Fv-clasp: An Artificially Designed Small Antibody Fragment with Improved Production Compatibility, Stability, and Crystallizability.

PubMed

Arimori, Takao; Kitago, Yu; Umitsu, Masataka; Fujii, Yuki; Asaki, Ryoko; Tamura-Kawakami, Keiko; Takagi, Junichi

2017-10-03

Antibody fragments are frequently used as a "crystallization chaperone" to aid structural analysis of complex macromolecules that are otherwise crystallization resistant, but conventional fragment formats have not been designed for this particular application. By fusing an anti-parallel coiled-coil structure derived from the SARAH domain of human Mst1 kinase to the variable region of an antibody, we succeeded in creating a novel chimeric antibody fragment of ∼37 kDa, termed "Fv-clasp," which exhibits excellent crystallization compatibility while maintaining the binding ability of the original IgG molecule. The "clasp" and the engineered disulfide bond at the bottom of the Fv suppressed the internal mobility of the fragment and shielded hydrophobic residues, likely contributing to the high heat stability and the crystallizability of the Fv-clasp. Finally, Fv-clasp antibodies showed superior "chaperoning" activity over conventional Fab fragments, and facilitated the structure determination of an ectodomain fragment of integrin α6β1. Copyright © 2017 Elsevier Ltd. All rights reserved.

In-Flight Performance of the Polarization Modulator in the CLASP Rocket Experiment

NASA Technical Reports Server (NTRS)

Ishikawa, Shin-nosuke; Shimizu, Toshifumi; Kano, Ryohei; Bando, Takamasa; Ishikawa, Ryoko; Giono, Gabriel; Beabout, Dyana L.; Beabout, Brent L.; Nakayama, Satoshi; Tajima, Takao

2016-01-01

We developed a polarization modulation unit (PMU), a motor system to rotate a waveplate continuously. In polarization measurements, the continuous rotating waveplate is an important element as well as a polarization analyzer to record the incident polarization in a time series of camera exposures. The control logic of PMU was originally developed for the next Japanese solar observation satellite SOLAR-C by the SOLAR-C working group. We applied this PMU for the Chromospheric Lyman-alpha SpectroPolarimeter (CLASP). CLASP is a sounding rocket experiment to observe the linear polarization of the Lyman-alpha emission (121.6 nm vacuum ultraviolet) from the upper chromosphere and transition region of the Sun with a high polarization sensitivity of 0.1 % for the first time and investigate their vector magnetic field by the Hanle effect. The driver circuit was developed to optimize the rotation for the CLASP waveplate (12.5 rotations per minute). Rotation non-uniformity of the waveplate causes error in the polarization degree (i.e. scale error) and crosstalk between Stokes components. We confirmed that PMU has superior rotation uniformity in the ground test and the scale error and crosstalk of Stokes Q and U are less than 0.01 %. After PMU was attached to the CLASP instrument, we performed vibration tests and confirmed all PMU functions performance including rotation uniformity did not change. CLASP was successfully launched on September 3, 2015, and PMU functioned well as designed. PMU achieved a good rotation uniformity, and the high precision polarization measurement of CLASP was successfully achieved.

Performance characterization of UV science cameras developed for the Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP)

NASA Astrophysics Data System (ADS)

Champey, P.; Kobayashi, K.; Winebarger, A.; Cirtain, J.; Hyde, D.; Robertson, B.; Beabout, D.; Beabout, B.; Stewart, M.

2014-07-01

The NASA Marshall Space Flight Center (MSFC) has developed a science camera suitable for sub-orbital missions for observations in the UV, EUV and soft X-ray. Six cameras will be built and tested for flight with the Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP), a joint National Astronomical Observatory of Japan (NAOJ) and MSFC sounding rocket mission. The goal of the CLASP mission is to observe the scattering polarization in Lyman-α and to detect the Hanle effect in the line core. Due to the nature of Lyman-α polarizationin the chromosphere, strict measurement sensitivity requirements are imposed on the CLASP polarimeter and spectrograph systems; science requirements for polarization measurements of Q/I and U/I are 0.1% in the line core. CLASP is a dual-beam spectro-polarimeter, which uses a continuously rotating waveplate as a polarization modulator, while the waveplate motor driver outputs trigger pulses to synchronize the exposures. The CCDs are operated in frame-transfer mode; the trigger pulse initiates the frame transfer, effectively ending the ongoing exposure and starting the next. The strict requirement of 0.1% polarization accuracy is met by using frame-transfer cameras to maximize the duty cycle in order to minimize photon noise. The CLASP cameras were designed to operate with ≤ 10 e-/pixel/second dark current, ≤ 25 e- read noise, a gain of 2.0 +- 0.5 and ≤ 1.0% residual non-linearity. We present the results of the performance characterization study performed on the CLASP prototype camera; dark current, read noise, camera gain and residual non-linearity.

Internal porosity of cast titanium removable partial dentures: influence of sprue direction and diameter on porosity in simplified circumferential clasps.

PubMed

Baltag, Ioana; Watanabe, Kouichi; Miyakawa, Osamu

2005-06-01

The behavior of molten titanium in molds of complicated shape is still insufficiently understood; consequently, definite spruing criteria are not yet available for titanium RPD frameworks. This study investigated the influence of sprue design on porosity in pressure-cast titanium circumferential clasps. The patterns of 90 circumferential clasps were sprued with three directions (0, 30 and 60 degrees , as measured between the sprue and the symmetry plane of the clasp assembly) and three sprue diameters (1.5, 2.0 and 2.5mm). CPTi was cast in a one-chamber pressure casting machine. Pore number and size were assessed on radiographs of the castings. Statistical analysis was done by two-way analysis of variance (ANOVA), followed by Fisher's PLSD post hoc test. The porosity in lingual arms increased significantly with increase of sprue diameter and sprue angle, while the porosity in minor connectors had an inversely proportional distribution. Very low porosity, uninfluenced by sprue design, was found in buccal arms. In conclusion, internal porosity in titanium circumferential clasp arms can be minimized through sprue design: the 0 degrees sprue direction produced the least porosity, while for the 30 and 60 degrees directions, 1.5mm diameter sprues produced lower porosity than 2.0 and 2.5mm diameter sprues. In this study, the lowest porosity in titanium circumferential clasp arms was obtained with sprues attached perpendicularly to the minor connectors, regardless of sprue diameter. Conventional sprue directions produced significantly higher porosity in clasp lingual arms, the amount of porosity increasing with sprue diameter.

In-flight performance of the polarization modulator in the CLASP rocket experiment

NASA Astrophysics Data System (ADS)

Ishikawa, Shin-nosuke; Shimizu, Toshifumi; Kano, Ryohei; Bando, Takamasa; Ishikawa, Ryoko; Giono, Gabriel; Beabout, Dyana L.; Beabout, Brent L.; Nakayama, Satoshi; Tajima, Takao

2016-07-01

We developed a polarization modulation unit (PMU), a motor system to rotate a waveplate continuously. In polarization measurements, the continuous rotating waveplate is an important element as well as a polarization analyzer to record the incident polarization in a time series of camera exposures. The control logic of PMU was originally developed for the next Japanese solar observation satellite SOLAR-C by the SOLAR-C working group. We applied this PMU for the Chromospheric Lyman-alpha SpectroPolarimeter (CLASP). CLASP is a sounding rocket experiment to observe the linear polarization of the Lyman-alpha emission (121.6 nm vacuum ultraviolet) from the upper chromosphere and transition region of the Sun with a high polarization sensitivity of 0.1 % for the first time and investigate their vector magnetic field by the Hanle effect. The driver circuit was developed to optimize the rotation for the CLASP waveplate (12.5 rotations per minute). Rotation non- uniformity of the waveplate causes error in the polarization degree (i.e. scale error) and crosstalk between Stokes components. We confirmed that PMU has superior rotation uniformity in the ground test and the scale error and crosstalk of Stokes Q and U are less than 0.01 %. After PMU was attached to the CLASP instrument, we performed vibration tests and confirmed all PMU functions performance including rotation uniformity did not change. CLASP was successfully launched on September 3, 2015, and PMU functioned well as designed. PMU achieved a good rotation uniformity, and the high precision polarization measurement of CLASP was successfully achieved.

CLASP2: The Chromospheric LAyer Spectro-Polarimeter

NASA Astrophysics Data System (ADS)

Rachmeler, Laurel; E McKenzie, David; Ishikawa, Ryohko; Trujillo Bueno, Javier; Auchère, Frédéric; Kobayashi, Ken; Winebarger, Amy; Bethge, Christian; Kano, Ryouhei; Kubo, Masahito; Song, Donguk; Narukage, Noriyuki; Ishikawa, Shin-nosuke; De Pontieu, Bart; Carlsson, Mats; Yoshida, Masaki; Belluzzi, Luca; Stepan, Jiri; del Pino Alemná, Tanausú; Ballester, Ernest Alsina; Asensio Ramos, Andres

2017-08-01

We present the instrument, science case, and timeline of the CLASP2 sounding rocket mission. The successful CLASP (Chromospheric Lyman-Alpha Spectro-Polarimeter) sounding rocket flight in 2015 resulted in the first-ever linear polarization measurements of solar hydrogen Lyman-alpha line, which is sensitive to the Hanle effect and can be used to constrain the magnetic field and geometric complexity of the upper chromosphere. Ly-alpha is one of several upper chromospheric lines that contain magnetic information. In the spring of 2019, we will re-fly the modified CLASP telescope to measure the full Stokes profile of Mg II h & k near 280 nm. This set of lines is sensitive to the upper chromospheric magnetic field via both the Hanle and the Zeeman effects.

Performance Characterization of UV Science Cameras Developed for the Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP)

NASA Technical Reports Server (NTRS)

Champey, Patrick; Kobayashi, Ken; Winebarger, Amy; Cirtin, Jonathan; Hyde, David; Robertson, Bryan; Beabout, Brent; Beabout, Dyana; Stewart, Mike

2014-01-01

The NASA Marshall Space Flight Center (MSFC) has developed a science camera suitable for sub-orbital missions for observations in the UV, EUV and soft X-ray. Six cameras will be built and tested for flight with the Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP), a joint National Astronomical Observatory of Japan (NAOJ) and MSFC sounding rocket mission. The goal of the CLASP mission is to observe the scattering polarization in Lyman-alpha and to detect the Hanle effect in the line core. Due to the nature of Lyman-alpha polarization in the chromosphere, strict measurement sensitivity requirements are imposed on the CLASP polarimeter and spectrograph systems; science requirements for polarization measurements of Q/I and U/I are 0.1% in the line core. CLASP is a dual-beam spectro-polarimeter, which uses a continuously rotating waveplate as a polarization modulator, while the waveplate motor driver outputs trigger pulses to synchronize the exposures. The CCDs are operated in frame-transfer mode; the trigger pulse initiates the frame transfer, effectively ending the ongoing exposure and starting the next. The strict requirement of 0.1% polarization accuracy is met by using frame-transfer cameras to maximize the duty cycle in order to minimize photon noise. Coating the e2v CCD57-10 512x512 detectors with Lumogen-E coating allows for a relatively high (30%) quantum efficiency at the Lyman-$\\alpha$ line. The CLASP cameras were designed to operate with =10 e- /pixel/second dark current, = 25 e- read noise, a gain of 2.0 and =0.1% residual non-linearity. We present the results of the performance characterization study performed on the CLASP prototype camera; dark current, read noise, camera gain and residual non-linearity.

A Sounding Rocket Experiment for the Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP)

NASA Technical Reports Server (NTRS)

Kubo, M.; Kano, R.; Kobayashi, K.; Ishikawa, R.; Bando, T.; Narukage, N.; Katsukawa, Y.; Ishikawa, S.; Suematsu, Y.; Hara, H.;

Planning Coverage Campaigns for Mission Design and Analysis: CLASP for DESDynl

NASA Technical Reports Server (NTRS)

Knight, Russell L.; McLaren, David A.; Hu, Steven

2013-01-01

Mission design and analysis presents challenges in that almost all variables are in constant flux, yet the goal is to achieve an acceptable level of performance against a concept of operations, which might also be in flux. To increase responsiveness, automated planning tools are used that allow for the continual modification of spacecraft, ground system, staffing, and concept of operations, while returning metrics that are important to mission evaluation, such as area covered, peak memory usage, and peak data throughput. This approach was applied to the DESDynl mission design using the CLASP planning system, but since this adaptation, many techniques have changed under the hood for CLASP, and the DESDynl mission concept has undergone drastic changes. The software produces mission evaluation products, such as memory highwater marks, coverage percentages, given a mission design in the form of coverage targets, concept of operations, spacecraft parameters, and orbital parameters. It tries to overcome the lack of fidelity and timeliness of mission requirements coverage analysis during mission design. Previous techniques primarily use Excel in ad hoc fashion to approximate key factors in mission performance, often falling victim to overgeneralizations necessary in such an adaptation. The new program allows designers to faithfully represent their mission designs quickly, and get more accurate results just as quickly.

Analysis of Minimum Efficiency Performance Standards for Residential General Service Lighting in Chile

DOE Office of Scientific and Technical Information (OSTI.GOV)

Letschert, Virginie E.; McNeil, Michael A.; Leiva Ibanez, Francisco Humberto

2011-06-01

Minimum Efficiency Performance Standards (MEPS) have been chosen as part of Chile's national energy efficiency action plan. As a first MEPS, the Ministry of Energy has decided to focus on a regulation for lighting that would ban the sale of inefficient bulbs, effectively phasing out the use of incandescent lamps. Following major economies such as the US (EISA, 2007) , the EU (Ecodesign, 2009) and Australia (AS/NZS, 2008) who planned a phase out based on minimum efficacy requirements, the Ministry of Energy has undertaken the impact analysis of a MEPS on the residential lighting sector. Fundacion Chile (FC) and Lawrencemore » Berkeley National Laboratory (LBNL) collaborated with the Ministry of Energy and the National Energy Efficiency Program (Programa Pais de Eficiencia Energetica, or PPEE) in order to produce a techno-economic analysis of this future policy measure. LBNL has developed for CLASP (CLASP, 2007) a spreadsheet tool called the Policy Analysis Modeling System (PAMS) that allows for evaluation of costs and benefits at the consumer level but also a wide range of impacts at the national level, such as energy savings, net present value of savings, greenhouse gas (CO2) emission reductions and avoided capacity generation due to a specific policy. Because historically Chile has followed European schemes in energy efficiency programs (test procedures, labelling program definitions), we take the Ecodesign commission regulation No 244/2009 as a starting point when defining our phase out program, which means a tiered phase out based on minimum efficacy per lumen category. The following data were collected in order to perform the techno-economic analysis: (1) Retail prices, efficiency and wattage category in the current market, (2) Usage data (hours of lamp use per day), and (3) Stock data, penetration of efficient lamps in the market. Using these data, PAMS calculates the costs and benefits of efficiency standards from two distinct but related perspectives: (1) The Life-Cycle Cost (LCC) calculation examines costs and benefits from the perspective of the individual household; and (2) The National Perspective projects the total national costs and benefits including both financial benefits, and energy savings and environmental benefits. The national perspective calculations are called the National Energy Savings (NES) and the Net Present Value (NPV) calculations. PAMS also calculate total emission mitigation and avoided generation capacity. This paper describes the data and methodology used in PAMS and presents the results of the proposed phase out of incandescent bulbs in Chile.« less

34. Detail of neck and shoulder connection showing toga clasp ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

34. Detail of neck and shoulder connection showing toga clasp and shoulder lights that improved nighttime illumination of head. May 1984. - Statue of Liberty, Liberty Island, Manhattan, New York County, NY

The Microtubule-Stabilizing Protein CLASP1 Associates with the Theileria annulata Schizont Surface via Its Kinetochore-Binding Domain

PubMed Central

Huber, Sandra; Theiler, Romina; de Quervain, Daniel; Wiens, Olga; Karangenc, Tulin; Heussler, Volker; Dobbelaere, Dirk

2017-01-01

ABSTRACT Theileria is an apicomplexan parasite whose presence within the cytoplasm of a leukocyte induces cellular transformation and causes uncontrolled proliferation and clonal expansion of the infected cell. The intracellular schizont utilizes the host cell’s own mitotic machinery to ensure its distribution to both daughter cells by associating closely with microtubules (MTs) and incorporating itself within the central spindle. We show that CLASP1, an MT-stabilizing protein that plays important roles in regulating kinetochore-MT attachment and central spindle positioning, is sequestered at the Theileria annulata schizont surface. We used live-cell imaging and immunofluorescence in combination with MT depolymerization assays to demonstrate that CLASP1 binds to the schizont surface in an MT-independent manner throughout the cell cycle and that the recruitment of the related CLASP2 protein to the schizont is MT dependent. By transfecting Theileria-infected cells with a panel of truncation mutants, we found that the kinetochore-binding domain of CLASP1 is necessary and sufficient for parasite localization, revealing that CLASP1 interaction with the parasite occurs independently of EB1. We overexpressed the MT-binding domain of CLASP1 in parasitized cells. This exhibited a dominant negative effect on host MT stability and led to altered parasite size and morphology, emphasizing the importance of proper MT dynamics for Theileria partitioning during host cell division. Using coimmunoprecipitation, we demonstrate that CLASP1 interacts, directly or indirectly, with the schizont membrane protein p104, and we describe for the first time TA03615, a Theileria protein which localizes to the parasite surface, where it has the potential to participate in parasite-host interactions. IMPORTANCE T. annulata, the only eukaryote known to be capable of transforming another eukaryote, is a widespread parasite of veterinary importance that puts 250 million cattle at risk worldwide and limits livestock development for some of the poorest people in the world. Crucial to the pathology of Theileria is its ability to interact with host microtubules and the mitotic spindle of the infected cell. This study builds on our previous work in investigating the host and parasite molecules involved in mediating this interaction. Because it is not possible to genetically manipulate Theileria schizonts, identifying protein interaction partners is critical to understanding the function of parasite proteins. By identifying two Theileria surface proteins that are involved in the interaction between CLASP1 and the parasite, we provide important insights into the molecular basis of Theileria persistence within a dividing cell. PMID:28861517

In-Flight Performance of the Polarization Modulator in the CLASP Rocket Experiment

NASA Technical Reports Server (NTRS)

Ishikawa, S.; Shimizu, T.; Kano, R.; Bando, T.; Ishikawa, R.; Giono, G.; Beabout, D.; Beabout, B.; Nakayama, S.; Tajima, T.

2016-01-01

We developed a polarization modulation unit (PMU), a motor system to rotate a waveplate continuously. We applied this PMU for the Chromospheric Lyman-alpha SpectroPolarimeter (CLASP), a sounding rocket experiment to observe the linear polarization of the Lyman-alpha emission (121.6 nm vacuum ultraviolet) from the upper chromosphere and transition region of the Sun with a high polarization sensitivity of 0.1% for the first time and investigate the vector magnetic field. Rotation non-uniformity of the waveplate causes error in the polarization degree (i.e. scale error) and crosstalk between Stokes components. In the ground tests, we confirmed that PMU has superior rotation uniformity. CLASP was successfully launched on September 3, 2015, and PMU functioned well as designed. PMU achieved a good rotation uniformity during the flight and the high precision polarization measurement of CLASP was successfully achieved.

Chromospheric LAyer SpectroPolarimeter (CLASP2)

NASA Technical Reports Server (NTRS)

Narukage, Noriyuki; Cirtain, Jonathan W.; Ishikawa, Ryoko; Trujillo-Bueno, Javier; De Pontieu, Bart; Kubo, Masahito; Ishikawa, Shinnosuke; Kano, Ryohei; Suematsu, Yoshinori; Yoshida, Masaki;

Arabidopsis  SABRE and CLASP interact to stabilize cell division plane orientation and planar polarity.

PubMed

Pietra, Stefano; Gustavsson, Anna; Kiefer, Christian; Kalmbach, Lothar; Hörstedt, Per; Ikeda, Yoshihisa; Stepanova, Anna N; Alonso, Jose M; Grebe, Markus

2013-01-01

The orientation of cell division and the coordination of cell polarity within the plane of the tissue layer (planar polarity) contribute to shape diverse multicellular organisms. The root of Arabidopsis thaliana displays regularly oriented cell divisions, cell elongation and planar polarity providing a plant model system to study these processes. Here we report that the SABRE protein, which shares similarity with proteins of unknown function throughout eukaryotes, has important roles in orienting cell division and planar polarity. SABRE localizes at the plasma membrane, endomembranes, mitotic spindle and cell plate. SABRE stabilizes the orientation of CLASP-labelled preprophase band microtubules predicting the cell division plane, and of cortical microtubules driving cell elongation. During planar polarity establishment, sabre is epistatic to clasp at directing polar membrane domains of Rho-of-plant GTPases. Our findings mechanistically link SABRE to CLASP-dependent microtubule organization, shedding new light on the function of SABRE-related proteins in eukaryotes.

A Sounding Rocket Experiment for the Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP)

NASA Astrophysics Data System (ADS)

Kubo, M.; Kano, R.; Kobayashi, K.; Bando, T.; Narukage, N.; Ishikawa, R.; Tsuneta, S.; Katsukawa, Y.; Ishikawa, S.; Suematsu, Y.; Hara, H.; Shimizu, T.; Sakao, T.; Ichimoto, K.; Goto, M.; Holloway, T.; Winebarger, A.; Cirtain, J.; De Pontieu, B.; Casini, R.; Auchère, F.; Trujillo Bueno, J.; Manso Sainz, R.; Belluzzi, L.; Asensio Ramos, A.; Štěpán, J.; Carlsson, M.

2014-10-01

A sounding-rocket experiment called the Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP) is presently under development to measure the linear polarization profiles in the hydrogen Lyman-alpha (Lyα) line at 121.567 nm. CLASP is a vacuum-UV (VUV) spectropolarimeter to aim for first detection of the linear polarizations caused by scattering processes and the Hanle effect in the Lyα line with high accuracy (0.1%). This is a fist step for exploration of magnetic fields in the upper chromosphere and transition region of the Sun. Accurate measurements of the linear polarization signals caused by scattering processes and the Hanle effect in strong UV lines like Lyα are essential to explore with future solar telescopes the strength and structures of the magnetic field in the upper chromosphere and transition region of the Sun. The CLASP proposal has been accepted by NASA in 2012, and the flight is planned in 2015.

Simulation and Measurement of Stray Light in the CLASP

NASA Technical Reports Server (NTRS)

Narukage, Noriyuki; Kano, Ryohei; Bando, Takamasa; Ishikawa, Ryoko; Kubo, Masahito; Tsuzuki, Toshihiro; Katsukawa, Yukio; Ishikawa, Shin-nosuke; Giono, Gabriel; Suematsu, Yoshinori;

A Survey of Removable Partial Denture (RPD) Retentive Elements in Relation to the Type of Edentulism and Abutment Teeth Found in Commercial Laboratories, Athens, Greece

PubMed Central

Sotiriou, Michael; Zissis, Alcibiades

2014-01-01

Objective The aim of this survey was to record removable partial denture (RPD) retentive elements and abutment teeth in partially edentulous patients, identified in commercial laboratories in Athens, Greece. Material and Methods 628 master casts with the corresponding cast metal frameworks used in the construction of RPDs were evaluated. Casts were photographed to identify the number and position of existing teeth, the partial edentulism class and the retentive elements. Prevalence tables and the x2 test were used for the statistical analysis of the collected data (α=.05). Results There were 276 maxillary (43.9%) and 352 (56.1%) mandibular casts. Maxillary edentulism entailed almost a total absence of right third molars in 96.7% and left third molars 96.0% of casts, with lower rates for the first and second molars. Edentulism in the posterior mandible presented a similar pattern. The most profound findings concerning retentive elements were: 91.9% of the retainers used were clasps and the remaining 8.1% were attachments. Of the clasps used, 48.9% were of the Roach Τ type, a finding more common in Kennedy Class I as compared to other Kennedy Classes (p<0.01). The circumferential clasps accounted for 19.3% of the total clasps used, and it was less frequently presented (8.8%) in Kennedy I Classes (p<0.01). Conclusions Roach clasps were used in the majority of cases whereas RPI clasps and attachments were rarely used. PMID:27688367

Performance Characterization of UV Science Cameras Developed for the Chromospheric Lyman-Alpha Spectro-Polarimeter

NASA Technical Reports Server (NTRS)

Champey, P.; Kobayashi, K.; Winebarger, A.; Cirtain, J.; Hyde, D.; Robertson, B.; Beabout, D.; Beabout, B.; Stewart, M.

2014-01-01

The NASA Marshall Space Flight Center (MSFC) has developed a science camera suitable for sub-orbital missions for observations in the UV, EUV and soft X-ray. Six cameras will be built and tested for flight with the Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP), a joint National Astronomical Observatory of Japan (NAOJ) and MSFC sounding rocket mission. The goal of the CLASP mission is to observe the scattering polarization in Lyman-alpha and to detect the Hanle effect in the line core. Due to the nature of Lyman-alpha polarization in the chromosphere, strict measurement sensitivity requirements are imposed on the CLASP polarimeter and spectrograph systems; science requirements for polarization measurements of Q/I and U/I are 0.1 percent in the line core. CLASP is a dual-beam spectro-polarimeter, which uses a continuously rotating waveplate as a polarization modulator, while the waveplate motor driver outputs trigger pulses to synchronize the exposures. The CCDs are operated in frame-transfer mode; the trigger pulse initiates the frame transfer, effectively ending the ongoing exposure and starting the next. The strict requirement of 0.1 percent polarization accuracy is met by using frame-transfer cameras to maximize the duty cycle in order to minimize photon noise. Coating the e2v CCD57-10 512x512 detectors with Lumogen-E coating allows for a relatively high (30 percent) quantum efficiency at the Lyman-alpha line. The CLASP cameras were designed to operate with 10 e-/pixel/second dark current, 25 e- read noise, a gain of 2.0 +/- 0.5 and 1.0 percent residual non-linearity. We present the results of the performance characterization study performed on the CLASP prototype camera; dark current, read noise, camera gain and residual non-linearity.

Techno-Economic Analysis of Indian Draft Standard Levels for RoomAir Conditioners

DOE Office of Scientific and Technical Information (OSTI.GOV)

McNeil, Michael A.; Iyer, Maithili

The Indian Bureau of Energy Efficiency (BEE) finalized its first set of efficiency standards and labels for room air conditioners in July of 2006. These regulations followed soon after the publication of levels for frost-free refrigerators in the same year. As in the case of refrigerators, the air conditioner program introduces Minimum Efficiency Performance Standards (MEPS) and comparative labels simultaneously, with levels for one to five stars. Also like the refrigerator program, BEE defined several successive program phases of increasing stringency. In support of BEE's refrigerator program, Lawrence Berkeley National Laboratory (LBNL) produced an analysis of national impacts of standardsmore » in collaboration with the Collaborative Labeling and Standards Program (CLASP). That analysis drew on LBNL's experience with standards programs in the United States, as well as many other countries. Subsequently, as part of the process for setting optimal levels for air conditioner regulations, CLASP commissioned LBNL to provide support to BEE in the form of a techno-economic evaluation of air conditioner efficiency technologies. This report describes the methodology and results of this techno-economic evaluation. The analysis consists of three components: (1) Cost effectiveness to consumers of efficiency technologies relative to current baseline. (2) Impacts on the current market from efficiency regulations. (3) National energy and financial impacts. The analysis relied on detailed and up-to-date technical data made available by BEE and industry representatives. Technical parameters were used in conjunction with knowledge about air conditioner use patterns in the residential and commercial sectors, and prevailing marginal electricity prices, in order to give an estimate of per-unit financial impacts. In addition, the overall impact of the program was evaluated by combining unit savings with market forecasts in order to yield national impacts. LBNL presented preliminary results of these analyses in May 2006, at a meeting of BEEs Technical Committee for Air Conditioners. This meeting was attended by a wide array of stakeholder, including industry representatives, engineers and consumer advocates. Comments made by stakeholders at this meeting are incorporated into the final analysis presented in this report. The current analysis begins with the Rating Plan drafted by BEE in 2006, along with an evaluation of the market baseline according to test data submitted by manufacturers. MEPS, label rating levels, and baseline efficiencies are presented in Section 2. First, we compare Indian MEPS with current standards in other countries, and assess their relative stringency. Baseline efficiencies are then used to estimate the fraction of models likely to remain on the market at each phase of the program, and the impact on market-weighted efficiency levels. Section 3 deals with cost-effectiveness of higher efficiency design options. The cost-benefit analysis is grounded in technical parameters provided by industry representatives in India. This data allows for an assessment of financial costs and benefits to consumers as a result of the standards and labeling program. A Life-Cycle Cost (LCC) calculation is used to evaluate the impacts of the program at the unit level, thus providing some insight into the appropriateness of the levels chosen, and additional opportunities for further ratcheting. In addition to LCC, we also calculate payback periods, cost of conserved energy (CCE), and return on investment (ROI). Finally, Section 4 covers national impacts. This is an extension of unit level estimates in the two previous sections. Extrapolation to the national level depends on a forecast of air conditioner purchases (shipments), which we describe here. Following the cost-benefit analysis, we construct several efficiency scenarios including the BEE plan, but also considering further potential for efficiency improvement. These are combined with shipments through a stock accounting model in order to forecast air conditioner energy consumption in each scenario, and associated electricity savings and carbon emission mitigation. Finally, financial costs and savings are scaled to the national level to evaluate net fiscal benefits.« less

CLASP2 interacts with p120-catenin and governs microtubule dynamics at adherens junctions

PubMed Central

Shahbazi, Marta N.; Megias, Diego; Epifano, Carolina; Akhmanova, Anna; Gundersen, Gregg G.; Fuchs, Elaine

2013-01-01

Classical cadherins and their connections with microtubules (MTs) are emerging as important determinants of cell adhesion. However, the functional relevance of such interactions and the molecular players that contribute to tissue architecture are still emerging. In this paper, we report that the MT plus end–binding protein CLASP2 localizes to adherens junctions (AJs) via direct interaction with p120-catenin (p120) in primary basal mouse keratinocytes. Reductions in the levels of p120 or CLASP2 decreased the localization of the other protein to cell–cell contacts and altered AJ dynamics and stability. These features were accompanied by decreased MT density and altered MT dynamics at intercellular junction sites. Interestingly, CLASP2 was enriched at the cortex of basal progenitor keratinocytes, in close localization to p120. Our findings suggest the existence of a new mechanism of MT targeting to AJs with potential functional implications in the maintenance of proper cell–cell adhesion in epidermal stem cells. PMID:24368809

Modeling the Scattering Polarization of the Hydrogen Ly-alpha Line Observed by CLASP in a Filament Channel

NASA Technical Reports Server (NTRS)

Stepan, J.; Trujillo Bueno, J.; Gunar, S.; del Pino Aleman, T.; Heinzel, P.; Kano, R.; Ishikawa, R.; Narukage, M.; Bando, T.; Winebarger, Amy;

Arabidopsis  SABRE and CLASP interact to stabilize cell division plane orientation and planar polarity

PubMed Central

Pietra, Stefano; Gustavsson, Anna; Kiefer, Christian; Kalmbach, Lothar; Hörstedt, Per; Ikeda, Yoshihisa; Stepanova, Anna N.; Alonso, Jose M.; Grebe, Markus

2013-01-01

The orientation of cell division and the coordination of cell polarity within the plane of the tissue layer (planar polarity) contribute to shape diverse multicellular organisms. The root of Arabidopsis thaliana displays regularly oriented cell divisions, cell elongation and planar polarity providing a plant model system to study these processes. Here we report that the SABRE protein, which shares similarity with proteins of unknown function throughout eukaryotes, has important roles in orienting cell division and planar polarity. SABRE localizes at the plasma membrane, endomembranes, mitotic spindle and cell plate. SABRE stabilizes the orientation of CLASP-labelled preprophase band microtubules predicting the cell division plane, and of cortical microtubules driving cell elongation. During planar polarity establishment, sabre is epistatic to clasp at directing polar membrane domains of Rho-of-plant GTPases. Our findings mechanistically link SABRE to CLASP-dependent microtubule organization, shedding new light on the function of SABRE-related proteins in eukaryotes. PMID:24240534

Spectro-polarimetric observation in UV with CLASP to probe the chromosphere and transition region

NASA Astrophysics Data System (ADS)

Kano, Ryouhei; Ishikawa, Ryohko; Winebarger, Amy R.; Auchère, Frédéric; Trujillo Bueno, Javier; Narukage, Noriyuki; Kobayashi, Ken; Bando, Takamasa; Katsukawa, Yukio; Kubo, Masahito; Ishikawa, Shin-Nosuke; Giono, Gabriel; Hara, Hirohisa; Suematsu, Yoshinori; Shimizu, Toshifumi; Sakao, Taro; Tsuneta, Saku; Ichimoto, Kiyoshi; Goto, Motoshi; Cirtain, Jonathan W.; De Pontieu, Bart; Casini, Roberto; Manso Sainz, Rafael; Asensio Ramos, Andres; Stepan, Jiri; Belluzzi, Luca; Carlsson, Mats

2016-05-01

The Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP) is a NASA sounding-rocket experiment that was performed in White Sands in the US on September 3, 2015. During its 5-minute ballistic flight, CLASP successfully made the first spectro-polarimetric observation in the Lyman-alpha line (121.57 nm) originating in the chromosphere and transition region. Since the Lyman-alpha polarization is sensitive to magnetic field of 10-100 G by the Hanle effect, we aim to infer the magnetic field information in such upper solar atmosphere with this experiment.The obtained CLASP data showed that the Lyman-alpha scattering polarization is about a few percent in the wings and the order of 0.1% in the core near the solar limb, as it had been theoretically predicted, and that both polarization signals have a conspicuous spatio-temporal variability. CLASP also observed another upper-chromospheric line, Si III (120.65 nm), whose critical field strength for the Hanle effect is 290 G, and showed a measurable scattering polarization of a few % in this line. The polarization properties of the Si III line could facilitate the interpretation of the scattering polarization observed in the Lyman-alpha line.In this presentation, we would like to show how the upper chromosphere and transition region are seen in the polarization of these UV lines and discuss the possible source of these complicated polarization signals.

Connecting Libraries and Schools with CLASP.

ERIC Educational Resources Information Center

Del Vecchio, Stephen

1993-01-01

Describes the Dewitt Wallace-Reader's Digest Connecting Libraries and Schools Project (CLASP) of the New York Public Library, a cooperative pilot project to encourage reading among children and youth. Sample projects described include summer reading lists, open school night outreach, and outreach to parents. The importance of materials support is…

VUV Testing of Science Cameras at MSFC: QE Measurement of the CLASP Flight Cameras

NASA Technical Reports Server (NTRS)

Champey, Patrick; Kobayashi, Ken; Winebarger, Amy; Cirtain, Jonathan; Hyde, David; Robertson, Bryan; Beabout, Brent; Beabout, Dyana; Stewart, Mike

2015-01-01

The NASA Marshall Space Flight Center (MSFC) has developed a science camera suitable for sub-orbital missions for observations in the UV, EUV and soft X-ray. Six cameras were built and tested for the Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP), a joint National Astronomical Observatory of Japan (NAOJ) and MSFC sounding rocket mission. The CLASP camera design includes a frame-transfer e2v CCD57-10 512x512 detector, dual channel analog readout electronics and an internally mounted cold block. At the flight operating temperature of -20 C, the CLASP cameras achieved the low-noise performance requirements (less than or equal to 25 e- read noise and greater than or equal to 10 e-/sec/pix dark current), in addition to maintaining a stable gain of approximately equal to 2.0 e-/DN. The e2v CCD57-10 detectors were coated with Lumogen-E to improve quantum efficiency (QE) at the Lyman- wavelength. A vacuum ultra-violet (VUV) monochromator and a NIST calibrated photodiode were employed to measure the QE of each camera. Four flight-like cameras were tested in a high-vacuum chamber, which was configured to operate several tests intended to verify the QE, gain, read noise, dark current and residual non-linearity of the CCD. We present and discuss the QE measurements performed on the CLASP cameras. We also discuss the high-vacuum system outfitted for testing of UV and EUV science cameras at MSFC.

VUV testing of science cameras at MSFC: QE measurement of the CLASP flight cameras

NASA Astrophysics Data System (ADS)

Champey, P.; Kobayashi, K.; Winebarger, A.; Cirtain, J.; Hyde, D.; Robertson, B.; Beabout, B.; Beabout, D.; Stewart, M.

2015-08-01

The NASA Marshall Space Flight Center (MSFC) has developed a science camera suitable for sub-orbital missions for observations in the UV, EUV and soft X-ray. Six cameras were built and tested for the Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP), a joint MSFC, National Astronomical Observatory of Japan (NAOJ), Instituto de Astrofisica de Canarias (IAC) and Institut D'Astrophysique Spatiale (IAS) sounding rocket mission. The CLASP camera design includes a frame-transfer e2v CCD57-10 512 × 512 detector, dual channel analog readout and an internally mounted cold block. At the flight CCD temperature of -20C, the CLASP cameras exceeded the low-noise performance requirements (<= 25 e- read noise and <= 10 e- /sec/pixel dark current), in addition to maintaining a stable gain of ≍ 2.0 e-/DN. The e2v CCD57-10 detectors were coated with Lumogen-E to improve quantum efficiency (QE) at the Lyman- wavelength. A vacuum ultra-violet (VUV) monochromator and a NIST calibrated photodiode were employed to measure the QE of each camera. Three flight cameras and one engineering camera were tested in a high-vacuum chamber, which was configured to operate several tests intended to verify the QE, gain, read noise and dark current of the CCD. We present and discuss the QE measurements performed on the CLASP cameras. We also discuss the high-vacuum system outfitted for testing of UV, EUV and X-ray science cameras at MSFC.

Performance Characterization of UV Science Cameras Developed for the Chromospheric Lyman-Alpha Spectro-Polarimeter

NASA Technical Reports Server (NTRS)

Champey, Patrick; Kobayashi, Ken; Winebarger, Amy; Cirtain, Jonathan; Hyde, David; Robertson, Bryan; Beabout, Brent; Beabout, Dyana; Stewart, Mike

2014-01-01

The NASA Marshall Space Flight Center (MSFC) has developed a science camera suitable for sub-orbital missions for observations in the UV, EUV and soft X-ray. Six cameras will be built and tested for flight with the Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP), a joint National Astronomical Observatory of Japan (NAOJ) and MSFC sounding rocket mission. The goal of the CLASP mission is to observe the scattering polarization in Lyman-alpha and to detect the Hanle effect in the line core. Due to the nature of Lyman-alpha polarization in the chromosphere, strict measurement sensitivity requirements are imposed on the CLASP polarimeter and spectrograph systems; science requirements for polarization measurements of Q/I and U/I are 0.1 percent in the line core. CLASP is a dual-beam spectro- polarimeter, which uses a continuously rotating waveplate as a polarization modulator, while the waveplate motor driver outputs trigger pulses to synchronize the exposures. The CCDs are operated in frame-transfer mode; the trigger pulse initiates the frame transfer, effectively ending the ongoing exposure and starting the next. The strict requirement of 0.1 percent polarization accuracy is met by using frame-transfer cameras to maximize the duty cycle in order to minimize photon noise. Coating the e2v CCD57-10 512x512 detectors with Lumogen-E coating allows for a relatively high (30 percent) quantum efficiency at the Lyman-alpha line. The CLASP cameras were designed to operate with a gain of 2.0 +/- 0.5, less than or equal to 25 e- readout noise, less than or equal to 10 e-/second/pixel dark current, and less than 0.1percent residual non-linearity. We present the results of the performance characterization study performed on the CLASP prototype camera; system gain, dark current, read noise, and residual non-linearity.

Experimental Estimation of CLASP Spatial Resolution: Results of the Instrument's Optical Alignment

NASA Technical Reports Server (NTRS)

Giono, Gabrial; Katsukawa, Yukio; Ishikawa, Ryoko; Narukage, Noriyuki; Bando, Takamasa; Kano, Ryohei; Suematsu, Yoshinori; Kobayashi, Ken; Winebarger, Amy; Auchere, Frederic

2015-01-01

The Chromospheric Lyman-Alpha SpectroPolarimeter (CLASP) is a sounding-rocket experiment currently being built at the National Astronomical Observatory of Japan. This instrument aims to probe for the first time the magnetic field strength and orientation in the solar upper-chromosphere and lower-transition region. CLASP will measure the polarization of the Lyman-Alpha line (121.6nm) with an unprecedented accuracy, and derive the magnetic field information through the Hanle effect. Although polarization accuracy and spectral resolution are crucial for the Hanle effect detection, spatial resolution is also important to get reliable context image via the slit-jaw camera. As spatial resolution is directly related with the alignment of optics, it is also a good way of ensuring the alignment of the instrument to meet the scientific requirement. This poster will detail the experiments carried out to align CLASP's optics (telescope and spectrograph), as both part of the instrument were aligned separately. The telescope was aligned in double-pass mode, and a laser interferometer (He-Ne) was used to measure the telescope's wavefront error (WFE). The secondary mirror tilt and position were adjusted to remove comas and defocus aberrations from the WFE. Effect of gravity on the WFE measurement was estimated and the final WFE derived in zero-g condition for CLASP telescope will be presented. In addition, an estimation of the spot shape and size derived from the final WFE will also be shown. The spectrograph was aligned with a custom procedure: because Ly-??light is absorbed by air, the spectrograph's off-axis parabolic mirrors were aligned in Visible Light (VL) using a custom-made VL grating instead of the flight Ly-? grating. Results of the alignment in Visible Light will be shown and the spot shape recorded with CCDs at various position along the slit will be displayed. Results from both alignment experiment will be compared to the design requirement, and will be combined in order to estimate CLASP spatial resolution after its alignment in visible light.

Accuracy of the Microsoft Kinect sensor for measuring movement in people with Parkinson's disease.

PubMed

Galna, Brook; Barry, Gillian; Jackson, Dan; Mhiripiri, Dadirayi; Olivier, Patrick; Rochester, Lynn

2014-04-01

The Microsoft Kinect sensor (Kinect) is potentially a low-cost solution for clinical and home-based assessment of movement symptoms in people with Parkinson's disease (PD). The purpose of this study was to establish the accuracy of the Kinect in measuring clinically relevant movements in people with PD. Nine people with PD and 10 controls performed a series of movements which were measured concurrently with a Vicon three-dimensional motion analysis system (gold-standard) and the Kinect. The movements included quiet standing, multidirectional reaching and stepping and walking on the spot, and the following items from the Unified Parkinson's Disease Rating Scale: hand clasping, finger tapping, foot, leg agility, chair rising and hand pronation. Outcomes included mean timing and range of motion across movement repetitions. The Kinect measured timing of movement repetitions very accurately (low bias, 95% limits of agreement <10% of the group mean, ICCs >0.9 and Pearson's r>0.9). However, the Kinect had varied success measuring spatial characteristics, ranging from excellent for gross movements such as sit-to-stand (ICC=.989) to very poor for fine movement such as hand clasping (ICC=.012). Despite this, results from the Kinect related strongly to those obtained with the Vicon system (Pearson's r>0.8) for most movements. The Kinect can accurately measure timing and gross spatial characteristics of clinically relevant movements but not with the same spatial accuracy for smaller movements, such as hand clasping. Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.

Making Pre-Kindergarten Work for Low-Income Working Families. CLASP Child Care and Early Education Series. Policy Paper No. 1

ERIC Educational Resources Information Center

Schumacher, Rachel; Hamm, Katie; Ewen, Danielle

2007-01-01

A growing number of state leaders believe that it is essential to expand high-quality early learning and development opportunities for all young children before they reach kindergarten. A key component of this strategy is providing access to voluntary, high-quality pre-kindergarten programs, especially for low-income children. Over the last few…

Immigration Policy's Harmful Impacts on Early Care and Education

ERIC Educational Resources Information Center

Matthews, Hannah; Ullrich, Rebecca; Cervantes, Wendy

2018-01-01

The Center for Law and Social Policy (CLASP) conducted the first ever multi-state study of the effects of the current immigration climate on young children under age 8. In 2017, CLASP interviewed early care and education providers, community-based social service providers, and immigrant parents in six states. The findings, detailed in "Our…

Planning Coverage Campaigns for Mission Design and Analysis: Clasp for the Proposed DESDynI Mission

NASA Technical Reports Server (NTRS)

Knight, Russell; McLaren, David; Hu, Steven

2012-01-01

Mission design and analysis present challenges in that almost all variables are in constant flux, yet the goal is to achieve an acceptable level of performance against a concept of operations, which might also be in flux. To increase responsiveness, our approach is to use automated planning tools that allow for the continual modification of spacecraft, ground system, staffing, and concept of operations while returning metrics that are important to mission evaluation, such as area covered, peak memory usage, and peak data throughput. We have applied this approach to DESDynI (Deformation, Ecosystem Structure, and Dynamics of Ice) mission design concept using the CLASP (Compressed Large-scale Activity Scheduler/Planner) planning system [7], but since this adaptation many techniques have changed under the hood for CLASP and the DESDynI mission concept has undergone drastic changes, including that it has been renamed the Earth Radar Mission. Over the past two years, we have run more than fifty simulations with the CLASP-DESDynI adaptation, simulating different mission scenarios with changing parameters including targets, swaths, instrument modes, and data and downlink rates. We describe the evolution of simulations through the DESDynI MCR (Mission Concept Review) and afterwards.

Title I and Early Childhood Programs: A Look at Investments in the NCLB Era. CLASP Child Care and Early Education Series. Policy Paper No. 2

ERIC Educational Resources Information Center

Ewen, Danielle; Matthews, Hannah

2007-01-01

This paper explores the range of ways in which school districts are using Title I funds for early education through kindergarten and examines how the implementation of No Child Left Behind (NCLB) has impacted those investments. It also makes recommendations for local education agencies (LEAs) interested in creating Title I-funded early education…

Lightweight device to stimulate and monitor human vestibulo-ocular reflex

NASA Technical Reports Server (NTRS)

McStravick, M. Catherine (Inventor); Proctor, David R. (Inventor); Wood, Scott J. (Inventor)

1989-01-01

A helmet formed of a rigid shell is disclosed. The shell is lined with several air filled bladders to contact firmly the head of a user. The shell has a rigid chin bar supporting a bite bar connected fixedly to a mouthpiece bearing against the teeth and hard palate to firmly anchor the helmet without movement. The outer shell surface supports various air pumping bulbs and accelerometers. Separate left and right visor pivot on the side guided in a central tongue and groove track to move optical lens mounts into the user's field of vision. The chin bar is connected to the shell by a pair of releasable clasps. A safety lanyard connects to the clasps to quickly pull pins from the clasps to enable quick release in case of motion sickness.

Sixteen years of collaborative learning through active sense-making in physics (CLASP) at UC Davis

NASA Astrophysics Data System (ADS)

Potter, Wendell; Webb, David; Paul, Cassandra; West, Emily; Bowen, Mark; Weiss, Brenda; Coleman, Lawrence; De Leone, Charles

2014-02-01

This paper describes our large reformed introductory physics course at UC Davis, which bioscience students have been taking since 1996. The central feature of this course is a focus on sense-making by the students during the 5 h per week discussion/labs in which the students take part in activities emphasizing peer-peer discussions, argumentation, and presentations of ideas. The course differs in many fundamental ways from traditionally taught introductory physics courses. After discussing the unique features of CLASP and its implementation at UC Davis, various student outcome measures are presented that show increased performance by students who took the CLASP course compared to students who took a traditionally taught introductory physics course. Measures we use include upper-division GPAs, MCAT scores, FCI gains, and MPEX-II scores.

Energy-Efficiency Labels and Standards: A Guidebook forAppliances, Equipment, and Lighting - 2nd Edition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wiel, Stephen; McMahon, James E.

