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Sample records for strategic computing initiative

  1. National Strategic Computing Initiative Strategic Plan

    DTIC Science & Technology

    2016-07-01

    like sensing and problem - solving at low power.9 NIST and NSF have long supported research in quantum sensors and quantum communication . NIST, NSF, and...computational paradigms and the classes of problems they may efficiently solve ; and  Create and evaluate the measurement technologies necessary to assess... solve the most demanding DOE and NNSA mission problems ;  Provide research leadership in the development and use of next-generation HPC

  2. Computational Biology: A Strategic Initiative LDRD

    SciTech Connect

    Barksy, D; Colvin, M

    2002-02-07

    The goal of this Strategic Initiative LDRD project was to establish at LLNL a new core capability in computational biology, combining laboratory strengths in high performance computing, molecular biology, and computational chemistry and physics. As described in this report, this project has been very successful in achieving this goal. This success is demonstrated by the large number of referred publications, invited talks, and follow-on research grants that have resulted from this project. Additionally, this project has helped build connections to internal and external collaborators and funding agencies that will be critical to the long-term vitality of LLNL programs in computational biology. Most importantly, this project has helped establish on-going research groups in the Biology and Biotechnology Research Program, the Physics and Applied Technology Directorate, and the Computation Directorate. These groups include three laboratory staff members originally hired as post-doctoral researchers for this strategic initiative.

  3. Delivering Insight The History of the Accelerated Strategic Computing Initiative

    SciTech Connect

    Larzelere II, A R

    2007-01-03

    The history of the Accelerated Strategic Computing Initiative (ASCI) tells of the development of computational simulation into a third fundamental piece of the scientific method, on a par with theory and experiment. ASCI did not invent the idea, nor was it alone in bringing it to fruition. But ASCI provided the wherewithal - hardware, software, environment, funding, and, most of all, the urgency - that made it happen. On October 1, 2005, the Initiative completed its tenth year of funding. The advances made by ASCI over its first decade are truly incredible. Lawrence Livermore, Los Alamos, and Sandia National Laboratories, along with leadership provided by the Department of Energy's Defense Programs Headquarters, fundamentally changed computational simulation and how it is used to enable scientific insight. To do this, astounding advances were made in simulation applications, computing platforms, and user environments. ASCI dramatically changed existing - and forged new - relationships, both among the Laboratories and with outside partners. By its tenth anniversary, despite daunting challenges, ASCI had accomplished all of the major goals set at its beginning. The history of ASCI is about the vision, leadership, endurance, and partnerships that made these advances possible.

  4. Accelerated Strategic Computing Initiative (ASCI) Program Plan [FY2000

    SciTech Connect

    2000-01-01

    In August 1995, the United States took a significant step to reduce the nuclear danger. The decision to pursue a zero- yield Comprehensive Test Ban Treaty will allow greater control over the proliferation of nuclear weapons and will halt the growth of new nuclear systems. This step is only possible because of the Stockpile Stewardship Program, which provides an alternative means of ensuring the safety, performance, and reliability of the United States' enduring stockpile. At the heart of the Stockpile Stewardship Program is ASCI, which will create the high-confidence simulation capabilities needed to integrate fundamental science, experiments, and archival data into the stewardship of the actual weapons in the stockpile. ASCI will also serve to drive the development of simulation as a national resource by working closely with the computer industry and with universities.

  5. Properties of energetic materials: United States Department of Energy (DOE) Accelerated Strategic Computing Initiative (ASCI) strategic alliances

    SciTech Connect

    Adams, T.F.

    1997-01-01

    The Accelerated Strategic Computing Initiative (ASCI) program is designed to provide the computational resources which are required to provide a simulation based approach to the Science Based Stockpile Stewardship (SBSS) program. The capability to predict the properties of energetic materials is one of the areas of interest to the US Department of Energy`s (DOE) ASCI program. This capability will support computational assessments of the safety and reliability of systems containing explosives and other energetic materials subjected to normal and abnormal environments. Several research elements related to energetic material properties are described in more detail below. They are: (A) calculation of decomposition rates, (B) molecular potential functions, (C) physical properties and transport coefficients, (D) molecular energization mechanisms, (E) fracture/failure of energetic material crystals, (F) grain-grain and grain- binder interactions, and (G) aging effects in energetic material. These elements have in common the need to develop computational methods that have a strong foundation in basic physical principles. They will generally have to be implemented to run efficiently on advanced parallel computing platforms to achieve sufficient accuracy.

  6. DOE accelerated strategic computing initiative: challenges and opportunities for predictive materials simulation capabilities

    SciTech Connect

    Mailhiot, C.

    1997-10-01

    In response to the unprecedented national security challenges derived from the end of nuclear testing, the Defense Programs of the Department of Energy has developed a long-term strategic plan based on a vigorous Science-Based Stockpile Stewardship (SBSS) program. The main objective of the SBSS program is to ensure confidence in the performance, safety, and reliability of the stockpile on the basis of a fundamental science-based approach. A central element of this approach is the development of predictive, full-physics, full-scale computer simulation tools. As a critical component of the SBSS program, the Accelerated Strategic Computing Initiative (ASCI) was established to provide the required advances in computer platforms and to enable predictive, physics-based simulation technologies. Foremost among the key elements needed to develop predictive simulation capabilities, the development of improved physics-based materials models has been universally identified as one of the highest-priority, highest-leverage activity. We indicate some of the materials modeling issues of relevance to stockpile materials and illustrate how the ASCI program will enable the tools necessary to advance the state-of-the-art in the field of computational condensed matter and materials physics.

  7. Cooperative high-performance storage in the accelerated strategic computing initiative

    NASA Technical Reports Server (NTRS)

    Gary, Mark; Howard, Barry; Louis, Steve; Minuzzo, Kim; Seager, Mark

    1996-01-01

    The use and acceptance of new high-performance, parallel computing platforms will be impeded by the absence of an infrastructure capable of supporting orders-of-magnitude improvement in hierarchical storage and high-speed I/O (Input/Output). The distribution of these high-performance platforms and supporting infrastructures across a wide-area network further compounds this problem. We describe an architectural design and phased implementation plan for a distributed, Cooperative Storage Environment (CSE) to achieve the necessary performance, user transparency, site autonomy, communication, and security features needed to support the Accelerated Strategic Computing Initiative (ASCI). ASCI is a Department of Energy (DOE) program attempting to apply terascale platforms and Problem-Solving Environments (PSEs) toward real-world computational modeling and simulation problems. The ASCI mission must be carried out through a unified, multilaboratory effort, and will require highly secure, efficient access to vast amounts of data. The CSE provides a logically simple, geographically distributed, storage infrastructure of semi-autonomous cooperating sites to meet the strategic ASCI PSE goal of highperformance data storage and access at the user desktop.

  8. Strategic Defense Initiative program

    SciTech Connect

    Conachan, F.C.

    1991-05-01

    This paper discusses the Strategic Defense Initiative (SDI) program. It summarizes the major programmatic and technological lessons learned from the SDI program over the past 7 years. It provides information on: past uses of SDI funds, persistent optimism in planning and starting projects, evolution of SDI architecture, and accuracy of cost estimates.

  9. Strategic Defense Initiative - strategic implications. Study project

    SciTech Connect

    Russell, T.L.

    1988-03-31

    In March 1983, during this address to the nation, President Reagan initiated a major shift in U.S. strategic policy, as he indicated his desire to move away from the condition of mutual vulnerability as the primary deterrent to nuclear war. The Strategic Defense Initiative (SDI), as the vehicle for this shift, has become the focus of debate over implications of a new strategic policy. This study seeks to examine the strategic relationship, and the role of arms control during a transition from an offensive-dominant strategy to a defensive-dominant strategy. The methodology for the study is to present arguments for and against SDI, as they relate to the issues of stability and arms control, evaluate their validity, draw conclusions, and provide recommendations that may enhance international security during a transition period of SDI.

  10. Strategic defense initiative

    SciTech Connect

    Nichols, J.P.

    1985-01-01

    The Engineering Technology Division has a leading role, including that of program management, in a major new programmatic thrust of the Oak Ridge National Laboratory that is in support of the national Strategic Defense Initiative (SDI). It is appropriate for the Laboratory to become significantly involved in the program because several of the most promising SDI technologies are in areas for which ORNL (together with Y-12 and K-25) have strong capabilities and significant resources. The initial ORNL work in support of the SDI program is focused on three technologies in which ORNL has extensive experience and traditionally strong research and development programs: (1) space nuclear power, (2) flywheel energy storage, and (3) neutral particle beams. The space nuclear program will utilize our capabilities in areas such as refractory materials, high-temperature alkali metal systems, shielding, and instrumentation. Space nuclear reactors capable of supplying multimegawatt levels of electrical power on a continuous and long-term basis are envisioned to be required for a variety of SDI surveillance satellites and space-borne weapons platforms. The feasibility of an alkali metal Rankine power conversion cycle, which has promise of providing high power with a very low system mass, is planned for study.

  11. Strategic Stability Through the Strategic Defense Initiative

    DTIC Science & Technology

    1989-03-09

    role of the Strategic Defense Initiative research program will play in current and future nuclear stability issues. It addresses the historical ...Defense Initiative,.research program will play in current and future nuclear stability issues. It addresses the historical policies that lead to the...approach to stability, marked a historic moment. The question to consider from his speech is whether technological breakthroughs alter our earlier

  12. System 2020 - Strategic Initiative

    DTIC Science & Technology

    2010-08-26

    Manufacturing   Enterprise   Resource   Planning   ( ERP )   systems   that   are   highly   integrated   and   difficult   to...news/government/cloud-­‐ saas /showArticle.jhtml?articleID=225200398&queryText=cloud%20computing  Accessed  on  June   25,  2010

  13. SDI (Strategic Defense Initiative): Myth or reality

    SciTech Connect

    Canavan, G.H.

    1988-06-01

    This report reviews previous attempts to develop strategic defenses, the technologies currently under consideration by the Strategic Defense Initiative (SDI), their main unknowns, and the likely performance of strategic defense concepts against evolving threats. 47 refs.

  14. Strategic Defense Initiative - an overview

    SciTech Connect

    Abrahamson, J.A.

    1985-01-01

    A general framework for developing the concept and implementing options for strategic ballistic missile defense systems is emerging. The objective of the Strategic Defense Initiative (SDI) program is to conduct research on those technologies for defensive system which could intercept ballistic missiles after they have been launched and prevent them from hitting their targets. Its goal is to acquire the technical knowledge as a basis for a later decision on deployment, not a program for deployment or star wars. Abrahamson reviews the basic technological questions facing researchers, outlines the multi-layered defense possibilities and summarizes the status of technology to date. He argues for a continuity of resources to conduct the program. 4 figures.

  15. Promise or Peril: The Strategic Defense Initiative.

    ERIC Educational Resources Information Center

    Brzezinski, Zbigniew, Ed.; And Others

    The major policy debate touched off by President Reagan's March 1983 speech announcing the Strategic Defense Initiative (SDI) was the reopening of one that had begun 35 years before. Then and now the ultimate question is what kind of strategic posture is most likely to contribute to mutual strategic stability? The answer is central to national…

  16. Strategic defense initiative: critical issues

    SciTech Connect

    Nuckolls, J.H.

    1985-06-01

    The objectives of the Strategic Defense Initiative (SDI) as outlined by President Reagan are discussed. The principal objective for SDI is as a defense against ballistic missiles. Soviet objections and a summary of US-USSR dialogue on the subject are reviewed. Most US studies have been critical of SDI. Four critical issues are addressed in depth: are defense weapons technologically feasible which have high economic leverage relative to offensive ballistic missiles; would the defense feasibility and leverage be degraded or enhanced in the technological race between weapons innovation and countermeasures; could stability be achieved during and after the transition to the defense dominated world envisioned by SDI proponents; would the deployment of high leverage defensive weapons increase or decrease the security of NATO Europe, and the probability of major conventional or nuclear wars. The issue of SDI may lead to a paradox that contains the seeds of catastrophe. The author concludes by warning that nuclear disarmament may eliminate the highly successful deterrent mechanism for avoiding another major world war. In a world made safe for major conventional wars by the apparent ''elimination'' of nuclear weapons, the leaders in a conventional World War III - involving unimaginable suffering, hatred, terror, and death - would be strongly motivated to introduce nuclear weapons in the crucial decisive battles. Even if diplomacy could ''eliminate'' nuclear weapons, man's knowledge of nuclear weapons can never be eliminated. The paradox is the attempt to eliminate nuclear weapons may maximize the probability of their use. (DMC)

  17. Evaluation of computer-aided system design tools for SDI (Strategic Defense Initiative) Battle Management/C3 (command, control and communications) architecture development. Final report

    SciTech Connect

    Fife, D.W.; Campbell, K.; Chludzinski, J.; Corcoran, N.; Gonzalez, C.

    1987-10-01

    This IDA paper was prepared at the request of the Strategic Defense Initiative Organization. The paper documents findings of an evaluation on the capabilities of certain computer software/computer-aided software engineering (CASE) tools to provide computer-aided graphic design of Battle Management/C3 for the SDIO. Each tool (of the five selected on the basis of the best available at this time), was installed at IDA. After training by vendor tool staff, an IDA team, using a hands-on design experience determined the merits of the tools for SDI application. A comparative summary of the tools is given relative to envisaged SDI requirements and an extensive questionnaire is answered for each.

  18. Philosophical Scrutiny of the Strategic Defense Initiatives.

    ERIC Educational Resources Information Center

    Schonsheck, Jonathan

    1986-01-01

    Analyzes three Strategic Defense Initiative (SDI) proposals, and argues that only the least technologically feasible variant (the AstroAtmosOceanDome conception) can be judged morally superior to old-fashioned "we'll kill you if you kill us" deterrence ideas. (JDH)

  19. Strategic Defense Initiative Fact Book.

    DTIC Science & Technology

    1986-09-01

    Cuban "missile crisis" that then-Secretary of Defense Robert McNamara and then-Assistant Secretary Harold Brown initiated our long-standing policy of...I § « ra w S3 BOA w tn o E Is . S 3 i • ,0) C?3 O »■a!S « «I g ■o S 1 tn ^ w o ** ■5 aim •*> j; — 1^ «j *^ [fly] 4» S i«:C5...about the venue and invited their ideas. ISSUE: SDI FUNDING CHARGE: Extensive allocations for SDI drains funding from other valuable research and

  20. Agenda for the strategic defense initiative

    SciTech Connect

    Kent, G.A.

    1988-01-01

    The goal of moving from an offense-dominated to a defense-dominated international strategic scene is desirable and feasible, and can best be achieved in cooperation with the U.S.S.R. Such a shared goal implies that deploying strategic defenses is clearly subordinate to the more encompassing matter of reducing ballistic missiles to zero or near zero. In addition to seeking Soviet cooperation, the U.S. should continue to discuss the pros and cons of such a direction with its allies, continue to conduct the strategic defense initiative (SDI) technology program aimed at an earth-based defense with passive defense, and continue to adhere to the 1972 ABM treaty.

  1. Policy implications of the Strategic Defense Initiative

    SciTech Connect

    Goodwin, R.C.

    1991-01-01

    Specific topics include: the technological feasibility of proposed components and architectures; the compatibility of the proposed systems with existing and proposed arms control agreements, with special emphasis upon the ABM Treaty, Outer Space Treaty, the Defense and Space Treaty, and the START Treaty; the compatibility of proposed systems with classical warfare doctrine and the four modern strategic nuclear doctrines of Massive Retaliation, Assured Destruction, Countervailing and Flexible Response; the economics of strategic defense including an assessment of overall governmental spending, of the suballocation for defense, and of the feasibility of defensive systems which are cost-effective at the margin; and, in summary, an assessment of the New Strategic Concept which balances arms control, offensive forces, and defensive forces. This study falls within the realm of defense policy analysis in that it attempts to determine whether the administration's proposed Strategic Defense Initiative, as well as the long-term strategic defensive systems derived from SDI research, constitute efficient, desirable allocation of scarce government resources - especially in a period of seemingly relaxed superpower tensions and numerous demands upon those resources.

  2. Health information technology: strategic initiatives, real progress.

    PubMed

    Kolodner, Robert M; Cohn, Simon P; Friedman, Charles P

    2008-01-01

    We fully agree with Carol Diamond and Clay Shirky that deployment of health information technology (IT) is necessary but not sufficient for transforming U.S. health care. However, the recent work to advance health IT is far from an exercise in "magical thinking." It has been strategic thinking. To illustrate this, we highlight recent initiatives and progress under four focus areas: adoption, governance, privacy and security, and interoperability. In addition, solutions exist for health IT to advance rapidly without adversely affecting future policy choices. A broad national consensus is emerging in support of advancing health IT to enable the transformation of health and care.

  3. Strategic defense initiative and western security

    SciTech Connect

    Elliot, S.R.

    1985-09-01

    The technological and political aspects of the Strategic Defense Initiative (SDI) affect East-West relations and transatlantic interalliance relations as well as impinging on each other. The Soviets could elect to use other technology, develop a large number of smaller missiles, or provide their own SDI system in response. Because of the high cost in skilled manpower and technology resources and a crisis in the domestic economy, the Soviets prefer to avoid an intensified arms race. There is concern that new technology will further widen the perceived electronic gap between Europe, on the one hand, and the US and Japan, on the other. Strategists in Europe ask if SDI will decouple transatlantic links. Some Europeans see the need for a voice in the ultimate discussions over deployment as a compelling reason to participate actively in the SDI program. Patience and good will are essential to keep links open to both Europe and the Warsaw Pact.

  4. SDI (Strategic Defense Initiative): a policy analysis

    SciTech Connect

    Fought, S.O.

    1987-01-01

    Contents include -- Foundations of Deterrence; A Model for Stability; Analysis of SDI/Stability; Related Issues; Treatment of Implementation Factors; Historical Evolution and Trends; The Strategic Choices and Flexible Response; The Planners' Perspective; The Impact of Strategic Defense on a Strategy of Flexible Response; Synthesis.

  5. Student Papers on Strategic Defense Initiative.

    DTIC Science & Technology

    1985-01-01

    Papers Page Considering Countermeasures 1 The Free Electron Laser for BMD 13 Antimatter : A Viable Option? 22 An Analysis of the Cost...Robinson, Arthur L. "A Visible Free Electron Laser In France." Science, 221 (September 2, 1983), 937-939. - 21 - ANTIMATTER : A VIABLE SDI...OPTION? by Cadet Jeffrey S. Henry 4 March 1985 - 22 - ANTIMATTER : A VIABLE SDI OPTION? On 23 March 1983 President Reagan submitted his Strategic

  6. SDI (Strategic Defense Initiative): A Policy Analysis,

    DTIC Science & Technology

    1987-01-01

    34" warheads. For NL=i, because of defense, NAm; therefore, the planner must increase NL until the greatest lower bound (GLB) of the 9017 confidence ...of confidence that a given (presumably high) percentage of those targets will be destroyed. These conditions do not apply, of course, to attacks on...commit aggression with confidence ; further, there must always be time in a crisis to perform that rational calculation. In the strategic nuclear arena

  7. The first spin-offs from the strategic defense initiative

    NASA Astrophysics Data System (ADS)

    Dowling, John

    1988-04-01

    President Reagan's Strategic Defense Initiative (SDI) is a plan to make nuclear weapons impotent and obsolete. Physicists have a professional interest in such a program because SDI involves high-power lasers, x-ray lasers, particle beams, large astronomical mirrors, computers, increased space shuttle program, etc. SDI is of interest to physics teachers because there are many important physical problems that must be resolved before this defense system will work. In this article several problems that SDI needs to address are sketched. There is a short discussion of each problem, but no detailed solutions or answers. Physics teachers can use these problems to discuss the various aspects of SDI that are germane to ``Science and Society'' type physics courses.

  8. Health Care Provider Initiative Strategic Plan

    ERIC Educational Resources Information Center

    National Environmental Education & Training Foundation, 2012

    2012-01-01

    This document lays out the strategy for achieving the goals and objectives of NEETF's "Health Care Provider Initiative." The goal of NEETF's "Health Care Provider Initiative" is to incorporate environmental health into health professionals' education and practice in order to improve health care and public health, with a special emphasis on…

  9. DNA-based computing of strategic assignment problems.

    PubMed

    Shu, Jian-Jun; Wang, Qi-Wen; Yong, Kian-Yan

    2011-05-06

    DNA-based computing is a novel technique to tackle computationally difficult problems, in which computing time grows exponentially corresponding to problematic size. A strategic assignment problem is a typical nondeterministic polynomial problem, which is often associated with strategy applications. In this Letter, a new approach dealing with strategic assignment problems is proposed based on manipulating DNA strands, which is believed to be better than the conventional silicon-based computing in solving the same problem.

  10. Technology Applications Program, SDI, Strategic Defense Initiative

    DTIC Science & Technology

    2007-11-02

    6. Developments in High-Energy Physics Used for Cancer Therapy 15 C. SDI SPINOFFS IN COMPUTER TECHNOLOGY j5 1. Introduction 2. A New Generation...materi- als for thermal and photochemical reactions and by biophysicists to study the physiological responses of biological materials. 3...research; eye surgery; materials that produce lighter, stronger leg braces; and cancer therapy . 2. Lasers in Medicine SDI laser work is yielding

  11. Crew and Thermal Systems Strategic Communications Initiatives in Support of NASA's Strategic Goals

    NASA Technical Reports Server (NTRS)

    Paul, Heather L.

    2012-01-01

    NASA has defined strategic goals to invest in next-generation technologies and innovations, to inspire students to become the future leaders of space exploration, and to expand partnerships with industry and academia around the world. The Crew and Thermal Systems Division (CTSD) at the NASA Johnson Space Center actively supports these NASA initiatives. In July 2011, CTSD created a strategic communications team to communicate CTSD capabilities, technologies, and personnel to internal NASA and external technical audiences for business development and collaborative initiatives, and to students, educators, and the general public for education and public outreach efforts. This paper summarizes the CTSD Strategic Communications efforts and metrics through the first nine months of fiscal year 2012.

  12. Crew and Thermal Systems Strategic Communications Initiatives in Support of NASA's Strategic Goals

    NASA Technical Reports Server (NTRS)

    Paul, Heather L.; Lamberth, Erika Guillory; Jennings, Mallory A.

    2012-01-01

    NASA has defined strategic goals to invest in next-generation technologies and innovations, inspire students to become the future leaders of space exploration, and expand partnerships with industry and academia around the world. The Crew and Thermal Systems Division (CTSD) at the NASA Johnson Space Center actively supports these NASA initiatives. In July 2011, CTSD created a strategic communications team to communicate CTSD capabilities, technologies, and personnel to external technical audiences for business development and collaborative initiatives, and to students, educators, and the general public for education and public outreach efforts. This paper summarizes the CTSD Strategic Communications efforts and metrics through the first half of fiscal year 2012 with projections for end of fiscal year data.

  13. President's Report on Strategic Action Areas and Initiatives, April, 2002.

    ERIC Educational Resources Information Center

    American Association of Community Colleges, Washington, DC.

    This paper outlines the strategic action areas and initiatives of the American Association of Community Colleges (AACC) for 2002. The six action areas outlined are: (1) national and international recognition and advocacy for community colleges; (2) learning and accountability; (3) leadership development; (4) economic and workforce development; (5)…

  14. Role of scientific advisers in the Strategic Defense Initiative

    SciTech Connect

    Lee, K.D.

    1986-01-01

    This paper compares the strategic and technical debate about the Strategic Defense Initiative (SDI) to the ABM debate of 1968-1972. One major difference is the commitment of the President to support SDI; those who apparently influenced the President on this matter came from outside the ranks of his usual military and diplomatic advisers. In Congress, science advisers are less influential now than they were in the past, due to the strengthening of Congressional staffs and agencies, the growth of scientific interest groups, and the diminished novelty of their appearances in Congress. In light of the history of the ABM, the US should be careful to ensure that the financial and technical commitments to SDI do not automatically imply a commitment to deploy a strategic defense system.

  15. Strategic Defense Initiative, a chronology: 1983-1988

    SciTech Connect

    Not Available

    1988-01-01

    Since President Reagan announced his commitment to explore intensively the promise of new technologies for defense against ballistic missile attack, the Strategic Defense Initiative has evolved into a vigorous RandD program involving a number of U.S. allies. The objective of SDI is to strengthen U.S. and allied security and enhance long-term strategic stability. SDI is an integral part of U.S. and Soviet nuclear arsenals. It also has important potential benefits for spinoffs to other defense programs and for the development of technologies with potentially far reaching applications in the civilian sector. This report provides a chronology that highlights key points in the evolution of U.S. strategic defense policy since March 1983.

  16. Deterrence enhanced by SDI (Strategic Defense Initiative). Student essay

    SciTech Connect

    Sowa, P.T.

    1987-03-23

    The Strategic Defense Initiative (SDI) is an investigation by scientists, military leaders, and technologists of the feasibility of strategic defenses against ballistic missiles. Whether strategic defense is the way to go in the future remains to be seen. Although the capability of the envisioned layered, ground, and space-based defensive systems is not specifically addressed, the SDI research program's affect on national-security strategy and its formulation is examined. If found to be feasible and cost-effective, SDI will require a drastic change in our military strategy. This essay reviews how that strategy was formulated in the past in terms of a model and how strategic-defense strategy would be used in the future. More importantly, a discussion of how the SDI impacts on present US national strategy and enhances deterrence is presented. Its influence on technology, conventional defense, and arms controls are offered on this evolving strategic concept and the renewed vigor and interest it has provided in strategy formulation.

  17. Strategic defense initiatives at Los Alamos National Laboratory

    SciTech Connect

    Rockwood, S.D.

    1985-01-01

    This presentation reviews the Strategic Defense Initiative (SDI) programs at Los Alamos National Laboratory, noting especially the needs for and applications of optics and optical technologies. Table I lists the various activities at Los Alamos contributing to SDI programs. The principal, nonnuclear SDI programs are: (1) the free-electron laser, and (2) neutral particle beams. Both should be considered as potential long-range-kill systems, but still in the futuristic category.

  18. A Guide to International Participation in the Strategic Defense Initiative

    DTIC Science & Technology

    2007-11-02

    SDI 15 4 . HELPFUL HINTS IN DEALING 20 WITH SDI 5. SDI CONTRACTING ACTIVITIES 25 6. PROCEDURES AND REGULATIONS 37 7. SDIO-SPONSORED...of initial strategic defenses. Brilliant Eyes Ground-based Surveillance And Tracking Systenj (GSTS),’, Evolving Architectures Page 4 ALLIED...contacts between foreign embassies, governments, and industries and the technical and contracting offices in SDIO. Page 7 o H 2. =r 2 0

  19. EnviroNET: Space environment for Strategic Defense Initiative experiments

    NASA Technical Reports Server (NTRS)

    Lauriente, Michael

    1989-01-01

    EnviroNET is an operational system available to the Strategic Defense Initiative (SDI) experimenters who have access to a terminal or dial-up port. It is a tail node on Space Physics Analysis Network (SPAN) accessible directly or through the national networks via NPSS. Some of the benefits to using EnviroNET include: validated NASA environmental information and interactive space models; facilitating the payload integration process; easy access to expert assistance; and potential for time and cost savings.

  20. The Role of System Architecture in the Strategic Defense Initiative.

    DTIC Science & Technology

    1986-05-01

    pp. 76-81. Lin, Herbert, "The BMD Debate: Deja Vu ", DISCOVER, September 1985, pp. 50-51. Lin, Herbert, "The Software for Star Wars: An Achilles Heel...ARCHITECTURE IN THE STRATEGIC DEFENSE INITIATIVE DTIC SELECTED ~9E ~ UNIVERSITY (f PENNSYLVANLI PHILADELPHIA, PENNSYLVANIA 19104 pu ,-.-- mmna,,,,,.,,. I,2...Systems Engineering, School of Engineering and Applied Science, University of Pennsylvania. !Xgr pu4jjl ro~wvr- 4z’A VVIO. Do p *- ISECURITY

  1. 78 FR 69462 - National Nanotechnology Initiative Strategic Plan; National Science and Technology Council...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-19

    ... TECHNOLOGY POLICY OFFICE National Nanotechnology Initiative Strategic Plan; National Science and Technology Council; National Nanotechnology Coordination Office AGENCY: Executive Office of the President, Office of... requests public comments on the draft 2014 National Nanotechnology Initiative (NNI) Strategic Plan. The...

  2. Report to the Congress on the Strategic Defense Initiative, 1989

    SciTech Connect

    Not Available

    1989-03-13

    This report summarizes the SDI legacy of President Reagan, who launched the initiative with his speech of March 23, 1983. It describes in detail that current assessment of the best program for the resolution of remain technical issues, the validation of technologies, and the demonstration of the ability to integrate them. This program of research, development and testing would, if adequately funded, support a fully informed decision by the President and Congress in the future on whether to deploy a strategic defense of the United States. Such defenses could enhance deterrence and increase stability. In an effort to reduce the overall costs of a first-phase Strategic Defense System, the DOD recently completed an intensive review of the modifications made to date toward this end. The projected cost of the first phase of a Strategic Defense system has been reduced dramatically from the earlier estimate of $115 billion to $69 billion while maintaining the capability to contribute to deterrence. The review also confirmed that SDI is proceeding in the right direction toward development of a comprehensive space and ground-based Strategic Defense System.

  3. The Strategic Defense Initiative: New perspectives on deterrence

    SciTech Connect

    Dallmeyer, D.G.

    1986-01-01

    The Strategic Defense Initiative has evolved into a massively funded research and development effort with profound implications not only for weapons technology but also for East-West relations. In this book, preeminent figures from the policymaking and defense communities address critical aspects of the program, offering widely divergent points of view. Some contributors view SDI as the best way to develop alternatives to the strategy of retaliation by strengthening defensive deterrence, and they decry political reluctance to proceed with deployment. Others cite what they argue are virtually insurmountable technological obstacles to developing a ''perfect'' defense. They believe SDI will mean the end of arms control and an escalation of superpower competition in both offensive and defensive weapons. Some contributors look at the foreign policy perspectives, examining the fear of our NATO allies that SDI represents a progressive decoupling of the U.S. strategic deterrent from the defense of Europe. But as a counterpoint, some argue that SDI is not a doctrinal revolution in American strategic policy but rather a way to gain leverage over the Soviet strategic arsenal.

  4. Material Strength at High Pressure LDRD Strategic Initiative Final Report

    SciTech Connect

    Lassila, D H; Bonner, B P; Bulatov, V V; Cazamias, J U; Chandler, E A; Farber, D L; Moriarty, J A; Zaug, J M

    2004-03-02

    Various aspects of the Laboratory's national security mission are now highly dependent on accurate computer code simulations of plastic flow (i.e., non-reversible deformation) of materials under conditions of high hydrostatic pressure. Strength models are typically dependent on pressure, temperature, and strain rate. Current strength models can not be extrapolated to high pressure because they are not based on the underlying mechanisms of plastic deformation. The critical need for predictive models of material strength, which describe flow stress in computer code simulations, has motivated LLNL's multiscale modeling efforts. Over the past three years, the ''Material Strength at High Pressure'' LDRD Strategic Initiative has established a framework for the development of predictive strength models for deformation of metals under conditions of high hydrostatic pressure. Deformation experiments have been developed to measure the effect of high pressure on the yield strength and work hardening behavior of high purity Mo and Ta single crystals. The over arching goal of the SI is to experimentally validate multiscale-modeling capabilities for deformation of metals under conditions of high pressure. The work performed and accomplished is a necessary next step in the development of predictive strength models. Our initial experimental results show that the influence of pressure is to dramatically increase the work hardening rate of Ta. Bridgman also observed this in experiments performed in the 1950's. Currently there is very little modern data on this phenomena, or theoretical understanding. The work started by this SI is a first step in a comprehensive understanding of plasticity under conditions of high pressure and we expect eventually to be able to incorporate the proper physics into dislocation dynamics (DD) simulations to capture the increase in work hardening that we observe experimentally. In the following sections we briefly describe the work that was performed in

  5. Whither SDI (Strategic Defensive Initiative): Strategic defenses in the next administration

    SciTech Connect

    Kanter, A.

    1988-09-01

    This document examines the legacy of strategic defenses the next president will inherit from the Reagan administration. Concentrating on SDI, it describes the programmatic, budgetary, arms control, and political contours of the strategic defense agenda that the new president is likely to confront. It then considers the options he will face and plots a course he should take. This essay is intended to stimulate and structure debate about the future of strategic defenses. An earlier version of this paper was prepared for a Council on Foreign Relations study group on the Arms Control Agenda of the Next Administration. Since it was initially drafted in spring 1988, the politics of SDI have changed with a speed that few could have predicted. Abruptly and unexpectedly, SDI all but disappeared from the political debate at precisely the time when a multitude of candidates were vying for their parties' nominations, and then the two nominees were seeking to define and distinguish their positions. Despite these changed circumstances, this document should be of interest to those who are concerned with how developments in strategic defense bear on nuclear policy, programs, and arms control.

  6. JGI Computing 5-Year Strategic Plan

    SciTech Connect

    Bader, D A; Brettin, T S; Cottingham, R W; Folta, P A; Golder, Y; Gregurick, S K; Himmel, M E; Mann, R C; Remington, K A; Slezak, T R

    2008-10-01

    A broad range of scientific goals and a similarly diverse set of consumers drive the informatics requirements and computing needs of the JGI. The scope of work in this area encompasses not only the informatics and analysis pipelines in support of the PGF sequence production, but also the integration of data from a variety of sources and sophisticated large scale analyses led by investigators within JGI and driven by the user science community. In laying out a forward looking strategy, the full range of these activities need to be examined together to build a comprehensive program that will serve as a catalyst for the DOE research community. The science landscape envisioned in the overall strategic plan calls for significantly increasing the throughput of microbial genomes sequenced to cover their phylogenetic space and building a set of finished reference plant genomes to enable DOE relevant science. Additionally, the established impact of microbial communities on global energy cycles and their potential in remediation endeavors, warrant building upon JGI's established expertise in metagenomic analysis. Not only is each of these program areas relevant and exciting in their own right, but they also can and should be undertaken in a way that allows synthesis across domains (e.g. utilize knowledge from sequence of plants and the soil from which they are grown). Both dramatic increases in the scale of genomic data collection and the synergistic potential of integrating data across domains will demand new strategies in the informatics pipeline within the JGI and in the facility's approach to computational analysis and user access to the data in aggregated form. In addition to a robust and scalable informatics infrastructure, fulfilling the strategic science goals of the JGI will require ongoing investment in usability of the data, to ensure that the data collected will be used to maximal effect. It must be recognized that 'usability' will have a different appearance

  7. Strategic Defense Initiative in a changing world. Study project

    SciTech Connect

    Peacock, J.E.

    1992-03-16

    In response to dramatic changes in the global strategic environment, the United States must move from a bipolar to a multipolar defense strategy. Our emerging strategy must concentrate on both global and regional conflicts in which ballistic missiles of varying ranges and weapons of mass destruction may be employed. The proliferation of space and ballistic missile capabilities, especially into the Third World, will directly impact upon the future strategic defense requirements of the United States and its allies. The changing global geopolitical situation, along with technology proliferation, will require an effective ballistic missile defense through the Strategic Defense Initiative (SDI) Program, especially to defend against ballistic missile attack in regional conflict. More importantly, however, the changing global threat will considerably influence future arms-control regimes. This paper analyzes the emerging threat. It focuses on the growing threat posed by the proliferation of ballistic missiles and weapons of mass destruction and on proposed redirection of the SDI Program to adequately respond to the proliferation threat. Finally, it reviews how international arms-control regimes can be redirected from an East-West orientation to a broader global focus relative to missile proliferation.

  8. Strategic computing: a strategic plan for the development of machine-intelligence technology and its application to critical problems in defense

    SciTech Connect

    Conway, L.

    1984-01-01

    To meet the challenge of certain critical problems in defense, the Defense Advanced Research Projects Agency (DARPA) is initiating an important new program in strategic computing. By seizing an opportunity to leverage recent advances in artificial intelligence, computer science, and microelectronics, the agency plans to create a new generation of machine-intelligence technology.

  9. Strategic Defense Initiative, 1989. Report to the Congress

    SciTech Connect

    Not Available

    1989-03-13

    This report serves as a summary of the SDI legacy of President Reagan, who launched the initiative with his historic speech of March 23, 1983. The report describes in detail current assessment of the best program for resolution of remaining technical issues, validation of technologies, and demonstration of our ability to integrate them. The program of research, development, and testing would, if adequately funded, support a fully informed decision by the President and Congress in the future on whether to deploy a strategic defense of the United States. Such defenses could enhance deterrence and increase stability.

  10. Future SDI (Strategic Defense Initiative) decision making. Study project

    SciTech Connect

    Holman, B.W.

    1988-03-29

    Nearly five years have lapsed since President Reagan made his now famous speech launching his Strategic Defense Initiative. Yet, polarized debate continues over the program's feasibility, desirability, affordability, goals, and direction. Some claim the program's goals have changed over time, and that today the primary goal is for an enhanced deterrence rather than providing a population defense as originally envisioned. Although the Congress has provided continuing and expanded funding for SDI, a consensus does not exist between the Congress and the Administration over the program's direction and goals. Some concerns exist within the Congress that the Administration is rushing too quickly to reach a decision on initial system development. Others would like to see initial development of a more limited defensive capability than that envisioned by the SDI program. This paper examines the evolution of SDI from a policy standpoint and addresses a series of questions that taken together may suggest parameters for future decision making.

  11. Pennsylvania's Transition to Enterprise Computing as a Study in Strategic Alignment

    ERIC Educational Resources Information Center

    Sawyer, Steve; Hinnant, Charles C.; Rizzuto, Tracey

    2008-01-01

    We theorize about the strategic alignment of computing with organizational mission, using the Commonwealth of Pennsylvania's efforts to pursue digital government initiatives as evidence. To do this we draw on a decade (1995-2004) of changes in Pennsylvania to characterize how a state government shifts from an organizational to an enterprise…

  12. Pennsylvania's Transition to Enterprise Computing as a Study in Strategic Alignment

    ERIC Educational Resources Information Center

    Sawyer, Steve; Hinnant, Charles C.; Rizzuto, Tracey

    2008-01-01

    We theorize about the strategic alignment of computing with organizational mission, using the Commonwealth of Pennsylvania's efforts to pursue digital government initiatives as evidence. To do this we draw on a decade (1995-2004) of changes in Pennsylvania to characterize how a state government shifts from an organizational to an enterprise…

  13. 75 FR 60465 - Division of Program Coordination, Planning, and Strategic Initiatives, Office of the Director...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Division of Program Coordination, Planning, and Strategic... Secretary, Division of Program Coordination, Planning, and Strategic Initiatives, Office of the Director...

  14. Cloud computing strategic framework (FY13 - FY15).

    SciTech Connect

    Arellano, Lawrence R.; Arroyo, Steven C.; Giese, Gerald J.; Cox, Philip M.; Rogers, G. Kelly

    2012-11-01

    This document presents an architectural framework (plan) and roadmap for the implementation of a robust Cloud Computing capability at Sandia National Laboratories. It is intended to be a living document and serve as the basis for detailed implementation plans, project proposals and strategic investment requests.

  15. Combining Cases and Computer Simulations in Strategic Management Courses

    ERIC Educational Resources Information Center

    Mitchell, Rex C.

    2004-01-01

    In this study, the author compared the effectiveness of two different strategic management course designs: one centered on case discussions and the other combining a computer-based simulation with some cases. In addition to evaluation of the research literature, the study involved experiments with six course sections composed of 130 students, Both…

  16. Applications of the Strategic Defense Initiative's compact accelerators

    NASA Technical Reports Server (NTRS)

    Montanarelli, Nick; Lynch, Ted

    1991-01-01

    The Strategic Defense Initiative's (SDI) investment in particle accelerator technology for its directed energy weapons program has produced breakthroughs in the size and power of new accelerators. These accelerators, in turn, have produced spinoffs in several areas: the radio frequency quadrupole linear accelerator (RFQ linac) was recently incorporated into the design of a cancer therapy unit at the Loma Linda University Medical Center, an SDI-sponsored compact induction linear accelerator may replace Cobalt-60 radiation and hazardous ethylene-oxide as a method for sterilizing medical products, and other SDIO-funded accelerators may be used to produce the radioactive isotopes oxygen-15, nitrogen-13, carbon-11, and fluorine-18 for positron emission tomography (PET). Other applications of these accelerators include bomb detection, non-destructive inspection, decomposing toxic substances in contaminated ground water, and eliminating nuclear waste.

  17. SDI (Strategic Defense Initiative) software technology program plan. Final report

    SciTech Connect

    Linn, C.J.; Redwine, S.T.; Bloom, M.I.; Brykczynski, B.; Chludzinski, J.

    1987-06-01

    This paper was prepared in response to a request from the Battle Management C3 office within the Strategic Defense Initiative Organization (SDIO) of the Department of Defense (DoD). The request was for a software-technology program plan to define software research and development (RandD) efforts required by the SDI, and to provide the basis for integrating the SDIO software technology program with ongoing non-SDIO programs. The paper emphasizes reviewing the ongoing software programs and plans within the DoD and academia. The reviews identify critical software technology areas required to meet the unique SDI requirements, and indicate priorities among the software technologies to meet attainability, productivity, and reliability goals, as well as functional performance objectives.

  18. Looking beyond the Strategic Defense Initiative. Study project

    SciTech Connect

    Nichols, D.H.

    1988-03-30

    On 23 March 1983, President Reagan announced a new proposal. This study looks at the Strategic Defense Initiative (SDI) and how it will achieve the objectives President Reagan envisioned in his speech. It examines a scenario in which deterrence has failed and the time for Presidential decision making is severely compressed. It then looks at Presidential decision making during such a crisis and examines his options. Next, it looks at how the SDI is envisioned to work and contribute to the ultimate goal of eliminating the threat posed by nuclear ballistic missiles. Last, it examines the possibility that SDI may create a world we do not want; a dangerous world in which conventional wars between the two superpowers would become possible, maybe even probable. It does this by examining its impact on NATO, particularly in light of the proposed Intermediate-Range Nuclear Forces treaty.

  19. Applications of the Strategic Defense Initiative's compact accelerators

    NASA Astrophysics Data System (ADS)

    Montanarelli, Nick; Lynch, Ted

    1991-12-01

    The Strategic Defense Initiative's (SDI) investment in particle accelerator technology for its directed energy weapons program has produced breakthroughs in the size and power of new accelerators. These accelerators, in turn, have produced spinoffs in several areas: the radio frequency quadrupole linear accelerator (RFQ linac) was recently incorporated into the design of a cancer therapy unit at the Loma Linda University Medical Center, an SDI-sponsored compact induction linear accelerator may replace Cobalt-60 radiation and hazardous ethylene-oxide as a method for sterilizing medical products, and other SDIO-funded accelerators may be used to produce the radioactive isotopes oxygen-15, nitrogen-13, carbon-11, and fluorine-18 for positron emission tomography (PET). Other applications of these accelerators include bomb detection, non-destructive inspection, decomposing toxic substances in contaminated ground water, and eliminating nuclear waste.

  20. The Development of a Strategic Prioritisation Method for Green Supply Chain Initiatives

    PubMed Central

    Masoumik, S. Maryam; Abdul-Rashid, Salwa Hanim; Olugu, Ezutah Udoncy

    2015-01-01

    To maintain a competitive position, companies are increasingly required to integrate their proactive environmental strategies into their business strategies. The shift from reactive and compliance-based to proactive and strategic environmental management has driven companies to consider the strategic factors while identifying the areas in which they should focus their green initiatives. In previous studies little attention was given to providing the managers with a basis from which they could strategically prioritise these green initiatives across their companies’ supply chains. Considering this lacuna in the literature, we present a decision-making method for prioritising green supply chain initiatives aligned with the preferred green strategies alternatives for the manufacturing companies. To develop this method, the study considered a position between determinism and the voluntarism orientation of environmental management involving both external pressures and internal competitive drivers and key resources as decision factors. This decision-making method was developed using the analytic network process (ANP) technique. The elements of the decision model were derived from the literature. The causal relationships among the multiple decision variables were validated based on the results of structural equation modelling (SEM) using a dataset collected from a survey of the ISO 14001-certified manufacturers in Malaysia. A portion of the relative weights required for computation in ANP was also calculated using the SEM results. A case study is presented to demonstrate the applicability of the method. PMID:26618353

  1. The Development of a Strategic Prioritisation Method for Green Supply Chain Initiatives.

    PubMed

    Masoumik, S Maryam; Abdul-Rashid, Salwa Hanim; Olugu, Ezutah Udoncy

    2015-01-01

    To maintain a competitive position, companies are increasingly required to integrate their proactive environmental strategies into their business strategies. The shift from reactive and compliance-based to proactive and strategic environmental management has driven companies to consider the strategic factors while identifying the areas in which they should focus their green initiatives. In previous studies little attention was given to providing the managers with a basis from which they could strategically prioritise these green initiatives across their companies' supply chains. Considering this lacuna in the literature, we present a decision-making method for prioritising green supply chain initiatives aligned with the preferred green strategies alternatives for the manufacturing companies. To develop this method, the study considered a position between determinism and the voluntarism orientation of environmental management involving both external pressures and internal competitive drivers and key resources as decision factors. This decision-making method was developed using the analytic network process (ANP) technique. The elements of the decision model were derived from the literature. The causal relationships among the multiple decision variables were validated based on the results of structural equation modelling (SEM) using a dataset collected from a survey of the ISO 14001-certified manufacturers in Malaysia. A portion of the relative weights required for computation in ANP was also calculated using the SEM results. A case study is presented to demonstrate the applicability of the method.

  2. 75 FR 67149 - Request for Public Comment on the Draft 2010 National Nanotechnology Initiative Strategic Plan

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-01

    ... TECHNOLOGY POLICY Request for Public Comment on the Draft 2010 National Nanotechnology Initiative Strategic... request comments from the public regarding the draft 2010 National Nanotechnology Initiative (NNI... Nanotechnology Initiative (NNI) Strategic Plan is the framework that underpins the nanotechnology work of the NNI...

  3. The Strategic Retention Initiative: Theory-Based Practice to Reduce College Student Departure

    ERIC Educational Resources Information Center

    Brier, Ellen M.; Hirschy, Amy S.; Braxton, John M.

    2008-01-01

    The Strategic Retention Initiative is an administrative practice which involves calling all first-year students. The initiative is guided by an institutional commitment to the well-being of students and represents an institutional investment in student persistence. The development and implementation of the Strategic Retention Initiative was…

  4. Micro Computer Feedback Report for the Strategic Leader Development Inventory

    DTIC Science & Technology

    1994-07-01

    AD-A283 540 Research Product 94-13 Micro Computer Feedback Report for the Strategic Leader Development Inventory -DT IC L E- T E9 July 1994 Strategic...public release; distribution is unlimited. 9 4 -2 6 6 0 0 94 8 19 1 20 .. .. . .•. . ,, mi i I IIII I Best Available Copy U.S. ARMY RESEARCH INSTITUTE...position, unless so designated by other authorized documents. REPORT DOCUMENTATION PAGE J o-m ApprovedI .’f3 NVo. 0704-018,3 Puoih ’ Oc r to l g ur1c

  5. Origins of the Strategic Defense Initiative: Ballistic Missile Defense, 1944-1983. Final report

    SciTech Connect

    Baucom, D.R.

    1989-12-01

    America's ballistic missile defense program may be said to have its roots in the V-2 attacks on London in 1944. This document traces the development of antiballistic missile defense policy from the V-2 attacks up to President Reagan's 1983 speech announcing the new strategic defense initiative. The history follows the policy debates from the NIKE-X, SALT I and SALT II, the ABM Treaty, and SAFEGUARD through research and development innovations in the areas of computers, optical sensors, interceptors, and directed energy weapons. The emergence of political organizations and individuals who either opposed or championed ballistic missile defense is also included.

  6. Driver-initiated distractions: examining strategic adaptation for in-vehicle task initiation.

    PubMed

    Horrey, William J; Lesch, Mary F

    2009-01-01

    Today, drivers are faced with many in-vehicle activities that are potentially distracting. In many cases, they are not passive recipients of these tasks; rather, drivers decide whether or not (or how) to perform them. In this study, we examined whether drivers, given knowledge of the upcoming road demands, would strategically delay performing in-vehicle activities until demands were reduced. Twenty drivers drove an instrumented van around a closed track that was divided into sections of varying demands and difficulty. Drivers were asked to perform one of four in-vehicle tasks (e.g., phone conversation; read a text message; find an address; pick up an object on the floor); however, they were free to decide when to initiate these tasks, provided they finish them before a given deadline. Although drivers were fully aware of the relative demands of the road, they did not tend to strategically postpone tasks--a finding that was consistent across the different tasks (p >.05). Rather, drivers tended to initiate tasks regardless of the current driving conditions. This strategy frequently led to driving errors. Given the control that drivers have over many in-vehicle distractions, interventions that focus on strategic decisions and planning may have merit.

  7. Crew and Thermal Systems Division Strategic Communications Initiatives in Support of NASA's Strategic Goals: Fiscal Year 2012 Summary and Initial Fiscal Year 2013 Metrics

    NASA Technical Reports Server (NTRS)

    Paul, Heather L.

    2013-01-01

    The NASA strategic plan includes overarching strategies to inspire students through interactions with NASA people and projects, and to expand partnerships with industry and academia around the world. The NASA Johnson Space Center Crew and Thermal Systems Division (CTSD) actively supports these NASA initiatives. At the end of fiscal year 2011, CTSD created a strategic communications team to communicate CTSD capabilities, technologies, and personnel to internal NASA and external technical audiences for collaborative and business development initiatives, and to students, educators, and the general public for education and public outreach efforts. The strategic communications initiatives implemented in fiscal year 2012 resulted in 707 in-reach, outreach, and commercialization events with 39,731 participant interactions. This paper summarizes the CTSD Strategic Communications metrics for fiscal year 2012 and provides metrics for the first nine months of fiscal year 2013.

  8. Descriptive Case Study of Theories of Action, Strategic Objectives, and Strategic Initiatives Used by California Female County Superintendents to Move Their Organizations from Current State to Desired Future

    ERIC Educational Resources Information Center

    Park, Valerie Darlene

    2014-01-01

    The purpose of this study was to describe the theories of action, strategic objectives, and strategic initiatives of school systems led by female county superintendents in California and examine their impact on improving system outcomes. Additionally, the factors influencing theory of action, strategic objective, and initiative development were…

  9. Descriptive Case Study of Theories of Action, Strategic Objectives, and Strategic Initiatives Used by California Female County Superintendents to Move Their Organizations from Current State to Desired Future

    ERIC Educational Resources Information Center

    Park, Valerie Darlene

    2014-01-01

    The purpose of this study was to describe the theories of action, strategic objectives, and strategic initiatives of school systems led by female county superintendents in California and examine their impact on improving system outcomes. Additionally, the factors influencing theory of action, strategic objective, and initiative development were…

  10. Soviet military on SDI (Strategic Defense Initiative). Professional paper

    SciTech Connect

    Fitzgerald, M.C.

    1987-08-01

    Numerous Western analysts have suggested that all American assessments of SDI should proceed not only from a consideration of American intentions, but also from the outlook of Soviet perceptions. Since 23 March 1983, the prevailing tone of Soviet military writings on SDI has been overwhelmingly negative. Myron Hedlin has concluded that this harsh reaction to a U.S. initiative still years from realization suggests both a strong concern about the ultimate impact of these plans on the strategic balance, and a perceived opportunity for scoring propaganda points. Indeed, the present review of Soviet writings since President Reagan's so-called Star Wars speech has yielded both objective Soviet concerns and regressions to psychological warfare. This, in turn, has necessitated a careful effort to separate rhetoric from more official assessments of SDI. While there has long been dispute in the West over the validity of Soviet statements, they have time and again been subsequently confirmed in Soviet hardware, exercises, and operational behavior. Some Western analysts will nonetheless contend that the Soviet statements under examination in this study are merely a commodity for export.

  11. Strategically Funny: Romantic Motives Affect Humor Style in Relationship Initiation.

    PubMed

    DiDonato, Theresa E; Jakubiak, Brittany K

    2016-08-01

    Not all humor is the same, yet little is known about the appeal of specific humor styles in romantic initiation. The current experimental study addresses this gap by investigating how romantic motives (short-term or long-term) affect individuals' anticipated use of, and response to, positive humor and negative humor. Heterosexual participants (n = 224) imagined the pursuit of either a desired short-term or long-term relationship, indicated the extent to which they would produce positive and negative humor, and reported how their own interest would change in response to the imaginary target's use of positive or negative humor. Results revealed that individuals are strategic in their humor production as a function of relational motives. Individuals produced positive humor in both contexts but limited their use of negative humor when pursuing a long-term relationship. The target's positive humor increased individuals' attraction, especially women's, and although negative humor boosted attraction, it did not boost attraction more for short-term than long-term relationships. Findings extend a trait-indicator model of humor and their implications are discussed in light of other theoretical perspectives.

  12. Strategically Funny: Romantic Motives Affect Humor Style in Relationship Initiation

    PubMed Central

    DiDonato, Theresa E.; Jakubiak, Brittany K.

