laboratory workflows.

    PubMed

    Medina-Aunon, J Alberto; Krishna, Ritesh; Ghali, Fawaz; Albar, Juan P; Jones, Andrew J

    2013-02-01

    The development of the HUPO-Proteomics Standards Initiative standard data formats and Minimum Information About a Proteomics Experiment guidelines facilitate coordination within the scientific community. The data standards provide a framework to exchange and share data regardless of the source instrument or software. Nevertheless there remains a view that Proteomics Standards Initiative standards are challenging to use and integrate into routine laboratory pipelines. In this article, we review the tools available for integrating the different data standards and building compliant software. These tools are focused on a range of different data types and support different scenarios, intended for software developers or end users, allowing the standards to be used in a straightforward manner. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Rapid Ascent From Zero Quality to International Organization for Standardization Accreditation: A Case Study of Hai Duong Preventive Medicine Center in Vietnam, 2012-2013.

    PubMed

    Duong, Cuong Ngoc; Bond, Kyle B; Carvalho, Humberto; Thi Thu, Hien Bui; Nguyen, Thuong; Rush, Thomas

    2017-04-01

    In 2012, the Vietnam Ministry of Health sought to improve the quality of health laboratories by introducing international quality standards. Strengthening Laboratory Management Toward Accreditation (SLMTA), a year-long, structured, quality improvement curriculum (including projects and mentorship) was piloted in 12 laboratories. Progress was measured using a standardized audit tool (Stepwise Laboratory Quality Improvement Process Towards Accreditation). All 12 pilot laboratories (a mix of hospital and public health) demonstrated improvement; median scores rose from 44% to 78% compliance. The public health laboratory in Hai Duong Province entered the program with the lowest score of the group (28%) yet concluded with the highest score (86%). Five months after the completion of the program, without any additional external support, they were accredited. Laboratory management/staff describe factors key to their success: support from the facility senior management, how-to guidance provided by SLMTA, support from the site mentor, and strong commitment of laboratory staff. Hai Duong preventive medical center is one of only a handful of laboratories to reach accreditation after participation in SLMTA and the only laboratory to do so without additional support. Due to the success seen in Hai Duong and other pilot laboratories, Vietnam has expanded the use of SLMTA.

  18. NASA Lewis Research Center replaces the NACA Lewis Flight Propulsion Laboratory

    NASA Image and Video Library

    1958-10-21

    A security guard examines the new sign near the entrance to the Lewis Research Center one day after the National Aeronautics and Space Administration (NASA) was officially established. NASA came into being on October 1, 1958, and the National Advisory Committee for Aeronautics (NACA) Lewis Flight Propulsion Laboratory became the NASA Lewis Research Center. Lewis underwent a major reorganization and began concentrating its efforts almost exclusively on the space program. NACA Lewis researchers had been advocating further space research for years. As early as 1955, Lewis management urged the NACA expand its rocket engine research as a logical extension of its aircraft engine work. Lewis management claimed that space exploration was imperative for the nation’s survival during the Cold War. They called for an annual 25-percent increase in the NACA’s staff, a new space laboratory, a launching center, communications center, and other facilities. They were basically outlining what would be needed for the new space agency. During NASA’s first two years of existence, Lewis refocused its efforts almost completely on the space program. Less than 10 percent of the annual budget was dedicated to aeronautics. In the aftermath that followed President Kennedy’s April 1961 “Urgent Needs” address to Congress, NASA was given a seemingly unlimited budget. The Agency reorganized and began swelling its ranks through a massive recruiting effort to accomplish the accelerated lunar landing mission. Lewis personnel increased from approximately 2,700 in 1961 to over 4,800 in 1966.

  19. Learning Resource Center Standards for Vocational Programs. Monograph Series No. 4.

    ERIC Educational Resources Information Center

    Bucher, Mary Ann; And Others

    Standards are offered to administrators and practitioners as a conceptual framework for successful vocational learning resource center programs, and a program evaluation instrument is presented to aid vocational education structures in identifying their strengths, weaknesses, and possible plans for improvement. The standards cover seven areas:…

  20. Ebola Virus Diagnostics: The US Centers for Disease Control and Prevention Laboratory in Sierra Leone, August 2014 to March 2015.

    PubMed

    Flint, Mike; Goodman, Christin H; Bearden, Scott; Blau, Dianna M; Amman, Brian R; Basile, Alison J; Belser, Jessica A; Bergeron, Éric; Bowen, Michael D; Brault, Aaron C; Campbell, Shelley; Chakrabarti, Ayan K; Dodd, Kimberly A; Erickson, Bobbie R; Freeman, Molly M; Gibbons, Aridth; Guerrero, Lisa W; Klena, John D; Lash, R Ryan; Lo, Michael K; McMullan, Laura K; Momoh, Gbetuwa; Massally, James L; Goba, Augustine; Paddock, Christopher D; Priestley, Rachael A; Pyle, Meredith; Rayfield, Mark; Russell, Brandy J; Salzer, Johanna S; Sanchez, Angela J; Schuh, Amy J; Sealy, Tara K; Steinau, Martin; Stoddard, Robyn A; Taboy, Céline; Turnsek, Maryann; Wang, David; Zemtsova, Galina E; Zivcec, Marko; Spiropoulou, Christina F; Ströher, Ute; Towner, Jonathan S; Nichol, Stuart T; Bird, Brian H

    2015-10-01

    In August 2014, the Viral Special Pathogens Branch of the US Centers for Disease Control and Prevention established a field laboratory in Sierra Leone in response to the ongoing Ebola virus outbreak. Through March 2015, this laboratory tested >12 000 specimens from throughout Sierra Leone. We describe the organization and procedures of the laboratory located in Bo, Sierra Leone.

  1. ISO/IEC 17025 laboratory accreditation of NRC Acoustical Standards Program

    NASA Astrophysics Data System (ADS)

    Wong, George S. K.; Wu, Lixue; Hanes, Peter; Ohm, Won-Suk

    2004-05-01

    Experience gained during the external accreditation of the Acoustical Standards Program at the Institute for National Measurement Standards of the National Research Council is discussed. Some highlights include the preparation of documents for calibration procedures, control documents with attention to reducing future paper work and the need to maintain documentation or paper trails to satisfy the external assessors. General recommendations will be given for laboratories that are contemplating an external audit in accordance to the requirements of ISO/IEC 17025.

  2. Space and Missile Systems Center Standard: Test Requirements for Ground Systems

    DTIC Science & Technology

    2013-09-30

    changes, additions, deletions, etc.) and any pertinent data that may be of use in improving this standard should be forwarded to the following addressee... using the Standardization Document Improvement Proposal appearing at the end of this document or by letter: Division Chief, SMC/ENE SPACE AND...MISSILE SYSTEMS CENTER Air Force Space Command 483 N. Aviation Blvd. El Segundo, CA 90245 4. This standard has been approved for use on all Space and

  3. 42 CFR 493.1773 - Standard: Basic inspection requirements for all laboratories issued a CLIA certificate and CLIA...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... AND CERTIFICATION LABORATORY REQUIREMENTS Inspection § 493.1773 Standard: Basic inspection... 42 Public Health 5 2010-10-01 2010-10-01 false Standard: Basic inspection requirements for all laboratories issued a CLIA certificate and CLIA-exempt laboratories. 493.1773 Section 493.1773 Public Health...

  4. DOE standard: The Department of Energy Laboratory Accreditation Program for radiobioassay

    SciTech Connect

    1998-12-01

    This technical standard describes the US Department of Energy Laboratory Accreditation Program (DOELAP) for Radiobioassay, for use by the US Department of Energy (DOE) and DOE Contractor radiobioassay programs. This standard is intended to be used in conjunction with the general administrative technical standard that describes the overall DOELAP accreditation process--DOE-STD-1111-98, Department of Energy Laboratory Accreditation Program Administration. This technical standard pertains to radiobioassay service laboratories that provide either direct or indirect (in vivo or in vitro) radiobioassay measurements in support of internal dosimetry programs at DOE facilities or for DOE and DOE contractors. Similar technical standards have been developed for other DOELAP dosimetry programs. This program consists of providing an accreditation to DOE radiobioassay programs based on successful completion of a performance-testing process and an on-site evaluation by technical experts. This standard describes the technical requirements and processes specific to the DOELAP Radiobioassay Accreditation Program as required by 10 CFR 835 and as specified generically in DOE-STD-1111-98.

  5. College of American Pathologists' laboratory standards for next-generation sequencing clinical tests.

    PubMed

    Aziz, Nazneen; Zhao, Qin; Bry, Lynn; Driscoll, Denise K; Funke, Birgit; Gibson, Jane S; Grody, Wayne W; Hegde, Madhuri R; Hoeltge, Gerald A; Leonard, Debra G B; Merker, Jason D; Nagarajan, Rakesh; Palicki, Linda A; Robetorye, Ryan S; Schrijver, Iris; Weck, Karen E; Voelkerding, Karl V

    2015-04-01

    The higher throughput and lower per-base cost of next-generation sequencing (NGS) as compared to Sanger sequencing has led to its rapid adoption in clinical testing. The number of laboratories offering NGS-based tests has also grown considerably in the past few years, despite the fact that specific Clinical Laboratory Improvement Amendments of 1988/College of American Pathologists (CAP) laboratory standards had not yet been developed to regulate this technology. To develop a checklist for clinical testing using NGS technology that sets standards for the analytic wet bench process and for bioinformatics or "dry bench" analyses. As NGS-based clinical tests are new to diagnostic testing and are of much greater complexity than traditional Sanger sequencing-based tests, there is an urgent need to develop new regulatory standards for laboratories offering these tests. To develop the necessary regulatory framework for NGS and to facilitate appropriate adoption of this technology for clinical testing, CAP formed a committee in 2011, the NGS Work Group, to deliberate upon the contents to be included in the checklist. Results . -A total of 18 laboratory accreditation checklist requirements for the analytic wet bench process and bioinformatics analysis processes have been included within CAP's molecular pathology checklist (MOL). This report describes the important issues considered by the CAP committee during the development of the new checklist requirements, which address documentation, validation, quality assurance, confirmatory testing, exception logs, monitoring of upgrades, variant interpretation and reporting, incidental findings, data storage, version traceability, and data transfer confidentiality.

  6. Preparation, control, and use of standard operating procedures in a space simulation laboratory

    NASA Technical Reports Server (NTRS)

    Parish, R. P., Jr.

    1975-01-01

    The degree of success in the operation of a space simulation laboratory is a direct function of the role of its standard operating procedures. Their proper use in a thermal vacuum test effects a wellrun test program. Preparation and procedure control are discussed.

  7. Importance of the Primary Radioactivity Standard Laboratory and Implementation of its Quality Management

    NASA Astrophysics Data System (ADS)

    Sahagia, Maria; Razdolescu, Anamaria Cristina; Luca, Aurelian; Ivan, Constantin

    2007-04-01

    The paper presents some specific aspects of the implementation of the quality management in the Radionuclide Metrology Laboratory, from IFIN-HH, the owner of the primary Romanian standard in radioactivity. The description of the accreditation, according to the EN ISO/IEC 17025:2005, is presented.

  8. Preparation, control, and use of standard operating procedures in a space simulation laboratory

    NASA Technical Reports Server (NTRS)

    Parish, R. P., Jr.

    1975-01-01

    The degree of success in the operation of a space simulation laboratory is a direct function of the role of its standard operating procedures. Their proper use in a thermal vacuum test effects a wellrun test program. Preparation and procedure control are discussed.

  9. NATIONAL ENVIRONMENTAL LABORATORY ACCREDITATION CONFERENCE: CONSTITUTION, BYLAWS AND STANDARDS; APPROVED JUNE 2000

    EPA Science Inventory

    As Director of the Environmental Protection Agency's National Environmental
    Laboratory Accreditation Program (NELAP), I offer my sincere appreciation to the many individuals who worked on the 2000 revision of the NELAC standards. I would like to give special recognition to th...

  10. NATIONAL ENVIRONMENTAL LABORATORY ACCREDITATION CONFERENCE: CONSTITUTION, BYLAWS AND STANDARDS; APPROVED JUNE 2000

    EPA Science Inventory

    As Director of the Environmental Protection Agency's National Environmental
    Laboratory Accreditation Program (NELAP), I offer my sincere appreciation to the many individuals who worked on the 2000 revision of the NELAC standards. I would like to give special recognition to th...

  11. Verification and standardization of blood cell counters for routine clinical laboratory tests.

    PubMed

    Verbrugge, Sue Ellen; Huisman, Albert

    2015-03-01

    The use of automated blood cell counters (automated hematology analyzers) for diagnostic purposes is inextricably linked to clinical laboratories. However, the need for uniformity among the various methods and parameters is increasing and standardization of the automated analyzers is therefore crucial. Standardization not only involves procedures based on reference methods but it also involves validation, verification, quality assurance, and quality control, and it includes the involvement of several participants. This article discusses the expert guidelines and provides an overview of issues involved in complete blood count parameter reference methods and standardization of reporting units. Copyright © 2015 Elsevier Inc. All rights reserved.

  12. 75 FR 9229 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-01

    ...-7299, 501-202-2783. (Formerly: Forensic Toxicology Laboratory Baptist Medical Center) Clinical... Affairs Medical Center, Forensic Toxicology Laboratory, 1 Veterans Drive, Minneapolis, MN 55417, 612-725... Testing Service, Inc., 5426 NW. 79th Ave., Miami, FL 33166, 305-593-2260. U.S. Army Forensic Toxicology...

  13. Update on current concepts and meanings in laboratory medicine --Standardization, traceability and harmonization.

    PubMed

    Greenberg, Neil

    2014-05-15

    An increasingly important quality objective in laboratory medicine is ensuring the equivalence of test results among different measurement procedures, different laboratories and health care systems, over time. In recent years, interest in sharing a single patient's clinical laboratory data, regardless of where the measurements are performed, has moved out of the domain of the scientific community and spilled over into the domain of regulators, lawmakers and the general population in many parts of the world. For all parties involved in the dialog, establishing and maintaining a clear understanding of the essential concepts that are vital to achieving global equivalence among clinical laboratory measurements have therefore become a priority. Concepts that are critical to this discussion include standardization, traceability and harmonization. This report provides an updated discussion and practical definitions for these terms and others that are linked to metrological principles.

  14. Laboratory robotics -- An automated tool for preparing ion chromatography calibration standards

    SciTech Connect

    Chadwick, J.L.

    1995-04-01

    This paper describes the use of a laboratory robot as an automated tool for preparing multi-level calibration standards for On-Line Ion Chromatography (IC) Systems. The robot is designed for preparation of up to six levels of standards, with each level containing up to eleven ionic species in aqueous solution. The robot is required to add the standards` constituents as both a liquid and solid additions and to keep a record of exactly what goes into making up every standard. Utilizing a laboratory robot to prepare calibration standards provides significant benefits to the testing environment. These benefits include: accurate and precise calibration standards in individually capped containers with preparation traceability; automated and unattended multi-specie preparation for both anion and cation analytical channels; the ability to free up a test operator from a repetitive routine and re-apply those efforts to test operations; The robot uses a single channel IC to analyze each prepared standard for specie content and concentration. Those results are later used as a measure of quality control. System requirements and configurations, robotic operations, manpower requirements, analytical verification, accuracy and precision of prepared solutions, and robotic downtime are discussed in detail.

  15. [Implementation of the technical requirements of the UNE-EN-ISO 15189 quality standard in a mycobacterial laboratory].

    PubMed

    Guna Serrano, M del Remedio; Ocete Mochón, M Dolores; Lahiguera, M José; Bresó, M Carmen; Gimeno Cardona, Concepción

    2013-02-01

    The UNE-EN-ISO 15189:2007 standard defines the requirements for quality and competence that must be met by medical laboratories. These laboratories should use this international standard to develop their own quality management systems and to evaluate their own competencies; in turn, this standard will be used by accreditation bodies to confirm or recognize the laboratories' competence. In clinical microbiology laboratories, application of the standard implies the implementation of the technical and specific management requirements that must be met to achieve optimal quality when carrying out microbiological tests. In Spain, accreditation is granted by the Spanish Accreditation Body (Entidad Nacional de Acreditación). This review aims to discuss the practical application of the standard's technical requirements in mycobacterial laboratory. Firstly, we define the scope of accreditation. Secondly, we specify how the items of the standard on personnel management, control of equipment, environmental facilities, method validation, internal controls and customer satisfaction surveys were developed and implemented in our laboratory.

  16. Development Of International Data Standards For The COSMOS/PEER-LL Virtual Data Center

    NASA Astrophysics Data System (ADS)

    Swift, J. N.

    2005-12-01

    The COSMOS -PEER Lifelines Project 2L02 completed a Pilot Geotechnical Virtual Data Center (GVDC) system capable of both archiving geotechnical data and of disseminating data from multiple linked geotechnical databases. The Pilot GVDC system links geotechnical databases of four organizations: the California Geological Survey, Caltrans, PG&E, and the U. S. Geological Survey The System was presented and reviewed in the COSMOS-PEER Lifelines workshop on June 21 - 23, 2004, which was co-sponsored by the Federal Highway Administration (FHWA) and included participation by the United Kingdom Highways Agency (UKHA) , the Association of Geotechnical and Geoenvironmental Specialists in the United Kingdom (AGS), the United States Army Corp of Engineers (USACOE), Caltrans, United States Geological Survey (USGS), California Geological Survey (CGS), a number of state Departments of Transportation (DOTs), county building code officials, and representatives of academic institutions and private sector geotechnical companies. As of February 2005 COSMOS-PEER Lifelines Project 2L03 is currently funded to accomplish the following tasks: 1) expand the Pilot GVDC Geotechnical Data Dictionary and XML Schema to include data definitions and structures to describe in-situ measurements such as shear wave velocity profiles, and additional laboratory geotechnical test types; 2) participate in an international cooperative working group developing a single geotechnical data exchange standard that has broad international acceptance; and 3) upgrade the GVDC system to support corresponding exchange standard data dictionary and schema improvements. The new geophysical data structures being developed will include PS-logs, downhole geophysical logs, cross-hole velocity data, and velocity profiles derived using surface waves. A COSMOS-PEER Lifelines Geophysical Data Dictionary Working Committee constituted of experts in the development of data dictionary standards and experts in the specific data to be

  17. Expansion of the Idaho National Engineering Laboratory Research Center: Environmental assessment

    SciTech Connect

    Not Available

    1994-03-01

    The US Department of Energy (DOE) proposes to expand and upgrade facilities at the Idaho National Engineering Laboratory (INEL) Research Center (IRC) by constructing a research laboratory addition on the northeast corner of existing laboratory building; upgrading the fume hood system in the existing laboratory building; and constructing a hazardous waste handling facility and a chemical storage building. The DOE also proposes to expand the capabilities of biotechnology research programs by increasing use of radiolabeled compounds to levels in excess of current facility limits for three radionuclides (carbon-14, sulfur-35, and phosphorus-32). This Environmental assessment identifies the need for the new facilities, describes the proposed projects and environmental setting, and evaluates the potential environmental effects. Impacts associated with current operation are discussed and established as a baseline. Impacts associated with the proposed action and cumulative impacts are described against this background. Alternatives to the proposed action (No action; Locating proposed facilities at a different site) are discussed and a list of applicable regulations is provided. The no action alternative is continuation of existing operations at existing levels as described in Section 4 of this EA. Proposed facilities could be constructed at a different location, but these facilities would not be useful or practical since they are needed to provide a support function for IRC operations. Further, the potential environmental impacts would not be reduced if a different site was selected.

  18. 75 FR 62842 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-13

    ..., 11401 I-30, Little Rock, AR 72209-7056, 501-202-2783, (Formerly: Forensic Toxicology Laboratory Baptist... Affairs Medical Center, Forensic Toxicology Laboratory, 1 Veterans Drive, Minneapolis, MN 55417, 612-725...., Miami, FL 33166, 305-593-2260. U.S. Army Forensic Toxicology Drug Testing Laboratory, 2490 Wilson St...

  19. 75 FR 32950 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-10

    ...-Toxicology Laboratory, 9601 I-630, Exit 7, Little Rock, AR 72205-7299. 501-202-2783. (Formerly: Forensic...-5295. Minneapolis Veterans Affairs Medical Center, Forensic Toxicology Laboratory, 1 Veterans Drive.... U.S. Army Forensic Toxicology Drug Testing Laboratory, 2490 Wilson St., Fort George G. Meade, MD...

  20. Activities of the Japanese space weather forecast center at Communications Research Laboratory.

    PubMed

    Watari, Shinichi; Tomita, Fumihiko

    2002-12-01

    The International Space Environment Service (ISES) is an international organization for space weather forecasts and belongs to the International Union of Radio Science (URSI). There are eleven ISES forecast centers in the world, and Communications Research Laboratory (CRL) runs the Japanese one. We make forecasts on the space environment and deliver them over the phones and through the Internet. Our forecasts could be useful for human activities in space. Currently solar activity is near maximum phase of the solar cycle 23. We report the several large disturbances of space environment occurred in 2001, during which low-latitude auroras were observed several times in Japan.

  1. Synergistic control center development utilizing commercial technology and industry standards. [NASA space programs

    NASA Technical Reports Server (NTRS)

    Anderson, Brian L.

    1993-01-01

    The development of the Control Center Complex (CCC), a synergistic control center supporting both the Space Station Freedom and the Space Shuttle Program, is described. To provide maximum growth and flexibility, the CCC uses commercial off-the-shelf technology and industry standards. The discussion covers the development philosophy, CCC architecture, data distribution, the software platform concept, workstation platform, commercial tools for the CCC, and benefits of synergy.

  2. Groove depth measurements on roughness reference standards of the Croatian National Laboratory for Length (LFSB)

    NASA Astrophysics Data System (ADS)

    Baršić, Gorana; Mahović, Sanjin; Bartolo Picotto, Gian; Amer, Mohamed A.; Runje, Biserka

    2011-09-01

    In the Laboratory for Precise Measurements of Length, LFSB, which is now the Croatian National Laboratory for Length, unique roughness reference standards were developed in the year 1986. Because of the world-class quality of those standards and their measuring features, the same were sold in several European countries, and today they, among others, are used as roughness reference standards in Italy, Slovenia and Croatia. However, especially in the last decade, there was significant progress in the field of nanotechnology that led to the development of new measuring equipment. The above-mentioned standards due to their size, production technology and measuring features cannot fully meet metrological requirements in the field of nanometrology, i.e. they are not compatible with scanning probe microscopes. Therefore, it was decided to search for possible limitations in the procedure of groove depth measurements on the LFSB standards. In order to include as many measuring devices as possible, i.e. measurement methods, in this research, in 2008 the LFSB launched EURAMET Project 1012 'Limitations of methods for measuring the depth of the groove' in collaboration with national metrology institutes of Italy and Egypt. In this paper the results of measurements performed within the project are presented, and based on the obtained results, the advantages and limitations of the LFSB standards have been discussed, with recommendations for their improvement.

  3. Paving the way for a gold standard of care for infertility treatment: improving outcomes through standardization of laboratory procedures.

    PubMed

    Schoolcraft, William; Meseguer, Marcos

    2017-07-14

    Infertility affects over 70 million couples globally. Access to, and interest in, assisted reproductive technologies is growing worldwide, with more couples seeking medical intervention to conceive, in particular by IVF. Despite numerous advances in IVF techniques since its first success in 1978, almost half of the patients treated remain childless. The multifactorial nature of IVF treatment means that success is dependent on many variables. Therefore, it is important to examine how each variable can be optimized to achieve the best possible outcomes for patients. The current approach to IVF is fragmented, with various protocols in use. A systematic approach to establishing optimum best practices may improve IVF success and live birth rates. Our vision of the future is that technological advancements in the laboratory setting are standardized and universally adopted to enable a gold standard of care. Implementation of best practices for laboratory procedures will enable clinicians to generate high-quality gametes, and to produce and identify gametes and embryos of maximum viability and implantation potential, which should contribute to improving take-home healthy baby rates. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

  4. Current practices and challenges in the standardization and harmonization of clinical laboratory tests123

    PubMed Central

    Vesper, Hubert W; Myers, Gary L; Miller, W Greg

    2016-01-01

    Effective patient care, clinical research, and public health efforts require comparability of laboratory results independent of time, place, and measurement procedure. Comparability is achieved by establishing metrological traceability, which ensures that measurement procedures measure the same quantity and that the calibration of measurement procedures is traceable to a common reference system consisting of reference methods and materials. Whereas standardization ensures traceability to the International System of Units, harmonization ensures traceability to a reference system agreed on by convention. This article provides an overview of standardization and harmonization with an emphasis on commutability as an important variable that affects testing accuracy. Commutability of reference materials is required to ensure that traceability is established appropriately and that laboratory results are comparable. The use of noncommutable reference materials leads to inaccurate results. Whereas procedures and protocols for standardizing measurements are established and have been successfully applied in efforts such as the Hormones Standardization Program of the CDC, harmonization activities require new, more complex procedures and approaches. The American Association for Clinical Chemistry, together with its domestic and international partners, formed the International Consortium for Harmonization of Clinical Laboratory Results to coordinate harmonization efforts. Reference systems, as well as procedures and protocols to establish traceability of clinical laboratory tests, have been established and continue to be developed by national and international groups and organizations. Serum tests of thyroid function, including those for the thyroid hormones thyroxine and triiodothyronine, are among the clinical procedures for which standardization efforts are well under way. Approaches to the harmonization of measurement procedures for serum concentrations of thyroid

  5. Current practices and challenges in the standardization and harmonization of clinical laboratory tests.

    PubMed

    Vesper, Hubert W; Myers, Gary L; Miller, W Greg

    2016-09-01

    Effective patient care, clinical research, and public health efforts require comparability of laboratory results independent of time, place, and measurement procedure. Comparability is achieved by establishing metrological traceability, which ensures that measurement procedures measure the same quantity and that the calibration of measurement procedures is traceable to a common reference system consisting of reference methods and materials. Whereas standardization ensures traceability to the International System of Units, harmonization ensures traceability to a reference system agreed on by convention. This article provides an overview of standardization and harmonization with an emphasis on commutability as an important variable that affects testing accuracy. Commutability of reference materials is required to ensure that traceability is established appropriately and that laboratory results are comparable. The use of noncommutable reference materials leads to inaccurate results. Whereas procedures and protocols for standardizing measurements are established and have been successfully applied in efforts such as the Hormones Standardization Program of the CDC, harmonization activities require new, more complex procedures and approaches. The American Association for Clinical Chemistry, together with its domestic and international partners, formed the International Consortium for Harmonization of Clinical Laboratory Results to coordinate harmonization efforts. Reference systems, as well as procedures and protocols to establish traceability of clinical laboratory tests, have been established and continue to be developed by national and international groups and organizations. Serum tests of thyroid function, including those for the thyroid hormones thyroxine and triiodothyronine, are among the clinical procedures for which standardization efforts are well under way. Approaches to the harmonization of measurement procedures for serum concentrations of thyroid

  6. A pharmacist visit improves diabetes standards in a patient-centered medical home (PCMH).

    PubMed

    Edwards, Heather D; Webb, Ryan D; Scheid, Dewey C; Britton, Mark L; Armor, Becky L

    2012-01-01

    Many patients with diabetes do not receive recommended standards of care. Diabetes patients were seen by a pharmacist in a diabetes assessment service (DAS) 1 week prior to a physician appointment to complete diabetes standards. Completion rates of American Diabetes Association (ADA) standards were compared between patients of 5 physicians offered the DAS intervention and a concurrent cohort of randomly selected patients of nonparticipating physicians. A total of 94 patients were seen by DAS; 210 patients comprised the controls. DAS patients had a significantly higher proportion of each standard completed (glycosylated hemoglobin, lipids, foot exam, eye referral, pneumococcal and influenza vaccination, and urine microalbumin) compared with the control group (P < .001). An average of 3.3 ± 1.8 diabetes standards per patient were completed. A planned visit with a pharmacist prior to a physician appointment, with the goal of completing ADA standards of care, was feasible and effective in this university-based family medicine center.

  7. Comparison of laboratories directors' and assessors' opinions on challenges and solutions of standardization in Iran: a qualitative study.

    PubMed

    Ravaghi, Hamid; Abolhassani, Nazanin

    2015-01-26

    The quality medical laboratory services play a vital role in healthcare systems. Iran has set national standards based on the international standard ISO15189. These standards came into force in September 2007. Given the important role of both laboratories professional and assessors in the standardization, this study aims to compare and analyze medical laboratory directors' and assessors' opinions about this process, its challenges and relevant solutions. This qualitative study was conducted on two populations in 2013. The first survey population consisted of 150 assessors. The second group consisted of directors working in medical laboratory settings. From all universities of medical sciences, 258 medical laboratories were randomly selected. Data were gathered using two open-ended questionnaires and analyzed using the thematic analysis. Challenges and relevant solutions regarding the standardization and standards, the assessment process and assessor, laboratories, external entities and contextual factors across laboratories directors and assessors were derived and compared. Both groups had a positive attitude towards the standardization process. However, they expressed some concerns regarding the process and accordingly proposed solutions to overcome the challenges. This study provides insights into the challenges and solutions of the standardization from two professional groups' viewpoint. These two factors are closely related and should be considered when implementing standards since a positive perception of them increases the likelihood of successful standardization. Similarities and divergences regarding challenges and solutions of the standardization, in turn, can provide insights into how this process can be improved and deserve policy makers' attention to continue the progress.

  8. Comparison of Laboratories Directors’ and Assessors’ Opinions on Challenges and Solutions of Standardization in Iran: A Qualitative Study

    PubMed Central

    Ravaghi, Hamid; Abolhassani, Nazanin

    2015-01-01

    Objective: The quality medical laboratory services play a vital role in healthcare systems. Iran has set national standards based on the international standard ISO15189. These standards came into force in September 2007. Given the important role of both laboratories professional and assessors in the standardization, this study aims to compare and analyze medical laboratory directors’ and assessors’ opinions about this process, its challenges and relevant solutions. Methods: This qualitative study was conducted on two populations in 2013. The first survey population consisted of 150 assessors. The second group consisted of directors working in medical laboratory settings. From all universities of medical sciences, 258 medical laboratories were randomly selected. Data were gathered using two open-ended questionnaires and analyzed using the thematic analysis. Results: Challenges and relevant solutions regarding the standardization and standards, the assessment process and assessor, laboratories, external entities and contextual factors across laboratories directors and assessors were derived and compared. Both groups had a positive attitude towards the standardization process. However, they expressed some concerns regarding the process and accordingly proposed solutions to overcome the challenges. Conclusion: This study provides insights into the challenges and solutions of the standardization from two professional groups’ viewpoint. These two factors are closely related and should be considered when implementing standards since a positive perception of them increases the likelihood of successful standardization. Similarities and divergences regarding challenges and solutions of the standardization, in turn, can provide insights into how this process can be improved and deserve policy makers’ attention to continue the progress. PMID:25946940

  9. The Picatinny Technology Transfer Innovation Center: A business incubator concept adapted to federal laboratory technology transfer

    SciTech Connect

    Wittig, T.; Greenfield, J.

    1996-10-01

    In recent years, the US defense industrial base spawned the aerospace industry, among other successes, and served as the nation`s technology seed bed. However, as the defense industrial base shrinks and public and private resources become scarcer, the merging of the commercial and defense communities becomes necessary to maintain national technological competencies. Cooperative efforts such as technology transfer provide an attractive, cost-effective, well-leveraged alternative to independently funded research and development (R and D). The sharing of knowledge, resources, and innovation among defense contractors and other public sector firms, academia, and other organizations has become exceedingly attractive. Recent legislation involving technology transfer provides for the sharing of federal laboratory resources with the private sector. The Army Research, Development and Engineering Center (ARDEC), Picatinny Arsenal, NJ, a designer of weapons systems, is one of the nation`s major laboratories with this requirement. To achieve its important technology transfer mission, ARDEC reviewed its capabilities, resources, intellectual property, and products with commercial potential. The purpose of the review was to develop a viable plan for effecting a technology transfer cultural change within the ARDEC, Picatinny Arsenal and with the private sector. This report highlights the issues identified, discussed, and resolved prior to the transformation of a temporarily vacant federal building on the Picatinny installation into a business incubator. ARDEC`s discussions and rationale for the decisions and actions that led to the implementation of the Picatinny Technology Transfer Innovation Center are discussed.

  10. Termite-Susceptible Species of Wood for Inclusion as a Reference in Indonesian Standardized Laboratory Testing.

    PubMed

    Arinana; Tsunoda, Kunio; Herliyana, Elis N; Hadi, Yusuf S

    2012-03-28

    Standardized laboratory testing of wood and wood-based products against subterranean termites in Indonesia (SNI 01.7207-2006) (SNI) has no requirement for the inclusion of a comparative reference species of wood (reference control). This is considered a weakness of the Indonesian standard. Consequently, a study was undertaken to identify a suitable Indonesian species of community wood that could be used as a reference control. Four candidate species of community woods: Acacia mangium, Hevea brasiliensis, Paraserianthes falcataria and Pinus merkusii were selected for testing their susceptibility to feeding by Coptotermes formosanus. Two testing methods (SNI and the Japanese standard method JIS K 1571-2004) were used to compare the susceptibility of each species of wood. Included in the study was Cryptomeria japonica, the reference control specified in the Japanese standard. The results of the study indicated that P. merkusii is a suitable reference species of wood for inclusion in laboratory tests against subterranean termites, conducted in accordance with the Indonesian standard (SNI 01.7207-2006).

  11. Food intake in laboratory rats provided standard and fenbendazole-supplemented diets.

    PubMed

    Vento, Peter J; Swartz, Megan E; Martin, Lisa Be; Daniels, Derek

    2008-11-01

    The benzimidazole anthelmintic fenbendazole (FBZ) is a common and effective treatment for pinworm infestation in laboratory animal colonies. Although many investigators have examined the potential for deleterious biologic effects of FBZ, more subtle aspects of the treatment remain untested. Accordingly, we evaluated differences in food intake when healthy male Sprague-Dawley rats were provided a standard nonmedicated laboratory rodent chow or the same chow supplemented with FBZ. We also tested for a preference for either food type when subjects were provided a choice of the 2 diets. Data from these experiments showed no differences in food intake or body weight when rats were maintained on either standard or FBZ-supplemented chow. When the rats were given access to both the standard and FBZ-supplemented diets, they showed a clear preference for the standard diet. The preference for the standard diet indicates that the rats can discriminate between the 2 foods and may avoid the FBZ-supplemented chow when possible. Investigators conducting experiments during treatment with FBZ in which differences in food preference are relevant should be aware of these data and plan their studies accordingly.

