Testing pathways linking exposure to community violence and sexual behaviors among African American youth.

PubMed

Voisin, Dexter R; Hotton, Anna L; Neilands, Torsten B

2014-09-01

Exposure to community violence and HIV sexual risks are two major public health concerns among youth. This study tests various pathways linking exposure to community violence and sexual behaviors among African American adolescents. Using a sample of 563 (61% females) African American youth attending high school we examined whether problematic psychological symptoms, low school engagement, and/or negative perceptions of peer norms about safer sex functioned as pathways linking exposure to community violence and sexual behaviors. Major findings indicated that, for boys, the relationship between exposure to community violence and sexual début and sexual risk behaviors were linked by aggression. In addition, the relationship between exposure to community violence and sexual risk behaviors were linked by negative perceptions of peer attitudes about safer sex. For girls, the relationship between exposure to community violence and sexual début was linked by aggression and negative perceptions of peer attitudes about safer sex. These findings provide support for pathways linking exposure to community violence to sexual behaviors.

Testing Pathways Linking Exposure to Community Violence and Sexual Behaviors Among African American Youth

PubMed Central

Hotton, Anna L.; Neilands, Torsten B.

2014-01-01

Exposure to community violence and HIV sexual risks are two major public health concerns among youth. This study tests various pathways linking exposure to community violence and sexual behaviors among African American adolescents. Using a sample of 563 (61 % females) African American youth attending high school we examined whether problematic psychological symptoms, low school engagement, and/or negative perceptions of peer norms about safer sex functioned as pathways linking exposure to community violence and sexual behaviors. Major findings indicated that, for boys, the relationship between exposure to community violence and sexual début and sexual risk behaviors were linked by aggression. In addition, the relationship between exposure to community violence and sexual risk behaviors were linked by negative perceptions of peer attitudes about safer sex. For girls, the relationship between exposure to community violence and sexual début was linked by aggression and negative perceptions of peer attitudes about safer sex. These findings provide support for pathways linking exposure to community violence to sexual behaviors. PMID:24327295

Entering Industry: A Case Study of Links between a School Vocational Program and the Building and Construction Industry

ERIC Educational Resources Information Center

Taylor, Anthea

2004-01-01

Few studies have tracked youth transition beyond the immediate post-school period or have looked at the longer-term outcomes of post-school programs. This study reports the findings of a case study investigating links between an industry-specific school vocational education and training (VET) program and subsequent work transitions to the building…

Longitudinal Evidence Linking Processing Speed to the Development of Reasoning

ERIC Educational Resources Information Center

Kail, Robert V.; Lervåg, Arne; Hulme, Charles

2016-01-01

Age-related change in processing speed has been linked directly to increases in reasoning as well as indirectly via increases in the capacity of working memory (WM). Most of the evidence linking change in speed to reasoning has come from cross-sectional research; in this article we present the findings from a 2½-year longitudinal study of 277 6-…

Perceived Discrimination, Peer Influence and Sexual Behaviors in Mexican American Preadolescents.

PubMed

Sanchez, Delida; Whittaker, Tiffany A; Hamilton, Emma

2016-05-01

Both discrimination and sexual health disparities have significant negative health implications for Latina/o preadolescent youth, including negative mental health outcomes, STIs/HIV, unintended pregnancy, and ongoing poverty. Studying these links within this population, therefore, has significant public health relevance, both in terms of promoting sexual health in general as well as serving the specific needs of Latina/o youth. This study explored the relationship between perceived discrimination, peer influence and sexual behaviors among 438 Mexican American preadolescents in the Southwest United States (55.3 % male). Additionally, this study examined whether psychological distress, substance use, and sexual motives mediated and whether gender moderated these relations. A multiple-group path analysis of the analytical model was performed to examine the hypothesized relations between perceived discrimination, peer influence, psychological distress, substance use, sexual motives and sexual behaviors. The findings indicated that perceived discrimination was directly linked to sexual behaviors among participants and indirectly linked via substance use. The findings also indicated that peer influence was indirectly linked to sexual behaviors via substance use among participants and via sexual motives among boys. This study underscores the importance of substance use in the perceived discrimination, peer influence and sexual behavior link in Mexican American preadolescents. Additionally, it highlights the importance of sexual motives in the link between peer influence and sexual behaviors of Mexican American boys.

Visualizing weighted networks: a performance comparison of adjacency matrices versus node-link diagrams

NASA Astrophysics Data System (ADS)

McIntire, John P.; Osesina, O. Isaac; Bartley, Cecilia; Tudoreanu, M. Eduard; Havig, Paul R.; Geiselman, Eric E.

2012-06-01

Ensuring the proper and effective ways to visualize network data is important for many areas of academia, applied sciences, the military, and the public. Fields such as social network analysis, genetics, biochemistry, intelligence, cybersecurity, neural network modeling, transit systems, communications, etc. often deal with large, complex network datasets that can be difficult to interact with, study, and use. There have been surprisingly few human factors performance studies on the relative effectiveness of different graph drawings or network diagram techniques to convey information to a viewer. This is particularly true for weighted networks which include the strength of connections between nodes, not just information about which nodes are linked to other nodes. We describe a human factors study in which participants performed four separate network analysis tasks (finding a direct link between given nodes, finding an interconnected node between given nodes, estimating link strengths, and estimating the most densely interconnected nodes) on two different network visualizations: an adjacency matrix with a heat-map versus a node-link diagram. The results should help shed light on effective methods of visualizing network data for some representative analysis tasks, with the ultimate goal of improving usability and performance for viewers of network data displays.

Temporal context, preference, and resistance to change.

PubMed

Podlesnik, Christopher A; Jimenez-Gomez, Corina; Thrailkill, Eric A; Shahan, Timothy A

2011-09-01

According to behavioral momentum theory, preference and relative resistance to change in concurrent-chains schedules are correlated and reflect the relative conditioned value of discriminative stimuli. In the present study, we explore the generality of this relation by manipulating the temporal context within a concurrent-chains procedure through changes in the duration of the initial links. Consistent with previous findings, preference for a richer terminal link was less extreme with longer initial links across three experiments with pigeons. In Experiment 1, relative resistance to change and preference were related inversely when responding was disrupted with response-independent food presentations during initial links, replicating a previous finding with rats. However, more food was presented with longer initial links, confounding the disrupter and initial-link duration. In Experiment 2, presession feeding was used instead and eliminated the negative relation between relative resistance to change and preference, but relative resistance to change was not sensitive to relative terminal-link reinforcement rates. In Experiment 3, with more extreme relative terminal-link reinforcement rates, increasing initial-link duration similarly decreased preference and relative resistance to change for the richer terminal link. Thus, when conditions of disruption are equal and assessed under the appropriate reinforcement conditions, changes in temporal context impact relative resistance to change and preference similarly.

Learning from Leadership: Investigating the Links to Improved Student Learning. The Informed Educator Series

ERIC Educational Resources Information Center

Wahlstrom, Kyla L.; Louis, Karen Seashore; Leithwood, Kenneth; Anderson, Stephen E.

2010-01-01

In a recent 334-page report, "Investigating the Links to Improved Student Learning," authors Kyla Walstrom, Karen Seashore Louis, Kenneth Leithwood, and Stephen Anderson discuss findings from the Learning from Leadership study. This study was designed to identify and describe successful educational leadership and to explain how such leadership at…

A Matter of Interpretation: Developing Primary Pupils' Enquiry Skills Using Position-Linked Datalogging

ERIC Educational Resources Information Center

Davies, Daniel John; Collier, Christopher; Howe, Alan

2012-01-01

Background: This article reports on an evaluation study of a project seeking to develop the use of position-linked datalogging with primary pupils in environmental science contexts. Purpose: The study sought to find out the extent to which the project had developed: (1) participant teachers' confidence in using datalogging as an everyday part of…

Scaling of global input-output networks

NASA Astrophysics Data System (ADS)

Liang, Sai; Qi, Zhengling; Qu, Shen; Zhu, Ji; Chiu, Anthony S. F.; Jia, Xiaoping; Xu, Ming

2016-06-01

Examining scaling patterns of networks can help understand how structural features relate to the behavior of the networks. Input-output networks consist of industries as nodes and inter-industrial exchanges of products as links. Previous studies consider limited measures for node strengths and link weights, and also ignore the impact of dataset choice. We consider a comprehensive set of indicators in this study that are important in economic analysis, and also examine the impact of dataset choice, by studying input-output networks in individual countries and the entire world. Results show that Burr, Log-Logistic, Log-normal, and Weibull distributions can better describe scaling patterns of global input-output networks. We also find that dataset choice has limited impacts on the observed scaling patterns. Our findings can help examine the quality of economic statistics, estimate missing data in economic statistics, and identify key nodes and links in input-output networks to support economic policymaking.

Problems in aerial application. II, Effects of chlorinated hydrocarbons on substrate-linked phosphorylation.

DOT National Transportation Integrated Search

1963-03-01

In a search for an explanation of an earlier finding that dieldrin decreased the rate of methionine uptake by cardiac muscle, chickens and rats were exposed to this compound and the substrate-linked phosphorylation phenomenon was studied during the a...

Linking admiration and adoration to self-expansion: different ways to enhance one's potential.

PubMed

Schindler, Ines; Paech, Juliane; Löwenbrück, Fabian

2015-01-01

How is admiration different from adoration? We provided one answer to this question by examining the pathways through which admiration and adoration linked to self-expansion in a questionnaire and an experimental (autobiographical recall of emotion episodes) study. Both emotions were associated with increased potential efficacy to accomplish goals (i.e., self-expansion), but different action tendencies accounted for these links. While our emotion inductions did not successfully distinguish between admiration and adoration, we could statistically disentangle their effects through mediator models. In both studies, self-reported admiration linked to self-expansion through the tendency to emulate admired others. Adoration related to self-expansion through the tendency to affiliate with adored others. These findings were obtained after controlling for other emotions in response to the target person (awe, love, hope, benign envy) and mutuality of the relationship. Our findings also suggest that considering specific emotions (rather than undifferentiated positive affect) helps uncover different pathways to self-expansion.

Validation Studies for Diet History Questionnaire II | EGRP/DCCPS/NCI/NIH

Cancer.gov

Links to validation findings from the original Diet History Questionnaire (DHQ). These findings are unlikely to be greatly modified by minimal modifications to DHQ II food list and the updated nutrient database.

Re-examining the link between prenatal maternal anxiety and child emotional difficulties, using a sibling design.

PubMed

Bekkhus, Mona; Lee, Yunsung; Nordhagen, Rannveig; Magnus, Per; Samuelsen, Sven O; Borge, Anne I H

2018-02-01

Prenatal exposure to maternal anxiety has been associated with child emotional difficulties in a number of epidemiological studies. One key concern, however, is that this link is vulnerable to confounding by pleiotropic genes or environmental family factors. Data on 82 383 mothers and children from the population-based Mother and Child Cohort Study and data on 21 980 siblings were used in this study. Mothers filled out questionnaires for each unique pregnancy, for infant difficulties at 6 months and for emotional difficulties at 36 months. The link between prenatal maternal anxiety and child difficulties were examined using logistic regression analyses and multiple linear regression analyses for the full study sample and the sibling sample. In the conventional full-cohort analyses, prenatal exposure to maternal anxiety was associated with child difficulties at both 6 months [odds ratio (OR) = 2.1 (1.94-2.27)] and 36 months [OR = 2.72 (2.47-2.99)]. The findings were essentially the same whether we examined difficulties at 6 months or at 36 months. However, these associations were no longer present once we controlled for potential social and genetic confounders in the sibling comparison analyses, either at 6 months [OR = 1.32 (0.91-1.90)] or at 36 months [OR = 1.28 (0.63-2.60)]. Findings from multiple regression analyses with continuous measures were essentially the same. Our finding lends little support for there being an independent prenatal effect on child emotional difficulties; rather, our findings suggest that the link between prenatal maternal anxiety and child difficulties could be confounded by pleiotropic genes or environmental family factors. © The Author 2017; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association

Linking Professional, School, Demographic, and Motivational Factors to Desire for Principalship

ERIC Educational Resources Information Center

Walker, Allan; Kwan, Paula

2009-01-01

Purpose: This study attempts to link four groups of contextual factors to vice principals' desire for principalship using regression analysis. Relevant items representing context are grouped under professional, school, demographic, and motivational factors. The findings aim to provide greater understanding of the desire, or lack thereof, of vice…

Household Chaos--Links with Parenting and Child Behaviour

ERIC Educational Resources Information Center

Coldwell, Joanne; Pike, Alison; Dunn, Judy

2006-01-01

Background: The study aimed to confirm previous findings showing links between household chaos and parenting in addition to examining whether household chaos was predictive of children's behaviour over and above parenting. In addition, we investigated whether household chaos acts as a moderator between parenting and children's behaviour. Method:…

The Link: Connecting Juvenile Justice and Child Welfare. Volume 3, Number 3, Summer/Fall 2004

ERIC Educational Resources Information Center

Child Welfare League of America (NJ-L1), 2004

2004-01-01

This issue of "The Link" newsletter contains the following articles: (1) "Youth in Foster Care Who Commit Delinquent Acts: Study Findings and Recommendations" (Leslee Morris); (2) "Director's Message" (Christy Sharp); (3) "Juvenile Justice News and Resources"; (4) "The Nurse-Family Partnership:…

Evaluating the link between self-esteem and temperament in Mexican origin early adolescents.

PubMed

Robins, Richard W; Donnellan, M Brent; Widaman, Keith F; Conger, Rand D

2010-06-01

The present study examined the relation between self-esteem and temperament in a sample of 646 Mexican-American early adolescents (mean age=10.4). Findings show that (a) early adolescents with high self-esteem exhibit higher levels of Effortful Control but, contrary to findings in adult samples, do not differ from low self-esteem adolescents in Negative Affectivity; (b) low self-esteem is associated with Depression; and (c) low self-esteem is associated with Aggression. These findings replicated for boys and girls, two measures of self-esteem, and child and mother reports of temperament. The present study contributes to an emerging understanding of the link between self-esteem and temperament, and provides much needed data on the nature of self-esteem in ethnic minority populations.

A Comparative Study of Computer-Aided Clinical Diagnosis of Birth Defects.

DTIC Science & Technology

1981-01-21

SUPPRESSIBLE HYPERPARATHYROIDISM TYPE NEONATAL FAMILIAL HYPOCHONDROPLASIA HYPOGLYCEMIA TYPE FAMILIAL NEONATAL HYPOGLYCEMIA TYPE LEUCINE INDUCED...disease. There are also causal links between disease nodes. These are unidirectional links indicating that one disease can cause the other. These links...contains the finding and has no superior which does.4 If f5 was then entered, D8 and D9 would quality to be evoked. This would cause D1 to be deactivated

Revealing the Link between Structural Relaxation and Dynamic Heterogeneity in Glass-Forming Liquids

NASA Astrophysics Data System (ADS)

Wang, Lijin; Xu, Ning; Wang, W. H.; Guan, Pengfei

2018-03-01

Despite the use of glasses for thousands of years, the nature of the glass transition is still mysterious. On approaching the glass transition, the growth of dynamic heterogeneity has long been thought to play a key role in explaining the abrupt slowdown of structural relaxation. However, it still remains elusive whether there is an underlying link between structural relaxation and dynamic heterogeneity. Here, we unravel the link by introducing a characteristic time scale hiding behind an identical dynamic heterogeneity for various model glass-forming liquids. We find that the time scale corresponds to the kinetic fragility of liquids. Moreover, it leads to scaling collapse of both the structural relaxation time and dynamic heterogeneity for all liquids studied, together with a characteristic temperature associated with the same dynamic heterogeneity. Our findings imply that studying the glass transition from the viewpoint of dynamic heterogeneity is more informative than expected.

Bidirectional Associations Among Sensitive Parenting, Language Development, and Social Competence

PubMed Central

Barnett, Melissa A.; Gustafsson, Hanna; Deng, Min; Mills-Koonce, W. Roger; Cox, Martha

2014-01-01

Rapid changes in language skills and social competence, both of which are linked to sensitive parenting, characterize early childhood. The present study examines bidirectional associations among mothers’ sensitive parenting and children’s language skills and social competence from 24 to 36 months in a community sample of 174 families. In addition, this study examines how these developmental pathways vary by child sex. Findings indicate stability across time in sensitive parenting, expressive language skills, and social competence, as well as positive main effects of sensitive parenting on expressive and receptive language skills for girls and boys. We find mixed evidence over time of reciprocal links between social competence and sensitive parenting. Further, boys’ receptive language skills at 24 months uniquely contribute to increases in mothers’ observed sensitive parenting from 24 to 36 months. These findings highlight the utility of applying transactional frameworks to the study of sex-based differences in early developmental processes. PMID:25126021

Two genetic markers closely linked to adult polycystic kidney disease on chromosome 16.

PubMed Central

Reeders, S T; Breuning, M H; Corney, G; Jeremiah, S J; Meera Khan, P; Davies, K E; Hopkinson, D A; Pearson, P L; Weatherall, D J

1986-01-01

The genetic locus for autosomal dominant adult polycystic kidney disease was recently assigned to chromosome 16 by the finding of genetic linkage to the alpha globin gene cluster. Further study showed that the phosphoglycolate phosphatase locus is also closely linked to both the locus for adult polycystic kidney disease and the alpha globin gene cluster. These findings have important implications for the prenatal and presymptomatic diagnosis of adult polycystic kidney disease and for a better understanding of its pathogenesis. Images FIG 1 PMID:3008903

Parental rearing style: examining for links with personality vulnerability factors for depression.

PubMed

Parker, G

1993-07-01

Recent research provides evidence of links between anomalous parenting experiences in childhood and subsequent depression. A study was designed to pursue the possibility that anomalous parenting effects a diathesis to depression by inducing a vulnerable cognitive style rather than by disposing directly to depression. Possible mediating personality style variables were explored in a study of 123 depressed subjects who scored their parents on the Parental Bonding Instrument (PBI), as well as completing a state depression and several relevant personality measures. Low self-esteem and a related dysfunction cognitive style were the personality variables most clearly linked with PBI scores, with links persisting after partialling out state levels of depression. Failure to find links between PBI scores and depression levels limited explication of the diathesis stress model.

Living in Partner-Violent Families: Developmental Links to Antisocial Behavior and Relationship Violence

ERIC Educational Resources Information Center

Ireland, Timothy O.; Smith, Carolyn A.

2009-01-01

Links between living in a partner-violent home and subsequent aggressive and antisocial behavior are suggested by the "cycle of violence" hypothesis derived from social learning theory. Although there is some empirical support, to date, findings have been generally limited to cross-sectional studies predominantly of young children, or…

Aggressive behavior and its associations with posttraumatic stress and academic achievement following a natural disaster.

PubMed

Scott, Brandon G; Lapré, Genevieve E; Marsee, Monica A; Weems, Carl F

2014-01-01

Despite an abundance of evidence linking maltreatment and violence-related trauma exposure to externalizing problems in youth, there is surprisingly little evidence to support a direct link between disaster exposure and youth aggressive behavior. This study tested the theory that there is primarily an indirect association between disaster exposure and aggression via posttraumatic stress disorder (PTSD) symptoms. The current study also examined the association between aggression and academic achievement. A sample of 191 4th- to 8th-grade minority youth who experienced Hurricane Katrina were assessed for aggressive behavior using the Peer Conflict Scale (PCS), disaster exposure, PTSD symptoms, and academic achievement. Structural equation modeling of the set of associations was consistent with the theory suggesting that there is an indirect link between disaster exposure and aggression through PTSD symptoms. Aggression was negatively associated with academic achievement, and modeling indicated that the set of associations was age and gender invariant. Findings advance the theoretical understanding of the linkage between aggression and disaster exposure. Findings also support the utility of the PCS in disaster research and the link between PCS scores and academic achievement.

Identification of hybrid node and link communities in complex networks

PubMed Central

He, Dongxiao; Jin, Di; Chen, Zheng; Zhang, Weixiong

2015-01-01

Identifying communities in complex networks is an effective means for analyzing complex systems, with applications in diverse areas such as social science, engineering, biology and medicine. Finding communities of nodes and finding communities of links are two popular schemes for network analysis. These schemes, however, have inherent drawbacks and are inadequate to capture complex organizational structures in real networks. We introduce a new scheme and an effective approach for identifying complex mixture structures of node and link communities, called hybrid node-link communities. A central piece of our approach is a probabilistic model that accommodates node, link and hybrid node-link communities. Our extensive experiments on various real-world networks, including a large protein-protein interaction network and a large network of semantically associated words, illustrated that the scheme for hybrid communities is superior in revealing network characteristics. Moreover, the new approach outperformed the existing methods for finding node or link communities separately. PMID:25728010

Identification of hybrid node and link communities in complex networks.

PubMed

He, Dongxiao; Jin, Di; Chen, Zheng; Zhang, Weixiong

2015-03-02

Identifying communities in complex networks is an effective means for analyzing complex systems, with applications in diverse areas such as social science, engineering, biology and medicine. Finding communities of nodes and finding communities of links are two popular schemes for network analysis. These schemes, however, have inherent drawbacks and are inadequate to capture complex organizational structures in real networks. We introduce a new scheme and an effective approach for identifying complex mixture structures of node and link communities, called hybrid node-link communities. A central piece of our approach is a probabilistic model that accommodates node, link and hybrid node-link communities. Our extensive experiments on various real-world networks, including a large protein-protein interaction network and a large network of semantically associated words, illustrated that the scheme for hybrid communities is superior in revealing network characteristics. Moreover, the new approach outperformed the existing methods for finding node or link communities separately.

Identification of hybrid node and link communities in complex networks

NASA Astrophysics Data System (ADS)

He, Dongxiao; Jin, Di; Chen, Zheng; Zhang, Weixiong

2015-03-01

Identifying communities in complex networks is an effective means for analyzing complex systems, with applications in diverse areas such as social science, engineering, biology and medicine. Finding communities of nodes and finding communities of links are two popular schemes for network analysis. These schemes, however, have inherent drawbacks and are inadequate to capture complex organizational structures in real networks. We introduce a new scheme and an effective approach for identifying complex mixture structures of node and link communities, called hybrid node-link communities. A central piece of our approach is a probabilistic model that accommodates node, link and hybrid node-link communities. Our extensive experiments on various real-world networks, including a large protein-protein interaction network and a large network of semantically associated words, illustrated that the scheme for hybrid communities is superior in revealing network characteristics. Moreover, the new approach outperformed the existing methods for finding node or link communities separately.

Unified Multimodal Measurement for Performance Indication Research, Evaluation, and Effectiveness (UMMPIREE): Phase I Report

DTIC Science & Technology

2018-01-25

generally a researcher into methods and techniques (i.e., the science) of assessment. This stakeholder may observe ongoing events/experiments or may use... Research Visualization Tool. A first step toward finding a method to link research . 3.1.2 Phase II: Linking and the Network Approach During Phase I, we...innovations. In the former realm, UMMPIREE will develop a method to link assessments from different research studies to guide research

Combating the sting of rejection with the pleasure of revenge: A new look at how emotion shapes aggression.

PubMed

Chester, David S; DeWall, C Nathan

2017-03-01

How does emotion explain the relationship between social rejection and aggression? Rejection reliably damages mood, leaving individuals motivated to repair their negatively valenced affective state. Retaliatory aggression is often a pleasant experience. Rejected individuals may then harness revenge's associated positive affect to repair their mood. Across 6 studies (total N = 1,516), we tested the prediction that the rejection-aggression link is motivated by expected and actual mood repair. Further, we predicted that this mood repair would occur through the positive affect of retaliatory aggression. Supporting these predictions, naturally occurring (Studies 1 and 2) and experimentally manipulated (Studies 3 and 4) motives to repair mood via aggression moderated the rejection-aggression link. These effects were mediated by sadistic impulses toward finding aggression pleasant (Studies 2 and 4). Suggesting the occurrence of actual mood repair, rejected participants' affective states were equivalent to their accepted counterparts after an act of aggression (Studies 5 and 6). This mood repair occurred through a dynamic interplay between preaggression affect and aggression itself, and was driven by increases in positive affect (Studies 5 and 6). Together, these findings suggest that the rejection-aggression link is driven, in part, by the desire to return to affective homeostasis. Additionally, these findings implicate aggression's rewarding nature as an incentive for rejected individuals' violent tendencies. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Cycling through the Blues: The Impact of Systemic External Stressors on Student Mental States and Symptoms of Depression

ERIC Educational Resources Information Center

Goldring, Michelle A.

2012-01-01

This study seeks to find if the structure of the demands of the quarter system impacts the levels of depression reported in the school's student body. That is, can the external and systemic stressors at be linked to levels of depressive symptoms? This study proposes that depressive symptoms may be linked to external stresses exerted on the student…

Effect of the G375C and G346E achondroplasia mutations on FGFR3 activation.

PubMed

He, Lijuan; Serrano, Christopher; Niphadkar, Nitish; Shobnam, Nadia; Hristova, Kalina

2012-01-01

Two mutations in FGFR3, G380R and G375C are known to cause achondroplasia, the most common form of human dwarfism. The G380R mutation accounts for 98% of the achondroplasia cases, and thus has been studied extensively. Here we study the effect of the G375C mutation on the phosphorylation and the cross-linking propensity of full-length FGFR3 in HEK 293 cells, and we compare the results to previously published results for the G380R mutant. We observe identical behavior of the two achondroplasia mutants in these experiments, a finding which supports a direct link between the severity of dwarfism phenotypes and the level and mechanism of FGFR3 over-activation. The mutations do not increase the cross-linking propensity of FGFR3, contrary to previous expectations that the achondroplasia mutations stabilize the FGFR3 dimers. Instead, the phosphorylation efficiency within un-liganded FGFR3 dimers is increased, and this increase is likely the underlying cause for pathogenesis in achondroplasia. We further investigate the G346E mutation, which has been reported to cause achondroplasia in one case. We find that this mutation does not increase FGFR3 phosphorylation and decreases FGFR3 cross-linking propensity, a finding which raises questions whether this mutation is indeed a genetic cause for human dwarfism.

Effect of the G375C and G346E Achondroplasia Mutations on FGFR3 Activation

PubMed Central

He, Lijuan; Serrano, Christopher; Niphadkar, Nitish; Shobnam, Nadia; Hristova, Kalina

2012-01-01

Two mutations in FGFR3, G380R and G375C are known to cause achondroplasia, the most common form of human dwarfism. The G380R mutation accounts for 98% of the achondroplasia cases, and thus has been studied extensively. Here we study the effect of the G375C mutation on the phosphorylation and the cross-linking propensity of full-length FGFR3 in HEK 293 cells, and we compare the results to previously published results for the G380R mutant. We observe identical behavior of the two achondroplasia mutants in these experiments, a finding which supports a direct link between the severity of dwarfism phenotypes and the level and mechanism of FGFR3 over-activation. The mutations do not increase the cross-linking propensity of FGFR3, contrary to previous expectations that the achondroplasia mutations stabilize the FGFR3 dimers. Instead, the phosphorylation efficiency within un-liganded FGFR3 dimers is increased, and this increase is likely the underlying cause for pathogenesis in achondroplasia. We further investigate the G346E mutation, which has been reported to cause achondroplasia in one case. We find that this mutation does not increase FGFR3 phosphorylation and decreases FGFR3 cross-linking propensity, a finding which raises questions whether this mutation is indeed a genetic cause for human dwarfism. PMID:22529939

Linking microbial community structure and microbial processes: An empirical and conceptual overview

USGS Publications Warehouse

Bier, R.L.; Bernhardt, Emily S.; Boot, Claudia M.; Graham, Emily B.; Hall, Edward K.; Lennon, Jay T.; Nemergut, Diana R.; Osborne, Brooke B.; Ruiz-Gonzalez, Clara; Schimel, Joshua P.; Waldrop, Mark P.; Wallenstein, Matthew D.

2015-01-01

A major goal of microbial ecology is to identify links between microbial community structure and microbial processes. Although this objective seems straightforward, there are conceptual and methodological challenges to designing studies that explicitly evaluate this link. Here, we analyzed literature documenting structure and process responses to manipulations to determine the frequency of structure-process links and whether experimental approaches and techniques influence link detection. We examined nine journals (published 2009–13) and retained 148 experimental studies measuring microbial community structure and processes. Many qualifying papers (112 of 148) documented structure and process responses, but few (38 of 112 papers) reported statistically testing for a link. Of these tested links, 75% were significant and typically used Spearman or Pearson's correlation analysis (68%). No particular approach for characterizing structure or processes was more likely to produce significant links. Process responses were detected earlier on average than responses in structure or both structure and process. Together, our findings suggest that few publications report statistically testing structure-process links. However, when links are tested for they often occur but share few commonalities in the processes or structures that were linked and the techniques used for measuring them.

Cross-linked polyethylene does not reduce wear in total knee arthroplasty.

PubMed

Lasurt-Bachs, S; Torner, P; Maculé, F; Prats, E; Menéndez-García, F; Ríos-Guillermo, J; Torrents, A

To compare two different types of inserts: Ultra-high molecular weight polyethylene (UHMWPE) and cross-linked polyethylene with a quantitative and qualitative study of polyethylene wear particles in synovial fluid 3 years after total knee arthroplasty. A prospective, randomized, controlled cohort study with blinded evaluation was carried out on 25 patients undergoing staged bilateral total knee replacement, 6 months apart. Knee arthrocentesis was performed on 12 patients 3 years after surgery, and the polyethylene particles were analyzed. No significant differences were found in the number of particles generated by the two different types of inserts at 3 years from total knee arthroplasty (3,000×: x¯ cross-linked=849.7; x¯ UHMWPE=796.9; P=.63; 20,000×: x¯ cross-linked=66.3; x¯ UHMWPE=73.1; P=.76). Likewise, no differences in the probability of finding elongated (χ 2 =0.19; P=.66) or rounded (χ 2 =1.44; P=.23) particles in both types of inserts were observed. However, the probability of finding fibrillar particles is 3.08 times greater in UHMWPE. Cross-linked polyethylene does not significantly reduce the generation of polyethylene particles in patients with total knee arthroplasty, 3 years after the surgical procedure. Copyright © 2018 SECOT. Publicado por Elsevier España, S.L.U. All rights reserved.

Social Relatedness and Physical Health Are More Strongly Related in Older Than Younger Adults: Findings from the Korean Adult Longitudinal Study

PubMed Central

Choi, Eunsoo; Kwon, Yuri; Lee, Minha; Choi, Jongan; Choi, Incheol

2018-01-01

Previous research indicates that social relatedness is beneficial to physical health; however, findings on the relative strength of the relationship between these variables have been inconsistent. The present study employed cross-sectional survey (Study 1) and a daily diary survey (Study 2) to examine the link between social relatedness and physical health by age. Using a representative sample of Korean adults (N = 371) aged from 20 to 69, Study 1 examines the link between social relatedness (loneliness, perceived social support) and physical health (physical symptoms, chronic health conditions) using age as a moderator. The results show that participants' age moderates the association between social relatedness and physical health. Study 2 (N = 384) further corroborated the findings from Study 1 by showing that when controlling for the physical symptoms experienced prior to the daily diary reports, the level of loneliness experienced over a 13-day period exacerbates the age differences in the physical symptoms. The present study thus provides converging evidence that social relatedness plays a significant role in physical health, particularly in the older population. PMID:29403415

Linking Qualifications and the Labour Market through Capabilities and Vocational Streams. Synthesis Report

ERIC Educational Resources Information Center

Wheelahan, Leesa; Buchanan, John; Yu, Serena

2015-01-01

This is the final report in the three-year program of research "Vocations: The Link between Post-Compulsory Education and the Labour Market," which investigated the educational and occupational paths people take and how their study relates to their work. This report synthesises the findings of the three different strands: pathways from…

Prediction of missing links and reconstruction of complex networks

NASA Astrophysics Data System (ADS)

Zhang, Cheng-Jun; Zeng, An

2016-04-01

Predicting missing links in complex networks is of great significance from both theoretical and practical point of view, which not only helps us understand the evolution of real systems but also relates to many applications in social, biological and online systems. In this paper, we study the features of different simple link prediction methods, revealing that they may lead to the distortion of networks’ structural and dynamical properties. Moreover, we find that high prediction accuracy is not definitely corresponding to a high performance in preserving the network properties when using link prediction methods to reconstruct networks. Our work highlights the importance of considering the feedback effect of the link prediction methods on network properties when designing the algorithms.

Web accessibility support for visually impaired users using link content analysis.

PubMed

Iwata, Hajime; Kobayashi, Naofumi; Tachibana, Kenji; Shirogane, Junko; Fukazawa, Yoshiaki

2013-12-01

Web pages are used for a variety of purposes. End users must understand dynamically changing content and sequentially follow page links to find desired material, requiring significant time and effort. However, for visually impaired users using screen readers, it can be difficult to find links to web pages when link text and alternative text descriptions are inappropriate. Our method supports the discovery of content by analyzing 8 categories of link types, and allows visually impaired users to be aware of the content represented by links in advance. This facilitates end users access to necessary information on web pages. Our method of classifying web page links is therefore effective as a means of evaluating accessibility.

Robust, Causal, and Incremental Approaches to Investigating Linguistic Adaptation

PubMed Central

Roberts, Seán G.

2018-01-01

This paper discusses the maximum robustness approach for studying cases of adaptation in language. We live in an age where we have more data on more languages than ever before, and more data to link it with from other domains. This should make it easier to test hypotheses involving adaptation, and also to spot new patterns that might be explained by adaptation. However, there is not much discussion of the overall approach to research in this area. There are outstanding questions about how to formalize theories, what the criteria are for directing research and how to integrate results from different methods into a clear assessment of a hypothesis. This paper addresses some of those issues by suggesting an approach which is causal, incremental and robust. It illustrates the approach with reference to a recent claim that dry environments select against the use of precise contrasts in pitch. Study 1 replicates a previous analysis of the link between humidity and lexical tone with an alternative dataset and finds that it is not robust. Study 2 performs an analysis with a continuous measure of tone and finds no significant correlation. Study 3 addresses a more recent analysis of the link between humidity and vowel use and finds that it is robust, though the effect size is small and the robustness of the measurement of vowel use is low. Methodological robustness of the general theory is addressed by suggesting additional approaches including iterated learning, a historical case study, corpus studies, and studying individual speech. PMID:29515487

Associations among bullying, cyberbullying, and suicide in high school students.

PubMed

Bauman, Sheri; Toomey, Russell B; Walker, Jenny L

2013-04-01

This study examined associations among depression, suicidal behaviors, and bullying and victimization experiences in 1491 high school students using data from the 2009 Youth Risk Behavior Survey. Results demonstrated that depression mediated the association between bullying/victimization and suicide attempts, but differently for males and females. Specifically, depression mediated the link between traditional victimization and suicide attempts similarly across gender, whereas depression mediated the link between cyber victimization and suicide attempts only for females. Similarly, depression mediated the link between traditional bullying and suicide attempts for females only. Depression did not mediate the link between cyberbullying and suicide attempts for either gender. Implications of the findings are discussed, including the importance of greater detection of depression among students involved in bullying, and the need for a suicide prevention and intervention component in anti-bullying programs. Findings suggest that bullying prevention efforts be extended from middle school students to include high school students. Copyright © 2012 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

A review of parenting and adolescent sexual behavior: The moderating role of gender

PubMed Central

Kincaid, Carlye; Jones, Deborah J.; Sterrett, Emma; McKee, Laura

2013-01-01

In spite of the established link between parenting and adolescent sexual risk behavior, less is known about the role of adolescent gender as a potential moderator of this association. This literature review integrates findings from 24 studies to examine gender as a moderator of the link between parenting and youth sexual risk behavior. Despite the wide variability in methodology across the reviewed studies, findings suggest that monitoring may be more protective against sexual risk behavior for boys than girls, whereas parental warmth and emotional connection may be an especially salient factor for girls. The results of this review support further research on gender as an important factor in better understanding the role of parenting in the development of adolescent sexual behavior. Furthermore, the findings highlight the potential role of gender-specific, tailored family-focused prevention programs targeting sexual behavior. PMID:22366393

A review of parenting and adolescent sexual behavior: the moderating role of gender.

PubMed

Kincaid, Carlye; Jones, Deborah J; Sterrett, Emma; McKee, Laura

2012-04-01

In spite of the established link between parenting and adolescent sexual risk behavior, less is known about the role of adolescent gender as a potential moderator of this association. This literature review integrates findings from 24 studies to examine gender as a moderator of the link between parenting and youth sexual risk behavior. Despite the wide variability in methodology across the reviewed studies, findings suggest that monitoring may be more protective against sexual risk behavior for boys than girls, whereas parental warmth and emotional connection may be an especially salient factor for girls. The results of this review support further research on gender as an important factor in better understanding the role of parenting in the development of adolescent sexual behavior. Furthermore, the findings highlight the potential role of gender-specific, tailored family-focused prevention programs targeting sexual behavior. Copyright © 2012 Elsevier Ltd. All rights reserved.

No meditation-related changes in the auditory N1 during first-time meditation.

PubMed

Barnes, L J; McArthur, G M; Biedermann, B A; de Lissa, P; Polito, V; Badcock, N A

2018-05-01

Recent studies link meditation expertise with enhanced low-level attention, measured through auditory event-related potentials (ERPs). In this study, we tested the reliability and validity of a recent finding that the N1 ERP in first-time meditators is smaller during meditation than non-meditation - an effect not present in long-term meditators. In the first experiment, we replicated the finding in first-time meditators. In two subsequent experiments, we discovered that this finding was not due to stimulus-related instructions, but was explained by an effect of the order of conditions. Extended exposure to the same tones has been linked with N1 decrement in other studies, and may explain N1 decrement across our two conditions. We give examples of existing meditation and ERP studies that may include similar condition order effects. The role of condition order among first-time meditators in this study indicates the importance of counterbalancing meditation and non-mediation conditions in meditation studies that use event-related potentials. Copyright © 2018 Elsevier B.V. All rights reserved.

Influence of cross-link structure, density and mechanical properties in the mesoscale deformation mechanisms of collagen fibrils

PubMed Central

Depalle, Baptiste; Qin, Zhao; Shefelbine, Sandra J.; Buehler, Markus J.

2015-01-01

Collagen is a ubiquitous protein with remarkable mechanical properties. It is highly elastic, shows large fracture strength and enables substantial energy dissipation during deformation. Most of the connective tissue in humans consists of collagen fibrils composed of a staggered array of tropocollagen molecules, which are connected by intermolecular cross-links. In this study, we report a three-dimensional coarse-grained model of collagen and analyze the influence of enzymatic cross-links on the mechanics of collagen fibrils. Two representatives immature and mature cross-links are implemented in the mesoscale model using a bottom-up approach. By varying the number, type and mechanical properties of cross-links in the fibrils and performing tensile test on the models, we systematically investigate the deformation mechanisms of cross-linked collagen fibrils. We find that cross-linked fibrils exhibit a three phase behavior, which agrees closer with experimental results than what was obtained using previous models. The fibril mechanical response is characterized by: (i) an initial elastic deformation corresponding to the collagen molecule uncoiling, (ii) a linear regime dominated by molecule sliding and (iii) the second stiffer elastic regime related to the stretching of the backbone of the tropocollagen molecules until the fibril ruptures. Our results suggest that both cross-link density and type dictate the stiffness of large deformation regime by increasing the number of interconnected molecules while cross-links mechanical properties determine the failure strain and strength of the fibril. These findings reveal that cross-links play an essential role in creating an interconnected fibrillar material of tunable toughness and strength. PMID:25153614

Perceived Gender Ratings for High and Low Scorers on the Autism-Spectrum Quotient Consistent with the Extreme Male Brain Account of Autism

PubMed Central

Simons, Jessica M.; Maybery, Murray T.; Leung, Doris; Ng, Honey L. H.; Whitehouse, Andrew J. O.

2015-01-01

The Extreme Male Brain (EMB) theory posits that autistic traits are linked to excessive exposure to testosterone in utero. While findings from a number of studies are consistent with this theory, other studies have produced contradictory results. For example, some findings suggest that rather than being linked to hypermasculinization for males, or defeminization for females, elevated levels of autistic traits are instead linked to more androgynous physical features. The current study provided further evidence relevant to the EMB and androgony positions by comparing groups of males selected for high or low scores on the Autism-spectrum Quotient (AQ) as to the rated masculinity of their faces and voices, and comparable groups of females as to the rated femininity of their faces and voices. The voices of High-AQ males were rated as more masculine than those of Low-AQ males, while the faces of High-AQ females were rated as less feminine than those of Low-AQ females. There was no effect of AQ group on femininity ratings for female voices or on masculinity ratings for male faces. The results thus provide partial support for a link between high levels of autistic-like traits and hypermasculinization for males and defeminization for females, consistent with the EMB theory. PMID:26186689

How people make friends in social networking sites—A microscopic perspective

NASA Astrophysics Data System (ADS)

Hu, Haibo; Wang, Xiaofan

2012-02-01

We study the detailed growth of a social networking site with full temporal information by examining the creation process of each friendship relation that can collectively lead to the macroscopic properties of the network. We first study the reciprocal behavior of users, and find that link requests are quickly responded to and that the distribution of reciprocation intervals decays in an exponential form. The degrees of inviters/accepters are slightly negatively correlative with reciprocation time. In addition, the temporal feature of the online community shows that the distributions of intervals of user behaviors, such as sending or accepting link requests, follow a power law with a universal exponent, and peaks emerge for intervals of an integral day. We finally study the preferential selection and linking phenomena of the social networking site and find that, for the former, a linear preference holds for preferential sending and reception, and for the latter, a linear preference also holds for preferential acceptance, creation, and attachment. Based on the linearly preferential linking, we put forward an analyzable network model which can reproduce the degree distribution of the network. The research framework presented in the paper could provide a potential insight into how the micro-motives of users lead to the global structure of online social networks.

Linking Essential Tremor to the Cerebellum: Neurochemical Evidence.

PubMed

Marin-Lahoz, Juan; Gironell, Alexandre

2016-06-01

The pathophysiology and the exact anatomy of essential tremor (ET) is not well known. One of the pillars that support the cerebellum as the main anatomical locus in ET is neurochemistry. This review examines the link between neurochemical abnormalities found in ET and cerebellum. The review is based on published data about neurochemical abnormalities described in ET both in human and in animal studies. We try to link those findings with cerebellum. γ-aminobutyric acid (GABA) is the main neurotransmitter involved in the pathophysiology of ET. There are several studies about GABA that clearly points to a main role of the cerebellum. There are few data about other neurochemical abnormalities in ET. These include studies with noradrenaline, glutamate, adenosine, proteins, and T-type calcium channels. One single study reveals high levels of noradrenaline in the cerebellar cortex. Another study about serotonin neurotransmitter results negative for cerebellum involvement. Finally, studies on T-type calcium channels yield positive results linking the rhythmicity of ET and cerebellum. Neurochemistry supports the cerebellum as the main anatomical locus in ET. The main neurotransmitter involved is GABA, and the GABA hypothesis remains the most robust pathophysiological theory of ET to date. However, this hypothesis does not rule out other mechanisms and may be seen as the main scaffold to support findings in other systems. We clearly need to perform more studies about neurochemistry in ET to better understand the relations among the diverse systems implied in ET. This is mandatory to develop more effective pharmacological therapies.

Composition of Junior Research Groups and Phd Completion Rate: Disciplinary Differences and Policy Implications

ERIC Educational Resources Information Center

Pull, Kerstin; Pferdmenges, Birgit; Backes-Gellner, Uschi

2016-01-01

This paper explores the link between the composition and the performance of junior research groups. The authors argue that the heterogeneity-performance link depends on the type of heterogeneity (cultural vs. study field) and on the disciplinary area. The authors test their hypotheses on a data set of 45 junior research groups and find a U-shaped…

Linking Teacher Socialization Research with a PETE Program: Insights from Beginning and Experienced Teachers

ERIC Educational Resources Information Center

MacPhail, Ann; Hartley, Therese

2016-01-01

The purpose of this study is to explore the extent to which beginning and experienced teachers differed in their perceptions of shaping school forces and their being shaped by school forces. The findings allow the authors to examine the link between teacher socialization research and practice in a physical education teacher education (PETE)…

Media and attention, cognition, and school achievement.