2005-04-28

Energy-performance improvements in consumer products are an essential element in any government's portfolio of energy-efficiency and climate change mitigation programs. Governments need to develop balanced programs, both voluntary and regulatory, that remove cost-ineffective, energy-wasting products from the marketplace and stimulate the development of cost-effective, energy-efficient technology. Energy-efficiency labels and standards for appliances, equipment, and lighting products deserve to be among the first policy tools considered by a country's energy policy makers. The U.S. Agency for International Development (USAID) and several other organizations identified on the cover of this guidebook recognize the need to support policy makers in their efforts tomore » implement energy-efficiency standards and labeling programs and have developed this guidebook, together with the Collaborative Labeling and Appliance Standards Program (CLASP), as a primary reference. This second edition of the guidebook was prepared over the course of the past year, four years after the preparation of the first edition, with a significant contribution from the authors and reviewers mentioned previously. Their diligent participation helps maintain this book as the international guidance tool it has become. The lead authors would like to thank the members of the Communications Office of the Environmental Energy Technologies Division, Lawrence Berkeley National Laboratory for their support in the development, production, and distribution of the guidebook. This guidebook is designed as a manual for government officials and others around the world responsible for developing, implementing, enforcing, monitoring, and maintaining labeling and standards setting programs. It discusses the pros and cons of adopting energy-efficiency labels and standards and describes the data, facilities, and institutional and human resources needed for these programs. It provides guidance on the design, development, implementation, maintenance, and evaluation of the programs and on the design of the labels and standards themselves. In addition, it directs the reader to references and other resources likely to be useful in conducting the activities described and includes a chapter on energy policies and programs that complement appliance efficiency labels and standards. This guidebook attempts to reflect the essential framework of labeling and standards programs. It is the intent of the authors and sponsor to distribute copies of this book worldwide, at no charge, for the general public benefit. The guidebook is also available on the web at www.clasponline.org and may be downloaded to be used intact or piecemeal for whatever beneficial purposes readers may conceive.« less

Energy-efficiency labels and standards: A guidebook for appliances, equipment and lighting

DOE Office of Scientific and Technical Information (OSTI.GOV)

McMahon, James E.; Wiel, Stephen

2001-02-16

Energy-performance improvements in consumer products are an essential element in any government's portfolio of energy-efficiency and climate change mitigation programs. Governments need to develop balanced programs, both voluntary and regulatory, that remove cost-ineffective, energy-wasting products from the marketplace and stimulate the development of cost-effective, energy-efficient technology. Energy-efficiency labels and standards for appliances, equipment, and lighting products deserve to be among the first policy tools considered by a country's energy policy makers. The U.S. Agency for International Development (USAID) and the United Nations Foundation (UNF) recognize the need to support policy makers in their efforts to implement energy-efficiency standards and labelingmore » programs and have developed this guidebook, together with the Collaborative Labeling and Appliance Standards Program (CLASP), as a primary reference. This guidebook was prepared over the course of the past year with significant contribution from the authors and reviewers mentioned previously. Their diligent participation has made this the international guidance tool it was intended to be. The lead authors would also like to thank the following individuals for their support in the development, production, and distribution of the guidebook: Marcy Beck, Elisa Derby, Diana Dhunke, Ted Gartner, and Julie Osborn of Lawrence Berkeley National Laboratory as well as Anthony Ma of Bevilacqua-Knight, Inc. This guidebook is designed as a manual for government officials and others around the world responsible for developing, implementing, enforcing, monitoring, and maintaining labeling and standards-setting programs. It discusses the pros and cons of adopting energy-efficiency labels and standards and describes the data, facilities, and institutional and human resources needed for these programs. It provides guidance on the design, development, implementation, maintenance, and evaluation of the programs and on the design of the labels and standards themselves. In addition, it directs the reader to references and other resources likely to be useful in conducting the activities described and includes a chapter on energy policies and programs that complement appliance efficiency labels and standards. This guidebook attempts to reflect the essential framework of labeling and standards programs. It is the intent of the authors and sponsors to distribute copies of this book worldwide at no charge for the general public benefit. The guidebook is also available on the web at www.CLASPonline.org and can be downloaded to be used intact or piecemeal for whatever beneficial purposes readers may conceive.« less

Recommended Changes to the No Child Left Behind Act to Address Workforce Issues. Submitted to the House Subcommittee on Higher Education, Lifelong Learning, and Competitiveness of the Committee on Education and Labor

ERIC Educational Resources Information Center

Harris, Linda; Tsoi-A-Fatt, Rhonda

2007-01-01

This paper presents Center for Law and Social Policy's (CLASP's) recommendations on how No Child Left Behind (NCLB) could better address the workforce challenges faced by this country. CLASP is a nonprofit organization engaged in research, analysis, technical assistance, and advocacy on a range of issues affecting low-income families. The…

Advanced software techniques for data management systems. Volume 3: Programming language characteristics and comparison reference

NASA Technical Reports Server (NTRS)

James, T. A.; Hall, B. C.; Newbold, P. M.

1972-01-01

A comparative evaluation was made of eight higher order languages of general interest in the aerospace field: PL/1; HAL; JOVIAL/J3; SPL/J6; CLASP; ALGOL 60; FORTRAN 4; and MAC360. A summary of the functional requirements for a language for general use in manned aerodynamic applications is presented. The evaluation supplies background material to be used in assessing the worth of each language for some particular application.

Comparative study of circumferential clasp retention force for titanium and cobalt-chromium removable partial dentures.

PubMed

Rodrigues, Renata Cristina Silveira; Ribeiro, Ricardo Faria; de Mattos, Maria da Gloria Chiarello; Bezzon, Osvaldo Luiz

2002-09-01

The interest in using titanium to fabricate removable partial denture (RPD) frameworks has increased, but there are few studies to support its use. The objective of this study was to compare circumferential RPD clasps made of commercially pure titanium and identical clasps made of 2 different cobalt (Co)-chromium (Cr) alloys by testing insertion/removal and radiographically inspecting the casts for defects. On refractory casts that represent a partially edentulous mandibular right hemi-arch segment, 36 frameworks were cast from commercially pure titanium (n = 12) and 2 Co-Cr alloys (n = 12 each) with identical prefabricated patterns and the manufacturer-designated investment and casting technique. Each group was divided into 2 subgroups, corresponding to .25-mm and .50-mm undercuts, respectively. No polishing procedures were performed to ensure uniformity. Only nodules and burs were carefully removed with tungsten burs under magnification when necessary. The specimens were radiographed and subjected to an insertion/removal test simulating 5 years of framework use. The data were subjected to analysis of variance and the Tukey complementary test (P<.01) to compare the retentive forces of RPDs made with the different materials. The Student t test (P<.01) was used to compare the retentive forces of RPDs fabricated with the same alloy with different undercuts. A total of 20% of the titanium specimens demonstrated porosity, showing casting difficulties, and any defect detected on the clasps determined the sample replacement. For Co-Cr alloys, casting difficulties were not found. The data were subjected to analysis of variance and the Tukey complementary test to compare materials for the same undercut. For the .25-mm undercut, no significant difference was found between Magnum and Rematitan alloys; they were both different from the Remanium alloy (P<.01). For the.50-mm undercut, no significant difference was found between Co-Cr alloys; they were both different from Rematitan alloy (P<.01). The Student t test used to compare the same alloys with different undercuts showed no significant difference between Remanium with .25-mm and .50-mm undercuts. For Magnum and Rematitan alloys, there was a significant difference between different undercuts (P=.01). Within the limitations of this simulation study, the results suggest that commercially pure titanium clasps maintained retention over a simulated 5-year period, with lower retention force than identical Co-Cr clasps.

The Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP)

NASA Technical Reports Server (NTRS)

Ishikawa, Shin-nosuke; Kano, R.; Kobayashi, K.; Bando, T.; Narukage, N..; Ishikawa, R.; Kubo, M.; Katsukawa, Y.; Suematsu, Y.; Hara, H.;

Chromospheric Lyman-alpha spectro-polarimeter (CLASP)

NASA Astrophysics Data System (ADS)

Kano, Ryouhei; Bando, Takamasa; Narukage, Noriyuki; Ishikawa, Ryoko; Tsuneta, Saku; Katsukawa, Yukio; Kubo, Masahito; Ishikawa, Shin-nosuke; Hara, Hirohisa; Shimizu, Toshifumi; Suematsu, Yoshinori; Ichimoto, Kiyoshi; Sakao, Taro; Goto, Motoshi; Kato, Yoshiaki; Imada, Shinsuke; Kobayashi, Ken; Holloway, Todd; Winebarger, Amy; Cirtain, Jonathan; De Pontieu, Bart; Casini, Roberto; Trujillo Bueno, Javier; Štepán, Jiří; Manso Sainz, Rafael; Belluzzi, Luca; Asensio Ramos, Andres; Auchère, Frédéric; Carlsson, Mats

2012-09-01

One of the biggest challenges in heliophysics is to decipher the magnetic structure of the solar chromosphere. The importance of measuring the chromospheric magnetic field is due to both the key role the chromosphere plays in energizing and structuring the outer solar atmosphere and the inability of extrapolation of photospheric fields to adequately describe this key boundary region. Over the last few years, significant progress has been made in the spectral line formation of UV lines as well as the MHD modeling of the solar atmosphere. It is found that the Hanle effect in the Lyman-alpha line (121.567 nm) is a most promising diagnostic tool for weaker magnetic fields in the chromosphere and transition region. Based on this groundbreaking research, we propose the Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP) to NASA as a sounding rocket experiment, for making the first measurement of the linear polarization produced by scattering processes and the Hanle effect in the Lyman-alpha line (121.567 nm), and making the first exploration of the magnetic field in the upper chromosphere and transition region of the Sun. The CLASP instrument consists of a Cassegrain telescope, a rotating 1/2-wave plate, a dual-beam spectrograph assembly with a grating working as a beam splitter, and an identical pair of reflective polarization analyzers each equipped with a CCD camera. We propose to launch CLASP in December 2014.

Linearity Analysis and Efficiency Testing of The Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP) Science Cameras for Flight

NASA Astrophysics Data System (ADS)

Walker, S. C.; Rachmeler, L.; Winebarger, A. R.; Champey, P. R.; Bethge, C.

2017-12-01

To unveil the complexity of the solar atmosphere, measurement of the magnetic field in the upper chromosphere and transition region is fundamentally important, as this is where the forces transition from plasma to magnetic field dominated. Measurements of the field are also needed to shed light on the energy transport from the lower atmospheric regions to the corona beyond. Such an advance in heliospheric knowledge became possible with the first flight of the international solar sounding rocket mission, CLASP. For the first time, linear polarization was measured in H Lyman-Alpha at 121.60 nm in September 2015. For linear polarization measurements in this line, high sensitivity is required due to the relatively weak polarization signal compared to the intensity. To achieve this high sensitivity, a low-noise sensor is required with good knowledge of its characterization, including linearity. This work presents further refinement of the linearity characterization of the cameras flown in 2015. We compared the current from a photodiode in the light path to the digital response of the detectors. Pre-flight CCD linearity measurements were taken for all three flight cameras and calculations of the linear fits and residuals were performed. However, the previous calculations included a smearing pattern and a digital saturation region on the detectors which were not properly taken into account. The calculations have been adjusted and were repeated for manually chosen sub-regions on the detectors that were found not to be affected. We present a brief overview of the instrument, the calibration data and procedures, and a comparison of the old and new linearity results. The CLASP cameras will be reused for the successor mission, CLASP2, which will measure the Mg II h & k lines between 279.45 nm and 280.35 nm. The new approach will help to better prepare for and to improve the camera characterization for CLASP2.

Linearity Analysis and Efficiency Testing of The Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP) Science Cameras for Flight

NASA Technical Reports Server (NTRS)

Walker, Salma C.; Rachmeler, Laurel; Winebarger, Amy; Champey, Patrick; Bethge, Christian

2017-01-01

To unveil the complexity of the solar atmosphere, measurement of the magnetic field in the upper chromosphere and transition region is fundamentally important, as this is where the forces transition from plasma to magnetic field dominated. Measurements of the field are also needed to elucidate the energy transport from the lower atmospheric regions to the corona beyond. Such an advance in heliospheric knowledge became possible with the first flight of the international solar sounding rocket mission, CLASP. For the first time, linear polarization was measured in Hydrogen Lyman-Alpha at 121.60 nm in September 2015. For linear polarization measurements in this emission line, high sensitivity is required due to the relatively weak polarization signal compared to the intensity. To achieve this high sensitivity, a low-noise sensor is required with good knowledge of its characterization, including linearity. This work presents further refinement of the linearity characterization of the cameras flown in 2015. We compared the current from a photodiode in the light path to the digital response of the detectors. Pre-flight CCD linearity measurements were taken for all three flight cameras and calculations of the linear fits and residuals were performed. However, the previous calculations included a smearing pattern and a digital saturation region on the detectors which were not properly taken into account. The calculations have been adjusted and were repeated for manually chosen sub-regions on the detectors that were found not to be affected. We present a brief overview of the instrument, the calibration data and procedures, and a comparison of the old and new linearity results. The CLASP cameras will be reused for the successor mission, CLASP2, which will measure the Magnesium II h & k emission lines between 279.45 nm and 280.35 nm. The new approach will help to better prepare for and to improve the camera characterization for CLASP2.

Linearity Analysis and Efficiency Testing of The Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP) Science Cameras for Flight

NASA Technical Reports Server (NTRS)

Walker, Salma C.; Rachmeler, Laurel; Winebarger, Amy; Champey, Patrick; Bethge, Christian

2018-01-01

To unveil the complexity of the solar atmosphere, measurement of the magnetic field in the upper chromosphere and transition region is fundamentally important, as this is where the forces transition from plasma to magnetic field dominated. Measurements of the field are also needed to elucidate the energy transport from the lower atmospheric regions to the corona beyond. Such an advance in heliospheric knowledge became possible with the first flight of the international solar sounding rocket mission, CLASP. For the first time, linear polarization was measured in Hydrogen Lyman-Alpha at 121.60 nm in September 2015. For linear polarization measurements in this emission line, high sensitivity is required due to the relatively weak polarization signal compared to the intensity. To achieve this high sensitivity, a low-noise sensor is required with good knowledge of its characterization, including linearity. This work presents further refinement of the linearity characterization of the cameras flown in 2015. We compared the current from a photodiode in the light path to the digital response of the detectors. Pre-flight CCD linearity measurements were taken for all three flight cameras and calculations of the linear fits and residuals were performed. However, the previous calculations included a smearing pattern and a digital saturation region on the detectors which were not properly taken into account. The calculations have been adjusted and were repeated for manually chosen sub-regions on the detectors that were found not to be affected. We present a brief overview of the instrument, the calibration data and procedures, and a comparison of the old and new linearity results. The CLASP cameras will be reused for the successor mission, CLASP2, which will measure the Magnesium II h & k emission lines between 279.45 nm and 280.35 nm. The new approach will help to better prepare for and to improve the camera characterization for CLASP2.

Development of a KSC test and flight engineering oriented computer language, Phase 1

NASA Technical Reports Server (NTRS)

Case, C. W.; Kinney, E. L.; Gyure, J.

1970-01-01

Ten, primarily test oriented, computer languages reviewed during the phase 1 study effort are described. Fifty characteristics of ATOLL, ATLAS, and CLASP are compared. Unique characteristics of the other languages, including deficiencies, problems, safeguards, and checking provisions are identified. Programming aids related to these languages are reported, and the conclusions resulting from this phase of the study are discussed. A glossary and bibliography are included. For the reports on phase 2 of the study, see N71-35027 and N71-35029.

MTCL1 crosslinks and stabilizes non-centrosomal microtubules on the Golgi membrane.

PubMed

Sato, Yoshinori; Hayashi, Kenji; Amano, Yoshiko; Takahashi, Mikiko; Yonemura, Shigenobu; Hayashi, Ikuko; Hirose, Hiroko; Ohno, Shigeo; Suzuki, Atsushi

2014-11-04

Recent studies have revealed the presence of a microtubule subpopulation called Golgi-derived microtubules that support Golgi ribbon formation, which is required for maintaining polarized cell migration. CLASPs and AKAP450/CG-NAP are involved in their formation, but the underlying molecular mechanisms remain unclear. Here, we find that the microtubule-crosslinking protein, MTCL1, is recruited to the Golgi membranes through interactions with CLASPs and AKAP450/CG-NAP, and promotes microtubule growth from the Golgi membrane. Correspondingly, MTCL1 knockdown specifically impairs the formation of the stable perinuclear microtubule network to which the Golgi ribbon tethers and extends. Rescue experiments demonstrate that besides its crosslinking activity mediated by the N-terminal microtubule-binding region, the C-terminal microtubule-binding region plays essential roles in these MTCL1 functions through a novel microtubule-stabilizing activity. These results suggest that MTCL1 cooperates with CLASPs and AKAP450/CG-NAP in the formation of the Golgi-derived microtubules, and mediates their development into a stable microtubule network.

Clasp/SJ Observation of Time Variations of Lyman-Alpha Emissions in a Solar Active Region

NASA Technical Reports Server (NTRS)

Ishikawa, S.; Kubo, M.; Katsukawa, Y.; Kano, R.; Narukage, N.; Ishikawa, R.; Bando, T.; Winebarger, A.; Kobayashi, K.; Trujillo Bueno, J.;

CLASP: A UV Spectropolarimeter on a Sounding Rocket for Probing theChromosphere-Corona Transition Regio

NASA Astrophysics Data System (ADS)

Ishikawa, Ryohko; Kano, Ryouhei; Winebarger, Amy; Auchere, Frederic; Trujillo Bueno, Javier; Bando, Takamasa; Narukage, Noriyuki; Kobayashi, Ken; Katsukawa, Yukio; Kubo, Masahito; Ishikawa, Shin-nosuke; Giono, Gabriel; Tsuneta, Saku; Hara, Hirohisa; Suematsu, Yoshinori; Shimizu, Toshifumi; Sakao, Taro; Ichimoto, Kiyoshi; Cirtain, Jonathan; De Pontieu, Bart; Casini, Roberto; Manso Sainz, Rafael; Asensio Ramos, Andres; Stepan, Jiri; Belluzzi, Luca

2015-08-01

The wish to understand the energetic phenomena of the outer solar atmosphere makes it increasingly important to achieve quantitative information on the magnetic field in the chromosphere-corona transition region. To this end, we need to measure and model the linear polarization produced by scattering processes and the Hanle effect in strong UV resonance lines, such as the hydrogen Lyman-alpha line. A team consisting of Japan, USA, Spain, France, and Norway has been developing a sounding rocket experiment called the Chromospheric Lyman-alpha Spectro-Polarimeter (CLASP). The aim is to detect the scattering polarization produced by anisotropic radiation pumping in the hydrogen Lyman-alpha line (121.6 nm), and via the Hanle effect to try to constrain the magnetic field vector in the upper chromosphere and transition region. In this talk, we will present an overview of our CLASP mission, its scientific objectives, ground tests made, and the latest information on the launch planned for the Summer of 2015.

Discovery of Ubiquitous Fast-Propagating Intensity Disturbances by the Chromospheric Lyman Alpha Spectropolarimeter (CLASP)

NASA Astrophysics Data System (ADS)

Kubo, M.; Katsukawa, Y.; Suematsu, Y.; Kano, R.; Bando, T.; Narukage, N.; Ishikawa, R.; Hara, H.; Giono, G.; Tsuneta, S.; Ishikawa, S.; Shimizu, T.; Sakao, T.; Winebarger, A.; Kobayashi, K.; Cirtain, J.; Champey, P.; Auchère, F.; Trujillo Bueno, J.; Asensio Ramos, A.; Štěpán, J.; Belluzzi, L.; Manso Sainz, R.; De Pontieu, B.; Ichimoto, K.; Carlsson, M.; Casini, R.; Goto, M.

2016-12-01

High-cadence observations by the slit-jaw (SJ) optics system of the sounding rocket experiment known as the Chromospheric Lyman Alpha Spectropolarimeter (CLASP) reveal ubiquitous intensity disturbances that recurrently propagate in either the chromosphere or the transition region or both at a speed much higher than the speed of sound. The CLASP/SJ instrument provides a time series of two-dimensional images taken with broadband filters centered on the Lyα line at a 0.6 s cadence. The multiple fast-propagating intensity disturbances appear in the quiet Sun and in an active region, and they are clearly detected in at least 20 areas in a field of view of 527″ × 527″ during the 5 minute observing time. The apparent speeds of the intensity disturbances range from 150 to 350 km s-1, and they are comparable to the local Alfvén speed in the transition region. The intensity disturbances tend to propagate along bright elongated structures away from areas with strong photospheric magnetic fields. This suggests that the observed fast-propagating intensity disturbances are related to the magnetic canopy structures. The maximum distance traveled by the intensity disturbances is about 10″, and the widths are a few arcseconds, which are almost determined by a pixel size of 1.″03. The timescale of each intensity pulse is shorter than 30 s. One possible explanation for the fast-propagating intensity disturbances observed by CLASP is magnetohydrodynamic fast-mode waves.

Discovery of Ubiquitous Fast Propagating Intensity Disturbances by the Chromospheric Lyman Alpha Spectropolarimeter (CLASP)

NASA Technical Reports Server (NTRS)

Kubo, M.; Katsukawa, Y.; Suematsu, Y.; Kano, R.; Bando, T.; Narukage, N.; Ishikawa, R.; Hara, H.; Giono, G.; Tsuneta, S.;

Therapeutic Effects of Anthocyanins and Environmental Enrichment in R6/1 Huntington's Disease Mice.

PubMed

Kreilaus, Fabian; Spiro, Adena S; Hannan, Anthony J; Garner, Brett; Jenner, Andrew M

2016-10-01

Huntington's disease (HD) is a progressive neurodegenerative disease with no effective treatment or cure. Environmental enrichment has been used to slow processes leading to ageing and neurodegenerative diseases including HD. Phenolic phytochemicals including anthocyanins have also been shown to improve brain function in ageing and neurodegenerative diseases. This study examined the effects of anthocyanin dietary supplementation and environmental enrichment on behavioural phenotypes and brain cholesterol metabolic alterations in the R6/1 mouse model of HD. R6/1 HD mice and their wild-type littermate controls were randomised into the different experimental conditions, involving either environmentally enriched versus standard housing conditions, or anthocyanin versus control diet. Motor dysfunction was assessed from 6 to 26 weeks using the RotaRod and the hind-paw clasping tests. Gas chromatography - tandem mass spectrometry was used to quantify a broad range of sterols in the striatum and cortex of R6/1 HD mice. Anthocyanin dietary supplementation delayed the onset of motor dysfunction in female HD mice. Environmental enrichment improved motor function and the hind paw clasping phenotype in male HD mice only. These mice also had lower levels of cholesterol oxidation products in the cortex compared to standard-housed mice. Both anthocyanin supplementation and environmental enrichment are able to improve the motor dysfunction phenotype of R6/1 mice, however the effectiveness of these interventions was different between the two sexes. The interventions examined did not alter brain cholesterol metabolic deficits that have been reported previously in this mouse model of HD.

Vocal communication between male Xenopus laevis.

PubMed

Tobias, Martha L; Barnard, Candace; O'Hagan, Robert; Horng, Sam H; Rand, Masha; Kelley, Darcy B

2004-02-01

This study focuses on the role of male-male vocal communication in the reproductive repertoire of the South African clawed frog, Xenopus laevis . Six male and two female call types were recorded from native ponds in the environs of Cape Town, South Africa. These include all call types previously recorded in the laboratory as well as one previously unidentified male call: chirping. The amount of calling and the number of call types increased as the breeding season progressed. Laboratory recordings indicated that all six male call types were directed to males; three of these were directed to both sexes and three were directed exclusively to males. Both female call types were directed exclusively to males. The predominant call type, in both field and laboratory recordings, was the male advertisement call. Sexual state affected male vocal behaviour. Male pairs in which at least one male was sexually active (gonadotropin injected) produced all call types, whereas pairs of uninjected males rarely called. Some call types were strongly associated with a specific behaviour and others were not. Clasped males always growled and clasping males typically produced amplectant calls or chirps; males not engaged in clasping most frequently advertised. The amount of advertising produced by one male was profoundly affected by the presence of another male. Pairing two sexually active males resulted in suppression of advertisement calling in one; suppression was released when males were isolated after pairing. Vocal dominance was achieved even in the absence of physical contact (clasping). We suggest that X. laevis males gain a reproductive advantage by competing for advertisement privileges and by vocally suppressing neighbouring males.

S. pombe CLASP needs dynein, not EB1 or CLIP170, to induce microtubule instability and slows polymerization rates at cell tips in a dynein-dependent manner

PubMed Central

Grallert, Agnes; Beuter, Christoph; Craven, Rachel A.; Bagley, Steve; Wilks, Deepti; Fleig, Ursula; Hagan, Iain M.

2006-01-01

The Schizosaccharomyces pombe CLIP170-associated protein (CLASP) Peg1 was identified in a screen for mutants with spindle formation defects and a screen for molecules that antagonized EB1 function. The conditional peg1.1 mutant enabled us to identify key features of Peg1 function. First, Peg1 was required to form a spindle and astral microtubules, yet destabilized interphase microtubules. Second, Peg1 was required to slow the polymerization rate of interphase microtubules that establish end-on contact with the cortex at cell tips. Third, Peg1 antagonized the action of S. pombe CLIP170 (Tip1) and EB1 (Mal3). Fourth, although Peg1 resembled higher eukaryotic CLASPs by physically associating with both Mal3 and Tip1, neither Tip1 nor Mal3 was required for Peg1 to destabilize interphase microtubules or for it to associate with microtubules. Conversely, neither Mal3 nor Tip1 required Peg1 to associate with microtubules or cell tips. Consistently, while mal3.Δ and tip1.Δ disrupted linear growth, corrupting peg1 + did not. Fifth, peg1.1 phenotypes resembled those arising from deletion of the single heavy or both light chains of fission yeast dynein. Furthermore, all interphase phenotypes arising from peg1 + manipulation relied on dynein function. Thus, the impact of S. pombe CLASP on interphase microtubule behavior is more closely aligned to dynein than EB1 or CLIP170. PMID:16951255

GSK3 controls axon growth via CLASP-mediated regulation of growth cone microtubules

PubMed Central

Hur, Eun-Mi; Saijilafu; Lee, Byoung Dae; Kim, Seong-Jin; Xu, Wen-Lin; Zhou, Feng-Quan

2011-01-01

Suppression of glycogen synthase kinase 3 (GSK3) activity in neurons yields pleiotropic outcomes, causing both axon growth promotion and inhibition. Previous studies have suggested that specific GSK3 substrates, such as adenomatous polyposis coli (APC) and collapsin response mediator protein 2 (CRMP2), support axon growth by regulating the stability of axonal microtubules (MTs), but the substrate(s) and mechanisms conveying axon growth inhibition remain elusive. Here we show that CLIP (cytoplasmic linker protein)-associated protein (CLASP), originally identified as a MT plus end-binding protein, displays both plus end-binding and lattice-binding activities in nerve growth cones, and reveal that the two MT-binding activities regulate axon growth in an opposing manner: The lattice-binding activity mediates axon growth inhibition induced by suppression of GSK3 activity via preventing MT protrusion into the growth cone periphery, whereas the plus end-binding property supports axon extension via stabilizing the growing ends of axonal MTs. We propose a model in which CLASP transduces GSK3 activity levels to differentially control axon growth by coordinating the stability and configuration of growth cone MTs. PMID:21937714

Crystal structure studies of NADP{sup +} dependent isocitrate dehydrogenase from Thermus thermophilus exhibiting a novel terminal domain

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kumar, S.M.; Pampa, K.J.; Manjula, M.

2014-06-20

Highlights: • We determined the structure of isocitrate dehydrogenase with citrate and cofactor. • The structure reveals a unique novel terminal domain involved in dimerization. • Clasp domain shows significant difference, and catalytic residues are conserved. • Oligomerization of the enzyme is quantized with subunit-subunit interactions. • Novel domain of this enzyme is classified as subfamily of the type IV. - Abstract: NADP{sup +} dependent isocitrate dehydrogenase (IDH) is an enzyme catalyzing oxidative decarboxylation of isocitrate into oxalosuccinate (intermediate) and finally the product α-ketoglutarate. The crystal structure of Thermus thermophilus isocitrate dehydrogenase (TtIDH) ternary complex with citrate and cofactor NADP{supmore » +} was determined using X-ray diffraction method to a resolution of 1.80 Å. The overall fold of this protein was resolved into large domain, small domain and a clasp domain. The monomeric structure reveals a novel terminal domain involved in dimerization, very unique and novel domain when compared to other IDH’s. And, small domain and clasp domain showing significant differences when compared to other IDH’s of the same sub-family. The structure of TtIDH reveals the absence of helix at the clasp domain, which is mainly involved in oligomerization in other IDH’s. Also, helices/beta sheets are absent in the small domain, when compared to other IDH’s of the same sub family. The overall TtIDH structure exhibits closed conformation with catalytic triad residues, Tyr144-Asp248-Lys191 are conserved. Oligomerization of the protein is quantized using interface area and subunit–subunit interactions between protomers. Overall, the TtIDH structure with novel terminal domain may be categorized as a first structure of subfamily of type IV.« less

Discovery of Short-Timescale Oscillations in the Transition Region by CLASP

NASA Technical Reports Server (NTRS)

Kubo, M.; Katsukawa, Y.; Kano, R.; Winebarger, A.; Kobayashi, K.; Ishikawa, R.; Narukage, N.; Bando, T.; Suematsu, Y.; Giono, G.;

Antigen clasping by two antigen-binding sites of an exceptionally specific antibody for histone methylation

DOE PAGES

Hattori, Takamitsu; Lai, Darson; Dementieva, Irina S.; ...

2016-02-09

Antibodies have a well-established modular architecture wherein the antigen-binding site residing in the antigen-binding fragment (Fab or Fv) is an autonomous and complete unit for antigen recognition. Here, we describe antibodies departing from this paradigm. We developed recombinant antibodies to trimethylated lysine residues on histone H3, important epigenetic marks and challenging targets for molecular recognition. Quantitative characterization demonstrated their exquisite specificity and high affinity, and they performed well in common epigenetics applications. Surprisingly, crystal structures and biophysical analyses revealed that two antigen-binding sites of these antibodies form a head-to-head dimer and cooperatively recognize the antigen in the dimer interface. Thismore » “antigen clasping” produced an expansive interface where trimethylated Lys bound to an unusually extensive aromatic cage in one Fab and the histone N terminus to a pocket in the other, thereby rationalizing the high specificity. A long-neck antibody format with a long linker between the antigen-binding module and the Fc region facilitated antigen clasping and achieved both high specificity and high potency. Antigen clasping substantially expands the paradigm of antibody–antigen recognition and suggests a strategy for developing extremely specific antibodies.« less

Antigen clasping by two antigen-binding sites of an exceptionally specific antibody for histone methylation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hattori, Takamitsu; Lai, Darson; Dementieva, Irina S.

Antibodies have a well-established modular architecture wherein the antigen-binding site residing in the antigen-binding fragment (Fab or Fv) is an autonomous and complete unit for antigen recognition. Here, we describe antibodies departing from this paradigm. We developed recombinant antibodies to trimethylated lysine residues on histone H3, important epigenetic marks and challenging targets for molecular recognition. Quantitative characterization demonstrated their exquisite specificity and high affinity, and they performed well in common epigenetics applications. Surprisingly, crystal structures and biophysical analyses revealed that two antigen-binding sites of these antibodies form a head-to-head dimer and cooperatively recognize the antigen in the dimer interface. Thismore » “antigen clasping” produced an expansive interface where trimethylated Lys bound to an unusually extensive aromatic cage in one Fab and the histone N terminus to a pocket in the other, thereby rationalizing the high specificity. A long-neck antibody format with a long linker between the antigen-binding module and the Fc region facilitated antigen clasping and achieved both high specificity and high potency. Antigen clasping substantially expands the paradigm of antibody–antigen recognition and suggests a strategy for developing extremely specific antibodies.« less

Performance Characterization of the Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP) CCD Cameras

NASA Technical Reports Server (NTRS)

Joiner, Reyann; Kobayashi, Ken; Winebarger, Amy; Champey, Patrick

2014-01-01

The Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP) is a sounding rocket instrument which is currently being developed by NASA's Marshall Space Flight Center (MSFC) and the National Astronomical Observatory of Japan (NAOJ). The goal of this instrument is to observe and detect the Hanle effect in the scattered Lyman-Alpha UV (121.6nm) light emitted by the Sun's Chromosphere to make measurements of the magnetic field in this region. In order to make accurate measurements of this effect, the performance characteristics of the three on-board charge-coupled devices (CCDs) must meet certain requirements. These characteristics include: quantum efficiency, gain, dark current, noise, and linearity. Each of these must meet predetermined requirements in order to achieve satisfactory performance for the mission. The cameras must be able to operate with a gain of no greater than 2 e(-)/DN, a noise level less than 25e(-), a dark current level which is less than 10e(-)/pixel/s, and a residual nonlinearity of less than 1%. Determining these characteristics involves performing a series of tests with each of the cameras in a high vacuum environment. Here we present the methods and results of each of these performance tests for the CLASP flight cameras.

Pheromones enhance somatosensory processing in newt brains through a vasotocin-dependent mechanism.

PubMed

Thompson, R R; Dickinson, P S; Rose, J D; Dakin, K A; Civiello, G M; Segerdahl, A; Bartlett, R

2008-07-22

We tested whether the sex pheromones that stimulate courtship clasping in male roughskin newts do so, at least in part, by amplifying the somatosensory signals that directly trigger the motor pattern associated with clasping and, if so, whether that amplification is dependent on endogenous vasotocin (VT). Female olfactory stimuli increased the number of action potentials recorded in the medulla of males in response to tactile stimulation of the cloaca, which triggers the clasp motor reflex, as well as to tactile stimulation of the snout and hindlimb. That enhancement was blocked by exposing the medulla to a V1a receptor antagonist before pheromone exposure. However, the antagonist did not affect medullary responses to tactile stimuli in the absence of pheromone exposure, suggesting that pheromones amplify somatosensory signals by inducing endogenous VT release. The ability of VT to couple sensory systems together in response to social stimulation could allow this peptide to induce variable behavioural outcomes, depending on the immediate context of the social interaction and thus on the nature of the associated stimuli that are amplified. If widespread in vertebrates, this mechanism could account for some of the behavioural variability associated with this and related peptides both within and across species.

Performance Characterization of the Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP) CCD Cameras

NASA Astrophysics Data System (ADS)

Joiner, R. K.; Kobayashi, K.; Winebarger, A. R.; Champey, P. R.

2014-12-01

The Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP) is a sounding rocket instrument which is currently being developed by NASA's Marshall Space Flight Center (MSFC) and the National Astronomical Observatory of Japan (NAOJ). The goal of this instrument is to observe and detect the Hanle effect in the scattered Lyman-Alpha UV (121.6nm) light emitted by the Sun's Chromosphere to make measurements of the magnetic field in this region. In order to make accurate measurements of this effect, the performance characteristics of the three on-board charge-coupled devices (CCDs) must meet certain requirements. These characteristics include: quantum efficiency, gain, dark current, noise, and linearity. Each of these must meet predetermined requirements in order to achieve satisfactory performance for the mission. The cameras must be able to operate with a gain of no greater than 2 e-/DN, a noise level less than 25e-, a dark current level which is less than 10e-/pixel/s, and a residual non-linearity of less than 1%. Determining these characteristics involves performing a series of tests with each of the cameras in a high vacuum environment. Here we present the methods and results of each of these performance tests for the CLASP flight cameras.

Si III OV Bright Line of Scattering Polarized Light That Has Been Observed in the CLASP and Its Center-to-Limb Variation

NASA Technical Reports Server (NTRS)

Katsukawa, Yukio; Ishikawa, Ryoko; Kano, Ryohei; Kubo, Masahito; Noriyuki, Narukage; Kisei, Bando; Hara, Hirohisa; Yoshiho, Suematsu; Goto, Motouji; Ishikawa, Shinnosuke;

Performance Characterization of the Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP) CCD Cameras

NASA Technical Reports Server (NTRS)

Joiner, Reyann; Kobayashi, Ken; Winebarger, Amy; Champey, Patrick

2014-01-01

The Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP) is a sounding rocket instrument currently being developed by NASA's Marshall Space Flight Center (MSFC), the National Astronomical Observatory of Japan (NAOJ), and other partners. The goal of this instrument is to observe and detect the Hanle effect in the scattered Lyman-Alpha UV (121.6nm) light emitted by the Sun's chromosphere. The polarized spectrum imaged by the CCD cameras will capture information about the local magnetic field, allowing for measurements of magnetic strength and structure. In order to make accurate measurements of this effect, the performance characteristics of the three on- board charge-coupled devices (CCDs) must meet certain requirements. These characteristics include: quantum efficiency, gain, dark current, read noise, and linearity. Each of these must meet predetermined requirements in order to achieve satisfactory performance for the mission. The cameras must be able to operate with a gain of 2.0+/- 0.5 e--/DN, a read noise level less than 25e-, a dark current level which is less than 10e-/pixel/s, and a residual non- linearity of less than 1%. Determining these characteristics involves performing a series of tests with each of the cameras in a high vacuum environment. Here we present the methods and results of each of these performance tests for the CLASP flight cameras.

Three petabytes or bust: planning science observations for NISAR

NASA Astrophysics Data System (ADS)

Doubleday, Joshua R.

2016-05-01

The National Aeronautics and Space Administration (NASA) and the Indian Space Research Organization (ISRO) have formed a joint agency mission, NASA ISRO Synthetic Aperture Radar (NISAR) to fly in the 2020 timeframe, charged with collecting Synthetic Aperture Radar data over nearly all of earth's land and ice, to advance science in ecosystems, solid-earth and cryospheric disciplines with global time-series maps of various phenomenon. Over a three-year mission span, NISAR will collect on the order of 24 Terabits of raw radar data per day. Developing a plan to collect the data necessary for these three primary science disciplines and their sub-disciplines has been challenging in terms of overlapping geographic regions of interest, temporal requirements, competing modes of the radar instrument, and data-volume resources. One of the chief tools in building a plan of observations against these requirements has been a software tool developed at JPL, the Compressed Large-scale Scheduler Planner (CLASP). CLASP intersects the temporo-geometric visibilities of a spaceborne instrument with campaigns of temporospatial maps of scientific interest, in an iterative squeaky-wheel optimization loop. While the overarching strategy for science observations has evolved through the formulation phases of this mission, so has the use of CLASP. We'll show how this problem space and tool has evolved over time, as well as some of the current parameter estimates for NISAR and its overall mission plan.

Development of a Precise Polarization Modulator for UV Spectropolarimetry

NASA Astrophysics Data System (ADS)

Ishikawa, S.; Shimizu, T.; Kano, R.; Bando, T.; Ishikawa, R.; Giono, G.; Tsuneta, S.; Nakayama, S.; Tajima, T.

2015-10-01

We developed a polarization modulation unit (PMU) to rotate a waveplate continuously in order to observe solar magnetic fields by spectropolarimetry. The non-uniformity of the PMU rotation may cause errors in the measurement of the degree of linear polarization (scale error) and its angle (crosstalk between Stokes-Q and -U), although it does not cause an artificial linear polarization signal (spurious polarization). We rotated a waveplate with the PMU to obtain a polarization modulation curve and estimated the scale error and crosstalk caused by the rotation non-uniformity. The estimated scale error and crosstalk were {<} 0.01 % for both. This PMU will be used as a waveplate motor for the Chromospheric Lyman-Alpha SpectroPolarimeter (CLASP) rocket experiment. We confirm that the PMU performs and functions sufficiently well for CLASP.

Energy Efficiency Appliance Standards: Where do we stand, how far can we go and how do we get there? An analysis across several economies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Letschert, Virginie E.; de la Rue du Can, Stephane; McNeil, Michael A.

This paper analyses several potential savings scenarios for minimum energy performance standard (MEPS) and comparable programs for governments participating i n the Super-efficient Equipment and Appliance Deployment (SEAD) Initiative, of the Clean Energy Ministerial, which represent over 60% of primary energy consumption in the world. We compare projected energy savings from the main end uses in the residential sector using three energy efficiency scenarios: (1) recent achievements, (2) cost-effective saving potential, and (3) energy efficiency technical potential. The recent achievement scenario (1) evaluates the future impact of MEPS enacted or under development between 2010 and 2012. The cost-effective potential scenariomore » (2) identifies the maximum potential for energy efficiency that results in net benefits to the consumer. The best available technology scenario (3) re presents the full potential of energy efficiency considering best available technologies as candidates for MEPS and incentive programs. We use the Bottom Up Energy Analysis System (BUENAS), developed by Lawrence Berkeley National Laboratory in collaboration with the Collaborative Labelling and Appliances Standards Program (CLASP), to provide a consistent methodology to com pare the different scenarios. This paper focuses on the main end uses in the residential sector. The comparison of the three scenarios for each economy provides possible opportunities for scaling up current policies or implementing additional policies. This comparison across economies reveals country best practices as well as end uses that present the greatest additional potential savings. The paper describes areas where methodologies and additional policy instruments can increase penetration of energy efficient technologies. First , we summarize the barriers and provide remedial policy tools/best practices, such as techno-economic analysis, in response to each barriers that prevent economies from capturing the full cost-effective potentials of MEPS (Scenario 1 to 2). Then, we consider the possible complementary policy options, such as incentive pro grams, to reach the full technical potential of energy efficiency in the residential sector (Scenario 2 to 3).« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kubo, M.; Katsukawa, Y.; Suematsu, Y.

High-cadence observations by the slit-jaw (SJ) optics system of the sounding rocket experiment known as the Chromospheric Lyman Alpha Spectropolarimeter (CLASP) reveal ubiquitous intensity disturbances that recurrently propagate in either the chromosphere or the transition region or both at a speed much higher than the speed of sound. The CLASP/SJ instrument provides a time series of two-dimensional images taken with broadband filters centered on the Ly α line at a 0.6 s cadence. The multiple fast-propagating intensity disturbances appear in the quiet Sun and in an active region, and they are clearly detected in at least 20 areas in amore » field of view of 527″ × 527″ during the 5 minute observing time. The apparent speeds of the intensity disturbances range from 150 to 350 km s{sup −1}, and they are comparable to the local Alfvén speed in the transition region. The intensity disturbances tend to propagate along bright elongated structures away from areas with strong photospheric magnetic fields. This suggests that the observed fast-propagating intensity disturbances are related to the magnetic canopy structures. The maximum distance traveled by the intensity disturbances is about 10″, and the widths are a few arcseconds, which are almost determined by a pixel size of 1.″03. The timescale of each intensity pulse is shorter than 30 s. One possible explanation for the fast-propagating intensity disturbances observed by CLASP is magnetohydrodynamic fast-mode waves.« less

Precision attachments for the partially dentate mouth

PubMed Central

Preiskel, H W

1974-01-01

Some uses of precision attachments in restoring the partially dentate mouth are considered. These devices are indicated where neither the clasp-retained denture nor the fixed bridge is entirely suitable. ImagesFig. 2 PMID:4614689

Resilient Attachments as an Alternative to Conventional Cast Clasp Removable Partial Denture: 3-Year Follow-up.

PubMed

Schuh, Cristian; Adiel Skupien, Jovito; Mesko, Mauro Elias; Valentini, Fernanda; Pereira-Cenci, Tatiana; Boscato, Noéli

2014-12-01

The present clinical report describes the prosthodontic management for a patient with uncontrolled bleeding and diabetes mellitus treated with a maxillary complete denture and a mandibular partial fixed dental prosthesis designed to interface with a removable cast framework partial denture retained by 2 ERA attachments. This approach was undertaken to improve both retention and stability of the distal extension Kennedy Class I removable partial denture. The rehabilitation provided better anterior esthetics than if treated with a conventional clasp retained removable partial denture, by employing a simple, practical design and offering a significant biomechanical advantages, restoring both oral health and function. Thus, this treatment modality, involving an ERA system and transfixation in fixed crowns, is an effective treatment and can be indicated as a clinical alternative for edentulous and partially edentulous patients with systemic disorders or for patients in economic situations that might preclude implant-based rehabilitation.

Designing cobalt chromium removable partial dentures for patients with shortened dental arches: a pilot survey.

PubMed

Nassani, M Z; Devlin, H; Tarakji, B; McCord, J F

2011-08-01

The aim of this survey was to investigate the quality of prescription for the fabrication of cobalt chromium removable partial dentures (RPDs) that are used to extend the shortened dental arches (SDAs). A survey of four commercial dental laboratories located in northern England was conducted. The target of this survey was cobalt chromium RPDs that were requested to restore SDAs comprising the anterior teeth and 2-4 premolars. Dentists' prescriptions were scrutinised, and a special data collection form was completed accordingly. A total of 94 dentists' prescriptions and associated SDA casts were examined. Almost all the requested cobalt chromium RPDs were clasp-retained RPDs (97%). Scrutinising the 91 prescriptions for clasp-retained cobalt chromium RPDs showed that dentists' prescriptions did not have any instructions about the design of the partial denture in a considerable proportion of the cases (32%). Teeth to be clasped were identified clearly in 45% of the prescriptions. A majority of the dentists (64%) failed to provide any instructions about the design of the rests to be placed on the most posterior premolar abutment teeth. A considerable proportion of the dentists delegated the task of selecting the type of the major connector to the dental technician (41%). Only 21 (23%) of the examined casts had clearly defined rest seat preparation. The outcome of this pilot survey shows inadequate quality of prescription in designing RPDs for patients with SDAs. This finding has an ethical and clinical bearing and does not fit with current legal guidelines relevant to designing RPDs. © 2010 Blackwell Publishing Ltd.

Comparison of Solar Fine Structure Observed Simultaneously in Lyα and Mg II h

NASA Astrophysics Data System (ADS)

Schmit, D.; Sukhorukov, A. V.; De Pontieu, B.; Leenaarts, J.; Bethge, C.; Winebarger, A.; Auchère, F.; Bando, T.; Ishikawa, R.; Kano, R.; Kobayashi, K.; Narukage, N.; Trujillo Bueno, J.

2017-10-01

The Chromospheric Lyman Alpha Spectropolarimeter (CLASP) observed the Sun in H I Lyα during a suborbital rocket flight on 2015 September 3. The Interface Region Imaging Telescope (IRIS) coordinated with the CLASP observations and recorded nearly simultaneous and co-spatial observations in the Mg II h and k lines. The Mg II h and Lyα lines are important transitions, energetically and diagnostically, in the chromosphere. The canonical solar atmosphere model predicts that these lines form in close proximity to each other and so we expect that the line profiles will exhibit similar variability. In this analysis, we present these coordinated observations and discuss how the two profiles compare over a region of quiet Sun at viewing angles that approach the limb. In addition to the observations, we synthesize both line profiles using a 3D radiation-MHD simulation. In the observations, we find that the peak width and the peak intensities are well correlated between the lines. For the simulation, we do not find the same relationship. We have attempted to mitigate the instrumental differences between IRIS and CLASP and to reproduce the instrumental factors in the synthetic profiles. The model indicates that formation heights of the lines differ in a somewhat regular fashion related to magnetic geometry. This variation explains to some degree the lack of correlation, observed and synthesized, between Mg II and Lyα. Our analysis will aid in the definition of future observatories that aim to link dynamics in the chromosphere and transition region.

Comparison of Solar Fine Structure Observed Simultaneously in Ly α and Mg ii h

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schmit, D.; Sukhorukov, A. V.; Leenaarts, J.

The Chromospheric Lyman Alpha Spectropolarimeter (CLASP) observed the Sun in H i Ly α during a suborbital rocket flight on 2015 September 3. The Interface Region Imaging Telescope ( IRIS ) coordinated with the CLASP observations and recorded nearly simultaneous and co-spatial observations in the Mg ii h and k lines. The Mg ii h and Ly α lines are important transitions, energetically and diagnostically, in the chromosphere. The canonical solar atmosphere model predicts that these lines form in close proximity to each other and so we expect that the line profiles will exhibit similar variability. In this analysis, wemore » present these coordinated observations and discuss how the two profiles compare over a region of quiet Sun at viewing angles that approach the limb. In addition to the observations, we synthesize both line profiles using a 3D radiation-MHD simulation. In the observations, we find that the peak width and the peak intensities are well correlated between the lines. For the simulation, we do not find the same relationship. We have attempted to mitigate the instrumental differences between IRIS and CLASP and to reproduce the instrumental factors in the synthetic profiles. The model indicates that formation heights of the lines differ in a somewhat regular fashion related to magnetic geometry. This variation explains to some degree the lack of correlation, observed and synthesized, between Mg ii and Ly α . Our analysis will aid in the definition of future observatories that aim to link dynamics in the chromosphere and transition region.« less

Pathways to policy: Lessons learned in multisectoral collaboration for physical activity and built environment policy development from the Coalitions Linking Action and Science for Prevention (CLASP) initiative.

PubMed

Politis, Christopher E; Mowat, David L; Keen, Deb

2017-06-16

The Canadian Partnership Against Cancer funded 12 large-scale knowledge to action cancer and chronic disease prevention projects between 2009 and 2016 through the Coalitions Linking Action and Science for Prevention (CLASP) initiative. Two projects, Healthy Canada by Design (HCBD) and Children's Mobility, Health and Happiness (CMHH), developed policies to address physical activity and the built environment through a multisectoral approach. A qualitative analysis involving a review of 183 knowledge products and 8 key informant interviews was conducted to understand what policy changes occurred, and the underlying critical success factors, through these projects. Both projects worked at the local level to change physical activity and built environment policy in 203 sites, including municipalities and schools. Both projects brought multisectoral expertise (e.g., public health, land use planning, transportation engineering, education, etc.) together to inform the development of local healthy public policy in the areas of land use, transportation and school travel planning. Through the qualitative analysis of the knowledge products and key informant interviews, 163 policies were attributed to HCBD and CMHH work. Fourteen "pathways to policy" were identified as critical success factors facilitating and accelerating the development and implementation of physical activity and built environment policy. Of the 14 pathways to policy, 8 had a focus on multisectoral collaboration. The lessons learned from the CLASP experience could support enhanced multisectoral collaborations to accelerate the development and implementation of physical activity and built environment policy in new jurisdictions across Canada and internationally.