  12. A laboratory comparison of individual Targis/Vectris posts with standard fiberglass posts.

    PubMed

    Corsalini, Massimo; Genovese, Katia; Lamberti, Luciano; Pappalettere, Carmine; Carella, Mauro; Carossa, Stefano

    2007-01-01

    This article presents an in vitro analysis of a specific occlusal loading test on endodontically treated teeth restored with 2 different composite post materials. Individual, customized posts (IFPs) were compared to standard fiberglass posts (SFPs). The selected IFPs (standard cylindric Targis/Vectris posts) were compared to SFPs (Conic 6% Post, Ghimas). The posts were first subjected to a 3-point bending test to compare their flexural elastic properties. They were then used to restore 22 endodontically treated artificial maxillary central incisors and subjected to a specific occlusal loading simulation test. The loading test showed that IFP restorations performed better than SFP restorations. A clinical evaluation of this laboratory observation is suggested.

  13. An Australian secondary standard dosimetry laboratory participation in IAEA postal dose audits.

    PubMed

    Davies, J B; Izewska, J; Meriaty, H; Baldock, C

    2013-03-01

    For over 30 years, the International Atomic Energy Agency (IAEA) and the World Health Organization (WHO) have jointly monitored activities of secondary standard dosimetry laboratories (SSDLs) through postal dose audits with the aim of achieving consistency in dosimetry throughout the world. The Australian Nuclear Science and Technology Organisation (ANSTO) maintains an SSDL and is a member of the IAEA/WHO SSDL Network. Postal dose audit results at this Australian SSDL from 2001 to 2011 demonstrate the consistency of absorbed dose to water measurements, underpinned by the primary standard maintained at the Australian Radiation Protection and Nuclear Safety Agency (ARPANSA).

  14. Inter- and intra-laboratory standardization of TUNEL assay for assessment of sperm DNA fragmentation.

    PubMed

    Ribeiro, S; Sharma, R; Gupta, S; Cakar, Z; De Geyter, C; Agarwal, A

    2017-05-01

    One of the challenges with the sperm DNA fragmentation results is the inconsistency and the large variability in the results obtained by different techniques. The terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay quantifies the incorporation of fluoresceinated dUTP into single- and double-strand DNA breaks by labeling the 3'-OH terminal with TdT. The goal of this study was optimize the TUNEL protocol for assessment of sperm DNA fragmentation by standardization of the method and comparison of the data across two reference laboratories (i) at Basel, Switzerland and (ii) Cleveland Clinic, Ohio, USA. Semen samples from 31 subjects grouped into three cohorts. Sperm DNA fragmentation was data measured by two experienced operators at two different laboratories using identical semen samples, assay kit, protocol and acquisition settings using identical flow cytometers (BD Accuri C6). No significant differences were observed between the duplicates in any of the experiments performed. By including an additional washing step after fixation in paraformaldehyde, a high correlation was seen between the two laboratories (r = 0.94). A strong positive correlation was observed between the average sperm DNA fragmentation rates (r = 0.719). The mean sperm DNA fragmentation measured in each laboratory was similar. Both flow cytometers were identical in their settings and performance. This inter- and intra-laboratory study establishes that TUNEL is a reproducible assay when utilizing a standardized staining protocol and flow cytometer acquisition settings. Standardization and consensual guidelines for TUNEL validate the assay and establishes TUNEL as a robust test for measuring sperm DNA fragmentation especially in a multicenter setting. © 2017 American Society of Andrology and European Academy of Andrology.

  15. Towards the development of a fossil bone geochemical standard: an inter-laboratory study.

    PubMed

    Chavagnac, V; Milton, J A; Green, D R H; Breuer, J; Bruguier, O; Jacob, D E; Jong, T; Kamenov, G D; Le Huray, J; Liu, Y; Palmer, M R; Pourtalès, S; Roduhskin, I; Soldati, A; Trueman, C N; Yuan, H

    2007-09-19

    Ten international laboratories participated in an inter-laboratory comparison of a fossil bone composite with the objective of producing a matrix and structure-matched reference material for studies of the bio-mineralization of ancient fossil bone. We report the major and trace element compositions of the fossil bone composite, using in-situ method as well as various wet chemical digestion techniques. For major element concentrations, the intra-laboratory analytical precision (%RSD(r)) ranges from 7 to 18%, with higher percentages for Ti and K. The %RSD(r) are smaller than the inter-laboratory analytical precision (%RSD(R); <15-30%). Trace element concentrations vary by approximately 5 orders of magnitude (0.1 mg kg(-1) for Th to 10,000 mg kg(-1) for Ba). The intra-laboratory analytical precision %RSD(r) varies between 8 and 45%. The reproducibility values (%RSD(R)) range from 13 to <50%, although extreme value >100% was found for the high field strength elements (Hf, Th, Zr, Nb). The rare earth element (REE) concentrations, which vary over 3 orders of magnitude, have %RSD(r) and %RSD(R) values at 8-15% and 20-32%, respectively. However, the REE patterns (which are very important for paleo-environmental, taphonomic and paleo-oceanographic analyses) are much more consistent. These data suggest that the complex and unpredictable nature of the mineralogical and chemical composition of fossil bone makes it difficult to set-up and calibrate analytical instruments using conventional standards, and may result in non-spectral matrix effects. We propose an analytical protocol that can be employed in future inter-laboratory studies to produce a certified fossil bone geochemical standard.

  16. Crack-Detection Experiments on Simulated Turbine Engine Disks in NASA Glenn Research Center's Rotordynamics Laboratory

    NASA Technical Reports Server (NTRS)

    Woike, Mark R.; Abdul-Aziz, Ali

    2010-01-01

    The development of new health-monitoring techniques requires the use of theoretical and experimental tools to allow new concepts to be demonstrated and validated prior to use on more complicated and expensive engine hardware. In order to meet this need, significant upgrades were made to NASA Glenn Research Center s Rotordynamics Laboratory and a series of tests were conducted on simulated turbine engine disks as a means of demonstrating potential crack-detection techniques. The Rotordynamics Laboratory consists of a high-precision spin rig that can rotate subscale engine disks at speeds up to 12,000 rpm. The crack-detection experiment involved introducing a notch on a subscale engine disk and measuring its vibration response using externally mounted blade-tip-clearance sensors as the disk was operated at speeds up to 12 000 rpm. Testing was accomplished on both a clean baseline disk and a disk with an artificial crack: a 50.8-mm- (2-in.-) long introduced notch. The disk s vibration responses were compared and evaluated against theoretical models to investigate how successful the technique was in detecting cracks. This paper presents the capabilities of the Rotordynamics Laboratory, the baseline theory and experimental setup for the crack-detection experiments, and the associated results from the latest test campaign.

  17. Organic Contamination Baseline Study in NASA Johnson Space Center Astromaterials Curation Laboratories

    NASA Technical Reports Server (NTRS)

    Calaway, Michael J.; Allen, Carlton C.; Allton, Judith H.

    2014-01-01

    Future robotic and human spaceflight missions to the Moon, Mars, asteroids, and comets will require curating astromaterial samples with minimal inorganic and organic contamination to preserve the scientific integrity of each sample. 21st century sample return missions will focus on strict protocols for reducing organic contamination that have not been seen since the Apollo manned lunar landing program. To properly curate these materials, the Astromaterials Acquisition and Curation Office under the Astromaterial Research and Exploration Science Directorate at NASA Johnson Space Center houses and protects all extraterrestrial materials brought back to Earth that are controlled by the United States government. During fiscal year 2012, we conducted a year-long project to compile historical documentation and laboratory tests involving organic investigations at these facilities. In addition, we developed a plan to determine the current state of organic cleanliness in curation laboratories housing astromaterials. This was accomplished by focusing on current procedures and protocols for cleaning, sample handling, and storage. While the intention of this report is to give a comprehensive overview of the current state of organic cleanliness in JSC curation laboratories, it also provides a baseline for determining whether our cleaning procedures and sample handling protocols need to be adapted and/or augmented to meet the new requirements for future human spaceflight and robotic sample return missions.

  18. The Center for Research on Evaluation, Standards, and Student Testing (CRESST). ERIC/TM Digest.

    ERIC Educational Resources Information Center

    Baker, Eva L.; Linn, Robert L.

    The Center for Research on Evaluation, Standards, and Student Testing (CRESST) attempts to advance the understanding of educational quality by research and development on the design, implementation, analysis, and use of assessment information. CRESST's research programs are directed at five major goals: (1) provide leadership to improve assessment…

  19. 78 FR 54655 - Center for Devices and Radiological Health: Draft Standard Operating Procedure for Level 1...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-05

    ... HUMAN SERVICES Food and Drug Administration Center for Devices and Radiological Health: Draft Standard Operating Procedure for Level 1, Immediately in Effect Guidance Documents on Premarket Data Issues; Availability and Request for Comments AGENCY: Food and Drug Administration, HHS. ACTION: Notice; request...

  20. Standards, Firewalls, and General Classroom Mayhem: Implementing Student-Centered Technology Projects in the Elementary Classroom

    ERIC Educational Resources Information Center

    Hofer, Mark; Swan, Kathleen Owings

    2006-01-01

    Educators are simultaneously bombarded with both calls to integrate technology in meaningful ways into their teaching and to promote more student-centered activities which combine both content learning and higher-order thinking. This is no small task given the range of student abilities and interests, the increasing emphasis on state standards and…

  1. Microfluidic cartridges for DNA purification and genotyping processed in standard laboratory instruments

    NASA Astrophysics Data System (ADS)

    Focke, Maximilian; Mark, Daniel; Stumpf, Fabian; Müller, Martina; Roth, Günter; Zengerle, Roland; von Stetten, Felix

    2011-06-01

    Two microfluidic cartridges intended for upgrading standard laboratory instruments with automated liquid handling capability by use of centrifugal forces are presented. The first microfluidic cartridge enables purification of DNA from human whole blood and is operated in a standard laboratory centrifuge. The second microfluidic catridge enables genotyping of pathogens by geometrically multiplexed real-time PCR. It is operated in a slightly modified off-the-shelf thermal cycler. Both solutions aim at smart and cost-efficient ways to automate work flows in laboratories. The DNA purification cartridge automates all liquid handling steps starting from a lysed blood sample to PCR ready DNA. The cartridge contains two manually crushable glass ampoules with liquid reagents. The DNA yield extracted from a 32 μl blood sample is 192 +/- 30 ng which corresponds to 53 +/- 8% of a reference extraction. The genotyping cartridge is applied to analyse isolates of the multi-resistant Staphyloccus aureus (MRSA) by real-time PCR. The wells contain pre-stored dry reagents such as primers and probes. Evaluation of the system with 44 genotyping assays showed a 100% specificity and agreement with the reference assays in standard tubes. The lower limit of detection was well below 10 copies of DNA per reaction.

  2. An overview of the National Space Science data Center Standard Information Retrieval System (SIRS)

    NASA Technical Reports Server (NTRS)

    Shapiro, A.; Blecher, S.; Verson, E. E.; King, M. L. (Editor)

    1974-01-01

    A general overview is given of the National Space Science Data Center (NSSDC) Standard Information Retrieval System. A description, in general terms, the information system that contains the data files and the software system that processes and manipulates the files maintained at the Data Center. Emphasis is placed on providing users with an overview of the capabilities and uses of the NSSDC Standard Information Retrieval System (SIRS). Examples given are taken from the files at the Data Center. Detailed information about NSSDC data files is documented in a set of File Users Guides, with one user's guide prepared for each file processed by SIRS. Detailed information about SIRS is presented in the SIRS Users Guide.

  3. Bone Marrow Synoptic Reporting for Hematologic Neoplasms: Guideline From the College of American Pathologists Pathology and Laboratory Quality Center.

    PubMed

    Sever, Cordelia; Abbott, Charles L; de Baca, Monica E; Khoury, Joseph D; Perkins, Sherrie L; Reichard, Kaaren Kemp; Taylor, Ann; Terebelo, Howard R; Colasacco, Carol; Rumble, R Bryan; Thomas, Nicole E

    2016-09-01

    -There is ample evidence from the solid tumor literature that synoptic reporting improves accuracy and completeness of relevant data. No evidence-based guidelines currently exist for synoptic reporting for bone marrow samples. -To develop evidence-based recommendations to standardize the basic components of a synoptic report template for bone marrow samples. -The College of American Pathologists Pathology and Laboratory Quality Center convened a panel of experts in hematopathology to develop recommendations. A systematic evidence review was conducted to address 5 key questions. Recommendations were derived from strength of evidence, open comment feedback, and expert panel consensus. -Nine guideline statements were established to provide pathology laboratories with a framework by which to develop synoptic reporting templates for bone marrow samples. The guideline calls for specific data groups in the synoptic section of the pathology report; provides a list of evidence-based parameters for key, pertinent elements; and addresses ancillary testing. -A framework for bone marrow synoptic reporting will improve completeness of the final report in a manner that is clear, succinct, and consistent among institutions.

  4. Accuracy of the Clinical Diagnosis of Vaginitis Compared to a DNA Probe Laboratory Standard

    PubMed Central

    Lowe, Nancy K.; Neal, Jeremy L.; Ryan-Wenger, Nancy A.

    2009-01-01

    Objective To estimate the accuracy of the clinical diagnosis of the three most common causes of acute vulvovaginal symptoms (bacterial vaginosis, candidiasis vaginitis, and trichomoniasis vaginalis) using a traditional, standardized clinical diagnostic protocol compared to a DNA probe laboratory standard. Methods This prospective clinical comparative study had a sample of 535 active duty United States military women presenting with vulovaginal symptoms. Clinical diagnoses were made by research staff using a standardized protocol of history, physical examination including pelvic examination, determination of vaginal pH, vaginal fluid amines test, and wet-prep microscopy. Vaginal fluid samples were obtained for DNA analysis. The research clinicians were blinded to the DNA results. Results The participants described a presenting symptom of abnormal discharge (50%), itching/irritation (33%), malodor (10%), burning (4%), or others such as vulvar pain and vaginal discomfort. According to laboratory standard, there were 225 cases (42%) of bacterial vaginosis 76 cases (14%) of candidiasis vaginitis, 8 cases (1.5%) of trichomoniasis vaginalis, 87 cases of mixed infections (16%), and 139 negative cases (26%). For each single infection, the clinical diagnosis had a sensitivity and specificity of 80.8% and 70.0% for bacterial vaginosis; 83.8% and 84.8% for candidiasis vaginitis; and 84.6% and 99.6% for trichomoniasis vaginalis when compared to the DNA probe standard. Conclusion Compared to a DNA probe standard, clinical diagnosis is 81-85% sensitive and 70- 99% specific for bacterial vaginosis, candida vaginitis, and trichomoniasis. Even under research conditions that provided clinicians with sufficient time and materials to conduct a thorough and standardized clinical evaluation, the diagnosis and therefore, subsequent treatment of these common vaginal problems remains difficult. PMID:19104364

  5. Applying IEEE storage system management standards at the National Storage Laboratory

    SciTech Connect

    Louis, S.; Hyer, S.W.

    1992-12-04

    Since its inception in 1990, the IEEE Storage System Standards Working Group has identified storage-system management as an area in need of further development The pressing need for standards in storage-system management arises from the requirement to exchange management information and to provide control in a consistent predictable manner between the components of a storage system. An appropriate set of management standards will allow multiple vendors to supply storage management subsystems or applications that are integral to or compatible with new storage systems conforming to future IEEE standards. An early, practical application of IEEE storage-system-management work is being pursued at the National Storage Laboratory (NSL), a recently-formed industrial collaboration at Lawrence Livermore National Laboratory. The NSL`s purpose is to develop advanced hardware and software technologies for high-performance, distributed storage systems. Since storage system management is of critical concern, it is being explored in depth at the NSL. Work was initiated to define basic management requirements and develop generalized graphical-user-interface tools using remote-procedure-call mechanisms to implement the NSL`s conceptual management framework. Several constraints were imposed on the development of early versions of this work to maintain compatibility with the NSL`s underlying UniTree-based software architecture and to provide timely prototypes and proof of concept. The project leverages the on-going standards work of the IEEE Storage System Standards Working Group (SSSWG) and also explores some of the relationships and interactions between IEEE storage-system management and more well known management methods for distributed systems and networks. It will have long term benefits by providing ``real-life`` storage-system-management requirements to the IEEE SSSWG for validation of evolving standards.

  6. 75 FR 5088 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-01

    ... HUMAN SERVICES Substance Abuse and Mental Health Services Administration Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for Federal Agencies AGENCY: Substance... Standards Council of Canada (SCC) voted to end its Laboratory Accreditation Program for Substance...

  7. Development of a document management system for the standardization of clinical laboratory documents.

    PubMed

    Hwang, Sang-Hyun; Jung, Seon-Kyung; Kang, Soo-Jin; Cha, Hyo Soung; Chung, Seung Hyun; Lee, Do-Hoon

    2013-11-01

    Documentation is very important; a considerable number of documents exist for use in accreditation inspection. However, most laboratories do not effectively manage the processes of documentation, organization, and storage. The purpose of this study was to facilitate the establishment of a strategically effective and sustainably standardized document management system. A document code formatting system was modified by comparing the document list data received from 3 major university hospitals. In addition, a questionnaire regarding document code standardization was created and sent to 268 institutes to establish document classifications and generate a standard coding scheme. A computerized document management system was developed. Only 32% (8 out of 25 institutes) answered that they were able to identify all of the document types and their numbers. In total, 76% of institutes (19 out of 25) answered that a systematic document management system was necessary. Disorganized document files were systemized by classifying them into 8 major groups according to their characteristics: patient test records (T), test quality control (Q), manuals (M), equipment and environment management (E), statistics (S), division administration (A), department administration (R), and others (X). Our documentation system may serve as a basis for the standardization of documents and the creation of a document management system for all hospital laboratories.

  8. Ice Crystal Icing Engine Testing in the NASA Glenn Research Center's Propulsion Systems Laboratory: Altitude Investigation

    NASA Technical Reports Server (NTRS)

    Oliver, Michael J.

    2014-01-01

    The National Aeronautics and Space Administration (NASA) conducted a full scale ice crystal icing turbofan engine test using an obsolete Allied Signal ALF502-R5 engine in the Propulsion Systems Laboratory (PSL) at NASA Glenn Research Center. The test article used was the exact engine that experienced a loss of power event after the ingestion of ice crystals while operating at high altitude during a 1997 Honeywell flight test campaign investigating the turbofan engine ice crystal icing phenomena. The test plan included test points conducted at the known flight test campaign field event pressure altitude and at various pressure altitudes ranging from low to high throughout the engine operating envelope. The test article experienced a loss of power event at each of the altitudes tested. For each pressure altitude test point conducted the ambient static temperature was predicted using a NASA engine icing risk computer model for the given ambient static pressure while maintaining the engine speed.

  9. Advances in Engine Test Capabilities at the NASA Glenn Research Center's Propulsion Systems Laboratory

    NASA Technical Reports Server (NTRS)

    Pachlhofer, Peter M.; Panek, Joseph W.; Dicki, Dennis J.; Piendl, Barry R.; Lizanich, Paul J.; Klann, Gary A.

    2006-01-01

    The Propulsion Systems Laboratory at the National Aeronautics and Space Administration (NASA) Glenn Research Center is one of the premier U.S. facilities for research on advanced aeropropulsion systems. The facility can simulate a wide range of altitude and Mach number conditions while supplying the aeropropulsion system with all the support services necessary to operate at those conditions. Test data are recorded on a combination of steady-state and highspeed data-acquisition systems. Recently a number of upgrades were made to the facility to meet demanding new requirements for the latest aeropropulsion concepts and to improve operational efficiency. Improvements were made to data-acquisition systems, facility and engine-control systems, test-condition simulation systems, video capture and display capabilities, and personnel training procedures. This paper discusses the facility s capabilities, recent upgrades, and planned future improvements.

  10. [Law, guidelines and standards relevant to laboratory animals and animal experimentation].

    PubMed

    Takagaki, Y

    1982-04-01

    Presently available laws guidelines and standards relevant to laboratory animals and animal experimentation are reviewed. In Japan there exist Animal Protection and Management Act, and the Guideline for Animal Care and Management which was later prepared in accordance with the former act. These are comparable in quality to those seen in foreign countries such as the Cruelty to Animals Act of Great Britain or the Animal Welfare Act of U.S.A. As for laboratory animals, however, only basic matters appear there, and that is why the Japanese National Academy of Science in 1980 proposed legislation of a guideline for animal experimentation to the government. It is awaited to legislate sooner the one comparable to the Guidelines for the Regulation of Animal Experimentation prepared by ICLA in 1974. Other laws and regulations referred and discussed here are: *standards and guidelines for breeding, care and management of laboratory animals *veterinary laws and regulations which should be referred when domestic or wild animals are to be used for experiments *laws and regulations for general housing construction and environmental protection *regulations for particular experiments where radioisotopes, microbial infections or recombinant DNA are in use

  11. Towards the Standardization of a MATLAB-Based Control Systems Laboratory Experience for Undergraduate Students

    SciTech Connect

    Dixon, W.E.

    2001-03-15

    This paper seeks to begin a discussion with regard to developing standardized Computer Aided Control System Design (CACSD) tools that are typically utilized in an undergraduate controls laboratory. The advocated CACSD design tools are based on the popular, commercially available MATLAB environment, the Simulink toolbox, and the Real-Time Workshop toolbox. The primary advantages of the proposed approach are as follows: (1) the required computer hardware is low cost, (2) commercially available plants from different manufacturers can be supported under the same CACSD environment with no hardware modifications, (3) both the Windows and Linux operating systems can be supported via the MATLAB based Real-Time Windows Target and the Quality Real Time Systems (QRTS) based Real-Time Linux Target, and (4) the Simulink block diagram approach can be utilized to prototype control strategies; thereby, eliminating the need for low level programming skills. It is believed that the above advantages related to standardization of the CACSD design tools will facilitate: (1) the sharing of laboratory resources within each university (i.e., between departments) and (2) the development of Internet laboratory experiences for students (i.e., between universities).

  12. 42 CFR 493.1780 - Standard: Inspection of CLIA-exempt laboratories or laboratories requesting or issued a...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... laboratories or laboratories requesting or issued a certificate of accreditation. (a) Validation inspection. CMS or a CMS agent may conduct a validation inspection of any accredited or CLIA-exempt laboratory at... requirements of this part. (c) Noncompliance determination. If a validation or complaint inspection results in...

  13. 42 CFR 493.1780 - Standard: Inspection of CLIA-exempt laboratories or laboratories requesting or issued a...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... laboratories or laboratories requesting or issued a certificate of accreditation. (a) Validation inspection. CMS or a CMS agent may conduct a validation inspection of any accredited or CLIA-exempt laboratory at... requirements of this part. (c) Noncompliance determination. If a validation or complaint inspection results in...

  14. 42 CFR 493.1780 - Standard: Inspection of CLIA-exempt laboratories or laboratories requesting or issued a...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... laboratories or laboratories requesting or issued a certificate of accreditation. (a) Validation inspection. CMS or a CMS agent may conduct a validation inspection of any accredited or CLIA-exempt laboratory at... requirements of this part. (c) Noncompliance determination. If a validation or complaint inspection results in...

  15. 42 CFR 493.1780 - Standard: Inspection of CLIA-exempt laboratories or laboratories requesting or issued a...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... laboratories or laboratories requesting or issued a certificate of accreditation. (a) Validation inspection. CMS or a CMS agent may conduct a validation inspection of any accredited or CLIA-exempt laboratory at... requirements of this part. (c) Noncompliance determination. If a validation or complaint inspection results in...

  16. 42 CFR 493.1780 - Standard: Inspection of CLIA-exempt laboratories or laboratories requesting or issued a...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... laboratories or laboratories requesting or issued a certificate of accreditation. (a) Validation inspection. CMS or a CMS agent may conduct a validation inspection of any accredited or CLIA-exempt laboratory at... requirements of this part. (c) Noncompliance determination. If a validation or complaint inspection results in...

  17. Lawrence Livermore National Laboratory Site Specific Standard for Nonnuclear Safety Analysis

    SciTech Connect

    Failor, R; Beach, D R; Brereton, S; Hildum, J S; Ingram, C; Spagnolo, S; Van Warmerdam, C

    2003-05-06

    Lawrence Livermore National Laboratory (LLNL) and the NNSA Livermore Site Office teamed up to prepare a site specific work smart standard setting requirements for preparation of safety basis documents for LLNL non-nuclear operations and facilities. This standard documents how all hazards (biological, chemical, explosive, industrial, and radiological) shall be evaluated, classified, analyzed, and controls developed. This standard was developed to evaluate hazards at the facility level to mesh with LLNL's ISM system for reviewing hazards at the activity level. This standard presents an approach to establishing safety basis for non-nuclear operations and activities, taking a graded approach based on the potential for impacts to the health of collocated workers and the public. Direct worker safety is covered by LLNL's work activity level reviews and requirements. This standard includes streamlined mechanisms for classifying hazards based upon the unmitigated potential for human health impacts. A review or practices at several private industries, government laboratories, and DOE complex sites provided a benchmark and comparison of safety analysis processes. These approaches were compared with LLNL's existing systems, leading to a determination that facility specific safety basis documents added value to a rapid authorization for new work activities in LLNL facilities. A process for hazard classification that would be viewed as more credible than the previous facility classification system was developed, including a method allowing correlation of chemical inventories with TEEL* concentrations. A graded approach for classification of explosive hazards, consistent with the DOE Explosive Safety Manual, was included. The standard was designed to be complementary with LLNL's existing work smart standards covering the hazards identified in a facility. A standard for LLNL's Work Smart Standard set was prepared that will assure all hazards are covered with appropriate levels of

  18. [Networks of National Reference Centers and associated Consiliary Laboratories in Germany].

    PubMed

    Laude, G; Kist, M; Krause, G

    2012-02-01

    Since 1995, the Robert Koch-Institute in agreement with the Federal Ministry of Health in Germany has increased the funding of National Reference Centers (NRC) and Consiliary Laboratories (CL) for laboratory-based surveillance of selected infection pathogens and infectious disease syndromes. Their goal is to improve efficient protection from infections and to supplement infectious disease surveillance by monitoring selected pathogens. Currently there are 19 NRC and 48 CL, nominated for a duration of 3 years. In order to enhance the effectiveness and cooperation of the system, ten National Networks were launched in 2009. The aim of these networks is to facilitate exchange on diagnostic methods and prevention concepts and to improve the geographic coverage of the services. Furthermore, the networks provide an opportunity to work on issues beyond single pathogens more productively and efficiently. In addition, the inclusion of external and international specialists should to be included more often in the future. The activities of the networks are evaluated by the commission for infectious disease epidemiology. The commission develops promotion modalities to support collaboration between NRC and CL and to adapt it to more closely meet the requirements at the national and international levels.

  19. [The practical experience of quality control organization in the laboratory of Municipal consultative diagnostic center 1 of St. Petersburg].

    PubMed

    Ostroumova, M N; Mnuskina, M M

    2011-10-01

    The article specifies the functioning of quality control system in the laboratory of Municipal consultative diagnostic center i 1 of St. Petersburg. Initially, on the basis of interpretations of biological variations of every analyte, the requirements to analytical quality are developed. Subsequently, the actually attainable reproducibility of measurements and their bias is examined. The real analytical characteristics of 27 biochemical analytes are presented. The aggregate laboratory ratings are quoted based on the results of involvement in three EQAS programs since 2005, concerning biochemistry, immunochemistry and hematology. The important quality of laboratory research on its analytical stage is maintained by the interaction between inter-laboratory and regular external control.

  20. Description of the Structural Materials Information Center being established at the Oak Ridge National Laboratory

    SciTech Connect

    Oland, B.

    1990-01-01

    The US Nuclear Regulatory Commission has initiated a Structural aging Program at the Oak Ridge National Laboratory to identify potential structural safety issues related to continued service of nuclear power plants and to establish criteria for evaluating and resolving these issues. One of the tasks in this program focuses on the establishment of a Structural Materials Information Center where data and information on the time variation of concrete and concrete-related material properties under the influence of pertinent environmental stressors and aging factors will be collected and assembled into a database. This database will be used to assist in the prediction of potential long-term deterioration of critical structural components in nuclear power plants and to establish limits on hostile environmental exposure for these structures and materials. Materials property data and information will be collected at the Structural Materials Information Center from open literature, published references, and identifiable sources. Initially, the database will include portland cement concrete, metallic reinforcement, prestressing tendon and structural steel materials. Then, as data and information for other material systems are obtained, the database will be expanded and updated. The database will be developed and presented in two complementary formats. The Structural Materials Handbook will be published in four volumes as an expandable, hard copy handbook. The Materials Electronic Database will be developed to reflect the same information as contained in the handbook, but will be formatted for use on an IBM or IBM-compatible personal computer.

  1. Improved compliance with reporting standards: A retrospective analysis of Intersocietal Accreditation Commission Nuclear Cardiology Laboratories.

    PubMed

    Maddux, P Tim; Farrell, Mary Beth; Ewing, Joseph A; Tilkemeier, Peter L

    2016-11-09

    In 2011, Tilkemeier et al reported significant nuclear cardiology laboratory noncompliance with reporting standards. The aim of this study was to identify and examine noncompliant reporting elements with the Intersocietal Accreditation Commission Nuclear/PET (IAC) Reporting Standards and to compare compliance between 2008 and 2014. This was a retrospective study of compliance with 18 reporting elements utilizing accreditation findings from all laboratories applying for accreditation in 2008 and 2014. 1816 labs applying for initial or subsequent accreditation were analyzed for compliance. The mean reporting noncompliance per lab decreased from 2008 to 2014 (2.48 ± 2.67 to 1.24 ± 1.79, P < .001). Noncompliance decreased across lab types, labs with Certification Board of Nuclear Cardiology physicians on staff, and by geographic region (P < .001). Overall severity of reporting issues decreased. Facilities with compliant reports increased from 35.0% in 2008 to 57.1% in 2014 (P < .001). Continuing medical education, accreditation, and other instructional activities aimed at improving nuclear cardiology reporting appear to have made a positive impact over time with the number and severity of noncompliance decreased. More labs are now compliant with the IAC Standards and, thus, reporting guidelines. However, the need for continued educational efforts remains.

  2. Canadian Multicenter Laboratory Study for Standardized Second-Line Antimicrobial Susceptibility Testing of Mycobacterium tuberculosis ▿

    PubMed Central

    Sharma, Meenu; Thibert, Louise; Chedore, Pamela; Shandro, Cary; Jamieson, Frances; Tyrrell, Gregory; Christianson, Sara; Soualhine, Hafid; Wolfe, Joyce

    2011-01-01

    The purpose of this study was to establish a standardized protocol for second-line antimicrobial susceptibility testing of Mycobacterium tuberculosis using the Bactec MGIT 960 system in Canadian laboratories. Four Canadian public health laboratories compared the susceptibility testing results of 9 second-line antimicrobials between the Bactec 460 and Bactec MGIT 960 systems. Based on the data generated, we have established that the Bactec MGIT 960 system provides results comparable to those obtained with the previous Bactec 460 method. The critical concentrations established for the testing of the antimicrobials used are as follows: amikacin, 1 μg/ml; capreomycin, 2.5 μg/ml; ethionamide, 5 μg/ml; kanamycin, 2.5 μg/ml; linezolid, 1 μg/ml; moxifloxacin, 0.25 μg/ml; ofloxacin, 2 μg/ml; p-aminosalicylic acid, 4 μg/ml; rifabutin, 0.5 μg/ml. PMID:21998413

  3. Realization of the scale of high fiber optic power at three national standards laboratories

    SciTech Connect

    Envall, Jouni; Andersson, Anne; Petersen, Jan C.; Kaerhae, Petri

    2005-08-20

    Nowadays the transmission powers in optical telecommunication networks are often hundreds of milliwatts. Such high power levels are known to cause several nonlinear effects, thus affecting data transfer. Therefore, accurate measurements of such high power levels are required. The general issues that are to be considered when one is realizing a scale for high fiber optic power are discussed. The scales of the national standards laboratories in Finland, Sweden, and Denmark are described, and the results of a trilateral comparison of these scales are presented. The power range of the comparison was 1-200 mW. The results show that the stated measurement uncertainties of the three laboratories (1.3%-2.9%,k=2) are applicable over this power range.

  4. Canadian multicenter laboratory study for standardized second-line antimicrobial susceptibility testing of Mycobacterium tuberculosis.

    PubMed

    Sharma, Meenu; Thibert, Louise; Chedore, Pamela; Shandro, Cary; Jamieson, Frances; Tyrrell, Gregory; Christianson, Sara; Soualhine, Hafid; Wolfe, Joyce

    2011-12-01

    The purpose of this study was to establish a standardized protocol for second-line antimicrobial susceptibility testing of Mycobacterium tuberculosis using the Bactec MGIT 960 system in Canadian laboratories. Four Canadian public health laboratories compared the susceptibility testing results of 9 second-line antimicrobials between the Bactec 460 and Bactec MGIT 960 systems. Based on the data generated, we have established that the Bactec MGIT 960 system provides results comparable to those obtained with the previous Bactec 460 method. The critical concentrations established for the testing of the antimicrobials used are as follows: amikacin, 1 μg/ml; capreomycin, 2.5 μg/ml; ethionamide, 5 μg/ml; kanamycin, 2.5 μg/ml; linezolid, 1 μg/ml; moxifloxacin, 0.25 μg/ml; ofloxacin, 2 μg/ml; p-aminosalicylic acid, 4 μg/ml; rifabutin, 0.5 μg/ml.

  5. [Policies and standards applied to municipal day care centers in Rio de Janeiro].