PubMed

Schmidt, Marie Evans; Vandewater, Elizabeth A

2008-01-01

Marie Evans Schmidt and Elizabeth Vandewater review research on links between various types of electronic media and the cognitive skills of school-aged children and adolescents. One central finding of studies to date, they say, is that the content delivered by electronic media is far more influential than the media themselves. Most studies, they point out, find a small negative link between the total hours a child spends viewing TV and that child's academic achievement. But when researchers take into account characteristics of the child, such as IQ or socioeconomic status, this link typically disappears. Content appears to be crucial. Viewing educational TV is linked positively with academic achievement; viewing entertainment TV is linked negatively with achievement. When it comes to particular cognitive skills, say the authors, researchers have found that electronic media, particularly video games, can enhance visual spatial skills, such as visual tracking, mental rotation, and target localization. Gaming may also improve problem-solving skills. Researchers have yet to understand fully the issue of transfer of learning from electronic media. Studies suggest that, under some circumstances, young people are able to transfer what they learn from electronic media to other applications, but analysts are uncertain how such transfer occurs. In response to growing public concern about possible links between electronic media use and attention problems in children and adolescents, say the authors, researchers have found evidence for small positive links between heavy electronic media use and mild attention problems among young people but have found only inconsistent evidence so far for a link between attention deficit hyperactivity disorder and media use. The authors point out that although video games, interactive websites, and multimedia software programs appear to offer a variety of possible benefits for learning, there is as yet little empirical evidence to suggest that such media are more effective than other forms of instruction.

How Do Children Spend Their Time? Children's Activities, School Achievement, and Well-Being. Research on Today's Issues, Issue No. 11.

ERIC Educational Resources Information Center

Population Reference Bureau, Inc., Washington, DC.

This briefing paper describes research findings on factors linked to children's school achievement and emotional adjustment. The findings are based on the Child Development Supplement of the Panel Study of Income Dynamics, a nationally representative, longitudinal study of children and families conducted at the University of Michigan and supported…

The Effects of a BDNF Val66Met Polymorphism on Posttraumatic Stress Disorder: A Meta-Analysis.

PubMed

Bountress, Kaitlin E; Bacanu, Silviu-Alin; Tomko, Rachel L; Korte, Kristina J; Hicks, Terrell; Sheerin, Christina; Lind, Mackenzie J; Marraccini, Marisa; Nugent, Nicole; Amstadter, Ananda B

2018-06-06

Given evidence that posttraumatic stress disorder (PTSD) is moderately heritable, a number of studies utilizing candidate gene approaches have attempted to examine the potential contributions of theoretically relevant genetic variation. Some of these studies have found sup port for a brain-derived neurotrophic factor (BDNF) variant, Val66Met, in the risk of developing PTSD, while others have failed to find this link. This study sought to reconcile these conflicting findings using a meta-analysis framework. Analyses were also used to determine whether there is significant heterogeneity in the link between this variant and PTSD. We conducted a systematic review of the literature on BDNF and PTSD from the PsycINFO and PubMed databases. A total of 11 studies were included in the analysis. Findings indicate a marginally significant effect of the BDNF Val66Met variant on PTSD (p < 0.1). However, of the 11 studies included, only 2 suggested an effect with a non-zero confidence interval, one of which showed a z score of 3.31. We did not find any evidence for heterogeneity. Findings from this meta-analytic investigation of the published literature provide little support for the Val66Met variant of BDNF as a predictor of PTSD. Future well-powered agnostic genome-wide association studies with more refined phenotyping are needed to clarify genetic influences on PTSD. © 2018 S. Karger AG, Basel.

Is the kinetoplast DNA a percolating network of linked rings at its critical point?

NASA Astrophysics Data System (ADS)

Michieletto, Davide; Marenduzzo, Davide; Orlandini, Enzo

2015-05-01

In this work we present a computational study of the kinetoplast genome, modelled as a large number of semiflexible unknotted loops, which are allowed to link with each other. As the DNA density increases, the systems shows a percolation transition between a gas of unlinked rings and a network of linked loops which spans the whole system. Close to the percolation transition, we find that the mean valency of the network, i.e. the average number of loops which are linked to any one loop, is around three, as found experimentally for the kinetoplast DNA (kDNA). Even more importantly, by simulating the digestion of the network by a restriction enzyme, we show that the distribution of oligomers, i.e. structures formed by a few loops which remain linked after digestion, quantitatively matches experimental data obtained from gel electrophoresis, provided that the density is, once again, close to the percolation transition. With respect to previous work, our analysis builds on a reduced number of assumptions, yet can still fully explain the experimental data. Our findings suggest that the kDNA can be viewed as a network of linked loops positioned very close to the percolation transition, and we discuss the possible biological implications of this remarkable fact.

Use of topical dorzolamide for patients with X-linked juvenile retinoschisis: case report.

PubMed

Bastos, André Luís Carvalho de Moura; Freitas, Bruno de Paula; Villas Boas, Oscar; Ramiro, Alexandre Campelo

2008-01-01

X-linked juvenile retinoschisis (XLRS) is a recessively inherited vitreoretinal degeneration characterized by macular pathology and splitting of the neuroretinal layers that is associated with alterations in the XLRS1 gene. There have been no therapeutic interventions known to be effective for patients with X-linked juvenile retinoschisis, but some studies are trying to determine the importance of dorzolamide for the treatment of foveal lesions in this disease. The authors, using optical coherence tomography, describe findings in a patient with X-linked juvenile retinoschisis, before and after a topical use of dorzolamide. Besides the improvement in his visual acuity, further studies are required to elucidate the real prevalence of nonresponse to dorzolamide and the frequency with which there may be a recurrence of foveal cystic changes during continued treatment.

Spreading of cooperative behaviour across interdependent groups

NASA Astrophysics Data System (ADS)

Jiang, Luo-Luo; Perc, Matjaž

2013-08-01

Recent empirical research has shown that links between groups reinforce individuals within groups to adopt cooperative behaviour. Moreover, links between networks may induce cascading failures, competitive percolation, or contribute to efficient transportation. Here we show that there in fact exists an intermediate fraction of links between groups that is optimal for the evolution of cooperation in the prisoner's dilemma game. We consider individual groups with regular, random, and scale-free topology, and study their different combinations to reveal that an intermediate interdependence optimally facilitates the spreading of cooperative behaviour between groups. Excessive between-group links simply unify the two groups and make them act as one, while too rare between-group links preclude a useful information flow between the two groups. Interestingly, we find that between-group links are more likely to connect two cooperators than in-group links, thus supporting the conclusion that they are of paramount importance.

Perceived discrimination predicts increased support for political rights and life satisfaction mediated by ethnic identity: A longitudinal analysis.

PubMed

Stronge, Samantha; Sengupta, Nikhil K; Barlow, Fiona Kate; Osborne, Danny; Houkamau, Carla A; Sibley, Chris G

2016-07-01

The aim of the current research is to test predictions derived from the rejection-identification model and research on collective action using cross-sectional (Study 1) and longitudinal (Study 2) methods. Specifically, an integration of these 2 literatures suggests that recognition of discrimination can have simultaneous positive relationships with well-being and engagement in collective action via the formation of a strong ingroup identity. We test these predictions in 2 studies using data from a large national probability sample of Māori (the indigenous peoples of New Zealand), collected as part of the New Zealand Attitudes and Values Study (Ns for Study 1 and 2 were 1,981 and 1,373, respectively). Consistent with the extant research, Study 1 showed that perceived discrimination was directly linked with decreased life satisfaction, but indirectly linked with increased life satisfaction through higher levels of ethnic identification. Perceived discrimination was also directly linked with increased support for Māori rights and indirectly linked with increased support for Māori rights through higher levels of ethnic identification. Study 2 replicated these findings using longitudinal data and identified multiple bidirectional paths between perceived discrimination, ethnic identity, well-being, and support for collective action. These findings replicate and extend the rejection-identification model in a novel cultural context by demonstrating via cross-sectional (Study 1) and longitudinal (Study 2) analyses that the recognition of discrimination can both motivate support for political rights and increase well-being by strengthening ingroup identity. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Findings from an Independent Evaluation of the AMNH's Online Seminars on Science Course: "The Link between Dinosaurs and Birds"

ERIC Educational Resources Information Center

Inverness Research, 2008

2008-01-01

Inverness Research studied the American Museum of Natural History's (AMNH) Seminars on Science program for eight years, from its inception in 1998 to 2006. This paper presents teacher survey ratings for "The Link between Dinosaurs and Birds", along with profiles of three teachers who took the course. Course takers report on the annual…

Influence of cross-link structure, density and mechanical properties in the mesoscale deformation mechanisms of collagen fibrils.

PubMed

Depalle, Baptiste; Qin, Zhao; Shefelbine, Sandra J; Buehler, Markus J

2015-12-01

Collagen is a ubiquitous protein with remarkable mechanical properties. It is highly elastic, shows large fracture strength and enables substantial energy dissipation during deformation. Most of the connective tissue in humans consists of collagen fibrils composed of a staggered array of tropocollagen molecules, which are connected by intermolecular cross-links. In this study, we report a three-dimensional coarse-grained model of collagen and analyze the influence of enzymatic cross-links on the mechanics of collagen fibrils. Two representatives immature and mature cross-links are implemented in the mesoscale model using a bottom-up approach. By varying the number, type and mechanical properties of cross-links in the fibrils and performing tensile test on the models, we systematically investigate the deformation mechanisms of cross-linked collagen fibrils. We find that cross-linked fibrils exhibit a three phase behavior, which agrees closer with experimental results than what was obtained using previous models. The fibril mechanical response is characterized by: (i) an initial elastic deformation corresponding to the collagen molecule uncoiling, (ii) a linear regime dominated by molecule sliding and (iii) the second stiffer elastic regime related to the stretching of the backbone of the tropocollagen molecules until the fibril ruptures. Our results suggest that both cross-link density and type dictate the stiffness of large deformation regime by increasing the number of interconnected molecules while cross-links mechanical properties determine the failure strain and strength of the fibril. These findings reveal that cross-links play an essential role in creating an interconnected fibrillar material of tunable toughness and strength. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

Introduction of a child and adolescent mental health link worker: education and health staff focus group findings.

PubMed

Hunter, A; Playle, J; Sanchez, P; Cahill, J; McGowan, L

2008-10-01

Policy guidance suggests that outcomes for adolescents with mental health problems can be improved by secondary education services (SES) and child and adolescent mental health services (CAMHS) working more closely. This study reports on staff experiences of the introduction of a mental health link worker (MHLW). The findings of two focus groups are presented, conducted with staff from CAMHS and SES. These focus groups formed part of the overall wider evaluation of the MHLW role. The groups explored staff perceptions and experiences following the introduction of the MHLW, and elicited their views on the effectiveness of this innovative role. Qualitative methods were employed, and analysis was conducted using the principles of grounded theory and the constant comparative method. The findings revealed that the MHLW was well received by both groups, despite the identification of potential barriers. A number of key themes emerged, which included the ability of the link worker to improve communication and to encourage mutual understanding between services. The issues raised by these themes are discussed and recommendations are made for future practice and research.

We Knew It All Along! Using Cognitive Science to Explain How Andragogy Works

ERIC Educational Resources Information Center

Hagen, Marcia; Park, Sunyoung

2016-01-01

Purpose: This paper aims to link recent findings in cognitive neuroscience to better understand how andragogically informed instructional practices impact cognition and learning. Design/Methodology/Approach: The research questions guiding the study is in what ways can the recent findings in cognitive neuroscience help to inform adult education…

Linking Recent Research in Cognitive Science and Problem Solving to Instructional Practice: New Possibilities.

ERIC Educational Resources Information Center

Lippert, Renate

The application of recent advances in the understanding of problem solving to the classroom is reviewed. Current research findings are described, and the instructional validity of these findings is illustrated by a research study of an instructional strategy called novice knowledge engineering. How various instructional strategies serve as…

The dual frontier: Patented inventions and prior scientific advance.

PubMed

Ahmadpoor, Mohammad; Jones, Benjamin F

2017-08-11

The extent to which scientific advances support marketplace inventions is largely unknown. We study 4.8 million U.S. patents and 32 million research articles to determine the minimum citation distance between patented inventions and prior scientific advances. We find that most cited research articles (80%) link forward to a future patent. Similarly, most patents (61%) link backward to a prior research article. Linked papers and patents typically stand 2 to 4 degrees distant from the other domain. Yet, advances directly along the patent-paper boundary are notably more impactful within their own domains. The distance metric further provides a typology of the fields, institutions, and individuals involved in science-to-technology linkages. Overall, the findings are consistent with theories that emphasize substantial and fruitful connections between patenting and prior scientific inquiry. Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Somatosensory Representations Link the Perception of Emotional Expressions and Sensory Experience.

PubMed

Kragel, Philip A; LaBar, Kevin S

2016-01-01

Studies of human emotion perception have linked a distributed set of brain regions to the recognition of emotion in facial, vocal, and body expressions. In particular, lesions to somatosensory cortex in the right hemisphere have been shown to impair recognition of facial and vocal expressions of emotion. Although these findings suggest that somatosensory cortex represents body states associated with distinct emotions, such as a furrowed brow or gaping jaw, functional evidence directly linking somatosensory activity and subjective experience during emotion perception is critically lacking. Using functional magnetic resonance imaging and multivariate decoding techniques, we show that perceiving vocal and facial expressions of emotion yields hemodynamic activity in right somatosensory cortex that discriminates among emotion categories, exhibits somatotopic organization, and tracks self-reported sensory experience. The findings both support embodied accounts of emotion and provide mechanistic insight into how emotional expressions are capable of biasing subjective experience in those who perceive them.

Somatosensory Representations Link the Perception of Emotional Expressions and Sensory Experience123

PubMed Central

2016-01-01

Abstract Studies of human emotion perception have linked a distributed set of brain regions to the recognition of emotion in facial, vocal, and body expressions. In particular, lesions to somatosensory cortex in the right hemisphere have been shown to impair recognition of facial and vocal expressions of emotion. Although these findings suggest that somatosensory cortex represents body states associated with distinct emotions, such as a furrowed brow or gaping jaw, functional evidence directly linking somatosensory activity and subjective experience during emotion perception is critically lacking. Using functional magnetic resonance imaging and multivariate decoding techniques, we show that perceiving vocal and facial expressions of emotion yields hemodynamic activity in right somatosensory cortex that discriminates among emotion categories, exhibits somatotopic organization, and tracks self-reported sensory experience. The findings both support embodied accounts of emotion and provide mechanistic insight into how emotional expressions are capable of biasing subjective experience in those who perceive them. PMID:27280154

Cross-linking of type I collagen with microbial transglutaminase: identification of cross-linking sites.

PubMed

Stachel, Ines; Schwarzenbolz, Uwe; Henle, Thomas; Meyer, Michael

2010-03-08

Collagen is a popular biomaterial. To deal with its lack of thermal stability and its weak resistance to proteolytic degradation, collagen-based materials are stabilized via different cross-linking procedures. Regarding the potential toxicity of residual cross-linking agents, enzyme-mediated cross-linking would provide an alternative and nontoxic method for collagen stabilization. The results of this study show that type I collagen is a substrate for mTG. However, epsilon-(gamma-glutamyl)lysine cross-links are only incorporated at elevated temperatures when the protein is partially or completely denatured. A maximum number of 5.4 cross-links per collagen monomer were found for heat-denatured collagen. Labeling with the primary amine monodansylcadaverine revealed that at least half of the cross-links are located within the triple helical region of the collagen molecule. Because the triple helix is highly ordered in its native state, this finding might explain why the glutamine residues are inaccessible for mTG under nondenaturing conditions.

Altered morphology of the nucleus accumbens in persistent developmental stuttering.

PubMed

Neef, Nicole E; Bütfering, Christoph; Auer, Tibor; Metzger, F Luise; Euler, Harald A; Frahm, Jens; Paulus, Walter; Sommer, Martin

2018-03-01

Neuroimaging studies in persistent developmental stuttering repeatedly report altered basal ganglia functions. Together with thalamus and cerebellum, these structures mediate sensorimotor functions and thus represent a plausible link between stuttering and neuroanatomy. However, stuttering is a complex, multifactorial disorder. Besides sensorimotor functions, emotional and social-motivational factors constitute major aspects of the disorder. Here, we investigated cortical and subcortical gray matter regions to study whether persistent developmental stuttering is also linked to alterations of limbic structures. The study included 33 right-handed participants who stutter and 34 right-handed control participants matched for sex, age, and education. Structural images were acquired using magnetic resonance imaging to estimate volumetric characteristics of the nucleus accumbens, hippocampus, amygdala, pallidum, putamen, caudate nucleus, and thalamus. Volumetric comparisons and vertex-based shape comparisons revealed structural differences. The right nucleus accumbens was larger in participants who stutter compared to controls. Recent theories of basal ganglia functions suggest that the nucleus accumbens is a motivation-to-movement interface. A speaker intends to reach communicative goals, but stuttering can derail these efforts. It is therefore highly plausible to find alterations in the motivation-to-movement interface in stuttering. While behavioral studies of stuttering sought to find links between the limbic and sensorimotor system, we provide the first neuroimaging evidence of alterations in the limbic system. Thus, our findings might initialize a unified neurobiological framework of persistent developmental stuttering that integrates sensorimotor and social-motivational neuroanatomical circuitries. Copyright © 2017 Elsevier Inc. All rights reserved.

Collagen type IX from human cartilage: a structural profile of intermolecular cross-linking sites.

PubMed Central

Diab, M; Wu, J J; Eyre, D R

1996-01-01

Type IX collagen, a quantitatively minor collagenous component of cartilage, is known to be associated with and covalently cross-linked to type II collagen fibrils in chick and bovine cartilage. Type IX collagen molecules have also been shown to form covalent cross-links with each other in bovine cartilage. In the present study we demonstrate by structural analysis and location of cross-linking sites that, in human cartilage, type IX collagen is covalently cross-linked to type II collagen and to other molecules of type IX collagen. We also present evidence that, if the proteoglycan form of type IX collagen is present in human cartilage, it can only be a minor component of the matrix, similar to findings with bovine cartilage. PMID:8660302

A Systematic Review of the Processes Underlying the Main and the Buffering Effect of Social Support on the Experience of Pain.

PubMed

Che, Xianwei; Cash, Robin; Ng, Sin Ki; Fitzgerald, Paul; Fitzgibbon, Bernadette M

2018-04-24

This review aimed to explore the processes that underlie the main and the buffering effect of social support on decreased pain experience. The systematic review was conducted according to the PRISMA guidelines. Online databases of PubMed and PsycINFO were searched for peer-reviewed articles using keywords (("social support", OR "interpersonal", OR "social presence", OR "spouse", OR "couple", OR "marriage") AND "pain"). Articles were included if they examined the cognitive or behavioural processes linking social support to any aspects of reduced pain experience. The database search identified 38 studies, of which 33 were cognitive-behavioural studies and 5 were neurobiological. Cognitive-behavioural studies generated a total of 57 findings of the analgesic influence of social support. This effect was further categorized as social support decreasing the adverse influence of pain-related stress (28/44 findings), reappraising pain-related stress (7/9 findings), and facilitating coping attempts (2/4 findings). Of the 5 neurobiological studies, the influence of social support on pain reduction was associated with reduced neural and physiological stress systems in response to painful stimuli. This review presents evidence that the stress-buffering effect is more often able to account for the relationship between social support and pain experience. Moreover, findings suggest the critical significance of stress appraisal and attenuated stress systems in linking social support to aspects of reduced pain experience. Findings implicate the role of integrating perceived support and intimacy in support-oriented interventional trials for chronic pain.

Find a Periodontist

MedlinePlus

... American Academy of Periodontology Names New Executive Director Marijuana Use Linked to Increased Gum Disease Risk Gum ... ADA Liaison AAP Grants Periodontal Societies AAP Member Benefits AAP/Colgate Study Club Program Perio Store Education & ...

Evaluating the Link between Self-Esteem and Temperament in Mexican Origin Early Adolescents

PubMed Central

Robins, Richard W.; Donnellan, M. Brent; Widaman, Keith F.; Conger, Rand D.

2009-01-01

The present study examined the relation between self-esteem and temperament in a sample of 646 Mexican-American early adolescents (mean age=10.4). Self-esteem was assessed using child reports on the Self-Description Questionnaire II—Short (SDQII-S; Marsh et al., 2005) and temperament was assessed using child and mother reports on the revised Early Adolescent Temperament Questionnaire (Ellis & Rothbart, 2001). Findings show that: (a) early adolescents with high self-esteem show higher levels of Effortful Control but, contrary to findings in adult samples, do not differ from low self-esteem adolescents in Negative Affectivity; (b) low self-esteem is associated with Depression; and (c) low self-esteem is associated with Aggression. These findings replicated for boys and girls, two measures of self-esteem, and child and mother reports of temperament. The present study contributes to an emerging understanding of the link between self-esteem and temperament, and provides much needed data on the nature of self-esteem in ethnic minority populations. PMID:19740537

Two cases of X-linked juvenile retinoschisis with different optical coherence tomography findings and RS1 gene mutations.

PubMed

Chan, Wai Man; Choy, Kwong Wai; Wang, Jianghua; Lam, Dennis S C; Yip, Wilson W K; Fu, Weiling; Pang, Chi Pui

2004-08-01

The optical coherence tomography (OCT) findings, clinical features, and mutations in the RS1 gene of two unrelated patients with X-linked retinoschisis (XLRS) are reported herein. Two Chinese patients with early onset XLRS were given a comprehensive ophthalmologic examination and OCT investigation. The RS1 gene was screened for sequence alterations in all exons and splice regions. The two patients presented with different phenotypic features and OCT findings. One patient with more severe clinical presentation had a RS1 exon 1 deletion and a P193S mutation was found in the other patient with mild macular involvement. OCT demonstrates the markedly different features of XLRS patients with different RS1 mutations. This study strengthens the role of OCT in the diagnosis and monitoring of XLRS.

Differences in Psychoactive Substance Abuse Between Youths Residing in and Outside Conflict Zones as a Function of Level of Religiosity and Political Commitment.

PubMed

Ne'eman-Haviv, Vered; Wilchek-Aviad, Yael

2017-08-24

The aim of the present study was to examine the effect of the unique characteristics of residing in security and political conflict zones on the willingness to use and on the actual abuse of psychoactive substances. The study focuses on the differences between youths residing in and outside conflict zones in Israel. The present study examines the link between the adolescents' level of psychoactive substance abuse and town size as well as the youths' level of ideological commitment and religiosity. 1032 adolescents aged 14-18 participated in the study. 595 (57%) lived in the nonconflict zones and 437 (43%) in conflict zones. The findings reveal that the level of psychoactive substance abuse among youths residing in conflict zones is significantly lower than that found among youths living outside conflict zones. Moreover, although town size and level of religiosity are linked to psychoactive substance abuse, no such link was found with the level of ideological commitment or place of residence (within or outside conflict zones). The study findings underscore the important effect of social supervision and perceived norms in the adolescents' environment with regard to their willingness to use psychoactive substances and to their actual abuse of such substances.

Revisiting the Link between Job Satisfaction and Life Satisfaction: The Role of Basic Psychological Needs

PubMed Central

Unanue, Wenceslao; Gómez, Marcos E.; Cortez, Diego; Oyanedel, Juan C.; Mendiburo-Seguel, Andrés

2017-01-01

The link between job satisfaction and life satisfaction has been extensively explored in the relevant literature. However, the great majority of past research has been carried out using cross-sectional analyses, and almost exclusively in the Western world. Moreover, the underlying psychological mechanisms explaining the link are not yet completely understood. Thus, we report the first research to date which uses both cross-sectional and longitudinal data among workers in Chile—a fast-developing Latin American economy—and which aims to tackle previous limitations. Three studies consistently support a positive link between the constructs. Study 1 (N = 636) found that higher job satisfaction predicted higher life satisfaction both contemporaneously and longitudinally, and vice versa, above and beyond several key control variables. Study 2 (N = 725) and Study 3 (N = 703) replicated Study 1 results, but tested for the first time the role of satisfaction of basic psychological needs (as stated by self-determination theory) in the job–life satisfaction link. This is the most novel contribution of our paper. Key implications not only for individual quality of life, but also for companies' human resource practices emerge from our findings. PMID:28536541

Sexual education, gender ideology, and youth sexual empowerment.

PubMed

Grose, Rose Grace; Grabe, Shelly; Kohfeldt, Danielle

2014-01-01

Sexual education plays an essential role in preventing unplanned pregnancy and the transmission of sexually transmitted infections (STIs). School-based sexual education programs, in particular, may be well positioned to address social factors that are empirically linked to negative sexual health outcomes, such as traditional social norms surrounding gender and sexuality. However, youth are seldom granted access to sexual education programs that explicitly address these issues. This study presents findings from a pretest-posttest survey of a sexual education program that did. It was designed for eighth graders (N=95) in the context of a school-community collaboration. The study assessed the links between several components of sexual empowerment, including gender ideology, sexual knowledge, and contraceptive beliefs. Findings link participation in the sexual education program to more progressive attitudes toward girls and women, less agreement with hegemonic masculinity ideology, and increases in sexual health and resource knowledge. Structural equation models suggest that traditional attitudes toward women were significantly related to hegemonic masculinity ideology among both boys and girls, which was in turn negatively related to safer contraceptive beliefs.

Forging a Link between Research and Pedagogy: A Holistic Framework for Evaluating Business English Materials

ERIC Educational Resources Information Center

Chan, Clarice S. C.

2009-01-01

In the last two decades, a great deal of applied linguistics research has been conducted in different areas of business English. However, despite many highly relevant research findings, the interface between research and pedagogy remains weak. One reason behind this lack of interface is that research findings from different studies are rarely…

The Health Rationale for Family Planning: Timing of Births and Child Survival.

ERIC Educational Resources Information Center

United Nations, New York, NY. Population Div.

Among the most influential findings from the World Fertility Survey (WFS) were those linking fertility patterns to child survival, in particular the findings concerning the high infant and child mortality for children born after a short birth interval. This study examined the relations between fertility and child survival based on more recent data…

Preliminary findings of altered functional connectivity of the default mode network linked to functional outcomes one year after pediatric traumatic brain injury.

PubMed

Stephens, Jaclyn A; Salorio, Cynthia F; Barber, Anita D; Risen, Sarah R; Mostofsky, Stewart H; Suskauer, Stacy J

2017-07-10

This study examined functional connectivity of the default mode network (DMN) and examined brain-behavior relationships in a pilot cohort of children with chronic mild to moderate traumatic brain injury (TBI). Compared to uninjured peers, children with TBI demonstrated less anti-correlated functional connectivity between DMN and right Brodmann Area 40 (BA 40). In children with TBI, more anomalous less anti-correlated) connectivity between DMN and right BA 40 was linked to poorer performance on response inhibition tasks. Collectively, these preliminary findings suggest that functional connectivity between DMN and BA 40 may relate to longterm functional outcomes in chronic pediatric TBI.

Cascading failures in interdependent networks with finite functional components

NASA Astrophysics Data System (ADS)

Di Muro, M. A.; Buldyrev, S. V.; Stanley, H. E.; Braunstein, L. A.

2016-10-01

We present a cascading failure model of two interdependent networks in which functional nodes belong to components of size greater than or equal to s . We find theoretically and via simulation that in complex networks with random dependency links the transition is first order for s ≥3 and continuous for s =2 . We also study interdependent lattices with a distance constraint r in the dependency links and find that increasing r moves the system from a regime without a phase transition to one with a second-order transition. As r continues to increase, the system collapses in a first-order transition. Each regime is associated with a different structure of domain formation of functional nodes.

Biodiversity and disease: a synthesis of ecological perspectives on Lyme disease transmission.

USGS Publications Warehouse

Wood, Chelsea L.; Lafferty, Kevin D.

2013-01-01

Recent reviews have argued that disease control is among the ecosystem services yielded by biodiversity. Lyme disease (LD) is commonly cited as the best example of the ‘diluting’ effect of biodiversity on disease transmission, but many studies document the opposite relationship, showing that human LD risk can increase with forestation. Here, we unify these divergent perspectives and find strong evidence for a positive link between biodiversity and LD at broad spatial scales (urban to suburban to rural) and equivocal evidence for a negative link between biodiversity and LD at varying levels of biodiversity within forests. This finding suggests that, across zoonotic disease agents, the biodiversity–disease relationship is scale dependent and complex.

Officer Career Development: Longitudinal Sample--Fiscal Year 1982

DTIC Science & Technology

1991-10-01

Those that wish to access the database to conduct additional analyses, link it to or combine it with other databases, enlarge the database for the...link it to or combine it with other databases, enlarge the database for the conduct of trend analyses, etc., will find this data dictionary an...analyses, link it to or combine it with other databases, enlarge the database for the conduct of trend analyses, etc., will find this data dictionary

Linking Air Pollution and Heart Disease

EPA Pesticide Factsheets

Science Matters article about a study finding that exposure to particulate matter and nitrogen oxides can prematurely age blood vessels and contribute to a more rapid buildup of calcium in the coronary artery.

How the contagion at links influences epidemic spreading

NASA Astrophysics Data System (ADS)

Ruan, Zhongyuan; Tang, Ming; Liu, Zonghua

2013-04-01

The reaction-diffusion (RD) model of epidemic spreading generally assume that contagion occurs only at the nodes of network, i.e., the links are used only for migration/diffusion of agents. However, in reality, we observe that contagion occurs also among the travelers staying in the same car, train or plane etc., which consist of the links of network. To reflect the contagious effect of links, we here present a traveling-contagion model where contagion occurs not only at nodes but also at links. Considering that the population density in transportation is generally much larger than that in districts, we introduce different infection rates for the nodes and links, respectively, whose two extreme cases correspond to the type-I and type-II reactions in the RD model [V. Colizza, R. Pastor-Satorras, A. Vespignani, Nat. Phys. 3, 276 (2007)]. Through studying three typical diffusion processes, we reveal both numerically and theoretically that the contagion at links can accelerate significantly the epidemic spreading. This finding is helpful in designing the controlling strategies of epidemic spreading.

Multimodal fusion of brain imaging data: A key to finding the missing link(s) in complex mental illness

PubMed Central

Calhoun, Vince D; Sui, Jing

2016-01-01

It is becoming increasingly clear that combining multi-modal brain imaging data is able to provide more information for individual subjects by exploiting the rich multimodal information that exists. However, the number of studies that do true multimodal fusion (i.e. capitalizing on joint information among modalities) is still remarkably small given the known benefits. In part, this is because multi-modal studies require broader expertise in collecting, analyzing, and interpreting the results than do unimodal studies. In this paper, we start by introducing the basic reasons why multimodal data fusion is important and what it can do, and importantly how it can help us avoid wrong conclusions and help compensate for imperfect brain imaging studies. We also discuss the challenges that need to be confronted for such approaches to be more widely applied by the community. We then provide a review of the diverse studies that have used multimodal data fusion (primarily focused on psychosis) as well as provide an introduction to some of the existing analytic approaches. Finally, we discuss some up-and-coming approaches to multi-modal fusion including deep learning and multimodal classification which show considerable promise. Our conclusion is that multimodal data fusion is rapidly growing, but it is still underutilized. The complexity of the human brain coupled with the incomplete measurement provided by existing imaging technology makes multimodal fusion essential in order to mitigate against misdirection and hopefully provide a key to finding the missing link(s) in complex mental illness. PMID:27347565

Multimodal fusion of brain imaging data: A key to finding the missing link(s) in complex mental illness.

PubMed

Calhoun, Vince D; Sui, Jing

2016-05-01

It is becoming increasingly clear that combining multi-modal brain imaging data is able to provide more information for individual subjects by exploiting the rich multimodal information that exists. However, the number of studies that do true multimodal fusion (i.e. capitalizing on joint information among modalities) is still remarkably small given the known benefits. In part, this is because multi-modal studies require broader expertise in collecting, analyzing, and interpreting the results than do unimodal studies. In this paper, we start by introducing the basic reasons why multimodal data fusion is important and what it can do, and importantly how it can help us avoid wrong conclusions and help compensate for imperfect brain imaging studies. We also discuss the challenges that need to be confronted for such approaches to be more widely applied by the community. We then provide a review of the diverse studies that have used multimodal data fusion (primarily focused on psychosis) as well as provide an introduction to some of the existing analytic approaches. Finally, we discuss some up-and-coming approaches to multi-modal fusion including deep learning and multimodal classification which show considerable promise. Our conclusion is that multimodal data fusion is rapidly growing, but it is still underutilized. The complexity of the human brain coupled with the incomplete measurement provided by existing imaging technology makes multimodal fusion essential in order to mitigate against misdirection and hopefully provide a key to finding the missing link(s) in complex mental illness.

Cross-Linking and Mass Spectrometry Methodologies to Facilitate Structural Biology: Finding a Path through the Maze

DOE Office of Scientific and Technical Information (OSTI.GOV)

Merkley, Eric D.; Cort, John R.; Adkins, Joshua N.

2013-09-01

Multiprotein complexes, rather than individual proteins, make up a large part of the biological macromolecular machinery of a cell. Understanding the structure and organization of these complexes is critical to understanding cellular function. Chemical cross-linking coupled with mass spectrometry is emerging as a complementary technique to traditional structural biology methods and can provide low-resolution structural information for a multitude of purposes, such as distance constraints in computational modeling of protein complexes. In this review, we discuss the experimental considerations for successful application of chemical cross-linking-mass spectrometry in biological studies and highlight three examples of such studies from the recent literature.more » These examples (as well as many others) illustrate the utility of a chemical cross-linking-mass spectrometry approach in facilitating structural analysis of large and challenging complexes.« less

Facial Width-to-Height Ratio Does Not Predict Self-Reported Behavioral Tendencies.

PubMed

Kosinski, Michal

2017-11-01

A growing number of studies have linked facial width-to-height ratio (fWHR) with various antisocial or violent behavioral tendencies. However, those studies have predominantly been laboratory based and low powered. This work reexamined the links between fWHR and behavioral tendencies in a large sample of 137,163 participants. Behavioral tendencies were measured using 55 well-established psychometric scales, including self-report scales measuring intelligence, domains and facets of the five-factor model of personality, impulsiveness, sense of fairness, sensational interests, self-monitoring, impression management, and satisfaction with life. The findings revealed that fWHR is not substantially linked with any of these self-reported measures of behavioral tendencies, calling into question whether the links between fWHR and behavior generalize beyond the small samples and specific experimental settings that have been used in past fWHR research.

2q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia

PubMed Central

Karayiorgou, Maria; Simon, Tony J.; Gogos, Joseph A.

2010-01-01

Recent studies are beginning to paint a clear and consistent picture of the impairments in psychological and cognitive competencies that are associated with microdeletions in chromosome 22q11.2. These studies have highlighted a strong link between this genetic lesion and schizophrenia. Parallel studies in humans and animal models are starting to uncover the complex genetic and neural substrates altered by the microdeletion. In addition to offering a deeper understanding of the effects of this genetic lesion, these findings may guide analysis of other copy-number variants associated with cognitive dysfunction and psychiatric disorders. PMID:20485365

Management Commitment to Safety, Teamwork, and Hospital Worker Injuries.

PubMed

McGonagle, Alyssa K; Essenmacher, Lynnette; Hamblin, Lydia; Luborsky, Mark; Upfal, Mark; Arnetz, Judith

2016-01-01

Although many studies link teamwork in health care settings to patient safety, evidence linking teamwork to hospital worker safety is lacking. This study addresses this gap by providing evidence linking teamwork perceptions in hospital workers to worker injuries, and further, finds a linkage between manager commitment to safety and teamwork. Organizational records of worker injuries and survey responses regarding management commitment to safety and teamwork from 446 hospital workers within 42 work units in a multi-site hospital system were examined. Results underscored the particular importance of teamwork on worker injuries as well as the importance of management commitment to safety as relating to teamwork. To improve worker safety, organizational leaders and unit managers should work to maintain environments wherein teamwork can thrive.

Management Commitment to Safety, Teamwork, and Hospital Worker Injuries

PubMed Central

McGonagle, Alyssa K.; Essenmacher, Lynnette; Hamblin, Lydia; Luborsky, Mark; Upfal, Mark; Arnetz, Judith

2016-01-01

Although many studies link teamwork in health care settings to patient safety, evidence linking teamwork to hospital worker safety is lacking. This study addresses this gap by providing evidence linking teamwork perceptions in hospital workers to worker injuries, and further, finds a linkage between manager commitment to safety and teamwork. Organizational records of worker injuries and survey responses regarding management commitment to safety and teamwork from 446 hospital workers within 42 work units in a multi-site hospital system were examined. Results underscored the particular importance of teamwork on worker injuries as well as the importance of management commitment to safety as relating to teamwork. To improve worker safety, organizational leaders and unit managers should work to maintain environments wherein teamwork can thrive. PMID:27867448

Functions of reminiscence and the psychological well-being of young-old and older adults over time.

PubMed

O'Rourke, Norm; Cappeliez, Philippe; Claxton, Amy

2011-03-01

Existing cross-sectional research demonstrates an association between reminiscence functions and well-being in later life. The results of this study replicate and extend previous findings in separate participant samples above and below 70 years of age. Findings suggest a link between reminiscence functions and psychological well-being, and indirectly between reminiscence and well-being 16 months thereafter. Invariance analyses reveal few differences in association between reminiscence and well-being when young-old (n = 196) and older adults (n = 215) are compared. These findings suggest a direct positive association between self-positive reminiscence functions (identity, death preparation, and problem-solving) and a direct negative association between self-negative functions (boredom reduction, bitterness revival, and intimacy maintenance) and psychological well-being (life satisfaction, depressive, and anxiety symptoms). In contrast, prosocial reminiscence functions (conversation, teach/inform others) appear to have an indirect association with well-being (i.e., via self-positive and self-negative functions). These findings are discussed relative to evolving theory and research linking cognition and health.

Chemical crosslinking and mass spectrometry studies of the structure and dynamics of membrane proteins and receptors.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Haskins, William E.; Leavell, Michael D.; Lane, Pamela

2005-03-01

Membrane proteins make up a diverse and important subset of proteins for which structural information is limited. In this study, chemical cross-linking and mass spectrometry were used to explore the structure of the G-protein-coupled photoreceptor bovine rhodopsin in the dark-state conformation. All experiments were performed in rod outer segment membranes using amino acid 'handles' in the native protein sequence and thus minimizing perturbations to the native protein structure. Cysteine and lysine residues were covalently cross-linked using commercially available reagents with a range of linker arm lengths. Following chemical digestion of cross-linked protein, cross-linked peptides were identified by accurate mass measurementmore » using liquid chromatography-fourier transform mass spectrometry and an automated data analysis pipeline. Assignments were confirmed and, if necessary, resolved, by tandem MS. The relative reactivity of lysine residues participating in cross-links was evaluated by labeling with NHS-esters. A distinct pattern of cross-link formation within the C-terminal domain, and between loop I and the C-terminal domain, emerged. Theoretical distances based on cross-linking were compared to inter-atomic distances determined from the energy-minimized X-ray crystal structure and Monte Carlo conformational search procedures. In general, the observed cross-links can be explained by re-positioning participating side-chains without significantly altering backbone structure. One exception, between C3 16 and K325, requires backbone motion to bring the reactive atoms into sufficient proximity for cross-linking. Evidence from other studies suggests that residues around K325 for a region of high backbone mobility. These findings show that cross-linking studies can provide insight into the structural dynamics of membrane proteins in their native environment.« less

Collection and analysis of 2013-2014 travel time data.

DOT National Transportation Integrated Search

2017-07-04

This report documents the findings of Planning Study 27, Collection and Analysis of 2013-2014 Travel Time Data, which is a continuation of Planning Study 24, Analysis of Historical Travel Time Data. The main scope is to analyze newly acquired link-re...

Supporting Communication and Coordination in Collaborative Sensemaking.

PubMed

Mahyar, Narges; Tory, Melanie

2014-12-01

When people work together to analyze a data set, they need to organize their findings, hypotheses, and evidence, share that information with their collaborators, and coordinate activities amongst team members. Sharing externalizations (recorded information such as notes) could increase awareness and assist with team communication and coordination. However, we currently know little about how to provide tool support for this sort of sharing. We explore how linked common work (LCW) can be employed within a `collaborative thinking space', to facilitate synchronous collaborative sensemaking activities in Visual Analytics (VA). Collaborative thinking spaces provide an environment for analysts to record, organize, share and connect externalizations. Our tool, CLIP, extends earlier thinking spaces by integrating LCW features that reveal relationships between collaborators' findings. We conducted a user study comparing CLIP to a baseline version without LCW. Results demonstrated that LCW significantly improved analytic outcomes at a collaborative intelligence task. Groups using CLIP were also able to more effectively coordinate their work, and held more discussion of their findings and hypotheses. LCW enabled them to maintain awareness of each other's activities and findings and link those findings to their own work, preventing disruptive oral awareness notifications.

Social cues and ideology.

PubMed

Mansell, Jordan

2018-01-01

Research shows that individuals with liberal and conservative ideological orientations display different value positions concerning the acceptance of social change and inequality. Research also links the expression of different values to a number of biological factors, including heredity. In light of these biological influences, I investigate whether differences in social values associated with liberal and conservative ideologies reflect alternative strategies to maximize returns from social interactions. Using an American sample of Democrats and Republicans, I test whether information about shared and unshared social values in the form of implicit social attitudes have a disproportionate effect on the willingness of Democrats and Republicans to trust an anonymous social partner. I find evidence that knowledge of shared values significantly increases levels of trust among Democrats but not Republicans. I further find that knowledge of unshared values significantly decreases trust among Republicans but not Democrats. These findings are consistent with studies indicating that differences in ideological orientation are linked to differences in cognition and decision-making.

Discovering disease-disease associations by fusing systems-level molecular data

PubMed Central

Žitnik, Marinka; Janjić, Vuk; Larminie, Chris; Zupan, Blaž; Pržulj, Nataša

2013-01-01

The advent of genome-scale genetic and genomic studies allows new insight into disease classification. Recently, a shift was made from linking diseases simply based on their shared genes towards systems-level integration of molecular data. Here, we aim to find relationships between diseases based on evidence from fusing all available molecular interaction and ontology data. We propose a multi-level hierarchy of disease classes that significantly overlaps with existing disease classification. In it, we find 14 disease-disease associations currently not present in Disease Ontology and provide evidence for their relationships through comorbidity data and literature curation. Interestingly, even though the number of known human genetic interactions is currently very small, we find they are the most important predictor of a link between diseases. Finally, we show that omission of any one of the included data sources reduces prediction quality, further highlighting the importance in the paradigm shift towards systems-level data fusion. PMID:24232732

Discovering disease-disease associations by fusing systems-level molecular data.

PubMed

Žitnik, Marinka; Janjić, Vuk; Larminie, Chris; Zupan, Blaž; Pržulj, Nataša

2013-11-15

The advent of genome-scale genetic and genomic studies allows new insight into disease classification. Recently, a shift was made from linking diseases simply based on their shared genes towards systems-level integration of molecular data. Here, we aim to find relationships between diseases based on evidence from fusing all available molecular interaction and ontology data. We propose a multi-level hierarchy of disease classes that significantly overlaps with existing disease classification. In it, we find 14 disease-disease associations currently not present in Disease Ontology and provide evidence for their relationships through comorbidity data and literature curation. Interestingly, even though the number of known human genetic interactions is currently very small, we find they are the most important predictor of a link between diseases. Finally, we show that omission of any one of the included data sources reduces prediction quality, further highlighting the importance in the paradigm shift towards systems-level data fusion.

Evaluating the Link between Self-Esteem and Temperament in Mexican Origin Early Adolescents

ERIC Educational Resources Information Center

Robins, Richard W.; Donnellan, M. Brent; Widaman, Keith F.; Conger, Rand D.

2010-01-01

The present study examined the relation between self-esteem and temperament in a sample of 646 Mexican-American early adolescents (mean age = 10.4). Findings show that (a) early adolescents with high self-esteem exhibit higher levels of Effortful Control but, contrary to findings in adult samples, do not differ from low self-esteem adolescents in…

International Foundation for Functional Gastrointestinal Disorders

MedlinePlus

... Teens Manage Your Health Finding a Doctor The Digestive System Symptoms & Causes How to Prepare for Tests ... Part in Studies Resources Publications Library En Español Digestive Health Matters Medical Definitions Links Books of Interest ...