CLASP/SJ Observations of Rapid Time Variations in the Ly α Emission in a Solar Active Region

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ishikawa, Shin-nosuke; Kubo, Masahito; Katsukawa, Yukio

The Chromospheric Ly α SpectroPolarimeter (CLASP) is a sounding rocket experiment launched on 2015 September 3 to investigate the solar chromosphere and transition region. The slit-jaw (SJ) optical system captured Ly α images with a high time cadence of 0.6 s. From the CLASP/SJ observations, many variations in the solar chromosphere and transition region emission with a timescale of <1 minute were discovered. In this paper, we focus on the active region within the SJ field of view and investigate the relationship between short (<30 s) temporal variations in the Ly α emission and the coronal structures observed by Solarmore » Dynamics Observatory/Atmospheric Imaging Assembly (AIA). We compare the Ly α temporal variations at the coronal loop footpoints observed in the AIA 211 Å (≈2 MK) and AIA 171 Å (≈0.6 MK) channels with those in the regions with bright Ly α features without a clear association with the coronal loop footpoints. We find more short (<30 s) temporal variations in the Ly α intensity in the footpoint regions. Those variations did not depend on the temperature of the coronal loops. Therefore, the temporal variations in the Ly α intensity at this timescale range could be related to the heating of the coronal structures up to temperatures around the sensitivity peak of 171 Å. No signature was found to support the scenario that these Ly α intensity variations were related to the nanoflares. Waves or jets from the lower layers (lower chromosphere or photosphere) are possible causes for this phenomenon.« less

Retention strength of cobalt-chromium vs nickel-chromium titanium vs CP titanium in a cast framework association of removable partial overdenture.

PubMed

Souza, Jose Everaldo de Aquino; Silva, Nelson Renato Franca Alves da; Coelho, Paulo Guilherme; Zavanelli, Adriana Cristina; Ferracioli, Renata Cristina Silveira Rodrigues; Zavanelli, Ricardo Alexandre

2011-05-01

There is little information considering the framework association between cast clasps and attachments. The aim of this study was to evaluate the retention strength of frameworks match circumferential clasps and extra resilient attachment cast in three different alloys (cobalt-chromium, nickel-chromium titanium and commercially pure titanium), using two undercut (0.25 and 0.75 mm) and considering different period of time (0, 1/2, 1, 2, 3, 4 and 5 years). Using two metallic matrices, representing a partially edentulous mandibular right hemiarch with the first molar crown, canine root and without premolars, 60 frameworks were fabricated. Three groups (n = 20) of each metal were cast and each group was divided into two subgroups (n = 10), corresponding the molar undercut of 0.25 mm and 0.75 mm. The nylon male was positioned at the matrix and attached to the acrylic resin of the prosthetic base. The samples were subjected to an insertion and removal test under artificial saliva environment. The data were analyzed and compared with ANOVAs and Tukey's test at 95% of probability. The groups cast in cobaltchromium and nickel-chromium-titanium had the highest mean retention strength (5.58 N and 6.36 N respectively) without significant difference between them, but statistically different from the group cast in commercially pure titanium, which had the lowest mean retention strength in all the periods (3.46 N). The association frameworks using nickel-chromium- titanium and cobalt-chromium could be used with 0.25 mm and 0.75 mm of undercut, but the titanium samples seems to decrease the retention strength, mainly in the 0.75 mm undercut. The circumferential clasps cast in commercially pure titanium used in 0.75 mm undercuts have a potential risk of fractures, especially after the 2nd year of use. This in vitro study showed that the framework association between cast clasp and an extra resilient attachment are suitable to the three metals evaluated, but strongly suggest extra care with commercially pure titanium in undercut of 0.75 mm. Frameworks fabricated in Cp Ti tend to decrease in retentive strength over time and have a potential risk of fracture in less than 0.75 mm of undercut.

Oral health-related quality of life in patients with non-metal clasp dentures: a randomised cross-over trial.

PubMed

Fueki, K; Yoshida-Kohno, E; Wakabayashi, N

2017-05-01

We investigated the efficacy of non-metal clasp dentures (NMCDs) with regard to the oral health-related quality of life (OHRQoL) and compare the findings with those for conventional metal clasp-retained dentures (MCDs). This single-centre, randomised controlled, two-phase, open label, cross-over trial included 28 partially dentate individuals. The patients were randomised to receive MCDs followed by NMCDs, or the opposite sequence (n = 14 in each group); each denture was worn for 3 months. OHRQoL was evaluated using the Oral Health Impact Profile-Japanese version (OHIP-J) at entry (T-entry; before treatment with the first denture) and at 3 months after treatment with each denture (T3). An examiner evaluated denture stability, oral appearance and surface roughness before denture delivery (T0) and at T3 and denture hygiene at T3. A total of 24 patients completed the trial. There were no complications related to the dentures, abutment teeth or denture-bearing mucosa during the follow-up periods for both dentures. The mean OHIP summary score was lower for NMCDs than for MCDs, and the difference (9 points) was greater than the minimal important difference (6 points), indicating the difference was clinically relevant. The effect size was medium (0·70). Statistical analyses with linear mixed models found a significant effect of the denture type on the OHIP summary score and scores for the Oro-facial appearance, Oro-facial pain and Psychological impact domains (NMCD < MCD; P < 0·05). The results of our study suggest that NMCDs allow for better OHRQoL compared with MCDs. © 2017 John Wiley & Sons Ltd.

Expression of serotonin receptors in human lower esophageal sphincter

PubMed Central

LI, HE-FEI; LIU, JUN-FENG; ZHANG, KE; FENG, YONG

2015-01-01

Serotonin (5-HT) is a neurotransmitter and vasoactive amine that is involved in the regulation of a large number of physiological functions. The wide variety of 5-HT-mediated functions is due to the existence of different classes of serotonergic receptors in the mammalian gastrointestinal tract and nervous system. The aim of this study was to explore the expression of multiple types of 5-HT receptor (5-HT1AR, 5-HT2AR, 5-HT3AR, 5-HT4R, 5-HT5AR, 5-HT6R and 5-HT7R) in sling and clasp fibers from the human lower esophageal sphincter (LES). Muscle strips of sling and clasp fibers from the LES were obtained from patients undergoing esophagogastrectomy, and circular muscle strips from the esophagus and stomach were used as controls. Reverse transcription-polymerase chain reaction (RT-PCR), quantitative PCR and western blotting were used to investigate the expression of the various 5-HT receptor types. Messenger RNA for all seven 5-HT receptor types was identified in the sling and clasp fibers of the LES. At the mRNA level, the expression levels were highest for 5-HT3AR and 5-HT4R, and lowest for 5-HT5AR, 5-HT6R and 5-HT7R. At the protein level, the expression levels were highest for 5-HT3AR and 5-HT4R, followed by 5-HT1AR and 5-HT2AR; 5-HT7R was also detected at a low level. The expression of 5-HT5AR and 5-HT6R proteins was not confirmed. The results indicate that a variety of 5-HT receptor types can be detected in the human LES and probably contribute to LES function. PMID:25452775

Isolation of the mite Myocoptes musculinus Koch from the Spinifex Hopping mouse (Notomys alexis).

PubMed

Old, J M; Hill, N J; Deane, E M

2007-04-01

This paper reports on the isolation and identification of the fur-clasping mite, Myocoptes musculinus, from the faeces of the Spinifex Hopping mouse (Notomys alexis). This investigation adds to the sparse records of ectoparasites collected from native Australian murids.

Ubiquitous Fast Propagating Intensity Disturbances in Solar Chromosphere

NASA Technical Reports Server (NTRS)

Kubo, M.; Katsukawa, Y.; Suematsu, Y.; Kano, R.; Bando, T.; Narukage, N.; Ishikawa, R.; Hara, H.; Giono, G.; Winebarger, A.;

The Consortium for Higher Education Tax Reform Report

ERIC Educational Resources Information Center

Center for Postsecondary and Economic Success, 2014

2014-01-01

This White Paper presents the work of the Consortium for Higher Education Tax Reform, a partnership funded by the Bill & Melinda Gates Foundation as part of the second phase of its Reimagining Aid Design and Delivery (RADD) initiative. Consortium partners are the Center for Postsecondary and Economic Success at CLASP, the Education Trust, New…

Intraspecific non-sexual interactions of Grammostola schulzei (Araneae: Theraphosidae) under laboratory conditions.

PubMed

Ferretti, Nelson E; Pérez-Miles, Fernando

2011-09-01

Intraspecific interactions of araneomorph spiders have received considerable attention, but there are few detailed studies on intraspecific interactions of mygalomorph spiders. Moreover, a thorough understanding of theraphosid biology and ecology is necessary from a conservation standpoint because natural populations may be threatened by habitat disturbances and captures for pet commerce. We described the behavior of conspecific individuals of Grammostola schulzei during non-sexual interactions, under laboratory conditions. Pairs of individuals involving adult males, adult females and juveniles were confronted and observed in resident and intruder conditions, totalizing 115 trials. When confronted two adult females, they retreated or grappled, and performed gaping display with bite attempts, usually resulted in severe injury of the intruder spiders. When confronted females with large juveniles, we frequently observed cannibalism on juveniles. Juveniles exposed to females or to other juveniles retreated or made leg tapping with forelegs and palpal drumming, which are common displays of courting adult males. Adult males courted and clasped some juveniles, but juveniles avoided or reject clasping. The behaviors observed during intraspecific interactions could play an important role determining spatial distribution and could lead to behavioral adaptations of territoriality.

Comparative study of two commercially pure titanium casting methods

PubMed Central

RODRIGUES, Renata Cristina Silveira; FARIA, Adriana Claudia Lapria; ORSI, Iara Augusta; de MATTOS, Maria da Gloria Chiarello; MACEDO, Ana Paula; RIBEIRO, Ricardo Faria

2010-01-01

The interest in using titanium to fabricate removable partial denture (RPD) frameworks has increased, but there are few studies evaluating the effects of casting methods on clasp behavior. Objective This study compared the occurrence of porosities and the retentive force of commercially pure titanium (CP Ti) and cobalt-chromium (Co-Cr) removable partial denture circumferential clasps cast by induction/centrifugation and plasma/vacuum-pressure. Material and Methods 72 frameworks were cast from CP Ti (n=36) and Co-Cr alloy (n=36; control group). For each material, 18 frameworks were casted by electromagnetic induction and injected by centrifugation, whereas the other 18 were casted by plasma and injected by vacuum-pressure. For each casting method, three subgroups (n=6) were formed: 0.25 mm, 0.50 mm, and 0.75 mm undercuts. The specimens were radiographed and subjected to an insertion/removal test simulating 5 years of framework use. Data were analyzed by ANOVA and Tukey's to compare materials and cast methods (α=0.05). Results Three of 18 specimens of the induction/centrifugation group and 9 of 18 specimens of plasma/vacuum-pressure cast presented porosities, but only 1 and 7 specimens, respectively, were rejected for simulation test. For Co-Cr alloy, no defects were found. Comparing the casting methods, statistically significant differences (p<0.05) were observed only for the Co-Cr alloy with 0.25 mm and 0.50 mm undercuts. Significant differences were found for the 0.25 mm and 0.75 mm undercuts dependent on the material used. For the 0.50 mm undercut, significant differences were found when the materials were induction casted. Conclusion Although both casting methods produced satisfactory CP Ti RPD frameworks, the occurrence of porosities was greater in the plasma/vacuum-pressure than in the induction/centrifugation method, the latter resulting in higher clasp rigidity, generating higher retention force values. PMID:21085805

DOCLASP - Docking ligands to target proteins using spatial and electrostatic congruence extracted from a known holoenzyme and applying simple geometrical transformations.

PubMed

Chakraborty, Sandeep

2014-01-01

The ability to accurately and effectively predict the interaction between proteins and small drug-like compounds has long intrigued researchers for pedagogic, humanitarian and economic reasons. Protein docking methods (AutoDock, GOLD, DOCK, FlexX and Glide to name a few) rank a large number of possible conformations of protein-ligand complexes using fast algorithms. Previously, it has been shown that structural congruence leading to the same enzymatic function necessitates the congruence of electrostatic properties (CLASP). The current work presents a methodology for docking a ligand into a target protein, provided that there is at least one known holoenzyme with ligand bound - DOCLASP (Docking using CLASP). The contact points of the ligand in the holoenzyme defines a motif, which is used to query the target enzyme using CLASP. If there are significant matches, the holoenzyme and the target protein are superimposed based on congruent atoms. The same linear and rotational transformations are also applied to the ligand, thus creating a unified coordinate framework having the holoenzyme, the ligand and the target enzyme. In the current work, the dipeptidyl peptidase-IV inhibitor vildagliptin was docked to the PI-PLC structure complexed with myo-inositol using DOCLASP. Also, corroboration of the docking of phenylthiourea to the modelled structure of polyphenol oxidase (JrPPO1) from walnut is provided based on the subsequently solved structure of JrPPO1 (PDBid:5CE9). Analysis of the binding of the antitrypanosomial drug suramin to nine non-homologous proteins in the PDB database shows a diverse set of binding motifs, and multiple binding sites in the phospholipase A2-likeproteins from the Bothrops genus of pitvipers. The conformational changes in the suramin molecule on binding highlights the challenges in docking flexible ligands into an already 'plastic' binding site. Thus, DOCLASP presents a method for 'soft docking' ligands to proteins with low computational requirements.

Development of Flight Slit-Jaw Optics for Chromospheric Lyman-Alpha SpectroPolarimeter

NASA Technical Reports Server (NTRS)

Kubo, Masahito; Suematsu, Yoshinori; Kano, Ryohei; Bando, Takamasa; Hara, Hirohisa; Narukage, Noriyuki; Katsukawa, Yukio; Ishikawa, Ryoko; Ishikawa, Shin-nosuke; Kobiki, Toshihiko;

High-Reflectivity Multi-Layer Coatings for the CLASP Sounding Rocket Project

NASA Technical Reports Server (NTRS)

Narukage, Noriyuki; Kano, Ryohei; Bando, Takamasa; Ishikawa, Ryoko; Kubo, Masahito; Katsukawa, Yukio; Ishikawa, Shin-nosuke; Kobiki, Toshihiko; Giono, Gabriel; Auchere, Frederic;

Solar Lyman-Alpha Polarization Observation of the Chromosphere and Transition Region by the Sounding Rocket Experiment CLASP

NASA Technical Reports Server (NTRS)

Narukage, Noriyuki; Kano, Ryohei; Bando, Takamasa; Ishikawa, Ryoko; Kubo, Masahito; Katsukawa, Yukio; Ishikawa, Shinnosuke; Hara, Hiroshi; Suematsu, Yoshinori; Giono, Gabriel;

Development of Flight Slit-Jaw Optics for Chromospheric Lyman-Alpha SpectroPolarimeter

NASA Technical Reports Server (NTRS)

Kubo, Masahito; Suematsu, Yoshinori; Kano, Ryohei; Bando, Takamasa; Hara, Hirohisa; Narukage, Noriyuki; Katsukawa, Yukio; Ishikawa, Ryoko; Ishikawa, Shin-nosuke; Kobiki, Toshihiko;

Automated Scheduling of Science Activities for Titan Encounters by Cassini

NASA Technical Reports Server (NTRS)

Ray, Trina L.; Knight, Russel L.; Mohr, Dave

2014-01-01

In an effort to demonstrate the efficacy of automated planning and scheduling techniques for large missions, we have adapted ASPEN (Activity Scheduling and Planning Environment) [1] and CLASP (Compressed Large-scale Activity Scheduling and Planning) [2] to the domain of scheduling high-level science goals into conflict-free operations plans for Titan encounters by the Cassini spacecraft.

Assessing Student Peer Dialogue in Collaborative Settings: A Window into Student Reasoning

ERIC Educational Resources Information Center

Stone, Antoinette

2013-01-01

The use of science classroom discourse analysis as a way to gain a better understanding of various student cognitive outcomes has a rich history in Science Education in general and Physics Education Research (PER) in particular. When students talk to each other in a collaborative peer instruction environment, such as in the CLASP classes…

Ratio Tables to Promote Proportional Reasonings in the Primary Classroom

ERIC Educational Resources Information Center

Dole, Shelley

2008-01-01

There are many classroom activities that can be implemented with primary students that introduce and immerse them in ratio investigations. Some enjoyable tasks include finding the ratio of tongue rollers to non-tongue rollers in the classroom; left-hand dominant to right-hand dominant; right-thumb over left-thumb when clasping the hands to…

Increasing College Attainment in the United States: Variations in Returns to States and Their Residents

ERIC Educational Resources Information Center

Crellin, Matt; Kelly, Patrick; Prince, Heath

2012-01-01

General acceptance of the strong relationships between education, income, and public economic strength is at the core of all of college attainment goals at the national and state levels. The National Center for Higher Education Management Systems (NCHEMS) and the Center for Law and Social Policy (CLASP) have collaborated to develop online tools…

Building Comprehensive State Systems for Vulnerable Babies: A Resource for State Leaders

ERIC Educational Resources Information Center

Center for Law and Social Policy, Inc. (CLASP), 2011

2011-01-01

Center for Law and Social Policy (CLASP) has developed this resource to help state leaders strategize how to create or improve early childhood systems to meet the needs of vulnerable babies and toddlers, their families, and pregnant women. Every state has the pieces of a comprehensive early childhood system in place. This tool will help state…

Questions to Consider When Reviewing Draft WIOA State Plans. WIOA Game Plan for Low-Income People

ERIC Educational Resources Information Center

Center for Law and Social Policy, Inc. (CLASP), 2016

2016-01-01

As states release draft Workforce Innovation and Opportunity Act (WIOA) state plans for public comment, advocates and other stakeholders have an important opportunity to improve them. The Center for Law and Social Policy (CLASP) is offering a list of questions, which is included in this document, to consider when reviewing state plans. These…

Approximate reasoning using terminological models

NASA Technical Reports Server (NTRS)

Yen, John; Vaidya, Nitin

1992-01-01

Term Subsumption Systems (TSS) form a knowledge-representation scheme in AI that can express the defining characteristics of concepts through a formal language that has a well-defined semantics and incorporates a reasoning mechanism that can deduce whether one concept subsumes another. However, TSS's have very limited ability to deal with the issue of uncertainty in knowledge bases. The objective of this research is to address issues in combining approximate reasoning with term subsumption systems. To do this, we have extended an existing AI architecture (CLASP) that is built on the top of a term subsumption system (LOOM). First, the assertional component of LOOM has been extended for asserting and representing uncertain propositions. Second, we have extended the pattern matcher of CLASP for plausible rule-based inferences. Third, an approximate reasoning model has been added to facilitate various kinds of approximate reasoning. And finally, the issue of inconsistency in truth values due to inheritance is addressed using justification of those values. This architecture enhances the reasoning capabilities of expert systems by providing support for reasoning under uncertainty using knowledge captured in TSS. Also, as definitional knowledge is explicit and separate from heuristic knowledge for plausible inferences, the maintainability of expert systems could be improved.

Reforming Student Aid: How to Simplify Tax Aid and Use Performance Metrics to Improve College Choices and Completion

ERIC Educational Resources Information Center

Reimherr, Patrick; Harmon, Tim; Strawn, Julie; Choitz, Vickie

2013-01-01

Any reform of federal student aid must address the twin challenges of college affordability and completion, which are inextricably linked. Here, CLASP has proposed ways to redirect existing federal student aid spending toward the low- and modest income families who need it most. These are the students for whom federal aid makes a difference in…

Plant Guide: Bluebunch wheatgrass: Pseudoroegneria spicata

Treesearch

Daniel G. Ogle; Loren St. John; Thomas A. Jones

2010-01-01

Grass Family (Poaceae). Bluebunch wheatgrass is a perennial native bunchgrass. Bluebunch wheatgrass is highly variable and grows to 1.5 to 4 feet (0.4 to 1.2 m) tall with seed spikes 3 to 8 inches (76 to 200 mm) long. The auricles are pointed and semi-clasping to nearly lacking. Leaves are lax, cauline, flat to in-rolled, 0.6 to 0.25 inches (4 to 6 mm) wide, and green...

[Evaluation method with radiographic image quality indicator for internal defects of dental casting metallic restoration].

PubMed

Li, Y; Zheng, G; Lin, H

2014-12-18

To develop a new kind of dental radiographic image quality indicator (IQI) for internal quality of casting metallic restoration to influence on its usage life. Radiographic image quality indicator method was used to evaluate the depth of the defects region and internal quality of 127 casting metallic restoration and the accuracy was compared with that of conventional callipers method. In the 127 cases of casting metallic restoration, 9 were found the thickness less than 0.7 mm and the thinnest thickness only 0.2 mm in 26 casting metallic crowns or bridges' occlusal defects region. The data measured by image quality indicator were consistent with those measured by conventional gauging. Two metal inner crowns were found the thickness less than 0.3 mm in 56 porcelain crowns or bridges. The thickness of casting removable partial denture was more than 1.0 mm, but thinner regions were not found. It was found that in a titanium partial denture, the X-ray image of clasp was not uniform and there were internal porosity defects in the clasp. Special dental image quality indicator can solve the visual error problems caused by different observing backgrounds and estimate the depth of the defects region in the casting.

Aluminum Manganese Molten Salt Plating

DTIC Science & Technology

2006-06-01

fixture from overhead crane hook and locate fixture over the closed acid tank. 2. Ventilation a. Set valve positions as follows (same as Section I.4.a...overhead crane hook and position the fixture over the closed acid tank. (Will need to remove the top stainless steel rod, clasp the remaining rod with the... crane hook , replace the rod that was removed by threading it through the crane hook , and finally lift the fixture off its storage hook . The cotter

Manipulator for rotating and translating a sample holder

DOEpatents

van de Water, Jeroen [Breugel, NL; van den Oetelaar, Johannes [Eindhoven, NL; Wagner, Raymond [Gorinchem, NL; Slingerland, Hendrik Nicolaas [Venlo, NL; Bruggers, Jan Willem [Eindhoven, NL; Ottevanger, Adriaan Huibert Dirk [Malden, NL; Schmid, Andreas [Berkeley, CA; Olson, Eric A [Champaign, IL; Petrov, Ivan G [Champaign, IL; Donchev, Todor I [Urbana, IL; Duden, Thomas [Kensington, CA

2011-02-08

A manipulator for use in e.g. a Transmission Electron Microscope (TEM) is described, said manipulator capable of rotating and translating a sample holder (4). The manipulator clasps the round sample holder between two members (3A, 3B), said members mounted on actuators (2A, 2B). Moving the actuators in the same direction results in a translation of the sample holder, while moving the actuators in opposite directions results in a rotation of the sample holder.

A secondary copulatory structure in a female insect: a clasp for a nuptial meal?

NASA Astrophysics Data System (ADS)

Gwynne, Darryl T.

2002-03-01

Secondary copulatory structures are well-known in male dragonflies and spiders. Here I report a secondary copulatory organ in female ground weta, Hemiandrus pallitarsis (Ensifera, Orthoptera - crickets and allies). The organ, located on the underside of the abdomen, appears to secure the male's genitalia during the transfer of a spermatophylax nuptial meal to this location, an area quite separate from the female's primary copulatory structures, where the sperm ampulla is attached.

jsc2012e239101

NASA Image and Video Library

2012-11-30

At the Gagarin Cosmonaut Training Center in Star City, Russia, the Expedition 34/35 prime crew clasps hands at the conclusion of a news conference Nov. 29, 2012 as they complete preparations for launch Dec. 19 to the International Space Station in their Soyuz TMA-07M spacecraft from the Baikonur Cosmodrome in Kazakhstan. From left to right are NASA Flight Engineer Tom Marshburn, Soyuz Commander Roman Romanenko and Flight Engineer Chris Hadfield of the Canadian Space Agency. NASA/Stephanie Stoll

Full 3-dimensional digital workflow for multicomponent dental appliances: A proof of concept.

PubMed

van der Meer, W Joerd; Vissink, Arjan; Ren, Yijin

2016-04-01

The authors used a 3-dimensional (3D) printer and a bending robot to produce a multicomponent dental appliance to assess whether 3D digital models of the dentition are applicable for a full digital workflow. The authors scanned a volunteer's dentition with an intraoral scanner (Lava Chairside Oral Scanner C.O.S., 3M). A digital impression was used to design 2 multicomponent orthodontic appliances. Biocompatible acrylic baseplates were produced with the aid of a 3D printer. The metal springs and clasps were produced by a bending robot. The fit of the 2 appliances was assessed by 2 experienced orthodontists. The authors assessed both orthodontic appliances with the volunteer's dentition and found the fit to be excellent. Clinicians can fully produce a multicomponent dental appliance consisting of both an acrylic baseplate and other parts, such as clasps, springs, or screws, using a digital workflow process without the need for a physical model of the patient's dentition. Plaster models can be superfluous for orthodontic treatment as digital models can be used in all phases of a full digital workflow in orthodontics. The arduous task of making a multicomponent dental appliance that involves bending wires can possibly be replaced by a computer, design software, a 3D printer, and a bending robot. Copyright © 2016 American Dental Association. Published by Elsevier Inc. All rights reserved.

Chromospheric Lyman-Alpha SpectroPolarimeter (CLASP)

NASA Technical Reports Server (NTRS)

Kano, Ryohei; Bando, Takamasa; Narukage, Noriyuki; Ishikawa, Ryoko; Kubo, Masahito; Katsukawa, Yukio; Ishikawa, Shin-­nosuke; Hara, Hirohisa; Suematsu, Yoshinori; Giono, Gabriel;

Optical alignment of the Chromospheric Lyman-Alpha Spectro-Polarimeter using sophisticated methods to minimize activities under vacuum

NASA Astrophysics Data System (ADS)

Giono, G.; Katsukawa, Y.; Ishikawa, R.; Narukage, N.; Kano, R.; Kubo, M.; Ishikawa, S.; Bando, T.; Hara, H.; Suematsu, Y.; Winebarger, A.; Kobayashi, K.; Auchère, F.; Trujillo Bueno, J.

2016-07-01

The Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP) is a sounding-rocket instrument developed at the National Astronomical Observatory of Japan (NAOJ) as a part of an international collaboration. The instrument main scientific goal is to achieve polarization measurement of the Lyman-α line at 121.56 nm emitted from the solar upper-chromosphere and transition region with an unprecedented 0.1% accuracy. The optics are composed of a Cassegrain telescope coated with a "cold mirror" coating optimized for UV reflection and a dual-channel spectrograph allowing for simultaneous observation of the two orthogonal states of polarization. Although the polarization sensitivity is the most important aspect of the instrument, the spatial and spectral resolutions of the instrument are also crucial to observe the chromospheric features and resolve the Ly-α profiles. A precise alignment of the optics is required to ensure the resolutions, but experiments under vacuum conditions are needed since Ly-α is absorbed by air, making the alignment experiments difficult. To bypass this issue, we developed methods to align the telescope and the spectrograph separately in visible light. We explain these methods and present the results for the optical alignment of the CLASP telescope and spectrograph. We then discuss the combined performances of both parts to derive the expected resolutions of the instrument, and compare them with the flight observations performed on September 3rd 2015.

The mitosis-regulating and protein-protein interaction activities of astrin are controlled by aurora-A-induced phosphorylation.

PubMed

Chiu, Shao-Chih; Chen, Jo-Mei Maureen; Wei, Tong-You Wade; Cheng, Tai-Shan; Wang, Ya-Hui Candice; Ku, Chia-Feng; Lian, Chiao-Hsuan; Liu, Chun-Chih Jared; Kuo, Yi-Chun; Yu, Chang-Tze Ricky

2014-09-01

Cells display dramatic morphological changes in mitosis, where numerous factors form regulatory networks to orchestrate the complicated process, resulting in extreme fidelity of the segregation of duplicated chromosomes into two daughter cells. Astrin regulates several aspects of mitosis, such as maintaining the cohesion of sister chromatids by inactivating Separase and stabilizing spindle, aligning and segregating chromosomes, and silencing spindle assembly checkpoint by interacting with Src kinase-associated phosphoprotein (SKAP) and cytoplasmic linker-associated protein-1α (CLASP-1α). To understand how Astrin is regulated in mitosis, we report here that Astrin acts as a mitotic phosphoprotein, and Aurora-A phosphorylates Astrin at Ser(115). The phosphorylation-deficient mutant Astrin S115A abnormally activates spindle assembly checkpoint and delays mitosis progression, decreases spindle stability, and induces chromosome misalignment. Mechanistic analyses reveal that Astrin phosphorylation mimicking mutant S115D, instead of S115A, binds and induces ubiquitination and degradation of securin, which sequentially activates Separase, an enzyme required for the separation of sister chromatids. Moreover, S115A fails to bind mitosis regulators, including SKAP and CLASP-1α, which results in the mitotic defects observed in Astrin S115A-transfected cells. In conclusion, Aurora-A phosphorylates Astrin and guides the binding of Astrin to its cellular partners, which ensures proper progression of mitosis. Copyright © 2014 the American Physiological Society.

Structure and immune recognition of trimeric pre-fusion HIV-1 Env

DOE PAGES

Pancera, Marie; Zhou, Tongqing; Druz, Aliaksandr; ...

2014-10-08

The human immunodeficiency virus type 1 (HIV-1) envelope (Env) spike, comprising three gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by rearranging from a mature unliganded state, through receptor-bound intermediates, to a post-fusion state. As the sole viral antigen on the HIV-1 virion surface, Env is both the target of neutralizing antibodies and a focus of vaccine efforts. Here we report the structure at 3.5 Å resolution for an HIV-1 Env trimer captured in a mature closed state by antibodies PGT122 and 35O22. This structure reveals the pre-fusion conformation of gp41, indicates rearrangements needed formore » fusion activation, and defines parameters of immune evasion and immune recognition. Pre-fusion gp41 encircles amino- and carboxy-terminal strands of gp120 with four helices that form a membrane-proximal collar, fastened by insertion of a fusion peptide-proximal methionine into a gp41-tryptophan clasp. Spike rearrangements required for entry involve opening the clasp and expelling the termini. In conclusion, N-linked glycosylation and sequence-variable regions cover the pre-fusion closed spike; we used chronic cohorts to map the prevalence and location of effective HIV-1-neutralizing responses, which were distinguished by their recognition of N-linked glycan and tolerance for epitope-sequence variation.« less

Structure and immune recognition of trimeric pre-fusion HIV-1 Env

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pancera, Marie; Zhou, Tongqing; Druz, Aliaksandr

The human immunodeficiency virus type 1 (HIV-1) envelope (Env) spike, comprising three gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by rearranging from a mature unliganded state, through receptor-bound intermediates, to a post-fusion state. As the sole viral antigen on the HIV-1 virion surface, Env is both the target of neutralizing antibodies and a focus of vaccine efforts. Here we report the structure at 3.5 Å resolution for an HIV-1 Env trimer captured in a mature closed state by antibodies PGT122 and 35O22. This structure reveals the pre-fusion conformation of gp41, indicates rearrangements needed formore » fusion activation, and defines parameters of immune evasion and immune recognition. Pre-fusion gp41 encircles amino- and carboxy-terminal strands of gp120 with four helices that form a membrane-proximal collar, fastened by insertion of a fusion peptide-proximal methionine into a gp41-tryptophan clasp. Spike rearrangements required for entry involve opening the clasp and expelling the termini. In conclusion, N-linked glycosylation and sequence-variable regions cover the pre-fusion closed spike; we used chronic cohorts to map the prevalence and location of effective HIV-1-neutralizing responses, which were distinguished by their recognition of N-linked glycan and tolerance for epitope-sequence variation.« less

Nonrandom γ-TuNA-dependent spatial pattern of microtubule nucleation at the Golgi

PubMed Central

Sanders, Anna A. W. M.; Chang, Kevin; Zhu, Xiaodong; Thoppil, Roslin J.; Holmes, William R.; Kaverina, Irina

2017-01-01

Noncentrosomal microtubule (MT) nucleation at the Golgi generates MT network asymmetry in motile vertebrate cells. Investigating the Golgi-derived MT (GDMT) distribution, we find that MT asymmetry arises from nonrandom nucleation sites at the Golgi (hotspots). Using computational simulations, we propose two plausible mechanistic models of GDMT nucleation leading to this phenotype. In the “cooperativity” model, formation of a single GDMT promotes further nucleation at the same site. In the “heterogeneous Golgi” model, MT nucleation is dramatically up-regulated at discrete and sparse locations within the Golgi. While MT clustering in hotspots is equally well described by both models, simulating MT length distributions within the cooperativity model fits the data better. Investigating the molecular mechanism underlying hotspot formation, we have found that hotspots are significantly smaller than a Golgi subdomain positive for scaffolding protein AKAP450, which is thought to recruit GDMT nucleation factors. We have further probed potential roles of known GDMT-promoting molecules, including γ-TuRC-mediated nucleation activator (γ-TuNA) domain-containing proteins and MT stabilizer CLASPs. While both γ-TuNA inhibition and lack of CLASPs resulted in drastically decreased GDMT nucleation, computational modeling revealed that only γ-TuNA inhibition suppressed hotspot formation. We conclude that hotspots require γ-TuNA activity, which facilitates clustered GDMT nucleation at distinct Golgi sites. PMID:28931596

[Artistic representation of the female breast as an attribute of femininity and fertility and also the origin of life force and wisdom].

PubMed

Kirchhoff, H

1990-03-01

The artistic representation of the female breasts is based upon two totally independent concepts, which are different in their expression. On the one hand, the figure, clasping her hands around her breasts, stands for womanliness and fertility. On the other hand, the act of voiding milk or water, symbolizes donation of or wisdom. These two functions of the female breasts are a large number of illustrations.

Plant Community Response in Small Plots One Year after Treatment with Triclopyr and Endothall in Noxon Rapids Reservoir, MT, 2011

DTIC Science & Technology

2011-11-01

SAS Institute Inc., Cary , NC, USA. Wersal, R.M., J.D. Madsen, B.R. McMillan and P.D. Gerard. 2006. Environmental factors affecting biomass and...Eurasian watermilfoil 50 16* 12* Potamogeton crispus Curlyleaf pondweed 81 50* 67 Potamogeton foliosus Leafy pondweed 31 16 42 Potamogeton illinoensis ...foliosus Leafy pondweed 11 0* 19 Potamogeton illinoensis Illinois pondweed 3 0 0 Potamogeton richardsonii Clasping-leaved pondweed 31 3* 3

The clinical spectrum of mutations in L1, a neuronal cell adhesion molecule

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fransen, E.; Vits, L.; Van Camp, G.

1996-07-12

Mutations in the gene encoding the neuronal cell adhesion molecule L1 are responsible for several syndromes with clinical overlap, including X-linked hydrocephalus (XLH, HSAS), MASA (mental retardation, aphasia, shuffling gait, adducted thumbs) syndrome, complicated X-linked spastic paraplegia (SP 1), X-linked mental retardation-clasped thumb (MR-CT) syndrome, and some forms of X-linked agenesis of the corpus callosum (ACC). We review 34 L1 mutations in patients with these phenotypes. 22 refs., 3 figs., 4 tabs.

jsc2012e238680

NASA Image and Video Library

2012-11-28

The next trio of residents that will launch to the International Space Station clasp hands for reporters and photojournalists at the Gagarin Cosmonaut Training Center in Star City, Russia Nov. 28, 2012 during the second of two days of flight qualification exams. Expedition 34/35 Flight Engineer Chris Hadfield of the Canadian Space Agency (left), Soyuz Commander Roman Romanenko (center) and NASA Flight Engineer Tom Marshburn (right) are scheduled to launch Dec. 19 from the Baikonur Cosmodrome in Kazakhstan on the Soyuz TMA-07M spacecraft. NASA/Stephanie Stoll

Sex-specific rejection in mate-guarding pair formation in the intertidal copepod, Tigriopus californicus

PubMed Central

Burton, Ronald S.

2017-01-01

Securing a potential mate is one of the most important processes in sexual reproduction of animals. Intertidal copepods of the genus Tigriopus show mate-guarding behavior where a male captures a female and continues to clasp her for up to two weeks prior to copulation. Although these copepods form a mate-guarding pair between a male and a female with high accuracy, interactions between the sexes in pair formation have not been well described and the mechanism allowing successful male-female pair formation is not yet understood. In this study, we performed experiments with Tigriopus californicus to analyze the behavior of both a capturer (male) and a captured individual (female or male) in formation of a guarding pair. While capturer males were attracted by both females and males, capture of virgin males was terminated in a significantly shorter time than that of virgin females. However, when presented freshly killed females or males, regardless of the sex of the body, capturer males continued to clasp the body for a comparable time as in an attempt on a living female. Our results suggest that a sex-specific rejection signal actively sent by captured males prevents male-male pair formation. Experiments also suggest that mated females reject an attempt of pair formation. To our knowledge, this is the first study to suggest involvement of active rejection by a captured individual in facilitation of reproductively successful male-female guarding pair formation in the genus Tigriopus. PMID:28832683

A lack of association between polymorphisms of three positional candidate genes (CLASP2 , UBP1, and FBXL2) and canine disorder of sexual development (78,XX; SRY -negative).

PubMed

Salamon, Sylwia; Nowacka-Woszuk, Joanna; Szczerbal, Izabela; Dzimira, Stanisław; Nizanski, Wojciech; Ochota, Malgorzata; Switonski, Marek

2014-01-01

A disorder of sexual development (DSD) of dogs with a female karyotype, missing SRY gene, and presence of testicles or ovotestes is quite commonly diagnosed. It is suggested that this disorder is caused by an autosomal recessive mutation; however, other models of inheritance have not been definitely ruled out. In an earlier study it was hypothesized that the mutation may reside in a pericentromeric region of canine chromosome 23 (CFA23). Three positional candidate genes (CLASP2, UBP1, and FBXL2) were selected in silico in the search for polymorphisms in 7 testicular or ovotesticular XX DSD dogs, 8 XX DSD dogs of unknown cause (SRY-negative, with enlarged clitoris and unknown histology of gonads), and 29 normal female dogs as a control group. Among the 15 molecularly studied dogs with enlarged clitoris there were 3 new cases of testicular or ovotesticular XX DSD and 4 new cases of XX DSD with unknown cause (histology of the gonads unknown). Altogether, 11 (including 10 novel) polymorphisms in 5'- and 3'-flanking regions of the studied genes were found. The distribution analysis of these polymorphisms showed no association with the DSD phenotypes. Thus, it was concluded that the presence of the causative mutation for testicular or ovotesticular XX DSD in the pericentromeric region of CFA23 is unlikely. © 2014 S. Karger AG, Basel.

Optical Alignment of the Chromospheric Lyman-Alpha SpectroPolarimeter using Sophisticated Methods to Minimize Activities under Vacuum

NASA Technical Reports Server (NTRS)

Giono, G.; Katsukawa, Y.; Ishikawa, R.; Narukage, N.; Kano, R.; Kubo, M.; Ishikawa, S.; Bando, T.; Hara, H.; Suematsu, Y.;

Discovery of Scattering Polarization in the Hydrogen Lyα Line of the Solar Disk Radiation

NASA Astrophysics Data System (ADS)

Kano, R.; Trujillo Bueno, J.; Winebarger, A.; Auchère, F.; Narukage, N.; Ishikawa, R.; Kobayashi, K.; Bando, T.; Katsukawa, Y.; Kubo, M.; Ishikawa, S.; Giono, G.; Hara, H.; Suematsu, Y.; Shimizu, T.; Sakao, T.; Tsuneta, S.; Ichimoto, K.; Goto, M.; Belluzzi, L.; Štěpán, J.; Asensio Ramos, A.; Manso Sainz, R.; Champey, P.; Cirtain, J.; De Pontieu, B.; Casini, R.; Carlsson, M.

2017-04-01

There is a thin transition region (TR) in the solar atmosphere where the temperature rises from 10,000 K in the chromosphere to millions of degrees in the corona. Little is known about the mechanisms that dominate this enigmatic region other than the magnetic field plays a key role. The magnetism of the TR can only be detected by polarimetric measurements of a few ultraviolet (UV) spectral lines, the Lyα line of neutral hydrogen at 121.6 nm (the strongest line of the solar UV spectrum) being of particular interest given its sensitivity to the Hanle effect (the magnetic-field-induced modification of the scattering line polarization). We report the discovery of linear polarization produced by scattering processes in the Lyα line, obtained with the Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP) rocket experiment. The Stokes profiles observed by CLASP in quiet regions of the solar disk show that the Q/I and U/I linear polarization signals are of the order of 0.1% in the line core and up to a few percent in the nearby wings, and that both have conspicuous spatial variations with scales of ˜10 arcsec. These observations help constrain theoretical models of the chromosphere-corona TR and extrapolations of the magnetic field from photospheric magnetograms. In fact, the observed spatial variation from disk to limb of polarization at the line core and wings already challenge the predictions from three-dimensional magnetohydrodynamical models of the upper solar chromosphere.

Vagal Afferent Innervation of the Lower Esophageal Sphincter

PubMed Central

Powley, Terry L.; Baronowsky, Elizabeth A.; Gilbert, Jared M.; Hudson, Cherie N.; Martin, Felecia N.; Mason, Jacqueline K.; McAdams, Jennifer L.; Phillips, Robert J.

2013-01-01

To supply a fuller morphological characterization of the vagal afferents innervating the lower esophageal sphincter (LES), specifically to label vagal terminals in the tissues forming the LES in the gastroesophageal junction, the present experiment employed injections of dextran biotin into the nodose ganglia of rats. Four types of vagal afferents innervated the LES. Clasp and sling muscle fibers were directly and prominently innervated by intramuscular arrays (IMAs). Individual IMA terminals subtended about 16° of arc of the esophageal circumference, and, collectively, the terminal fields were distributed within the muscle ring to establish a 360° annulus of mechanoreceptors in the sphincter wall. 3D morphometry of the terminals established that, compared to sling muscle IMAs, clasp muscle IMAs had more extensive arbors and larger receptive fields. In addition, at the cardia, local myenteric ganglia between smooth muscle sheets and striated muscle bundles were innervated by intraganglionic laminar endings (IGLEs), in a pattern similar to the innervation of the myenteric plexus throughout the stomach and esophagus. Finally, as previously described, the principle bundle of sling muscle fibers that links LES sphincter tissue to the antropyloric region of the lesser curvature was innervated by exceptionally long IMAs as well as by unique web ending specializations at the distal attachment of the bundle. Overall, the specialized varieties of densely distributed vagal afferents innervating the LES underscore the conclusion that these sensory projections are critically involved in generating LES reflexes and may be promising targets for managing esophageal dysfunctions. PMID:23583280

Hand-Held Keyboard

NASA Technical Reports Server (NTRS)

1994-01-01

The Data Egg, a prototype chord key-based data entry device, can be used autonomously or as an auxiliary keyboard with a personal computer. Data is entered by pressing combinations of seven buttons positioned where the fingers naturally fall when clasping the device. An experienced user can enter text at 30 to 35 words per minute. No transcription is required. The input is downloaded into a computer and printed. The Data Egg can be used by an astronaut in space, a journalist, a bedridden person, etc. It was developed by a Jet Propulsion Laboratory engineer. Product is not currently manufactured.

A new species of Fuziidae (Insecta, Blattida) from the Inner Mongolia, China

PubMed Central

Wei, Dandan; Liang, Junhui; Ren, Dong

2012-01-01

Abstract A new species attributed to the genus Parvifuzia Guo & Ren, 2011, Parvifuzia peregrina sp. n., is described from the Middle Jurassic Jiulongshan Formation of Daohugou Village, Inner Mongolia, China. This new species, with apex of wing almost reaching the end of the abdomen and forewing venation with 30–32 veins at margin, broadens the diversity of Parvifuzia. This new species, with strongly curved cerci, could tightly clasp female and complete copulation more efficiently, same as other members of the family Fuziidae. PMID:22977342

A new species of Parapygmephorus Cross, 1965 (Acari; Heterostigmatina; Neopygmephoridae) phoretic on Halictus quadricinctus (Fabricius, 1776) (Hym.; Halictidae) from Iran.

PubMed

Hajiqanbar, Hamidreza; Khaustov, Alexander; Kamali, Karim

2011-01-01

A new species of the genus Parapygmephorus Cross, 1965 (Acari: Heterostigmatina, Neopygmephoridae) is described from Northeastern Iran. A phoretic adult female of Parapygmephorus khorasanicus Hajiqanbar and Khaustov sp. n. was discovered clasping on hairs on the ventral body surface of Halictus quadricinctus (Fabricius, 1776) (Hymenoptera; Halictidae). It is the fifth representative among the known species of the genus Parapygmephorus in the world. Differentiation of new species from other species of the genus is discussed, and a key to known world species is provided.

Inventory Optimization of USMC Uniforms Through Reverse Logistics

DTIC Science & Technology

2016-05-01

Blouse, Desert, MCCUU wiPermethrin 3 $ 38.86 $ 116.58 8415-01-527-1430 03092 Blouse, Woodland, MCCUU wiPermethrin 2 $ 38.90 $ 77.80 8430-01-591· 1103 ...1 $ 11.66 $ 11.66 8455-01-503- 1103 10054 Clasp, Necktie, Gold Plated 1 $ 1.46 $ 1.46 8405-01-279-5579 02049 Coat, Man’s PolyiWool Gabardne, Green. w...Woodland, MCCUU wiPermethrin 2 $ 38.90 $ 77.80 8430-01-591· 1103 04094 Boot, Rugged All Terrain (RAT), Hot Weather $ 141.70 $ 141.70 8430-01-563-6897 03544

Evaluation of Meteorological and Aerosol Sensing with small Unmanned Aerial Systems

NASA Astrophysics Data System (ADS)

Claussen, Johanna; Möhler, Ottmar; Leisner, Thomas; Brooks, Ian; Norris, Sarah; Brooks, Barbara; Hill, Martin; Haunold, Werner; Schrod, Jann; Danielczok, Anja

2013-04-01

Atmospheric aerosols have a large impact on the climate system due to their influence on the global radiation budget. Local aerosol sources such as vegetation, (bare) soil or industrial sites have to be quantified with high resolution data to validate aerosol transport models and improve the input for high resolution weather models. Our goal is to evaluate the use of Unmanned Aerial Systems (UAS) as a method for acquisition of high resolution meteorological and aerosol data. During the INUIT measurement campaign in August 2012 at mount Großer Feldberg near Frankfurt, Germany, several flights with different sensor packages were carried out. We measured basic meteorological parameters such as temperature, relative humidity and air pressure with miniaturized onboard sensors. In addition, the Compact Lightweight Aerosol Spectrometer Probe (CLASP) for aerosol size distribution measurement or the Electrostatic Aerosol Collector (EAC) for aerosol sample collection was installed on board. CLASP measures aerosol particles with diameters from 0.17 μm to 9.5 μm in up to 32 channels at a frequency of 10 Hz. The EAC collects air samples at 2 l/min onto a sample holder. After the flight the ice nuclei on the sample holder are activated and counted in the isothermal static diffusion chamber FRIDGE. The results from the INUIT campaign and additional calibration laboratory measurements show that UAS are a valuable platform for miniaturized sensors. The number of ice nuclei was determined with the EAC at 200m above ground level and compared to the reference measurement on the ground.

Discovery of Scattering Polarization in the Hydrogen Ly α Line of the Solar Disk Radiation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kano, R.; Narukage, N.; Ishikawa, R.

There is a thin transition region (TR) in the solar atmosphere where the temperature rises from 10,000 K in the chromosphere to millions of degrees in the corona. Little is known about the mechanisms that dominate this enigmatic region other than the magnetic field plays a key role. The magnetism of the TR can only be detected by polarimetric measurements of a few ultraviolet (UV) spectral lines, the Ly α line of neutral hydrogen at 121.6 nm (the strongest line of the solar UV spectrum) being of particular interest given its sensitivity to the Hanle effect (the magnetic-field-induced modification ofmore » the scattering line polarization). We report the discovery of linear polarization produced by scattering processes in the Ly α line, obtained with the Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP) rocket experiment. The Stokes profiles observed by CLASP in quiet regions of the solar disk show that the Q / I and U / I linear polarization signals are of the order of 0.1% in the line core and up to a few percent in the nearby wings, and that both have conspicuous spatial variations with scales of ∼10 arcsec. These observations help constrain theoretical models of the chromosphere–corona TR and extrapolations of the magnetic field from photospheric magnetograms. In fact, the observed spatial variation from disk to limb of polarization at the line core and wings already challenge the predictions from three-dimensional magnetohydrodynamical models of the upper solar chromosphere.« less

A computational module assembled from different protease family motifs identifies PI PLC from Bacillus cereus as a putative prolyl peptidase with a serine protease scaffold.

PubMed

Rendón-Ramírez, Adela; Shukla, Manish; Oda, Masataka; Chakraborty, Sandeep; Minda, Renu; Dandekar, Abhaya M; Ásgeirsson, Bjarni; Goñi, Félix M; Rao, Basuthkar J

2013-01-01

Proteolytic enzymes have evolved several mechanisms to cleave peptide bonds. These distinct types have been systematically categorized in the MEROPS database. While a BLAST search on these proteases identifies homologous proteins, sequence alignment methods often fail to identify relationships arising from convergent evolution, exon shuffling, and modular reuse of catalytic units. We have previously established a computational method to detect functions in proteins based on the spatial and electrostatic properties of the catalytic residues (CLASP). CLASP identified a promiscuous serine protease scaffold in alkaline phosphatases (AP) and a scaffold recognizing a β-lactam (imipenem) in a cold-active Vibrio AP. Subsequently, we defined a methodology to quantify promiscuous activities in a wide range of proteins. Here, we assemble a module which encapsulates the multifarious motifs used by protease families listed in the MEROPS database. Since APs and proteases are an integral component of outer membrane vesicles (OMV), we sought to query other OMV proteins, like phospholipase C (PLC), using this search module. Our analysis indicated that phosphoinositide-specific PLC from Bacillus cereus is a serine protease. This was validated by protease assays, mass spectrometry and by inhibition of the native phospholipase activity of PI-PLC by the well-known serine protease inhibitor AEBSF (IC50 = 0.018 mM). Edman degradation analysis linked the specificity of the protease activity to a proline in the amino terminal, suggesting that the PI-PLC is a prolyl peptidase. Thus, we propose a computational method of extending protein families based on the spatial and electrostatic congruence of active site residues.