    PubMed

    de Vasconcelos, Rafaela Moledo; Tancredi, Rinaldini Coralini Philippo; Marin, Victor Augustus

    2013-11-01

    Day care centers were first established in Brazil with the aim of reducing infant mortality rates, however the incidence of foodborne disease transmission has been on the increase. The World Health Organization (WHO) estimates that each year 1.8 million deaths worldwide occur in children under 5 years of age, which is attributed to the consumption of contaminated food. However, Brazilian legislation does not provide specific rules of operation for day care center kitchens. Thus, the scope of this study is to research the standards relating to the operation of day care centers, discussing the health regulations related to food production. By means of a review of electronic pages of various government organs, the regulations inherent to the operation and production of food in day care centers were examined. After scrutiny of the twenty-seven pieces of legislation found, there is a concern with water quality, supply of food, the control of pests and vectors, structural conditions and food policies. In spite of this, it was seen that not all the surveillance policies for the quality of food offered in day care centers are effective. Also observed was the lack of a specific regulation that establishes the quality criteria for safe handling of food in day care centers.

  6. Uranium Enrichment Standards of the Y-12 Nuclear Detection and Sensor Testing Center

    SciTech Connect

    Cantrell, J.

    2012-05-23

    The Y-12 National Security Complex has recently fabricated and characterized a new series of metallic uranium standards for use in the Nuclear Detection and Sensor Testing Center (NDSTC). Ten uranium metal disks with enrichments varying from 0.2 to 93.2% {sup 235}U were designed to provide researchers access to a wide variety of measurement scenarios in a single testing venue. Special care was taken in the selection of the enrichments in order to closely bracket the definitions of reactor fuel at 4% {sup 235}U and that of highly enriched uranium (HEU) at 20% {sup 235}U. Each standard is well characterized using analytical chemistry as well as a series of gamma-ray spectrometry measurements. Gamma-ray spectra of these standards are being archived in a reference library for use by customers of the NDSTC. A software database tool has been created that allows for easier access and comparison of various spectra. Information provided through the database includes: raw count data (including background spectra), regions of interest (ROIs), and full width half maximum calculations. Input is being sought from the user community on future needs including enhancements to the spectral database and additional Uranium standards, shielding configurations and detector types. A related presentation are planned for the INMM 53rd Annual Meeting (Hull, et al.), which describe new uranium chemical compound standards and testing opportunities at Y-12 Nuclear Detection and Sensor Testing Center (NDSTC).

  7. Multi-Standard Metadata Retrieval Framework at the Physical Oceanography Distributed Active Archive Center

    NASA Astrophysics Data System (ADS)

    Chung, N. T.; Huang, T.; Armstrong, E. M.; Gangl, M. E.

    2012-12-01

    With the vast amount of Earth Science data available, providing the user community with high quality metadata to facilitate information retrieval and exchange is integral to scientific research. The Physical Oceanography Distributed Active Archive Center (PO.DAAC) archives and distributes data products along with metadata pertinent to the physical state of the ocean. As one of the Earth Science data center for NASA, PO.DAAC is expected to work with multiple metadata standards. Since there is no single metadata standard that meets everyone's needs, a web-based framework has been designed and integrated as part of PO.DAAC's scalable Core Data System to enable users to quickly retrieve metadata in the format that they need. Currently, the framework supports the Open Search specification for data discovery, ISO 19115-2, Global Change Master Directory (GCMD) and Federal Geographic Data Committee (FGDC) metadata standards, with new metadata standards still being added. In this talk we will present the architecture behind the framework that makes it possible to support various metadata standards as well as the challenges we encountered.

  8. 75 FR 39023 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-07

    ... Hill Ave., Nashville, TN 37210, 615- 255-2400. (Formerly: Aegis Sciences Corporation, Aegis Analytical...--Toxicology Laboratory, 9601 I-630, Exit 7, Little Rock, AR 72205-7299, 501-202-2783. (Formerly: Forensic...-5295. Minneapolis Veterans Affairs Medical Center, Forensic Toxicology Laboratory, 1 Veterans Drive...

  9. 75 FR 27348 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-14

    ... Hill Ave., Nashville, TN 37210, 615- 255-2400. (Formerly: Aegis Sciences Corporation, Aegis Analytical... Laboratory, 9601 I-630, Exit 7, Little Rock, AR 72205-7299, 501-202-2783. (Formerly: Forensic Toxicology...-5295. Minneapolis Veterans Affairs Medical Center, Forensic Toxicology Laboratory, 1 Veterans Drive...

  10. 75 FR 45128 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-02

    ... Hill Ave., Nashville, TN 37210, 615- 255-2400, (Formerly: Aegis Sciences Corporation, Aegis Analytical... Laboratory, 9601 I-630, Exit 7, Little Rock, AR 72205-7299, 501-202-2783, (Formerly: Forensic Toxicology... Affairs Medical Center, Forensic Toxicology Laboratory, 1 Veterans Drive, Minneapolis, MN 55417, 612-725...

  11. 75 FR 75485 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-03

    ... Hill Ave., Nashville, TN 37210. 615- 255-2400. (Formerly: Aegis Sciences Corporation, Aegis Analytical...-Toxicology Laboratory, 11401 I-30, Little Rock, AR 72209-7056. 501-202-2783. (Formerly: Forensic Toxicology...-5295/800-950-5295. ] Minneapolis Veterans Affairs Medical Center, Forensic Toxicology Laboratory, 1...

  12. 75 FR 55795 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-14

    ... Hill Ave., Nashville, TN 37210, 615- 255-2400 (Formerly: Aegis Sciences Corporation, Aegis Analytical...-Toxicology Laboratory, 11401 I-30, Little Rock, AR 72209-7056, 501-202-2783 (Formerly: Forensic Toxicology... Affairs Medical Center, Forensic Toxicology Laboratory, 1 Veterans Drive, Minneapolis, MN 55417, 612-725...

  13. 75 FR 154 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-04

    ..., Exit 7, Little Rock, AR 72205-7299, 501-202-2783 (Formerly: Forensic Toxicology Laboratory Baptist... Affairs Medical Center, Forensic Toxicology Laboratory, 1 Veterans Drive, Minneapolis, MN 55417, 612-725... Testing Service, Inc., 5426 N.W. 79th Ave., Miami, FL 33166, 305-593-2260. U.S. Army Forensic Toxicology...

  14. Laboratory security and emergency response guidance for laboratories working with select agents. Centers for Disease Control and Prevention.

    PubMed

    Richmond, Jonathan Y; Nesby-O'Dell, Shanna L

    2002-12-06

    In recent years, concern has increased regarding use of biologic materials as agents of terrorism, but these same agents are often necessary tools in clinical and research microbiology laboratories. Traditional biosafety guidelines for laboratories have emphasized use of optimal work practices, appropriate containment equipment, well-designed facilities, and administrative controls to minimize risk of worker injury and to ensure safeguards against laboratory contamination. The guidelines discussed in this report were first published in 1999 (U.S. Department of Health and Human Services/CDC and National Institutes of Health. Biosafety in microbiological and biomedical laboratories [BMBL]. Richmond JY, McKinney RW, eds. 4th ed. Washington, DC: US Department of Health and Human Services, 1999 [Appendix F]). In that report, physical security concerns were addressed, and efforts were focused on preventing unauthorized entry to laboratory areas and preventing unauthorized removal of dangerous biologic agents from the laboratory. Appendix F of BMBL is now being revised to include additional information regarding personnel risk assessments, and inventory controls. The guidelines contained in this report are intended for laboratories working with select agents under biosafety-level 2, 3, or 4 conditions as described in Sections II and III of BMBL. These recommendations include conducting facility risk assessments and developing comprehensive security plans to minimize the probability of misuse of select agents. Risk assessments should include systematic, site-specific reviews of 1) physical security; 2) security of data and electronic technology systems; 3) employee security; 4) access controls to laboratory and animal areas; 5) procedures for agent inventory and accountability; 6) shipping/transfer and receiving of select agents; 7) unintentional incident and injury policies; 8) emergency response plans; and 9) policies that address breaches in security. The security plan

  15. Comparison of mixed flask culture and standardized laboratory model ecosystems for toxicity tests

    SciTech Connect

    Shannon, L.J.; Harrass, M.C.; Yount, J.D.; Walbridge, C.T.

    1985-09-01

    Two microecosystem protocols, the Standardized Aquatic Microcosm (SAM) method developed by Dr. Frieda Taub and associates (1982) and the Mixed Flask Culture (MFC) method of Dr. John Leffler (1981), were compared on the basis of their response to copper sulfate. These protocols differed in microcosm structure, age, and the variables monitored. Although responses were similar with both systems, the SAM procedure provided considerably more insight into the changes in population densities and nutrient cycling responsible for the observed ecosystem level changes. The SAM protocol was much more labor intensive and required about six times more laboratory effort than did the MFC protocol.

  16. Nanotechnology Laboratory Continues Partnership with FDA and National Institute of Standards and Technology | Poster

    Cancer.gov

    The NCI-funded Nanotechnology Characterization Laboratory (NCL)—a leader in evaluating promising nanomedicines to fight cancer—recently renewed its collaboration with the U.S. Food and Drug Administration (FDA) and the National Institute of Standards and Technology (NIST) to continue its groundbreaking work on characterizing nanomedicines and moving them toward the clinic. In partnership with NIST and the FDA, NCL has laid a solid, scientific foundation for using the power of nanotechnology to increase the potency and target the delivery

  17. Nanotechnology Laboratory Continues Partnership with FDA and National Institute of Standards and Technology | Poster

    Cancer.gov

    The NCI-funded Nanotechnology Characterization Laboratory (NCL)—a leader in evaluating promising nanomedicines to fight cancer—recently renewed its collaboration with the U.S. Food and Drug Administration (FDA) and the National Institute of Standards and Technology (NIST) to continue its groundbreaking work on characterizing nanomedicines and moving them toward the clinic. In partnership with NIST and the FDA, NCL has laid a solid, scientific foundation for using the power of nanotechnology to increase the potency and target the delivery

  18. Measurement of Henry's Law Constants Using Internal Standards: A Quantitative GC Experiment for the Instrumental Analysis or Environmental Chemistry Laboratory

    ERIC Educational Resources Information Center

    Ji, Chang; Boisvert, Susanne M.; Arida, Ann-Marie C.; Day, Shannon E.

    2008-01-01

    An internal standard method applicable to undergraduate instrumental analysis or environmental chemistry laboratory has been designed and tested to determine the Henry's law constants for a series of alkyl nitriles. In this method, a mixture of the analytes and an internal standard is prepared and used to make a standard solution (organic solvent)…

  19. Measurement of Henry's Law Constants Using Internal Standards: A Quantitative GC Experiment for the Instrumental Analysis or Environmental Chemistry Laboratory

    ERIC Educational Resources Information Center

    Ji, Chang; Boisvert, Susanne M.; Arida, Ann-Marie C.; Day, Shannon E.

    2008-01-01

    An internal standard method applicable to undergraduate instrumental analysis or environmental chemistry laboratory has been designed and tested to determine the Henry's law constants for a series of alkyl nitriles. In this method, a mixture of the analytes and an internal standard is prepared and used to make a standard solution (organic solvent)…

  20. Biomedical communications centers--a profile/evaluation instrument study of underlying standards.

    PubMed

    Glickman, J T; Eicholzer, W A

    1987-01-01

    The "ABCD Profile/Evaluation Instrument" offers directors of individual biomedical communications centers a way to measure their own progress towards meeting standards of excellence. It provides guidelines for review of biomedical communications centers in a model similar to the clinical and basic medical science departments' review. Based on the results of this study, many of the directors seemed to be looking for more formal structure of biomedical communications centers involvement. Use of the Profile/Evaluation Instrument helps address this need and allows discussion in areas such as the department's existence and function in relation to its host institution. In March of 1985, the ABCD used the Profile/Evaluation Instrument standards as parameters of responsibility and service provided by biomedical communications units in its analysis and response to the AAMC GPEP report (Allan and Bradford 1985). The instrument also triggers discussion of new areas of review needed within departments. The process of matching biomedical communications job requirements and assessment training criteria will be explored in the future expansion of the personnel section of the instrument. These and other areas are crucial to the survival and well-being of biomedical communications centers. The "ABCD Profile/Evaluation Instrument" establishes a concrete reference for external review by outside agencies and internal review by administration or the department directors themselves. It offers a continuing body of information that provides the basis for future planning in the field of biomedical communications.

  1. Physical examination instead of laboratory tests for most infants born to mothers colonized with group B Streptococcus: support for the Centers for Disease Control and Prevention's 2010 recommendations.

    PubMed

    Cantoni, Luigi; Ronfani, Luca; Da Riol, Rosalia; Demarini, Sergio

    2013-08-01

    To compare 2 approaches in the management of neonates at risk for group B Streptococcus early-onset sepsis: laboratory tests plus standardized physical examination and standardized physical examination alone. Prospective, sequential study over 2 consecutive 12-month periods, carried out in the maternity hospitals of the region Friuli-Venezia Giulia (north-eastern Italy). All term infants were included (7628 in the first period, 7611 in the second). In the first period, complete blood count and blood culture were required for all infants at risk, followed by a 48-hour period of observation with a standardized physical examination. In the second period, only standardized physical examination was performed. Study outcomes were: (1) number of neonates treated with antibiotics; and (2) time between onset of signs of possible sepsis and beginning of treatment. There was no difference between the 2 periods in the rate of maternal colonization (19.7% vs 19.8%, P = .8), or in other risk factors. The interval between onset of signs of sepsis and starting of antibiotics was not different in the 2 periods. Significantly fewer infants were treated with antibiotics in the second period (0.5% vs 1.2%, P < .001). Laboratory tests together with standardized physical examination seem to offer no advantage over standardized physical examination alone; the latter was associated with fewer antibiotic treatments. Our results are in agreement with the Center for Disease Control and Prevention's 2010 recommendations. Copyright © 2013 Mosby, Inc. All rights reserved.

  2. Laboratory Evaluation of Air Flow Measurement Methods for Residential HVAC Returns for New Instrument Standards

    SciTech Connect

    Walker, Iain; Stratton, Chris

    2015-08-01

    This project improved the accuracy of air flow measurements used in commissioning California heating and air conditioning systems in Title 24 (Building and Appliance Efficiency Standards), thereby improving system performance and efficiency of California residences. The research team at Lawrence Berkeley National Laboratory addressed the issue that typical tools used by contractors in the field to test air flows may not be accurate enough to measure return flows used in Title 24 applications. The team developed guidance on performance of current diagnostics as well as a draft test method for use in future evaluations. The study team prepared a draft test method through ASTM International to determine the uncertainty of air flow measurements at residential heating ventilation and air conditioning returns and other terminals. This test method, when finalized, can be used by the Energy Commission and other entities to specify required accuracy of measurement devices used to show compliance with standards.

  3. Changing resident test ordering behavior: a multilevel intervention to decrease laboratory utilization at an academic medical center.

    PubMed

    Vidyarthi, Arpana R; Hamill, Timothy; Green, Adrienne L; Rosenbluth, Glenn; Baron, Robert B

    2015-01-01

    Hospital laboratory test volume is increasing, and overutilization contributes to errors and costs. Efforts to reduce laboratory utilization have targeted aspects of ordering behavior, but few have utilized a multilevel collaborative approach. The study team partnered with residents to reduce unnecessary laboratory tests and associated costs through multilevel interventions across the academic medical center. The study team selected laboratory tests for intervention based on cost, volume, and ordering frequency (complete blood count [CBC] and CBC with differential, common electrolytes, blood enzymes, and liver function tests). Interventions were designed collaboratively with residents and targeted components of ordering behavior, including system changes, teaching, social marketing, academic detailing, financial incentives, and audit/feedback. Laboratory ordering was reduced by 8% cumulatively over 3 years, saving $2 019 000. By involving residents at every stage of the intervention and targeting multiple levels simultaneously, laboratory utilization was reduced and cost savings were sustained over 3 years. © 2014 by the American College of Medical Quality.

  4. An analysis of reference laboratory (send out) testing: an 8-year experience in a large academic medical center.

    PubMed

    MacMillan, Donna; Lewandrowski, Elizabeth; Lewandrowski, Kent

    2004-01-01

    Utilization of outside reference laboratories for selected laboratory testing is common in the United States. However, relatively little data exist in the literature describing the scope and impact of these services. In this study, we reviewed use of reference laboratory testing at the Massachusetts General Hospital, a large urban academic medical center in Boston, Massachusetts. A retrospective review of hospital and laboratory administrative records over an 8-year period from fiscal years (FY) 1995-2002. Over the 8 years studied, reference laboratory expenses increased 4.2-fold and totaled 12.4% of the total laboratory budget in FY 2002. Total reference laboratory test volume increased 4-fold to 68,328 tests in FY 2002 but represented only 1.06% of the total test volume in the hospital. The menu of reference laboratory tests comprised 946 tests (65.7% of the hospital test menu) compared to 494 (34.3%) of tests performed in house. The average unit cost of reference laboratory tests was essentially unchanged but was approximately 13 times greater than the average unit cost in the hospital laboratory. Much of the growth in reference laboratory cost can be attributed to the addition of new molecular, genetic, and microbiological assays. Four of the top 10 tests with the highest total cost in 2002 were molecular diagnostic tests that were recently added to the test menu. Reference laboratory testing comprises a major component of hospital clinical laboratory services. Although send out tests represent a small percentage of the total test volume, these services account for the majority of the hospital laboratory test menu and a disproportionate percentage of laboratory costs.

  5. Standardized and flexible eight colour flow cytometry panels harmonized between different laboratories to study human NK cell phenotype and function.

    PubMed

    Veluchamy, John P; Delso-Vallejo, María; Kok, Nina; Bohme, Fenna; Seggewiss-Bernhardt, Ruth; van der Vliet, Hans J; de Gruijl, Tanja D; Huppert, Volker; Spanholtz, Jan

    2017-03-10

    Advancements in multi-colour fluorescence activated cell sorting (FACS) panel warrant harmonized procedures to obtain comparable data between various laboratories. The intensifying clinical exploration of Natural Killer (NK) cell-based immunotherapy demands standardized and harmonized NK cell FACS panels and acquisition protocols. Eight colour FACS panels were designed to study human NK cell phenotype and function within peripheral blood mononuclear cells (PBMC). The panels were designed around fixed backbone markers and channels, covering antigens for non-NK lineage exclusion (CD3, TCRγδ, CD19, CD14, SYTOX(®) Blue) and NK cell selection (CD45, CD56, CD16), complemented with variable drop-in markers/channels to study NK cell phenotype (NKG2A, NKG2C, NKG2D and KIR2D) or NK cell function and activation (CD25, NKp44 and CD107a). Harmonized FACS set-up and data analysis for three different flow cytometers has been established, leading to highly comparable and reproducible data sets using the same PBMC reference samples (n = 6). Further studies of NK cells in fresh or cryopreserved PBMC samples (n = 12) confirmed that freezing and thawing of PBMC samples did not significantly affect NK phenotype or function. In conclusion, our data demonstrate that cryopreserved PBMC samples analysed by standardized FACS panels and harmonized analysis protocols will generate highly reliable data sets for multi-center clinical trials under validated conditions.

  6. Standardized and flexible eight colour flow cytometry panels harmonized between different laboratories to study human NK cell phenotype and function

    PubMed Central

    Veluchamy, John P.; Delso-Vallejo, María; Kok, Nina; Bohme, Fenna; Seggewiss-Bernhardt, Ruth; van der Vliet, Hans J.; de Gruijl, Tanja D.; Huppert, Volker; Spanholtz, Jan

    2017-01-01

    Advancements in multi-colour fluorescence activated cell sorting (FACS) panel warrant harmonized procedures to obtain comparable data between various laboratories. The intensifying clinical exploration of Natural Killer (NK) cell-based immunotherapy demands standardized and harmonized NK cell FACS panels and acquisition protocols. Eight colour FACS panels were designed to study human NK cell phenotype and function within peripheral blood mononuclear cells (PBMC). The panels were designed around fixed backbone markers and channels, covering antigens for non-NK lineage exclusion (CD3, TCRγδ, CD19, CD14, SYTOX® Blue) and NK cell selection (CD45, CD56, CD16), complemented with variable drop-in markers/channels to study NK cell phenotype (NKG2A, NKG2C, NKG2D and KIR2D) or NK cell function and activation (CD25, NKp44 and CD107a). Harmonized FACS set-up and data analysis for three different flow cytometers has been established, leading to highly comparable and reproducible data sets using the same PBMC reference samples (n = 6). Further studies of NK cells in fresh or cryopreserved PBMC samples (n = 12) confirmed that freezing and thawing of PBMC samples did not significantly affect NK phenotype or function. In conclusion, our data demonstrate that cryopreserved PBMC samples analysed by standardized FACS panels and harmonized analysis protocols will generate highly reliable data sets for multi-center clinical trials under validated conditions. PMID:28281564

  7. Design and verification of the shielding around the new Neutron Standards Laboratory (LPN) at CIEMAT.

    PubMed

    Méndez-Villafañe, R; Guerrero, J E; Embid, M; Fernández, R; Grandio, R; Pérez-Cejuela, P; Márquez, J L; Alvarez, F; Ortego, P

    2014-10-01

    The construction of the new Neutron Standards Laboratory at CIEMAT (Laboratorio de Patrones Neutrónicos) has been finalised and is ready to provide service. The facility is an ∼8 m×8 m×8 m irradiation vault, following the International Organization for Standardization 8529 recommendations. It relies on several neutron sources: a 5-GBq (5.8× 10(8) s(-1)) (252)Cf source and two (241)Am-Be neutron sources (185 and 11.1 GBq). The irradiation point is located 4 m over the ground level and in the geometrical centre of the room. Each neutron source can be moved remotely from its storage position inside a water pool to the irradiation point. Prior to this, an important task to design the neutron shielding and to choose the most appropriate materials has been developed by the Radiological Security Unit and the Ionizing Radiations Metrology Laboratory. MCNPX was chosen to simulate the irradiation facility. With this information the walls were built with a thickness of 125 cm. Special attention was put on the weak points (main door, air conditioning system, etc.) so that the ambient dose outside the facility was below the regulatory limits. Finally, the Radiation Protection Unit carried out a set of measurements in specific points around the installation with an LB6411 neutron monitor and a Reuter-Stokes high-pressure ion chamber to verify experimentally the results of the simulation.

  8. Policy for therapeutic acupuncture in an academic health center: a model for standard policy development.

    PubMed

    Myklebust, Monica; Colson, James; Kaufman, Jacqueline; Winsauer, Jeffery; Zhang, Yu Quin; Harris, Richard E

    2006-12-01

    Acupuncture as a therapeutic modality offers multiple applications. Its effectiveness coupled with its general acceptance by conventional health care professionals makes it one of the first complementary and alternative medicine (CAM) modalities to be incorporated in an integrative approach to care. However, few centers that offer acupuncture have written standard policies to regulate its use. This lack of standard policies may impede provision of quality care, serve as a barrier to cross-institutional data collection and clinical application of that data, and may put health care professionals and institutions at risk when credentialing or malpractice liability has not been clearly addressed. Here we present a policy for acupuncture, created by a diverse group of health care professionals at the University of Michigan Health System. It may function as a generalizable template for standard policy development by institutions incorporating acupuncture.

  9. NASA's Corrosion Technology Laboratory at the Kennedy Space Center: Anticipating, Managing, and Preventing Corrosion

    NASA Technical Reports Server (NTRS)

    Calle, Luz Marina

    2014-01-01

    Corrosion is the degradation of a material that results from its interaction with the environment. The marine environment at NASAs Kennedy Space Center (KSC) has been documented by ASM International (formerly American Society for Metals) as the most corrosive in the United States. With the introduction of the Space Shuttle in 1981, the already highly corrosive conditions at the launch pads were rendered even more severe by the 70 tons of highly corrosive hydrochloric acid that were generated by the solid rocket boosters. Numerous failures at the launch pads are caused by corrosion.The structural integrity of ground infrastructure and flight hardware is critical to the success, safety, cost, and sustainability of space missions. As a result of fifty years of experience with launch and ground operations in a natural marine environment that is highly corrosive, NASAs Corrosion Technology Laboratory at KSC is a major source of corrosion control expertise in the launch and other environments. Throughout its history, the Laboratory has evolved from what started as an atmospheric exposure facility near NASAs launch pads into a world-wide recognized capability that provides technical innovations and engineering services in all areas of corrosion for NASA and external customers.This presentation will provide a historical overview of the role of NASAs Corrosion Technology in anticipating, managing, and preventing corrosion. One important challenge in managing and preventing corrosion involves the detrimental impact on humans and the environment of what have been very effective corrosion control strategies. This challenge has motivated the development of new corrosion control technologies that are more effective and environmentally friendly. Strategies for improved corrosion protection and durability can have a huge impact on the economic sustainability of human spaceflight operations.

  10. Russian Tu-144LL SST Flying Laboratory Landing with Drag Chutes at Zhukovsky Air Development Center

    NASA Technical Reports Server (NTRS)

    1997-01-01

    The modified Tupolev Tu-144 supersonic flying laboratory touches down and deploys a trio of drag chutes following a test flight at the Zhukovsky Air Development Center near Moscow, Russia, in July 1997. NASA teamed with American and Russian aerospace industries for an extended period in a joint international research program featuring the Russian-built Tu-144LL supersonic aircraft. The object of the program was to develop technologies for a proposed future second-generation supersonic airliner to be developed in the 21st Century. The aircraft's initial flight phase began in June 1996 and concluded in February 1998 after 19 research flights. A shorter follow-on program involving seven flights began in September 1998 and concluded in April 1999. All flights were conducted in Russia from Tupolev's facility at the Zhukovsky Air Development Center near Moscow. The centerpiece of the research program was the Tu 144LL, a first-generation Russian supersonic jetliner that was modified by its developer/builder, Tupolev ANTK (aviatsionnyy nauchno-tekhnicheskiy kompleks-roughly, aviation technical complex), into a flying laboratory for supersonic research. Using the Tu-144LL to conduct flight research experiments, researchers compared full-scale supersonic aircraft flight data with results from models in wind tunnels, computer-aided techniques, and other flight tests. The experiments provided unique aerodynamic, structures, acoustics, and operating environment data on supersonic passenger aircraft. Data collected from the research program was being used to develop the technology base for a proposed future American-built supersonic jetliner. Although actual development of such an advanced supersonic transport (SST) is currently on hold, commercial aviation experts estimate that a market for up to 500 such aircraft could develop by the third decade of the 21st Century. The Tu-144LL used in the NASA-sponsored research program was a 'D' model with different engines than were used

  11. Russian Tu-144LL SST Flying Laboratory Takeoff at Zhukovsky Air Development Center

    NASA Technical Reports Server (NTRS)

    1997-01-01

    With its nose drooped and canards extended, the Tupolev Tu-144LL supersonic flying laboratory lifts off from the Zhukovsky Air Development Center near Moscow, Russia on a 1997 test flight. NASA teamed with American and Russian aerospace industries for an extended period in a joint international research program featuring the Russian-built Tu-144LL supersonic aircraft. The object of the program was to develop technologies for a proposed future second-generation supersonic airliner to be developed in the 21st Century. The aircraft's initial flight phase began in June 1996 and concluded in February 1998 after 19 research flights. A shorter follow-on program involving seven flights began in September 1998 and concluded in April 1999. All flights were conducted in Russia from Tupolev's facility at the Zhukovsky Air Development Center near Moscow. The centerpiece of the research program was the Tu 144LL, a first-generation Russian supersonic jetliner that was modified by its developer/builder, Tupolev ANTK (aviatsionnyy nauchno-tekhnicheskiy kompleks-roughly, aviation technical complex), into a flying laboratory for supersonic research. Using the Tu-144LL to conduct flight research experiments, researchers compared full-scale supersonic aircraft flight data with results from models in wind tunnels, computer-aided techniques, and other flight tests. The experiments provided unique aerodynamic, structures, acoustics, and operating environment data on supersonic passenger aircraft. Data collected from the research program was being used to develop the technology base for a proposed future American-built supersonic jetliner. Although actual development of such an advanced supersonic transport (SST) is currently on hold, commercial aviation experts estimate that a market for up to 500 such aircraft could develop by the third decade of the 21st Century. The Tu-144LL used in the NASA-sponsored research program was a 'D' model with different engines than were used in production

  12. Russian Tu-144LL SST Flying Laboratory Landing at Zhukovsky Air Development Center

    NASA Technical Reports Server (NTRS)

    1997-01-01

    The Tupolev Tu-144LL supersonic flying laboratory touches down at the Zhukovsky Air Development Center near Moscow, Russia, following a 1997 test flight. NASA teamed with American and Russian aerospace industries for an extended period in a joint international research program featuring the Russian-built Tu-144LL supersonic aircraft. The object of the program was to develop technologies for a proposed future second-generation supersonic airliner to be developed in the 21st Century. The aircraft's initial flight phase began in June 1996 and concluded in February 1998 after 19 research flights. A shorter follow-on program involving seven flights began in September 1998 and concluded in April 1999. All flights were conducted in Russia from Tupolev's facility at the Zhukovsky Air Development Center near Moscow. The centerpiece of the research program was the Tu 144LL, a first-generation Russian supersonic jetliner that was modified by its developer/builder, Tupolev ANTK (aviatsionnyy nauchno-tekhnicheskiy kompleks-roughly, aviation technical complex), into a flying laboratory for supersonic research. Using the Tu-144LL to conduct flight research experiments, researchers compared full-scale supersonic aircraft flight data with results from models in wind tunnels, computer-aided techniques, and other flight tests. The experiments provided unique aerodynamic, structures, acoustics, and operating environment data on supersonic passenger aircraft. Data collected from the research program was being used to develop the technology base for a proposed future American-built supersonic jetliner. Although actual development of such an advanced supersonic transport (SST) is currently on hold, commercial aviation experts estimate that a market for up to 500 such aircraft could develop by the third decade of the 21st Century. The Tu-144LL used in the NASA-sponsored research program was a 'D' model with different engines than were used in production-model aircraft. Fifty experiments

  13. Russian Tu-144LL SST Flying Laboratory Landing at Zhukovsky Air Development Center

    NASA Technical Reports Server (NTRS)

    1997-01-01

    The Tupolev Tu-144LL supersonic flying laboratory lifts off from the Zhukovsky Air Development Center near Moscow, Russia, on a 1997 test flight. NASA teamed with American and Russian aerospace industries for an extended period in a joint international research program featuring the Russian-built Tu-144LL supersonic aircraft. The object of the program was to develop technologies for a proposed future second-generation supersonic airliner to be developed in the 21st Century. The aircraft's initial flight phase began in June 1996 and concluded in February 1998 after 19 research flights. A shorter follow-on program involving seven flights began in September 1998 and concluded in April 1999. All flights were conducted in Russia from Tupolev's facility at the Zhukovsky Air Development Center near Moscow. The centerpiece of the research program was the Tu 144LL, a first-generation Russian supersonic jetliner that was modified by its developer/builder, Tupolev ANTK (aviatsionnyy nauchno-tekhnicheskiy kompleks-roughly, aviation technical complex), into a flying laboratory for supersonic research. Using the Tu-144LL to conduct flight research experiments, researchers compared full-scale supersonic aircraft flight data with results from models in wind tunnels, computer-aided techniques, and other flight tests. The experiments provided unique aerodynamic, structures, acoustics, and operating environment data on supersonic passenger aircraft. Data collected from the research program was being used to develop the technology base for a proposed future American-built supersonic jetliner. Although actual development of such an advanced supersonic transport (SST) is currently on hold, commercial aviation experts estimate that a market for up to 500 such aircraft could develop by the third decade of the 21st Century. The Tu-144LL used in the NASA-sponsored research program was a 'D' model with different engines than were used in production-model aircraft. Fifty experiments were

  14. Russian Tu-144LL SST Flying Laboratory Landing at Zhukovsky Air Development Center

    NASA Technical Reports Server (NTRS)

    1997-01-01

    The Tupolev Tu-144LL supersonic flying laboratory touches down at the Zhukovsky Air Development Center near Moscow, Russia, following a 1997 test flight. NASA teamed with American and Russian aerospace industries for an extended period in a joint international research program featuring the Russian-built Tu-144LL supersonic aircraft. The object of the program was to develop technologies for a proposed future second-generation supersonic airliner to be developed in the 21st Century. The aircraft's initial flight phase began in June 1996 and concluded in February 1998 after 19 research flights. A shorter follow-on program involving seven flights began in September 1998 and concluded in April 1999. All flights were conducted in Russia from Tupolev's facility at the Zhukovsky Air Development Center near Moscow. The centerpiece of the research program was the Tu 144LL, a first-generation Russian supersonic jetliner that was modified by its developer/builder, Tupolev ANTK (aviatsionnyy nauchno-tekhnicheskiy kompleks-roughly, aviation technical complex), into a flying laboratory for supersonic research. Using the Tu-144LL to conduct flight research experiments, researchers compared full-scale supersonic aircraft flight data with results from models in wind tunnels, computer-aided techniques, and other flight tests. The experiments provided unique aerodynamic, structures, acoustics, and operating environment data on supersonic passenger aircraft. Data collected from the research program was being used to develop the technology base for a proposed future American-built supersonic jetliner. Although actual development of such an advanced supersonic transport (SST) is currently on hold, commercial aviation experts estimate that a market for up to 500 such aircraft could develop by the third decade of the 21st Century. The Tu-144LL used in the NASA-sponsored research program was a 'D' model with different engines than were used in production-model aircraft. Fifty experiments

  15. Pain management standards in the eighth edition of the Guide for the Care and Use of Laboratory Animals.

    PubMed

    Carbone, Larry

    2012-05-01

    The eighth edition Guide for the Care and Use of Laboratory Animals sets standards for diverse laboratory animal care and use practices. It frames its standards as performance, engineering, and practice standards, with a strong emphasis on performance standards, allowing for multiple routes to clearly defined outcomes. Standards intended to be upheld rigorously are indicated through the use of must in the description, and those accommodating more flexibility are indicated through may and should statements. With respect to pain management standards, a fourth type of standard-the jurisdictional standard-has been prevalent through all 8 editions of the Guide. Under jurisdictional standards, specific methods and outcomes for measuring, preventing, or alleviating pain are not detailed, but the various jurisdictions of veterinarian, investigator, and IACUC are elaborated. Although data on pain management in laboratory animals has expanded greatly since the 1996 Guide, the eighth (2011) edition does not contain major new standards or guidance regarding animal pain management. Requirements for veterinary and IACUC involvement remain as in prior editions, and the duty of veterinarians and scientists to stay abreast of new developments is expected to drive refinement of animal pain management institution by institution. The current article details selected specific pain management standards in the 2011 Guide, lists topics in pain management for which the Guide does not set clear standards, and suggests possible standards for those topics.