Cooperation and competition in business on example of Internet research of opto-electronic companies

NASA Astrophysics Data System (ADS)

Kaliczyńska, Małgorzata

2006-10-01

Based on findings from earlier studies which showed that links to academic web sites contain important information, the following study examines the practicability of using co-link data to describe cooperation and competition in optoelec-tronic business. The analysis was based on 32 companies and organizations which were found in an issue of a specialist magazine. For the purpose of the research three search engines - Google, Yahoo! and MSN Search were used. Assuming that a number of co-links to a pair of Web sites is a measure of the similarity between the two companies, the study aims at search for the sets of companies that would be similar to one another. The method applied is the MDS - multidimensional scaling that allows to present results of the analysis on a 2D map.

Links between parent characteristics and attachment variables for college students of parental divorce.

PubMed

Carranza, Laura V; Kilmann, Peter R; Vendemia, Jennifer M C

2009-01-01

This study investigated links between offsprings' attachment patterns and parent characteristics in 157 females and 62 males of parental divorce. Secure females and males reported affection, respect, and closeness toward both biological parents. Offsprings' insecure attachment pattern was associated with negative parent characteristics. Participants who perceived their same-sex parent negatively were more likely to report an insecure attachment. Our findings suggest delayed negative consequences of parental divorce for college women and men.

Literature Search through Mixed-Membership Community Discovery

NASA Astrophysics Data System (ADS)

Eliassi-Rad, Tina; Henderson, Keith

We introduce a new approach to literature search that is based on finding mixed-membership communities on an augmented co-authorship graph (ACA) with a scalable generative model. An ACA graph contains two types of edges: (1) coauthorship links and (2) links between researchers with substantial expertise overlap. Our solution eliminates the biases introduced by either looking at citations of a paper or doing a Web search. A case study on PubMed shows the benefits of our approach.

Robustness of chimera states in complex dynamical systems

PubMed Central

Yao, Nan; Huang, Zi-Gang; Lai, Ying-Cheng; Zheng, Zhi-Gang

2013-01-01

The remarkable phenomenon of chimera state in systems of non-locally coupled, identical oscillators has attracted a great deal of recent theoretical and experimental interests. In such a state, different groups of oscillators can exhibit characteristically distinct types of dynamical behaviors, in spite of identity of the oscillators. But how robust are chimera states against random perturbations to the structure of the underlying network? We address this fundamental issue by studying the effects of random removal of links on the probability for chimera states. Using direct numerical calculations and two independent theoretical approaches, we find that the likelihood of chimera state decreases with the probability of random-link removal. A striking finding is that, even when a large number of links are removed so that chimera states are deemed not possible, in the state space there are generally both coherent and incoherent regions. The regime of chimera state is a particular case in which the oscillators in the coherent region happen to be synchronized or phase-locked. PMID:24343533

Developmental experiences during extracurricular activities and Australian adolescents' self-concept: particularly important for youth from disadvantaged schools.

PubMed

Blomfield, Corey J; Barber, Bonnie L

2011-05-01

Extracurricular activities provide adolescents with a number of positive personal and interpersonal developmental experiences. This study investigated whether developmental experiences that occurred during extracurricular activities were linked to a more positive self-concept for Australian adolescents, and whether this link was particularly salient for youth from disadvantaged schools. Adolescents (N = 1,504, 56% Female) from 26 diverse high schools across Western Australia were surveyed. The findings revealed that adolescents from low socio-economic status schools who participated in extracurricular activities had a more positive general self-worth and social self-concept than adolescents from similar socio-economic schools who did not participate in any extracurricular activities. Furthermore, the positive developmental experiences that occurred during extracurricular activities predicted a more positive general self-worth and social and academic self-concept, and this link was stronger for youth from low SES schools. These findings suggest that the developmental experiences afforded by extracurricular activities may foster positive adolescent development.

A distributed algorithm to maintain and repair the trail networks of arboreal ants.

PubMed

Chandrasekhar, Arjun; Gordon, Deborah M; Navlakha, Saket

2018-06-18

We study how the arboreal turtle ant (Cephalotes goniodontus) solves a fundamental computing problem: maintaining a trail network and finding alternative paths to route around broken links in the network. Turtle ants form a routing backbone of foraging trails linking several nests and temporary food sources. This species travels only in the trees, so their foraging trails are constrained to lie on a natural graph formed by overlapping branches and vines in the tangled canopy. Links between branches, however, can be ephemeral, easily destroyed by wind, rain, or animal movements. Here we report a biologically feasible distributed algorithm, parameterized using field data, that can plausibly describe how turtle ants maintain the routing backbone and find alternative paths to circumvent broken links in the backbone. We validate the ability of this probabilistic algorithm to circumvent simulated breaks in synthetic and real-world networks, and we derive an analytic explanation for why certain features are crucial to improve the algorithm's success. Our proposed algorithm uses fewer computational resources than common distributed graph search algorithms, and thus may be useful in other domains, such as for swarm computing or for coordinating molecular robots.

Coparenting Conflict and Academic Readiness in Children of Teen Mothers: Effortful Control as a Mediator.

PubMed

Jahromi, Laudan B; Zeiders, Katharine H; Updegraff, Kimberly A; Umaña-Taylor, Adriana J; Bayless, Sara Douglass

2017-04-24

Children's exposure to coparenting conflict has important implications for their developmental functioning, yet limited work has focused on such processes in families with diverse structures or ethnically and culturally diverse backgrounds. This longitudinal study examined the processes by which Mexican-origin adolescent mothers' coparenting conflict with their 3-year-old children's grandmothers and biological fathers (N = 133 families) were linked to children's academic and social skills at 5 years of age, and whether children's effortful control at 4 years of age mediated the link between coparenting conflict and indices of children's academic readiness. Findings revealed that adolescent mothers' coparenting conflict with their child's biological father was linked to indices of children's academic and social school readiness through children's effortful control among girls, but not boys, whereas conflict with grandmothers was directly linked to boys' and girls' social functioning 2 years later. Findings offer information about different mechanisms by which multiple coparenting units in families of adolescent mothers are related to their children's outcomes, and this work has important implications for practitioners working with families of adolescent mothers. © 2017 Family Process Institute.

A Cross-Sectional Study of the Prevalence of Gastrointestinal Symptoms and Pathology in Patients With Common Variable Immunodeficiency.

PubMed

Jørgensen, Silje F; Reims, Henrik M; Frydenlund, Didrik; Holm, Kristian; Paulsen, Vemund; Michelsen, Annika E; Jørgensen, Kristin K; Osnes, Liv T; Bratlie, Jorunn; Eide, Tor J; Dahl, Christen P; Holter, Ellen; Tronstad, Rune R; Hanevik, Kurt; Brattbakk, Hans-Richard; Kaveh, Fatemeh; Fiskerstrand, Torunn; Kran, Anne-Marte B; Ueland, Thor; Karlsen, Tom H; Aukrust, Pål; Lundin, Knut E A; Fevang, Børre

2016-10-01

The objective of this study was to study the prevalence of gastrointestinal (GI) symptoms and histopathology in patients with common variable immunodeficiency (CVID) as well as linking the findings to GI infections and markers of systemic immune activation. In this cross-sectional study, we addressed GI symptoms in 103 patients and GI histopathological findings in 53 patients who underwent upper and lower endoscopic examination. The most frequent histopathological findings were linked to GI symptoms, B-cell phenotype, and markers of systemic immune activation (soluble (s)CD14, sCD25, and sCD163). Microarray analysis compared "celiac-like disease" in CVID to celiac disease. Screening for selected bacterial and viral infections in fecal samples and gut mucosal biopsies was performed. The main findings of this study were as follows: most common GI symptoms were bloating (34%), pain (30%), and diarrhea (26%). The most frequent histopathological findings were increased intraepithelial lymphocytes in the descending part of the duodenum, i.e., "celiac-like disease" (46% of patients), decreased numbers of plasma cells in GI tract mucosa (62%), and lymphoid hyperplasia (38%), none of which were associated with GI symptoms. Reduced plasma cells in GI mucosa were associated with B-cell phenotypic characteristics of CVID, and increased serum levels of sCD14 (P=0.025), sCD25 (P=0.01), and sCD163 (P=0.04). Microarray analyses distinguished between CVID patients with "celiac-like disease" and celiac disease. Positive tests for bacterial and viral infections were scarce both in fecal samples and gut mucosal biopsies, including PCR test for norovirus in biopsy specimens (0 positive tests). In conclusion, GI pathology is common in CVID, but does not necessarily cause symptoms. However, reduced plasma cells in GI mucosa were linked to systemic immune activation, "celiac-like disease" in CVID and true celiac disease appear to be different disease entities, as assessed by gene expression, and infections (including norovirus) are rarely a cause of the CVID enteropathy.

Biodiversity and disease: a synthesis of ecological perspectives on Lyme disease transmission.

PubMed

Wood, Chelsea L; Lafferty, Kevin D

2013-04-01

Recent reviews have argued that disease control is among the ecosystem services yielded by biodiversity. Lyme disease (LD) is commonly cited as the best example of the 'diluting' effect of biodiversity on disease transmission, but many studies document the opposite relationship, showing that human LD risk can increase with forestation. Here, we unify these divergent perspectives and find strong evidence for a positive link between biodiversity and LD at broad spatial scales (urban to suburban to rural) and equivocal evidence for a negative link between biodiversity and LD at varying levels of biodiversity within forests. This finding suggests that, across zoonotic disease agents, the biodiversity-disease relationship is scale dependent and complex. Copyright © 2012 Elsevier Ltd. All rights reserved.

Maximizing synchronizability of duplex networks

NASA Astrophysics Data System (ADS)

Wei, Xiang; Emenheiser, Jeffrey; Wu, Xiaoqun; Lu, Jun-an; D'Souza, Raissa M.

2018-01-01

We study the synchronizability of duplex networks formed by two randomly generated network layers with different patterns of interlayer node connections. According to the master stability function, we use the smallest nonzero eigenvalue and the eigenratio between the largest and the second smallest eigenvalues of supra-Laplacian matrices to characterize synchronizability on various duplexes. We find that the interlayer linking weight and linking fraction have a profound impact on synchronizability of duplex networks. The increasingly large inter-layer coupling weight is found to cause either decreasing or constant synchronizability for different classes of network dynamics. In addition, negative node degree correlation across interlayer links outperforms positive degree correlation when most interlayer links are present. The reverse is true when a few interlayer links are present. The numerical results and understanding based on these representative duplex networks are illustrative and instructive for building insights into maximizing synchronizability of more realistic multiplex networks.

Prospective links between ethnic socialization, ethnic and American identity, and well-being among Asian-American adolescents.

PubMed

Gartner, Meaghan; Kiang, Lisa; Supple, Andrew

2014-10-01

Ethnic socialization and ethnic identity have been related to positive outcomes, but little research has examined these associations longitudinally. This three-wave study prospectively linked socialization messages at Time 1, ethnic identity and American identity at Time 2, and self-esteem and depressive symptoms at Time 3 in 147 (58% female; 25% first-generation) Asian-American adolescents. The results indicated positive links between cultural socialization messages and ethnic and American identity, though the latter association was significant only for females. Ethnic identity was positively related to self-esteem, and mediated the positive effect of cultural socialization on self-esteem. The promotion of mistrust was positively linked to self-esteem and negatively related to ethnic identity, though this latter association was significant for foreign-born youth only. Our findings highlight the importance of elucidating prospective links in identity development, and examining gender and generational differences within them.

Breastfeeding, Parenting, and Infant Attachment Behaviors.

PubMed

Gibbs, Benjamin G; Forste, Renata; Lybbert, Emily

2018-04-01

Objectives Infants and toddlers need secure attachments in order to develop the social competence required to successfully navigate later peer and adult relationships. Breastfeeding is a parenting factor that has been associated with child emotional development-specifically the attachment between children and their mothers. Yet, this link may simply be the result of other parenting behaviors that are associated with breastfeeding. Thus, our objective is to examine whether the link between infant attachment behaviors and breastfeeding endures when accounting for a broad array of in-depth measures of parenting. Methods We use the Early Childhood Longitudinal Study of children from 9 months to 2 years of age collected by the National Center for Education Statistics. Using Ordinary Least Squares regression, data analyses examine the association between the Toddler Attachment Sort-45 (TAS-45) measures of toddler-parent attachment (infant attachment security and temperamental dependency) and breastfeeding practices. We also examine individual items of the TAS-45 to isolate specific attachment behaviors that have the strongest associations with breastfeeding. Results We find an enduring link between children who are predominantly breastfed for six or more months and infant attachment security. However, we find no evidence that breastfeeding is linked to a child's temperamental dependency. Of the nine items used to examine infant attachment behaviors, we find that breastfed children are rated as having slightly higher scores on two measures ("warm and cuddly," "cooperative") and lower scores on one measure ("demanding/angry"). Conclusions for Practice Breastfeeding has an important link to the child's use of their caregiver as a secure base for exploration and a place of comfort when distressed (infant attachment security). Yet, breastfeeding does not appear to reduce a child's temperamental dependency or level of clinginess as measured by how demanding, fussy or distressed the child becomes when separated.

Analysis of an international collaboration for capacity building of human resources for eye care: case study of the college-college VISION 2020 LINK.

PubMed

Mwangi, Nyawira; Zondervan, Marcia; Bascaran, Covadonga

2017-03-14

There is an extreme health workforce shortage in Eastern, Central, and Southern Africa. Shortage of eye care workers impedes effective implementation of prevention of blindness programs. The World Health Organization has identified education, partnership, leadership, financing, and policy as intertwined interventions that are critical to resolving this crisis on the long term. The VISION 2020 LINK between the College of Ophthalmology of Eastern, Central, and Southern Africa and the Royal College of Ophthalmologists in the United Kingdom aims to increase the quantity and quality of eye care training in East, Central, and Southern Africa through a focus on five strategic areas: fellowship examination for ophthalmologists, training the trainers, curriculum development for residents in ophthalmology and ophthalmic clinical officers, continuous professional development (CPD), and mentoring program for young ophthalmologists. This study examined how education and partnership can be linked to improve eye care, through an evaluation of this north-south link based on its own targets and established frameworks to guide north-south links. An exploratory qualitative case study design was used. Twenty-nine link representatives were recruited through purposive sampling and snowballing. Face-to-face interviews were conducted using a semi-structured interview schedule that incorporated the components of a successful link from an existing framework. Documents pertaining to the link were also examined. Thematic analysis was used for data analysis. The findings revealed that the perception to the contribution of the link to eye care in the region is generally positive. Process indicators showed that the targets in three strategic objectives of the link have been achieved. Framework-based evaluation also showed that the link is successful. Mutual learning and development of friendships were the most commonly identified success factors. Inadequate awareness of the link by college members is a key challenge. The study concludes that the link is active and evolving and has achieved most of its targets. Further developments should be directed to influence health system strengthening in Eastern, Central, and Southern Africa more strategically. The study recommends expansion of the scope of collaboration to involve multiple health system building blocks.

Understanding the Link Between Pubertal Timing in Girls and the Development of Depressive Symptoms: The Role of Sexual Harassment.

PubMed

Skoog, Therése; Bayram Özdemir, Sevgi; Stattin, Håkan

2016-02-01

The link between sexual maturation, or pubertal timing, in girls and adolescent depressive symptoms is well-documented, but the underlying processes remain unclear. We examined whether sexual harassment, which has previously been linked to both pubertal timing and depressive symptoms, mediates this link, using a two-wave longitudinal study including 454 girls in 7th (M age  = 13.42, SD = .53) and 8th grade (M age  = 14.42, SD = .55). Pubertal timing was linked to depressive symptoms in both age groups, and predicted an increase in depressive symptoms among the 7th graders. Sexual harassment significantly mediated the link between pubertal timing and depressive symptoms among the 7th, but not the 8th grade girls. Together, our findings suggest that one way to prevent depressive symptoms among early-maturing girls could be to address sexual harassment in preventive intervention in early adolescence.

Discovering Link Communities in Complex Networks by an Integer Programming Model and a Genetic Algorithm

PubMed Central

Li, Zhenping; Zhang, Xiang-Sun; Wang, Rui-Sheng; Liu, Hongwei; Zhang, Shihua

2013-01-01

Identification of communities in complex networks is an important topic and issue in many fields such as sociology, biology, and computer science. Communities are often defined as groups of related nodes or links that correspond to functional subunits in the corresponding complex systems. While most conventional approaches have focused on discovering communities of nodes, some recent studies start partitioning links to find overlapping communities straightforwardly. In this paper, we propose a new quantity function for link community identification in complex networks. Based on this quantity function we formulate the link community partition problem into an integer programming model which allows us to partition a complex network into overlapping communities. We further propose a genetic algorithm for link community detection which can partition a network into overlapping communities without knowing the number of communities. We test our model and algorithm on both artificial networks and real-world networks. The results demonstrate that the model and algorithm are efficient in detecting overlapping community structure in complex networks. PMID:24386268

Measuring the value of accurate link prediction for network seeding.

PubMed

Wei, Yijin; Spencer, Gwen

2017-01-01

The influence-maximization literature seeks small sets of individuals whose structural placement in the social network can drive large cascades of behavior. Optimization efforts to find the best seed set often assume perfect knowledge of the network topology. Unfortunately, social network links are rarely known in an exact way. When do seeding strategies based on less-than-accurate link prediction provide valuable insight? We introduce optimized-against-a-sample ([Formula: see text]) performance to measure the value of optimizing seeding based on a noisy observation of a network. Our computational study investigates [Formula: see text] under several threshold-spread models in synthetic and real-world networks. Our focus is on measuring the value of imprecise link information. The level of investment in link prediction that is strategic appears to depend closely on spread model: in some parameter ranges investments in improving link prediction can pay substantial premiums in cascade size. For other ranges, such investments would be wasted. Several trends were remarkably consistent across topologies.

Early maternal employment and children's school readiness in contemporary families.

PubMed

Lombardi, Caitlin McPherran; Coley, Rebekah Levine

2014-08-01

This study assessed whether previous findings linking early maternal employment to lower cognitive and behavioral skills among children generalized to modern families. Using a representative sample of children born in the United States in 2001 (N = 10,100), ordinary least squares regression models weighted with propensity scores assessed links between maternal employment in the 2 years after childbearing and children's school readiness skills at kindergarten. There were neutral associations between maternal employment and children's school readiness, which were not differentiated by maternal time, stress, or wages. However, as nonmaternal household income decreased, maternal employment begun prior to 9 months was linked with higher cognitive skills, while employment begun between 9 and 24 months was linked with lower conduct problems. PsycINFO Database Record (c) 2014 APA, all rights reserved.

Susceptibility of the individual caseins in reconstituted skim milk to cross-linking by transglutaminase: influence of temperature, pH and mineral equilibria.

PubMed

Hinz, Katharina; Huppertz, Thom; Kelly, Alan L

2012-11-01

The susceptibility of total casein and the individual caseins in reconstituted skim milk to transglutaminase (TGase)-induced cross-linking was studied as a function of incubation temperature (5-40 °C), pH (5·0-7·0) and mineral addition. Within the ranges studied, the level of total casein cross-linked increased with increasing temperature, pH and concentration of added trisodium citrate, whereas adding calcium chloride had the opposite effect. These effects can be largely related to the effects of these parameters on TGase activity. In addition, the parameters were also found to influence the susceptibility of κ-casein, and to a lesser extent β-casein, to cross-linking, whereas the susceptibility of αs1-casein was not affected. The susceptibility of κ-casein to cross-linking increased with increasing temperature and calcium chloride addition, but decreased with increasing pH and citrate content, whereas the susceptibility of β-casein to TGase-induced cross-linking decreased with increasing temperature, but was not affected by other parameters. These findings highlight the fact that selection of environmental conditions during cross-linking can be applied to tailor the surface, and hence possibly colloidal stability, of casein micelles in TGase-treated milk.

Sissiness, tomboyism, sex-role, sex identity and orientation.

PubMed

McConaghy, N; Zamir, R

1995-06-01

Masculinity and femininity have been studied by self-ratings in independent areas of research: one investigating personality traits considered masculine (M) or feminine (F); the other, behaviours statistically more common in one than in the other sex (sex-linked behaviours). The two approaches were compared for the first time in the present study of 66 male and 51 female medical students. Consistent with previous findings using the second approach, male but not female subjects' opposite sex-linked "sissy" and "tomboyish" behaviours correlated significantly with their reported ratio of homosexual to heterosexual feelings (Ho/Het). Ho/Het did not correlate with either sex's M and F scores, but high M scores in women correlated strongly with several "tomboyish" behaviours. As "tomboyish" behaviours are shown more strongly by women exposed prenatally to increased levels of opposite sex hormones compared to controls, the findings have implications for the biological theory attributing Ho/Het to such prenatal hormonal exposure.

Love withdrawal predicts electrocortical responses to emotional faces with performance feedback: a follow-up and extension.

PubMed

Huffmeijer, Renske; Bakermans-Kranenburg, Marian J; Alink, Lenneke R A; van IJzendoorn, Marinus H

2014-06-02

Parental use of love withdrawal is thought to affect children's later psychological functioning because it creates a link between children's performance and relational consequences. In addition, recent studies have begun to show that experiences of love withdrawal also relate to the neural processing of socio-emotional information relevant to a performance-relational consequence link, and can moderate effects of oxytocin on social information processing and behavior. The current study follows-up on our previous results by attempting to confirm and extend previous findings indicating that experiences of maternal love withdrawal are related to electrocortical responses to emotional faces presented with performance feedback. More maternal love withdrawal was related to enhanced early processing of facial feedback stimuli (reflected in more positive VPP amplitudes, and confirming previous findings). However, attentional engagement with and processing of the stimuli at a later stage were diminished in those reporting higher maternal love withdrawal (reflected in less positive LPP amplitudes, and diverging from previous findings). Maternal love withdrawal affects the processing of emotional faces presented with performance feedback differently in different stages of neural processing.

Adrenoleukodystrophy. Electron microscopic findings.

PubMed

Powell, H; Tindall, R; Schultz, P; Paa, D; O'Brien, J; Lampert, P

1975-04-01

Ultrastructural and neurochemical studies were done on three male patients with adrenoleukodystrophy. In each case, the affected white matter contained enlarged glial cells filled with pathognomic intracytoplasmic inclusions consisting of electron-lucent spicules bounded by 25-Angstrom wide membranes. Similar inclusions were present in adrenocortical cells. These findings and a review of 47 reported cases indicate that adrenoleukodystrophy is a storage disorder caused by a sex-linked recessive error of metabolism.

Study Links Learning Design to Changes in Knowledge, Beliefs, and Behaviors. Lessons from Research

ERIC Educational Resources Information Center

Killion, Joellen

2015-01-01

In this study of 16 teachers in two primary schools in the Netherlands, researchers built on findings from previous studies to demonstrate that a thoughtfully designed professional development program can be "effective and sustainable, if certain conditions are met" (p. 772) in changing teachers' knowledge, beliefs, perceived problems,…

Increasing Parent Involvement in Youth HIV Prevention: A Randomized Caribbean Study

ERIC Educational Resources Information Center

Baptiste, Donna R.; Kapungu, Chisina; Miller, Steve; Crown, Laurel; Henry, David; Da Costa Martinez, Dona; Jo-Bennett, Karen

2009-01-01

This article presents preliminary findings of a randomized HIV prevention study in Trinidad and Tobago in the Caribbean. The study centers on a family HIV workshop aimed at strengthening parenting skills that are empirically linked to reducing adolescent HIV exposure and other sexual risks. These skills include parental monitoring; educating youth…

Crosslinked, porous, polyacrylate beads

NASA Technical Reports Server (NTRS)

Rembaum, Alan (Inventor); Yen, Shiao-Ping Siao (Inventor); Dreyer, William J. (Inventor)

1976-01-01

Uniformly-shaped, porous, round beads are prepared by the co-polymerization of an acrylic monomer and a cross-linking agent in the presence of 0.05 to 5% by weight of an aqueous soluble polymer such as polyethylene oxide. Cross-linking proceeds at high temperature above about 50.degree.C or at a lower temperature with irradiation. Beads of even shape and even size distribution of less than 2 micron diameter are formed. The beads will find use as adsorbents in chromatography and as markers for studies of cell surface receptors.

Crosslinked, porous, polyacrylate beads

NASA Technical Reports Server (NTRS)

Rembaum, Alan (Inventor); Yen, Shiao-Ping S. (Inventor); Dreyer, William J. (Inventor)

1977-01-01

Uniformly-shaped, porous, round beads are prepared by the co-polymerization of an acrylic monomer and a cross-linking agent in the presence of 0.05 to 5% by weight of an aqueous soluble polymer such as polyethylene oxide. Cross-linking proceeds at high temperature above about 50.degree. C or at a lower temperature with irradiation. Beads of even shape and even size distribution of less than 2 micron diameter are formed. The beads will find use as adsorbents in chromatography and as markers for studies of cell surface receptors.

Small, porous polyacrylate beads

NASA Technical Reports Server (NTRS)

Yen, Shiao-Ping Siao (Inventor); Rembaum, Alan (Inventor); Dreyer, William J. (Inventor)

1976-01-01

Uniformly-shaped, porous, round beads are prepared by the co-polymerization of an acrylic monomer and a cross-linking agent in the presence of 0.05 to 5% by weight of an aqueous soluble polymer such as polyethylene oxide. Cross-linking proceeds at high temperature above about 50.degree.C or at a lower temperature with irradiation. Beads of even shape and even size distribution of less than 2 micron diameter are formed. The beads will find use as adsorbents in chromatography and as markers for studies of cell surface receptors.

High-Stakes Systematic Reviews: A Case Study From the Field of Teen Pregnancy Prevention.

PubMed

Goesling, Brian; Oberlander, Sarah; Trivits, Lisa

2016-08-19

Systematic reviews help policy makers and practitioners make sense of research findings in a particular program, policy, or practice area by synthesizing evidence across multiple studies. However, the link between review findings and practical decision-making is rarely one-to-one. Policy makers and practitioners may use systematic review findings to help guide their decisions, but they may also rely on other information sources or personal judgment. To describe a recent effort by the U.S. federal government to narrow the gap between review findings and practical decision-making. The Teen Pregnancy Prevention (TPP) Evidence Review was launched by the U.S. Department of Health and Human Services (HHS) in 2009 as a systematic review of the TPP literature. HHS has used the review findings to determine eligibility for federal funding for TPP programs, marking one of the first attempts to directly link systematic review findings with federal funding decisions. The high stakes attached to the review findings required special considerations in designing and conducting the review. To provide a sound basis for federal funding decisions, the review had to meet accepted methodological standards. However, the review team also had to account for practical constraints of the funding legislation and needs of the federal agencies responsible for administering the grant programs. The review team also had to develop a transparent process for both releasing the review findings and updating them over time. Prospective review authors and sponsors must recognize both the strengths and limitations of this approach before applying it in other areas. © The Author(s) 2016.

How Should Debriefing Be Undertaken in Web-Based Studies? Findings From a Randomized Controlled Trial

PubMed Central

Kypri, Kypros; Wilson, Amanda

2012-01-01

Background Internet research may raise older ethical issues in new forms or pose new issues. It has been recommended that debriefing information online be kept very short, with further information including study results made available if requested by participants. There are no empirical studies that compare possible alternative methods of debriefing in online studies. Objective To undertake a randomized controlled trial evaluating how to implement the recommended approach by assessing the effects of two different approaches on accessing of additional information. Methods All 11,943 participants in the Effects of Study Design and Allocation (ESDA) study, which employed deception, were randomly assigned to one of two methods of debriefing: Group A received the debriefing information in the body of an email with links to protocol and results pages; Group B was presented with these links after clicking on an initial link in the body of the email to view the debriefing information on a website. Outcomes assessed were the proportions clicking on the links to the protocol and results summary and the time spent on these pages by those accessing them. Results The group who were presented with no debriefing information in the body of the email and went to a website for this information (Group B) were approximately twice as likely to subsequently access the protocol and the results summary. These differences between the two groups were highly statistically significant. Although these differences are clear, the overall proportions accessing such information were low, and there were no differences in mean time spent reading these pages. Only one quarter of Group B actually accessed debriefing information. Conclusions In circumstances where the uptake of fuller information on study design, methods, and findings is deemed important, debriefing information may be better provided via a link and not included in the body of an email. Doing so may, however, reduce the extent of receiving any debriefing information at all. There is a wider need for high quality empirical studies to inform ethical evaluations. Trial Registration Australian New Zealand Clinical Trials Registry, ACTRN12610000846022 (http://www.anzctr.org.au/) PMID:23160103

An Attentional Application of Socioemotional Selectivity Theory in College Students

ERIC Educational Resources Information Center

Pruzan, Katherine; Isaacowitz, Derek M.

2006-01-01

Socioemotional selectivity theory posits that emotions become increasingly salient as individuals approach endings. Recent findings have linked the theory with biases in information processing in the context of aging. However, these studies all confounded advancing age and the motivational impact of endings. This study represented an attempt to…

Personality Disorder Symptoms and Marital Functioning

ERIC Educational Resources Information Center

South, Susan C.; Turkheimer, Eric; Oltmanns, Thomas F.

2008-01-01

Pathological personality is strongly linked with interpersonal impairment, yet no study to date has examined the relationship between concurrent personality pathology and dysfunction in marriage--a relationship that most people find central to their lives. In a cross-sectional study of a community sample of married couples (N = 82), the authors…

Do Mothers' Educational Expectations Differ by Race and Ethnicity, or Socioeconomic Status?

ERIC Educational Resources Information Center

Kim, Youngmi; Sherraden, Michael; Clancy, Margaret

2013-01-01

Research has linked parents' educational expectations to children's educational attainment, but findings are inconsistent regarding differences in educational expectations by race and ethnicity. In addition, existing studies have focused on school-age children and their parents. In this study, we use a state representative sample to examine…

Identity Statuses in Upper-Division Physics Students

ERIC Educational Resources Information Center

Irving, Paul W.; Sayre, Eleanor C.

2016-01-01

We use the theories of identity statuses and communities of practice to describe three different case studies of students finding their paths through undergraduate physics and developing a physics subject-specific identity. Each case study demonstrates a unique path that reinforces the link between the theories of communities of practice and…

Navigation To and From a Page: Which Links Get Clicked From Where

EPA Pesticide Factsheets

Use Google Analytics navigation summary data to find out what page users most frequently click your Contact Us link from (Previous Page Path), or which links on your homepage are popular or unpopular (Next Page Path).

A new estimate of the impact of OSHA inspections on manufacturing injury rates, 1998-2005.

PubMed

Haviland, Amelia M; Burns, Rachel M; Gray, Wayne B; Ruder, Teague; Mendeloff, John

2012-11-01

A prior study indicated that the effect of OSHA inspections on lost workday injuries had declined from 1979 through 1998. This study provides an updated estimate for 1998-2005. Injury data from the Pennsylvania workers' compensation program were linked with employment data from unemployment compensation records to calculate lost-time rates for single-establishment manufacturing firms with more than 10 employees. These rates were linked to OSHA inspection findings. The RAND Human Subjects Protection Committee determined that this study was exempt from review. Inspections with penalties reduced injuries by an average of 19-24% annually in the 2 years following the inspection. These effects were not found for workplaces with fewer than 20 or more than 250 employees or for inspections without penalties. These findings should be generalizable to the 29 states where federal OSHA directly enforces standards. They suggest that the impact of inspections has increased from the 1990s. Copyright © 2012 Wiley Periodicals, Inc.

Automated linking of suspicious findings between automated 3D breast ultrasound volumes

NASA Astrophysics Data System (ADS)

Gubern-Mérida, Albert; Tan, Tao; van Zelst, Jan; Mann, Ritse M.; Karssemeijer, Nico

2016-03-01

Automated breast ultrasound (ABUS) is a 3D imaging technique which is rapidly emerging as a safe and relatively inexpensive modality for screening of women with dense breasts. However, reading ABUS examinations is very time consuming task since radiologists need to manually identify suspicious findings in all the different ABUS volumes available for each patient. Image analysis techniques to automatically link findings across volumes are required to speed up clinical workflow and make ABUS screening more efficient. In this study, we propose an automated system to, given the location in the ABUS volume being inspected (source), find the corresponding location in a target volume. The target volume can be a different view of the same study or the same view from a prior examination. The algorithm was evaluated using 118 linkages between suspicious abnormalities annotated in a dataset of ABUS images of 27 patients participating in a high risk screening program. The distance between the predicted location and the center of the annotated lesion in the target volume was computed for evaluation. The mean ± stdev and median distance error achieved by the presented algorithm for linkages between volumes of the same study was 7.75±6.71 mm and 5.16 mm, respectively. The performance was 9.54±7.87 and 8.00 mm (mean ± stdev and median) for linkages between volumes from current and prior examinations. The proposed approach has the potential to minimize user interaction for finding correspondences among ABUS volumes.

"Selling It as a Holistic Health Provision and Not Just about Condoms..." Sexual Health Services in School Settings: Current Models and Their Relationship with Sex and Relationships Education Policy and Provision

ERIC Educational Resources Information Center

Formby, Eleanor; Hirst, Julia; Owen, Jenny; Hayter, Mark; Stapleton, Helen

2010-01-01

In this article we discuss the findings from a recent study of UK policy and practice in relation to sexual health services for young people, based in--or closely linked with--schools. This study formed part of a larger project, completed in 2009, which also included a systematic review of international research. The findings discussed in this…

Statistical link between external climate forcings and modes of ocean variability

NASA Astrophysics Data System (ADS)

Malik, Abdul; Brönnimann, Stefan; Perona, Paolo

2017-07-01

In this study we investigate statistical link between external climate forcings and modes of ocean variability on inter-annual (3-year) to centennial (100-year) timescales using de-trended semi-partial-cross-correlation analysis technique. To investigate this link we employ observations (AD 1854-1999), climate proxies (AD 1600-1999), and coupled Atmosphere-Ocean-Chemistry Climate Model simulations with SOCOL-MPIOM (AD 1600-1999). We find robust statistical evidence that Atlantic multi-decadal oscillation (AMO) has intrinsic positive correlation with solar activity in all datasets employed. The strength of the relationship between AMO and solar activity is modulated by volcanic eruptions and complex interaction among modes of ocean variability. The observational dataset reveals that El Niño southern oscillation (ENSO) has statistically significant negative intrinsic correlation with solar activity on decadal to multi-decadal timescales (16-27-year) whereas there is no evidence of a link on a typical ENSO timescale (2-7-year). In the observational dataset, the volcanic eruptions do not have a link with AMO on a typical AMO timescale (55-80-year) however the long-term datasets (proxies and SOCOL-MPIOM output) show that volcanic eruptions have intrinsic negative correlation with AMO on inter-annual to multi-decadal timescales. The Pacific decadal oscillation has no link with solar activity, however, it has positive intrinsic correlation with volcanic eruptions on multi-decadal timescales (47-54-year) in reconstruction and decadal to multi-decadal timescales (16-32-year) in climate model simulations. We also find evidence of a link between volcanic eruptions and ENSO, however, the sign of relationship is not consistent between observations/proxies and climate model simulations.

Residential Mobility, Self-Concept, and Positive Affect in Social Interactions

PubMed Central

Oishi, Shigehiro; Lun, Janetta; Sherman, Gary D.

2008-01-01

The present research examined (a) the link between personal history of residential mobility and the self-concept and (b) the implications of such a link for positive affect in social interactions. Study 1 showed that the personal self was more central to the self-definition of frequent movers than to that of nonmovers, whereas the collective self was more central to the self-definition of nonmovers than to that of frequent movers. Results from a laboratory and a 2-week event sampling study (Studies 2 and 3) demonstrated that frequent movers felt happier when an interaction partner accurately perceived their personal selves, whereas nonmovers felt happier when a partner accurately perceived their collective selves. These findings present the first direct evidence on how personal history of residential mobility is linked to important individual differences in the self and positive affect in social interactions. PMID:17605594

Developmental Pathways from Child Maltreatment to Adolescent Substance Use: The Roles of Posttraumatic Stress Symptoms and Mother-Child Relationships

PubMed Central

Yoon, Susan; Kobulsky, Julia M.; Yoon, Dalhee; Kim, Wonhee

2018-01-01

While many studies have identified a significant relation between child maltreatment and adolescent substance use, the developmental pathways linking this relation remain sparsely explored. The current study examines posttraumatic stress (PTS) symptoms, mother-child relationships, and internalizing and externalizing problems as potential longitudinal pathways through which child maltreatment influences adolescent substance use. Structural equation modeling was conducted on 883 adolescents drawn from the Longitudinal Studies of Child Abuse and Neglect (LONGSCAN). The pathways of PTS symptoms linked physical and sexual abuse to substance use, and the pathways of mother-child relationships linked emotional abuse and neglect to substance use. None of the four types of maltreatment affected substance use via internalizing or externalizing problems. The findings suggest that intervention efforts aimed at addressing posttraumatic stress symptoms and improving mother-child relationship quality may be beneficial in reducing substance use among adolescents with child maltreatment histories. PMID:29503490

Residential mobility, self-concept, and positive affect in social interactions.

PubMed

Oishi, Shigehiro; Lun, Janetta; Sherman, Gary D

2007-07-01

The present research examined (a) the link between personal history of residential mobility and the self-concept and (b) the implications of such a link for positive affect in social interactions. Study 1 showed that the personal self was more central to the self-definition of frequent movers than to that of nonmovers, whereas the collective self was more central to the self-definition of nonmovers than to that of frequent movers. Results from a laboratory and a 2-week event sampling study (Studies 2 and 3) demonstrated that frequent movers felt happier when an interaction partner accurately perceived their personal selves, whereas nonmovers felt happier when a partner accurately perceived their collective selves. These findings present the first direct evidence on how personal history of residential mobility is linked to important individual differences in the self and positive affect in social interactions. Copyright 2007 APA, all rights reserved.

Business structure, ethnic shifts in labor markets, and violence: the link between company size, local labor markets, and non-Latino homicide.

PubMed

Barranco, Raymond E; Shihadeh, Edward S

2015-01-01

Combining several schools of thought, including the civic engagement thesis, we extend current research by linking three things at the county level; firm size, the ethnic composition of labor markets, and violent crime. Our results suggest that larger businesses (based on the average number of persons employed) are more likely to have an external orientation and long recruitment reach, and this is linked to ethnic shifts in labor markets toward Latino workers. Such shifts are in turn associated with high rates of homicide among non-Latinos. Through indirect effects modeling, we find that increases in Black homicide are linked to rises in concentrated poverty, while increases in White homicide are linked to changes in unemployment. We discuss the implications of our findings. Copyright © 2014 Elsevier Inc. All rights reserved.

Immunoglobulin subunits of murine B lymphocytes: structure and associations with other membrane proteins.

PubMed Central

Vogel, L; Haustein, D

1989-01-01

The Ig subunit structure of murine B lymphocytes was studied by employing different radiolabelling techniques in combination with chemical cross-linking. The main membrane structure of IgM was a half molecule that was disulphide-linked to proteins with MW 30,000, 45,000 and 55,000, respectively. Small amounts of mu 2L2, microL disulphide-linked to a protein with MW 50,000, and free microL were also detected. The main IgD structures were half molecules disulphide-linked to two proteins with MW 14,000 and two proteins with MW 16,000. Furthermore, IgD half molecules disulphide-linked to a protein with MW 16,000 and free half molecules could be demonstrated. Labelling with hydrophobic reagents showed that all Ig molecules and the protein with MW 50,000, linked to microL, penetrated the lipid bilayer, whereas the other IgM- and IgD-linked proteins probably did not. Additional proteins which were associated exclusively with IgM were detected by chemical cross-linking. These findings offer new possibilities for the investigation of the function(s) of antigen receptors on B cells. Images Figure 1 Figure 2 Figure 4 Figure 5 PMID:2787780

Poverty, inequality, and increased consumption of high calorie food: Experimental evidence for a causal link.

PubMed

Bratanova, Boyka; Loughnan, Steve; Klein, Olivier; Claassen, Almudena; Wood, Robert

2016-05-01

Rising obesity represents a serious, global problem. It is now well established that obesity is associated with poverty and wealth inequality, suggesting that these factors may promote caloric intake. Whereas previous work has examined these links from an epidemiological perspective, the current paper examined them experimentally. In Study 1 we found that people experimentally induced to view themselves as poor (v. wealthy) exhibited increased calorie intake. In Study 2, participants who believed that they were poorer or wealthier than their interaction partners exhibited higher levels of anxiety compared to those in an equal partners condition; this anxiety in turn led to increased calorie consumption for people who had a strong need to belong. The findings provide causal evidence for the poverty-intake and inequality-intake links. Further, we identify social anxiety and a strong need to belong as important social psychological factors linking inequality to increased calorie intake. Copyright © 2016. Published by Elsevier Ltd.

Evaluation of super-link system theory for spinal cord injury patients using participatory action research in a rehabilitation hospital.

PubMed

Chen, Hsiao-Yu; Wu, Tzu-Jung; Cheng, Mei-Li; Sung, Hsi-Hui

2012-01-01

The purpose of this study was to integrate and evaluate the spinal cord injury rehabilitation nursing theory named Super-Link System Theory using participatory action research. Data were collected from October 2007 to September 2008 in a rehabilitation hospital by means of interviews, participant observations, documentary resources, case conferences and reports, and participants' self-reflective inquiries. The Super-Link System Theory was introduced to 31 rehabilitation nurses. The nurses selected a key reference group including the researcher to facilitate the participatory action research process to implement and evaluate the theory. Data were analyzed using content analysis. The findings shows that several key concepts were clarified and specific nursing interventions were identified. Furthermore, an integrated link system from the hospital to the community through both rehabilitation nurses and discharge planners was established. The study demonstrated an evidence base for an evolving theory of care, and empowered nurses to make sustainable changes to their practice. © 2012 Association of Rehabilitation Nurses.

Socioeconomic Factors and Leukocyte Telomere Length In A Multi-Ethnic Sample: Findings From The Multi-Ethnic Study of Atherosclerosis (MESA)

PubMed Central

Carroll, Judith E.; Diez-Roux, Ana V.; Adler, Nancy E.; Seeman, Teresa E.

2012-01-01

Previous findings have linked lower socioeconomic status (SES) with elevated morbidity and mortality. Leukocyte telomere length (LTL), which also has been associated with age-related disease morbidity and mortality, is a marker of aging at the cellular level, making it a valuable early biomarker of risk and an indicator of biological age. It is hypothesized that SES will be associated with LTL, indicating that SES influences disease risk by accelerating biological aging. In the present sample we test for associations of childhood SES and adult SES (i.e. education, income, home ownership) with LTL, and examine whether these associations vary by racial/ethnic group. Analyses on 963 subjects (18.7% White, 53% Hispanics, and 28.5% African American) from the Stress ancillary study of the Multi-Ethnic Study of Atherosclerosis revealed a significant difference in LTL between home owners and renters in Hispanic and White participants (p < .05), but not amongst African Americans (p = .98). There were no linear associations of adult education or family income with LTL, however, there was an inverse association between father’s education and LTL (p = .03). These findings suggest that for Whites and Hispanics renting vs. owning a home is associated with an older biological age; however we did not replicate previous findings linking education with LTL. PMID:23142704

Models, Strategies, and Tools: Theory in Implementing Evidence-Based Findings into Health Care Practice

PubMed Central

Sales, Anne; Smith, Jeffrey; Curran, Geoffrey; Kochevar, Laura

2006-01-01

This paper presents a case for careful consideration of theory in planning to implement evidence-based practices into clinical care. As described, theory should be tightly linked to strategic planning through careful choice or creation of an implementation framework. Strategies should be linked to specific interventions and/or intervention components to be implemented, and the choice of tools should match the interventions and overall strategy, linking back to the original theory and framework. The thesis advanced is that in most studies where there is an attempt to implement planned change in clinical processes, theory is used loosely. An example of linking theory to intervention design is presented from a Mental Health Quality Enhancement Research Initiative effort to increase appropriate use of antipsychotic medication among patients with schizophrenia in the Veterans Health Administration. PMID:16637960

Models, strategies, and tools. Theory in implementing evidence-based findings into health care practice.

PubMed

Sales, Anne; Smith, Jeffrey; Curran, Geoffrey; Kochevar, Laura

2006-02-01

This paper presents a case for careful consideration of theory in planning to implement evidence-based practices into clinical care. As described, theory should be tightly linked to strategic planning through careful choice or creation of an implementation framework. Strategies should be linked to specific interventions and/or intervention components to be implemented, and the choice of tools should match the interventions and overall strategy, linking back to the original theory and framework. The thesis advanced is that in most studies where there is an attempt to implement planned change in clinical processes, theory is used loosely. An example of linking theory to intervention design is presented from a Mental Health Quality Enhancement Research Initiative effort to increase appropriate use of antipsychotic medication among patients with schizophrenia in the Veterans Health Administration.