Functional morphology of amplexus (clasping) in spinicaudatan clam shrimps (Crustacea, Branchiopoda) and its evolution in bivalved branchiopods: A video-based analysis.

PubMed

Sigvardt, Zandra M S; Rogers, D Christopher; Olesen, Jørgen

2017-04-01

Male clam shrimps (Crustacea: Branchiopoda: Laevicaudata, Spinicaudata, and Cyclestherida) have their first one or two trunk limb pairs modified as "claspers," which are used to hold the female during mating and mate guarding. Clasper morphology has traditionally been important for clam shrimp taxonomy and classification, but little is known about how the males actually use the claspers during amplexus (clasping). Homologies of the various clasper parts ("movable finger," "large palp," "palm," "gripping area," and "small palp") have long been discussed between the three clam shrimp taxa, and studies have shown that only some structures are homologous while others are convergent ("partial homology"). We studied the clasper functionality in four spinicaudatan species using video recordings and scanning electron microscopy, and compared our results with other clam shrimp groups. General mating behavior and carapace morphology was also studied. Generally, spinicaudatan and laevicaudatan claspers function similarly despite some parts being nonhomologous. We mapped clasper morphology and functionality aspects on a branchiopod phylogeny. We suggest that the claspers of the three groups were adapted from an original, simpler clasper, each for a "stronger" grip on the female's carapace margin: 1) Spinicaudata have two clasper pairs bearing an elongated apical club/gripping area with one setal type; 2); Cyclestherida have one clasper pair with clusters of molariform setae on the gripping area and at the movable finger apex; and 3) Laevicaudata have one clasper pair, but have incorporated an additional limb portion into the clasper palm and bear a diverse set of setae. J. Morphol. 278:523-546, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

Gibberellin DELLA signaling targets the retromer complex to redirect protein trafficking to the plasma membrane

PubMed Central

Salanenka, Yuliya; Verstraeten, Inge; Löfke, Christian; Tabata, Kaori; Naramoto, Satoshi; Glanc, Matouš; Friml, Jiří

2018-01-01

The plant hormone gibberellic acid (GA) is a crucial regulator of growth and development. The main paradigm of GA signaling puts forward transcriptional regulation via the degradation of DELLA transcriptional repressors. GA has also been shown to regulate tropic responses by modulation of the plasma membrane incidence of PIN auxin transporters by an unclear mechanism. Here we uncovered the cellular and molecular mechanisms by which GA redirects protein trafficking and thus regulates cell surface functionality. Photoconvertible reporters revealed that GA balances the protein traffic between the vacuole degradation route and recycling back to the cell surface. Low GA levels promote vacuolar delivery and degradation of multiple cargos, including PIN proteins, whereas high GA levels promote their recycling to the plasma membrane. This GA effect requires components of the retromer complex, such as Sorting Nexin 1 (SNX1) and its interacting, microtubule (MT)-associated protein, the Cytoplasmic Linker-Associated Protein (CLASP1). Accordingly, GA regulates the subcellular distribution of SNX1 and CLASP1, and the intact MT cytoskeleton is essential for the GA effect on trafficking. This GA cellular action occurs through DELLA proteins that regulate the MT and retromer presumably via their interaction partners Prefoldins (PFDs). Our study identified a branching of the GA signaling pathway at the level of DELLA proteins, which, in parallel to regulating transcription, also target by a nontranscriptional mechanism the retromer complex acting at the intersection of the degradation and recycling trafficking routes. By this mechanism, GA can redirect receptors and transporters to the cell surface, thus coregulating multiple processes, including PIN-dependent auxin fluxes during tropic responses. PMID:29463731

Is there a relationship between genetic factors and the incidence and severity of H1N1 in Kosova?: A preliminary investigation and pointers for further research.

PubMed

Dreshaj, Shemsedin; Alija, Avdulla J; Schlagenhauf, Patricia; Doda, Teuta; Geca, Njomeza; Bajraktari, Ismet; Bresgen, Nikolaus; Eckl, Peter M

Host genetic factors may impact susceptibility to infection. A small number of studies have investigated the association between factors such as ABO blood groups and selected phenotypes on the incidence and severity of H1N1 infections with inconclusive results. Using data from the Clinic of Infectious Diseases - University Clinical Centre Prishtina and based on the examination of 125 patients hospitalized with H1N1 in the period 2009-2014, the frequency of blood groups from ABO and Rhesus (Rh) systems as phenotypical markers were evaluated. In addition, other phenotypes such as ear lobe free/ear lobe attached, normal chin/cleft chin, tongue roller/non roller, hand clasping right thumb over/hand clasping left thumb over, right-handed/left-handed, dark eyes/light eyes were also analyzed. The data obtained from the 125 hospitalized patients were compared with the data from the Kosovar population (n = 2000) as a reference group. A total of 303 patients with H1N1 were hospitalized in the period 2009-2015. Blood group and phenotype data available from 125 hospitalized H1N1 patients showed significant differences in the frequencies of the blood groups from Rh system as well as in two (out of six) phenotypes of the selected morphological traits compared to reference groups. The findings from this preliminary study indicate that these Rh system and phenotype differences may be linked to H1N1 susceptibility and may guide identification of risk groups and populations. Copyright © 2017 Elsevier Ltd. All rights reserved.

Ontogeny of a social custom in wild chimpanzees: age changes in grooming hand-clasp at Mahale.

PubMed

Nakamura, Michio; Nishida, Toshisada

2013-02-01

Among cultural behaviors of chimpanzees, the developmental processes of complex skills involved in tool use are relatively well known. However, few studies have examined the ontogeny of social customs that do not require complex skills. Thus, in this study, we describe the developmental process of the grooming hand-clasp (GHC), one of the well-known social customs of chimpanzees at Mahale. We have collected 383 cases of GHC where at least one of the participants was 15 years old or younger during 1994-2007. First performances of GHC with the mother were observed at around 4-6 years old; the earliest observed age was 4 years and 4 months old. The first performances of GHC with nonrelated females were at around age 9 years, and those with adult males at around 11 years. However, some orphans engaged in GHC earlier than nonorphans. By gradually expanding GHC partners from the mother to other females and then to males, chimpanzees increased the number of GHC partners with age. Young males were observed to perform GHC with larger numbers of partners than were young females. GHC by young chimpanzees was shorter in duration than that among adults. Overall, the ontogeny of GHC showed several dissimilarities with that of tool use and was more an extension of the development of typical grooming behavior. For example, infants did not try to perform GHC initially; instead, mothers were more active in the earliest stages. These results suggest that not all socially learned cultural behaviors are acquired in the way of learning tool use. There may be various ways of learning behavioral patterns that are performed continuously in a group and that consequently comprise culture in chimpanzees. © 2012 Wiley Periodicals, Inc.

Nonrandom γ-TuNA-dependent spatial pattern of microtubule nucleation at the Golgi.

PubMed

Sanders, Anna A W M; Chang, Kevin; Zhu, Xiaodong; Thoppil, Roslin J; Holmes, William R; Kaverina, Irina

2017-11-07

Noncentrosomal microtubule (MT) nucleation at the Golgi generates MT network asymmetry in motile vertebrate cells. Investigating the Golgi-derived MT (GDMT) distribution, we find that MT asymmetry arises from nonrandom nucleation sites at the Golgi (hotspots). Using computational simulations, we propose two plausible mechanistic models of GDMT nucleation leading to this phenotype. In the "cooperativity" model, formation of a single GDMT promotes further nucleation at the same site. In the "heterogeneous Golgi" model, MT nucleation is dramatically up-regulated at discrete and sparse locations within the Golgi. While MT clustering in hotspots is equally well described by both models, simulating MT length distributions within the cooperativity model fits the data better. Investigating the molecular mechanism underlying hotspot formation, we have found that hotspots are significantly smaller than a Golgi subdomain positive for scaffolding protein AKAP450, which is thought to recruit GDMT nucleation factors. We have further probed potential roles of known GDMT-promoting molecules, including γ-TuRC-mediated nucleation activator (γ-TuNA) domain-containing proteins and MT stabilizer CLASPs. While both γ-TuNA inhibition and lack of CLASPs resulted in drastically decreased GDMT nucleation, computational modeling revealed that only γ-TuNA inhibition suppressed hotspot formation. We conclude that hotspots require γ-TuNA activity, which facilitates clustered GDMT nucleation at distinct Golgi sites. © 2017 Sanders et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

[Population genetics of the inhabitants of Northern European USSR. II. Blood group distribution and antropogenetic characteristics in 6 villages in Archangel Oblast].

PubMed

Revazov, A A; Pasekov, V P; Lukasheva, I D

1975-01-01

The paper deals with the distribution of genetic markers (systems ABO, MN, Rh (D), Hp, PTC) and a number of demographic (folding of arms, hand clasping, tongue rolling, right- and left-handedness, of the type of ear lobe, of the types of dermatoglyphic patterns) in the inhabitants of 6 villages in the Mezen District of the Archangelsk Region of the RSFSR (river Peosa basin). The data presented in this work were obtained in the course of examination of over 800 persons. Differences in the interpretation of the results of generally adopted methods of statistical analysis of samples from small populations are discussed. Among the systems analysed in one third of all the cases there was a statistically significant deviation from Hardy-Weinberg's ratios. For the MN blood groups and haptoglobins this was caused by the excess of heterozygotes. The test of Hardy--Weinberg's ratios at the level of two-loci phenotypes revealed no statistically significant deviations either in separate villages or in all the villages taken together. The analysis of heterogeneity with respect to markers inherited according to Mendel's law revealed statistically significant differences between villages in all the systems except haptoglobins. A considerable heterogeneity in the distribution of family names, the frequencies of some of them varying from village to village from 0 to 90%. Statistically significant differences between villages were shown for all the anthropogenetic characters except arm folding, hand clasping and right-left-handedness. Considering the uniformity of the environmental pressure in the region examined, the heterogeneity of the population studied is apparently associated with a random genetic differentiation (genetic drift) and, possibly, with the effect of the progenitor.

Sounding Rocket Instrument Development at UAHuntsville/NASA MSFC

NASA Technical Reports Server (NTRS)

Kobayashi, Ken; Cirtain, Jonathan; Winebarger, Amy; Savage, Sabrina; Golub, Leon; Korreck, Kelly; Kuzin, Sergei; Walsh, Robert; DeForest, Craig; DePontieu, Bart;

Measurements of the Magnetic Field of the Upper Chromosphere with Polarimetry

NASA Technical Reports Server (NTRS)

Rachmeler, Laurel; Mckenzie, David; Winebarger, Amy; Kobayashi, Ken; Ishikawa, Ryohko; Kubo, Masahito; Narukage, Noriyuki; Bueno, Trujillo, Javier; Auchere, Frederic

2017-01-01

A major remaining challenge for heliophysics is to decipher the magnetic structure of the chromosphere. The chromosphere is the critical interface between the Sun's photosphere and corona: it contains more mass than the entire interplanetary heliosphere, requires a heating rate that is larger than that of the corona, and mediates all the energy driving the solar wind, solar atmospheric heating and solar eruptions. While measurements of the magnetic field in the photosphere are routine, the chromosphere poses several extra challenges. The magnetically sensitive lines formed in the upper chromosphere are in the ultraviolet, so space-based observations are required. The lines are often formed over a range of heights, sampling different plasma which complicates the inversion process. These lines are sensitive to the magnetic field via polarized light that is created or modified through the Hanle and Zeeman effects. There are a few observations of these lines, and a significant challenge remains in extracting the magnetic field from the polarization measurements, as detailed model atmospheres with advanced radiative transfer physics are needed. Real progress is obtained by a simultaneous improvement in both the observational side and the modeling side. We present information on the CLASP (Chromospheric LAyer Spectro-Polarimeter) sounding rocket program, and future prospects for these types of measurements.

Methylmercury exposure for 14 days (short-term) produces behavioral and biochemical changes in mouse cerebellum, liver, and serum.

PubMed

Macedo-Júnior, Sérgio José; Luiz-Cerutti, Murilo; Nascimento, Denise B; Farina, Marcelo; Soares Santos, Adair Roberto; de Azevedo Maia, Alcíbia Helena

2017-01-01

Various studies on methylmercury (MeHg)-induced toxicity focused on the central nervous system (CNS) as a primary target. However, MeHg-mediated toxicity is related to metallic interaction with electrophilic groups, which are not solely restricted to the CNS, but these reactive groups are present ubiquitously in several systems/organs. The aim of this study was thus to examine MeHg-induced systemic toxicity in mice using a standardized neurotoxicology testing exposure model to measure cerebellar neurotoxicity by determining biochemical and behavioral parameters in the cerebellum. After 2 weeks exposure to MeHg (40 µg/ml; diluted in drinking water; ad libitum), adult male Swiss mice showed a marked motor impairment characteristic of cerebellar toxicity as noted in the following tests: rotarod, beam walking, pole, and hind limb clasping. MeHg treatment resulted in Hg deposition in the cerebellum as well as reduction in cerebellar weight, glutathione peroxidase (GPx) activity, and interleukin (IL)-6 levels. MeHg ingestion increased cerebellar glutathione reductase (GR) activity and brain-derived neurotrophic factor (BDNF) levels. In addition to cerebellar toxicity, MeHg treatment also elevated total and non-high density lipoprotein (non-HDL) cholesterol levels, as well as serum aspartate transaminase (AST) and alanine transaminase (ALT) enzymatic activities, systemic parameters. Increased liver weight and reduced serum urea levels were also noted in MeHg-exposed mice. Taken together, our findings demonstrated that a well-standardized exposure protocol to examine MeHg-induced neurotoxicity also produced systemic toxicity in mice, which was characterized by changes in markers of hepatic function as well as serum lipid homeostasis.

Silent Sentry

NASA Technical Reports Server (NTRS)

1980-01-01

NASA developed personal security system, commercialized by Sentry Products, Inc. enables resident to summon instant help in case of medical emergency or threatened violence. Its principal elements are a pen-shaped signaling device, "silent" because its ultrasonic alert signal is inaudible to the human ear, and a system of receivers interconnected with a constantly-monitored aster console. SCAN pen weighs only two ounces and is worn on necklace or attached by a clip to the user's clothing. The person in trouble simply presses a clasp, releasing a hammer inside the pen which strikes an aluminum bar. The impact causes the bar to resonate like a tuning fork and emit the ultrasonic signal, which is detected by the nearest receiver.

Flexibility and hardness of dental stainless steel wrought wires used in Thailand.

PubMed

Benjakul, P; Cheunarrom, C; Ongthiemsak, C

2001-03-01

Stainless steel wrought wires used as clasp arms for removable partial dentures in Thailand were compared with those used in some other countries (in the as-received condition) in terms of flexibility, Vickers microhardness and composition. The results showed that there were significant differences (P< or =0.05) among the wires. A Japanese stainless steel wire (SK) was obviously different from the others. It had the lowest proportional limit and microhardness, but its flexibility was almost the same. The chemical composition of each wire was not greatly different. The wires were about 18-20 wt% chromium and 8-9 wt% nickel, except for the SK wire, which had about 12 wt% nickel.

Comparison of Australian and US Cost-Benefit Approaches to MEPS

DOE Office of Scientific and Technical Information (OSTI.GOV)

McMahon, James E.

2004-03-12

The Australian Greenhouse Office contracted with the Collaborative Labeling and Appliance Standards Program (CLASP) for LBNL to compare US and Australian approaches to analyzing costs and benefits of minimum energy performance standards (MEPS). This report compares the approaches for three types of products: household refrigerators and freezers, small electric storage water heaters, and commercial/industrial air conditioners. This report presents the findings of similarities and differences between the approaches of the two countries and suggests changes to consider in the approach taken in Australia. The purpose of the Australian program is to reduce greenhouse gas emissions, while the US program ismore » intended to increase energy efficiency; each program is thus subject to specific constraints. The market and policy contexts are different, with the USA producing most of its own products and conducting pioneering engineering-economic studies to identify maximum energy efficiency levels that are technologically feasible and economically justified. In contrast, Australia imports a large share of its products and adopts MEPS already in place elsewhere. With these differences in circumstances, Australia's analysis approach could be expected to have less analytical detail and still result in MEPS levels that are appropriate for their policy and market context. In practice, the analysis required to meet these different objectives is quite similar. To date, Australia's cost-benefit analysis has served the goals and philosophies of the program well and been highly effective in successfully identifying MEPS that are significantly reducing greenhouse gas emissions while providing economic benefits to consumers. In some cases, however, the experience of the USA--using more extensive data sets and more detailed analysis--suggests possible improvements to Australia's cost-benefit analysis. The principal findings of the comparison are: (1) The Technology and Market Assessments are similar; no changes are recommended. (2) The Australian approach to determining the relationship of price to energy efficiency is based on current market, while the US approach uses prospective estimates. Both approaches may benefit from increased retrospective analysis of impacts of MEPS on appliance and equipment prices. Under some circumstances, Australia may wish to consider analyzing two separate components leading to price impacts: (a) changes in manufacturing costs and (b) markups used to convert from manufacturing costs to consumer price. (3) The Life-Cycle Cost methods are similar, but the USA has statistical surveys that permit a more detailed analysis. Australia uses average values, while the US uses full distributions. If data and resources permit, Australia may benefit from greater depth here as well. If implemented, the changes will provide more information about the benefits and costs of the program, in particular identifying who benefits and who bears net costs so that programs can be designed to offset unintended negative consequences, and may assist the government in convincing affected parties of the justification for some MEPS. However, without a detailed and statistically representative national survey, such an approach may not be practical for Australia at this time. (4) The National Benefits and Costs methods are similar prospective estimates of shipments, costs and energy savings, as well as greenhouse gas emissions. Additional sensitivity studies could further illustrate the ranges in these estimates. Consideration of lower discount rates could lead to more stringent MEPS in some cases. (5) Both the Australian and US analyses of impacts on industry, competition, and trade ultimately depend upon sufficient consultation with industry experts. While the Australian analysis of financial impacts on manufacturers is less detailed than that of the US, the Australian treatment of impacts on market shares imported from different regions of the world is more detailed. No change is recommended. Implementing these changes would increase the depth of analysis, require additional data collection and analysis, and incur associated costs and time. The recommended changes are likely to have incremental rather than dramatic impacts on the substance and implications of the analysis as currently conducted.« less

Polarizers tuned at key far-UV spectral lines for space instrumentation

NASA Astrophysics Data System (ADS)

Larruquert, Juan I.; Malvezzi, A. Marco; Rodríguez-de Marcos, Luis; Giglia, Angelo; Gutiérrez-Luna, Nuria; Espinosa-Yáñez, Lucía.; Honrado-Benítez, Carlos; Aznárez, José A.; Massone, Giuseppe; Capobianco, Gerardo; Fineschi, Silvano; Nannarone, Stefano

2017-05-01

Polarimetry is a valuable technique to help us understand the role played by the magnetic field of the coronal plasma in the energy transfer processes from the inner parts of the Sun to the outer space. Polarimetry in the far ultraviolet (FUV: 100-200 nm), which must be performed from space due to absorption in terrestrial atmosphere, supplies fundamental data of processes that are governed by the Doppler and Hanle effects on resonantly scattered line-emission. To observe these processes there are various key spectral lines in the FUV, from which H I Lyman α (121.6 nm) is the strongest one. Hence some solar physics missions that have been proposed or are under development plan to perform polarimetry at 121.6 nm, like the suborbital missions CLASP I (2015) and CLASP II (2018), and the proposed solar missions SolmeX and COMPASS and stellar mission Arago. Therefore, the development of efficient FUV linear polarizers may benefit these and other possible future missions. C IV (155 nm) and Mg II (280 nm) are other spectral lines relevant for studies of solar and stellar magnetized atmospheres. High performance polarizers can be obtained with optimized coatings. Interference coatings can tune polarizers at the spectral line(s) of interest for solar and stellar physics. Polarizing beamsplitters consist in polarizers that separate one polarization component by reflection and the other by transmission, which enables observing the two polarization components simultaneously with a single polarizer. They involve the benefit of a higher efficiency in collection of polarization data due to the use of a single polarizer for the two polarization components and they may also facilitate a simplified design for a space polarimeter. We present results on polarizing beamsplitters tuned either at 121.6 nm or at the pair of 155 and 280 nm spectral lines.

A unique mating strategy without physical contact during fertilization in Bombay Night Frogs (Nyctibatrachus humayuni) with the description of a new form of amplexus and female call.

PubMed

Willaert, Bert; Suyesh, Robin; Garg, Sonali; Giri, Varad B; Bee, Mark A; Biju, S D

2016-01-01

Anurans show the highest diversity in reproductive modes of all vertebrate taxa, with a variety of associated breeding behaviours. One striking feature of anuran reproduction is amplexus. During this process, in which the male clasps the female, both individuals' cloacae are juxtaposed to ensure successful external fertilization. Several types of amplexus have evolved with the diversification of anurans, and secondary loss of amplexus has been reported in a few distantly related taxa. Within Nyctibatrachus, a genus endemic to the Western Ghats of India, normal axillary amplexus, a complete loss of amplexus, and intermediate forms of amplexus have all been suggested to occur, but many species remain unstudied. Here, we describe the reproductive behaviour of N. humayuni, including a new type of amplexus. The dorsal straddle, here defined as a loose form of contact in which the male sits on the dorsum of the female prior to oviposition but without clasping her, is previously unreported for anurans. When compared to known amplexus types, it most closely resembles the form of amplexus observed in Mantellinae. Furthermore, we prove that, opposed to the situation in most anurans, male semen release happens before egg deposition. We hypothesize that the male ejaculates on the female's dorsum and that sperm subsequently runs from her back and hind legs before fertilizing the eggs. A second feature characterizing anuran breeding is the advertisement call, mostly produced solely by males. Despite recent descriptions of several new Nyctibatrachus species, few studies have explored their vocal repertoire. We describe both the male advertisement call and a female call for N. humayuni. The presence of a female call has not been reported within Nyctibatrachidae, and has been reported in less than 0.5% of anuran species. Altogether, our results highlight a striking diversity and several unique aspects of Nyctibatrachus breeding behaviour.

Motor impairments, striatal degeneration, and altered dopamine-glutamate interplay in mice lacking PSD-95.

PubMed

Zhang, Jingping; Saur, Taixiang; Duke, Angela N; Grant, Seth G N; Platt, Donna M; Rowlett, James K; Isacson, Ole; Yao, Wei-Dong

2014-01-01

Excessive activation of the N-methyl-d-aspartate (NMDA) receptor and the neurotransmitter dopamine (DA) mediate neurotoxicity and neurodegeneration under many neurological conditions, including Huntington's disease (HD), an autosomal dominant neurodegenerative disease characterized by the preferential loss of medium spiny projection neurons (MSNs) in the striatum. PSD-95 is a major scaffolding protein in the postsynaptic density (PSD) of dendritic spines, where a classical role for PSD-95 is to stabilize glutamate receptors at sites of synaptic transmission. Our recent studies indicate that PSD-95 also interacts with the D1 DA receptor localized in spines and negatively regulates spine D1 signaling. Moreover, PSD-95 forms ternary protein complexes with D1 and NMDA receptors, and plays a role in limiting the reciprocal potentiation between both receptors from being escalated. These studies suggest a neuroprotective role for PSD-95. Here we show that mice lacking PSD-95, resulting from genetic deletion of the GK domain of PSD-95 (PSD-95-ΔGK mice), sporadically develop progressive neurological impairments characterized by hypolocomotion, limb clasping, and loss of DARPP-32-positive MSNs. Electrophysiological experiments indicated that NMDA receptors in mutant MSNs were overactive, suggested by larger, NMDA receptor-mediated miniature excitatory postsynaptic currents (EPSCs) and higher ratios of NMDA- to AMPA-mediated corticostriatal synaptic transmission. In addition, NMDA receptor currents in mutant cortical neurons were more sensitive to potentiation by the D1 receptor agonist SKF81297. Finally, repeated administration of the psychostimulant cocaine at a dose regimen not producing overt toxicity-related phenotypes in normal mice reliably converted asymptomatic mutant mice to clasping symptomatic mice. These results support the hypothesis that deletion of PSD-95 in mutant mice produces concomitant overactivation of both D1 and NMDA receptors that makes neurons more susceptible to NMDA excitotoxicity, causing neuronal damage and neurological impairments. Understanding PSD-95-dependent neuroprotective mechanisms may help elucidate processes underlying neurodegeneration in HD and other neurological disorders.

Research, practice, and policy partnerships in pan-Canadian coalitions for cancer and chronic disease prevention.

PubMed

Manafò, Elizabeth; Petermann, Lisa; Lobb, Rebecca; Keen, Deb; Kerner, Jon

2011-01-01

To describe the development stages of the Coalitions Linking Action and Science for Prevention (CLASP) initiative of the Canadian Partnership Against Cancer to support research, practice, and policy coalitions focused on cancer and chronic disease prevention in Canada. Coalitions Linking Action and Science for Prevention was implemented in 3 stages. This article describes Stage 1 that consisted of an online concept-mapping consultation process, 3 topic specific networking and consultation workshops, and 3 context-specific networking, coalition development, and planning meetings. These were all completed using a participatory engagement approach to encourage knowledge exchange across jurisdictions and sectors in Canada. Toronto, Ontario; Calgary, Alberta; Montreal, Québec; and Ottawa, Ontario. More than 500 researchers, practitioners, and policy specialists were invited to take part in the first stage activities. (1) Participant-identified high-priority opportunities for strategic collaboration; (2) Cross-jurisdictional and cross-sector representation; and (3) Participant feedback on the CLASP processes and activities. Participants from Stage 1 activities were distributed across all provinces/territories; 3 jurisdictional levels; and research, practice, and policy sectors. Ninety priority opportunities for strategic collaboration were identified across all 3 workshops. Participants provided detailed feedback about transparency of the RFP (Request for Proposals) application process, support needed to level the playing field for potential applicants, and valuable suggestions for the adjudication process. Coalitions Linking Action and Science for Prevention engaged hundreds of research, practice, and policy experts across Canada focusing social-behavioral, clinical, and environmental and occupational opportunities for cancer and chronic disease prevention. Given the extent of expert and jurisdictional engagement, the substantial Partnership investment in a participatory engagement approach to RFP development and potential applicant response suggests that efforts to link cancer and chronic disease prevention efforts across jurisdictions and through research, practice, and policy collaboration may require this type of a priori investment in networking, communication, coordination, and collaboration.

A unique mating strategy without physical contact during fertilization in Bombay Night Frogs (Nyctibatrachus humayuni) with the description of a new form of amplexus and female call

PubMed Central

Suyesh, Robin; Garg, Sonali; Giri, Varad B.; Bee, Mark A.

2016-01-01

Anurans show the highest diversity in reproductive modes of all vertebrate taxa, with a variety of associated breeding behaviours. One striking feature of anuran reproduction is amplexus. During this process, in which the male clasps the female, both individuals’ cloacae are juxtaposed to ensure successful external fertilization. Several types of amplexus have evolved with the diversification of anurans, and secondary loss of amplexus has been reported in a few distantly related taxa. Within Nyctibatrachus, a genus endemic to the Western Ghats of India, normal axillary amplexus, a complete loss of amplexus, and intermediate forms of amplexus have all been suggested to occur, but many species remain unstudied. Here, we describe the reproductive behaviour of N. humayuni, including a new type of amplexus. The dorsal straddle, here defined as a loose form of contact in which the male sits on the dorsum of the female prior to oviposition but without clasping her, is previously unreported for anurans. When compared to known amplexus types, it most closely resembles the form of amplexus observed in Mantellinae. Furthermore, we prove that, opposed to the situation in most anurans, male semen release happens before egg deposition. We hypothesize that the male ejaculates on the female’s dorsum and that sperm subsequently runs from her back and hind legs before fertilizing the eggs. A second feature characterizing anuran breeding is the advertisement call, mostly produced solely by males. Despite recent descriptions of several new Nyctibatrachus species, few studies have explored their vocal repertoire. We describe both the male advertisement call and a female call for N. humayuni. The presence of a female call has not been reported within Nyctibatrachidae, and has been reported in less than 0.5% of anuran species. Altogether, our results highlight a striking diversity and several unique aspects of Nyctibatrachus breeding behaviour. PMID:27326376

[Computer aided design and rapid manufacturing of removable partial denture frameworks].

PubMed

Han, Jing; Lü, Pei-jun; Wang, Yong

2010-08-01

To introduce a method of digital modeling and fabricating removable partial denture (RPD) frameworks using self-developed software for RPD design and rapid manufacturing system. The three-dimensional data of two partially dentate dental casts were obtained using a three-dimensional crossing section scanner. Self-developed software package for RPD design was used to decide the path of insertion and to design different components of RPD frameworks. The components included occlusal rest, clasp, lingual bar, polymeric retention framework and maxillary major connector. The design procedure for the components was as following: first, determine the outline of the component. Second, build the tissue surface of the component using the scanned data within the outline. Third, preset cross section was used to produce the polished surface. Finally, different RPD components were modeled respectively and connected by minor connectors to form an integrated RPD framework. The finished data were imported into a self-developed selective laser melting (SLM) machine and metal frameworks were fabricated directly. RPD frameworks for the two scanned dental casts were modeled with this self-developed program and metal RPD frameworks were successfully fabricated using SLM method. The finished metal frameworks fit well on the plaster models. The self-developed computer aided design and computer aided manufacture (CAD-CAM) system for RPD design and fabrication has completely independent intellectual property rights. It provides a new method of manufacturing metal RPD frameworks.

Expedition 17 Pre-launch Images from Kazakhstan

NASA Image and Video Library

2008-04-07

JSC2008-E-032248 (7 April 2008) --- At their crew quarters in Baikonur, Kazakhstan, Expedition 17 Commander Sergei Volkov (center), Flight Engineer Oleg Kononenko (right) and South Korean spaceflight participant So-yeon Yi clasp hands for photographers on April 7, 2008, the eve of their launch to the International Space Station. Volkov, Kononenko and Yi are scheduled to launch to the station on the Soyuz TMA-12 spacecraft from the Baikonur Cosmodrome on April 8 and arrive at the ISS on April 10 to begin what will be six months in space for Volkov and Kononenko. Yi will be in space nine days on the complex, returning to Earth with two of the Expedition 16 crewmembers currently on the station. Photo Credit: NASA /Victor Zelentsov

Expedition Three crew clasp hands for photo at pad

NASA Technical Reports Server (NTRS)

2001-01-01

KENNEDY SPACE CENTER, Fla. -- The Expedition Three crew join hands for a photo on Launch Pad 39A. From left are cosmonaut Vladimir Nikolaevich Dezhurov, Commander Frank Culbertson and cosmonaut Mikhail Tyurin. The STS-105 and Expedition Three crews are at Kennedy Space Center participating in a Terminal Countdown Demonstration Test, a dress rehearsal for launch. The activities include emergency egress training, a simulated launch countdown and familiarization with the payload. Mission STS-105 will be transporting the Expedition Three crew, several payloads and scientific experiments to the International Space Station aboard Space Shuttle Discovery. The Expedition Two crew members currently on the Station will return to Earth on Discovery. The mission is scheduled to launch no earlier than Aug. 9, 2001.

STS-102 MS Helms, Usachev and Voss pose on the FSS at Launch Pad 39B during TCDT

NASA Technical Reports Server (NTRS)

2001-01-01

KENNEDY SPACE CENTER, Fla. -- STS-102 Mission Specialists Susan Helms, Yury Usachev and James Voss clasp hands showing their unity as the Expedition Two crew who will be replacing Expedition One on the International Space Station. Behind them can be seen the tops of the solid rocket booster and external tank on Space Shuttle Discovery. The STS-102 crew is at KSC for Terminal Countdown Demonstration Test activities, which include the emergency training and a simulated launch countdown. STS-102 is the eighth construction flight to the Space Station, with Discovery carrying the Multi-Purpose Logistics Module Leonardo. Expedition One will return to Earth with Discovery. Launch on mission STS-102 is scheduled for March 8.

Observational Consequences of Coronal Heating Mechanisms

NASA Technical Reports Server (NTRS)

Winebarger, Amy R.; Cirtain, Jonathan C.; Golub, Leon; Kobayashi, Ken

2014-01-01

The coronal heating problem remains unsolved today, 80 years after its discovery, despite 50 years of suborbital and orbital coronal observatories. Tens of theoretical coronal heating mechanisms have been suggested, but only a few have been able to be ruled out. In this talk, we will explore the reasons for the slow progress and discuss the measurements that will be needed for potential breakthrough, including imaging the solar corona at small spatial scales, measuring the chromospheric magnetic fields, and detecting the presence of high temperature, low emission measure plasma. We will discuss three sounding rocket instruments developed to make these measurements: the High resolution Resolution Coronal Imager (Hi-C), the Chromospheric Lyman-Alpha Spectropolarimeter (CLASP), and the Marshall Grazing Incidence X-ray Spectrometer (MaGIXS).

New Instruments to Isolate the Coronal Heating Mechanism

NASA Technical Reports Server (NTRS)

Winebarger, Amy

2014-01-01

The coronal heating problem remains unsolved today, 80 years after its discovery, despite 50 years of suborbital and orbital coronal observatories. Tens of theoretical coronal heating mechanisms have been suggested, but only a few have been able to be ruled out. In this talk, we will explore the reasons for the slow progress and discuss the measurements that will be needed for potential breakthrough, including imaging the solar corona at small spatial scales, measuring the chromospheric magnetic fields, and detecting the presence of high temperature, low-emission measure plasma. We will discuss three sounding rocket instruments developed to make these measurements: the High-resolution Resolution Coronal Imager (Hi-C), the Chromospheric Lyman-Alpha Spectropolarimeter (CLASP), and the Marshall Grazing Incidence X-ray Spectrometer (MaGIXS).

The Windowed Removable Partial Denture: A Treatment Option for Patients with Lone-Standing Teeth.

PubMed

Jum'ah, Ahmad A; Haite, Terence; Nattress, Brian

2015-03-01

The decision as to whether to retain or extract a single remaining natural tooth prior to the provision of dentures can be a difficult one. If the tooth is left in situ, the development of an adequate peripheral seal around the denture is not possible thereby compromising the appliance' retention. If the tooth is extracted the possibility of gaining direct retention with the use of clasps or attachments is lost. This paper aims to illustrate the use of windowed removable partial denture design and review the literature relevant to this area. The use of such a design can enhance the retention of the appliance by encircling the lone standing tooth/teeth utilising an elastomeric permanent soft lining material.

Dynamics in the Chromosphere Imaged at Four Second Cadence

NASA Astrophysics Data System (ADS)

Schmit, D.; De Pontieu, B.

2017-12-01

In this work we present analysis of rapid intensity fluctuations that are observed in the chromosphere and transition region using the slit-jaw datasets of IRIS and CLASP. While chromospheric oscillations have been a topic of interest for 30 years, the instrumentation to image those dynamics at high-cadence has only recently been developed. We use filtergraph data from 1215A, 2800A, and 1400A to examine the occurrence rate and morphology of rapid intensity fluctuations in different magnetic environments. There are indications of rapidly propagating disturbances with phase speeds greater than 100 km/s in all passbands although the morphology of the features differs significantly between passbands. The relationship between intensity fluctuations, spicules, and waves is discussed.

Dominating clasp of the financial sector revealed by partial correlation analysis of the stock market.

PubMed

Kenett, Dror Y; Tumminello, Michele; Madi, Asaf; Gur-Gershgoren, Gitit; Mantegna, Rosario N; Ben-Jacob, Eshel

2010-12-20

What are the dominant stocks which drive the correlations present among stocks traded in a stock market? Can a correlation analysis provide an answer to this question? In the past, correlation based networks have been proposed as a tool to uncover the underlying backbone of the market. Correlation based networks represent the stocks and their relationships, which are then investigated using different network theory methodologies. Here we introduce a new concept to tackle the above question--the partial correlation network. Partial correlation is a measure of how the correlation between two variables, e.g., stock returns, is affected by a third variable. By using it we define a proxy of stock influence, which is then used to construct partial correlation networks. The empirical part of this study is performed on a specific financial system, namely the set of 300 highly capitalized stocks traded at the New York Stock Exchange, in the time period 2001-2003. By constructing the partial correlation network, unlike the case of standard correlation based networks, we find that stocks belonging to the financial sector and, in particular, to the investment services sub-sector, are the most influential stocks affecting the correlation profile of the system. Using a moving window analysis, we find that the strong influence of the financial stocks is conserved across time for the investigated trading period. Our findings shed a new light on the underlying mechanisms and driving forces controlling the correlation profile observed in a financial market.

Building the capacity of health authorities to influence land use and transportation planning: Lessons learned from the Healthy Canada by Design CLASP Project in British Columbia.

PubMed

Miro, Alice; Perrotta, Kim; Evans, Heather; Kishchuk, Natalie A; Gram, Claire; Stanwick, Richard S; Swinkels, Helena M

2014-08-06

The main objective of the Healthy Canada by Design CLASP Initiative in British Columbia (BC) was to develop, implement and evaluate a capacity-building project for health authorities. The desired outcomes of the project were as follows: 1) increased capacity of the participating health authorities to productively engage in land use and transportation planning processes; 2) new and sustained relationships or collaborations among the participating health authorities and among health authorities, local governments and other built environment stakeholders; and 3) indication of health authority influence and/or application of health evidence and tools in land use and transportation plans and policies. This project was designed to enhance the capacity of three regional health authorities, namely Fraser Health, Island Health and Vancouver Coastal Health, and their staff. These were considered the project's participants. The BC regions served by the three health authorities cover the urban, suburban and rural spectrum across relatively large and diverse geographic areas. The populations have broad ranges in socio-economic status, demographic profiles and cultural and political backgrounds. The Initiative provided the three health authorities with a consultant who had several years of experience working on land use and transportation planning. The consultant conducted situational assessments to understand the baseline knowledge and skill gaps, assets and objectives for built environment work for each of the participating health authorities. On the basis of this information, the consultant developed customized capacity-building work plans for each of the health authorities and assisted them with implementation. Capacity-building activities were as follows: researching health and built environment strategies, policies and evidence; transferring health evidence and promising policies and practices from other jurisdictions to local planning contexts; providing training and support with regard to health and the built environment to health authority staff; bringing together public health staff with local planners for networking; and participating in land use planning processes. The project helped to expand the capacity of participating health authorities to influence land use and transportation planning decisions by increasing the content and process expertise of public health staff. The project informed structural changes within health authorities, such as staffing reallocations to advance built environment work after the project. Health authorities also forged new relationships within and across sectors, which facilitated knowledge exchange and access of the public health sector to opportunities to influence built environment decisions. By the end of the project, there was emerging evidence of a health presence in land use policy documents. The project helped to prioritize, accelerate and formalize the participating health authorities' involvement in land use and transportation planning processes. In the long term, this is expected to lead to health policies and programs that consider the built environment, and to built environment policies and practices that integrate population health goals, thereby reducing the risk of chronic diseases.

Cpd-1 Null Mice Display a Subtle Neurological Phenotype

PubMed Central

Kular, Rupinder K.; Gogliotti, Rocky G.; Opal, Puneet

2010-01-01

Background CPD1 (also known as ANP32-E) belongs to a family of evolutionarily conserved acidic proteins with leucine rich repeats implicated in a variety of cellular processes regulating gene expression, vesicular trafficking, intracellular signaling and apoptosis. Because of its spatiotemporal expression pattern, CPD1 has been proposed to play an important role in brain morphogenesis and synaptic development. Methodology/Principal Findings We have generated CPD1 knock-out mice that we have subsequently characterized. These mice are viable and fertile. However, they display a subtle neurological clasping phenotype and mild motor deficits. Conclusions/Significance CPD1 is not essential for normal development; however, it appears to play a role in the regulation of fine motor functions. The minimal phenotype suggests compensatory biological mechanisms. PMID:20844742

Strategy for Realizing High-Precision VUV Spectro-Polarimeter

NASA Astrophysics Data System (ADS)

Ishikawa, R.; Narukage, N.; Kubo, M.; Ishikawa, S.; Kano, R.; Tsuneta, S.

2014-12-01

Spectro-polarimetric observations in the vacuum ultraviolet (VUV) range are currently the only means to measure magnetic fields in the upper chromosphere and transition region of the solar atmosphere. The Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP) aims to measure linear polarization at the hydrogen Lyman- α line (121.6 nm). This measurement requires a polarization sensitivity better than 0.1 %, which is unprecedented in the VUV range. We here present a strategy with which to realize such high-precision spectro-polarimetry. This involves the optimization of instrument design, testing of optical components, extensive analyses of polarization errors, polarization calibration of the instrument, and calibration with onboard data. We expect that this strategy will aid the development of other advanced high-precision polarimeters in the UV as well as in other wavelength ranges.

RIDE vs. CLASP Comparison and Evaluation: Models and Parameters

DTIC Science & Technology

2007-04-01

the model is declared "No Decision," indicating that neither QLRM nor LLRM provides a satisfactory fit. If p-value ( i 2j ) > p-value ( flj ), then our...evaluated at A = D = loo tD (7) UA/D(70,40) = 37.35 (8) UA/D(70,100) = 22.93 (9) OUA/D = 0 when evaluated at A = 70, D = 65.7 aD Note the number of...M U) U) C)U)f-~H W 0 U) co CQ CU)QC) W W 0 O40U) El)U tq D O U) U) E U) Z 04 X L X 4j c)c: o n n , f)cj" D ,m u)o mm o:zz .o tD o U) Uti)U) ’-4 r-4

Precision VUV Spectro-Polarimetry for Solar Chromospheric Magnetic Field Measurements

NASA Astrophysics Data System (ADS)

Ishikawa, R.; Bando, T.; Hara, H.; Ishikawa, S.; Kano, R.; Kubo, M.; Katsukawa, Y.; Kobiki, T.; Narukage, N.; Suematsu, Y.; Tsuneta, S.; Aoki, K.; Miyagawa, K.; Ichimoto, K.; Kobayashi, K.; Auchère, F.; Clasp Team

2014-10-01

The Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP) is a VUV spectro-polarimeter optimized for measuring the linear polarization of the Lyman-α line (121.6 nm) to be launched in 2015 with NASA's sounding rocket (Ishikawa et al. 2011; Narukage et al. 2011; Kano et al. 2012; Kobayashi et al. 2012). With this experiment, we aim to (1) observe the scattering polarization in the Lyman-α line, (2) detect the Hanle effect, and (3) assess the magnetic fields in the upper chromosphere and transition region for the first time. The polarization measurement error consists of scale error δ a (error in amplitude of linear polarization), azimuth error Δφ (error in the direction of linear polarization), and spurious polarization ɛ (false linear polarization signals). The error ɛ should be suppressed below 0.1% in the Lyman-α core (121.567 nm ±0.02 nm), and 0.5% in the Lyman-α wing (121.567 nm ±0.05 nm), based on our scientific requirements shown in Table 2 of Kubo et al. (2014). From scientific justification, we adopt Δ φ<2° and δ a<10% as the instrument requirements. The spectro-polarimeter features a continuously rotating MgF2 waveplate (Ishikawa et al. 2013), a dual-beam spectrograph with a spherical grating working also as a beam splitter, and two polarization analyzers (Bridou et al. 2011), which are mounted at 90 degree from each other to measure two orthogonal polarization simultaneously. For the optical layout of the CLASP instrument, see Figure 3 in Kubo et al. (2014). Considering the continuous rotation of the half-waveplate, the modulation efficiency is 0.64 both for Stokes Q and U. All the raw data are returned and demodulation (successive addition or subtraction of images) is done on the ground. We control the CLASP polarization performance in the following three steps. First, we evaluate the throughput and polarization properties of each optical component in the Lyman-α line, using the Ultraviolet Synchrotron ORbital Radiation Facility (UVSOR) at the Institute for Molecular Science. The second step is polarization calibration of the spectro-polarimeter after alignment. Since the spurious polarization caused by the axisymmetric telescope is estimated to be negligibly small because of the symmetry (Ishikawa et al. 2014), we do not perform end-to-end polarization calibration. As the final step, before the scientific observation near the limb, we make a short observation at the Sun center and verify the polarization sensitivity, because the scattering polarization is expected to be close to zero at the Sun center due to symmetric geometry. In order to clarify whether we will be able to achieve the required polarization sensitivity and accuracy via these steps, we exercise polarization error budget, by investigating all the possible causes and their magnitudes of polarization errors, all of which are not necessarily verified by the polarization calibration. Based on these error budgets, we conclude that a polarization sensitivity of 0.1% in the line core, δ a<10% and Δ φ<2° can be achieved combined with the polarization calibration of the spectro-polarimeter and the onboard calibration at the Sun center(refer to Ishikawa et al. 2014, for the detail). We are currently conducting verification tests of the flight components and development of the UV light source for the polarization calibration. From 2014 spring, we will begin the integration, alignment, and calibration. We will update the error budgets throughout the course of these tests.

Multimedia manuscript. Heller myotomy and intraluminal fundoplication: a NOTES technique.

PubMed

Perretta, Silvana; Dallemagne, Bernard; Allemann, Pierre; Alleman, Pierre; Marescaux, Jacques

2010-11-01

It is generally accepted that the most effective treatment of achalasia is a surgical myotomy. Nevertheless, if a myotomy alone is performed, reflux may occur in up to 30% of patients. The aim of this study was to explore a transoral incisionless stepwise approach to both esophageal Heller myotomy and fundoplication. The first step consisted of creating the esophageal myotomy. Under general anesthesia, with the pig supine, endoscopy was performed to assess the location of the esophagogastric junction (EGJ). The mucosa on the right posterolateral esophageal wall was cut with the needle-knife 15 cm above the lower esophageal sphincter (LES) and then dilated with blunt dissection to introduce the scope. A submucosal tunnel was created distally with CO(2) and blunt dissection. Once the gastroesophageal junction (GEJ) and the clasp fibers were identified, the muscular layer was cut. The scope was withdrawn into the lumen and the mucosal flap was sealed with endoscopic clips. The adequacy of the myotomy was evaluated using pre- and postoperative manometry and by comparing the EGJ distensibility before, during, and after the division of the esophageal muscular fibers using the functional lumen imaging probe, EndoFLIP®. The second step, consisted of building a transoral incisionless fundoplication 4 weeks postoperatively using the EsophyX™. Both Heller myotomy and endoscopic fundoplication were accomplished successfully with no injury to the esophageal mucosa. Postoperative manometry demonstrated a 50% loss in mean LES pressure (mean preoperative LES pressure = 22.2 mmHg; mean postoperative LES pressure = 10 mmHg, P < 0.005). The EndoFLIP® showed a preoperative minimal diameter of 6 mm with a cross-sectional area of 28 mm(2). Postoperatively, the junction was more compliant (minimal diameter = 15 mm; cross-sectional area = 177 mm(2)), with the main improvement in distensibility occurring when the clasps fibers were removed. A stepwise transoral incisionless approach to esophageal Heller myotomy and partial fundoplication is feasible and effective in the porcine model. A distensibility test such as the EndoFLIP® may provide better information on the opening and closing dynamics of the EGJ, rather than just relying on the sphincter tonic state as measured by manometry.

Brain Cholesterol Synthesis and Metabolism is Progressively Disturbed in the R6/1 Mouse Model of Huntington's Disease: A Targeted GC-MS/MS Sterol Analysis.

PubMed

Kreilaus, Fabian; Spiro, Adena S; Hannan, Anthony J; Garner, Brett; Jenner, Andrew M

2015-01-01

Cholesterol has essential functions in neurological processes that require tight regulation of synthesis and metabolism. Perturbed cholesterol homeostasis has been demonstrated in Huntington's disease, however the exact role of these changes in disease pathogenesis is not fully understood. This study aimed to comprehensively examine changes in cholesterol biosynthetic precursors, metabolites and oxidation products in the striatum and cortex of the R6/1 transgenic mouse model of Huntington's disease. We also aimed to characterise the progression of the physical phenotype in these mice. GC-MS/MS was used to quantify a broad range of sterols in the striatum and cortex of R6/1 and wild type mice at 6, 12, 20, 24 and 28 weeks of age. Motor dysfunction was assessed over 28 weeks using the RotaRod and the hind-paw clasping tests. 24(S)-Hydroxycholesterol and 27-hydroxycholesterol were the major cholesterol metabolites that significantly changed in R6/1 mice. These changes were specifically localised to the striatum and were detected at the end stages of the disease. Cholesterol synthetic precursors (lathosterol and lanosterol) were significantly reduced in the cortex and striatum by 6 weeks of age, prior to the onset of motor dysfunction, as well as the cognitive and affective abnormalities previously reported. Elevated levels of desmosterol, a substrate of delta(24)-sterol reductase (DHCR24), were also detected in R6/1 mice at the end time-point. Female R6/1 mice exhibited a milder weight loss and hind paw clasping phenotype compared to male R6/1 mice, however, no difference in the brain sterol profile was detected between sexes. Several steps in cholesterol biosynthetic and metabolic pathways are differentially altered in the R6/1 mouse brain as the disease progresses and this is most severe in the striatum. This provides further insights into early molecular mediators of HD onset and disease progression and identifies candidate molecular targets for novel therapeutic approaches.