    2016-01-01

    Not all humor is the same, yet little is known about the appeal of specific humor styles in romantic initiation. The current experimental study addresses this gap by investigating how romantic motives (short-term or long-term) affect individuals’ anticipated use of, and response to, positive humor and negative humor. Heterosexual participants (n = 224) imagined the pursuit of either a desired short-term or long-term relationship, indicated the extent to which they would produce positive and negative humor, and reported how their own interest would change in response to the imaginary target’s use of positive or negative humor. Results revealed that individuals are strategic in their humor production as a function of relational motives. Individuals produced positive humor in both contexts but limited their use of negative humor when pursuing a long-term relationship. The target’s positive humor increased individuals’ attraction, especially women’s, and although negative humor boosted attraction, it did not boost attraction more for short-term than long-term relationships. Findings extend a trait-indicator model of humor and their implications are discussed in light of other theoretical perspectives. PMID:27547256

  13. The strategic offense initiative? The Soviets and Star Wars

    SciTech Connect

    Westwick, Peter J.

    2014-05-09

    Historians of the Cold War have paid too little attention to Soviet fears of 'space-strike weapons' - that is, possible offensive uses of President Ronald Reagan's Strategic Defense Initiative. In fifteen years or so, soldiers will no longer shoot rifles but will use some kind of lightning, some sort of a machine emitting a holocaustal electrical beam. Tell me, what can we invent in this line so as to surprise our neighbors?... Alas, we are only capable of imitating and purchasing weapons from others, and we do well if we manage to repair them ourselves. --Fyodor Dostoevsky, A Writer's Diary, 1873. [Khlinov, a physicist]: 'I know that he has made an important discovery concerning the transmission of infra-red rays over a distance.... Heat waves at a temperature of a thousand degrees centigrade transmitted parallel to each other constitute a monstrous weapon of destruction and defense in time of war. The whole secret lies in the transmission of a ray that does not disperse. So far nobody has been able to do this. Judging by your story, Garin has constructed a machine that will do it. If so it is an extremely important discovery.' 'I've been thinking for a long time that this invention smells of higher politics,' said Shelga. --Aleksei Tolstoy, The Garin Death Ray, 1927 (translated by George Hanna)

  14. The strategic offense initiative? The Soviets and Star Wars

    NASA Astrophysics Data System (ADS)

    Westwick, Peter J.

    2014-05-01

    Historians of the Cold War have paid too little attention to Soviet fears of "space-strike weapons" - that is, possible offensive uses of President Ronald Reagan's Strategic Defense Initiative. In fifteen years or so, soldiers will no longer shoot rifles but will use some kind of lightning, some sort of a machine emitting a holocaustal electrical beam. Tell me, what can we invent in this line so as to surprise our neighbors?... Alas, we are only capable of imitating and purchasing weapons from others, and we do well if we manage to repair them ourselves. --Fyodor Dostoevsky, A Writer's Diary, 1873. [Khlinov, a physicist]: "I know that he has made an important discovery concerning the transmission of infra-red rays over a distance.... Heat waves at a temperature of a thousand degrees centigrade transmitted parallel to each other constitute a monstrous weapon of destruction and defense in time of war. The whole secret lies in the transmission of a ray that does not disperse. So far nobody has been able to do this. Judging by your story, Garin has constructed a machine that will do it. If so it is an extremely important discovery." "I've been thinking for a long time that this invention smells of higher politics," said Shelga. --Aleksei Tolstoy, The Garin Death Ray, 1927 (translated by George Hanna)

  15. Strategic Implications of Cloud Computing for Modeling and Simulation (Briefing)

    DTIC Science & Technology

    2016-04-01

    Service: Pay per use / new business models • Exercise Specific: – Set up costs – Ramping up time Plot four routes from my current location to my new...Strategic Implications of Cloud Computing for Modeling and Simulation (Briefing) Amy E. Henninger I N S T I T U T E F O R D E F E N S E A N A L... Implications of Cloud Computing for Modeling and Simulation NDIA SE Division M&S Committee April 19, 2016 NOTES: • This brief was designed for

  16. Strategic defense initiative impacts on manned Mars missions

    NASA Technical Reports Server (NTRS)

    Nozette, S.

    1986-01-01

    Research conducted on a strategic defense system with space based elements may provide key components of systems necessary for Manned Mars Missions. Three areas of impact are space logistics, space power, and supporting systems. These areas are discussed briefly.

  17. Strategic Defense Initiative. Issues and implications for the Atlantic Alliance. Final report

    SciTech Connect

    Davidson, C.G.

    1988-05-01

    An analysis of the arguments exchanged between the US and Western European nations since the announcement of the Strategic Defense Initiative (SDI) program, showing that the importance of the SDI for Europe lies in the discussion of European security it has brought forth as opposed to the undefined strategic concept behind it or in the nature of the research to attain it.

  18. Strategic Defense Initiative: implications for US deterrence policy

    SciTech Connect

    MacDougall, A.S.

    1987-01-01

    While ballistic missile defenses (formerly called ABMs) were believed foreclosed from the nuclear balance as a result of the ABM Treaty, the SDI program has brought ballistic missile defenses back into the strategic equation. It is possible to suggest that missile defenses may make a significant contribution to US national security. Given this proposition, the dissertation follows the analysis as outlined: (1) The original ABM debate of the late 1960s is reviewed with respect to the arguments of proponents and opponents of the ABM. This debate led the US to accept the dominance of offensive nuclear forces in the nuclear balance. (2) While the US had foresworn working on ballistic-missile defenses during the 1970s, the strategic nuclear balance and foundations of deterrence have changed. (3) US strategic nuclear policy has evolved since the late 1960s to incorporate three major policy schools: assured destruction, countervailing, and nuclear war-fighting. Ballistic missile defenses fit with these policies in quite different ways. (4) US strategic offensive nuclear forces may be altered significantly by the deployment of a missile defense. (5) A US missile defense could effectively break up the ABM Treaty and spell an end to the arms control process. On the other hand, the SDI also may serve as an impetus to a new arms control treaty which incorporates reductions in offensive nuclear forces.

  19. A Preliminary Analysis of a Strategic Staffing Initiative

    ERIC Educational Resources Information Center

    Pulliam, Cheryl L.; LaCaria, Lynne; Schoeneberger, Jason; Algozzine, Bob

    2014-01-01

    The authors evaluated a reform program known as "Strategic Staffing" in which principals were given increased autonomy to modify the delivery of instruction without compromising academic content. The program's central feature was reassignment of school leaders and key staff members from settings in which they were successful to schools…

  20. From ''Star Wars'' to strategic defensive initiative. European perceptions and assessments

    SciTech Connect

    Brauch, H.G.

    1986-01-01

    This book examines the Strategic Defense Initiative (SDI) debate. The implications of SDI for the Wests' nuclear strategy are assessed and the implications of SDI for treaties and for arms control are discussed.

  1. Outplayed: Regaining Strategic Initiative in the Gray Zone

    DTIC Science & Technology

    2016-06-01

    economics will affect business out- comes. However, those responsible for gauging financial risk for corporations , share- holders, and customers do...national security, resource management, and responsible command. The U.S. Army Heritage and Education Center acquires, conserves, and exhibits...and quick-reaction responses to senior Army leaders. The Institute provides a valuable analytical capability within the Army to address strategic and

  2. Interim Strategic Defense Initiative arms negotiation strategy. Research report

    SciTech Connect

    Marshall, H.A.

    1986-05-01

    Comments are presented on some of the pros and cons of the Strategic Defense Initative (SDI). Key issues discussed relate to the projected cost of SDI and the potential violation of the 1972 Anti-ballistic Missile Treaty. A solution is proposed that has the potential to significantly reduce the total cost and circumvents the treaty resulting in the deployment of a more-effective ballistic missile defense system.

  3. An Evaluation of Potential Countermeasures to the Strategic Defense Initiative.

    DTIC Science & Technology

    1986-03-01

    intensive effort to define a long term research and development program to achieve our ultimate goal of eliminating the threat posed by strategic...conventional weapons, the deploy- ment of a BMD would greatly increase the risk of conventional war. (5) that the long transition period from a U.S...March 109 16 SLPPLEMENTARY NOTATION 7 COSATI CODES 18 SUBJC.T TERMS (Continue on reverse if necessary and identify by block number) rELD GROUP SUB

  4. Framework for understanding the Strategic Defense Initiatives' software debates. Master's thesis

    SciTech Connect

    Adams, R.C.

    1990-06-01

    On March 23, 1983, then-President Ronald Reagan challenged a group of engineers and scientists to make nuclear weapons impotent and obsolete. This challenge led to the beginning of a new era in space technology and strategic defense, thus creating the Strategic Defense Initiative (SDI), better known as Star Wars. By 1984, several studies had begun to show that software in conjunction with Battle Management/Command, Control, and Communications techniques would play a major role in determining the effectiveness of the SDI. The results from these studies caused numerous controversial debates on the reliability, dependability, and trustworthiness of the software. This thesis provides a framework for understanding the complexities of the SDI software and points out some of the major issues involved in the software debates. The structure for this thesis is based on presenting the opinions of various computer scientists and engineers, indicating the issues that are controversial and those that have been defined as a necessity for the SDI program. One of the major highlights is the SDI summary chart that provides the reader with a very brief narrative of each individuals' opinion on the software issues discussed in this thesis.

  5. Mobile computing initiatives within pharmacy education.

    PubMed

    Cain, Jeff; Bird, Eleanora R; Jones, Mikael

    2008-08-15

    To identify mobile computing initiatives within pharmacy education, including how devices are obtained, supported, and utilized within the curriculum. An 18-item questionnaire was developed and delivered to academic affairs deans (or closest equivalent) of 98 colleges and schools of pharmacy. Fifty-four colleges and schools completed the questionnaire for a 55% completion rate. Thirteen of those schools have implemented mobile computing requirements for students. Twenty schools reported they were likely to formally consider implementing a mobile computing initiative within 5 years. Numerous models of mobile computing initiatives exist in terms of device obtainment, technical support, infrastructure, and utilization within the curriculum. Responders identified flexibility in teaching and learning as the most positive aspect of the initiatives and computer-aided distraction as the most negative, Numerous factors should be taken into consideration when deciding if and how a mobile computing requirement should be implemented.

  6. Strategic Cognitive Sequencing: A Computational Cognitive Neuroscience Approach

    PubMed Central

    Herd, Seth A.; Krueger, Kai A.; Kriete, Trenton E.; Huang, Tsung-Ren; Hazy, Thomas E.; O'Reilly, Randall C.

    2013-01-01

    We address strategic cognitive sequencing, the “outer loop” of human cognition: how the brain decides what cognitive process to apply at a given moment to solve complex, multistep cognitive tasks. We argue that this topic has been neglected relative to its importance for systematic reasons but that recent work on how individual brain systems accomplish their computations has set the stage for productively addressing how brain regions coordinate over time to accomplish our most impressive thinking. We present four preliminary neural network models. The first addresses how the prefrontal cortex (PFC) and basal ganglia (BG) cooperate to perform trial-and-error learning of short sequences; the next, how several areas of PFC learn to make predictions of likely reward, and how this contributes to the BG making decisions at the level of strategies. The third models address how PFC, BG, parietal cortex, and hippocampus can work together to memorize sequences of cognitive actions from instruction (or “self-instruction”). The last shows how a constraint satisfaction process can find useful plans. The PFC maintains current and goal states and associates from both of these to find a “bridging” state, an abstract plan. We discuss how these processes could work together to produce strategic cognitive sequencing and discuss future directions in this area. PMID:23935605

  7. Strategic cognitive sequencing: a computational cognitive neuroscience approach.

    PubMed

    Herd, Seth A; Krueger, Kai A; Kriete, Trenton E; Huang, Tsung-Ren; Hazy, Thomas E; O'Reilly, Randall C

    2013-01-01

    We address strategic cognitive sequencing, the "outer loop" of human cognition: how the brain decides what cognitive process to apply at a given moment to solve complex, multistep cognitive tasks. We argue that this topic has been neglected relative to its importance for systematic reasons but that recent work on how individual brain systems accomplish their computations has set the stage for productively addressing how brain regions coordinate over time to accomplish our most impressive thinking. We present four preliminary neural network models. The first addresses how the prefrontal cortex (PFC) and basal ganglia (BG) cooperate to perform trial-and-error learning of short sequences; the next, how several areas of PFC learn to make predictions of likely reward, and how this contributes to the BG making decisions at the level of strategies. The third models address how PFC, BG, parietal cortex, and hippocampus can work together to memorize sequences of cognitive actions from instruction (or "self-instruction"). The last shows how a constraint satisfaction process can find useful plans. The PFC maintains current and goal states and associates from both of these to find a "bridging" state, an abstract plan. We discuss how these processes could work together to produce strategic cognitive sequencing and discuss future directions in this area.

  8. Level-2 Milestone 5588: Deliver Strategic Plan and Initial Scalability Assessment by Advanced Architecture and Portability Specialists Team

    SciTech Connect

    Draeger, Erik W.

    2016-09-30

    This report documents the fact that the work in creating a strategic plan and beginning customer engagements has been completed. The description of milestone is: The newly formed advanced architecture and portability specialists (AAPS) team will develop a strategic plan to meet the goals of 1) sharing knowledge and experience with code teams to ensure that ASC codes run well on new architectures, and 2) supplying skilled computational scientists to put the strategy into practice. The plan will be delivered to ASC management in the first quarter. By the fourth quarter, the team will identify their first customers within PEM and IC, perform an initial assessment and scalability and performance bottleneck for next-generation architectures, and embed AAPS team members with customer code teams to assist with initial portability development within standalone kernels or proxy applications.

  9. Origins of the Strategic Defense Initiative: Ballistic Missile Defense, 1944-1983

    DTIC Science & Technology

    1989-12-01

    Weapons, DEWs KEWs , Kinetic Energy Weppons, Policy ORIGINS OF THE STRATEGIC DEFENSE INITIATIVE: BALLISTIC MISSILE DEFENSE, 19 44 - 19 8 3 CLEAREDI...Furthermore, as previously noted, he hoped to improve the 1Doubletalk: The Story of the First Strategic Arms ALimitations Talks ( Garden City, N.Y...ASM System Stuns the Town of Langdon, N.D.," Kew York Times, 25 November 1975, p. 74; Bill Richards, "Town Fears Chaos If ABM Site Shut," Washington

  10. Strategic Defense Initiative: Splendid Defense or Pipe Dream? Headline Series No. 275.

    ERIC Educational Resources Information Center

    Armstrong, Scott; Grier, Peter

    This pamphlet presents a discussion of the various components of President Reagan's Strategic Defense Initiative (SDI) including the problem of pulling together various new technologies into an effective defensive system and the politics of the so-called "star wars" system. An important part of the defense initiative is the…

  11. Strategic Defense Initiative: Splendid Defense or Pipe Dream? Headline Series No. 275.

    ERIC Educational Resources Information Center

    Armstrong, Scott; Grier, Peter

    This pamphlet presents a discussion of the various components of President Reagan's Strategic Defense Initiative (SDI) including the problem of pulling together various new technologies into an effective defensive system and the politics of the so-called "star wars" system. An important part of the defense initiative is the…

  12. Notification: Audit of EPA's Cloud Computer Initiative

    EPA Pesticide Factsheets

    Project #OA-FY13-0095, December 17, 2012. The U.S. Environmental Protection Agency (EPA) Office of Inspector General plans to begin preliminary research on the audit of EPA’s cloud computer initiative.

  13. Report to the Congress on the Strategic Defense Initiative 1990

    DTIC Science & Technology

    1990-05-01

    7-10 7.2.4 Network Concepts ..................................................................... 7-113 7.2.5 C om m unications ...Computer routing Dynamic reprogramming of paths through arrays of computers for high-efficiency optimization processing Holographic missile tag One-of-a

  14. Preserving the ABM treaty: a critique of the Reagan Strategic Defense Initiative

    SciTech Connect

    Drell, Sidney D.; Farley, Philip J.; Holloway, David

    1994-10-01

    President Reagan's Strategic Defense Initiative (SDI) proposal for long-term research and development on a leak-proof defense capability conflicts with the past 15 years of Soviet-American strategic relations and arms control negotiations. It represents a unilateral change, and will elicit a Soviet response based on how the Soviets think their own security may be affected. Whether the SDI transcends or enhances defense, it raises basic issues involving the US-Soviet strategic relationship. Emphasizing the central bearing of the Anti-Ballistic Missile (ABM) Treaty of 1972 the author reviews these issues and questions about the technical and strategic grounds of the proposal. Three recommendations are to limit the SDI program to a search for scientific possibilities, to consult with the Soviets on the ABM Treaty, and to recognize that the ABM Treaty will enhance security more than the SDI. 58 references.

  15. Possible Soviet response to the Strategic Defense Initiative: a functionally organized taxonomy. Interim report

    SciTech Connect

    Lewis, K.N.

    1986-07-01

    In the wake of the Strategic Defense Initiative (SDI), much effort has been devoted to estimating potential Soviet responses to it. There is general agreement that the Soviet response will (1) consist of attempts to stop, circumvent, emulate, and neutralize the SDI; (2) include political, military, and strategic efforts; and (3) vary over time, depending on several factors. Setting aside Soviet technological options, this note considers various factors that might interest or influence senior Soviet decision makers as they consider a range of programmatic, strategic, and political options for responding to the SDI. Its goal is to identify generic categories of Soviet response options rather than the specific forms those options may take. Contents include: Precursors to any Taxonomy of Soviet Responses to SDI; Primarily Military or Technological Steps; Primarily Grand Strategic Steps; and Primarily Political Steps.

  16. Strategic development of medicines information: Expanding key global initiatives.

    PubMed

    Hämeen-Anttila, Katri

    2016-01-01

    Medicines information (MI) is a broad concept that includes information targeted to health care professionals as well as to patients. It may be in written, electronic or verbal forms. The internet is becoming more widely used as a source for MI, even though research shows that health care professionals and patient information leaflets are still the most common sources for medicine users. As patients are increasingly looking for the information they need themselves, the role of health care professionals in providing information is evolving, and there exists a need for greater health literacy skills among the patients. Medicines information as a concept is often defined and understood differently. Furthermore, it is such an integral part of pharmacy practice that it is rarely discussed as a separate entity. However, there is a growing recognition of a need to discuss MI in a broader sense and consider national strategies to meet consumer needs for medicines information. It also has been recognized that provision of MI should be a shared responsibility of all stakeholders in health care. This commentary gives an example of national level strategic development of MI, and calls for international collaboration. Copyright © 2016 Elsevier Inc. All rights reserved.

  17. Mexico City Air Quality Research Initiative; Volume 5, Strategic evaluation

    SciTech Connect

    1994-03-01

    Members of the Task HI (Strategic Evaluation) team were responsible for the development of a methodology to evaluate policies designed to alleviate air pollution in Mexico City. This methodology utilizes information from various reports that examined ways to reduce pollutant emissions, results from models that calculate the improvement in air quality due to a reduction in pollutant emissions, and the opinions of experts as to the requirements and trade-offs that are involved in developing a program to address the air pollution problem in Mexico City. The methodology combines these data to produce comparisons between different approaches to improving Mexico City`s air quality. These comparisons take into account not only objective factors such as the air quality improvement or cost of the different approaches, but also subjective factors such as public acceptance or political attractiveness of the different approaches. The end result of the process is a ranking of the different approaches and, more importantly, the process provides insights into the implications of implementing a particular approach or policy.

  18. Report to the Congress on the Strategic Defense Initiative, 1989

    DTIC Science & Technology

    1989-03-13

    scale packaging to a signal and data processor that can fit in the palm of a hand and has the equivalent capacity of a Cray computer. American...Odetr 0 FIed Caiborbon ?nutem 2 fStage Stage lit hrdnerpeatina cmpnets Key ~2n GB voi Stagpoent arlh aapoesso an lU.pmrimr Stage Not shown to acaie

  19. The Why, What, and How of the Strategic Defense Initiative.

    DTIC Science & Technology

    1985-03-01

    new technologies and provide confidence that full scale development can be initiated. SPACE SURVEILLANCE AIRBORNE OPTICAL SENSOR TERMINAL RADAR...phase and post-boost ve - hicle intercept. Directed energy weapons such as lasers and particle beams have the promise to provide for long-range

  20. Strategic Flexibility in Computational Estimation for Chinese- and Canadian-Educated Adults

    ERIC Educational Resources Information Center

    Xu, Chang; Wells, Emma; LeFevre, Jo-Anne; Imbo, Ineke

    2014-01-01

    The purpose of the present study was to examine factors that influence strategic flexibility in computational estimation for Chinese- and Canadian-educated adults. Strategic flexibility was operationalized as the percentage of trials on which participants chose the problem-based procedure that best balanced proximity to the correct answer with…

  1. The Strategic Defense Initiative and West European Security.

    DTIC Science & Technology

    1986-04-14

    INITIATIVE AND WESTERN SECURITY An analysis of the merits of the SDI is of great importance as the program could have a considerable impact on NATO’s...strategy of flexibility in response. Such an analysis must be based on a factual evaluation of the realities of the 1980s in which ballistic missile...American security remains coupled with that of NATO Europe. An analysis of the nature of the military threat and Soviet military doctrine suggests that

  2. Arms Control and the Strategic Defense Initiative: Three Perspectives. Occasional Paper 36.

    ERIC Educational Resources Information Center

    Hough, Jerry F.; And Others

    Three perspectives on President Ronald Reagan's Strategic Defense Initiative (SDI), which is intended to defend U.S. targets from a Soviet nuclear attack, are presented in separate sections. In the first section, "Soviet Interpretation and Response," Jerry F. Hough examines possible reasons for Soviet preoccupation with SDI. He discusses…

  3. Technology Transfer and Innovation Initiatives in Strategic Management: Generating an Alternative Perspective

    ERIC Educational Resources Information Center

    Major, E.

    2003-01-01

    This paper taps the strategic management discipline to inform our understanding of technology transfer and innovation (TTI) initiatives. With special focus on the UK Foresight programme it considers the impacts that the resource-based and core competence approaches to strategy can have on understanding the nature and effectiveness of TTI…

  4. Science, Space, and Scholarship: University Research and the Strategic Defense Initiative. ASHE 1987 Annual Meeting Paper.

    ERIC Educational Resources Information Center

    Knight, Randall D.

    Issues concerning the federal role in financing research and development (R&D) and the impact of these policies on academic research are examined. Specific concerns are whether the Reagan Administration is militarizing research and implications of the Strategic Defense Initiative (SDI) program. National Science Foundation data are examined,…

  5. Soviet Union and the Strategic Defense Initiative: preliminary findings and impressions. Interim report

    SciTech Connect

    Lambeth, B.S.

    1986-06-01

    This note provides a background against which to evaluate possible Soviet alternatives for dealing with the Strategic Defense Initiative (SDI) in the decade ahead. Without speculating about what the Soviets will ultimately do in response to SDI, the note (1) examines Moscow's statements on SDI to date, (2) reviews the highlights of Soviet doctrine and programs related to strategic defense, (3) considers the real concerns that may underline the Kremlin's public posturing on SDI, and (4) outlines the key political and strategic factors that will constrain the Soviets' eventual response. The author suggests that, assuming SDI does lead to a deployable U.S. ballistic missile defense, the Soviets will be driven to counter that threat within the limits of their economic and technical resources. Forecasting the technical details of their response at this time, however, is complicated by uncertainty not only about Soviet concerns, motivations, and intentions, but also about what the United States will eventually do with SDI.

  6. Threat and opportunity: the Soviet view of the Strategic Defense Initiative. Master's thesis

    SciTech Connect

    Uchrinscko, K.W.

    1986-12-01

    The Soviet response to the Strategic Defense Initiative (SDI) during the period March 1983 through November 1985 provided indications of their view of the program both as a threat and as an opportunity to weaken NATO. The SDI is seen not only as a threat to the physical security of the Soviet Union but as part of an effort by the United States to seize the strategic initiative by neutralizing the military component of Soviet strategy. A major objective of that strategy is the political separation of Western Europe from the United States, which the Soviets sought to facilitate by aggravating allied concern over the SDI's potential implications for European security and economic interests.

  7. Analysis of the Soviet response to the Strategic Defense Initiative (SDI). Student report

    SciTech Connect

    Morgan, D.E.

    1987-04-01

    Since President Reagan announced the Strategic Defense Initiative (SDI) in March 1983, the Soviet Union has consistently condemned it. This study examines the Soviet response to SDI and provides an explanation for their response. The study identifies military, political, and economic factors that influence the Soviet response to SDI. The author concludes that the Soviets have a genuine concern about SDI, and they will continue their attempts to stop the SDI program at the arms-control negotiations.

  8. Using a concept map as a tool for strategic planning: The Healthy Brain Initiative.

    PubMed

    Anderson, Lynda A; Day, Kristine L; Vandenberg, Anna E

    2011-09-01

    Concept mapping is a tool to assist in strategic planning that allows planners to work through a sequence of phases to produce a conceptual framework. Although several studies describe how concept mapping is applied to various public health problems, the flexibility of the methods used in each phase of the process is often overlooked. If practitioners were more aware of the flexibility, more public health endeavors could benefit from using concept mapping as a tool for strategic planning. The objective of this article is to describe how the 6 concept-mapping phases originally outlined by William Trochim guided our strategic planning process and how we adjusted the specific methods in the first 2 phases to meet the specialized needs and requirements to create The Healthy Brain Initiative: A National Public Health Road Map to Maintaining Cognitive Health. In the first stage (phases 1 and 2 of concept mapping), we formed a steering committee, convened 4 work groups over a period of 3 months, and generated an initial set of 42 action items grounded in science. In the second stage (phases 3 and 4), we engaged stakeholders in sorting and rating the action items and constructed a series of concept maps. In the third and final stage (phases 5 and 6), we examined and refined the action items and generated a final concept map consisting of 44 action items. We then selected the top 10 action items, and in 2007, we published The Healthy Brain Initiative: A National Public Health Road Map to Maintaining Cognitive Health, which represents the strategic plan for The Healthy Brain Initiative.

  9. SDIO (Strategic Defense Initiative Office) Technical Information Management Center Bibliography of unclassified books: January-December 1986

    SciTech Connect

    Not Available

    1986-12-01

    This bibliography lists the Strategic Defense Initiative Organization Technical Information Management Center's holdings of publications pertaining to such topics as ballistic missile defense, arms control impact statements, beam weapons, strategic decision making, aluminum-lithium alloys, laser weapons, military space policy, and radar electronic counter countermeasures.

  10. Health care administrators' perspectives on the role of absorptive capacity for strategic change initiatives: a qualitative study.

    PubMed

    Kash, Bita A; Spaulding, Aaron; Gamm, Larry; Johnson, Christopher E

    2013-01-01

    The dimensions of absorptive capacity (ACAP) are defined, and the importance of ACAP is established in the management literature, but the concept has not been applied to health care organizations attempting to implement multiple strategic initiatives. The aim of this study was to test the utility of ACAP by analyzing health care administrators' experiences with multiple strategic initiatives within two health systems. Results are drawn from administrators' assessments of multiple initiatives within two health systems using in-depth personal interviews with a total of 61 health care administrators. Data analysis was performed following deductive qualitative analysis guidelines. Interview transcripts were coded based on the four dimensions of ACAP: acquiring, assimilating, internalizing/transforming, and exploiting knowledge. Furthermore, we link results related to utilization of management resources, including number of key personnel involved and time consumption, to dimensions of ACAP. Participants' description of multiple strategic change initiatives confirmed the importance of the four ACAP dimensions. ACAP can be a useful framework to assess organizational capacity with respect to the organization's ability to concurrently implement multiple strategic initiatives. This capacity specifically revolves around human capital requirements from upper management based on the initiatives' location or stage within the ACAP framework. Strategic change initiatives in health care can be usefully viewed from an ACAP perspective. There is a tendency for those strategic initiatives ranking higher in priority and time consumption to reflect more advanced dimensions of ACAP (assimilate and transform), whereas few initiatives were identified in the ACAP "exploit" dimension. This may suggest that health care leaders tend to no longer identify as strategic initiatives those innovations that have moved to the exploitation stage or that less attention is given to the exploitation

  11. Collaborative Strategic Board Games as a Site for Distributed Computational Thinking

    ERIC Educational Resources Information Center

    Berland, Matthew; Lee, Victor R.

    2011-01-01

    This paper examines the idea that contemporary strategic board games represent an informal, interactional context in which complex computational thinking takes place. When games are collaborative--that is, a game requires that players work in joint pursuit of a shared goal--the computational thinking is easily observed as distributed across…

  12. SDI (Strategic Defense Initiative): where do we go from here. Study project

    SciTech Connect

    Dierker, R.R.

    1988-03-30

    President Reagan's announcement five years ago of his vision for a Strategic Defense Initiative (SDI) has had strong implications for the United States nuclear strategy. Implementation of any or all parts of a strategic defense system would constitute a shift away from the offense-dominant strategy that the U.S. has espoused for over forty years. Effecting a shift in U.S. nuclear strategy while maintaining stability between the superpowers is an extremely difficult task. Opponents of SDI have raised the question of whether we should pursue SDI and the ensuing shift in strategy at all. The only real question to be answered is how to effect a stable shift in U.S. strategy. The key to that shift is understanding and then considering the Soviets' views of SDI. The author discusses Soviet views of the U.S.'s Strategic Defense Initiative and then examines four possible U.S. options for SDI, ranging from unilateral deployment to use as a bargaining chip.

  13. A Strategic Initiative in Applied Biological Simulations 01-SI-012 Final Report for FY01 - FY03

    SciTech Connect

    Lau, E Y; Venclovas, C; Schwegler, E; Gygi, F; Colvin, M E; Bennion, B J; Barsky, D; Mundy, C; Lightstone, F C; Galli, G; Sawicka, D

    2004-02-16

    The goal of this Strategic Initiative in Applied Computational Biology has been to apply LLNL's expertise in computational simulation to forge a new laboratory core competency in biological simulation. By every measure, this SI has been very successful in this goal. Based on a strong publication record and large number of conference presentations and invited talks, we have built a recognized niche for LLNL in the burgeoning field of computational biology. Further, many of the projects that were previously part of this LDRD are now externally funded based on the research results and expertise developed under this SI. We have created successful collaborations with a number of outside research groups including several joint projects with the new UC Davis/LLNL Comprehensive Cancer Center. In addition to these scientific collaborations, the staff developed on this SI is involved in computational biology program development and advisory roles with other DOE laboratories and DOE Headquarters. Moreover, a number of capabilities and expertise created by this SI are finding use in LLNL programmatic applications. Finally, and most importantly, this SI project has brought to LLNL the human talent on who will be the ensuring the further success of computational biology at this laboratory.

  14. Strategic Computing Computer Vision: Taking Image Understanding To The Next Plateau

    NASA Astrophysics Data System (ADS)

    Simpson, R. L., Jr.

    1987-06-01

    The overall objective of the Strategic Computing (SC) Program of the Defense Advanced Research Projects Agency (DARPA) is to develop and demonstrate a new generation of machine intelligence technology which can form the basis for more capable military systems in the future and also maintain a position of world leadership for the US in computer technology. Begun in 1983, SC represents a focused research strategy for accelerating the evolution of new technology and its rapid prototyping in realistic military contexts. Among the very ambitious demonstration prototypes being developed within the SC Program are: 1) the Pilot's Associate which will aid the pilot in route planning, aerial target prioritization, evasion of missile threats, and aircraft emergency safety procedures during flight; 2) two battle management projects one for the for the Army, which is just getting started, called the AirLand Battle Management program (ALBM) which will use knowledge-based systems technology to assist in the generation and evaluation of tactical options and plans at the Corps level; 3) the other more established program for the Navy is the Fleet Command Center Battle Management Program (FCCBIVIP) at Pearl Harbor. The FCCBMP is employing knowledge-based systems and natural language technology in a evolutionary testbed situated in an operational command center to demonstrate and evaluate intelligent decision-aids which can assist in the evaluation of fleet readiness and explore alternatives during contingencies; and 4) the Autonomous Land Vehicle (ALV) which integrates in a major robotic testbed the technologies for dynamic image understanding, knowledge-based route planning with replanning during execution, hosted on new advanced parallel architectures. The goal of the Strategic Computing computer vision technology base (SCVision) is to develop generic technology that will enable the construction of complete, robust, high performance image understanding systems to support a wide

  15. The Soviet political campaign against the U. S. Strategic Defense Initiative

    SciTech Connect

    Clark, M.T.

    1989-01-01

    The thesis of this dissertation is that the Soviet political campaign against the U.S. Strategic Defense Initiative (SDI) is designed to prevent the United States from deploying a ballistic missile defense (BMD) system capable of reducing the imbalance in U.S.-Soviet strategic nuclear force (SNF) vulnerabilities. The thesis is examined in two parts: (1) background on Soviet capabilities for political operations; and (2) the political campaign against SDI. The preferred Soviet objective in opposing SDI has remained for the U.S. to reach a decision on its own to suspend deployment of BMD, and to restrict and reduce the SDI research and development program. Soviet arms control proposals on SDI that asymmetrically affect U.S. and Soviet strategic defense programs are examined. U.S. concessions to extreme Soviet proposals have altered the original rationale for SDI. Rather than being a non-negotiable instrument to bring about a defense-dominant deterrence regime, SDI subsequently became insurance, after an agreement has been reached on reducing or eliminating ballistic missiles, against accidental or unauthorized launches. Finally, two case studies that impact SDI are examined. Soviet efforts to use the ABM Treaty interpretation dispute and violations issues to its advantage against SDI are considered.

  16. Scientific Computing Strategic Plan for the Idaho National Laboratory

    SciTech Connect

    Whiting, Eric Todd

    2015-09-01

    Scientific computing is a critical foundation of modern science. Without innovations in the field of computational science, the essential missions of the Department of Energy (DOE) would go unrealized. Taking a leadership role in such innovations is Idaho National Laboratory’s (INL’s) challenge and charge, and is central to INL’s ongoing success. Computing is an essential part of INL’s future. DOE science and technology missions rely firmly on computing capabilities in various forms. Modeling and simulation, fueled by innovations in computational science and validated through experiment, are a critical foundation of science and engineering. Big data analytics from an increasing number of widely varied sources is opening new windows of insight and discovery. Computing is a critical tool in education, science, engineering, and experiments. Advanced computing capabilities in the form of people, tools, computers, and facilities, will position INL competitively to deliver results and solutions on important national science and engineering challenges. A computing strategy must include much more than simply computers. The foundational enabling component of computing at many DOE national laboratories is the combination of a showcase like data center facility coupled with a very capable supercomputer. In addition, network connectivity, disk storage systems, and visualization hardware are critical and generally tightly coupled to the computer system and co located in the same facility. The existence of these resources in a single data center facility opens the doors to many opportunities that would not otherwise be possible.

  17. Success factors for strategic change initiatives: a qualitative study of healthcare administrators' perspectives.

    PubMed

    Kash, Bita Arbab; Spaulding, Aaron; Johnson, Christopher E; Gamm, Larry

    2014-01-01

    Success factors related to the implementation of change initiatives are well documented and discussed in the management literature, but they are seldom studied in healthcare organizations engaged in multiple strategic change initiatives. The purpose of this study was to identify key success factors related to implementation of change initiatives based on rich qualitative data gathered from health leader interviews at two large health systems implementing multiple change initiatives. In-depth personal interviews with 61 healthcare leaders in the two large systems were conducted and inductive qualitative analysis was employed to identify success factors associated with 13 change initiatives. Results from this analysis were compared to success factors identified in the literature, and generalizations were drawn that add significantly to the management literature, especially to that in the healthcare sector. Ten specific success factors were identified for the implementation of change initiatives. The top three success factors were (1) culture and values, (2) business processes, and (3) people and engagement. Two of the identified success factors are unique to the healthcare sector and not found in the literature on change models: service quality and client satisfaction (ranked fourth of 10) and access to information (ranked ninth). Results demonstrate the importance of human resource functions, alignment of culture and values with change, and business processes that facilitate effective communication and access to information to achieve many change initiatives. The responses also suggest opportunities for leaders of healthcare organizations to more formally recognize the degree to which various change initiatives are dependent on one another.

  18. Strategic Computing. New-Generation Computing Technology: A Strategic Plan for Its Development and Application to Critical Problems in Defense

    DTIC Science & Technology

    1983-10-28

    Computing. By seizing an opportunity to leverage recent advances in artificial intelligence, computer science, and microelectronics, the Agency plans...occurred in many separated areas of artificial intelligence, computer science, and microelectronics. Advances in "expert system" technology now...and expert knowledge o Advances in Artificial Intelligence: Mechanization of speech recognition, vision, and natural language understanding. o

  19. Strategizing Computer-Supported Collaborative Learning toward Knowledge Building

    ERIC Educational Resources Information Center

    Mukama, Evode

    2010-01-01

    The purpose of this paper is to explore how university students can develop knowledge in small task-based groups while acquiring hands-on computer skills. Inspired by the sociocultural perspective, this study presents a theoretical framework on co-construction of knowledge and on computer-supported collaborative learning. The participants were…

  20. Strategizing Computer-Supported Collaborative Learning toward Knowledge Building

    ERIC Educational Resources Information Center

    Mukama, Evode

    2010-01-01

    The purpose of this paper is to explore how university students can develop knowledge in small task-based groups while acquiring hands-on computer skills. Inspired by the sociocultural perspective, this study presents a theoretical framework on co-construction of knowledge and on computer-supported collaborative learning. The participants were…

  1. A Quantitative Study of the Relationship between Leadership Practice and Strategic Intentions to Use Cloud Computing

    ERIC Educational Resources Information Center

    Castillo, Alan F.

    2014-01-01

    The purpose of this quantitative correlational cross-sectional research study was to examine a theoretical model consisting of leadership practice, attitudes of business process outsourcing, and strategic intentions of leaders to use cloud computing and to examine the relationships between each of the variables respectively. This study…

  2. A Quantitative Study of the Relationship between Leadership Practice and Strategic Intentions to Use Cloud Computing

    ERIC Educational Resources Information Center

    Castillo, Alan F.

    2014-01-01

    The purpose of this quantitative correlational cross-sectional research study was to examine a theoretical model consisting of leadership practice, attitudes of business process outsourcing, and strategic intentions of leaders to use cloud computing and to examine the relationships between each of the variables respectively. This study…

  3. ONE Nano: NIEHS's strategic initiative on the health and safety effects of engineered nanomaterials.

    PubMed

    Schug, Thaddeus T; Johnson, Anne F; Balshaw, David M; Garantziotis, Stavros; Walker, Nigel J; Weis, Christopher; Nadadur, Srikanth S; Birnbaum, Linda S

    2013-04-01

    The past decade has seen tremendous expansion in the production and application of engineered nanomaterials (ENMs). The unique properties that make ENMs useful in the marketplace also make their interactions with biological systems difficult to anticipate and critically important to explore. Currently, little is known about the health effects of human exposure to these materials. As part of its role in supporting the National Nanotechnology Initiative, the National Institute of Environmental Health Sciences (NIEHS) has developed an integrated, strategic research program-"ONE Nano"-to increase our fundamental understanding of how ENMs interact with living systems, to develop predictive models for quantifying ENM exposure and assessing ENM health impacts, and to guide the design of second-generation ENMs to minimize adverse health effects. The NIEHS's research investments in ENM health and safety include extramural grants and grantee consortia, intramural research activities, and toxicological studies being conducted by the National Toxicology Program (NTP). These efforts have enhanced collaboration within the nanotechnology research community and produced toxicological profiles for selected ENMs, as well as improved methods and protocols for conducting in vitro and in vivo studies to assess ENM health effects. By drawing upon the strengths of the NIEHS's intramural, extramural, and NTP programs and establishing productive partnerships with other institutes and agencies across the federal government, the NIEHS's strategic ONE Nano program is working toward new advances to improve our understanding of the health impacts of engineered nanomaterials and support the goals of the National Nanotechnology Initiative.

  4. Washington Clinical Laboratory Initiative: a vision for collaboration and strategic planning for an integrated laboratory system.

    PubMed

    Counts, J M

    2001-01-01

    This article addresses the importance of public health, hospital, and clinical laboratories in the role of patient care, disease prevention, and surveillance. It also focuses on the coordination and planning that needs to take place between these institutions in order to develop a more cost-effective and responsive laboratory delivery system. The Washington Clinical Laboratory Initiative is an innovative state initiative illustrating that coordinated and integrated strategic planning of public and private sector laboratories can be accomplished within a state. It also has increased interaction, collaboration, and communication between health practitioners, health plans, hospitals, laboratories, government agencies, and academicians. This accomplishment has enabled the establishment of public policy concerning laboratory reimbursement and development of standards of laboratory practice.

  5. A Study on Strategic Provisioning of Cloud Computing Services

    PubMed Central

    Rejaul Karim Chowdhury, Md

    2014-01-01

    Cloud computing is currently emerging as an ever-changing, growing paradigm that models “everything-as-a-service.” Virtualised physical resources, infrastructure, and applications are supplied by service provisioning in the cloud. The evolution in the adoption of cloud computing is driven by clear and distinct promising features for both cloud users and cloud providers. However, the increasing number of cloud providers and the variety of service offerings have made it difficult for the customers to choose the best services. By employing successful service provisioning, the essential services required by customers, such as agility and availability, pricing, security and trust, and user metrics can be guaranteed by service provisioning. Hence, continuous service provisioning that satisfies the user requirements is a mandatory feature for the cloud user and vitally important in cloud computing service offerings. Therefore, we aim to review the state-of-the-art service provisioning objectives, essential services, topologies, user requirements, necessary metrics, and pricing mechanisms. We synthesize and summarize different provision techniques, approaches, and models through a comprehensive literature review. A thematic taxonomy of cloud service provisioning is presented after the systematic review. Finally, future research directions and open research issues are identified. PMID:25032243

  6. A study on strategic provisioning of cloud computing services.

    PubMed

    Whaiduzzaman, Md; Haque, Mohammad Nazmul; Rejaul Karim Chowdhury, Md; Gani, Abdullah

    2014-01-01

    Cloud computing is currently emerging as an ever-changing, growing paradigm that models "everything-as-a-service." Virtualised physical resources, infrastructure, and applications are supplied by service provisioning in the cloud. The evolution in the adoption of cloud computing is driven by clear and distinct promising features for both cloud users and cloud providers. However, the increasing number of cloud providers and the variety of service offerings have made it difficult for the customers to choose the best services. By employing successful service provisioning, the essential services required by customers, such as agility and availability, pricing, security and trust, and user metrics can be guaranteed by service provisioning. Hence, continuous service provisioning that satisfies the user requirements is a mandatory feature for the cloud user and vitally important in cloud computing service offerings. Therefore, we aim to review the state-of-the-art service provisioning objectives, essential services, topologies, user requirements, necessary metrics, and pricing mechanisms. We synthesize and summarize different provision techniques, approaches, and models through a comprehensive literature review. A thematic taxonomy of cloud service provisioning is presented after the systematic review. Finally, future research directions and open research issues are identified.

  7. High Productivity Computing Systems and Competitiveness Initiative

    DTIC Science & Technology

    2007-07-01

    Accumulated savings as a result of Intel architecture migration. Graphic cour- tesy of Intel Corporation. 64 16 Second Annual High Performance Computing...fourth year, grants large blocks of computing time to proposals with great potential for breakthrough discoveries. For fiscal year 2006, 18.2 million... fiscal year 2007, DOE will dramatically expand the amount of computing time it will make available to 95 million hours. SciDac2: $60 Million A Year

  8. SDI (Strategic Defense Initiative) and the Soviet defense burden. Interim report

    SciTech Connect

    Hildebrandt, G.G.

    1988-12-01

    The Soviets' response to the Strategic Defense Initiative (SDI) must be understood within the context of their deteriorating economic situation and need to modernize their economy. This Note evaluates the defense burden to the Soviets of both an offsetting and an emulation response to the U.S. SDI effort. The analysis is conducted within the context of General Secretary Gorbachev's modernization program, which is designed to increase the productivity of economic resources. The analysis suggests that the Soviets can partially offset a U.S. SDI effort with a ruble expenditure that is a small percentage of current defense spending. Although the Soviets may regard such a response as unsatisfactory, it is important to consider the striking contrast compared with the burden of an emulation response. The author hypothesizes, therefore, that the Soviets will choose not to directly emulate the U.S. SDI activities, at least until they have modernized their technical-economic base.

  9. Strategic Defense Initiative Demonstration/Validation program environmental assessment. Exoatmospheric reentry vehicle interception system (ERIS)

    SciTech Connect

    Brown, G.

    1987-08-01

    The Strategic Defense Initiative Organization (SDIO) and its proponents (the U.S. Army and the U.S. Air Force) plan to conduct Demonstration/Validation tests of the ERIS technology. These tests will demonstrate the ability of the technology to perform the required tasks, and validate a future decision whether to proceed with Full-Scale Development. Demonstration/Validation tests would be conducted at the Arnold Engineering Development Center, National Test Facility, Nevada Test Site, Harry Diamond Laboratories, Vandenberg Air Force Base/Western Test Range, U.S. Army Kwajalein Atoll, U.S. Naval Pacific Missile Range at Barking Sands, and contractor facilities. Tests would include analyses, simulations, component/assembly tests, and flight tests. This document addresses the potential environmental consequences of the Demonstration/Validation testing of the ERIS technology.

  10. ONE Nano: NIEHS’s Strategic Initiative on the Health and Safety Effects of Engineered Nanomaterials

    PubMed Central

    Johnson, Anne F.; Balshaw, David M.; Garantziotis, Stavros; Walker, Nigel J.; Weis, Christopher; Nadadur, Srikanth S.; Birnbaum, Linda S.

    2013-01-01

    Background: The past decade has seen tremendous expansion in the production and application of engineered nanomaterials (ENMs). The unique properties that make ENMs useful in the marketplace also make their interactions with biological systems difficult to anticipate and critically important to explore. Currently, little is known about the health effects of human exposure to these materials. Objectives: As part of its role in supporting the National Nanotechnology Initiative, the National Institute of Environmental Health Sciences (NIEHS) has developed an integrated, strategic research program—“ONE Nano”—to increase our fundamental understanding of how ENMs interact with living systems, to develop predictive models for quantifying ENM exposure and assessing ENM health impacts, and to guide the design of second-generation ENMs to minimize adverse health effects. Discussion: The NIEHS’s research investments in ENM health and safety include extramural grants and grantee consortia, intramural research activities, and toxicological studies being conducted by the National Toxicology Program (NTP). These efforts have enhanced collaboration within the nanotechnology research community and produced toxicological profiles for selected ENMs, as well as improved methods and protocols for conducting in vitro and in vivo studies to assess ENM health effects. Conclusion: By drawing upon the strengths of the NIEHS’s intramural, extramural, and NTP programs and establishing productive partnerships with other institutes and agencies across the federal government, the NIEHS’s strategic ONE Nano program is working toward new advances to improve our understanding of the health impacts of engineered nanomaterials and support the goals of the National Nanotechnology Initiative. PMID:23407114

  11. ACM TOMS replicated computational results initiative

    DOE PAGES

    Heroux, Michael Allen

    2015-06-03

    In this study, the scientific community relies on the peer review process for assuring the quality of published material, the goal of which is to build a body of work we can trust. Computational journals such as The ACM Transactions on Mathematical Software (TOMS) use this process for rigorously promoting the clarity and completeness of content, and citation of prior work. At the same time, it is unusual to independently confirm computational results.

  12. ACM TOMS replicated computational results initiative

    SciTech Connect

    Heroux, Michael Allen

    2015-06-03

    In this study, the scientific community relies on the peer review process for assuring the quality of published material, the goal of which is to build a body of work we can trust. Computational journals such as The ACM Transactions on Mathematical Software (TOMS) use this process for rigorously promoting the clarity and completeness of content, and citation of prior work. At the same time, it is unusual to independently confirm computational results.

  13. SDIO (Strategic Defense Initiative Office) Technical Information Management Center Bibliography of unclassified reports: January-December 1985

    SciTech Connect

    Not Available

    1985-12-01

    This bibliography lists to Strategic Defense Initiative Organization Technical Information Management Centers holdings of publications pertaining to such topics as Liquid Droplet Radiators, Relay Lasers, Precision-Guided Munitions, Short-Wavelength Chemical Laser, Electromagnetic Rocket Guns, Space Weapon, and Antimissile Defense Systems.

  14. Creating a strategic plan for configuration management using computer aided software engineering (CASE) tools

    SciTech Connect

    Smith, P.R.; Sarfaty, R.

    1993-05-01

    This paper provides guidance in the definition, documentation, measurement, enhancement of processes, and validation of a strategic plan for configuration management (CM). The approach and methodology used in establishing a strategic plan is the same for any enterprise, including the Department of Energy (DOE), commercial nuclear plants, the Department of Defense (DOD), or large industrial complexes. The principles and techniques presented are used world wide by some of the largest corporations. The authors used industry knowledge and the areas of their current employment to illustrate and provide examples. Developing a strategic configuration and information management plan for DOE Idaho Field Office (DOE-ID) facilities is discussed in this paper. A good knowledge of CM principles is the key to successful strategic planning. This paper will describe and define CM elements, and discuss how CM integrates the facility`s physical configuration, design basis, and documentation. The strategic plan does not need the support of a computer aided software engineering (CASE) tool. However, the use of the CASE tool provides a methodology for consistency in approach, graphics, and database capability combined to form an encyclopedia and a method of presentation that is easily understood and aids the process of reengineering. CASE tools have much more capability than those stated above. Some examples are supporting a joint application development group (JAD) to prepare a software functional specification document and, if necessary, provide the capability to automatically generate software application code. This paper briefly discusses characteristics and capabilities of two CASE tools that use different methodologies to generate similar deliverables.

  15. Comparison and alignment of an academic medical center's strategic goals with ASHP initiatives.

    PubMed

    Engels, Melanie J; Chaffee, Bruce W; Clark, John S

    2015-12-01

    An academic medical center's strategic goals were compared and aligned with the 2015 ASHP Health-System Pharmacy Initiative and the Pharmacy Practice Model Initiative (PPMI). The department's pharmacy practice model steering committee identified potential solutions to narrow prioritized gaps using a modified nominal group technique and a multivoting dot technique. Five priority solutions were identified and assigned to work groups to develop business plans, which included admission medication history and reconciliation for high-risk patients and those with complex medication regimens, pharmacist provision of discharge counseling to high-risk patients and those with complex medication regimens, improved measurement and reporting of the impact of PPMI programs on patient outcomes, implementation of a departmentwide formalized peer review and evaluation process, and the greeting of every patient at some time during his or her visit by a pharmacy team member. Stakeholders evaluated the business plans based on feasibility, financial return on investment, and anticipated safety enhancements. The solution that received the highest priority ranking and was subsequently implemented was "improved measurement and reporting of the impact of PPMI programs on patient outcomes." A defined process was followed for identifying gaps among current practices at an academic medical center and the 2015 ASHP Health-System Pharmacy Initiative and the PPMI. A key priority to better document the impact of pharmacists on patient care was identified for our department by using a nominal group technique brainstorming process and a multivoting dot technique and creating standardized business plans for five potential priority projects. Copyright © 2015 by the American Society of Health-System Pharmacists, Inc. All rights reserved.

  16. Improving the Reading Comprehension of Middle School Students with Disabilities through Computer-Assisted Collaborative Strategic Reading

    ERIC Educational Resources Information Center

    Kim, Ae-Hwa; Vaughn, Sharon; Klingner, Janette K.; Woodruff, Althea L.; Reutebuch, Colleen Klein; Kouzekanani, Kamiar

    2006-01-01

    This study investigated the effects of computer-assisted comprehension practice using a researcher-developed computer program, Computer-Assisted Collaborative Strategic Reading (CACSR), with students who had disabilities. Two reading/language arts teachers and their 34 students with disabilities participated. Students in the intervention group…

  17. Improving the Reading Comprehension of Middle School Students with Disabilities through Computer-Assisted Collaborative Strategic Reading

    ERIC Educational Resources Information Center

    Kim, Ae-Hwa; Vaughn, Sharon; Klingner, Janette K.; Woodruff, Althea L.; Reutebuch, Colleen Klein; Kouzekanani, Kamiar

    2006-01-01

    This study investigated the effects of computer-assisted comprehension practice using a researcher-developed computer program, Computer-Assisted Collaborative Strategic Reading (CACSR), with students who had disabilities. Two reading/language arts teachers and their 34 students with disabilities participated. Students in the intervention group…

  18. Linking Student Engagement and Strategic Initiatives: Using NSSE Results to Inform Campus Action

    ERIC Educational Resources Information Center

    Doherty, Kathryn

    2007-01-01

    Towson University (TU) is in a period of growth in both students and facilities. To guide this growth, TU relies on its strategic plan, Towson 2010, to focus its strategic decisions through 2010. Release of the National Survey of Student Engagement (NSSE) data for 2005 coincided with a call for academic excellence and accelerated growth at Towson…

  19. A strategic crossflow filtration methodology for the initial purification of promegapoietin from inclusion bodies.

    PubMed

    Ledung, Erika; Eriksson, Per-Olov; Oscarsson, Sven

    2009-04-20

    A novel crossflow filtration methodology is demonstrated for the initial purification of the therapeutic protein, promegapoietin-1a (PMP), produced as inclusion bodies (IBs) in a recombinant Escherichia coli bioprocess. Two strategic separation steps were performed by utilizing a filtration unit with a 1000 kDa polyethersulphone membrane. The first step, aiming for separation of soluble contaminants, resulted in a 50% reduction of the host cell proteins, quantified by total amino acid analysis and a 70% reduction of all DNA, quantified by fluorometry, when washing the particulate material with a 10mM EDTA in 50mM phosphate buffer, pH 8. The second step, aiming for separation of particulate contaminants from solubilized IBs, resulted in a 97-99.5% reduction of endotoxin, used as a marker for cell debris, and was quantified by the kinetic turbidimetric LAL endotoxin assay. The overall PMP yield was 58% and 33% respectively for the two solubilizations investigated, guanidine hydrochloride and arginine, as measured by RP-HPLC. The scope was also to investigate the physical characteristics of the intermediate product/s with regard to the choice of IB solvent. Preliminary results from circular dichroism spectroscopy measurements indicate that the protein secondary structure was restored when arginine was used in the second step.