The role of parental alcohol-specific communication in early adolescents' alcohol use.

PubMed

Van Der Vorst, Haske; Burk, William J; Engels, Rutger C M E

2010-10-01

Many alcohol prevention programs advocate conversations about alcohol between parents and children because verbal communication is the most direct way for parents to express their thoughts, rules, and concerns about alcohol to their children, so called alcohol-specific communication. Nevertheless, research on the effects of alcohol-specific communication has produced inconsistent findings. This study examined the bidirectional links between frequency of alcohol-specific communication and early adolescents' alcohol use, and the moderating effects on these links of gender and experience with alcohol. The longitudinal sample consisted of 428 Dutch early adolescents who were followed over 3 years. Results of structural equation models indicated that more frequent alcohol-specific communication at time two predicted more adolescent alcohol use at time three. Follow-up multiple-group analyses clearly show that prospective links between alcohol-specific communication and adolescent alcohol use were limited to adolescent males reporting the highest levels of drinking. For this group of drinking males, alcohol use predicted less parent-child communication, and more frequency of alcohol-specific communication predicted an increase in drinking. Alcohol-specific communication and adolescent alcohol use were not prospectively linked for males reporting lower levels of alcohol use or for adolescent females. These findings highlight the need for future research that examines both quantitative and qualitative aspects of how parents communicate with their adolescent children about alcohol. Advocation of specific parent-child communication skills meant to reduce youth alcohol use may be somewhat premature until additional studies refine our understanding of how specific parenting strategies are linked to different patterns of adolescent alcohol use. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

Using Multicountry Ecological and Observational Studies to Determine Dietary Risk Factors for Alzheimer's Disease.

PubMed

Grant, William B

2016-07-01

Rates of Alzheimer's disease (AD) are rising worldwide. The most important risk factors seem to be linked to diet. For example, when Japan made the nutrition transition from the traditional Japanese diet to the Western diet, AD rates rose from 1% in 1985 to 7% in 2008. Foods protective against AD include fruits, vegetables, grains, low-fat dairy products, legumes, and fish, whereas risk factors include meat, sweets, and high-fat dairy products. The evidence comes from ecological and observational studies as well as investigations of the mechanisms whereby dietary factors affect risk. The mechanisms linking dietary risk factors to AD are fairly well known and include increased oxidative stress from metal ions such as copper as well as from advanced glycation end products associated with high-temperature cooking, increased homocysteine concentrations, and cholesterol and its effects on amyloid beta, insulin resistance, and obesity. Lower 25-hydroxyvitamin D concentrations also are associated with increased risk of AD. In addition to reviewing the journal literature, a new ecological study was conducted using AD prevalence from 10 countries (Brazil, Chile, Cuba, Egypt, India, Mongolia, Nigeria, Republic of Korea, Sri Lanka, and the United States) along with dietary supply data 5, 10, and 15 years before the prevalence data. Dietary supply of meat or animal products less milk 5 years before AD prevalence had the highest correlations with AD prevalence in this study. Thus, reducing meat consumption could significantly reduce the risk of AD as well as of several cancers, diabetes mellitus type 2, stroke, and, likely, chronic kidney disease. • Single-country ecological data can be used to find links between diet and AD because the national diet changes, such as during the nutrition transition to a Western diet. • Multicountry ecological studies can be used to find links between dietary factors and risk of AD. • Prospective observational studies are useful in linking dietary components and patterns to risk of AD. • The most important dietary link to AD appears to be meat consumption, with eggs and high-fat dairy also contributing. • Diets high in grains, fruits, vegetables, and fish are associated with reduced risk of AD, but these factors cannot counter the effects of meat, eggs, and high-fat dairy. • Higher vitamin D status is associated with reduced risk of AD.

Integrated system links cost data, patient satisfaction scores for the first time.

PubMed

1999-10-01

Linking cost data, patient satisfaction scores. HBS International and The Picker Institute have joined forces to make integrated data available that directly links operational efficiency and patient satisfaction. Find out how the systems lets providers know when reducing expenses compromises care.

Ethnic Variations of Pathways Linking Socioeconomic Status, Parenting, and Preacademic Skills in a Nationally Representative Sample

ERIC Educational Resources Information Center

Iruka, Iheoma U.; Dotterer, Aryn M.; Pungello, Elizabeth P.

2014-01-01

Research Findings: Grounded in the investment model and informed by the integrative theory of the study of minority children, this study used the Early Childhood Longitudinal Study-Birth Cohort data set, a nationally representative sample of young children, to investigate whether the association between socioeconomic status (family income and…

Leptin - a link between obesity and osteoarthritis. applications for prevention and treatment.

PubMed

Vuolteenaho, Katriina; Koskinen, Anna; Moilanen, Eeva

2014-01-01

Osteoarthritis (OA) is the most common cause of musculoskeletal disability and pain in the world. The current drug treatment for OA is symptom relieving, and there is an urgent need for treatments that could retard, prevent or repair cartilage destruction in OA. Obesity is a major risk factor for OA. Traditionally, it has been thought to contribute to the development of OA by increasing the load on weight-bearing joints. However, this appears to be an over-simplification, because obesity is also linked to OA in the hand and finger joints. Recent studies have shown that adipocytokine leptin is a possible link between obesity and OA: Leptin levels in synovial fluid are increased in obese patients, leptin receptor (Ob-R) is expressed in cartilage, and leptin induces the production of matrix metalloproteinases (MMPs), pro-inflammatory mediators and nitric oxide (NO) in chondrocytes. Furthermore, according to the very recent findings, not only leptin levels in the joint but also leptin sensitivity in the cartilage are enhanced in obese OA patients. The findings supporting leptin as a causative link between obesity and OA offer leptin as a potential target to the development of disease-modifying drugs for osteoarthritis (DMOAD), especially for obese patients. © 2013 Nordic Pharmacological Society. Published by John Wiley & Sons Ltd.

Supporting Police Community Support Officers to Become Effective School Link Officers: Key Stakeholder Perceptions of a Pilot Professional Development Programme

ERIC Educational Resources Information Center

Thomas, Lorraine; Trotman, Dave

2017-01-01

This article presents the findings of a pilot professional development programme designed to support police community support officers (PCSOs) to become effective school link officers (SLOs) within urban secondary schools in the English West Midlands. Findings are presented via perceptions of key stakeholders: SLOs themselves; school-based mentors…

Sex-linked genomic variation and its relationship to avian plumage dichromatism and sexual selection.

PubMed

Huang, Huateng; Rabosky, Daniel L

2015-09-16

Sexual dichromatism is the tendency for sexes to differ in color pattern and represents a striking form of within-species morphological variation. Conspicuous intersexual differences in avian plumage are generally thought to result from Darwinian sexual selection, to the extent that dichromatism is often treated as a surrogate for the intensity of sexual selection in phylogenetic comparative studies. Intense sexual selection is predicted to leave a footprint on genetic evolution by reducing the relative genetic diversity on sex chromosome to that on the autosomes. In this study, we test the association between plumage dichromatism and sex-linked genetic diversity using eight species pairs with contrasting levels of dichromatism. We estimated Z-linked and autosomal genetic diversity for these non-model avian species using restriction-site associated (RAD) loci that covered ~3 % of the genome. We find that monochromatic birds consistently have reduced sex-linked genomic variation relative to phylogenetically-paired dichromatic species and this pattern is robust to mutational biases. Our results are consistent with several interpretations. If present-day sexual selection is stronger in dichromatic birds, our results suggest that its impact on sex-linked genomic variation is offset by other processes that lead to proportionately lower Z-linked variation in monochromatic species. We discuss possible factors that may contribute to this discrepancy between phenotypes and genomic variation. Conversely, it is possible that present-day sexual selection -- as measured by the variance in male reproductive success -- is stronger in the set of monochromatic taxa we have examined, potentially reflecting the importance of song, behavior and other non-plumage associated traits as targets of sexual selection. This counterintuitive finding suggests that the relationship between genomic variation and sexual selection is complex and highlights the need for a more comprehensive survey of genomic variation in avian taxa that vary markedly in social and genetic mating systems.

Exact and Optimal Quantum Mechanics/Molecular Mechanics Boundaries.

PubMed

Sun, Qiming; Chan, Garnet Kin-Lic

2014-09-09

Motivated by recent work in density matrix embedding theory, we define exact link orbitals that capture all quantum mechanical (QM) effects across arbitrary quantum mechanics/molecular mechanics (QM/MM) boundaries. Exact link orbitals are rigorously defined from the full QM solution, and their number is equal to the number of orbitals in the primary QM region. Truncating the exact set yields a smaller set of link orbitals optimal with respect to reproducing the primary region density matrix. We use the optimal link orbitals to obtain insight into the limits of QM/MM boundary treatments. We further analyze the popular general hybrid orbital (GHO) QM/MM boundary across a test suite of molecules. We find that GHOs are often good proxies for the most important optimal link orbital, although there is little detailed correlation between the detailed GHO composition and optimal link orbital valence weights. The optimal theory shows that anions and cations cannot be described by a single link orbital. However, expanding to include the second most important optimal link orbital in the boundary recovers an accurate description. The second optimal link orbital takes the chemically intuitive form of a donor or acceptor orbital for charge redistribution, suggesting that optimal link orbitals can be used as interpretative tools for electron transfer. We further find that two optimal link orbitals are also sufficient for boundaries that cut across double bonds. Finally, we suggest how to construct "approximately" optimal link orbitals for practical QM/MM calculations.

Sex, Drugs and STDs: Preliminary Findings from the Belfast Youth Development Study

ERIC Educational Resources Information Center

McAloney, Kareena; McCrystal, Patrick; Percy, Andrew

2010-01-01

Young people's participation in sexual risk behaviours is commonly linked with participation in a range of other risky behaviours, and in particular with substance use behaviours. This cross-sectional analysis of the sixth sweep of the Belfast Youth Development Study aimed to examine associations between substance use and sexual activity and…

Music and Suicidality: A Quantitative Review and Extension

ERIC Educational Resources Information Center

Stack, Steven; Lester, David; Rosenberg, Jonathan S.

2012-01-01

This article provides the first quantitative review of the literature on music and suicidality. Multivariate logistic regression techniques are applied to 90 findings from 21 studies. Investigations employing ecological data on suicide completions are 19.2 times more apt than other studies to report a link between music and suicide. More recent…

Organizational Climate, Services, and Outcomes in Child Welfare Systems

ERIC Educational Resources Information Center

Glisson, Charles; Green, Philip

2011-01-01

Objective: This study examines the association of organizational climate, casework services, and youth outcomes in child welfare systems. Building on preliminary findings linking organizational climate to youth outcomes over a 3-year follow-up period, the current study extends the follow-up period to 7 years and tests main, moderating and…

College Education and Attitudes toward Democracy in China: An Empirical Study

ERIC Educational Resources Information Center

Wang, Gang; Wu, Liyun; Han, Rongbin

2015-01-01

The modernization theory contends that there is a link between education and democracy. Yet few empirical studies have been done to investigate the role of higher education on promoting democratic values in the Chinese context. Using China General Social Survey 2006, this paper generates several findings which are not completely consistent with…

Supporting the Development of Risk-Taking Behaviours in the Early Years: An Exploratory Study

ERIC Educational Resources Information Center

Waters, Jane; Begley, Sharon

2007-01-01

Children's opportunities for independent play in natural outdoor spaces, and the associated opportunities to take and negotiate risk, are being eroded despite potential links between such play and the development of positive learning dispositions. This paper reports the findings of an exploratory study that documented the risk-taking behaviours…

Collegiate Diversity Experiences and Students' Views Regarding Social and Political Involvement

ERIC Educational Resources Information Center

Parker, Eugene T., III; Trolian, Teniell L.

2015-01-01

Using data from the Wabash National Study of Liberal Arts Education, this study examines the relationship between engagement in diversity experiences during college and student attitudes about the importance of being socially and politically involved at the end of their fourth year of college. Findings suggest a positive link between…

Media and Attention, Cognition, and School Achievement

ERIC Educational Resources Information Center

Schmidt, Marie Evans; Vandewater, Elizabeth A.

2008-01-01

Marie Evans Schmidt and Elizabeth Vandewater review research on links between various types of electronic media and the cognitive skills of school-aged children and adolescents. One central finding of studies to date, they say, is that the content delivered by electronic media is far more influential than the media themselves. Most studies, they…

Leadership for Effective Teacher Training Transfer in Kuwaiti Secondary Schools

ERIC Educational Resources Information Center

Winokur, Ilene K.; Sperandio, Jill

2017-01-01

This article reports on the findings of a study undertaken to examine the links between leadership practices of a transformational nature and the transfer of teacher training in the public high schools in Kuwait. The participants in the study were teachers who had undergone mandated professional development (PD) aimed at improving teaching…

Learning to Link Research, Practice, and Disciplinary Literacies: An Interview with Darin Stockdill

ERIC Educational Resources Information Center

Stockdill, Darin; Moore, David W.

2011-01-01

Darin Stockdill was a secondary school English and social studies teacher in Detroit. His early research with classroom instruction and professional development motivated him to begin doctoral study to explore how schools serving as research sites can become sites for professional development and collaboration. He finds an epistemic perspective on…

Answering the Call for Accountability: An Activity and Cost Analysis Case Study

ERIC Educational Resources Information Center

Carducci, Rozana; Kisker, Carrie B.; Chang, June; Schirmer, James

2007-01-01

This article summarizes the findings of a case study on the creation and application of an activity-based cost accounting model that links community college salary expenditures to mission-critical practices within academic divisions of a southern California community college. Although initially applied as a financial management tool in private…

Kiss High Blood Pressure Goodbye: The Relationship between Dark Chocolate and Hypertension

ERIC Educational Resources Information Center

Nordmoe, Eric D.

2008-01-01

This article reports on a delicious finding from a recent study claiming a causal link between dark chocolate consumption and blood pressure reductions. In the article, I provide ideas for using this study to whet student appetites for a discussion of statistical ideas, including experimental design, measurement error and inference methods.

Ending on a positive: Examining the role of safety leadership decisions, behaviours and actions in a safety critical situation.

PubMed

Donovan, Sarah-Louise; Salmon, Paul M; Horberry, Timothy; Lenné, Michael G

2018-01-01

Safety leadership is an important factor in supporting safe performance in the workplace. The present case study examined the role of safety leadership during the Bingham Canyon Mine high-wall failure, a significant mining incident in which no fatalities or injuries were incurred. The Critical Decision Method (CDM) was used in conjunction with a self-reporting approach to examine safety leadership in terms of decisions, behaviours and actions that contributed to the incidents' safe outcome. Mapping the analysis onto Rasmussen's Risk Management Framework (Rasmussen, 1997), the findings demonstrate clear links between safety leadership decisions, and emergent behaviours and actions across the work system. Communication and engagement based decisions featured most prominently, and were linked to different leadership practices across the work system. Further, a core sub-set of CDM decision elements were linked to the open flow and exchange of information across the work system, which was critical to supporting the safe outcome. The findings provide practical implications for the development of safety leadership capability to support safety within the mining industry. Copyright © 2017 Elsevier Ltd. All rights reserved.

A shared neural ensemble links distinct contextual memories encoded close in time

NASA Astrophysics Data System (ADS)

Cai, Denise J.; Aharoni, Daniel; Shuman, Tristan; Shobe, Justin; Biane, Jeremy; Song, Weilin; Wei, Brandon; Veshkini, Michael; La-Vu, Mimi; Lou, Jerry; Flores, Sergio E.; Kim, Isaac; Sano, Yoshitake; Zhou, Miou; Baumgaertel, Karsten; Lavi, Ayal; Kamata, Masakazu; Tuszynski, Mark; Mayford, Mark; Golshani, Peyman; Silva, Alcino J.

2016-06-01

Recent studies suggest that a shared neural ensemble may link distinct memories encoded close in time. According to the memory allocation hypothesis, learning triggers a temporary increase in neuronal excitability that biases the representation of a subsequent memory to the neuronal ensemble encoding the first memory, such that recall of one memory increases the likelihood of recalling the other memory. Here we show in mice that the overlap between the hippocampal CA1 ensembles activated by two distinct contexts acquired within a day is higher than when they are separated by a week. Several findings indicate that this overlap of neuronal ensembles links two contextual memories. First, fear paired with one context is transferred to a neutral context when the two contexts are acquired within a day but not across a week. Second, the first memory strengthens the second memory within a day but not across a week. Older mice, known to have lower CA1 excitability, do not show the overlap between ensembles, the transfer of fear between contexts, or the strengthening of the second memory. Finally, in aged mice, increasing cellular excitability and activating a common ensemble of CA1 neurons during two distinct context exposures rescued the deficit in linking memories. Taken together, these findings demonstrate that contextual memories encoded close in time are linked by directing storage into overlapping ensembles. Alteration of these processes by ageing could affect the temporal structure of memories, thus impairing efficient recall of related information.

Faster-X evolution: Theory and evidence from Drosophila.

PubMed

Charlesworth, Brian; Campos, José L; Jackson, Benjamin C

2018-02-12

A faster rate of adaptive evolution of X-linked genes compared with autosomal genes can be caused by the fixation of recessive or partially recessive advantageous mutations, due to the full expression of X-linked mutations in hemizygous males. Other processes, including recombination rate and mutation rate differences between X chromosomes and autosomes, may also cause faster evolution of X-linked genes. We review population genetics theory concerning the expected relative values of variability and rates of evolution of X-linked and autosomal DNA sequences. The theoretical predictions are compared with data from population genomic studies of several species of Drosophila. We conclude that there is evidence for adaptive faster-X evolution of several classes of functionally significant nucleotides. We also find evidence for potential differences in mutation rates between X-linked and autosomal genes, due to differences in mutational bias towards GC to AT mutations. Many aspects of the data are consistent with the male hemizygosity model, although not all possible confounding factors can be excluded. © 2018 John Wiley & Sons Ltd.

Scientists find link between allergic and autoimmune diseases in mouse study

Cancer.gov

Scientists at the National Institutes of Health, and their colleagues, have discovered that a gene called BACH2 may play a central role in the development of diverse allergic and autoimmune diseases, such as multiple sclerosis, asthma, Crohn's disease, ce

Connecting with Industry: Bridging the Divide

ERIC Educational Resources Information Center

Berman, Judith

2008-01-01

The shifting funding climate in Australian higher education encourages universities to enter into research partnerships with industry. Yet, studies of industries' experiences of their research links with universities are rare. Consequently, research managers often find themselves attempting to promote and facilitate industry engagement with…

The role of the media in body image concerns among women: a meta-analysis of experimental and correlational studies.

PubMed

Grabe, Shelly; Ward, L Monique; Hyde, Janet Shibley

2008-05-01

Research suggests that exposure to mass media depicting the thin-ideal body may be linked to body image disturbance in women. This meta-analysis examined experimental and correlational studies testing the links between media exposure to women's body dissatisfaction, internalization of the thin ideal, and eating behaviors and beliefs with a sample of 77 studies that yielded 141 effect sizes. The mean effect sizes were small to moderate (ds = -.28, -.39, and -.30, respectively). Effects for some outcome variables were moderated by publication year and study design. The findings support the notion that exposure to media images depicting the thin-ideal body is related to body image concerns for women. (Copyright) 2008 APA, all rights reserved.

Why Do You Believe in God? Relationships between Religious Belief, Analytic Thinking, Mentalizing and Moral Concern

PubMed Central

Jack, Anthony Ian; Friedman, Jared Parker; Boyatzis, Richard Eleftherios; Taylor, Scott Nolan

2016-01-01

Prior work has established that analytic thinking is associated with disbelief in God, whereas religious and spiritual beliefs have been positively linked to social and emotional cognition. However, social and emotional cognition can be subdivided into a number of distinct dimensions, and some work suggests that analytic thinking is in tension with some aspects of social-emotional cognition. This leaves open two questions. First, is belief linked to social and emotional cognition in general, or a specific dimension in particular? Second, does the negative relationship between belief and analytic thinking still hold after relationships with social and emotional cognition are taken into account? We report eight hypothesis-driven studies which examine these questions. These studies are guided by a theoretical model which focuses on the distinct social and emotional processing deficits associated with autism spectrum disorders (mentalizing) and psychopathy (moral concern). To our knowledge no other study has investigated both of these dimensions of social and emotion cognition alongside analytic thinking. We find that religious belief is robustly positively associated with moral concern (4 measures), and that at least part of the negative association between belief and analytic thinking (2 measures) can be explained by a negative correlation between moral concern and analytic thinking. Using nine different measures of mentalizing, we found no evidence of a relationship between mentalizing and religious or spiritual belief. These findings challenge the theoretical view that religious and spiritual beliefs are linked to the perception of agency, and suggest that gender differences in religious belief can be explained by differences in moral concern. These findings are consistent with the opposing domains hypothesis, according to which brain areas associated with moral concern and analytic thinking are in tension. PMID:27008093

Why Do You Believe in God? Relationships between Religious Belief, Analytic Thinking, Mentalizing and Moral Concern.

PubMed

Jack, Anthony Ian; Friedman, Jared Parker; Boyatzis, Richard Eleftherios; Taylor, Scott Nolan

2016-01-01

Prior work has established that analytic thinking is associated with disbelief in God, whereas religious and spiritual beliefs have been positively linked to social and emotional cognition. However, social and emotional cognition can be subdivided into a number of distinct dimensions, and some work suggests that analytic thinking is in tension with some aspects of social-emotional cognition. This leaves open two questions. First, is belief linked to social and emotional cognition in general, or a specific dimension in particular? Second, does the negative relationship between belief and analytic thinking still hold after relationships with social and emotional cognition are taken into account? We report eight hypothesis-driven studies which examine these questions. These studies are guided by a theoretical model which focuses on the distinct social and emotional processing deficits associated with autism spectrum disorders (mentalizing) and psychopathy (moral concern). To our knowledge no other study has investigated both of these dimensions of social and emotion cognition alongside analytic thinking. We find that religious belief is robustly positively associated with moral concern (4 measures), and that at least part of the negative association between belief and analytic thinking (2 measures) can be explained by a negative correlation between moral concern and analytic thinking. Using nine different measures of mentalizing, we found no evidence of a relationship between mentalizing and religious or spiritual belief. These findings challenge the theoretical view that religious and spiritual beliefs are linked to the perception of agency, and suggest that gender differences in religious belief can be explained by differences in moral concern. These findings are consistent with the opposing domains hypothesis, according to which brain areas associated with moral concern and analytic thinking are in tension.

Experience is Instrumental in Tuning a Link Between Language and Cognition: Evidence from 6- to 7- Month-Old Infants' Object Categorization.

PubMed

Perszyk, Danielle R; Waxman, Sandra R

2017-04-19

At birth, infants not only prefer listening to human vocalizations, but also have begun to link these vocalizations to cognition: For infants as young as three months of age, listening to human language supports object categorization, a core cognitive capacity. This precocious link is initially broad: At 3 and 4 months, vocalizations of both humans and nonhuman primates support categorization. But by 6 months, infants have narrowed the link: Only human vocalizations support object categorization. Here we ask what guides infants as they tune their initially broad link to a more precise one, engaged only by the vocalizations of our species. Across three studies, we use a novel exposure paradigm to examine the effects of experience. We document that merely exposing infants to nonhuman primate vocalizations enables infants to preserve the early-established link between this signal and categorization. In contrast, exposing infants to backward speech - a signal that fails to support categorization at any age - offers no such advantage. Our findings reveal the power of early experience as infants specify which signals, from an initially broad set, they will continue to link to cognition.

The Structure and Evolution of Buyer-Supplier Networks

PubMed Central

Mizuno, Takayuki; Souma, Wataru; Watanabe, Tsutomu

2014-01-01

In this paper, we investigate the structure and evolution of customer-supplier networks in Japan using a unique dataset that contains information on customer and supplier linkages for more than 500,000 incorporated non-financial firms for the five years from 2008 to 2012. We find, first, that the number of customer links is unequal across firms; the customer link distribution has a power-law tail with an exponent of unity (i.e., it follows Zipf's law). We interpret this as implying that competition among firms to acquire new customers yields winners with a large number of customers, as well as losers with fewer customers. We also show that the shortest path length for any pair of firms is, on average, 4.3 links. Second, we find that link switching is relatively rare. Our estimates indicate that the survival rate per year for customer links is 92 percent and for supplier links 93 percent. Third and finally, we find that firm growth rates tend to be more highly correlated the closer two firms are to each other in a customer-supplier network (i.e., the smaller is the shortest path length for the two firms). This suggests that a non-negligible portion of fluctuations in firm growth stems from the propagation of microeconomic shocks – shocks affecting only a particular firm – through customer-supplier chains. PMID:25000368

The structure and evolution of buyer-supplier networks.

PubMed

Mizuno, Takayuki; Souma, Wataru; Watanabe, Tsutomu

2014-01-01

In this paper, we investigate the structure and evolution of customer-supplier networks in Japan using a unique dataset that contains information on customer and supplier linkages for more than 500,000 incorporated non-financial firms for the five years from 2008 to 2012. We find, first, that the number of customer links is unequal across firms; the customer link distribution has a power-law tail with an exponent of unity (i.e., it follows Zipf's law). We interpret this as implying that competition among firms to acquire new customers yields winners with a large number of customers, as well as losers with fewer customers. We also show that the shortest path length for any pair of firms is, on average, 4.3 links. Second, we find that link switching is relatively rare. Our estimates indicate that the survival rate per year for customer links is 92 percent and for supplier links 93 percent. Third and finally, we find that firm growth rates tend to be more highly correlated the closer two firms are to each other in a customer-supplier network (i.e., the smaller is the shortest path length for the two firms). This suggests that a non-negligible portion of fluctuations in firm growth stems from the propagation of microeconomic shocks - shocks affecting only a particular firm - through customer-supplier chains.

CCP interoperability and system stability

NASA Astrophysics Data System (ADS)

Feng, Xiaobing; Hu, Haibo

2016-09-01

To control counterparty risk, financial regulations such as the Dodd-Frank Act are increasingly requiring standardized derivatives trades to be cleared by central counterparties (CCPs). It is anticipated that in the near term future, CCPs across the world will be linked through interoperability agreements that facilitate risk sharing but also serve as a conduit for transmitting shocks. This paper theoretically studies a networked network with CCPs that are linked through interoperability arrangements. The major finding is that the different configurations of networked network CCPs contribute to the different properties of the cascading failures.

Realization of the Najafi-Golestanian microswimmer

NASA Astrophysics Data System (ADS)

Grosjean, Galien; Hubert, Maxime; Lagubeau, Guillaume; Vandewalle, Nicolas

2016-08-01

A paradigmatic microswimmer is the three-linked-spheres model, which follows a minimalist approach for propulsion by shape shifting. As such, it has been the subject of numerous analytical and numerical studies. In this Rapid Communication, an experimental three-linked-spheres swimmer is created by self-assembling ferromagnetic particles at an air-water interface. It is powered by a uniform oscillating magnetic field. A model, using two harmonic oscillators, reproduces the experimental findings. Because the model remains general, the same approach could be used to design a variety of efficient microswimmers.

Literature Links: Thematic Units Linking Read-Alouds and Computer Activities

ERIC Educational Resources Information Center

Labbo, Linda D.; Love, Mary Susan; Park Prior, Miri; Hubbard, Betty P.; Ryan, Tammy

2006-01-01

This book gives the reader ideas for providing primary-grade students with literacy learning opportunities that integrate conventional literacies, such as phonics and comprehension, with new literacies, such as multimedia composition and hyperlink navigation. The reader will find a variety of linked activities, including reading children's books,…

Fix Broken and Redirected Links Using Group Dashboard Link Report

EPA Pesticide Factsheets

Learn how to use the tools provided by Drupal in the Group Dashboard to find and correct links on your site that are broken (404 and 403 error codes), or that redirect (301 and 302), for example to a homepage rather than the originally intended content.

Epidermal growth factor receptor and integrins control force-dependent vinculin recruitment to E-cadherin junctions.

PubMed

Sehgal, Poonam; Kong, Xinyu; Wu, Jun; Sunyer, Raimon; Trepat, Xavier; Leckband, Deborah

2018-03-20

This study reports novel findings that link E-cadherin (also known as CDH1)-mediated force-transduction signaling to vinculin targeting to intercellular junctions via epidermal growth factor receptor (EGFR) and integrins. These results build on previous findings that demonstrated that mechanically perturbed E-cadherin receptors activate phosphoinositide 3-kinase and downstream integrins in an EGFR-dependent manner. Results of this study show that this EGFR-mediated kinase cascade controls the force-dependent recruitment of vinculin to stressed E-cadherin complexes - a key early signature of cadherin-based mechanotransduction. Vinculin targeting requires its phosphorylation at tyrosine 822 by Abl family kinases (hereafter Abl), but the origin of force-dependent Abl activation had not been identified. We now present evidence that integrin activation, which is downstream of EGFR signaling, controls Abl activation, thus linking E-cadherin to Abl through a mechanosensitive signaling network. These findings place EGFR and integrins at the center of a positive-feedback loop, through which force-activated E-cadherin signals regulate vinculin recruitment to cadherin complexes in response to increased intercellular tension.This article has an associated First Person interview with the first author of the paper. © 2018. Published by The Company of Biologists Ltd.

Resilience in mental health: linking psychological and neurobiological perspectives

PubMed Central

Rutten, B P F; Hammels, C; Geschwind, N; Menne-Lothmann, C; Pishva, E; Schruers, K; van den Hove, D; Kenis, G; van Os, J; Wichers, M

2013-01-01

Objective To review the literature on psychological and biological findings on resilience (i.e. the successful adaptation and swift recovery after experiencing life adversities) at the level of the individual, and to integrate findings from animal and human studies. Method Electronic and manual literature search of MEDLINE, EMBASE and PSYCHINFO, using a range of search terms around biological and psychological factors influencing resilience as observed in human and experimental animal studies, complemented by review articles and cross-references. Results The term resilience is used in the literature for different phenomena ranging from prevention of mental health disturbance to successful adaptation and swift recovery after experiencing life adversities, and may also include post-traumatic psychological growth. Secure attachment, experiencing positive emotions and having a purpose in life are three important psychological building blocks of resilience. Overlap between psychological and biological findings on resilience in the literature is most apparent for the topic of stress sensitivity, although recent results suggest a crucial role for reward experience in resilience. Conclusion Improving the understanding of the links between genetic endowment, environmental impact and gene–environment interactions with developmental psychology and biology is crucial for elucidating the neurobiological and psychological underpinnings of resilience. PMID:23488807

Enabling Linked Science in Global Climate Uncertainty Quantification (UQ) Research

NASA Astrophysics Data System (ADS)

Elsethagen, T.; Stephan, E.; Lin, G.; Williams, D.; Banks, E.

2012-12-01

This paper shares a real-world global climate UQ science use case and illustrates how a linked science application called Provenance Environment (ProvEn), currently being developed, enables and facilitates scientific teams to publish, share, link, and discover new links over their UQ research results. UQ results include terascale datasets that are published to an Earth Systems Grid Federation (ESGF) repository. ProvEn demonstrates how a scientific team conducting UQ studies can discover dataset links using its domain knowledgebase, allowing them to better understand the UQ study research objectives, the experimental protocol used, the resulting dataset lineage, related analytical findings, ancillary literature citations, along with the social network of scientists associated with the study. This research claims that scientists using this linked science approach will not only allow them to greatly benefit from understanding a particular dataset within a knowledge context, a benefit can also be seen by the cross reference of knowledge among the numerous UQ studies being stored in ESGF. ProvEn collects native forms of data provenance resources as the UQ study is carried out. The native data provenance resources can be collected from a variety of sources such as scripts, a workflow engine log, simulation log files, scientific team members etc. Schema alignment is used to translate the native forms of provenance into a set of W3C PROV-O semantic statements used as a common interchange format which will also contain URI references back to resources in the UQ study dataset for querying and cross referencing. ProvEn leverages Fedora Commons' digital object model in a Resource Oriented Architecture (ROA) (i.e. a RESTful framework) to logically organize and partition native and translated provenance resources by UQ study. The ROA also provides scientists the means to both search native and translated forms of provenance.

Exposure to Community Violence and Sexual Behaviors Among African American Youth: Testing Multiple Pathways.

PubMed

Voisin, Dexter R; Hotton, Anna; Neilands, Torsten

2018-01-01

African American youth bear a disproportionate burden of sexually transmitted infections. A growing number of studies document that youth exposure to community violence and sexual behaviors are highly correlated. Despite such growing evidence, only a few studies have empirically tested conceptually driven pathways that may account for such relationships. This study seeks to address that gap by exploring multiple pathways linking exposure to community violence and youth sexual behaviors. Using an existing sample of 563 African American youth attending high school, we examined whether possible links between exposure to community violence and sexual activity, sexual risk behaviors were mediated by aggression, low student-teacher connectedness, and negative peer norms. Major findings indicated indirect relationships between exposures to community violence and both sexual activity and risky sex, mediated by aggression and negative peer norms with no significant differences based on gender or socioeconomic status. Overall findings also indicated a significant indirect effect of aggression to risky sex via negative peer norms and from community violence to risky peer norms via aggression. By illuminating ways that community violence, aggression, peer norms, and sexual behaviors are dynamically interrelated, these findings have significant implications for future research and intervention initiatives aimed at addressing the different pathways.

Oligoclonal bands in multiple sclerosis reactive against two herpesviruses and association with magnetic resonance imaging findings

PubMed Central

Virtanen, JO; Wohler, J; Fenton, K; Reich, DS; Jacobson, S

2016-01-01

Background Two human herpesviruses, human herpesvirus 6 (HHV-6), and Epstein-Barr virus (EBV), have been repeatedly linked to multiple sclerosis (MS). Objective The aim of this study was to investigate HHV-6 and EBV reactive oligoclonal bands (OCBs), and viral DNA in the intrathecal compartment in MS. Methods The reactivity of OCBs in cerebrospinal fluid (CSF) for EBV and HHV-6 antigens and stability of virus reactive OCBs over time were studied in a well-characterized MS patient cohort. Associations between virus reactive OCBs and viral DNA in CSF (and any clinical and/or radiological findings) were investigated. Results Of patients with MS, 38% had OCBs reactive to either one of the viruses studied, compared to none in the patients with other inflammatory neurological diseases (p=0.005). The banding pattern of virus reactive OCBs remained the same over time. Furthermore, MS patients with viral DNA in CSF had more contrast enhancing lesions (CELs). Conclusion The stable presence of herpesvirus reactive OCBs in CSF further strengthens the association of MS with these viruses. The finding that herpesviruses might be linked to the appearance of active lesions warrants investigation of new therapeutic strategies to treat these viruses in MS. PMID:23722324

A PKC-MARCKS-PI3K regulatory module links Ca2+ and PIP3 signals at the leading edge of polarized macrophages.

PubMed

Ziemba, Brian P; Falke, Joseph J

2018-01-01

The leukocyte chemosensory pathway detects attractant gradients and directs cell migration to sites of inflammation, infection, tissue damage, and carcinogenesis. Previous studies have revealed that local Ca2+ and PIP3 signals at the leading edge of polarized leukocytes play central roles in positive feedback loop essential to cell polarization and chemotaxis. These prior studies showed that stimulation of the leading edge Ca2+ signal can strongly activate PI3K, thereby triggering a larger PIP3 signal, but did not elucidate the mechanistic link between Ca2+ and PIP3 signaling. A hypothesis explaining this link emerged, postulating that Ca2+-activated PKC displaces the MARCKS protein from plasma membrane PIP2, thereby releasing sequestered PIP2 to serve as the target and substrate lipid of PI3K in PIP3 production. In vitro single molecule studies of the reconstituted pathway on lipid bilayers demonstrated the feasibility of this PKC-MARCKS-PI3K regulatory module linking Ca2+ and PIP3 signals in the reconstituted system. The present study tests the model predictions in live macrophages by quantifying the effects of: (a) two pathway activators-PDGF and ATP that stimulate chemoreceptors and Ca2+ influx, respectively; and (b) three pathway inhibitors-wortmannin, EGTA, and Go6976 that inhibit PI3K, Ca2+ influx, and PKC, respectively; on (c) four leading edge activity sensors-AKT-PH-mRFP, CKAR, MARCKSp-mRFP, and leading edge area that report on PIP3 density, PKC activity, MARCKS membrane binding, and leading edge expansion/contraction, respectively. The results provide additional evidence that PKC and PI3K are both essential elements of the leading edge positive feedback loop, and strongly support the existence of a PKC-MARCKS-PI3K regulatory module linking the leading edge Ca2+ and PIP3 signals. As predicted, activators stimulate leading edge PKC activity, displacement of MARCKS from the leading edge membrane and increased leading edge PIP3 levels, while inhibitors trigger the opposite effects. Comparison of the findings for the ameboid chemotaxis of leukocytes with recently published findings for the mesenchymal chemotaxis of fibroblasts suggests that some features of the emerging leukocyte leading edge core pathway (PLC-DAG-Ca2+-PKC-MARCKS-PIP2-PI3K-PIP3) may well be shared by all chemotaxing eukaryotic cells, while other elements of the leukocyte pathway may be specialized features of these highly optimized, professional gradient-seeking cells. More broadly, the findings suggest a molecular mechanism for the strong links between phospho-MARCKS and many human cancers.

A PKC-MARCKS-PI3K regulatory module links Ca2+ and PIP3 signals at the leading edge of polarized macrophages

PubMed Central

Ziemba, Brian P.

2018-01-01

The leukocyte chemosensory pathway detects attractant gradients and directs cell migration to sites of inflammation, infection, tissue damage, and carcinogenesis. Previous studies have revealed that local Ca2+ and PIP3 signals at the leading edge of polarized leukocytes play central roles in positive feedback loop essential to cell polarization and chemotaxis. These prior studies showed that stimulation of the leading edge Ca2+ signal can strongly activate PI3K, thereby triggering a larger PIP3 signal, but did not elucidate the mechanistic link between Ca2+ and PIP3 signaling. A hypothesis explaining this link emerged, postulating that Ca2+-activated PKC displaces the MARCKS protein from plasma membrane PIP2, thereby releasing sequestered PIP2 to serve as the target and substrate lipid of PI3K in PIP3 production. In vitro single molecule studies of the reconstituted pathway on lipid bilayers demonstrated the feasibility of this PKC-MARCKS-PI3K regulatory module linking Ca2+ and PIP3 signals in the reconstituted system. The present study tests the model predictions in live macrophages by quantifying the effects of: (a) two pathway activators—PDGF and ATP that stimulate chemoreceptors and Ca2+ influx, respectively; and (b) three pathway inhibitors—wortmannin, EGTA, and Go6976 that inhibit PI3K, Ca2+ influx, and PKC, respectively; on (c) four leading edge activity sensors—AKT-PH-mRFP, CKAR, MARCKSp-mRFP, and leading edge area that report on PIP3 density, PKC activity, MARCKS membrane binding, and leading edge expansion/contraction, respectively. The results provide additional evidence that PKC and PI3K are both essential elements of the leading edge positive feedback loop, and strongly support the existence of a PKC-MARCKS-PI3K regulatory module linking the leading edge Ca2+ and PIP3 signals. As predicted, activators stimulate leading edge PKC activity, displacement of MARCKS from the leading edge membrane and increased leading edge PIP3 levels, while inhibitors trigger the opposite effects. Comparison of the findings for the ameboid chemotaxis of leukocytes with recently published findings for the mesenchymal chemotaxis of fibroblasts suggests that some features of the emerging leukocyte leading edge core pathway (PLC-DAG-Ca2+-PKC-MARCKS-PIP2-PI3K-PIP3) may well be shared by all chemotaxing eukaryotic cells, while other elements of the leukocyte pathway may be specialized features of these highly optimized, professional gradient-seeking cells. More broadly, the findings suggest a molecular mechanism for the strong links between phospho-MARCKS and many human cancers. PMID:29715315

Human face structure correlates with professional baseball performance: insights from professional Japanese baseball players.

PubMed

Tsujimura, Hikaru; Banissy, Michael J

2013-06-23

In our daily lives, we use faces as a major source of information about other people. Recent work has begun to highlight how one's facial width-to-height ratio (fWHR) is linked to a number of behaviours (e.g. deception, aggression and financial performance in firms). fWHR has also been linked to several factors that may be beneficial for sport (e.g. achievement drive, winning mentality and aggression). Despite this, few studies have examined the relationship between fWHR and sports performance, and these have focused on Caucasian sportsmen. Here, we investigated the relationship between fWHR and baseball performance in professional Japanese baseball players. We show that fWHR is positively related with home run performance across two consecutive seasons. The findings provide the first evidence linking fWHR to baseball performance and linking fWHR to behavioural outcomes in Asian participants.

Phase Diagram of the Bose Hubbard Model with Weak Links

NASA Astrophysics Data System (ADS)

Hettiarachchilage, Kalani; Rousseau, Valy; Tam, Ka-Ming; Moreno, Juana; Jarrell, Mark; Sheehy, Daniel

2012-02-01

We study the ground state phase diagram of strongly interacting ultracold Bose gas in a one-dimensional optical lattice with a tunable weak link, by means of Quantum Monte Carlo simulation. This model contains an on-site repulsive interaction (U) and two different near-neighbor hopping terms, J and t, for the weak link and the remainder of the chain, respectively. We show that by reducing the strength of J, a novel intermediate phase develops which is compressible and non-superfluid. This novel phase is identified as a Normal Bose Liquid (NBL) which does not appear in the phase diagram of the homogeneous bosonic Hubbard model. Further, we find a linear variation of the phase boundary of Normal Bose Liquid (NBL) to SuperFluid (SF) as a function of the strength of the weak link. These results may provide a new path to design advanced atomtronic devices in the future.

Influence of mother, father, and child risk on parenting and children's cognitive and social behaviors.

PubMed

Cabrera, Natasha J; Fagan, Jay; Wight, Vanessa; Schadler, Cornelia

2011-01-01

The association among mothers', fathers', and infants' risk and cognitive and social behaviors at 24 months was examined using structual equation modeling and data on 4,200 on toddlers and their parents from the Early Childhood Longitudinal Study, Birth Cohort. There were 3 main findings. First, for cognitive outcomes, maternal risk was directly and indirectly linked to it through maternal sensitivity whereas paternal risk was only indirectly related through maternal sensitivity. Second, for social behaviors, maternal and paternal risks were indirectly linked through maternal sensitivity and father engagement. Third, maternal and paternal levels of risk were linked to maternal supportiveness whereas mothers' and children's risk were linked to paternal cognitive stimulation. Implications are that policy makers must take into account effects of mothers', children's, and fathers' risk on young children's functioning. © 2011 The Authors. Child Development © 2011 Society for Research in Child Development, Inc.

Maternal emotional feeding practices and adolescent daughters' emotional eating: Mediating roles of avoidant and preoccupied coping.

PubMed

Goldstein, Miriam; Tan, Cin Cin; Chow, Chong Man

2017-09-01

The current study examined the link between early childhood emotional feeding and adolescent girls' emotional eating, using maladaptive coping styles as the underlying mechanisms mediating these associations. We examined adolescent girls' and mothers' retrospective reports of emotional feeding during childhood, as well as adolescent girls' current reports of their coping behaviors (i.e., preoccupied and avoidant) and emotional eating. Findings showed that adolescent girls' and mothers' retrospective reports of early emotional feeding were positively associated with adolescent girls' emotional eating. Preoccupied coping, but not avoidant coping, mediated the associations between early emotional feeding (reported by adolescents and mothers) and adolescents' current emotional eating. In conclusion, findings suggest that early childhood feeding experiences are linked to the development of maladaptive coping and emotional eating among adolescent girls. Copyright © 2017 Elsevier Ltd. All rights reserved.

A Collective Case Study of the Influence of Teachers' Beliefs and Knowledge on Error-Handling Practices during Class Discussion of Mathematics

ERIC Educational Resources Information Center

Bray, Wendy S.