  16. An exploration of certain factors and skills impacting effective laboratory-centered, inquiry-focused science instruction

    NASA Astrophysics Data System (ADS)

    Lombardo, Anthony S.

    The research reported herein addressed the need to examine the impact of certain factors and skills that science teachers' professional judgments indicate as significant in being able to carry out inquiry focused laboratory centered instruction in grades 7--12. Four groups of practicing science teachers participated in the study. Group A included 16 urban science teachers who had previously completed long term professional development in the laboratory-centered, inquiry-focused approach to science instruction. Group B included 24 urban science teachers who had not received long term professional development. Group C included 13 science teachers from suburban school districts, most of whom received no long term professional development in the laboratory-centered, inquiry-focused approach to science instruction. Group D was derived from groups A, B, and C and were identified, following criteria, to have a clear understanding of the inquiry focused approach to science instruction as described by the Levels of Inquiry Matrix. A survey instrument, developed to obtain the professional judgments of teachers, was designed so that the results could be analyzed using nonparametric statistics. The survey requested that the teachers rate 19 factors that had an impact on their ability to carry out laboratory-centered, inquiry-focused instruction. The survey also collected data about the environments in which these teachers carry out instruction as well as the skills that the teachers believe should be developed by students from involvement in this approach to science instruction. Results indicate that science teachers from all four study groups agreed that access to laboratory facilities, safety equipment, and laboratory instruments are most important to be able to effectively carry out instruction that is laboratory centered and inquiry focused. Other factors ranked behind these but also highly rated were teacher training, administrative support, laboratory supplies, and

  17. Laryngoscope Illuminance in a Tertiary Care Medical Center: Industry Standards and Implications for Quality Laryngoscopy.

    PubMed

    Murphy, Michael K; Volsky, Peter G; Darrow, David H

    2015-11-01

    To test the hypothesis that a substantial proportion of laryngoscopes exhibit substandard illuminance by comparing laryngoscope illuminance in a tertiary-level medical center to established standards and identifying features associated with poor illuminance. Cross-sectional observational study. Academic tertiary care medical center (level 1 trauma center, specialty cardiac hospital, and general hospital). Laryngoscopes from main, cardiac, and outpatient operating rooms; emergency department; and code carts were tested using a standard technique. Illuminance (lux) was chosen as the outcome measure. Benchmarks were derived from the International Standards Organization and medical literature. Light types included incandescent bulb, light-emitting diode, and xenon. Personnel were surveyed regarding maintenance practices. Across all hospitals, 691 laryngoscopes were tested. Mean (SD) illuminance was 810 (700) lux for incandescent bulb-on-blade designs (n = 237), 1860 (1220) lux for incandescent bulb in-handle designs (n = 79), 4730 (3210) lux for LED (n = 354), and 28,800 (34,500) lux for xenon (n = 21). Seven percent of units failed to turn on (n = 45). Using an established threshold of 867 lux, 28% of devices (47% of incandescent, 12% of LED, and 10% of xenon) were substandard. All laryngoscopes were cleaned according to standard protocols following use; no preventive maintenance was reported. Twenty-eight percent of laryngoscopes in a tertiary care hospital exhibit substandard illuminance; these results corroborate the findings of our inaugural study on this subject. Consequently, our hospital is instituting changes to reduce the likelihood of substandard performance by laryngoscopes in circulation. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2015.

  18. The Montpellier Leishmania Collection, from a Laboratory Collection to a Biological Resource Center: A 39-Year-Long Story.

    PubMed

    Pratlong, Francine; Balard, Yves; Lami, Patrick; Talignani, Loïc; Ravel, Christophe; Dereure, Jacques; Lefebvre, Michèle; Serres, Ghislaine; Bastien, Patrick; Dedet, Jean-Pierre

    2016-12-01

    We report the development of a laboratory collection of Leishmania that was initiated in 1975 and, after 39 years, has become an international Biological Resource Center (BRC-Leish, Montpellier, France, BioBank No. BB-0033-00052), which includes 6353 strains belonging to 36 Leishmania taxa. This is a retrospective analysis of the technical and organizational changes that have been adopted over time to take into account the technological advances and related modifications in the collection management and quality system. The technical improvements concerned the culture and cryopreservation techniques, strain identification by isoenzymatic and molecular techniques, data computerization and quality management to meet the changes in international standards, and in the cryogenic and microbiological safety procedures. The BRC is working toward obtaining the NF-S 96-900 certification in the coming years. Our long-term expertise in Leishmania storage and typing and collection maintenance should encourage field epidemiologists and clinical practitioners in endemic countries to secure their own strain collection with the help of the French BRC-Leish.

  19. US Army Research Laboratory (ARL) Standard for Characterization of Electric-Field Sensors, 10 Hz to 10 kHz

    DTIC Science & Technology

    2016-11-01

    characterization. Improvements are currently being made to the testing facility to allow greater electric -field strengths to be generated while maintaining 1...Laboratory BNC Bayonet Neill–Concelman DC direct current EFNSD electric -field-referred noise spectral density FFT fast Fourier transform GRS...ARL-TR-7880 ● NOV 2016 US Army Research Laboratory US Army Research Laboratory (ARL) Standard for Characterization of Electric

  20. Microbial process translation--laboratory to pilot plant at the Frederick Cancer Research Center.

    PubMed

    Langlykke, A F

    1978-01-01

    In summary, operations in the FCRC pilot plant have included training an operating staff, operability trials, equipment modification and repair, and supplementation of the original equipment to gain greater versatility. In addition to effort spent on proving and improving the capacity of the pilot plant, development studies and production operations involving translation of laboratory operations to pilot level or volume have included: 1. Development of a production process for interferon as described above. As a by-product of the interferon program, samples of cell culture have been studied in the Basic Research Division of FCRC for the production of lymphokines. 2. Production of starting materials (cell paste) for carboxypeptidase G1, using three different organisms, and production of refined material from the FCRC 252 organism as described herein. 3. Production of large quantities of crude phenylalanine ammonia lyase in the form of cell paste for Prof. Creed Abell at the University of Texas, Medical Branch, at Galveston,. 4. Production of a crude staphylococcal nuclease for the program of Dr. David Sachs, National Cancer Institute, Bethesda, Maryland. 5. Developmental studies and limited production of a crude cysteine desulfhydrase according to the protocols of Dr. J. Uren, Sidney Farber Cancer Center, Boston, Massachusetts. 6. Preliminary production studies on the agent produced by Culture FCRC 14, discovered in the CFL search program. 7. Developmental fermentation studies on the antitumor antibiotic, piperazinedione 593A [6], in preparation for production of quantities of this antibiotic to support clinical studies under the auspices of the National Cancer Institute.

  1. NASA's Corrosion Technology Laboratory at the Kennedy Space Center: Anticipating, Managing, and Preventing Corrosion

    NASA Technical Reports Server (NTRS)

    Calle, Luz Marina

    2015-01-01

    The marine environment at NASAs Kennedy Space Center (KSC) has been documented by ASM International (formerly American Society for Metals) as the most corrosive in North America. With the introduction of the Space Shuttle in 1981, the already highly corrosive conditions at the launch pads were rendered even more severe by the highly corrosive hydrochloric acid (HCl) generated by the solid rocket boosters (SRBs). Numerous failures at the launch pads are caused by corrosion. The structural integrity of ground infrastructure and flight hardware is critical to the success, safety, cost, and sustainability of space missions. NASA has over fifty years of experience dealing with unexpected failures caused by corrosion and has developed expertise in corrosion control in the launch and other environments. The Corrosion Technology Laboratory at KSC evolved, from what started as an atmospheric exposure test site near NASAs launch pads, into a capability that provides technical innovations and engineering services in all areas of corrosion for NASA, external partners, and customers.This paper provides a chronological overview of NASAs role in anticipating, managing, and preventing corrosion in highly corrosive environments. One important challenge in managing and preventing corrosion involves the detrimental impact on humans and the environment of what have been very effective corrosion control strategies. This challenge has motivated the development of new corrosion control technologies that are more effective and environmentally friendly. Strategies for improved corrosion protection and durability can have a huge impact on the economic sustainability of human spaceflight operations.

  2. A roadmap for academic health centers to establish good laboratory practice-compliant infrastructure.

    PubMed

    Adamo, Joan E; Bauer, Gerhard; Berro, Marlene; Burnett, Bruce K; Hartman, Karen A; Masiello, Lisa M; Moorman-White, Diane; Rubinstein, Eric P; Schuff, Kathryn G

    2012-03-01

    Prior to human clinical trials, nonclinical safety and toxicology studies are required to demonstrate that a new product appears safe for human testing; these nonclinical studies are governed by good laboratory practice (GLP) regulations. As academic health centers (AHCs) embrace the charge to increase the translation of basic science research into clinical discoveries, researchers at these institutions increasingly will be conducting GLP-regulated nonclinical studies. Because the consequences for noncompliance are severe and many AHC researchers are unfamiliar with Food and Drug Administration regulations, the authors describe the regulatory requirements for conducting GLP research, including the strict documentation requirements, the necessary personnel training, the importance of study monitoring, and the critical role that compliance oversight plays in the process. They then explain the process that AHCs interested in conducting GLP studies should take before the start of their research program, including conducting a needs assessment and a gap analysis and selecting a model for GLP compliance. Finally, the authors identify and analyze several critical barriers to developing and implementing a GLP-compliant infrastructure at an AHC. Despite these challenges, the capacity to perform such research will help AHCs to build and maintain competitive research programs and to facilitate the successful translation of faculty-initiated research from nonclinical studies to first-in-human clinical trials.

  3. A Roadmap for Academic Health Centers to Establish Good Laboratory Practice-Compliant Infrastructure

    PubMed Central

    Adamo, Joan E.; Bauer, Gerhard; Berro, Marlene; Burnett, Bruce K.; Hartman, Karen A.; Masiello, Lisa M.; Moorman-White, Diane; Rubinstein, Eric P.; Schuff, Kathryn G.

    2012-01-01

    Prior to human clinical trials, nonclinical safety and toxicology studies are required to demonstrate that a new product appears safe for human testing; these nonclinical studies are governed by good laboratory practice (GLP) regulations. As academic health centers (AHCs) embrace the charge to increase the translation of basic science research into clinical discoveries, researchers at these institutions increasingly will be conducting GLP-regulated nonclinical studies. Because the consequences for noncompliance are severe and many AHC researchers are unfamiliar with Food and Drug Administration (FDA) regulations, the authors describe the regulatory requirements for conducting GLP research, including the strict documentation requirements, the necessary personnel training, the importance of study monitoring, and the critical role that compliance oversight plays in the process. They then explain the process that AHCs interested in conducting GLP studies should take prior to the start of their research program, including conducting a needs assessment and a gap analysis and selecting a model for GLP compliance. Finally, the authors identify and analyze several critical barriers to developing and implementing a GLP-compliant infrastructure at an AHC. Despite these challenges, the capacity to perform such research will help AHCs to build and maintain competitive research programs and to facilitate the successful translation of faculty-initiated research from nonclinical studies to first-in-human clinical trials. PMID:22373618

  4. Inter-laboratory comparison study on measuring semi-volatile organic chemicals in standards and air samples.

    PubMed

    Su, Yushan; Hung, Hayley

    2010-11-01

    Measurements of semi-volatile organic chemicals (SVOCs) were compared among 21 laboratories from 7 countries through the analysis of standards, a blind sample, an air extract, and an atmospheric dust sample. Measurement accuracy strongly depended on analytes, laboratories, and types of standards and samples. Intra-laboratory precision was generally good with relative standard deviations (RSDs) of triplicate injections <10% and with median differences of duplicate samples between 2.1 and 22%. Inter-laboratory variability, measured by RSDs of all measurements, was in the range of 2.8-58% in analyzing standards, and 6.9-190% in analyzing blind sample and air extract. Inter-laboratory precision was poorer when samples were subject to cleanup processes, or when SVOCs were quantified at low concentrations. In general, inter-laboratory differences up to a factor of 2 can be expected to analyze atmospheric SVOCs. When comparing air measurements from different laboratories, caution should be exercised if the data variability is less than the inter-laboratory differences. 2010. Published by Elsevier Ltd. All rights reserved.

  5. A Virtual Geophysical Network: Using Industry Standard Technology to Link Geographically Distributed Sensors and Data Centers

    NASA Astrophysics Data System (ADS)

    Ahern, T. K.; Benson, R. B.; Crotwell, H. P.

    2003-12-01

    The IRIS Data Management System has long supported distributed data centers as a method of providing scientific researchers access to data from seismological networks around the world. For nearly a decade, the NetDC system used email as the method through which users could access data centers located around the globe in a seamless fashion. More recently the IRIS DMC has partnered with the University of South Carolina to develop a new method through which a virtual data center can be created. The Common Object Request Broker Architecture (CORBA) technology is an industry standard distributed computing architecture. Traditionally used by major corporations, IRIS has developed a Data Handling Interface (DHI) system that is capable of connecting services at participating data centers (servers) to applications running on end-users computing platforms (clients). For seismology we have identified three services. 1) A network service that provides information about geophysical observatories around the world such as where the sensors exist, what types of information are recorded on the sensors, and calibration information that allows proper use of the data, 2) an event service that allows applications to access information about earthquakes and seismological events and 3) waveform services that allow users to gain access to seismograms or time series data from other geophysical sensors. Seismological Data Centers operate the servers thereby allowing a variety of client applications to directly access the information at these data centers. Currently IRIS, the U. of South Carolina, UC Berkeley, and a European Data Center (ORFEUS) have been involved in the DHI project. This talk will highlight some of the DHI enabled clients that allow geophysical information to be directly transferred to the clients. Since the data center servers appear with the same interface specification (Interface Definition Language) a client that can talk to one DHI server can talk to any DHI enabled

  6. Current standards of neuropsychological assessment in epilepsy surgery centers across Europe.

    PubMed

    Vogt, Viola Lara; Äikiä, Marja; Del Barrio, Antonio; Boon, Paul; Borbély, Csaba; Bran, Ema; Braun, Kees; Carette, Evelien; Clark, Maria; Cross, Judith Helen; Dimova, Petia; Fabo, Daniel; Foroglou, Nikolaos; Francione, Stefano; Gersamia, Anna; Gil-Nagel, Antonio; Guekht, Alla; Harrison, Sue; Hecimovic, Hrvoje; Heminghyt, Einar; Hirsch, Edouard; Javurkova, Alena; Kälviäinen, Reetta; Kavan, Nicole; Kelemen, Anna; Kimiskidis, Vasilios K; Kirschner, Margarita; Kleitz, Catherine; Kobulashvili, Teia; Kosmidis, Mary H; Kurtish, Selin Yagci; Lesourd, Mathieu; Ljunggren, Sofia; Lossius, Morten Ingvar; Malmgren, Kristina; Mameniskiené, Ruta; Martin-Sanfilippo, Patricia; Marusic, Petr; Miatton, Marijke; Özkara, Çiğdem; Pelle, Federica; Rubboli, Guido; Rudebeck, Sarah; Ryvlin, Philippe; van Schooneveld, Monique; Schmid, Elisabeth; Schmidt, Pia-Magdalena; Seeck, Margitta; Steinhoff, Bernhard J; Shavel-Jessop, Sara; Tarta-Arsene, Oana; Trinka, Eugen; Viggedal, Gerd; Wendling, Anne-Sophie; Witt, Juri-Alexander; Helmstaedter, Christoph

    2017-03-01

    We explored the current practice with respect to the neuropsychological assessment of surgical epilepsy patients in European epilepsy centers, with the aim of harmonizing and establishing common standards. Twenty-six epilepsy centers and members of "E-PILEPSY" (a European pilot network of reference centers in refractory epilepsy and epilepsy surgery), were asked to report the status of neuropsychological assessment in adults and children via two different surveys. There was a consensus among these centers regarding the role of neuropsychology in the presurgical workup. Strong agreement was found on indications (localization, epileptic dysfunctions, adverse drugs effects, and postoperative monitoring) and the domains to be evaluated (memory, attention, executive functions, language, visuospatial skills, intelligence, depression, anxiety, and quality of life). Although 186 different tests are in use throughout these European centers, a core group of tests reflecting a moderate level of agreement could be discerned. Variability exists with regard to indications, protocols, and paradigms for the assessment of hemispheric language dominance. For the tests in use, little published evidence of clinical validity in epilepsy was provided. Participants in the survey reported a need for improvement concerning the validity of the tests, tools for the assessment of everyday functioning and accelerated forgetting, national norms, and test co-normalization. Based on the present survey, we documented a consensus regarding the indications and principles of neuropsychological testing. Despite the variety of tests in use, the survey indicated that there may be a core set of tests chosen based on experience, as well as on published evidence. By combining these findings with the results of an ongoing systematic literature review, we aim for a battery that can be recommended for the use across epilepsy surgical centers in Europe.

  7. Implementing a perpetual anesthesia setup standardized for the trauma room in a level I trauma center.

    PubMed

    Faircloth, Amanda C; Ford, Mary B

    2013-02-01

    The trauma room in a level I trauma center is a dynamic environment that provides little room for error. Significant variability can exist if anesthesia providers set up the room differently. Standardization provides a system that is consistent, reliable, and cost-effective. This study examines the process of creating and implementing a standardized anesthesia setup in the trauma room of a level I trauma center. As a result of this study, the medication cart and airway setups have been standardized. Providers are encouraged to only draw up medications that will be immediately used and to ensure that prefilled syringes have been incorporated into the pharmacy formulary. Using the EZ Endo prestyleted endotracheal tube (ETT) vs a regular ETT with stylet has yielded an annual cost savings of $2,673. Ensuring that items such as an esophageal temperature probe, humidifier, and nasogastric tube are available but unopened has provided a savings of $1,989.25 per year. The reservoir bag has been changed to a latex-free bag, and 3 central line kits including an arterial line kit are routinely stocked. An ultrasound machine dedicated for central line access, GlideScope, rapid fluid infuser, and Airtraq laryngoscope have all been incorporated into the permanent setup in the trauma room.

  8. Standard laboratory tests to identify older adults at increased risk of death.

    PubMed

    Howlett, Susan E; Rockwood, Michael R H; Mitnitski, Arnold; Rockwood, Kenneth

    2014-10-07

    Older adults are at an increased risk of death, but not all people of the same age have the same risk. Many methods identify frail people (that is, those at increased risk) but these often require time-consuming interactions with health care providers. We evaluated whether standard laboratory tests on their own, or added to a clinical frailty index (FI), could improve identification of older adults at increased risk of death. This is a secondary analysis of a prospective cohort study, where community dwelling and institutionalized participants in the Canadian Study of Health and Aging who also volunteered for blood collection (n = 1,013) were followed for up to six years. A standard FI (FI-CSHA) was constructed from data obtained during the clinical evaluation and a second, novel FI was constructed from laboratory data plus systolic and diastolic blood pressure measurements (FI-LAB). A combined FI included all items from each index. Predictive validity was tested using Cox proportional hazards analysis and discriminative ability by the area under receiver operating characteristic (ROC) curves. Of 1,013 participants, 51.3% had died by six years. The mean baseline value of the FI-LAB was 0.27 (standard deviation 0.11; range 0.05 to 0.63), the FI-CSHA was 0.25 (0.11; 0.02 to 0.72), and the combined FI was 0.26 (0.09; 0.06 to 0.59). In an age- and sex-adjusted model, with each increment in the FI-LAB, the hazard ratios increased by 2.8% (95% confidence interval 1.02 to 1.04). The hazard ratios for the FI-CSHA and the combined FI were 1.02 (1.01 to 1.03) and 1.04 (1.03 to 1.05), respectively. The FI-LAB and FI-CSHA remained independently associated with death in the face of the other. The areas under the ROC curves were 0.72 for FI-LAB, 0.73 for FI-CSHA and 0.74 for the combined FI. An FI based on routine laboratory data can identify older adults at increased risk of death. Additional evaluation of this approach in clinical settings is warranted.

  9. Exposure to hazardous substances in a standard molecular biology laboratory environment: evaluation of exposures in IARC laboratories.

    PubMed

    Chapot, Brigitte; Secretan, Béatrice; Robert, Annie; Hainaut, Pierre

    2009-07-01

    Working in a molecular biology laboratory environment implies regular exposure to a wide range of hazardous substances. Several recent studies have shown that laboratory workers may have an elevated risk of certain cancers. Data on the nature and frequency of exposures in such settings are scanty. The frequency of use of 163 agents by staff working in molecular biology laboratories was evaluated over a period of 4 years by self-administered questionnaire. Of the agents listed, ethanol was used by the largest proportion of staff (70%), followed by ethidium bromide (55%). Individual patterns of use showed three patterns, namely (i) frequent use of a narrow range of products, (ii) occasional use of a wide range of products, and (iii) frequent and occasional use of an intermediate range of products. Among known or suspected carcinogens (International Agency for Research on Cancer Group 1 and 2A, respectively), those most frequently used included formaldehyde (17%), oncogenic viruses (4%), and acrylamide (32%). The type of exposure encountered in research laboratories is extremely diverse. Few carcinogenic agents are used frequently but many laboratory workers may be exposed occasionally to known human carcinogens. In addition, many of the chemicals handled by staff represent a health hazard. The results enabled the staff physician to develop an individual approach to medical surveillance and to draw a personal history of occupational exposures for laboratory staff.

  10. Large space antenna communications systems: Integrated Langley Research Center/Jet Propulsion Laboratory development activities. 2: Langley Research Center activities

    NASA Technical Reports Server (NTRS)

    Cambell, T. G.; Bailey, M. C.; Cockrell, C. R.; Beck, F. B.

    1983-01-01

    The electromagnetic analysis activities at the Langley Research Center are resulting in efficient and accurate analytical methods for predicting both far- and near-field radiation characteristics of large offset multiple-beam multiple-aperture mesh reflector antennas. The utilization of aperture integration augmented with Geometrical Theory of Diffraction in analyzing the large reflector antenna system is emphasized.

  11. Tu-144LL SST Flying Laboratory on Taxiway at Zhukovsky Air Development Center near Moscow, Russia

    NASA Technical Reports Server (NTRS)

    1998-01-01

    The sleek lines of the Tupolev Tu-144LL are evident as it sits on the taxiway at the Zhukovsky Air Development Center near Moscow, Russia. NASA teamed with American and Russian aerospace industries for an extended period in a joint international research program featuring the Russian-built Tu-144LL supersonic aircraft. The object of the program was to develop technologies for a proposed future second-generation supersonic airliner to be developed in the 21st Century. The aircraft's initial flight phase began in June 1996 and concluded in February 1998 after 19 research flights. A shorter follow-on program involving seven flights began in September 1998 and concluded in April 1999. All flights were conducted in Russia from Tupolev's facility at the Zhukovsky Air Development Center near Moscow. The centerpiece of the research program was the Tu 144LL, a first-generation Russian supersonic jetliner that was modified by its developer/builder, Tupolev ANTK (aviatsionnyy nauchno-tekhnicheskiy kompleks-roughly, aviation technical complex), into a flying laboratory for supersonic research. Using the Tu-144LL to conduct flight research experiments, researchers compared full-scale supersonic aircraft flight data with results from models in wind tunnels, computer-aided techniques, and other flight tests. The experiments provided unique aerodynamic, structures, acoustics, and operating environment data on supersonic passenger aircraft. Data collected from the research program was being used to develop the technology base for a proposed future American-built supersonic jetliner. Although actual development of such an advanced supersonic transport (SST) is currently on hold, commercial aviation experts estimate that a market for up to 500 such aircraft could develop by the third decade of the 21st Century. The Tu-144LL used in the NASA-sponsored research program was a 'D' model with different engines than were used in production-model aircraft. Fifty experiments were proposed

  12. Tu-144LL SST Flying Laboratory on Taxiway at Zhukovsky Air Development Center near Moscow, Russia

    NASA Technical Reports Server (NTRS)

    1998-01-01

    The sleek lines of the Tupolev Tu-144LL are evident as it sits on the taxiway at the Zhukovsky Air Development Center near Moscow, Russia. NASA teamed with American and Russian aerospace industries for an extended period in a joint international research program featuring the Russian-built Tu-144LL supersonic aircraft. The object of the program was to develop technologies for a proposed future second-generation supersonic airliner to be developed in the 21st Century. The aircraft's initial flight phase began in June 1996 and concluded in February 1998 after 19 research flights. A shorter follow-on program involving seven flights began in September 1998 and concluded in April 1999. All flights were conducted in Russia from Tupolev's facility at the Zhukovsky Air Development Center near Moscow. The centerpiece of the research program was the Tu 144LL, a first-generation Russian supersonic jetliner that was modified by its developer/builder, Tupolev ANTK (aviatsionnyy nauchno-tekhnicheskiy kompleks-roughly, aviation technical complex), into a flying laboratory for supersonic research. Using the Tu-144LL to conduct flight research experiments, researchers compared full-scale supersonic aircraft flight data with results from models in wind tunnels, computer-aided techniques, and other flight tests. The experiments provided unique aerodynamic, structures, acoustics, and operating environment data on supersonic passenger aircraft. Data collected from the research program was being used to develop the technology base for a proposed future American-built supersonic jetliner. Although actual development of such an advanced supersonic transport (SST) is currently on hold, commercial aviation experts estimate that a market for up to 500 such aircraft could develop by the third decade of the 21st Century. The Tu-144LL used in the NASA-sponsored research program was a 'D' model with different engines than were used in production-model aircraft. Fifty experiments were proposed

  13. Creating Better Child Care Jobs: Model Work Standards for Teaching Staff in Center-Based Child Care.

    ERIC Educational Resources Information Center

    Center for the Child Care Workforce, Washington, DC.

    This document presents model work standards articulating components of the child care center-based work environment that enable teachers to do their jobs well. These standards establish criteria to assess child care work environments and identify areas to improve in order to assure good jobs for adults and good care for children. The standards are…

  14. Creating Better Child Care Jobs: Model Work Standards for Teaching Staff in Center-Based Child Care.

    ERIC Educational Resources Information Center

    Center for the Child Care Workforce, Washington, DC.

    This document presents model work standards articulating components of the child care center-based work environment that enable teachers to do their jobs well. These standards establish criteria to assess child care work environments and identify areas to improve in order to assure good jobs for adults and good care for children. The standards are…

  15. Hyperimmune antirabies sera titration by standard mouse neutralization and counterimmunoelectrophoresis tests, comparing results of different laboratories.

    PubMed

    Díaz, A M; Valentini, E J; Albas, A; Fuches, R M; Gallina, N M

    1995-01-01

    To determine the rabies antibody level of twenty-four hyperimmune equine sera, Standard Mouse Neutralization (SMN) and Couterimmunoelectrophoresis (CIE) tests were carried out, both at the Instituto Butantan (IB) and Instituto Panamericano de Proteccíon de Alimentos y Zoonosis (INPPAZ). Statistical analysis has shown a correlation (r) of 0.9317 between the SMN and CIE performed at the IB, while at the INPPAZ it scored 0.974. Comparison of CIE data of both laboratories yielded a correlation of 0.845. The CIE technique has shown to be a sensitive and efficient as the SMN in titrating antirabies hyperimmune equine sera. Based on CIE results, a simple, rapid and inexpensive technique, titers of sera antibody can be rellably estimated in SMN test.

  16. Clinical laboratories. Profit center, production industry or patient-care resource?

    PubMed

    Conn, R B

    1978-02-23

    The clinical laboratory is an essential component of the medical-care system. Rapidly increasing expenditures for laboratory services, fraudulent practices and reports of laboratory error are precipitating legislative and regulatory actions that will affect clinical laboratories and how they are used by physicians in caring for their patients. Many problems related to clinical laboratories are due to the rapid introduction of new technologies, to methods of educating medical students and house officers, to the rapidly expanding scientific base of medicine and to economic factors that have subordinated medical and scientific objectives in the laboratory to economic ones. Implementation of existing legislation would settle many of the economic issues, but more effective integration of the clinical laboratory into the patient-care process and better methods for educating medical students in the use of laboratory information are critical tasks for the medical profession.

  17. Standard Hydrogen Test Protocols for the NREL Sensor Testing Laboratory (Brochure)

    SciTech Connect

    Not Available

    2011-12-01

    This brochure summarizes the test protocols used in the NREL Hydrogen Sensor Test Laboratory for the quantitative assessment of critical analytical performance specifications for hydrogen sensors. Researchers at the NREL Hydrogen Safety Sensor Test Laboratory developed a variety of test protocols to quantitatively assess critical analytical performance specifications for hydrogen sensors. Many are similar to, but typically more rigorous than, the test procedures mandated by ISO Standard 26142 (Hydrogen Detector for Stationary Applications). Specific protocols were developed for linear range, short-term stability, and the impact of fluctuations in temperature (T), pressure (P), relative humidity (RH), and chemical environment. Specialized tests (e.g., oxygen requirement) may also be performed. Hydrogen safety sensors selected for evaluation are subjected to a thorough regimen of test protocols, as described. Sensor testing is performed at NREL on custom-built sensor test fixtures. Environmental parameters such as T, P, RH, and gas composition are rigorously controlled and monitored. The NREL evaluations are performed on commercial hydrogen detectors, on emerging sensing technologies, and for end users to validate sensor performance for specific application needs. Test results and data are shared with the manufacturer or client via summary reports, teleconference phone calls, and, when appropriate, site visits to manufacturer facilities. Client representatives may also monitor NREL's operation while their technologies are being tested. Manufacturers may use test data to illustrate the analytical capability of their technologies and, more importantly, to guide future developments. NREL uses the data to assess technology gaps and deployment considerations. Per NREL Sensor Testing Laboratory policy, test results are treated as proprietary and are not shared with other manufacturers or other entities without permission. The data may be used by NREL in open publications

  18. Rain simulator as a standardized laboratory measurement of soil structural stability

    NASA Astrophysics Data System (ADS)

    Iglesias, Luz; Cancelo González, Javier; Benito, Elena; Álvarez, Manuel; Barral, Maria Teresa; Díaz-Fierros, Francisco

    2010-05-01

    Rainfall simulations are used since the 30's by scientist and technicians to study the soil erosion and soil hydrology. The basis of the rainfall simulation is that can reproduce the natural soil degradation processes, more accurately than the traditional methods used for the determination of structural stability. A rainfall simulator was built in 2006 based on those made by Guitián and Méndez (1961), and Morin (1967), to obtain standardized laboratory measurements of soil structural stability and a final implementation were made in the rainfall simulator to incorporate a intermittent fan-like water yet system with four sieves of 250 micrometres where the soil samples can be placed, and allow the simultaneous measurement of soil losses in the samples. Data obtained in the rainfall simulator, using different soils of the study basins, are related with the Ig Henin index and the results of the Emerson structural stability test. At the same time with the laboratory test, 10 water sampling surveys were carried out during the hydrological years 2004/05 and 2005/06, in two basins located in the humid region of NW Spain belonging to the Anllons River basin, one of the main basins of Galicia-Costa, that has been subject of detailed hydrological studies since 2000 (Rial, M., 2007 and Devesa, R., 2009) and had continuous records of streamflow. The selected subbasins have 57,62 and 50,05 square kilometres respectively, and presents significative geological differences; being one of them formed, mainly, by schists and a lower area with granites and, the other one formed mainly by gabbros. The suspended sediments in the samples were separated by centrifugation and weighted in the laboratory to study the possible relationship between soil losses in the rainfall simulations and the sediment fluxes in the river. The analysis revealed a good relationship between the sediments delivery to the streams and soil losses measured in the rainfall simulations.

  19. 76 FR 38550 - Technical Standard DOE-STD-1095-2011, Department of Energy Laboratory Accreditation for External...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-01

    ...The Department of Energy (DOE or the Department) is issuing Technical Standard DOE-STD-1095-2011, Department of Energy Laboratory Accreditation for External Dosimetry, January 2011. This standard provides updated technical criteria for performance testing for, and provides a requirement for onsite quality assurance assessments of, whole body and extremity dosimetry programs in use at DOE......

  20. ISO 18812--a worldwide standard for the online-connection of analytical instruments to laboratory information systems.

    PubMed

    Fraterman, Arno

    2004-01-01

    In the past there were many attempts to standardize the interface from analytical instruments to laboratory-information-systems. Most of these attempts were national. The international standardisation bodies CEN and ISO have now developed an international standard that is presented here.

  1. Toward an interim standard for patient-centered knowledge-access.

    PubMed Central

    Tuttle, M. S.; Sherertz, D. D.; Fagan, L. M.; Carlson, R. W.; Cole, W. G.; Schipma, P. B.; Nelson, S. J.

    1993-01-01

    Most care-giver "knowledge" needs arise at the point of care and are "patient-centered." Many of these knowledge needs can be met using existing on-line knowledge sources, but the process is too time-consuming, currently, for even the computer-proficient. We are developing a set of public domain standards aimed at bringing potentially relevant knowledge to the point of care in a straight-forward and timely fashion. The standards will a) make use of selected items from a Computer-based Patient Record (CPR), e.g., a diagnosis and measure of severity, b) anticipate certain care-giver knowledge needs, e.g., "therapy," "protocols," "complications," and c) try to satisfy those needs from available knowledge sources, e.g., knowledge-bases, citation databases, practice guidelines, and on-line textbooks. The standards will use templates, i.e., fill-in-the-blank structures, to anticipate knowledge needs and UMLS Metathesaurus enhancements to represent the content of knowledge sources. Together, the standards will form the specification for a "Knowledge-Server" (KS) designed to be accessed from any CPR system. Plans are in place to test an interim version of this specification in the context of medical oncology. We are accumulating anecdotal evidence that a KS operating in conjunction with a CPR is much more compelling to users than either a CPR or a KS operating alone. PMID:8130537

  2. Blood Cholesterol Measurement in Clinical Laboratories in the United States. Current Status. A Report from the Laboratory Standardization Panel of the National Cholesterol Education Program.