  20. INCCA: Integrated Climate and Carbon Final Report of the LLNL LDRD Strategic Initiative

    SciTech Connect

    Thompson, S L

    2004-02-13

    The INCCA (Integrated Climate and Carbon) strategic initiative developed and applied the ability to simulate the fate and climate impact of fossil fuel-derived carbon dioxide (CO{sub 2}) on a global scale. Coupled climate and carbon cycle modeling like that of INCCA is required to understand and predict the future environmental impacts of fossil fuel burning. At present, atmospheric CO{sub 2} concentrations are prescribed, not simulated, in large climate models. Credible simulations of the entire climate system, however, need to predict time-evolving climate forcing using anthropogenic emissions as the fundamental input. Predicting atmospheric CO{sub 2} concentrations represents a substantial scientific advance because there are large natural sources and sinks of carbon that are likely to change as a result of climate change. Both terrestrial (e.g., vegetation on land) and oceanic components of the carbon cycle are known to be sensitive to climate change. Estimates of the amount of man-made CO{sub 2} that will accumulate in the atmosphere depend on understanding the carbon cycle. For this reason, models that use CO{sub 2} emissions, not prescribed atmospheric concentrations, as fundamental inputs are required to directly address greenhouse-related questions of interest to policymakers.

  1. Summary and evaluation of the Strategic Defense Initiative Space Power Architecture Study

    NASA Technical Reports Server (NTRS)

    Edenburn, M. (Editor); Smith, J. M. (Editor)

    1989-01-01

    The Space Power Architecture Study (SPAS) identified and evaluated power subsystem options for multimegawatt electric (MMWE) space based weapons and surveillance platforms for the Strategic Defense Initiative (SDI) applications. Steady state requirements of less than 1 MMWE are adequately covered by the SP-100 nuclear space power program and hence were not addressed in the SPAS. Four steady state power systems less than 1 MMWE were investigated with little difference between them on a mass basis. The majority of the burst power systems utilized H(2) from the weapons and were either closed (no effluent), open (effluent release) or steady state with storage (no effluent). Closed systems used nuclear or combustion heat source with thermionic, Rankine, turboalternator, fuel cell and battery conversion devices. Open systems included nuclear or combustion heat sources using turboalternator, magnetohydrodynamic, fuel cell or battery power conversion devices. The steady state systems with storage used the SP-100 or Star-M reactors as energy sources and flywheels, fuel cells or batteries to store energy for burst applications. As with other studies the open systems are by far the lightest, most compact and simplist (most reliable) systems. However, unlike other studies the SPAS studied potential platform operational problems caused by effluents or vibration.

  2. The ALMA computing project: initial commissioning

    NASA Astrophysics Data System (ADS)

    Glendenning, B. E.; Raffi, G.

    2008-08-01

    The Atacama Large Millimeter/Submillimeter Array (ALMA) is a large radio interferometric telescope consisting of 66 antennas with variable positions, to be located at the Chajnantor 5000mat a high site (5000m) in Chile. ALMA commissioning has now started with the arrival of several antennas in Chile and will continue for the next 4 years. The ALMA Software was from the beginning has been developed as an end-to-end system including: proposal preparation, dynamic scheduling, instrument control, data handling and formatting, data archiving and retrieval, automatic and manual data processing systems, and support for observatory operations. This presentation will expand mostly on ALMA software aspects issues on which we are concentrating in this phase: management, procedures, testing and validation. While software development was based on a common software infrastructure (ALMA Common Software - ACS) from the beginning, end-to-end testing was limited by the hardware available, and was possible for years until recently only on computer models. Although the control software was available early in prototype stand-alone form to support testing of prototypes antennas, it was only recently that dynamic interferometry was reached and software could be tested end to end with a somewhat stable hardware platform. The lessons learned so far will be explained, in particular the need for a realistic validation environment, the balance to be achieved between incremental development and the needed for stability and usability, and the way to achieve all the above with a development team distributed over three four continents. Some general lessons can be drown drawn on the potential conflicts between software and system (hardware) testing, or in other words on the danger in taking short-cuts in software testing and validation.

  3. The Reagan strategic defense initiative: A technical, political, and arms control assessment

    SciTech Connect

    Drell, S.D.; Farley, P.J.; Holloway, D.

    1985-01-01

    This study examines SDI in the overall context of the U.S.-Soviet strategic posture and concludes with recommendations on how best to integrate SDI research into the requirements of the ABM commitments.

  4. 15 CFR 1160.22 - Goal of the Strategic Partnership initiative.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... benefits of forming Strategic Partnerships among firms representing the entire food chain of specific... private sector in key technologies at which the stakeholder industries in the food chain for each...

  5. 15 CFR 1160.22 - Goal of the Strategic Partnership initiative.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... benefits of forming Strategic Partnerships among firms representing the entire food chain of specific... private sector in key technologies at which the stakeholder industries in the food chain for each...

  6. 15 CFR 1160.22 - Goal of the Strategic Partnership initiative.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... benefits of forming Strategic Partnerships among firms representing the entire food chain of specific... private sector in key technologies at which the stakeholder industries in the food chain for each...

  7. 15 CFR 1160.22 - Goal of the Strategic Partnership initiative.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... benefits of forming Strategic Partnerships among firms representing the entire food chain of specific... private sector in key technologies at which the stakeholder industries in the food chain for each...

  8. Strategic laparoscopic surgery for improved cosmesis in general and bariatric surgery: analysis of initial 127 cases.

    PubMed

    Nguyen, Ninh T; Smith, Brian R; Reavis, Kevin M; Nguyen, Xuan-Mai T; Nguyen, Brian; Stamos, Michael J

    2012-05-01

    Strategic laparoscopic surgery for improved cosmesis (SLIC) is a less invasive surgical approach than conventional laparoscopic surgery. The aim of this study was to examine the feasibility and safety of SLIC for general and bariatric surgical operations. Additionally, we compared the outcomes of laparoscopic sleeve gastrectomy with those performed by the SLIC technique. In an academic medical center, from April 2008 to December 2010, 127 patients underwent SLIC procedures: 38 SLIC cholecystectomy, 56 SLIC gastric banding, 26 SLIC sleeve gastrectomy, 1 SLIC gastrojejunostomy, and 6 SLIC appendectomy. SLIC sleeve gastrectomy was initially performed through a single 4.0-cm supraumbilical incision with extraction of the gastric specimen through the same incision. The technique evolved to laparoscopic incisions that were all placed within the umbilicus and suprapubic region. There were no 30-day or in-hospital mortalities or 30-day re-admissions or re-operations. For SLIC cholecystectomy, gastric banding, appendectomy, and gastrojejunostomy, conversion to conventional laparoscopy occurred in 5.3%, 5.4%, 0%, and 0%, respectively; there were no major or minor postoperative complications. For SLIC sleeve gastrectomy, there were no significant differences in mean operative time and length of hospital stay compared with laparoscopic sleeve gastrectomy; 1 (3.8%) of 26 SLIC patients required conversion to five-port laparoscopy. There were no major complications. Minor complications occurred in 7.7% in the SLIC sleeve group versus 8.3% in the laparoscopic sleeve group. SLIC in general and bariatric operations is technically feasible, safe, and associated with a low rate of conversion to conventional laparoscopy. Compared with laparoscopic sleeve gastrectomy, SLIC sleeve gastrectomy can be performed without a prolonged operative time with comparable perioperative outcomes.

  9. Application of the Modular Command and Control Evaluation Structure to a Strategic Defense Initiative command and control system. Master's thesis

    SciTech Connect

    Kramer, G.K.

    1987-03-01

    This thesis focuses on relating a generic evaluation structure, the Modular Command and Control Evaluation Structure (MCES), to the battle management (BM) and command, control and communication (C3) issues of the Strategic Defense Initiative (SDI). To do this, the area of SDI battle management, command and control (C2), and communications are reviewed and explained as well as the MCES. This provides useful descriptive analysis required for identifying and measuring proposed BM/C3 architectures.

  10. A Study to Determine the Optimal Strategic Planning Process for Controlling and Coordinating the In-House Development of an Integrated Computer- Supported Hospital Information System

    DTIC Science & Technology

    1982-05-01

    This study examines Strategic Planning concepts and how they relate to the development of Hospital Information Systems. The author recommends that... Strategic Planning methods be utilized in the development of Hospital Information Systems, and provides guidance on how to do so. Keywords: Theses...Integrated information systems; Hospital administration; Computer networks; Information exchange; Health care; Strategic planning ; Information systems.

  11. Computing arrival times of firefighting resources for initial attack

    Treesearch

    Romain M. Mees

    1978-01-01

    Dispatching of firefighting resources requires instantaneous or precalculated decisions. A FORTRAN computer program has been developed that can provide a list of resources in order of computed arrival time for initial attack on a fire. The program requires an accurate description of the existing road system and a list of all resources available on a planning unit....

  12. Implications of the Strategic Defense Initiative for ABM (Anti-Ballistic Missile) Treaty. Professional paper

    SciTech Connect

    Schneiter, G.R.

    1986-02-01

    SDI is a current emphasis of the US strategic program, joining a considerable build-up in US strategic offensive forces. The US defense budget has now begun to reflect increases in research on technologies applicable to a space-based defense. And the United States has enlisted the endorsement of her NATO allies for at least the research portion of SDI. This article examines the effect of this new direction in US defense policy on strategic arms control. It will focus particularly on questions raised for the 1972 Anti-ballistic Missile (ABM) Treaty, in the eyes of many the principal lasting achievement of the era of detente. This Treaty, which bans a territorial defense against strategic ballistic missiles and severely constrains other ABM activities, is the only one of the SALT agreements still legally in force. The article first reviews the strategic forces and programs of the United States and Soviet Union, with emphasis on defensive forces. It then addresses the background and current status of the ABM Treaty. Finally, it identifies and discusses the critical issues with regard to the future of the ABM Treaty.

  13. Strategic Engagement of Technical Surge Capacity for Intensified Polio Eradication Initiative in Nigeria, 2012-2015.

    PubMed

    Yehualashet, Yared G; Mkanda, Pascal; Gasasira, Alex; Erbeto, Tesfaye; Onimisi, Anthony; Horton, Janet; Banda, Richard; Tegegn, Sisay G; Ahmed, Haruna; Afolabi, Oluwole; Wadda, Alieu; Vaz, Rui G; Nsubuga, Peter

    2016-05-01

    Following the 65th World Health Assembly (WHA) resolution on intensification of the Global Poliomyelitis Eradication Initiative (GPEI), the Nigerian government, with support from the World Health Organization (WHO) and other partners, implemented a number of innovative strategies to curb the transmission of wild poliovirus (WPV) in the country. One of the innovations successfully implemented since mid 2012 is the WHO's engagement of surge capacity personnel. The WHO reorganized its functional structure, adopted a transparent recruitment and deployment process, provided focused technical and management training, and applied systematic accountability framework to successfully manage the surge capacity project in close collaboration with the national counterparts and partners. The deployment of the surge capacity personnel was guided by operational and technical requirement analysis. Over 2200 personnel were engaged, of whom 92% were strategically deployed in 11 states classified as high risk on the basis of epidemiological risk analysis and compromised security. These additional personnel were directly engaged in efforts aimed at improving the performance of polio surveillance, vaccination campaigns, increased routine immunization outreach sessions, and strengthening partnership with key stakeholders at the operational level, including community-based organizations. Programmatic interventions were sustained in states in which security was compromised and the risk of polio was high, partly owing to the presence of the surge capacity personnel, who are engaged from the local community. Since mid-2012, significant programmatic progress was registered in the areas of polio supplementary immunization activities, acute flaccid paralysis surveillance, and routine immunization with the support of the surge capacity personnel. As of 19 June 2015, the last case of WPV was reported on 24 July 2014. The surge infrastructure has also been instrumental in building local capacity

  14. Strategic Engagement of Technical Surge Capacity for Intensified Polio Eradication Initiative in Nigeria, 2012–2015

    PubMed Central

    Yehualashet, Yared G.; Mkanda, Pascal; Gasasira, Alex; Erbeto, Tesfaye; Onimisi, Anthony; Horton, Janet; Banda, Richard; Tegegn, Sisay G.; Ahmed, Haruna; Afolabi, Oluwole; Wadda, Alieu; Vaz, Rui G.; Nsubuga, Peter

    2016-01-01

    Background. Following the 65th World Health Assembly (WHA) resolution on intensification of the Global Poliomyelitis Eradication Initiative (GPEI), the Nigerian government, with support from the World Health Organization (WHO) and other partners, implemented a number of innovative strategies to curb the transmission of wild poliovirus (WPV) in the country. One of the innovations successfully implemented since mid 2012 is the WHO's engagement of surge capacity personnel. Methods. The WHO reorganized its functional structure, adopted a transparent recruitment and deployment process, provided focused technical and management training, and applied systematic accountability framework to successfully manage the surge capacity project in close collaboration with the national counterparts and partners. The deployment of the surge capacity personnel was guided by operational and technical requirement analysis. Results. Over 2200 personnel were engaged, of whom 92% were strategically deployed in 11 states classified as high risk on the basis of epidemiological risk analysis and compromised security. These additional personnel were directly engaged in efforts aimed at improving the performance of polio surveillance, vaccination campaigns, increased routine immunization outreach sessions, and strengthening partnership with key stakeholders at the operational level, including community-based organizations. Discussion. Programmatic interventions were sustained in states in which security was compromised and the risk of polio was high, partly owing to the presence of the surge capacity personnel, who are engaged from the local community. Since mid-2012, significant programmatic progress was registered in the areas of polio supplementary immunization activities, acute flaccid paralysis surveillance, and routine immunization with the support of the surge capacity personnel. As of 19 June 2015, the last case of WPV was reported on 24 July 2014. The surge infrastructure has

  15. An Analysis of the Soviet Response to the Strategic Defense Initiative (SDI).

    DTIC Science & Technology

    1987-04-01

    perspective. Schulyer Foerster provides an excellent bibliographical essay on Soviet defense policy that provides the reader a sampling of various schools...2002-, Vol. 4, No. 4 (August-September 1985), pp. 65-75. 19. Meyer, Stephen M. *Soviet Strategic Programmes and the U.S. SDI." Survival, Vol. 27, No. 6

  16. Strategic Planning for Educational Technology Initiatives in PK-12 Lutheran Schools

    ERIC Educational Resources Information Center

    Muth, Nicole

    2012-01-01

    Technology rich learning environments provide the potential for engaging, relevant, and personalized curricula that prepare students for 21st century careers. However, a lack of strategic planning by educators results in available technology not being used to its fullest potential. Several educational organizations have published guidelines for…

  17. The National Higher Education and Workforce Initiative: Forging Strategic Partnerships for Undergraduate Innovation and Workforce Development

    ERIC Educational Resources Information Center

    Business-Higher Education Forum, 2013

    2013-01-01

    This is the first in a series of Business-Higher Education Forum (BHEF) playbooks intended to assist companies, higher education institutions, private philanthropies, membership associations, professional societies, government agencies, and other stakeholders seeking to understand the potential value of investing in coordinated strategic,…

  18. Strategic Planning for Educational Technology Initiatives in PK-12 Lutheran Schools

    ERIC Educational Resources Information Center

    Muth, Nicole

    2012-01-01

    Technology rich learning environments provide the potential for engaging, relevant, and personalized curricula that prepare students for 21st century careers. However, a lack of strategic planning by educators results in available technology not being used to its fullest potential. Several educational organizations have published guidelines for…

  19. Eyeglass Large Aperture, Lightweight Space Optics FY2000 - FY2002 LDRD Strategic Initiative

    SciTech Connect

    Hyde, R

    2003-02-10

    differences in their requirements and implementations, the fundamental difficulty in utilizing large aperture optics is the same for all of these applications: It is extremely difficult to design large aperture space optics which are both optically precise and can meet the practical requirements for launch and deployment in space. At LLNL we have developed a new concept (Eyeglass) which uses large diffractive optics to solve both of these difficulties; greatly reducing both the mass and the tolerance requirements for large aperture optics. During previous LDRD-supported research, we developed this concept, built and tested broadband diffractive telescopes, and built 50 cm aperture diffraction-limited diffractive lenses (the largest in the world). This work is fully described in UCRL-ID-136262, Eyeglass: A Large Aperture Space Telescope. However, there is a large gap between optical proof-of-principle with sub-meter apertures, and actual 50 meter space telescopes. This gap is far too large (both in financial resources and in spacecraft expertise) to be filled internally at LLNL; implementation of large aperture diffractive space telescopes must be done externally using non-LLNL resources and expertise. While LLNL will never become the primary contractor and integrator for large space optical systems, our natural role is to enable these devices by developing the capability of producing very large diffractive optics. Accordingly, the purpose of the Large Aperture, Lightweight Space Optics Strategic Initiative was to develop the technology to fabricate large, lightweight diffractive lenses. The additional purpose of this Strategic Initiative was, of course, to demonstrate this lens-fabrication capability in a fashion compellingly enough to attract the external support necessary to continue along the path to full-scale space-based telescopes. During this 3 year effort (FY2000-FY2002) we have developed the capability of optically smoothing and diffractively-patterning thin meter

  20. Biomaterials and computation: a strategic alliance to investigate emergent responses of neural cells.

    PubMed

    Sergi, Pier Nicola; Cavalcanti-Adam, Elisabetta Ada

    2017-03-28

    Topographical and chemical cues drive migration, outgrowth and regeneration of neurons in different and crucial biological conditions. In the natural extracellular matrix, their influences are so closely coupled that they result in complex cellular responses. As a consequence, engineered biomaterials are widely used to simplify in vitro conditions, disentangling intricate in vivo behaviours, and narrowing the investigation on particular emergent responses. Nevertheless, how topographical and chemical cues affect the emergent response of neural cells is still unclear, thus in silico models are used as additional tools to reproduce and investigate the interactions between cells and engineered biomaterials. This work aims at presenting the synergistic use of biomaterials-based experiments and computation as a strategic way to promote the discovering of complex neural responses as well as to allow the interactions between cells and biomaterials to be quantitatively investigated, fostering a rational design of experiments.

  1. Initial Computations of Vertical Displacement Events with NIMROD

    NASA Astrophysics Data System (ADS)

    Bunkers, Kyle; Sovinec, C. R.

    2014-10-01

    Disruptions associated with vertical displacement events (VDEs) have potential for causing considerable physical damage to ITER and other tokamak experiments. We report on initial computations of generic axisymmetric VDEs using the NIMROD code [Sovinec et al., JCP 195, 355 (2004)]. An implicit thin-wall computation has been implemented to couple separate internal and external regions without numerical stability limitations. A simple rectangular cross-section domain generated with the NIMEQ code [Howell and Sovinec, CPC (2014)] modified to use a symmetry condition at the midplane is used to test linear and nonlinear axisymmetric VDE computation. As current in simulated external coils for large- R / a cases is varied, there is a clear n = 0 stability threshold which lies below the decay-index criterion for the current-loop model of a tokamak to model VDEs [Mukhovatov and Shafranov, Nucl. Fusion 11, 605 (1971)]; a scan of wall distance indicates the offset is due to the influence of the conducting wall. Results with a vacuum region surrounding a resistive wall will also be presented. Initial nonlinear computations show large vertical displacement of an intact simulated tokamak. This effort is supported by U.S. Department of Energy Grant DE-FG02-06ER54850.

  2. Human Resource Executives' Perceptions and Measurement of the Strategic Impact of Work/Life Initiatives

    ERIC Educational Resources Information Center

    Morris, Michael Lane; Heames, Joyce Thompson; McMillan, Heather S.

    2011-01-01

    Given the stresses associated with today's demanding workplaces, work/life (w/l) initiatives continue to grow in importance as an organizational development (OD) intervention. In a period of increasing accountability, it is important for scholars and practitioners to demonstrate how OD interventions, like w/l initiatives, can be used as a…

  3. Human Resource Executives' Perceptions and Measurement of the Strategic Impact of Work/Life Initiatives

    ERIC Educational Resources Information Center

    Morris, Michael Lane; Heames, Joyce Thompson; McMillan, Heather S.

    2011-01-01

    Given the stresses associated with today's demanding workplaces, work/life (w/l) initiatives continue to grow in importance as an organizational development (OD) intervention. In a period of increasing accountability, it is important for scholars and practitioners to demonstrate how OD interventions, like w/l initiatives, can be used as a…

  4. A strategic initiative to foster interprofessional collaboration: A case report using a men's healthy living programme.

    PubMed

    Gauthier, Alain P; Jbilou, Jalila

    2016-11-01

    Interprofessional collaboration (IPC) can be challenging, yet it has shown benefits for providers and patients. We examined the existing enablers and barriers to IPC at a local Community Health Center (CHC) and report on the existing types of IPC practice. We also report how implementing a men-sensitive healthy living programme united a team of health professionals/managers in attending to the needs of a population that to date had been largely underserved. A total of 16 employees were interviewed at the CHC. All respondents spoke positively of existing IPC and provided examples of existing collaborative practices. These CHC professionals (clinicians and managers) experienced greater intra- and extra-organisational collaborations as a result of experiencing a community-delivered programme. It also allowed the CHC professionals/managers to rethink the management and structure of collaborative practices and understand the needs and challenges of working with non-traditional partners (men and workplace-based managers). While our findings are context sensitive (case study design), they shed light on how uniting health professionals/managers around a challenging and non-traditional health issue (i.e., improving health in a hard-to-reach population subgroup) can strategically reduce resistance to collaborative practice development by strengthening team cohesion and fostering innovative interactions.

  5. NATO's anti-tactical ballistic-missile requirements and their relationship to the Strategic Defense Initiative. Interim report

    SciTech Connect

    Rubenson, D.; Bonomo, J.

    1987-12-01

    The report attempts to structure the broad range of issues affecting the potential development of anti-tactical ballistic missile (ATBM) systems by evaluating the relationship among NATO's potential needs for ATBMs, the technologies under development in the Strategic Defense Initiative (SDI) program, and the political constraints in the Federal Republic of Germany (FRG), where ATBMs would be deployed. The authors conclude that planners attempting to improve NATO's air defenses and those attempting to advance SDI research goals are faced with distinctly different problems. Since NATO's requirements have little connection to SDI, an ATBM system intended to advance SDI goals must be based almost entirely on SDI objectives and could cause controversy in the FRG. Conversely, the limited systems of most interest to NATO stand outside the political debate.

  6. Effects of scientific, political, and allied opposition to SDI (Strategic Defense Initiative) on national security. Student essay

    SciTech Connect

    McKie, F.

    1987-03-23

    The Strategic Defense Initiative (SDI) is an intensive research program aimed at determining whether there are cost-effective defensive technologies that could enhance deterrence, strengthen stability, and increase the security of the United States and its allies against ballistic missile nuclear attack. Since its inception in March 1983, opposition to the SDI program has been widely publicized by the media. The most prominent sources of such opposition have been members of the scientific, political, and Allied communities. The sources and rationale for this opposition, along with effects on calibre of support for SDI research efforts, congressional funding, and program changes in the SDI research schedule were examined. Information was gathered through a review of the literature.

  7. 75 FR 35076 - Division of Program Coordination, Planning, and Strategic Initiatives, Office of the Director...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-21

    ... proposed FY 2011 Common Fund initiatives: (1) NIH-HMO Research Network Collaboratory; (2) Health Economics... due to scheduling conflicts of Members. Information is also available on the Council of Council's home...

  8. Initial water quantification results using neutron computed tomography

    NASA Astrophysics Data System (ADS)

    Heller, A. K.; Shi, L.; Brenizer, J. S.; Mench, M. M.

    2009-06-01

    Neutron computed tomography is an important imaging tool in the field of non-destructive testing and in fundamental research for many engineering applications. Contrary to X-rays, neutrons can be attenuated by some light materials, such as hydrogen, but can penetrate many heavy materials. Thus, neutron computed tomography is useful in obtaining important three-dimensional information about a sample's interior structure and material properties that other traditional methods cannot provide. The neutron computed tomography system at the Pennsylvania State University's Radiation Science and Engineering Center is being utilized to develop a water quantification technique for investigation of water distribution in fuel cells under normal conditions. A hollow aluminum cylinder test sample filled with a known volume of water was constructed for purposes of testing the quantification technique. Transmission images of the test sample at different angles were easily acquired through the synthesis of a dedicated image acquisition computer driving a rotary table controller and an in-house developed synchronization software package. After data acquisition, Octopus (version 8.2) and VGStudio Max (version 1.2) were used to perform cross-sectional and three-dimensional reconstructions of the sample, respectively. The initial reconstructions and water quantification results are presented.

  9. Research initiatives for plug-and-play scientific computing.

    SciTech Connect

    McInnes, L. C.; Dahlgren, T.; Nieplocha, J.; Bernholdt, D.; Allan, B.; Armstrong, R.; Chavarria, D.; Elwasif, W.; Gorton, I.; Krishan, M.; Malony, A.; Norris, B.; Ray, J.; Shende, S.; Mathematics and Computer Science; LLNL; PNNL; ORNL; SNL; Univ. of Oregon

    2007-01-01

    This paper introduces three component technology initiatives within the SciDAC Center for Technology for Advanced Scientific Component Software (TASCS) that address ever-increasing productivity challenges in creating, managing, and applying simulation software to scientific discovery. By leveraging the Common Component Architecture (CCA), a new component standard for high-performance scientific computing, these initiatives tackle difficulties at different but related levels in the development of component-based scientific software: (1) deploying applications on massively parallel and heterogeneous architectures, (2) investigating new approaches to the runtime enforcement of behavioral semantics, and (3) developing tools to facilitate dynamic composition, substitution, and reconfiguration of component implementations and parameters, so that application scientists can explore tradeoffs among factors such as accuracy, reliability, and performance.

  10. Research initiatives for plug-and-play scientific computing

    NASA Astrophysics Data System (ADS)

    Curfman McInnes, Lois; Dahlgren, Tamara; Nieplocha, Jarek; Bernholdt, David; Allan, Ben; Armstrong, Rob; Chavarria, Daniel; Elwasif, Wael; Gorton, Ian; Kenny, Joe; Krishan, Manoj; Malony, Allen; Norris, Boyana; Ray, Jaideep; Shende, Sameer

    2007-07-01

    This paper introduces three component technology initiatives within the SciDAC Center for Technology for Advanced Scientific Component Software (TASCS) that address ever-increasing productivity challenges in creating, managing, and applying simulation software to scientific discovery. By leveraging the Common Component Architecture (CCA), a new component standard for high-performance scientific computing, these initiatives tackle difficulties at different but related levels in the development of component-based scientific software: (1) deploying applications on massively parallel and heterogeneous architectures, (2) investigating new approaches to the runtime enforcement of behavioral semantics, and (3) developing tools to facilitate dynamic composition, substitution, and reconfiguration of component implementations and parameters, so that application scientists can explore tradeoffs among factors such as accuracy, reliability, and performance.

  11. White paper: A vision for a computing initiative for MFE. Revised version

    SciTech Connect

    Cohen, R.H.; Crotinger, J.A.; Baldwin, D.E.

    1996-01-22

    The scientific base of magnetic fusion research comprises three capabilities: experimental research, theoretical understanding and computational modeling, with modeling providing the necessary link between the other two. The US now faces a budget climate that will preclude the construction of major new MFE facilities and limit MFE experimental operations. The situation is rather analogous to the one experienced by the DOE Defense Programs (DP), in which continued viability of the nuclear stockpile must be ensured despite the prohibition of underground experimental tests. DP is meeting this challenge, in part, by launching the Accelerated Strategic Computing Initiative (ASCI) to bring advanced algorithms and new hardware to bear on the problems of science-based stockpile stewardship (SBSS). ASCI has as its goal the establishment of a ``virtual testing`` capability, and it is expected to drive scientific software and hardware development through the next decade. The authors argue that a similar effort is warranted for the MFE program, that is, an initiative aimed at developing a comprehensive simulation capability for MFE, with the goal of enabling ``virtual experiments.`` It would play a role for MFE analogous to that played by present-day and future (ASCI) codes for nuclear weapons design and by LASNEX for ICF, and provide a powerful augmentation to constrained experimental programs. Developing a comprehensive simulation capability could provide an organizing theme for a restructured science-based MFE program. The code would become a central vehicle for integrating the accumulating science base. In the context the authors propose, the relationship would ultimately be reversed: computer simulation would become a primary vehicle for exploration, with experiments providing the necessary confirmatory evidence (or guidance for code improvements).

  12. Modeling strategic use of human computer interfaces with novel hidden Markov models

    PubMed Central

    Mariano, Laura J.; Poore, Joshua C.; Krum, David M.; Schwartz, Jana L.; Coskren, William D.; Jones, Eric M.

    2015-01-01

    Immersive software tools are virtual environments designed to give their users an augmented view of real-world data and ways of manipulating that data. As virtual environments, every action users make while interacting with these tools can be carefully logged, as can the state of the software and the information it presents to the user, giving these actions context. This data provides a high-resolution lens through which dynamic cognitive and behavioral processes can be viewed. In this report, we describe new methods for the analysis and interpretation of such data, utilizing a novel implementation of the Beta Process Hidden Markov Model (BP-HMM) for analysis of software activity logs. We further report the results of a preliminary study designed to establish the validity of our modeling approach. A group of 20 participants were asked to play a simple computer game, instrumented to log every interaction with the interface. Participants had no previous experience with the game's functionality or rules, so the activity logs collected during their naïve interactions capture patterns of exploratory behavior and skill acquisition as they attempted to learn the rules of the game. Pre- and post-task questionnaires probed for self-reported styles of problem solving, as well as task engagement, difficulty, and workload. We jointly modeled the activity log sequences collected from all participants using the BP-HMM approach, identifying a global library of activity patterns representative of the collective behavior of all the participants. Analyses show systematic relationships between both pre- and post-task questionnaires, self-reported approaches to analytic problem solving, and metrics extracted from the BP-HMM decomposition. Overall, we find that this novel approach to decomposing unstructured behavioral data within software environments provides a sensible means for understanding how users learn to integrate software functionality for strategic task pursuit. PMID

  13. Modeling strategic use of human computer interfaces with novel hidden Markov models.

    PubMed

    Mariano, Laura J; Poore, Joshua C; Krum, David M; Schwartz, Jana L; Coskren, William D; Jones, Eric M

    2015-01-01

    Immersive software tools are virtual environments designed to give their users an augmented view of real-world data and ways of manipulating that data. As virtual environments, every action users make while interacting with these tools can be carefully logged, as can the state of the software and the information it presents to the user, giving these actions context. This data provides a high-resolution lens through which dynamic cognitive and behavioral processes can be viewed. In this report, we describe new methods for the analysis and interpretation of such data, utilizing a novel implementation of the Beta Process Hidden Markov Model (BP-HMM) for analysis of software activity logs. We further report the results of a preliminary study designed to establish the validity of our modeling approach. A group of 20 participants were asked to play a simple computer game, instrumented to log every interaction with the interface. Participants had no previous experience with the game's functionality or rules, so the activity logs collected during their naïve interactions capture patterns of exploratory behavior and skill acquisition as they attempted to learn the rules of the game. Pre- and post-task questionnaires probed for self-reported styles of problem solving, as well as task engagement, difficulty, and workload. We jointly modeled the activity log sequences collected from all participants using the BP-HMM approach, identifying a global library of activity patterns representative of the collective behavior of all the participants. Analyses show systematic relationships between both pre- and post-task questionnaires, self-reported approaches to analytic problem solving, and metrics extracted from the BP-HMM decomposition. Overall, we find that this novel approach to decomposing unstructured behavioral data within software environments provides a sensible means for understanding how users learn to integrate software functionality for strategic task pursuit.

  14. Strategic compliance planning using the NO{sub x}COMP computer model

    SciTech Connect

    Baublis, D.; Frazier, W.; Killen, D.; Copolo, T.; Flynn, D.; Nelson, J.

    1997-09-01

    Strategic planning for NO{sub x} compliance becomes more important as the NO{sub x} emission limits are reduced further for Phase 2 of the Clean Air Act Amendments of 1990 (CAAA). Utilities in sensitive areas such as the Ozone Transport Region (OTR), or others which may be affected by the activities of the Ozone Transport Assessment Group (OTAG) may face still lower limits than the current Title 4, Phase 2 regulations. Effective compliance strategy development must take into account baseline NO{sub x} emissions, actual or future regulatory limits, emissions averaging and bubbling schemes, unit capacity factors and economic parameters, as well as the potential of various NO{sub x} control techniques under consideration. Stone and Webster has developed and used the NO{sub x}COMP technical/economic computer model to aid utilities in determining the least-cost, least-risk strategy for compliance with the NO{sub x} provisions of the CAAA. Designed specifically to be used throughout the implementation of a NO{sub x} compliance program, NO{sub x}COMP can be updated with post-modification data. By inputting actual cost and emissions performance information, the impact to the utility compliance program can be determined and the strategy adjusted accordingly. Better, or worse than expected, performance can be evaluated based on overall compliance cost. NO{sub x}COMP uses input directly from the major load forecasting programs such as ENPRO and PROMOD, and when combined with the actual NO{sub x} vs. load profile for each boiler, develops projections of baseline annual NO{sub x} emissions. Least-cost compliance plans are determined by evaluating all applicable technologies to each unit, allowing marginal costs to be generated. For each scenario, the optimal NO{sub x} technology for each unit and associated costs are developed.

  15. The Annie E. Casey Foundation's New Futures Initiative: Strategic Planning Guide. (Revised).

    ERIC Educational Resources Information Center

    Center for the Study of Social Policy, Washington, DC.

    Information in this guide is based on published research concerning effective strategies in dealing with at-risk youth. It was written for those communities invited to develop proposals under the Annie E. Casey Foundation's New Futures Initiative in an attempt to alleviate problems that compromise American children's futures. Each of three…

  16. Student Perceptions and Achievement in a University Blended Learning Strategic Initiative

    ERIC Educational Resources Information Center

    Owston, Ron; York, Dennis; Murtha, Susan

    2013-01-01

    Examined in this study is the relationship between student perceptions in blended learning courses and their in-course achievement. The research was conducted at a large urban university that embarked on a major initiative to scale-up blended learning across its campus. Student perceptions (N = 577) were assessed in four areas deemed important to…

  17. UCAN: A Four-State Rural Systemic Initiative. Year Four Annual Report; Year Five Strategic Plan.

    ERIC Educational Resources Information Center

    LLamas, Vicente J.

    The Utah, Colorado, Arizona, New Mexico-Rural Systemic Initiative (UCAN-RSI) supports systemic improvement in science, technology, and mathematics education for all rural students in the four states, focusing on schools that enroll large numbers of American Indian and Hispanic students. This document contains a report on UCAN's 4th year (September…

  18. Student Perceptions and Achievement in a University Blended Learning Strategic Initiative

    ERIC Educational Resources Information Center

    Owston, Ron; York, Dennis; Murtha, Susan

    2013-01-01

    Examined in this study is the relationship between student perceptions in blended learning courses and their in-course achievement. The research was conducted at a large urban university that embarked on a major initiative to scale-up blended learning across its campus. Student perceptions (N = 577) were assessed in four areas deemed important to…

  19. Strategic Defense Initiative Demonstration/Validation Program Environmental Assessment. Battle Management/Command and Control, and Communications (BM/C3),

    DTIC Science & Technology

    1987-08-01

    computational pover, information display, telecomunications , and decision aids required by Strategic Defense System commanders to control and manage their...technology 2. Simulations: The use of softvare models representing both the test article and the environment to determine performance abilities 3. Component

  20. Using a decade of data on medical student computer literacy for strategic planning.

    PubMed

    Seago, Brenda L; Schlesinger, Jeanne B; Hampton, Carol L

    2002-04-01

    From 1991 through 2000, incoming medical students (M-Is) at the School of Medicine at Virginia Commonwealth University have been surveyed with a written questionnaire on their computer literacy. The survey's purpose is to learn the students' levels of knowledge, skill, and experience with computer technology to guide instructional services and facilities. The questionnaire was administered during M-I orientation or mailed to students' homes after matriculation. It evolved from sixteen questions in 1991 to twenty-three questions in 2000, with fifteen questions common to all. The average survey response rate was 81% from an average of 177 students. Six major changes were introduced based on information collected from the surveys and advances in technology: production of CD-ROMs distributed to students containing required computer-based instructional programs, delivery of evaluation instruments to students via the Internet, modification of the lab to a mostly PC-based environment, development of an electronic curriculum Website, development of computerized examinations for medical students to prepare them for the computerized national board examinations, and initiation of a personal digital assistant (PDA) project for students to evaluate PDAs' usefulness in clinical settings. The computer literacy survey provides a snapshot of students' past and present use of technology and guidance for the development of services and facilities.

  1. Using a decade of data on medical student computer literacy for strategic planning

    PubMed Central

    Seago, Brenda L.; Schlesinger, Jeanne B.; Hampton, Carol L.

    2002-01-01

    Purpose: From 1991 through 2000, incoming medical students (M-Is) at the School of Medicine at Virginia Commonwealth University have been surveyed with a written questionnaire on their computer literacy. The survey's purpose is to learn the students' levels of knowledge, skill, and experience with computer technology to guide instructional services and facilities. Methodology: The questionnaire was administered during M-I orientation or mailed to students' homes after matriculation. It evolved from sixteen questions in 1991 to twenty-three questions in 2000, with fifteen questions common to all. Results: The average survey response rate was 81% from an average of 177 students. Six major changes were introduced based on information collected from the surveys and advances in technology: production of CD-ROMs distributed to students containing required computer-based instructional programs, delivery of evaluation instruments to students via the Internet, modification of the lab to a mostly PC-based environment, development of an electronic curriculum Website, development of computerized examinations for medical students to prepare them for the computerized national board examinations, and initiation of a personal digital assistant (PDA) project for students to evaluate PDAs' usefulness in clinical settings. Conclusion: The computer literacy survey provides a snapshot of students' past and present use of technology and guidance for the development of services and facilities. PMID:11999178

  2. Strategic initiatives to maintain pharmaceutical care and clinical pharmacists sufficiency in Saudi Arabia.

    PubMed

    Albekairy, Abdulkareem M; Khalidi, Nabil; Alkatheri, Abdulmalik M; Althiab, Khalifa; Alharbi, Shmeylan; Aldekhael, Saleh; Qandil, Amjad M; Alknawy, Bandar

    2015-01-01

    The shortage of clinical pharmacists in Saudi Arabia has limited the full implementation of pharmaceutical care in most of its hospitals. The National Guard Health Affairs hospitals. This work discussed the Department of Pharmaceutical Care, and the King Saud Bin Abdulaziz University for Health Sciences College of Pharmacy four initiatives that were planned in 2009-2010 to develop and recruit clinical pharmacists, practitioners, or faculty. The combined initiatives were aimed at (1) instituting a 4-year clinical skills development career ladder, (2) expanding the National Guard Health Affairs postgraduate residency program, (3) offering scholarships to qualified pharmacy graduates to pursue the PharmD degree and a PGY-1 residency training in the United States, and (4) recruiting non-Saudi clinical pharmacists educated and trained in the United States to ameliorate the current shortage of practitioner. The current number of clinical pharmacists practicing at the National Guard Health Affairs at central region is 24, most of whom are Board Certified by the American Pharmacists Association Board of Pharmacy Specialties. The four initiatives, based on current trends, suggest that 60-65 positions will be added by 2017-2018, barring attrition. Saudi Arabia and many developing countries will continue to experience a shortage in clinical pharmacists due to the high demand for clinical pharmacy services. A multifaceted approach is recommended to address the problem.

  3. Strategic initiatives to maintain pharmaceutical care and clinical pharmacists sufficiency in Saudi Arabia

    PubMed Central

    Khalidi, Nabil; Alkatheri, Abdulmalik M; Althiab, Khalifa; Alharbi, Shmeylan; Aldekhael, Saleh; Qandil, Amjad M; Alknawy, Bandar

    2015-01-01

    Objectives: The shortage of clinical pharmacists in Saudi Arabia has limited the full implementation of pharmaceutical care in most of its hospitals. The National Guard Health Affairs hospitals. This work discussed the Department of Pharmaceutical Care, and the King Saud Bin Abdulaziz University for Health Sciences College of Pharmacy four initiatives that were planned in 2009–2010 to develop and recruit clinical pharmacists, practitioners, or faculty. Methods: The combined initiatives were aimed at (1) instituting a 4-year clinical skills development career ladder, (2) expanding the National Guard Health Affairs postgraduate residency program, (3) offering scholarships to qualified pharmacy graduates to pursue the PharmD degree and a PGY-1 residency training in the United States, and (4) recruiting non-Saudi clinical pharmacists educated and trained in the United States to ameliorate the current shortage of practitioner. Results: The current number of clinical pharmacists practicing at the National Guard Health Affairs at central region is 24, most of whom are Board Certified by the American Pharmacists Association Board of Pharmacy Specialties. Conclusions: The four initiatives, based on current trends, suggest that 60–65 positions will be added by 2017–2018, barring attrition. Saudi Arabia and many developing countries will continue to experience a shortage in clinical pharmacists due to the high demand for clinical pharmacy services. A multifaceted approach is recommended to address the problem. PMID:26770792

  4. Mathematical models for the S. D. I. (Strategic Defense Initiative). Master's thesis

    SciTech Connect

    Ilan-Lipowsky, Y.

    1987-06-01

    SDI technologies may affect the concepts of weapons systems and reshape the battlefields of the future. In this research, few of the SDI systems were analyzed and modeled mathematically. The different models were gathered in a software package that may be run on a personal computer. The intention was to produce a handy tool for preliminary studies and designs. The following topics are covered: aerodynamic design of hypervelocity projectiles, flight simulation of hypervelocity projectiles, railgun simulation, ground track of orbits, guidance and homing. A few case studies were analyzed to suggest and demonstrate potential use of these models.

  5. Computer Simulation in Mass Emergency and Disaster Response: An Evaluation of Its Effectiveness as a Tool for Demonstrating Strategic Competency in Emergency Department Medical Responders

    ERIC Educational Resources Information Center

    O'Reilly, Daniel J.

    2011-01-01

    This study examined the capability of computer simulation as a tool for assessing the strategic competency of emergency department nurses as they responded to authentically computer simulated biohazard-exposed patient case studies. Thirty registered nurses from a large, urban hospital completed a series of computer-simulated case studies of…

  6. Computer Simulation in Mass Emergency and Disaster Response: An Evaluation of Its Effectiveness as a Tool for Demonstrating Strategic Competency in Emergency Department Medical Responders

    ERIC Educational Resources Information Center

    O'Reilly, Daniel J.

    2011-01-01

    This study examined the capability of computer simulation as a tool for assessing the strategic competency of emergency department nurses as they responded to authentically computer simulated biohazard-exposed patient case studies. Thirty registered nurses from a large, urban hospital completed a series of computer-simulated case studies of…

  7. Computer-assisted initial diagnosis of rare diseases

    PubMed Central

    Piñol, Marc; Vilaplana, Jordi; Teixidó, Ivan; Cruz, Joaquim; Comas, Jorge; Vilaprinyo, Ester; Sorribas, Albert

    2016-01-01

    Introduction. Most documented rare diseases have genetic origin. Because of their low individual frequency, an initial diagnosis based on phenotypic symptoms is not always easy, as practitioners might never have been exposed to patients suffering from the relevant disease. It is thus important to develop tools that facilitate symptom-based initial diagnosis of rare diseases by clinicians. In this work we aimed at developing a computational approach to aid in that initial diagnosis. We also aimed at implementing this approach in a user friendly web prototype. We call this tool Rare Disease Discovery. Finally, we also aimed at testing the performance of the prototype. Methods. Rare Disease Discovery uses the publicly available ORPHANET data set of association between rare diseases and their symptoms to automatically predict the most likely rare diseases based on a patient’s symptoms. We apply the method to retrospectively diagnose a cohort of 187 rare disease patients with confirmed diagnosis. Subsequently we test the precision, sensitivity, and global performance of the system under different scenarios by running large scale Monte Carlo simulations. All settings account for situations where absent and/or unrelated symptoms are considered in the diagnosis. Results. We find that this expert system has high diagnostic precision (≥80%) and sensitivity (≥99%), and is robust to both absent and unrelated symptoms. Discussion. The Rare Disease Discovery prediction engine appears to provide a fast and robust method for initial assisted differential diagnosis of rare diseases. We coupled this engine with a user-friendly web interface and it can be freely accessed at http://disease-discovery.udl.cat/. The code and most current database for the whole project can be downloaded from https://github.com/Wrrzag/DiseaseDiscovery/tree/no_classifiers. PMID:27547534

  8. Computer-assisted initial diagnosis of rare diseases.

    PubMed

    Alves, Rui; Piñol, Marc; Vilaplana, Jordi; Teixidó, Ivan; Cruz, Joaquim; Comas, Jorge; Vilaprinyo, Ester; Sorribas, Albert; Solsona, Francesc

    2016-01-01

    Introduction. Most documented rare diseases have genetic origin. Because of their low individual frequency, an initial diagnosis based on phenotypic symptoms is not always easy, as practitioners might never have been exposed to patients suffering from the relevant disease. It is thus important to develop tools that facilitate symptom-based initial diagnosis of rare diseases by clinicians. In this work we aimed at developing a computational approach to aid in that initial diagnosis. We also aimed at implementing this approach in a user friendly web prototype. We call this tool Rare Disease Discovery. Finally, we also aimed at testing the performance of the prototype. Methods. Rare Disease Discovery uses the publicly available ORPHANET data set of association between rare diseases and their symptoms to automatically predict the most likely rare diseases based on a patient's symptoms. We apply the method to retrospectively diagnose a cohort of 187 rare disease patients with confirmed diagnosis. Subsequently we test the precision, sensitivity, and global performance of the system under different scenarios by running large scale Monte Carlo simulations. All settings account for situations where absent and/or unrelated symptoms are considered in the diagnosis. Results. We find that this expert system has high diagnostic precision (≥80%) and sensitivity (≥99%), and is robust to both absent and unrelated symptoms. Discussion. The Rare Disease Discovery prediction engine appears to provide a fast and robust method for initial assisted differential diagnosis of rare diseases. We coupled this engine with a user-friendly web interface and it can be freely accessed at http://disease-discovery.udl.cat/. The code and most current database for the whole project can be downloaded from https://github.com/Wrrzag/DiseaseDiscovery/tree/no_classifiers.

  9. USER'S GUIDE: Strategic Waste Minimization Initiative (SWAMI) Version 2.0 - A Software Tool to Aid in Process Analysis for Pollution Prevention

    EPA Science Inventory

    The Strategic WAste Minimization Initiative (SWAMI) Software, Version 2.0 is a tool for using process analysis for identifying waste minimization opportunities within an industrial setting. The software requires user-supplied information for process definition, as well as materia...

  10. USER'S GUIDE: Strategic Waste Minimization Initiative (SWAMI) Version 2.0 - A Software Tool to Aid in Process Analysis for Pollution Prevention

    EPA Science Inventory

    The Strategic WAste Minimization Initiative (SWAMI) Software, Version 2.0 is a tool for using process analysis for identifying waste minimization opportunities within an industrial setting. The software requires user-supplied information for process definition, as well as materia...

  11. INTEGRATING COMPUTATIONAL PROTEIN FUNCTION PREDICTION INTO DRUG DISCOVERY INITIATIVES

    PubMed Central

    Grant, Marianne A.

    2014-01-01

    Pharmaceutical researchers must evaluate vast numbers of protein sequences and formulate innovative strategies for identifying valid targets and discovering leads against them as a way of accelerating drug discovery. The ever increasing number and diversity of novel protein sequences identified by genomic sequencing projects and the success of worldwide structural genomics initiatives have spurred great interest and impetus in the development of methods for accurate, computationally empowered protein function prediction and active site identification. Previously, in the absence of direct experimental evidence, homology-based protein function annotation remained the gold-standard for in silico analysis and prediction of protein function. However, with the continued exponential expansion of sequence databases, this approach is not always applicable, as fewer query protein sequences demonstrate significant homology to protein gene products of known function. As a result, several non-homology based methods for protein function prediction that are based on sequence features, structure, evolution, biochemical and genetic knowledge have emerged. Herein, we review current bioinformatic programs and approaches for protein function prediction/annotation and discuss their integration into drug discovery initiatives. The development of such methods to annotate protein functional sites and their application to large protein functional families is crucial to successfully utilizing the vast amounts of genomic sequence information available to drug discovery and development processes. PMID:25530654

  12. DOE Advanced Scientific Computing Advisory Committee (ASCAC) Report: Exascale Computing Initiative Review

    SciTech Connect

    Reed, Daniel; Berzins, Martin; Pennington, Robert; Sarkar, Vivek; Taylor, Valerie

    2015-08-01

    On November 19, 2014, the Advanced Scientific Computing Advisory Committee (ASCAC) was charged with reviewing the Department of Energy’s conceptual design for the Exascale Computing Initiative (ECI). In particular, this included assessing whether there are significant gaps in the ECI plan or areas that need to be given priority or extra management attention. Given the breadth and depth of previous reviews of the technical challenges inherent in exascale system design and deployment, the subcommittee focused its assessment on organizational and management issues, considering technical issues only as they informed organizational or management priorities and structures. This report presents the observations and recommendations of the subcommittee.

  13. 76 FR 35275 - Export Control Reform Initiative: Strategic Trade Authorization License Exception

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-16

    ...This rule adds a new license exception to the Export Administration Regulations (EAR) that authorizes the export, reexport, and transfer (in-country) of specified items to destinations that pose relatively low risk that those items will be used for a purpose that license requirements are designed to prevent. Use of the exception is conditioned upon the creation and exchange by the parties to the transaction of notifications and statements designed to provide assurance against diversion of such items to other destinations. The exception is only relevant to exports, reexports, and transfers for which a license is required under the EAR. Thus, if the EAR do not impose an obligation to apply for and receive a license before exporting, reexporting, or transferring an item subject to the EAR, STA is not relevant to the transaction. The exception does not alter any of the General Prohibitions in the EAR against unlicensed exports, reexports, or transfers to proscribed end users, end uses, or destinations. This rule, has been cleared by several departments, including Defense, State, Homeland Security, and Justice. This rule is part of the Administration's Export Control Reform Initiative, undertaken as a result of the fundamental review of the U.S. export control system that the President announced in August 2009.

  14. Developing a Comprehensive Strategic Plan for Campus Computing: A User-Friendly Approach.

    ERIC Educational Resources Information Center

    Burrill, Dwight A.; Copenhaver, Carol

    The Information Services Plan (ISP) developed at Howard Community College (HCC), in Columbia, Maryland, is designed to ensure that the necessary data, equipment, and communications technologies will be available to enable the college to meet its strategic goals. The plan provides for analyses of the current information services operating…

  15. The Vietnam Initiative on Zoonotic Infections (VIZIONS): A Strategic Approach to Studying Emerging Zoonotic Infectious Diseases.

    PubMed

    Rabaa, Maia A; Tue, Ngo Tri; Phuc, Tran My; Carrique-Mas, Juan; Saylors, Karen; Cotten, Matthew; Bryant, Juliet E; Nghia, Ho Dang Trung; Cuong, Nguyen Van; Pham, Hong Anh; Berto, Alessandra; Phat, Voong Vinh; Dung, Tran Thi Ngoc; Bao, Long Hoang; Hoa, Ngo Thi; Wertheim, Heiman; Nadjm, Behzad; Monagin, Corina; van Doorn, H Rogier; Rahman, Motiur; Tra, My Phan Vu; Campbell, James I; Boni, Maciej F; Tam, Pham Thi Thanh; van der Hoek, Lia; Simmonds, Peter; Rambaut, Andrew; Toan, Tran Khanh; Van Vinh Chau, Nguyen; Hien, Tran Tinh; Wolfe, Nathan; Farrar, Jeremy J; Thwaites, Guy; Kellam, Paul; Woolhouse, Mark E J; Baker, Stephen

    2015-12-01

    The effect of newly emerging or re-emerging infectious diseases of zoonotic origin in human populations can be potentially catastrophic, and large-scale investigations of such diseases are highly challenging. The monitoring of emergence events is subject to ascertainment bias, whether at the level of species discovery, emerging disease events, or disease outbreaks in human populations. Disease surveillance is generally performed post hoc, driven by a response to recent events and by the availability of detection and identification technologies. Additionally, the inventory of pathogens that exist in mammalian and other reservoirs is incomplete, and identifying those with the potential to cause disease in humans is rarely possible in advance. A major step in understanding the burden and diversity of zoonotic infections, the local behavioral and demographic risks of infection, and the risk of emergence of these pathogens in human populations is to establish surveillance networks in populations that maintain regular contact with diverse animal populations, and to simultaneously characterize pathogen diversity in human and animal populations. Vietnam has been an epicenter of disease emergence over the last decade, and practices at the human/animal interface may facilitate the likelihood of spillover of zoonotic pathogens into humans. To tackle the scientific issues surrounding the origins and emergence of zoonotic infections in Vietnam, we have established The Vietnam Initiative on Zoonotic Infections (VIZIONS). This countrywide project, in which several international institutions collaborate with Vietnamese organizations, is combining clinical data, epidemiology, high-throughput sequencing, and social sciences to address relevant one-health questions. Here, we describe the primary aims of the project, the infrastructure established to address our scientific questions, and the current status of the project. Our principal objective is to develop an integrated approach to

  16. Strategic research in the social sciences

    SciTech Connect

    Bainbridge, W.S.