2011-01-01

This collective case study examines the influence of 4 third-grade teachers' beliefs and knowledge on their error-handling practices during class discussion of mathematics. Study findings suggest that, although teachers' ways of handling student errors during class discussion of mathematics are clearly linked to both teacher beliefs and teacher…

Urban Seventh Grade Students: A Report of Health Risk Behaviors and Exposure to Violence

ERIC Educational Resources Information Center

Dowdell, Elizabeth Burgess

2012-01-01

The health of adolescents and the adults they will become can be linked to the health-related behaviors they adopt as children. To replicate a pilot study with a more culturally diverse population a descriptive, correlational study was undertaken with 379 seventh grade students. Key findings from this study include (a) students exposed or involved…

Organisation and Management of Continuing Higher Education: Findings of a Comparative Study in Six Countries from a German Perspective

ERIC Educational Resources Information Center

Knust, Michaela; Zawacki-Richter, Olaf; Hanft, Anke

2008-01-01

An international comparison study investigated the organisation and management of continuing higher education (CHE) in Germany, Finland, France, the United Kingdom, Austria and the United States of America. CHE is compared on the system level (boundaries between traditional study programmes and CHE, linking of CHE and vocational training,…

Association of Aggressive Behaviours with Psychiatric Disorders, Age, Sex and Degree of Intellectual Disability: A Large-Scale Survey

ERIC Educational Resources Information Center

Tsiouris, J. A.; Kim, S. Y.; Brown, W. T.; Cohen, I. L.

2011-01-01

Background: The link between aggression and mental disorders has been the focus of diverse studies in persons with and without intellectual disabilities (ID). Because of discrepancies in the finding of studies in persons with ID to date, and because of differences in research design, instruments used and the population studied, more research is…

Bias in the Flesh

PubMed Central

Messing, Solomon; Jabon, Maria; Plaut, Ethan

2016-01-01

There is strong evidence linking skin complexion to negative stereotypes and adverse real-world outcomes. We extend these findings to political ad campaigns, in which skin complexion can be easily manipulated in ways that are difficult to detect. Devising a method to measure how dark a candidate appears in an image, this paper examines how complexion varied with ad content during the 2008 presidential election campaign (study 1). Findings show that darker images were more frequent in negative ads—especially those linking Obama to crime—which aired more frequently as Election Day approached. We then conduct an experiment to document how these darker images can activate stereotypes, and show that a subtle darkness manipulation is sufficient to activate the most negative stereotypes about Blacks—even when the candidate is a famous counter-stereotypical exemplar—Barack Obama (study 2). Further evidence of an evaluative penalty for darker skin comes from an observational study measuring affective responses to depictions of Obama with varying skin complexion, presented via the Affect Misattribution Procedure in the 2008 American National Election Study (study 3). This study demonstrates that darker images are used in a way that complements ad content, and shows that doing so can negatively affect how individuals evaluate candidates and think about politics. PMID:27257306

Strategic Human Resource Development. Symposium.

ERIC Educational Resources Information Center

2002

This document contains three papers on strategic human resource (HR) development. "Strategic HR Orientation and Firm Performance in India" (Kuldeep Singh) reports findings from a study of Indian business executives that suggests there is a positive link between HR policies and practices and workforce motivation and loyalty and…

An Expert Teacher's Thinking and Teaching and Instructional Design Models and Principles: An Ethnographic Study.

ERIC Educational Resources Information Center

Moallem, Mahnaz

1998-01-01

Examines an expert teacher's thinking and teaching processes in order to link them to instructional-design procedures. Findings suggest that there were fundamental differences between the teacher's thinking and teaching processes and microinstructional design models. (Author/AEF)

Effect of carbon nanotube dispersion on glass transition in cross-linked epoxy-carbon nanotube nanocomposites: role of interfacial interactions.

PubMed

Khare, Ketan S; Khare, Rajesh

2013-06-20

We have used atomistic molecular simulations to study the effect of nanofiller dispersion on the glass transition behavior of cross-linked epoxy-carbon nanotube (CNT) nanocomposites. Specific chemical interactions at the interface of CNTs and cross-linked epoxy create an interphase region, whose impact on the properties of their nanocomposites increases with an increasing extent of dispersion. To investigate this aspect, we have compared the volumetric, structural, and dynamical properties of three systems: neat cross-linked epoxy, cross-linked epoxy nanocomposite containing dispersed CNTs, and cross-linked epoxy nanocomposite containing aggregated CNTs. We find that the nanocomposite containing dispersed CNTs shows a depression in the glass transition temperature (Tg) by ~66 K as compared to the neat cross-linked epoxy, whereas such a large depression is absent in the nanocomposite containing aggregated CNTs. Our results suggest that the poor interfacial interactions between the CNTs and the cross-linked epoxy matrix lead to a more compressible interphase region between the CNTs and the bulk matrix. An analysis of the resulting dynamic heterogeneity shows that the probability of percolation of immobile domains becomes unity near the Tg calculated from volumetric properties. Our observations also lend support to the conceptual analogy between polymer nanocomposites and the nanoconfinement of polymer thin films.

Dark Triad, Perceptions of Organizational Politics and Counterproductive Work Behaviors: The Moderating Effect of Political Skills

PubMed Central

Baloch, Muhammad A.; Meng, Fanchen; Xu, Zefeng; Cepeda-Carrion, Ignacio; Danish; Bari, Muhammad W.

2017-01-01

The aim of this work focuses on the relationship among the Dark Triad (psychopathy, narcissism, and Machiavellianism), perceptions of organizational politics, political skills, and counterproductive work behavior. This study empirically tests the mediating role of perceptions of organizational politics in the relationship between the Dark Triad and counterproductive work behavior. Furthermore, the study investigates the moderating role of political skills in strengthening the link between the Dark Triad and the perceptions of organizational politics. A sample of 149 participants was randomly selected. To analyze the data of the present work, we employed a structural equation model using partial least square and PROCESS. From empirical findings, we imply an inference that perception of organizational politics partially mediates the Dark Triad's influence on the counterproductive work behavior. Moreover, the results identify the moderating role of political skills in strengthening the link between the Dark Triad and the perceptions of organizational politics. Empirical findings suggest important policy implications for the hospitality industry. PMID:29167654

Schizotypal traits in a non-clinical sample from Hawai'i.

PubMed

Schiffman, Jason

2004-03-01

Most research investigating schizotypal traits, and linking schizotypal personality disorder (SPD) to later schizophrenia, has used Caucasian samples. The lack of cross-cultural comparisons on SPD trait scales inhibits confidence in generalizing the link between SPD and schizophrenia to non-Caucasian populations. The few studies investigating cross-cultural rates of schizotypal traits in non-clinical samples report mixed findings with respect to cultural variation. This study report rates of schizotypal traits in an ethnically and culturally diverse non-clinical sample (N = 353) in the state of Hawaii using the Schizotypai Personality Disorder Questionnaire-B (SPQ-B). Analyses did not detect significantly elevated rates between ethnic groups on the Cognitive/Perceptual, Disorganized, or Total SPQ Score Scales. Significant differences between Caucasians and Asians, as well as between Caucasians and Mixed Ethnicity on the SPQ-B Interpersonal Scale suggest relatively less shyness and more sociability in the Caucasian group. Generally, findings of no significant differences between ethnic groups on the SPQ-B suggest that rates of schizotypy are similar across ethnic groups in Hawaii.

Dark Triad, Perceptions of Organizational Politics and Counterproductive Work Behaviors: The Moderating Effect of Political Skills.

PubMed

Baloch, Muhammad A; Meng, Fanchen; Xu, Zefeng; Cepeda-Carrion, Ignacio; Danish; Bari, Muhammad W

2017-01-01

The aim of this work focuses on the relationship among the Dark Triad (psychopathy, narcissism, and Machiavellianism), perceptions of organizational politics, political skills, and counterproductive work behavior. This study empirically tests the mediating role of perceptions of organizational politics in the relationship between the Dark Triad and counterproductive work behavior. Furthermore, the study investigates the moderating role of political skills in strengthening the link between the Dark Triad and the perceptions of organizational politics. A sample of 149 participants was randomly selected. To analyze the data of the present work, we employed a structural equation model using partial least square and PROCESS. From empirical findings, we imply an inference that perception of organizational politics partially mediates the Dark Triad's influence on the counterproductive work behavior. Moreover, the results identify the moderating role of political skills in strengthening the link between the Dark Triad and the perceptions of organizational politics. Empirical findings suggest important policy implications for the hospitality industry.

Trajectories of Childhood Sexual Abuse and Early Adolescent HIV/AIDS Risk Behaviors: The Role of Other Maltreatment, Witnessed Violence, and Child Gender

PubMed Central

Jones, Deborah J.; Runyan, Desmond K.; Lewis, Terri; Litrownik, Alan J.; Black, Maureen M.; Wiley, Tisha; English, Diana E.; Proctor, Laura J.; Jones, Bobby L.; Nagin, Daniel S.

2013-01-01

Childhood sexual abuse (CSA) has been associated with HIV/AIDS risk behavior; however, much of this work is retrospective and focuses on women. The current study used semiparametric mixture modeling with youth (n = 844; 48.8% boys) from the Longitudinal Studies of Child Abuse and Neglect (LONGSCAN) to examine the link between trajectories of CSA (2 to 12 y.o.) and HIV/AIDS risk behavior at age 14 (i.e., sexual intercourse & alcohol use). Trajectory analyses revealed a link between a history of CSA and the development of risky behavior. In addition, trajectories for physical and emotional abuse, but not neglect or witnessed violence, contributed to risky behavior over and above the role of CSA. Child gender did not moderate the findings. Findings highlight the signficance of CSA histories, as well as the broader context of maltreatment, for better understanding the development of risk behaviors in both girls and boys. PMID:20706919

Ambivalent Sexism, Alcohol Use, and Intimate Partner Violence Perpetration.

PubMed

Renzetti, Claire M; Lynch, Kellie R; DeWall, C Nathan

2015-09-09

Research on risk factors for men's perpetration of intimate partner violence (IPV) has shown a high correlation with problem alcohol use. Additional studies, however, indicate that the alcohol-IPV link is neither simple nor necessarily direct and that a range of factors may moderate this relationship. Using a national, community-based sample of 255 men, the present study examined the moderating effects of ambivalent sexism (i.e., hostile and benevolent sexism) on the relationship between alcohol use and IPV perpetration. The findings show that both greater alcohol consumption and high hostile sexism are positively associated with IPV perpetration, and that hostile sexism moderates the alcohol-IPV relationship for perpetration of physical IPV, but not for psychological IPV. Moreover, high levels of alcohol consumption have a greater impact on physical IPV perpetration for men low in hostile sexism than for men high in hostile sexism, lending support to the multiple threshold model of the alcohol-IPV link. Implications of the findings for prevention, intervention, and future research are discussed. © The Author(s) 2015.

Different occupations associated with amyotrophic lateral sclerosis: is diesel exhaust the link?

PubMed

Pamphlett, Roger; Rikard-Bell, Anna

2013-01-01

The cause of sporadic amyotrophic lateral sclerosis (SALS) remains unknown. We attempted to find out if occupational exposure to toxicants plays a part in the pathogenesis of this disease. In an Australia-wide case-control study we compared the lifetime occupations of 611 SALS and 775 control individuals. Occupations were coded using country-specific as well as international classifications. The risk of SALS for each occupation was calculated with odds ratios using logistic regression. In addition, the literature was searched for possible toxicant links between our findings and previously-reported occupational associations with SALS. Male occupations in our study that required lower skills and tasks tended to have increased risks of SALS, and conversely, those occupations that required higher skills and tasks had decreased risks of SALS. Of all the occupations, only truck drivers, where exposure to diesel exhaust is common, maintained an increased risk of SALS throughout all occupational groups. Another large case-control study has also found truck drivers to be at risk of SALS, and almost two-thirds of occupations, as well as military duties, that have previously been associated with SALS have potential exposure to diesel exhaust. In conclusion, two of the largest case-control studies of SALS have now found that truck drivers have an increased risk of SALS. Since exposure to diesel exhaust is common in truck drivers, as well as in other occupations that have been linked to SALS, exposure to this toxicant may underlie some of the occupations that are associated with SALS.

Vegetarian diets in the Adventist Health Study 2: a review of initial published findings1234

PubMed Central

Orlich, Michael J; Fraser, Gary E

2014-01-01

The Adventist Health Study 2 is a large cohort that is well suited to the study of the relation of vegetarian dietary patterns to health and disease risk. Here we review initial published findings with regard to vegetarian diets and several health outcomes. Vegetarian dietary patterns were associated with lower body mass index, lower prevalence and incidence of diabetes mellitus, lower prevalence of the metabolic syndrome and its component factors, lower prevalence of hypertension, lower all-cause mortality, and in some instances, lower risk of cancer. Findings with regard to factors related to vegetarian diets and bone health are also reviewed. These initial results show important links between vegetarian dietary patterns and improved health. PMID:24898223

A Historical Study to Understand Students' Current Difficulties about RMS Values

ERIC Educational Resources Information Center

Khantine-Langlois, Françoise; Munier, Valérie

2016-01-01

Several studies show that students experience more and more difficulties managing the measurements of electrical values in alternating current and that they have trouble making links between theory and practice. They find it difficult to give meaning to root mean square (RMS; or effective) values, which are not understood as average values and are…

The Open Access Availability of Library and Information Science Literature

ERIC Educational Resources Information Center

Way, Doug

2010-01-01

To examine the open access availability of Library and Information Science (LIS) research, a study was conducted using Google Scholar to search for articles from 20 top LIS journals. The study examined whether Google Scholar was able to find any links to full text, if open access versions of the articles were available and where these articles…

Early Behavioral Self-Regulation, Academic Achievement, and Gender: Longitudinal Findings from France, Germany, and Iceland

ERIC Educational Resources Information Center

Gestsdottir, Steinunn; von Suchodoletz, Antje; Wanless, Shannon B.; Hubert, Blandine; Guimard, Philippe; Birgisdottir, Freyja; Gunzenhauser, Catherine; McClelland, Megan

2014-01-01

Research suggests that behavioral self-regulation skills are critical for early school success, but few studies have explored such links among young children in Europe. This study examined the contribution of early self-regulation to academic achievement gains among children in France, Germany, and Iceland. Gender differences in behavioral…

Executive Functioning and School Readiness among Preschoolers with Externalizing Problems: The Moderating Role of the Student-Teacher Relationship

ERIC Educational Resources Information Center

Graziano, Paulo A.; Garb, Leanna R.; Ros, Rosmary; Hart, Katie; Garcia, Alexis

2016-01-01

Research Findings: The objective of this study was to examine the student-teacher relationship as a potential moderator of the link between executive functioning (EF) and children's early school readiness among a clinical sample of preschoolers with externalizing behavior problems (EBP). Participants for the study included 139 preschool children…

Evaluating JTPA Programs for Economically Disadvantaged Adults: A Case Study of Utah and General Findings. Research Report No. 92-02.

ERIC Educational Resources Information Center

Bowman, William R.

A study examined the feasibility of using a "nonexperimental" technique to evaluate Job Training Partnership Act (JTPA) programs for economically disadvantaged adults. New statistical techniques were applied to data about a sample of Utah JTPA participants and data about Employment Security registrants linked with their individual…

Student Experience of School Science

ERIC Educational Resources Information Center

Shirazi, Shaista

2017-01-01

This paper presents the findings of a two-phase mixed methods research study that explores the link between experiences of school science of post-16 students and their decisions to take up science for their higher studies. In the first phase, students aged 16-17 (n = 569) reflected on the past five years of their school science experience in a…

Neuropsychiatric Disorders Associated with Streptococcal Infection: A Case-Control Study among Privately Insured Children

ERIC Educational Resources Information Center

Leslie, Douglas L.; Kozma, Laura; Martin, Andres; Landeros, Angeli; Katsovich, Liliya; King, Robert A.; Leckman, James F.

2008-01-01

The link between streptococcal infections and the onset of a variety of neuropsychiatric disorders is studied using a national sample of privately insured children. Findings suggest that patients with new-onset of obsessive-compulsive disorder, Tourette syndrome or tic orders were more likely to have been diagnosed with streptococcal infections in…

Bridging the Gap: Linking School and the World of Work in Ghana

ERIC Educational Resources Information Center

Anamuah-Mensah, Jophus; Asabere-Ameyaw, Akwasi; Dennis, Stephen

2007-01-01

The study sought to find out the views of pupils, teachers and parents on the usefulness of the educational curriculum (i.e. organization, content and methodology) and co-curricular activities in the preparation of pupils for future employment. Questionnaires and focus group discussions were used in collecting data for the study across the length…

Theory of Mind in Children with and without Autism Spectrum Disorder: Associations with the Sibling Constellation

ERIC Educational Resources Information Center

Matthews, Nicole L.; Goldberg, Wendy A.

2018-01-01

The two prior studies that have examined associations between the sibling constellation and theory of mind in autism spectrum disorder yielded discrepant findings. Thus, efforts to better understand the sibling-theory of mind link in autism spectrum disorder are necessary. This study examined a sample of prekindergarten- and kindergarten-aged…

Prenatal Inflammation Linked to Autism Risk

MedlinePlus

... Thursday, January 24, 2013 Prenatal inflammation linked to autism risk Maternal inflammation during early pregnancy may be related to an increased risk of autism in children, according to new findings supported by ...

Impact of Psychopathy on Moral Judgments about Causing Fear and Physical Harm

PubMed Central

2015-01-01

Psychopathy is a personality variable associated with persistent immoral behaviors. Despite this, attempts to link moral reasoning deficits to psychopathic traits have yielded mixed results with many findings supporting intact moral reasoning in individuals with psychopathic traits. Abundant evidence shows that psychopathy impairs responses to others’ emotional distress. However, most studies of morality and psychopathy focus on judgments about causing others physical harm. Results of such studies may be inconsistent because physical harm is an imperfect proxy for emotional distress. No previous paradigm has explicitly separated judgments about physical harm and emotional distress and assessed how psychopathy affects each type of judgment. In three studies we found that psychopathy impairs judgments about causing others emotional distress (specifically fear) but minimally affects judgments about causing physical harm and that judgments about causing fear predict instrumental aggression in psychopathy. These findings are consistent with reports linking psychopathy to insensitivity to others’ fear, and suggest that sensitivity to others’ fear may play a fundamental role in the types of moral decision-making impaired by psychopathy. PMID:25992566

Making the case for mobile cognition: EEG and sports performance.

PubMed

Park, Joanne L; Fairweather, Malcolm M; Donaldson, David I

2015-05-01

In the high stakes world of International sport even the smallest change in performance can make the difference between success and failure, leading sports professionals to become increasingly interested in the potential benefits of neuroimaging. Here we describe evidence from EEG studies that either identify neural signals associated with expertise in sport, or employ neurofeedback to improve performance. Evidence for the validity of neurofeedback as a technique for enhancing sports performance remains limited. By contrast, progress in characterizing the neural correlates of sporting behavior is clear: frequency domain studies link expert performance to changes in alpha rhythms, whilst time-domain studies link expertise in response evaluation and motor output with modulations of P300 effects and readiness potentials. Despite early promise, however, findings have had relatively little impact for sports professionals, at least in part because there has been a mismatch between lab tasks and real sporting activity. After selectively reviewing existing findings and outlining limitations, we highlight developments in mobile EEG technology that offer new opportunities for sports neuroscience. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Resistance training and older adults' beliefs about psychological benefits: the importance of self-efficacy and social interaction.

PubMed

Dionigi, Rylee

2007-12-01

The purpose of this study was to determine the perceived psychological benefits and explore the mechanisms underlying the link between exercise and psychological well-being for a group of older adults (65-72 years; 6 women; 4 men) who participated in a 12-week program of moderate-to-high intensity resistance training. They were interviewed in-depth at 1 week preintervention, 1 month after commencement, and 1 week after completion. The participants believed that resistance training enhanced their well-being, and they gave various physical, mental, and social reasons to explain this link. In particular, self-efficacy and social interaction were found to be key mechanisms underlying this relationship. This study exposed meaningful perceived improvements in psychological wellbeing that have not been uncovered in quantitative studies of healthy older people undertaking resistance training. The findings highlight the importance of using qualitative methods to enrich understandings of the positive effect of exercise on psychological well-being. The findings also have implications for designing effective resistance training interventions for older people.

Can people find patient decision aids on the Internet?

PubMed

Morris, Debra; Drake, Elizabeth; Saarimaki, Anton; Bennett, Carol; O'Connor, Annette

2008-12-01

To determine if people could find patient decision aids (PtDAs) on the Internet using the most popular general search engines. We chose five medical conditions for which English language PtDAs were available from at least three different developers. The search engines used were: Google (www.google.com), Yahoo! (www.yahoo.com), and MSN (www.msn.com). For each condition and search engine we ran six searches using a combination of search terms. We coded all non-sponsored Web pages that were linked from the first page of the search results. Most first page results linked to informational Web pages about the condition, only 16% linked to PtDAs. PtDAs were more readily found for the breast cancer surgery decision (our searches found seven of the nine developers). The searches using Yahoo and Google search engines were more likely to find PtDAs. The following combination of search terms: condition, treatment, decision (e.g. breast cancer surgery decision) was most successful across all search engines (29%). While some terms and search engines were more successful, few resulted in direct links to PtDAs. Finding PtDAs would be improved with use of standardized labelling, providing patients with specific Web site addresses or access to an independent PtDA clearinghouse.

Glycosylation patterns of kidney proteins differ in rat diabetic nephropathy.

PubMed

Ravidà, Alessandra; Musante, Luca; Kreivi, Marjut; Miinalainen, Ilkka; Byrne, Barry; Saraswat, Mayank; Henry, Michael; Meleady, Paula; Clynes, Martin; Holthofer, Harry

2015-05-01

Diabetic nephropathy often progresses to end-stage kidney disease and, ultimately, to renal replacement therapy. Hyperglycemia per se is expected to have a direct impact on the biosynthesis of N- and O-linked glycoproteins. This study aims to establish the link between protein glycosylation and progression of experimental diabetic kidney disease using orthogonal methods. Kidneys of streptozotocin-diabetic and control rats were harvested at three different time points post streptozotocin injection. A panel of 12 plant lectins was used in the screening of lectin blots. The lectins UEAI, PHA-E, GSI, PNA, and RCA identified remarkable disease-associated differences in glycoprotein expression. Lectin affinity chromatography followed by mass spectrometric analyses led to the identification of several glycoproteins involved in salt-handling, angiogenesis, and extracellular matrix degradation. Our data confirm a substantial link between glycosylation signature and diabetes progression. Furthermore, as suggested by our findings on dipeptidyl peptidase-IV, altered protein glycosylation may reflect changes in biochemical properties such as enzymatic activity. Thus, our study demonstrates the unexplored potential of protein glycosylation analysis in the discovery of molecules linked to diabetic kidney disease.

Clinical utility of the X-chromosome array.

PubMed

Zarate, Yuri A; Dwivedi, Alka; Bartel, Frank O; Bellomo, M Allison; Cathey, Sara S; Champaigne, Neena L; Clarkson, L Kate; Dupont, Barbara R; Everman, David B; Geer, Joseph S; Gordon, Barbara C; Lichty, Angie W; Lyons, Michael J; Rogers, R Curtis; Saul, Robert A; Schroer, Richard J; Skinner, Steven A; Stevenson, Roger E

2013-01-01

Previous studies have limited the use of specific X-chromosome array designed platforms to the evaluation of patients with intellectual disability. In this retrospective analysis, we reviewed the clinical utility of an X-chromosome array in a variety of scenarios. We divided patients according to the indication for the test into four defined categories: (1) autism spectrum disorders and/or developmental delay and/or intellectual disability (ASDs/DD/ID) with known family history of neurocognitive disorders; (2) ASDs/DD/ID without known family history of neurocognitive disorders; (3) breakpoint definition of an abnormality detected by a different cytogenetic test; and (4) evaluation of suspected or known X-linked conditions. A total of 59 studies were ordered with 27 copy number variants detected in 25 patients (25/59 = 42%). The findings were deemed pathogenic/likely pathogenic (16/59 = 27%), benign (4/59 = 7%) or uncertain (7/59 = 12%). We place particular emphasis on the utility of this test for the diagnostic evaluation of families affected with X-linked conditions and how it compares to whole genome arrays in this setting. In conclusion, the X-chromosome array frequently detects genomic alterations of the X chromosome and it has advantages when evaluating some specific X-linked conditions. However, careful interpretation and correlation with clinical findings is needed to determine the significance of such changes. When the X-chromosome array was used to confirm a suspected X-linked condition, it had a yield of 63% (12/19) and was useful in the evaluation and risk assessment of patients and families. Copyright © 2012 Wiley Periodicals, Inc.

An assessment of molecular pathways of obesity susceptible to nutrient, toxicant and genetically induced epigenetic perturbation

PubMed Central

Xue, Jing; Ideraabdullah, Folami Y.

2015-01-01

In recent years, the etiology of human disease has greatly improved with the inclusion of epigenetic mechanisms, in particular as a common link between environment and disease. However, for most diseases we lack a detailed interpretation of the epigenetic regulatory pathways perturbed by environment and causal mechanisms. Here, we focus on recent findings elucidating nutrient-related epigenetic changes linked to obesity. We highlight studies demonstrating that obesity is a complex disease linked to disruption of epigenetically regulated metabolic pathways in the brain, adipose tissue and liver. These pathways regulate (1) homeostatic and hedonic eating behaviors (2) adipocyte differentiation and fat accumulation, and (3) energy expenditure. By compiling these data we illustrate that obesity-related phenotypes are repeatedly linked to disruption of critical epigenetic mechanisms that regulate of key metabolic genes. These data are supported by genetic mutation of key epigenetic regulators and many of the diet induced epigenetic mechanisms of obesity are also perturbed by exposure to environmental toxicants. Identifying similarly perturbed epigenetic mechanisms in multiple experimental models of obesity strengthens the translational applications of these findings. We also discuss many of the ongoing challenges to understanding the role of environmentally-induced epigenetic pathways in obesity and suggest future studies to elucidate these roles. This assessment illustrates our current understanding of molecular pathways of obesity that are susceptible to environmental perturbation via epigenetic mechanisms. Thus, it lays the groundwork for dissecting the complex interactions between diet, genes, and toxicants that contribute to obesity and obesity-related phenotypes. PMID:27012616

Altered striatal circuits underlie characteristic personality traits in Parkinson's disease.

PubMed

Ishii, Toru; Sawamoto, Nobukatsu; Tabu, Hayato; Kawashima, Hidekazu; Okada, Tomohisa; Togashi, Kaori; Takahashi, Ryosuke; Fukuyama, Hidenao

2016-09-01

Patients with Parkinson's disease (PD) have been suggested to share personality traits characterised by low novelty-seeking and high harm-avoidance. Although a link between novelty-seeking and dopamine is hypothesised, the link is not fully supported by 6-[(18)F]fluoro-L-dopa positron emission tomography (PET) studies. Meanwhile, tractography studies with magnetic resonance imaging (MRI) link personality to the connectivity of the striatum in healthy subjects. Here, we investigated neurochemical and anatomical correlates of characteristic personality traits in PD. Sixteen PD patients and 28 healthy controls were assessed using the Temperament and Character Inventory. All patients and 17 randomly selected controls were scanned with 2β-carbomethoxy-3β-(4-fluorophenyl)-[N-(11)C-methyl]tropane ([(11)C]CFT) PET to measure striatal dopamine transporter availability. All subjects were scanned with MRI to evaluate the connectivity of the striatum using probabilistic tractography. PET findings revealed no correlation of novelty-seeking and harm-avoidance with [(11)C]CFT uptake in patients or controls. Novelty-seeking correlated positively with the connectivity strength of the striatum with the hippocampus and amygdala in both patients and controls. Harm-avoidance and the fibre connectivity strength of the striatum including ventral area with the amygdala correlated negatively in patients and positively in controls, which differed significantly between the groups. Our data support the notion that the fibre connectivity of the striatum with limbic and frontal areas underlies the personality profile. Furthermore, our findings suggest that higher harm-avoidance in PD is linked to alterations of the network, including the nucleus accumbens and amygdala.

Early Childhood Maltreatment and Girls' Sexual Behavior: The Mediating Role of Pubertal Timing.

PubMed

Ryan, Rebecca M; Mendle, Jane; Markowitz, Anna J

2015-09-01

Although links between early childhood maltreatment and girls' sexual behavior in adolescence have been well established, it is unclear whether different forms of maltreatment are differentially associated with sexual outcomes and whether distinct mechanisms explain associations across maltreatment types. Using data from National Longitudinal Study of Adolescent Health (Add Health), the present study examines whether physical abuse, sexual abuse, and physical neglect in early childhood differentially predict girls' age at first intercourse and number of sexual partners in early adulthood. The study also tests whether early pubertal timing mediates the link between early maltreatment and sexual behavior (N = 6,364). Findings indicate that early sexual and physical abuse were equally predictive of earlier age at first intercourse and a greater number of sexual partners, but that only the sexual abuse-age at first intercourse link was mediated by early puberty. These results suggest that sexual abuse and physical abuse are associated with earlier and riskier sexual behavior in girls relative to no maltreatment and to similar degrees. However, only the link between sexual abuse and sexual behavior involves a biological mechanism manifested in early pubertal timing. Copyright © 2015 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

Two Linked Enteroinvasive Escherichia coli Outbreaks, Nottingham, UK, June 2014

PubMed Central

MacGregor, Vanessa; Robbins, Vivienne; Bayliss, Laura; Chattaway, Marie Anne; Dallman, Tim; Ready, Derren; Aird, Heather; Puleston, Richard; Hawker, Jeremy

2016-01-01

Enteroinvasive Escherichia coli (EIEC) outbreaks are uncommon in Europe. In June 2014, two EIEC outbreaks occurred in Nottingham, UK, within 2 days; outbreak A was linked to a takeaway restaurant and outbreak B to a wedding party. We conducted 2 analytical studies: a case–control study for outbreak A and a cohort study for outbreak B. We tested microbiological and environmental samples, including by using whole-genome sequencing. For both outbreaks combined, we identified 157 probable case-patients; 27 were laboratory-confirmed as EIEC O96:H19–positive. Combined epidemiologic, microbiological, and environmental findings implicated lettuce as the vehicle of infection in outbreak A, but the source of the organism remained unknown. Whole-genome sequencing identified the same organism in cases from both outbreaks, but no epidemiologic link was confirmed. These outbreaks highlight that EIEC has the capacity to cause large and severe gastrointestinal disease outbreaks and should be considered as a potential pathogen in foodborne outbreaks in Europe. PMID:27314432

Two Linked Enteroinvasive Escherichia coli Outbreaks, Nottingham, UK, June 2014.

PubMed

Newitt, Sophie; MacGregor, Vanessa; Robbins, Vivienne; Bayliss, Laura; Chattaway, Marie Anne; Dallman, Tim; Ready, Derren; Aird, Heather; Puleston, Richard; Hawker, Jeremy

2016-07-01

Enteroinvasive Escherichia coli (EIEC) outbreaks are uncommon in Europe. In June 2014, two EIEC outbreaks occurred in Nottingham, UK, within 2 days; outbreak A was linked to a takeaway restaurant and outbreak B to a wedding party. We conducted 2 analytical studies: a case-control study for outbreak A and a cohort study for outbreak B. We tested microbiological and environmental samples, including by using whole-genome sequencing. For both outbreaks combined, we identified 157 probable case-patients; 27 were laboratory-confirmed as EIEC O96:H19-positive. Combined epidemiologic, microbiological, and environmental findings implicated lettuce as the vehicle of infection in outbreak A, but the source of the organism remained unknown. Whole-genome sequencing identified the same organism in cases from both outbreaks, but no epidemiologic link was confirmed. These outbreaks highlight that EIEC has the capacity to cause large and severe gastrointestinal disease outbreaks and should be considered as a potential pathogen in foodborne outbreaks in Europe.

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

PubMed

Horikoshi, Momoko; Yaghootkar, Hanieh; Mook-Kanamori, Dennis O; Sovio, Ulla; Taal, H Rob; Hennig, Branwen J; Bradfield, Jonathan P; St Pourcain, Beate; Evans, David M; Charoen, Pimphen; Kaakinen, Marika; Cousminer, Diana L; Lehtimäki, Terho; Kreiner-Møller, Eskil; Warrington, Nicole M; Bustamante, Mariona; Feenstra, Bjarke; Berry, Diane J; Thiering, Elisabeth; Pfab, Thiemo; Barton, Sheila J; Shields, Beverley M; Kerkhof, Marjan; van Leeuwen, Elisabeth M; Fulford, Anthony J; Kutalik, Zoltán; Zhao, Jing Hua; den Hoed, Marcel; Mahajan, Anubha; Lindi, Virpi; Goh, Liang-Kee; Hottenga, Jouke-Jan; Wu, Ying; Raitakari, Olli T; Harder, Marie N; Meirhaeghe, Aline; Ntalla, Ioanna; Salem, Rany M; Jameson, Karen A; Zhou, Kaixin; Monies, Dorota M; Lagou, Vasiliki; Kirin, Mirna; Heikkinen, Jani; Adair, Linda S; Alkuraya, Fowzan S; Al-Odaib, Ali; Amouyel, Philippe; Andersson, Ehm Astrid; Bennett, Amanda J; Blakemore, Alexandra I F; Buxton, Jessica L; Dallongeville, Jean; Das, Shikta; de Geus, Eco J C; Estivill, Xavier; Flexeder, Claudia; Froguel, Philippe; Geller, Frank; Godfrey, Keith M; Gottrand, Frédéric; Groves, Christopher J; Hansen, Torben; Hirschhorn, Joel N; Hofman, Albert; Hollegaard, Mads V; Hougaard, David M; Hyppönen, Elina; Inskip, Hazel M; Isaacs, Aaron; Jørgensen, Torben; Kanaka-Gantenbein, Christina; Kemp, John P; Kiess, Wieland; Kilpeläinen, Tuomas O; Klopp, Norman; Knight, Bridget A; Kuzawa, Christopher W; McMahon, George; Newnham, John P; Niinikoski, Harri; Oostra, Ben A; Pedersen, Louise; Postma, Dirkje S; Ring, Susan M; Rivadeneira, Fernando; Robertson, Neil R; Sebert, Sylvain; Simell, Olli; Slowinski, Torsten; Tiesler, Carla M T; Tönjes, Anke; Vaag, Allan; Viikari, Jorma S; Vink, Jacqueline M; Vissing, Nadja Hawwa; Wareham, Nicholas J; Willemsen, Gonneke; Witte, Daniel R; Zhang, Haitao; Zhao, Jianhua; Wilson, James F; Stumvoll, Michael; Prentice, Andrew M; Meyer, Brian F; Pearson, Ewan R; Boreham, Colin A G; Cooper, Cyrus; Gillman, Matthew W; Dedoussis, George V; Moreno, Luis A; Pedersen, Oluf; Saarinen, Maiju; Mohlke, Karen L; Boomsma, Dorret I; Saw, Seang-Mei; Lakka, Timo A; Körner, Antje; Loos, Ruth J F; Ong, Ken K; Vollenweider, Peter; van Duijn, Cornelia M; Koppelman, Gerard H; Hattersley, Andrew T; Holloway, John W; Hocher, Berthold; Heinrich, Joachim; Power, Chris; Melbye, Mads; Guxens, Mònica; Pennell, Craig E; Bønnelykke, Klaus; Bisgaard, Hans; Eriksson, Johan G; Widén, Elisabeth; Hakonarson, Hakon; Uitterlinden, André G; Pouta, Anneli; Lawlor, Debbie A; Smith, George Davey; Frayling, Timothy M; McCarthy, Mark I; Grant, Struan F A; Jaddoe, Vincent W V; Jarvelin, Marjo-Riitta; Timpson, Nicholas J; Prokopenko, Inga; Freathy, Rachel M

2013-01-01

Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

PubMed Central

Horikoshi, Momoko; Yaghootkar, Hanieh; Mook-Kanamori, Dennis O.; Sovio, Ulla; Taal, H. Rob; Hennig, Branwen J.; Bradfield, Jonathan P.; St. Pourcain, Beate; Evans, David M.; Charoen, Pimphen; Kaakinen, Marika; Cousminer, Diana L.; Lehtimäki, Terho; Kreiner-Møller, Eskil; Warrington, Nicole M.; Bustamante, Mariona; Feenstra, Bjarke; Berry, Diane J.; Thiering, Elisabeth; Pfab, Thiemo; Barton, Sheila J.; Shields, Beverley M.; Kerkhof, Marjan; van Leeuwen, Elisabeth M.; Fulford, Anthony J.; Kutalik, Zoltán; Zhao, Jing Hua; den Hoed, Marcel; Mahajan, Anubha; Lindi, Virpi; Goh, Liang-Kee; Hottenga, Jouke-Jan; Wu, Ying; Raitakari, Olli T.; Harder, Marie N.; Meirhaeghe, Aline; Ntalla, Ioanna; Salem, Rany M.; Jameson, Karen A.; Zhou, Kaixin; Monies, Dorota M.; Lagou, Vasiliki; Kirin, Mirna; Heikkinen, Jani; Adair, Linda S.; Alkuraya, Fowzan S.; Al-Odaib, Ali; Amouyel, Philippe; Andersson, Ehm Astrid; Bennett, Amanda J.; Blakemore, Alexandra I.F.; Buxton, Jessica L.; Dallongeville, Jean; Das, Shikta; de Geus, Eco J. C.; Estivill, Xavier; Flexeder, Claudia; Froguel, Philippe; Geller, Frank; Godfrey, Keith M.; Gottrand, Frédéric; Groves, Christopher J.; Hansen, Torben; Hirschhorn, Joel N.; Hofman, Albert; Hollegaard, Mads V.; Hougaard, David M.; Hyppönen, Elina; Inskip, Hazel M.; Isaacs, Aaron; Jørgensen, Torben; Kanaka-Gantenbein, Christina; Kemp, John P.; Kiess, Wieland; Kilpeläinen, Tuomas O.; Klopp, Norman; Knight, Bridget A.; Kuzawa, Christopher W.; McMahon, George; Newnham, John P.; Niinikoski, Harri; Oostra, Ben A.; Pedersen, Louise; Postma, Dirkje S.; Ring, Susan M.; Rivadeneira, Fernando; Robertson, Neil R.; Sebert, Sylvain; Simell, Olli; Slowinski, Torsten; Tiesler, Carla M.T.; Tönjes, Anke; Vaag, Allan; Viikari, Jorma S.; Vink, Jacqueline M.; Vissing, Nadja Hawwa; Wareham, Nicholas J.; Willemsen, Gonneke; Witte, Daniel R.; Zhang, Haitao; Zhao, Jianhua; Wilson, James F.; Stumvoll, Michael; Prentice, Andrew M.; Meyer, Brian F.; Pearson, Ewan R.; Boreham, Colin A.G.; Cooper, Cyrus; Gillman, Matthew W.; Dedoussis, George V.; Moreno, Luis A; Pedersen, Oluf; Saarinen, Maiju; Mohlke, Karen L.; Boomsma, Dorret I.; Saw, Seang-Mei; Lakka, Timo A.; Körner, Antje; Loos, Ruth J.F.; Ong, Ken K.; Vollenweider, Peter; van Duijn, Cornelia M.; Koppelman, Gerard H.; Hattersley, Andrew T.; Holloway, John W.; Hocher, Berthold; Heinrich, Joachim; Power, Chris; Melbye, Mads; Guxens, Mònica; Pennell, Craig E.; Bønnelykke, Klaus; Bisgaard, Hans; Eriksson, Johan G.; Widén, Elisabeth; Hakonarson, Hakon; Uitterlinden, André G.; Pouta, Anneli; Lawlor, Debbie A.; Smith, George Davey; Frayling, Timothy M.; McCarthy, Mark I.; Grant, Struan F.A.; Jaddoe, Vincent W.V.; Jarvelin, Marjo-Riitta; Timpson, Nicholas J.; Prokopenko, Inga; Freathy, Rachel M.

2012-01-01

Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood1. Previous genome-wide association studies identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes, and a second variant, near CCNL1, with no obvious link to adult traits2. In an expanded genome-wide association meta-analysis and follow-up study (up to 69,308 individuals of European descent from 43 studies), we have now extended the number of genome-wide significant loci to seven, accounting for a similar proportion of variance to maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes; ADRB1 with adult blood pressure; and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism. PMID:23202124

Combined node and link partitions method for finding overlapping communities in complex networks

PubMed Central

Jin, Di; Gabrys, Bogdan; Dang, Jianwu

2015-01-01

Community detection in complex networks is a fundamental data analysis task in various domains, and how to effectively find overlapping communities in real applications is still a challenge. In this work, we propose a new unified model and method for finding the best overlapping communities on the basis of the associated node and link partitions derived from the same framework. Specifically, we first describe a unified model that accommodates node and link communities (partitions) together, and then present a nonnegative matrix factorization method to learn the parameters of the model. Thereafter, we infer the overlapping communities based on the derived node and link communities, i.e., determine each overlapped community between the corresponding node and link community with a greedy optimization of a local community function conductance. Finally, we introduce a model selection method based on consensus clustering to determine the number of communities. We have evaluated our method on both synthetic and real-world networks with ground-truths, and compared it with seven state-of-the-art methods. The experimental results demonstrate the superior performance of our method over the competing ones in detecting overlapping communities for all analysed data sets. Improved performance is particularly pronounced in cases of more complicated networked community structures. PMID:25715829

Apprenticeships Link Community-Technical Colleges and Business and Industry for Workforce Training.

ERIC Educational Resources Information Center

Cantor, Jeffrey A.

1995-01-01

Presents findings from a case study of factors influencing successful cooperative apprenticeship programs. Indicates that apprenticeships are cost-effective mechanisms for bringing together the human and capital resources within a community to solve human resource education and business training needs. (21 citations). (MAB)

Inmate Movements and Prison Uprisings: A Comparative Study.

ERIC Educational Resources Information Center

Pederson, William D.

1978-01-01

Fifteen "criminal" and political uprisings from inmate movements in American, Soviet, and German prisons are compared. Conditions of deprivation related to prison violence are linked with attitudinal, structural, and temporal factors. Findings are that inmate movements are a rare phenomenon in comparison with isolated prison uprisings. (KC)

Residential Mobility, Inhibitory Control, and Academic Achievement in Preschool

ERIC Educational Resources Information Center

Schmitt, Sara A.; Finders, Jennifer K.; McClelland, Megan M.

2015-01-01

Research Findings: The present study investigated the direct effects of residential mobility on children's inhibitory control and academic achievement during the preschool year. It also explored fall inhibitory control and academic skills as mediators linking residential mobility and spring achievement. Participants included 359 preschool children…

Plant cytoskeleton: DELLA connects gibberellins to microtubules.

PubMed

Dixit, Ram

2013-06-03

A new study reveals that DELLA proteins directly interact with the prefoldin complex, thus regulating tubulin subunit availability in a gibberellin-dependent manner. This finding provides a mechanistic link between the growth-promoting plant hormone gibberellin and cortical microtubule organization. Copyright © 2013 Elsevier Ltd. All rights reserved.

Health of Aging Parents and Childless Individuals

ERIC Educational Resources Information Center

Kendig, Hal; Dykstra, Pearl A.; van Gaalen, Ruben I.; Melkas, Tuula

2007-01-01

This article reviews and presents research findings on the relationships between parenthood and health over the life span. Existing research shows lacunae. The links between reproductive behavior and longevity generally focus on family size rather than contrasting parents and nonparents. Studies of marital status differentials in survival…

Role of solvent-mediated carbodiimide cross-linking in fabrication of electrospun gelatin nanofibrous membranes as ophthalmic biomaterials.