    ERIC Educational Resources Information Center

    National Heart, Lung, and Blood Inst. (DHHS/NIH), Bethesda, MD.

    Precise and accurate cholesterol measurements are required to identify and treat individuals with high blood cholesterol levels. However, the current state of reliability of blood cholesterol measurements suggests that considerable inaccuracy in cholesterol testing exists. This report describes the Laboratory Standardization Panel findings on the…

  3. Good clinical laboratory practices improved proficiency testing performance at clinical trials centers in Ghana and Burkina Faso.

    PubMed

    Ibrahim, Faisal; Dosoo, David; Kronmann, Karl C; Ouedraogo, Issa; Anyorigiya, Thomas; Abdul, Haruna; Sodiomon, Sirima; Owusu-Agyei, Seth; Koram, Kwadwo

    2012-01-01

    The recent drive towards accreditation of clinical laboratories in Africa by the World Health Organization-Regional Office for Africa (WHO-AFRO) and the U.S Government is a historic step to strengthen health systems, provide better results for patients and an improved quality of results for clinical trials. Enrollment in approved proficiency testing (PT) programs and maintenance of satisfactory performance is vital in the process of accreditation. Passing proficiency testing surveys has posed a great challenge to many laboratories across sub-Saharan Africa. Our study was aimed at identifying the causes of unsatisfactory PT results in clinical research laboratories conducting or planning to conduct malaria vaccine trials sponsored by the National Institutes of Health (NIH). PT reports for 2009 and 2010 from the College of American Pathologists (CAP) for the laboratories were reviewed as part of the process. Errors accounting for unsatisfactory results were classified into clerical, methodological, technical, problem with PT materials, and random errors. A training program on good clinical laboratory practices (GCLP) was developed for each center to address areas for improvement. The major cause of PT failure in the four centers was methodological. The application of GCLP improved the success rate in the PT surveys from 58% in 2009 to 88% in 2010. It also decreased the error rate on PT by 35%. A previous report from the CAP- PT participating laboratories indicated that the major causes of error were clerical. These types of errors were predominantly made in laboratories in the US, with much more experience in quality control, and varied significantly from what we found. In our centers in sub-Saharan Africa, methodological errors, and not clerical errors, accounted for the vast majority of errors. A process was started for continuous improvement which has decreased methodological errors by 35%, but more improvement is needed.

  4. Good Clinical Laboratory Practices Improved Proficiency Testing Performance at Clinical Trials Centers in Ghana and Burkina Faso

    PubMed Central

    Ibrahim, Faisal; Dosoo, David; Kronmann, Karl C.; Ouedraogo, Issa; Anyorigiya, Thomas; Abdul, Haruna; Sodiomon, Sirima; Owusu-Agyei, Seth; Koram, Kwadwo

    2012-01-01

    Background The recent drive towards accreditation of clinical laboratories in Africa by the World Health Organization – Regional Office for Africa (WHO-AFRO) and the U.S Government is a historic step to strengthen health systems, provide better results for patients and an improved quality of results for clinical trials. Enrollment in approved proficiency testing (PT) programs and maintenance of satisfactory performance is vital in the process of accreditation. Passing proficiency testing surveys has posed a great challenge to many laboratories across sub-Saharan Africa. Our study was aimed at identifying the causes of unsatisfactory PT results in clinical research laboratories conducting or planning to conduct malaria vaccine trials sponsored by the National Institutes of Health (NIH). Methodology PT reports for 2009 and 2010 from the College of American Pathologists (CAP) for the laboratories were reviewed as part of the process. Errors accounting for unsatisfactory results were classified into clerical, methodological, technical, problem with PT materials, and random errors. A training program on good clinical laboratory practices (GCLP) was developed for each center to address areas for improvement. Results The major cause of PT failure in the four centers was methodological. The application of GCLP improved the success rate in the PT surveys from 58% in 2009 to 88% in 2010. It also decreased the error rate on PT by 35%. Conclusion A previous report from the CAP- PT participating laboratories indicated that the major causes of error were clerical. These types of errors were predominantly made in laboratories in the US, with much more experience in quality control, and varied significantly from what we found. In our centers in sub-Saharan Africa, methodological errors, and not clerical errors, accounted for the vast majority of errors. A process was started for continuous improvement which has decreased methodological errors by 35%, but more improvement is

  5. Sandia National Laboratories Facilities Management and Operations Center Design Standards Manual

    SciTech Connect

    Fattor, Steven

    2014-06-01

    The manual contains general requirements that apply to nonnuclear and nonexplosive facilities. For design and construction requirements for modifications to nuclear or explosive facilities, see the project-specific design requirements noted in the Design Criteria.

  6. Ethical and methodological standards for laboratory and medical biological rhythm research.

    PubMed

    Portaluppi, Francesco; Touitou, Yvan; Smolensky, Michael H

    2008-11-01

    The main objectives of this article are to update the ethical standards for the conduct of human and animal biological rhythm research and recommend essential elements for quality chronobiological research information, which should be especially useful for new investigators of the rhythms of life. A secondary objective is to provide for those with an interest in the results of chronobiology investigations, but who might be unfamiliar with the field, an introduction to the basic methods and standards of biological rhythm research and time series data analysis. The journal and its editors endorse compliance of all investigators to the principles of the Declaration of Helsinki of the World Medical Association, which relate to the conduct of ethical research on human beings, and the Guide for the Care and Use of Laboratory Animals of the Institute for Laboratory Animal Research of the National Research Council, which relate to the conduct of ethical research on laboratory and other animals. The editors and the readers of the journal expect the authors of submitted manuscripts to have adhered to the ethical standards dictated by local, national, and international laws and regulations in the conduct of investigations and to be unbiased and accurate in reporting never-before-published research findings. Authors of scientific papers are required to disclose all potential conflicts of interest, particularly when the research is funded in part or in full by the medical and pharmaceutical industry, when the authors are stock-holders of the company that manufactures or markets the products under study, or when the authors are a recent or current paid consultant to the involved company. It is the responsibility of the authors of submitted manuscripts to clearly present sufficient detail about the synchronizer schedule of the studied subjects (i.e., the sleep-wake schedule, ambient light-dark cycle, intensity and spectrum of ambient light exposure, seasons when the research was

  7. Effects of Spectral Transmittance through Standard Laboratory Cages on Circadian Metabolism and Physiology in Nude Rats

    PubMed Central

    Dauchy, Robert T; Dauchy, Erin M; Hanifin, John P; Gauthreaux, Sheena L; Mao, Lulu; Belancio, Victoria P; Ooms, Tara G; Dupepe, Lynell M; Jablonski, Michael R; Warfield, Benjamin; Wren, Melissa A; Brainard, George C; Hill, Steven M; Blask, David E

    2013-01-01

    Light is potent in circadian, neuroendocrine, and neurobehavioral regulation, thereby having profound influence on the health and wellbeing of all mammals, including laboratory animals. We hypothesized that the spectral quality of light transmitted through colored compared with clear standard rodent cages alters circadian production of melatonin and temporal coordination of normal metabolic and physiologic activities. Female nude rats (Hsd:RH-Foxn1rnu; n = 6 per group) were maintained on a 12:12-h light:dark regimen (300 lx; lights on, 0600) in standard translucent clear, amber, or blue rodent cages; intensity and duration of lighting were identical for all groups. Rats were assessed for arterial blood levels of pO2 and pCO2, melatonin, total fatty acid, glucose, lactic acid, insulin, leptin, and corticosterone concentrations at 6 circadian time points. Normal circadian rhythms of arterial blood pO2 and pCO2 were different in rats housed in cages that were blue compared with amber or clear. Plasma melatonin levels (mean ± 1 SD) were low (1.0 ± 0.2 pg/mL) during the light phase in all groups but higher at nighttime in rats in blue cages (928.2 ± 39.5 pg/mL) compared with amber (256.8 ± 6.6 pg/mL) and clear (154.8 ± 9.3 pg/mL) cages. Plasma daily rhythms of total fatty acid, glucose, lactic acid, leptin, insulin, and corticosterone were disrupted in rats housed in blue or amber compared with clear cages. Temporal coordination of circadian rhythms of physiology and metabolism can be altered markedly by changes in the spectral quality of light transmitted through colored standard rodent cages. PMID:23562097

  8. 76 FR 5379 - Clinical Laboratory Improvement Advisory Committee (CLIAC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-31

    ..., revisions to the standards under which clinical laboratories are regulated; the impact on medical and... Clinical Laboratory Workforce; the National Institutes of Health Genetic Test Registry design and responses... HUMAN SERVICES Centers for Disease Control and Prevention Clinical Laboratory Improvement...

  9. Open standards for cascade models for RHIC: Volume 1. Proceedings of RIKEN BNL Research Center workshop

    SciTech Connect

    1997-10-01

    It is widely recognized that cascade models are potentially effective and powerful tools for interpreting and predicting multi-particle observables in heavy ion physics. However, the lack of common standards, documentation, version control, and accessibility have made it difficult to apply objective scientific criteria for evaluating the many physical and algorithmic assumptions or even to reproduce some published results. The first RIKEN Research Center workshop was proposed by Yang Pang to address this problem by establishing open standards for original codes for applications to nuclear collisions at RHIC energies. The aim of this first workshop is: (1) to prepare a WWW depository site for original source codes and detailed documentation with examples; (2) to develop and perform standardized test for the models such as Lorentz invariance, kinetic theory comparisons, and thermodynamic simulations; (3) to publish a compilation of results of the above work in a journal e.g., ``Heavy Ion Physics``; and (4) to establish a policy statement on a set of minimal requirements for inclusion in the OSCAR-WWW depository.

  10. Awareness of the National Standards for Culturally and Linguistically Appropriate Services at an academic health center.

    PubMed

    Carrillo-Zuniga, Genny; Dadig, Bonnie; Guion, Kent W; Rice, Vivian I

    2008-01-01

    The study's objectives were to (a) determine the level of familiarity of faculty and students at an academic health center with the National Standards for Culturally and Linguistically Appropriate Services (CLAS), (b) identify faculty's and students' interest and preferred method of learning Medical Spanish, and (c) determine their aptitude for working with medical interpreters. A survey was developed, piloted, and sent via e-mail to all faculty members (n = 1,025) and students (n = 1,956) currently affiliated with or enrolled at the Medical College of Georgia. Reminder e-mails were sent after 2 weeks, and responses were accepted for 1 month. The total response rate for faculty members was 29% (300/1,025), and that for students was 44% (871/1,956). Nearly 22% of the responding faculty and 23% of the responding students reported that they were less than familiar with the National Standards for CLAS. Both faculty (46%) and students (70%) were willing to spend time learning Medical Spanish. Web-based instruction was the preferred educational delivery mode for those who completed the survey; however, 18% of faculty and 5% of students strongly disagreed with this point. When questioned about how often interpreters services are used, the rates for faculty and students ranged from 34% to 39%. These results suggest that a void exists in understanding the National Standards for CLAS and that there are varying levels of willingness to learn medical Spanish.

  11. Data Format Standardization of Space Weather Model Output at the Community Coordinated Modeling Center

    NASA Technical Reports Server (NTRS)

    Maddox, M.; Rastatter, L.; Hesse, M.

    2005-01-01

    The disparate nature of space weather model output provides many challenges with regards to the portability and reuse of not only the data itself, but also any tools that are developed for analysis and visualization. We are developing and implementing a comprehensive data format standardization methodology that allows heterogeneous model output data to be stored uniformly in any common science data format. We will discuss our approach to identifying core meta-data elements that can be used to supplement raw model output data, thus creating self-descriptive files. The meta-data should also contain information describing the simulation grid. This will ultimately assists in the development of efficient data access tools capable of extracting data at any given point and time. We will also discuss our experiences standardizing the output of two global magnetospheric models, and how we plan to apply similar procedures when standardizing the output of the solar, heliospheric, and ionospheric models that are also currently hosted at the Community Coordinated Modeling Center.

  12. Uniform Labeling of Blocks and Slides in Surgical Pathology: Guideline From the College of American Pathologists Pathology and Laboratory Quality Center and the National Society for Histotechnology.

    PubMed

    Brown, Richard W; Della Speranza, Vincent; Alvarez, Janice O; Eisen, Richard N; Frishberg, David P; Rosai, Juan; Santiago, Jerry; Tunnicliffe, Janet; Colasacco, Carol; Lacchetti, Christina; Thomas, Nicole E

    2015-12-01

    The labeling of paraffin blocks and microscopic glass slides in the practice of surgical pathology varies from institution to institution and introduces potential risk of preanalytic error. Currently there are no evidence-based guidelines regarding the uniform labeling of these materials. To develop recommendations that will address the need for adequate patient identification and provide a consistent method of identifying slides originating from a particular block. - The College of American Pathologists Pathology and Laboratory Quality Center and the National Society for Histotechnology convened a panel of pathologists and histotechnologists with expertise in histology laboratory quality practices to develop labeling recommendations. A systematic evidence review was conducted to address 6 main key questions. Recommendations were derived from strength of evidence, open comment feedback, and expert panel consensus. Twelve guideline statements were established to assist pathology laboratories in developing standardized block and slide labeling practices. These guidelines call for the use of 2 patient identifiers, 1 of which includes the accession number and case type, on all paraffin blocks and slides. Recommendations were also developed to address the order and format in which identifying elements should appear. Uniform labeling of paraffin blocks and slides derived from patient specimens will provide an important enhancement to patient safety by assuring that all preparations derived from a patient's tissue can be uniquely and unambiguously linked to that patient. Adoption of standardized practices additionally will improve patient care by facilitating interpretation of histologic sections when they are referred in consultation to a second institution.

  13. Laparoscopic skills laboratories: current assessment and a call for resident training standards.

    PubMed

    Korndorffer, James R; Stefanidis, Dimitris; Scott, Daniel J

    2006-01-01

    Numerous protocols for laparoscopic skills training using simulator-based laboratories have proven effective. However, little is known about the availability and uniformity of such facilities. The purpose of this study was to evaluate the prevalence, utilization, and costs of skills laboratories currently in use. A survey was mailed to 253 general surgery program directors to determine the perceived value, prevalence, equipment, types of training, supervision, and costs of the labs. One hundred sixty-two (64%) programs completed the survey. Eighty-eight percent of responders consider skills labs effective in improving operating room performance; however, only 55% have skills labs. Of 89 programs with skills labs, 99% have videotrainer equipment (mean 3.8 trainers per lab, range 1 to 15); 46% have virtual reality trainer equipment (mean 1.7 trainers per lab, range 1 to 7). Eighty-two percent of programs teach basic skills using a variety of tasks (Rosser/Southwestern stations, MIST-VR, MISTELS, department-created); 96% teach suturing (intracorporeal, extracorporeal, suture devices). On average, residents train 0.8 hours per week (range 0 to 6). Training is mandatory in 55% and supervised in 73% of the programs. The mean development cost was 133,000 dollars (range 300 dollars to 1,000,000 dollars). While a large majority of program directors consider skills labs important, 45% of programs have no such facilities. Moreover, significant variability of equipment and training practices exist in currently available labs. Strategies are needed for more widespread implementation of skills labs, and standards should be developed to facilitate uniform adoption of validated curricula that reliably maximize training efficiency and educational benefit.

  14. Nidus Center for Scientific Enterprise, St. Louis, Missouri; Laboratories for the 21st Century: Case Studies (Revised)

    SciTech Connect

    Not Available

    2005-03-01

    This publication is one in an ongoing series of case studies for "Laboratories for the 21st Century," a joint program of the U.S. Environmental Protection Agency and the U.S. Department of Energy Federal Energy Management Program. It is intended for all those who plan, design, and construct public and private-sector laboratory buildings. This study describes how the Nidus Center, a nonprofit incubator for life sciences and plan biotechnology established by Monsanto Company, employs daylighting, an energy-efficient mechanical system featuring energy recovery, and water conservation practices, among others, to save energy and money and help conserve natural resources.

  15. The Astromaterials X-Ray Computed Tomography Laboratory at Johnson Space Center

    NASA Technical Reports Server (NTRS)

    Zeigler, R. A.; Coleff, D. M.; McCubbin, F. M.

    2017-01-01

    The Astromaterials Acquisition and Curation Office at NASA's Johnson Space Center (hereafter JSC curation) is the past, present, and future home of all of NASA's astromaterials sample collections. JSC curation currently houses all or part of nine different sample collections: (1) Apollo samples (1969), (2) Lunar samples (1972), (3) Antarctic meteorites (1976), (4) Cosmic Dust particles (1981), (5) Microparticle Impact Collection (1985), (6) Genesis solar wind atoms (2004); (7) Stardust comet Wild-2 particles (2006), (8) Stardust interstellar particles (2006), and (9) Hayabusa asteroid Itokawa particles (2010). Each sample collection is housed in a dedicated clean room, or suite of clean rooms, that is tailored to the requirements of that sample collection. Our primary goals are to maintain the long-term integrity of the samples and ensure that the samples are distributed for scientific study in a fair, timely, and responsible manner, thus maximizing the return on each sample. Part of the curation process is planning for the future, and we also perform fundamental research in advanced curation initiatives. Advanced Curation is tasked with developing procedures, technology, and data sets necessary for curating new types of sample collections, or getting new results from existing sample collections [2]. We are (and have been) planning for future curation, including cold curation, extended curation of ices and volatiles, curation of samples with special chemical considerations such as perchlorate-rich samples, and curation of organically- and biologically-sensitive samples. As part of these advanced curation efforts we are augmenting our analytical facilities as well. A micro X-Ray computed tomography (micro-XCT) laboratory dedicated to the study of astromaterials will be coming online this spring within the JSC Curation office, and we plan to add additional facilities that will enable nondestructive (or minimally-destructive) analyses of astromaterials in the near

  16. The Astromaterials X-Ray Computed Tomography Laboratory at Johnson Space Center

    NASA Technical Reports Server (NTRS)

    Zeigler, R. A.; Coleff, D. M.; McCubbin, F. M.

    2017-01-01

    The Astromaterials Acquisition and Curation Office at NASA's Johnson Space Center (hereafter JSC curation) is the past, present, and future home of all of NASA's astromaterials sample collections. JSC curation currently houses all or part of nine different sample collections: (1) Apollo samples (1969), (2) Lunar samples (1972), (3) Antarctic meteorites (1976), (4) Cosmic Dust particles (1981), (5) Microparticle Impact Collection (1985), (6) Genesis solar wind atoms (2004); (7) Stardust comet Wild-2 particles (2006), (8) Stardust interstellar particles (2006), and (9) Hayabusa asteroid Itokawa particles (2010). Each sample collection is housed in a dedicated clean room, or suite of clean rooms, that is tailored to the requirements of that sample collection. Our primary goals are to maintain the long-term integrity of the samples and ensure that the samples are distributed for scientific study in a fair, timely, and responsible manner, thus maximizing the return on each sample. Part of the curation process is planning for the future, and we also perform fundamental research in advanced curation initiatives. Advanced Curation is tasked with developing procedures, technology, and data sets necessary for curating new types of sample collections, or getting new results from existing sample collections [2]. We are (and have been) planning for future curation, including cold curation, extended curation of ices and volatiles, curation of samples with special chemical considerations such as perchlorate-rich samples, and curation of organically- and biologically-sensitive samples. As part of these advanced curation efforts we are augmenting our analytical facilities as well. A micro X-Ray computed tomography (micro-XCT) laboratory dedicated to the study of astromaterials will be coming online this spring within the JSC Curation office, and we plan to add additional facilities that will enable nondestructive (or minimally-destructive) analyses of astromaterials in the near

  17. The Levels of Inquiry Matrix in developing written lesson plans for laboratory-centered science instruction

    NASA Astrophysics Data System (ADS)

    Smith, William Robert

    This study examines the effectiveness of a full-semester inservice program in reforming the lesson planning practices of science teachers. The Levels of Inquiry Matrix was used as a model of inquiry focused, laboratory centered science instruction throughout the inservice program. Effective planning is crucial to the development and execution of good instruction and the Levels of Inquiry Matrix may serve as a tool toward reaching this goal. Thirty practicing science teachers completed courses designed to reform their teaching toward a greater emphasis on inquiry. The inservice teachers completed a background survey and wrote three lesson plans. The first was prepared prior to course treatment, the second was prepared at mid-course, and the third was prepared as a final project. A set of "Guidelines for Using the Levels of Inquiry Matrix" was prepared to aid in the objective classification of the level of inquiry planned for in each written lesson plan. Also, a list of permutations of the Levels of Inquiry Matrix was developed in order to classify the level of inquiry demonstrated by written lesson plans that did not match a sequence of student and teacher responsibility found on the Levels of Inquiry Matrix. The study demonstrated that inservice teachers in one of the two courses significantly improved in ability to write lesson plans that reflect greater levels of inquiry as defined by the Levels of Inquiry Matrix. The inservice teachers, in both courses, believed that they were planning for higher levels of inquiry than they actually demonstrated through the written lesson plans. They also believed they were improving in their ability to write lesson plans that reflected higher levels of inquiry whether they actually achieved this or not. No correlation was found between the inservice teachers' years of experience teaching science, educational background, certification status and the level of inquiry demonstrated by the lesson plans. Finally, the Inquiry Lesson

  18. Oak Ridge National Laboratory`s (ORNL) ecological and physical science study center: A hands-on science program for K-12 students

    SciTech Connect

    Bradshaw, S.P.

    1994-12-31

    In our tenth year of educational service and outreach, Oak Ridge National Laboratory`s Ecological and Physical Science Study Center (EPSSC) provides hands-on, inquiry-based science activities for area students and teachers. Established in 1984, the EPSSC now hosts over 20,000 student visits. Designed to foster a positive attitude towards science, each unit includes activities which reinforce the science concept being explored. Outdoor science units provide field experience at the Department of Energy`s Oak Ridge National Environmental Research Park and outreach programs are offered on-site in area schools. Other programs are offered as extensions of the EPSSC core programs, including on-site student science camps, all-girl programs, outreach science camps, student competitions, teacher in-service presentations and teacher workshops.

  19. Laboratory test descriptions for bovine respiratory disease diagnosis and their strengths and weaknesses: Gold standards for diagnosis, do they exist?

    PubMed Central

    Fulton, Robert W.; Confer, Anthony W.

    2012-01-01

    The diagnosis of bovine respiratory diseases (BRD) poses significant challenges to the clinician as there are numerous infectious etiologies, operating singly or most often in combination. Clinical signs alone may not be diagnostic and the diagnostic laboratory is often used to assist the clinician. Recently many molecular-based tests have been taken from the research laboratory to the veterinary diagnostic laboratory. This review describes the “traditional tests” and several “molecular tests” and discusses the benefits and limitations of the tests and their interpretation. Clinicians should consult with their diagnostic laboratory regarding the interpretation of the test results. The rate of development and use of molecular diagnostic tests have outpaced validation, standardization, and standards for interpretation relative to their use in BRD diagnostics. PMID:23277642

  20. Defining a Minimum Set of Standardized Patient-centered Outcome Measures for Macular Degeneration.

    PubMed

    Rodrigues, Ian A; Sprinkhuizen, Sara M; Barthelmes, Daniel; Blumenkranz, Mark; Cheung, Gemmy; Haller, Julia; Johnston, Robert; Kim, Ramasamy; Klaver, Caroline; McKibbin, Martin; Ngah, Nor Fariza; Pershing, Suzann; Shankar, Dato; Tamura, Hiroshi; Tufail, Adnan; Weng, Christina Y; Westborg, Inger; Yelf, Catherine; Yoshimura, Nagahisa; Gillies, Mark C

    2016-08-01

    To define a minimum set of outcome measures for tracking, comparing, and improving macular degeneration care. Recommendations from a working group of international experts in macular degeneration outcomes registry development and patient advocates, facilitated by the International Consortium for Health Outcomes Measurement (ICHOM). Modified Delphi technique, supported by structured teleconferences, followed by online surveys to drive consensus decisions. Potential outcomes were identified through literature review of outcomes collected in existing registries and reported in major clinical trials. Outcomes were refined by the working group and selected based on impact on patients, relationship to good clinical care, and feasibility of measurement in routine clinical practice. Standardized measurement of the following outcomes is recommended: visual functioning and quality of life (distance visual acuity, mobility and independence, emotional well-being, reading and accessing information); number of treatments; complications of treatment; and disease control. Proposed data collection sources include administrative data, clinical data during routine clinical visits, and patient-reported sources annually. Recording the following clinical characteristics is recommended to enable risk adjustment: age; sex; ethnicity; smoking status; baseline visual acuity in both eyes; type of macular degeneration; presence of geographic atrophy, subretinal fibrosis, or pigment epithelial detachment; previous macular degeneration treatment; ocular comorbidities. The recommended minimum outcomes and pragmatic reporting standards should enable standardized, meaningful assessments and comparisons of macular degeneration treatment outcomes. Adoption could accelerate global improvements in standardized data gathering and reporting of patient-centered outcomes. This can facilitate informed decisions by patients and health care providers, plus allow long-term monitoring of aggregate data

  1. Updated standards and processes for accreditation of echocardiographic laboratories from The European Association of Cardiovascular Imaging: an executive summary.

    PubMed

    Popescu, Bogdan A; Stefanidis, Alexandros; Nihoyannopoulos, Petros; Fox, Kevin F; Ray, Simon; Cardim, Nuno; Rigo, Fausto; Badano, Luigi P; Fraser, Alan G; Pinto, Fausto; Zamorano, Jose Luis; Habib, Gilbert; Maurer, Gerald; Lancellotti, Patrizio

    2014-11-01

    Standards for echocardiographic laboratories were proposed by the European Association of Echocardiography (now the European Association of Cardiovascular Imaging) 7 years ago, to raise standards of practice and improve the quality of care. Criteria and requirements were published at that time for transthoracic, transoesophageal, and stress echocardiography. This paper reassesses and updates the quality standards to take account of experience and the technical developments of modern echocardiographic practice. It also discusses quality control, the incentives for laboratories to apply for accreditation, the re-accreditation criteria, and the current status and future prospects of the laboratory accreditation process. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com.

  2. Development and status of data quality assurance program at NASA Langley research center: Toward national standards

    NASA Technical Reports Server (NTRS)

    Hemsch, Michael J.

    1996-01-01

    As part of a continuing effort to re-engineer the wind tunnel testing process, a comprehensive data quality assurance program is being established at NASA Langley Research Center (LaRC). The ultimate goal of the program is routing provision of tunnel-to-tunnel reproducibility with total uncertainty levels acceptable for test and evaluation of civilian transports. The operational elements for reaching such levels of reproducibility are: (1) statistical control, which provides long term measurement uncertainty predictability and a base for continuous improvement, (2) measurement uncertainty prediction, which provides test designs that can meet data quality expectations with the system's predictable variation, and (3) national standards, which provide a means for resolving tunnel-to-tunnel differences. The paper presents the LaRC design for the program and discusses the process of implementation.

  3. Quality assurance of CFU-GM assays: inter-laboratory variation despite standard reagents.

    PubMed

    Lumley, M A; Burton, A; Billingham, L J; McDonald, D F; Czarnecka, H M; Milligan, D W

    1999-01-01

    To investigate the hypothesis that commercial kits for CFU-GM (colony forming unit granulocyte-macrophage) assay will reduce the interlaboratory variation noted by many workers, we carried out a quality assurance exercise in 2 parts. There were 8 participants in the first study and each performed CFU-GM assays using their in-house method and a commercial kit (Stem Cell CFU Kit, Gibco) in parallel. In the second exercise there were 10 participants and each performed CFU-GM with in-house methods and with a different commercial medium (Methocult GF H4534, Stem Cell Technologies). Twelve samples of cryopreserved peripheral blood progenitor cells (PBPC) were analysed by each participant in each part of the study. A very wide range of results was found for the different in-house methods, but standardizing the clonogenic assay with the commercial kits did not reduce the variation seen. To improve the reproducibility of CFU-GM assays between laboratories, scrupulous attention should be paid to all the steps involved in the assays, as little progress will be made by using commercial medium in isolation from efforts to reduce other sources of variation.

  4. Resin-based composite light-cured properties assessed by laboratory standards and simulated clinical conditions.

    PubMed

    Ilie, N; Bauer, H; Draenert, M; Hickel, R

    2013-01-01

    SUMMARY The following parameters were varied: 1) irradiation technique: top and bottom polymerization according to the ISO standard, and polymerization from only the top, simulating clinical situations; 2) polymerization time: 5, 10, 20, and 40 seconds; 3) storage conditions: 24 hours in distilled water, thermocycling followed by storage for four weeks in artificial saliva or alcohol. Flexural strength (FS), flexural modulus (Eflexural), indentation modulus (E), Vickers hardness (HV), and degree of conversion (DC) were measured. The laboratory results were similar to those measured by mimicking clinical conditions only at high polymerization times and mild storage conditions (20 seconds and 40 seconds and storage for 24 hours in water, and 40 seconds with aging and storing in saliva). Significantly higher DC values were measured on the top than on the bottom of a 2-mm layer for all polymerization times. Overall, 5-second and 10-second irradiation times induced significantly lower DC values compared to the currently recommended polymerization times of 20 and 40 seconds at both the top and bottom of the samples. The initial DC differences as a function of irradiation time are leveled at 24 hours of storage but seem to do well in predicting long-term material behavior. A minimum irradiation time of 20 seconds is necessary clinically to achieve the best mechanical properties with modern high-intensity light emitting diode (LED) units.

  5. A Comprehensive Subcellular Proteomic Survey of Salmonella Grown under Phagosome-Mimicking versus Standard Laboratory Conditions

    SciTech Connect

    Brown, Roslyn N.; Sanford, James A.; Park, Jea H.; Deatherage, Brooke L.; Champion, Boyd L.; Smith, Richard D.; Heffron, Fred; Adkins, Joshua N.

    2012-06-01

    Towards developing a systems-level pathobiological understanding of Salmonella enterica, we performed a subcellular proteomic analysis of this pathogen grown under standard laboratory and infection-mimicking conditions in vitro. Analysis of proteins from cytoplasmic, inner membrane, periplasmic, and outer membrane fractions yielded coverage of over 30% of the theoretical proteome. Confident subcellular location could be assigned to over 1000 proteins, with good agreement between experimentally observed location and predicted/known protein properties. Comparison of protein location under the different environmental conditions provided insight into dynamic protein localization and possible moonlighting (multiple function) activities. Notable examples of dynamic localization were the response regulators of two-component regulatory systems (e.g., ArcB, PhoQ). The DNA-binding protein Dps that is generally regarded as cytoplasmic was significantly enriched in the outer membrane for all growth conditions examined, suggestive of moonlighting activities. These observations imply the existence of unknown transport mechanisms and novel functions for a subset of Salmonella proteins. Overall, this work provides a catalog of experimentally verified subcellular protein location for Salmonella and a framework for further investigations using computational modeling.

  6. Department of Energy’s ARM Climate Research Facility External Data Center Operations Plan Located At Brookhaven National Laboratory

    SciTech Connect

    Cialella, A.; Gregory, L.; Lazar, K.; Liang, M.; Ma, L.; Tilp, A.; Wagener, R.

    2015-05-01

    The External Data Center (XDC) Operations Plan describes the activities performed to manage the XDC, located at Brookhaven National Laboratory (BNL), for the Department of Energy’s Atmospheric Radiation Measurement (ARM) Climate Research Facility. It includes all ARM infrastructure activities performed by the Data Management and Software Engineering Group (DMSE) at BNL. This plan establishes a baseline of expectation within the ARM Operations Management for the group managing the XDC.

  7. Ice Crystal Icing Engine Testing in the NASA Glenn Research Center's Propulsion Systems Laboratory (PSL): Altitude Investigation

    NASA Technical Reports Server (NTRS)

    Oliver, Michael J.

    2015-01-01

    The National Aeronautics and Space Administration conducted a full scale ice crystal icing turbofan engine test in the NASA Glenn Research Centers Propulsion Systems Laboratory (PSL) Facility in February 2013. Honeywell Engines supplied the test article, an obsolete, unmodified Lycoming ALF502-R5 turbofan engine serial number LF01 that experienced an un-commanded loss of thrust event while operating at certain high altitude ice crystal icing conditions. These known conditions were duplicated in the PSL for this testing.

  8. Differences in Anticipatory Behaviour between Rats (Rattus norvegicus) Housed in Standard versus Semi-Naturalistic Laboratory Environments

    PubMed Central

    Makowska, I. Joanna; Weary, Daniel M.

    2016-01-01

    Laboratory rats are usually kept in relatively small cages, but research has shown that they prefer larger and more complex environments. The physiological, neurological and health effects of standard laboratory housing are well established, but fewer studies have addressed the sustained emotional impact of a standard cage environment. One method of assessing affective states in animals is to look at the animals’ anticipatory behaviour between the presentation of a cue signalling the arrival of a reward and the arrival of that reward. The primary aim of this study was to use anticipatory behaviour to assess the affective state experienced by female rats a) reared and housed long-term in a standard laboratory cage versus a semi-naturalistic environment, and b) before and after treatment with an antidepressant or an anxiolytic. A secondary aim was to add to the literature on anticipatory behaviour by describing and comparing the frequency and duration of individual elements of anticipatory behaviour displayed by rats reared in these two systems. In all experiments, total behavioural frequency was higher in standard-housed rats compared to rats from the semi-naturalistic condition, suggesting that standard-housed rats were more sensitive to rewards and experiencing poorer welfare than rats reared in the semi-naturalistic environment. What rats did in anticipation of the reward also differed between housing treatments, with standard-housed rats mostly rearing and rats from the semi-naturalistic condition mostly sitting facing the direction of the upcoming treat. Drug interventions had no effect on the quantity or form of anticipatory behaviour, suggesting that the poorer welfare experienced by standard-housed rats was not analogous to depression or anxiety, or alternatively that the drug interventions were ineffective. This study adds to mounting evidence that standard laboratory housing for rats compromises rat welfare, and provides further scientific support for

  9. 42 CFR 493.1239 - Standard: General laboratory systems quality assessment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... quality assessment. (a) The laboratory must establish and follow written policies and procedures for an... quality assessment must include a review of the effectiveness of corrective actions taken to resolve... of general laboratory systems quality assessment reviews with appropriate staff. (c) The laboratory...