Effects of a Sativex-Like Combination of Phytocannabinoids on Disease Progression in R6/2 Mice, an Experimental Model of Huntington’s Disease

PubMed Central

Valdeolivas, Sara; Sagredo, Onintza; Delgado, Mercedes; Pozo, Miguel A.; Fernández-Ruiz, Javier

2017-01-01

Several cannabinoids afforded neuroprotection in experimental models of Huntington’s disease (HD). We investigated whether a 1:1 combination of botanical extracts enriched in either ∆9-tetrahydrocannabinol (∆9-THC) or cannabidiol (CBD), which are the main constituents of the cannabis-based medicine Sativex®, is beneficial in R6/2 mice (a transgenic model of HD), as it was previously shown to have positive effects in neurotoxin-based models of HD. We recorded the progression of neurological deficits and the extent of striatal deterioration, using behavioral, in vivo imaging, and biochemical methods in R6/2 mice and their corresponding wild-type mice. The mice were daily treated, starting at 4 weeks after birth, with a Sativex-like combination of phytocannabinoids (equivalent to 3 mg/kg weight of pure CBD + ∆9-THC) or vehicle. R6/2 mice exhibited the characteristic deterioration in rotarod performance that initiated at 6 weeks and progressed up to 10 weeks, and elevated clasping behavior reflecting dystonia. Treatment with the Sativex-like combination of phytocannabinoids did not recover rotarod performance, but markedly attenuated clasping behavior. The in vivo positron emission tomography (PET) analysis of R6/2 animals at 10 weeks revealed a reduced metabolic activity in the basal ganglia, which was partially attenuated by treatment with the Sativex-like combination of phytocannabinoids. Proton nuclear magnetic resonance spectroscopy (H+-MRS) analysis of the ex vivo striatum of R6/2 mice at 12 weeks revealed changes in various prognostic markers reflecting events typically found in HD patients and animal models, such as energy failure, mitochondrial dysfunction, and excitotoxicity. Some of these changes (taurine/creatine, taurine/N-acetylaspartate, and N-acetylaspartate/choline ratios) were completely reversed by treatment with the Sativex-like combination of phytocannabinoids. A Sativex-like combination of phytocannabinoids administered to R6/2 mice at the onset of motor symptoms produced certain benefits on the progression of striatal deterioration in these mice, which supports the interest of this cannabinoid-based medicine for the treatment of disease progression in HD patients. PMID:28333097

Effects of a Sativex-Like Combination of Phytocannabinoids on Disease Progression in R6/2 Mice, an Experimental Model of Huntington's Disease.

PubMed

Valdeolivas, Sara; Sagredo, Onintza; Delgado, Mercedes; Pozo, Miguel A; Fernández-Ruiz, Javier

2017-03-23

Several cannabinoids afforded neuroprotection in experimental models of Huntington's disease (HD). We investigated whether a 1:1 combination of botanical extracts enriched in either ∆⁸-tetrahydrocannabinol (∆⁸-THC) or cannabidiol (CBD), which are the main constituents of the cannabis-based medicine Sativex ® , is beneficial in R6/2 mice (a transgenic model of HD), as it was previously shown to have positive effects in neurotoxin-based models of HD. We recorded the progression of neurological deficits and the extent of striatal deterioration, using behavioral, in vivo imaging, and biochemical methods in R6/2 mice and their corresponding wild-type mice. The mice were daily treated, starting at 4 weeks after birth, with a Sativex-like combination of phytocannabinoids (equivalent to 3 mg/kg weight of pure CBD + ∆⁸-THC) or vehicle. R6/2 mice exhibited the characteristic deterioration in rotarod performance that initiated at 6 weeks and progressed up to 10 weeks, and elevated clasping behavior reflecting dystonia. Treatment with the Sativex-like combination of phytocannabinoids did not recover rotarod performance, but markedly attenuated clasping behavior. The in vivo positron emission tomography (PET) analysis of R6/2 animals at 10 weeks revealed a reduced metabolic activity in the basal ganglia, which was partially attenuated by treatment with the Sativex-like combination of phytocannabinoids. Proton nuclear magnetic resonance spectroscopy (H⁺-MRS) analysis of the ex vivo striatum of R6/2 mice at 12 weeks revealed changes in various prognostic markers reflecting events typically found in HD patients and animal models, such as energy failure, mitochondrial dysfunction, and excitotoxicity. Some of these changes (taurine/creatine, taurine/ N -acetylaspartate, and N -acetylaspartate/choline ratios) were completely reversed by treatment with the Sativex-like combination of phytocannabinoids. A Sativex-like combination of phytocannabinoids administered to R6/2 mice at the onset of motor symptoms produced certain benefits on the progression of striatal deterioration in these mice, which supports the interest of this cannabinoid-based medicine for the treatment of disease progression in HD patients.

Occlusion of artificial teeth in partial dentures in the "chewing center"--first exploratory population-based evaluations.

PubMed

Kordass, B; Ruge, S; Quooss, A; Hugger, A; Mundt, T

2014-01-01

Occlusal performance is a substantial determinant of the quality of dental prosthetic restorations. In the follow-up (SHIP 1) to the Study of Health in Pomerania (SHIP), a representative population of 3300 subjects was studied in the first exploratory evaluation of the occlusion of artificial teeth in the chewing center (first molar region) of partial dentures. A digital analysis of interocclusal records of habitual intercuspation position (ICP) was performed using the Greifswald Digital Analyzing System (GEDAS), a software package that identifies contact points as transparent areas. 562 subjects (280 men aged 61.7 ± 11.9 years and 282 women aged 60.7 ± 10.7 years) had maxillary removable partial dentures (RPDs), and 619 (271 men aged 65.0 ± 11.5 years and 348 women aged 62.4 ± 10.6 years) had mandibular RPDs. Most RPDs were retained with either attachment retainers (11.7% maxilla, 11.7% mandible), cast clasps (38.4% maxilla, 40.7% mandible), telescopes with double crowns (15.7% maxilla, 19.1% mandible), or wrought wire clasps (16.4% maxilla, 8.2% mandible). Some had a combination of different retention elements. The mean number of artificial teeth was 7.8 ± 2.9 in the maxilla and 7.5 ± 3.0 in the mandible. Only the artificial teeth (first molars) in mandibular partial dentures showed differences in the frequency of occlusal contacts between groups (chi-square test). Of these, telescopic crown-retained RPDs had the highest frequency of occlusal contacts (74.4% at tooth 36 and 77.1% at tooth 46), and wrought wire-retained RPDs had the lowest (48.4% at tooth 36 and 45.2% at tooth 46). The results for RPDs with a free-end saddle were comparable and analogous; contact frequencies for those with an interdental saddle did not differ significantly. Notably, the overall frequency of occlusal contacts was greater for tooth 46 (62.9%) than for tooth 36. In conclusion, when replacing teeth in the chewing center, particularly in the mandible, telescopic crown-retained RPDs offer a distinct advantage in terms of occlusal contacts and thus provide better occlusal stability.

[Operative applications of occupational therapy].

PubMed

Saade, A

2010-01-01

Occupational therapy is the branch of rehabilitation whose main aim is to achieve maximum possible autonomy of the disabled person and the most complete integration into society, family and work. In subjects with motor disabilities following an occupational injury, the re-education programme includes a series of interventions aimed at progressive recovery of the ability to carry out work tasks compatible with the residual motor capacity of the worker. This article presents some examples related to the different stages making up the specific re-education programme: from the initial stages (with more purely kinesiotherapeutic techniques) directed at recovering movements and muscle strength, to the intermediate and final stages (more typically ergotherapeutic) directed first at the recovery of basic functions (clasping, pulling, pushing, lifting, lowering, carrying, etc.) and then, finally, retraining of work movements, with the introduction of compensatory methods and/or use of auxiliaries, when necessary.

The fatigue life of a cobalt-chromium alloy after laser welding.

PubMed

Al-Bayaa, Nabil Jalal Ahmad; Clark, Robert K F; Juszczyk, Andrzej S; Radford, David R

2011-03-01

The aim of this study was to investigate the fatigue life of laser welded joints in a commercially available cast cobalt-chromium alloy. Twenty rod shaped specimens (40 mm x 1.5 mm) were cast and sand blasted. Ten specimens were used as controls and the remaining ten were sectioned and repaired using a pulsed Nd: YAG laser welder. All specimens were subjected to fatigue testing (30N - 2Hz) in a controlled environment. A statistically significant difference in median fatigue life was found between as-cast and laser welded specimens (p < 0.001). Consequently, the technique may not be appropriate for repairing cobalt chromium clasps on removable partial dentures. Scanning electron microscopy indicated the presence of cracks, pores and constriction of the outer surface in the welded specimens despite 70% penetration of the weld.

Additional evidence of far transfer of scientific reasoning skills acquired in a CLASP reformed physics course

NASA Astrophysics Data System (ADS)

Potter, Wendell H.; Lynch, Robert B.

2013-01-01

The introductory physics course taken by biological science majors at UC Davis, Physics 7, was radically reformed 16 years ago in order to explicitly emphasize the development of scientific reasoning skills in all elements of the course. We have previously seen evidence of increased performance on the biological and physical science portions of the MCAT exam, in a rigorous systemic physiology course, and higher graduating GPAs for students who took Physics 7 rather than a traditionally taught introductory physics course. We report here on the increased performance by a group of biological-science majors in a general chemistry course who took the first quarter of Physics 7 prior to beginning the chemistry course sequence compared to a similar group who began taking physics after completing the first two quarters of general chemistry.

Agency elicits body-ownership: proprioceptive drift toward a synchronously acting external proxy.

PubMed

Asai, Tomohisa

2016-05-01

Awareness of our own bodies (sense of body-ownership) and actions (sense of agency) is fundamental for self-consciousness. In the rubber hand illusion, watching a rubber hand being stroked synchronously as one's own unseen hand is also stroked causes the observer to attribute the rubber hand to their own body. The findings of the series of experiments reported here suggest that body-ownership, measured using proprioceptive drift, is elicited by the external acting proxy that drives the sense of agency. While participants clasped and unclasped their left hand for 60 s, they focused on video feedback on a monitor in front of them. Proprioceptive drift was observed only under the conditions, including synchronized conditions, where the sense of agency for the acting proxy occurred, suggesting an essential interaction between body-ownership and agency.

Full body restraint system

NASA Technical Reports Server (NTRS)

Ryder, Susan (Inventor)

1990-01-01

A body restraint system (30) allows the user's body (10) to be in the zero gravity neutral posture. The system (30) includes a waist restraint (32) in the form of a curved, padded unit (34) containing a retractable belt (36) coiled on a spring loaded capstan (38) with a buckle (40) extending from front (42) of the unit (34). A second belt (44) is fastened around the user's waist (16). A clasp (46) is configured to engage the buckle (40). The waist restraint (32) is positioned near foot restraints (52). The foot restraints (52) have foot platforms (59) with pads (60) of a suitable two part attaching material, such as the fasteners available from Minnesota Mining and Manufacturing Company under the trademark Scotchmate Duallock. A mating pad (62) of the material is provided on soles (64) of cotton net shoes (66).

Eddy covariance measurements of sea spray particles over the Atlantic Ocean

NASA Astrophysics Data System (ADS)

Norris, S.; Brooks, I.; de Leeuw, G.; Smith, M. H.; Moeman, M.; Lingard, J.

2007-09-01

Most estimates of sea spray aerosol source functions have used indirect means to infer the rate of production as a function of wind speed. Only recently has the technology become available to make high frequency measurements of aerosol concentration suitable for direct eddy correlation determination of the particle flux. This was accomplished in this study by combining a newly developed fast aerosol particle counter with an ultrasonic anemometer which allowed for eddy covariance measurements of size-segregated particle fluxes. The aerosol instrument is the Compact Lightweight Aerosol Spectrometer Probe (CLASP) - capable of measuring 8-channel size spectra for mean radii between 0.15 and 0.35 μm at 10 Hz. The first successful measurements were made during the WASFAB (Waves, Air Sea Fluxes, Aerosol and Bubbles) field campaign in October 2005 in Duck (NC, USA). The method and results are presented and comparisons are made with recent sea spray source functions from the literature.

Mate-finding behaviour in Calanus marshallae Frost

PubMed Central

Tsuda, A.

1998-01-01

Mate-finding behaviour by Calanus marshallae Frost, 1974, was observed and video recorded in a 1 m diameter kreisel. Newly moulted females signal to males by depositing vertical pheromone trails many tens of centimetres long. Males search for trails along primarily horizontal trajectories. The orthogonality of signal trace and search trail trajectory maximizes the chance of intersection. Males often initiate a dance of rapid, tight turns upon encountering a pheromone trail, then waggle down it (chase swimming) to the signalling female. She jumps away after initial contact, and the male follows. Many successive approach, bump and jump sequences follow, with mating eventually ensuing. The actual copulatory clasp and spermatophore transfer were not observed, although a few instances of brief attachment and tandem swimming were seen. Male dances occur at times when chase swimming does not follow, and the function of dances is not yet known.

An endoparasitoid Cretaceous fly and the evolution of parasitoidism.

PubMed

Zhang, Qingqing; Zhang, Junfeng; Feng, Yitao; Zhang, Haichun; Wang, Bo

2016-02-01

Parasitoidism is a key innovation in insect evolution, and parasitoid insects, nowadays, play a significant role in structuring ecological communities. Despite their diversity and ecological impact, little is known about the early evolution and ecology of parasitoid insects, especially parasitoid true flies (Diptera). Here, we describe a bizarre fly, Zhenia xiai gen. et sp. nov., from Late Cretaceous Burmese amber (about 99 million years old) that represents the latest occurrence of the family Eremochaetidae. Z. xiai is an endoparasitoid insect as evidenced by a highly developed, hypodermic-like ovipositor formed by abdominal tergites VIII + IX that was used for injecting eggs into hosts and enlarged tridactylous claws supposedly for clasping hosts. Our results suggest that eremochaetids are among the earliest definite records of parasitoid insects. Our findings reveal an unexpected morphological specialization of flies and broaden our understanding of the evolution and diversity of ancient parasitoid insects.

Final crew portrait of STS-84 and Mir 23 crew in the Spacehab

NASA Image and Video Library

1997-05-22

STS084-380-019 (15-24 May 1997) --- In the last minutes of joint activity between the STS-84 and Russian Space Agency (RSA) Mir-23 crews, ten astronauts and cosmonauts pose for an in-space portrait in the Space Shuttle Atlantis Spacehab Double Module (DM). For orientation purposes, photo should be held with clasped hands of Aleksandr I. Lazutkin (wearing Mir-23 suit) just below center. The flight engineer is flanked by similarly attired crew mates Vasili Tsibliyev, Mir-23 commander, on the left, and C. Michael Foale, cosmonaut guest researcher, on the right. The STS-84 crew members are, clockwise from the left, Jerry M. Linenger, mission specialist; Eileen M. Collins, pilot; Edward T. Lu, mission specialist; Jean-Fran?ois Clervoy, payload commander; Elena V. Kondakova and Carlos I. Noriega, both mission specialists, along with Charles J. Precourt, mission commander.

STS-92 M.S. Michael Lopez-Alegria suits up for launch

NASA Technical Reports Server (NTRS)

2000-01-01

During suitup in the Operations and Checkout Building, STS-92 Mission Specialist Michael E. Lopez-Alegria smiles and clasps his hands in anticipation of a second launch attempt. He and the rest of the crew will be heading out to the Astrovan for the ride to Launch Pad 39A. During the 11-day mission to the International Space Station, four extravehicular activities (EVAs), or spacewalks, are planned for construction. The payload includes the Integrated Truss Structure Z-1 and the third Pressurized Mating Adapter. The Z-1 truss is the first of 10 that will become the backbone of the Space Station, eventually stretching the length of a football field. PMA-3 will provide a Shuttle docking port for solar array installation on the sixth Station flight and Lab installation on the seventh Station flight. Launch is scheduled for 7:17 p.m. EDT. Landing is expected Oct. 22 at 2:10 p.m. EDT.

Mapping pathological phenotypes in a mouse model of CDKL5 disorder.

PubMed

Amendola, Elena; Zhan, Yang; Mattucci, Camilla; Castroflorio, Enrico; Calcagno, Eleonora; Fuchs, Claudia; Lonetti, Giuseppina; Silingardi, Davide; Vyssotski, Alexei L; Farley, Dominika; Ciani, Elisabetta; Pizzorusso, Tommaso; Giustetto, Maurizio; Gross, Cornelius T

2014-01-01

Mutations in cyclin-dependent kinase-like 5 (CDKL5) cause early-onset epileptic encephalopathy, a neurodevelopmental disorder with similarities to Rett Syndrome. Here we describe the physiological, molecular, and behavioral phenotyping of a Cdkl5 conditional knockout mouse model of CDKL5 disorder. Behavioral analysis of constitutive Cdkl5 knockout mice revealed key features of the human disorder, including limb clasping, hypoactivity, and abnormal eye tracking. Anatomical, physiological, and molecular analysis of the knockout uncovered potential pathological substrates of the disorder, including reduced dendritic arborization of cortical neurons, abnormal electroencephalograph (EEG) responses to convulsant treatment, decreased visual evoked responses (VEPs), and alterations in the Akt/rpS6 signaling pathway. Selective knockout of Cdkl5 in excitatory and inhibitory forebrain neurons allowed us to map the behavioral features of the disorder to separable cell-types. These findings identify physiological and molecular deficits in specific forebrain neuron populations as possible pathological substrates in CDKL5 disorder.

Struvite formation and the fouling propensity of different materials.

PubMed

Doyle, J D; Oldring, K; Churchley, J; Parsons, S A

2002-09-01

Struvite (MgNH4PO4 x 6H2O) fouling was investigated to identify the impact supersaturation and material had on scaling rates. Tests were undertaken at three supersaturation ratios and with three different materials: stainless steel, teflon and acrylic. Impellers consisting of a clasp unit and two corrosion coupons that could be attached were used to mix centrate liquor and precipitation was initiated by the change in pH caused by degassing. Increasing the supersaturation ratio from 1.7 to 5.3 led to a doubling in the scaling rate of stainless-steel coupons. Experiments with acrylic and teflon coupons showed the influence of surface roughness upon scaling propensity. Coarsely roughened coupons following 40 h of mixing had a mass of 413 mg of struvite attached compared to smooth coupons that had a mass of 240 mg attached. Material did have an influence upon struvite fouling but this influence diminished with increasing surface roughness.

An endoparasitoid Cretaceous fly and the evolution of parasitoidism

NASA Astrophysics Data System (ADS)

Zhang, Qingqing; Zhang, Junfeng; Feng, Yitao; Zhang, Haichun; Wang, Bo

2016-02-01

Parasitoidism is a key innovation in insect evolution, and parasitoid insects, nowadays, play a significant role in structuring ecological communities. Despite their diversity and ecological impact, little is known about the early evolution and ecology of parasitoid insects, especially parasitoid true flies (Diptera). Here, we describe a bizarre fly, Zhenia xiai gen. et sp. nov., from Late Cretaceous Burmese amber (about 99 million years old) that represents the latest occurrence of the family Eremochaetidae. Z. xiai is an endoparasitoid insect as evidenced by a highly developed, hypodermic-like ovipositor formed by abdominal tergites VIII + IX that was used for injecting eggs into hosts and enlarged tridactylous claws supposedly for clasping hosts. Our results suggest that eremochaetids are among the earliest definite records of parasitoid insects. Our findings reveal an unexpected morphological specialization of flies and broaden our understanding of the evolution and diversity of ancient parasitoid insects.

Birefringence of magnesium fluoride in the vacuum ultraviolet and application to a half-waveplate.

PubMed

Ishikawa, Ryohko; Kano, Ryouhei; Bando, Takamasa; Suematsu, Yoshinori; Ishikawa, Shin-nosuke; Kubo, Masahito; Narukage, Noriyuki; Hara, Hirohisa; Tsuneta, Saku; Watanabe, Hiroko; Ichimoto, Kiyoshi; Aoki, Kunichika; Miyagawa, Kenta

2013-12-01

Spectro-polarimeteric observations in the vacuum-ultraviolet (VUV) region are expected to be developed as a new astrophysics diagnostic tool for investigating space plasmas with temperatures of >10(4)  K. Precise measurements of the difference in the extraordinary and ordinary refractive indices are required for developing accurate polarimeters, but reliable information on the birefringence in the VUV range is difficult to obtain. We have measured the birefringence of magnesium fluoride (MgF2) with an accuracy of better than ±4×10(-5) around the hydrogen Lyman-α line (121.57 nm). We show that MgF2 can be applied practically as a half-waveplate for the chromospheric Lyman-alpha spectro-polarimeter (CLASP) sounding rocket experiment and that the developed measurement method can be easily applied to other VUV birefringent materials at other wavelengths.

Technical match characteristics and influence of body anthropometry on playing performance in male elite team handball.

PubMed

Michalsik, Lars Bojsen; Madsen, Klavs; Aagaard, Per

2015-02-01

Modern team handball match-play imposes substantial physical and technical demands on elite players. However, only limited knowledge seems to exist about the specific working requirements in elite team handball. Thus, the purpose of this study was to examine the physical demands imposed on male elite team handball players in relation to playing position and body anthropometry. Based on continuous video recording of individual players during elite team handball match-play (62 tournament games, ∼4 players per game), computerized technical match analysis was performed in male elite team handball players along with anthropometric measurements over a 6 season time span. Technical match activities were distributed in 6 major types of playing actions (shots, breakthroughs, fast breaks, tackles, technical errors, and defense errors) and further divided into various subcategories (e.g., hard or light tackles, type of shot, claspings, screenings, and blockings). Players showed 36.9 ± 13.1 (group mean ± SD) high-intense technical playing actions per match with a mean total effective playing time of 53.85 ± 5.87 minutes. In offense, each player performed 6.0 ± 5.2 fast breaks, received 34.5 ± 21.3 tackles in total, and performed in defense 3.7 ± 3.5 blockings, 3.9 ± 3.0 claspings, and 5.8 ± 3.6 hard tackles. Wing players (84.5 ± 5.8 kg, 184.9 ± 5.7 cm) were less heavy and smaller (p < 0.001) than backcourt players (94.7 ± 7.1 kg, 191.9 ± 5.4 cm) and pivots (99.4 ± 6.2 kg, 194.8 ± 3.6 cm). In conclusion, modern male elite team handball match-play is characterized by a high number of short-term, high-intense intermittent technical playing actions. Indications of technical fatigue were observed. Physical demands differed between playing positions with wing players performing more fast breaks and less physical confrontations with opponent players than backcourt players and pivots. Body anthropometry seemed to have an important influence on playing performance because it is highly related to playing positions. The present observations suggest that male elite team handball players should implement more position-specific training regimens, while also focusing on anaerobic training and strength training.

Transoral endoscopic esophageal myotomy based on esophageal function testing in a survival porcine model.

PubMed

Perretta, Silvana; Dallemagne, Bernard; Donatelli, Gianfranco; Diemunsch, Pierre; Marescaux, Jacques

2011-01-01

The most effective treatment of achalasia is Heller myotomy. To explore a submucosal endoscopic myotomy technique tailored on esophageal physiology testing and to compare it with the open technique. Prospective acute and survival comparative study in pigs (n = 12; 35 kg). University animal research center. Eight acute-4 open and 4 endoscopic-myotomies followed by 4 survival endoscopic procedures. Preoperative and postoperative manometry; esophagogastric junction (EGJ) distensibility before and after selective division of muscular fibers at the EGJ and after the myotomy was prolonged to a standard length by using the EndoFLIP Functional Lumen Imaging Probe (Crospon, Galway, Ireland). All procedures were successful, with no intraoperative and postoperative complications. In the survival group, the animals recovered promptly from surgery. Postoperative manometry demonstrated a 50% drop in mean lower esophageal sphincter pressure (LESp) in the endoscopic group (mean preoperative LESp, 22.2 ± 3.3 mm Hg; mean postoperative LESp, 11.34 ± 2.7 mm Hg; P < .005) and a 69% loss in the open procedure group (mean preoperative LESp, 24.2 ± 3.2 mm Hg; mean postoperative LESp, 7.4 ± 4 mm Hg; P < .005). The EndoFLIP monitoring did not show any distensibility difference between the 2 techniques, with the main improvement occurring when the clasp circular fibers were taken. Healthy animal model; small sample. Endoscopic submucosal esophageal myotomy is feasible and safe. The lack of a significant difference in EGJ distensibility between the open and endoscopic procedure is very appealing. Were it to be perfected in a human population, this endoscopic approach could suggest a new strategy in the treatment of selected achalasia patients. Copyright © 2011 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.

Glass fiber-reinforced thermoplastics for use in metal-free removable partial dentures: combined effects of fiber loading and pigmentation on color differences and flexural properties.

PubMed

Tanimoto, Yasuhiro; Nagakura, Manamu; Nishiyama, Norihiro

2018-02-21

The purpose of this study was to investigate the combined effects of fiber loading and pigmentation on the color differences and flexural properties of glass fiber-reinforced thermoplastics (GFRTPs), for use in non-metal clasp dentures (NMCDs). The GFRTPs consisted mainly of E-glass fibers, a polypropylene matrix, and a coloring pigment: the GFRTPs with various fiber loadings (0, 10, and 20mass%) and pigmentations (0, 1, 2, and 4mass%) were fabricated by using an injection molding. The color differences of GFRTPs were measured based on the Commission Internationale de l'Eclairage (CIE) Lab color system, by comparing with a commercially available NMCD. The flexural properties of GFRTPs were evaluated by using a three-point bending test, according to International Standards Organization (ISO) specification number 20795-1. The visible colors of GFRTPs with pigment contents of 2mass% were acceptable for gingival color, and the glass fibers harmonized well with the resins. The ΔE* values of the GFRTPs with pigment contents of 2mass% obtained by using the CIE Lab system were lowest at all fiber loadings. For GFRTPs with fiber contents of 10 and 20mass% at 2mass% pigment content, these GFRTPs surpassed the ISO 20795-1 specification regarding flexural strength (> 60MPa) and modulus (> 1.5GPa). A combination of the results of color difference evaluation and mechanical examination indicates that the GFRTPs with fiber contents of 10 or 20mass%, and with pigment contents of 2mass% have acceptable esthetic appearance and sufficient rigidity for NMCDs. Copyright © 2018 Japan Prosthodontic Society. Published by Elsevier Ltd. All rights reserved.

Laparoscopic prototype for optical sealing of renal blood vessels

NASA Astrophysics Data System (ADS)

Hardy, Luke A.; Hutchens, Thomas C.; Larson, Eric R.; Gonzalez, David A.; Chang, Chun-Hung; Nau, William H.; Fried, Nathaniel M.

2017-02-01

Energy-based, radiofrequency and ultrasonic devices provide rapid sealing of blood vessels during laparoscopic procedures. We are exploring infrared lasers as an alternative for vessel sealing with less collateral thermal damage. Previous studies demonstrated vessel sealing in an in vivo porcine model using a 1470-nm laser. However, the initial prototype was designed for open surgery and featured tissue clasping and light delivery mechanisms incompatible with laparoscopic surgery. In this study, a laparoscopic prototype similar to devices in surgical use was developed, and tests were conducted on porcine renal blood vessels. The 5-mm-OD prototype featured a traditional Maryland jaw configuration. Laser energy was delivered through a 550-μm-core fiber and side-delivery from the lower jaw, with beam dimensions of 18-mm-length x 1.2-mm-width. The 1470-nm diode laser delivered 68 W with 3 s activation time. A total of 69 porcine renal vessels with mean diameter of 3.3 +/- 1.7 mm were tested, ex vivo. Vessels smaller than 5 mm were consistently sealed (48/51) with burst pressures greater than malignant hypertension blood pressure (180 mmHg), averaging 1038 +/- 474 mmHg. Vessels larger than 5 mm were not consistently sealed (6/18), yielding burst pressures of only 174 +/- 221 mmHg. Seal width, thermal damage zone, and thermal spread averaged 1.7 +/- 0.8, 3.4 +/- 0.7, and 1.0 +/- 0.4 mm. A novel optical laparoscopic prototype with 5-mm- OD shaft integrated within a standard Maryland jaw design consistently sealed vessels less than 5 mm with minimal thermal spread. Further in vivo studies are planned to test performance across a variety of vessels and tissues.

41 CFR 101-29.221 - Federal Specifications, Standards and Commercial Item Description Program (Federal...

Code of Federal Regulations, 2010 CFR

2010-07-01

... standardization program developed under authority of the Federal Property and Administrative Services Act of 1949..., Standards and Commercial Item Description Program (Federal Standardization Program). 101-29.221 Section 101...-Definitions § 101-29.221 Federal Specifications, Standards and Commercial Item Description Program (Federal...

41 CFR 101-29.221 - Federal Specifications, Standards and Commercial Item Description Program (Federal...

Code of Federal Regulations, 2011 CFR

2011-07-01

... standardization program developed under authority of the Federal Property and Administrative Services Act of 1949..., Standards and Commercial Item Description Program (Federal Standardization Program). 101-29.221 Section 101...-Definitions § 101-29.221 Federal Specifications, Standards and Commercial Item Description Program (Federal...

On the importance of body posture and skin modelling with respect to in situ electric field strengths in magnetic field exposure scenarios

NASA Astrophysics Data System (ADS)

Schmid, Gernot; Hirtl, Rene

2016-06-01

The reference levels and maximum permissible exposure values for magnetic fields that are currently used have been derived from basic restrictions under the assumption of upright standing body models in a standard posture, i.e. with arms laterally down and without contact with metallic objects. Moreover, if anatomical modelling of the body was used at all, the skin was represented as a single homogeneous tissue layer. In the present paper we addressed the possible impacts of posture and skin modelling in scenarios of exposure to a 50 Hz uniform magnetic field on the in situ electric field strength in peripheral tissues, which must be limited in order to avoid peripheral nerve stimulation. We considered different body postures including situations where body parts form large induction loops (e.g. clasped hands) with skin-to-skin and skin-to-metal contact spots and compared the results obtained with a homogeneous single-layer skin model to results obtained with a more realistic two-layer skin representation consisting of a low-conductivity stratum corneum layer on top of a combined layer for the cellular epidermis and dermis. Our results clearly indicated that postures with loops formed of body parts may lead to substantially higher maximum values of induced in situ electric field strengths than in the case of standard postures due to a highly concentrated current density and in situ electric field strength in the skin-to-skin and skin-to-metal contact regions. With a homogeneous single-layer skin, as is used for even the most recent anatomical body models in exposure assessment, the in situ electric field strength may exceed the basic restrictions in such situations, even when the reference levels and maximum permissible exposure values are not exceeded. However, when using the more realistic two-layer skin model the obtained in situ electric field strengths were substantially lower and no violations of the basic restrictions occurred, which can be explained by the current-limiting effect of the low-conductivity stratum corneum layer.

Business Education. Vocational Education Program Courses Standards.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee. Div. of Vocational, Adult, and Community Education.

This document contains vocational education program courses standards (curriculum frameworks and student performance standards) for business technology education programs in Florida. Each program courses standard is composed of two parts: a curriculum framework and student performance standards. The curriculum framework includes four major…

Recommended Standards: Common to All Programs; Specific to Production Agriculture, Secondary; Specific to Adult Education for Quality Agriculture/Agribusiness Programs in Kansas.

ERIC Educational Resources Information Center

Kansas State Univ., Manhattan. Dept. of Adult and Occupational Education.

This document contains recommended standards for quality vocational programs in agricultural/agribusiness education which are divided into (1) standards common to all programs, (2) standards specific to adult education in agriculture/agribusiness, and (3) standards specific to production agriculture, secondary. The sixty common standards are…

Technology Education. Vocational Education Program Courses Standards.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee. Div. of Vocational, Adult, and Community Education.

This document contains vocational education program course standards for technology education programs in Florida. Standards are provided for a total of 32 exploratory courses, practical arts courses, and pretechnical programs offered at the secondary or postsecondary level. Each program course standard consists of a curriculum framework and…

Health Occupations Education. Vocational Education Program Courses Standards.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee. Div. of Vocational, Adult, and Community Education.

This document contains vocational education program course standards for health occupations programs in Florida. Standards are provided for a total of 71 exploratory courses, practical arts courses, and job preparatory programs offered at the secondary or postsecondary level. Each program courses standard consists of a curriculum framework and…

14 CFR 151.99 - Modifications of programming standards.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Modifications of programming standards. 151... (CONTINUED) AIRPORTS FEDERAL AID TO AIRPORTS Project Programming Standards § 151.99 Modifications of programming standards. The Director, Airports, Service, or the Regional Director concerned may, on individual...

14 CFR 151.99 - Modifications of programming standards.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Modifications of programming standards. 151... (CONTINUED) AIRPORTS FEDERAL AID TO AIRPORTS Project Programming Standards § 151.99 Modifications of programming standards. The Director, Airports, Service, or the Regional Director concerned may, on individual...

14 CFR 151.99 - Modifications of programming standards.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Modifications of programming standards. 151... (CONTINUED) AIRPORTS FEDERAL AID TO AIRPORTS Project Programming Standards § 151.99 Modifications of programming standards. The Director, Airports, Service, or the Regional Director concerned may, on individual...

Industrial Education. Vocational Education Program Courses Standards.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee. Div. of Vocational, Adult, and Community Education.

This document contains vocational education program courses standards (curriculum frameworks and student performance standards) for exploratory courses, practical arts courses, and job preparatory programs offered at the secondary or postsecondary level in Florida. Each program courses standard is composed of two parts: a curriculum framework and…

14 CFR 151.99 - Modifications of programming standards.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Modifications of programming standards. 151... (CONTINUED) AIRPORTS FEDERAL AID TO AIRPORTS Project Programming Standards § 151.99 Modifications of programming standards. The Director, Airports, Service, or the Regional Director concerned may, on individual...

14 CFR 151.99 - Modifications of programming standards.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Modifications of programming standards. 151... (CONTINUED) AIRPORTS FEDERAL AID TO AIRPORTS Project Programming Standards § 151.99 Modifications of programming standards. The Director, Airports, Service, or the Regional Director concerned may, on individual...

Modification and Adaptation of the Program Evaluation Standards in Saudi Arabia

ERIC Educational Resources Information Center

Alyami, Mohammed

2013-01-01

The Joint Committee on Standards for Educational Evaluation's Program Evaluation Standards is probably the most recognized and applied set of evaluation standards globally. The most recent edition of The Program Evaluation Standards includes five categories and 30 standards. The five categories are Utility, Feasibility, Propriety, Accuracy, and…

NASA Technical Standards Program

NASA Technical Reports Server (NTRS)

Gill, Paul S.; Vaughan, William W.; Parker, Nelson C. (Technical Monitor)

2002-01-01

The NASA Technical Standards Program was officially established in 1997 as result of a directive issued by the Administrator. It is responsible for Agency wide technical standards development, adoption (endorsement), and conversion of Center-unique standards for Agency wide use. One major element of the Program is the review of NSA technical standards products and replacement with non-Government Voluntary Consensus Standards in accordance with directions issued by the Office of Management and Budget. As part of the Program's function, it developed a NASA Integrated Technical Standards Initiative that consists of and Agency wide full-text system, standards update notification system, and lessons learned-standards integration system. The Program maintains a 'one stop-shop' Website for technical standards ad related information on aerospace materials, etc. This paper provides information on the development, current status, and plans for the NAS Technical Standards Program along with metrics on the utility of the products provided to both users within the nasa.gov Domain and the Public Domain.

NASA Technical Standards Program

NASA Technical Reports Server (NTRS)

Gill, Paul S.; Vaughan, WIlliam W.

2003-01-01

The NASA Technical Standards Program was officially established in 1997 as result of a directive issued by the Administrator. It is responsible for Agency wide technical standards development, adoption (endorsement), and conversion of Center-unique standards for Agency wide use. One major element of the Program is the review of NSA technical standards products and replacement with non-Government Voluntary Consensus Standards in accordance with directions issued by the Office of Management and Budget. As part of the Program s function, it developed a NASA Integrated Technical Standards Initiative that consists of and Agency wide full-text system, standards update notification system, and lessons learned - standards integration system. The Program maintains a "one stop-shop" Website for technical standards ad related information on aerospace materials, etc. This paper provides information on the development, current status, and plans for the NAS Technical Standards Program along with metrics on the utility of the products provided to both users within the nasa.gov Domain and the Public Domain.

Development of NASA Technical Standards Program Relative to Enhancing Engineering Capabilities

NASA Technical Reports Server (NTRS)

Gill, Paul S.; Vaughan, William W.

2003-01-01

The enhancement of engineering capabilities is an important aspect of any organization; especially those engaged in aerospace development activities. Technical Standards are one of the key elements of this endeavor. The NASA Technical Standards Program was formed in 1997 in response to the NASA Administrator s directive to develop an Agencywide Technical Standards Program. The Program s principal objective involved the converting Center-unique technical standards into Agency wide standards and the adoption/endorsement of non-Government technical standards in lieu of government standards. In the process of these actions, the potential for further enhancement of the Agency s engineering capabilities was noted relative to value of being able to access Agencywide the necessary full-text technical standards, standards update notifications, and integration of lessons learned with technical standards, all available to the user from one Website. This was accomplished and is now being enhanced based on feedbacks from the Agency's engineering staff and supporting contractors. This paper addresses the development experiences with the NASA Technical Standards Program and the enhancement of the Agency's engineering capabilities provided by the Program s products. Metrics are provided on significant aspects of the Program.

Eddy covariance measurements of sea spray particles over the Atlantic Ocean

NASA Astrophysics Data System (ADS)

Norris, S. J.; Brooks, I. M.; de Leeuw, G.; Smith, M. H.; Moerman, M.; Lingard, J. J. N.

2008-02-01

Most estimates of sea spray aerosol source functions have used indirect means to infer the rate of production as a function of wind speed. Only recently has the technology become available to make high frequency measurements of aerosol spectra suitable for direct eddy correlation determination of the sea spray particle flux. This was accomplished in this study by combining a newly developed fast aerosol particle counter with an ultrasonic anemometer which allowed for eddy covariance measurements of size-segregated particle fluxes. The aerosol instrument is the Compact Lightweight Aerosol Spectrometer Probe (CLASP) - capable of measuring 8-channel size spectra for mean radii between 0.15 and 3.5 µm at 10 Hz. The first successful measurements were made during the Waves, Air Sea Fluxes, Aerosol and Bubbles (WASFAB) field campaign in October 2005 in Duck (NC, USA). The method and initial results are presented and comparisons are made with recent sea spray source functions from the literature.

Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brosey, Chris A.; Ho, Chris; Long, Winnie Z.

Apoptosis-inducing factor (AIF) is critical for mitochondrial respiratory complex biogenesis and for mediating necroptotic parthanatos; these functions are seemingly regulated by enigmatic allosteric switching driven by NADH charge-transfer complex (CTC) formation. In this paper, we define molecular pathways linking AIF's active site to allosteric switching regions by characterizing dimer-permissive mutants using small-angle X-ray scattering (SAXS) and crystallography and by probing AIF-CTC communication networks using molecular dynamics simulations. Collective results identify two pathways propagating allostery from the CTC active site: (1) active-site H454 links to S480 of AIF's central β-strand to modulate a hydrophobic border at the dimerization interface, and (2)more » an interaction network links AIF's FAD cofactor, central β-strand, and Cβ-clasp whereby R529 reorientation initiates C-loop release during CTC formation. Finally, this knowledge of AIF allostery and its flavoswitch mechanism provides a foundation for biologically understanding and biomedically controlling its participation in mitochondrial homeostasis and cell death.« less

Effect of fiber content on flexural properties of glass fiber-reinforced polyamide-6 prepared by injection molding.

PubMed

Nagakura, Manamu; Tanimoto, Yasuhiro; Nishiyama, Norihiro

2017-07-26

The use of non-metal clasp denture (NMCD) materials may seriously affect the remaining tissues because of the low rigidity of NMCD materials such as polyamides. The purpose of this study was to develop a high-rigidity glass fiber-reinforced thermoplastic (GFRTP) composed of E-glass fiber and polyamide-6 for NMCDs using an injection molding. The reinforcing effects of fiber on the flexural properties of GFRTPs were investigated using glass fiber content ranging from 0 to 50 mass%. Three-point bending tests indicated that the flexural strength and elastic modulus of a GFRTP with a fiber content of 50 mass% were 5.4 and 4.7 times higher than those of unreinforced polyamide-6, respectively. The result showed that the physical characteristics of GFRTPs were greatly improved by increasing the fiber content, and the beneficial effects of fiber reinforcement were evident. The findings suggest that the injection-molded GFRTPs are adaptable to NMCDs because of their excellent mechanical properties.

The Piriform Cortex and Human Focal Epilepsy

PubMed Central

Vaughan, David N.; Jackson, Graeme D.

2014-01-01

It is surprising that the piriform cortex, when compared to the hippocampus, has been given relatively little significance in human epilepsy. Like the hippocampus, it has a phylogenetically preserved three-layered cortex that is vulnerable to excitotoxic injury, has broad connections to both limbic and cortical areas, and is highly epileptogenic – being critical to the kindling process. The well-known phenomenon of early olfactory auras in temporal lobe epilepsy highlights its clinical relevance in human beings. Perhaps because it is anatomically indistinct and difficult to approach surgically, as it clasps the middle cerebral artery, it has, until now, been understandably neglected. In this review, we emphasize how its unique anatomical and functional properties, as primary olfactory cortex, predispose it to involvement in focal epilepsy. From recent convergent findings in human neuroimaging, clinical epileptology, and experimental animal models, we make the case that the piriform cortex is likely to play a facilitating and amplifying role in human focal epileptogenesis, and may influence progression to epileptic intractability. PMID:25538678

Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor

DOE PAGES

Brosey, Chris A.; Ho, Chris; Long, Winnie Z.; ...

2016-11-03

Apoptosis-inducing factor (AIF) is critical for mitochondrial respiratory complex biogenesis and for mediating necroptotic parthanatos; these functions are seemingly regulated by enigmatic allosteric switching driven by NADH charge-transfer complex (CTC) formation. In this paper, we define molecular pathways linking AIF's active site to allosteric switching regions by characterizing dimer-permissive mutants using small-angle X-ray scattering (SAXS) and crystallography and by probing AIF-CTC communication networks using molecular dynamics simulations. Collective results identify two pathways propagating allostery from the CTC active site: (1) active-site H454 links to S480 of AIF's central β-strand to modulate a hydrophobic border at the dimerization interface, and (2)more » an interaction network links AIF's FAD cofactor, central β-strand, and Cβ-clasp whereby R529 reorientation initiates C-loop release during CTC formation. Finally, this knowledge of AIF allostery and its flavoswitch mechanism provides a foundation for biologically understanding and biomedically controlling its participation in mitochondrial homeostasis and cell death.« less

Vacuum ultraviolet spectropolarimeter design for precise polarization measurements.

PubMed

Narukage, Noriyuki; Auchère, Frédéric; Ishikawa, Ryohko; Kano, Ryouhei; Tsuneta, Saku; Winebarger, Amy R; Kobayashi, Ken

2015-03-10

Precise polarization measurements in the vacuum ultraviolet (VUV) region provide a new means for inferring weak magnetic fields in the upper atmosphere of the Sun and stars. We propose a VUV spectropolarimeter design ideally suited for this purpose. This design is proposed and adopted for the NASA-JAXA chromospheric lyman-alpha spectropolarimeter (CLASP), which will record the linear polarization (Stokes Q and U) of the hydrogen Lyman-α line (121.567 nm) profile. The expected degree of polarization is on the order of 0.1%. Our spectropolarimeter has two optically symmetric channels to simultaneously measure orthogonal linear polarization states with a single concave diffraction grating that serves both as the spectral dispersion element and beam splitter. This design has a minimal number of reflective components with a high VUV throughput. Consequently, these design features allow us to minimize the polarization errors caused by possible time variation of the VUV flux during the polarization modulation and by statistical photon noise.

A mitotic SKAP isoform regulates spindle positioning at astral microtubule plus ends

PubMed Central

Kern, David M.; Nicholls, Peter K.; Page, David C.

2016-01-01

The Astrin/SKAP complex plays important roles in mitotic chromosome alignment and centrosome integrity, but previous work found conflicting results for SKAP function. Here, we demonstrate that SKAP is expressed as two distinct isoforms in mammals: a longer, testis-specific isoform that was used for the previous studies in mitotic cells and a novel, shorter mitotic isoform. Unlike the long isoform, short SKAP rescues SKAP depletion in mitosis and displays robust microtubule plus-end tracking, including localization to astral microtubules. Eliminating SKAP microtubule binding results in severe chromosome segregation defects. In contrast, SKAP mutants specifically defective for plus-end tracking facilitate proper chromosome segregation but display spindle positioning defects. Cells lacking SKAP plus-end tracking have reduced Clasp1 localization at microtubule plus ends and display increased lateral microtubule contacts with the cell cortex, which we propose results in unbalanced dynein-dependent cortical pulling forces. Our work reveals an unappreciated role for the Astrin/SKAP complex as an astral microtubule mediator of mitotic spindle positioning. PMID:27138257

Mapping Pathological Phenotypes in a Mouse Model of CDKL5 Disorder

PubMed Central

Amendola, Elena; Zhan, Yang; Mattucci, Camilla; Castroflorio, Enrico; Calcagno, Eleonora; Fuchs, Claudia; Lonetti, Giuseppina; Silingardi, Davide; Vyssotski, Alexei L.; Farley, Dominika; Ciani, Elisabetta; Pizzorusso, Tommaso; Giustetto, Maurizio; Gross, Cornelius T.

2014-01-01

Mutations in cyclin-dependent kinase-like 5 (CDKL5) cause early-onset epileptic encephalopathy, a neurodevelopmental disorder with similarities to Rett Syndrome. Here we describe the physiological, molecular, and behavioral phenotyping of a Cdkl5 conditional knockout mouse model of CDKL5 disorder. Behavioral analysis of constitutive Cdkl5 knockout mice revealed key features of the human disorder, including limb clasping, hypoactivity, and abnormal eye tracking. Anatomical, physiological, and molecular analysis of the knockout uncovered potential pathological substrates of the disorder, including reduced dendritic arborization of cortical neurons, abnormal electroencephalograph (EEG) responses to convulsant treatment, decreased visual evoked responses (VEPs), and alterations in the Akt/rpS6 signaling pathway. Selective knockout of Cdkl5 in excitatory and inhibitory forebrain neurons allowed us to map the behavioral features of the disorder to separable cell-types. These findings identify physiological and molecular deficits in specific forebrain neuron populations as possible pathological substrates in CDKL5 disorder. PMID:24838000

Protein design on computers. Five new proteins: Shpilka, Grendel, Fingerclasp, Leather, and Aida.

PubMed

Sander, C; Vriend, G; Bazan, F; Horovitz, A; Nakamura, H; Ribas, L; Finkelstein, A V; Lockhart, A; Merkl, R; Perry, L J

1992-02-01

What is the current state of the art in protein design? This question was approached in a recent two-week protein design workshop sponsored by EMBO and held at the EMBL in Heidelberg. The goals were to test available design tools and to explore new design strategies. Five novel proteins were designed: Shpilka, a sandwich of two four-stranded beta-sheets, a scaffold on which to explore variations in loop topology; Grendel, a four-helical membrane anchor, ready for fusion to water-soluble functional domains; Finger-clasp, a dimer of interdigitating beta-beta-alpha units, the simplest variant of the "handshake" structural class; Aida, an antibody binding surface intended to be specific for flavodoxin; Leather--a minimal NAD binding domain, extracted from a larger protein. Each design is available as a set of three-dimensional coordinates, the corresponding amino acid sequence and a set of analytical results. The designs are placed in the public domain for scrutiny, improvement, and possible experimental verification.

Health Occupations Education. Vocational Education Program Courses Standards.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee. Div. of Vocational, Adult, and Community Education.