PubMed

Chou, Shih-Feng; Luo, Li-Jyuan; Lai, Jui-Yang; Ma, David Hui-Kang

2017-02-01

Due to their ability to mimic the structure of extracellular matrix, electrospun gelatin nanofibers are promising cell scaffolding materials for tissue engineering applications. However, the hydrophilic gelatin molecules usually need stabilization before use in aqueous physiological environment. Considering that biomaterials cross-linked via film immersion technique may have a more homogeneous cross-linked structure than vapor phase cross-linking, this work aims to investigate the chemical modification of electrospun gelatin nanofibrous membranes by liquid phase carbodiimide in the presence of ethanol/water co-solvents with varying ethanol concentrations ranging from 80 to 99.5vol%. The results of characterization showed that increasing water content in the binary reaction solvent system increases the extent of cross-linking of gelatin nanofibers, but simultaneously promotes the effect of biopolymer swelling and distortion in fiber mat structure. As compared to non-cross-linked counterparts, carbodiimide treated gelatin nanofibrous mats exhibited better thermal and biological stability where the shrinkage temperature and resistance to enzymatic degradation varied in response to ethanol/water solvent composition-mediated generation of cross-links. Irrespective of their cross-linking density, all studied membrane samples did not induce any responses in ocular epithelial cell cultures derived from cornea, lens, and retina. Unlike many other cross-linking agents and/or methods (e.g., excessive vapor phase cross-linking) that may pose a risk of toxicity, our study demonstrated that these nanofibrous materials are well tolerated by anterior segment tissues. These findings also indicate the safety of using ethanol/water co-solvents for chemical cross-linking of gelatin to engineer nanofibrous materials with negligible biological effects. In summary, the present results suggest the importance of solvent-mediated carbodiimide cross-linking in modulating structure-property relationship without compromising in vitro and in vivo biocompatibility of electrospun gelatin nanofibers for future ophthalmic applications. Copyright © 2016 Elsevier B.V. All rights reserved.

Collective helping and bystander effects in coevolving helping networks.

PubMed

Jo, Hang-Hyun; Lee, Hyun Keun; Park, Hyunggyu

2010-06-01

We study collective helping behavior and bystander effects in a coevolving helping network model. A node and a link of the network represents an agent who renders or receives help and a friendly relation between agents, respectively. A helping trial of an agent depends on relations with other involved agents and its result (success or failure) updates the relation between the helper and the recipient. We study the network link dynamics and its steady states analytically and numerically. The full phase diagram is presented with various kinds of active and inactive phases and the nature of phase transitions are explored. We find various interesting bystander effects, consistent with the field study results, of which the underlying mechanism is proposed.

Improving Website Hyperlink Structure Using Server Logs

PubMed Central

Paranjape, Ashwin; West, Robert; Zia, Leila; Leskovec, Jure

2016-01-01

Good websites should be easy to navigate via hyperlinks, yet maintaining a high-quality link structure is difficult. Identifying pairs of pages that should be linked may be hard for human editors, especially if the site is large and changes frequently. Further, given a set of useful link candidates, the task of incorporating them into the site can be expensive, since it typically involves humans editing pages. In the light of these challenges, it is desirable to develop data-driven methods for automating the link placement task. Here we develop an approach for automatically finding useful hyperlinks to add to a website. We show that passively collected server logs, beyond telling us which existing links are useful, also contain implicit signals indicating which nonexistent links would be useful if they were to be introduced. We leverage these signals to model the future usefulness of yet nonexistent links. Based on our model, we define the problem of link placement under budget constraints and propose an efficient algorithm for solving it. We demonstrate the effectiveness of our approach by evaluating it on Wikipedia, a large website for which we have access to both server logs (used for finding useful new links) and the complete revision history (containing a ground truth of new links). As our method is based exclusively on standard server logs, it may also be applied to any other website, as we show with the example of the biomedical research site Simtk. PMID:28345077

Understanding traffic dynamics at a backbone POP

NASA Astrophysics Data System (ADS)

Taft, Nina; Bhattacharyya, Supratik; Jetcheva, Jorjeta; Diot, Christophe

2001-07-01

Spatial and temporal information about traffic dynamics is central to the design of effective traffic engineering practices for IP backbones. In this paper we study backbone traffic dynamics using data collected at a major POP on a tier-1 IP backbone. We develop a methodology that combines packet-level traces from access links in the POP and BGP routing information to build components of POP-to-POP traffic matrices. Our results show that there is wide disparity in the volume of traffic headed towards different egress POPs. At the same time, we find that current routing practices in the backbone tend to constrain traffic between ingress-egress POP pairs to a small number of paths. As a result, there is a wide variation in the utilization level of links in the backbone. Frequent capacity upgrades of the heavily used links are expensive; the need for such upgrades can be reduced by designing load balancing policies that will route more traffic over less utilized links. We identify traffic aggregates based on destination address prefixes and find that this set of criteria isolates a few aggregates that account for an overwhelmingly large portion of inter-POP traffic. We also demonstrate that these aggregates exhibit stability throughout the day on per-hour time scales, and thus they form a natural basis for splitting traffic over multiple paths in order to improve load balancing.

Teacher-student interpersonal relationships do change and affect academic motivation: a multilevel growth curve modelling.

PubMed

Maulana, Ridwan; Opdenakker, Marie-Christine; Bosker, Roel

2014-09-01

Research has shown that the teacher-student interpersonal relationship (TSIR) is important for student motivation. Although TSIR has received a growing interest, there are only few studies that focus on changes and links between TSIR and student academic motivation in a longitudinal fashion in non-Western contexts. This study investigated changes in TSIR and links with academic motivation as perceived by first-grade secondary school students in Indonesia. TSIR was studied from the perspective of interpersonal behaviour in terms of Influence and Proximity. Students' academic motivation was studied from the perspective of self-determination theory. A total of 504 first-grade secondary school students of 16 mathematics and English classes participated in the study. Surveys were administered in five waves throughout the school year. Multilevel growth curve modelling was applied. Contrary to the (limited) general research findings from Western contexts, we found that the quality of TSIR (student perceptions) increased over time. The increase was slightly more pronounced for Proximity than for Influence. In accordance with the findings for the Western countries, the level of students' controlled motivation increased, while that of autonomous motivation decreased over time. However, the negative change in autonomous motivation was less pronounced. As in Western countries, TSIR was longitudinally linked with academic motivation, in particular, with autonomous motivation. Evidence is found that TSIR can change in a favourable way, and this positively affects student motivation. Future research could benefit from unravelling the influences of cultures on changes in TSIR in broader contexts. © 2013 The British Psychological Society.

Impulsivity and suicidality: the mediating role of painful and provocative experiences.

PubMed

Bender, Theodore W; Gordon, Kathryn H; Bresin, Konrad; Joiner, Thomas E

2011-03-01

Multiple studies have reported a link between high levels of impulsivity and suicidal behavior. Joiner's (2005) explanation for this link is that impulsive individuals have a greater tendency to experience painful and provocative events that habituate them to fear and pain, which leads to an acquired capability for engaging in suicidal behavior. Study 1 tested Joiner's (2005) hypothesis in a sample of 182 undergraduate students who completed self-report questionnaires on impulsivity, frequency of painful and provocative events, and acquired capability for suicide. In addition to self-report, pain tolerance (an aspect of acquired capability for suicide) was measured with a pressure algometer. Study 2 sought to replicate our findings from Study 1 in a sample of 516 clinical outpatients using a multi-faceted measure of impulsivity. Consistent with prediction, product of coefficients tests for mediation (MacKinnon et al., 2002) revealed that impulsivity has an indirect relationship with acquired capability for suicidal behavior, and that this relationship is mediated by painful and provocative events. Data from our studies are cross-sectional in nature, which does not allow for conclusions about the temporal ordering of our variables. In addition, self-report was used to measure most variables. Future research may benefit from a longitudinal design and the inclusion of other modes of assessment (e.g., behavioral measures of impulsivity). Our findings suggest that the link between impulsivity and suicidal behavior occurs because impulsive people tend to have a greater capability for suicidal behavior, which they have acquired through experiencing painful and provocative events. Copyright © 2010 Elsevier B.V. All rights reserved.

Controlling self-sustained spiking activity by adding or removing one network link

NASA Astrophysics Data System (ADS)

Xu, Kesheng; Huang, Wenwen; Li, Baowen; Dhamala, Mukesh; Liu, Zonghua

2013-06-01

Being able to control the neuronal spiking activity in specific brain regions is central to a treatment scheme in several brain disorders such as epileptic seizures, mental depression, and Parkinson's diseases. Here, we present an approach for controlling self-sustained oscillations by adding or removing one directed network link in coupled neuronal oscillators, in contrast to previous approaches of adding stimuli or noise. We find that such networks can exhibit a variety of activity patterns such as on-off switch, sustained spikes, and short-term spikes. We derive the condition for a specific link to be the controller of the on-off effect. A qualitative analysis is provided to facilitate the understanding of the mechanism for spiking activity by adding one link. Our findings represent the first report on generating spike activity with the addition of only one directed link to a network and provide a deeper understanding of the microscopic roots of self-sustained spiking.

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Biogenesis of influenza a virus hemagglutinin cross-protective stem epitopes.

PubMed

Magadán, Javier G; Altman, Meghan O; Ince, William L; Hickman, Heather D; Stevens, James; Chevalier, Aaron; Baker, David; Wilson, Patrick C; Ahmed, Rafi; Bennink, Jack R; Yewdell, Jonathan W

2014-06-01

Antigenic variation in the globular domain of influenza A virus (IAV) hemagglutinin (HA) precludes effective immunity to this major human pathogen. Although the HA stem is highly conserved between influenza virus strains, HA stem-reactive antibodies (StRAbs) were long considered biologically inert. It is now clear, however, that StRAbs reduce viral replication in animal models and protect against pathogenicity and death, supporting the potential of HA stem-based immunogens as drift-resistant vaccines. Optimally designing StRAb-inducing immunogens and understanding StRAb effector functions require thorough comprehension of HA stem structure and antigenicity. Here, we study the biogenesis of HA stem epitopes recognized in cells infected with various drifted IAV H1N1 strains using mouse and human StRAbs. Using a novel immunofluorescence (IF)-based assay, we find that human StRAbs bind monomeric HA in the endoplasmic reticulum (ER) and trimerized HA in the Golgi complex (GC) with similar high avidity, potentially good news for producing effective monomeric HA stem immunogens. Though HA stem epitopes are nestled among several N-linked oligosaccharides, glycosylation is not required for full antigenicity. Rather, as N-linked glycans increase in size during intracellular transport of HA through the GC, StRAb binding becomes temperature-sensitive, binding poorly to HA at 4°C and well at 37°C. A de novo designed, 65-residue protein binds the mature HA stem independently of temperature, consistent with a lack of N-linked oligosaccharide steric hindrance due to its small size. Likewise, StRAbs bind recombinant HA carrying simple N-linked glycans in a temperature-independent manner. Chemical cross-linking experiments show that N-linked oligosaccharides likely influence StRAb binding by direct local effects rather than by globally modifying the conformational flexibility of HA. Our findings indicate that StRAb binding to HA is precarious, raising the possibility that sufficient immune pressure on the HA stem region could select for viral escape mutants with increased steric hindrance from N-linked glycans.

Mobile Learning in Foreign Language Learning: Podcasts and Lexicon Acquisition in the Elementary Instruction of Italian

ERIC Educational Resources Information Center

Unterrainer, Eva Maria

2012-01-01

This paper illustrates the research design (including the pilot study) of a work-in-progress study aimed at examining the potential of bilingual podcasts for the vocabulary acquisition in Italian as an L3 in the Austrian school context for beginning learners. The longitudinal study tries to link findings of the Lexical Approach (Lewis, 1993, 1997)…

Analysis of N- and O-linked protein glycosylation in children with Prader-Willi syndrome.

PubMed

Munce, T; Heussler, H S; Bowling, F G

2010-10-01

Current genotype-phenotype correlations in Prader-Willi syndrome (PWS) are struggling to give an explanation of the diversity in phenotype and there is a need to move towards a molecular understanding of PWS. A range of functions related to glycoproteins are involved in the pathophysiology of PWS and it may be that abnormal glycosylation is contributing to the biological phenotype. The objective of this study was to investigate the state of N- and O-linked glycosylation in children with Prader-Willi syndrome. Twenty-three children with PWS and 20 non-PWS controls were included in the study. Protein N-linked glycosylation was assessed by analysing serum transferrin through mass spectrometry and protein O-linked through isoelectric focusing (IEF) of serum apolipoprotein C-III (apoC-III), confirmed by mass spectrometry. The results of this analysis indicated that the N-linked glycosylation pathway in PWS is normal. A subgroup of PWS individuals was found to have a hyposialylated pattern of apoC-III isoforms. This was independent of the underlying genetic mechanism and is the first report of an apoC-III IEF abnormality in PWS. This is the first report of apoC-III hyposialylation in PWS. As this field is in its infancy, additional study is required before these findings may be used in clinical settings. © 2010 The Authors. Journal of Intellectual Disability Research © 2010 Blackwell Publishing Ltd.

Does Maternal Employment Following Childbirth Support or Inhibit Low-Income Children’s Long-Term Development?

PubMed Central

Coley, Rebekah Levine; Lombardi, Caitlin McPherran

2012-01-01

This study assessed whether previous findings linking early maternal employment to lower cognitive and behavioral skills among middle class and White children generalized to other groups. Using a representative sample of urban, low-income, predominantly African American and Hispanic families (n = 444), OLS regression and propensity score matching models assessed links between maternal employment in the two years after childbearing and children’s functioning at age 7. Children whose mothers were employed early, particularly in their first 8 months, showed enhanced socio-emotional functioning compared to peers whose mother remained nonemployed. Protective associations emerged for both part time and full time employment, and were driven by African American children, with neutral effects for Hispanics. Informal home-based child care also heightened positive links. PMID:22931466

Stress Generation, Avoidance Coping, and Depressive Symptoms: A 10-Year Model

PubMed Central

Holahan, Charles J.; Moos, Rudolf H.; Holahan, Carole K.; Brennan, Penny L.; Schutte, Kathleen K.

2011-01-01

This study examined (a) the role of avoidance coping in prospectively generating both chronic and acute life stressors and (b) the stress-generating role of avoidance coping as a prospective link to future depressive symptoms. Participants were 1,211 late-middle-aged individuals (500 women and 711 men) assessed 3 times over a 10-year period. As predicted, baseline avoidance coping was prospectively associated with both more chronic and more acute life stressors 4 years later. Furthermore, as predicted, these intervening life stressors linked baseline avoidance coping and depressive symptoms 10 years later, controlling for the influence of initial depressive symptoms. These findings broaden knowledge about the stress-generation process and elucidate a key mechanism through which avoidance coping is linked to depressive symptoms. PMID:16173853

Assessing the Prevalence of Intellectual Disability among Young Male Prisoners

ERIC Educational Resources Information Center

Herrington, V.

2009-01-01

Background: In recent years, academic debate has (re)focused on the extent of the co-occurrence of intellectual disability (ID) and criminality, although findings from prevalence studies examining this link have been inconsistent. In April 2004, a process for transferring responsibility for commissioning healthcare services in UK prisons to…

Children's Alcohol Initiation: An Analytic Overview

ERIC Educational Resources Information Center

Ward, Bernadette; Snow, Pamela; Aroni, Rosalie

2010-01-01

Many parents support the "supervised introduction" of alcohol to children. While initiation to regular alcohol consumption in early adolescence has been linked with alcohol-related problems in adult life, the findings from these studies cannot be extrapolated to early childhood. The definition of initiation to alcohol in early childhood is often…

Using a Realist Research Methodology in Policy Analysis

ERIC Educational Resources Information Center

Lourie, Megan; Rata, Elizabeth

2017-01-01

The article describes the usefulness of a realist methodology in linking sociological theory to empirically obtained data through the development of a methodological device. Three layers of analysis were integrated: 1. the findings from a case study about Maori language education in New Zealand; 2. the identification and analysis of contradictions…

Getting Closer: Workplace Guidance for Lifelong Learning

ERIC Educational Resources Information Center

Plant, Peter; Turner, Bob

2005-01-01

The purposes of this article are twofold. First, it considers the policy links between guidance and lifelong learning, highlighting in particular the implications of findings from a recent study by the Organisation for Economic Co-operation and Development (OECD). Secondly, it critically compares two approaches to workplace guidance about…

Early Maternal Employment and Children's School Readiness in Contemporary Families

ERIC Educational Resources Information Center

Lombardi, Caitlin McPherran; Coley, Rebekah Levine

2014-01-01

This study assessed whether previous findings linking early maternal employment to lower cognitive and behavioral skills among children generalized to modern families. Using a representative sample of children born in the United States in 2001 (N = 10,100), ordinary least squares regression models weighted with propensity scores assessed links…

Caregivers of School Children with Epilepsy: Findings of a Phenomenological Study

ERIC Educational Resources Information Center

Roberts, Jillian; Whiting, Cheryl

2011-01-01

Epilepsy is one of the most frequently diagnosed neurological disorders among children. Epilepsy is continuously linked with academic underachievement and social challenges. Despite the implications that these difficulties have for a child's educational success, little is known of how children with epilepsy experience school. Understanding how to…

Coping with Relationship Stressors: A Decade Review

ERIC Educational Resources Information Center

Seiffge-Krenke, Inge

2011-01-01

This review identifies key issues in research on adolescent coping with stress with parents, friends, and romantic partners during the past decade. An analysis of 78 studies revealed findings on relationship stressors and the potential links between the use of different coping styles for different relationship types. Research has confirmed…

Urban High School Teachers' Beliefs Concerning Essential Science Teaching Dispositions

ERIC Educational Resources Information Center

Miranda, Rommel

2012-01-01

This qualitative study addresses the link between urban high school science teachers' beliefs about essential teaching dispositions and student learning outcomes. The findings suggest that in order to help students to do well in science in urban school settings, science teachers should possess essential teaching dispositions which include…

Areas of Marital Dissatisfaction among Long-Term Couples

ERIC Educational Resources Information Center

Duba, Jill D.; Hughey, Aaron W.; Lara, Tracy; Burke, Monica G.

2012-01-01

To better understand relational dissatisfaction and duration of long-term married couples, this study surveyed 30 couples married at least 40 years with the Marital Satisfaction Inventory. Findings suggest various areas of dissatisfaction (e.g., affective communication, conflict over child rearing) and relationship among and link to other areas of…

Effects of Differential Family Acculturation on Latino Adolescent Substance Use

ERIC Educational Resources Information Center

Martinez, Charles R., Jr.

2006-01-01

This study examined links between parent-youth differential acculturation and youth substance-use likelihood in a sample of 73 recently immigrated Latino families with middle-school-aged youth. Multiple agents were utilized to assess family functioning and youth outcomes. Findings suggested that a greater level of differential acculturation…

TVDG Home Page

Science.gov Websites

Download WinZip Radiation Effects Testing and Calibration This facility is available for the study of space radiation effects, in particular, Single Event Upset ( SEU ) Testing and Spacecraft Instrument Calibration information about our facility. Visit our Space and Radiation Effects Links page to find out what is going on

Solid-waste management in Jalandhar city and its impact on community health

PubMed Central

Puri, Avinash; Kumar, Manoj; Johal, Eonkar

2008-01-01

In this study, solid-waste management practices were evaluated in order to find out its link with occurrence of vector-borne disease. Strategies for solid-waste management were employed as practical model to solve the problems regarding pollution which is originated by solid-waste. PMID:20040983

Teacher Actions to Facilitate Early Algebraic Reasoning

ERIC Educational Resources Information Center

Hunter, Jodie

2015-01-01

In recent years there has been an increased emphasis on integrating the teaching of arithmetic and algebra in primary school classrooms. This requires teachers to develop links between arithmetic and algebra and use pedagogical actions that facilitate algebraic reasoning. Drawing on findings from a classroom-based study, this paper provides an…

Teachers' Perceptions of Teacher-Child Relationships: Links with Children's Observed Interactions

ERIC Educational Resources Information Center

Hartz, Karyn; Williford, Amanda P.; Koomen, Helma M. Y.

2017-01-01

Research Findings: The present study examined associations between children's classroom interactions and teachers' perceptions of teacher-child relationships during 1 year of preschool. Teachers (n = 223) reported their perceptions of closeness and conflict in their teacher-child relationships in the fall and spring. Children's (n = 895) positive…

Two-phase simulation-based location-allocation optimization of biomass storage distribution

USDA-ARS?s Scientific Manuscript database

This study presents a two-phase simulation-based framework for finding the optimal locations of biomass storage facilities that is a very critical link on the biomass supply chain, which can help to solve biorefinery concerns (e.g. steady supply, uniform feedstock properties, stable feedstock costs,...

A Query Analysis of Consumer Health Information Retrieval

PubMed Central

Hong, Yi; de la Cruz, Norberto; Barnas, Gary; Early, Eileen; Gillis, Rick

2002-01-01

The log files of MCW HealthLink web site were analyzed to study users' needs for consumer health information and get a better understanding of the health topics users are searching for, the paths users usually take to find consumer health information and the way to improve search effectiveness.

''Transformative Pedagogy'' in the Context of Language Teaching: Being and Becoming

ERIC Educational Resources Information Center

Farren, Patrick

2016-01-01

This paper examines, ''transformative pedagogy'' in post-primary, language teacher education in Ireland from philosophical, psychological and social perspectives. Links are made, where appropriate, to findings from a study at the National University of Ireland, Galway, Ireland. The construct supports teacher and pupils in developing their identity…

Gut Microbiota and Autism: Key Concepts and Findings

ERIC Educational Resources Information Center

Ding, Helen T.; Taur, Ying; Walkup, John T.

2017-01-01

There is an emerging body of evidence linking the intestinal microbiota with autism spectrum disorders (ASD). Studies have demonstrated differences in the composition of gut bacteria between children with ASD and controls. Certain intestinal bacteria have been observed in abundance and may be involved in the pathogenesis of ASD; including members…

The Nature of Feedback in English: Teacher Practices

ERIC Educational Resources Information Center

Dargusch, Joanne

2014-01-01

This paper reports on the findings of a study that investigated formative assessment practices of Senior English teachers in the standards-based Queensland assessment system. This paper focuses in particular on the teachers' provision of feedback on rough draft summative assessment items. It identifies the links between assessment criteria and…

Knowledge Retention of Exercise Physiology Content between Athletes and Nonathletes

ERIC Educational Resources Information Center

Clark, Brian; Webster, Collin; Druger, Marvin

2006-01-01

Based on the idea that learning is linked to personal relevance, this study examined knowledge retention of exercise physiology content between college athletes and nonathletes. No differences were observed between the groups. These findings have implications on understanding the relationship between personal relevance and memory. (Contains 1…

Housing Uncertainty and Childhood Impatience

ERIC Educational Resources Information Center

Anil, Bulent; Jordan, Jeffrey L.; Zahirovic-Herbert, Velma

2011-01-01

The study demonstrates a direct link between housing uncertainty and children's time preferences, or patience. We show that students who face housing uncertainties through mortgage foreclosures and eviction learn impatient behavior and are therefore at greater risk of making poor intertemporal choices such as dropping out of school. We find that…

Questioning as a Component of Scaffolding in Predicting Emotion Knowledge in Preschoolers

ERIC Educational Resources Information Center

Bailey, Craig S.; Denham, Susanne A.; Curby, Timothy W.

2013-01-01

The following study expands Denham and Auerbach's (1995, "Mother-child dialogue about emotions and preschoolers' emotional competence." "Genetic, Social, and General Psychology Monographs," 121, 313-337) findings, demonstrating a link between mothers' talk about emotions and preschoolers' knowledge of emotions. We investigate the maternal language…

Father Absence and Adolescent Depression and Delinquency: A Comparison of Siblings Approach

PubMed Central

Markowitz, Anna J.; Ryan, Rebecca M.

2016-01-01

Associations between having a nonresident father and increased internalizing and externalizing behaviors in adolescence have been well established, however, research has yet to establish the plausible causality of these links or identify the mechanisms that may underlie them. Using data from the National Longitudinal Survey of Youth 1979 – the Young Adult survey (CNLSY-YA), the present study addresses these questions by comparing the behavior of siblings discordant for age at father departure across two outcomes, depressive symptoms (N= 5108) and delinquent behavior (N= 4882). Findings indicate that father departure later in childhood is associated with increased delinquency in adolescence but not with greater depressive symptoms. Moreover, father departure in early childhood was not associated with problematic behavior in adolescence. Both findings suggest that parental monitoring rather than disrupted socialization or emotional distress may account for links between having a nonresident father and adolescent delinquency. PMID:27795578

Sexual motivation is reflected by stimulus-dependent motor cortex excitability.

PubMed

Schecklmann, Martin; Engelhardt, Kristina; Konzok, Julian; Rupprecht, Rainer; Greenlee, Mark W; Mokros, Andreas; Langguth, Berthold; Poeppl, Timm B

2015-08-01

Sexual behavior involves motivational processes. Findings from both animal models and neuroimaging in humans suggest that the recruitment of neural motor networks is an integral part of the sexual response. However, no study so far has directly linked sexual motivation to physiologically measurable changes in cerebral motor systems in humans. Using transcranial magnetic stimulation in hetero- and homosexual men, we here show that sexual motivation modulates cortical excitability. More specifically, our results demonstrate that visual sexual stimuli corresponding with one's sexual orientation, compared with non-corresponding visual sexual stimuli, increase the excitability of the motor cortex. The reflection of sexual motivation in motor cortex excitability provides evidence for motor preparation processes in sexual behavior in humans. Moreover, such interrelationship links theoretical models and previous neuroimaging findings of sexual behavior. © The Author (2015). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

Silk fibroin-Thelebolan matrix: A promising chemopreventive scaffold for soft tissue cancer.

PubMed

Mukhopadhyay, Sourav K; Naskar, Deboki; Bhattacharjee, Promita; Mishra, Abheepsa; Kundu, Subhas C; Dey, Satyahari

2017-07-01

Research of improved functional bio-mimetic matrix for regenerative medicine is currently one of the rapidly growing fields in tissue engineering and medical sciences. This study reports a novel bio-polymeric matrix, which is fabricated using silk protein fibroin from Bombyx mori silkworm and fungal exopolysaccharide Thelebolan from Antarctic fungus Thelebolus sp. IITKGP-BT12 by solvent evaporation and freeze drying method. Natural cross linker genipin is used to imprison the Thelebolan within the fibroin network. Different cross-linked and non-cross-linked fibroin/Thelebolan matrices are fabricated and biophysically characterized. Cross-linked thin films show robustness, good mechanical strength and high temperature stability in comparison to non-cross-linked and pure matrices. The 3D sponge matrices demonstrate good cytocompatibility. Interestingly, sustained release of the Thelebolan from the cross-linked matrices induce apoptosis in colon cancer cell line (HT-29) in time dependent manner while it is nontoxic to the normal fibroblast cells (L929).The findings indicate that the cross-linked fibroin/Thelebolan matrices can be used as potential topical chemopreventive scaffold for preclusion of soft tissue carcinoma. Copyright © 2017 Elsevier B.V. All rights reserved.

The "weakest link" as an indicator of cognitive vulnerability differentially predicts symptom dimensions of anxiety in adolescents in China.

PubMed

Wang, Junyi; Wang, Danyang; Cui, Lixia; McWhinnie, Chad M; Wang, Li; Xiao, Jing

2017-08-01

This multiwave longitudinal study examined the cognitive vulnerability-stress component of hopelessness theory to differentially predict symptom dimensions of anxiety using a "weakest link" approach in a sample of adolescents from Hunan Province, China. Baseline and 6-month follow-up data were obtained from 553 middle-school students. During an initial assessment, participants completed measures of assessing their weakest links, anxious symptoms, and the occurrence of stress. Participants subsequently completed measures assessing stress, and anxious symptoms one a month for six months. Higher weakest link scores were associated with greater increases in the harm avoidance and separation anxiety/panic dimensions, but not the physical or social anxiety dimension, of anxious symptoms following stress in Chinese adolescents. These results support the applicability of the "weakest link" approach, derived from hopelessness theory, in Chinese adolescents. Weakest link scores as cognitive vulnerability factors may play a role in the development of anxious symptoms, especially in the cognitive dimensions (e.g., harm avoidance and separation anxiety/panic). Our findings also have potential value in explaining the effectiveness of cognitive relevant therapy in treating the cognitive dimensions of anxious symptoms. Copyright © 2017 Elsevier Ltd. All rights reserved.

Foraging theory predicts predator-prey energy fluxes.

PubMed

Brose, U; Ehnes, R B; Rall, B C; Vucic-Pestic, O; Berlow, E L; Scheu, S

2008-09-01

1. In natural communities, populations are linked by feeding interactions that make up complex food webs. The stability of these complex networks is critically dependent on the distribution of energy fluxes across these feeding links. 2. In laboratory experiments with predatory beetles and spiders, we studied the allometric scaling (body-mass dependence) of metabolism and per capita consumption at the level of predator individuals and per link energy fluxes at the level of feeding links. 3. Despite clear power-law scaling of the metabolic and per capita consumption rates with predator body mass, the per link predation rates on individual prey followed hump-shaped relationships with the predator-prey body mass ratios. These results contrast with the current metabolic paradigm, and find better support in foraging theory. 4. This suggests that per link energy fluxes from prey populations to predator individuals peak at intermediate body mass ratios, and total energy fluxes from prey to predator populations decrease monotonically with predator and prey mass. Surprisingly, contrary to predictions of metabolic models, this suggests that for any prey species, the per link and total energy fluxes to its largest predators are smaller than those to predators of intermediate body size. 5. An integration of metabolic and foraging theory may enable a quantitative and predictive understanding of energy flux distributions in natural food webs.

Parent-Child Interaction, Self-Regulation, and Obesity Prevention in Early Childhood.

PubMed

Anderson, Sarah E; Keim, Sarah A

2016-06-01

This paper describes the epidemiologic evidence linking parent-child relationships, self-regulation, and weight status with a focus on early childhood. The emotional quality of parent-child interactions may influence children's risk for obesity through multiple pathways. Prospective studies linking observer ratings of young children's self-regulation, particularly inhibitory control, to future weight status are discussed. Although findings are preliminary, promoting positive relationships between parents/caregivers and young children holds promise as a component of efforts to prevent childhood obesity. Multi-disciplinary collaborations between researchers with training in developmental science and child health should be encouraged.

Transforming Verbal Counts in Reports of Qualitative Descriptive Studies Into Numbers

PubMed Central

Chang, YunKyung; Voils, Corrine I.; Sandelowski, Margarete; Hasselblad, Vic; Crandell, Jamie L.

2009-01-01

Reports of qualitative studies typically do not offer much information on the numbers of respondents linked to any one finding. This information may be especially useful in reports of basic, or minimally interpretive, qualitative descriptive studies focused on surveying a range of experiences in a target domain, and its lack may limit the ability to synthesize the results of such studies with quantitative results in systematic reviews. Accordingly, the authors illustrate strategies for deriving plausible ranges of respondents expressing a finding in a set of reports of basic qualitative descriptive studies on antiretroviral adherence and suggest how the results might be used. These strategies have limitations and are never appropriate for use with findings from interpretive qualitative studies. Yet they offer a temporary workaround for preserving and maximizing the value of information from basic qualitative descriptive studies for systematic reviews. They show also why quantitizing is never simply quantitative. PMID:19448052

What Can Funders Do to Better Link Science with Decisions? Case Studies of Coastal Communities and Climate Change

NASA Astrophysics Data System (ADS)

Matso, Kalle E.; Becker, Mimi L.

2014-12-01

Many reports and studies have noted that a significant portion of problem-oriented coastal science does not actually link to decisions. Here, three competitively funded project case studies are studied to determine what funders can and should do to better link science with decisions. The qualitative analysis used for this study indicates that the studied program was seen as being unusually attentive to the issue of linking science to decisions, as opposed to simply generating new knowledge. Nevertheless, much of the data indicate that funders can and should do more. Three ideas figured most prominently in the qualitative data: (1) funders should do more to ensure that the problem itself is defined more thoroughly with people who are envisioned as potential users of the science; (2) funders need to allocate more resources and attention to communicating effectively (with users) throughout the project; and (3) funders need to demand more engagement of users throughout the project. These findings have important implications for how funders review and support science, especially when competitive processes are used. Most importantly, funders should adjust what kind of science they ask for. Secondly, funders need to change who is involved in the review process. Currently, review processes focus on knowledge generation, which means that the reviewers themselves have expertise in that area. Instead, review panels should be balanced between those who focus on knowledge generation and those who focus on linking knowledge to decisions; this is a separate but critical discipline currently left out of the review process.

X-linked mental retardation with thin habitus, osteoporosis, and kyphoscoliosis: Linkage to Xp21.3-p22.12

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arena, J.F.; Lubs, H.; Schwartz, C.

We reevaluated a family previously described as having nonspecific X-linked mental retardation (XLMR) by Snyder and Robinson (MINI 309583). Clinical and DNA studies were conducted on 17 relatives, including 6 males with mild-to-moderate mental retardation, 3 carrier females, and 8 normal males. In contrast to the normal appearance and minimal clinical findings reported 22 years ago, affected males were found to have a characteristic set of clinical findings. These developed gradually over the first 2 decades, and included thin body build with diminished muscle mass, osteoporosis and kyphoscoliosis, slight facial asymmetry with a prominent lower lip, nasal speech, high narrowmore » or cleft palate, and long great toes. Carrier females were clinically normal. Multipoint linkage analysis indicated linkage to markers distal to the 3{prime} end of DMD (DXS41 and DXS989), with a maximal lod score of 4.7. On the basis of these findings, this entity is redefined as XLMR syndrome. 22 refs., 6 figs., 2 tabs.« less

The Impact of ABC Canada's LEARN Campaign. Results of a National Research Study.

ERIC Educational Resources Information Center

Long, Ellen

An impact study was conducted of ABC CANADA's LEARN campaign, a national media effort aimed at linking potential literacy learners with literacy groups. Two questionnaires were administered to 94 literacy groups, with 3,557 respondents. Findings included the following: (1) 70 percent of calls to literacy groups were from adult learners aged 16-44;…

Relationships of Attitudes toward Homework and Time Spent on Homework to Course Outcomes: The Case of Foreign Language Learning

ERIC Educational Resources Information Center

Chang, Charles B.; Wall, Daniel; Tare, Medha; Golonka, Ewa; Vatz, Karen

2014-01-01

In previous studies of homework in core academic subjects, positive student attitudes toward homework were linked to higher achievement, whereas time spent on homework showed an inconsistent relationship with achievement. This study examined the generalizability of these findings to foreign language learning by analyzing 2,342 adult students'…

Holistic Sustainability as Key to Emiratization: Links between Job Satisfaction in the Private Sector and Young Emirati Adult Unemployment

ERIC Educational Resources Information Center

Daleure, Georgia M.

2016-01-01

This study examines factors leading to unemployment among young Emirati adults and new entrants to the workforce despite the abundant employment opportunities available in the UAE private sector. The study points out that new entrants to the workforce, including a growing number of college graduates, find few opportunities in the preferred but…

How Fast Do Students Forget What They Learn in Consumer Behavior? A Longitudinal Study

ERIC Educational Resources Information Center

Bacon, Donald R.; Stewart, Kim A.

2006-01-01

The retention curve for knowledge acquired in a consumer behavior course is explored in a longitudinal study, tracking individual students from 8 to 101 weeks following course completion. Rasch measurement is used to link tests and to achieve intervally scaled measures of knowledge. The findings indicate that most of the knowledge gained in the…

Guiding the Design of Lessons by Using the MAPLET Framework: Matching Aims, Processes, Learner Expertise and Technologies

ERIC Educational Resources Information Center

Ifenthaler, Dirk; Gosper, Maree

2014-01-01

This paper introduces the MAPLET framework that was developed to map and link teaching aims, learning processes, learner expertise and technologies. An experimental study with 65 participants is reported to test the effectiveness of the framework as a guide to the design of lessons embedded within larger units of study. The findings indicate the…

"It's Mine!" Does Sharing with Siblings at Age 3 Predict Sharing with Siblings, Friends, and Unfamiliar Peers at Age 6?

ERIC Educational Resources Information Center

White, Naomi; Ensor, Rosie; Marks, Alex; Jacobs, Lorna; Hughes, Claire

2014-01-01

Research Findings: Studies of children's prosocial behavior typically focus on prosocial acts with a specific partner (e.g., a friend, peer, or sibling), and comparisons of prosociality in different contexts are rare. To address this gap, the current study examined predictive links among children's spontaneous sharing (a common and important form…

Linking the Experiential, Affective and Cognitive Domains in Biology Education: A Case Study--Microscopy

ERIC Educational Resources Information Center

Vlaardingerbroek, Barend; Taylor, Neil; Bale, Colin; Kennedy, John

2017-01-01

A greater emphasis in school curricula on the technology of science would encourage teachers to engage their students more in practical work. This in turn might be expected to improve students' attitudes towards science and enhance cognitive outcomes. The paper presents findings from a study on first-year university students' school experience of,…

Researchers Find a Mechanism for Schizophrenia

MedlinePlus

... issue Health Capsule Researchers Find a Mechanism for Schizophrenia En español Send us your comments Scientists uncovered a mechanism behind genetic variations previously linked to schizophrenia. The findings may lead to new clinical approaches. ...

Attachment comes of age: adolescents' narrative coherence and reflective functioning predict well-being in emerging adulthood.

PubMed

Borelli, Jessica L; Brugnera, Agostino; Zarbo, Cristina; Rabboni, Massimo; Bondi, Emi; Tasca, Giorgio A; Compare, Angelo

2018-06-04

This study investigated the effects of adolescents' attachment security and reflective functioning (RF) (assessed by the adult attachment interview [AAI]) in the prediction of well-being in adulthood. Adolescents (N = 79; M = 14.6 years old; SD = 3.5 years) completed the AAI at Time 1 (T1), which was subsequently coded for inferred attachment experiences, narrative coherence, and RF by three nonoverlapping teams of raters. Participants completed the Psychological General Well-being Index at T1 and 8 years later (Time 2, T2). Analyses showed that (a) both adolescent narrative coherence and RF were significant predictors of almost all indices of well-being at T2 in adulthood; (b) both narrative coherence and RF indirectly linked inferred loving parental care and T2 well-being; (c) when included in the same model, RF was a significant indirect effect linking inferred loving parental care and T2 well-being. These findings contribute to theory in suggesting that both RF and narrative coherence are predictive of subsequent psychological well-being and operate as links between inferred parental care and subsequent adjustment. Possible mechanisms underlying these findings are discussed.

Controllability of flow-conservation networks

NASA Astrophysics Data System (ADS)

Zhao, Chen; Zeng, An; Jiang, Rui; Yuan, Zhengzhong; Wang, Wen-Xu

2017-07-01

The ultimate goal of exploring complex networks is to control them. As such, controllability of complex networks has been intensively investigated. Despite recent advances in studying the impact of a network's topology on its controllability, a comprehensive understanding of the synergistic impact of network topology and dynamics on controllability is still lacking. Here, we explore the controllability of flow-conservation networks, trying to identify the minimal number of driver nodes that can guide the network to any desirable state. We develop a method to analyze the controllability on flow-conservation networks based on exact controllability theory, transforming the original analysis on adjacency matrix to Laplacian matrix. With this framework, we systematically investigate the impact of some key factors of networks, including link density, link directionality, and link polarity, on the controllability of these networks. We also obtain the analytical equations by investigating the network's structural properties approximatively and design the efficient tools. Finally, we consider some real networks with flow dynamics, finding that their controllability is significantly different from that predicted by only considering the topology. These findings deepen our understanding of network controllability with flow-conservation dynamics and provide a general framework to incorporate real dynamics in the analysis of network controllability.

Sex differences in associations between spatial ability and corpus callosum morphology.

PubMed

Kurth, Florian; Spencer, Debra; Hines, Melissa; Luders, Eileen

2018-05-10

Rotating mental representations of objects is accompanied by widespread bilateral brain activations. Thus, interhemispheric communication channels may play a relevant part when engaging in mental rotation tasks. Indeed, links between mental rotation and dimensions of the corpus callosum-the brain's main commissure system-have been reported. However, existing findings are sparse and inconsistent across studies. Here we set out to further characterize the nature of any such links, including their exact location across the corpus callosum. For this purpose, we applied an advanced image analysis approach assessing callosal thickness at 100 equidistant points in a sample of 38 healthy adults (19 men, 19 women), aged between 22 and 45 years. We detected a sex interaction, with significant structure-performance relationships in women, but not in men. Specifically, better mental rotation performance was linked to a thicker female corpus callosum within regions of the callosal splenium, posterior midbody, and anterior third. These findings may suggest sex differences in problem solving strategies where in women, more than in men, stronger interhemispheric connectivity-especially between occipitoparietal, frontal, and prefrontal regions-is associated with improved task performance. © 2018 Wiley Periodicals, Inc. © 2018 Wiley Periodicals, Inc.

Predicting missing links and identifying spurious links via likelihood analysis

NASA Astrophysics Data System (ADS)

Pan, Liming; Zhou, Tao; Lü, Linyuan; Hu, Chin-Kun

2016-03-01

Real network data is often incomplete and noisy, where link prediction algorithms and spurious link identification algorithms can be applied. Thus far, it lacks a general method to transform network organizing mechanisms to link prediction algorithms. Here we use an algorithmic framework where a network’s probability is calculated according to a predefined structural Hamiltonian that takes into account the network organizing principles, and a non-observed link is scored by the conditional probability of adding the link to the observed network. Extensive numerical simulations show that the proposed algorithm has remarkably higher accuracy than the state-of-the-art methods in uncovering missing links and identifying spurious links in many complex biological and social networks. Such method also finds applications in exploring the underlying network evolutionary mechanisms.

Predicting missing links and identifying spurious links via likelihood analysis

PubMed Central

Pan, Liming; Zhou, Tao; Lü, Linyuan; Hu, Chin-Kun

2016-01-01

Real network data is often incomplete and noisy, where link prediction algorithms and spurious link identification algorithms can be applied. Thus far, it lacks a general method to transform network organizing mechanisms to link prediction algorithms. Here we use an algorithmic framework where a network’s probability is calculated according to a predefined structural Hamiltonian that takes into account the network organizing principles, and a non-observed link is scored by the conditional probability of adding the link to the observed network. Extensive numerical simulations show that the proposed algorithm has remarkably higher accuracy than the state-of-the-art methods in uncovering missing links and identifying spurious links in many complex biological and social networks. Such method also finds applications in exploring the underlying network evolutionary mechanisms. PMID:26961965

A knowledgebase system to enhance scientific discovery: Telemakus

PubMed Central

Fuller, Sherrilynne S; Revere, Debra; Bugni, Paul F; Martin, George M

2004-01-01

Background With the rapid expansion of scientific research, the ability to effectively find or integrate new domain knowledge in the sciences is proving increasingly difficult. Efforts to improve and speed up scientific discovery are being explored on a number of fronts. However, much of this work is based on traditional search and retrieval approaches and the bibliographic citation presentation format remains unchanged. Methods Case study. Results The Telemakus KnowledgeBase System provides flexible new tools for creating knowledgebases to facilitate retrieval and review of scientific research reports. In formalizing the representation of the research methods and results of scientific reports, Telemakus offers a potential strategy to enhance the scientific discovery process. While other research has demonstrated that aggregating and analyzing research findings across domains augments knowledge discovery, the Telemakus system is unique in combining document surrogates with interactive concept maps of linked relationships across groups of research reports. Conclusion Based on how scientists conduct research and read the literature, the Telemakus KnowledgeBase System brings together three innovations in analyzing, displaying and summarizing research reports across a domain: (1) research report schema, a document surrogate of extracted research methods and findings presented in a consistent and structured schema format which mimics the research process itself and provides a high-level surrogate to facilitate searching and rapid review of retrieved documents; (2) research findings, used to index the documents, allowing searchers to request, for example, research studies which have studied the relationship between neoplasms and vitamin E; and (3) visual exploration interface of linked relationships for interactive querying of research findings across the knowledgebase and graphical displays of what is known as well as, through gaps in the map, what is yet to be tested. The rationale and system architecture are described and plans for the future are discussed. PMID:15507158

Compassionate love as a mechanism linking sacred qualities of marriage to older couples' marital satisfaction.

PubMed

Sabey, Allen K; Rauer, Amy J; Jensen, Jakob F

2014-10-01

Previous work has underscored the robust links between sanctification of marriage and marital outcomes, and recent developments in the literature suggest that compassionate love, which is important for intimate relationships, may act as a mediator of that relationship. Accordingly, the current study used actor-partner interdependence models to examine the relationship between a spiritual cognition (i.e., perceived sacred qualities of marriage) and marital satisfaction, and to determine whether that relationship is mediated by compassionate love, in a sample of older married couples (N = 64). Results revealed that wives' greater sacred qualities of marriage were significantly and positively linked to marital satisfaction on the part of both spouses, and that these links were partially mediated by couples' reports of compassionate love. These findings highlight the importance of moving beyond simply establishing the existence of the link between global markers of involvement of religion and marriage to understanding how specific spiritual cognitions may foster better relationship quality, especially among older couples. (PsycINFO Database Record (c) 2014 APA, all rights reserved).