  10. A New Approach for Laboratory Exercise of Pathophysiology in China Based on Student-Centered Learning

    ERIC Educational Resources Information Center

    Chen, Jian; Zhou, Junhai; Sun, Li; Wu, Qiuhui; Lu, Huiling; Tian, Jing

    2015-01-01

    Student-centered learning is generally defined as any instructional method that purportedly engages students in active learning and critical thinking. The student-centered method of teaching moves the focus from teaching to learning, from the teachers' conveying course concepts via lecture to the understanding of concepts by students. The…

  11. The gallium melting-point standard: its role in manufacture and quality control of electronic thermometers for the clinical laboratory.

    PubMed

    Sostman, H E

    1977-01-01

    I discuss the traceability of calibration of electronic thermometers to thermometric constants of nature or to the National Bureau of Standards, form a manufacturer's basic standards through the manufacturing process to the user's laboratory. Useful electrical temperature sensors, their advantages, and means for resolving their disadvantages are described. I summarize our development of a cell for realizing the melting phase equilibrium of pure gallium (at 29.770 degrees C) as a thermometer calibration fixed point, and enumerate its advantages in the routine calibration verification of electrical thermometers in the clinical chemistry laboratory.

  12. Changes across Three Editions of "The Suicidal Patient: Clinical and Legal Standards of Care": Relevance to Counseling Centers

    ERIC Educational Resources Information Center

    Polychronis, Paul D.

    2017-01-01

    Treating suicidality is one of the most challenging situations managed by college and university counseling centers. The first edition of Bongar's (1991) "The Suicidal Patient: Clinical and Legal Standards of Care," a compendium of empirical knowledge and clinical research regarding standard of care in the treatment of suicidality, was…

  13. Changes across Three Editions of "The Suicidal Patient: Clinical and Legal Standards of Care": Relevance to Counseling Centers

    ERIC Educational Resources Information Center

    Polychronis, Paul D.

    2017-01-01

    Treating suicidality is one of the most challenging situations managed by college and university counseling centers. The first edition of Bongar's (1991) "The Suicidal Patient: Clinical and Legal Standards of Care," a compendium of empirical knowledge and clinical research regarding standard of care in the treatment of suicidality, was…

  14. [Audit of clinical trials in Argentina. Assessment of standardized operational procedures in 12 centers].

    PubMed

    Forti, I N; Barousse, A P; Bernabó, J G

    1991-01-01

    The purpose of these audits was to ensure the quality, integrity and validity of investigational data. Audits were performed by control of compliance to standard operational procedures (SOPs) for Good Clinical Practice (GCP). Guidelines were proposed and established by the Food and Drug Administration (FDA) in 1977-1979 and adopted by several countries of the European Community in 1987-1989 and 1990. In Argentina, 12 on site audits of clinical trials performed between 1987 and 1990, were carried out. Basic data of GCP, audited in 58 out of 153 patients included in 12 different centers, were: protection of individual rights, compliance to standard operational procedures, adverse event reports, access to original investigational data and source document archives. The analysis of all audited data showed that patient case reports form recorded findings are credible and reliable and that researchers and monitors had conducted the study with an acceptable level in accordance to SOPs of good clinical practice. Otherwise, several in need of change to obtain better clinical data were identified: ethical committees, written informed consent, protocol adherence, data record, drug accountability, document source archives and the necessity of a thorough theorical and practical training on SOPs for GCP for researchers and monitors of clinical trials.

  15. Laboratory test utilization program: structure and impact in a large academic medical center.

    PubMed

    Warren, Jeffrey S

    2013-03-01

    In 2008, the University of Michigan Health System (UMHS) created a Laboratory Test Utilization Program that included the establishment of a Laboratory Formulary Committee under the imprimatur of the Faculty Group Practice, the Office of Clinical Affairs, the Department of Pathology, and UMHS hospital administration. A critical component of the program is UM-CareLink, an order entry system for inpatients and inpatient-like venues. UM-CareLink allows very basic decision support comment prompts. Through the application of peer-reviewed medical evidence, input by medical content experts, excellent cooperation by medical staff, and close oversight by Pathology of the Sendout Laboratory, this program has led to a robust process of test utilization oversight, excellent communication with clinical services, and significant UMHS activity-adjusted reductions in laboratory expense.

  16. [Harmonization procedures directed toward clinical trials in laboratory medicine at the National Cancer Center Hospital].

    PubMed

    Ozeki, Mitsuru; Shioya, Kana; Furuta, Koh

    2009-09-01

    Recent advances in pharmacology and molecular sciences made it possible to develop drugs for patients with various maladies. Frustration has existed concerning the delayed provision of these drugs for routine practices in the clinical field. To correct this problem, the importance of clinical trials is increasing. Although there exists a strong demand for participation of clinical laboratories in clinical trials, an awkward attitude in clinical laboratories frustrates those performing clinical trials. We are attempting to correct this problem by introducing our experience with harmonization procedures directed toward clinical trials in laboratory medicine in general. First we described the current status of clinical trials in our hospital. Then we will show personnel in need for clinical trials. Finally we describe in detail our clinical trial procedures. We focus particularly on three aspects of participation in clinical trials: pre-analytical, analytical, and post analytical. Additionally we describe the problems and perspectives in clinical trials by giving special reference to the clinical laboratories in general through discussion with various personnel and specialists. Our goal in the field of laboratory medicine is to benefit patients through the establishment of a harmony between clinical trials and clinical laboratories.

  17. EBMT transplant centers with FACT-JACIE accreditation have significantly better compliance with related donor care standards

    PubMed Central

    Anthias, Chloe; O'Donnell, Paul V; Kiefer, Deidre M; Yared, Jean; Norkin, Maxim; Anderlini, Paolo; Savani, Bipin N; Diaz, Miguel A; Bitan, Menachem; Halter, Joerg P; Logan, Brent R; Switzer, Galen E; Pulsipher, Michael A; Confer, Dennis L; Shaw, Bronwen E

    2016-01-01

    Previous studies have identified healthcare practices that may place undue pressure on related donors (RDs) of hematopoietic cell products, and an increase in serious adverse events associated with morbidities in this population. As a result, specific requirements to safeguard RD health have been introduced to FACT-JACIE Standards, but the impact of accreditation on RD care has not previously been evaluated. A survey of transplant program directors of EBMT member centers was conducted by the Donor Health and Safety Working Committee of the Center for International Blood and Marrow Transplant Research (CIBMTR) to test the hypothesis that RD care in FACT-JACIE accredited centers is more closely aligned with international consensus donor care recommendations than RD care delivered in centers without accreditation. Responses were received from 39% of 304 centers. Our results show that practice in accredited centers was much closer to recommended standards as compared to non-accredited centers. Specifically, a higher percentage of accredited centers use eligibility criteria to assess RDs (93% versus 78%; P=0.02) and a lower percentage have a single physician simultaneously responsible for a RD and their recipient (14% versus 35%; P=0.008). In contrast, where regulatory standards do not exist, both accredited and non-accredited centers fell short of accepted best practice. These results raise concerns that despite improvements in care, current practice can place undue pressure on donors, and may increase the risk of donation-associated adverse events. We recommend measures to address these issues through enhancement of regulatory standards as well as national initiatives to standardize RD care. PMID:26597079

  18. Validation Ice Crystal Icing Engine Test in the Propulsion Systems Laboratory at NASA Glenn Research Center

    NASA Technical Reports Server (NTRS)

    Oliver, Michael J.

    2014-01-01

    The Propulsion Systems Laboratory (PSL) is an existing altitude simulation jet engine test facility located at NASA Glenn Research Center in Clevleand, OH. It was modified in 2012 with the integration of an ice crystal cloud generation system. This paper documents the inaugural ice crystal cloud test in PSLthe first ever full scale, high altitude ice crystal cloud turbofan engine test to be conducted in a ground based facility. The test article was a Lycoming ALF502-R5 high bypass turbofan engine, serial number LF01. The objectives of the test were to validate the PSL ice crystal cloud calibration and engine testing methodologies by demonstrating the capability to calibrate and duplicate known flight test events that occurred on the same LF01 engine and to generate engine data to support fundamental and computational research to investigate and better understand the physics of ice crystal icing in a turbofan engine environment while duplicating known revenue service events and conducting test points while varying facility and engine parameters. During PSL calibration testing it was discovered than heated probes installed through tunnel sidewalls experienced ice buildup aft of their location due to ice crystals impinging upon them, melting and running back. Filtered city water was used in the cloud generation nozzle system to provide ice crystal nucleation sites. This resulted in mineralization forming on flow path hardware that led to a chronic degradation of performance during the month long test. Lacking internal flow path cameras, the response of thermocouples along the flow path was interpreted as ice building up. Using this interpretation, a strong correlation between total water content (TWC) and a weaker correlation between median volumetric diameter (MVD) of the ice crystal cloud and the rate of ice buildup along the instrumented flow path was identified. For this test article the engine anti-ice system was required to be turned on before ice crystal icing

  19. Validation Ice Crystal Icing Engine Test in the Propulsion Systems Laboratory at NASA Glenn Research Center

    NASA Technical Reports Server (NTRS)

    Oliver, Michael J.

    2014-01-01

    The Propulsion Systems Laboratory (PSL) is an existing altitude simulation jet engine test facility located at NASA Glenn Research Center in Cleveland, OH. It was modified in 2012 with the integration of an ice crystal cloud generation system. This paper documents the inaugural ice crystal cloud test in PSL--the first ever full scale, high altitude ice crystal cloud turbofan engine test to be conducted in a ground based facility. The test article was a Lycoming ALF502-R5 high bypass turbofan engine, serial number LF01. The objectives of the test were to validate the PSL ice crystal cloud calibration and engine testing methodologies by demonstrating the capability to calibrate and duplicate known flight test events that occurred on the same LF01 engine and to generate engine data to support fundamental and computational research to investigate and better understand the physics of ice crystal icing in a turbofan engine environment while duplicating known revenue service events and conducting test points while varying facility and engine parameters. During PSL calibration testing it was discovered than heated probes installed through tunnel sidewalls experienced ice buildup aft of their location due to ice crystals impinging upon them, melting and running back. Filtered city water was used in the cloud generation nozzle system to provide ice crystal nucleation sites. This resulted in mineralization forming on flow path hardware that led to a chronic degradation of performance during the month long test. Lacking internal flow path cameras, the response of thermocouples along the flow path was interpreted as ice building up. Using this interpretation, a strong correlation between total water content (TWC) and a weaker correlation between median volumetric diameter (MVD) of the ice crystal cloud and the rate of ice buildup along the instrumented flow path was identified. For this test article the engine anti-ice system was required to be turned on before ice crystal

  20. Procedures of Exercise Physiology Laboratories

    NASA Technical Reports Server (NTRS)

    Bishop, Phillip A.; Fortney, Suzanne; Greenisen, Michael; Siconolfi, Steven F.; Bamman, Marcas M.; Moore, Alan D., Jr.; Squires, William

    1998-01-01

    This manual describes the laboratory methods used to collect flight crew physiological performance data at the Johnson Space Center. The Exercise Countermeasures Project Laboratory is a standard physiology laboratory; only the application to the study of human physiological adaptations to spaceflight is unique. In the absence of any other recently published laboratory manual, this manual should be a useful document staffs and students of other laboratories.

  1. Annual report procurement and logistics management center Sandia National Laboratories fiscal year 2002.

    SciTech Connect

    Palmer, David L.

    2003-05-01

    This report summarizes the purchasing and transportation activities of the Procurement and Logistics Management Center for Fiscal Year 2002. Activities for both the New Mexico and California locations are included.

  2. National Fuel Cell Technology Evaluation Center (NFCTEC); (NREL) National Renewable Energy Laboratory

    SciTech Connect

    Kurtz, Jennifer; Sprik, Sam

    2014-03-11

    This presentation gives an overview of the National Fuel Cell Technology Evaluation Center (NFCTEC), describes how NFCTEC benefits the hydrogen and fuel cell community, and introduces a new fuel cell cost/price aggregation project.

  3. Development of a Fan-Filter Unit Test Standard, LaboratoryValidations, and its Applications across Industries

    SciTech Connect

    Xu, Tengfang

    2006-10-20

    Lawrence Berkeley National Laboratory (LBNL) is now finalizing the Phase 2 Research and Demonstration Project on characterizing 2-foot x 4-foot (61-cm x 122-cm) fan-filter units in the market using the first-ever standard laboratory test method developed at LBNL.[1][2][3] Fan-filter units deliver re-circulated air and provide particle filtration control for clean environments. Much of the energy in cleanrooms (and minienvironments) is consumed by 2-foot x 4-foot (61-cm x 122-cm) or 4-foot x 4-foot (122-cm x 122-cm) fan-filter units that are typically located in the ceiling (25-100% coverage) of cleanroom controlled environments. Thanks to funding support by the California Energy Commission's Industrial Program of the Public Interest Energy Research (PIER) Program, and significant participation from manufacturers and users of fan-filter units from around the world, LBNL has developed and performed a series of standard laboratory tests and reporting on a variety of 2-foot x 4-foot (61-cm x 122-cm) fan-filter units (FFUs). Standard laboratory testing reports have been completed and reported back to anonymous individual participants in this project. To date, such reports on standard testing of FFU performance have provided rigorous and useful data for suppliers and end users to better understand, and more importantly, to quantitatively characterize performance of FFU products under a variety of operating conditions.[1] In the course of the project, the standard laboratory method previously developed at LBNL has been under continuous evaluation and update.[2][3] Based upon the updated standard, it becomes feasible for users and suppliers to characterize and evaluate energy performance of FFUs in a consistent way.

  4. Evaluation of a Consensus-Based Criterion Standard Definition of Trauma Center Need for Use in Field Triage Research.

    PubMed

    Willenbring, Brian D; Lerner, E Brooke; Brasel, Karen; Cushman, Jeremy T; Guse, Clare E; Shah, Manish N; Swor, Robert

    2016-01-01

    Research on field triage of injured patients is limited by the lack of a widely used criterion standard for defining trauma center need. Injury Severity Score (ISS) >15 has been a commonly used outcome measure in research for determining trauma center need that has never been validated. A multidisciplinary team recently published a consensus-based criterion standard definition of trauma center need, but this measure has not yet been validated. The objective was to determine if the consensus-based criterion standard can be obtained by medical record review and compare patients identified as needing a trauma center by the consensus-based criterion standard vs. ISS >15. A subanalysis of data collected during a 2-year prospective cohort study of 4,528 adult trauma patients transported by EMS to a single trauma center was conducted. These data included ICD-9-CM codes, treatment times, and other patient care data. Presence of the consensus-based criterion standard was determined for each patient. ISS was calculated based on ICD-9-CM codes assigned for billing. The consensus-based criterion standard could be applied to 4,471 (98.7%) cases. ISS could be determined for 4,506 (99.5%) cases. Based on an ISS >15, 8.9% of cases were identified as needing a trauma center. Of those, only 48.2% met the consensus-based criterion standard. Almost all patients that did not meet the consensus-based criterion standard, but had an ISS >15 were diagnosed with chest (rib fractures (100/205 cases)/pneumothorax (57/205 cases), closed head (without surgical intervention 88/205 cases), vertebral (without spinal cord injury 45/205 cases), and/or extremity injuries (39/205 cases). There were 4,053 cases with an ISS <15. 5.0% of those with an ISS <15 met the consensus-based criterion standard with the majority requiring surgery (139/203 cases) or a blood transfusion (60/203 cases). The kappa coefficient of agreement for ISS and the consensus-based criterion standard was 0.43. We determined that

  5. Principles of analytic validation of immunohistochemical assays: Guideline from the College of American Pathologists Pathology and Laboratory Quality Center.

    PubMed

    Fitzgibbons, Patrick L; Bradley, Linda A; Fatheree, Lisa A; Alsabeh, Randa; Fulton, Regan S; Goldsmith, Jeffrey D; Haas, Thomas S; Karabakhtsian, Rouzan G; Loykasek, Patti A; Marolt, Monna J; Shen, Steven S; Smith, Anthony T; Swanson, Paul E

    2014-11-01

    Laboratories must validate all assays before they can be used to test patient specimens, but currently there are no evidence-based guidelines regarding validation of immunohistochemical assays. To develop recommendations for initial analytic validation and revalidation of immunohistochemical assays. The College of American Pathologists Pathology and Laboratory Quality Center convened a panel of pathologists and histotechnologists with expertise in immunohistochemistry to develop validation recommendations. A systematic evidence review was conducted to address key questions. Electronic searches identified 1463 publications, of which 126 met inclusion criteria and were extracted. Individual publications were graded for quality, and the key question findings for strength of evidence. Recommendations were derived from strength of evidence, open comment feedback, and expert panel consensus. Fourteen guideline statements were established to help pathology laboratories comply with validation and revalidation requirements for immunohistochemical assays. Laboratories must document successful analytic validation of all immunohistochemical tests before applying to patient specimens. The parameters for cases included in validation sets, including number, expression levels, fixative and processing methods, should take into account intended use and should be sufficient to ensure that the test accurately measures the analyte of interest in specimens tested in that laboratory. Recommendations are also provided for confirming assay performance when there are changes in test methods, reagents, or equipment.

  6. [The quality management in clinical diagnostic laboratory in conditions of the Federal Center of traumatology, orthopedics and endoprosthesis replacement of Minzdrav of Russia (Cheboksary)].

    PubMed

    Nikolaev, N S; Nazarova, V V; Dobrovol'skaia, N Iu; Orlova, A V; Pchelova, N N

    2014-10-01

    The article presents experience of clinical diagnostic laboratory of the Federal Center of traumatology, orthopedics and endoprosthesis replacement of Minzdrav of Russia (Cheboksary) in the area of quality management of medical laboratory services on the basis of evaluation of efficacy and effectiveness of processes. The factors effecting quality of functioning of clinical diagnostic laboratory are indicated. The criteria and indicators of efficacy of work of employees of clinical diagnostic laboratory are presented.

  7. Using a medical simulation center as an electronic health record usability laboratory

    PubMed Central

    Landman, Adam B; Redden, Lisa; Neri, Pamela; Poole, Stephen; Horsky, Jan; Raja, Ali S; Pozner, Charles N; Schiff, Gordon; Poon, Eric G

    2014-01-01

    Usability testing is increasingly being recognized as a way to increase the usability and safety of health information technology (HIT). Medical simulation centers can serve as testing environments for HIT usability studies. We integrated the quality assurance version of our emergency department (ED) electronic health record (EHR) into our medical simulation center and piloted a clinical care scenario in which emergency medicine resident physicians evaluated a simulated ED patient and documented electronically using the ED EHR. Meticulous planning and close collaboration with expert simulation staff was important for designing test scenarios, pilot testing, and running the sessions. Similarly, working with information systems teams was important for integration of the EHR. Electronic tools are needed to facilitate entry of fictitious clinical results while the simulation scenario is unfolding. EHRs can be successfully integrated into existing simulation centers, which may provide realistic environments for usability testing, training, and evaluation of human–computer interactions. PMID:24249778

  8. A knowledge continuity management program for the energy, infrastructure and knowledge systems center, Sandia National Laboratories.

    SciTech Connect

    Menicucci, David F.

    2006-07-01

    A growing recognition exists in companies worldwide that, when employees leave, they take with them valuable knowledge that is difficult and expensive to recreate. The concern is now particularly acute as the large ''baby boomer'' generation is reaching retirement age. A new field of science, Knowledge Continuity Management (KCM), is designed to capture and catalog the acquired knowledge and wisdom from experience of these employees before they leave. The KCM concept is in the final stages of being adopted by the Energy, Infrastructure, and Knowledge Systems Center and a program is being applied that should produce significant annual cost savings. This report discusses how the Center can use KCM to mitigate knowledge loss from employee departures, including a concise description of a proposed plan tailored to the Center's specific needs and resources.

  9. Protocol standards and implementation within the digital engineering laboratory computer network (DELNET) using the universal network interface device (UNID). Part 2

    NASA Astrophysics Data System (ADS)

    Phister, P. W., Jr.

    1983-12-01

    Development of the Air Force Institute of Technology's Digital Engineering Laboratory Network (DELNET) was continued with the development of an initial draft of a protocol standard for all seven layers as specified by the International Standards Organization's (ISO) Reference Model for Open Systems Interconnections. This effort centered on the restructuring of the Network Layer to perform Datagram routing and to conform to the developed protocol standards and actual software module development of the upper four protocol layers residing within the DELNET Monitor (Zilog MCZ 1/25 Computer System). Within the guidelines of the ISO Reference Model the Transport Layer was developed utilizing the Internet Header Format (IHF) combined with the Transport Control Protocol (TCP) to create a 128-byte Datagram. Also a limited Application Layer was created to pass the Gettysburg Address through the DELNET. This study formulated a first draft for the DELNET Protocol Standard and designed, implemented, and tested the Network, Transport, and Application Layers to conform to these protocol standards.

  10. Laboratory of Viral Diseases Guest Researcher Seminar Series | Center for Cancer Research

    Cancer.gov

    Laboratory of Viral Diseases Guest Researcher Seminar Series New Epigenetic Regulators of HIV Latency Speaker: Melanie Ott, M.D., Ph.D, Senior Investigator & Professor of Medicine Gladstone Institutes & University of California Building 33, Main Conference Room 1N09 Main NIH CAMPUS *BLDG 33 is a secure facility, please allow time to pass through security.

  11. Using a Thematic Laboratory-Centered Curriculum to Teach General Chemistry

    ERIC Educational Resources Information Center

    Hopkins, Todd A.; Samide, Michael

    2013-01-01

    This article describes an approach to general chemistry that involves teaching chemical concepts in the context of two thematic laboratory modules: environmental remediation and the fate of pharmaceuticals in the environment. These modules were designed based on active-learning pedagogies and involve multiple-week projects that dictate what…

  12. The Analysis of Seawater: A Laboratory-Centered Learning Project in General Chemistry.

    ERIC Educational Resources Information Center

    Selco, Jodye I.; Roberts, Julian L., Jr.; Wacks, Daniel B.

    2003-01-01

    Describes a sea-water analysis project that introduces qualitative and quantitative analysis methods and laboratory methods such as gravimetric analysis, potentiometric titration, ion-selective electrodes, and the use of calibration curves. Uses a problem-based cooperative teaching approach. (Contains 24 references.) (YDS)

  13. The Analysis of Seawater: A Laboratory-Centered Learning Project in General Chemistry.

    ERIC Educational Resources Information Center

    Selco, Jodye I.; Roberts, Julian L., Jr.; Wacks, Daniel B.

    2003-01-01

    Describes a sea-water analysis project that introduces qualitative and quantitative analysis methods and laboratory methods such as gravimetric analysis, potentiometric titration, ion-selective electrodes, and the use of calibration curves. Uses a problem-based cooperative teaching approach. (Contains 24 references.) (YDS)

  14. Using a Thematic Laboratory-Centered Curriculum to Teach General Chemistry

    ERIC Educational Resources Information Center

    Hopkins, Todd A.; Samide, Michael

    2013-01-01

    This article describes an approach to general chemistry that involves teaching chemical concepts in the context of two thematic laboratory modules: environmental remediation and the fate of pharmaceuticals in the environment. These modules were designed based on active-learning pedagogies and involve multiple-week projects that dictate what…

  15. An Alternative Approach for Preparing and Standardizing Some Common Aqueous Reagents Used in an Undergraduate Laboratory

    ERIC Educational Resources Information Center

    Melaku, Samuel; Dabke, Rajeev B.

    2014-01-01

    A guide for instructors and laboratory assistants to prepare some common aqueous reagents used in an undergraduate laboratory is presented. Dilute reagents consisting of H[superscript +](aq), I[subscript 3][superscript-](aq), Ce[superscript 4+](aq), and Ag[superscript+](aq) were prepared by electrolytic oxidation of respective precursors.…

  16. An Alternative Approach for Preparing and Standardizing Some Common Aqueous Reagents Used in an Undergraduate Laboratory

    ERIC Educational Resources Information Center

    Melaku, Samuel; Dabke, Rajeev B.

    2014-01-01

    A guide for instructors and laboratory assistants to prepare some common aqueous reagents used in an undergraduate laboratory is presented. Dilute reagents consisting of H[superscript +](aq), I[subscript 3][superscript-](aq), Ce[superscript 4+](aq), and Ag[superscript+](aq) were prepared by electrolytic oxidation of respective precursors.…

  17. Construction of the Savannah River Ecology Laboratory Conference Center. Environmental Assessment

    SciTech Connect

    Not Available

    1993-07-01

    This Environmental Assessment (EA) reviews the environmental consequences associated with the proposed action of granting a site use permit to construct and operate a conference center on an approximately 70-acre tract of land on the Savannah River Site (SRS). While the proposed action requires an administrative decision by DOE, this EA reviews the linked action of physically constructing and operating a conference center. The SRS is a DOE-owned nuclear production facility encompassing approximately 200,000 acres in southwestern South Carolina. The proposed conference center would have an area of approximately 4,000 square feet, and would infrequently accommodate as many as 150 people, with the average being about 20 people per day. In addition to the No-Action alternative, under which the Research Foundation would not require the 70-acre tract of SRS land for a conference center, this EA considers site preservation. Under Site Preservation only minimal activities necessary to the SRS mission would occur, thereby establishing the lower limits of environmental consequences. A review conducted under the SRS permitting process identified no other forms of possible site development. Similarly, SRS areas identified in the Nuclear Complex Reconfiguration Site Proposal (DOE, 199la) do not include the conference center site area in proposed weapons complex reconfiguration activities. As a consequence, this EA does not consider other forms of possible site development as alternatives. The potential environmental consequences associated with the action of constructing and operating a conference center include impacts to cultural resources and impacts from construction activities, primarily related to land clearing (5 to 10 acres) and providing access to the site.

  18. Clinical and clinical laboratory correlates in sea otters dying unexpectedly in rehabilitation centers following the Exxon Valdez oil spill.

    PubMed

    Rebar, A H; Lipscomb, T P; Harris, R K; Ballachey, B E

    1995-07-01

    Following the Exxon Valdez oil spill, 347 oiled sea otters (Enhydra lutris) were treated in rehabilitation centers. Of these, 116 died, 94 within 10 days of presentation. Clinical records of 21 otters dying during the first 10 days of rehabilitation were reviewed to define the laboratory abnormalities and clinical syndromes associated with these unexpected deaths. The most common terminal syndrome was shock characterized by hypothermia, lethargy, and often hemorrhagic diarrhea. In heavily and moderately oiled otters, shock developed within 48 hours of initial presentation, whereas in lightly oiled otters shock generally occurred during the second week of captivity. Accompanying laboratory abnormalities included leukopenia with increased numbers of immature neutrophils (degenerative left shift), lymphopenia, anemia, azotemia (primarily prerenal), hyperkalemia, hypoproteinemia/hypoalbuminemia, elevations of serum transaminases, and hypoglycemia. Shock associated with hemorrhagic diarrhea probably occurred either as a direct primary effect of oiling or as an indirect effect secondary to confinement and handling in the rehabilitation centers. Lightly oiled otters were less likely to die from shock than were heavily oiled otters (22% vs. 72%, respectively). Heavily oiled otters developed shock more rapidly and had greater numbers of laboratory abnormalities, suggesting that exposure to oil was an important contributing factor.

  19. Clinical and clinical laboratory correlates in sea otters dying unexpectedly in rehabilitation centers following the Exxon Valdez oil spill

    USGS Publications Warehouse

    Rebar, A.H.; Lipscomb, T.P.; Harris, R.K.; Ballachey, B.E.

    1995-01-01

    Following the Exxon Valdez oil spill, 347 oiled sea otters (Enhydra lutris) were treated in rehabilitation centers. Of these, 116 died, 94 within 10 days of presentation. Clinical records of 21 otters dying during the first 10 days of rehabilitation were reviewed to define the laboratory abnormalities and clinical syndromes associated with these unexpected deaths. The most common terminal syndrome was shock characterized by hypothermia, lethargy, and often hemorrhagic diarrhea. In heavily and moderately oiled otters, shock developed within 48 hours of initial presentation, whereas in lightly oiled otters shock generally occurred during the second week of captivity. Accompanying laboratory abnormalities included leukopenia with increased numbers of immature neutrophils (degenerative left shift), lymphopenia, anemia, azotemia (primarily prerenal), hyperkalemia, hypoproteinemia/hypoalbuminemia, elevations of serum transaminases, and hypoglycemia. Shock associated with hemorrhagic diarrhea probably occurred either as a direct primary effect of oiling or as an indirect effect secondary to confinement and handling in the rehabilitation centers. Lightly oiled otters were less likely to die from shock than were heavily oiled otters (22% vs. 72%, respectively). Heavily oiled otters developed shock more rapidly and had greater numbers of laboratory abnormalities, suggesting that exposure to oil was an important contributing factor.

  20. ORNL (Oak Ridge National Laboratory) Controlled Fusion Atomic Data Center: Thirty years later

    SciTech Connect

    Hunter, H.T.; Phaneuf, R.A.; Kirkpatrick, M.I.

    1990-08-01

    The ORNL Controlled Fusion Atomic Data Center (CFADC) handles requests for information and data on fusion processes, maintains a comprehensive bibliographical database, and publishes recommended atomic collision data in what have been popularly called Redbooks,'' to support the fusion community's current atomic and molecular data needs. A recent improvement in the efficiency and operation of the data center has been the addition of a customized database management system implemented on a personal computer system in 1988, and a desktop publishing station in 1989. This paper will describe the present scheme for handling numerical and bibliographic data and emphasize how they facilitate the mission of the CFADC. 1 ref.

  1. Functions and activities of the Area Committee on Microbiology of the National Committee for Clinical Laboratory Standards.

    PubMed Central

    Washington, J A

    1991-01-01

    The Area Committee on Microbiology of the National Committee for Clinical Laboratory Standards has responsibility for the development of guidelines and standards in the field of clinical microbiology. Through the consensus process, representatives from government, industry, and professional societies have developed standards on antibacterial susceptibility testing (M2, M7, and M11), antimycobacterial susceptibility testing (M24), quality assurance on commercially prepared microbiological culture media (M22), evaluation of production lots of dehydrated Mueller-Hinton agar (M6), and preparation and testing of fetal bovine serum for use as cell culture growth supplement (M25) and guidelines on bactericidal tests (M26), protection of laboratory workers from infections transmitted by blood, body fluids, and tissue (M29), blood film examination for parasites (M15), and development of in vitro susceptibility testing criteria and quality control parameters (M23). PMID:2070343

  2. A description of the Galactic Center excess in the Minimal Supersymmetric Standard Model

    SciTech Connect

    Achterberg, Abraham; Caron, Sascha; Hendriks, Luc; Amoroso, Simone; De Austri, Roberto Ruiz

    2015-08-01

    Observations with the Fermi Large Area Telescope (LAT) indicate an excess in gamma rays originating from the center of our Galaxy. A possible explanation for this excess is the annihilation of Dark Matter particles. We have investigated the annihilation of neutralinos as Dark Matter candidates within the phenomenological Minimal Supersymmetric Standard Model (pMSSM) . An iterative particle filter approach was used to search for solutions within the pMSSM . We found solutions that are consistent with astroparticle physics and collider experiments, and provide a fit to the energy spectrum of the excess. The neutralino is a Bino/Higgsino or Bino/Wino/Higgsino mixture with a mass in the range 84–92 GeV or 87–97 GeV annihilating into W bosons. A third solutions is found for a neutralino of mass 174–187 GeV annihilating into top quarks. The best solutions yield a Dark Matter relic density 0.06 < Ω h{sup 2} <0.13. These pMSSM solutions make clear forecasts for LHC, direct and indirect DM detection experiments. If the pMSSM explanation of the excess seen by Fermi-LAT is correct, a DM signal might be discovered soon.

  3. A description of the Galactic Center excess in the Minimal Supersymmetric Standard Model

    SciTech Connect

    Achterberg, Abraham; Amoroso, Simone; Caron, Sascha; Hendriks, Luc; Austri, Roberto Ruiz de

    2015-08-03

    Observations with the Fermi Large Area Telescope (LAT) indicate an excess in gamma rays originating from the center of our Galaxy. A possible explanation for this excess is the annihilation of Dark Matter particles. We have investigated the annihilation of neutralinos as Dark Matter candidates within the phenomenological Minimal Supersymmetric Standard Model (pMSSM). An iterative particle filter approach was used to search for solutions within the pMSSM. We found solutions that are consistent with astroparticle physics and collider experiments, and provide a fit to the energy spectrum of the excess. The neutralino is a Bino/Higgsino or Bino/Wino/Higgsino mixture with a mass in the range 84–92 GeV or 87–97 GeV annihilating into W bosons. A third solutions is found for a neutralino of mass 174–187 GeV annihilating into top quarks. The best solutions yield a Dark Matter relic density 0.06<Ωh{sup 2}<0.13. These pMSSM solutions make clear forecasts for LHC, direct and indirect DM detection experiments. If the pMSSM explanation of the excess seen by Fermi-LAT is correct, a DM signal might be discovered soon.

  4. WASTE MINIMIZATION OPPORTUNITY ASSESSMENT: OPTICAL FABRICATION LABORATORY - FITZSIMMONS ARMY MEDICAL CENTER

    EPA Science Inventory

    Under the Waste Reduction Evaluations at Federal Sites (WREAFS) program, RREL has taken the initiative to merge the experience and resources of the EPA with other Federal agencies. At the Fitzsimmons Army Medical Center (FAMC) in Aurora, Colorado, the Army and the EPA cooperated ...