This document contains vocational education program courses standards for exploratory courses, practical arts courses, and job preparatory programs offered at the secondary or postsecondary level. Each program standard is composed of two parts: a curriculum framework and student performance standards. The curriculum framework includes four major…

DOE standard: The Department of Energy Laboratory Accreditation Program for radiobioassay

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-12-01

This technical standard describes the US Department of Energy Laboratory Accreditation Program (DOELAP) for Radiobioassay, for use by the US Department of Energy (DOE) and DOE Contractor radiobioassay programs. This standard is intended to be used in conjunction with the general administrative technical standard that describes the overall DOELAP accreditation process--DOE-STD-1111-98, Department of Energy Laboratory Accreditation Program Administration. This technical standard pertains to radiobioassay service laboratories that provide either direct or indirect (in vivo or in vitro) radiobioassay measurements in support of internal dosimetry programs at DOE facilities or for DOE and DOE contractors. Similar technical standards have been developedmore » for other DOELAP dosimetry programs. This program consists of providing an accreditation to DOE radiobioassay programs based on successful completion of a performance-testing process and an on-site evaluation by technical experts. This standard describes the technical requirements and processes specific to the DOELAP Radiobioassay Accreditation Program as required by 10 CFR 835 and as specified generically in DOE-STD-1111-98.« less

25 CFR 36.20 - Standard V-Minimum academic programs/school calendar.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 1 2012-04-01 2011-04-01 true Standard V-Minimum academic programs/school calendar. 36... ACADEMIC STANDARDS FOR THE BASIC EDUCATION OF INDIAN CHILDREN AND NATIONAL CRITERIA FOR DORMITORY SITUATIONS Minimum Program of Instruction § 36.20 Standard V—Minimum academic programs/school calendar. (a...

25 CFR 36.20 - Standard V-Minimum academic programs/school calendar.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false Standard V-Minimum academic programs/school calendar. 36... ACADEMIC STANDARDS FOR THE BASIC EDUCATION OF INDIAN CHILDREN AND NATIONAL CRITERIA FOR DORMITORY SITUATIONS Minimum Program of Instruction § 36.20 Standard V—Minimum academic programs/school calendar. (a...

25 CFR 36.20 - Standard V-Minimum academic programs/school calendar.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false Standard V-Minimum academic programs/school calendar. 36... ACADEMIC STANDARDS FOR THE BASIC EDUCATION OF INDIAN CHILDREN AND NATIONAL CRITERIA FOR DORMITORY SITUATIONS Minimum Program of Instruction § 36.20 Standard V—Minimum academic programs/school calendar. (a...

Masonry Program Standards.

ERIC Educational Resources Information Center

Georgia Univ., Athens. Dept. of Vocational Education.

This publication contains statewide standards for the masonry program in Georgia. The standards are divided into 12 categories: foundations (philosophy, purpose, goals, program objectives, availability, evaluation); admissions (admission requirements, provisional admission requirements, recruitment, evaluation and planning); program structure…

Maternal Quality Standards for Children's Television Programs.

ERIC Educational Resources Information Center

Nikken, Peter; And Others

1996-01-01

Investigates the standards mothers use to evaluate four types of children's television programs: (1) cartoons; (2) news programs for children; (3) educational children's programs; and (4) dramatic children's programs. Three quality standards considered most important were comprehensibility, aesthetic quality, and elicitation of involvement.…

Airborne fibre and asbestos concentrations in system built schools

NASA Astrophysics Data System (ADS)

Burdett, Garry; Cottrell, Steve; Taylor, Catherine

2009-02-01

This paper summarises the airborne fibre concentration data measured in system built schools that contained asbestos insulation board (AIB) enclosed in the support columns by a protective steel casing. The particular focus of this work was the CLASP (Consortium of Local Authorities Special Programme) system buildings. A variety of air monitoring tests were carried out to assess the potential for fibres to be released into the classroom. A peak release testing protocol was adopted that involved static sampling, while simulating direct impact disturbances to selected columns. This was carried out before remediation, after sealing gaps and holes in and around the casing visible in the room (i.e. below ceiling level) and additionally round the tops of the columns, which extended into the suspended ceiling void. Simulated and actual measurements of worker exposures were also undertaken, while sealing columns, carrying out cleaning and maintenance work in the ceiling voids. Routine analysis of these air samples was carried out by phase contrast microscopy (PCM) with a limited amount of analytical transmission electron microscopy (TEM) analysis to confirm whether the fibres visible by PCM were asbestos or non-asbestos. The PCM fibre concentrations data from the peak release tests showed that while direct releases of fibres to the room air can occur from gaps and holes in and around the column casings, sealing is an effective way of minimising releases to below the limit of quantification (0.01 f/ml) of the PCM method for some 95% of the tests carried out. Sealing with silicone filler and taping any gaps and seams visible on the column casing in the room, also gave concentrations below the limit of quantification (LOQ) of the PCM method for 95% of the tests carried out. The data available did not show any significant difference between the PCM fibre concentrations in the room air for columns that had or had not been sealed in the ceiling void, as well as in the room. Occupant exposures during normal classroom teaching activities in areas that had undergone remediation were also monitored with much greater use of TEM analysis to determine the asbestos fibre concentration. No asbestos fibres were found in the TEM analysis of samples of classroom air from seven schools, after remediation had taken place. Occupant exposures in one school and one office building have been monitored before remediation and only one asbestos fibre was found in each set of samples analysed. The average monitored occupant exposures to asbestos in CLASP buildings was <0.00005 f/ml, an order of magnitude lower than previous measurements in UK buildings.

Technical activity profile and influence of body anthropometry on playing performance in female elite team handball.

PubMed

Michalsik, Lars B; Aagaard, Per; Madsen, Klavs

2015-04-01

To determine the physical demands placed on female elite team handball (TH) players in relation to playing position and body anthropometry, female elite TH primarily field players were monitored during match-play using video recording and subsequent computerized technical match analysis during 5 regular tournament match seasons. Technical match activities were distributed in 6 major types of playing actions (shots, breakthroughs, fast breaks, technical errors, defensive errors, and tackles) and further divided into various subcategories (e.g., type of shot, hard or light tackles, claspings, screenings, and blockings). Furthermore, anthropometric measurements were performed. Each player had 28.3 ± 11.0 (group means ± SD) high-intense playing actions per match with a total effective playing time of 50.70 ± 5.83 minutes. On average, each player made 2.8 ± 2.6 fast breaks, gave 7.9 ± 14.4 screenings, received 14.6 ± 9.2 tackles in total, and performed 7.7 ± 3.7 shots while in offense, along with 3.5 ± 3.8 blockings, 1.9 ± 2.7 claspings, and 6.2 ± 3.8 hard tackles in defense. Mean body height, body mass, and age in the Danish Premier Female Team Handball League were 175.4 ± 6.1 cm, 69.5 ± 6.5 kg, and 25.4 ± 3.7 years, respectively. Wing players were lighter (63.5 ± 4.8 kg, p < 0.001) and smaller (169.3 ± 4.9 cm, p < 0.001) than backcourt players (BP) (70.6 ± 5.3 kg, 177.0 ± 5.4 cm) and pivots (PV) (72.5 ± 4.9 kg, 177.7 ± 4.9 cm). In conclusion, the present match observations revealed that female elite TH players during competitive games intermittently perform a high number of short-term, high-intense technical playing actions making modern female elite TH a physically demanding team sport. No sign of technical fatigue were observed, since the amount of intense technical playing actions remained unchanged in the second half. Marked positional differences in the physical demands were demonstrated, with wing players performing more fast breaks and less physical confrontations than BP and PV. Body anthropometry differed substantially between different playing positions. Consequently, this should lead to an increase in physical training in modern female elite TH directed at specific positions and individual physical capacity.

The CAEP Standards and Research on Educator Preparation Programs: Linking Clinical Partnerships with Program Impact

ERIC Educational Resources Information Center

Heafner, Tina; McIntyre, Ellen; Spooner, Melba

2014-01-01

Responding to the challenge of more rigorous and outcome-oriented program evaluation criteria of the Council for the Accreditation of Educator Preparation (CAEP), authors take a critical look at the intersection of two standards: Clinical Partnerships and Practice (Standard 2) and Program Impact (Standard 4). Illustrating one aspect of a secondary…

41 CFR 102-194.5 - What is the Standard and Optional Forms Management Program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What is the Standard and Optional Forms Management Program? 102-194.5 Section 102-194.5 Public Contracts and Property Management... PROGRAMS 194-STANDARD AND OPTIONAL FORMS MANAGEMENT PROGRAM § 102-194.5 What is the Standard and Optional...

76 FR 47518 - Energy Conservation Program: Treatment of “Smart” Appliances in Energy Conservation Standards and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-05

... Conservation Program: Treatment of ``Smart'' Appliances in Energy Conservation Standards and Test Procedures... well as in test procedures used to demonstrate compliance with DOE's standards and qualification as an... development of energy conservation standards and test procedures for DOE's Appliance Standards Program and the...

78 FR 79659 - Chronic Wasting Disease Herd Certification Program and Interstate Movement of Farmed or Captive...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-31

...We are giving notice of changes to the Program Standards for the chronic wasting disease (CWD) herd certification program. The CWD herd certification program is a voluntary, cooperative program that establishes minimum requirements for the interstate movement of farmed or captive cervids, provisions for participating States to administer Approved State CWD Herd Certification Programs, and provisions for participating herds to become certified as having a low risk of being infected with CWD. The Program Standards provide optional guidance, explanation, and clarification on how to meet the requirements for interstate movement and for the Herd Certification Programs. Recently, we convened a group of State, laboratory, and industry representatives to discuss possible changes to the current Program Standards. The revised Program Standards reflect these discussions, and we believe the revised version will improve understanding of the program among State and industry cooperators. We are making the revised version of the Program Standards available for review and comment.

Use of telemedicine in the remote programming of cochlear implants.

PubMed

Ramos, Angel; Rodriguez, Carina; Martinez-Beneyto, Paz; Perez, Daniel; Gault, Alexandre; Falcon, Juan Carlos; Boyle, Patrick

2009-05-01

Remote cochlear implant (CI) programming is a viable, safe, user-friendly and cost-effective procedure, equivalent to standard programming in terms of efficacy and user's perception, which can complement the standard procedures. The potential benefits of this technique are outlined. We assessed the technical viability, risks and difficulties of remote CI programming; and evaluated the benefits for the user comparing the standard on-site CI programming versus the remote CI programming. The Remote Programming System (RPS) basically consists of completing the habitual programming protocol in a regular CI centre, assisted by local staff, although guided by a remote expert, who programs the CI device using a remote programming station that takes control of the local station through the Internet. A randomized prospective study has been designed with the appropriate controls comparing RPS to the standard on-site CI programming. Study subjects were implanted adults with a HiRes 90K(R) CI with post-lingual onset of profound deafness and 4-12 weeks of device use. Subjects underwent two daily CI programming sessions either remote or standard, on 4 programming days separated by 3 month intervals. A total of 12 remote and 12 standard sessions were completed. To compare both CI programming modes we analysed: program parameters, subjects' auditory progress, subjects' perceptions of the CI programming sessions, and technical aspects, risks and difficulties of remote CI programming. Control of the local station from the remote station was carried out successfully and remote programming sessions were achieved completely and without incidents. Remote and standard program parameters were compared and no significant differences were found between the groups. The performance evaluated in subjects who had been using either standard or remote programs for 3 months showed no significant difference. Subjects were satisfied with both the remote and standard sessions. Safety was proven by checking emergency stops in different conditions. A very small delay was noticed that did not affect the ease of the fitting. The oral and video communication between the local and the remote equipment was established without difficulties and was of high quality.

Standards for Adult Education ESL Programs

ERIC Educational Resources Information Center

TESOL Press, 2013

2013-01-01

What are the components of a quality education ESL program? TESOL's "Standards for Adult Education ESL Programs" answers this question by defining quality components from a national perspective. Using program indicators in eight distinct areas, the standards can be used to review an existing program or as a guide in setting up a new…

Marketing Education. Vocational Education Program Courses Standards.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee. Div. of Vocational, Adult, and Community Education.

This document contains vocational education program courses standards (curriculum frameworks and student performance standards) for exploratory courses, practical arts courses, and job preparatory programs in marketing offered at the secondary or postsecondary level as a part of Florida's comprehensive vocational education program. Each standard…

41 CFR 101-26.501-2 - Standardized buying programs.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 26-PROCUREMENT SOURCES AND PROGRAM 26.5-GSA Procurement Programs § 101-26.501-2 Standardized buying programs. Wherever... school age passenger. (4) Sedans and station wagons (based on standardized, consolidated requirements...

Marketing Education. Vocational Education Program Courses Standards.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee. Div. of Vocational, Adult, and Community Education.

This document contains vocational education program courses standards (curriculum frameworks and student performance standards) for exploratory courses, practical arts courses, and job preparatory programs in marketing education offered at the secondary or postsecondary level as a part of Florida's comprehensive vocational education program.…

14 CFR 91.1017 - Amending program manager's management specifications.

Code of Federal Regulations, 2014 CFR

2014-01-01

... proposed amendment. (2) The Flight Standards District Office that issued the program manager's management... presented, the Flight Standards District Office that issued the program manager's management specifications... Standards District Office that issued the program manager's management specifications issues an amendment of...

14 CFR 91.1017 - Amending program manager's management specifications.

Code of Federal Regulations, 2012 CFR

2012-01-01

... proposed amendment. (2) The Flight Standards District Office that issued the program manager's management... presented, the Flight Standards District Office that issued the program manager's management specifications... Standards District Office that issued the program manager's management specifications issues an amendment of...

Technology Education. Vocational Education Program Courses Standards.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee. Div. of Vocational, Adult, and Community Education.

This document contains vocational education program courses standards (curriculum frameworks and student performance standards) for exploratory courses, practical arts courses, and job preparatory programs in technology education offered at the secondary or postsecondary level as a part of Florida's comprehensive vocational education program.…

Public Service Education. Vocational Education Program Courses Standards.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee. Div. of Vocational, Adult, and Community Education.

This document contains vocational education program courses standards (curriculum frameworks and student performance standards) for exploratory courses, practical arts courses, and job preparatory programs in public service education offered at the secondary or postsecondary level as a part of Florida's comprehensive vocational education program.…

Program Helps Standardize Documentation Of Software

NASA Technical Reports Server (NTRS)

Howe, G.

1994-01-01

Intelligent Documentation Management System, IDMS, computer program developed to assist project managers in implementing information system documentation standard known as NASA-STD-2100-91, NASA STD, COS-10300, of NASA's Software Management and Assurance Program. Standard consists of data-item descriptions or templates, each of which governs particular component of software documentation. IDMS helps program manager in tailoring documentation standard to project. Written in C language.

Perspectives in Peer Programs. Volume 28, Number 1, Winter 2018

ERIC Educational Resources Information Center

Tindall, Judith, Ed.; Black, David R., Ed.; Routson, Sue, Ed.

2018-01-01

This issue of "Perspectives in Peer Programs," the official journal of the National Association of Peer Program Professionals (NAPP), includes: (1) Introduction to this Issue on NAPPP Programmatic Standards Checklist, Programmatic Standards, Ethics, and Rubric; (2) NAPPP Programmatic Standards Checklist; (3) NAPPP Programmatic Standards;…

Manual of Accreditation Standards for Adventure Programs 1995.

ERIC Educational Resources Information Center

Williamson, John E., Comp.; Gass, Michael, Comp.

This manual presents standards for adventure education programs seeking accreditation from the Association for Experiential Education. The manual is set up sequentially, focusing both on objective standards such as technical risk management aspects, and on subjective standards such as teaching approaches used in programs. Chapter titles provide…

Standards for Agricultural Occupations Programs in Illinois Community Colleges. Interim Report of the Community College Phase [Phase I] of Project RD1-A8-564 Entitled "Standards for Illinois ABAO Post-Secondary Programs and Secondary Programs in Cook County".

ERIC Educational Resources Information Center

Walker, Robert W.; Hemp, Paul E.

A study was made of Phase 1 of the long-term standards program for agricultural occupations programs for Illinois community colleges. The unique feature of this project was the procedure used to maximize the input of community college teachers in the validation and revision of the national standards. Survey instruments were sent to community…

Standards Participation Guidance : ITS Standards Program

DOT National Transportation Integrated Search

2018-04-15

The Intelligent Transportation System Joint Program Office (ITS JPO) focuses on research projects, exploratory studies and deployment support for the intelligent transportation system. The ITS Architecture and Standards Programs are foundational to t...

Development of Standards for Textiles and Clothing Postsecondary Programs. Final Report.

ERIC Educational Resources Information Center

Iowa State Univ. of Science and Technology, Ames. Dept. of Home Economics Education.

A project was conducted to validate program standards and performance standards for four postsecondary occupational areas--fashion merchandising, fashion design, apparel, and window treatment services. Returns from 117 questionnaires from postsecondary institutions in fifty states were used to develop program standards statements and to provide…

Automotive Technology Skill Standards

ERIC Educational Resources Information Center

Garrett, Tom; Asay, Don; Evans, Richard; Barbie, Bill; Herdener, John; Teague, Todd; Allen, Scott; Benshoof, James

2009-01-01

The standards in this document are for Automotive Technology programs and are designed to clearly state what the student should know and be able to do upon completion of an advanced high-school automotive program. Minimally, the student will complete a three-year program to achieve all standards. Although these exit-level standards are designed…

Computer Programs for the Semantic Differential: Further Modifications.

ERIC Educational Resources Information Center

Lawson, Edwin D.; And Others

The original nine programs for semantic differential analysis have been condensed into three programs which have been further refined and augmented. They yield: (1) means, standard deviations, and standard errors for each subscale on each concept; (2) Evaluation, Potency, and Activity (EPA) means, standard deviations, and standard errors; (3)…

24 CFR 200.948 - Building product standards and certification program for carpet cushion.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Minimum Property Standards § 200.948 Building product standards and certification program for carpet... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Building product standards and certification program for carpet cushion. 200.948 Section 200.948 Housing and Urban Development Regulations...

7 CFR 1726.304 - List of electric program standard contract forms.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false List of electric program standard contract forms... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES RUS Standard Forms § 1726.304 List of electric program standard contract forms. (a) General. This section...

Relationship between internal medicine program board examination pass rates, accreditation standards, and program size.

PubMed

Falcone, John L; Gonzalo, Jed D

2014-01-19

To determine Internal Medicine residency program compliance with the Accreditation Council for Graduate Medical Education 80% pass-rate standard and the correlation between residency program size and performance on the American Board of Internal Medicine Certifying Examination. Using a cross-sectional study design from 2010-2012 American Board of Internal Medicine Certifying Examination data of all Internal Medicine residency pro-grams, comparisons were made between program pass rates to the Accreditation Council for Graduate Medical Education pass-rate standard. To assess the correlation between program size and performance, a Spearman's rho was calculated. To evaluate program size and its relationship to the pass-rate standard, receiver operative characteristic curves were calculated. Of 372 Internal Medicine residency programs, 276 programs (74%) achieved a pass rate of =80%, surpassing the Accreditation Council for Graduate Medical Education minimum standard. A weak correlation was found between residency program size and pass rate for the three-year period (p=0.19, p<0.001). The area underneath the receiver operative characteristic curve was 0.69 (95% Confidence Interval [0.63-0.75]), suggesting programs with less than 12 examinees/year are less likely to meet the minimum Accreditation Council for Graduate Medical Education pass-rate standard (sensitivity 63.8%, specificity 60.4%, positive predictive value 82.2%, p<0.001). Although a majority of Internal Medicine residency programs complied with Accreditation Council for Graduate Medical Education pass-rate standards, a quarter of the programs failed to meet this requirement. Program size is positively but weakly associated with American Board of Internal Medicine Certifying Examination performance, suggesting other unidentified variables significantly contribute to program performance.

Avionics Maintenance Technology Program Standards.

ERIC Educational Resources Information Center

Georgia Univ., Athens. Dept. of Vocational Education.

This publication contains statewide standards for the avionics maintenance technology program in Georgia. The standards are divided into the following categories: foundations, diploma/degree (philosophy, purpose, goals, program objectives, availability, evaluation); admissions, diploma/degree (admission requirements, provisional admission…

Radiologic Technology Program Standards.

ERIC Educational Resources Information Center

Georgia Univ., Athens. Dept. of Vocational Education.

This publication contains statewide standards for the radiologic technology program in Georgia. The standards are divided into 12 categories; Foundations (philosophy, purpose, goals, program objectives, availability, evaluation); Admissions (admission requirements, provisional admission requirements, recruitment, evaluation and planning); Program…

NAGC Pre-K-Grade 12 Gifted Education Programming Standards: A Guide to Planning and Implementing High-Quality Services

ERIC Educational Resources Information Center

Johnsen, Susan K., Ed.

2012-01-01

The new Pre-K-Grade 12 Gifted Education Programming Standards should be part of every school district's repertoire of standards to ensure that the learning needs of advanced students are being met. "NAGC Pre-K-Grade 12 Gifted Education Programming Standards: A Guide to Planning and Implementing High-Quality Services" details six standards that…

76 FR 17159 - Office of New Reactors; Final Interim Staff Guidance on Standard Review Plan, Section 17.4...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-28

... Interim Staff Guidance on Standard Review Plan, Section 17.4, ``Reliability Assurance Program'' AGENCY... design reliability assurance program (RAP). This ISG updates the guidance provided to the staff in Standard Review Plan (SRP), Section 17.4, ``Reliability Assurance Program,'' of NUREG-0800, ``Standard...

Applying your corporate compliance skills to the HIPAA security standard.

PubMed

Carter, P I

2000-01-01

Compliance programs are an increasingly hot topic among healthcare providers. These programs establish policies and procedures covering billing, referrals, gifts, confidentiality of patient records, and many other areas. The purpose is to help providers prevent and detect violations of the law. These programs are voluntary, but are also simply good business practice. Any compliance program should now incorporate the Health Insurance Portability and Accountability Act (HIPAA) security standard. Several sets of guidelines for development of compliance programs have been issued by the federal government, and each is directed toward a different type of healthcare provider. These guidelines share certain key features with the HIPAA security standard. This article examines the common areas between compliance programs and the HIPAA security standard to help you to do two very important things: (1) Leverage your resources by combining compliance with the security standard with other legal and regulatory compliance efforts, and (2) apply the lessons learned in developing your corporate compliance program to developing strategies for compliance with the HIPAA security standard.

Louisiana Standards for Programs Serving Four-Year-Old Children: Bulletin.

ERIC Educational Resources Information Center

Picard, Cecil J.

As part of Louisiana's efforts to expand and improve the quality of its early childhood programs, a committee of educators from across the state collaborated to develop standards for programs serving 4-year-olds. This guide presents program standards to assist the ongoing development, evaluation, and improvement of early childhood center-based…

25 CFR 36.40 - Standard XIII-Library/media program.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Standard XIII-Library/media program. 36.40 Section 36.40... § 36.40 Standard XIII—Library/media program. (a) Each school shall provide a library/media program... objectives have been met. (2) A written policy for the selection of materials and equipment shall be...

25 CFR 36.40 - Standard XIII-Library/media program.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 1 2012-04-01 2011-04-01 true Standard XIII-Library/media program. 36.40 Section 36.40... § 36.40 Standard XIII—Library/media program. (a) Each school shall provide a library/media program... developed by a library committee in collaboration with the librarian and be approved by the school board...

25 CFR 36.40 - Standard XIII-Library/media program.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false Standard XIII-Library/media program. 36.40 Section 36.40... § 36.40 Standard XIII—Library/media program. (a) Each school shall provide a library/media program... developed by a library committee in collaboration with the librarian and be approved by the school board...

25 CFR 36.40 - Standard XIII-Library/media program.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false Standard XIII-Library/media program. 36.40 Section 36.40... § 36.40 Standard XIII—Library/media program. (a) Each school shall provide a library/media program... developed by a library committee in collaboration with the librarian and be approved by the school board...

Comparison of Test Procedures and Energy Efficiency Criteria in Selected International Standards and Labeling Programs for Clothes Washers, Water Dispensers, Vending Machines and CFLs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fridley, David; Zheng, Nina; Zhou, Nan

Since the late 1970s, energy labeling programs and mandatory energy performance standards have been used in many different countries to improve the efficiency levels of major residential and commercial equipment. As more countries and regions launch programs covering a greater range of products that are traded worldwide, greater attention has been given to harmonizing the specific efficiency criteria in these programs and the test methods for measurements. For example, an international compact fluorescent light (CFL) harmonization initiative was launched in 2006 to focus on collaboration between Australia, China, Europe and North America. Given the long history of standards and labelingmore » programs, most major energy-consuming residential appliances and commercial equipment are already covered under minimum energy performance standards (MEPS) and/or energy labels. For these products, such as clothes washers and CFLs, harmonization may still be possible when national MEPS or labeling thresholds are revised. Greater opportunity for harmonization exists in newer energy-consuming products that are not commonly regulated but are under consideration for new standards and labeling programs. This may include commercial products such as water dispensers and vending machines, which are only covered by MEPS or energy labels in a few countries or regions. As China continues to expand its appliance standards and labeling programs and revise existing standards and labels, it is important to learn from recent international experiences with efficiency criteria and test procedures for the same products. Specifically, various types of standards and labeling programs already exist in North America, Europe and throughout Asia for products in China's 2010 standards and labeling programs, namely clothes washers, water dispensers, vending machines and CFLs. This report thus examines similarities and critical differences in energy efficiency values, test procedure specifications and other technical performance requirements in existing international programs in order to shed light on where Chinese programs currently stands and considerations for their 2010 programs.« less

NASA space station software standards issues

NASA Technical Reports Server (NTRS)

Tice, G. D., Jr.

1985-01-01

The selection and application of software standards present the NASA Space Station Program with the opportunity to serve as a pacesetter for the United States software in the area of software standards. The strengths and weaknesses of each of the NASA defined software standards issues are summerized and discussed. Several significant standards issues are offered for NASA consideration. A challenge is presented for the NASA Space Station Program to serve as a pacesetter for the U.S. Software Industry through: (1) Management commitment to software standards; (2) Overall program participation in software standards; and (3) Employment of the best available technology to support software standards

Hospitality and Tourism Education Skill Standards: Grade 12

ERIC Educational Resources Information Center

Underwood, Ryan; Spann, Lynda; Erickson, Karin; Povilaitis, Judy; Menditto, Louis; Jones, Terri; Sario, Vivienne; Verbeck, Kimberlee; Jacobi, Katherine; Michnal, Kenneth; Shelton-Meader, Sheree; Richens, Greg; Jones, Karin Erickson; Tighe, Denise; Wilhelm, Lee; Scott, Melissa

2010-01-01

The standards in this document are for Hospitality and Tourism programs and are designed to clearly state what the student should know and be able to do upon completion of an advanced high-school program. Minimally, the student will complete a two-year program to achieve all standards. The Hospitality and Tourism Standards Writing Team followed…

NIST Mechanisms for Disseminating Measurements

PubMed Central

Gills, T. E.; Dittman, S.; Rumble, J. R.; Brickenkamp, C. S.; Harris, G. L.; Trahey, N. M.

2001-01-01

The national responsibilities assigned to the National Bureau of Standards (NBS) early in the last century for providing measurement assistance and service are carried out today by the four programs that comprise the National Institute of Standards and Technology (NIST) Office of Measurement Services (OMS). They are the Calibration Program (CP), the Standard Reference Materials Program (SRMP), the Standard Reference Data Program (SRDP), and the Weights and Measures Program (W&MP). Organized when the U.S. Congress changed the NBS name to NIST, the OMS facilitates access to the measurement and standards activities of NIST laboratories and programs through the dissemination of NIST products, data, and services. A brief historical introduction followed by a perspective of pivotal measurement developments from 1901 to the present and concluding with a look to the future of NIST measurement services in the next decade of the new millennium are presented for each OMS program. PMID:27500025

Business Technology Education. Vocational Education Program Courses Standards.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee. Div. of Applied Tech., Adult, and Community Education.

This document contains vocational education program course standards (curriculum frameworks and student performance standards) for exploratory courses, practical arts courses, and job preparatory programs offered at the secondary and postsecondary level as part of the business technology education component of Florida's comprehensive vocational…

Marketing Education. Vocational Education Program Courses Standards.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee. Div. of Applied Tech., Adult, and Community Education.

This document contains vocational education program course standards (curriculum frameworks and student performance standards) for exploratory courses, practical arts courses, and job preparatory programs offered at the secondary and postsecondary level as part of the marketing education component of Florida's comprehensive vocational education…

Health Science Education. Vocational Education Program Courses Standards.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee. Div. of Applied Tech., Adult, and Community Education.

This document contains vocational education program course standards (curriculum frameworks and student performance standards) for exploratory courses, practical arts courses, and job preparatory programs offered at the secondary and postsecondary level as part of the health science education component of Florida's comprehensive vocational…

75 FR 10843 - Special Summer Postal Rate Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-09

..., Pricing Strategy, as the official available to provide prompt responses to requests for clarification from... special volume pricing incentive for certain Standard Mail this summer. This document announces... Standard Mail Volume Incentive Pricing Program (Standard Mail Incentive Program) similar to the one...

Public Service Education. Vocational Education Program Courses Standards.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee. Div. of Applied Tech., Adult, and Community Education.

This document contains vocational education program course standards (curriculum frameworks and student performance standards) for exploratory courses, practical arts courses, and job preparatory programs offered at the secondary and postsecondary level as part of the public service education component of Florida's comprehensive vocational…

Technology Education. Vocational Education Program Courses Standards.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee. Div. of Applied Tech., Adult, and Community Education.

This document contains vocational education program course standards (curriculum frameworks and student performance standards) for exploratory courses, practical arts courses, and job preparatory programs offered at the secondary and postsecondary level as part of the technology education component of Florida's comprehensive vocational education…

Real-time system for extracting and monitoring the cerebral functional component during fNIRS measurements

NASA Astrophysics Data System (ADS)

Yamada, Toru; Ohashi, Mitsuo; Umeyama, Shinji

2015-12-01

Functional near-infrared spectroscopy (fNIRS) can non-invasively detect hemodynamic changes associated with cerebral neural activation in human subjects. However, its signal is often affected by changes in the optical characteristics of tissues in the head other than brain. To conduct fNIRS measurements precisely and efficiently, the extraction and realtime monitoring of the cerebral functional component is crucial. We previously developed methods for extracting the cerebral functional component—the multidistance optode arrangement (MD) method and the hemodynamic modality separation (HMS) method. In this study, we implemented these methods in a software used with the fNIRS system OEG- 17APD (Spectratech, Japan), and realized a real-time display of the extracted results. When using this system for human subject experiments, the baselines obtained with the MD and HMS methods were highly stabilized, whereas originally, the fNIRS signal fluctuated significantly when the subject moved. Through a functional experiment with repetitive single-sided hand clasping tasks, the extracted signals showed distinctively higher reproducibility than that obtained in the conventional measurements.

Kinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker Ase1 in fission yeast

PubMed Central

Rincon, Sergio A.; Lamson, Adam; Blackwell, Robert; Syrovatkina, Viktoriya; Fraisier, Vincent; Paoletti, Anne; Betterton, Meredith D.; Tran, Phong T.

2017-01-01

Bipolar spindle assembly requires a balance of forces where kinesin-5 produces outward pushing forces to antagonize the inward pulling forces from kinesin-14 or dynein. Accordingly, Kinesin-5 inactivation results in force imbalance leading to monopolar spindle and chromosome segregation failure. In fission yeast, force balance is restored when both kinesin-5 Cut7 and kinesin-14 Pkl1 are deleted, restoring spindle bipolarity. Here we show that the cut7Δpkl1Δ spindle is fully competent for chromosome segregation independently of motor activity, except for kinesin-6 Klp9, which is required for anaphase spindle elongation. We demonstrate that cut7Δpkl1Δ spindle bipolarity requires the microtubule antiparallel bundler PRC1/Ase1 to recruit CLASP/Cls1 to stabilize microtubules. Brownian dynamics-kinetic Monte Carlo simulations show that Ase1 and Cls1 activity are sufficient for initial bipolar spindle formation. We conclude that pushing forces generated by microtubule polymerization are sufficient to promote spindle pole separation and the assembly of bipolar spindle in the absence of molecular motors. PMID:28513584

USL/DBMS NASA/PC R and D project C programming standards

NASA Technical Reports Server (NTRS)

Dominick, Wayne D. (Editor); Moreau, Dennis R.

1984-01-01

A set of programming standards intended to promote reliability, readability, and portability of C programs written for PC research and development projects is established. These standards must be adhered to except where reasons for deviation are clearly identified and approved by the PC team. Any approved deviation from these standards must also be clearly documented in the pertinent source code.

Indicators of Program Quality, Measures of Performance & Standards. Adult Basic Education and ESL Programs in NJ. Summary Report.

ERIC Educational Resources Information Center

Merkel-Keller, Claudia; Streeter-Scrupski, Sandra

In 1992, adult education staff and adult literacy volunteer organizations developed 8 indicators of program quality to be used for evaluating adult basic education and English as a Second Language (ESL) programs in New Jersey. Performance standards were developed to match the standards. An evaluation was conducted to determine how the indicators…

NPRM: Head Start Program Performance Standards.

ERIC Educational Resources Information Center

Administration for Children, Youth, and Families (DHHS), Washington, DC. Head Start Bureau.

This document contains the Notice of Proposed Rulemaking (NPRM) on Head Start Program Performance Standards, appearing in the April 22, 1996 "Federal Register." The Administration for Children, Youth, and Families issued this notice to implement the statutory provisions for establishing program performance standards for early Head Start…

Health Occupations Education. Vocational Education Program Courses Standards.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee. Div. of Vocational, Adult, and Community Education.

This document contains vocational education program courses standards (curriculum frameworks and student performance standards) for exploratory courses, practical arts courses, and job preparatory programs in health occupations (HO) education offered at the secondary or postsecondary level as a part of Florida's comprehensive vocational education…

Common Standards for Career Education Programs

ERIC Educational Resources Information Center

Missouri Department of Elementary and Secondary Education, 2012

2012-01-01

The Office of College and Career Readiness has developed the "Common Standards for Career Education Programs." The six common standards are: (1) Program Management and Planning; (2) Curriculum; (3) Instruction; (4) Professional Development; (5) Career and Technical Student Organizations; and (6) Instructional Facilities and Equipment.…

42 CFR 423.160 - Standards for electronic prescribing.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Council for Prescription Drug Programs Prescriber/Pharmacist Interface SCRIPT Standard, Implementation... National Council for Prescription Drug Programs Prescriber/Pharmacist Interface SCRIPT Standard... Prescriber/Pharmacist Interface SCRIPT Standard, Implementation Guide Version 8, Release 1 (Version 8.1...

42 CFR 423.160 - Standards for electronic prescribing.

Code of Federal Regulations, 2013 CFR

2013-10-01

... National Council for Prescription Drug Programs Prescriber/Pharmacist Interface SCRIPT Standard... National Council for Prescription Drug Programs Prescriber/Pharmacist Interface SCRIPT Standard... Prescriber/Pharmacist Interface SCRIPT Standard, Implementation Guide Version 8, Release 1 (Version 8.1...

42 CFR 423.160 - Standards for electronic prescribing.

Code of Federal Regulations, 2014 CFR

2014-10-01

... National Council for Prescription Drug Programs Prescriber/Pharmacist Interface SCRIPT Standard... National Council for Prescription Drug Programs Prescriber/Pharmacist Interface SCRIPT Standard... Prescriber/Pharmacist Interface SCRIPT Standard, Implementation Guide Version 8, Release 1 (Version 8.1...

Family and Consumer Sciences Education. Vocational Education Program Courses Standards.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee. Div. of Applied Tech., Adult, and Community Education.

This document contains vocational education program course standards (curriculum frameworks and student performance standards) for exploratory courses, practical arts courses, and job preparatory programs offered at the secondary and postsecondary level as part of the family and consumer sciences component of Florida's comprehensive vocational…

Industrial Education. Vocational Education Program Courses Standards.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee. Div. of Vocational, Adult, and Community Education.

This document contains industrial education courses standards for 183 exploratory courses, practical arts courses, and job preparatory programs offered at the secondary or postsecondary level in Florida. Each program courses standard is composed of two parts. The first part, the curriculum framework, includes four major sections: major…

49 CFR 659.15 - System safety program standard.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 7 2010-10-01 2010-10-01 false System safety program standard. 659.15 Section 659... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAIL FIXED GUIDEWAY SYSTEMS; STATE SAFETY OVERSIGHT Role of the State Oversight Agency § 659.15 System safety program standard. (a) General requirement. Each state...

Agribusiness and Natural Resources Education. Vocational Education Program Courses Standards.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee. Div. of Applied Tech., Adult, and Community Education.

This document contains vocational education program course standards (curriculum frameworks and student performance standards) for exploratory courses, practical arts courses, and job preparatory programs offered at the secondary and postsecondary level as part of the agribusiness and natural resources education component of Florida's…

75 FR 17861 - 2010 Standard Mail Incentive Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-08

...The Postal Service is revising Mailing Standards of the United States Postal Service, Domestic Mail Manual (DMM[supreg]), to replace existing section 709.2 with new standards for a volume incentive program for mailers of Standard Mail[supreg] letters and flats with mail volume exceeding their individual USPS[supreg]--determined threshold levels. The program period will be from July 1, 2010 through September 30, 2010.

30 CFR 815.15 - Performance standards for coal exploration.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Performance standards for coal exploration. 815... OF THE INTERIOR PERMANENT PROGRAM PERFORMANCE STANDARDS PERMANENT PROGRAM PERFORMANCE STANDARDS-COAL EXPLORATION § 815.15 Performance standards for coal exploration. (a) Habitats of unique or unusually high...

30 CFR 815.15 - Performance standards for coal exploration.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Performance standards for coal exploration. 815... OF THE INTERIOR PERMANENT PROGRAM PERFORMANCE STANDARDS PERMANENT PROGRAM PERFORMANCE STANDARDS-COAL EXPLORATION § 815.15 Performance standards for coal exploration. (a) Habitats of unique or unusually high...

30 CFR 815.15 - Performance standards for coal exploration.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Performance standards for coal exploration. 815... OF THE INTERIOR PERMANENT PROGRAM PERFORMANCE STANDARDS PERMANENT PROGRAM PERFORMANCE STANDARDS-COAL EXPLORATION § 815.15 Performance standards for coal exploration. (a) Habitats of unique or unusually high...

30 CFR 815.15 - Performance standards for coal exploration.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Performance standards for coal exploration. 815... OF THE INTERIOR PERMANENT PROGRAM PERFORMANCE STANDARDS PERMANENT PROGRAM PERFORMANCE STANDARDS-COAL EXPLORATION § 815.15 Performance standards for coal exploration. (a) Habitats of unique or unusually high...

30 CFR 815.15 - Performance standards for coal exploration.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Performance standards for coal exploration. 815... OF THE INTERIOR PERMANENT PROGRAM PERFORMANCE STANDARDS PERMANENT PROGRAM PERFORMANCE STANDARDS-COAL EXPLORATION § 815.15 Performance standards for coal exploration. (a) Habitats of unique or unusually high...

20 CFR 627.470 - Performance standards.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Performance standards. 627.470 Section 627... GOVERNING PROGRAMS UNDER TITLES I, II, AND III OF THE ACT Administrative Standards § 627.470 Performance standards. (a) General. The Secretary shall prescribe performance standards for adult programs under title...

20 CFR 627.470 - Performance standards.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false Performance standards. 627.470 Section 627... GOVERNING PROGRAMS UNDER TITLES I, II, AND III OF THE ACT Administrative Standards § 627.470 Performance standards. (a) General. The Secretary shall prescribe performance standards for adult programs under title...

7 CFR 1724.74 - List of electric program standard contract forms.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 11 2014-01-01 2014-01-01 false List of electric program standard contract forms... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC ENGINEERING, ARCHITECTURAL SERVICES AND DESIGN POLICIES AND PROCEDURES RUS Contract Forms § 1724.74 List of electric program standard contract forms. (a...

7 CFR 1724.74 - List of electric program standard contract forms.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 11 2011-01-01 2011-01-01 false List of electric program standard contract forms... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC ENGINEERING, ARCHITECTURAL SERVICES AND DESIGN POLICIES AND PROCEDURES RUS Contract Forms § 1724.74 List of electric program standard contract forms. (a...

7 CFR 1724.74 - List of electric program standard contract forms.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 11 2013-01-01 2013-01-01 false List of electric program standard contract forms... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC ENGINEERING, ARCHITECTURAL SERVICES AND DESIGN POLICIES AND PROCEDURES RUS Contract Forms § 1724.74 List of electric program standard contract forms. (a...

7 CFR 1724.74 - List of electric program standard contract forms.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false List of electric program standard contract forms... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC ENGINEERING, ARCHITECTURAL SERVICES AND DESIGN POLICIES AND PROCEDURES RUS Contract Forms § 1724.74 List of electric program standard contract forms. (a...

7 CFR 1724.74 - List of electric program standard contract forms.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 11 2012-01-01 2012-01-01 false List of electric program standard contract forms... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC ENGINEERING, ARCHITECTURAL SERVICES AND DESIGN POLICIES AND PROCEDURES RUS Contract Forms § 1724.74 List of electric program standard contract forms. (a...

76 FR 22453 - Energy Conservation Program: Energy Conservation Standards for Residential Clothes Dryers and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-21

.... These impacts continue well beyond 2100. Table I-3 shows the annualized values for the clothes dryer... Conservation Program: Energy Conservation Standards for Residential Clothes Dryers and Room Air Conditioners... 1904-AA89 Energy Conservation Program: Energy Conservation Standards for Residential Clothes Dryers and...

Standards Based Reform. Abbott Implementation Resource Guide

ERIC Educational Resources Information Center

Passantino, Claire; Kenyon, Susan

2004-01-01

The goal of this guide is to provide information, support and practical tools that may help educators design, implement, and evaluate their school's standards-based education program. In order to work, a comprehensive, standards-based educational program must, by definition, be the organizing structure upon which the school program operates.…

Agribusiness & Natural Resources Education. Vocational Education Program Courses Standards.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee. Div. of Vocational, Adult, and Community Education.

This document contains agribusiness and natural resources education courses standards for 43 exploratory courses, practical arts courses, and job preparatory programs offered at the secondary or postsecondary level in Florida. Each program courses standard is composed of two parts. The first part, the curriculum framework, includes four major…

24 CFR 200.937 - Supplementary specific procedural requirements under HUD building product standards and...

Code of Federal Regulations, 2010 CFR

2010-04-01

... requirements under HUD building product standards and certification program for plastic bathtub units, plastic... procedural requirements under HUD building product standards and certification program for plastic bathtub... product certification program. In the case of plastic bathroom fixtures, testing and inspection shall be...

Standards for Implementing Quality Prekindergarten Education.

ERIC Educational Resources Information Center

Maryland State Dept. of Education, Baltimore. Div. of Instruction.

These standards are provided to promote the achievement of excellence in Maryland's public school prekindergarten programs. To that end, this document delineates standards of quality and provides a list of indicators that concretely describe what a program will look like if the standards are being met. The standards and indicators address seven…

ANOPP programming and documentation standards document

NASA Technical Reports Server (NTRS)

1976-01-01

Standards defining the requirements for preparing software for the Aircraft Noise Prediction Program (ANOPP) were given. It is the intent of these standards to provide definition, design, coding, and documentation criteria for the achievement of a unity among ANOPP products. These standards apply to all of ANOPP's standard software system. The standards encompass philosophy as well as techniques and conventions.

Standards 101; the ASA standards program

NASA Astrophysics Data System (ADS)

Schomer, Paul D.

2002-11-01

ASA supports the development of standards by serving as the secretariat for standards committees of the American National Standards Institute (ANSI). The program is organized through four ANSI technical committees (S1, S2, S3, and S12) and one administrative committee (ASACOS). S1 deals with physical acoustics, S2 deals with shock and vibration, S3 deals with physiological and psychological acoustics, and S12 deals with noise. ASACOS is the ASA Committee on Standards. The program has three primary tasks: (1) the development of National Standards (ANSI Standards), (2) the national adoption of an international standard (ANSI NAIS Standards), (3) providing the USA input to the development of International Standards (ISO and IEC Standards). At every level the main work is accomplished in Working Groups (WG) that are ''staffed'' by hundreds of volunteers--mainly ASA members from its various technical committees such as Noise, Physical Acoustics, Architectural Acoustics, Psychological and Physiological Acoustics, etc. Overall, the Standards Program involves more ASA members than does any other single function of the Society except meetings and it is the biggest outreach function of ASA affecting the health, welfare, and economic well-being of large segments of the population, the business and industrial community, and government at all levels.

Standards 101: The ASA Standards program

NASA Astrophysics Data System (ADS)

Schomer, Paul

2004-05-01

ASA serves as a standards developer under the auspices of the American National Standards Institute (ANSI). The Standards Program is organized through four technical committees (S1, S2, S3, and S12) and one administrative committee (ASACOS). S1 deals with physical acoustics, S2 deals with shock and vibration, S3 deals with physiological and psychological acoustics and S12 deals with noise. ASACOS is the ASA Committee on Standards. The program has three primary tasks: (1) development of national standards (ANSI Standards), (2) national adoption of international standards (ANSI NAIS Standards), (3) providing the USA input to the development of international standards (ISO and IEC Standards). At every level the main work is accomplished in Working Groups (WG) that are staffed by hundreds of volunteers, mainly ASA members from its various technical committees such as Noise, Physical Acoustics, Architectural Acoustics, Physiological and Psychological Acoustics, etc. Overall, the Standards Program involves more ASA members than does any other single function of the society except meetings. It is the biggest outreach function of ASA affecting the health, welfare, and economic well-being of large sectors of society. It is a main way the ASA diffuses the knowledge of acoustics and its practical application, perhaps the main way.

Stiffness and force in activated frog skeletal muscle fibers.

PubMed Central

Cecchi, G.; Griffiths, P. J.; Taylor, S.

1986-01-01

Single fibers, isolated intact from frog skeletal muscles, were held firmly very near to each end by stiff metal clasps fastened to the tendons. The fibers were then placed horizontally between two steel hooks inserted in eyelets of the tendon clasps. One hook was attached to a capacitance gauge force transducer (resonance frequency up to approximately 50 kHz) and the other was attached to a moving-coil length changer. This allowed us to impose small, rapid releases (complete in less than 0.15 ms) and high frequency oscillations (up to 13 kHz) to one end of a resting or contracting fiber and measure the consequences at the other end with fast time resolution at 4 to 6 degrees C. The stiffness of short fibers (1.8-2.6 mm) was determined directly from the ratio of force to length variations produced by the length changer. The resonance frequency of short fibers was so high (approximately 40 kHz) that intrinsic oscillations were not detectably excited. The stiffness of long fibers, on the other hand, was calculated from measurement of the mechanical resonance frequency of a fiber. Using both short and long fibers, we measured the sinusoids of force at one end of a contracting fiber that were produced by relatively small sinusoidal length changes at the other end. The amplitudes of the sinusoidal length changes were small compared with the size of step changes that produce nonlinear force-extension relations. The sinusoids of force from long fibers changed amplitude and shifted phase with changes in oscillation frequency in a manner expected of a transmission line composed of mass, compliance, and viscosity, similar to that modelled by (Ford, L. E., A. F. Huxley, and R. M. Simmons, 1981, J. Physiol. (Lond.), 311:219-249). A rapid release during the plateau of tetanic tension in short fibers caused a fall in force and stiffness, a relative change in stiffness that putatively was much smaller than that of force. Our results are, for the most part, consistent with the cross-bridge model of force generation proposed by Huxley, A. F., and R. M. Simmons (1971, Nature (Lond.), 213:533-538). However, stiffness in short fibers developed markedly faster than force during the tetanus rise. Thus our findings show the presence of one or more noteworthy cross-bridge states at the onset and during the rise of active tension towards a plateau in that attachment apparently is followed by a relatively long delay before force generation occurs. A set of equations is given in the Appendix that describes the frequency dependence of the applied sinusoid and its response. This model predicts that frequency dependent changes can be used as a measure of a change in stiffness. PMID:3955178

A study of science leadership and science standards in exemplary standards-based science programs

NASA Astrophysics Data System (ADS)

Carpenter, Wendy Renae

The purpose for conducting this qualitative study was to explore best practices of exemplary standards-based science programs and instructional leadership practices in a charter high school and in a traditional high school. The focus of this study included how twelve participants aligned practices to National Science Education Standards to describe their science programs and science instructional practices. This study used a multi-site case study qualitative design. Data were obtained through a review of literature, interviews, observations, review of educational documents, and researcher's notes collected in a field log. The methodology used was a multi-site case study because of the potential, through cross analysis, for providing greater explanation of the findings in the study (Merriam, 1988). This study discovered six characteristics about the two high school's science programs that enhance the literature found in the National Science Education Standards; (a) Culture of expectations for learning-In exemplary science programs teachers are familiar with a wide range of curricula. They have the ability to examine critically and select activities to use with their students to promote the understanding of science; (b) Culture of varied experiences-In exemplary science programs students are provided different paths to learning, which help students, take in information and make sense of concepts and skills that are set forth by the standards; (c) Culture of continuous feedback-In exemplary science programs teachers and students work together to engage students in ongoing assessments of their work and that of others as prescribed in the standards; (d) Culture of Observations-In exemplary science programs students, teachers, and principals reflect on classroom instructional practices; teachers receive ongoing evaluations about their teaching and apply feedback towards improving practices as outlined in the standards; (e) Culture of continuous learning-In exemplary science programs teachers value continuous personal development, teachers are provided on-going science professional development opportunities to improve instructional practices, teachers reflect and share professional practices, and teachers establish professional learning communities within their classrooms; and (f) Culture of shared leadership-In exemplary science programs instructional leadership purposes and values are consistently shared among all stakeholders which are outlined in the standards. These results are potentially useful for understanding exemplary standards-based science programs and science instructional leadership practices as a model for science programs trying to improve science education so that all students can have a true scientific learning experience.