Watershed and Economic Data InterOperability (WEDO) ...

EPA Pesticide Factsheets

Watershed and Economic Data InterOperability (WEDO) is a system of information technologies designed to publish watershed modeling studies for reuse. WEDO facilitates three aspects of interoperability: discovery, evaluation and integration of data. This increased level of interoperability goes beyond the current practice of publishing modeling studies as reports or journal articles. Rather than summarized results, modeling studies can be published with their full complement of input data, calibration parameters and output with associated metadata for easy duplication by others. Reproducible science is possible only if researchers can find, evaluate and use complete modeling studies performed by other modelers. WEDO greatly increases transparency by making detailed data available to the scientific community.WEDO is a next generation technology, a Web Service linked to the EPA’s EnviroAtlas for discovery of modeling studies nationwide. Streams and rivers are identified using the National Hydrography Dataset network and stream IDs. Streams with modeling studies available are color coded in the EnviroAtlas. One can select streams within a watershed of interest to readily find data available via WEDO. The WEDO website is linked from the EnviroAtlas to provide a thorough review of each modeling study. WEDO currently provides modeled flow and water quality time series, designed for a broad range of watershed and economic models for nutrient trading market analysis. M

Linking public relations processes and organizational effectiveness at a state health department.

PubMed

Wise, Kurt

2003-01-01

This qualitative case study explored a state health department's relationships with strategic constituencies from a public relations perspective. The relationships were explored within the theoretical framework of the Excellence Theory, the dominant paradigm in public research. Findings indicate application of the Excellence Theory has the potential to increase organizational effectiveness at public health entities. With respect to the case investigated, findings indicate that the state health department could increase its organizational effectiveness through the adoption of recommendations based on the Excellence Theory.

Do clients' problem-solving appraisals predict career counseling outcomes or vice versa? A reanalysis of Heppner, et al.

PubMed

Lee, Dong-Gwi; Park, Hyun-Joo; Heppner, Mary J

2009-12-01

Using Heppner, et al.'s data from 2004, this study tested career counseling clients in the United States on problem-solving appraisal scores and career-related variables. A cross-lagged panel design with structural equation modeling was used. Results supported the link between clients' precounseling problem-solving appraisal scores and career outcome. This finding held for career decision-making, but not for vocational identity. The study provided further support for Heppner, et al.'s findings, highlighting the influential role of clients' problem-solving appraisals in advancing their career decision-making processes.

College students' use of communication technology with parents: comparisons between two cohorts in 2009 and 2011.

PubMed

Ramsey, Meagan A; Gentzler, Amy L; Morey, Jennifer N; Oberhauser, Ann M; Westerman, David

2013-10-01

Although communication technology is beneficial to maintain important close relationships, not all findings suggest that communication technology use between college students and their parents is indicative of positive adjustment or relational qualities. A study in 2009 found that only 24.2% of college students used a social networking site (SNS) to communicate with a parent, yet those students reported more loneliness, anxious attachment, and conflict with their parent (Gentzler et al., 2011 ). Because technology and trends in use change rapidly, we investigated a new cohort of college students 2 years later to determine if rates of using communication technology with parents and their links to student adjustment have changed. Comparisons between 2009 and 2011 samples indicated that in-person contact and telephone use did not vary across cohorts. However, texting and SNS use with parents became more common, and using e-mail with parents declined. Consistent with the 2009 data, students' phone use with parents was related to positive relationship qualities (satisfaction, intimacy, support, instrumental aid). In the new 2011 sample, e-mail was linked to aid. However, the present findings indicate students' SNS use with parents is no longer linked to maladaptive outcomes. The study highlights how quickly the use and implications of communication technology changes, and suggests that communication patterns may reflect broader psychosocial adjustment and parent-child dynamics.

Auditory Hallucinations and the Brain’s Resting-State Networks: Findings and Methodological Observations

PubMed Central

Alderson-Day, Ben; Diederen, Kelly; Fernyhough, Charles; Ford, Judith M.; Horga, Guillermo; Margulies, Daniel S.; McCarthy-Jones, Simon; Northoff, Georg; Shine, James M.; Turner, Jessica; van de Ven, Vincent; van Lutterveld, Remko; Waters, Flavie; Jardri, Renaud

2016-01-01

In recent years, there has been increasing interest in the potential for alterations to the brain’s resting-state networks (RSNs) to explain various kinds of psychopathology. RSNs provide an intriguing new explanatory framework for hallucinations, which can occur in different modalities and population groups, but which remain poorly understood. This collaboration from the International Consortium on Hallucination Research (ICHR) reports on the evidence linking resting-state alterations to auditory hallucinations (AH) and provides a critical appraisal of the methodological approaches used in this area. In the report, we describe findings from resting connectivity fMRI in AH (in schizophrenia and nonclinical individuals) and compare them with findings from neurophysiological research, structural MRI, and research on visual hallucinations (VH). In AH, various studies show resting connectivity differences in left-hemisphere auditory and language regions, as well as atypical interaction of the default mode network and RSNs linked to cognitive control and salience. As the latter are also evident in studies of VH, this points to a domain-general mechanism for hallucinations alongside modality-specific changes to RSNs in different sensory regions. However, we also observed high methodological heterogeneity in the current literature, affecting the ability to make clear comparisons between studies. To address this, we provide some methodological recommendations and options for future research on the resting state and hallucinations. PMID:27280452

Determining the Effect of Natural Selection on Linked Neutral Divergence across Species

PubMed Central

Phung, Tanya N.; Lohmueller, Kirk E.

2016-01-01

A major goal in evolutionary biology is to understand how natural selection has shaped patterns of genetic variation across genomes. Studies in a variety of species have shown that neutral genetic diversity (intra-species differences) has been reduced at sites linked to those under direct selection. However, the effect of linked selection on neutral sequence divergence (inter-species differences) remains ambiguous. While empirical studies have reported correlations between divergence and recombination, which is interpreted as evidence for natural selection reducing linked neutral divergence, theory argues otherwise, especially for species that have diverged long ago. Here we address these outstanding issues by examining whether natural selection can affect divergence between both closely and distantly related species. We show that neutral divergence between closely related species (e.g. human-primate) is negatively correlated with functional content and positively correlated with human recombination rate. We also find that neutral divergence between distantly related species (e.g. human-rodent) is negatively correlated with functional content and positively correlated with estimates of background selection from primates. These patterns persist after accounting for the confounding factors of hypermutable CpG sites, GC content, and biased gene conversion. Coalescent models indicate that even when the contribution of ancestral polymorphism to divergence is small, background selection in the ancestral population can still explain a large proportion of the variance in divergence across the genome, generating the observed correlations. Our findings reveal that, contrary to previous intuition, natural selection can indirectly affect linked neutral divergence between both closely and distantly related species. Though we cannot formally exclude the possibility that the direct effects of purifying selection drive some of these patterns, such a scenario would be possible only if more of the genome is under purifying selection than currently believed. Our work has implications for understanding the evolution of genomes and interpreting patterns of genetic variation. PMID:27508305

Determining the Effect of Natural Selection on Linked Neutral Divergence across Species.

PubMed

Phung, Tanya N; Huber, Christian D; Lohmueller, Kirk E

2016-08-01

A major goal in evolutionary biology is to understand how natural selection has shaped patterns of genetic variation across genomes. Studies in a variety of species have shown that neutral genetic diversity (intra-species differences) has been reduced at sites linked to those under direct selection. However, the effect of linked selection on neutral sequence divergence (inter-species differences) remains ambiguous. While empirical studies have reported correlations between divergence and recombination, which is interpreted as evidence for natural selection reducing linked neutral divergence, theory argues otherwise, especially for species that have diverged long ago. Here we address these outstanding issues by examining whether natural selection can affect divergence between both closely and distantly related species. We show that neutral divergence between closely related species (e.g. human-primate) is negatively correlated with functional content and positively correlated with human recombination rate. We also find that neutral divergence between distantly related species (e.g. human-rodent) is negatively correlated with functional content and positively correlated with estimates of background selection from primates. These patterns persist after accounting for the confounding factors of hypermutable CpG sites, GC content, and biased gene conversion. Coalescent models indicate that even when the contribution of ancestral polymorphism to divergence is small, background selection in the ancestral population can still explain a large proportion of the variance in divergence across the genome, generating the observed correlations. Our findings reveal that, contrary to previous intuition, natural selection can indirectly affect linked neutral divergence between both closely and distantly related species. Though we cannot formally exclude the possibility that the direct effects of purifying selection drive some of these patterns, such a scenario would be possible only if more of the genome is under purifying selection than currently believed. Our work has implications for understanding the evolution of genomes and interpreting patterns of genetic variation.

Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach

PubMed Central

Joehanes, Roby; Liu, Chunyu; Aslibekyan, Stella; Demerath, Ellen W.; Guan, Weihua; Zhi, Degui; Willinger, Christine; Courchesne, Paul; Multhaup, Michael; Irvin, Marguerite R.; Schadt, Eric E.; Bressler, Jan; North, Kari; Sundström, Johan; Gustafsson, Stefan; Shah, Sonia; McRae, Allan F.; Harris, Sarah E.; Gibson, Jude; Redmond, Paul; Corley, Janie; Starr, John M.; Visscher, Peter M.; Wray, Naomi R.; Krauss, Ronald M.; Feinberg, Andrew; Fornage, Myriam; Pankow, James S.; Lind, Lars; Fox, Caroline; Ingelsson, Erik; Arnett, Donna K.; Boerwinkle, Eric; Liang, Liming; Levy, Daniel; Deary, Ian J.

2017-01-01

Background The link between DNA methylation, obesity, and adiposity-related diseases in the general population remains uncertain. Methods and Findings We conducted an association study of body mass index (BMI) and differential methylation for over 400,000 CpGs assayed by microarray in whole-blood-derived DNA from 3,743 participants in the Framingham Heart Study and the Lothian Birth Cohorts, with independent replication in three external cohorts of 4,055 participants. We examined variations in whole blood gene expression and conducted Mendelian randomization analyses to investigate the functional and clinical relevance of the findings. We identified novel and previously reported BMI-related differential methylation at 83 CpGs that replicated across cohorts; BMI-related differential methylation was associated with concurrent changes in the expression of genes in lipid metabolism pathways. Genetic instrumental variable analysis of alterations in methylation at one of the 83 replicated CpGs, cg11024682 (intronic to sterol regulatory element binding transcription factor 1 [SREBF1]), demonstrated links to BMI, adiposity-related traits, and coronary artery disease. Independent genetic instruments for expression of SREBF1 supported the findings linking methylation to adiposity and cardiometabolic disease. Methylation at a substantial proportion (16 of 83) of the identified loci was found to be secondary to differences in BMI. However, the cross-sectional nature of the data limits definitive causal determination. Conclusions We present robust associations of BMI with differential DNA methylation at numerous loci in blood cells. BMI-related DNA methylation and gene expression provide mechanistic insights into the relationship between DNA methylation, obesity, and adiposity-related diseases. PMID:28095459

Different Occupations Associated with Amyotrophic Lateral Sclerosis: Is Diesel Exhaust the Link?

PubMed Central

Pamphlett, Roger; Rikard-Bell, Anna

2013-01-01

The cause of sporadic amyotrophic lateral sclerosis (SALS) remains unknown. We attempted to find out if occupational exposure to toxicants plays a part in the pathogenesis of this disease. In an Australia-wide case-control study we compared the lifetime occupations of 611 SALS and 775 control individuals. Occupations were coded using country-specific as well as international classifications. The risk of SALS for each occupation was calculated with odds ratios using logistic regression. In addition, the literature was searched for possible toxicant links between our findings and previously-reported occupational associations with SALS. Male occupations in our study that required lower skills and tasks tended to have increased risks of SALS, and conversely, those occupations that required higher skills and tasks had decreased risks of SALS. Of all the occupations, only truck drivers, where exposure to diesel exhaust is common, maintained an increased risk of SALS throughout all occupational groups. Another large case-control study has also found truck drivers to be at risk of SALS, and almost two-thirds of occupations, as well as military duties, that have previously been associated with SALS have potential exposure to diesel exhaust. In conclusion, two of the largest case-control studies of SALS have now found that truck drivers have an increased risk of SALS. Since exposure to diesel exhaust is common in truck drivers, as well as in other occupations that have been linked to SALS, exposure to this toxicant may underlie some of the occupations that are associated with SALS. PMID:24244728

Linking to NSCEP's Online Publications

EPA Pesticide Factsheets

Each online document has a permanent URL that can be linked to for future reference. To find the short URL for a document you need to be in the document and able to view the icon bar above the document.

The structural role of weak and strong links in a financial market network

NASA Astrophysics Data System (ADS)

Garas, A.; Argyrakis, P.; Havlin, S.

2008-05-01

We investigate the properties of correlation based networks originating from economic complex systems, such as the network of stocks traded at the New York Stock Exchange (NYSE). The weaker links (low correlation) of the system are found to contribute to the overall connectivity of the network significantly more than the strong links (high correlation). We find that nodes connected through strong links form well defined communities. These communities are clustered together in more complex ways compared to the widely used classification according to the economic activity. We find that some companies, such as General Electric (GE), Coca Cola (KO), and others, can be involved in different communities. The communities are found to be quite stable over time. Similar results were obtained by investigating markets completely different in size and properties, such as the Athens Stock Exchange (ASE). The present method may be also useful for other networks generated through correlations.

Analysis of Network Vulnerability Under Joint Node and Link Attacks

NASA Astrophysics Data System (ADS)

Li, Yongcheng; Liu, Shumei; Yu, Yao; Cao, Ting

2018-03-01

The security problem of computer network system is becoming more and more serious. The fundamental reason is that there are security vulnerabilities in the network system. Therefore, it’s very important to identify and reduce or eliminate these vulnerabilities before they are attacked. In this paper, we are interested in joint node and link attacks and propose a vulnerability evaluation method based on the overall connectivity of the network to defense this attack. Especially, we analyze the attack cost problem from the attackers’ perspective. The purpose is to find the set of least costs for joint links and nodes, and their deletion will lead to serious network connection damage. The simulation results show that the vulnerable elements obtained from the proposed method are more suitable for the attacking idea of the malicious persons in joint node and link attack. It is easy to find that the proposed method has more realistic protection significance.

Finding Your Workforce: The Top 25 Institutions Graduating Latinos in Science, Technology, Engineering, and Math (STEM) by Academic Level--2009-10. Third in a Series Linking College Completion with U.S. Workforce Needs

ERIC Educational Resources Information Center

Santiago, Deborah; Soliz, Megan

2012-01-01

Drawing attention to the institutions graduating Latinos in postsecondary education links the college completion goals of the U.S. with the workforce needs of the country. This third brief in the Finding Your Workforce series provides a summary of the top 25 institutions at each academic level graduating Latinos from certificates to doctoral…

Node, Node-Link, and Node-Link-Group Diagrams: An Evaluation.

PubMed

Saket, Bahador; Simonetto, Paolo; Kobourov, Stephen; Börner, Katy

2014-12-01

Effectively showing the relationships between objects in a dataset is one of the main tasks in information visualization. Typically there is a well-defined notion of distance between pairs of objects, and traditional approaches such as principal component analysis or multi-dimensional scaling are used to place the objects as points in 2D space, so that similar objects are close to each other. In another typical setting, the dataset is visualized as a network graph, where related nodes are connected by links. More recently, datasets are also visualized as maps, where in addition to nodes and links, there is an explicit representation of groups and clusters. We consider these three Techniques, characterized by a progressive increase of the amount of encoded information: node diagrams, node-link diagrams and node-link-group diagrams. We assess these three types of diagrams with a controlled experiment that covers nine different tasks falling broadly in three categories: node-based tasks, network-based tasks and group-based tasks. Our findings indicate that adding links, or links and group representations, does not negatively impact performance (time and accuracy) of node-based tasks. Similarly, adding group representations does not negatively impact the performance of network-based tasks. Node-link-group diagrams outperform the others on group-based tasks. These conclusions contradict results in other studies, in similar but subtly different settings. Taken together, however, such results can have significant implications for the design of standard and domain snecific visualizations tools.

Racial/Ethnic Discrimination and Mental Health in Mexican-Origin Youths and Their Parents: Testing the "Linked Lives" Hypothesis.

PubMed

Park, Irene J K; Du, Han; Wang, Lijuan; Williams, David R; Alegría, Margarita

2018-04-01

Using a life course perspective, the present study tested the concept of "linked lives" applied to the problem of not only how racial/ethnic discrimination may be associated with poor mental health for the target of discrimination but also how discrimination may exacerbate the discrimination-distress link for others in the target's social network-in this case, the family. The discrimination-distress link was investigated among 269 Mexican-origin adolescents and their parents both cross-sectionally and longitudinally. It was hypothesized that parents' discrimination experiences would adversely affect their adolescent children's mental health via a moderating effect on the target adolescent discrimination-distress link. The converse was also hypothesized for the target parents. Multilevel moderation analyses were conducted to test the moderating effect of parents' discrimination experiences on the youth discrimination-distress link. We also tested the moderating effect of youths' discrimination experiences on the parent discrimination-distress link. Parents' discrimination experiences significantly moderated the longitudinal association between youths' discrimination stress appraisals and mental health, such that the father's discrimination experiences exacerbated the youth discrimination-depression link. Youths' discrimination stress appraisals were not a significant moderator of the cross-sectional parent discrimination-mental health association. Implications of these findings are discussed from a linked lives perspective, highlighting how fathers' discrimination experiences can adversely affect youths who are coping with discrimination, in terms of their mental health. Copyright © 2017 The Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

Bias in the Flesh: Skin Complexion and Stereotype Consistency in Political Campaigns.

PubMed

Messing, Solomon; Jabon, Maria; Plaut, Ethan

2016-01-01

There is strong evidence linking skin complexion to negative stereotypes and adverse real-world outcomes. We extend these findings to political ad campaigns, in which skin complexion can be easily manipulated in ways that are difficult to detect. Devising a method to measure how dark a candidate appears in an image, this paper examines how complexion varied with ad content during the 2008 presidential election campaign (study 1). Findings show that darker images were more frequent in negative ads-especially those linking Obama to crime-which aired more frequently as Election Day approached. We then conduct an experiment to document how these darker images can activate stereotypes, and show that a subtle darkness manipulation is sufficient to activate the most negative stereotypes about Blacks-even when the candidate is a famous counter-stereotypical exemplar-Barack Obama (study 2). Further evidence of an evaluative penalty for darker skin comes from an observational study measuring affective responses to depictions of Obama with varying skin complexion, presented via the Affect Misattribution Procedure in the 2008 American National Election Study (study 3). This study demonstrates that darker images are used in a way that complements ad content, and shows that doing so can negatively affect how individuals evaluate candidates and think about politics.

Impression management and achievement motivation: Investigating substantive links.

PubMed

Elliot, Andrew J; Aldhobaiban, Nawal; Murayama, Kou; Kobeisy, Ahmed; Gocłowska, Małgorzata A; Khyat, Aber

2018-02-01

In this research, we investigate impression management (IM) as a substantive personality variable by linking it to differentiated achievement motivation constructs, namely achievement motives (workmastery, competitiveness, fear of failure) and achievement goals (mastery-approach, mastery-avoidance, performance-approach, performance-avoidance). Study 1 revealed that IM was a positive predictor of workmastery and a negative predictor of competitiveness (with and without self-deceptive enhancement (SDE) controlled). Studies 2a and 2b revealed that IM was a positive predictor of mastery-approach goals and mastery-avoidance goals (without and, in Study 2b, with SDE controlled). These findings highlight the value of conceptualising and utilising IM as a personality variable in its own right and shed light on the nature of the achievement motive and achievement goal constructs. © 2016 International Union of Psychological Science.

Links Between Contexts and Middle to Late Childhood Social-Emotional Development.

PubMed

Duong, Jeffrey; Bradshaw, Catherine P

2017-12-01

Guided by the social-emotional learning (SEL) framework, we studied developmental trajectory patterns of five key competency outcomes spanning middle through late childhood: altruism, empathy, self-efficacy, aggression, and hyperactivity. We then assessed their links to middle childhood home, parental, and community contexts. Data from the Institute of Education Sciences' Social and Character Development Program, which comprised nearly 2,400 elementary school students who were followed from Grades 3 through 5, were analyzed using growth mixture modeling. Three trajectory groups emerged for each outcome, which were linked to childhood contexts. Positive parenting was associated with a lower likelihood of following a negative empathy trajectory among children. Neighborhood intergenerational closure promoted a stable self-efficacy trajectory. Residing in a high-risk community was linked to increasing normative beliefs about aggression. These findings suggest an important role of contexts in influencing childhood social-emotional development in the later elementary school years. © Society for Community Research and Action 2017.

Roles of Communication Problems and Communication Strategies on Resident-Related Role Demand and Role Satisfaction.

PubMed

Savundranayagam, Marie Y; Lee, Christopher

2017-03-01

This study investigated the impact of dementia-related communication difficulties and communication strategies used by staff on resident-related indicators of role demand and role satisfaction. Formal/paid long-term care staff caregivers (N = 109) of residents with dementia completed questionnaires on dementia-related communication difficulties, communication strategies, role demand (ie, residents make unreasonable demands), and role satisfaction (measured by relationship closeness and influence over residents). Three types of communication strategies were included: (a) effective repair strategies, (b) completing actions by oneself, and (c) tuning out or ignoring the resident. Analyses using structural equation modeling revealed that communication problems were positively linked with role demand. Repair strategies were positively linked with relationship closeness and influence over residents. Completing actions by oneself was positively linked to role demand and influence over residents, whereas tuning out was negatively linked with influence over residents. The findings underscore that effective caregiver communication skills are essential in enhancing staff-resident relationships.

Negative reactions to monitoring: Do they undermine the ability of monitoring to protect adolescents?

PubMed

Laird, Robert D; Zeringue, Megan M; Lambert, Emily S

2018-02-01

This study focused on adolescents' negative reactions to parental monitoring to determine whether parents should avoid excessive monitoring because adolescents find monitoring behaviors to be over-controlling and privacy invasive. Adolescents (n = 242, M age = 15.4 years; 51% female) reported monitoring, negative reactions, warmth, antisocial behavior, depressive symptoms, and disclosure. Adolescents additionally reported antisocial behavior, depressive symptoms, and disclosure one to two years later. In cross-sectional analyses, less monitoring but more negative reactions were linked with less disclosure, suggesting that negative reactions can undermine parents' ability to obtain information. Although monitoring behaviors were not related to depressive symptoms, more negative reactions were linked with more depressive symptoms, suggesting that negative reactions also may increase depressive symptoms as a side effect of monitoring behavior. Negative reactions were not linked to antisocial behavior. There were no longitudinal links between negative reactions and changes in disclosure, antisocial behavior, or depressive symptoms. Copyright © 2017. Published by Elsevier Ltd.

Pathways linking parental divorce with adolescent depression.

PubMed

Aseltine, R H

1996-06-01

This article examines the intervening pathways linking parental divorce with adolescent depression, using both cross-sectional and prospective data from a study of high school students in the Boston metropolitan area. Overall, findings reveal that parental divorce is linked with adolescent depression in two ways: (1) it is a source of numerous secondary problems and stresses that are causally related to depression, and (2) it alters youths' reactivity to these stresses, in some cases enhancing, but in other cases mitigating, their depressive effects. Analyses demonstrated the central role of economic hardship in linking family status with depression, with the strength of this indirect pathway partly attributable to the greater vulnerability of youths in single-parent families to financial stresses. In contrast, family conflict did not account for the distress of youths in single-parent families, largely because of their immunity to the effects of such conflict. Finally, prospective data failed to support the hypothesis that differences between youths in single-parent and intact families predate the divorce.

How People Interact in Evolving Online Affiliation Networks

NASA Astrophysics Data System (ADS)

Gallos, Lazaros K.; Rybski, Diego; Liljeros, Fredrik; Havlin, Shlomo; Makse, Hernán A.

2012-07-01

The study of human interactions is of central importance for understanding the behavior of individuals, groups, and societies. Here, we observe the formation and evolution of networks by monitoring the addition of all new links, and we analyze quantitatively the tendencies used to create ties in these evolving online affiliation networks. We show that an accurate estimation of these probabilistic tendencies can be achieved only by following the time evolution of the network. Inferences about the reason for the existence of links using statistical analysis of network snapshots must therefore be made with great caution. Here, we start by characterizing every single link when the tie was established in the network. This information allows us to describe the probabilistic tendencies of tie formation and extract meaningful sociological conclusions. We also find significant differences in behavioral traits in the social tendencies among individuals according to their degree of activity, gender, age, popularity, and other attributes. For instance, in the particular data sets analyzed here, we find that women reciprocate connections 3 times as much as men and that this difference increases with age. Men tend to connect with the most popular people more often than women do, across all ages. On the other hand, triangular tie tendencies are similar, independent of gender, and show an increase with age. These results require further validation in other social settings. Our findings can be useful to build models of realistic social network structures and to discover the underlying laws that govern establishment of ties in evolving social networks.

Musical Preferences are Linked to Cognitive Styles.

PubMed

Greenberg, David M; Baron-Cohen, Simon; Stillwell, David J; Kosinski, Michal; Rentfrow, Peter J

2015-01-01

Why do we like the music we do? Research has shown that musical preferences and personality are linked, yet little is known about other influences on preferences such as cognitive styles. To address this gap, we investigated how individual differences in musical preferences are explained by the empathizing-systemizing (E-S) theory. Study 1 examined the links between empathy and musical preferences across four samples. By reporting their preferential reactions to musical stimuli, samples 1 and 2 (Ns = 2,178 and 891) indicated their preferences for music from 26 different genres, and samples 3 and 4 (Ns = 747 and 320) indicated their preferences for music from only a single genre (rock or jazz). Results across samples showed that empathy levels are linked to preferences even within genres and account for significant proportions of variance in preferences over and above personality traits for various music-preference dimensions. Study 2 (N = 353) replicated and extended these findings by investigating how musical preferences are differentiated by E-S cognitive styles (i.e., 'brain types'). Those who are type E (bias towards empathizing) preferred music on the Mellow dimension (R&B/soul, adult contemporary, soft rock genres) compared to type S (bias towards systemizing) who preferred music on the Intense dimension (punk, heavy metal, and hard rock). Analyses of fine-grained psychological and sonic attributes in the music revealed that type E individuals preferred music that featured low arousal (gentle, warm, and sensual attributes), negative valence (depressing and sad), and emotional depth (poetic, relaxing, and thoughtful), while type S preferred music that featured high arousal (strong, tense, and thrilling), and aspects of positive valence (animated) and cerebral depth (complexity). The application of these findings for clinicians, interventions, and those on the autism spectrum (largely type S or extreme type S) are discussed.

Musical Preferences are Linked to Cognitive Styles

PubMed Central

Greenberg, David M.; Baron-Cohen, Simon; Stillwell, David J.; Kosinski, Michal; Rentfrow, Peter J.

2015-01-01

Why do we like the music we do? Research has shown that musical preferences and personality are linked, yet little is known about other influences on preferences such as cognitive styles. To address this gap, we investigated how individual differences in musical preferences are explained by the empathizing-systemizing (E-S) theory. Study 1 examined the links between empathy and musical preferences across four samples. By reporting their preferential reactions to musical stimuli, samples 1 and 2 (Ns = 2,178 and 891) indicated their preferences for music from 26 different genres, and samples 3 and 4 (Ns = 747 and 320) indicated their preferences for music from only a single genre (rock or jazz). Results across samples showed that empathy levels are linked to preferences even within genres and account for significant proportions of variance in preferences over and above personality traits for various music-preference dimensions. Study 2 (N = 353) replicated and extended these findings by investigating how musical preferences are differentiated by E-S cognitive styles (i.e., ‘brain types’). Those who are type E (bias towards empathizing) preferred music on the Mellow dimension (R&B/soul, adult contemporary, soft rock genres) compared to type S (bias towards systemizing) who preferred music on the Intense dimension (punk, heavy metal, and hard rock). Analyses of fine-grained psychological and sonic attributes in the music revealed that type E individuals preferred music that featured low arousal (gentle, warm, and sensual attributes), negative valence (depressing and sad), and emotional depth (poetic, relaxing, and thoughtful), while type S preferred music that featured high arousal (strong, tense, and thrilling), and aspects of positive valence (animated) and cerebral depth (complexity). The application of these findings for clinicians, interventions, and those on the autism spectrum (largely type S or extreme type S) are discussed. PMID:26200656

DNA methylation changes at infertility genes in newborn twins conceived by in vitro fertilisation.

PubMed

Castillo-Fernandez, Juan E; Loke, Yuk Jing; Bass-Stringer, Sebastian; Gao, Fei; Xia, Yudong; Wu, Honglong; Lu, Hanlin; Liu, Yuan; Wang, Jun; Spector, Tim D; Saffery, Richard; Craig, Jeffrey M; Bell, Jordana T

2017-03-24

The association of in vitro fertilisation (IVF) and DNA methylation has been studied predominantly at regulatory regions of imprinted genes and at just thousands of the ~28 million CpG sites in the human genome. We investigated the links between IVF and DNA methylation patterns in whole cord blood cells (n = 98) and cord blood mononuclear cells (n = 82) from newborn twins using genome-wide methylated DNA immunoprecipitation coupled with deep sequencing. At a false discovery rate (FDR) of 5%, we identified one significant whole blood DNA methylation change linked to conception via IVF, which was located ~3 kb upstream of TNP1, a gene previously linked to male infertility. The 46 most strongly associated signals (FDR of 25%) included a second region in a gene also previously linked to infertility, C9orf3, suggesting that our findings may in part capture the effect of parental subfertility. Using twin modelling, we observed that individual-specific environmental factors appear to be the main overall contributors of methylation variability at the FDR 25% IVF-associated differentially methylated regions, although evidence for methylation heritability was also obtained at several of these regions. We replicated previous findings of differential methylation associated with IVF at the H19/IGF2 region in cord blood mononuclear cells, and we validated the signal at C9orf3 in monozygotic twins. We also explored the impact of intracytoplasmic sperm injection on the FDR 25% signals for potential effects specific to male or female infertility factors. To our knowledge, this is the most comprehensive study of DNA methylation profiles at birth and IVF conception to date, and our results show evidence for epigenetic modifications that may in part reflect parental subfertility.

Generalist Genes: Genetic Links between Brain, Mind, and Education

ERIC Educational Resources Information Center

Plomin, Robert; Kovas, Yulia; Haworth, Claire M. A.

2007-01-01

Genetics contributes importantly to learning abilities and disabilities--not just to reading, the target of most genetic research, but also to mathematics and other academic areas as well. One of the most important recent findings from quantitative genetic research such as twin studies is that the same set of genes is largely responsible for…

Childlessness, Parenthood, and Depressive Symptoms among Middle-Aged and Older Adults

ERIC Educational Resources Information Center

Bures, Regina M.; Koropeckyj-Cox, Tanya; Loree, Michael

2009-01-01

Prior research has examined whether parenthood is associated with higher levels of well-being among older adults, but definitions of parental status have varied. The authors examine links between parental status and depressive symptoms among older adults, comparing biological and social definitions of parenthood. The study finds few differences…

The Benefits of Frequent Positive Affect: Does Happiness Lead to Success?

ERIC Educational Resources Information Center

Lyubomirsky, Sonja; King, Laura; Diener, Ed

2005-01-01

Numerous studies show that happy individuals are successful across multiple life domains, including marriage, friendship, income, work performance, and health. The authors suggest a conceptual model to account for these findings, arguing that the happiness-success link exists not only because success makes people happy, but also because positive…

Urban Middle-School Teachers' Beliefs about Astronomy Learner Characteristics: Implications for Curriculum

ERIC Educational Resources Information Center

Miranda, Rommel J.

2010-01-01

This study addresses the link between urban teachers' beliefs about their students' ability to succeed in astronomy and their instructional decisions and practices in response to those beliefs. The findings suggest that teachers believe that the student characteristics that are necessary for high achievement in astronomy include specific cognitive…

Literacy in ESL: Pedagogical and Cultural Pathfinding in Fiji.

ERIC Educational Resources Information Center

Lotherington-Woloszyn, Heather

Although English is a colonial heritage in Fiji, it links the country's different ethnic groups and is the language of instruction for formal education. This paper examines pedagogical and cultural implications of the present primary English curriculum, based on findings from an empirical study of primary English teaching in Fiji. It reviews the…

Online Activities, Digital Media Literacy, and Networked Individualism of Korean Youth

ERIC Educational Resources Information Center

Park, Sora; Kim, Eun-mee; Na, Eun-Yeong

2015-01-01

Networked individualism enables Internet users to connect and socialize via their loose and transient multiple networks, whereas digital media literacy is a precondition of effective Internet use. In this study, an attempt has been made to find the link between networked individualism, digital media literacy, and young people's perception of their…

Exploring the Relationship between Reading and Writing in Early Literacy Development.

ERIC Educational Resources Information Center

Kurth, Ruth J.

Researchers studying emerging literacy have begun building a theory of literacy development that links the processes of reading and writing. Their findings suggest that a child's emerging literacy is based on three factors: a functional expectation for print to make logical sense; an expectation of how language operates in alternate contexts; and…

Temperament Dimensions in Preschool Children: Links with Cognitive and Affective Theory of Mind

ERIC Educational Resources Information Center

Longobardi, Emiddia; Spataro, Pietro; D'Alessandro, Marta; Cerutti, Rita

2017-01-01

Research Findings: The present cross-sectional study investigated the question of whether 6 different temperament dimensions (inhibition to novelty, social orientation, motor activity, positive emotionality, negative emotionality, and attention) influenced cognitive and affective theory of mind (ToM) in 168 children (86 three/four-year-olds and 82…

Untangling the Complex Needs of People Experiencing Gambling Problems and Homelessness

ERIC Educational Resources Information Center

Holdsworth, Louise; Tiyce, Margaret

2013-01-01

People with gambling problems are now recognised among those at increased risk of homelessness, and the link between housing and gambling problems has been identified as an area requiring further research. This paper discusses the findings of a qualitative study that explored the relationship between gambling problems and homelessness. Interviews…

Romantic Attachment and Relationship Functioning in Same-Sex Couples

ERIC Educational Resources Information Center

Mohr, Jonathan J.; Selterman, Dylan; Fassinger, Ruth E.

2013-01-01

The present study was designed to investigate links between dimensions of romantic attachment and relationship functioning in a cross-sectional sample of people in same-sex relationships, with the goals of replicating basic findings from research on heterosexual couples and advancing understanding of unique issues faced by same-sex couples. The…

Resident Fathers' Pregnancy Intentions, Prenatal Behaviors, and Links to Involvement with Infants

ERIC Educational Resources Information Center

Bronte-Tinkew, Jacinta; Ryan, Suzanne; Carrano, Jennifer; Moore, Kristen A.

2007-01-01

Using data from the Early Childhood Longitudinal Study-Birth Cohort, 9-month resident father surveys (N= 6,816), this paper examines the association between male pregnancy intentions, prenatal behaviors, and postbirth father involvement. Findings indicate that prenatal behaviors are associated with five domains of father involvement. Men who did…

Evidence of Intercultural Communication Competence in Tenth Grader's Narrative Texts

ERIC Educational Resources Information Center

Guerrero Moya, María Eulalia; Muñoz Ortiz, Liliana; Niño Díaz, Ana María

2016-01-01

This action research study explored the effects of an intervention linking both culture and citizenship in a tenth-grade English language class, and aimed at finding evidence of intercultural communicative competence (ICC) skills through the writing of narrative texts in English. Participants were 75 tenth-grade students, between the ages of 14…

The Relationship between Reciprocity and the Emotional and Behavioural Responses of Staff

ERIC Educational Resources Information Center

Thomas, Cathryn; Rose, John

2010-01-01

Background: The current study examines a model relating to the concept of reciprocity and burnout in staff, incorporating previous research findings based upon Weiner's (1980, 1986) cognitive-emotional model linking emotions, optimism and helping behaviour, with the aim of testing the model. Materials: Staff working in community homes within the…

Educational Change: A Case for a "Pedagogy of Compassion"

ERIC Educational Resources Information Center

Vandeyar, Saloshna; Swart, Ronel

2016-01-01

This paper sets out to advance the concept of an "epistemology of compassion" first proposed by Vandeyar (2013; 2016). Utilising a single embedded case study and the theoretical mooring of post-conflict pedagogy this paper attempts to find links between Jansen's perceptions of a post-conflict pedagogy and Freirean pedagogy and to argue a…

Quality of Care Attributions to Employed Versus Stay-at-Home Mothers

ERIC Educational Resources Information Center

Shpancer, Noam; Melick, Katherine M.; Sayre, Pamela S.; Spivey, Aria T.

2006-01-01

The present study was designed to find whether evaluations of maternal competence are linked to mothers' employment status and the quality of maternal care. Participants rated videotaped vignettes, depicting either high-quality or low-quality mother-infant interactions, on various dimensions of care quality. The videotaped mothers were described…

Does Maternal Employment Following Childbirth Support or Inhibit Low-Income Children's Long-Term Development?

ERIC Educational Resources Information Center

Coley, Rebekah Levine; Lombardi, Caitlin McPherran

2013-01-01

This study assessed whether previous findings linking early maternal employment to lower cognitive and behavioral skills among middle-class and White children generalized to other groups. Using a representative sample of urban, low-income, predominantly African American and Hispanic families ("n" = 444), ordinary least squares regression…

Partnering Principal and Teacher Candidates: Exploring a Virtual Coaching Model in Teacher Education

ERIC Educational Resources Information Center

Stapleton, Joy; Tschida, Christina; Cuthrell, Kristen

2017-01-01

Colleges of education are constantly searching for innovations to develop stronger graduates. This paper describes and shares findings from a study of a virtual coaching partnership model that links a principal candidate with a teacher candidate. Through the use of existing virtual coaching software, this model provides teacher candidates with…

The Attention Skills and Academic Performance of Aggressive/Rejected and Low Aggressive/Popular Children

ERIC Educational Resources Information Center

Wilson, Beverly J.; Petaja, Holly; Mancil, Larissa

2011-01-01

Research Findings: Aggressive/rejected children are at risk for continuing conduct and school problems. Some limited research indicates that these children have attention problems. Previous research has linked attention problems with academic performance. The current study investigated group differences in attention skills and the role of these…

Opinions about Child Corporal Punishment and Influencing Factors

ERIC Educational Resources Information Center

Bell, Tessa; Romano, Elisa

2012-01-01

The use of corporal punishment has been linked to negative developmental outcomes for children. Despite this finding, Section 43 of the Canadian Criminal Code permits the use of corporal punishment by parents for children 2 to 12 years of age. Therefore, this study's first objective is to investigate opinions toward Section 43 and spanking more…

Using thermography to detect misalignment in coupled equipment

NASA Astrophysics Data System (ADS)

Kelch, Craig K.; Grover, Paul E.

1996-03-01

This paper describes and reports the findings of a study performed by the Miller Brewing Company. The researchers assembled a test bed consisting of a motor and generator linked by seven different interchangeable flexible couplings. They then misaligned the motor and generator and used different predictive technologies to monitor any coupling changes.

Captured by Motion: Dance, Action Understanding, and Social Cognition

ERIC Educational Resources Information Center

Sevdalis, Vassilis; Keller, Peter E.

2011-01-01

In this review article, we summarize the main findings from empirical studies that used dance-related forms of rhythmical full body movement as a research tool for investigating action understanding and social cognition. This work has proven to be informative about behavioral and brain mechanisms that mediate links between perceptual and motor…

Self-Regulation Mediates the Link between Family Context and Socioemotional Competence in Turkish Preschoolers

ERIC Educational Resources Information Center

Gündüz, Gizem; Yagmurlu, Bilge; Harma, Mehmet

2015-01-01

Research Findings: In this study, we examined self-regulatory skills, namely, effortful control and executive function, in Turkish preschoolers (N = 217) and their mediating roles in the associations between parenting and children's socioemotional competence. We also investigated the role of family socioeconomic status and maternal psychological…

What College and University Websites Reveal about the Purposes of Higher Education

ERIC Educational Resources Information Center

Saichaie, Kem; Morphew, Christopher C.

2014-01-01

College and university websites play an important role in the college search process. This study examines the textual and visual elements on the websites of 12 colleges and universities. Findings suggest that websites communicate a message consistent with private purposes of education and inconsistent with those linked to public purposes.

Linking Implementation Fidelity to Impacts in an RCT

ERIC Educational Resources Information Center

Unlu, Fatih; Bozzi, Laurie; Layzer, Carolyn; Smith, Arthur; Price, Cristofer; Hurtig, Richard

2013-01-01

In experimental studies, researchers are often interested in secondary research questions that explore important aspects of main findings, such as whether or not program effects vary according to the level of fidelity in which the program has been implemented; or according to the dosage received by individuals participated in the program. In this…

Assessing Adolescents' Communicative Self-Efficacy to Discuss Controversial Issues: Findings from a Randomized Study of the Word Generation Program

ERIC Educational Resources Information Center

Lin, Alex R.; Lawrence, Joshua F.; Snow, Catherine E.; Taylor, Karen S.

2016-01-01

Communicative self-efficacy serves as an important link between discussing controversial issues and civic engagement because confidence in one's discourse skills is important to managing conflicting perspectives and developing solutions to community-based problems. Freely available to schools, "Word Generation" is a cross-content…

Human activity and the spread of Phytophthora ramorum

Treesearch

Hall J. Cushman; Michelle Cooper; Ross K. Meentemeyer; Shelly Benson

2008-01-01

Increasing numbers of studies are finding that humans can facilitate the spread of exotic plant species in protected wildlands. Hiking trails commonly serve as conduits for invaders and the number of exotic plant species occurring in protected areas is often correlated positively with visitation rates. Despite such evidence linking human activity to the spread of...

Exploring Zimbabwean Advanced Level Chemistry Students' Approaches to Investigations from a Learning Perspective

ERIC Educational Resources Information Center

Chirikure, Tamirirofa; Hobden, Paul; Hobden, Sally

2018-01-01

In this paper we report on the findings of a study on Advanced Level Chemistry students' approaches to investigations from a learning perspective in the Zimbabwean educational context. Students' approaches to investigations are inextricably linked to the quality of learning and performances in these practical activities. An explanatory…

The Relevance of a Migration Background to the Professional Identity of Teachers

ERIC Educational Resources Information Center

Bressler, Christoph; Rotter, Carolin

2017-01-01

Immigrant teachers face several specific expectations from policy makers, colleagues, as well as the media. Often new hopes are pinned on them for teaching (ethnically) diverse learners. Their professional identity is inevitably linked to these expectations. In this regard, this paper discusses the findings of a qualitative study exploring the…

Intergenerational Transfers of Preferences for Science Careers in Comparative Perspective

ERIC Educational Resources Information Center

Sikora, Joanna; Pokropek, Artur

2012-01-01

Using data from 24 countries, which participated in the 2006 Programme for International Student Assessment (PISA), we examine the relationship between parental science employment and students' career expectations. In contrast to prior PISA-based studies, we find that the link between parental employment and adolescent plans to work in science is…

Democracy and Education, Schools and Communities Initiative: Conceptual Framework and Preliminary Findings.

ERIC Educational Resources Information Center

Koliba, Christopher

Nine rural Vermont schools committed to linking to their local communities are participating in an ongoing study of how manifest curricula (what is taught) and latent curricula (how classes are taught and schools are governed) influence development of student dispositions toward democratic participation. This paper presents preliminary findings…

Gender Differences in Perceptions of Sexual Intent: A Qualitative Review and Integration

ERIC Educational Resources Information Center

Lindgren, Kristen P.; Parkhill, Michele R.; George, William H.; Hendershot, Christian S.

2008-01-01

Men appear to interpret people's behaviors more sexually than do women. This finding, which has been replicated in scores of studies using a variety of methodological approaches, has been linked to important social concerns, including sexual assault and sexual harassment. This article provides a critical review of the published literature on…

Youth Emancipating from Foster Care in California: Findings Using Linked Administrative Data.

ERIC Educational Resources Information Center

Needell, Barbara; Cuccaro-Alamin, Stephanie; Brookhart, Alan; Jackman, William; Shlonsky, Aron

This study examined characteristics of youth emancipated from child welfare (ECW) and probation (EPR) supervised foster care; receipt of mental health services for emancipating youth; births to emancipating females; deaths of youth who emancipated from foster care; receipt of Medi-Cal due to AFDC/TANF, SSI/disability, or medical indigence after…

Planned approaches to business and school partnerships. Does it make a difference? The business perspective.