  5. WASTE MINIMIZATION OPPORTUNITY ASSESSMENT: OPTICAL FABRICATION LABORATORY - FITZSIMMONS ARMY MEDICAL CENTER

    EPA Science Inventory

    Under the Waste Reduction Evaluations at Federal Sites (WREAFS) program, RREL has taken the initiative to merge the experience and resources of the EPA with other Federal agencies. At the Fitzsimmons Army Medical Center (FAMC) in Aurora, Colorado, the Army and the EPA cooperated ...

  6. Control Systems Security Center Comparison Study of Industrial Control System Standards against the Control Systems Protection Framework Cyber-Security Requirements

    SciTech Connect

    Robert P. Evans

    2005-09-01

    Cyber security standards, guidelines, and best practices for control systems are critical requirements that have been delineated and formally recognized by industry and government entities. Cyber security standards provide a common language within the industrial control system community, both national and international, to facilitate understanding of security awareness issues but, ultimately, they are intended to strengthen cyber security for control systems. This study and the preliminary findings outlined in this report are an initial attempt by the Control Systems Security Center (CSSC) Standard Awareness Team to better understand how existing and emerging industry standards, guidelines, and best practices address cyber security for industrial control systems. The Standard Awareness Team comprised subject matter experts in control systems and cyber security technologies and standards from several Department of Energy (DOE) National Laboratories, including Argonne National Laboratory, Idaho National Laboratory, Pacific Northwest National Laboratory, and Sandia National Laboratories. This study was conducted in two parts: a standard identification effort and a comparison analysis effort. During the standard identification effort, the Standard Awareness Team conducted a comprehensive open-source survey of existing control systems security standards, regulations, and guidelines in several of the critical infrastructure (CI) sectors, including the telecommunication, water, chemical, energy (electric power, petroleum and oil, natural gas), and transportation--rail sectors and sub-sectors. During the comparison analysis effort, the team compared the requirements contained in selected, identified, industry standards with the cyber security requirements in ''Cyber Security Protection Framework'', Version 0.9 (hereafter referred to as the ''Framework''). For each of the seven sector/sub-sectors listed above, one standard was selected from the list of standards identified

  7. Prognostic impact of standard laboratory values on outcome in patients with sudden sensorineural hearing loss

    PubMed Central

    2014-01-01

    Background Aim of the present study was to evaluate prognostic factors, in particular standard laboratory parameters, for better outcome after idiopathic sudden sensorineural hearing loss (SSNHL). Methods Using a retrospective review, 173 patients were included presenting between 2006 and 2009 with unilateral SSNHL, ≥30 dB bone conduction in three succeeding frequencies between 0.125 to 8 kHz in pure tone audiometry (PTA), and a time interval between first symptoms and diagnostics ≤ 4 weeks. Hearing gain of <10 dB versus ≥10 dB in the affected ear in 6PTA values was the primary outcome criterion. Univariate and multivariate statistical tests were used to analyze predictors for better outcome. Results The initial hearing loss was 50.6 ± 27.2 dB. The absolute hearing gain was 15.6 ± 20.1 dB. Eighty-one patients (47%) had a final hearing gain of ≥10 dB. Low-frequency hearing loss (p <0.0001); start of inpatient treatment <4 days after onset (p = 0.018); first SSNHL (versus recurrent SSNHL, p = 0.001); initial hearing loss ≥ 60 dB (p < 0.0001); an initial quick value lower than the reference values (p = 0.040); and a pretherapeutic hyperfibrinogenemia (p = 0.007) were significantly correlated to better outcome (≥10 dB absolute hearing gain). Multivariate analysis revealed that first SSNHL (p = 0.004), start of treatment <4 days after onset (p = 0.015), initial hearing loss ≥ 60 dB (p = 0.001), and hyperfibrinogenemia (p = 0.032) were independent prognostic factors for better hearing recovery. Conclusion Better hearing gain in patients with hyperfibrinogenemia might be explained by the rheological properties of the applied therapy and supports the hypothesis that SSNHL is caused in part by vascular factors. PMID:25028570

  8. Los Alamos National Laboratory new generation standard nuclear material storage container - the SAVY4000 design

    SciTech Connect

    Stone, Timothy Amos

    2010-01-01

    Incidents involving release of nuclear materials stored in containers of convenience such as food pack cans, slip lid taped cans, paint cans, etc. has resulted in defense board concerns over the lack of prescriptive performance requirements for interim storage of nuclear materials. Los Alamos National Laboratory (LANL) has shared in these incidents and in response proactively moved into developing a performance based standard involving storage of nuclear material (RD003). This RD003 requirements document has sense been updated to reflect requirements as identified with recently issued DOE M 441.1-1 'Nuclear Material Packaging Manual'. The new packaging manual was issued at the encouragement of the Defense Nuclear Facilities Safety Board with a clear directive for protecting the worker from exposure due to loss of containment of stored materials. The Manual specifies a detailed and all inclusive approach to achieve a high level of protection; from package design & performance requirements, design life determinations of limited life components, authorized contents evaluations, and surveillance/maintenance to ensure in use package integrity over time. Materials in scope involve those stored outside an approved engineered-contamination barrier that would result in a worker exposure of in excess of 5 rem Committed Effective Does Equivalent (CEDE). Key aspects of meeting the challenge as developed around the SAVY-3000 vented storage container design will be discussed. Design performance and acceptance criteria against the manual, bounding conditions as established that the user must ensure are met to authorize contents in the package (based upon the activity of heat-source plutonium (90% Pu-238) oxide, which bounds the requirements for weapons-grade plutonium oxide), interface as a safety class system within the facility under the LANL plutonium facility DSA, design life determinations for limited life components, and a sense of design specific surveillance program

  9. How to achieve ultrasound-guided femoral venous access: the new standard of care in the electrophysiology laboratory.

    PubMed

    Wiles, Benedict M; Child, Nicholas; Roberts, Paul R

    2017-06-01

    Bedside vascular ultrasound machines are increasingly available. They are used to facilitate safer vascular access across a number of different specialties. In the electrophysiology laboratory however, where patients are frequently anticoagulated and require the insertion of multiple venous sheaths, anatomical landmark techniques predominate. Despite the high number of vascular complications associated with electrophysiological procedures and the increasing evidence to support its use in electrophysiology, ultrasound remains underutilised. A new standard of care is required. A comprehensive technical report, providing a detailed explanation of this important technique, will provide other electrophysiology centres with the knowledge and justification for adopting ultrasound guidance as their standard practice. We review the increasing body of evidence which demonstrates that routine ultrasound usage can substantially improve the safety of femoral venous access in the electrophysiology laboratory. We offer a comprehensive technical report to guide operators through the process of ultrasound-guided venous access, with a specific focus on the electrophysiology laboratory. Additionally, we detail a novel technique which utilises real-time colour Doppler ultrasound to accurately identify needle tip location during venous puncture. The use of vascular ultrasound to guide femoral venous cannulation is rapid, inexpensive and easily learnt. Ultrasound is readily available and offers the potential to significantly reduce vascular complications in the unique setting of the electrophysiology laboratory. Ultrasound guidance to achieve femoral venous access should be the new standard of care in electrophysiology.

  10. Evolution of the NWC (Naval Weapons Center) Thermal Standard. Part 5. Summary: Thermal Standard Development and Applications.

    DTIC Science & Technology

    1984-07-01

    release; distribution unlimited. + C-) DTIFC 0 1 6 98 V. E 84 09 28 002 I. 7777 Naval Weapons Center AN ACTVITY OF THE NAVAL MATERIAL COMMAND FOREWORD...Combining these with other size considerations, a 6-inch diameter was chosen to satisfy all criteria. Materials The choice of materials used in the thermal...aluminum) shell surrounding a volume of propellant, explosive, air, or electronics. The inside material usually has a low thermal conductivity and may

  11. The Data Acquisition and Control Systems of the Jet Noise Laboratory at the NASA Langley Research Center

    NASA Technical Reports Server (NTRS)

    Jansen, B. J., Jr.

    1998-01-01

    The features of the data acquisition and control systems of the NASA Langley Research Center's Jet Noise Laboratory are presented. The Jet Noise Laboratory is a facility that simulates realistic mixed flow turbofan jet engine nozzle exhaust systems in simulated flight. The system is capable of acquiring data for a complete take-off assessment of noise and nozzle performance. This paper describes the development of an integrated system to control and measure the behavior of model jet nozzles featuring dual independent high pressure combusting air streams with wind tunnel flow. The acquisition and control system is capable of simultaneous measurement of forces, moments, static and dynamic model pressures and temperatures, and jet noise. The design concepts for the coordination of the control computers and multiple data acquisition computers and instruments are discussed. The control system design and implementation are explained, describing the features, equipment, and the experiences of using a primarily Personal Computer based system. Areas for future development are examined.

  12. A Review of the Centers for Disease Control and Prevention's Guidelines for the Clinical Laboratory Diagnosis of Lyme Disease.

    PubMed

    Miraglia, Caterina M

    2016-12-01

    The purpose of this paper is to review information regarding the current guidelines for the clinical laboratory diagnosis of Lyme disease as set forth by the Centers for Disease Control and Prevention (CDC) to chiropractic physicians and to discuss the clinical utility of this testing. The CDC's website was reviewed to determine what their current recommendations are for the clinical laboratory testing of Lyme disease. The CDC's established guidelines recommend the use of a 2-tiered serologic testing algorithm for the evaluation of patients with suspected Lyme disease. This review provides doctors of chiropractic with information to remain current with the CDC's recommended guidelines for Lyme disease testing because patients may present to their office with the associated signs and symptoms of Lyme disease.

  13. NASA Langley Research Center's Simulation-To-Flight Concept Accomplished through the Integration Laboratories of the Transport Research Facility

    NASA Technical Reports Server (NTRS)

    Martinez, Debbie; Davidson, Paul C.; Kenney, P. Sean; Hutchinson, Brian K.

    2004-01-01

    The Flight Simulation and Software Branch (FSSB) at NASA Langley Research Center (LaRC) maintains the unique national asset identified as the Transport Research Facility (TRF). The TRF is a group of facilities and integration laboratories utilized to support the LaRC's simulation-to-flight concept. This concept incorporates common software, hardware, and processes for both groundbased flight simulators and LaRC s B-757-200 flying laboratory identified as the Airborne Research Integrated Experiments System (ARIES). These assets provide Government, industry, and academia with an efficient way to develop and test new technology concepts to enhance the capacity, safety, and operational needs of the ever-changing national airspace system. The integration of the TRF enables a smooth continuous flow of the research from simulation to actual flight test.

  14. Part 1: Laboratory Culture of Centroptilum triangulifer (Ephemeroptera: BAETIDAE) Using a Standardized Diet of Three Diatoms.

    EPA Science Inventory

    Development of methods for assessing exposure and effects of waterborne toxicants on stream invertebrate species is important to elucidate environmentally relevant information. United States Environmental Protection Agency (USEPA) laboratory protocols for invertebrate toxicity te...

  15. Part 1: Laboratory Culture of Centroptilum triangulifer (Ephemeroptera: BAETIDAE) Using a Standardized Diet of Three Diatoms.

    EPA Science Inventory

    Development of methods for assessing exposure and effects of waterborne toxicants on stream invertebrate species is important to elucidate environmentally relevant information. United States Environmental Protection Agency (USEPA) laboratory protocols for invertebrate toxicity te...

  16. Hyperspectral Remote Sensing and Ecological Modeling Research and Education at Mid America Remote Sensing Center (MARC): Field and Laboratory Enhancement

    NASA Technical Reports Server (NTRS)

    Cetin, Haluk

    1999-01-01

    The purpose of this project was to establish a new hyperspectral remote sensing laboratory at the Mid-America Remote sensing Center (MARC), dedicated to in situ and laboratory measurements of environmental samples and to the manipulation, analysis, and storage of remotely sensed data for environmental monitoring and research in ecological modeling using hyperspectral remote sensing at MARC, one of three research facilities of the Center of Reservoir Research at Murray State University (MSU), a Kentucky Commonwealth Center of Excellence. The equipment purchased, a FieldSpec FR portable spectroradiometer and peripherals, and ENVI hyperspectral data processing software, allowed MARC to provide hands-on experience, education, and training for the students of the Department of Geosciences in quantitative remote sensing using hyperspectral data, Geographic Information System (GIS), digital image processing (DIP), computer, geological and geophysical mapping; to provide field support to the researchers and students collecting in situ and laboratory measurements of environmental data; to create a spectral library of the cover types and to establish a World Wide Web server to provide the spectral library to other academic, state and Federal institutions. Much of the research will soon be published in scientific journals. A World Wide Web page has been created at the web site of MARC. Results of this project are grouped in two categories, education and research accomplishments. The Principal Investigator (PI) modified remote sensing and DIP courses to introduce students to ii situ field spectra and laboratory remote sensing studies for environmental monitoring in the region by using the new equipment in the courses. The PI collected in situ measurements using the spectroradiometer for the ER-2 mission to Puerto Rico project for the Moderate Resolution Imaging Spectrometer (MODIS) Airborne Simulator (MAS). Currently MARC is mapping water quality in Kentucky Lake and

  17. Creating 21st-Century Laboratories and Classrooms for Improving Population Health: A Call to Action for Academic Medical Centers.

    PubMed

    DeVoe, Jennifer E; Likumahuwa-Ackman, Sonja; Shannon, Jackilen; Steiner Hayward, Elizabeth

    2017-04-01

    Academic medical centers (AMCs) in the United States built world-class infrastructure to successfully combat disease in the 20th century, which is inadequate for the complexity of sustaining and improving population health. AMCs must now build first-rate 21st-century infrastructure to connect combating disease and promoting health. This infrastructure must acknowledge the bio-psycho-social-environmental factors impacting health and will need to reach far beyond the AMC walls to foster community "laboratories" that support the "science of health," complementary to those supporting the "science of medicine"; cultivate community "classrooms" to stimulate learning and discovery in the places where people live, work, and play; and strengthen bridges between academic centers and these community laboratories and classrooms to facilitate bidirectional teaching, learning, innovation, and discovery.Private and public entities made deep financial investments that contributed to the AMC disease-centered approach to clinical care, education, and research in the 20th century. Many of these same funders now recognize the need to transform U.S. health care into a system that is accountable for population health and the need for a medical workforce equipped with the skills to measure and improve health. Innovative ideas about communities as centers of learning, the importance of social factors as major determinants of health, and the need for multidisciplinary perspectives to solve complex problems are not new; many are 20th-century ideas still waiting to be fully implemented. The window of opportunity is now. The authors articulate how AMCs must take bigger and bolder steps to become leaders in population health.

  18. From Topos to Oikos: The Standardization of Glass Containers as Epistemic Boundaries in Modern Laboratory Research (1850-1900).

    PubMed

    Espahangizi, Kijan

    2015-09-01

    Glass vessels such as flasks and test tubes play an ambiguous role in the historiography of modern laboratory research. In spite of the strong focus on the role of materiality in the last decades, the scientific glass vessel - while being symbolically omnipresent - has remained curiously neglected in regard to its materiality. The popular image or topos of the transparent, neutral, and quasi-immaterial glass container obstructs the view of the physico-chemical functionality of this constitutive inner boundary in modern laboratory environments and its material historicity. In order to understand how glass vessels were able to provide a stable epistemic containment of spatially enclosed experimental phenomena in the new laboratory ecologies emerging in the nineteenth and early twentieth century, I will focus on the history of the material standardization of laboratory glassware. I will follow the rise of a new awareness for measurement errors due to the chemical agency of experimental glass vessels, then I will sketch the emergence of a whole techno-scientific infrastructure for the improvement of glass container quality in late nineteenth-century Germany. In the last part of my argument, I will return to the laboratory by looking at the implementation of this glass reform that created a new oikos for the inner experimental milieus of modern laboratory research.

  19. Safety Basis Requirements for Nonnuclear Facilities at Lawrence Livermore National Laboratory Site-Specific Work Smart Standards Revision 1

    SciTech Connect

    Beach, R; Brereton, S; Failor, R; Hildum, S; Spagnolo, S; Van Warmerdam, C

    2003-02-24

    This standard establishes requirements that, when coupled with Lawrence Livermore National Laboratory's (LLNL's) Integrated Safety Management System (ISMS) methods and other Work Smart Standards for assuring worker safety, assure that the impacts of nonnuclear operations authorized in LLNL facilities are well understood and controlled in a manner that protects the health of workers, the public, and the environment. All LLNL facilities shall be classified based on potential for adverse impact of operations to the health of co-located (i.e., nearby) workers and the public in accordance with this standard, Title 10 Code of Federal Regulations (10 CFR) 830, Subpart B, and Department of Energy Order (DOE O) 420.2A. This standard provides information on: Objectives; Applicability; Safety analysis requirements; Control selection and maintenance; Documentation requirements; Safety basis review, approval, and renewal; and Safety basis implementation.

  20. Deedee Montzka of the National Center for Atmospheric Research checks out the NOxyO3 instrument on NASA's DC-8 flying laboratory before the ARCTAS mission

    NASA Image and Video Library

    2008-03-07

    Climate researchers from the National Center for Atmospheric Research (NCAR) and several universities install and perform functional checkouts of a variety of sensitive atmospheric instruments on NASA's DC-8 airborne laboratory prior to beginning the ARCTAS mission.

  1. DC-8 Airborne Laboratory in flight over NASA Dryden center with SCA 747 on ramp

    NASA Technical Reports Server (NTRS)

    1998-01-01

    The DC-8 aircraft is seen making a banking turn high above the NASA Dryden ramp. This view of the DC-8's left side reveals some of the modifications necessary for particular on-board experiments. To the right of the DC-8 is the edge of Rogers Dry Lake. Above the aircraft's forward fuselage is the Dryden Flight Research Center headquarters building, while other NASA facilities extend down the flightline to the right. Below the DC-8 is the Shuttle Carrier Aircraft (SCA), on which are visible attachment points for the Shuttle Orbiter.

  2. FAA Airworthiness Assurance NDI Validation Center (AANC) operated by Sandia National Laboratories.

    SciTech Connect

    Roach, Dennis Patrick; Hartman, Roger D.

    2010-09-01

    Airworthiness Assurance NDI Validation Center (AANC) objectives are: (1) Enhance aircraft safety and reliability; (2) Aid developing advanced aircraft designs and maintenance techniques; (3) Provide our customers with comprehensive, independent, and quantitative/qualitative evaluations of new and enhanced inspection, maintenance, and repair techniques; (4) Facilitate transferring effective technologies into the aviation industry; (5) Support FAA rulemaking process by providing guidance on content & necessary tools to meet requirements or recommendations of FARs, ADs, ACs, SBs, SSIDs, CPCP, and WFD; and (6) Coordinate with and respond to Airworthiness Assurance Working Group (AAWG) in support of FAA Aviation Rulemaking Advisory Committee (ARAC).

  3. Spectral Irradiance Calibration in the Infrared 11: Comparison of (alpha) Boo and 1 Ceres with a Laboratory Standard

    NASA Technical Reports Server (NTRS)

    Witteborn, Fred C.; Cohen, Martin; Bregman, Jess D.; Wooden, Diane; Heere, Karen; Shirley, Eric L.

    1998-01-01

    Infrared spectra of two celestial objects frequently used as flux standards are calibrated against an absolute laboratory flux standard at a spectral resolving power of 100 to 200. The spectrum of the K1.5III star, alpha Boo, is measured from 3 microns to 30 microns and that of the C-type asteroid, 1 Ceres, from 5 microns to 30 microns. While these 'standard' spectra do not have the apparent precision of those based on calculated models, they do not require the assumptions involved in theoretical models of stars and asteroids. Specifically they provide a model-independent means of calibrating celestial flux in the spectral range from 12 microns to 30 microns where accurate absolute photometry is not available. The agreement found between the spectral shapes of alpha Boo and Ceres based on laboratory standards, and those based on observed ratios to alpha CMa (Sirius) and alpha Lyr (Vega), flux calibrated by theoretical modeling of these hot stars strengthens our confidence in the applicability of the stellar models as primary irradiance standards.

  4. Spectral Irradiance Calibration in the Infrared. 11; Comparison of (alpha) Bootis and 1 Ceres with a Laboratory Standard

    NASA Technical Reports Server (NTRS)

    Witteborn, Fred C.; Cohen, Martin; Bregman, Jesse D.; Wooden, Diane H.; Heere, Karen; Shirley, Eric L.

    1999-01-01

    Infrared spectra of two celestial objects frequently used as flux standards are calibrated against an absolute laboratory flux standard at a spectral resolving power of 100 to 200. The spectrum of the KI.5 III star alpha Boo is measured from 3 to 30 microns, and that of the C-type asteroid 1 Ceres from 5 to 30 microns. While these "standard" spectra do not have the apparent precision of those based on calculated models, they do not require the assumptions involved in theoretical models of stars and asteroids. Specifically, they provide a model-independent means of calibrating celestial flux in the spectral range from 12 to 30 microns, where accurate absolute photometry is not available. The agreement found between the spectral shapes of alpha Boo and Ceres based on laboratory standards and those based on observed ratios to alpha CMa (Sirius) and alpha Lyr (Vega), flux-calibrated by theoretical modeling of these hot stars, strengthens our confidence in the applicability of the stellar models as primary irradiance standards.

  5. National Crime Information Center Mandatory Minimum Standards Curriculum for Full Access Terminal Operators. Volume Two--NCIC "Hot" Files.

    ERIC Educational Resources Information Center

    Federal Bureau of Investigation, Washington, DC. National Crime Information Center.

    This document is the second volume of a two-volume set of lesson plans that together make up a complete training package for full-service terminal operators. The lesson plans are designed to ensure that a state's National Crime Information Center (NCIC) training program meets Advisory Policy Board standards. (NCIC is a nationwide computerized…

  6. Time and Frequency Activities at the Lithuanian National Time Standard Laboratory

    DTIC Science & Technology

    2007-11-01

    4] "Time stamping profile," ETSI TS 101 861 v1.3.1 (European Telecommunications Standard Institute, Sophia Antipolis Cedex, France), 2006. [5...102 023 v1.2.1 (European Telecommunications Standard Institute, Sophia Antipolis Cedex, France), 2003. 147 39th Annual Precise Time and Time Interval (PTTI) Meeting 148

  7. Standard testing procedures for optical fiber and unshielded twisted pair at Sandia National Laboratories

    SciTech Connect

    Adams, R.L.

    1993-11-01

    This document will establish a working standard for testing optical fiber and unshielded twisted pair cables included in the Lab-wide telecommunications cabling system. The purpose of these standard testing procedures is to deliver to all Sandians a reliable, low-maintenance, state-of-the-art, ubiquitous telecommunications cabling infrastructure capable of satisfying all current and future telecommunication needs.

  8. Standard testing procedures for optical fiber and unshielded twisted pair at Sandia National Laboratories. Revision

    SciTech Connect

    Adams, R.L.

    1994-09-01

    This revision updates Sandia`s working standard for testing optical fiber and unshielded twisted pair cables included in the Lab-wide telecommunications cabling infrastructure. The purpose of these standard testing procedures is to deliver to all Sandians a reliable, low-maintenance, state-of-the-art, ubiquitous telecommunications cabling infrastructure capable of satisfying all current and future telecommunication needs.

  9. The World Health Organization's role and future plans in laboratory standardization.

    PubMed

    Heuck, C C

    1993-01-01

    WHO is monitoring health care and the status of health of the population in each of its member states. The statistics provides valuable information for the comparison of the effectiveness of different health systems. As part of its global responsibility on health WHO issues international reference materials (IRMs), assigns international nonproprietary names for therapeutics (INNs), publishes guidelines for good manufacturing practice (GMP) and good laboratory practice (GLP) and, in collaboration with international professional organizations, makes recommendations towards achieving global harmonization of clinical laboratory investigations.

  10. Competency assessment in laboratory medicine: Standardization and utility for technical staff assessment and recertification in Saudi Arabia.

    PubMed

    Nemenqani, Dalal M; Tekian, Ara; Park, Yoon Soo

    2017-04-01

    licensure in sample laboratories in Saudi Arabia. The program will be monitored and evaluated during and after implementation for processes and outcomes. Conclusions will be utilized for national competency program. This study represents an important step towards the implementation of a standardized laboratory competence assessment program at a national level.

  11. Retrofitting Laboratory Fume Hoods With Face Velocity Monitors at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Wagner, Ingrid E.; Bold, Margaret D.; Diamond, David B.; Kall, Phillip M.

    1997-01-01

    Extensive use and reliance on laboratory fume hoods exist at LeRC for the control of chemical hazards (nearly 175 fume hoods). Flow-measuring devices are necessary to continually monitor hood performance. The flow-measuring device should he tied into an energy management control system to detect problems at a central location without relying on the users to convey information of a problem. Compatibility concerns and limitations should always be considered when choosing the most effective flow-measuring device for a particular situation. Good practice on initial hood design and placement will provide a system for which a flow-measuring device may be used to its full potential and effectiveness.

  12. Retrofitting Laboratory Fume Hoods With Face Velocity Monitors at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Wagner, Ingrid E.; Bold, Margaret D.; Diamond, David B.; Kall, Phillip M.

    1997-01-01

    Extensive use and reliance on laboratory fume hoods exist at LeRC for the control of chemical hazards (nearly 175 fume hoods). Flow-measuring devices are necessary to continually monitor hood performance. The flow-measuring device should he tied into an energy management control system to detect problems at a central location without relying on the users to convey information of a problem. Compatibility concerns and limitations should always be considered when choosing the most effective flow-measuring device for a particular situation. Good practice on initial hood design and placement will provide a system for which a flow-measuring device may be used to its full potential and effectiveness.

  13. Fitness components of Drosophila melanogaster developed on a standard laboratory diet or a typical natural food source.

    PubMed

    Kristensen, Torsten Nygaard; Henningsen, Astrid Kallestrup; Aastrup, Christian; Bech-Hansen, Mads; Bjerre, Lise B Hoberg; Carlsen, Benjamin; Hagstrup, Marie; Jensen, Sofie Graarup; Karlsen, Pernille; Kristensen, Line; Lundsgaard, Cecillie; Møller, Tine; Nielsen, Lise D; Starcke, Camilla; Sørensen, Christine Riisager; Schou, Mads Fristrup

    2016-10-01

    Drosophila melanogaster is often used as a model organism in evolutionary biology and ecophysiology to study evolutionary processes and their physiological mechanisms. Diets used to feed Drosophila cultures differ between laboratories and are often nutritious and distinct from food sources in the natural habitat. Here we rear D. melanogaster on a standard diet used in our laboratory and a field diet composed of decomposing apples collected in the field. Flies developed on these two diet compositions are tested for heat, cold, desiccation, and starvation resistance as well as developmental time, dry body mass and fat percentage. The nutritional compositions of the standard and field diets were analyzed, and discussed in relation to the phenotypic observations. Results showed marked differences in phenotype of flies from the two types of diets. Flies reared on the field diet are more starvation resistant and they are smaller, leaner, and have lower heat resistance compared to flies reared on the standard diet. Sex specific effects of diet type are observed for several of the investigated traits and the strong sexual dimorphism usually observed in desiccation resistance in D. melanogaster disappeared when rearing the flies on the field diet. Based on our results we conclude that care should be taken in extrapolating results from one type of diet to another and especially from laboratory to field diets.

  14. Estimation of Wildlife Hazard Levels Using Interspecies Correlation Models and Standard Laboratory Rodent Toxicity Data

    EPA Science Inventory

    Toxicity data from laboratory rodents are widely available and frequently used in human health assessments as an animal model. We explore the possibility of using single rodent acute toxicity values to predict chemical toxicity to a diversity of wildlife species and to estimate ...

  15. Estimation of Wildlife Hazard Levels Using Interspecies Correlation Models and Standard Laboratory Rodent Toxicity Data

    EPA Science Inventory

    Toxicity data from laboratory rodents are widely available and frequently used in human health assessments as an animal model. We explore the possibility of using single rodent acute toxicity values to predict chemical toxicity to a diversity of wildlife species and to estimate ...

  16. Cellular Cultivation: Growing HeLa Cells Using Standard High School Laboratory Equipment.

    ERIC Educational Resources Information Center

    Woloschak, Gayle; And Others

    1995-01-01

    Describes experiments to culture cells in a laboratory that provide students with hands-on experience in manipulating cells and a chance to observe cell growth characteristics first hand. Exposes students to sterile technique, cell culture, cell growth concepts, and eukaryotic cell structure. (JRH)

  17. Implementation of ISO guide 25 in a medical dosimetry secondary standards calibration laboratory

    SciTech Connect

    DeWerd, L.A.

    1995-12-31

    Currently, there is a great deal of discussion among industry and government agencies about ISO 9000 accreditation. U.S. manufacturers with ISO 9000 accreditation are regarded more favorably by European countries. The principles behind the ISO 9000 accreditation are based on the Total Quality Management (TQM) principles that are being implemented in many U.S. industries. This paper will deal only with the calibration issue. There is a difference in the areas covered by ISO 9000 and ISO Guide 25 documents. ISO 9000, in particular ISO 9001 - ISO 9003, cover the {open_quotes}calibration{close_quotes} of inspection, measuring and test equipment. This equipment is basically used for {open_quotes}factory calibrations{close_quotes} to determine that equipment is performing within manufacturer specifications. ISO Guide 25 is specifically for {open_quotes}calibration and testing laboratories,{close_quotes} generally laboratories that have painstaking procedures to reduce uncertainties and establish high accuracy of the transfer of calibration. The experience of the University of Wisconsin Accredited Dosimetry Calibration Laboratory in conforming to ISO Guide 25 will be outlined. The entire laboratory staff must become familiar with the process and an individual with direct authority must become the one to maintain the quality of equipment and calibrations in the role of {open_quotes}quality-assurance manager.{close_quotes}

  18. Allied Health Occupations II. Medical Laboratory Assistant Component. Student Learning Guide. Middletown Public Schools Curriculum Standards.

    ERIC Educational Resources Information Center

    Middletown Public Schools, CT.

    This volume outlines the requirements and content of a second-year course in allied health occupations education that is intended to provide students with a practical understanding of the work done by medical laboratory technicians and technologists. Addressed in the individual units of the course are the following topics: the value of…

  19. Cellular Cultivation: Growing HeLa Cells Using Standard High School Laboratory Equipment.

    ERIC Educational Resources Information Center

    Woloschak, Gayle; And Others

    1995-01-01

    Describes experiments to culture cells in a laboratory that provide students with hands-on experience in manipulating cells and a chance to observe cell growth characteristics first hand. Exposes students to sterile technique, cell culture, cell growth concepts, and eukaryotic cell structure. (JRH)

  20. Allied Health Occupations II. Medical Laboratory Assistant Component. Student Learning Guide. Middletown Public Schools Curriculum Standards.

    ERIC Educational Resources Information Center

    Middletown Public Schools, CT.

    This volume outlines the requirements and content of a second-year course in allied health occupations education that is intended to provide students with a practical understanding of the work done by medical laboratory technicians and technologists. Addressed in the individual units of the course are the following topics: the value of…

  1. [Control of accuracy of immunoserological laboratory data on medical network and standardization].

    PubMed

    Konishi, Keiko

    2003-05-01

    Construction of a medical network for each region and organization has become possible by utilization of information technology. Standardization of the data on the medical network is urgent. Especially, the standardization of immunoserological data is much delayed. In this study, the possibility of standardization of such data was reconsidered based on the findings from various control surveys. Regarding the measurement items for serum concentrations of proteins and other compounds, we concluded that standardization should occur in a manner similar to the method for standardization of biochemical data and accurate control. The data on CRP, IgG, IgA, IgM and AFP, which are determined using the respective standard compound, were converged to a range with inter-facility differences of less than 10% CV. The data on CEA were also converged to achieve an inter-facility difference of less than 10% CV through repeated survey. Automatic measurement for the markers of infection diseases has progressed, and the expression of measurements was changed to the absolute value of COI, U/ml or IU/ml although it was titer in the past. Since these expressions now coexist, it is impossible to standardize the data with absolute qualitative values. It seemed necessary to present them uniformly with qualitative or clinical criteria values or express the presence or absence of infection by a combination of related markers. The measurements obtained from autoantibody-related tests using identical reagent were found coincident, but measurements obtained using different reagents were discrepant and the differences were greater than the sensitivity of measurement. In immunoserological testing and immunochemical testing, it is most important whether the antigen/antibody used as the reagent is the same preparation or not. Therefore, the test should be reconsidered through setting a certain restrictions on each recognition site of epitope and antibody. Thus, we concluded that use of a suitable

  2. 78 FR 42084 - Electronic Study Data Submission; Data Standard Support; Availability of the Center for Drug...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-15

    ... HUMAN SERVICES Food and Drug Administration Electronic Study Data Submission; Data Standard Support... Strategy (version 1.0) and the CDER Data Standards Strategy--Action Plan (version 1.0). This action is... CDER Data Standards Strategy (version 1.0) was released. Its purpose is to reinforce FDA's ongoing...

  3. CTEPP STANDARD OPERATING PROCEDURE FOR DAY CARE CENTER SAMPLE SUBJECTS RECRUITMENT (SOP-1.11)

    EPA Science Inventory

    The CTEPP subject recruitment procedures for the daycare center component are described in the SOP. There are two stages in this phase of CTEPP subject recruitment. The objective of the first stage is to enroll daycare centers for the study. Six target counties in each state ar...

  4. CTEPP STANDARD OPERATING PROCEDURE FOR DAY CARE CENTER SAMPLE SUBJECTS RECRUITMENT (SOP-1.11)

    EPA Science Inventory

    The CTEPP subject recruitment procedures for the daycare center component are described in the SOP. There are two stages in this phase of CTEPP subject recruitment. The objective of the first stage is to enroll daycare centers for the study. Six target counties in each state ar...