    1995-12-31

    The federal government has identified a number of multi-agency funding initiatives for science in strategic areas, such as the initiatives on global environmental change and high performance computing, that give some role to the social sciences. Seven strategic areas for social science research are given with potential for federal funding: (1) Democratization. (2) Human Capital. (3) Administrative Science. (4) Cognitive Science. (5) High Performance Computing and Digital Libraries. (6) Human Dimensions of Environmental Change. and (7) Human Genetic Diversity. The first two are addressed in detail and the remainder as a group. 10 refs.

  17. Reporting on Strategic Considerations About the Role of Science in Initial Human Missions to Mars

    NASA Astrophysics Data System (ADS)

    Beaty, David; Bass, Deborah; Thronson, Harley; Hays, Lindsay; Carberry, Chris; Cassady, Joe; Craig, Mark; Duggan, Matt; Drake, Bret; Stern, Jennifer; Zucker, Rick

    2016-07-01

    mission prior to a Mars surface mission should be initiated. 3. A well-planned set of science objectives for a future human-landed mission to Mars is essential in order to sustain coordination among the science and human spaceflight communities. In particular, while it is clear how humans on the surface of Mars would significantly accelerate the pace of the search for past life, it is unclear how humans would play a role in (and not serve as a hindrance to) the search for extant life. Further study should be supported. 4. Sustained formal collaboration among Mars scientists, engineers, technologists, and teams developing scenarios for Mars exploration should be supported. The human and robotic sides of the Mars exploration community need to become further engaged with each other, particularly as we enter a potential period of dual-purpose (science + human precursor) missions. Central to this era is generating mutual support for a Mars sample return architecture as a goal that has crucial value to both the human preparatory program and planetary science.

  18. Strategic forces

    SciTech Connect

    Not Available

    1990-10-01

    The Air Force now plans to retain the Minuteman II and III missile force through fiscal year 2008. Introduced about 25 years ago, these missiles have served as a nuclear deterrence for longer than initially envisioned. Over the extended lives of the systems, questions have arisen over their continued reliability and operational effectiveness, particularly the Minuteman II system. Limited flight testing, due to a shortage of test missiles, and reduced reliability caused by age-related deterioration of guidance computers and propulsion motors are two factors undermining confidence in the Minuteman II. GAO believes that the Minuteman II could be retired before 1998 as presently contemplated under an assumption of a Strategic Arms Reduction Talks agreement. An alternative would be to reinstate the Air Force's plans to replace deteriorated missile components and acquire the assets needed to resume flight testing at rates necessary to restore and sustain confidence in the system's performance through fiscal year 2008. However, on the basis of current test schedules, GAO is concerned that components to test the missile's warheads will be depleted by about 1999.

  19. Strategic priming with multiple antigens can yield memory cell phenotypes optimized for infection with Mycobacterium tuberculosis: A computational study

    DOE PAGES

    Ziraldo, Cordelia; Gong, Chang; Kirschner, Denise E.; ...

    2016-01-06

    Lack of an effective vaccine results in 9 million new cases of tuberculosis (TB) every year and 1.8 million deaths worldwide. While many infants are vaccinated at birth with BCG (an attenuated M. bovis), this does not prevent infection or development of TB after childhood. Immune responses necessary for prevention of infection or disease are still unknown, making development of effective vaccines against TB challenging. Several new vaccines are ready for human clinical trials, but these trials are difficult and expensive; especially challenging is determining the appropriate cellular response necessary for protection. The magnitude of an immune response is likelymore » key to generating a successful vaccine. Characteristics such as numbers of central memory (CM) and effector memory (EM) T cells responsive to a diverse set of epitopes are also correlated with protection. Promising vaccines against TB contain mycobacterial subunit antigens (Ag) present during both active and latent infection. We hypothesize that protection against different key immunodominant antigens could require a vaccine that produces different levels of EM and CM for each Ag-specific memory population. We created a computational model to explore EM and CM values, and their ratio, within what we term Memory Design Space. Our model captures events involved in T cell priming within lymph nodes and tracks their circulation through blood to peripheral tissues. We used the model to test whether multiple Ag-specific memory cell populations could be generated with distinct locations within Memory Design Space at a specific time point post vaccination. Boosting can further shift memory populations to memory cell ratios unreachable by initial priming events. By strategically varying antigen load, properties of cellular interactions within the LN, and delivery parameters (e.g., number of boosts) of multi-subunit vaccines, we can generate multiple Ag-specific memory populations that cover a wide range of

  20. Strategic Priming with Multiple Antigens can Yield Memory Cell Phenotypes Optimized for Infection with Mycobacterium tuberculosis: A Computational Study

    PubMed Central

    Ziraldo, Cordelia; Gong, Chang; Kirschner, Denise E.; Linderman, Jennifer J.

    2016-01-01

    Lack of an effective vaccine results in 9 million new cases of tuberculosis (TB) every year and 1.8 million deaths worldwide. Although many infants are vaccinated at birth with BCG (an attenuated M. bovis), this does not prevent infection or development of TB after childhood. Immune responses necessary for prevention of infection or disease are still unknown, making development of effective vaccines against TB challenging. Several new vaccines are ready for human clinical trials, but these trials are difficult and expensive; especially challenging is determining the appropriate cellular response necessary for protection. The magnitude of an immune response is likely key to generating a successful vaccine. Characteristics such as numbers of central memory (CM) and effector memory (EM) T cells responsive to a diverse set of epitopes are also correlated with protection. Promising vaccines against TB contain mycobacterial subunit antigens (Ag) present during both active and latent infection. We hypothesize that protection against different key immunodominant antigens could require a vaccine that produces different levels of EM and CM for each Ag-specific memory population. We created a computational model to explore EM and CM values, and their ratio, within what we term Memory Design Space. Our model captures events involved in T cell priming within lymph nodes and tracks their circulation through blood to peripheral tissues. We used the model to test whether multiple Ag-specific memory cell populations could be generated with distinct locations within Memory Design Space at a specific time point post vaccination. Boosting can further shift memory populations to memory cell ratios unreachable by initial priming events. By strategically varying antigen load, properties of cellular interactions within the LN, and delivery parameters (e.g., number of boosts) of multi-subunit vaccines, we can generate multiple Ag-specific memory populations that cover a wide range of

  1. Systems 2020: Strategic Initiative

    DTIC Science & Technology

    2010-08-29

    ORGANIZATION NAME(S) AND ADDRESS(ES) Stevens Institute of Technology,Systems Engineering Research Center (SERC),1 Castle Point on Hudson ,Hoboken,NJ...Engineering (PBE) .......................................................................................... 15 2.1.5 Capability on Demand (COD...45 2.4 Capability on Demand (COD) Analysis ........................................................................................... 46 2.4.1

  2. Cultivating strategic thinking skills.

    PubMed

    Shirey, Maria R

    2012-06-01

    This department highlights change management strategies that may be successful in strategically planning and executing organizational change initiatives. With the goal of presenting practical approaches helpful to nurse leaders advancing organizational change, content includes evidence-based projects, tools, and resources that mobilize and sustain organizational change initiatives. In this article, the author presents an overview of strategic leadership and offers approaches for cultivating strategic thinking skills.

  3. Assured Access/Mobile Computing Initiatives on Five University Campuses.

    ERIC Educational Resources Information Center

    Blurton, Craig; Chee, Yam San; Long, Phillip D.; Resmer, Mark; Runde, Craig

    Mobile computing and assured access are becoming popular terms to describe a growing number of university programs which take advantage of ubiquitous network access points and the portability of notebook computers to ensure all students have access to digital tools and resources. However, the implementation of such programs varies widely from…

  4. Thrust and parry of the SIOP (single integrated operational plan) and sdi (strategic defense initiative). Research report

    SciTech Connect

    Zank, G.D.

    1989-05-01

    The relationship between strategic offensive capabilities (reflected in the SIOP) and emerging strategic defensive capabilities (reflected by SDI) is not being adequately addressed. A summary of the existing nuclear war planning process is provided, and an analagous defensive process is postulated. Parallels and differences between the two processes are discussed. Potential areas for information exchange and cooperation are identified to enhance deterrence and improve war fighting potential. Operational, technical and political issues requiring resolution are raised and recommendations to resolve these issues are made.

  5. Computational modeling and analysis of insulin induced eukaryotic translation initiation.

    PubMed

    Lequieu, Joshua; Chakrabarti, Anirikh; Nayak, Satyaprakash; Varner, Jeffrey D

    2011-11-01

    Insulin, the primary hormone regulating the level of glucose in the bloodstream, modulates a variety of cellular and enzymatic processes in normal and diseased cells. Insulin signals are processed by a complex network of biochemical interactions which ultimately induce gene expression programs or other processes such as translation initiation. Surprisingly, despite the wealth of literature on insulin signaling, the relative importance of the components linking insulin with translation initiation remains unclear. We addressed this question by developing and interrogating a family of mathematical models of insulin induced translation initiation. The insulin network was modeled using mass-action kinetics within an ordinary differential equation (ODE) framework. A family of model parameters was estimated, starting from an initial best fit parameter set, using 24 experimental data sets taken from literature. The residual between model simulations and each of the experimental constraints were simultaneously minimized using multiobjective optimization. Interrogation of the model population, using sensitivity and robustness analysis, identified an insulin-dependent switch that controlled translation initiation. Our analysis suggested that without insulin, a balance between the pro-initiation activity of the GTP-binding protein Rheb and anti-initiation activity of PTEN controlled basal initiation. On the other hand, in the presence of insulin a combination of PI3K and Rheb activity controlled inducible initiation, where PI3K was only critical in the presence of insulin. Other well known regulatory mechanisms governing insulin action, for example IRS-1 negative feedback, modulated the relative importance of PI3K and Rheb but did not fundamentally change the signal flow.

  6. New Toxico-Cheminformatics & Computational Toxicology Initiatives At EPA

    EPA Science Inventory

    EPA’s National Center for Computational Toxicology is building capabilities to support a new paradigm for toxicity screening and prediction. The DSSTox project is improving public access to quality structure-annotated chemical toxicity information in less summarized forms than tr...

  7. New Toxico-Cheminformatics & Computational Toxicology Initiatives At EPA

    EPA Science Inventory

    EPA’s National Center for Computational Toxicology is building capabilities to support a new paradigm for toxicity screening and prediction. The DSSTox project is improving public access to quality structure-annotated chemical toxicity information in less summarized forms than tr...

  8. Computing Binary Black Hole Initial Data in Damped Harmonic Gauge

    NASA Astrophysics Data System (ADS)

    Varma, Vijay; Scheel, Mark; SXS Collaboration

    2017-01-01

    Binary black hole evolution in the Spectral Einstein Code (SpEC) is currently done in the damped harmonic (DH) gauge, which has proven very useful for merger simulations. However, the initial data for the simulation is constructed in a different gauge. Once the evolution starts we need to perform a smooth gauge transformation to the DH gauge, introducing additional gauge dynamics into the evolution. In this work, we construct the initial data in the DH gauge itself, which allows us to avoid the above gauge transformation. This can have added benefits such as possibly reducing junk radiation, making it easier to achieve a desired orbital eccentricity, reducing the runtime of simulations, and being able to start evolution closer to the merger.

  9. Computing Binary Black Hole Initial Data in Damped Harmonic Gauge

    NASA Astrophysics Data System (ADS)

    Varma, Vijay; Scheel, Mark; Simulating Extreme Spacetimes Collaboration

    2016-03-01

    Binary black hole evolution in the Spectral Einstein Code (SpEC) is currently done in the damped harmonic (DH) gauge, which has proven very useful for merger simulations. However, the initial data for the simulation is constructed in a different gauge. Once the evolution starts we need to perform a smooth gauge transformation to the DH gauge, introducing additional gauge dynamics into the evolution. In this work, we construct the initial data in the DH gauge itself, which allows us to avoid the above gauge transformation. This can have added benefits such as possibly reducing junk radiation, making it easier to achieve a desired orbital eccentricity, reducing the runtime of simulations, and being able to start evolution closer to the merger.

  10. Notification: Fieldwork for CIGIE Cloud Computing Initiative – Status of Cloud-Computing Within the Federal Government

    EPA Pesticide Factsheets

    Project #OA-FY14-0126, January 15, 2014. The EPA OIG is starting fieldwork on the Council of the Inspectors General on Integrity and Efficiency (CIGIE) Cloud Computing Initiative – Status of Cloud-Computing Environments Within the Federal Government.

  11. A comprehensive computing initiative for MFE. Revision 1

    SciTech Connect

    Cohen, R.H.; Crotinger, J.A.; Baldwin, D.E.

    1996-03-11

    The authors propose that a national initiative by launched to develop a comprehensive simulation facility for MFE. The facility would consist of physics codes developed by the national MFE community tightly but flexibly coupled through a programmable shell, enabling effectively simultaneous solution of the models in the various codes. The world ``facility`` is chosen to convey the notion that this is where one would go to conduct numerical experiments, using a full set of modules to describe an entire device, a coupled subset to describe particular aspects of a device, or a combination of the facility`s modules plus the user`s own physics.

  12. Teaching Strategic Text Review by Computer and Interaction with Student Characteristics.

    ERIC Educational Resources Information Center

    Tobias, Sigmund

    1988-01-01

    Discussion of reading strategies focuses on a study of high school students that used three presentation modes via computer, with and without explanations about the value of text review. Highlights include pretests and posttests, student characteristics, test anxiety, prior knowledge, and implications for aptitude treatment interaction research…

  13. Initial results of finger imaging using photoacoustic computed tomography

    NASA Astrophysics Data System (ADS)

    van Es, Peter; Biswas, Samir K.; Moens, Hein J. Bernelot; Steenbergen, Wiendelt; Manohar, Srirang

    2014-06-01

    We present a photoacoustic computed tomography investigation on a healthy human finger, to image blood vessels with a focus on vascularity across the interphalangeal joints. The cross-sectional images were acquired using an imager specifically developed for this purpose. The images show rich detail of the digital blood vessels with diameters between 100 μm and 1.5 mm in various orientations and at various depths. Different vascular layers in the skin including the subpapillary plexus could also be visualized. Acoustic reflections on the finger bone of photoacoustic signals from skin were visible in sequential slice images along the finger except at the location of the joint gaps. Not unexpectedly, the healthy synovial membrane at the joint gaps was not detected due to its small size and normal vascularization. Future research will concentrate on studying digits afflicted with rheumatoid arthritis to detect the inflamed synovium with its heightened vascularization, whose characteristics are potential markers for disease activity.

  14. SAGEN (SADMT (Strategic Defense Initiative Architecture Dataflow Modeling Technique) Generator) User’s Guide Version. 1.5.

    DTIC Science & Technology

    1988-04-01

    L0425 P.O. Box 179 Denver, CO 80201 Larry L. Lehman Integrated Systems Inc. 2500 Mission College Road Santa Clara, CA 95054 Eric Leighninger Dynamics...Minister Blvd. ." , Seal Beach, CA 90740-7644 Larry Tubbs % US Army Strategic Defense Command DASH-H-5B - 106 Wynn Dr. Huntsville, AL 35807 -11 pp...Communication Systems P.O. Box 1260 Denver, CO 80201-1260 CSED Review Panel Dr. Dan Alpert , Director 1 copy ,- Center for Advanced Study University of

  15. Photon counting computed tomography: concept and initial results.

    PubMed

    Shikhaliev, Polad M; Xu, Tong; Molloi, Sabee

    2005-02-01

    A concept of a photon counting cone beam CT is proposed. The system uses a new Multi Slit Multi Slice (MSMS) cone beam acquisition geometry utilizing a linear array photon counting detectors. The MSMS cone beam acquisition is a direct analogy of the scanning multislit acquisition used in projection x-ray imaging. This geometry provides a CT imaging with dose efficient scatter rejection and allows for using available photon counting detectors. The microchannel plate (MCP) detector is proposed as a linear array photon counting detector for MSMS cone beam CT system. Initial testing of the MCP detector for CT application was performed. The field of view of the prototype MCP detector is 60 mm. A delay line position encoding electronics was used. The electronics has a single channel input for evaluation of events from the entire detector field of view. This limits the system count rate at 2 x 10(5) count/s. The spatial resolution of this detector is 80 microm FWHM at 40 kVp and 200 microm FWHM at 90 kVp tube voltages. The detector noise in CT projections is less than 1 count/pixel for the 80 microm pixel size. The CT projections contain quantum-limited and scatter free signal. Images of a contrast phantom and a small animal were acquired at 50 kVp and 80 kVp tube voltages. The CT numbers for different contrast elements were calculated for a given x-ray spectrum and compared with experimental values. The quantum efficiency of the current detector is 56% at 90 kVp, which is suboptimal because of the large channel diameter (25 microm) of these MCPs. The MCPs with smaller channels and higher efficiencies are being tested. The quantum efficiency was measured to be 70% for a new MCP with 5 microm channel diameter. Design parameters of a clinically applicable photon counting MSMS cone beam CT for breast imaging was evaluated. System uses 20 cm field of view MCP detectors based on 5 microm channel MCPs and high count rate ASIC electronics. It was concluded that the MSMS cone

  16. Thinking strategically.

    PubMed

    Goree, Michael

    2002-01-01

    Over the course of the past 20 years, human resources has tried a variety of strategic initiatives to add value to the working environment, from the alphabets of TQM, CQI, EVA, ROI, ISO, QS, Theory X, Y, Z, Generation X and Y to re-engineering, balanced scorecard, lean, hoshin, six sigma, to Margaret Wheatley's "The Simpler Way" and finally to cheese and fish. The problem is that none of these is a strategy. They are all tactics to accomplish or achieve a strategy.

  17. USACE Navigation Strategic Vision

    DTIC Science & Technology

    2012-12-01

    Initiatives ( SNI ) within these Objectives. Figure 2 illustrates the relationship of SNI to the focus areas and guiding documents, the USACE Campaign...appreciation of the value provided by the MTS and proactive participation with the USACE navigation program. Figure 2. Strategic Navigation Initiatives ( SNI ...Campaign Plan Goal 5, Objective 4a, the CW Strategic Plan Goal 5, and NSV Objective 4 and two supporting SNIs .   7 Objective: Create an inventory of all

  18. Common Challenges and Experiences of School Districts That Are Implementing One-to-One Computing Initiatives

    ERIC Educational Resources Information Center

    Topper, Andrew; Lancaster, Sean

    2013-01-01

    This article explores the implementation of various K-12 one-to-one computing initiatives to determine if patterns exist. These initiatives are funded in times of limited resources and constitute a serious investment in technology for the schools and districts adopting them. The goals of this study were to understand how and why one-to-one…

  19. Investigation of expert systems usage for software requirements development in the Strategic Defense Initiative environment. Interim report, May-July 1985

    SciTech Connect

    Chien; Liebowitz

    1986-06-10

    The Strategic Defense Initiative (SDI) poses a significant challenge to the United States, namely how to counter the threat of Soviet nuclear ballistic missiles. Part of the solution to this problem involves the development of sophisticated automatic programming techniques. Embedded within these techniques is how to develop and check the consistency of evolving SDI-related software requirements. This report addresses what has been done in developing tools for software requirements determination and what has to be done in developing future software requirements tools for the SDI environment. The use of expert systems in an inherent part of these considerations. This report first develops a basic foundation on software design. Specifically, its definition, emergence, description, and methodologies and tools are addressed. Afterwards, the SDI environment and its associated problems are described. Then, recommendations for a knowledge-based software requirements development approach are explained.

  20. Strategic Leadership for Education Reform: Lessons from the Statewide Systemic Initiatives Program. CPRE Policy Briefs RB-41

    ERIC Educational Resources Information Center

    Heck, Daniel J.; Weiss, Iris R.

    2005-01-01

    In 1990, the National Science Foundation (NSF) created the Statewide Systemic Initiative Program. The solicitation issued by the Directorate for Science and Engineering Education sought proposals "for projects intended to broaden the impact, accelerate the pace, and increase the effectiveness of improvements in science, mathematics, and…

  1. Strategic Technology

    DTIC Science & Technology

    2012-03-11

    of massive multi-player gaming environments to facilitate expert education, collaboration, and experimentation. Finally, it recommends a focus on red ... team analysis and experimentation as a means of minimizing strategic surprise from technological sources. To fully explore potential strategic

  2. Initialization and Restart in Stochastic Local Search: Computing a Most Probable Explanation in Bayesian Networks

    NASA Technical Reports Server (NTRS)

    Mengshoel, Ole J.; Wilkins, David C.; Roth, Dan

    2010-01-01

    For hard computational problems, stochastic local search has proven to be a competitive approach to finding optimal or approximately optimal problem solutions. Two key research questions for stochastic local search algorithms are: Which algorithms are effective for initialization? When should the search process be restarted? In the present work we investigate these research questions in the context of approximate computation of most probable explanations (MPEs) in Bayesian networks (BNs). We introduce a novel approach, based on the Viterbi algorithm, to explanation initialization in BNs. While the Viterbi algorithm works on sequences and trees, our approach works on BNs with arbitrary topologies. We also give a novel formalization of stochastic local search, with focus on initialization and restart, using probability theory and mixture models. Experimentally, we apply our methods to the problem of MPE computation, using a stochastic local search algorithm known as Stochastic Greedy Search. By carefully optimizing both initialization and restart, we reduce the MPE search time for application BNs by several orders of magnitude compared to using uniform at random initialization without restart. On several BNs from applications, the performance of Stochastic Greedy Search is competitive with clique tree clustering, a state-of-the-art exact algorithm used for MPE computation in BNs.

  3. Thinking Strategically.

    ERIC Educational Resources Information Center

    Jeffress, Conway

    2000-01-01

    Asserts that community college leaders must think strategically and understand the difference between what is important and immediate, and what is strategic and essential to the long-term survival of a college. States that thinking strategically aligns decision-making and actions with the core purpose of the college; produces core competencies in…

  4. The Thoratec mobile computer: initial in-hospital and outpatient experience.

    PubMed

    Sobieski, Michael A; George, Terri A; Slaughter, Mark S

    2004-01-01

    The purpose of this study was to test the operational effectiveness of the Thoratec mobile computer for monitoring and adjusting the portable TLC-II pneumatic driver. The TLC-II portable driver is approved by the Food and Drug Administration for use with either the paracorporeal ventricular assist device (VAD) or the Implantable Thoratec VAD. Currently, data log/file retrieval, changing device parameters, and initial VAD set-up is done with the cart mounted docking station. Thoratec has developed a tablet computer to perform the same tasks. The tablet computer weighs 3.2 lbs and has a 10.4 inch display. The mobile computer was evaluated in the clinic and multiple hospital settings as a mobile substitute for the docking station. For 120 consecutive days, the tablet computer was used exclusively for data file retrieval, changing device parameters, and initial VAD set up of the TLC-II portable drivers. Five patients, four paracorporeal VAD and one Implantable Thoratec VAD, using eight TLC-II portable drivers were evaluated. All patients were discharged home and followed as outpatients. The tablet computer was used by the VAD coordinator, two nurse clinicians, a perfusionist, and a research assistant. A total of 59 individual uses were performed (data retrieval, 46; parameter changes, 5; initial VAD set up, 8). Data were successfully obtained in all cases. Documentation of programmed settings and driver operation was achieved without difficulty.

  5. Large-Scale 1:1 Computing Initiatives: An Open Access Database

    ERIC Educational Resources Information Center

    Richardson, Jayson W.; McLeod, Scott; Flora, Kevin; Sauers, Nick J.; Kannan, Sathiamoorthy; Sincar, Mehmet

    2013-01-01

    This article details the spread and scope of large-scale 1:1 computing initiatives around the world. What follows is a review of the existing literature around 1:1 programs followed by a description of the large-scale 1:1 database. Main findings include: 1) the XO and the Classmate PC dominate large-scale 1:1 initiatives; 2) if professional…

  6. ONT High Gain Initiative WRAP (Wide Area Rapid Acoustic Prediction) computational performance section

    SciTech Connect

    McGraw, J.R.; Hedstrom, G.; De Groot, T.

    1990-10-02

    LLNL received a contract during March 1990 to perform three tasks for ONT. This letter report covers Task I which concerned a supercomputing effort in a program termed the High Gain Initiative, which is an anti-submarine (ASW) project that requires substantial computational and signal processing expertise. The core of the computational aspects at the present time is a code called WRAP (Wide Area Rapid Acoustic Prediction). LLNL's objective was to study the WRAP model and determine the feasibility and limits of its optimization. At the present time, the WRAP code runs on a single processor VAX computer.

  7. Quantum computers and unstructured search: finding and counting items with an arbitrarily entangled initial state

    NASA Astrophysics Data System (ADS)

    Carlini, A.; Hosoya, A.

    2001-02-01

    Grover's quantum algorithm for an unstructured search problem and the COUNT algorithm by Brassard et al. are generalized to the case when the initial state is arbitrarily and maximally entangled. This ansatz might be relevant with quantum subroutines, when the computational qubits and the environment are coupled, and in general when the control over the quantum system is partial.

  8. Examining Response to a One-to-One Computer Initiative: Student and Teacher Voices

    ERIC Educational Resources Information Center

    Storz, Mark G.; Hoffman, Amy R.

    2013-01-01

    The impact of a one-to-one computing initiative at a Midwestern urban middle school was examined through phenomenological research techniques focusing on the voices of eighth grade students and their teachers. Analysis of transcripts from pre and post-implementation interviews of 47 students and eight teachers yielded patterns of responses to…

  9. An initial investigation into methods of computing transonic aerodynamic sensitivity coefficients

    NASA Technical Reports Server (NTRS)

    Carlson, Leland A.

    1988-01-01

    The initial effort was concentrated on developing the quasi-analytical approach for two-dimensional transonic flow. To keep the problem computationally efficient and straightforward, only the two-dimensional flow was considered and the problem was modeled using the transonic small perturbation equation.

  10. Meeting the needs of a community: teaching evidence-based youth violence prevention initiatives to members of strategic communities.

    PubMed

    Ruffolo, Daria C; Andresen, Pamela A; Winn, Keith L

    2013-01-01

    Youth violence is among the most serious health threats in the nation today. Violence disproportionately affects young people and people of color. Although the national rates of violent injury and homicide have shown a decline in most regions of the United States over the past 15 years, the rates of violence and related injuries among youth remain unacceptably high. The prevention of youth violence has been a priority of health departments nationwide, including the Cook County Department of Public Health. The goal of this project was to provide key community leaders, social service workers, and nurses within suburban Cook County with educational sessions on Blueprints for Violence Prevention, an initiative to promote evidence-based youth violence prevention programs.

  11. 45 CFR 233.34 - Computing the assistance payment in the initial one or two months (AFDC).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Computing the assistance payment in the initial one or two months (AFDC). 233.34 Section 233.34 Public Welfare Regulations Relating to Public Welfare... § 233.34 Computing the assistance payment in the initial one or two months (AFDC). A State shall compute...

  12. Determination of an Initial Mesh Density for Finite Element Computations via Data Mining

    SciTech Connect

    Kanapady, R; Bathina, S K; Tamma, K K; Kamath, C; Kumar, V

    2001-07-23

    Numerical analysis software packages which employ a coarse first mesh or an inadequate initial mesh need to undergo a cumbersome and time consuming mesh refinement studies to obtain solutions with acceptable accuracy. Hence, it is critical for numerical methods such as finite element analysis to be able to determine a good initial mesh density for the subsequent finite element computations or as an input to a subsequent adaptive mesh generator. This paper explores the use of data mining techniques for obtaining an initial approximate finite element density that avoids significant trial and error to start finite element computations. As an illustration of proof of concept, a square plate which is simply supported at its edges and is subjected to a concentrated load is employed for the test case. Although simplistic, the present study provides insight into addressing the above considerations.

  13. Geocomputation over Hybrid Computer Architecture and Systems: Prior Works and On-going Initiatives at UARK

    NASA Astrophysics Data System (ADS)

    Shi, X.

    2015-12-01

    As NSF indicated - "Theory and experimentation have for centuries been regarded as two fundamental pillars of science. It is now widely recognized that computational and data-enabled science forms a critical third pillar." Geocomputation is the third pillar of GIScience and geosciences. With the exponential growth of geodata, the challenge of scalable and high performance computing for big data analytics become urgent because many research activities are constrained by the inability of software or tool that even could not complete the computation process. Heterogeneous geodata integration and analytics obviously magnify the complexity and operational time frame. Many large-scale geospatial problems may be not processable at all if the computer system does not have sufficient memory or computational power. Emerging computer architectures, such as Intel's Many Integrated Core (MIC) Architecture and Graphics Processing Unit (GPU), and advanced computing technologies provide promising solutions to employ massive parallelism and hardware resources to achieve scalability and high performance for data intensive computing over large spatiotemporal and social media data. Exploring novel algorithms and deploying the solutions in massively parallel computing environment to achieve the capability for scalable data processing and analytics over large-scale, complex, and heterogeneous geodata with consistent quality and high-performance has been the central theme of our research team in the Department of Geosciences at the University of Arkansas (UARK). New multi-core architectures combined with application accelerators hold the promise to achieve scalability and high performance by exploiting task and data levels of parallelism that are not supported by the conventional computing systems. Such a parallel or distributed computing environment is particularly suitable for large-scale geocomputation over big data as proved by our prior works, while the potential of such advanced

  14. Field-Programmable Gate Array Computer in Structural Analysis: An Initial Exploration

    NASA Technical Reports Server (NTRS)

    Singleterry, Robert C., Jr.; Sobieszczanski-Sobieski, Jaroslaw; Brown, Samuel

    2002-01-01

    This paper reports on an initial assessment of using a Field-Programmable Gate Array (FPGA) computational device as a new tool for solving structural mechanics problems. A FPGA is an assemblage of binary gates arranged in logical blocks that are interconnected via software in a manner dependent on the algorithm being implemented and can be reprogrammed thousands of times per second. In effect, this creates a computer specialized for the problem that automatically exploits all the potential for parallel computing intrinsic in an algorithm. This inherent parallelism is the most important feature of the FPGA computational environment. It is therefore important that if a problem offers a choice of different solution algorithms, an algorithm of a higher degree of inherent parallelism should be selected. It is found that in structural analysis, an 'analog computer' style of programming, which solves problems by direct simulation of the terms in the governing differential equations, yields a more favorable solution algorithm than current solution methods. This style of programming is facilitated by a 'drag-and-drop' graphic programming language that is supplied with the particular type of FPGA computer reported in this paper. Simple examples in structural dynamics and statics illustrate the solution approach used. The FPGA system also allows linear scalability in computing capability. As the problem grows, the number of FPGA chips can be increased with no loss of computing efficiency due to data flow or algorithmic latency that occurs when a single problem is distributed among many conventional processors that operate in parallel. This initial assessment finds the FPGA hardware and software to be in their infancy in regard to the user conveniences; however, they have enormous potential for shrinking the elapsed time of structural analysis solutions if programmed with algorithms that exhibit inherent parallelism and linear scalability. This potential warrants further

  15. Geomagnetic model investigations for 1980 - 1989: A model for strategic defense initiative particle beam experiments and a study in the effects of data types and observatory bias solutions

    NASA Technical Reports Server (NTRS)

    Langel, Robert A.; Sabaka, T. J.; Baldwin, R. T.

    1991-01-01

    Two suites of geomagnetic field models were generated at the request of Los Alamos National Lab. concerning Strategic Defense Initiative (SDI) research. The first is a progression of five models incorporating MAGSAT data and data from a sequence of batches as a priori information. The batch sequence is: post 1979.5 observatory data, post 1980 land survey and selected aeromagnetic and marine survey data, a special White Sands (NM) area survey by Project Magnet with some additional post 1980 marine survey data, and finally DE-2 satellite data. These models are of 13th deg and order in their main field terms, and deg and order 10 in their first derivative temporal terms. The second suite consists of four models based solely upon post 1983.5 observatory and survey data. They are of deg and order 10 in main field and 8 in a first deg Taylor series. A comprehensive error analysis was applied to both series, which accounted for error sources such as the truncated core and crustal fields, and the neglected Sq and low deg crustal fields. Comparison of the power spectrum of the MGST (10/81) model with those of this series show good agreement.

  16. Super-resolution of multi-pixel and sub-pixel images for the SDI. Final report. [SDI (Strategic Defense Initiative)

    SciTech Connect

    Not Available

    1993-06-08

    The recent profound shift in the global balance of power in favor of the United States of America has had major repercussions on Strategic Defense Initiative (SDI) planning. In particular, the focus has shifted from the provision of protection for the United States against a massive raid, involving possibly thousands of reentry vehicles, to defense against a much more limited attack which could now, however, be launched from any part of the world. Additionally, the United States is seeking to protect its forces and allies overseas, and in the task of missile detection and tracking, allowance must now be made for trajectories which can begin and end in almost any inhabited area of the globe. Thus SDI demands on surveillance technology have been significantly expanded. Space-based imaging systems will play a vital role in the surveillance task. In this report a description is first given of a typical scenario. The potential imaging problems are then examined, the mathematical background is discussed, and the innovative algorithms which have been developed for correcting and enhancing the performance of the imaging sensor are described.

  17. Improving Royal Australian Air Force Strategic Airlift Planning by Application of a Computer Based Management Information System

    DTIC Science & Technology

    1991-12-01

    perceived ability of system to support organisational goals and objectives. Other: With what other informtion systems should commaications be considered... informtion system ? A system is not required or justified. Potential exists for a system but not right now. A system may be justified. However, the envirornet...IMPROVING ROYAL AUSTRALIAN AIR FORCE STRATEGIC AIRLIFT PLANNING BY APPLICATION OF A (XM E BASED MANAGEEN INFORMATION SYSTEM THESIS Neil A. Cooper Squadron

  18. Strategic priming with multiple antigens can yield memory cell phenotypes optimized for infection with Mycobacterium tuberculosis: A computational study

    SciTech Connect

    Ziraldo, Cordelia; Gong, Chang; Kirschner, Denise E.; Linderman, Jennifer J.

    2016-01-06

    Lack of an effective vaccine results in 9 million new cases of tuberculosis (TB) every year and 1.8 million deaths worldwide. While many infants are vaccinated at birth with BCG (an attenuated M. bovis), this does not prevent infection or development of TB after childhood. Immune responses necessary for prevention of infection or disease are still unknown, making development of effective vaccines against TB challenging. Several new vaccines are ready for human clinical trials, but these trials are difficult and expensive; especially challenging is determining the appropriate cellular response necessary for protection. The magnitude of an immune response is likely key to generating a successful vaccine. Characteristics such as numbers of central memory (CM) and effector memory (EM) T cells responsive to a diverse set of epitopes are also correlated with protection. Promising vaccines against TB contain mycobacterial subunit antigens (Ag) present during both active and latent infection. We hypothesize that protection against different key immunodominant antigens could require a vaccine that produces different levels of EM and CM for each Ag-specific memory population. We created a computational model to explore EM and CM values, and their ratio, within what we term Memory Design Space. Our model captures events involved in T cell priming within lymph nodes and tracks their circulation through blood to peripheral tissues. We used the model to test whether multiple Ag-specific memory cell populations could be generated with distinct locations within Memory Design Space at a specific time point post vaccination. Boosting can further shift memory populations to memory cell ratios unreachable by initial priming events. By strategically varying antigen load, properties of cellular interactions within the LN, and delivery parameters (e.g., number of boosts) of multi-subunit vaccines, we can generate multiple Ag-specific memory populations that cover a wide range of

  19. Does strategic defense breed offense

    SciTech Connect

    York, H.

    1987-01-01

    The author examines the question of whether strategic defense activity, in any form, stimulates a related offensive activity. The author studies four post-World II efforts of the superpowers to develop and deploy strategic defenses. The author then derives lessons from those cases that he applies to his analysis of President Reagan's Strategic Defense Initiative. Commentaries on the author's analysis are provided by four scholars.

  20. Strategic weapons

    SciTech Connect

    Not Available

    1991-09-01

    This paper describes the Defense Department's process for formulating its strategic weapons targeting policy and translating that policy into a nuclear war plan-the Single Integrated Operational Plan. GAO provides information on the relationship between the strategic nuclear targeting process and the determination of requirements for nuclear weapons and related delivery systems, level of civilian oversight, and categories and types of targets. These strategic nuclear weapons systems, commonly known as the triad, include land-based intercontinental ballistic missiles, submarine-launched ballistic missiles, and strategic bombers armed with nuclear bombs and missiles.

  1. Initial Flight Test of the Production Support Flight Control Computers at NASA Dryden Flight Research Center

    NASA Technical Reports Server (NTRS)

    Carter, John; Stephenson, Mark

    1999-01-01

    The NASA Dryden Flight Research Center has completed the initial flight test of a modified set of F/A-18 flight control computers that gives the aircraft a research control law capability. The production support flight control computers (PSFCC) provide an increased capability for flight research in the control law, handling qualities, and flight systems areas. The PSFCC feature a research flight control processor that is "piggybacked" onto the baseline F/A-18 flight control system. This research processor allows for pilot selection of research control law operation in flight. To validate flight operation, a replication of a standard F/A-18 control law was programmed into the research processor and flight-tested over a limited envelope. This paper provides a brief description of the system, summarizes the initial flight test of the PSFCC, and describes future experiments for the PSFCC.

  2. DOE EPSCoR Initiative in Structural and computational Biology/Bioinformatics

    SciTech Connect

    Wallace, Susan S.

    2008-02-21

    The overall goal of the DOE EPSCoR Initiative in Structural and Computational Biology was to enhance the competiveness of Vermont research in these scientific areas. To develop self-sustaining infrastructure, we increased the critical mass of faculty, developed shared resources that made junior researchers more competitive for federal research grants, implemented programs to train graduate and undergraduate students who participated in these research areas and provided seed money for research projects. During the time period funded by this DOE initiative: (1) four new faculty were recruited to the University of Vermont using DOE resources, three in Computational Biology and one in Structural Biology; (2) technical support was provided for the Computational and Structural Biology facilities; (3) twenty-two graduate students were directly funded by fellowships; (4) fifteen undergraduate students were supported during the summer; and (5) twenty-eight pilot projects were supported. Taken together these dollars resulted in a plethora of published papers, many in high profile journals in the fields and directly impacted competitive extramural funding based on structural or computational biology resulting in 49 million dollars awarded in grants (Appendix I), a 600% return on investment by DOE, the State and University.

  3. Strategic Genius

    DTIC Science & Technology

    2015-05-21

    Theory: Modern , Symbolic, and Postmodern Perspectives (Oxford: Oxford University Press, 2013), 185–188. 10 status quo solutions remain...York: Oxford University Press, 1999. Hatch, Mary Jo. Organization Theory: Modern , Symbolic, and Postmodern Perspectives. Oxford: Oxford University...elusive strategic genius. What traits make a strategic genius? Several modern theorists examine how such an individual might think and some offer how

  4. An efficient computational algorithm for the initial value problem associated with the universal Y functions

    NASA Astrophysics Data System (ADS)

    Sharaf, M. A.; Saad, A. S.; Fadak, M. A.

    2016-03-01

    In the present paper, an efficient iterative method of arbitrary integer order of convergent ≥ 2 based on the homotopy continuation techniques for the solution of the initial value problem of space dynamics using the universal Y functions is presented. The method is of dynamic nature in the sense that, ongoing from one iterative scheme to the subsequent one, only additional instruction is needed. Most importantly, the method does not need any prior knowledge of the initial guess. This is a property which avoids the critical situations between divergent to very slow convergent solutions that may exist in other numerical methods which depend on initial guesses. A computational package for digital implementation of the method is given, together with numerical applications for elliptic, hyperbolic, and parabolic orbits. The accuracy of the results for all orbits is O(10-16).

  5. Computational Study of the Richtmyer-Meshkov Instability with a Complex Initial Condition

    NASA Astrophysics Data System (ADS)

    McFarland, Jacob; Reilly, David; Greenough, Jeffrey; Ranjan, Devesh

    2014-11-01

    Results are presented for a computational study of the Richtmyer-Meshkov instability with a complex initial condition. This study covers experiments which will be conducted at the newly-built inclined shock tube facility at the Georgia Institute of Technology. The complex initial condition employed consists of an underlying inclined interface perturbation with a broadband spectrum of modes superimposed. A three-dimensional staggered mesh arbitrary Lagrange Eulerian (ALE) hydrodynamics code developed at Lawerence Livermore National Laboratory called ARES was used to obtain both qualitative and quantitative results. Qualitative results are discussed using time series of density plots from which mixing width may be extracted. Quantitative results are also discussed using vorticity fields, circulation components, and energy spectra. The inclined interface case is compared to the complex interface case in order to study the effect of initial conditions on shocked, variable-density flows.

  6. National Nanotechnology Initiative Strategic Plan

    DTIC Science & Technology

    2011-02-01

    development of multimodal carbon nanotube sensing platforms continues with industry partners. The emphasis of these efforts is on development of manufacturing...long cellulose -based products remain in service, are carbon negative or carbon neutral. These cellulosic nanomaterials have strength properties...high-performance structural carbon -based nanomaterials, optical metamaterials, and cellulosic nanomaterials) that have the potential to affect multiple

  7. Seizing the Strategic Communication Initiative

    DTIC Science & Technology

    2010-05-10

    the vast spread of the narcotics trade in the 1980s as the powerful cartels achieved complicity from law enforcement, the judicial system, and...governance through bribery. The corruption even reached as high as a former president. The downfall of the cartels did not end the corruption; it...his election, “when it was discovered that his political campaign had received contributions from the Cali drug cartel .” The FARC never earned the

  8. Micmac Strategic Energy Planning Initiative

    SciTech Connect

    Fred Corey

    2007-02-02

    In February 2005 the Aroostook Band of Micmacs submitted a grant application to the U.S. Department of Energy’s (DOE) Tribal First Steps Program. The purpose of the application was to request funding and technical assistance to identify and document Tribal energy issues, develop a Tribal energy vision, evaluate potential energy opportunities, and to develop an action plan for future Tribal energy activities. The grant application was subsequently funded by DOE, and the Aroostook Band of Micmacs hired an energy consultant to assist with completion of the project. In addition to identification and documentation of Tribal energy issues, and the development of a Tribal energy vision, the potential for wind energy development on Tribal land, and residential energy efficiency issues were thoroughly evaluated.

  9. Perceived Implementation Barriers of a One-to-One Computing Initiative in a Large Urban School District: A Qualitative Approach

    ERIC Educational Resources Information Center

    Simmons, Brandon; Martin, Florence

    2016-01-01

    One-to-One Computing initiatives are K-12 Educational environments where student and teacher have Internet-connected, wireless computing devices in the classroom and optimally at home as well (Penuel, 2006). One-to-one computing has gained popularity in several schools and school districts across the world. However, there is limited research…

  10. 45 CFR 233.25 - Retrospective budgeting; computing the assistance payment after the initial one or two months.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Retrospective budgeting; computing the assistance... ASSISTANCE PROGRAMS § 233.25 Retrospective budgeting; computing the assistance payment after the initial one... assistance under § 233.24, the amount of each subsequent month's payment shall be computed retrospectively,...

  11. Strategic BI for All

    ERIC Educational Resources Information Center

    Raths, David

    2008-01-01

    Implementing a complex business intelligence (BI) system at a small school or one with limited resources can seem daunting. For small to midsize schools and community colleges, a strategic BI initiative may still be an elusive goal. This article discusses how schools with limited resources are making the dream a reality.

  12. Strategic BI for All

    ERIC Educational Resources Information Center

    Raths, David

    2008-01-01

    Implementing a complex business intelligence (BI) system at a small school or one with limited resources can seem daunting. For small to midsize schools and community colleges, a strategic BI initiative may still be an elusive goal. This article discusses how schools with limited resources are making the dream a reality.

  13. Initial screening test for blunt cerebrovascular injury: Validity assessment of whole-body computed tomography.

    PubMed

    Laser, Adriana; Kufera, Joseph A; Bruns, Brandon R; Sliker, Clint W; Tesoriero, Ronald B; Scalea, Thomas M; Stein, Deborah M

    2015-09-01

    Our whole-body computed tomography protocol (WBCT), used to image patients with polytrauma, consists of a noncontrast head computed tomography (CT) followed by a multidetector computed tomography (40- or 64- slice) that includes an intravenous, contrast-enhanced scan from the face through the pelvis. WBCT is used to screen for blunt cerebrovascular injury (BCVI) during initial CT imaging of the patient with polytrauma and allows for early initiation of therapy with the goal of avoiding stroke. WBCT has not been directly compared with CT angiography (CTA) of the neck as a screening tool for BCVI. We hypothesize that WBCT is a valid modality to diagnose BCVI compared with neck CTA, thus screening patients with polytrauma for BCVI and limiting the need for subsequent CTA. A retrospective review of the trauma registry was conducted for all patients diagnosed with BCVI from June 2009 to June 2013 at our institution. All injuries, identified and graded on initial WBCT, were compared with neck CTA imaging performed within the first 72 hours. Sensitivity was calculated for WBCT by the use of CTA as the reference standard. Proportions of agreement also were calculated between the grades of injury for both imaging modalities. A total of 319 injured vessels were identified in 227 patients. On initial WBCT 80 (25%) of the injuries were grade I, 75 (24%) grade II, 45 (14%) grade III, 41 (13%) grade IV, and 58 (18%) were classified as indeterminate: 27 vertebral and 31 carotid lesions. Twenty (6%) of the 319 injuries were not detected on WBCT but identified on subsequent CTA (9 grade I, 7 grade II, 4 grade III); 6 vertebral and 14 carotid. For each vessel type and for all vessels combined, WBCT demonstrated sensitivity rates of over 90% to detect BCVI among the population of patients with at least one vessel injured. There was concordant grading of injuries between WBCT and initial diagnostic CTA in 154 (48% of all injuries). Lower grade injures were more discordant than higher

  14. Computational Study of the Thermodynamics of Atmospheric Nitration of PAHs via OH-Radical-Initiated Reaction

    NASA Astrophysics Data System (ADS)

    Jariyasopit, N.; Cheong, P.; Simonich, S. L.

    2011-12-01

    Nitrated polycyclic aromatic hydrocarbons (NPAHs) are an important class of PAH derivatives that are more toxic than their parent PAHs (1) and are emitted from direct emission and secondary emission to the atmosphere. The secondary emissions, particularly the OH-radical initiated and NO3-radical-initiated reactions, have been shown to influence the NPAH concentrations in the atmosphere. Gas-phase reactions are thought to be the major sources of NPAHs containing four or fewer rings (2). Besides NPAHs, PAHs lead to a number of other products including oxygenated, hydroxy substituted and ring-opened PAH derivatives (3). For some PAHs, the OH-initiated and NO3-initiated reactions result in the formation of different NPAH isomers, allowing the ratio of these isomers to be used in the determination of direct or secondary emission sources. Previous studies have shown that the PAH gas-phase reactions with OH radical is initiated by the addition of OH radical to the aromatic ring to form hydroxycyclohexadienyl radicals (4). In the presence of NO2, these reactive intermediates readily nitrate with the elimination of water (4). The hydroxycyclohexadienyl-type radical intermediates are also prone to react with other species in the atmosphere or revert back to the original compound (3). The objective of this study was to investigate the thermodynamics of PAH nitration through day-time OH-radical-initiated reactions. The theoretical investigation were carried out using Density Functioanl Theory (B3LYP) and the 6-31G(d) basis set, as implemented in Gaussian03. A number of different PAHs were studied including fluoranthene, pyrene, as well as the molecular weight 302 PAHs such as dibenzo[a,l]pyrene. Computations were also used to predict unknown NPAHs formed by OH-radical-initiated reaction. All intermediates for the OH-radical addition and the following nitration were computed. We have discovered that the thermodynamic stability of the intermediates involved in the PAH

  15. Computer predictions of photochemical oxidant levels for initial precursor concentrations characteristic of southeastern Virginia

    NASA Technical Reports Server (NTRS)

    Wakelyn, N. T.; Mclain, A. G.

    1979-01-01

    A computer study was performed with a photochemical box model, using a contemporary chemical mechanism and procedure, and a range of initial input pollutant concentrations thought to encompass those characteristic of the Southeastern Virginia region before a photochemical oxidant episode. The model predictions are consistent with the expectation of high summer afternoon ozone levels when initial nonmethane hydrocarbon (NMHC) levels are in the range 0.30-0.40 ppmC and NOx levels are in the range 0.02-0.05 ppm. Calculations made with a Lagrangian model, for one of the previously calculated cases, which had produced intermediate afternoon ozone levels, suggest that urban source additions of NMHC and NOx exacerbate the photochemical oxidant condition.

  16. Computer simulations on the initiation and morphological difference of Japan winter and summer sprites

    NASA Astrophysics Data System (ADS)

    Asano, Tomokazu; Hayakawa, Masashi; Cho, Mengu; Suzuki, Tomoyuki

    2008-02-01

    Two-dimensional (axisymmetric) computer simulations (electromagnetic code) have been performed to study the initiation and morphological difference (summer, carrots, and winter, columns) of sprites for simulating Japan summer and winter sprites. By changing the physical parameters of a parent lightning, we have found the following findings by looking at the spatial-temporal distribution of reduced electric field, etc. (1) There are three important factors (the height where the charge is removed (ds), charge transfer (Q), and lightning current risetime (τ)) in the initiation of sprites and their morphological differences. (2) For the initiation of sprites, the charge transfer (Q) should exceed a certain value for possible charge heights (giving us a threshold of charge moment change (Qds) of the order of ~120-200 C.km), with a combination of small risetime of lightning current waveform. (3) Further, the height for positive charge is much higher than that for negative charge in a typical lightning configuration, which is the essential factor in determining the morphological difference of sprites in summer and winter. Positive charges for summer are located at a much higher altitude than those in winter in Japan, which might result in carrot-type in summer and columnar-type in winter even for the same positive polarity. (4) A combinational effect of (Ids) and (Qds) is important for having sprites. Finally, the present computer results on the initiation of sprites for Japanese lightning have been compared extensively to the well-documented properties of summer continental sprites and future subjects to study have been suggested.

  17. Computational aspects of the nonlinear normal mode initialization of the GLAS 4th order GCM

    NASA Technical Reports Server (NTRS)

    Navon, I. M.; Bloom, S. C.; Takacs, L.

    1984-01-01

    Using the normal modes of the GLAS 4th Order Model, a Machenhauer nonlinear normal mode initialization (NLNMI) was carried out for the external vertical mode using the GLAS 4th Order shallow water equations model for an equivalent depth corresponding to that associated with the external vertical mode. A simple procedure was devised which was directed at identifying computational modes by following the rate of increase of BAL sub M, the partial (with respect to the zonal wavenumber m) sum of squares of the time change of the normal mode coefficients (for fixed vertical mode index) varying over the latitude index L of symmetric or antisymmetric gravity waves. A working algorithm is presented which speeds up the convergence of the iterative Machenhauer NLNMI. A 24 h integration using the NLNMI state was carried out using both Matsuno and leap-frog time-integration schemes; these runs were then compared to a 24 h integration starting from a non-initialized state. The maximal impact of the nonlinear normal mode initialization was found to occur 6-10 hours after the initial time.

  18. Executive presence for strategic influence.

    PubMed

    Shirey, Maria R

    2013-01-01

    This department highlights change management strategies that may be successful in strategically planning and executing organizational change initiatives. With the goal of presenting practical approaches helpful to nurse leaders advancing organizational change, content includes evidence-based projects, tools, and resources that mobilize and sustain organizational change initiatives. In this article, the author discusses cultivating executive presence, a crucial component of great leadership, needed for strategic influence and to drive change.

  19. Strategic Materials

    DTIC Science & Technology

    2006-01-01

    Sears, US Navy Lt Col Mark Williams, US Air Force Dr. Sylvia Babus , Faculty Dr. Maureen Crandall, Faculty Mr. Bill Jones, Faculty Strategic...graying rapidly, populated predominantly with baby- boomers over 40 years of age. Aggravating this demographic shift, the number of workforce S&E...Transnational Environment. [Student Essay from Strategic Materials Industry Study 2005, available from Dr. Sylvia Babus , Industrial College of the Armed

  20. Leading Strategic & Cultural Change through Technology. Proceedings of the Association of Small Computer Users in Education (ASCUE) Annual Conference (37th, Myrtle Beach, South Carolina, June 6-10, 2004)

    ERIC Educational Resources Information Center

    Smith, Peter, Ed.; Smith, Carol L., Ed.