ASE Program Certification Standards for Automobile Technician Training Programs.

ERIC Educational Resources Information Center

National Automotive Technicians Education Foundation, Herndon, VA.

This document presents and explains the development and application of the National Institute for Automotive Service Excellence (ASE) program certification standards that were developed to improve the quality of secondary- and postsecondary-level automobile technician training by implementing a certification program that certifies programs in…

Cartographic standards to improve maps produced by the Forest Inventory and Analysis program

Treesearch

Charles H. (Hobie) Perry; Mark D. Nelson

2009-01-01

The Forest Service, U.S. Department of Agriculture's Forest Inventory and Analysis (FIA) program is incorporating an increasing number of cartographic products in reports, publications, and presentations. To create greater quality and consistency within the national FIA program, a Geospatial Standards team developed cartographic design standards for FIA map...

24 CFR 200.949 - Building product standards and certification program for exterior insulated steel door systems.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Doors and Frames; (viii) ISDSI-107-80—Thermal Performance Standard for Insulated Steel Door Systems; (ix... certification program for exterior insulated steel door systems. 200.949 Section 200.949 Housing and Urban... program for exterior insulated steel door systems. (a) Applicable standards. (1) All Exterior Insulated...

25 CFR 36.12 - Standard III-Program needs assessment.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false Standard III-Program needs assessment. 36.12 Section 36... Management § 36.12 Standard III—Program needs assessment. The policy and procedures of each school and its curricula shall be developed and revised based on an assessment of educational needs. This needs assessment...

25 CFR 36.12 - Standard III-Program needs assessment.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 1 2012-04-01 2011-04-01 true Standard III-Program needs assessment. 36.12 Section 36.12... § 36.12 Standard III—Program needs assessment. The policy and procedures of each school and its curricula shall be developed and revised based on an assessment of educational needs. This needs assessment...

25 CFR 36.12 - Standard III-Program needs assessment.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false Standard III-Program needs assessment. 36.12 Section 36... Management § 36.12 Standard III—Program needs assessment. The policy and procedures of each school and its curricula shall be developed and revised based on an assessment of educational needs. This needs assessment...

25 CFR 36.12 - Standard III-Program needs assessment.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false Standard III-Program needs assessment. 36.12 Section 36... Management § 36.12 Standard III—Program needs assessment. The policy and procedures of each school and its curricula shall be developed and revised based on an assessment of educational needs. This needs assessment...

State Skill Standards: Furniture and Cabinetmaking

ERIC Educational Resources Information Center

Evans, Ronald; Varischetti, Barry; Alvey, Raymond; Volberding, Le; McCabe, Dave; Sanchez, Fernando; Wright, Russell

2006-01-01

The Department of Education is continuing the development of statewide skill standards for all career and technical education programs. The standards in this document are for Furniture and Cabinetmaking programs and are designed to clearly state what the student should know and be able to do upon completion of an advanced high-school program. The…

25 CFR 36.51 - Standard XVIII-Office of Indian Education Programs and Agency monitoring and evaluation...

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Standard XVIII-Office of Indian Education Programs and..., DEPARTMENT OF THE INTERIOR EDUCATION MINIMUM ACADEMIC STANDARDS FOR THE BASIC EDUCATION OF INDIAN CHILDREN... XVIII—Office of Indian Education Programs and Agency monitoring and evaluation responsibilities. (a) The...

Grant Activities for U.S. Department of Education Business & Education Standards Program. Final Report.

ERIC Educational Resources Information Center

National Automotive Technicians Education Foundation, Herndon, VA.

A project was conducted by the National Automotive Technicians Education Foundation to review and update the standards for automobile, collision repair and refinishing, and medium and heavy truck technician training programs. The standards include a task list, tools and equipment requirements, program hour requirements, instructor qualifications,…

NASA Technical Standards Program and Implications for Lessons Learned and Technical Standard Integration

NASA Technical Reports Server (NTRS)

Gill, Paul S.; Garcia, Danny; Vaughan, William W.; Parker, Nelson C. (Technical Monitor)

2002-01-01

The National Aeronautics and Space Agency consists of fourteen Facilities throughout the United States. They are organized to support the Agency's principal Enterprises: (1) Space Science, (2) Earth Science, (3) Aerospace Technology, (4) Human Exploration and Development of Space, and (5) Biological and Physical Research. Technical Standards are important to the activities of each Enterprise and have been an integral part in the development and operation of NASA Programs and Projects since the Agency was established in 1959. However, for years each Center was responsible for its own standards development and selection of non-NASA technical standards that met the needs of Programs and Projects for which they were responsible. There were few Agencywide applicable Technical Standards, mainly those in area of safety. Department of Defense Standards and Specifications were the foundation and main source for Technical Standards used by the Agency. This process existed until about 1997 when NASA embarked on a Program to convert NASA's Center-developed Technical Standards into Agencywide endorsed NASA Preferred Technical Standards. In addition, action was taken regarding the formal adoption of non-NASA Technical Standards (DOD, SAE, ASTM, ASME, IEEE, etc.) as NASA Preferred Technical Standards.

24 CFR 200.949 - Building product standards and certification program for exterior insulated steel door systems.

Code of Federal Regulations, 2010 CFR

2010-04-01

... INTRODUCTION TO FHA PROGRAMS Minimum Property Standards § 200.949 Building product standards and certification... product, the administrator's certification of compliance with the applicable standards is required to be... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Building product standards and...

24 CFR 200.947 - Building product standards and certification program for polystyrene foam insulation board.

Code of Federal Regulations, 2010 CFR

2010-04-01

... INTRODUCTION TO FHA PROGRAMS Minimum Property Standards § 200.947 Building product standards and certification... product, the administrator's certification of compliance with the applicable standards and the type of... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Building product standards and...

24 CFR 200.949 - Building product standards and certification program for exterior insulated steel door systems.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Mass Applications; (ii) ISDSI-100-90—Door Size Dimensional Standard and Assembly Tolerances for... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Building product standards and... INTRODUCTION TO FHA PROGRAMS Minimum Property Standards § 200.949 Building product standards and certification...

User's guide for LTGSTD24 program, Version 2. 4

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hanlon, R.L.; Connell, L.M.

1993-05-01

On January 30, 1989, the US Department of Energy (DOE) promulgated an interim rule entitled [open quotes]Energy Conservation Voluntary Performance Standards for New Commercial and Multi-Family High Rise Residential Buildings; Mandatory for New Federal Buildings[close quotes] (10 CFR Part 435, Subpart A). These standards require federal agencies to design all future federal commercial and multifamily high-rise residential buildings in accordance with the standards, or demonstrate that their current requirements already meet or exceed the energy-efficiency requirements of the standards. Although these newly enacted standards do not regulate the design of non-federal buildings, the DOE recommends that all design professionals usemore » the standards as guidelines for designing energy-conserving buildings. To encourage private sector use, the DOE published the standards in the January 30, 1989, Federal Register in the format typical of commercial standards. The Pacific Northwest Laboratory developed several computer programs for the DOE to make it easier for designers to comply with the standards. One of the programs, LTGSTD24 (Version 2.4), is detailed in this user's guide and is provided on the accompanying diskettes. The program will facilitate the designer's use of the standards dealing specifically with building lighting design. Using this program will greatly simplify the designer's task of performing the calculations needed to determine if a design complies with the standards.« less

14 CFR 151.71 - Applicability.

Code of Federal Regulations, 2014 CFR

2014-01-01

... FEDERAL AID TO AIRPORTS Project Programming Standards § 151.71 Applicability. (a) This subpart prescribes programming and design and construction standards for projects under the Federal-Aid Airport Program to assure...

14 CFR 151.71 - Applicability.

Code of Federal Regulations, 2012 CFR

2012-01-01

... FEDERAL AID TO AIRPORTS Project Programming Standards § 151.71 Applicability. (a) This subpart prescribes programming and design and construction standards for projects under the Federal-Aid Airport Program to assure...

14 CFR 151.71 - Applicability.

Code of Federal Regulations, 2013 CFR

2013-01-01

... FEDERAL AID TO AIRPORTS Project Programming Standards § 151.71 Applicability. (a) This subpart prescribes programming and design and construction standards for projects under the Federal-Aid Airport Program to assure...

20 CFR 632.260 - Worksite standards.

Code of Federal Regulations, 2010 CFR

2010-04-01

... EMPLOYMENT AND TRAINING PROGRAMS Summer Youth Employment and Training Programs § 632.260 Worksite standards... rules and regulations governig the summer program. (2) Such written agreements may be memoranda of...

20 CFR 632.260 - Worksite standards.

Code of Federal Regulations, 2011 CFR

2011-04-01

... EMPLOYMENT AND TRAINING PROGRAMS Summer Youth Employment and Training Programs § 632.260 Worksite standards... rules and regulations governig the summer program. (2) Such written agreements may be memoranda of...

20 CFR 632.260 - Worksite standards.

Code of Federal Regulations, 2012 CFR

2012-04-01

... EMPLOYMENT AND TRAINING PROGRAMS Summer Youth Employment and Training Programs § 632.260 Worksite standards... rules and regulations governig the summer program. (2) Such written agreements may be memoranda of...

14 CFR 151.71 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-01-01

... FEDERAL AID TO AIRPORTS Project Programming Standards § 151.71 Applicability. (a) This subpart prescribes programming and design and construction standards for projects under the Federal-Aid Airport Program to assure...

14 CFR 151.71 - Applicability.

Code of Federal Regulations, 2011 CFR

2011-01-01

... FEDERAL AID TO AIRPORTS Project Programming Standards § 151.71 Applicability. (a) This subpart prescribes programming and design and construction standards for projects under the Federal-Aid Airport Program to assure...

Pass rates on the American Board of Family Medicine Certification Exam by residency location and size.

PubMed

Falcone, John L; Middleton, Donald B

2013-01-01

The Accreditation Council for Graduate Medical Education (ACGME) sets residency performance standards for the American Board of Family Medicine Certification Examination. This study aims are to describe the compliance of residency programs with ACGME standards and to determine whether residency pass rates depend on program size and location. In this retrospective cohort study, residency performance from 2007 to 2011 was compared with the ACGME performance standards. Simple linear regression was performed to see whether program pass rates were dependent on program size. Regional differences in performance were compared with χ(2) tests, using an α level of 0.05. Of 429 total residency programs, there were 205 (47.8%) that violate ACGME performance standards. Linear regression showed that program pass rates were positively correlated and dependent on program size (P < .001). The median pass rate per state was 86.4% (interquartile range, 82.0-90.8. χ(2) Tests showed that states in the West performed higher than the other 3 US Census Bureau Regions (all P < .001). Approximately half of the family medicine training programs do not meet the ACGME examination performance standards. Pass rates are associated with residency program size, and regional variation occurs. These findings have the potential to affect ACGME policy and residency program application patterns.

Day treatment versus enhanced standard methadone services for opioid-dependent patients: a comparison of clinical efficacy and cost.

PubMed

Avants, S K; Margolin, A; Sindelar, J L; Rounsaville, B J; Schottenfeld, R; Stine, S; Cooney, N L; Rosenheck, R A; Li, S H; Kosten, T R

1999-01-01

This study examined the differential efficacy and relative costs of two intensities of adjunctive psychosocial services--a day treatment program and enhanced standard care--for the treatment of opioid-dependent patients maintained on methadone hydrochloride. A 12-week randomized clinical trial with 6-month follow-up was conducted in a community-based methadone maintenance program. Of the 308 patients who met inclusion criteria, 291 began treatment (day treatment program: N=145; enhanced standard care: N=146), and 237 completed treatment (82% of those assigned to the day treatment program and 81% of those receiving enhanced standard care). Two hundred twenty of the patients participated in the 6-month follow-up (75% of those in the day treatment program and 73% of those in enhanced standard care provided a follow-up urine sample for screening). Both interventions were 12 weeks in duration, manual-guided, and provided by master's-level clinicians. The day treatment was an intensive, 25-hour-per-week program. The enhanced standard care was standard methadone maintenance plus a weekly skills training group and referral to on- and off-site services. Outcome measures included twice weekly urine toxicology screens, severity of addiction-related problems, prevalence of HIV risk behaviors, and program costs. Although the cost of the day treatment program was significantly higher, there was no significant difference in the two groups' use of either opiates or cocaine. Over the course of treatment, drug use, drug-related problems, and HIV risk behaviors decreased significantly for patients assigned to both treatment intensities. Improvements were maintained at follow-up. Providing an intensive day treatment program to unemployed, inner-city methadone patients was not cost-effective relative to a program of enhanced methadone maintenance services, which produced comparable outcomes at less than half the cost.

International Review of the Development and Implementation of Energy Efficiency Standards and Labeling Programs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhou, Nan; Zheng, Nina; Fridley, David

2012-02-28

Appliance energy efficiency standards and labeling (S&L) programs have been important policy tools for regulating the efficiency of energy-using products for over 40 years and continue to expand in terms of geographic and product coverage. The most common S&L programs include mandatory minimum energy performance standards (MEPS) that seek to push the market for efficient products, and energy information and endorsement labels that seek to pull the market. This study seeks to review and compare some of the earliest and most well-developed S&L programs in three countries and one region: the U.S. MEPS and ENERGY STAR, Australia MEPS and Energymore » Label, European Union MEPS and Ecodesign requirements and Energy Label and Japanese Top Runner programs. For each program, key elements of S&L programs are evaluated and comparative analyses across the programs undertaken to identify best practice examples of individual elements as well as cross-cutting factors for success and lessons learned in international S&L program development and implementation. The international review and comparative analysis identified several overarching themes and highlighted some common factors behind successful program elements. First, standard-setting and programmatic implementation can benefit significantly from a legal framework that stipulates a specific timeline or schedule for standard-setting and revision, product coverage and legal sanctions for non-compliance. Second, the different MEPS programs revealed similarities in targeting efficiency gains that are technically feasible and economically justified as the principle for choosing a standard level, in many cases at a level that no product on the current market could reach. Third, detailed survey data such as the U.S. Residential Energy Consumption Survey (RECS) and rigorous analyses provide a strong foundation for standard-setting while incorporating the participation of different groups of stakeholders further strengthen the process. Fourth, sufficient program resources for program implementation and evaluation are critical to the effectiveness of standards and labeling programs and cost-sharing between national and local governments can help ensure adequate resources and uniform implementation. Lastly, check-testing and punitive measures are important forms of enforcement while the cancellation of registration or product sales-based fines have also proven effective in reducing non-compliance. The international comparative analysis also revealed the differing degree to which the level of government decentralization has influenced S&L programs and while no single country has best practices in all elements of standards and labeling development and implementation, national examples of best practices for specific elements do exist. For example, the U.S. has exemplified the use of rigorous analyses for standard-setting and robust data source with the RECS database while Japan's Top Runner standard-setting principle has motivated manufacturers to exceed targets. In terms of standards implementation and enforcement, Australia has demonstrated success with enforcement given its long history of check-testing and enforcement initiatives while mandatory information-sharing between EU jurisdictions on compliance results is another important enforcement mechanism. These examples show that it is important to evaluate not only the drivers of different paths of standards and labeling development, but also the country-specific context for best practice examples in order to understand how and why certain elements of specific S&L programs have been effective.« less

RECOMMENDED FOUNDATION FILL MATERIALS CONSTRUCTION STANDARD OF THE FLORIDA RADON RESEARCH PROGRAM

EPA Science Inventory

The report summarizes the technical basis for a recommended foundation fill materials standard for new construction houses in Florida. he radon-control construction standard was developed by the Florida Radon Research Program (FRRP). ill material standards are formulated for: (1)...

45 CFR 302.39 - Standards for program operation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... (CHILD SUPPORT ENFORCEMENT PROGRAM), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND... provide that the IV-D agency will comply with the standards for program operation and the organizational...

Contextualized IT Education in Tanzania: Beyond Standard IT Curricula

ERIC Educational Resources Information Center

Tedre, Matti; Bangu, Nicholas; Nyagava, Seth I.

2009-01-01

Tumaini University at Iringa, Tanzania, started a new B.Sc. program in IT in 2007. In the course of planning and implementation of the program, we found out that standard ACM/IEEE IT curricula are not adequate for an IT program in a poor, developing country. The standard curricula describe, in detail, the competences that IT specialists in…

Preparing Teachers for Diversity: Examination of Teacher Certification and Program Accreditation Standards in the 50 States and Washington, DC

ERIC Educational Resources Information Center

Akiba, Motoko; Cockrell, Karen Sunday; Simmons, Juanita Cleaver; Han, Seunghee; Agarwal, Geetika

2010-01-01

State departments of education can play an important role in preparing teachers for effectively teaching diverse learners in our schools through state policies and standards on teacher certification and teacher education program accreditation. We conducted a content analysis of state standards on teacher certification and program accreditation in…

Digital Mapping, Charting and Geodesy Data Standardization

DTIC Science & Technology

1994-12-19

The primary objective of the audit was to evaluate DMA’s implementation of the Defense Standardization Program. Specifically, the audit determined...interoperability of digital MC&G data. The audit also evaluated DMA’s implementation of the DoD Internal Management Control Program as it pertains to DMA’S implementation of the Defense Standardization Program.

An Interpretative Phenomenological Analysis of the Common Core Standards Program in the State of South Dakota

ERIC Educational Resources Information Center

Alase, Abayomi

2017-01-01

This interpretative phenomenological analysis (IPA) study investigated and interpreted the Common Core State Standards program (the phenomenon) that has been the dominating topic of discussions amongst educators all across the country since the inauguration of the program in 2014/2015 school session. Common Core State Standards (CCSS) was a…

Identifying Strategies Programs Adopt to Meet Healthy Eating and Physical Activity Standards in Afterschool Programs

ERIC Educational Resources Information Center

Weaver, Robert G.; Moore, Justin B.; Turner-McGrievy, Brie; Saunders, Ruth; Beighle, Aaron; Khan, M. Mahmud; Chandler, Jessica; Brazendale, Keith; Randell, Allison; Webster, Collin; Beets, Michael W.

2017-01-01

Background: The YMCA of USA has adopted Healthy Eating and Physical Activity (HEPA) Standards for its afterschool programs (ASPs). Little is known about strategies YMCA ASPs are implementing to achieve Standards and these strategies' effectiveness. Aims: (1) Identify strategies implemented in YMCA ASPs and (2) evaluate the relationship between…

Validation of Subject Areas of CAS Professional Studies Standards for Master's Level Student Affairs Professional Preparation Programs

ERIC Educational Resources Information Center

Young, Dallin George; Dean, Laura A.

2015-01-01

The standards for Master's Level Student Affairs Professional Preparation Programs, first published in 1986, were among the first standards published by the Council for the Advancement of Standards in Higher Education (CAS; Ebbers & Kruempel, 1992). With the latest revision in 2012, the CAS standards for preparation of student affairs…

Illinois Occupational Skill Standards: Nursing Cluster.

ERIC Educational Resources Information Center

Illinois Occupational Skill Standards and Credentialing Council, Carbondale.

These skill standards, developed through a consortium of educational and industry partners in Illinois, serve as guides to workforce preparation program providers to define content for their programs and to employers to establish the skills and standards necessary for job acquisition and performance. The skill standards include the following…

77 FR 38743 - Energy Efficiency Program for Consumer Products: Energy Conservation Standards for Battery...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-29

... Efficiency Program for Consumer Products: Energy Conservation Standards for Battery Chargers and External... energy conservation standards for battery chargers and external power supplies. DATES: Comments must be... (``Notice of Proposed Rulemaking to Establish Energy Conservation Standards for Battery Chargers and...

20 CFR 632.89 - Performance standards.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false Performance standards. 632.89 Section 632.89... EMPLOYMENT AND TRAINING PROGRAMS Program Design and Management § 632.89 Performance standards. The Department of Labor shall establish performance standards for all Native American grantees (section 401(h)(1...

20 CFR 632.89 - Performance standards.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Performance standards. 632.89 Section 632.89... EMPLOYMENT AND TRAINING PROGRAMS Program Design and Management § 632.89 Performance standards. The Department of Labor shall establish performance standards for all Native American grantees (section 401(h)(1...

Employee Perceptions of Workplace Health Promotion Programs: Comparison of a Tailored, Semi-Tailored, and Standardized Approach.

PubMed

Street, Tamara D; Lacey, Sarah J

2018-04-28

In the design of workplace health promotion programs (WHPPs), employee perceptions represent an integral variable which is predicted to translate into rate of user engagement (i.e., participation) and program loyalty. This study evaluated employee perceptions of three workplace health programs promoting nutritional consumption and physical activity. Programs included: (1) an individually tailored consultation with an exercise physiologist and dietitian; (2) a semi-tailored 12-week SMS health message program; and (3) a standardized group workshop delivered by an expert. Participating employees from a transport company completed program evaluation surveys rating the overall program, affect, and utility of: consultations ( n = 19); SMS program ( n = 234); and workshops ( n = 86). Overall, participants’ affect and utility evaluations were positive for all programs, with the greatest satisfaction being reported in the tailored individual consultation and standardized group workshop conditions. Furthermore, mode of delivery and the physical presence of an expert health practitioner was more influential than the degree to which the information was tailored to the individual. Thus, the synergy in ratings between individually tailored consultations and standardized group workshops indicates that low-cost delivery health programs may be as appealing to employees as tailored, and comparatively high-cost, program options.

Industrial Education. Vocational Education Program Courses Standards.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee. Div. of Applied Tech., Adult, and Community Education.

This document contains vocational education program course standards for exploratory courses, practical arts courses, and job preparatory programs offered at the secondary and postsecondary level as part of the industrial education component in Florida. Curriculum frameworks are provided for 144 programs/clusters; representative topics are as…

POTENTIAL RADIOACTIVE POLLUTANTS RESULTING FROM EXPANDED ENERGY PROGRAMS

EPA Science Inventory

An effective environmental monitoring program must have a quality assurance component to assure the production of valid data. Quality assurance has many components: calibration standards, standard reference materials, standard reference methods, interlaboratory comparison studies...

75 FR 65517 - Canadian Standards Association; Expansion of Recognition

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-25

... Nationally Recognized Testing Laboratory (NRTL). CSA's expansion covers the use of additional test standards...) The type of products the NRTL may test, with each type specified by its applicable test standard; (2... activities for test standards within the NRTL's scope; and (3) the supplemental program(s) that the NRTL may...

Illinois Occupational Skill Standards: Physical Therapist Assistant Cluster.

ERIC Educational Resources Information Center

Illinois Occupational Skill Standards and Credentialing Council, Carbondale.

These skill standards, developed through a consortium of educational and industry partners in Illinois, serve as guides to workforce preparation program providers to define content for their programs and to employers to establish the skills and standards necessary for job acquisition and performance. The skill standards include the following…

7 CFR 220.8 - Nutrition standards and menu planning approaches for breakfasts.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 4 2011-01-01 2011-01-01 false Nutrition standards and menu planning approaches for... NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SCHOOL BREAKFAST PROGRAM § 220.8 Nutrition standards and menu planning approaches for breakfasts. (a) What are the nutrition standards for...

7 CFR 220.8 - Nutrition standards and menu planning approaches for breakfasts.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 4 2012-01-01 2012-01-01 false Nutrition standards and menu planning approaches for... NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SCHOOL BREAKFAST PROGRAM § 220.8 Nutrition standards and menu planning approaches for breakfasts. (a) What are the nutrition standards for...

7 CFR 220.8 - Nutrition standards and menu planning approaches for breakfasts.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 4 2010-01-01 2010-01-01 false Nutrition standards and menu planning approaches for... NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SCHOOL BREAKFAST PROGRAM § 220.8 Nutrition standards and menu planning approaches for breakfasts. (a) What are the nutrition standards for...

10 CFR 851.23 - Safety and health standards.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Safety and health standards. 851.23 Section 851.23 Energy DEPARTMENT OF ENERGY WORKER SAFETY AND HEALTH PROGRAM Specific Program Requirements § 851.23 Safety and health standards. (a) Contractors must comply with the following safety and health standards that are...

10 CFR 851.23 - Safety and health standards.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Safety and health standards. 851.23 Section 851.23 Energy DEPARTMENT OF ENERGY WORKER SAFETY AND HEALTH PROGRAM Specific Program Requirements § 851.23 Safety and health standards. (a) Contractors must comply with the following safety and health standards that are...

10 CFR 851.23 - Safety and health standards.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Safety and health standards. 851.23 Section 851.23 Energy DEPARTMENT OF ENERGY WORKER SAFETY AND HEALTH PROGRAM Specific Program Requirements § 851.23 Safety and health standards. (a) Contractors must comply with the following safety and health standards that are...

10 CFR 851.23 - Safety and health standards.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Safety and health standards. 851.23 Section 851.23 Energy DEPARTMENT OF ENERGY WORKER SAFETY AND HEALTH PROGRAM Specific Program Requirements § 851.23 Safety and health standards. (a) Contractors must comply with the following safety and health standards that are...

10 CFR 851.23 - Safety and health standards.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Safety and health standards. 851.23 Section 851.23 Energy DEPARTMENT OF ENERGY WORKER SAFETY AND HEALTH PROGRAM Specific Program Requirements § 851.23 Safety and health standards. (a) Contractors must comply with the following safety and health standards that are...

Illinois Occupational Skill Standards: Medical Office Cluster.

ERIC Educational Resources Information Center

Illinois Occupational Skill Standards and Credentialing Council, Carbondale.

These skill standards, developed through a consortium of educational and industry partners in Illinois, serve as guides to workforce preparation program providers to define content for their programs and to employers to establish the skills and standards necessary for job acquisition and performance. The skill standards include the following…

Illinois Occupational Skill Standards: Press Operations Cluster.

ERIC Educational Resources Information Center

Illinois Occupational Skill Standards and Credentialing Council, Carbondale.

These skill standards, developed through a consortium of educational and industry partners in Illinois, serve as guides to workforce preparation program providers to define content for their programs and to employers to establish the skills and standards necessary for job acquisition and performance. The skill standards include the following…

ISLLC/ELCC Standards Implementation: Do Educational Administration Faculty Practice What They Preach?

ERIC Educational Resources Information Center

Machado, Crystal

2012-01-01

Both the 1996 Interstate School Leadership Licensure Consortium (ISLLC) standards and the 2002 Educational Leadership Constituent Council (ELCC) standards, adopted by preparation programs nationwide have a strong emphasis on democratic ideals. By aligning their programs with these standards education administration faculty have taken a step in the…

40 CFR 80.1290 - How are standard benzene credits generated?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 17 2012-07-01 2012-07-01 false How are standard benzene credits... PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Benzene Averaging, Banking and Trading (abt) Program § 80.1290 How are standard benzene credits generated? (a) The standard credit averaging...

40 CFR 80.1290 - How are standard benzene credits generated?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 16 2011-07-01 2011-07-01 false How are standard benzene credits... PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Benzene Averaging, Banking and Trading (abt) Program § 80.1290 How are standard benzene credits generated? (a) The standard credit averaging...

40 CFR 80.1290 - How are standard benzene credits generated?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 17 2014-07-01 2014-07-01 false How are standard benzene credits... PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Benzene Averaging, Banking and Trading (abt) Program § 80.1290 How are standard benzene credits generated? (a) The standard credit averaging...

40 CFR 80.1290 - How are standard benzene credits generated?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 16 2010-07-01 2010-07-01 false How are standard benzene credits... PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Benzene Averaging, Banking and Trading (abt) Program § 80.1290 How are standard benzene credits generated? (a) The standard credit averaging...

40 CFR 80.1290 - How are standard benzene credits generated?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 17 2013-07-01 2013-07-01 false How are standard benzene credits... PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Benzene Averaging, Banking and Trading (abt) Program § 80.1290 How are standard benzene credits generated? (a) The standard credit averaging...

48 CFR 926.7004 - Size standard for Energy Policy Act procurements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Size standard for Energy... ENERGY SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Implementation of Section 3021 of the Energy Policy Act of 1992 926.7004 Size standard for Energy Policy Act procurements. The size standard for...

48 CFR 926.7004 - Size standard for Energy Policy Act procurements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Size standard for Energy... ENERGY SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Implementation of Section 3021 of the Energy Policy Act of 1992 926.7004 Size standard for Energy Policy Act procurements. The size standard for...

48 CFR 926.7004 - Size standard for Energy Policy Act procurements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Size standard for Energy... ENERGY SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Implementation of Section 3021 of the Energy Policy Act of 1992 926.7004 Size standard for Energy Policy Act procurements. The size standard for...

48 CFR 926.7004 - Size standard for Energy Policy Act procurements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Size standard for Energy... ENERGY SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Implementation of Section 3021 of the Energy Policy Act of 1992 926.7004 Size standard for Energy Policy Act procurements. The size standard for...

Illinois Occupational Skill Standards: Retail Garden Center Cluster.

ERIC Educational Resources Information Center

Illinois Occupational Skill Standards and Credentialing Council, Carbondale.

These skill standards, developed through a consortium of educational and industry partners in Illinois, serve as guides to workforce preparation program providers to define content for their programs and to employers to establish the skills and standards necessary for job acquisition and performance. The skill standards include the following…

20 CFR 633.321 - Performance standards for section 402 programs.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Performance standards for section 402 programs. 633.321 Section 633.321 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR MIGRANT AND SEASONAL FARMWORKER PROGRAMS Program Design and Administrative Procedures § 633.321...

Standard spacecraft economic analysis. Volume 2: Findings and conclusions

NASA Technical Reports Server (NTRS)

Harris, E. D.; Large, J. P.

1976-01-01

The comparative program costs associated with use of various standardized spacecraft for Air Force space test program missions to be flown on the space shuttle were studied in two phases. In the first phase, a variety of procurement mixes composed of existing or programmed NASA standard spacecraft designs and an Air Force standard spacecraft design were considered. The second phase dealt with additional procurement options using an upgraded version of an existing NASA design. The results of both phases are discussed.

Position of the American Dietetic Association: nutrition standards for child-care programs.

PubMed

1999-08-01

ADA supports achievement of comprehensive nutrition standards in child-care programs. The standards presented in this position paper focus on meeting the child's nutrition needs and providing a safe and pleasant environment that promotes acquisition of eating habits that prevent disease and enable healthy growth and development. Dietetics professionals can play a powerful role in advocating and assisting the acceptance of child-care nutrition standards by parents, caregivers, foodservice personnel, and directors and policy makers for child-care programs.

Evaluation of Arabic Language Learning Program for Non-Native Speakers in Saudi Electronic University According to Total Quality Standards

ERIC Educational Resources Information Center

Alowaydhi, Wafa Hafez

2016-01-01

The current study aimed at standardizing the program of learning Arabic for non-native speakers in Saudi Electronic University according to certain standards of total quality. To achieve its purpose, the study adopted the descriptive analytical method. The author prepared a measurement tool for evaluating the electronic learning programs in light…

Moving beyond Debate: Support for CACREP's Standard Requiring 60 Credit Hours for School Counseling Programs

ERIC Educational Resources Information Center

Merlin, Clare; Pagano, Timothy; George, Amanda; Zanone, Cassandra; Newman, Benjamin

2017-01-01

The Council for Accreditation of Counseling and Related Educational Programs (CACREP) recently released its 2016 standards. Included in these standards is a requirement for school counseling master's programs to have a minimum of 60 credit hours by the year 2020. This credit hour requirement is an increase from the previous 48-hour requirement and…

Recommended Standards for Teacher Education. The Accreditation of Basic and Advanced Preparation Programs for Professional School Personnel.

ERIC Educational Resources Information Center

American Association of Colleges for Teacher Education, Washington, DC.

The recommended standards for teacher education presented in this booklet are the result of a 3-year study conducted by the Evaluative Criteria Study Committee of AACTE. The recommendations are presented in two major sections, one concerned with standards for basic teacher education programs (programs for the initial preparation of teachers…

Vermont Core Standards and Self-Assessment Tool for Center-Based Early Childhood Programs.

ERIC Educational Resources Information Center

Vermont State Agency of Human Services, Waterbury.

In response to the desire to create for child development services a unified system which shares common standards for quality and respects the diversity and uniqueness of individuals and of programs, a committee of the Early Childhood Work Group collected and compared all the different standards now in force for the early childhood programs in the…

40 CFR 131.8 - Requirements for Indian Tribes to administer a water quality standards program.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 22 2011-07-01 2011-07-01 false Requirements for Indian Tribes to administer a water quality standards program. 131.8 Section 131.8 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS WATER QUALITY STANDARDS General Provisions § 131.8 Requirements for Indian Tribes to administer a wate...

40 CFR 131.8 - Requirements for Indian Tribes to administer a water quality standards program.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Requirements for Indian Tribes to administer a water quality standards program. 131.8 Section 131.8 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS WATER QUALITY STANDARDS General Provisions § 131.8 Requirements for Indian Tribes to administer a wate...

Specification for Teaching Machines and Programmes (Interchangeability of Programmes). Part 1, Linear Machines and Programmes.

ERIC Educational Resources Information Center

British Standards Institution, London (England).

To promote interchangeability of teaching machines and programs, so that the user is not so limited in his choice of programs, the British Standards Institute has offered a standard. Part I of the standard deals with linear teaching machines and programs that make use of the roll or sheet methods of presentation. Requirements cover: spools,…

The opportunities for and challenges of common integrated electronics

NASA Astrophysics Data System (ADS)

Nelson, J. R.; Retterer, Bernard L.; Cloud, Harley A.

1994-02-01

This document summarizes a portion of IDA's work concerning common integrated electronics and the potential cost savings of using common electronic hardware and software. It addresses trends in avionics costs and recent experiences in applying common electronic standards to weapon programs as a way to reduce costs. The following essential elements of a program to acquire common integrated electronics are explored: (1) integrated system architecture; (2) advanced technology programs; (3) open system standards; (4) standard common modules; and (5) associated management and policies. The principal recommendation is that OSD support and coordinate such a-program by taking a strong leadership role and setting standards policy.

A review of standardized patients in clinical education: Implications for speech-language pathology programs.

PubMed

Hill, Anne E; Davidson, Bronwyn J; Theodoros, Deborah G

2010-06-01

The use of standardized patients has been reported as a viable addition to traditional models of professional practice education in medicine, nursing and allied health programs. Educational programs rely on the inclusion of work-integrated learning components in order to graduate competent practitioners. Allied health programs world-wide have reported increasing difficulty in attaining sufficient traditional placements for students within the workplace. In response to this, allied health professionals are challenged to be innovative and problem-solving in the development and maintenance of clinical education placements and to consider potential alternative learning opportunities for students. Whilst there is a bank of literature describing the use of standardized patients in medicine and nursing, reports of its use in speech-language pathology clinical education are limited. Therefore, this paper aims to (1) provide a review of literature reporting on the use of standardized patients within medical and allied health professions with particular reference to use in speech-language pathology, (2) discuss methodological and practical issues involved in establishing and maintaining a standardized patient program and (3) identify future directions for research and clinical programs using standardized patients to build foundation clinical skills such as communication, interpersonal interaction and interviewing.

A Study of Minimum Competency Programs. Final Comprehensive Report. Vol. 1. Vol. 2.

ERIC Educational Resources Information Center

Gorth, William Phillip; Perkins, Marcy R.

The status of minimum competency testing programs, as of June 30, 1979, is given through descriptions of 31 state programs and 20 local district programs. For each program, the following information is provided: legislative and policy history; implementation phase; goals; competencies to be tested; standards and standard setting; target groups and…

OpenCL: A Parallel Programming Standard for Heterogeneous Computing Systems.

PubMed

Stone, John E; Gohara, David; Shi, Guochun

2010-05-01

We provide an overview of the key architectural features of recent microprocessor designs and describe the programming model and abstractions provided by OpenCL, a new parallel programming standard targeting these architectures.

National standards for the long-term care ombudsman program and a tool to assess compliance: the Huber Badrak Borders Scales.

PubMed

Huber, R; Borders, K W; Badrak, K; Netting, F E; Nelson, H W

2001-04-01

We propose national standards previously recommended for the Long-Term Care Ombudsman Program by an Institute of Medicine program evaluation committee, and introduce a tool to measure the compliance of local ombudsman programs to those standards: the Huber Badrak Borders Scales. The best practices for ombudsman programs detailed in the committee's report were adapted to 43 Likert-type scales that were then averaged into 10 infrastructure component scales: (a) program structure, (b) qualifications of local ombudsmen, (c) legal authority, (d) financial resources, (e) management information systems, (f) legal resources, (g) human resources, (h) resident advocacy services, (i) systemic advocacy, and (j) educational services. The scales were pilot-tested in 1996 and 1999 with Kentucky ombudsmen. The means of 9 of these 10 scales were higher in 1999 than in 1996, suggesting that local ombudsman programs were more in compliance with the proposed standards in 1999 than three years earlier. The development process consisted of 10 adopt-test-revise-retest steps that can be replicated by other types of programs to develop program compliance tools.

2012 Standards for the Renewable Fuel Standard Program: Final Rulemaking

EPA Pesticide Factsheets

EPA is establishing the volume requirements and associated percentage standards that will apply under the RFS2 program in calendar year 2012 for cellulosic biofuel, biomass-based diesel, advanced biofuel, and total renewable fuel.

2011 Standards for the Renewable Fuel Standard Program: Final Rulemaking

EPA Pesticide Factsheets

EPA is finalizing the volume requirements and associated percentage standards that will apply under the RFS2 program in calendar year 2011 for cellulosic biofuel, biomass-based diesel, advanced biofuel, and total renewable fuel.

TWO NEW GAS STANDARDS PROGRAMS AT THE NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY

EPA Science Inventory

The EPA/NIST certified reference materials (CRM) program is being terminated and replaced with two new ones: the NIST Traceable Reference Materials (NTRM) and the Research Gas Mixture (RGM) programs. hese new programs are being implemented to provide NIST traceability to a wider ...

25 CFR 547.13 - What are the minimum technical standards for program storage media?

Code of Federal Regulations, 2013 CFR

2013-04-01

... storage media? 547.13 Section 547.13 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR... the minimum technical standards for program storage media? (a) Removable program storage media. All removable program storage media must maintain an internal checksum or signature of its contents...

25 CFR 547.13 - What are the minimum technical standards for program storage media?

Code of Federal Regulations, 2014 CFR

2014-04-01

... storage media? 547.13 Section 547.13 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR... the minimum technical standards for program storage media? (a) Removable program storage media. All removable program storage media must maintain an internal checksum or signature of its contents...

42 CFR Appendix D to Part 75 - Standards for Accreditation of Educational Programs for Nuclear Medicine Technologists

Code of Federal Regulations, 2012 CFR

2012-10-01

... technologist credentialed in nuclear medicine technology. 2. Instructional Staff—(a) Responsibilities. The...—Standards for Accreditation of Educational Programs for Nuclear Medicine Technologists A. Sponsorship 1... certificate documenting completion of the program. 2. Educational programs may be established in: (a...

42 CFR Appendix D to Part 75 - Standards for Accreditation of Educational Programs for Nuclear Medicine Technologists

Code of Federal Regulations, 2011 CFR

2011-10-01

... technologist credentialed in nuclear medicine technology. 2. Instructional Staff—(a) Responsibilities. The...—Standards for Accreditation of Educational Programs for Nuclear Medicine Technologists A. Sponsorship 1... certificate documenting completion of the program. 2. Educational programs may be established in: (a...

42 CFR Appendix D to Part 75 - Standards for Accreditation of Educational Programs for Nuclear Medicine Technologists

Code of Federal Regulations, 2013 CFR

2013-10-01

... technologist credentialed in nuclear medicine technology. 2. Instructional Staff—(a) Responsibilities. The...—Standards for Accreditation of Educational Programs for Nuclear Medicine Technologists A. Sponsorship 1... certificate documenting completion of the program. 2. Educational programs may be established in: (a...

42 CFR Appendix D to Part 75 - Standards for Accreditation of Educational Programs for Nuclear Medicine Technologists

Code of Federal Regulations, 2014 CFR

2014-10-01

... technologist credentialed in nuclear medicine technology. 2. Instructional Staff—(a) Responsibilities. The...—Standards for Accreditation of Educational Programs for Nuclear Medicine Technologists A. Sponsorship 1... certificate documenting completion of the program. 2. Educational programs may be established in: (a...

Development and Operation of a Voluntary Audit Program.

ERIC Educational Resources Information Center

Murphy, Jerome R.

This report describes a voluntary audit program implemented by the Educational Testing Service (ETS). The comprehensive audit program was developed to assure that all corporate programs adhere to the ETS Standards for Quality and Fairness. The standards address issues which relate to all ETS activities such as accountability, confidentiality of…

Care management program evaluation: constituents, conflicts, and moves toward standardization.

PubMed

Long, D Adam; Perry, Theodore L; Pelletier, Kenneth R; Lehman, Gregg O

2006-06-01

Care management program evaluations bring together constituents from finance, medicine, and social sciences. The differing assumptions and scientific philosophies that these constituents bring to the task often lead to frustrations and even contentions. Given the forms and variations of care management programs, the difficulty associated with program outcomes measurement should not be surprising. It is no wonder then that methods for clinical and economic evaluations of program efficacy continue to be debated and have yet to be standardized. We describe these somewhat hidden processes, examine where the industry stands, and provide recommendations for steps to standardize evaluation methodology.

Impact of low cost refurbishable and standard spacecraft upon future NASA space programs. Payload effects follow-on study

NASA Technical Reports Server (NTRS)

1972-01-01

The study has concluded that there are very large space program cost savings to be obtained by use of low cost, refurbishable, and standard spacecraft in conjunction with the shuttle transportation system. The range of space program cost savings for three different groups of programs are shown in quantitative terms. The total savings for the 91 programs will range from $13.4 billion to $18.0 billion depending on the degree of hardware standardization. These savings, principally resulting from payload cost reductions, tangibly support the development costs of the shuttle system.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoogheem, T.J.; Woods, L.A.

The Monsanto Analytical Testing (MAT) program was devised and implemented in order to provide analytical standards to Monsanto manufacturing plants involved in the self-monitoring of plant discharges as required by National Pollutant Discharge Elimination System (NPDES) permit conditions. Standards are prepared and supplied at concentration levels normally observed at each individual plant. These levels were established by canvassing all Monsanto plants having NPDES permits and by determining which analyses and concentrations were most appropriate. Standards are prepared by Monsanto's analyses and concentrations were most appropriate. Standards are prepared by Monsanto's Environmental Sciences Center (ESC) using Environmental Protection Agency (EPA) methods.more » Eleven standards are currently available, each in three concentrations. Standards are issued quarterly in a company internal round-robin program or on a per request basis or both. Since initiation of the MAT program in 1981, the internal round-robin program has become an integral part of Monsanto's overall Good Laboratory Practices (GLP) program. Overall, results have shown that the company's plant analytical personnel can accurately analyze and report standard test samples. More importantly, such personnel have gained increased confidence in their ability to report accurate values for compounds regulated in their respective plant NPDES permits. 3 references, 3 tables.« less

13 CFR 121.702 - What size standards are applicable to the SBIR program?

Code of Federal Regulations, 2010 CFR

2010-01-01

... Requirements for the Small Business Innovation Research (sbir) Program § 121.702 What size standards are... Innovation Research (SBIR) program, a business concern must meet the requirements of paragraphs (a) and (b...

OpenCL: A Parallel Programming Standard for Heterogeneous Computing Systems

PubMed Central

Stone, John E.; Gohara, David; Shi, Guochun

2010-01-01

We provide an overview of the key architectural features of recent microprocessor designs and describe the programming model and abstractions provided by OpenCL, a new parallel programming standard targeting these architectures. PMID:21037981

76 FR 18166 - Technology Innovation Program Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-01

... DEPARTMENT OF COMMERCE National Institute of Standards and Technology Technology Innovation Program Advisory Board AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of public meeting. SUMMARY: The Technology Innovation Program Advisory Board, National...

75 FR 62369 - Technology Innovation Program Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-08

... DEPARTMENT OF COMMERCE National Institute of Standards and Technology Technology Innovation Program Advisory Board AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of public meeting. SUMMARY: The Technology Innovation Program Advisory Board, National...

75 FR 22553 - Technology Innovation Program Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-29

... DEPARTMENT OF COMMERCE National Institute of Standards and Technology Technology Innovation Program Advisory Board AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of public meeting. SUMMARY: The Technology Innovation Program Advisory Board, National...

Illinois Occupational Skill Standards: Lodging Cluster.

ERIC Educational Resources Information Center

Illinois Occupational Skill Standards and Credentialing Council, Carbondale.

This document of skill standards for the lodging cluster serves as a guide to workforce preparation program providers in defining content for their programs and to employers to establish the skills and standards necessary for job acquisition. These 28 occupational skill standards describe what people should know and be able to do in an…

Illinois Occupational Skill Standards: Greenhouse/Nursery Cluster.

ERIC Educational Resources Information Center

Illinois Occupational Skill Standards and Credentialing Council, Carbondale.

This document of skill standards for the greenhouse/nursery cluster serves as a guide to workforce preparation program providers in defining content for their programs and to employers to establish the skills and standards necessary for job acquisition. These 23 occupational skill standards describe what people should know and be able to do in an…

Illinois Occupational Skill Standards: Machining Skills Cluster.

ERIC Educational Resources Information Center

Illinois Occupational Skill Standards and Credentialing Council, Carbondale.

This document of skill standards for the machining skills cluster serves as a guide to workforce preparation program providers in defining content for their programs and to employers to establish the skills and standards necessary for job acquisition. These 67 occupational skill standards describe what people should know and be able to do in an…

Illinois Occupational Skill Standards: Landscape Technician Cluster.

ERIC Educational Resources Information Center

Illinois Occupational Skill Standards and Credentialing Council, Carbondale.

This document of skill standards for the landscape technician cluster serves as a guide to workforce preparation program providers in defining content for their programs and to employers to establish the skills and standards necessary for job acquisition. These 19 occupational skill standards describe what people should know and be able to do in…

Virginia Standards Predated the Common Core Initiative

ERIC Educational Resources Information Center

Knowledge Quest, 2014

2014-01-01

The Virginia Board of Education is committed to the Virginia Standards of Learning (SOL) program and opposed to adoption of the newly developed Common Core State Standards as a prerequisite for participation in federal competitive grant and entitlement programs. The Standards of Learning are clear and rigorous and have won the acceptance and trust…

75 FR 17036 - Energy Conservation Program: Energy Conservation Standards for Small Electric Motors; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-05

... Conservation Program: Energy Conservation Standards for Small Electric Motors; Correction AGENCY: Office of... standards for small electric motors, which was published on March 9, 2010. In that final rule, the U.S... titled ``Energy Conservation Standards for Small Electric Motors.'' 75 FR 10874. Since the publication of...

An Application of Indian Health Service Standards for Alcoholism Programs.

ERIC Educational Resources Information Center

Burns, Thomas R.

1984-01-01

Discusses Phoenix-area applications of 1981 Indian Health Service standards for alcoholism programs. Results of standard statistical techniques note areas of deficiency through application of a one-tailed z test at .05 level of significance. Factor analysis sheds further light on design of standards. Implications for revisions are suggested.…

A Descriptive Analysis of the Application of PETE Standards

ERIC Educational Resources Information Center

Taliaferro, Andrea R.; Ayers, Suzan F.; Housner, Lynn

2017-01-01

Background: In 2008, Ayers and Housner published a descriptive analysis of undergraduate PETE programs' application of the 2003 NASPE standards. The shift in emphases from the 2003 to 2008 standards motivated the examination of how U.S. PETE programs address current standards. Purpose: Based upon recommendations for future research, this study…

76 FR 56126 - Energy Conservation Program: Treatment of “Smart” Appliances in Energy Conservation Standards and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-12

...'s energy conservation standards, as well as in test procedures used to demonstrate compliance with...'' appliances in the development of DOE's energy conservation standards, as well as in test procedures used to... Conservation Program: Treatment of ``Smart'' Appliances in Energy Conservation Standards and Test Procedures...

Effect of an Internet-Based Program on Weight Loss for Low-Income Postpartum Women: A Randomized Clinical Trial.