  5. The impact of standard preparation practice on the runoff and soil erosion rates under laboratory conditions

    NASA Astrophysics Data System (ADS)

    Khaledi Darvishan, Abdulvahed; Homayounfar, Vafa; Hamidreza Sadeghi, Seyed

    2016-09-01

    The use of laboratory methods in soil erosion studies, rainfall simulation experiments, Gerlach troughs, and other measurements such as ring infiltrometer has been recently considered more and more because of many advantages in controlling rainfall properties and high accuracy of sampling and measurements. However, different stages of soil removal, transfer, preparation and placement in laboratory plots cause significant changes in soil structure and, subsequently, the results of runoff, sediment concentration and soil loss. Knowing the rate of changes in sediment concentration and soil loss variables with respect to the soil preparation for laboratory studies is therefore inevitable to generalize the laboratory results to field conditions. However, there has been little attention given to evaluate the effects of soil preparation on sediment variables. The present study was therefore conducted to compare sediment concentration and soil loss in natural and prepared soil. To achieve the study purposes, 18 field 1 × 1 m plots were adopted in an 18 % gradient slope with sandy-clay-loam soil in the Kojour watershed, northern Iran. A portable rainfall simulator was then used to simulate rainfall events using one or two nozzles of BEX: 3/8 S24W for various rainfall intensities with a constant height of 3 m above the soil surface. Three rainfall intensities of 40, 60 and 80 mm h-1 were simulated on both prepared and natural soil treatments with three replications. The sediment concentration and soil loss at five 3 min intervals after time to runoff were then measured. The results showed the significant increasing effects of soil preparation (p ≤ 0.01) on the average sediment concentration and soil loss. The increasing rates of runoff coefficient, sediment concentration and soil loss due to the study soil preparation method for laboratory soil erosion plots were 179, 183 and 1050 % (2.79, 2.83 and 11.50 times), respectively.

  6. Implementation of the OECD principles of good laboratory practice in test facilities complying with a quality system accredited to the ISO/IEC 17025 standard.

    PubMed

    Feller, Etty

    2008-01-01

    Laboratories with a quality system accredited to the ISO/IEC 17025 standard have a definite advantage, compared to non-accredited laboratories, when preparing their facilities for the implementation of the principles of good laboratory practice (GLP) of the Organisation for Economic Co-operation and Development (OECD). Accredited laboratories have an established quality system covering the administrative and technical issues specified in the standard. The similarities and differences between the ISO/IEC 17025 standard and the OECD principles of GLP are compared and discussed.

  7. Analysis of the Quality of Research and Development at the OERI Research and Development Centers and at the OERI Regional Educational Laboratories.

    ERIC Educational Resources Information Center

    Vinovskis, Maris A.

    An evaluation of the Research and Development Centers and the Regional Educational Laboratories of the Office of Educational Research and Improvement (OERI) was conducted by an outside analyst brought in in September 1991 by then Assistant Secretary Diane Ravitch. The Research and Development Centers have been one of the primary sources of…

  8. Recent Improvements to the Acoustical Testing Laboratory at the NASA Glenn Research Center

    NASA Technical Reports Server (NTRS)

    Podboy, Devin M.; Mirecki, Julius H.; Walker, Bruce E.; Sutliff, Daniel L.

    2014-01-01

    The Acoustical Testing Laboratory (ATL) consists of a 27- by 23- by 20-ft (height) convertible hemi/anechoic chamber and separate sound-attenuating test support enclosure. Absorptive fiberglass wedges in the test chamber provide an anechoic environment down to 100 Hz. A spring-isolated floor system affords vibration isolation above 3 Hz. These specifications, along with very low design background levels, enable the acquisition of accurate and repeatable acoustical measurements on test articles that produce very low sound pressures. Removable floor wedges allow the test chamber to operate in either a hemi-anechoic or anechoic configuration, depending on the size of the test article and the specific test being conducted. The test support enclosure functions as a control room during normal operations. Recently improvements were accomplished in support of continued usage of the ATL by NASA programs including an analysis of the ultra-sonic characteristics. A 3-D traverse system inside the chamber was utilized for acquiring acoustic data for these tests. The traverse system drives a linear array of 13, 1/4 in.-microphones spaced 3 in. apart (36 in. span). An updated data acquisition system was also incorporated into the facility.

  9. Recent Improvements to the Acoustical Testing Laboratory at the NASA Glenn Research Center

    NASA Technical Reports Server (NTRS)

    Podboy, Devin M.; Mirecki, Julius H.; Walker, Bruce E.; Sutliff, Daniel L.

    2014-01-01

    The Acoustical Testing Laboratory (ATL) consists of a 27 by 23 by 20 ft (height) convertible hemi/anechoic chamber and separate sound-attenuating test support enclosure. Absorptive fiberglass wedges in the test chamber provide an anechoic environment down to 100 Hz. A spring-isolated floor system affords vibration isolation above 3 Hz. These specifications, along with very low design background levels, enable the acquisition of accurate and repeatable acoustical measurements on test articles that produce very low sound pressures. Removable floor wedges allow the test chamber to operate in either a hemi-anechoic or anechoic configuration, depending on the size of the test article and the specific test being conducted. The test support enclosure functions as a control room during normal operations. Recently improvements were accomplished in support of continued usage of the ATL by NASA programs including an analysis of the ultra-sonic characteristics. A 3 dimensional traverse system inside the chamber was utilized for acquiring acoustic data for these tests. The traverse system drives a linear array of 13, 1/4"-microphones spaced 3" apart (36" span). An updated data acquisition system was also incorporated into the facility.

  10. The compliance of licensed US child care centers with national health and safety performance standards.

    PubMed Central

    Addiss, D G; Sacks, J J; Kresnow, M J; O'Neil, J; Ryan, G W

    1994-01-01

    The American Public Health Association and the American Academy of Pediatrics recently published health and safety guidelines for child care centers. A survey was conducted to determine the extent to which practices in US child care centers are reflective of these guidelines. Compliance with 16 guidelines ranged from 19.5% to 98.6%, varied considerably by state, and was not consistently associated with selected center characteristics. Prevention efforts should focus on practices for which compliance is low and on those that have the greatest disease- and injury-reducing potential. PMID:8017546

  11. Virtual Global Transplant Laboratory Standard Operating Protocol for Donor Alloantigen-specific Interferon-gamma ELISPOT Assay

    PubMed Central

    Carroll, Robert; Troelnikov, Alexander; Chong, Anita S.

    2016-01-01

    Abstract The quantification of frequency of IFN-γ–producing T cells responding to donor alloantigen using the IFN-γ enzyme linked immunosorbent spot (ELISPOT) holds potential for pretransplant and posttransplant immunological risk stratification. The effectiveness of this assay, and the ability to compare results generated by different studies, is dependent on the utilization of a standardized operating procedure (SOP). Key factors in assay standardization include the identification of primary and secondary antibody pairs, and the reading of the ELISPOT plate with a standardized automated algorithm. Here, we describe in detail, an SOP that should provide low coefficient of variation results. For multicenter trials, it is recommended that groups perform the ELISPOT assays locally but use a centralized ELISPOT reading facility, as this has been shown to be beneficial in reducing coefficient of variation between laboratories even when the SOP is strictly adhered to. PMID:27826604

  12. Jet Propulsion Laboratory/Kennedy Space Center telerobotic inspection and manipulation demonstration

    NASA Technical Reports Server (NTRS)

    Wilcox, Brian; Davis, Leon

    1990-01-01

    The goal of this effort is to demonstrate telerobotic inspection and mainpulation of space shuttle payloads in the presence of substantial communications time delays between the operator station and the robotic work space. The processing of space shuttle payloads provides a variety of tasks which are typical of both space shuttle ground operations and Space Station in-flight operations, and communications time delays are inevitable in space operations where the operator station will be light-seconds away from the telerobot. With this demonstration we hope to show the efficacy and safety of robotic technology for ground and space operations. Our approach is to develop an experimental telerobotic system with the remote sensing, actuation and reflex portions located at KSC in Florida, while the operator control station will be located at Jet Propulsion Laboratory (JPL) in California. The JPL portion of the system includes a high-level operator interface, intelligent spatial planning and machine vision, while the KSC portion includes the robot arm, end effectors, cameras and proximity sensors, and the necessary control and communications computers and software. The communications between JPL and KSC are over a limited-bandwidth network channel (19200 baud) with unpredictable and unrepeatable time delays. In FY89 we integrated a basic version of the robotic, communications, and computer hardware, and we developed the software to perform an operator-supervised inspection of a PAM-D satellite upper stage rocket motor and its shuttle support cradle. The demonstration, though severely limited by the bulk of the available computer arm, showed the potential of telerobotics for inspection tasks. In the future, we plan to develop additional capabilities which will allow manipulation tasks to be performed, including removal of dust covers and lens caps, insertion of connectors and batteries, and installation of payload objects.

  13. Standard-based comprehensive detection of adverse drug reaction signals from nursing statements and laboratory results in electronic health records.

    PubMed

    Lee, Suehyun; Choi, Jiyeob; Kim, Hun-Sung; Kim, Grace Juyun; Lee, Kye Hwa; Park, Chan Hee; Han, Jongsoo; Yoon, Dukyong; Park, Man Young; Park, Rae Woong; Kang, Hye-Ryun; Kim, Ju Han

    2017-07-01

    We propose 2 Medical Dictionary for Regulatory Activities-enabled pharmacovigilance algorithms, MetaLAB and MetaNurse, powered by a per-year meta-analysis technique and improved subject sampling strategy. This study developed 2 novel algorithms, MetaLAB for laboratory abnormalities and MetaNurse for standard nursing statements, as significantly improved versions of our previous electronic health record (EHR)-based pharmacovigilance method, called CLEAR. Adverse drug reaction (ADR) signals from 117 laboratory abnormalities and 1357 standard nursing statements for all precautionary drugs ( n   = 101) were comprehensively detected and validated against SIDER (Side Effect Resource) by MetaLAB and MetaNurse against 11 817 and 76 457 drug-ADR pairs, respectively. We demonstrate that MetaLAB (area under the curve, AUC = 0.61 ± 0.18) outperformed CLEAR (AUC = 0.55 ± 0.06) when we applied the same 470 drug-event pairs as the gold standard, as in our previous research. Receiver operating characteristic curves for 101 precautionary terms in the Medical Dictionary for Regulatory Activities Preferred Terms were obtained for MetaLAB and MetaNurse (0.69 ± 0.11; 0.62 ± 0.07), which complemented each other in terms of ADR signal coverage. Novel ADR signals discovered by MetaLAB and MetaNurse were successfully validated against spontaneous reports in the US Food and Drug Administration Adverse Event Reporting System database. The present study demonstrates the symbiosis of laboratory test results and nursing statements for ADR signal detection in terms of their system organ class coverage and performance profiles. Systematic discovery and evaluation of the wide spectrum of ADR signals using standard-based observational electronic health record data across many institutions will affect drug development and use, as well as postmarketing surveillance and regulation.

  14. Clinical and laboratory profile of primary hyperparathyroidism in Kashmir Valley: A single-center experience

    PubMed Central

    Misgar, Raiz Ahmad; Dar, Parvez Mohiuddin; Masoodi, Shariq Rashid; Ahmad, Munir; Wani, Khursheed Alam; Wani, Arshad Iqbal; Bashir, Mir Iftikhar

    2016-01-01

    Background: Although primary hyperparathyroidism (PHPT) has become an asymptomatic disease in the West, in India, PHPT is still an uncommonly diagnosed, overtly symptomatic disease with skeletal, muscular, and renal manifestations. Aims: To describe the profile and surgical outcome of 78 consecutive PHPT patients over a period of two decades at a single center. Materials and Methods: All patients who underwent evaluation and surgery for PHPT from January 1996 to December 2015 were included. Evaluation included measurement of serum total calcium, inorganic phosphorus, alkaline phosphatase, intact parathyroid hormone, 25-hydroxy Vitamin D, 24 hour urinary calcium and radiological survey. Ultrasonography neck and technetium-99m sestamibi scan were used for preoperative localization. Results: A total of 78 patients were identified during the two decades of whom 29 patients were studied retrospectively and 49 patients prospectively. Mean age of patients was 44.72 ± 12.46, and male:female ratio was 1:6. The most common presenting features were nephrolithiasis and/or nephrocalcinosis (64.10%), bone pain (44.1%), abdominal pain (39%), constipation (26%), and myopathy (14.10%). Fractures were present only in 10.25%, and brown tumors in 6.41% patients. The cure rate in our series was 96.15%. The mean parathyroid gland weight was 2.05 ± 3.03 g. None of the 41 patients in whom long-term follow-up was available, had recurrence of PHPT. Conclusions: The profile of PHPT is changing with older age at presentation, and emergence of renal stone disease and decline in overt skeletal disease as common presentation. The parathyroid weight in our study resembles that reported from developed countries. PMID:27730083

  15. Laboratory Instruments Available to Support Space Station Researchers at Marshall Space Flight Center

    NASA Technical Reports Server (NTRS)

    Panda, Binayak; Gorti, Sridhar

    2013-01-01

    A number of research instruments are available at NASA's Marshall Space Flight Center (MSFC) to support ISS researchers and their investigations. These modern analytical tools yield valuable and sometimes new informative resulting from sample characterization. Instruments include modern scanning electron microscopes equipped with field emission guns providing analytical capabilities that include angstron-level image resolution of dry, wet and biological samples. These microscopes are also equipped with silicon drift X-ray detectors (SDD) for fast yet precise analytical mapping of phases, as well as electron back-scattered diffraction (EBSD) units to map grain orientations in crystalline alloys. Sample chambers admit large samples, provide variable pressures for wet samples, and quantitative analysis software to determine phase relations. Advances in solid-state electronics have also facilitated improvements for surface chemical analysis that are successfully employed to analyze metallic materials and alloys, ceramics, slags, and organic polymers. Another analytical capability at MSFC is a mganetic sector Secondary Ion Mass Spectroscopy (SIMS) that quantitatively determines and maps light elements such as hydrogen, lithium, and boron along with their isotopes, identifies and quantifies very low level impurities even at parts per billion (ppb) levels. Still other methods available at MSFC include X-ray photo-electron spectroscopy (XPS) that can determine oxidation states of elements as well as identify polymers and measure film thicknesses on coated materials, Scanning Auger electron spectroscopy (SAM) which combines surface sensitivity, spatial lateral resolution (approximately 20 nm), and depth profiling capabilities to describe elemental compositions in near surface regions and even the chemical state of analyzed atoms. Conventional Transmission Electron Microscope (TEM) for observing internal microstructures at very high magnifications and the Electron Probe

  16. Detection of adeno- and lentiviral (HIV1) contaminations on laboratory surfaces as a tool for the surveillance of biosafety standards.

    PubMed

    Bagutti, C; Alt, M; Schmidlin, M; Vogel, G; Vögeli, U; Brodmann, P

    2011-07-01

    As a biosafety laboratory, we survey the handling of adenovirus type 5 (Ad5) and HIV1-derived lentivirus in contained-use facilities in Switzerland to identify insufficiencies of the safety precautions taken by the laboratories. In the past 9 years, we took 430 swab samples from various types of surfaces in research laboratories. Samples were examined for Ad5 contaminations by real-time PCR and infectivity assay or for the presence of lentivirus (HIV1) nucleic acids by real-time (RT) PCR. Samples collected from centrifuges did not only contain Ad5 DNA more frequently but also exhibited higher numbers of Ad5 and lentiviral (HIV1) DNA copies than swabs from any other area of sampling. Five of ten samples containing infectious Ad5 particles or lentivirus (HIV1) RNA were found in samples taken from centrifuges. Ad5 contamination rates were higher in the tube holder and lower on the inner wall of the rotor chamber in centrifuges that were fitted with aerosol tight covers compared to centrifuges without covers. Our results allowed the comparison of hygiene standards of different laboratories and lead to the identification of centrifuges as hotspots for contaminations. Based on our results, we propose to use the collected data as a tool for rating future swab results. Furthermore, the amount of Ad5 and HIV1-derived lentivirus DNA could serve as an indicator of the level of good laboratory practice in contained-use laboratories handling these viral vectors. © 2011 The Authors. Journal of Applied Microbiology © 2011 The Society for Applied Microbiology.

  17. Studying critical values: adverse event identification following a critical laboratory values study at the ohio state university medical center.

    PubMed

    Jenkins, James J; Mac Crawford, J; Bissell, Michael G

    2007-10-01

    No study to date has used laboratory critical values to evaluate variations in patient adverse events. We retrospectively analyzed a database of critical values to determine their distribution by hospital unit over time. The data were drawn from the Ohio State University Medical Center Information Warehouse (Columbus) for a 58-month period. Critical values were plotted over time on statistical control charts and analyzed for unusual peaks in monthly occurrence rates. Chart review of individual patient results yielded several predictor variables for the unusual peaks. Of these, occurrence of patient adverse events was the most relevant independent predictor variable for a month with an unusual number of critical values vs a normal month. This result epidemiologically confirms the basic premise of critical value reporting and suggests that the control-chart method of this type could be a new statistical tool to compare clinical activity of different hospital locations at different times.

  18. 40 CFR 79.60 - Good laboratory practices (GLP) standards for inhalation exposure health effects testing.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., scientific or academic establishment, government agency, or organizational unit thereof, and any other legal... for monitoring each study to assure management that the facilities, equipment, personnel, methods... describes the methods and standard operating procedures, and that the reported results accurately reflect...

  19. 40 CFR 79.60 - Good laboratory practices (GLP) standards for inhalation exposure health effects testing.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., scientific or academic establishment, government agency, or organizational unit thereof, and any other legal... for monitoring each study to assure management that the facilities, equipment, personnel, methods... describes the methods and standard operating procedures, and that the reported results accurately reflect...

  20. 40 CFR 79.60 - Good laboratory practices (GLP) standards for inhalation exposure health effects testing.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., scientific or academic establishment, government agency, or organizational unit thereof, and any other legal... for monitoring each study to assure management that the facilities, equipment, personnel, methods... describes the methods and standard operating procedures, and that the reported results accurately reflect...

  1. 40 CFR 79.60 - Good laboratory practices (GLP) standards for inhalation exposure health effects testing.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., scientific or academic establishment, government agency, or organizational unit thereof, and any other legal... for monitoring each study to assure management that the facilities, equipment, personnel, methods... describes the methods and standard operating procedures, and that the reported results accurately reflect...

  2. 76 FR 72216 - Occupational Exposure to Hazardous Chemicals in Laboratories Standard; Extension of the Office of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-22

    ... Request (ICR). All comments including any personal information you provide, are placed in the public... 1910, Subpart Z. They do so by developing a written Chemical Hygiene Plan (CHP) that describes standard... commenters about submitting personal information, such as social security numbers and dates of...

  3. 76 FR 25376 - Occupational Exposure to Hazardous Chemicals in Laboratories Standard; Extension of the Office of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-04

    ...-0059) for the Information Collection Request (ICR). All comments, including any personal information... by developing a written Chemical Hygiene Plan (CHP) that describes: Standard operating procedures for... commenters about submitting personal information such as Social Security Numbers and date of birth....

  4. Leishmania infection: laboratory diagnosing in the absence of a "gold standard".

    PubMed

    Rodríguez-Cortés, Alhelí; Ojeda, Ana; Francino, Olga; López-Fuertes, Laura; Timón, Marcos; Alberola, Jordi

    2010-02-01

    There is no gold standard for diagnosing leishmaniases. Our aim was to assess the operative validity of tests used in detecting Leishmania infection using samples from experimental infections, a reliable equivalent to the classic definition of gold standard. Without statistical differences, the highest sensitivity was achieved by protein A (ProtA), immunoglobulin (Ig)G2, indirect fluorescenece antibody test (IFAT), lymphocyte proliferation assay, quantitative real-time polymerase chain reaction of bone marrow (qPCR-BM), qPCR-Blood, and IgG; and the highest specificity by IgG1, IgM, IgA, qPCR-Blood, IgG, IgG2, and qPCR-BM. Maximum positive predictive value was obtained simultaneously by IgG2, qPCR-Blood, and IgG; and maximum negative predictive value by qPCR-BM. Best positive and negative likelihood ratios were obtained by IgG2. The test having the greatest, statistically significant, area under the receiver operating characteristics curve was IgG2 enzyme-linked immunosorbent assay (ELISA). Thus, according to the gold standard used, IFAT and qPCR are far from fulfilling the requirements to be considered gold standards, and the test showing the highest potential to detect Leishmania infection is Leishmania-specific ELISA IgG2.

  5. Vermont Core Standards and Self-Assessment Tool for Center-Based Early Childhood Programs.

    ERIC Educational Resources Information Center

    Vermont State Agency of Human Services, Waterbury.

    In response to the desire to create for child development services a unified system which shares common standards for quality and respects the diversity and uniqueness of individuals and of programs, a committee of the Early Childhood Work Group collected and compared all the different standards now in force for the early childhood programs in the…

  6. Naval Air Development Center Medical Standards for Research Subjects Exposed to Hazardous Aerospace Environments

    DTIC Science & Technology

    1991-02-01

    Postero-anterior and lateral chest radiographs and a complete anteroposterior and lateral spine (cervical, thoracic, and lumbar) radiographic series...certain congenital or acquired vertebral abnormalities, transitional vertebrae, and spina bifida occulta greater than one millimeter. In general, the...evaluation of the spine as described under Part II Centrifuge Acceleration Stress Medical Standards apply to ejection stress medical standards. NADC-91035

  7. 75 FR 56549 - National Center for Health Statistics (NCHS), Classifications and Public Health Data Standards...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-16

    ...), Classifications and Public Health Data Standards Staff, Announces the Following Meeting Name: ICD-9-CM... Administrator, Classifications and Public Health Data Standards Staff, NCHS, 3311 Toledo Road, Room 2337... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND...

  8. 76 FR 9018 - National Center for Health Statistics (NCHS), Classifications and Public Health Data Standards...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-16

    ...), Classifications and Public Health Data Standards Staff, Announces the Following Meeting Name: ICD-9-CM... Administrator, Classifications and Public Health Data Standards Staff, NCHS, 3311 Toledo Road, Room 2337... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND...

  9. 78 FR 53148 - National Center for Health Statistics (NCHS), Classifications and Public Health Data Standards...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-28

    ...), Classifications and Public Health Data Standards Staff, Announces the Following Meeting Name: ICD-9-CM..., Medical Systems Administrator, Classifications and Public Health Data Standards Staff, NCHS, 3311 Toledo... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND...

  10. 75 FR 39265 - National Center for Health Statistics (NCHS), Classifications and Public Health Data Standards...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-08

    ...), Classifications and Public Health Data Standards Staff, Announces the Following Meeting Name: ICD-9-CM... for Disease Control and Prevention, Classifications and Public Health Data Standards, 3311 Toledo Road... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND...

  11. 78 FR 9055 - National Center for Health Statistics (NCHS), Classifications and Public Health Data Standards...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-07

    ...), Classifications and Public Health Data Standards Staff, Announces the Following Meeting Name: ICD-9-CM... Information: Donna Pickett, Medical Systems Administrator, Classifications and Public Health Data Standards... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND...

  12. Comparison of a New Cobinamide-Based Method to a Standard Laboratory Method for Measuring Cyanide in Human Blood

    PubMed Central

    Swezey, Robert; Shinn, Walter; Green, Carol; Drover, David R.; Hammer, Gregory B.; Schulman, Scott R.; Zajicek, Anne; Jett, David A.; Boss, Gerry R.

    2013-01-01

    Most hospital laboratories do not measure blood cyanide concentrations, and samples must be sent to reference laboratories. A simple method is needed for measuring cyanide in hospitals. The authors previously developed a method to quantify cyanide based on the high binding affinity of the vitamin B12 analog, cobinamide, for cyanide and a major spectral change observed for cyanide-bound cobinamide. This method is now validated in human blood, and the findings include a mean inter-assay accuracy of 99.1%, precision of 8.75% and a lower limit of quantification of 3.27 µM cyanide. The method was applied to blood samples from children treated with sodium nitroprusside and it yielded measurable results in 88 of 172 samples (51%), whereas the reference laboratory yielded results in only 19 samples (11%). In all 19 samples, the cobinamide-based method also yielded measurable results. The two methods showed reasonable agreement when analyzed by linear regression, but not when analyzed by a standard error of the estimate or paired t-test. Differences in results between the two methods may be because samples were assayed at different times on different sample types. The cobinamide-based method is applicable to human blood, and can be used in hospital laboratories and emergency rooms. PMID:23653045

  13. Comparison of a new cobinamide-based method to a standard laboratory method for measuring cyanide in human blood.

    PubMed

    Swezey, Robert; Shinn, Walter; Green, Carol; Drover, David R; Hammer, Gregory B; Schulman, Scott R; Zajicek, Anne; Jett, David A; Boss, Gerry R

    2013-01-01

    Most hospital laboratories do not measure blood cyanide concentrations, and samples must be sent to reference laboratories. A simple method is needed for measuring cyanide in hospitals. The authors previously developed a method to quantify cyanide based on the high binding affinity of the vitamin B12 analog, cobinamide, for cyanide and a major spectral change observed for cyanide-bound cobinamide. This method is now validated in human blood, and the findings include a mean inter-assay accuracy of 99.1%, precision of 8.75% and a lower limit of quantification of 3.27 µM cyanide. The method was applied to blood samples from children treated with sodium nitroprusside and it yielded measurable results in 88 of 172 samples (51%), whereas the reference laboratory yielded results in only 19 samples (11%). In all 19 samples, the cobinamide-based method also yielded measurable results. The two methods showed reasonable agreement when analyzed by linear regression, but not when analyzed by a standard error of the estimate or paired t-test. Differences in results between the two methods may be because samples were assayed at different times on different sample types. The cobinamide-based method is applicable to human blood, and can be used in hospital laboratories and emergency rooms.

  14. Overview of groundwater and surface water standards pertinent to the Idaho National Engineering Laboratory. Revision 3

    SciTech Connect

    Lundahl, A.L.; Williams, S.; Grizzle, B.J.

    1995-09-01

    This document presents an overview of groundwater- and surface water-related laws, regulations, agreements, guidance documents, Executive Orders, and DOE orders pertinent to the Idaho National Engineering Laboratory. This document is a summary and is intended to help readers understand which regulatory requirements may apply to their particular circumstances. However, the document is not intended to be used in lieu of applicable regulations. Unless otherwise noted, the information in this report reflects a summary and evaluation completed July 1, 1995. This document is considered a Living Document, and updates on changing laws and regulations will be provided.

  15. Inter-laboratory trial of a standardized sediment contact test with the aquatic plant Myriophyllum aquaticum (ISO 16191).

    PubMed

    Feiler, Ute; Ratte, Monika; Arts, Gertie; Bazin, Christine; Brauer, Frank; Casado, Carmen; Dören, Laszlo; Eklund, Britta; Gilberg, Daniel; Grote, Matthias; Gonsior, Guido; Hafner, Christoph; Kopf, Willi; Lemnitzer, Bernd; Liedtke, Anja; Matthias, Uwe; Okos, Ewa; Pandard, Pascal; Scheerbaum, Dirk; Schmitt-Jansen, Mechthild; Stewart, Kathleen; Teodorovic, Ivana; Wenzel, Andrea; Pluta, Hans-Jürgen

    2014-03-01

    A whole-sediment toxicity test with Myriophyllum aquaticum has been developed by the German Federal Institute of Hydrology and standardized within the International Organization for Standardization (ISO; ISO 16191). An international ring-test was performed to evaluate the precision of the test method. Four sediments (artificial, natural) were tested. Test duration was 10 d, and test endpoint was inhibition of growth rate (r) based on fresh weight data. Eighteen of 21 laboratories met the validity criterion of r ≥ 0.09 d(-1) in the control. Results from 4 tests that did not conform to test-performance criteria were excluded from statistical evaluation. The inter-laboratory variability of growth rates (20.6%-25.0%) and inhibition (26.6%-39.9%) was comparable with the variability of other standardized bioassays. The mean test-internal variability of the controls was low (7% [control], 9.7% [solvent control]), yielding a high discriminatory power of the given test design (median minimum detectable differences [MDD] 13% to 15%). To ensure these MDDs, an additional validity criterion of CV ≤ 15% of the growth rate in the controls was recommended. As a positive control, 90 mg 3,5-dichlorophenol/kg sediment dry mass was tested. The range of the expected growth inhibition was proposed to be 35 ± 15%. The ring test results demonstrated the reliability of the ISO 16191 toxicity test and its suitability as a tool to assess the toxicity of sediment and dredged material. © 2013 SETAC.

  16. Isolation gowns in health care settings: Laboratory studies, regulations and standards, and potential barriers of gown selection and use

    PubMed Central

    Kilinc Balci, F. Selcen

    2016-01-01

    Although they play an important role in infection prevention and control, textile materials and personal protective equipment (PPE) used in health care settings are known to be one of the sources of cross-infection. Gowns are recommended to prevent transmission of infectious diseases in certain settings; however, laboratory and field studies have produced mixed results of their efficacy. PPE used in health care is regulated as either class I (low risk) or class II (intermediate risk) devices in the United States. Many organizations have published guidelines for the use of PPE, including isolation gowns, in health care settings. In addition, the Association for the Advancement of Medical Instrumentation published a guidance document on the selection of gowns and a classification standard on liquid barrier performance for both surgical and isolation gowns. However, there is currently no existing standard specific to isolation gowns that considers not only the barrier resistance but also a wide array of end user desired attributes. As a result, infection preventionists and purchasing agents face several difficulties in the selection process, and end users have limited or no information on the levels of protection provided by isolation gowns. Lack of knowledge about the performance of protective clothing used in health care became more apparent during the 2014 Ebola epidemic. This article reviews laboratory studies, regulations, guidelines and standards pertaining to isolation gowns, characterization problems, and other potential barriers of isolation gown selection and use. PMID:26391468

  17. Isolation gowns in health care settings: Laboratory studies, regulations and standards, and potential barriers of gown selection and use.

    PubMed

    Kilinc Balci, F Selcen

    2016-01-01

    Although they play an important role in infection prevention and control, textile materials and personal protective equipment (PPE) used in health care settings are known to be one of the sources of cross-infection. Gowns are recommended to prevent transmission of infectious diseases in certain settings; however, laboratory and field studies have produced mixed results of their efficacy. PPE used in health care is regulated as either class I (low risk) or class II (intermediate risk) devices in the United States. Many organizations have published guidelines for the use of PPE, including isolation gowns, in health care settings. In addition, the Association for the Advancement of Medical Instrumentation published a guidance document on the selection of gowns and a classification standard on liquid barrier performance for both surgical and isolation gowns. However, there is currently no existing standard specific to isolation gowns that considers not only the barrier resistance but also a wide array of end user desired attributes. As a result, infection preventionists and purchasing agents face several difficulties in the selection process, and end users have limited or no information on the levels of protection provided by isolation gowns. Lack of knowledge about the performance of protective clothing used in health care became more apparent during the 2014 Ebola epidemic. This article reviews laboratory studies, regulations, guidelines and standards pertaining to isolation gowns, characterization problems, and other potential barriers of isolation gown selection and use. Published by Elsevier Inc.

  18. Rapid identification of bacteria and yeast: summary of a National Committee for Clinical Laboratory Standards proposed guideline.

    PubMed

    Baron, E J

    2001-07-15

    Using colony morphology on selected agars, Gram-stain morphology, and a number of 1-step biochemical or enzymatic tests, skilled microbiologists can identify the species of the majority of isolates seen routinely in a clinical laboratory. These results are often available more quickly than and are as accurate as those derived from conventional methods. The National Committee for Clinical Laboratory Standards has produced a guideline that describes tests that can be used to identify a number of aerobic gram-negative rods and gram-positive cocci, a number of commonly isolated anaerobes, and 3 species of yeast. An overview of the organisms included in the guideline, the tests that identify them, and the situations in which rapid testing is appropriate is presented here.

  19. Acoustic emissions verification testing of International Space Station experiment racks at the NASA Glenn Research Center Acoustical Testing Laboratory

    NASA Astrophysics Data System (ADS)

    Akers, James C.; Passe, Paul J.; Cooper, Beth A.

    2005-09-01

    The Acoustical Testing Laboratory (ATL) at the NASA John H. Glenn Research Center (GRC) in Cleveland, OH, provides acoustic emission testing and noise control engineering services for a variety of specialized customers, particularly developers of equipment and science experiments manifested for NASA's manned space missions. The ATL's primary customer has been the Fluids and Combustion Facility (FCF), a multirack microgravity research facility being developed at GRC for the USA Laboratory Module of the International Space Station (ISS). Since opening in September 2000, ATL has conducted acoustic emission testing of components, subassemblies, and partially populated FCF engineering model racks. The culmination of this effort has been the acoustic emission verification tests on the FCF Combustion Integrated Rack (CIR) and Fluids Integrated Rack (FIR), employing a procedure that incorporates ISO 11201 (``Acoustics-Noise emitted by machinery and equipment-Measurement of emission sound pressure levels at a work station and at other specified positions-Engineering method in an essentially free field over a reflecting plane''). This paper will provide an overview of the test methodology, software, and hardware developed to perform the acoustic emission verification tests on the CIR and FIR flight racks and lessons learned from these tests.

  20. Improving Data Collection and Analysis Interface for the Data Acquisition Software of the Spin Laboratory at NASA Glenn Research Center

    NASA Technical Reports Server (NTRS)

    Abdul-Aziz, Ali; Curatolo, Ben S.; Woike, Mark R.

    2011-01-01

    In jet engines, turbines spin at high rotational speeds. The forces generated from these high speeds make the rotating components of the turbines susceptible to developing cracks that can lead to major engine failures. The current inspection technologies only allow periodic examinations to check for cracks and other anomalies due to the requirements involved, which often necessitate entire engine disassembly. Also, many of these technologies cannot detect cracks that are below the surface or closed when the crack is at rest. Therefore, to overcome these limitations, efforts at NASA Glenn Research Center are underway to develop techniques and algorithms to detect cracks in rotating engine components. As a part of these activities, a high-precision spin laboratory is being utilized to expand and conduct highly specialized tests to develop methodologies that can assist in detecting predetermined cracks in a rotating turbine engine rotor. This paper discusses the various features involved in the ongoing testing at the spin laboratory and elaborates on its functionality and on the supporting data system tools needed to enable successfully running optimal tests and collecting accurate results. The data acquisition system and the associated software were updated and customized to adapt to the changes implemented on the test rig system and to accommodate the data produced by various sensor technologies. Discussion and presentation of these updates and the new attributes implemented are herein reported