    2004-01-01

    This 2004 Association of Small Computer Users in Education (ASCUE) conference proceedings presented the theme "Leading Strategic & Cultural Change through Technology." The conference introduced its ASCUE Officers and Directors, and provides abstracts of the pre-conference workshops. The full-text conference papers in this document…

  1. Changes in Cardiovascular Disease Risk Factors With Immediate Versus Deferred Antiretroviral Therapy Initiation Among HIV-Positive Participants in the START (Strategic Timing of Antiretroviral Treatment) Trial.

    PubMed

    Baker, Jason V; Sharma, Shweta; Achhra, Amit C; Bernardino, Jose Ignacio; Bogner, Johannes R; Duprez, Daniel; Emery, Sean; Gazzard, Brian; Gordin, Jonathan; Grandits, Greg; Phillips, Andrew N; Schwarze, Siegfried; Soliman, Elsayed Z; Spector, Stephen A; Tambussi, Giuseppe; Lundgren, Jens

    2017-05-22

    HIV infection and certain antiretroviral therapy (ART) medications increase atherosclerotic cardiovascular disease risk, mediated, in part, through traditional cardiovascular disease risk factors. We studied cardiovascular disease risk factor changes in the START (Strategic Timing of Antiretroviral Treatment) trial, a randomized study of immediate versus deferred ART initiation among HIV-positive persons with CD4(+) cell counts >500 cells/mm(3). Mean change from baseline in risk factors and the incidence of comorbid conditions were compared between groups. The characteristics among 4685 HIV-positive START trial participants include a median age of 36 years, a CD4 cell count of 651 cells/mm(3), an HIV viral load of 12 759 copies/mL, a current smoking status of 32%, a median systolic/diastolic blood pressure of 120/76 mm Hg, and median levels of total cholesterol of 168 mg/dL, low-density lipoprotein cholesterol of 102 mg/dL, and high-density lipoprotein cholesterol of 41 mg/dL. Mean follow-up was 3.0 years. The immediate and deferred ART groups spent 94% and 28% of follow-up time taking ART, respectively. Compared with patients in the deferral group, patients in the immediate ART group had increased total cholesterol and low-density lipoprotein cholesterol and higher use of lipid-lowering therapy (1.2%; 95% CI, 0.1-2.2). Concurrent increases in high-density lipoprotein cholesterol with immediate ART resulted in a 0.1 lower total cholesterol to high-density lipoprotein cholesterol ratio (95% CI, 0.1-0.2). Immediate ART resulted in 2.3% less BP-lowering therapy use (95% CI, 0.9-3.6), but there were no differences in new-onset hypertension or diabetes mellitus. Among HIV-positive persons with preserved immunity, immediate ART led to increases in total cholesterol and low-density lipoprotein cholesterol but also concurrent increases in high-density lipoprotein cholesterol and decreased use of blood pressure medications. These opposing effects suggest that, in

  2. Guidelines for strategic planning

    SciTech Connect

    Not Available

    1991-07-01

    Strategic planning needs to be done as one of the integral steps in fulfilling our overall Departmental mission. The role of strategic planning is to assure that the longer term destinations, goals, and objectives which the programs and activities of the Department are striving towards are the best we can envision today so that our courses can then be set to move in those directions. Strategic planning will assist the Secretary, Deputy Secretary, and Under Secretary in setting the long-term directions and policies for the Department and in making final decisions on near-term priorities and resource allocations. It will assist program developers and implementors by providing the necessary guidance for multi-year program plans and budgets. It is one of the essential steps in the secretary's Strategic Planning Initiative. The operational planning most of us are so familiar with deals with how to get things done and with the resources needed (people, money, facilities, time) to carry out tasks. Operating plans like budgets, capital line item projects, R D budgets, project proposals, etc., are vital to the mission of the Department. They deal, however, with how to carry out programs to achieve some objective or budget assumption. Strategic planning deals with the prior question of what it is that should be attempted. It deals with what objectives the many programs and activities of the Department of Department should be striving toward. The purpose of this document is to provide guidance to those organizations and personnel starting the process for the first time as well as those who have prepared strategic plans in the past and now wish to review and update them. This guideline should not be constructed as a rigid, restrictive or confining rulebook. Each organization is encouraged to develop such enhancements as they think may be useful in their planning. The steps outlined in this document represent a very simplified approach to strategic planning. 9 refs.

  3. Initial Experience with a Cone-beam Breast Computed Tomography-guided Biopsy System

    PubMed Central

    Seifert, Posy J; Morgan, Renee C; Conover, David L; Arieno, Andrea L

    2017-01-01

    Objective: To evaluate our initial experience with a cone-beam breast computed tomography (BCT)-guided breast biopsy system for lesion retrieval in phantom studies for use with a cone-beam BCT imaging system. Materials and Methods: Under the Institutional Review Board approval, a phantom biopsy study was performed using a dedicated BCT-guided biopsy system. Fifteen biopsies were performed on each of the small, medium, and large anthropomorphic breast phantoms with both BCT and stereotactic guidance for comparison. Each set of the 45 phantoms contained masses and calcification clusters of varying sizes. Data included mass/calcium retrieval rate and dose and length of procedure time for phantom studies. Results: Phantom mass and calcium retrieval rate were 100% for BCT and stereotactic biopsy. BCT dose for small and medium breast phantoms was found to be equivalent to or less than the corresponding stereotactic approach. Stereotactic-guided biopsy dose was 34.2 and 62.5 mGy for small and medium breast phantoms, respectively. BCT-guided biopsy dose was 15.4 and 30.0 mGy for small and medium breast phantoms, respectively. Both computed tomography biopsy and stereotactic biopsy study time ranged from 10 to 20 min. Conclusion: Initial experience with a BCT-guided biopsy system has shown to be comparable to stereotactic biopsy in phantom studies with equivalent or decreased dose. PMID:28217404

  4. Strategic Analysis of Terrorism

    NASA Astrophysics Data System (ADS)

    Arce, Daniel G.; Sandler, Todd

    Two areas that are increasingly studied in the game-theoretic literature on terrorism and counterterrorism are collective action and asymmetric information. One contribution of this chapter is a survey and extension of continuous policy models with differentiable payoff functions. In this way, policies can be characterized as strategic substitutes (e. g., proactive measures), or strategic complements (e. g., defensive measures). Mixed substitute-complement models are also introduced. We show that the efficiency of counterterror policy depends upon (i) the strategic substitutes-complements characterization, and (ii) who initiates the action. Surprisingly, in mixed-models the dichotomy between individual and collective action may disappear. A second contribution is the consideration of a signaling model where indiscriminant spectacular terrorist attacks may erode terrorists’ support among its constituency, and proactive government responses can create a backlash effect in favor of terrorists. A novel equilibrium of this model reflects the well-documented ineffectiveness of terrorism in achieving its stated goals.

  5. A new strategic neurosurgical planning tool for brainstem cavernous malformations using interactive computer graphics with multimodal fusion images.

    PubMed

    Kin, Taichi; Nakatomi, Hirofumi; Shojima, Masaaki; Tanaka, Minoru; Ino, Kenji; Mori, Harushi; Kunimatsu, Akira; Oyama, Hiroshi; Saito, Nobuhito

    2012-07-01

    In this study, the authors used preoperative simulation employing 3D computer graphics (interactive computer graphics) to fuse all imaging data for brainstem cavernous malformations. The authors evaluated whether interactive computer graphics or 2D imaging correlated better with the actual operative field, particularly in identifying a developmental venous anomaly (DVA). The study population consisted of 10 patients scheduled for surgical treatment of brainstem cavernous malformations. Data from preoperative imaging (MRI, CT, and 3D rotational angiography) were automatically fused using a normalized mutual information method, and then reconstructed by a hybrid method combining surface rendering and volume rendering methods. With surface rendering, multimodality and multithreshold techniques for 1 tissue were applied. The completed interactive computer graphics were used for simulation of surgical approaches and assumed surgical fields. Preoperative diagnostic rates for a DVA associated with brainstem cavernous malformation were compared between conventional 2D imaging and interactive computer graphics employing receiver operating characteristic (ROC) analysis. The time required for reconstruction of 3D images was 3-6 hours for interactive computer graphics. Observation in interactive mode required approximately 15 minutes. Detailed anatomical information for operative procedures, from the craniotomy to microsurgical operations, could be visualized and simulated three-dimensionally as 1 computer graphic using interactive computer graphics. Virtual surgical views were consistent with actual operative views. This technique was very useful for examining various surgical approaches. Mean (±SEM) area under the ROC curve for rate of DVA diagnosis was significantly better for interactive computer graphics (1.000±0.000) than for 2D imaging (0.766±0.091; p<0.001, Mann-Whitney U-test). The authors report a new method for automatic registration of preoperative imaging data

  6. Air Force Security Assistance Center Foreign Military Sales Center Institutionalizes How It ’Develops and Executes International Agreements" by Linking Strategic Initiatives to the Balanced Scorecard Process

    DTIC Science & Technology

    2004-01-01

    Balanced Scorecard as a Strategic Management System,” Harvard Business Review , January-February: 1975-1985. Pre-LORLORLOA Case Development Case...Management System,” Harvard Business Review , January-February: 1975-1985. The DISAM Journal, Spring 2004 118 Figure 5. Easy To Do Business With 2004

  7. Computational simulation of platelet interactions in the initiation of stent thrombosis due to stent malapposition

    NASA Astrophysics Data System (ADS)

    Chesnutt, Jennifer K. W.; Han, Hai-Chao

    2016-02-01

    Coronary stenting is one of the most commonly used approaches to open coronary arteries blocked due to atherosclerosis. Stent malapposition can induce thrombosis but the microscopic process is poorly understood. The objective of this study was to determine the platelet-level process by which different extents of stent malapposition affect the initiation of stent thrombosis. We utilized a discrete element model to computationally simulate the transport, adhesion, and activation of thousands of individual platelets and red blood cells during thrombus initiation in stented coronary arteries. Simulated arteries contained a malapposed stent with a specified gap distance (0, 10, 25, 50, or 200 μm) between the struts and endothelium. Platelet-level details of thrombus formation near the proximal-most strut were measured during the simulations. The relationship between gap distance and amount of thrombus in the artery varied depending on different conditions (e.g., amount of dysfunctional endothelium, shear-induced activation of platelets, and thrombogenicity of the strut). Without considering shear-induced platelet activation, the largest gap distance (200 μm) produced no recirculation and less thrombus than the smallest two gap distances (0 and 10 μm) that created recirculation downstream of the strut. However, with the occurrence of shear-induced platelet activation, the largest gap distance produced more thrombus than the two smallest gap distances, but less thrombus than an intermediate gap distance (25 μm). A large gap distance was not necessarily the most thrombogenic, in contrast to implications of some computational fluid dynamics studies. The severity of stent malapposition affected initial stent thrombosis differently depending on various factors related to fluid recirculation, platelet trajectories, shear stress, and endothelial condition.

  8. Purdue Extended Campus: Transparency, Accountability, and Assessment in Strategic Planning

    ERIC Educational Resources Information Center

    Cunningham, Robin; Eddy, Michael; Pagano, Mark; Ncube, Lisa

    2011-01-01

    In 2002 President Martin Jischke initiated a new era in strategic planning at Purdue. Under his leadership, strategic planning became a centralized activity with unit plans aligned to the university plan. Strategic goals were designed to have maximum impact, which would be measurable through metrics. Strategic planning at Purdue would be an…

  9. Computational evidence for self-initiation in spontaneous high-temperature polymerization of methyl methacrylate.

    PubMed

    Srinivasan, Sriraj; Lee, Myung Won; Grady, Michael C; Soroush, Masoud; Rappe, Andrew M

    2011-02-17

    This paper presents computational evidence for the occurrence of diradical mechanism of self-initiation in thermal polymerization of methyl methacrylate. Two self-initiation mechanisms of interest were explored with first-principles density functional theory calculations. Singlet and triplet potential energy surfaces were constructed. The formation of two Diels-Alder adducts, cis- and trans-dimethyl 1,2-dimethylcyclobutane-1,2-dicarboxylate and dimethyl 2-methyl-5-methylidene-hexanedioate, on the singlet surface was identified. Transition states were calculated using B3LYP/6-31G* and assessed using MP2/6-31G*. The calculated energy barriers and rate constants with different levels of theory were found to show good agreement to corresponding data obtained from laboratory experiments. The presence of a diradical intermediate on the triplet surface was identified. When MCSCF/6-31G* was used, the spin-orbit coupling constant for the singlet to triplet crossover was calculated to be 2.5 cm(-1). The mechanism of monoradical generation via a hydrogen abstraction by both triplet and singlet diradicals from a third monomer was identified to be the most likely mechanism of initiation in spontaneous polymerization of methyl methacrylate.

  10. Computational study of the self-initiation mechanism in thermal polymerization of methyl acrylate.

    PubMed

    Srinivasan, Sriraj; Lee, Myung Won; Grady, Michael C; Soroush, Masoud; Rappe, Andrew M

    2009-10-08

    This computational study deals with the mechanism of spontaneous initiation in thermal polymerization of alkyl acrylates (e.g., methyl, ethyl, and n-butyl acrylate). The mechanism is presently still unknown. Density-functional theory (DFT) and Møller-Plesset (MP2) calculations are used to explore the Flory and Mayo mechanisms of self-initiation in methyl acrylate. On the singlet surface, a low-barrier, concerted [4 + 2] Diels-Alder mechanism for the formation of a dihydropyran adduct (DA) and a high-barrier nonconcerted [2 + 2] diradical ((*)M(2s)(*)) mechanism for the formation of dimethyl cyclobutane-1,2-dicarboxylate (DCD) were found using B3LYP/6-31G*. Several levels of theory were used to validate the transition states, and the pathways for the DA and DCD formations on the singlet surface were determined using intrinsic reaction coordinate (IRC) calculations. On the triplet surface, a triplet diradical intermediate ((*)M(2t)(*)) was identified that is structurally similar to (*)M(2s)(*) but lower in energy. The spin-orbit coupling constant for crossover of the diradical from singlet to triplet surface was calculated. Monoradical generation from the two intermediates, DA and (*)M(2t)(*) via hydrogen transfer to or from a third methyl acrylate was studied. It was found that generation of two monoradical species was possible from (*)M(2t)(*) and is proposed as a likely explanation for experimentally observed spontaneous-initiation.

  11. Symbolic computation of analytic approximate solutions for nonlinear differential equations with initial conditions

    NASA Astrophysics Data System (ADS)

    Lin, Yezhi; Liu, Yinping; Li, Zhibin

    2012-01-01

    The Adomian decomposition method (ADM) is one of the most effective methods for constructing analytic approximate solutions of nonlinear differential equations. In this paper, based on the new definition of the Adomian polynomials, and the two-step Adomian decomposition method (TSADM) combined with the Padé technique, a new algorithm is proposed to construct accurate analytic approximations of nonlinear differential equations with initial conditions. Furthermore, a MAPLE package is developed, which is user-friendly and efficient. One only needs to input a system, initial conditions and several necessary parameters, then our package will automatically deliver analytic approximate solutions within a few seconds. Several different types of examples are given to illustrate the validity of the package. Our program provides a helpful and easy-to-use tool in science and engineering to deal with initial value problems. Program summaryProgram title: NAPA Catalogue identifier: AEJZ_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEJZ_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 4060 No. of bytes in distributed program, including test data, etc.: 113 498 Distribution format: tar.gz Programming language: MAPLE R13 Computer: PC Operating system: Windows XP/7 RAM: 2 Gbytes Classification: 4.3 Nature of problem: Solve nonlinear differential equations with initial conditions. Solution method: Adomian decomposition method and Padé technique. Running time: Seconds at most in routine uses of the program. Special tasks may take up to some minutes.

  12. Initial Inductive Learning in a Complex Computer Simulated Environment: The Role of Metacognitive Skills and Intellectual Ability.

    ERIC Educational Resources Information Center

    Veenman, M. V. J.; Prins, F. J.; Elshout, J. J.

    2002-01-01

    Discusses conceptual knowledge acquisition using computer simulation and describes a study of undergraduates that examined the role of metacognitive skillfulness and intellectual ability during initial inductive learning with a complex computer simulation. Results showed that metacognitive skillfulness was positively related to learning behavior…

  13. The Relationship between Teachers' Computer Self-Efficacy and Technology Integration in a School District's Bring Your Own Technology Initiative

    ERIC Educational Resources Information Center

    Ellis, Ashley F.

    2014-01-01

    The purpose of this mixed methods program evaluation study was to investigate the ways in which one public school district and its teachers implemented a Bring Your Own Technology (BYOT) initiative. This study also measured teachers' computer self-efficacy, as measured by Cassidy and Eachus' (2002) Computer User Self-Efficacy Scale, and…

  14. The Relationship between Teachers' Computer Self-Efficacy and Technology Integration in a School District's Bring Your Own Technology Initiative

    ERIC Educational Resources Information Center

    Ellis, Ashley F.

    2014-01-01

    The purpose of this mixed methods program evaluation study was to investigate the ways in which one public school district and its teachers implemented a Bring Your Own Technology (BYOT) initiative. This study also measured teachers' computer self-efficacy, as measured by Cassidy and Eachus' (2002) Computer User Self-Efficacy Scale, and…

  15. 45 CFR 233.25 - Retrospective budgeting; computing the assistance payment after the initial one or two months.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 2 2011-10-01 2011-10-01 false Retrospective budgeting; computing the assistance... FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES COVERAGE AND CONDITIONS OF ELIGIBILITY IN FINANCIAL ASSISTANCE PROGRAMS § 233.25 Retrospective budgeting; computing the assistance payment after the initial...

  16. Computational study of 3-D hot-spot initiation in shocked insensitive high-explosive

    NASA Astrophysics Data System (ADS)

    Najjar, F. M.; Howard, W. M.; Fried, L. E.; Manaa, M. R.; Nichols, A., III; Levesque, G.

    2012-03-01

    High-explosive (HE) material consists of large-sized grains with micron-sized embedded impurities and pores. Under various mechanical/thermal insults, these pores collapse generating hightemperature regions leading to ignition. A hydrodynamic study has been performed to investigate the mechanisms of pore collapse and hot spot initiation in TATB crystals, employing a multiphysics code, ALE3D, coupled to the chemistry module, Cheetah. This computational study includes reactive dynamics. Two-dimensional high-resolution large-scale meso-scale simulations have been performed. The parameter space is systematically studied by considering various shock strengths, pore diameters and multiple pore configurations. Preliminary 3-D simulations are undertaken to quantify the 3-D dynamics.

  17. An Interactive Computer Session to Initiate Physical Activity in Sedentary Cardiac Patients: Randomized Controlled Trial

    PubMed Central

    Smith-Ray, Renae L; Dzewaltowski, David A; Glasgow, Russell E; Lee, Rebecca E; Thomas, Deborah SK; Xu, Stanley; Estabrooks, Paul A

    2015-01-01

    Background Physical activity (PA) improves many facets of health. Despite this, the majority of American adults are insufficiently active. Adults who visit a physician complaining of chest pain and related cardiovascular symptoms are often referred for further testing. However, when this testing does not reveal an underlying disease or pathology, patients typically receive no additional standard care services. A PA intervention delivered within the clinic setting may be an effective strategy for improving the health of this population at a time when they may be motivated to take preventive action. Objective Our aim was to determine the effectiveness of a tailored, computer-based, interactive personal action planning session to initiate PA among a group of sedentary cardiac patients following exercise treadmill testing (ETT). Methods This study was part of a larger 2x2 randomized controlled trial to determine the impact of environmental and social-cognitive intervention approaches on the initiation and maintenance of weekly PA for patients post ETT. Participants who were referred to an ETT center but had a negative-test (ie, stress tests results indicated no apparent cardiac issues) were randomized to one of four treatment arms: (1) increased environmental accessibility to PA resources via the provision of a free voucher to a fitness facility in close proximity to their home or workplace (ENV), (2) a tailored social cognitive intervention (SC) using a “5 As”-based (ask, advise, assess, assist, and arrange) personal action planning tool, (3) combined intervention of both ENV and SC approaches (COMBO), or (4) a matched contact nutrition control (CON). Each intervention was delivered using a computer-based interactive session. A general linear model for repeated measures was conducted with change in PA behavior from baseline to 1-month post interactive computer session as the primary outcome. Results Sedentary participants (n=452; 34.7% participation rate) without

  18. An Interactive Computer Session to Initiate Physical Activity in Sedentary Cardiac Patients: Randomized Controlled Trial.

    PubMed

    Almeida, Fabio A; Smith-Ray, Renae L; Dzewaltowski, David A; Glasgow, Russell E; Lee, Rebecca E; Thomas, Deborah S K; Xu, Stanley; Estabrooks, Paul A

    2015-08-24

    Physical activity (PA) improves many facets of health. Despite this, the majority of American adults are insufficiently active. Adults who visit a physician complaining of chest pain and related cardiovascular symptoms are often referred for further testing. However, when this testing does not reveal an underlying disease or pathology, patients typically receive no additional standard care services. A PA intervention delivered within the clinic setting may be an effective strategy for improving the health of this population at a time when they may be motivated to take preventive action. Our aim was to determine the effectiveness of a tailored, computer-based, interactive personal action planning session to initiate PA among a group of sedentary cardiac patients following exercise treadmill testing (ETT). This study was part of a larger 2x2 randomized controlled trial to determine the impact of environmental and social-cognitive intervention approaches on the initiation and maintenance of weekly PA for patients post ETT. Participants who were referred to an ETT center but had a negative-test (ie, stress tests results indicated no apparent cardiac issues) were randomized to one of four treatment arms: (1) increased environmental accessibility to PA resources via the provision of a free voucher to a fitness facility in close proximity to their home or workplace (ENV), (2) a tailored social cognitive intervention (SC) using a "5 As"-based (ask, advise, assess, assist, and arrange) personal action planning tool, (3) combined intervention of both ENV and SC approaches (COMBO), or (4) a matched contact nutrition control (CON). Each intervention was delivered using a computer-based interactive session. A general linear model for repeated measures was conducted with change in PA behavior from baseline to 1-month post interactive computer session as the primary outcome. Sedentary participants (n=452; 34.7% participation rate) without a gym membership (mean age 58.57 years

  19. Neural correlates of user-initiated motor success and failure - A brain-computer interface perspective.

    PubMed

    Yazmir, Boris; Reiner, Miriam

    2016-11-02

    Any motor action is, by nature, potentially accompanied by human errors. In order to facilitate development of error-tailored Brain-Computer Interface (BCI) correction systems, we focused on internal, human-initiated errors, and investigated EEG correlates of user outcome successes and errors during a continuous 3D virtual tennis game against a computer player. We used a multisensory, 3D, highly immersive environment. Missing and repelling the tennis ball were considered, as 'error' (miss) and 'success' (repel). Unlike most previous studies, where the environment "encouraged" the participant to perform a mistake, here errors happened naturally, resulting from motor-perceptual-cognitive processes of incorrect estimation of the ball kinematics, and can be regarded as user internal, self-initiated errors. Results show distinct and well-defined Event-Related Potentials (ERPs), embedded in the ongoing EEG, that differ across conditions by waveforms, scalp signal distribution maps, source estimation results (sLORETA) and time-frequency patterns, establishing a series of typical features that allow valid discrimination between user internal outcome success and error. The significant delay in latency between positive peaks of error- and success-related ERPs, suggests a cross-talk between top-down and bottom-up processing, represented by an outcome recognition process, in the context of the game world. Success-related ERPs had a central scalp distribution, while error-related ERPs were centro-parietal. The unique characteristics and sharp differences between EEG correlates of error/success provide the crucial components for an improved BCI system. The features of the EEG waveform can be used to detect user action outcome, to be fed into the BCI correction system. Copyright © 2016 IBRO. Published by Elsevier Ltd. All rights reserved.

  20. Flat panel computed tomography of human ex vivo heart and bone specimens: initial experience.

    PubMed

    Nikolaou, Konstantin; Flohr, Thomas; Stierstorfer, Karl; Becker, Christoph R; Reiser, Maximilian F

    2005-02-01

    The aim of this technical investigation was the detailed description of a prototype flat panel detector computed tomography system (FPCT) and its initial evaluation in an ex vivo setting. The prototype FPCT scanner consists of a conventional radiographic flat panel detector, mounted on a multi-slice CT scanner gantry. Explanted human ex vivo heart and foot specimens were examined. Images were reformatted with various reconstruction algorithms and were evaluated for high-resolution anatomic information. For comparison purposes, the ex vivo specimens were also scanned with a conventional 16-detector-row CT scanner (Sensation 16, Siemens Medical Solutions, Forchheim, Germany). With the FPCT prototype used, a 1,024x768 resolution matrix can be obtained, resulting in an isotropic voxel size of 0.25x0.25x0.25 mm at the iso-center. Due to the high spatial resolution, very small structures such as trabecular bone or third-degree, distal branches of coronary arteries could be visualized. This first evaluation showed that flat panel detector systems can be used in a cone-beam computed tomography scanner and that very high spatial resolutions can be achieved. However, there are limitations for in vivo use due to constraints in low contrast resolution and slow scan speed.

  1. Computation of Material Demand in the Risk Assessment and Mitigation Framework for Strategic Materials (RAMF-SM) Process

    DTIC Science & Technology

    2015-08-01

    commonly used one involves quantities called material consumption ratios, which are generally based on data from the Department of Commerce and the...5  3.  The Material Consumption Ratio Methodology...through material consumption information, via the methodology discussed in this paper.  Substep 2c accepts initial material supply levels and

  2. Bioprocess monitoring and computer control: key roots of the current PAT initiative.

    PubMed

    Junker, B H; Wang, H Y

    2006-10-05

    This review article has been written for the journal, Biotechnology and Bioengineering, to commemorate the 70th birthday of Daniel I.C. Wang, who served as doctoral thesis advisor to each of the co-authors, but a decade apart. Key roots of the current PAT initiative in bioprocess monitoring and control are described, focusing on the impact of Danny Wang's research as a professor at MIT. The history of computer control and monitoring in biochemical processing has been used to identify the areas that have already benefited and those that are most likely to benefit in the future from PAT applications. Past applications have included the use of indirect estimation methods for cell density, expansion of on-line/at-line and on-line/in situ measurement techniques, and development of models and expert systems for control and optimization. Future applications are likely to encompass additional novel measurement technologies, measurements for multi-scale and disposable bioreactors, real time batch release, and more efficient data utilization to achieve process validation and continuous improvement goals. Dan Wang's substantial contributions in this arena have been one key factor in steering the PAT initiative towards realistic and attainable industrial applications.

  3. Innovative science and technology (IST) in support of SDI (Strategic Defense Initiative) BM/C3 (Battle Management/Command, Control and Communications). Final report, June 1987-March 1988

    SciTech Connect

    Balko, B.; Albini, F.A.; Cohen, L.; Penner, S.S.; Sworder, D.D.

    1988-08-01

    Battle Management and Command, Control and Communications (BM/C3) issues in the Strategic Defense Initiative (SDI) context were discussed at a two-day workshop at the Institute for Defense Analyses (IDA). Another workshop-probed civilian systems that require handling of large amounts of data and that have fault-tolerant features that may be useful in resolving the SDI BM/C3 problems. The findings are summarized in this report, with special emphasis on possible research to be supported by the Innovative Science and Technology Office of SDIO.

  4. Strategic Bonding.

    ERIC Educational Resources Information Center

    Davis, Lynn; Tyson, Ben

    2003-01-01

    Many school buildings are in dire need of renovation, expansion, or replacement. Brief case studies from around the country illustrate the importance of finding out why people vote for or against a construction referendum. Lists recommendations for a strategic campaign. (MLF)

  5. Strategic HRD.

    ERIC Educational Resources Information Center

    1997

    This document contains four papers from a symposium on strategic human resource development (HRD). "Examination of the Use of Scenarios as Learning and Decision-Making Tools for Human Resource Development" (Roger F. Miller, Susan A. Lynham, Joanne Provo, Jeanne M. St. Claire) explores the potential value of scenarios as learning and…

  6. Strategic Staffing

    ERIC Educational Resources Information Center

    Clark, Ann B.

    2012-01-01

    Business and industry leaders do not flinch at the idea of placing top talent in struggling departments and divisions. This is not always the case in public education. The Charlotte-Mecklenburg Schools made a bold statement to its community in its strategic plan by identifying two key reform levers--(1) an effective principal leading each school;…

  7. Strategic HRD.

    ERIC Educational Resources Information Center

    1997

    This document contains four papers from a symposium on strategic human resource development (HRD). "Examination of the Use of Scenarios as Learning and Decision-Making Tools for Human Resource Development" (Roger F. Miller, Susan A. Lynham, Joanne Provo, Jeanne M. St. Claire) explores the potential value of scenarios as learning and…

  8. Development and Initial Validation of an Instrument to Measure Physicians' Use of, Knowledge about, and Attitudes Toward Computers

    PubMed Central

    Cork, Randy D.; Detmer, William M.; Friedman, Charles P.

    1998-01-01

    , computer training, and self-reported computer sophistication. In addition, items posited on the computer knowledge scale to be more difficult generated significantly lower scores. Conclusion: The four scales of the questionnaire appear to measure with adequate reliability five attributes of academic physicians' attitudes toward computers in medical care: computer use, self-reported computer knowledge, demand for computer functionality, demand for computer usability, and computer optimism. Results of initial validity studies are positive, but further validation of the scales is needed. The URL of a downloadable HTML copy of the questionnaire is provided. PMID:9524349

  9. Strategic Supply

    DTIC Science & Technology

    2006-01-01

    leaders as Sears, Limited Brands, DHL, Circuit City, Cingular, Nestle and IKEA (Manugistics, 2006). The Strategic Supply Chain Industry Study Group...inventory turns have increased. Other global customers have also reaped the benefits of the Manugistics software. IKEA , Sweden’s retail icon...turned to Manugistics after a mid-1990s ERP implementation failed to fix their forecasting problems, which gave way to fluctuating inventory levels. IKEA

  10. Computational Study of 3-D Hot-Spot Initiation in Shocked Insensitive High-Explosive

    NASA Astrophysics Data System (ADS)

    Najjar, F. M.; Howard, W. M.; Fried, L. E.

    2011-06-01

    High explosive shock sensitivity is controlled by a combination of mechanical response, thermal properties, and chemical properties. The interplay of these physical phenomena in realistic condensed energetic materials is currently lacking. A multiscale computational framework is developed investigating hot spot (void) ignition in a single crystal of an insensitive HE, TATB. Atomistic MD simulations are performed to provide the key chemical reactions and these reaction rates are used in 3-D multiphysics simulations. The multiphysics code, ALE3D, is linked to the chemistry software, Cheetah, and a three-way coupled approach is pursued including hydrodynamics, thermal and chemical analyses. A single spherical air bubble is embedded in the insensitive HE and its collapse due to shock initiation is evolved numerically in time; while the ignition processes due chemical reactions are studied. Our current predictions showcase several interesting features regarding hot spot dynamics including the formation of a ``secondary'' jet. Results obtained with hydro-thermo-chemical processes leading to ignition growth will be discussed for various pore sizes and different shock pressures. LLNL-ABS-471438. This work performed under the auspices of the U.S. Department of Energy by LLNL under Contract DE-AC52-07NA27344.

  11. Strategic arms limitation

    NASA Astrophysics Data System (ADS)

    Allen Greb, G.; Johnson, Gerald W.

    1983-10-01

    Following World War II, American scientists and politicians proposed in the Baruch plan a radical solution to the problem of nuclear weapons: to eliminate them forever under the auspices of an international nuclear development authority. The Soviets, who as yet did not possess the bomb, rejected this plan. Another approach suggested by Secretary of War Henry Stimson to negotiate directly with the Soviet Union was not accepted by the American leadership. These initial arms limitation failures both reflected and exacerbated the hostile political relationship of the superpowers in the 1950s and 1960s. Since 1969, the more modest focus of the Soviet-American arms control process has been on limiting the numbers and sizes of both defensive and offensive strategic systems. The format for this effort has been the Strategic Arms Limitatins Talks (Salt) and more recently the Strategic Arms Reduction Talks (START). Both sides came to these negotiations convinced that nuclear arsenals had grown so large that some for of mutual restraint was needed. Although the SALT/START process has been slow and ponderous, it has produced several concrete the agreements and collateral benefits. The 1972 ABM Treaty restricts the deployment of ballistic missile defense systems, the 1972 Interim Agreement places a quantitative freeze on each side's land based and sea based strategic launchers, and the as yet unratified 1979 SALT II Treaty sets numerical limits on all offensive strategic systems and sublimits on MIRVed systems. Collateral benefits include improved verification procedures, working definitions and counting rules, and permanent bureaucratic apparatus which enhance stability and increase the chances for achieving additional agreements.

  12. Initial Testing of a Two-Dimensional Computer Code for Microwave-Induced Surface Breakdown in Air

    DTIC Science & Technology

    1991-06-01

    operation of high- voltage electrical equipment are electron emission and surface flashover . As a step toward further understanding of these phenomena in gas...INITIAL TESTING OF A TWO-DIMENSIONAL COMPUTER CODE FOR MICROWAVE-INDUCED SURFACE BREAKDOWN IN AIR* D.J. Mayhall and J.H. Yee Lawrence Livermore...computer code for microwave-induced surface breakdown in air is developed. This code is based on finite difference approximations to Maxwell’s curl

  13. Star wars: A question of initiative

    SciTech Connect

    Ennals, R.

    1987-01-01

    This book discusses U.K. and European participation in the Strategic Defense Initiative. The author, a cofounder of The Strategic Research Initiative, participated in research and research management concerned with developing tools for analyzing the complexity of nuclear diplomacy and how international politics are affected by the new technology. It covers research and varying national strategies for applying advanced information technology, intelligent machinery, logic programming in both education and training, and artificial intelligence issues. It introduces the field of computational politics, examining the political importance of computer systems and computational concepts that can help analyze complex political phenomena. It also gives special attention to the American SDI, ''Star Wars,'' which has necessitated the development and deployment of new techniques of political analysis. A section on constructive alternatives to SDI is also included.

  14. High Performance Embedded Computing Software Initiative (HPEC-SI) Program Facilitation of VSIPL++ Standardization

    DTIC Science & Technology

    2008-04-01

    parallel VSIPL++, and other parallel computing systems. The cluster is a fifty five node Beowulf style cluster with 116 compute processors of varying types...consoles, which GTRI inserted into to the parallel software testbed. A computer that is used as a compute node in a Beowulf -style cluster requires a... Beowulf -style cluster. GTRI also participated in technical advisory planning for the HPEC-SI program. 5. References 1. Schwartz, D. A ., Judd, R. R

  15. Inexpensive video-laryngoscopy guided intubation using a personal computer: initial experience of a novel technique.

    PubMed

    Karippacheril, John George; Umesh, Goneppanavar; Ramkumar, Venkateswaran

    2014-06-01

    Video-laryngoscopy may provide an enhanced view of laryngeal structures compared to direct visualization. Commercial video-laryngoscopes are often expensive, limiting its adoption for routine use. We describe our initial experience using an inexpensive custom made device. Patients >15 years age, were randomly chosen, after informed consent, for video-laryngoscopy. A custom device easily assembled using an USB endoscopic camera, a conventional Macintosh laryngoscope blade size 3 or 4, and a personal computer was used. Patients with Mallampati class 1-3 were chosen. Video-laryngoscopy was recorded and reviewed. Twenty-four patients aged 16-68 years, of mean weight 58.46 ± 12.54 (40-86) kg were studied. The glottis could be visualized and intubation could be performed in all patients with 22/24 patients on first attempt. Mean duration of laryngoscopy was 22.17 ± 12.78 (7-59) s. Time taken for intubation, was mean of 28.58 ± 21.01 (9-89) s. Three patients with anticipated difficult airways could be intubated on the first attempt. Minor blood staining of the airway was seen in the video in two patients. Cormack-Lehane laryngoscopy grade visualized was 1 in 9/24, 2 in 15/24 patients. Percentage of glottic opening score was 62.29 ± 28.40 (20-100) %. Real-time video could be captured in all cases. The custom-made, inexpensive, video-laryngoscopy device is safe and reliable for clinical use. Real-time visualization and endotracheal intubation were successful in all patients, including those with anticipated difficult airway. Further, this device helps in archiving the video of intubation.

  16. PAH growth initiated by propargyl addition: mechanism development and computational kinetics.

    PubMed

    Raj, Abhijeet; Al Rashidi, Mariam J; Chung, Suk Ho; Sarathy, S Mani

    2014-04-24

    Polycyclic aromatic hydrocarbon (PAH) growth is known to be the principal pathway to soot formation during fuel combustion, as such, a physical understanding of the PAH growth mechanism is needed to effectively assess, predict, and control soot formation in flames. Although the hydrogen abstraction C2H2 addition (HACA) mechanism is believed to be the main contributor to PAH growth, it has been shown to under-predict some of the experimental data on PAHs and soot concentrations in flames. This article presents a submechanism of PAH growth that is initiated by propargyl (C3H3) addition onto naphthalene (A2) and the naphthyl radical. C3H3 has been chosen since it is known to be a precursor of benzene in combustion and has appreciable concentrations in flames. This mechanism has been developed up to the formation of pyrene (A4), and the temperature-dependent kinetics of each elementary reaction has been determined using density functional theory (DFT) computations at the B3LYP/6-311++G(d,p) level of theory and transition state theory (TST). H-abstraction, H-addition, H-migration, β-scission, and intramolecular addition reactions have been taken into account. The energy barriers of the two main pathways (H-abstraction and H-addition) were found to be relatively small if not negative, whereas the energy barriers of the other pathways were in the range of (6-89 kcal·mol(-1)). The rates reported in this study may be extrapolated to larger PAH molecules that have a zigzag site similar to that in naphthalene, and the mechanism presented herein may be used as a complement to the HACA mechanism to improve prediction of PAH and soot formation.

  17. Toward a Semi-Self-Paced EEG Brain Computer Interface: Decoding Initiation State from Non-Initiation State in Dedicated Time Slots

    PubMed Central

    Yang, Lingling; Leung, Howard; Peterson, David A.; Sejnowski, Terrence J.; Poizner, Howard

    2014-01-01

    Brain computer interfaces (BCIs) offer a broad class of neurologically impaired individuals an alternative means to interact with the environment. Many BCIs are “synchronous” systems, in which the system sets the timing of the interaction and tries to infer what control command the subject is issuing at each prompting. In contrast, in “asynchronous” BCIs subjects pace the interaction and the system must determine when the subject’s control command occurs. In this paper we propose a new idea for BCI which draws upon the strengths of both approaches. The subjects are externally paced and the BCI is able to determine when control commands are issued by decoding the subject’s intention for initiating control in dedicated time slots. A single task with randomly interleaved trials was designed to test whether it can be used as stimulus for inducing initiation and non-initiation states when the sensory and motor requirements for the two types of trials are very nearly identical. Further, the essential problem on the discrimination between initiation state and non-initiation state was studied. We tested the ability of EEG spectral power to distinguish between these two states. Among the four standard EEG frequency bands, beta band power recorded over parietal-occipital cortices provided the best performance, achieving an average accuracy of 86% for the correct classification of initiation and non-initiation states. Moreover, delta band power recorded over parietal and motor areas yielded a good performance and thus could also be used as an alternative feature to discriminate these two mental states. The results demonstrate the viability of our proposed idea for a BCI design based on conventional EEG features. Our proposal offers the potential to mitigate the signal detection challenges of fully asynchronous BCIs, while providing greater flexibility to the subject than traditional synchronous BCIs. PMID:24586440

  18. Overcoming Relationship-Initiation Barriers: The Impact of a Computer-Dating System on Sex Role, Shyness, and Appearance Inhibitions.

    ERIC Educational Resources Information Center

    Scharlott, Bradford W.; Christ, William G.

    1995-01-01

    A survey of the users of an online computer-mediated matchmaking service showed that their communication patterns and objectives varied by their sex, shyness level, and appearance. Intrinsic aspects of this system helped some users overcome relationship-initiation barriers rooted in sex role, shyness, and appearance inhibitions. (Author)

  19. Overcoming Relationship-Initiation Barriers: The Impact of a Computer-Dating System on Sex Role, Shyness, and Appearance Inhibitions.

    ERIC Educational Resources Information Center

    Scharlott, Bradford W.; Christ, William G.

    1995-01-01

    A survey of the users of an online computer-mediated matchmaking service showed that their communication patterns and objectives varied by their sex, shyness level, and appearance. Intrinsic aspects of this system helped some users overcome relationship-initiation barriers rooted in sex role, shyness, and appearance inhibitions. (Author)

  20. 45 CFR 233.35 - Computing the assistance payment under retrospective budgeting after the initial one or two...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... FINANCIAL ASSISTANCE PROGRAMS § 233.35 Computing the assistance payment under retrospective budgeting after... retrospective budgeting after the initial one or two months (AFDC). 233.35 Section 233.35 Public Welfare... retrospective budgeting is used, the State shall not count income from the budget month already considered...

  1. Strategic Plan: July 2010 to June 2013

    ERIC Educational Resources Information Center

    California State Library, 2010

    2010-01-01

    On June 15-16, 2010, California State Librarian Stacey A. Aldrich, initiated a strategic planning summit in Sacramento, California. The purpose of the summit was to build the future pathways for the California State Library (CSL)--one of California's oldest cultural institutions. This was accomplished by developing a CSL strategic plan (values,…

  2. Smart strategic planning for cardiovascular services.

    PubMed

    Hartman, Karen

    2005-12-01

    Strategic planning for cardiovascular services should include formation of a cardiovascular advisory committee composed of key stakeholders. The strategic plan should include an internal assessment, external market analysis, review of operations, development of strategies and initiatives, and a financial analysis. The organization's mission and vision, as well as its financial situation, need to be considered in formulating strategies.

  3. Soviet strategic defense technology

    SciTech Connect

    Stubbs, E.

    1987-04-01

    The present status of the Soviet program suggests several observations that have a bearing on predicting the future of the Soviet strategic defense program and its implications for the US: 1. The Soviet Union appears to have a continuing interest in ABM defenses, although ASATs seem to be a much lower priority. 2. The Soviet technology fielded to date was well within the American grasp 10 years ago. Where advanced and as yet undeployed technologies are concerned, the difference seems to be smaller; perhaps as little as five or seven years, with approximate parity in particle-beam research. 3. The Soviet Union, possibly more sensitive to prestige considerations, appears to be much more inclined than the US to demonstrate and deploy a technology before it is actually fully operational, and to undertake field modifications later. They also are much more reluctant to retire aging and obsolete technologies. As a result, they presently possess the world's only deployed ASAT and ABM systems, however, doubtful their actual operational effectiveness might be. 4. Soviet strategic defenses tend to be more fragmentary in design, reflecting their difficulties with the supporting and integrative technologies such as sensing, signal processing, heavy-lift boosters, and computing hardware and software. 5. The Soviets should also be expected to explore alternative avenues of near-term response to SDI, for example by expanding their strategic nuclear arsenal. 28 references, 1 figure, 2 tables.

  4. Hospital strategic preparedness planning: the new imperative.

    PubMed

    Ginter, Peter M; Duncan, W Jack; Abdolrasulnia, Maziar

    2007-01-01

    Strategic preparedness planning is an important new imperative for many hospitals. Strategic preparedness planning goes beyond traditional product/market strategic planning by focusing on disaster prevention, containment, and response roles. Hospitals, because of their unique mission, size, complexity, the types of materials they handle, and the types of patients they encounter, are especially vulnerable to natural and human-initiated disasters. In addition, when disasters occur, hospitals must develop well-conceived first responder (receiver) strategies. This paper argues the case for strategic preparedness planning for hospitals and proposes a process for this relatively new and much needed type of planning.

  5. Porcine Ex Vivo Liver Phantom for Dynamic Contrast-Enhanced Computed Tomography: Development and Initial Results

    PubMed Central

    Thompson, Scott M.; Giraldo, Juan C. Ramirez; Knudsen, Bruce; Grande, Joseph P.; Christner, Jodie A.; Xu, Man; Woodrum, David A.; McCollough, Cynthia H.; Callstrom, Matthew R.

    2011-01-01

    Objectives To demonstrate the feasibility of developing a fixed, dual-input, biological liver phantom for dynamic contrast-enhanced computed tomography (CT) imaging and to report initial results of use of the phantom for quantitative CT perfusion imaging. Materials and Methods Porcine livers were obtained from completed surgical studies and perfused with saline and fixative. The phantom was placed in a body-shaped, CT-compatible acrylic container and connected to a perfusion circuit fitted with a contrast injection port. Flow-controlled contrast-enhanced imaging experiments were performed using a 128-slice and 64 slice, dual-source multidetector CT scanners. CT angiography protocols were employed to obtain portal venous and hepatic arterial vascular enhancement, reproduced over a period of four to six months. CT perfusion protocols were employed at different input flow rates to correlate input flow with calculated tissue perfusion, to test reproducibility and demonstrate the feasibility of simultaneous dual input liver perfusion. Histologic analysis of the liver phantom was also performed. Results CT angiogram 3D reconstructions demonstrated homogenous tertiary and quaternary branching of the portal venous system out to the periphery of all lobes of the liver as well as enhancement of the hepatic arterial system to all lobes of the liver and gallbladder throughout the study period. For perfusion CT, the correlation between the calculated mean tissue perfusion in a volume of interest and input pump flow rate was excellent (R2 = 0.996) and color blood flow maps demonstrated variations in regional perfusion in a narrow range. Repeat perfusion CT experiments demonstrated reproducible time-attenuation curves and dual-input perfusion CT experiments demonstrated that simultaneous dual input liver perfusion is feasible. Histologic analysis demonstrated that the hepatic microvasculature and architecture appeared intact and well preserved at the completion of four to six

  6. An evaluation of an initiative to improve Veterans Health Administration mental health services: broad impacts of the VHA's Mental Health Strategic Plan.

    PubMed

    Greenberg, Greg A; Rosenheck, Robert A

    2009-12-01

    In federal fiscal year (FY) 2005 the Department of Veterans Affairs (VA) implemented the comprehensive Mental Health Strategic Plan (MHSP). This study used performance measures from six broad domains to examine changes in the overall delivery of mental health services in the VA since the implementation of the MHSP. Performance measures from fiscal year 2004, the year before implementation of the MHSP, were compared with measures from fiscal years 2005, 2006, and 2007, the first 3 years of MHSP implementation. We combined heterogeneous performance measures within domains through the use of standardized scores or "z-scores." An overall improvement of 0.32 standardized units was observed from FY 2004 to FY 2007, representing moderate to large changes by conventional standards. The domains with the greatest improvement (>1.0 standard deviation units) from FY 2004 to FY 2007 were population coverage/access, outpatient care quality, economic performance (primarily efficiency), and global functioning. There was a 0.3 standard deviation decline in inpatient satisfaction and a slight increase in reliance on inpatient care. Overall improvement in VA mental health care was thus substantial and continuing.

  7. Embodying Computational Thinking: Initial Design of an Emerging Technological Learning Tool

    ERIC Educational Resources Information Center

    Daily, Shaundra B.; Leonard, Alison E.; Jörg, Sophie; Babu, Sabarish; Gundersen, Kara; Parmar, Dhaval

    2015-01-01

    This emerging technology report describes virtual environment interactions an approach for blending movement and computer programming as an embodied way to support girls in building computational thinking skills. The authors seek to understand how body syntonicity might enable young learners to bootstrap their intuitive knowledge in order to…

  8. Encouraging More Women into Computer Science: Initiating a Single-Sex Intervention Program in Sweden.

    ERIC Educational Resources Information Center

    Brandell, Gerd; Carlsson, Svante; Eklbom, Hakan; Nord, Ann-Charlotte

    1997-01-01

    Describes the process of starting a new program in computer science and engineering that is heavily based on applied mathematics and only open to women. Emphasizes that success requires considerable interest in mathematics and curiosity about computer science among female students at the secondary level and the acceptance of the single-sex program…

  9. Embodying Computational Thinking: Initial Design of an Emerging Technological Learning Tool

    ERIC Educational Resources Information Center

    Daily, Shaundra B.; Leonard, Alison E.; Jörg, Sophie; Babu, Sabarish; Gundersen, Kara; Parmar, Dhaval

    2015-01-01

    This emerging technology report describes virtual environment interactions an approach for blending movement and computer programming as an embodied way to support girls in building computational thinking skills. The authors seek to understand how body syntonicity might enable young learners to bootstrap their intuitive knowledge in order to…

  10. Using the Computer at Work. Project Visions2: Learning for Life Initiative.

    ERIC Educational Resources Information Center

    Taylor, Mary Lou, Comp.

    These materials were developed for a 20-hour class on computers in a cement manufacturing plant. (In the workplace, they were used in conjunction with Typing Tutor 6 software.) The course is intended for complete beginners who need to use computers on the job. Each of the four modules can be used alone. The document begins with a pretest and…

  11. Project IMPACT: Computer-Administered Instruction Concepts and Initial Development. Technical Report 69-3.

    ERIC Educational Resources Information Center

    Seidel, Robert J.

    This report summarizes Project IMPACT activities in fiscal year 1968. The goal of the project is to develop a computer-assisted instruction (CAI) training system in the COBOL language for the U.S. Army. Following an introduction, the report explains the instructional decision model which is used with an interactive computer system. The hardware…

  12. The impact of the U.S. supercomputing initiative will be global

    SciTech Connect

    Crawford, Dona

    2016-01-15

    Last July, President Obama issued an executive order that created a coordinated federal strategy for HPC research, development, and deployment called the U.S. National Strategic Computing Initiative (NSCI). However, this bold, necessary step toward building the next generation of supercomputers has inaugurated a new era for U.S. high performance computing (HPC).

  13. Initial Investigation of the relation between extended computer use and temporomandibular joint disorders.

    PubMed

    Perri, Romina; Huta, Veronika; Pinchuk, Leonard; Pinchuk, Cindy; Ostry, David J; Lund, James P

    2008-09-01

    To determine if temporomandibular joint disorders (TMDs) are associated with extended computer use. People with chronic pain and extensive computer use were recruited by means of a newspaper advertisement. Those who responded to the ad were asked to complete an online survey, which included questions on computer use, medical history, pain symptoms, lifestyle and mood. Ninety-two people completed the online survey, but none of them responded to all questions in the survey. Of the 88 respondents who reported their sex, 49 (56%) were female. Most of the respondents had used computers for more than 5 hours per day for more than 5 years, and most believed that their pain was linked to computer use. The great majority had pain in the neck (73/89 [82%]) or shoulder (67/89 [75%]), but many (40/91 [44%]) also had symptoms of TMD. About half of the participants reported poor sleep and fatigue, and many linked their pain to negative effects on lifestyle and poor quality of life. Two multiple regressions, with duration of pain as the dependent variable, were carried out, one using the entire sample of respondents who had completed the necessary sections of the survey (n = 91) and the other using the subset of people with symptoms suggestive of TMD (n = 40). Duration of computer use was associated with duration of pain in both analyses, but 6 other independent variables (injury or arthritis, hours of daily computer use, stress, position of computer screen relative to the eyes, sex, and age) were without effect. In these regression analyses, the intercept was close to 0 years, which suggests that the pain began at about the same time as computer use. This web-based survey provides the first evidence that chronic pain in jaw muscles and other symptoms of TMD are associated with long-term, heavy use of computers. However, the great majority of people with these symptoms probably also suffer from pain in the shoulder and neck.

  14. Strategic Planning: What's so Strategic about It?

    ERIC Educational Resources Information Center

    Strong, Bart

    2005-01-01

    The words "strategic" and "planning" used together can lead to confusion unless one spent the early years of his career in never-ending, team-oriented, corporate training sessions. Doesn't "strategic" have something to do with extremely accurate bombing or a defensive missile system or Star Wars or something? Don't "strategic" and "planning" both…

  15. Computer-Based Data Used To Support a College's Minority Education Initiative.

    ERIC Educational Resources Information Center

    Roberts, Charlie D.; And Others

    The Minority Education Initiative (MEI) was developed and implemented at Mott Community College to support minority academic success. The initiative included student and faculty recruitment, multicultural enrichment, support services, and articulation with other educational institutions and businesses. Objectives of the MEI were to increase the…

  16. Implementation and Effects of One-to-One Computing Initiatives: A Research Synthesis

    ERIC Educational Resources Information Center

    Penuel, William R.

    2006-01-01

    There are now a large number of initiatives designed to make laptops with wireless connectivity available to all students in schools. This paper synthesizes findings from research and evaluation studies that analyzed implementation and effects of one-to-one initiatives from a range of countries. Factors related to successful implementation…

  17. Strategic implementation plan

    NASA Technical Reports Server (NTRS)

    1989-01-01

    The Life Science Division of the NASA Office of Space Science and Applications (OSSA) describes its plans for assuring the health, safety, and productivity of astronauts in space, and its plans for acquiring further fundamental scientific knowledge concerning space life sciences. This strategic implementation plan details OSSA's goals, objectives, and planned initiatives. The following areas of interest are identified: operational medicine; biomedical research; space biology; exobiology; biospheric research; controlled ecological life support; flight programs and advance technology development; the life sciences educational program; and earth benefits from space life sciences.

  18. Restructuring Education: Strategic Options Required for Excellence. Conference Edition, Revised.

    ERIC Educational Resources Information Center

    Hennes, James, Ed.; Larsh, Jane, Ed.