PubMed

Phelan, Suzanne; Hagobian, Todd; Brannen, Anna; Hatley, Karen E; Schaffner, Andrew; Muñoz-Christian, Karen; Tate, Deborah F

2017-06-20

Postpartum weight retention increases lifetime risk of obesity and related morbidity. Few effective interventions exist for multicultural, low-income women. To test whether an internet-based weight loss program in addition to the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC program) for low-income postpartum women could produce greater weight loss than the WIC program alone over 12 months. A 12-month, cluster randomized, assessor-blind, clinical trial enrolling 371 adult postpartum women at 12 clinics in WIC programs from the California central coast between July 2011 and May 2015 with data collection completed in May 2016. Clinics were randomized to the WIC program (standard care group) or the WIC program plus a 12-month primarily internet-based weight loss program (intervention group), including a website with weekly lessons, web diary, instructional videos, computerized feedback, text messages, and monthly face-to-face groups at the WIC clinics. The primary outcome was weight change over 12 months, based on measurements at baseline, 6 months, and 12 months. Secondary outcomes included proportion returning to preconception weight and changes in physical activity and diet. Participants included 371 women (mean age, 28.1 years; Hispanic, 81.6%; mean weight above prepregnancy weight, 7.8 kg; mean months post partum, 5.2 months) randomized to the intervention group (n = 174) or standard care group (n = 197); 89.2% of participants completed the study. The intervention group produced greater mean 12-month weight loss compared with the standard care group (3.2 kg in the intervention group vs 0.9 kg in standard care group, P < .001; difference, 2.3 kg (95% CI, 1.1 to 3.5). More participants in the intervention group than the standard care group returned to preconception weight by 12 months (32.8% in the intervention group vs 18.6% in the standard care group, P < .001; difference, 14.2 percentage points [95% CI, 4.7 to 23.5]). The intervention group and standard care group did not significantly differ in 12-month changes in physical activity (mean [95% CI]: -7.8 min/d [-16.1 to 0.4] in the intervention group vs -7.2 min/d [-14.6 to 0.3] in the standard care group; difference, -0.7 min/d [95% CI, -42.0 to 10.6], P = .76), calorie intake (mean [95% CI]: -298 kcal/d [-423 to -174] in the intervention group vs -144 kcal/d [-257 to -32] in the standard care group; difference, -154 kcal/d [-325 to 17], P = .06), or incidences of injury (16 in the intervention group vs 16 in the standard care group) or low breastmilk supply from baseline to month 6 (21 of 61 participants in the intervention group vs 23 of 72 participants in the standard care group) and from month 6 to 12 (13 of 32 participants in the intervention group vs 14 of 37 participants in the standard care group). Among low-income postpartum women, an internet-based weight loss program in addition to the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC program) compared with the WIC program alone resulted in a statistically significant greater weight loss over 12 months. Further research is needed to determine program and cost-effectiveness as part of the WIC program. clinicaltrials.gov Identifier: NCT01408147.

2013 Renewable Fuel Standards for Renewable Fuel Standard Program (RFS2) Final Rulemaking

EPA Pesticide Factsheets

EPA is establishing the volume requirements and associated percentage standards that apply under the RFS2 program in calendar year 2013 for cellulosic biofuel, biomass-based diesel, advanced biofuel, and total renewable fuel.

Information Literacy--Where Do We Go from Here?

ERIC Educational Resources Information Center

Koch, Melissa

2001-01-01

Defines information literacy and discusses ways that teachers can integrate it into the curriculum. Topics include education policy; funding for technology; standards, particularly state standards; separate standards for library media programs; assessment; and using the Big6 program. (LRW)

2014 Renewable Fuel Standards under Renewable Fuel Standard Program: Notice of Proposed Rulemaking

EPA Pesticide Factsheets

EPA is proposing the volume requirements and associated percentage standards that would apply under the RFS2 program in calendar year 2014 for cellulosic biofuel, biomass-based diesel, advanced biofuel, and total renewable fuel.

Users guide for ENVSTD program Version 2. 0 and LTGSTD program Version 2. 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crawley, D.B.; Riesen, P.K.; Briggs, R.S.

1989-02-01

On January 30, 1989, the US Department of Energy (DOE) promulgated 10 CFR Part 435, Subpart A, an Interim Rule entitled ''Energy Conservation Voluntary Performance Standards for New Commercial and Multi-Family High Rise Residential Buildings; Mandatory for New Federal Buildings.'' As a consequence, federal agencies must design all future federal commercial and multifamily high rise residential buildings in accordance with the Standards, or show that their current standards already meet or exceed the energy-efficiency requirements of the Standards. Although these newly enacted Standards do not regulate the design of nonfederal buildings, DOE recommends that all design professionals use the Standardsmore » as guidelines for designing energy-conserving buildings. To encourage private sector use, the Standards were presented in the January 30, 1989, Federal Register in the format typical of commercial standards rather than a federal regulation. As a further help, DOE supported the development of various microcomputer programs to ease the use of the Standards. Two of these programs/emdash/ENVSTD (Version 2.0) and LTGSTD (Version 2.0)/emdash/are detailed in this users guide and provided on the accompanying diskette. This package, developed by Pacific Northwest Laboratory (PNL), is intended to facilitate the designer's use of the Standards dealing specifically with a building's envelope and lighting system designs. Using these programs will greatly simplify the designer's task of performing the sometimes complex calculations needed to determine a design's compliance with the Standards. 3 refs., 6 figs.« less

Employee Perceptions of Workplace Health Promotion Programs: Comparison of a Tailored, Semi-Tailored, and Standardized Approach

PubMed Central

Street, Tamara D.; Lacey, Sarah J.

2018-01-01

In the design of workplace health promotion programs (WHPPs), employee perceptions represent an integral variable which is predicted to translate into rate of user engagement (i.e., participation) and program loyalty. This study evaluated employee perceptions of three workplace health programs promoting nutritional consumption and physical activity. Programs included: (1) an individually tailored consultation with an exercise physiologist and dietitian; (2) a semi-tailored 12-week SMS health message program; and (3) a standardized group workshop delivered by an expert. Participating employees from a transport company completed program evaluation surveys rating the overall program, affect, and utility of: consultations (n = 19); SMS program (n = 234); and workshops (n = 86). Overall, participants’ affect and utility evaluations were positive for all programs, with the greatest satisfaction being reported in the tailored individual consultation and standardized group workshop conditions. Furthermore, mode of delivery and the physical presence of an expert health practitioner was more influential than the degree to which the information was tailored to the individual. Thus, the synergy in ratings between individually tailored consultations and standardized group workshops indicates that low-cost delivery health programs may be as appealing to employees as tailored, and comparatively high-cost, program options. PMID:29710785

Drug-food interaction counseling programs in teaching hospitals.

PubMed

Wix, A R; Doering, P L; Hatton, R C

1992-04-01

The results of a survey to characterize drug-food interaction counseling programs in teaching hospitals and solicit opinions on these programs from pharmacists and dietitians are reported. A questionnaire was mailed to the pharmacy director and the director of dietary services at teaching hospitals nationwide. The questionnaire contained 33 questions relating to hospital characteristics, drug-food interaction counseling programs, and the standard calling for such programs issued by the Joint Commission on Accreditation of Healthcare Organizations. Of 792 questionnaires mailed, 425 were returned (response rate, 53.7). A majority of the pharmacists and dietitians (51.2%) did not consider their drug-food interaction counseling program to be formal; some had no program. The pharmacy department was involved more in program development than in the daily operation of such programs. The most frequent methods of identifying patients for counseling were using lists of patients' drugs and using physicians' orders. A mean of only five drugs were targeted per program. Slightly over half the respondents rated the Joint Commission standard less effective than other standards in its ability to improve patient care. A majority of teaching hospitals did not have formal drug-food interaction counseling programs. Pharmacists and dietitians did not view these programs as greatly beneficial and did not believe that the Joint Commission has clearly delineated the requirements for meeting its standard.

Neutron cross section standards and instrumentation. Annual report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wasson, O.A.

The objective of this interagency program is to provide accurate neutron interaction measurements for the US Department of Energy nuclear programs which include waste disposal, fusion, safeguards, defense, fission, and personnel protection. These measurements are also useful to other energy programs which indirectly use the unique properties of the neutron for diagnostic and analytical purposes. The work includes the measurement of reference cross sections and related neutron data employing unique facilities and capabilities at NIST and other laboratories as required; leadership and participation in international intercomparisons and collaborations; the preservation of standard reference deposits and the development of improved neutronmore » detectors and measurement methods. A related and essential element of the program is critical evaluation of neutron interaction data including international coordinations. Data testing of critical data for important applications is included. The program is jointly supported by the Department of Energy and the National Institute of Standards and Technology. This report from the National Institute of Standards and Technology contains a summary of the accomplishments of the Neutron Cross Section Standards and Instrumentation Project during the third year of this three-year interagency agreement. The proposed program and required budget for the following three years are also presented. The program continues the shifts in priority instituted in order to broaden the program base.« less

E-Standards For Mass Properties Engineering

NASA Technical Reports Server (NTRS)

Cerro, Jeffrey A.

2008-01-01

A proposal is put forth to promote the concept of a Society of Allied Weight Engineers developed voluntary consensus standard for mass properties engineering. This standard would be an e-standard, and would encompass data, data manipulation, and reporting functionality. The standard would be implemented via an open-source SAWE distribution site with full SAWE member body access. Engineering societies and global standards initiatives are progressing toward modern engineering standards, which become functioning deliverable data sets. These data sets, if properly standardized, will integrate easily between supplier and customer enabling technically precise mass properties data exchange. The concepts of object-oriented programming support all of these requirements, and the use of a JavaTx based open-source development initiative is proposed. Results are reported for activity sponsored by the NASA Langley Research Center Innovation Institute to scope out requirements for developing a mass properties engineering e-standard. An initial software distribution is proposed. Upon completion, an open-source application programming interface will be available to SAWE members for the development of more specific programming requirements that are tailored to company and project requirements. A fully functioning application programming interface will permit code extension via company proprietary techniques, as well as through continued open-source initiatives.

1996 DOE technical standards program workshop: Proceedings

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-07-01

The workshop theme is `The Strategic Standardization Initiative - A Technology Exchange and Global Competitiveness Challenge for DOE.` The workshop goal is to inform the DOE technical standards community of strategic standardization activities taking place in the Department, other Government agencies, standards developing organizations, and industry. Individuals working on technical standards will be challenged to improve cooperation and communications with the involved organizations in response to the initiative. Workshop sessions include presentations by representatives from various Government agencies that focus on coordination among and participation of Government personnel in the voluntary standards process; reports by standards organizations, industry, and DOEmore » representatives on current technology exchange programs; and how the road ahead appears for `information superhighway` standardization. Another session highlights successful standardization case studies selected from several sites across the DOE complex. The workshop concludes with a panel discussion on the goals and objectives of the DOE Technical Standards Program as envisioned by senior DOE management. The annual workshop on technical standards has proven to be an effective medium for communicating information related to standards throughout the DOE community. Technical standards are used to transfer technology and standardize work processes to produce consistent, acceptable results. They provide a practical solution to the Department`s challenge to protect the environment and the health and safety of the public and workers during all facility operations. Through standards, the technologies of industries and governments worldwide are available to DOE. The DOE Technical Standards Program, a Department-wide effort that crosscuts all organizations and disciplines, links the Department to those technologies.« less

76 FR 70970 - Technology Innovation Program Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-16

... DEPARTMENT OF COMMERCE National Institute of Standards and Technology Technology Innovation Program Advisory Board AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of public meeting. SUMMARY: The Technology Innovation Program (TIP) Advisory Board will...

45 CFR 170.555 - Certification to newer versions of certain standards.

Code of Federal Regulations, 2011 CFR

2011-10-01

... standards. 170.555 Section 170.555 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY Permanent Certification Program for HIT...

45 CFR 170.555 - Certification to newer versions of certain standards.

Code of Federal Regulations, 2012 CFR

2012-10-01

... standards. 170.555 Section 170.555 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY Permanent Certification Program for HIT...

40 CFR 146.61 - Applicability

Code of Federal Regulations, 2010 CFR

2010-07-01

... INJECTION CONTROL PROGRAM: CRITERIA AND STANDARDS Criteria and Standards Applicable to Class I Hazardous Waste Injection Wells § 146.61 Applicability (a) This subpart establishes criteria and standards for underground injection control programs to regulate Class I hazardous waste injection wells. Unless otherwise...

76 FR 22673 - Technology Innovation Program Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-22

... DEPARTMENT OF COMMERCE National Institute of Standards and Technology Technology Innovation Program Advisory Board AGENCY: National Institute of Standards and Technology, Department of Commerce... Standards and Technology (NIST) published a notice in the Federal Register announcing an open meeting for...

13 CFR 121.702 - What size standards are applicable to the SBIR program?

Code of Federal Regulations, 2012 CFR

2012-01-01

... to the SBIR program? 121.702 Section 121.702 Business Credit and Assistance SMALL BUSINESS... Requirements for the Small Business Innovation Research (sbir) Program § 121.702 What size standards are applicable to the SBIR program? To be eligible for award of funding agreements in the SBA's Small Business...

13 CFR 121.702 - What size standards are applicable to the SBIR program?

Code of Federal Regulations, 2011 CFR

2011-01-01

... to the SBIR program? 121.702 Section 121.702 Business Credit and Assistance SMALL BUSINESS... Requirements for the Small Business Innovation Research (sbir) Program § 121.702 What size standards are applicable to the SBIR program? To be eligible for award of funding agreements in the SBA's Small Business...

25 CFR 170.454 - What design standards are used in the IRR Program?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false What design standards are used in the IRR Program? 170.454 Section 170.454 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM Planning, Design, and Construction of Indian Reservation Roads Program Facilities...

Proposed Accreditation Standards for Degree-Granting Correspondence Programs Offered by Accredited Institutions.

ERIC Educational Resources Information Center

McGraw-Hill Continuing Education Center, Washington, DC.

A study on proposed accreditation standards grew out of a need to (1) stimulate the growth of quality correspondence degree programs; and (2) provide a policy for accreditation of correspondence degree programs so that graduates would be encouraged to pursue advanced degree programs offered elsewhere by educational institutions. The study focused…

An Evaluation of Perceptions of Form, Fit, Function (F3) Standardization on the Standard Inertial Navigation Unit (STD INU) Program.

DTIC Science & Technology

1987-12-01

support durring the first few years of operations, which provides an incentive for such innovations and defers the acquisition of AGE until the equipment...along with number of standard avionics programs worked and the ranks of each individual. Table 5. Expierence With Avionics Standardization Years

Automated Hypothesis Tests and Standard Errors for Nonstandard Problems with Description of Computer Package: A Draft.

ERIC Educational Resources Information Center

Lord, Frederic M.; Stocking, Martha

A general Computer program is described that will compute asymptotic standard errors and carry out significance tests for an endless variety of (standard and) nonstandard large-sample statistical problems, without requiring the statistician to derive asymptotic standard error formulas. The program assumes that the observations have a multinormal…

New Nutrition Standards for Idaho School Meals. Nourishing News. Volume 4, Issue 1

ERIC Educational Resources Information Center

Idaho State Department of Education, 2009

2009-01-01

Idaho Child Nutrition Programs (CNP) released the New Nutrition Standards for Idaho School Meals in January 2009 with the recommendation that all School Food Authorities fully implement the New Nutrition Standards for Idaho School Meals into their programs starting August 2009. Along with the release of the New Nutrition Standards for Idaho School…

STANDARD MEASUREMENT PROTOCOLS - FLORIDA RADON RESEARCH PROGRAM

EPA Science Inventory

The manual, in support of the Florida Radon Research Program, contains standard protocols for key measurements where data quality is vital to the program. t contains two sections. he first section, soil measurements, contains field sampling protocols for soil gas permeability and...

Nutriendo la Promesa: Materiales Para la Aplicacion de las Normas de Ejecucion del Programa Head Start. Guia Para la Utilizacion de los Materiales [y] Transparencias (Nurturing the Promise: Set of Training Materials on the Head Start Program Performance Standards. User's Guide [and] Set of Transparencies).

ERIC Educational Resources Information Center

Educational Services, Inc., Washington, DC.

Since 1975, the Head Start Program Performance Standards have defined the services that local programs are required to provide to enrolled children and families. With revisions effective in 1998, the Program Performance Standards translate the Head Start vision into quality practices implemented at the local level. This document is comprised of a…

12 CFR Appendix B to Part 30 - Interagency Guidelines Establishing Information Security Standards

Code of Federal Regulations, 2011 CFR

2011-01-01

... Establishing Information Security Standards Table of Contents I. Introduction A. Scope B. Preservation of... Security Program B. Objectives III. Development and Implementation of Customer Information Security Program.... Introduction The Interagency Guidelines Establishing Information Security Standards (Guidelines) set forth...

45 CFR 170.555 - Certification to newer versions of certain standards.

Code of Federal Regulations, 2014 CFR

2014-10-01

... standards. 170.555 Section 170.555 Public Welfare Department of Health and Human Services HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY ONC HIT Certification Program § 170.555...

45 CFR 170.555 - Certification to newer versions of certain standards.

Code of Federal Regulations, 2013 CFR

2013-10-01

... standards. 170.555 Section 170.555 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY ONC HIT Certification Program § 170.555...

32 CFR 147.19 - The three standards.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) The investigation standard for“Q” access authorizations and for access to top secret (including top secret Special Access Programs) and Sensitive Compartmented Information; (c) The reinvestigation standard... authorizations and for access to confidential and secret (including all secret-level Special Access Programs not...

Forming Facial Expressions Influences Assessment of Others' Dominance but Not Trustworthiness.

PubMed

Ueda, Yoshiyuki; Nagoya, Kie; Yoshikawa, Sakiko; Nomura, Michio

2017-01-01

Forming specific facial expressions influences emotions and perception. Bearing this in mind, studies should be reconsidered in which observers expressing neutral emotions inferred personal traits from the facial expressions of others. In the present study, participants were asked to make happy, neutral, and disgusted facial expressions: for "happy," they held a wooden chopstick in their molars to form a smile; for "neutral," they clasped the chopstick between their lips, making no expression; for "disgusted," they put the chopstick between their upper lip and nose and knit their brows in a scowl. However, they were not asked to intentionally change their emotional state. Observers judged happy expression images as more trustworthy, competent, warm, friendly, and distinctive than disgusted expression images, regardless of the observers' own facial expression. Observers judged disgusted expression images as more dominant than happy expression images. However, observers expressing disgust overestimated dominance in observed disgusted expression images and underestimated dominance in happy expression images. In contrast, observers with happy facial forms attenuated dominance for disgusted expression images. These results suggest that dominance inferred from facial expressions is unstable and influenced by not only the observed facial expression, but also the observers' own physiological states.

Correction of a Severely Rotated Maxillary Incisor by Elastics in Mixed Dentition Complicated by a Mesiodens.

PubMed

Sidiq, Mohsin; Yousuf, Asif; Bhat, Manohar; Sharma, Rajesh; Bhargava, Neha; Ganta, Shravani

2015-01-01

The aim of this case study was to report a potentially convenient approach instead of a conventional orthodontic procedure for correcting severe rotation of anterior tooth of an 11-year-old Indian boy, with a mixed dentition class I malocclusion. The child reported seeking treatment for severely rotated upper right central incisor with mesiodens and a single tooth crossbite. The supernumerary tooth was first extracted and bondable buttons were placed on the rotated tooth, an appliance composed of a removable plate with Adam's clasp with distal extension and a loop for engagement of elastics was delivered. Circumferential supracrestal fibrotomy was performed on the corrected derotated tooth. Then, Hawley's appliance with a z-spring and posterior bite plane was fabricated and placed for correction of crossbite. Thus, this removable appliance can be a simplified and a cost-effective treatment alternative for derotation of anterior tooth, especially during the mixed dentition period. How to cite this article: Sidiq M, Yousuf A, Bhat M, Sharma R, Bhargava N, Ganta S. Correction of a Severely Rotated Maxillary Incisor by Elastics in Mixed Dentition Complicated by a Mesiodens. Int J Clin Pediatr Dent 2015;8(3):234-238.

Structures of Staphylococcus aureus D-tagatose-6-phosphate kinase implicate domain motions in specificity and mechanism.

PubMed

Miallau, Linda; Hunter, William N; McSweeney, Sean M; Leonard, Gordon A

2007-07-06

High resolution structures of Staphylococcus aureus d-tagatose-6-phosphate kinase (LacC) in two crystal forms are herein reported. The structures define LacC in apoform, in binary complexes with ADP or the co-factor analogue AMP-PNP, and in a ternary complex with AMP-PNP and D-tagatose-6-phosphate. The tertiary structure of the LacC monomer, which is closely related to other members of the pfkB subfamily of carbohydrate kinases, is composed of a large alpha/beta core domain and a smaller, largely beta "lid." Four extended polypeptide segments connect these two domains. Dimerization of LacC occurs via interactions between lid domains, which come together to form a beta-clasp structure. Residues from both subunits contribute to substrate binding. LacC adopts a closed structure required for phosphoryl transfer only when both substrate and co-factor are bound. A reaction mechanism similar to that used by other phosphoryl transferases is proposed, although unusually, when both substrate and co-factor are bound to the enzyme two Mg(2+) ions are observed in the active site. A new motif of amino acid sequence conservation common to the pfkB subfamily of carbohydrate kinases is identified.

Correction of a Severely Rotated Maxillary Incisor by Elastics in Mixed Dentition Complicated by a Mesiodens

PubMed Central

Sidiq, Mohsin; Bhat, Manohar; Sharma, Rajesh; Bhargava, Neha; Ganta, Shravani

2015-01-01

ABSTRACT The aim of this case study was to report a potentially convenient approach instead of a conventional orthodontic procedure for correcting severe rotation of anterior tooth of an 11-year-old Indian boy, with a mixed dentition class I malocclusion. The child reported seeking treatment for severely rotated upper right central incisor with mesiodens and a single tooth crossbite. The supernumerary tooth was first extracted and bondable buttons were placed on the rotated tooth, an appliance composed of a removable plate with Adam’s clasp with distal extension and a loop for engagement of elastics was delivered. Circumferential supracrestal fibrotomy was performed on the corrected derotated tooth. Then, Hawley’s appliance with a z-spring and posterior bite plane was fabricated and placed for correction of crossbite. Thus, this removable appliance can be a simplified and a cost-effective treatment alternative for derotation of anterior tooth, especially during the mixed dentition period. How to cite this article: Sidiq M, Yousuf A, Bhat M, Sharma R, Bhargava N, Ganta S. Correction of a Severely Rotated Maxillary Incisor by Elastics in Mixed Dentition Complicated by a Mesiodens. Int J Clin Pediatr Dent 2015;8(3):234-238. PMID:26604544

Computing tools for implementing standards for single-case designs.

PubMed

Chen, Li-Ting; Peng, Chao-Ying Joanne; Chen, Ming-E

2015-11-01

In the single-case design (SCD) literature, five sets of standards have been formulated and distinguished: design standards, assessment standards, analysis standards, reporting standards, and research synthesis standards. This article reviews computing tools that can assist researchers and practitioners in meeting the analysis standards recommended by the What Works Clearinghouse: Procedures and Standards Handbook-the WWC standards. These tools consist of specialized web-based calculators or downloadable software for SCD data, and algorithms or programs written in Excel, SAS procedures, SPSS commands/Macros, or the R programming language. We aligned these tools with the WWC standards and evaluated them for accuracy and treatment of missing data, using two published data sets. All tools were tested to be accurate. When missing data were present, most tools either gave an error message or conducted analysis based on the available data. Only one program used a single imputation method. This article concludes with suggestions for an inclusive computing tool or environment, additional research on the treatment of missing data, and reasonable and flexible interpretations of the WWC standards. © The Author(s) 2015.

Guide for Operational Configuration Management Program including the adjunct programs of design reconstitution and material condition and aging management. Part 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This standard presents program criteria and implementation guidance for an operational configuration management program for DOE nuclear and non-nuclear facilities in the operational phase. Portions of this standard are also useful for other DOE processes, activities, and programs. This Part 1 contains foreword, glossary, acronyms, bibliography, and Chapter 1 on operational configuration management program principles. Appendices are included on configuration management program interfaces, and background material and concepts for operational configuration management.

78 FR 9529 - National School Lunch Program and School Breakfast Program: Nutrition Standards for All Foods...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-08

...This rule proposes to amend the National School Lunch Program and School Breakfast Program regulations consistent with amendments made in the Healthy, Hunger-Free Kids Act of 2010 (HHFKA). The HHFKA requires that the Secretary promulgate proposed regulations to establish nutrition standards for foods sold in schools other than those foods provided under the Child Nutrition Act of 1966 (CNA) and the Richard B. Russell National School Lunch Act (NSLA). The HHFKA amends the CNA, requiring that such standards shall be consistent with the most recent Dietary Guidelines for Americans and that the Secretary shall consider authoritative scientific recommendations for nutrition standards; existing school nutrition standards, including voluntary standards for beverages and snack foods; current State and local standards; the practical application of the nutrition standards; and special exemptions for infrequent school-sponsored fundraisers (other than fundraising through vending machines, school stores, snack bars, a la carte sales and any other exclusions determined by the Secretary). The HHFKA also amended the NSLA to require that schools participating in the National School Lunch Program make potable water available to children at no charge in the place where lunches are served during the meal service. These proposed changes are intended to improve the health and well-being of the Nation's children, increase consumption of healthful foods during the school day and create an environment that reinforces the development of healthy eating habits.

User Guide to RockJock - A Program for Determining Quantitative Mineralogy from X-Ray Diffraction Data

USGS Publications Warehouse

Eberl, D.D.

2003-01-01

RockJock is a computer program that determines quantitative mineralogy in powdered samples by comparing the integrated X-ray diffraction (XRD) intensities of individual minerals in complex mixtures to the intensities of an internal standard. Analysis without an internal standard (standardless analysis) also is an option. This manual discusses how to prepare and X-ray samples and mineral standards for these types of analyses and describes the operation of the program. Carefully weighed samples containing an internal standard (zincite) are ground in a McCrone mill. Randomly oriented preparations then are X-rayed, and the X-ray data are entered into the RockJock program. Minerals likely to be present in the sample are chosen from a list of standards, and the calculation is begun. The program then automatically fits the sum of stored XRD patterns of pure standard minerals (the calculated pattern) to the measured pattern by varying the fraction of each mineral standard pattern, using the Solver function in Microsoft Excel to minimize a degree of fit parameter between the calculated and measured pattern. The calculation analyzes the pattern (usually 20 to 65 degrees two-theta) to find integrated intensities for the minerals. Integrated intensities for each mineral then are determined from the proportion of each mineral standard pattern required to give the best fit. These integrated intensities then are compared to the integrated intensity of the internal standard, and the weight percentages of the minerals are calculated. The results are presented as a list of minerals with their corresponding weight percent. To some extent, the quality of the analysis can be checked because each mineral is analyzed independently, and, therefore, the sum of the analysis should approach 100 percent. Also, the method has been shown to give good results with artificial mixtures. The program is easy to use, but does require an understanding of mineralogy, of X-ray diffraction practice, and an elementary knowledge of the Excel program.

Implementation of Best Practices in Obesity Prevention in Child Care Facilities: The Arizona Empower Program, 2013–2015

PubMed Central

Papa, Jillian; Rodriguez, Gertrudes; Robinson, Deborah

2017-01-01

Introduction Obesity is a major health concern in every US age group. Approximately one in 4 children in Arizona’s Special Supplemental Nutrition Program for Women, Infants, and Children is overweight or obese. The Arizona Department of Health Services developed the Empower program to promote healthy environments in licensed child care facilities. The program consists of 10 standards, including one standard for each of these 5 areas: physical activity and screen time, breastfeeding, fruit juice and water, family-style meals, and staff training. The objective of this evaluation was to determine the level of implementation of these 5 Empower standards. Methods A self-assessment survey was completed from July 2013 through June 2015 by 1,850 facilities to evaluate the level of implementation of 5 Empower standards. We calculated the percentage of facilities that reported the degree to which they implemented each standard and identified common themes in comments recorded in the survey. Results All facilities reported either full or partial implementation of the 5 standards. Of 1,678 facilities, 21.7% (n = 364) reported full implementation of all standards, and 78.3% (n = 1,314) reported at least partial implementation. Staff training, which has only one component, had the highest level of implementation: 77.4% (n = 1,299) reported full implementation. Only 44.0% (n = 738) reported full implementation of the standard on a breastfeeding-friendly environment. Conclusion Arizona child care facilities have begun to implement the Empower program, but facilities will need more education, technical assistance, and support in some areas to fully implement the program. PMID:28880840

Implementation of Best Practices in Obesity Prevention in Child Care Facilities: The Arizona Empower Program, 2013-2015.

PubMed

Papa, Jillian; Agostinelli, Joan; Rodriguez, Gertrudes; Robinson, Deborah

2017-09-07

Obesity is a major health concern in every US age group. Approximately one in 4 children in Arizona's Special Supplemental Nutrition Program for Women, Infants, and Children is overweight or obese. The Arizona Department of Health Services developed the Empower program to promote healthy environments in licensed child care facilities. The program consists of 10 standards, including one standard for each of these 5 areas: physical activity and screen time, breastfeeding, fruit juice and water, family-style meals, and staff training. The objective of this evaluation was to determine the level of implementation of these 5 Empower standards. A self-assessment survey was completed from July 2013 through June 2015 by 1,850 facilities to evaluate the level of implementation of 5 Empower standards. We calculated the percentage of facilities that reported the degree to which they implemented each standard and identified common themes in comments recorded in the survey. All facilities reported either full or partial implementation of the 5 standards. Of 1,678 facilities, 21.7% (n = 364) reported full implementation of all standards, and 78.3% (n = 1,314) reported at least partial implementation. Staff training, which has only one component, had the highest level of implementation: 77.4% (n = 1,299) reported full implementation. Only 44.0% (n = 738) reported full implementation of the standard on a breastfeeding-friendly environment. Arizona child care facilities have begun to implement the Empower program, but facilities will need more education, technical assistance, and support in some areas to fully implement the program.

45 CFR 170.299 - Incorporation by reference.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Drug Programs Prescriber/Pharmacist Interface SCRIPT Standard, Implementation Guide, Version 8, Release.... (1) National Council for Prescription Drug Programs Prescriber/Pharmacist Interface SCRIPT Standard...

40 CFR 192.33 - Corrective action programs.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Corrective action programs. 192.33 Section 192.33 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION PROTECTION PROGRAMS HEALTH AND ENVIRONMENTAL PROTECTION STANDARDS FOR URANIUM AND THORIUM MILL TAILINGS Standards for...

25 CFR 10.1 - Why are policies and standards needed for Indian country detention programs?

Code of Federal Regulations, 2010 CFR

2010-04-01

... programs under the Indian Alcohol and Substance Abuse Prevention and Treatment Act, Public Law 99-570, (25... detention programs? 10.1 Section 10.1 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER INDIAN COUNTRY DETENTION FACILITIES AND PROGRAMS § 10.1 Why are policies and standards needed for...

25 CFR 10.1 - Why are policies and standards needed for Indian country detention programs?

Code of Federal Regulations, 2011 CFR

2011-04-01

... programs under the Indian Alcohol and Substance Abuse Prevention and Treatment Act, Public Law 99-570, (25... detention programs? 10.1 Section 10.1 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER INDIAN COUNTRY DETENTION FACILITIES AND PROGRAMS § 10.1 Why are policies and standards needed for...

25 CFR 10.1 - Why are policies and standards needed for Indian country detention programs?

Code of Federal Regulations, 2013 CFR

2013-04-01

... programs under the Indian Alcohol and Substance Abuse Prevention and Treatment Act, Public Law 99-570, (25... detention programs? 10.1 Section 10.1 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER INDIAN COUNTRY DETENTION FACILITIES AND PROGRAMS § 10.1 Why are policies and standards needed for...

25 CFR 10.1 - Why are policies and standards needed for Indian country detention programs?

Code of Federal Regulations, 2012 CFR

2012-04-01

... programs under the Indian Alcohol and Substance Abuse Prevention and Treatment Act, Public Law 99-570, (25... detention programs? 10.1 Section 10.1 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER INDIAN COUNTRY DETENTION FACILITIES AND PROGRAMS § 10.1 Why are policies and standards needed for...

25 CFR 10.1 - Why are policies and standards needed for Indian country detention programs?

Code of Federal Regulations, 2014 CFR

2014-04-01

... programs under the Indian Alcohol and Substance Abuse Prevention and Treatment Act, Public Law 99-570, (25... detention programs? 10.1 Section 10.1 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER INDIAN COUNTRY DETENTION FACILITIES AND PROGRAMS § 10.1 Why are policies and standards needed for...

A Program Evaluation of a Seminar Program

ERIC Educational Resources Information Center

Lyons, Robert Dale, Jr.

2013-01-01

When students do not score well on standardized tests, their school can suffer. In an attempt to improve standardized test scores, a district placed students into a program called Seminar to help them work on weak areas of content through personalized instruction. The purpose of this project study was to assess if the Seminar program had a…

45 CFR 2516.840 - By what standards will the Corporation evaluate individual Learn and Serve America programs?

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 4 2012-10-01 2012-10-01 false By what standards will the Corporation evaluate individual Learn and Serve America programs? 2516.840 Section 2516.840 Public Welfare Regulations Relating to... Learn and Serve America programs? The Corporation will evaluate programs based on the following: (a) The...

45 CFR 2516.840 - By what standards will the Corporation evaluate individual Learn and Serve America programs?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 4 2011-10-01 2011-10-01 false By what standards will the Corporation evaluate individual Learn and Serve America programs? 2516.840 Section 2516.840 Public Welfare Regulations Relating to... Learn and Serve America programs? The Corporation will evaluate programs based on the following: (a) The...

45 CFR 2516.840 - By what standards will the Corporation evaluate individual Learn and Serve America programs?

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 4 2013-10-01 2013-10-01 false By what standards will the Corporation evaluate individual Learn and Serve America programs? 2516.840 Section 2516.840 Public Welfare Regulations Relating to... Learn and Serve America programs? The Corporation will evaluate programs based on the following: (a) The...

45 CFR 2516.840 - By what standards will the Corporation evaluate individual Learn and Serve America programs?

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 4 2014-10-01 2014-10-01 false By what standards will the Corporation evaluate individual Learn and Serve America programs? 2516.840 Section 2516.840 Public Welfare Regulations Relating to... Learn and Serve America programs? The Corporation will evaluate programs based on the following: (a) The...

ETV Program Report: Coatings for Wastewater Collection Systems - Standard Cement Materials, Epoxy Coating 4553

EPA Science Inventory

The Standard Cement Materials, Inc. Standard Epoxy Coating 4553™ (SEC 4553) epoxy coating used for wastewater collection system rehabilitation was evaluated by EPA’s Environmental Technology Verification Program under laboratory conditions at the Center for Innovative Grouting Ma...

ICT Competency Standards for Teachers: Competency Standards Modules

ERIC Educational Resources Information Center

United Nations Educational, Scientific and Cultural Organization (UNESCO), 2008

2008-01-01

Both professional development programs for teachers currently in the classroom and programs for preparing future teachers should provide technology-rich experiences throughout all aspects of the training. Standards and resources within the United Nations Educational, Scientific, and Cultural Organization (UNESCO)'s project "Information and…

Integrated flexible manufacturing program for manufacturing automation and rapid prototyping

NASA Technical Reports Server (NTRS)

Brooks, S. L.; Brown, C. W.; King, M. S.; Simons, W. R.; Zimmerman, J. J.

1993-01-01

The Kansas City Division of Allied Signal Inc., as part of the Integrated Flexible Manufacturing Program (IFMP), is developing an integrated manufacturing environment. Several systems are being developed to produce standards and automation tools for specific activities within the manufacturing environment. The Advanced Manufacturing Development System (AMDS) is concentrating on information standards (STEP) and product data transfer; the Expert Cut Planner system (XCUT) is concentrating on machining operation process planning standards and automation capabilities; the Advanced Numerical Control system (ANC) is concentrating on NC data preparation standards and NC data generation tools; the Inspection Planning and Programming Expert system (IPPEX) is concentrating on inspection process planning, coordinate measuring machine (CMM) inspection standards and CMM part program generation tools; and the Intelligent Scheduling and Planning System (ISAPS) is concentrating on planning and scheduling tools for a flexible manufacturing system environment. All of these projects are working together to address information exchange, standardization, and information sharing to support rapid prototyping in a Flexible Manufacturing System (FMS) environment.

Identifying Strategies Programs Adopt to Meet Healthy Eating and Physical Activity Standards in Afterschool Programs.

PubMed

Weaver, Robert G; Moore, Justin B; Turner-McGrievy, Brie; Saunders, Ruth; Beighle, Aaron; Khan, M Mahmud; Chandler, Jessica; Brazendale, Keith; Randell, Allison; Webster, Collin; Beets, Michael W

2017-08-01

The YMCA of USA has adopted Healthy Eating and Physical Activity (HEPA) Standards for its afterschool programs (ASPs). Little is known about strategies YMCA ASPs are implementing to achieve Standards and these strategies' effectiveness. (1) Identify strategies implemented in YMCA ASPs and (2) evaluate the relationship between strategy implementation and meeting Standards. HEPA was measured via accelerometer (moderate-to-vigorous-physical-activity [MVPA]) and direct observation (snacks served) in 20 ASPs. Strategies were identified and mapped onto a capacity building framework ( Strategies To Enhance Practice [STEPs]). Mixed-effects regression estimated increases in HEPA outcomes as implementation increased. Model-implied estimates were calculated for high (i.e., highest implementation score achieved), moderate (median implementation score across programs), and low (lowest implementation score achieved) implementation for both HEPA separately. Programs implemented a variety of strategies identified in STEPs. For every 1-point increase in implementation score 1.45% (95% confidence interval = 0.33% to 2.55%, p ≤ .001) more girls accumulated 30 min/day of MVPA and fruits and/or vegetables were served on 0.11 more days (95% confidence interval = 0.11-0.45, p ≤ .01). Relationships between implementation and other HEPA outcomes did not reach statistical significance. Still regression estimates indicated that desserts are served on 1.94 fewer days (i.e., 0.40 vs. 2.34) in the highest implementing program than the lowest implementing program and water is served 0.73 more days (i.e., 2.37 vs. 1.64). Adopting HEPA Standards at the national level does not lead to changes in routine practice in all programs. Practical strategies that programs could adopt to more fully comply with the HEPA Standards are identified.

Standards for Quality Programs in Agricultural Occupations in the Secondary Schools and Area Vocational Centers of Illinois. Phase II. A Progress Report.

ERIC Educational Resources Information Center

Stitt, Thomas R.; And Others

The purpose of this project was to prepare materials to be used in the review and evaluation of an agricultural occupations program. Based on standards validated by Illinois agricultural occupations teachers, a standards workbook was developed that included standards specific to agricultural production, agricultural sales and service, agricultural…

Application of IUS equipment and experience to orbit transfer vehicles of the 90's

NASA Astrophysics Data System (ADS)

Bangsund, E.; Keeney, J.; Cowgill, E.

1985-10-01

This paper relates experiences with the IUS program and the application of that experience to Future Orbit Transfer Vehicles. More specifically it includes the implementation of the U.S. Air Force Space Division high reliability parts standard (SMASO STD 73-2C) and the component/system test standard (MIL-STD-1540A). Test results from the parts and component level testing and the resulting system level test program for fourteen IUS flight vehicles are discussed. The IUS program has had the highest compliance with these standards and thus offers a benchmark of experience for future programs demanding extreme reliability. In summary, application of the stringent parts standard has resulted in fewer failures during testing and the stringent test standard has eliminated design problems in the hardware. Both have been expensive in costs and schedules, and should be applied with flexibility.

76 FR 52350 - Vehicular Digital Multimedia Evidence Recording System (VDMERS) Standard, Certification Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-22

... DEPARTMENT OF JUSTICE Office of Justice Programs [OJP (NIJ) Docket No. 1564] Vehicular Digital Multimedia Evidence Recording System (VDMERS) Standard, Certification Program Requirements, and Selection and... three draft documents related to Vehicular Digital Multimedia Evidence Recording Systems (VDMERSs) used...

45 CFR 302.39 - Standards for program operation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 302.39 Public Welfare Regulations Relating to Public Welfare OFFICE OF CHILD SUPPORT ENFORCEMENT (CHILD SUPPORT ENFORCEMENT PROGRAM), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND... provide that the IV-D agency will comply with the standards for program operation and the organizational...

78 FR 79567 - National School Lunch Program and School Breakfast Program: Nutrition Standards for All Foods...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-31

... Program: Nutrition Standards for All Foods Sold in Schools as Required by the Healthy, Hunger-Free Kids... All Foods Sold in Schools as required by the Healthy, Hunger-Free Kids Act of 2010 was published on...

Contracting Officer Technical Representative Briefing

NASA Technical Reports Server (NTRS)

Gettleman, Alan

2001-01-01

This viewgraph presentation gives an overview of the Agency Occupational Health Program, including details on organizational and personnel changes, medical program standardization, programmatic status, policies, standards, and guides and resources, industrial hygiene and radiological health, assessment schedule and methodology, upcoming events, and the future of the program.

34 CFR 361.82 - Evaluation standards.

Code of Federal Regulations, 2011 CFR

2011-07-01

... with disabilities under the VR program. (b) A DSU must achieve successful performance on both evaluation standards during each performance period. (c) The evaluation standards for the VR program are— (1... equal access to VR services. (Approved by the Office of Management and Budget under control number 1820...

34 CFR 361.82 - Evaluation standards.

Code of Federal Regulations, 2010 CFR

2010-07-01

... with disabilities under the VR program. (b) A DSU must achieve successful performance on both evaluation standards during each performance period. (c) The evaluation standards for the VR program are— (1... equal access to VR services. (Approved by the Office of Management and Budget under control number 1820...

75 FR 38026 - Medicare Program; Identification of Backward Compatible Version of Adopted Standard for E...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-01

... Programs (NCPDP) Prescriber/ Pharmacist Interface SCRIPT standard, Implementation Guide, Version 10... Prescriber/Pharmacist Interface SCRIPT standard, Version 8, Release 1 and its equivalent NCPDP Prescriber/Pharmacist Interface SCRIPT Implementation Guide, Version 8, Release 1 (hereinafter referred to as the...

34 CFR 361.82 - Evaluation standards.

Code of Federal Regulations, 2012 CFR

2012-07-01

... with disabilities under the VR program. (b) A DSU must achieve successful performance on both evaluation standards during each performance period. (c) The evaluation standards for the VR program are— (1... equal access to VR services. (Approved by the Office of Management and Budget under control number 1820...

34 CFR 361.82 - Evaluation standards.

Code of Federal Regulations, 2013 CFR

2013-07-01

... with disabilities under the VR program. (b) A DSU must achieve successful performance on both evaluation standards during each performance period. (c) The evaluation standards for the VR program are— (1... equal access to VR services. (Approved by the Office of Management and Budget under control number 1820...

34 CFR 361.82 - Evaluation standards.

Code of Federal Regulations, 2014 CFR

2014-07-01

... with disabilities under the VR program. (b) A DSU must achieve successful performance on both evaluation standards during each performance period. (c) The evaluation standards for the VR program are— (1... equal access to VR services. (Approved by the Office of Management and Budget under control number 1820...

Illinois Occupational Skill Standards: Chemical Process Technical Operators.

ERIC Educational Resources Information Center

Illinois Occupational Skill Standards and Credentialing Council, Carbondale.

This document, which is intended for workforce preparation program providers, details the Illinois Occupational Skill Standards for programs preparing students for employment as chemical process technical operators. The document begins with a brief overview of the Illinois perspective on occupational skill standards and credentialing, the process…

Illinois Occupational Skill Standards: Automotive Technician Cluster.

ERIC Educational Resources Information Center

Illinois Occupational Skill Standards and Credentialing Council, Carbondale.

This document, which is intended as a guide for work force preparation program providers, details the Illinois occupational skill standards for programs preparing students for employment in occupations in the automotive technician cluster. The document begins with overviews of the Illinois perspective on occupational skill standards and…

77 FR 16769 - Energy Conservation Program for Certain Industrial Equipment: Energy Conservation Standards and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-22

... Conservation Program for Certain Industrial Equipment: Energy Conservation Standards and Test Procedures for...-Conditioning Engineers (ASHRAE)/Illuminating Engineering Society of North America (IESNA) Standard 90.1-2010... Industrial Equipment, which includes the commercial heating, air-conditioning, and water-heating equipment...

76 FR 57897 - Energy Conservation Program: Energy Conservation Standards for Certain External Power Supplies

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-19

... Energy Conservation Program: Energy Conservation Standards for Certain External Power Supplies AGENCY... external power supplies used in specific applications from certain energy conservation standards prescribed... external power supplies used either in security or life safety alarms or surveillance system components...

Colorado Model Content Standards: Foreign Language.

ERIC Educational Resources Information Center

Colorado State Dept. of Education, Denver.

The model course content standards for foreign language instruction in Colorado's public schools, K-12, provide guidelines, not curriculum, for school districts to design language programs. An introductory section presents some basic considerations in program design. The two general standards for foreign language performance are that: (1) students…

Creating Standards-Based Technology Education Facilities

ERIC Educational Resources Information Center

Daugherty, Michael K.; Klenke, Andrew M.; Neden, Michael

2008-01-01

One of the most intimidating tasks faced by new or practicing technology education teachers is the challenge of creating new facilities or renovating current facilities for a new purpose. While the fourth program standard in "Advancing Excellence in Technological Literacy: Student Assessment, Professional Development, and Program Standards (AETL)"…

Illinois Occupational Skill Standards. Meeting Professional Cluster.

ERIC Educational Resources Information Center

Illinois Occupational Skill Standards and Credentialing Council, Carbondale.

This document, which is intended as a guide for workforce preparation program providers, details the Illinois occupational skill standards for programs preparing students for employment in the meeting professional occupational cluster. It begins with a brief overview of the Illinois perspective on occupational skill standards and credentialing,…

Illinois Occupational Skill Standards. Beef Production Cluster.

ERIC Educational Resources Information Center

Illinois Occupational Skill Standards and Credentialing Council, Carbondale.

This document, which is intended as a guide for workforce preparation program providers, details the Illinois occupational skill standards for programs preparing students for employment in occupations in the beef production cluster. The document begins with a brief overview of the Illinois perspective on occupational skill standards and…

Standard spacecraft economic analysis. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

Harris, E. D.; Large, J. P.

1976-01-01

A study of the comparative program costs associated with use of various standardized spacecraft for Air Force space test program missions to be flown on the space shuttle during the 1980-1990 time period is reviewed. The first phase of the study considered a variety of procurement mixes composed of existing or programmed NASA standard spacecraft designs and a Air Force standard spacecraft design. The results were briefed to a joint NASA/Air Force audience on July 11, 1976. The second phase considered additional procurement options using an upgraded version of an existing NASA design. The results of both phases are summarized.

CSER-98-002: Criticality analysis for the storage of special nuclear material sources and standards in the WRAP facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

GOLDBERG, H.J.

1999-05-18

The Waste Receiving and Processing (WRAP) Facility will store uranium and transuranic (TRU) sources and standards for certification that WRAP meets the requirements of the Quality Assurance Program Plan (QAPP) for the Waste Isolation Pilot Plant (WIPP). In addition, WRAP must meet internal requirements for testing and validation of measuring instruments for nondestructive assay (NDA). In order to be certified for WIPP, WRAP will participate in the NDA Performance Demonstration Program (PDP). This program is a blind test of the NDA capabilities for TRU waste. It is intended to ensure that the NDA capabilities of this facility satisfy the requirementsmore » of the quality assurance program plan for the WIPP. The PDP standards have been provided by the Los Alamos National Laboratory (LANL) for this program. These standards will be used in the WRAP facility.« less

IFNA approved Chinese Anaesthesia Nurse Education Program: A Delphi method.

PubMed

Hu, Jiale; Fallacaro, Michael D; Jiang, Lili; Wu, Junyan; Jiang, Hong; Shi, Zhen; Ruan, Hong

2017-09-01

Numerous nurses work in operating rooms and recovery rooms or participate in the performance of anaesthesia in China. However, the scope of practice and the education for Chinese Anaesthesia Nurses is not standardized, varying from one geographic location to another. Furthermore, most nurses are not trained sufficiently to provide anaesthesia care. This study aimed to develop the first Anaesthesia Nurse Education Program in Mainland China based on the Educational Standards of the International Federation of Nurse Anaesthetists. The Delphi technique was applied to develop the scope of practice, competencies for Chinese Anaesthesia Nurses and education program. In 2014 the Anaesthesia Nurse Education Program established by the hospital applied for recognition by the International Federation of Nurse Anaesthetists. The Program's curriculum was evaluated against the IFNA Standards and recognition was awarded in 2015. The four-category, 50-item practice scope, and the three-domain, 45-item competency list were identified for Chinese Anaesthesia Nurses. The education program, which was established based on the International Federation of Nurse Anaesthetists educational standards and Chinese context, included nine curriculum modules. In March 2015, 13 candidates received and passed the 21-month education program. The Anaesthesia Nurse Education Program became the first program approved by the International Federation of Nurse Anaesthetists in China. Policy makers and hospital leaders can be confident that anaesthesia nurses graduating from this Chinese program will be prepared to demonstrate high level patient care as reflected in the recognition by IFNA of their adoption of international nurse anaesthesia education standards. Copyright © 2017 Elsevier Ltd. All rights reserved.

30 CFR 817.122 - Subsidence control: Public notice.

Code of Federal Regulations, 2010 CFR

2010-07-01

... INTERIOR PERMANENT PROGRAM PERFORMANCE STANDARDS PERMANENT PROGRAM PERFORMANCE STANDARDS-UNDERGROUND MINING... to all owners and occupants of surface property and structures above the underground workings. The...