    Strategic options for school restructuring are examined in this guidebook for Colorado educators and citizens networking in the Colorado Strategic Options Initiative. The authors are members of a group of state educators participating in the Strategic Options Network, a collaborative organization working to share research and results of their…

  19. An initial investigation into methods of computing transonic aerodynamic sensitivity coefficients

    NASA Technical Reports Server (NTRS)

    Carlson, Leland A.

    1992-01-01

    Research conducted during the period from July 1991 through December 1992 is covered. A method based upon the quasi-analytical approach was developed for computing the aerodynamic sensitivity coefficients of three dimensional wings in transonic and subsonic flow. In addition, the method computes for comparison purposes the aerodynamic sensitivity coefficients using the finite difference approach. The accuracy and validity of the methods are currently under investigation.

  20. Powerful Metrics: Strategic and Transformative

    ERIC Educational Resources Information Center

    Butterfield, Barbara

    2006-01-01

    To be a valuable partner at the strategic level, human resources can and should contribute to both institutional effectiveness measurement and workforce metrics. In this article, the author examines how to link HR initiatives with key institutional strategies, clarifies essential HR responsibilities for workforce results, explores return on human…

  1. Strategic Plan for Information Technology.

    ERIC Educational Resources Information Center

    Hudson County Community Coll., Jersey City, NJ.

    This report outlines the Hudson County Community College (HCCC) June 1998 Strategic Plan for Information Technology. After providing a list of planning committee members and an executive summary, the introduction provides background information concerning the creation of the information technology initiative. It also provides the objectives of…

  2. Joint Force Pre-Deployment Training: An Initial Analysis and Product Definition (Strategic Mobility 21: IT Planning Document for APS Demonstration Document (Task 3.7)

    DTIC Science & Technology

    2010-04-13

    pre-deployment training program “living design” first documented in 1995 and periodically updated over the past fifteen years. The report updates the...education and training. This report updates an advanced Joint force pre-deployment training program “living design” first documented in 1995 and...26 DEVELOPMENT OF THE FIRST COMPUTER BASED

  3. Use of a Computer-Aided Diagnosis System Aboard Patrolling FBM Submarines: Initial At-Sea Trials

    DTIC Science & Technology

    1981-04-29

    required a narcotic analgesic and the corpsmen was considering a diagnosis of small bowel obstruction , Datasheets, computer, printouts...analgesic on one occasion. The corpsman’s initial diagnosis was "possible small bowel obstruction ", a condition which could require surgery and...a 46% chance of appendicitis, 30% NSAP, and 22% small bowel obstruction . This was done the first day right after I gave him the Dukolax. Q

  4. An Analysis of Computer Aided Design (CAD) Packages Used at MSFC for the Recent Initiative to Integrate Engineering Activities

    NASA Technical Reports Server (NTRS)

    Smith, Leigh M.; Parker, Nelson C. (Technical Monitor)

    2002-01-01

    This paper analyzes the use of Computer Aided Design (CAD) packages at NASA's Marshall Space Flight Center (MSFC). It examines the effectiveness of recent efforts to standardize CAD practices across MSFC engineering activities. An assessment of the roles played by management, designers, analysts, and manufacturers in this initiative will be explored. Finally, solutions are presented for better integration of CAD across MSFC in the future.

  5. Intro - High Performance Computing for 2015 HPC Annual Report

    SciTech Connect

    Klitsner, Tom

    2015-10-01

    The recent Executive Order creating the National Strategic Computing Initiative (NSCI) recognizes the value of high performance computing for economic competitiveness and scientific discovery and commits to accelerate delivery of exascale computing. The HPC programs at Sandia –the NNSA ASC program and Sandia’s Institutional HPC Program– are focused on ensuring that Sandia has the resources necessary to deliver computation in the national interest.

  6. A new DoD initiative: the Computational Research and Engineering Acquisition Tools and Environments (CREATE) program

    NASA Astrophysics Data System (ADS)

    Arevalo, S.; Atwood, C.; Bell, P.; Blacker, T. D.; Dey, S.; Fisher, D.; Fisher, D. A.; Genalis, P.; Gorski, J.; Harris, A.; Hill, K.; Hurwitz, M.; Kendall, R. P.; Meakin, R. L.; Morton, S.; Moyer, E. T.; Post, D. E.; Strawn, R.; Veldhuizen, D. v.; Votta, L. G.; Wynn, S.; Zelinski, G.

    2008-07-01

    In FY2008, the U.S. Department of Defense (DoD) initiated the Computational Research and Engineering Acquisition Tools and Environments (CREATE) program, a 360M program with a two-year planning phase and a ten-year execution phase. CREATE will develop and deploy three computational engineering tool sets for DoD acquisition programs to use to design aircraft, ships and radio-frequency antennas. The planning and execution of CREATE are based on the 'lessons learned' from case studies of large-scale computational science and engineering projects. The case studies stress the importance of a stable, close-knit development team; a focus on customer needs and requirements; verification and validation; flexible and agile planning, management, and development processes; risk management; realistic schedules and resource levels; balanced short- and long-term goals and deliverables; and stable, long-term support by the program sponsor. Since it began in FY2008, the CREATE program has built a team and project structure, developed requirements and begun validating them, identified candidate products, established initial connections with the acquisition programs, begun detailed project planning and development, and generated the initial collaboration infrastructure necessary for success by its multi-institutional, multidisciplinary teams.

  7. A Simple Example of an SADMT (SDI-Strategic Defense Initiative) Architecture Dataflow Modeling Technique) Architecture Specification. Version 1.5.

    DTIC Science & Technology

    1988-04-21

    and receive messages via SADMT cones. The Ground..Staton... Communicaton ..TM transmits orders from the Command-Post and receives sensor data from the...Manager, Ada Technology Operating Center Syscon Corporation ".. 3990 Sherman St. San Diego, CA 92110 Dr. James C. Browne Computation Center Department of...90406 Teledyne Brown Engineering 3700 Pender Dr. Fairfax, VA 22030 Tom Cashion CALSPAN Corporation P.O. Box 9X Lexington, MA 02123 Virginia Castor

  8. Strategic materials availability and supply

    NASA Technical Reports Server (NTRS)

    Stephens, Joseph R.

    1989-01-01

    An evaluation is made of the supply sources and current availability of elements involved in superalloy compositions, as well as of development trends in the substitution of strategic materials for superalloys, giving attention to the results thus far achieved by NASA's Conservation of Strategic Aerospace Materials program, which formally operated only from 1980 to 1984 but whose various research initiatives have been continued under other NASA programs. Peacetime and wartime economies' need and probable availability analyses are presented for bauxite/aluminum, the Pt-group metals, and the alloying elements Mn, Nb, Ta, Co, Cr, Ni, W, Fe, Cu, Ti, Mo, and Mg.

  9. Encouraging more women into computer science: Initiating a single-sex intervention program in Sweden

    NASA Astrophysics Data System (ADS)

    Brandell, Gerd; Carlsson, Svante; Ekblom, Håkan; Nord, Ann-Charlotte

    1997-11-01

    The process of starting a new program in computer science and engineering, heavily based on applied mathematics and only open to women, is described in this paper. The program was introduced into an educational system without any tradition in single-sex education. Important observations made during the process included the considerable interest in mathematics and curiosity about computer science found among female students at the secondary school level, and the acceptance of the single-sex program by the staff, administration, and management of the university as well as among male and female students. The process described highlights the importance of preparing the environment for a totally new type of educational program.

  10. Strategic Sourcing in the Army

    DTIC Science & Technology

    2013-09-01

    sector:  Total Cost of Ownership tools are applied to understand the life cycle costs of a product or service  Supplier Scorecards to apply a...sourcing efforts, as well as prioritizing new initiatives. In addition to cost and performance goals, any strategic sourcing plan must be balanced with...article/97687/ 39 INITIAL DISTRIBUTION LIST 1. Defense Technical Information Center Ft. Belvoir, Virginia 2. Dudley Knox Library Naval Postgraduate School Monterey, California

  11. A comparison on initial-value ray tracing and fast marching eikonal solver for VTI traveltime computing

    NASA Astrophysics Data System (ADS)

    Moussavi Alashloo, S. Y.; Ghosh, D. P.; Bashir, Y.; Yusoff, W. I. Wan

    2016-02-01

    The Earth's subsurface is an anisotropic medium where the velocity of seismic waves alters in different propagation angles. Omitting anisotropy in seismic imaging not only brings mis-positioning of migrated dipping events but also fails to retain dipping energy during dip-moveout. To account for the efficacy of seismic anisotropy in imaging, an anisotropic wave equation must be engaged. Seismic traveltime computing is fundamental of both Kirchhoff migration and tomography algorithms. Two main categories of traveltime computing involve traditional ray tracing methods and finite difference eikonal solvers. In this study, we present two techniques of initial-value ray tracing and fast marching eikonal solver in isotropic and vertical transverse isotropy (VTI) media, and a comparison between results is demonstrated for more evaluation. Although the ray tracing approach is able to compute multiple arrivals with great precision, the eikonal solver is faster and more robust for traveltime computation. Since the ray tracing result is not a deterministic solution and it depends on the initial circumstance, employing the eikonal solver method are more preferred and suggested.

  12. The Strategic Communication Plan: Effective Communication for Strategic Leaders.

    DTIC Science & Technology

    2007-11-02

    PLAN? 5 WHO SHOULD HAVE A STRATEGIC COMMUNICATIONS PLAN? 7 SUCCESSFUL STRATEGIC PLANNING BEGINS WITH STRATEGIC THINKING . 8 HOW IS THE STRATEGIC...communicate internally and externally.9 SUCCESSFUL STRATEGIC PLANNING BEGINS WITH STRATEGIC THINKING A key objective of strategic thinking is to formulate and...vision should be captured in the strategic communication plan. Yet, in many organizations, prescribed strategic planning systems are the death knell

  13. Initial Comparison of Single Cylinder Stirling Engine Computer Model Predictions with Test Results

    NASA Technical Reports Server (NTRS)

    Tew, R. C., Jr.; Thieme, L. G.; Miao, D.

    1979-01-01

    A Stirling engine digital computer model developed at NASA Lewis Research Center was configured to predict the performance of the GPU-3 single-cylinder rhombic drive engine. Revisions to the basic equations and assumptions are discussed. Model predictions with the early results of the Lewis Research Center GPU-3 tests are compared.

  14. Computer Abuse and Misuse: An Assessment of Federal and State Legislative Initiatives.

    DTIC Science & Technology

    1984-12-01

    technical safeguards, such as poor management of passwords or lack of encryption ; proliferation of computers, especially those accessible by networks...security tools. Innovations, such as commercially available encryption devices, reportedly, are not being universally used. A Unfortunately...NATIONAL POLICY ON TELECOMMUNICATIONS AND AUTOMATED INFORMATION SYSTEMS SECURITY 6t p NSD Directive 145 (Unclassified Version) 4~ S li " - . . .. THE WHITE

  15. High Performance Parallel Processing Project: Industrial computing initiative. Progress reports for fiscal year 1995

    SciTech Connect

    Koniges, A.

    1996-02-09

    This project is a package of 11 individual CRADA`s plus hardware. This innovative project established a three-year multi-party collaboration that is significantly accelerating the availability of commercial massively parallel processing computing software technology to U.S. government, academic, and industrial end-users. This report contains individual presentations from nine principal investigators along with overall program information.

  16. Language Acquisition as Computational Resetting: Verb Movement in L3 Initial State

    ERIC Educational Resources Information Center

    Hermas, Abdelkader

    2010-01-01

    This study considers the acquisition of the verb movement parameter in L3 English by adult Arabic-French bilinguals. The focus is on the nature of the L3 initial state and the contribution of the syntactic (C[subscript HL]) and post-syntactic (phonetic form) modules to the process of parameter resetting. The results of acceptability judgement…

  17. Computational simulation of surface waviness in graphite/epoxy woven composites due to initial curing

    NASA Technical Reports Server (NTRS)

    Sanfeliz, Jose G.; Murthy, Pappu L. N.; Chamis, Christos C.

    1992-01-01

    Several models simulating plain weave, graphite/epoxy woven composites are presented, along with the effects that the simultaneous application of pressure and thermal loads have on their surfaces. The surface effects created by moisture absorption are also examined. The computational simulation consisted of using a two-dimensional finite element model for the composite. The properties of the finite element (FE) model are calculated by using the in-house composite mechanics computer code ICAN (Integrated Composite ANalyzer). MSC/NASTRAN is used for the FE analysis which yields the composite's top surface normalized displacements. These results demonstrate the importance of parameters such as the cure temperature (T sub o) and the resin content in the curing process of polymer-matrix composites. The modification of these parameters will help tailor the composite system to the desired requirements and applications.

  18. Computational simulation of surface waviness in graphite/epoxy woven composites due to initial curing

    NASA Technical Reports Server (NTRS)

    Sanfeliz, Jose G.; Murthy, Pappu L. N.; Chamis, Christos C.

    1992-01-01

    Several models simulating plain weave, graphite/epoxy woven composites are presented, along with the effects that the simultaneous application of pressure and thermal loads have on their surfaces. The surface effects created by moisture absorption are also examined. The computational simulation consisted of using a two-dimensional finite element model for the composite. The properties of the finite element (FE) model are calculated by using the in-house composite mechanics computer code ICAN (Integrated Composite ANalyzer). MSC/NASTRAN is used for the FE analysis which yields the composite's top surface normalized displacements. These results demonstrate the importance of parameters such as the cure temperature (T sub o) and the resin content in the curing process of polymer-matrix composites. The modification of these parameters will help tailor the composite system to the desired requirements and applications.

  19. The case for computed tomographic angiography for initial management of lower gastrointestinal hemorrhage

    PubMed Central

    Cura, Marco

    2017-01-01

    Lower gastrointestinal hemorrhage remains a common disease, frequently presenting with acute life-threatening symptoms. Although prompt detection and treatment are imperative, it is difficult to diagnose lower gastrointestinal hemorrhage in an accurate and efficient manner. Most available modalities are time consuming. Computed tomographic angiography of the abdomen and pelvis, on the other hand, has the unique capability of rapidly detecting whether life-threatening hemorrhage is occurring and accurately localizing it, thus facilitating definitive treatment. We present a case in which computed tomographic angiography was invaluable in the detection and subsequent empirical transarterial embolization of a lower gastrointestinal hemorrhage and offer evidence as to why it should be a first-line tool in the management of these patients. PMID:28670085

  20. The case for computed tomographic angiography for initial management of lower gastrointestinal hemorrhage.

    PubMed

    Gupton, Theodore; Cura, Marco

    2017-07-01

    Lower gastrointestinal hemorrhage remains a common disease, frequently presenting with acute life-threatening symptoms. Although prompt detection and treatment are imperative, it is difficult to diagnose lower gastrointestinal hemorrhage in an accurate and efficient manner. Most available modalities are time consuming. Computed tomographic angiography of the abdomen and pelvis, on the other hand, has the unique capability of rapidly detecting whether life-threatening hemorrhage is occurring and accurately localizing it, thus facilitating definitive treatment. We present a case in which computed tomographic angiography was invaluable in the detection and subsequent empirical transarterial embolization of a lower gastrointestinal hemorrhage and offer evidence as to why it should be a first-line tool in the management of these patients.

  1. A High Resolution, Three-Dimensional, Computationally Efficient, Diagnostic Wind Model: Initial Development Report

    DTIC Science & Technology

    2003-10-01

    reasonably accurate in representing the flow physics and computationally efficient. The basic framework of the model is discussed in this document... Basically , this version of the model takes about 20 to 30 times more CPU time to 17 run, compared with the latest model version implemented with the...free or surface-mounted obstacles: applying topology to flow visulization . J. Fluid Mech. 1978, 86, pp 179-200. Kastner-Klein, P.; Rotach, M. W

  2. Strategic Material Supply Mitigation Initiatives within DLA - Strategic Materials

    DTIC Science & Technology

    2012-05-24

    engine with afterburner as used in the F-105B Thunderchief This is a Pratt & Whitney PW4084 turbofan Refractory metal alloys include Rhenium...recovery) – Life cycling modeling – Predictive Means to Evaluate Multiple Failure Modes • Material(s) Identification – Multi-tiered Supply Chain...process analysis and roadmaps (WSS) R&D Challenge: • Automated capture of commercial and engineering data into the Federal Logistics Information

  3. Integrated Computational Materials Engineering of Titanium: Current Capabilities Being Developed Under the Metals Affordability Initiative

    NASA Astrophysics Data System (ADS)

    Glavicic, M. G.; Venkatesh, V.

    2014-07-01

    A technical review of the titanium model development programs currently funded under the Metals Affordability Initiative is presented. Progress of the "Advanced Titanium Alloy Microstructure and Mechanical Property Modeling" and "ICME of Microtexture Evolution and its Effect on Cold Dwell/High/Low Cycle Fatigue Behavior of Dual Phase Titanium Alloys" will be reviewed followed by a discussion of the future modeling needs of the aerospace industry.

  4. An implicit steady-state initialization package for the RELAP5 computer code

    SciTech Connect

    Paulsen, M.P.; Peterson, C.E.; Odar, F.

    1995-08-01

    A direct steady-state initialization (DSSI) method has been developed and implemented in the RELAP5 hydrodynamic analysis program. It provides a means for users to specify a small set of initial conditions which are then propagated through the remainder of the system. The DSSI scheme utilizes the steady-state form of the RELAP5 balance equations for nonequilibrium two-phase flow. It also employs the RELAP5 component models and constitutive model packages for wall-to-phase and interphase momentum and heat exchange. A fully implicit solution of the linearized hydrodynamic equations is implemented. An implicit coupling scheme is used to augment the standard steady-state heat conduction solution for steam generator use. It solves the primary-side tube region energy equations, heat conduction equations, wall heat flux boundary conditions, and overall energy balance equation as a coupled system of equations and improves convergence. The DSSI method for initializing RELAP5 problems to steady-state conditions has been compared with the transient solution scheme using a suite of test problems including; adiabatic single-phase liquid and vapor flow through channels with and without healing and area changes; a heated two-phase test bundle representative of BWR core conditions; and a single-loop PWR model.

  5. Initial analysis of SAR from a cell phone inside a vehicle by numerical computation.

    PubMed

    Anzaldi, Gabriel; Silva, Ferran; Fernández, Mireya; Quílez, Marcos; Riu, Pere J

    2007-05-01

    The purpose of this paper is to analyze the influence of the metallic structures of a realistic car body frame on the specific absorption rate (SAR) produced by a cell phone when a complete human body model is placed at different locations inside the vehicle, and to identify the relevant parameters responsible for these changes. The modeling and analysis of the whole system was conducted by means of computer simulations based on the full wave finite-difference time-domain (FDTD) numerical method. The excitation considered was an 835 MHz lambda/2 dipole located as a hands-free communication device or as a hand-held portable system. We compared the SAR at different planes on the human model, placed inside the vehicle with respect to the free space situation. The presence of the car body frame significantly changes the SAR distributions, especially when the dipole is far from the body. Although the results are not conclusive on this point, this change in SAR distribution is not likely to produce an increase above the limits in current guidelines for partial body exposure, but may be significant for whole-body exposure. The most relevant change found was the change in the impedance of the dipole, affecting the radiated power. A complementary result from the electromagnetic computations performed is the change in the electromagnetic field distribution inside a vehicle when human bodies are present. The whole vehicle model has been optimized to provide accurate results for sources placed inside the vehicle, while keeping low requirements for computer storage and simulation time.

  6. The Computer-Vision Symptom Scale (CVSS17): development and initial validation.

    PubMed

    González-Pérez, Mariano; Susi, Rosario; Antona, Beatriz; Barrio, Ana; González, Enrique

    2014-06-17

    To develop a questionnaire (in Spanish) to measure computer-related visual and ocular symptoms (CRVOS). A pilot questionnaire was created by consulting the literature, clinicians, and video display terminal (VDT) workers. The replies of 636 subjects completing the questionnaire were assessed using the Rasch model and conventional statistics to generate a new scale, designated the Computer-Vision Symptom Scale (CVSS17). Validity and reliability were determined by Rasch fit statistics, principal components analysis (PCA), person separation, differential item functioning (DIF), and item-person targeting. To assess construct validity, the CVSS17 was correlated with a Rasch-based visual discomfort scale (VDS) in 163 VDT workers, this group completed the CVSS17 twice in order to assess test-retest reliability (two-way single-measure intraclass correlation coefficient [ICC] and their 95% confidence intervals, and the coefficient of repeatability [COR]). The CVSS17 contains 17 items exploring 15 different symptoms. These items showed good reliability and internal consistency (mean square infit and outfit 0.88-1.17, eigenvalue for the first residual PCA component 1.37, person separation 2.85, and no DIF). Pearson's correlation with VDS scores was 0.60 (P < 0.001). Intraclass correlation coefficient for test-retest reliability was 0.849 (95% confidence interval [CI], 0.800-0.887), and COR was 8.14. The Rasch-based linear-scale CVSS17 emerged as a useful tool to quantify CRVOS in computer workers. : Spanish Abstract. Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.

  7. Strategic Supply

    DTIC Science & Technology

    2003-01-01

    Peoria IL CSC Defense Group, Falls Church VA DHL Danzas Air and Ocean, Washington DC Defense Logistics Agency, Ft. Belvoir VA Dell Computer...before October 2002, Danzas /DHL had 18 regional data centers and a huge number of servers. They consolidated all data into one center in Tempe, Arizona

  8. Computer simulation of initial events in the biochemical mechanisms of DNA damage

    NASA Technical Reports Server (NTRS)

    Chatterjee, A.; Holley, W. R.

    1993-01-01

    Understanding the systematic and quantitative correlation between the physical events of energy deposition by ionizing radiation and the ensuing chemical and biochemical processes leading to DNA damage is one of the goals in radiation research. Significant progress has been made toward achieving the stated goal by using theoretical modeling techniques. These techniques are strongly dependent on computer simulation procedures. A review of such techniques with details of various stages of simulation development, including a comparison with available experimental data, is presented in this article.

  9. An initial investigation into methods of computing transonic aerodynamic sensitivity coefficients

    NASA Technical Reports Server (NTRS)

    Carlson, Leland A.

    1991-01-01

    The three dimensional quasi-analytical sensitivity analysis and the ancillary driver programs are developed needed to carry out the studies and perform comparisons. The code is essentially contained in one unified package which includes the following: (1) a three dimensional transonic wing analysis program (ZEBRA); (2) a quasi-analytical portion which determines the matrix elements in the quasi-analytical equations; (3) a method for computing the sensitivity coefficients from the resulting quasi-analytical equations; (4) a package to determine for comparison purposes sensitivity coefficients via the finite difference approach; and (5) a graphics package.

  10. Computed tomography, lymphography, and staging laparotomy: correlations in initial staging of Hodgkin disease

    SciTech Connect

    Castellino, R.A.; Hoppe, R.T.; Blank, N.; Young, S.W.; Neumann, C.; Rosenberg, S.A.; Kaplan, H.S.

    1984-07-01

    One hundred twenty-one patients with newly diagnosed, previously untreated Hodgkin disease underwent abdominal and pelvic computed tomographic (CT) scanning and bipedal lymphography. These studies were followed by staging laparotomy, which included biopsy of the liver, retroperitoneal and mesenteric lymph nodes, and splenectomy. Correlation of the results of the imaging studies with the histopathologic diagnoses revealed a small - but significant - increased accuracy of lymphography compared with CT in assessing the retroperitoneal lymph nodes. The theoretical advantages of CT scanning in detecting lymphomatous deposits in lymph nodes about the celiac axis and the mesentery, or in the liver and spleen, were not confirmed.

  11. Computer simulation of initial events in the biochemical mechanisms of DNA damage

    NASA Technical Reports Server (NTRS)

    Chatterjee, A.; Holley, W. R.

    1993-01-01

    Understanding the systematic and quantitative correlation between the physical events of energy deposition by ionizing radiation and the ensuing chemical and biochemical processes leading to DNA damage is one of the goals in radiation research. Significant progress has been made toward achieving the stated goal by using theoretical modeling techniques. These techniques are strongly dependent on computer simulation procedures. A review of such techniques with details of various stages of simulation development, including a comparison with available experimental data, is presented in this article.

  12. [Materials management system in interventional radiology -- initial experience with a computer-supported program].

    PubMed

    Clevert, D-A; Jung, E M; Reiser, M; Rupp, N

    2004-10-01

    To perform a cost analysis for assessing options of reorganizing material supplies and reducing costs of the radiology division through the introduction of a materials management system. A materials management system (Piranha, Boston Scientific) was installed on an existing computer system. All consumables were inventoried and entered into the system. An ABC analysis determined further action. On the basis of order frequencies and availability requirements for emergencies, safety levels were agreed with physicians and other medical staff. Inventory costs were computed using these data. The interest rate for the capital tied up in the inventory was 8 % per year. The inventory showed that the capital tied up in stocks was euro 260,000 in 2001 and euro 190,000 in 2002. A change in supply strategy reduced inventory cost in 2001 and 2002. Annual interest expense was lowered by euro 18,420. Another saving of euro 2,700 was achieved by a reduction in storage cost. Annual inventory turnover totaled euro 298,000. The total cost cut through improved inventory management was euro 21,120 per year, which is equivalent to 7 % of the annual expenses. Adding the decline in the cost of shelf time overruns equal to 5 % of the annual expenses, the saving was approximately 12 % of total interventional radiology cost in 2001 and some 11 % in 2002. Flexible supply strategies and the introduction of a materials management program can help to reduce inventory costs in interventional radiology divisions without any impact on service levels.

  13. COMPASS, the COMmunity Petascale Project for Accelerator Science And Simulation, a Broad Computational Accelerator Physics Initiative

    SciTech Connect

    Cary, J.R.; Spentzouris, P.; Amundson, J.; McInnes, L.; Borland, M.; Mustapha, B.; Norris, B.; Ostroumov, P.; Wang, Y.; Fischer, W.; Fedotov, A.; Ben-Zvi, I.; Ryne, R.; Esarey, E.; Geddes, C.; Qiang, J.; Ng, E.; Li, S.; Ng, C.; Lee, R.; Merminga, L.; /Jefferson Lab /Tech-X, Boulder /UCLA /Colorado U. /Maryland U. /Southern California U.

    2007-11-09

    Accelerators are the largest and most costly scientific instruments of the Department of Energy, with uses across a broad range of science, including colliders for particle physics and nuclear science and light sources and neutron sources for materials studies. COMPASS, the Community Petascale Project for Accelerator Science and Simulation, is a broad, four-office (HEP, NP, BES, ASCR) effort to develop computational tools for the prediction and performance enhancement of accelerators. The tools being developed can be used to predict the dynamics of beams in the presence of optical elements and space charge forces, the calculation of electromagnetic modes and wake fields of cavities, the cooling induced by comoving beams, and the acceleration of beams by intense fields in plasmas generated by beams or lasers. In SciDAC-1, the computational tools had multiple successes in predicting the dynamics of beams and beam generation. In SciDAC-2 these tools will be petascale enabled to allow the inclusion of an unprecedented level of physics for detailed prediction.

  14. COMPASS, the COMmunity Petascale project for Accelerator Science and Simulation, a board computational accelerator physics initiative

    SciTech Connect

    Cary, J.R.; Spentzouris, P.; Amundson, J.; McInnes, L.; Borland, M.; Mustapha, B.; Ostroumov, P.; Wang, Y.; Fischer, W.; Fedotov, A.; Ben-Zvi, I.; Ryne, R.; Esarey, E.; Geddes, C.; Qiang, J.; Ng, E.; Li, S.; Ng, C.; Lee, R.; Merminga, L.; Wang, H.; Bruhwiler, D.L.; Dechow, D.; Mullowney, P.; Messmer, P.; Nieter, C.; Ovtchinnikov, S.; Paul, K.; Stoltz, P.; Wade-Stein, D.; Mori, W.B.; Decyk, V.; Huang, C.K.; Lu, W.; Tzoufras, M.; Tsung, F.; Zhou, M.; Werner, G.R.; Antonsen, T.; Katsouleas, T.; Morris, B.

    2007-07-16

    Accelerators are the largest and most costly scientific instruments of the Department of Energy, with uses across a broad range of science, including colliders for particle physics and nuclear science and light sources and neutron sources for materials studies. COMPASS, the Community Petascale Project for Accelerator Science and Simulation, is a broad, four-office (HEP, NP, BES, ASCR) effort to develop computational tools for the prediction and performance enhancement of accelerators. The tools being developed can be used to predict the dynamics of beams in the presence of optical elements and space charge forces, the calculation of electromagnetic modes and wake fields of cavities, the cooling induced by comoving beams, and the acceleration of beams by intense fields in plasmas generated by beams or lasers. In SciDAC-1, the computational tools had multiple successes in predicting the dynamics of beams and beam generation. In SciDAC-2 these tools will be petascale enabled to allow the inclusion of an unprecedented level of physics for detailed prediction.

  15. COMPASS, the COMmunity Petascale Project for Accelerator Science and Simulation, a broad computational accelerator physics initiative

    SciTech Connect

    J.R. Cary; P. Spentzouris; J. Amundson; L. McInnes; M. Borland; B. Mustapha; B. Norris; P. Ostroumov; Y. Wang; W. Fischer; A. Fedotov; I. Ben-Zvi; R. Ryne; E. Esarey; C. Geddes; J. Qiang; E. Ng; S. Li; C. Ng; R. Lee; L. Merminga; H. Wang; D.L. Bruhwiler; D. Dechow; P. Mullowney; P. Messmer; C. Nieter; S. Ovtchinnikov; K. Paul; P. Stoltz; D. Wade-Stein; W.B. Mori; V. Decyk; C.K. Huang; W. Lu; M. Tzoufras; F. Tsung; M. Zhou; G.R. Werner; T. Antonsen; T. Katsouleas

    2007-06-01

    Accelerators are the largest and most costly scientific instruments of the Department of Energy, with uses across a broad range of science, including colliders for particle physics and nuclear science and light sources and neutron sources for materials studies. COMPASS, the Community Petascale Project for Accelerator Science and Simulation, is a broad, four-office (HEP, NP, BES, ASCR) effort to develop computational tools for the prediction and performance enhancement of accelerators. The tools being developed can be used to predict the dynamics of beams in the presence of optical elements and space charge forces, the calculation of electromagnetic modes and wake fields of cavities, the cooling induced by comoving beams, and the acceleration of beams by intense fields in plasmas generated by beams or lasers. In SciDAC-1, the computational tools had multiple successes in predicting the dynamics of beams and beam generation. In SciDAC-2 these tools will be petascale enabled to allow the inclusion of an unprecedented level of physics for detailed prediction.

  16. Computational modelling and analysis of the molecular network regulating sporulation initiation in Bacillus subtilis.

    PubMed

    Ihekwaba, Adaoha E C; Mura, Ivan; Barker, Gary C

    2014-10-24

    Bacterial spores are important contaminants in food, and the spore forming bacteria are often implicated in food safety and food quality considerations. Spore formation is a complex developmental process involving the expression of more than 500 genes over the course of 6 to 8 hrs. The process culminates in the formation of resting cells capable of resisting environmental extremes and remaining dormant for long periods of time, germinating when conditions promote further vegetative growth. Experimental observations of sporulation and germination are problematic and time consuming so that reliable models are an invaluable asset in terms of prediction and risk assessment. In this report we develop a model which assists in the interpretation of sporulation dynamics. This paper defines and analyses a mathematical model for the network regulating Bacillus subtilis sporulation initiation, from sensing of sporulation signals down to the activation of the early genes under control of the master regulator Spo0A. Our model summarises and extends other published modelling studies, by allowing the user to execute sporulation initiation in a scenario where Isopropyl β-D-1-thiogalactopyranoside (IPTG) is used as an artificial sporulation initiator as well as in modelling the induction of sporulation in wild-type cells. The analysis of the model results and the comparison with experimental data indicate that the model is good at predicting inducible responses to sporulation signals. However, the model is unable to reproduce experimentally observed accumulation of phosphorelay sporulation proteins in wild type B. subtilis. This model also highlights that the phosphorelay sub-component, which relays the signals detected by the sensor kinases to the master regulator Spo0A, is crucial in determining the response dynamics of the system. We show that there is a complex connectivity between the phosphorelay features and the master regulatory Spo0A. Additional we discovered that the

  17. A generalized computationally efficient inverse characterization approach combining direct inversion solution initialization with gradient-based optimization

    NASA Astrophysics Data System (ADS)

    Wang, Mengyu; Brigham, John C.

    2017-03-01

    A computationally efficient gradient-based optimization approach for inverse material characterization from incomplete system response measurements that can utilize a generally applicable parameterization (e.g., finite element-type parameterization) is presented and evaluated. The key to this inverse characterization algorithm is the use of a direct inversion strategy with Gappy proper orthogonal decomposition (POD) response field estimation to initialize the inverse solution estimate prior to gradient-based optimization. Gappy POD is used to estimate the complete (i.e., all components over the entire spatial domain) system response field from incomplete (e.g., partial spatial distribution) measurements obtained from some type of system testing along with some amount of a priori information regarding the potential distribution of the unknown material property. The estimated complete system response is used within a physics-based direct inversion procedure with a finite element-type parameterization to estimate the spatial distribution of the desired unknown material property with minimal computational expense. Then, this estimated spatial distribution of the unknown material property is used to initialize a gradient-based optimization approach, which uses the adjoint method for computationally efficient gradient calculations, to produce the final estimate of the material property distribution. The three-step [(1) Gappy POD, (2) direct inversion, and (3) gradient-based optimization] inverse characterization approach is evaluated through simulated test problems based on the characterization of elastic modulus distributions with localized variations (e.g., inclusions) within simple structures. Overall, this inverse characterization approach is shown to efficiently and consistently provide accurate inverse characterization estimates for material property distributions from incomplete response field measurements. Moreover, the solution procedure is shown to be capable

  18. LETTERS AND COMMENTS: Self-initiation of EEG-based brain computer communication using the heart rate response

    NASA Astrophysics Data System (ADS)

    Scherer, R.; Müller-Putz, G. R.; Pfurtscheller, G.

    2007-12-01

    Self-initiation, that is the ability of a brain-computer interface (BCI) user to autonomously switch on and off the system, is a very important issue. In this work we analyze whether the respiratory heart rate response, induced by brisk inspiration, can be used as an additional communication channel. After only 20 min of feedback training, ten healthy subjects were able to self-initiate and operate a 4-class steady-state visual evoked potential-based (SSVEP) BCI by using one bipolar ECG and one bipolar EEG channel only. Threshold detection was used to measure a beat-to-beat heart rate increase. Despite this simple method, during a 30 min evaluation period on average only 2.9 non-intentional switches (heart rate changes) were detected.

  19. Structural transformations at the initial stages of fragmentation of plastically deformed polycrystals: A computer experiment

    NASA Astrophysics Data System (ADS)

    Rybin, V. V.; Perevezentsev, V. N.; Svirina, Yu. V.

    2017-05-01

    Results have been presented for a computer experiment on concurrent micro-, meso-, and macroscopic studies of the evolution of dislocation structure in a large (adjacent to one of the junctions) domain of a grain after its constant-rate macroplastic deformation to an extent that corresponds to the onset of the stage of developed plastic deformation. The type of dislocation-density and dislocation-charge distributions, as well as amounts and degrees of inhomogeneity in local plastic deformation, have been analyzed. The type of dislocation rearrangements at the junctions and fractures of high-angle grain boundaries has been established, which is responsible for the formation of the first dangling dislocation boundaries, which are mesodefects that trigger fragmentation.

  20. The Cerec 3--a quantum leap for computer-aided restorations: initial clinical results.

    PubMed

    Mörmann, W H; Bindl, A

    2000-01-01

    The Cerec 3 system simplifies and accelerates the fabrication of ceramic inlays, onlays, veneers, and quarter, half, and complete crowns for anterior and posterior teeth. Cerec 3 software simplifies occlusal and functional registration. Proper occlusion is established accurately and quickly; manual adjustment is reduced to a minimum. The separate grinding device, working true to morphologic detail and with fine surface quality, is connected to the optical unit by radio control. Equipped with a laser scanner, it can also be used for indirect application through a standard personal computer. The Cerec 3 system is network and multimedia ready and, in combination with an intraoral color videocamera or a digital radiography unit, can be used for patient education and for user training. The Cerec 3 system thus is a diagnostic, restorative, training, and documentation center for the dental practice.

  1. Imageless computer-assisted versus conventional total hip arthroplasty: one surgeon's initial experience.

    PubMed

    Brown, Matthew L; Reed, Jeffrey D; Drinkwater, Christopher J

    2014-05-01

    Computer-assisted surgery (CAS) systems are advocated to improve component positioning in THA, though potential operative risks and costs of CAS have fueled debate. The present study examines the radiographic outcomes, operative efficiency, cost, and midterm functional outcomes for patients who underwent THA, either with CAS or conventional instrumentation. Patient baseline characteristics were recorded for 126 lower-extremities in the CAS series, and 215 in the conventional series. There was no difference in Harris Hip Score or leg length discrepancy between series. Inclination angle, blood loss, and operating room times were increased for CAS. These results suggest that CAS confers no advantage over conventional methods regarding accuracy of THA component placement, drives unreimbursed increases in procedure costs, may expose patients to additional operative risk, and produces no functional benefit at midterm follow-up. © 2014.

  2. Initial experience with distributing structural calculations among computers operating in parallel

    NASA Technical Reports Server (NTRS)

    Rogers, J. L., Jr.; Sobieszczanski-Sobieski, J.

    1984-01-01

    An existing program is currently being adapted to perform finite element analysis by distributing substructures over a network of four Apple IIe microcomputers connected to a shared disk. In this network, one microcomputer controls the entire process while the others perform the analysis on each substructure in parallel. This substructure analysis is used in an iterative, fully stressed, structural resizing procedure. This procedure allows experimentatation with resizing in which all analyses are not completed during a single iteration. This research gives some insight on how to configure multidiscriplinary analysis and optimization procedures for decomposable engineering systems using either high performance engineering workstations or a parallel processor supercomputer. In addition, the operational experience gained facilitates the implementation of analysis programs on these new computers when they become available in an engineering environment.

  3. Initial results of imaging melanoma metastasis in resected human lymph nodes using photoacoustic computed tomography

    NASA Astrophysics Data System (ADS)

    Jose, Jithin; Grootendorst, Diederik J.; Vijn, Thomas W.; Wouters, Michel W.; van Boven, Hester; van Leeuwen, Ton G.; Steenbergen, Wiendelt; Ruers, Theo J. M.; Manohar, Srirang

    2011-09-01

    The pathological status of the sentinel lymph node is important for accurate melanoma staging, ascertaining prognosis and planning treatment. The standard procedure involves biopsy of the node and histopathological assessment of its status. Drawbacks of this examination include a finite sampling of the node with the likelihood of missing metastases, and a significant time-lag before histopathological results are available to the surgeon. We studied the applicability of photoacoustic computed tomographic imaging as an intraoperative modality for examining the status of resected human sentinel lymph nodes. We first applied the technique to image ex vivo pig lymph nodes carrying metastases-simulating melanoma cells using multiple wavelengths. The experience gained was applied to image a suspect human lymph node. We validated the photoacoustic imaging results by comparing a reconstructed slice with a histopathological section through the node. Our results suggest that photoacoustics has the potential to develop into an intraoperative imaging method to detect melanoma metastases in sentinel lymph nodes.

  4. Hepatic ablation with multiple interstitial ultrasound applicators: initial ex vivo and computational studies

    NASA Astrophysics Data System (ADS)

    Prakash, Punit; Salgaonkar, Vasant A.; Burdette, E. Clif; Diederich, Chris J.

    2011-03-01

    Radiofrequency (RF) ablation has emerged as an effective method for treating liver tumors under 3 cm in diameter. Multiple applicator devices and techniques - using RF, microwave and other modalities - are under development for thermal ablation of large and irregularly-shaped liver tumors. Interstitial ultrasound (IUS) applicators, comprised of linear arrays of independently powered tubular transducers, enable 3D control of the spatial power deposition profile and simultaneous ablation with multiple applicators. We evaluated IUS applicator configurations (parallel, converging and diverging implants) suitable for percutaneous and laparascopic placement with experiments in ex vivo bovine tissue and computational models. Ex vivo ablation zones measured 4.6+/-0.5 x 4.2+/-0.5 × 3.3+/-0.5 cm3 and 5.6+/-0.5 × 4.9+/-0.5 x 2.8+/-0.3 cm3 using three parallel applicators spaced 2 and 3 cm apart, respectively, and 4.0+/-0.3 × 3.2+/-0.4 × 2.9+/-0.2 cm3 using two parallel applicators spaced 2 cm apart. Computational models indicate in vivo ablation zones up to 4.5 × 4.4 × 5.5 cm3 and 5.7 × 4.8 × 5.2 cm3, using three applicators spaced 2 and 3 cm apart, respectively. Converging and diverging implant patterns can also be employed for conformal ablation of irregularly-shaped tumor margins by tailoring power levels along each device. Simultaneously powered interstitial ultrasound devices can create tailored ablation zones comparable to currently available RF devices and similarly sized microwave antennas.

  5. Towards a Mathematical Formalism for Semi-stochastic Cell-Level Computational Modeling of Tumor Initiation.

    PubMed

    Vermolen, F J; Meijden, R P van der; Es, M van; Gefen, A; Weihs, D

    2015-07-01

    A phenomenological model is formulated to model the early stages of tumor formation. The model is based on a cell-based formalism, where each cell is represented as a circle or sphere in two-and three dimensional simulations, respectively. The model takes into account constituent cells, such as epithelial cells, tumor cells, and T-cells that chase the tumor cells and engulf them. Fundamental biological processes such as random walk, haptotaxis/chemotaxis, contact mechanics, cell proliferation and death, as well as secretion of chemokines are taken into account. The developed formalism is based on the representation of partial differential equations in terms of fundamental solutions, as well as on stochastic processes and stochastic differential equations. We also take into account the likelihood of seeding of tumors. The model shows the initiation of tumors and allows to study a quantification of the impact of various subprocesses and possibly even of various treatments.

  6. Entrainment to Periodic Initiation and Transition Rates in a Computational Model for Gene Translation

    PubMed Central

    Margaliot, Michael; Sontag, Eduardo D.; Tuller, Tamir

    2014-01-01

    Periodic oscillations play an important role in many biomedical systems. Proper functioning of biological systems that respond to periodic signals requires the ability to synchronize with the periodic excitation. For example, the sleep/wake cycle is a manifestation of an internal timing system that synchronizes to the solar day. In the terminology of systems theory, the biological system must entrain or phase-lock to the periodic excitation. Entrainment is also important in synthetic biology. For example, connecting several artificial biological systems that entrain to a common clock may lead to a well-functioning modular system. The cell-cycle is a periodic program that regulates DNA synthesis and cell division. Recent biological studies suggest that cell-cycle related genes entrain to this periodic program at the gene translation level, leading to periodically-varying protein levels of these genes. The ribosome flow model (RFM) is a deterministic model obtained via a mean-field approximation of a stochastic model from statistical physics that has been used to model numerous processes including ribosome flow along the mRNA. Here we analyze the RFM under the assumption that the initiation and/or transition rates vary periodically with a common period . We show that the ribosome distribution profile in the RFM entrains to this periodic excitation. In particular, the protein synthesis pattern converges to a unique periodic solution with period . To the best of our knowledge, this is the first proof of entrainment in a mathematical model for translation that encapsulates aspects such as initiation and termination rates, ribosomal movement and interactions, and non-homogeneous elongation speeds along the mRNA. Our results support the conjecture that periodic oscillations in tRNA levels and other factors related to the translation process can induce periodic oscillations in protein levels, and may suggest a new approach for re-engineering genetic systems to obtain a

  7. Strategic Supply

    DTIC Science & Technology

    2002-01-01

    B2C ) or e -business, the average consumer now has the opportunity to order merchandise or services directly for home delivery. Success requires a...Freightwise, Inc., a new e - commerce initiative of the Burlington Northern Santa Fe Corporation, Freightwise offers an on-line marketplace for buyers and...W] e have to put aside the comfortable ways of thinking and planning, take risks and try new things so that we can prepare our forces to deter and

  8. Moving Beyond Strategic Planning to Strategic Thinking.

    ERIC Educational Resources Information Center

    Wolverton, Mimi; Gmelch, Walter

    1999-01-01

    Examines a moderately sized Washington school district's efforts to move beyond strategic planning as a segregated activity toward thinking strategically about long-term plans to govern both tactical operations and the district's future. Top management grew to recognize the legitimacy of multiple external and internal constituent claims. (25…

  9. Creating a nursing strategic planning framework based on evidence.

    PubMed

    Shoemaker, Lorie K; Fischer, Brenda

    2011-03-01

    This article describes an evidence-informed strategic planning process and framework used by a Magnet-recognized public health system in California. This article includes (1) an overview of the organization and its strategic planning process, (2) the structure created within nursing for collaborative strategic planning and decision making, (3) the strategic planning framework developed based on the organization's balanced scorecard domains and the new Magnet model, and (4) the process undertaken to develop the nursing strategic priorities. Outcomes associated with the structure, process, and key initiatives are discussed throughout the article. Copyright © 2011 Elsevier Inc. All rights reserved.

  10. Five-year clinical results of coronary angioplasty with drug-eluting stents. National initiative in strategic innovation, iNOS.

    PubMed

    Baptista, José; Teles, Rui Campante; da Silva, Pedro Canas; Pereira, Hélder; Marques, Leitão; Santos, Ricardo; Carvalho, Henrique; Martins, Dinis; Farto e Abreu, Pedro; Araújo, Jorge; Teles, Rui Campante; Almeida, Manuel; Raposo, Luis; da Silva, Pedro Canas; Gabriel, Henrique Mesquita; Pereira, Helder; Vinhas, Hugo; Leitão-Marques, António; Costa, Marco; Baptista, José; Santos, Ricardo; Seixo, Filipe; Farto e Abreu, Pedro; Carvalho, Henrique; Luz, André; Martins, Dinis; Araújo, Jorge; Silva, Bruno

    2010-02-01

    The use of drug-eluting stents (DES) is beneficial in patients undergoing percutaneous coronary intervention (PCI) and there is particular interest in long-term follow-up. We aimed to assess and characterize early DES use in Portugal during 2003 and patient follow-up over a 5-year period. We developed a web-based database to collect and organize patient and procedural data from PCI performed in ten cardiovascular interventional centers sharing the same database. This was a multicenter retrospective study that included 1833 consecutive angiographically successful coronary angioplasties in which a DES was implanted in 2003. A subgroup of patients with 5-year clinical follow-up after the initial procedure was selected for which there was at least a 90% follow-up rate during one quarter of 2003. Demographic, clinical and angiographic characteristics of the entire population were assessed. In the clinical follow-up cohort, the incidence of major adverse cardiac events (MACE)--death, myocardial infarction and surgical or percutaneous target lesion revascularization--was analyzed by survival curves and logistic regression analysis. Of the total population, 23% were female, and mean age was 62 +/- 11 years (25-92). The main risk factors were hypertension (60.5%), dyslipidemia (42.9%), smoking (45.1%) and diabetes (23.9%, of whom 13.2% were on insulin therapy). There was a history of myocardial infarction, PCI or bypass surgery respectively in 23.1%, 25.1%, and 9.7% of the patients. Multivessel disease was present in 59.9% of patients (mean of 1.86 +/- 0.81 vessels). PCI was performed on average in 1.24 +/- 0.48 lesions, and complete revascularization in 58.8%. A total of 2058 stents were used (mean of 1.62 +/- 0.84) in 1271 patients. The longitudinal substudy included only 320 PCIs, for which follow-up was achieved in 319 (99%; median: 1875 days, P25: 1457 days, P75: 2045 days). Thirty-seven deaths (11.6%) and 61 MACE (19.1%) occurred in this group, with no differences

  11. [INITIAL APPLICATION OF COMPUTER ASSISTED NAVIGATION SYSTEM IN RECONSTRUCTION OF MANDIBULAR DEFECTS].

    PubMed

    Xu, Xu; Zhu Huiyong; Li, Zhiyong; Huang, Xu; Zhao, Wenquan; You, Jia; Wang, Huiming; Liu, Jianhua

    2015-06-01

    To evaluate the value of computer assisted navigation system (CANS) in the reconstruction of mandibular defects. Between April 2012 and September 2014, 8 patients with mandibular defects were included in this study. There were 5 males and 3 females with an age range of 22-50 years (mean, 34.5 years), including 4 cases of ameloblastoma, 3 cases of odontogenic keratocyst, and 1 case of condylar osteoma. According to the CRABS (condyle, ramus, angle, body, symphysis) classification criteria based on the location of mandibular defect, there were 1 case of right CRAB type, 1 case of left RABS type, 1 case of left CR type, 1 case of right RAB type, 1 case of left C type, 1 case of right RABS+left S type, and 2 cases of right AB type. With the biteplate fixing mandible, maxillofacial CT and the donor site CT scan were done. Computer assisted design was made by using Surgicase CMF5.0 software and BrainLab Iplan software, included delineating the osteotomy lines for resection, ascertaining the normal anatomic structures for defect reconstruction, and determining the reconstructive morphology. With guide plates and the guidance of BrainLab navigation system, an en bloc tumor resection and simultaneous defect reconstruction were performed under the precise localization of mandibular angle and condyle. Preoperative and postoperative CT images were superimposed in Geomagic studio12.0 software system, and both were compared by three-dimensional (3D) objects and 2D slices. The complications and signs of recurrence were observed. Under the guidance of navigation, preoperative facial symmetry design, surgery simulation, and simultaneous navigation operation were performed successfully. The postoperative CT and postoperative 3D error analysis showed osteotomy lines and reconstruction contour had good matching with the preoperative planning. The error of important corresponding points (mandibular angle and external pole of condyle) in the reconstruction of mandibular defects were (1

  12. Initial computational fluid dynamics modeling of the Giant Magellan Telescope site and enclosure

    NASA Astrophysics Data System (ADS)

    Danks, Ryan; Smeaton, William; Bigelow, Bruce; Burgett, William

    2016-08-01

    In the era of extremely large telescopes (ELTs), with telescope apertures growing in size and tighter image quality requirements, maintaining a controlled observation environment is critical. Image quality is directly influenced by thermal gradients, the level of turbulence in the incoming air flow and the wind forces acting on the telescope. Thus any ELT enclosure must be able to modulate the speed and direction of the incoming air and limit the inflow of disturbed ground-layer air. However, gaining an a priori understanding of the wind environment's impacts on a proposed telescope is complicated by the fact that telescopes are usually located in remote, mountainous areas, which often do not have high quality historic records of the wind conditions, and can be subjected to highly complex flow patterns that may not be well represented by the traditional analytic approaches used in typical building design. As part of the design process for the Giant Magellan Telescope at Cerro Las Campanas, Chile; the authors conducted a parametric design study using computational fluid dynamics which assessed how the telescope's position on the mesa, its ventilation configuration and the design of the enclosure and windscreens could be optimized to minimize the infiltration of ground-layer air. These simulations yielded an understanding of how the enclosure and the natural wind flows at the site could best work together to provide a consistent, well controlled observation environment. Future work will seek to quantify the aerothermal environment in terms of image quality.

  13. Initial comparison of single cylinder Stirling engine computer model predictions with test results

    NASA Technical Reports Server (NTRS)

    Tew, R. C., Jr.; Thieme, L. G.; Miao, D.

    1979-01-01

    A NASA developed digital computer code for a Stirling engine, modelling the performance of a single cylinder rhombic drive ground performance unit (GPU), is presented and its predictions are compared to test results. The GPU engine incorporates eight regenerator/cooler units and the engine working space is modelled by thirteen control volumes. The model calculates indicated power and efficiency for a given engine speed, mean pressure, heater and expansion space metal temperatures and cooler water inlet temperature and flow rate. Comparison of predicted and observed powers implies that the reference pressure drop calculations underestimate actual pressure drop, possibly due to oil contamination in the regenerator/cooler units, methane contamination in the working gas or the underestimation of mechanical loss. For a working gas of hydrogen, the predicted values of brake power are from 0 to 6% higher than experimental values, and brake efficiency is 6 to 16% higher, while for helium the predicted brake power and efficiency are 2 to 15% higher than the experimental.

  14. National diagnostic reference level initiative for computed tomography examinations in Kenya

    PubMed Central

    Korir, Geoffrey K.; Wambani, Jeska S.; Korir, Ian K.; Tries, Mark A.; Boen, Patrick K.

    2016-01-01

    The purpose of this study was to estimate the computed tomography (CT) examination frequency, patient radiation exposure, effective doses and national diagnostic reference levels (NDRLs) associated with CT examinations in clinical practice. A structured questionnaire-type form was developed for recording examination frequency, scanning protocols and patient radiation exposure during CT procedures in fully equipped medical facilities across the country. The national annual number of CT examinations per 1000 people was estimated to be 3 procedures. The volume-weighted CT dose index, dose length product, effective dose and NDRLs were determined for 20 types of adult and paediatric CT examinations. Additionally, the CT annual collective effective dose and effective dose per capita were approximated. The radiation exposure during CT examinations was broadly distributed between the facilities that took part in the study. This calls for a need to develop and implement diagnostic reference levels as a standardisation and optimisation tool for the radiological protection of patients at all the CT facilities nationwide. PMID:25790825

  15. Initial development of a computer-aided diagnosis tool for solitary pulmonary nodules

    NASA Astrophysics Data System (ADS)

    Catarious, David M., Jr.; Baydush, Alan H.; Floyd, Carey E., Jr.

    2001-07-01

    This paper describes the development of a computer-aided diagnosis (CAD) tool for solitary pulmonary nodules. This CAD tool is built upon physically meaningful features that were selected because of their relevance to shape and texture. These features included a modified version of the Hotelling statistic (HS), a channelized HS, three measures of fractal properties, two measures of spicularity, and three manually measured shape features. These features were measured from a difficult database consisting of 237 regions of interest (ROIs) extracted from digitized chest radiographs. The center of each 256x256 pixel ROI contained a suspicious lesion which was sent to follow-up by a radiologist and whose nature was later clinically determined. Linear discriminant analysis (LDA) was used to search the feature space via sequential forward search using percentage correct as the performance metric. An optimized feature subset, selected for the highest accuracy, was then fed into a three layer artificial neural network (ANN). The ANN's performance was assessed by receiver operating characteristic (ROC) analysis. A leave-one-out testing/training methodology was employed for the ROC analysis. The performance of this system is competitive with that of three radiologists on the same database.

  16. Intraoperative Perfusion Computed Tomography in Carotid Endarterectomy: Initial Experience in 16 Cases

    PubMed Central

    Xue, Zhe; Peng, Dingwei; Sun, Zhenghui; Wu, Chen; Xu, Bainan; Wang, Fuyu; Zhou, Dingbiao; Dong, Tianxiang

    2016-01-01

    Background This study aimed to evaluate the changes in perfusion computed tomography (PCT) parameters in carotid endarterectomy (CEA), and to discuss the use of intraoperative PCT in CEA. Material/Methods Sixteen patients with carotid stenosis who also underwent CEA with intraoperative CT were recruited in this study. We calculated quantitative data on cerebral blood flow (CBF), cerebral blood volume (CBV), time to peak (TTP), and the relative parameter values, including relative CBF (rCBF), relative CBV (rCBV), and relative TTP (rTTP). The role of PCT was assessed and compared to conventional monitoring methods. Results There were no significant differences in any of the parameters in the anterior cerebral artery (ACA) territory (P>0.05). In the middle cerebral artery (MCA) territory, the CBF and CBV increased and TTP decreased in the operated side during CEA; the rCBF and rCBV increased and the rTTP decreased significantly (P<0.05). In 16 patients, CT parameters were improved, SSEP was normal, and MDU was abnormal. In 3 patients, CBF increased by more than 70% during CEA. Relative PCT parameters are sensitive indicators for detecting early cerebral hemodynamic changes during CEA. Cerebral hemodynamics changed significantly in the MCA territory during CEA. Conclusions Intraoperative PCT could be an important adjuvant monitoring method in CEA. PMID:27657307

  17. Initial results from a prototype whole-body photon-counting computed tomography system

    NASA Astrophysics Data System (ADS)

    Yu, Z.; Leng, S.; Jorgensen, S. M.; Li, Z.; Gutjahr, R.; Chen, B.; Duan, X.; Halaweish, A. F.; Yu, L.; Ritman, E. L.; McCollough, C. H.

    2015-03-01

    X-ray computed tomography (CT) with energy-discriminating capabilities presents exciting opportunities for increased dose efficiency and improved material decomposition analyses. However, due to constraints imposed by the inability of photon-counting detectors (PCD) to respond accurately at high photon flux, to date there has been no clinical application of PCD-CT. Recently, our lab installed a research prototype system consisting of two x-ray sources and two corresponding detectors, one using an energy-integrating detector (EID) and the other using a PCD. In this work, we report the first third-party evaluation of this prototype CT system using both phantoms and a cadaver head. The phantom studies demonstrated several promising characteristics of the PCD sub-system, including improved longitudinal spatial resolution and reduced beam hardening artifacts, relative to the EID sub-system. More importantly, we found that the PCD sub-system offers excellent pulse pileup control in cases of x-ray flux up to 550 mA at 140 kV, which corresponds to approximately 2.5×1011 photons per cm2 per second. In an anthropomorphic phantom and a cadaver head, the PCD sub-system provided image quality comparable to the EID sub-system for the same dose level. Our results demonstrate the potential of the prototype system to produce clinically-acceptable images in vivo.

  18. Call for a Computer-Aided Cancer Detection and Classification Research Initiative in Oman.

    PubMed

    Mirzal, Andri; Chaudhry, Shafique Ahmad

    2016-01-01

    Cancer is a major health problem in Oman. It is reported that cancer incidence in Oman is the second highest after Saudi Arabia among Gulf Cooperation Council countries. Based on GLOBOCAN estimates, Oman is predicted to face an almost two-fold increase in cancer incidence in the period 2008-2020. However, cancer research in Oman is still in its infancy. This is due to the fact that medical institutions and infrastructure that play central roles in data collection and analysis are relatively new developments in Oman. We believe the country requires an organized plan and efforts to promote local cancer research. In this paper, we discuss current research progress in cancer diagnosis using machine learning techniques to optimize computer aided cancer detection and classification (CAD). We specifically discuss CAD using two major medical data, i.e., medical imaging and microarray gene expression profiling, because medical imaging like mammography, MRI, and PET have been widely used in Oman for assisting radiologists in early cancer diagnosis and microarray data have been proven to be a reliable source for differential diagnosis. We also discuss future cancer research directions and benefits to Oman economy for entering the cancer research and treatment business as it is a multi-billion dollar industry worldwide.

  19. Initial comparison of single cylinder Stirling engine computer model predictions with test results

    NASA Technical Reports Server (NTRS)

    Tew, R. C., Jr.; Thieme, L. G.; Miao, D.

    1979-01-01

    A NASA developed digital computer code for a Stirling engine, modelling the performance of a single cylinder rhombic drive ground performance unit (GPU), is presented and its predictions are compared to test results. The GPU engine incorporates eight regenerator/cooler units and the engine working space is modelled by thirteen control volumes. The model calculates indicated power and efficiency for a given engine speed, mean pressure, heater and expansion space metal temperatures and cooler water inlet temperature and flow rate. Comparison of predicted and observed powers implies that the reference pressure drop calculations underestimate actual pressure drop, possibly due to oil contamination in the regenerator/cooler units, methane contamination in the working gas or the underestimation of mechanical loss. For a working gas of hydrogen, the predicted values of brake power are from 0 to 6% higher than experimental values, and brake efficiency is 6 to 16% higher, while for helium the predicted brake power and efficiency are 2 to 15% higher than the experimental.

  20. Rectangular computed tomography using a stationary array of CNT emitters: initial experimental results

    NASA Astrophysics Data System (ADS)

    Gonzales, Brian; Spronk, Derrek; Cheng, Yuan; Zhang, Zheng; Pan, Xiaochuan; Beckmann, Moritz; Zhou, Otto; Lu, Jianping

    2013-03-01

    XinRay Systems Inc has a rectangular x-ray computed tomography (CT) imaging setup using multibeam x-ray tubes. These multibeam x-ray tubes are based on cold cathodes using carbon nanotube (CNT) field emitters. Due to their unique design, a CNT x-ray tube can contain a dense array of independently controlled electron emitters which generate a linear array of x-ray focal spots. XinRay uses a set of linear CNT x-ray tubes to design and construct a stationary CT setup which achieves sufficient CT coverage from a fixed set of views. The CT system has no moving gantry, enabling it to be enclosed in a compact rectangular tunnel. The fixed locations of the x-ray focal spots were optimized through simulations. The rectangular shape creates significant variation in path length from the focal spots to the detector for different x-ray views. The shape also results in unequal x-ray coverage in the imaged space. We discuss the impact of this variation on the reconstruction. XinRay uses an iterative reconstruction algorithm to account for this unique geometry, which is implemented on a graphics processing unit (GPU). The fixed focal spots prohibit the use of an antiscatter grid. Quantitative measure of the scatter and its impact on the reconstruction will be discussed. These results represent the first known implementation of a completely stationary CT setup using CNT x-ray emitter arrays.

  1. Including aortic valve morphology in computational fluid dynamics simulations: initial findings and application to aortic coarctation.

    PubMed

    Wendell, David C; Samyn, Margaret M; Cava, Joseph R; Ellwein, Laura M; Krolikowski, Mary M; Gandy, Kimberly L; Pelech, Andrew N; Shadden, Shawn C; LaDisa, John F

    2013-06-01

    Computational fluid dynamics (CFD) simulations quantifying thoracic aortic flow patterns have not included disturbances from the aortic valve (AoV). 80% of patients with aortic coarctation (CoA) have a bicuspid aortic valve (BAV) which may cause adverse flow patterns contributing to morbidity. Our objectives were to develop a method to account for the AoV in CFD simulations, and quantify its impact on local hemodynamics. The method developed facilitates segmentation of the AoV, spatiotemporal interpolation of segments, and anatomic positioning of segments at the CFD model inlet. The AoV was included in CFD model examples of a normal (tricuspid AoV) and a post-surgical CoA patient (BAV). Velocity, turbulent kinetic energy (TKE), time-averaged wall shear stress (TAWSS), and oscillatory shear index (OSI) results were compared to equivalent simulations using a plug inlet profile. The plug inlet greatly underestimated TKE for both examples. TAWSS differences extended throughout the thoracic aorta for the CoA BAV, but were limited to the arch for the normal example. OSI differences existed mainly in the ascending aorta for both cases. The impact of AoV can now be included with CFD simulations to identify regions of deleterious hemodynamics thereby advancing simulations of the thoracic aorta one step closer to reality. Copyright © 2012 IPEM. Published by Elsevier Ltd. All rights reserved.

  2. INCLUDING AORTIC VALVE MORPHOLOGY IN COMPUTATIONAL FLUID DYNAMICS SIMULATIONS: INITIAL FINDINGS AND APPLICATION TO AORTIC COARCTATION

    PubMed Central

    Wendell, David C.; Samyn, Margaret M.; Cava, Joseph R.; Ellwein, Laura M.; Krolikowski, Mary M.; Gandy, Kimberly L.; Pelech, Andrew N.; Shadden, Shawn C.; LaDisa, John F.

    2012-01-01

    Computational fluid dynamics (CFD) simulations quantifying thoracic aortic flow patterns have not included disturbances from the aortic valve (AoV). 80% of patients with aortic coarctation (CoA) have a bicuspid aortic valve (BAV) which may cause adverse flow patterns contributing to morbidity. Our objectives were to develop a method to account for the AoV in CFD simulations, and quantify its impact on local hemodynamics. The method developed facilitates segmentation of the AoV, spatiotemporal interpolation of segments, and anatomic positioning of segments at the CFD model inlet. The AoV was included in CFD model examples of a normal (tricuspid AoV) and a post-surgical CoA patient (BAV). Velocity, turbulent kinetic energy (TKE), time-averaged wall shear stress (TAWSS), and oscillatory shear index (OSI) results were compared to equivalent simulations using a plug inlet profile. The plug inlet greatly underestimated TKE for both examples. TAWSS differences extended throughout the thoracic aorta for the CoA BAV, but were limited to the arch for the normal example. OSI differences existed mainly in the ascending aorta for both cases. The impact of AoV can now be included with CFD simulations to identify regions of deleterious hemodynamics thereby advancing simulations of the thoracic aorta one step closer to reality. PMID:22917990

  3. An initial investigation into methods of computing transonic aerodynamic sensitivity coefficients

    NASA Technical Reports Server (NTRS)

    Carlson, Leland A.

    1994-01-01

    The primary accomplishments of the project are as follows: (1) Using the transonic small perturbation equation as a flowfield model, the project demonstrated that the quasi-analytical method could be used to obtain aerodynamic sensitivity coefficients for airfoils at subsonic, transonic, and supersonic conditions for design variables such as Mach number, airfoil thickness, maximum camber, angle of attack, and location of maximum camber. It was established that the quasi-analytical approach was an accurate method for obtaining aerodynamic sensitivity derivatives for airfoils at transonic conditions and usually more efficient than the finite difference approach. (2) The usage of symbolic manipulation software to determine the appropriate expressions and computer coding associated with the quasi-analytical method for sensitivity derivatives was investigated. Using the three dimensional fully conservative full potential flowfield model, it was determined that symbolic manipulation along with a chain rule approach was extremely useful in developing a combined flowfield and quasi-analytical sensitivity derivative code capable of considering a large number of realistic design variables. (3) Using the three dimensional fully conservative full potential flowfield model, the quasi-analytical method was applied to swept wings (i.e. three dimensional) at transonic flow conditions. (4) The incremental iterative technique has been applied to the three dimensional transonic nonlinear small perturbation flowfield formulation, an equivalent plate deflection model, and the associated aerodynamic and structural discipline sensitivity equations; and coupled aeroelastic results for an aspect ratio three wing in transonic flow have been obtained.

  4. Harnessing the killer micros: Applications from LLNL's massively parallel computing initiative

    SciTech Connect

    Belak, J.F.

    1991-07-01

    Recent developments in microprocessor technology have led to performance on scalar applications exceeding traditional supercomputers. This suggests that coupling hundreds or even thousands of these killer-micros'' (all working on a single physical problem) may lead to performance on vector applications in excess of vector supercomputers. Also, future generation killer-micros are expected to have vector floating point units as well. The purpose of this paper is to present an overview of the parallel computing environment at Lawrence Livermore National Laboratory. However, the perspective is necessarily quite narrow and most of the examples are taken from the author's implementation of a large scale molecular dynamics code on the BBN-TC2000 at LLNL. Parallelism is achieved through a geometric domain decomposition -- each processor is assigned a distinct region of space and all atoms contained therein. As the atomic positions evolve, the processors must exchange ownership of specific atoms. This geometric domain decomposition proves to be quite general and we highlight its application to image processing and hydrodynamics simulations as well. 10 refs., 6 figs.

  5. NASA Strategic Plan

    NASA Technical Reports Server (NTRS)

    1996-01-01

    The aforementioned strategic decisions and the overarching direction for America's aeronautics and space program are addressed in the Strategic Plan. Our Strategic Plan is critical to our ability to meet the challenges of this new era and deliver a vibrant aeronautics and space program that strengthens and inspires the Nation. The Plan is our top-level strategy.

  6. Computational study on the mechanism and kinetics of Cl-initiated oxidation of vinyl acetate

    NASA Astrophysics Data System (ADS)

    Li, Jing; Cao, Haijie; Han, Dandan; Li, Mingyue; Li, Xin; He, Maoxia; Ma, Shuping

    2014-09-01

    A comprehensive theoretical study of chlorine-initiated atmospheric oxidation mechanism of vinyl acetate (VAC, CH2dbnd CHOC(O)CH3) has been performed by using MPWB1K/6-311 + G(3df,2p)//MPWB1K + G(d,p). Two reaction types (Cl-addition and H-abstraction) and the subsequent reactions for the primary intermediates (IM1 and IM2) have been proposed in the presence of O2 and NO. The calculated results show that the Cl addition-elimination mechanism dominates the reaction between vinyl acetate and Cl. For the Cl addition reactions, the most energetically favorable pathway is the Cl addition to the terminal carbon atom. H-abstraction pathways are not expected to play an important role in the final products formation. The major possible degradation products have been identified. The rate constants and branching ratios of the main reaction channels have been obtained over a wide range of temperatures and pressures by using master equation (ME) calculations. The total rate constants are dependent on pressure and temperature over the whole study range (0.1-10,000 Torr and 200-1000 K). The atmospheric lifetime of vinyl acetate is estimated.

  7. Strategic Petroleum Reserves

    SciTech Connect

    Not Available

    1989-01-01

    GAO examined approximately 40 alternative, nontraditional methods of acquiring oil for the Strategic Petroleum Reserve. The alternatives identified were compared to the current method of acquiring and financing SPR oil through congressional appropriations that are reported in the budget. When compared to the conventional method of financing oil, most of the proposals have certain benefits or advantages, but all of them have economic or other disadvantages. For example, some proposals would reduce the budget deficit by increasing government revenues but would raise prices to the consumer. Other proposals would reduce short-term expenditures (asset sales, leasing oil or indexed bonds). However, the proposals might increase long-term expenditures by more than the initial reduction in outlays.

  8. Strategic petroleum reserves

    SciTech Connect

    Not Available

    1989-04-01

    This report has examined approximately 40 alternative, nontraditional methods of acquiring oil for the Strategic Petroleum Reserve. The alternatives identified are compared to the current method of acquiring and financing SPR oil through congressional appropriations that are reported in the budget. When compared to the conventional method of financing oil, most of the proposals have certain benefits or advantages, but all of them have economic or other disadvantages. For example, some proposals would reduce the budget deficit by increasing government revenues but would raise prices to the consumer. Other proposals would reduce short-term expenditures (asset sales, leasing oil or indexed bonds). However, the proposals might increase long-term expenditures by more than the initial reduction in outlays.

  9. Initial quality performance results using a phantom to simulate chest computed radiography.

    PubMed

    Muhogora, Wilbroad; Padovani, Renato; Msaki, Peter

    2011-01-01

    The aim of this study was to develop a homemade phantom for quantitative quality control in chest computed radiography (CR). The phantom was constructed from copper, aluminium, and polymenthylmethacrylate (PMMA) plates as well as Styrofoam materials. Depending on combinations, the literature suggests that these materials can simulate the attenuation and scattering characteristics of lung, heart, and mediastinum. The lung, heart, and mediastinum regions were simulated by 10 mm x 10 mm x 0.5 mm, 10 mm x 10 mm x 0.5 mm and 10 mm x 10 mm x 1 mm copper plates, respectively. A test object of 100 mm x 100 mm and 0.2 mm thick copper was positioned to each region for CNR measurements. The phantom was exposed to x-rays generated by different tube potentials that covered settings in clinical use: 110-120 kVp (HVL=4.26-4.66 mm Al) at a source image distance (SID) of 180 cm. An approach similar to the recommended method in digital mammography was applied to determine the CNR values of phantom images produced by a Kodak CR 850A system with post-processing turned off. Subjective contrast-detail studies were also carried out by using images of Leeds TOR CDR test object acquired under similar exposure conditions as during CNR measurements. For clinical kVp conditions relevant to chest radiography, the CNR was highest over 90-100 kVp range. The CNR data correlated with the results of contrast detail observations. The values of clinical tube potentials at which CNR is the highest are regarded to be optimal kVp settings. The simplicity in phantom construction can offer easy implementation of related quality control program.

  10. Iterative reconstruction in image space (IRIS) in cardiac computed tomography: initial experience.

    PubMed

    Bittencourt, Márcio Sommer; Schmidt, Bernhard; Seltmann, Martin; Muschiol, Gerd; Ropers, Dieter; Daniel, Werner Günther; Achenbach, Stephan

    2011-10-01

    Improvements in image quality in cardiac computed tomography may be achieved through iterative image reconstruction techniques. We evaluated the ability of "Iterative Reconstruction in Image Space" (IRIS) reconstruction to reduce image noise and improve subjective image quality. 55 consecutive patients undergoing coronary CT angiography to rule out coronary artery stenosis were included. A dual source CT system and standard protocols were used. Images were reconstructed using standard filtered back projection and IRIS. Image noise, attenuation within the coronary arteries, contrast, signal to noise and contrast to noise parameters as well as subjective classification of image quality (using a scale with four categories) were evaluated and compared between the two image reconstruction protocols. Subjective image quality (2.8 ± 0.4 in filtered back projection and 2.8 ± 0.4 in iterative reconstruction) and the number of "evaluable" segments per patient 14.0 ± 1.2 in filtered back projection and 14.1 ± 1.1 in iterative reconstruction) were not significant different between the two methods. However iterative reconstruction had a lower image noise (22.6 ± 4.5 HU vs. 28.6 ± 5.1 HU) and higher signal to noise and image to noise ratios in the proximal coronary arteries. IRIS reduces image noise and contrast-to-noise ratio in coronary CT angiography, thus providing potential for reducing radiation exposure.

  11. Towards a user-friendly brain-computer interface: initial tests in ALS and PLS patients.

    PubMed

    Bai, Ou; Lin, Peter; Huang, Dandan; Fei, Ding-Yu; Floeter, Mary Kay

    2010-08-01

    Patients usually require long-term training for effective EEG-based brain-computer interface (BCI) control due to fatigue caused by the demands for focused attention during prolonged BCI operation. We intended to develop a user-friendly BCI requiring minimal training and less mental load. Testing of BCI performance was investigated in three patients with amyotrophic lateral sclerosis (ALS) and three patients with primary lateral sclerosis (PLS), who had no previous BCI experience. All patients performed binary control of cursor movement. One ALS patient and one PLS patient performed four-directional cursor control in a two-dimensional domain under a BCI paradigm associated with human natural motor behavior using motor execution and motor imagery. Subjects practiced for 5-10min and then participated in a multi-session study of either binary control or four-directional control including online BCI game over 1.5-2h in a single visit. Event-related desynchronization and event-related synchronization in the beta band were observed in all patients during the production of voluntary movement either by motor execution or motor imagery. The online binary control of cursor movement was achieved with an average accuracy about 82.1+/-8.2% with motor execution and about 80% with motor imagery, whereas offline accuracy was achieved with 91.4+/-3.4% with motor execution and 83.3+/-8.9% with motor imagery after optimization. In addition, four-directional cursor control was achieved with an accuracy of 50-60% with motor execution and motor imagery. Patients with ALS or PLS may achieve BCI control without extended training, and fatigue might be reduced during operation of a BCI associated with human natural motor behavior. The development of a user-friendly BCI will promote practical BCI applications in paralyzed patients. Copyright 2010 International Federation of Clinical Neurophysiology. All rights reserved.

  12. a New Initiative for Tiling, Stitching and Processing Geospatial Big Data in Distributed Computing Environments

    NASA Astrophysics Data System (ADS)

    Olasz, A.; Nguyen Thai, B.; Kristóf, D.

    2016-06-01

    Within recent years, several new approaches and solutions for Big Data processing have been developed. The Geospatial world is still facing the lack of well-established distributed processing solutions tailored to the amount and heterogeneity of geodata, especially when fast data processing is a must. The goal of such systems is to improve processing time by distributing data transparently across processing (and/or storage) nodes. These types of methodology are based on the concept of divide and conquer. Nevertheless, in the context of geospatial processing, most of the distributed computing frameworks have important limitations regarding both data distribution and data partitioning methods. Moreover, flexibility and expendability for handling various data types (often in binary formats) are also strongly required. This paper presents a concept for tiling, stitching and processing of big geospatial data. The system is based on the IQLib concept (https://github.com/posseidon/IQLib/) developed in the frame of the IQmulus EU FP7 research and development project (http://www.iqmulus.eu). The data distribution framework has no limitations on programming language environment and can execute scripts (and workflows) written in different development frameworks (e.g. Python, R or C#). It is capable of processing raster, vector and point cloud data. The above-mentioned prototype is presented through a case study dealing with country-wide processing of raster imagery. Further investigations on algorithmic and implementation details are in focus for the near future.

  13. Early postmortem volume reduction of adrenal gland: initial longitudinal computed tomographic study.

    PubMed

    Ishida, Masanori; Gonoi, Wataru; Hagiwara, Kazuchika; Okuma, Hidemi; Shirota, Go; Shintani, Yukako; Abe, Hiroyuki; Takazawa, Yutaka; Fukayama, Masashi; Ohtomo, Kuni

    2015-07-01

    We aimed to confirm whether postmortem adrenal volumetric changes occur by measuring adrenal volumes on computed tomography (CT). Fifty-five adrenal glands from 28 subjects who died were included. All subjects underwent antemortem CT (AMCT) and postmortem CT (PMCT) within 94-1,191 min after death, followed by conventional autopsy. CT volumetry was performed using freely-available software. Differences between AMCT and PMCT adrenal volumes were evaluated statistically along with differences in the degree of volume change, elapsed time to PMCT, and presence of underlying malignant disease. The mean volume of the right adrenal gland decreased from 3.8 cm(3) on AMCT to 2.6 cm(3) on PMCT (P < 0.001); the left adrenal gland decreased from 4.2 cm(3) on AMCT to 3.1 cm(3) on PMCT (P < 0.001). Conventional autopsy revealed decreased intracellular lipid components in portions of the adrenal glands. No correlation between the adrenal gland reduction rate and the elapsed time from AMCT to death or from death to PMCT was observed (P = 0.99 and 0.79; P = 0.28 and 0.59 for the right and left adrenal glands, respectively). Significant differences in both the bilateral adrenal gland reduction rates and underlying malignant disease were found for the left adrenal gland (P = 0.015), but not for the right (P = 0.74). Adrenal volume reduction was observed on PMCT compared to AMCT. This highlights the need to further elucidate the mechanism of adrenal shrinkage during the agonal stage and after death. This may be explained by pathological findings of intracellular lipid depletion.

  14. Initial stages of CO2 adsorption on CaO: a combined experimental and computational study.

    PubMed

    Solis, Brian H; Cui, Yi; Weng, Xuefei; Seifert, Jan; Schauermann, Swetlana; Sauer, Joachim; Shaikhutdinov, Shamil; Freund, Hans-Joachim

    2017-02-08

    Room temperature adsorption of carbon dioxide (CO2) on monocrystalline CaO(001) thin films grown on a Mo(001) substrate was studied by infrared reflection-absorption spectroscopy (IRAS) and quantum chemical calculations. For comparison, CO2 adsorption was examined on poorly ordered, nanoparticulate CaO films prepared on Ru(0001). For both systems, CO2 readily adsorbs on the clean CaO surface. However, additional bands were observable on the CaO/Ru(0001) films compared with CaO/Mo(001), because the stricter IRAS surface selection rules do not apply to adsorption on the disordered thin films grown on Ru(0001). Spectral evolution with increasing exposure of the IRA bands suggested the presence of several adsorption sites which are consecutively populated by CO2. Density functional calculations showed that CO2 adsorption occurs as monodentate surface carbonate (CO3(2-)) species at monatomic step sites and other low-coordinated sites, followed by formation of carbonates on terraces, which dominate at increasing CO2 exposure. To explain the coverage-dependent IRAS results, we propose CO2 surface islanding from the onset, most likely in the form of pairs and other chain-like species, which were calculated as thermodynamically favorable. The calculated adsorption energy for isolated CO2 on the terrace sites (184 ± 10 kJ mol(-1)) is larger than the adsorption energy obtained by temperature programmed desorption (∼120-140 kJ mol(-1)) and heat of adsorption taken from microcalorimetry measurements at low coverage (∼125 kJ mol(-1)). However, the calculated adsorption energies become less favorable when carbonate chains intersect on CaO terraces, forming kinks. Furthermore, our assignments of the initial stages of CO2 adsorption are consistent with the observed coverage effect on the CO2 adsorption energy measured by microcalorimetry and the IRAS results.

  15. Resource Utilization and Costs during the Initial Years of Lung Cancer Screening with Computed Tomography in Canada

    PubMed Central

    Lam, Stephen; Tammemagi, Martin C.; Evans, William K.; Leighl, Natasha B.; Regier, Dean A.; Bolbocean, Corneliu; Shepherd, Frances A.; Tsao, Ming-Sound; Manos, Daria; Liu, Geoffrey; Atkar-Khattra, Sukhinder; Cromwell, Ian; Johnston, Michael R.; Mayo, John R.; McWilliams, Annette; Couture, Christian; English, John C.; Goffin, John; Hwang, David M.; Puksa, Serge; Roberts, Heidi; Tremblay, Alain; MacEachern, Paul; Burrowes, Paul; Bhatia, Rick; Finley, Richard J.; Goss, Glenwood D.; Nicholas, Garth; Seely, Jean M.; Sekhon, Harmanjatinder S.; Yee, John; Amjadi, Kayvan; Cutz, Jean-Claude; Ionescu, Diana N.; Yasufuku, Kazuhiro; Martel, Simon; Soghrati, Kamyar; Sin, Don D.; Tan, Wan C.; Urbanski, Stefan; Xu, Zhaolin; Peacock, Stuart J.

    2014-01-01

    Background: It is estimated that millions of North Americans would qualify for lung cancer screening and that billions of dollars of national health expenditures would be required to support population-based computed tomography lung cancer screening programs. The decision to implement such programs should be informed by data on resource utilization and costs. Methods: Resource utilization data were collected prospectively from 2059 participants in the Pan-Canadian Early Detection of Lung Cancer Study using low-dose computed tomography (LDCT). Participants who had 2% or greater lung cancer risk over 3 years using a risk prediction tool were recruited from seven major cities across Canada. A cost analysis was conducted from the Canadian public payer’s perspective for resources that were used for the screening and treatment of lung cancer in the initial years of the study. Results: The average per-person cost for screening individuals with LDCT was $453 (95% confidence interval [CI], $400–$505) for the initial 18-months of screening following a baseline scan. The screening costs were highly dependent on the detected lung nodule size, presence of cancer, screening intervention, and the screening center. The mean per-person cost of treating lung cancer with curative surgery was $33,344 (95% CI, $31,553–$34,935) over 2 years. This was lower than the cost of treating advanced-stage lung cancer with chemotherapy, radiotherapy, or supportive care alone, ($47,792; 95% CI, $43,254–$52,200; p = 0.061). Conclusion: In the Pan-Canadian study, the average cost to screen individuals with a high risk for developing lung cancer using LDCT and the average initial cost of curative intent treatment were lower than the average per-person cost of treating advanced stage lung cancer which infrequently results in a cure. PMID:25105438

  16. Is Mohammed a Strategic Leader?

    DTIC Science & Technology

    2011-03-01

    and expansion of Islam initiated by Mohammed and ended with the collapse of the Umayyad Dynasty .16 At the height of this period of expansion, Islam...spreading Islam early in his life while in Mecca. Some have placed the estimate at 100 people converted to Islam in the first thirteen years of peaceful...Mohammed remains an extraordinary world figure and a strategic leader even almost thirteen centuries after his death. Islam continues to expand

  17. The strategic importance of data.

    PubMed

    Glaser, John; Markell, Peter; Stone, John

    2010-02-01

    Two factors--accountability for care and an increased adoption of interoperable electronic health records (EHRs)--will significantly increase the importance of data for healthcare organizations. These factors have significant data ramifications in four areas: payment reform, data use policies, IT strategy, and data management. As data become a strategic asset, healthcare finance executives will need to become significant contributors to their organizations' EHR initiatives and data management strategies.

  18. Learning to think strategically.

    PubMed

    1994-01-01

    Strategic thinking focuses on issues that directly affect the ability of a family planning program to attract and retain clients. This issue of "The Family Planning Manager" outlines the five steps of strategic thinking in family planning administration: 1) define the organization's mission and strategic goals; 2) identify opportunities for improving quality, expanding access, and increasing demand; 3) evaluate each option in terms of its compatibility with the organization's goals; 4) select an option; and 5) transform strategies into action. Also included in this issue is a 20-question test designed to permit readers to assess their "strategic thinking quotient" and a list of sample questions to guide a strategic analysis.

  19. [Positron emission tomography combined with computed tomography in the initial evaluation and response assessment in primary central nervous system lymphoma].

    PubMed

    Mercadal, Santiago; Cortés-Romera, Montserrat; Vélez, Patricia; Climent, Fina; Gámez, Cristina; González-Barca, Eva

    2015-06-08

    To evaluate the role of positron emission tomography combined with computed tomography (PET-CT) in the initial evaluation and response assessment in primary central nervous system lymphoma (PCNSL). Fourteen patients (8 males) with a median age 59.5 years diagnosed of PCNSL. A brain PET-CT and magnetic resonance imaging (MRI) were performed in the initial evaluation. In 7 patients a PET-CT after treatment was performed. PET-CT showed at diagnosis 31 hypermetabolic focuses and MRI showed 47 lesions, with a good grade of concordance between both (k = 0.61; P = .005). In the response assessment, correlation between both techniques was good, and PET-CT was helpful in the appreciation of residual MRI lesions. Overall survival at 2 years of negative vs. positive PET-CT at the end of treatment was 100 vs. 37.5%, respectively (P = .045). PET-CT can be useful in the initial evaluation of PCNSL, and especially in the assessment of response. Despite the fact that PET-CT detects less small lesions than MRI, a good correlation between MRI and PET-CT was observed. It is effective in the evaluation of residual lesions. Prospective studies are needed to confirm their possible prognostic value. Copyright © 2014 Elsevier España, S.L.U. All rights reserved.

  20. Strategic bombers

    SciTech Connect

    Not Available

    1992-07-01

    This paper reports on the questions: should Congress provide more funds for the Air Force's current plan---the CORE program---to upgrade the B-1B defense avionics system In GAO's view, more testing of the system is not necessary to determine whether to implement the CORE program. Flight testing has shown that the CORE modifications would provide similar operational capabilities to, and offer some survivability improvements over, the existing defense avionics system. The only reason for additional testing would be to prove that some problems with the maintenance diagnostic system has been resolved. Initial testing revealed that while some improvements were achieved, user requirements were not met for such things as low false alarm rates and cannot duplicate rates. Even if the maintenance diagnostic capabilities were fully demonstrated, however, the CORE system should not be implemented until it is known whether the defense avionics system design can support the B-1B's new role as a conventional bomber.

  1. Strategic Analysis Overview

    NASA Technical Reports Server (NTRS)

    Cirillo, William M.; Earle, Kevin D.; Goodliff, Kandyce E.; Reeves, J. D.; Stromgren, Chel; Andraschko, Mark R.; Merrill, R. Gabe

    2008-01-01

    NASA s Constellation Program employs a strategic analysis methodology in providing an integrated analysis capability of Lunar exploration scenarios and to support strategic decision-making regarding those scenarios. The strategic analysis methodology integrates the assessment of the major contributors to strategic objective satisfaction performance, affordability, and risk and captures the linkages and feedbacks between all three components. Strategic analysis supports strategic decision making by senior management through comparable analysis of alternative strategies, provision of a consistent set of high level value metrics, and the enabling of cost-benefit analysis. The tools developed to implement the strategic analysis methodology are not element design and sizing tools. Rather, these models evaluate strategic performance using predefined elements, imported into a library from expert-driven design/sizing tools or expert analysis. Specific components of the strategic analysis tool set include scenario definition, requirements generation, mission manifesting, scenario lifecycle costing, crew time analysis, objective satisfaction benefit, risk analysis, and probabilistic evaluation. Results from all components of strategic analysis are evaluated a set of pre-defined figures of merit (FOMs). These FOMs capture the high-level strategic characteristics of all scenarios and facilitate direct comparison of options. The strategic analysis methodology that is described in this paper has previously been applied to the Space Shuttle and International Space Station Programs and is now being used to support the development of the baseline Constellation Program lunar architecture. This paper will present an overview of the strategic analysis methodology and will present sample results from the application of the strategic analysis methodology to the Constellation Program lunar architecture.

  2. Constructing the ASCI computational grid

    SciTech Connect

    BEIRIGER,JUDY I.; BIVENS,HUGH P.; HUMPHREYS,STEVEN L.; JOHNSON,WILBUR R.; RHEA,RONALD E.

    2000-06-01

    The Accelerated Strategic Computing Initiative (ASCI) computational grid is being constructed to interconnect the high performance computing resources of the nuclear weapons complex. The grid will simplify access to the diverse computing, storage, network, and visualization resources, and will enable the coordinated use of shared resources regardless of location. To match existing hardware platforms, required security services, and current simulation practices, the Globus MetaComputing Toolkit was selected to provide core grid services. The ASCI grid extends Globus functionality by operating as an independent grid, incorporating Kerberos-based security, interfacing to Sandia's Cplant{trademark},and extending job monitoring services. To fully meet ASCI's needs, the architecture layers distributed work management and criteria-driven resource selection services on top of Globus. These services simplify the grid interface by allowing users to simply request ''run code X anywhere''. This paper describes the initial design and prototype of the ASCI grid.

  3. The National Nanotechnology Initiative. Strategic Plan

    DTIC Science & Technology

    2007-12-01

    organic contaminants from groundwater. Magnetite nanoparticles have shown promise for removing arsenic from drinking water . Sensors based on...Nanomaterials: Research aimed at the discovery of novel nanoscale and nanostructured materials and at a comprehensive understanding of the properties of...controlled manner, nanostructured materials with targeted properties. Nanoscale Devices and Systems: R&D that applies the principles of nanoscale science

  4. STRATEGIC BIOMONITORING INITIATIVES: MOVING THE SCIENCE FORWARD

    EPA Science Inventory

    Biomonitoring programs in the United States and Europe demonstrate the vast array of data that are publicly available for the evaluation of exposure trends, identification of susceptible populations, detection of emerging chemical risks, the conduct of epidemiology studies, and ...

  5. Strategic Mobility 21 Initial Capabilities Document (ICD)

    DTIC Science & Technology

    2006-07-28

    vendor managed inventory and trans-loading opportunities • Provide additional cargo security and military force protection Functional Concepts...The next 3 gaps are: 9. Cargo Booking, 10. DoD Activity Address Codes (DODACC) Management , and 11. Inventory Receipts and Accountability. July 27...pack and pallet level, and introduction of vendor managed mini-containers into the distribution network. AMC will also benefit significantly from

  6. Strategic Defense Initiative Organization Data Center Overview

    DTIC Science & Technology

    2007-11-02

    180 and Delta 181 experiments. The PDC is located at the Arnold Engineering Development Center (AEDC), Arnold Air Force Base , Tennessee. Engineering...DESC archives and distributes directed energy data such as accuracy information on Ground Based Laser (GBL) Boost Phase Intercept. It also serves as a...science operations center for directed energy (DE) field experiments. The DESC is located at Falcon Air Force Base , near Colorado Springs, Colorado

  7. 2010 Neuroscience Director’s Strategic Initiative

    DTIC Science & Technology

    2011-02-01

    distribution unlimited. 13. SUPPLEMENTARY NOTES 14. ABSTRACT Understanding how Soldiers’ cognitive abilities meet the increasing demands of dynamic...In order to acquire, monitor, and assess Soldier sensory, perceptual, emotional, cognitive , and physical performance within realistic operational...brain state classification algorithm from EEG data acquired from participants performing tasks with varied cognitive demands. Third, Kaleb McDowell

  8. Strategic Defense Initiative: Bibliography and research guide

    SciTech Connect

    Lawrence, R.M.

    1986-01-01

    In his Star Wars speech in 1983, the president asked the scientific community to pursue research and development of hardware and software that would enable the nation to switch from the deterrence doctrine of Mutual Assured Destruction (MAD) to a policy based on the unilateral capability to physically defend the country against ballistic missile attack. The author has assembled approximately 1,000 citations-including books, monographs, articles, and government documents-that reflect the full spectrum of thought on the issue. Seminal references have been abstracted and divided into three sections: technical background of the debate, arguments in favor of the SDI, and arguments against the SDI. Each section contains an essay that integrates and amplifies the information presented in the abstracted materials.

  9. A telepresence robotic system operated with a P300-based brain-computer interface: initial tests with ALS patients.

    PubMed

    Escolano, Carlos; Ramos Murguialday, Ander; Matuz, Tamara; Birbaumer, Niels; Minguez, Javier

    2010-01-01

    Brain-computer interfaces (BCIs) open a new valuable communication channel for people with severe neurological or motor degenerative diseases, such as ALS patients. On the other hand, the ability to teleoperate robots in a remote scenario provides a physical entity embodied in a real environment ready to perceive, explore, and interact. The combination of both functionalities provides a system with benefits for ALS patients in the context of neurorehabilitation or maintainment of the neural activity. This paper reports a BCI telepresence system which offers navigation, exploration and bidirectional communication, only controlled by brain activity; and an initial study of applicability with ALS patients. The results show the feasibility of this technology in real patients.

  10. Evaluation of Computer-Aided System Design Tools for SDI (Strategic Defense Initiative) Battle Management/C3 (Command, Control and Communications) Architecture Development

    DTIC Science & Technology

    1987-10-01

    able to create such annotations as a designer recognizes a technical issue or trade-off, or makes a decision that should be recorded. It is also...complexity, and the interests and technical knowledge of different reviewers, call for a means to easily produce non-standard reports on a system design... technical matters of protection, coordination, and integration of design content. Protection involves shared, but protected access to parts of a system under

  11. A Computer for Every Student and Teacher: Lessons Learned about Planning and Implementing a Successful 1:1 Learning Initiative in Schools

    ERIC Educational Resources Information Center

    Corn, Jenifer O.; Oliver, Kevin M.; Hess, Clara E.; Halstead, Elizabeth O.; Argueta, Rodolfo; Patel, Ruchi K.; Tingen, Jennifer; Huff, Jessica D.

    2010-01-01

    Twelve high schools in North Carolina piloted a 1:1 learning initiative, where every student and teacher received a laptop computer with wireless Internet access provided throughout the school. The overall goals of the initiative were to improve teaching practices; increase student achievement; and better prepare students for work, citizenship,…

  12. A web-based computer aided system for liver surgery planning: initial implementation on RayPlus

    NASA Astrophysics Data System (ADS)

    Luo, Ming; Yuan, Rong; Sun, Zhi; Li, Tianhong; Xie, Qingguo

    2016-03-01

    At present, computer aided systems for liver surgery design and risk evaluation are widely used in clinical all over the world. However, most systems are local applications that run on high-performance workstations, and the images have to processed offline. Compared with local applications, a web-based system is accessible anywhere and for a range of regardless of relative processing power or operating system. RayPlus (http://rayplus.life.hust.edu.cn), a B/S platform for medical image processing, was developed to give a jump start on web-based medical image processing. In this paper, we implement a computer aided system for liver surgery planning on the architecture of RayPlus. The system consists of a series of processing to CT images including filtering, segmentation, visualization and analyzing. Each processing is packaged into an executable program and runs on the server side. CT images in DICOM format are processed step by to interactive modeling on browser with zero-installation and server-side computing. The system supports users to semi-automatically segment the liver, intrahepatic vessel and tumor from the pre-processed images. Then, surface and volume models are built to analyze the vessel structure and the relative position between adjacent organs. The results show that the initial implementation meets satisfactorily its first-order objectives and provide an accurate 3D delineation of the liver anatomy. Vessel labeling and resection simulation are planned to add in the future. The system is available on Internet at the link mentioned above and an open username for testing is offered.

  13. Strategic learning in healthcare organizations.

    PubMed

    O'Sullivan, M J

    1999-01-01

    There is no definitive blueprint for the healthcare organization involved in strategic learning. However, what distinguishes strategic learning institutions is their acknowledgment that they must discover their own paths and solutions rather than blindly follow a detailed strategic mandate from administration. Answers to their most critical implementation and adaptive questions will not flow down ready-made from above, but will be tailored to meet the requirements of their own particular situation. Strategic learning organizations have certain attributes in common in developing their own answers: They continuously experiment rather than seek final solutions. They favor improvisation over forecasts. They formulate new actions rather than defend past ones. They nurture change rather than permanence. They encourage creative conflict rather than tranquillity. They encourage questioning rather than compliance. They expose contradictions rather than hide them (Weick 1977). Most importantly, strategic learning organizations realize that successful strategic change is best undertaken as a process of learning (O'Sullivan 1999). Healthcare organizations can no longer afford the illusion of traditional strategic planning, with its emphasis on bureaucratic controls from the top to the bottom. They must embrace the fundamental truth that most change occurs through processes of learning that occur in many locations simultaneously throughout the organization. The initial step in discovering ways to improve the capability of healthcare organizations is to adapt continuously while fulfilling their mission. Healthcare leaders must create a shared vision of where an institution is heading rather than what the final destination will be, nurture a spirit of experimentation and discovery rather than close supervision and unbending control, and recognize that plans have to be continuously changed and adjusted. To learn means to face the unknown: to recognize that we do not possess all

  14. Strategic Planning Process at the National Technical Information Service,

    DTIC Science & Technology

    funding, and advances in automation, have dictated the need for information services to have a strong commitment to strategic planning . This paper...describes these trends and outlines the strategic planning process at the National Technical Information Service (NTIS). Initially resisted, strategic ... planning has become an important component of the agency management system. In recent years the planning system has been linked with performance plans of

  15. A Strategic Planning Process for NATO for the 1990s

    DTIC Science & Technology

    1992-06-01

    This thesis deals with the possible shifts in NATO’s strategy for the rest of the 1990s. It uses a strategic planning model to explore these possible...shift’s in strategy. Strategic planning is a systematic process of defining the mission and the objectives and creating action plans, policies and...resource allocations to achieve them. Every organization should initiate strategic planning in order to address the evolving needs of its stakeholders

  16. Rehabilitation: strategic, proactive, flexible, risky?

    PubMed

    Green, R H

    2000-12-01

    Rehabilitation after armed conflict is a direct intellectual descendant of thinking about rehabilitation after natural calamity. It is related, generally, to poverty reduction and, operationally, to associated action at the micro level. This history has limited its strategic conceptualisation and, in particular, its links with reconciliation and state re-legitimation and also with macro-economic stabilisation and renewed growth. In post-war--or more generally, a lull in conflict with the potential to become permanent--a country's rapid, focused, prioritised action within a strategic framework is urgent. It is not risk-free for political and natural disasters as well as for those with economic and social bases. Flexibility, learning from initial experience and asking intended household beneficiaries about their needs in advance can reduce risk as can pre-positioning of contingency or standby resources to avert post-war calamities (for example, drought, flood) and catastrophes (renewed violence) from delaying and discrediting rehabilitation efforts.

  17. Strategic groups, performance, and strategic response in the nursing home industry.

    PubMed Central

    Zinn, J S; Aaronson, W E; Rosko, M D

    1994-01-01

    OBJECTIVE. This study examines the effect of strategic group membership on nursing home performance and strategic behavior. DATA SOURCES AND STUDY SETTING. Data from the 1987 Medicare and Medicaid Automated Certification Survey were combined with data from the 1987 and 1989 Pennsylvania Long Term Care Facility Questionnaire. The sample consisted of 383 Pennsylvania nursing homes. STUDY DESIGN. Cluster analysis was used to place the 383 nursing homes into strategic groups on the basis of variables measuring scope and resource deployment. Performance was measured by indicators of the quality of nursing home care (rates of pressure ulcers, catheterization, and restraint usage) and efficiency in services provision. Changes in Medicare participation after passage of the 1988 Medicare Catastrophic Coverage Act (MCCA) measured strategic behavior. MANOVA and Turkey HSD post hoc means tests determined if significant differences were associated with strategic group membership. FINDINGS. Cluster analysis produced an optimal seven-group solution. Differences in group means were significant for the clustering, performance, and conduct variables (p < .0001). Strategic groups characterized by facilities providing a continuum of care services had the best patient care outcomes. The most efficient groups were characterized by facilities with high Medicare census. While all strategic groups increased Medicare census following passage of the MCCA, those dominated by for-profits had the greatest increases. CONCLUSIONS. Our analysis demonstrates that strategic orientation influences nursing home response to regulatory initiatives, a factor that should be recognized in policy formation directed at nursing home reform. PMID:8005789

  18. Strategic planning for neuroradiologists.

    PubMed

    Berlin, Jonathan W; Lexa, Frank J

    2012-08-01

    Strategic planning is becoming essential to neuroradiology as the health care environment continues to emphasize cost efficiency, teamwork and collaboration. A strategic plan begins with a mission statement and vision of where the neuroradiology division would like to be in the near future. Formalized strategic planning frameworks, such as the strengths, weaknesses, opportunities and threats (SWOT), and the Balanced Scorecard frameworks, can help neuroradiology divisions determine their current position in the marketplace. Communication, delegation, and accountability in neuroradiology is essential in executing an effective strategic plan.

  19. Sandia Strategic Plan 1997

    SciTech Connect

    1997-12-01

    Sandia embarked on its first exercise in corporate strategic planning during the winter of 1989. The results of that effort were disseminated with the publication of Strategic Plan 1990. Four years later Sandia conducted their second major planning effort and published Strategic Plan 1994. Sandia`s 1994 planning effort linked very clearly to the Department of Energy`s first strategic plan, Fueling a Competitive Economy. It benefited as well from the leadership of Lockheed Martin Corporation, the management and operating contractor. Lockheed Martin`s corporate success is founded on visionary strategic planning and annual operational planning driven by customer requirements and technology opportunities. In 1996 Sandia conducted another major planning effort that resulted in the development of eight long-term Strategic Objectives. Strategic Plan 1997 differs from its predecessors in that the robust elements of previous efforts have been integrated into one comprehensive body. The changes implemented so far have helped establish a living strategic plan with a stronger business focus and with clear deployment throughout Sandia. The concept of a personal line of sight for all employees to this strategic plan and its objectives, goals, and annual milestones is becoming a reality.

  20. Simulating materials failure by using up to one billion atoms and the world's fastest computer: Work-hardening

    NASA Astrophysics Data System (ADS)

    Abraham, Farid F.; Walkup, Robert; Gao, Huajian; Duchaineau, Mark; Diaz de La Rubia, Tomas; Seager, Mark

    2002-04-01

    We describe the second of two large-scale atomic simulation projects on materials failure performed on the 12-teraflop ASCI (Accelerated Strategic Computing Initiative) White computer at the Lawrence Livermore National Laboratory. This investigation simulates ductile failure by using more than one billion atoms where the true complexity of the creation and interaction of hundreds of dislocations are revealed.

  1. Creating a pipeline of talent for informatics: STEM initiative for high school students in computer science, biology, and biomedical informatics

    PubMed Central

    Dutta-Moscato, Joyeeta; Gopalakrishnan, Vanathi; Lotze, Michael T.; Becich, Michael J.

    2014-01-01

    This editorial provides insights into how informatics can attract highly trained students by involving them in science, technology, engineering, and math (STEM) training at the high school level and continuing to provide mentorship and research opportunities through the formative years of their education. Our central premise is that the trajectory necessary to be expert in the emergent fields in front of them requires acceleration at an early time point. Both pathology (and biomedical) informatics are new disciplines which would benefit from involvement by students at an early stage of their education. In 2009, Michael T Lotze MD, Kirsten Livesey (then a medical student, now a medical resident at University of Pittsburgh Medical Center (UPMC)), Richard Hersheberger, PhD (Currently, Dean at Roswell Park), and Megan Seippel, MS (the administrator) launched the University of Pittsburgh Cancer Institute (UPCI) Summer Academy to bring high school students for an 8 week summer academy focused on Cancer Biology. Initially, pathology and biomedical informatics were involved only in the classroom component of the UPCI Summer Academy. In 2011, due to popular interest, an informatics track called Computer Science, Biology and Biomedical Informatics (CoSBBI) was launched. CoSBBI currently acts as a feeder program for the undergraduate degree program in bioinformatics at the University of Pittsburgh, which is a joint degree offered by the Departments of Biology and Computer Science. We believe training in bioinformatics is the best foundation for students interested in future careers in pathology informatics or biomedical informatics. We describe our approach to the recruitment, training and research mentoring of high school students to create a pipeline of exceptionally well-trained applicants for both the disciplines of pathology informatics and biomedical informatics. We emphasize here how mentoring of high school students in pathology informatics and biomedical informatics

  2. Comparison of computational fluid dynamics findings with intraoperative microscopy findings in unruptured intracranial aneurysms- An initial analysis

    PubMed Central

    Talari, Sandeep; Kato, Yoko; Shang, Hanbing; Yamada, Yasuhiro; Yamashiro, Kei; Suyama, Daisuke; Kawase, Tsukasa; Balik, Vladimir; Rile, Wu

    2016-01-01

    Context: The increase in the detection of unruptured cerebral aneurysms has led to management dilemma. Prediction of risk based on the size of the aneurysm is not always accurate. There is no objective way of predicting rupture of aneurysm so far. Computational fluid dynamics (CFDs) was proposed as a tool to identify the rupture risk. Aims: To know the correlation of CFD findings with intraoperative microscopic findings and to know the relevance of CFD in the prediction of rupture risk and in the management of unruptured intracranial aneurysms. Settings and Design: A prospective study involving nine cases over a period of 6 months as an initial analysis. Subjects and Methods: Both males and females were included in the study. Preoperative analysis was performed using computed tomography angiogram, magnetic resonance imaging in all cases and digital substraction angiogram in some cases. Intraoperatively microscopic examination of the aneurysm wall was carried out and images recorded. The correlation was done between microscopic and CFD images. Results: Seven cases were found intraoperatively to have a higher risk of rupture based on the thinning of the wall. Two cases had an atherosclerotic wall. All cases had low wall shear stress (WSS).Only two cases with atherosclerotic wall had a correlation with low WSS. Conclusions: While the pressure measured with CFD technique is a good predictor of rupture risk, the WSS component is controversial. Multicentric trials involving a larger subset of population are needed before drawing any definite conclusions. On-going development in the CFD analysis may help to predict the rupture chances accurately in future. PMID:27695537

  3. Creating a pipeline of talent for informatics: STEM initiative for high school students in computer science, biology, and biomedical informatics.

    PubMed

    Dutta-Moscato, Joyeeta; Gopalakrishnan, Vanathi; Lotze, Michael T; Becich, Michael J

    2014-01-01

    This editorial provides insights into how informatics can attract highly trained students by involving them in science, technology, engineering, and math (STEM) training at the high school level and continuing to provide mentorship and research opportunities through the formative years of their education. Our central premise is that the trajectory necessary to be expert in the emergent fields in front of them requires acceleration at an early time point. Both pathology (and biomedical) informatics are new disciplines which would benefit from involvement by students at an early stage of their education. In 2009, Michael T Lotze MD, Kirsten Livesey (then a medical student, now a medical resident at University of Pittsburgh Medical Center (UPMC)), Richard Hersheberger, PhD (Currently, Dean at Roswell Park), and Megan Seippel, MS (the administrator) launched the University of Pittsburgh Cancer Institute (UPCI) Summer Academy to bring high school students for an 8 week summer academy focused on Cancer Biology. Initially, pathology and biomedical informatics were involved only in the classroom component of the UPCI Summer Academy. In 2011, due to popular interest, an informatics track called Computer Science, Biology and Biomedical Informatics (CoSBBI) was launched. CoSBBI currently acts as a feeder program for the undergraduate degree program in bioinformatics at the University of Pittsburgh, which is a joint degree offered by the Departments of Biology and Computer Science. We believe training in bioinformatics is the best foundation for students interested in future careers in pathology informatics or biomedical informatics. We describe our approach to the recruitment, training and research mentoring of high school students to create a pipeline of exceptionally well-trained applicants for both the disciplines of pathology informatics and biomedical informatics. We emphasize here how mentoring of high school students in pathology informatics and biomedical informatics

  4. A Strategic Defense Initiative Organization Software Testing Initiative

    DTIC Science & Technology

    1990-10-01

    Pentagon Washir gton, DC 20301-7100 Other Defense Technical Information Center 2 Cameron Station Alexandria, VA 22314 Dr. Dan Alpert , Director Program in...Science, Technology & Society University of Illinois Room 201 912-1/2 West Illinois Street Urbana, Illinois 61801 IDA General Larry D. Welch, HQ 1 Mr

  5. The Strategic Development of the Trinidad and Tobago Defence Force

    DTIC Science & Technology

    2009-06-12

    direction, 5. the general environment, 6. a SWOT analysis , 7. critical success factors, 8. strategic objectives, 9. strategic choices, 10. programmes...revealed the organization‘s opportunities and threats. Known as SWOT analysis , Andrews‘ work derived its name from the use of the initial letter of...66 CHAPTER 4 ANALYSIS

  6. Orchestrating energy for shifting busyness to strategic work.

    PubMed

    Shirey, Maria R; Hites, Lisle

    2015-03-01

    This department highlights change management strategies that may be successful in strategically planning and executing organizational change initiatives. In this article, the authors discuss the elements of busy work and offers strategies for shifting to focused, strategic work. A useful energy preservation framework is introduced to promote vitality that drives engagement, productivity, and innovation.

  7. Learning Strategic Planning from Australian and New Zealand University Experience

    ERIC Educational Resources Information Center

    Zhang, Anfu

    2014-01-01

    Initiating a strategic development plan is necessary for universities to be managed scientifically; a university's strategic development plan includes both the educational philosophy and development orientation as determined by the university, including the future reallocation of resources and measures for their integration. The development…

  8. Learning Strategic Planning from Australian and New Zealand University Experience

    ERIC Educational Resources Information Center

    Zhang, Anfu

    2014-01-01

    Initiating a strategic development plan is necessary for universities to be managed scientifically; a university's strategic development plan includes both the educational philosophy and development orientation as determined by the university, including the future reallocation of resources and measures for their integration. The development…

  9. Contribution of Global Polio Eradication Initiative-Funded Personnel to the Strengthening of Routine Immunization Programs in the 10 Focus Countries of the Polio Eradication and Endgame Strategic Plan.

    PubMed

    van den Ent, Maya M V X; Swift, Rachel D; Anaokar, Sameer; Hegg, Lea Anne; Eggers, Rudolf; Cochi, Stephen L

    2017-07-01

    The Polio Eradication and Endgame Strategic Plan (PEESP) established a target that at least 50% of the time of personnel receiving funding from the Global Polio Eradication Initiative (GPEI) for polio eradication activities (hereafter, "GPEI-funded personnel") should be dedicated to the strengthening of immunization systems. This article describes the self-reported profile of how GPEI-funded personnel allocate their time toward immunization goals and activities beyond those associated with polio, the training they have received to conduct tasks to strengthen routine immunization systems, and the type of tasks they have conducted. A survey of approximately 1000 field managers of frontline GPEI-funded personnel was conducted by Boston Consulting Group in the 10 focus countries of the PEESP during 2 phases, in 2013 and 2014, to determine time allocation among frontline staff. Country-specific reports on the training of GPEI-funded personnel were reviewed, and an analysis of the types of tasks that were reported was conducted. A total of 467 managers responded to the survey. Forty-seven percent of the time (range, 23%-61%) of GPEI-funded personnel was dedicated to tasks related to strengthening immunization programs, other than polio eradication. Less time was spent on polio-associated activities in countries that had already interrupted wild poliovirus (WPV) transmission, compared with findings for WPV-endemic countries. All countries conducted periodic trainings of the GPEI-funded personnel. The types of non-polio-related tasks performed by GPEI-funded personnel varied among countries and included surveillance, microplanning, newborn registration and defaulter tracing, monitoring of routine immunization activities, and support of district immunization task teams, as well as promotion of health behaviors, such as clean-water use and good hygiene and sanitation practices. In all countries, GPEI-funded personnel perform critical tasks in the strengthening of routine

  10. Keeping the Strategic Flame

    DTIC Science & Technology

    1997-01-01

    thinking strategically fifty years ago when he observed what nuclear weapons implied: “Thus far the chief purpose of our military establishment has...reached beyond available technol- ogy. Airmen in that day were thinking strategically and thus laid the founda- tions for American security policies

  11. Strategic Risk Assessment

    NASA Technical Reports Server (NTRS)

    Derleth, Jason; Lobia, Marcus

    2009-01-01

    This slide presentation provides an overview of the attempt to develop and demonstrate a methodology for the comparative assessment of risks across the entire portfolio of NASA projects and assets. It includes information about strategic risk identification, normalizing strategic risks, calculation of relative risk score, and implementation options.

  12. Manage "Human Capital" Strategically

    ERIC Educational Resources Information Center

    Odden, Allan

    2011-01-01

    To strategically manage human capital in education means restructuring the entire human resource system so that schools not only recruit and retain smart and capable individuals, but also manage them in ways that support the strategic directions of the organization. These management practices must be aligned with a district's education improvement…

  13. Manage "Human Capital" Strategically

    ERIC Educational Resources Information Center

    Odden, Allan

    2011-01-01

    To strategically manage human capital in education means restructuring the entire human resource system so that schools not only recruit and retain smart and capable individuals, but also manage them in ways that support the strategic directions of the organization. These management practices must be aligned with a district's education improvement…

  14. 11. Strategic planning.

    PubMed

    2014-05-01

    There are several types of planning processes and plans, including strategic, operational, tactical, and contingency. For this document, operational planning includes tactical planning. This chapter examines the strategic planning process and includes an introduction into disaster response plans. "A strategic plan is an outline of steps designed with the goals of the entire organisation as a whole in mind, rather than with the goals of specific divisions or departments". Strategic planning includes all measures taken to provide a broad picture of what must be achieved and in which order, including how to organise a system capable of achieving the overall goals. Strategic planning often is done pre-event, based on previous experience and expertise. The strategic planning for disasters converts needs into a strategic plan of action. Strategic plans detail the goals that must be achieved. The process of converting needs into plans has been deconstructed into its components and includes consideration of: (1) disaster response plans; (2) interventions underway or planned; (3) available resources; (4) current status vs. pre-event status; (5) history and experience of the planners; and (6) access to the affected population. These factors are tempered by the local: (a) geography; (b) climate; (c) culture; (d) safety; and (e) practicality. The planning process consumes resources (costs). All plans must be adapted to the actual conditions--things never happen exactly as planned.

  15. Strategic Leadership in Schools

    ERIC Educational Resources Information Center

    Williams, Henry S.; Johnson, Teryl L.

    2013-01-01

    Strategic leadership is built upon traits and actions that encompass the successful execution of all leadership styles. In a world that is rapidly changing, strategic leadership in schools guides school leader through assuring constant improvement process by anticipating future trends and planning for them and noting that plans must be flexible to…

  16. Strategic Investments Overview

    NASA Technical Reports Server (NTRS)

    Comstock, Doug

    2004-01-01

    This viewgraph presentation provides an overview of the organizational hierarchy for strategic management and strategic investments at NASA. The presentation also relates these topics to the budgets it submits to Congress, strategies for space exploration research and development, and systems analysis.

  17. Strategic Leadership in Schools

    ERIC Educational Resources Information Center

    Williams, Henry S.; Johnson, Teryl L.

    2013-01-01

    Strategic leadership is built upon traits and actions that encompass the successful execution of all leadership styles. In a world that is rapidly changing, strategic leadership in schools guides school leader through assuring constant improvement process by anticipating future trends and planning for them and noting that plans must be flexible to…

  18. Developing Strategic Readers

    ERIC Educational Resources Information Center

    Jones, Jennifer; Leahy, Susie

    2006-01-01

    As elementary students progress from "learning to read" toward "reading to learn," it is vital that they become strategic readers. A strategic reader is one who understands when and how to use a strategy in order to comprehend text. While some students use strategies naturally during the reading process, most students must be taught how to…

  19. A Computational Neurodegenerative Disease Progression Score: Method and Results with the Alzheimer’s Disease Neuroimaging Initiative Cohort

    PubMed Central

    Jedynak, Bruno M.; Lang, Andrew; Liu, Bo; Katz, Elyse; Zhang, Yanwei; Wyman, Bradley T.; Raunig, David; Jedynak, C. Pierre; Caffo, Brian; Prince, Jerry L.

    2012-01-01

    While neurodegenerative diseases are characterized by steady degeneration over relatively long timelines, it is widely believed that the early stages are the most promising for therapeutic intervention, before irreversible neuronal loss occurs. Developing a therapeutic response requires a precise measure of disease progression. However, since the early stages are for the most part asymptomatic, obtaining accurate measures of disease progression is difficult. Longitudinal databases of hundreds of subjects observed during several years with tens of validated biomarkers are becoming available, allowing the use of computational methods. We propose a widely applicable statistical methodology for creating a disease progression score (DPS), using multiple biomarkers, for subjects with a neurodegenerative disease. The proposed methodology was evaluated for Alzheimer’s disease (AD) using the publicly available AD Neuroimaging Initiative (ADNI) database, yielding an Alzheimer’s DPS or ADPS score for each subject and each time-point in the database. In addition, a common description of biomarker changes was produced allowing for an ordering of the biomarkers. The Rey Auditory Verbal Learning Test delayed recall was found to be the earliest biomarker to become abnormal. The group of biomarkers comprising the volume of the hippocampus and the protein concentration amyloid beta and Tau were next in the timeline, and these were followed by three cognitive biomarkers. The proposed methodology thus has potential to stage individuals according to their state of disease progression relative to a population and to deduce common behaviors of biomarkers in the disease itself. PMID:22885136

  20. Development and initial validation of a computer-administered health literacy assessment in Spanish and English: FLIGHT/VIDAS.

    PubMed

    Ownby, Raymond L; Acevedo, Amarilis; Waldrop-Valverde, Drenna; Jacobs, Robin J; Caballero, Joshua; Davenport, Rosemary; Homs, Ana-Maria; Czaja, Sara J; Loewenstein, David

    2013-01-01

    Current measures of health literacy have been criticized on a number of grounds, including use of a limited range of content, development on small and atypical patient groups, and poor psychometric characteristics. In this paper, we report the development and preliminary validation of a new computer-administered and -scored health literacy measure addressing these limitations. Items in the measure reflect a wide range of content related to health promotion and maintenance as well as care for diseases. The development process has focused on creating a measure that will be useful in both Spanish and English, while not requiring substantial time for clinician training and individual administration and scoring. The items incorporate several formats, including questions based on brief videos, which allow for the assessment of listening comprehension and the skills related to obtaining information on the Internet. In this paper, we report the interim analyses detailing the initial development and pilot testing of the items (phase 1 of the project) in groups of Spanish and English speakers. We then describe phase 2, which included a second round of testing of the items, in new groups of Spanish and English speakers, and evaluation of the new measure's reliability and validity in relation to other measures. Data are presented that show that four scales (general health literacy, numeracy, conceptual knowledge, and listening comprehension), developed through a process of item and factor analyses, have significant relations to existing measures of health literacy.

  1. Effect of Initial Microstructure on the Performance of 6XXX Al-alloy Laser Welds: A Computational Study

    NASA Astrophysics Data System (ADS)

    Samaras, Spiros N.

    2016-05-01

    Laser welding (LW) offers an attractive joining technique for Al-alloys. The performance of laser welds usually suffers from mechanical strength degradation in the heat-affected zone (HAZ). In the present study, the effect of the initial-aged microstructure on the post-welded state of 6XXX Al-alloys laser welds was examined via computational modeling techniques. A well-established and detailed precipitation model was used, coupled with a strength model. The influence of the main process variables for aging heat treatment (time and temperature) and LW (power and speed) on the mechanical integrity of weld joints and specifically in the yield strength profile in the HAZ was analyzed. Also, a simple method for the prediction of the width of HAZ is provided. It is concluded that more coarsened microstructures show better performance (compared with the aged state) due to lower degradation of mechanical strength and narrower width of HAZ on the post-welded state. This study provides a method for the selection of the appropriate process parameters for aging and LW of 6XXX Al-alloys.

  2. Networking as a Strategic Tool, 1991

    NASA Technical Reports Server (NTRS)

    1991-01-01

    This conference focuses on the technological advances, pitfalls, requirements, and trends involved in planning and implementing an effective computer network system. The basic theme of the conference is networking as a strategic tool. Tutorials and conference presentations explore the technology and methods involved in this rapidly changing field. Future directions are explored from a global, as well as local, perspective.

  3. Becoming a Strategic Language Learner in CALL

    ERIC Educational Resources Information Center

    Cohen, Andrew D.

    2007-01-01

    This article outlines what it means to be a strategic language learner in the context of Computer-Assisted Language Learning (CALL). It looks at the possible roles for language learner strategies at their crucial intersection with language learning technology. We will first consider what language learner strategies have been represented in…

  4. Strategic Management or Strategic Planning for Defense?

    DTIC Science & Technology

    1989-02-01

    manage at the regional or CinC level with an appreciation of strategic planning and management concepts currently taught at business schools . Military...those not in uniform. Science, engineering, and business schools all suggest that their faculties have experience tours so that they can appreciate

  5. American Strategic Minerals

    NASA Astrophysics Data System (ADS)

    DeYoung, John H., Jr.; Chidester, Alfred H.

    American Strategic Minerals is a collection of six papers that were presented in December 1982 at a conference organized by the Center for the Study of Marine Policy at the University of Delaware. According to editor Gerard J. Mangone, director of the center, the papers were commissioned “to investigate not only the objective resource situation, but also past United States policy on strategic minerals and future options open to Washington.” The authors and their chapter titles are John C. Kraft, University of Delaware: “Strategic minerals and world stability” V. Anthony Cammarota, Jr., U.S. Bureau of Mines: “America's dependence on strategic minerals” John D. Morgan, U.S. Bureau of Mines: “Future demands of the United States for strategic minerals” J. Robert Moore, University of Texas: “Alternative sources of strategic minerals from the seabed” Allan I. Mendelowitz and John E. Watson, U.S. General Accounting Office: “U.S. mining investments in developing countries” and James W. Curlin, Nautilus Press: “The political dimensions of strategic minerals.”

  6. Strategic Plan. Volume 1

    NASA Technical Reports Server (NTRS)

    2002-01-01

    The purpose of this document is to present the strategic plan and associated organizational structure that the National Space Biomedical Research Institute (NSBRI) will utilize to achieve the defined mission and objectives provided by NASA. Much of the information regarding the background and establishment of the NSBRI by NASA has been provided in other documentation and will not be repeated in this Strategic Plan. This Strategic Plan is presented in two volumes. Volume I (this volume) begins with an Introduction (Section 2) that provides the Institute's NASA-defined mission and objectives, and the organizational structure adopted to implement these through three Strategic Programs: Countermeasure Research; Education, Training and Outreach; and Cooperative Research and Development. These programs are described in Sections 3 to 5. Each program is presented in a similar way, using four subsections: Goals and Objectives; Current Strategies; Gaps and Modifications; and Resource Requirements. Section 6 provides the administrative infrastructure and total budget required to implement the Strategic Programs and assures that they form a single cohesive plan. This plan will ensure continued success of the Institute for the next five years. Volume II of the Strategic Plan provides an in-depth analysis of the current and future strategic programs of the 12 current NSBRI teams, including their goals, objectives, mutual interactions and schedules.

  7. 45 CFR 233.35 - Computing the assistance payment under retrospective budgeting after the initial one or two...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Computing the assistance payment under... FINANCIAL ASSISTANCE PROGRAMS § 233.35 Computing the assistance payment under retrospective budgeting after... shall be computed retrospectively, i.e., shall be based on income and other relevant circumstances...

  8. Strategic Planning for Information Resources Management.

    ERIC Educational Resources Information Center

    Penrod, James; Dolence, Michael

    1987-01-01

    In 1985, California State University/Los Angeles changed the management of its information resources by hiring a vice president for information resources management; reorganizing existing units into an IRM organization; engaging in a detailed, integrated, participative strategic planning process; and initiating several significant projects.…

  9. Strengthening Board Capacity for Strategic Financial Oversight

    ERIC Educational Resources Information Center

    Wellman, Jane V.

    2008-01-01

    This paper is the last in a series of reports and initiatives in AGB's Cost Project. The project was designed to build governing board capacity to monitor institutional costs effectively and strategically. Costs and productivity are not new issues in higher education. AGB and its member governing boards have long recognized the importance of…

  10. Strategic School Funding for Improved Student Achievement

    ERIC Educational Resources Information Center

    Chambers, Jay G.; Brown, James R.; Levin, Jesse; Jubb, Steve; Harper, Dorothy; Tolleson, Ray; Manship, Karen

    2010-01-01

    This article features Strategic School Funding for Results (SSFR) project, a new joint initiative of the American Institutes for Research (AIR) and Pivot Learning Partners (PLP) aimed at improving school finance, human resources, and management systems in large urban school districts. The goal of the project is to develop and implement more…

  11. Strengthening Board Capacity for Strategic Financial Oversight

    ERIC Educational Resources Information Center

    Wellman, Jane V.

    2008-01-01

    This paper is the last in a series of reports and initiatives in AGB's Cost Project. The project was designed to build governing board capacity to monitor institutional costs effectively and strategically. Costs and productivity are not new issues in higher education. AGB and its member governing boards have long recognized the importance of…

  12. Advances in Parallel Computing and Databases for Digital Pathology in Cancer Research

    DTIC Science & Technology

    2016-11-13

    Through a number of efforts such as the National Strategic Computing Initiative (NSCI), there has been a push to merge these “ Big Data ” and...potential for applications in cancer research. II. PARALLEL COMPUTING AND BIG DATA Parallel computing is the ability to take a given program and split it...Recently, we have been developing a “Polystore” database system called BigDAWG (short for the Big Data Working Group) that brings together disparate DBMSs

  13. Strategic petroleum reserve data acquisition system

    SciTech Connect

    Merillat, P D; Bauer, A G

    1980-10-01

    The Strategic Petroleum Reserve Data Acquisition System is a general purpose, digital data acquisition system designed for field use in the DOE's Strategic Petroleum Reserve testing and monitoring program. The system is computer driven, under the control of an operator. The system is designed to allow the operator to perform pre-test system configuration; test monitoring and control; and post test analysis. This document is a system description and an operator users manual. Topics covered include: configuration and running on-line tests, software documentation, and maintenance programming information.

  14. Strategic agility for nursing leadership.

    PubMed

    Shirey, Maria R

    2015-06-01

    This department highlights change management strategies that may be successful in strategically planning and executing organizational change. In this article, the author discusses strategic agility as an important leadership competency and offers approaches for incorporating strategic agility in healthcare systems. A strategic agility checklist and infrastructure-building approach are presented.

  15. Computational study of cyclohexanone-monomer co-initiation mechanism in thermal homo-polymerization of methyl acrylate and methyl methacrylate.

    PubMed

    Liu, Shi; Srinivasan, Sriraj; Grady, Michael C; Soroush, Masoud; Rappe, Andrew M

    2012-06-07

    This paper presents a systematic computational study of the mechanism of cyclohexanone-monomer co-initiation in high-temperature homopolymerization of methyl acrylate (MA) and methyl methacrylate (MMA). Previous experimental studies of spontaneous thermal homopolymerization of MA and MMA showed higher monomer conversion in the presence of cyclohexanone than xylene. However, these studies did not reveal the initiation mechanism(s) or the initiating species. To identify the initiation mechanism and the initiating species, we explore four different mechanisms, (1) Kaim, (2) Flory, (3) α-position hydrogen transfer, and (4) Mayo, using first-principles density functional theory (DFT) and second-order Møller-Plesset perturbation theory (MP2) calculations. Transition-state geometries for each mechanism are determined using B3LYP/6-31G* and assessed with MP2/6-31G*. Activation energies and rate constants are calculated using transition-state theory. The harmonic oscillator approximation and tunneling corrections are applied to compute the reaction rate constants. This study indicates that α-position hydrogen transfer and Mayo mechanisms have comparable barriers and are capable of generating monoradicals for initiating polymerization of MA and MMA; these two mechanisms can cause cyclohexanone-monomer co-initiation in thermal polymerization of MA and MMA.

  16. Development and Initial Psychometric Properties of the Computer Assisted Maltreatment Inventory (CAMI): A Comprehensive Self-Report Measure of Child Maltreatment History

    ERIC Educational Resources Information Center

    DiLillo, David; Hayes-Skelton, Sarah A.; Fortier, Michelle A.; Perry, Andrea R.; Evans, Sarah E.; Messman Moore, Terri L.; Walsh, Kate; Nash, Cindy; Fauchier, Angele

    2010-01-01

    Objectives: The present study reports on the development and initial psychometric properties of the Computer Assisted Maltreatment Inventory (CAMI), a web-based self-report measure of child maltreatment history, including sexual and physical abuse, exposure to interparental violence, psychological abuse, and neglect. Methods: The CAMI was…

  17. Development and Initial Psychometric Properties of the Computer Assisted Maltreatment Inventory (CAMI): A Comprehensive Self-Report Measure of Child Maltreatment History

    ERIC Educational Resources Information Center

    DiLillo, David; Hayes-Skelton, Sarah A.; Fortier, Michelle A.; Perry, Andrea R.; Evans, Sarah E.; Messman Moore, Terri L.; Walsh, Kate; Nash, Cindy; Fauchier, Angele

    2010-01-01

    Objectives: The present study reports on the development and initial psychometric properties of the Computer Assisted Maltreatment Inventory (CAMI), a web-based self-report measure of child maltreatment history, including sexual and physical abuse, exposure to interparental violence, psychological abuse, and neglect. Methods: The CAMI was…

  18. Engineering Forum Strategic Plan

    EPA Pesticide Factsheets

    This Strategic Plan highlights the purpose, mission, goals, and objectives of the U.S. Environmental Protection Agency (EPA) Engineering Forum (EF). It sets forth the principles that guide the EF's decision-making, helps clarify the EF's priorities, and...

  19. Information and strategic voting.

    PubMed

    Tyszler, Marcelo; Schram, Arthur

    2016-01-01

    We theoretically and experimentally study voter behavior in a setting characterized by plurality rule and mandatory voting. Voters choose from three options. We are interested in the occurrence of strategic voting in an environment where Condorcet cycles may occur and focus on how information about the preference distribution affects strategic behavior. We also vary the relative importance of the second preferred option. Quantal response equilibrium analysis is used to analyze the game and derive predictions. Our results indeed show that strategic voting arises. Its extent depends on (i) information availability; (ii) the relative importance of the intermediate candidate; (iii) the electorate's relative support for one's preferred candidate; (iv) the relative position of the plurality-supported candidate in one's preference ordering. Our results show that information serves as a coordination device where strategic voting does not harm the plurality-preferred candidate's chances of winning.

  20. The IAU Strategic Plan

    NASA Astrophysics Data System (ADS)

    Miley, George

    2016-10-01

    I shall review the content of the IAU Strategic Plan (SP) to use astronomy as a tool for stimulating development globally during the decade 2010 - 2020. Considerable progress has been made in its implementation since the last General Assembly.

  1. 2015 Enterprise Strategic Vision

    SciTech Connect

    2015-08-01

    This document aligns with the Department of Energy Strategic Plan for 2014-2018 and provides a framework for integrating our missions and direction for pursuing DOE’s strategic goals. The vision is a guide to advancing world-class science and engineering, supporting our people, modernizing our infrastructure, and developing a management culture that operates a safe and secure enterprise in an efficient manner.

  2. Computational modes and the Machenauer N.L.N.M.I. of the GLAS 4th order model. [NonLinear Normal Mode Initialization in numerical weather forecasting

    NASA Technical Reports Server (NTRS)

    Navon, I. M.; Bloom, S.; Takacs, L. L.

    1985-01-01

    An attempt was made to use the GLAS global 4th order shallow water equations to perform a Machenhauer nonlinear normal mode initialization (NLNMI) for the external vertical mode. A new algorithm was defined for identifying and filtering out computational modes which affect the convergence of the Machenhauer iterative procedure. The computational modes and zonal waves were linearly initialized and gravitational modes were nonlinearly initialized. The Machenhauer NLNMI was insensitive to the absence of high zonal wave numbers. The effects of the Machenhauer scheme were evaluated by performing 24 hr integrations with nondissipative and dissipative explicit time integration models. The NLNMI was found to be inferior to the Rasch (1984) pseudo-secant technique for obtaining convergence when the time scales of nonlinear forcing were much smaller than the time scales expected from the natural frequency of the mode.

  3. Computational modes and the Machenauer N.L.N.M.I. of the GLAS 4th order model. [NonLinear Normal Mode Initialization in numerical weather forecasting

    NASA Technical Reports Server (NTRS)

    Navon, I. M.; Bloom, S.; Takacs, L. L.

    1985-01-01

    An attempt was made to use the GLAS global 4th order shallow water equations to perform a Machenhauer nonlinear normal mode initialization (NLNMI) for the external vertical mode. A new algorithm was defined for identifying and filtering out computational modes which affect the convergence of the Machenhauer iterative procedure. The computational modes and zonal waves were linearly initialized and gravitational modes were nonlinearly initialized. The Machenhauer NLNMI was insensitive to the absence of high zonal wave numbers. The effects of the Machenhauer scheme were evaluated by performing 24 hr integrations with nondissipative and dissipative explicit time integration models. The NLNMI was found to be inferior to the Rasch (1984) pseudo-secant technique for obtaining convergence when the time scales of nonlinear forcing were much smaller than the time scales expected from the natural frequency of the mode.

  4. Excretory urography and computed tomography in the initial evaluation of patients with cervical cancer: are both examinations necessary

    SciTech Connect

    Goldman, S.M.; Fishman, E.K.; Rosenshein, N.B.; Gatewood, O.M.B.; Siegelman, S.S.

    1984-11-01

    One hundred ten patients with carcinoma of the cervix were studied to determine if both excretory urography and computed tomography are needed for routine evaluation. Computed tomography gave more information in 25 patients and the excretory urogram was more informative in 10 patients. Thirty-five hydroureters were detected by computed tomography, whereas excretory urography identified 21. It was concluded that routine use of both examinations is not indicated. Excretory urography is currently sufficient in evaluation of stage I and IIA lesions, while computed tomography obviates excretory urography in patients with advanced cervical cancer (IIB-IVB).

  5. Working and strategic memory deficits in schizophrenia

    NASA Technical Reports Server (NTRS)

    Stone, M.; Gabrieli, J. D.; Stebbins, G. T.; Sullivan, E. V.

    1998-01-01

    Working memory and its contribution to performance on strategic memory tests in schizophrenia were studied. Patients (n = 18) and control participants (n = 15), all men, received tests of immediate memory (forward digit span), working memory (listening, computation, and backward digit span), and long-term strategic (free recall, temporal order, and self-ordered pointing) and nonstrategic (recognition) memory. Schizophrenia patients performed worse on all tests. Education, verbal intelligence, and immediate memory capacity did not account for deficits in working memory in schizophrenia patients. Reduced working memory capacity accounted for group differences in strategic memory but not in recognition memory. Working memory impairment may be central to the profile of impaired cognitive performance in schizophrenia and is consistent with hypothesized frontal lobe dysfunction associated with this disease. Additional medial-temporal dysfunction may account for the recognition memory deficit.

  6. Working and strategic memory deficits in schizophrenia

    NASA Technical Reports Server (NTRS)

    Stone, M.; Gabrieli, J. D.; Stebbins, G. T.; Sullivan, E. V.

    1998-01-01

    Working memory and its contribution to performance on strategic memory tests in schizophrenia were studied. Patients (n = 18) and control participants (n = 15), all men, received tests of immediate memory (forward digit span), working memory (listening, computation, and backward digit span), and long-term strategic (free recall, temporal order, and self-ordered pointing) and nonstrategic (recognition) memory. Schizophrenia patients performed worse on all tests. Education, verbal intelligence, and immediate memory capacity did not account for deficits in working memory in schizophrenia patients. Reduced working memory capacity accounted for group differences in strategic memory but not in recognition memory. Working memory impairment may be central to the profile of impaired cognitive performance in schizophrenia and is consistent with hypothesized frontal lobe dysfunction associated with this disease. Additional medial-temporal dysfunction may account for the recognition memory deficit.

  7. Scientific Component Technology Initiative

    SciTech Connect

    Kohn, S; Bosl, B; Dahlgren, T; Kumfert, G; Smith, S

    2003-02-07

    The laboratory has invested a significant amount of resources towards the development of high-performance scientific simulation software, including numerical libraries, visualization, steering, software frameworks, and physics packages. Unfortunately, because this software was not designed for interoperability and re-use, it is often difficult to share these sophisticated software packages among applications due to differences in implementation language, programming style, or calling interfaces. This LDRD Strategic Initiative investigated and developed software component technology for high-performance parallel scientific computing to address problems of complexity, re-use, and interoperability for laboratory software. Component technology is an extension of scripting and object-oriented software development techniques that specifically focuses on the needs of software interoperability. Component approaches based on CORBA, COM, and Java technologies are widely used in industry; however, they do not support massively parallel applications in science and engineering. Our research focused on the unique requirements of scientific computing on ASCI-class machines, such as fast in-process connections among components, language interoperability for scientific languages, and data distribution support for massively parallel SPMD components.

  8. Implications of the President's strategic defense initiative and antisatellite weapons policy. Hearings before the Subcommittee on Arms Control, International Security and Science of the Committee on Foreign Affairs, House of Representatives, Ninety-Ninth Congress, First Session, April 24 and May 1, 1985

    SciTech Connect

    Not Available

    1985-01-01

    The House of Representatives, Committee on Foreign Affairs, Subcommittee on Arms Control, International Security and Science held hearings on April 24 and May 1, 1985, to consider the implications of the strategic defense initiative and antisatellite weapons policy for arms control in space. This document is the transcript of that hearing and includes the prepared statements of congressmen, two former secretaries of defense and representatives of several organizations concerned with arms control. Previously published reports and the text of the ABM Treaty are attached as appendices.

  9. Introduction of International Microgravity Strategic Planning Group

    NASA Technical Reports Server (NTRS)

    Rhome, Robert

    1998-01-01

    Established in May 6, 1995, the purpose of this International Strategic Planning Group for Microgravity Science and Applications Research is to develop and update, at least on a biennial basis, an International Strategic Plan for Microgravity Science and Applications Research. The member space agencies have agreed to contribute to the development of a Strategic Plan, and seek the implementation of the cooperative programs defined in this Plan. The emphasis of this plan is the coordination of hardware construction and utilization within the various areas of research including biotechnology, combustion science, fluid physics, materials science and other special topics in physical sciences. The Microgravity Science and Applications International Strategic Plan is a joint effort by the present members - ASI, CNES, CSA, DLR, ESA, NASA, and NASDA. It represents the consensus from a series of discussions held within the International Microgravity Strategic Planning Group (IMSPG). In 1996 several space agencies initiated multilateral discussions on how to improve the effectiveness of international microgravity research during the upcoming Space Station era. These discussions led to a recognition of the need for a comprehensive strategic plan for international microgravity research that would provide a framework for cooperation between international agencies. The Strategic Plan is intended to provide a basis for inter-agency coordination and cooperation in microgravity research in the environment of the International Space Station (ISS) era. This will be accomplished through analysis of the interests and goals of each participating agency and identification of mutual interests and program compatibilities. The Plan provides a framework for maximizing the productivity of space-based research for the benefit of our societies.

  10. Introduction of International Microgravity Strategic Planning Group

    NASA Technical Reports Server (NTRS)

    Rhome, Robert

    1998-01-01

    Established in May 6, 1995, the purpose of this International Strategic Planning Group for Microgravity Science and Applications Research is to develop and update, at least on a biennial basis, an International Strategic Plan for Microgravity Science and Applications Research. The member space agencies have agreed to contribute to the development of a Strategic Plan, and seek the implementation of the cooperative programs defined in this Plan. The emphasis of this plan is the coordination of hardware construction and utilization within the various areas of research including biotechnology, combustion science, fluid physics, materials science and other special topics in physical sciences. The Microgravity Science and Applications International Strategic Plan is a joint effort by the present members - ASI, CNES, CSA, DLR, ESA, NASA, and NASDA. It represents the consensus from a series of discussions held within the International Microgravity Strategic Planning Group (IMSPG). In 1996 several space agencies initiated multilateral discussions on how to improve the effectiveness of international microgravity research during the upcoming Space Station era. These discussions led to a recognition of the need for a comprehensive strategic plan for international microgravity research that would provide a framework for cooperation between international agencies. The Strategic Plan is intended to provide a basis for inter-agency coordination and cooperation in microgravity research in the environment of the International Space Station (ISS) era. This will be accomplished through analysis of the interests and goals of each participating agency and identification of mutual interests and program compatibilities. The Plan provides a framework for maximizing the productivity of space-based research for the benefit of our societies.

  11. Strategic forces briefing

    SciTech Connect

    Bing, G.; Chrzanowski, P.; May, M.; Nordyke, M.

    1989-04-06

    The Strategic Forces Briefing'' is our attempt, accomplished over the past several months, to outline and highlight the more significant strategic force issues that must be addressed in the near future. Some issues are recurrent: the need for an effective modernized Triad and a constant concern for force survivability. Some issues derive from arms control: the Strategic Arms Reduction Talks (SALT) are sufficiently advanced to set broad numerical limits on forces, but not so constraining as to preclude choices among weapon systems and deployment modes. Finally, a new administration faced with serious budgetary problems must strive for the most effective strategic forces limited dollars can buy and support. A review of strategic forces logically begins with consideration of the missions the forces are charged with. We begin the briefing with a short review of targeting policy and implementation within the constraints of available unclassified information. We then review each element of the Triad with sections on SLBMs, ICBMs, and Air-Breathing (bomber and cruise missile) systems. A short section at the end deals with the potential impact of strategic defense on offensive force planning. We consider ABM, ASAT, and air defense; but we do not attempt to address the technical issues of strategic defense per se. The final section gives a brief overview of the tritium supply problem. We conclude with a summary of recommendations that emerge from our review. The results of calculation on the effectiveness of various weapon systems as a function of cost that are presented in the briefing are by Paul Chrzanowski.

  12. Role of single photon emission computed tomography/computed tomography in diagnostic iodine-131 scintigraphy before initial radioiodine ablation in differentiated thyroid cancer

    PubMed Central

    Agrawal, Kanhaiyalal; Bhattacharya, Anish; Mittal, Bhagwant Rai

    2015-01-01

    Objectives: The study was performed to evaluate the incremental value of single photon emission computed tomography/computed tomography (SPECT/CT) over planar radioiodine imaging before radioiodine ablation in the staging, management and stratification of risk of recurrence (ROR) in differentiated thyroid cancer (DTC) patients. Materials and Methods: Totally, 83 patients (21 male, 62 female) aged 17–75 (mean 39.9) years with DTC were included consecutively in this prospective study. They underwent postthyroidectomy planar and SPECT/CT scans after oral administration of 37–114 MBq iodine-131 (I-131). The scans were interpreted as positive, negative or suspicious for tracer uptake in the thyroid bed, cervical lymph nodes and sites outside the neck. In each case, the findings on planar images were recorded first, without knowledge of SPECT/CT findings. Operative and pathological findings were used for postsurgical tumor–node–metastasis staging. The tumor staging was reassessed after each of these two scans. Results: Single photon emission computed tomography/computed tomography localized radioiodine uptake in the thyroid bed in 9/83 (10.8%) patients, neck nodes in 24/83 (28.9%) patients and distant metastases in 8/83 (9.6%) patients in addition to the planar study. Staging was changed in 8/83 (9.6%), ROR in 11/83 (13.2%) and management in 26/83 (31.3%) patients by the pretherapy SPECT/CT in comparison to planar imaging. SPECT/CT had incremental value in 32/83 patients (38.5%) over the planar scan. Conclusion: Single photon emission computed tomography/computed tomography is feasible during a diagnostic I-131 scan with a low amount of radiotracer. It improved the interpretation of pretherapy I-131 scintigraphy and changed the staging and subsequent patient management. PMID:26170564

  13. Design of a digital beam attenuation system for computed tomography. Part II. Performance study and initial results

    SciTech Connect

    Szczykutowicz, Timothy P.; Mistretta, Charles A.

    2013-02-15

    Purpose: The purpose of this work is to present a performance study of the digital beam attenuator (DBA) for implementing fluence field modulated CT (FFMCT) using a simulation framework developed to model the incorporation of the DBA into an existing CT system. Additionally, initial results will be presented using a prototype DBA and the realization of the prototype will be described. To our knowledge, this study represents the first experimental use of a device capable of modulating x-ray fluence as a function of fan angle using a CT geometry. Methods: To realize FFMCT, the authors propose to use a wedge design in which one wedge is held stationary and another wedge is moved over the stationary wedge. Due to the wedge shape, the composite thickness of the two wedges changes as a function of the amount of overlap between the wedges. This design allows for the wedges to modulate the photon fluence incident onto a patient. Using a simulation environment, the effect of changing the number of wedges has on dose, scatter, detector dynamic range, and noise uniformity is explored. Experimental results are presented using a prototype DBA having ten Fe wedges and a c-arm CT system geometry. The experimental DBA results are compared to non-DBA scans using scatter and detector dynamic range as metrics. Both flat field and bowtie filtered CT acquisitions were simulated for comparison with the DBA. Results: Numerical results suggest that substantial gains in noise uniformity and scatter-to-primary ratio (SPR) can be obtained using only seven wedges. After seven wedges, the decrease in noise ununiformity and SPR falls off at a lower rate. Simulations comparing CT acquisitions between flat field, bowtie enabled, and DBA CT acquisitions suggest DBA-FFMCT can reduce dose relative to flat field CT by Almost-Equal-To 3 times. A bowtie filter under the same imaging conditions was shown to only allow a dose reduction of 1.65 times. Experimentally, a 10 wedge DBA prototype result showed

  14. Skeletal muscle metastases as the initial manifestation of an unknown primary lung cancer detected on F-18 fluorodeoxyglucose positron emission tomography/computed tomography.

    PubMed

    Agrawal, Kanhaiyalal; Bhattacharya, Anish; Singh, Navneet; Harisankar, Chidambaram Natarajan Balasubramanian; Mittal, Bhagwant Rai

    2013-01-01

    Skeletal muscle metastasis as the initial presentation of the unknown primary lung cancer is unusual. A 65-year-old male patient presented with pain and swelling of the right forearm. Fine needle aspiration of the swelling revealed metastatic squamous cell carcinoma. The patient underwent whole body F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) to identify the site of the primary malignancy. The authors present PET/CT images showing FDG-avid metastases to the skeletal muscles along with a previously unknown primary tumor in the right lung, in a patient presenting with initial muscular symptoms without any pulmonary manifestations.

  15. NASA Enterprise Managed Cloud Computing (EMCC): Delivering an Initial Operating Capability (IOC) for NASA use of Commercial Infrastructure-as-a-Service (IaaS)

    NASA Technical Reports Server (NTRS)

    O'Brien, Raymond

    2017-01-01

    In 2016, Ames supported the NASA CIO in delivering an initial operating capability for Agency use of commercial cloud computing. This presentation provides an overview of the project, the services approach followed, and the major components of the capability that was delivered. The presentation is being given at the request of Amazon Web Services to a contingent representing the Brazilian Federal Government and Defense Organization that is interested in the use of Amazon Web Services (AWS). NASA is currently a customer of AWS and delivered the Initial Operating Capability using AWS as its first commercial cloud provider. The IOC, however, designed to also support other cloud providers in the future.

  16. NASA's activities in the conservation of strategic aerospace materials

    NASA Technical Reports Server (NTRS)

    Stephens, J. R.

    1980-01-01

    The primary objective of the Conservation of Strategic Aerospace Materials (COSAM) Program is to help reduce the dependence of the United States aerospace industry on strategic metals by providing the materials technology needed to minimize the strategic metal content of critical aerospace components with prime emphasis on components for gas turbine engines. Initial emphasis was placed in the area of strategic element substinction. Specifically, the role of cobalt in nickel base and cobalt base superalloys vital to the aerospace industry is being examined in great detail by means of cooperative university-industry-government research efforts. Investigations are underway in the area of "new classes" of alloys. Specifically, a study was undertaken to investigate the mechanical and physical properties of intermetallics that contain a minimum of the strategic metals. Current plans for the much larger COSAM Program are also presented.

  17. The influence of the computational mesh on accuracy for initial value problems with discontinuous or nonunique solutions. [for wave, Burger and Euler equations

    NASA Technical Reports Server (NTRS)

    Maccormack, R. W.; Paullay, A. J.

    1974-01-01

    Discontinuous, or weak, solutions of the wave equation, the inviscid form of Burgers equation, and the time-dependent, two-dimensional Euler equations are studied. A numerical method of second-order accuracy in two forms, differential and integral, is used to calculate the weak solutions of these equations for several initial value problems, including supersonic flow past a wedge, a double symmetric wedge, and a sphere. The effect of the computational mesh on the accuracy of computed weak solutions including shock waves and expansion phenomena is studied. Modifications to the finite-difference method are presented which aid in obtaining desired solutions for initial value problems in which the solutions are nonunique.

  18. NASA strategic plan

    NASA Technical Reports Server (NTRS)

    1994-01-01

    The NASA Strategic Plan is a living document. It provides far-reaching goals and objectives to create stability for NASA's efforts. The Plan presents NASA's top-level strategy: it articulates what NASA does and for whom; it differentiates between ends and means; it states where NASA is going and what NASA intends to do to get there. This Plan is not a budget document, nor does it present priorities for current or future programs. Rather, it establishes a framework for shaping NASA's activities and developing a balanced set of priorities across the Agency. Such priorities will then be reflected in the NASA budget. The document includes vision, mission, and goals; external environment; conceptual framework; strategic enterprises (Mission to Planet Earth, aeronautics, human exploration and development of space, scientific research, space technology, and synergy); strategic functions (transportation to space, space communications, human resources, and physical resources); values and operating principles; implementing strategy; and senior management team concurrence.

  19. Thinking strategically about capitation.

    PubMed

    Boland, P

    1997-05-01

    All managed care stakeholders--health plan members, employers, providers, community organizations, and government entitites--share a common interest in reducing healthcare costs while improving the quality of care health plan members receive. Although capitation is a usually thought of primarily as a payment mechanism, it can be a powerful tool providers and health plans can use to accomplish these strategic objectives and others, such as restoring and maintaining the health of plan members or improving a community's health status. For capitation to work effectively as a strategic tool, its use must be tied to a corporate agenda of partnering with stakeholders to achieve broader strategic goals. Health plans and providers must develop a partnership strategy in which each stakeholder has well-defined roles and responsibilities. The capitation structure must reinforce interdependence, shift focus from meeting organizational needs to meeting customer needs, and develop risk-driven care strategies.

  20. The Strategic Attitude: Integrating Strategic Planning into Daily University Worklife

    ERIC Educational Resources Information Center

    Dickmeyer, Nathan

    2004-01-01

    Chief financial officers in today's universities are so busy with the challenges of day-to-day management that strategic thinking often takes a back seat. Planning for strategic change can go a long way toward streamlining the very daily tasks that obscure the "big picture." Learning how to integrate strategic thinking into day-to-day management…

  1. The Strategic Attitude: Integrating Strategic Planning into Daily University Worklife

    ERIC Educational Resources Information Center

    Dickmeyer, Nathan

    2004-01-01

    Chief financial officers in today's universities are so busy with the challenges of day-to-day management that strategic thinking often takes a back seat. Planning for strategic change can go a long way toward streamlining the very daily tasks that obscure the "big picture." Learning how to integrate strategic thinking into day-to-day management…

  2. Strategic avionics technology planning

    NASA Astrophysics Data System (ADS)

    Cox, Kenneth J.; Brown, Don C.

    NASA experience in development and insertion of technology into programs had led to a recognition that a Strategic Plan for Avionics is needed for space. In the fall of 1989 an Avionics Technology Symposium was held in Williamsburg, Virginia. In early 1990, as a followon, a NASA wide Strategic Avionics Technology Working Group was chartered by NASA Headquarters. This paper will describe the objectives of this working group, technology bridging, and approaches to incentivize both the federal and commercial sectors to move toward rapidly developed, simple, and reliable systems with low life cycle cost.

  3. On operator strategic behavior

    NASA Technical Reports Server (NTRS)

    Hancock, P. A.

    1991-01-01

    Deeper and more detailed knowledge as to how human operators such as pilots respond, singly and in groups, to demands on their performance which arise from technical systems will support the manipulation of such systems' design in order to accommodate the foibles of human behavior. Efforts to understand how self-autonomy impacts strategic behavior and such related issues as error generation/recognition/correction are still in their infancy. The present treatment offers both general and aviation-specific definitions of strategic behavior as precursors of prospective investigations.

  4. Strategic avionics technology planning

    NASA Technical Reports Server (NTRS)

    Cox, Kenneth J.; Brown, Don C.

    1991-01-01

    NASA experience in development and insertion of technology into programs had led to a recognition that a Strategic Plan for Avionics is needed for space. In the fall of 1989 an Avionics Technology Symposium was held in Williamsburg, Virginia. In early 1990, as a followon, a NASA wide Strategic Avionics Technology Working Group was chartered by NASA Headquarters. This paper will describe the objectives of this working group, technology bridging, and approaches to incentivize both the federal and commercial sectors to move toward rapidly developed, simple, and reliable systems with low life cycle cost.

  5. On operator strategic behavior

    NASA Technical Reports Server (NTRS)

    Hancock, P. A.

    1991-01-01

    Deeper and more detailed knowledge as to how human operators such as pilots respond, singly and in groups, to demands on their performance which arise from technical systems will support the manipulation of such systems' design in order to accommodate the foibles of human behavior. Efforts to understand how self-autonomy impacts strategic behavior and such related issues as error generation/recognition/correction are still in their infancy. The present treatment offers both general and aviation-specific definitions of strategic behavior as precursors of prospective investigations.

  6. Microgravity strategic planning exercise

    NASA Technical Reports Server (NTRS)

    Halpern, Richard; Downey, Jim; Harvey, Harold

    1991-01-01

    The Center for Space and Advanced Technology supported a planning exercise for the Microgravity Program management at the Marshall Space Flight Center. The effort focused on the status of microgravity work at MSFC and elsewhere with the objective of preparing a goal-oriented strategic planning document which could be used for informational/brochure purposes. The effort entailed numerous interactions and presentations with Field Center programmatic components and Headquarters personnel. Appropriate material was consolidated in a draft format for a MSFC Strategic Plan.

  7. Strategic avionics technology planning

    NASA Technical Reports Server (NTRS)

    Cox, Kenneth J.; Brown, Don C.

    1991-01-01

    NASA experience in development and insertion of technology into programs had led to a recognition that a Strategic Plan for Avionics is needed for space. In the fall of 1989 an Avionics Technology Symposium was held in Williamsburg, Virginia. In early 1990, as a followon, a NASA wide Strategic Avionics Technology Working Group was chartered by NASA Headquarters. This paper will describe the objectives of this working group, technology bridging, and approaches to incentivize both the federal and commercial sectors to move toward rapidly developed, simple, and reliable systems with low life cycle cost.

  8. Clean Energy Manufacturing Initiative

    SciTech Connect

    2013-04-01

    The initiative will strategically focus and rally EERE’s clean energy technology offices and Advanced Manufacturing Office around the urgent competitive opportunity for the United States to be the leader in the clean energy manufacturing industries and jobs of today and tomorrow.

  9. Strategic Management in the Community College.

    ERIC Educational Resources Information Center

    Myran, Gunder A.

    1983-01-01

    Defines strategic management and discusses its role in community colleges, focusing on the components and methodology of strategic management, strategic and operational management function, management teams, and the need for strategic management. (DMM)

  10. A Handbook for Strategic Planning

    DTIC Science & Technology

    1994-01-01

    This handbook was written for Department of the Navy (DON) commanding officers, TQL coordinators, and strategic planning facilitators in response to...questions about the strategic planning process and how it should be conducted within the DON. It is not intended to teach the intricacies of strategic ... planning , but is provided to answer process questions. While every question cannot be anticipated, the handbook details one way to do strategic

  11. Taking a 'Byte' out of the New Computer Induced Cultural Imperialism: A Report of an Australian Initiative.

    ERIC Educational Resources Information Center

    Sungaila, H. M.; Shorten, A. R.

    This paper proposes the idea that in smaller countries, such as Australia and New Zealand, computer-assisted education may be creating an era of neo-colonialism in education. The paper discusses the problems of attempting to develop and maintain intellectual and cultural independence in an age of high technology. In countries such as Australia…

  12. Assessing Learners' Perceived Readiness for Computer-Supported Collaborative Learning (CSCL): A Study on Initial Development and Validation

    ERIC Educational Resources Information Center

    Xiong, Yao; So, Hyo-Jeong; Toh, Yancy

    2015-01-01

    The main purpose of this study was to develop an instrument that assesses university students' perceived readiness for computer-supported collaborative learning (CSCL). Assessment in CSCL research had predominantly focused on measuring "after-collaboration" outcomes and "during-collaboration" behaviors while…

  13. Assessing Learners' Perceived Readiness for Computer-Supported Collaborative Learning (CSCL): A Study on Initial Development and Validation

    ERIC Educational Resources Information Center

    Xiong, Yao; So, Hyo-Jeong; Toh, Yancy

    2015-01-01

    The main purpose of this study was to develop an instrument that assesses university students' perceived readiness for computer-supported collaborative learning (CSCL). Assessment in CSCL research had predominantly focused on measuring "after-collaboration" outcomes and "during-collaboration" behaviors while…

  14. The Possibilities of Strategic Finance

    ERIC Educational Resources Information Center

    Chaffee, Ellen

    2010-01-01

    Strategic finance is aligning financial decisions--regarding revenues, creating and maintaining institutional assets, and using those assets--with the institution's mission and strategic plan. The concept known as "strategic finance" increasingly is being seen as a useful perspective for helping boards and presidents develop a sustainable…

  15. Strategic Planning and Financial Management

    ERIC Educational Resources Information Center

    Conneely, James F.

    2010-01-01

    Strong financial management is a strategy for strategic planning success in student affairs. It is crucial that student affairs professionals understand the necessity of linking their strategic planning with their financial management processes. An effective strategic planner needs strong financial management skills to implement the plan over…

  16. Being Strategic in HE Management

    ERIC Educational Resources Information Center

    West, Andrew

    2008-01-01

    The call to be strategic--and with it the concept of strategic management--can bring to mind a wide range of definitions, and there is now a huge array of academic literature supporting the different schools of thought. At a basic level, however, strategic thinking is probably most simply about focusing on the whole, rather than the part. In…

  17. Strategic Partnerships in Higher Education

    ERIC Educational Resources Information Center

    Ortega, Janet L.

    2013-01-01

    The purpose of this study was to investigate the impacts of strategic partnerships between community colleges and key stakeholders; to specifically examine strategic partnerships; leadership decision-making; criteria to evaluate strategic partnerships that added value to the institution, value to the students, faculty, staff, and the local…

  18. The Possibilities of Strategic Finance

    ERIC Educational Resources Information Center

    Chaffee, Ellen

    2010-01-01

    Strategic finance is aligning financial decisions--regarding revenues, creating and maintaining institutional assets, and using those assets--with the institution's mission and strategic plan. The concept known as "strategic finance" increasingly is being seen as a useful perspective for helping boards and presidents develop a sustainable…

  19. Strategic Planning and Financial Management

    ERIC Educational Resources Information Center

    Conneely, James F.

    2010-01-01

    Strong financial management is a strategy for strategic planning success in student affairs. It is crucial that student affairs professionals understand the necessity of linking their strategic planning with their financial management processes. An effective strategic planner needs strong financial management skills to implement the plan over…

  20. Being Strategic in HE Management

    ERIC Educational Resources Information Center

    West, Andrew

    2008-01-01

    The call to be strategic--and with it the concept of strategic management--can bring to mind a wide range of definitions, and there is now a huge array of academic literature supporting the different schools of thought. At a basic level, however, strategic thinking is probably most simply about focusing on the whole, rather than the part. In…