PubMed

Lee, Kerry; Hope, John; Abdulghani, Fatima

2016-04-01

In many countries, schools are encouraged to link with business to add authenticity to learning. The number of these business-school partnerships has shown a marked increase over the last twenty years. Traditionally researchers investigating these partnerships have focussed on the schools' perspectives (Du, Bhattacharya, & Sen, 2010, pp. 32-33), however this New Zealand research has focused solely on the business perspective of established school partnerships. The study used a mixed methods approach utilising both online survey and semi-structured interviews. Ten out of the forty participating businesses surveyed used a brokering organisation as a way of developing and maintaining these partnerships and some developed rationales to support the partnership. This study investigated the value of using brokering organisations, rationales and designated staff to support business-school partnerships. Findings indicate that brokers and designated staff play a very effective role in enhancing business-school links, and more benefits are perceived when a rationale has been established. It is anticipated that these findings will support the development and success of business-school partnerships. Copyright © 2015 Elsevier Ltd. All rights reserved.

Psychedelics not linked to mental health problems or suicidal behavior: a population study.

PubMed

Johansen, Pål-Ørjan; Krebs, Teri Suzanne

2015-03-01

A recent large population study of 130,000 adults in the United States failed to find evidence for a link between psychedelic use (lysergic acid diethylamide, psilocybin or mescaline) and mental health problems. Using a new data set consisting of 135,095 randomly selected United States adults, including 19,299 psychedelic users, we examine the associations between psychedelic use and mental health. After adjusting for sociodemographics, other drug use and childhood depression, we found no significant associations between lifetime use of psychedelics and increased likelihood of past year serious psychological distress, mental health treatment, suicidal thoughts, suicidal plans and suicide attempt, depression and anxiety. We failed to find evidence that psychedelic use is an independent risk factor for mental health problems. Psychedelics are not known to harm the brain or other body organs or to cause addiction or compulsive use; serious adverse events involving psychedelics are extremely rare. Overall, it is difficult to see how prohibition of psychedelics can be justified as a public health measure. © The Author(s) 2015.

Emotion Regulation Feeding Practices Link Parents' Emotional Eating to Children's Emotional Eating: A Moderated Mediation Study.

PubMed

Tan, Cin Cin; Holub, Shayla C

2015-08-01

Past research suggests an association between parents' and children's emotional eating, but research has yet to examine mechanisms underlying this association. The current study examined whether feeding for emotion regulation mediates the association between parents' and children's emotional eating, and whether this association is moderated by children's self-regulation in eating. 95 parents reported on their own and their children's emotional eating, their children's self-regulation in eating, as well as their feeding practices. Findings revealed that feeding for emotion regulation mediated the association between parents' and children's emotional eating when children's self-regulation in eating was low, but not when self-regulation in eating was high. The current findings demonstrate the complexity of the link between parents' and children's emotional eating, suggesting practitioners should consider both feeding practices and children's self-regulation in eating when designing intervention programs. © The Author 2015. Published by Oxford University Press on behalf of the Society of Pediatric Psychology. All rights reserved.For permissions, please e-mail: journals.permissions@oup.com.

Sexual Risk-Taking in HIV-Negative Gay and Bisexual Men Increases with Depression: Results from a U.S. National Study

PubMed Central

Millar, Brett M.; Starks, Tyrel J.; Grov, Christian; Parsons, Jeffrey T.

2017-01-01

The link between depression and sexual risk-taking has received mixed findings in the literature. The current study analyzed the links between depression and recent condomless anal sex (CAS) with casual partners among 1033 HIV-negative, non-PrEP-using, gay and bisexual men. When CAS was dichotomized as either none or some, depression was not associated with the odds of CAS (with receptive and insertive combined) or insertive CAS only, but was positively associated with the odds of receptive CAS. When CAS was tallied as a count variable of events, depression was positively associated with total CAS, receptive CAS, and insertive CAS. With the addition of a quadratic term for depression, a positive quadratic effect was only found for total CAS and receptive CAS, but not for insertive CAS. These findings highlight the utility of using count data for CAS events and treating CAS separately with regard to receptive and insertive positioning when considering the role of depression among gay and bisexual men. PMID:27475943

Theory of mind in children with and without autism spectrum disorder: Associations with the sibling constellation.

PubMed

Matthews, Nicole L; Goldberg, Wendy A

2018-04-01

The two prior studies that have examined associations between the sibling constellation and theory of mind in autism spectrum disorder yielded discrepant findings. Thus, efforts to better understand the sibling-theory of mind link in autism spectrum disorder are necessary. This study examined a sample of prekindergarten- and kindergarten-aged (i.e. 4-6 years) typically developing children ( n = 39) and verbal children with autism spectrum disorder ( n = 61). Sibling presence, number of siblings, and having younger and older siblings were positively associated with theory of mind in typically developing children, but not in the full sample of children with autism spectrum disorder. However, in the subgroup of children with autism spectrum disorder without sibling recurrence, the presence of at least one older sibling was positively associated with theory of mind. Findings expand previous limited research on the sibling-theory of mind link in children with autism spectrum disorder by demonstrating a potential difference in the influence of the sibling constellation between children from simplex and multiplex families.

Testing bidirectional effects between cannabis use and depressive symptoms: moderation by the serotonin transporter gene.

PubMed

Otten, Roy; Engels, Rutger C M E

2013-09-01

Evidence for the assumption that cannabis use is associated with depression and depressive symptoms is inconsistent and mostly weak. It is likely that the mixed results are due to the fact that prior studies ignored the moderating effects of an individual's genetic vulnerability. The present study takes a first step in scrutinizing the relationship between cannabis use and depressive symptoms by taking a developmental molecular-genetic perspective. Specifically, we concentrated on changes in cannabis use and depressive symptoms over time in a simultaneous manner and differences herein for individuals with and without the short allele of the 5-hydroxytryptamine (serotonin) transporter gene-linked polymorphic region (5-HTTLPR) genotype. Data were from 310 adolescents over a period of 4 years. We used a parallel-process growth model, which allows co-development of cannabis use and depressive symptoms throughout adolescence, and the possible role of the 5-HTTLPR genotype in this process. We used data from the younger siblings of these adolescents in an attempt to replicate potential findings. The parallel-process growth model shows that cannabis use increases the risk for an increase in depressive symptoms over time but only in the presence of the short allele of the 5-HTTLPR genotype. This effect remained significant after controlling for covariates. We did not find conclusive support for the idea that depressive symptoms affect cannabis use. These findings were replicated in the sample of the younger siblings. The findings of the present study show first evidence that the links between cannabis use and depressive symptoms are conditional on the individual's genetic makeup. © 2011 The Authors, Addiction Biology © 2011 Society for the Study of Addiction.

Relationship between cancer-related traumatic stress and family milestone achievement in adolescent and young adult survivors of childhood cancer.

PubMed

Tillery, Rachel; Beal, Sarah J; Thompson, Aimee N; Pai, Ahna L H

2018-06-01

Late physical and emotional effects of cancer treatment pose a burden for adolescent and young adult survivors of childhood cancer, including family milestone achievement. This brief report examined links between ongoing cancer-related post-traumatic stress symptoms (CR-PTSS) and family milestone achievement. Survivors (n = 51; M age  = 24.73, SD = 8.20) completed CR-PTSS and family formation questionnaires. Descriptive statistics, univariate parameter-constraints, and correlation analyses examined relations among study variables. Ongoing intrusive thoughts and hyperarousal were negatively linked to family identity development and family achievement. Findings from the present study provide support that ongoing CR-PTSS may be a barrier to family formation. © 2018 Wiley Periodicals, Inc.

Proximity Begins with a Smile, But Which One? Associating Non-duchenne Smiles with Higher Psychological Distance

PubMed Central

Bogodistov, Yevgen; Dost, Florian

2017-01-01

This study reveals that Duchenne (genuine) and non-Duchenne (non-genuine, polite) smiles are implicitly associated with psychological proximity and distance, respectively. These findings link two extensive research streams from human communication and psychology. Interestingly, extant construal-level theory research suggests the link may work as smiles signaling either a benign situation or politeness, resulting in conflicting predictions for the association between smile type and psychological distance. The current study uses implicit association tests to reveal theoretically and empirically consistent non-Duchenne-smile–distance and Duchenne-smile–proximity associations for all four types of psychological distance: temporal, spatial, social, and hypothetical. Practically, the results suggest several useful applications of non-Duchenne smiles in human communication contexts. PMID:28848483

Who's the Boss? Patterns of Control in Adolescents' Sibling Relationships.

PubMed

Tucker, Corinna Jenkins; Updegraff, Kimberly A; Baril, Megan E

2010-12-01

The goals of this study were to examine longitudinal changes in perceived control in adolescents' sibling relationships and to describe the nature and correlates of three distinct control patterns: Firstborn dominant, equal, and secondborn dominant. Firstborn and secondborn adolescents in 184 predominately European-American families participated in home interviews and a series of phone interviews as part of a longitudinal a study of family relationships and adolescent development. Findings revealed changes in control over three years as well as sibling differences. In addition, different patterns of control were linked to qualities of the sibling relationship and to adolescent adjustment. The different roles that firstborn and secondborn siblings assume, and why these roles are linked to relationship experiences and adjustment, are discussed.

Who’s the Boss? Patterns of Control in Adolescents’ Sibling Relationships

PubMed Central

Tucker, Corinna Jenkins; Updegraff, Kimberly A.; Baril, Megan E.

2011-01-01

The goals of this study were to examine longitudinal changes in perceived control in adolescents’ sibling relationships and to describe the nature and correlates of three distinct control patterns: Firstborn dominant, equal, and secondborn dominant. Firstborn and secondborn adolescents in 184 predominately European-American families participated in home interviews and a series of phone interviews as part of a longitudinal a study of family relationships and adolescent development. Findings revealed changes in control over three years as well as sibling differences. In addition, different patterns of control were linked to qualities of the sibling relationship and to adolescent adjustment. The different roles that firstborn and secondborn siblings assume, and why these roles are linked to relationship experiences and adjustment, are discussed. PMID:21857761

Effects of adaptive dynamical linking in networked games

NASA Astrophysics Data System (ADS)

Yang, Zhihu; Li, Zhi; Wu, Te; Wang, Long

2013-10-01

The role of dynamical topologies in the evolution of cooperation has received considerable attention, as some studies have demonstrated that dynamical networks are much better than static networks in terms of boosting cooperation. Here we study a dynamical model of evolution of cooperation on stochastic dynamical networks in which there are no permanent partners to each agent. Whenever a new link is created, its duration is randomly assigned without any bias or preference. We allow the agent to adaptively adjust the duration of each link during the evolution in accordance with the feedback from game interactions. By Monte Carlo simulations, we find that cooperation can be remarkably promoted by this adaptive dynamical linking mechanism both for the game of pairwise interactions, such as the Prisoner's Dilemma game (PDG), and for the game of group interactions, illustrated by the public goods game (PGG). And the faster the adjusting rate, the more successful the evolution of cooperation. We also show that in this context weak selection favors cooperation much more than strong selection does. What is particularly meaningful is that the prosperity of cooperation in this study indicates that the rationality and selfishness of a single agent in adjusting social ties can lead to the progress of altruism of the whole population.

Robustness of spatial micronetworks

NASA Astrophysics Data System (ADS)

McAndrew, Thomas C.; Danforth, Christopher M.; Bagrow, James P.

2015-04-01

Power lines, roadways, pipelines, and other physical infrastructure are critical to modern society. These structures may be viewed as spatial networks where geographic distances play a role in the functionality and construction cost of links. Traditionally, studies of network robustness have primarily considered the connectedness of large, random networks. Yet for spatial infrastructure, physical distances must also play a role in network robustness. Understanding the robustness of small spatial networks is particularly important with the increasing interest in microgrids, i.e., small-area distributed power grids that are well suited to using renewable energy resources. We study the random failures of links in small networks where functionality depends on both spatial distance and topological connectedness. By introducing a percolation model where the failure of each link is proportional to its spatial length, we find that when failures depend on spatial distances, networks are more fragile than expected. Accounting for spatial effects in both construction and robustness is important for designing efficient microgrids and other network infrastructure.

Cascading effects of interparental conflict in adolescence: Linking threat appraisals, self-efficacy, and adjustment.

PubMed

Fosco, Gregory M; Feinberg, Mark E

2015-02-01

This study examined the longitudinal implications of adolescents' exposure to interparental conflict for their developmental success. In the proposed developmental cascade model, adolescents' perceptions of parental conflict as threatening is a risk factor for diminished self-efficacy, which would account for diminished adjustment. This study presents longitudinal data for 768 sixth-grade students and their families over four time points, ending in eighth grade. Analyses were conducted in three steps. First, replication of longitudinal support for threat as a mediator of the link between interparental conflict and emotional distress was found; however, findings did not support threat as a mediator of behavior problems or subjective well-being. Second, threat was found to mediate the longitudinal association between interparental conflict and self-efficacy. Third, a developmental cascade model supported a risk process in which interparental conflict was related to adolescents' threat appraisals, which undermined self-efficacy beliefs, and was then linked with emotional distress, behavior problems, and subjective well-being.

Social Capital and Unretirement: Exploring the Bonding, Bridging, and Linking Aspects of Social Relationships.

PubMed

Gonzales, Ernest; Nowell, W Benjamin

2017-12-01

Working longer is an important area of research given extended life expectancy, shortfalls of retirement income, desires to remain socially engaged, and solvency concerns of social insurance programs. The purpose of this longitudinal population-based study of older adults is to examine how different types of social resources (social bonding, bridging, and linking) relate to returning to work after retirement. Data were drawn from the Health and Retirement Study of fully retired older adults aged 62+ in 1998 ( N = 8,334) and followed to 2008. After controlling for a comprehensive set of fixed and time-varying covariates, findings suggest that social bridging (informal volunteering) and social linking (formal volunteering, partnered with an employed spouse) were strongly and positively related to returning to work (Hazard Ratio [HR]: 1.49, p < .001; HR: 1.58, p < .0001; and HR: 1.75, p < .0001, respectively). Social bonding resources were not significantly associated with returning to work. Implications for social policy are discussed.

"I just feel so guilty": The role of introjected regulation in linking appearance goals for exercise with women's body image.

PubMed

Hurst, Megan; Dittmar, Helga; Banerjee, Robin; Bond, Rod

2017-03-01

Appearance goals for exercise are consistently associated with negative body image, but research has yet to consider the processes that link these two variables. Self-determination theory offers one such process: introjected (guilt-based) regulation of exercise behavior. Study 1 investigated these relationships within a cross-sectional sample of female UK students (n=215, 17-30 years). Appearance goals were indirectly, negatively associated with body image due to links with introjected regulation. Study 2 experimentally tested this pathway, manipulating guilt relating to exercise and appearance goals independently and assessing post-test guilt and body anxiety (n=165, 18-27 years). The guilt manipulation significantly increased post-test feelings of guilt, and these increases were associated with increased post-test body anxiety, but only for participants in the guilt condition. The implications of these findings for self-determination theory and the importance of guilt for the body image literature are discussed. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Controlling Hysteresis in Superconducting Weak Links and μ-Superconducting Quantum Interference Devices

NASA Astrophysics Data System (ADS)

Kumar, Nikhil; Winkelmann, C. B.; Biswas, Sourav; Courtois, H.; Gupta, Anjan K.

We have fabricated and studied the current-voltage characteristics of a number of niobium film based weak-link devices and μ-SQUIDs showing a critical current and two re-trapping currents. We have proposed a new understanding for the re-trapping currents in terms of thermal instabilities in different portions of the device. We also find that the superconducting proximity effect and the phase-slip processes play an important role in dictating the temperature dependence of the critical current in the non-hysteretic regime. The proximity effect helps in widening the temperature range of hysteresis-free characteristics. Finally we demonstrate control on temperature-range with hysteresis-free characteristics in two ways: 1) By using a parallel shunt resistor in close vicinity of the device, and 2) by reducing the weak-link width. Thus we get non-hysteretic behavior down to 1.3 K temperature in some of the studied devices. We acknowledge the financial support from CSIR, India as well as CNRS-Institute Neel, Grenoble, France.

Cascading Effects of Interparental Conflict in Adolescence: Linking Threat Appraisals, Self-Efficacy, and Adjustment

PubMed Central

Fosco, Gregory M.; Feinberg, Mark E.

2015-01-01

This study examined the longitudinal implications of adolescents’ exposure to interparental conflict for their developmental success. In the proposed developmental cascade model, adolescents’ perceptions of parental conflict as threatening is a risk factor for diminished self-efficacy, which would account for diminished adjustment. This study presents longitudinal data for 768 6th-grade students and their families over four time points, ending in 8th grade. Analyses were conducted in three steps. First, replication of longitudinal support for threat as a mediator of the link between interparental conflict and emotional distress was found; however, findings did not support threat as a mediator of behavior problems or subjective well-being. Second, threat was found to mediate the longitudinal association between interparental conflict and self-efficacy. Finally, a developmental cascade model supported a risk process in which interparental conflict was related to adolescents’ threat appraisals, which undermined self-efficacy beliefs, and was then linked with emotional distress, behavior problems, and subjective well-being. PMID:25017469

The moderating role of ethnicity in the relation between religiousness and mental health among ethnically diverse college students.

PubMed

Cokley, Kevin; Garcia, Daniel; Hall-Clark, Brittany; Tran, Kimberly; Rangel, Azucena

2012-09-01

Many studies have documented the links between dimensions of religiousness with mental health (e.g., Hackney and Sanders 2003; Mofidi et al. 2006). However, very little is known about whether these links differ across ethnic groups. This study examined the contribution of dimensions of religiousness to the prediction of mental health in an ethnically diverse sample of 413 college students (167 European Americans, 83 African Americans, 81 Asian Americans, and 82 Latino Americans). Results indicated significant ethnic differences across dimensions of religiousness. African Americans were significantly higher on religious engagement and religious conservatism than the other ethnic groups and significantly lower on religious struggle than European Americans. Moderated multiple regressions revealed that increases in religious struggle was associated with poorer mental health for African Americans and Latino Americans, while increases in religious engagement and ecumenical worldview were associated with better mental health for African Americans. The findings indicate that ethnicity is an important factor to consider when examining the link between religiousness and mental health.

Association between pornography use and sexual risk behaviors in adult consumers: a systematic review.

PubMed

Harkness, Emily L; Mullan, Barbara; Mullan, Barbara M; Blaszczynski, Alex

2015-02-01

The purpose of this review was to determine whether an association exists between sexual risk behaviors and pornography consumption. Consumption of pornography is common, yet research examining its link with sexual risk behaviors is in its infancy. Indicators of sexual risk behavior, including unsafe sex practices and a higher number of sexual partners, have been linked to poor health outcomes. A systematic literature search was performed using Medline, PsycINFO, Web of Knowledge, Pubmed, and CINAHL. Studies were included if they assessed the association between pornography use and indicators of sexual risk behaviors in an adult population. A total of 17 were included in the review, and all were assessed for research standards using the Quality Index Scale. For both Internet pornography and general pornography, links with greater unsafe sex practices and number of sexual partners were identified. Limitations of the literature, including low external validity and poor study design, restrict the generalizability of the findings. Accordingly, replication and more rigorous methods are recommended for future research.

Maternal education and child nutritional status in Bolivia: finding the links.

PubMed

Frost, Michelle Bellessa; Forste, Renata; Haas, David W

2005-01-01

This study models various pathways linking maternal education and child nutritional status in Bolivia, using a national sample of children. Pathways examined include socioeconomic status, health knowledge, modern attitudes towards health care, female autonomy, and reproductive behavior. The data come from the 1998 Bolivia Demographic and Health Survey. Logistic regression results suggest that socioeconomic factors are the most important pathways linking maternal education and child nutritional status, and that modern attitudes about health care also explain the impact of education. Health care knowledge accounts for less of the effect of maternal education on child nutritional status, with autonomy being the weakest pathway. Other pathways, such as reproductive behaviors, appear to influence nutritional status independent of maternal education. Overall, the pathways examined accounted for 60 percent of the effect of maternal education on child nutritional status.

Effects of enterprise technology on supply chain collaboration: analysis of China-linked supply chain

NASA Astrophysics Data System (ADS)

Li, Ling

2012-02-01

Supply chain collaboration has received increasing attention from scholars and practitioners in recent years. However, our understanding of how enterprise information technology facilitates supply chain collaboration is still very limited, especially with regard to Chinese enterprise ownerships such as state-owned firms, joint-venture firms and local village-owned firms. This paper extends the theory established in enterprise information technology (IT) and supply chain collaboration literature and relates it with coordination in China-linked supply chain. Drawing upon an empirical study from 177 Chinese companies, we provide three major findings: (i) uncovered the importance of leveraging enterprise IT through supply chain collaboration; (ii) identified the relationship between enterprise ownership and enterprise technology use and supply chain collaboration in China-linked supply chain and (iii) illustrated effects of supply chain collaborative activities on operational and market performance.

Correction and Use of Biomedical Literature Affected by Scientific Misconduct

PubMed Central

Neale, Anne Victoria; Northrup, Justin; Dailey, Rhonda; Marks, Ellen; Abrams, Judith

2009-01-01

The purpose of this study was to identify and describe published research articles that were named in official findings of scientific misconduct and to investigate compliance with the administrative actions contained in these reports for corrections and retractions, as represented in PubMed. Between 1993 and 2001, 102 articles were named in either the NIH Guide for Grants and Contracts (“Findings of Scientific Misconduct”) or the U.S. Office of Research Integrity annual reports as needing retraction or correction. In 2002, 98 of the 102 articles were indexed in PubMed. Eighty-five of these 98 articles had indexed corrections: 47 were retracted; 26 had an erratum; 12 had a correction described in the “comment” field. Thirteen had no correction, but 10 were linked to the NIH Guide “Findings of Scientific Misconduct”, leaving only 3 articles with no indication of any sort of problem. As of May 2005, there were 5,393 citations to the 102 articles, with a median of 26 citations per article (range 0–592). Researchers should be alert to “Comments” linked to the NIH Guide as these are open access, and the “Findings of Scientific Misconduct’ reports are often more informative than the statements about the retraction or correction found in the journals. PMID:17703606

Joint genetic analysis of hippocampal size in mouse and human identifies a novel gene linked to neurodegenerative disease.

PubMed

Ashbrook, David G; Williams, Robert W; Lu, Lu; Stein, Jason L; Hibar, Derrek P; Nichols, Thomas E; Medland, Sarah E; Thompson, Paul M; Hager, Reinmar

2014-10-03

Variation in hippocampal volume has been linked to significant differences in memory, behavior, and cognition among individuals. To identify genetic variants underlying such differences and associated disease phenotypes, multinational consortia such as ENIGMA have used large magnetic resonance imaging (MRI) data sets in human GWAS studies. In addition, mapping studies in mouse model systems have identified genetic variants for brain structure variation with great power. A key challenge is to understand how genetically based differences in brain structure lead to the propensity to develop specific neurological disorders. We combine the largest human GWAS of brain structure with the largest mammalian model system, the BXD recombinant inbred mouse population, to identify novel genetic targets influencing brain structure variation that are linked to increased risk for neurological disorders. We first use a novel cross-species, comparative analysis using mouse and human genetic data to identify a candidate gene, MGST3, associated with adult hippocampus size in both systems. We then establish the coregulation and function of this gene in a comprehensive systems-analysis. We find that MGST3 is associated with hippocampus size and is linked to a group of neurodegenerative disorders, such as Alzheimer's.

Should academic journals publish e-cigarette research linked to tobacco companies?

PubMed

Shaw, David M; Etter, Jean-François; Elger, Bernice S

2016-08-01

Electronic cigarettes are currently polarizing professional opinion. Some public health experts regard them as an effective smoking cessation aid and a vital means of reducing active and passive smoking, while others regard them as another attempt by the tobacco industry to create new customers and addicts. These different attitudes unsurprisingly yield different conclusions regarding both the appropriate regulation of e-cigarettes and the ethical status of research funded by, or conducted in, cooperation with the tobacco industry. This paper examines whether e-cigarette research linked to the tobacco industry should be regarded as an exception to the rule that tobacco industry research is so tainted by conflicts of interest that journals should refuse to publish them, or at the very least treat them as a special case for scrutiny. Despite the fact that e-cigarettes can be used for smoking cessation, most of the conflicts of interest that apply to other tobacco research also apply to e-cigarette research linked to that industry. Journals that currently refuse to publish findings from studies linked to tobacco companies have no reason to make an exception in the case of e-cigarettes. © 2015 Society for the Study of Addiction.

Immunoglobulin Heavy Chain Variable Region and Major Histocompatibility Region Genes Are Linked to Induced Graves' Disease in Females From Two Very Large Families of Recombinant Inbred Mice

PubMed Central

Aliesky, Holly; Banuelos, Bianca; Magana, Jessica; Williams, Robert W.; Rapoport, Basil

2014-01-01

Graves' hyperthyroidism is caused by antibodies to the TSH receptor (TSHR) that mimic thyroid stimulation by TSH. Stimulating TSHR antibodies and hyperthyroidism can be induced by immunizing mice with adenovirus expressing the human TSHR A-subunit. Prior analysis of induced Graves' disease in small families of recombinant inbred (RI) female mice demonstrated strong genetic control but did not resolve trait loci for TSHR antibodies or elevated serum T4. We investigated the genetic basis for induced Graves' disease in female mice of two large RI families and combined data with earlier findings to provide phenotypes for 178 genotypes. TSHR antibodies measured by inhibition of TSH binding to its receptor were highly significantly linked in the BXD set to the major histocompatibility region (chromosome 17), consistent with observations in 3 other RI families. In the LXS family, we detected linkage between T4 levels after TSHR-adenovirus immunization and the Ig heavy chain variable region (Igvh, chromosome 12). This observation is a key finding because components of the antigen binding region of Igs determine antibody specificity and have been previously linked to induced thyroid-stimulating antibodies. Data from the LXS family provide the first evidence in mice of a direct link between induced hyperthyroidism and Igvh genes. A role for major histocompatibility genes has now been established for genetic susceptibility to Graves' disease in both humans and mice. Future studies using arrays incorporating variation in the complex human Ig gene locus will be necessary to determine whether Igvh genes are also linked to Graves' disease in humans. PMID:25051451

Transactions within the family: Coparenting mediates associations between parents' relationship satisfaction and the parent-child relationship.

PubMed

Peltz, Jack S; Rogge, Ronald D; Sturge-Apple, Melissa L

2018-06-21

In the current study, we examined the potential for transactional relations among parents' marital satisfaction, coparental cooperation and conflict, and parent-child relationship satisfaction in a sample of 249 families with 2-3-year-old children. Using a novel multiwave design with frequent assessments to better capture transactional family processes, mothers and fathers were assessed across 5 waves with 2-month lags; mean age of the target children (53% girls) was 2.8 years ( SD = 0.62) at baseline. Cross-lagged, multilevel structural equation modeling (SEM) analyses using an actor-partner interdependence modeling framework revealed coparental cooperation and conflict as likely mechanisms within the family system. Specifically, marital satisfaction from both parents was reciprocally linked to fathers' coparental cooperation over time, supporting transactional links between those two family subsystems. In addition, there were significant transactional links between both mothers' and fathers' coparental cooperation and father-reported parent-child relationship satisfaction across time, revealing within-parent and cross-parent mediation. Regarding coparental conflict, marital satisfaction from both parents was reciprocally linked to the same parents' reports of coparental conflict across time (i.e., actor effects). Furthermore, father-reported coparental conflict acted as a mediating or intervening mechanism between father-reported marital satisfaction and mother-reported parent-child relationship satisfaction (cross-parent mediation). Taken as a set, the findings supported coparental cooperation and conflict as significant links between marital functioning and the parent-child relationship. Findings build on a growing body of literature addressing the transactional associations embedded within the family system and highlight the importance of modeling the inherent interdependencies between mothers' and fathers' reports of family functioning. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Difficult but Close Relationships: Children's Perspectives on Relationships With Their Mothers in the Context of Domestic Violence.

PubMed

Lapierre, Simon; Côté, Isabelle; Lambert, Amélie; Buetti, David; Lavergne, Chantal; Damant, Dominique; Couturier, Vanessa

2018-07-01

This article reports findings from a participative and qualitative study conducted with children who had experienced domestic violence, focusing on their perspectives on their relationships with their mothers. Three focus groups and 46 individual interviews were conducted with children to gather their experiences. The research findings demonstrate that women's and children's victimizations are inextricably linked, and that domestic violence affects mother-child relationships. They also show that, despite the challenges and difficulties, children generally consider their mothers as very significant individuals in their lives, and have close relationships with them. The findings also reveal a dynamic of mutual protectiveness.

Reliving emotional personal memories: affective biases linked to personality and sex-related differences.

PubMed

Denkova, Ekaterina; Dolcos, Sanda; Dolcos, Florin

2012-06-01

Although available evidence suggests that the emotional valence and recollective properties of autobiographical memories (AMs) may be influenced by personality- and sex-related differences, overall these relationships remain poorly understood. The present study investigated these issues by comparing the effect of general personality traits (extraversion and neuroticism) and specific traits linked to emotion regulation (ER) strategies (reappraisal and suppression) on the retrieval of emotional AMs and on the associated postretrieval emotional states, in men and women. First, extraversion predicted recollection of positive AMs in both men and women, whereas neuroticism predicted the proportion of negative AMs in men and the frequency of rehearsing negative AMs in women. Second, reappraisal predicted positive AMs in men, and suppression predicted negative AMs in women. Third, while reliving of positive memories had an overall indirect effect on postretrieval positive mood through extraversion, reliving of negative AMs had a direct effect on postretrieval negative mood, which was linked to inefficient engagement of suppression in women. Our findings suggest that personality traits associated with positive affect predict recollection of positive AMs and maintenance of a positive mood, whereas personality traits associated with negative affect, along with differential engagement of habitual ER strategies in men and women, predict sex-related differences in the recollection and experiencing of negative AMs. These findings provide insight into the factors that influence affective biases in reliving AMs, and into their possible link to sex-related differences in the susceptibility to affective disorders.

Motor and sensory neuropathy due to myelin infolding and paranodal damage in a transgenic mouse model of Charcot–Marie–Tooth disease type 1C

PubMed Central

Lee, Samuel M.; Sha, Di; Mohammed, Anum A.; Asress, Seneshaw; Glass, Jonathan D.; Chin, Lih-Shen; Li, Lian

2013-01-01

Charcot–Marie–Tooth disease type 1C (CMT1C) is a dominantly inherited motor and sensory neuropathy. Despite human genetic evidence linking missense mutations in SIMPLE to CMT1C, the in vivo role of CMT1C-linked SIMPLE mutations remains undetermined. To investigate the molecular mechanism underlying CMT1C pathogenesis, we generated transgenic mice expressing either wild-type or CMT1C-linked W116G human SIMPLE. Mice expressing mutant, but not wild type, SIMPLE develop a late-onset motor and sensory neuropathy that recapitulates key clinical features of CMT1C disease. SIMPLE mutant mice exhibit motor and sensory behavioral impairments accompanied by decreased motor and sensory nerve conduction velocity and reduced compound muscle action potential amplitude. This neuropathy phenotype is associated with focally infolded myelin loops that protrude into the axons at paranodal regions and near Schmidt–Lanterman incisures of peripheral nerves. We find that myelin infolding is often linked to constricted axons with signs of impaired axonal transport and to paranodal defects and abnormal organization of the node of Ranvier. Our findings support that SIMPLE mutation disrupts myelin homeostasis and causes peripheral neuropathy via a combination of toxic gain-of-function and dominant-negative mechanisms. The results from this study suggest that myelin infolding and paranodal damage may represent pathogenic precursors preceding demyelination and axonal degeneration in CMT1C patients. PMID:23359569

The Role of B Vitamins in Preventing and Treating Cognitive Impairment and Decline123

PubMed Central

Morris, Martha Savaria

2012-01-01

Many epidemiologic studies have considered whether markers of B-vitamin status are associated with cognitive function and cognitive decline. This avenue of research was sparked by the homocysteine (Hcy) theory of cardiovascular disease, which was extended to Alzheimer’s disease when a link between vascular dementia and Alzheimer’s disease was discovered. Hcy could cause cognitive impairment via direct neurotoxicity. However, decreased remethylation of Hcy to methionine might also compromise cognitive function by means other than mere Hcy lowering. Folate and vitamin B-12 participate in Hcy remethylation and largely determine Hcy status. Consequently, much of the relevant research has focused on these 2 B vitamins. The many subtly different hypotheses that investigators have addressed by attempting to link several B-vitamin status indicators to diverse cognition-related outcomes have created a confusing body of conflicting studies that seems to defy summarization. Nevertheless, themes are discernible that aid interpretation, foster hypothesis generation, and inform future study design. For example, despite a shared metabolic pathway, Hcy, vitamin B-12, and folate are differently related to specific cognitive outcomes. Although consistency of findings across studies is often touted as essential to distinguishing causal from coincidental relationships, discrepancies among study findings can be even more informative. PMID:23153734

Dependency, democracy, and infant mortality: a quantitative, cross-national analysis of less developed countries.

PubMed

Shandra, John M; Nobles, Jenna; London, Bruce; Williamson, John B

2004-07-01

This study presents quantitative, sociological models designed to account for cross-national variation in infant mortality rates. We consider variables linked to four different theoretical perspectives: the economic modernization, social modernization, political modernization, and dependency perspectives. The study is based on a panel regression analysis of a sample of 59 developing countries. Our preliminary analysis based on additive models replicates prior studies to the extent that we find that indicators linked to economic and social modernization have beneficial effects on infant mortality. We also find support for hypotheses derived from the dependency perspective suggesting that multinational corporate penetration fosters higher levels of infant mortality. Subsequent analysis incorporating interaction effects suggest that the level of political democracy conditions the effects of dependency relationships based upon exports, investments from multinational corporations, and international lending institutions. Transnational economic linkages associated with exports, multinational corporations, and international lending institutions adversely affect infant mortality more strongly at lower levels of democracy than at higher levels of democracy: intranational, political factors interact with the international, economic forces to affect infant mortality. We conclude with some brief policy recommendations and suggestions for the direction of future research.

The link between sensation seeking and aggression: a meta-analytic review.

PubMed

Wilson, Laura C; Scarpa, Angela

2011-01-01

Substantial empirical evidence supports low resting heart rate (HR) as the best replicated psychophysiological correlate of aggression [Ortiz and Raine, 2004]; however, researchers continue to debate the explanatory mechanisms of the phenomenon. Sensation seeking has been proposed as a possible outcome of low resting HR that may lead to aggressive tendencies but findings have been inconsistent in terms of showing a relationship between sensation seeking and aggression. A meta-analysis was conducted on 43 independent effect sizes, from studies with a total of 32,217 participants, to test the hypothesis that sensation seeking would be positively related to aggression across studies. A significant overall effect size was found (d = .1935, P<.001), supporting the hypothesis. Moderator analyses revealed that the relationship differed based on participant and methodological characteristics, such as participant age and the nature of the aggression measurement; however, these conclusions are limited by the uneven number of studies in many of the moderator classes. Overall, the findings provide support for higher levels of aggression in high sensation seekers and have theoretical implications for arousal theory. Further research on the links between arousal, sensation seeking and aggression can inform clinicians about potential interventions. © 2010 Wiley-Liss, Inc.

The Link Between Nutrition and Physical Activity in Increasing Academic Achievement.

PubMed

Asigbee, Fiona M; Whitney, Stephen D; Peterson, Catherine E

2018-06-01

Research demonstrates a link between decreased cognitive function in overweight school-aged children and improved cognitive function among students with high fitness levels and children engaging in regular physical activity (PA). The purpose of this study was to examine whether regular PA and proper nutrition together had a significant effect on academic achievement. Using the seventh wave of the Early Childhood Longitudinal Study, Kindergarten Class 1998-99 (ECLS-K) dataset, linear regression analysis with a Jackknife resampling correction was conducted to analyze the relationship among nutrition, PA, and academic achievement, while controlling for socioeconomic status, age, and sex. A nonactive, unhealthy nutrition group and a physically active, healthy nutrition group were compared on standardized tests of academic achievement. Findings indicated that PA levels and proper nutrition significantly predicted achievement scores. Thus, the active, healthy nutrition group scored higher on reading, math, and science standardized achievement tests scores. There is a strong connection between healthy nutrition and adequate PA, and the average performance within the population. Thus, results from this study suggest a supporting relationship between students' health and academic achievement. Findings also provide implications for school and district policy changes. © 2018, American School Health Association.

The influence of materialism and ideal body internalization on body-dissatisfaction and body-shaping behaviors of young men and women: support for the Consumer Culture Impact Model.

PubMed

Guðnadóttir, Unnur; Garðarsdóttir, Ragna B

2014-04-01

Exposure to media images of the 'body-perfect' ideal has been partly blamed for the pursuit of thinness among women and muscularity among men. Research has largely overlooked the materialistic messages frequently associated with these images. We present findings from two studies with Icelandic students aged 18-21, one focusing on young women (n = 303) and one on young men (n = 226), which test associations of materialistic and body-perfect ideals with body dissatisfaction and excessive body shaping behaviors. In both studies, the internalization of materialistic values is strongly linked to the internalization of body-perfect ideals: the thin-ideal for young women, and the muscular-ideal for young men. A materialist value orientation also predicted body dissatisfaction in both studies, and was linked to body shaping behaviors, albeit differently for young women and men. Thus, the research identifies materialism as a further correlate of both body dissatisfaction and excessive body-shaping behaviors. The findings support Dittmar's (2008) Consumer Culture Impact Model, which proposes that the body-perfect and 'material good life' ideals jointly impact well-being. © 2014 Scandinavian Psychological Associations and John Wiley & Sons Ltd.

A new lead from genetic studies in depressed siblings: assessing studies of chromosome 3.

PubMed

Hamilton, Steven P

2011-08-01

Studies by Breen et al. and Pergadia et al. find evidence for genetic linkage between major depressive disorder and the same region on chromosome 3. The linked region contains the gene GRM7, which encodes a protein for the metabotropic glutamate receptor 7 (mGluR7). Both studies used affected sibling pairs, and neither was able to replicate its finding using association studies in individuals from larger population-based studies. Other family-based studies have also failed to find a signal in this region. Furthermore, there are some differences in how the phenotype was classified, with Breen et al. finding evidence only in the most severely affected patients. Nonetheless, the finding is not without other substantive support. A meta-analysis of 3,957 case subjects with major depressive disorder and 3,428 control subjects from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D), Genetics of Recurrent Early-onset Depression (GenRED), and the Genetic Association Information Network-MDD (GAIN-MDD) data sets demonstrated a region of association for major depressive disorder within GRM7. Thus, the significance of this finding remains uncertain, although it points to a gene that might hold significant promise for further developments in studying the pathophysiology and treatment of major depressive disorder.

Links between marital and parent-child interactions: moderating role of husband-to-wife aggression.

PubMed

Margolin, Gayla; Gordis, Elana B; Oliver, Pamella H

2004-01-01

The present study examined how marital conflict may compromise parenting by identifying interdependencies across marital and parent-child subsystems in a sample of 86 two-parent families with a child aged 9-13. The study used direct observation of three family discussions to examine interdependencies across family subsystems. The study also assessed whether a history of husband-to-wife aggression strengthened interdependencies. Overall, families with husband-to-wife aggression showed a negative tone that pervaded throughout the family. Consistent with theories about physically aggressive men tending to withdraw from conflict, fathers who had engaged in husband-to-wife aggression showed an association between marital hostilities and lower levels of empathy toward their children. Consistent with stress theories, women who had been exposed to husband-to-wife aggression showed a link between marital hostilities and negative affect when interacting with their children. These findings illustrate how a history of exposure to marital aggression can create a family environment of multiple risks for children. For children in families with prior marital aggression, ongoing marital hostilities can be linked to the additional risk of erosions in parental support.

Temperament in early childhood and peer interactions in third grade: the role of teacher-child relationships in early elementary grades.

PubMed

Rudasill, Kathleen Moritz; Niehaus, Kate; Buhs, Eric; White, Jamie M

2013-12-01

Children's interactions with peers in early childhood have been consistently linked to their academic and social outcomes. Although both child and classroom characteristics have been implicated as contributors to children's success, there has been scant research linking child temperament, teacher-child relationship quality, and peer interactions in the same study. The purpose of this study is to examine children's early temperament, rated at preschool age, as a predictor of interactions with peers (i.e., aggression, relational aggression, victimization, and prosociality) in third grade while considering teacher-child relationship quality in kindergarten through second grades as a moderator and mediator of this association. The sample (N=1364) was drawn from the NICHD Study of Early Child Care and Youth Development. Results from structural equation models indicated that teacher-child conflict in early elementary grades mediated links between children's temperament and later peer interactions. Findings underscore the importance of considering children's temperament traits and teacher-child relationship quality when examining the mechanisms of the development of peer interactions. © 2013.

Science teacher’s idea about environmental concepts in science learning as the first step of science teacher training

NASA Astrophysics Data System (ADS)

Tapilouw, M. C.; Firman, H.; Redjeki, S.; Chandra, D. T.

2018-05-01

To refresh natural environmental concepts in science, science teacher have to attend a teacher training. In teacher training, all participant can have a good sharing and discussion with other science teacher. This study is the first step of science teacher training program held by education foundation in Bandung and attended by 20 science teacher from 18 Junior High School. The major aim of this study is gathering science teacher’s idea of environmental concepts. The core of questions used in this study are basic competencies linked with environmental concepts, environmental concepts that difficult to explain, the action to overcome difficulties and references in teaching environmental concepts. There are four major findings in this study. First finding, most environmental concepts are taught in 7th grade. Second finding, most difficult environmental concepts are found in 7th grade. Third finding, there are five actions to overcome difficulties. Fourth finding, science teacher use at least four references in mastering environmental concepts. After all, teacher training can be a solution to reduce difficulties in teaching environmental concepts.

Interdisciplinary neurotoxicity inhalation studies: Carbon disulfide and carbonyl sulfide research in F344 rats

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sills, Robert C.; Harry, G. Jean; Valentine, William M.

2005-09-01

Inhalation studies were conducted on the hazardous air pollutants, carbon disulfide, which targets the central nervous system (spinal cord) and peripheral nervous system (distal portions of long myelinated axons), and carbonyl sulfide, which targets the central nervous system (brain). The objectives were to investigate the neurotoxicity of these compounds by a comprehensive evaluation of function, structure, and mechanisms of disease. Through interdisciplinary research, the major finding in the carbon disulfide inhalation studies was that carbon disulfide produced intra- and intermolecular protein cross-linking in vivo. The observation of dose-dependent covalent cross-linking in neurofilament proteins prior to the onset of lesions ismore » consistent with this process contributing to the development of the neurofilamentous axonal swellings characteristic of carbon disulfide neurotoxicity. Of significance is that valine-lysine thiourea cross-linking on rat globin and lysine-lysine thiourea cross-linking on erythrocyte spectrin reflect cross-linking events occurring within the axon and could potentially serve as biomarkers of carbon disulfide exposure and effect. In the carbonyl sulfide studies, using magnetic resonance microscopy (MRM), we determined that carbonyl sulfide targets the auditory pathway in the brain. MRM allowed the examination of 200 brain slices and made it possible to identify the most vulnerable sites of neurotoxicity, which would have been missed in our traditional neuropathology evaluations. Electrophysiological studies were focused on the auditory system and demonstrated decreases in auditory brain stem evoked responses. Similarly, mechanistic studies focused on evaluating cytochrome oxidase activity in the posterior colliculus and parietal cortex. A decrease in cytochrome oxidase activity was considered to be a contributing factor to the pathogenesis of carbonyl sulfide neurotoxicity.« less

Testosterone and sexual desire in healthy women and men.

PubMed

van Anders, Sari M

2012-12-01

Sexual desire is typically higher in men than in women, with testosterone (T) thought to account for this difference as well as within-sex variation in desire in both women and men. However, few studies have incorporated both hormonal and social or psychological factors in studies of sexual desire. The present study addressed how three psychological domains (sexual-relational, stress-mood, body-embodiment) were related to links between T and sexual desire in healthy adults and whether dyadic and solitary desire showed associations with T. Participants (n = 196) were recruited as part of the Partnering, Physiology, and Health study, which had 105 men and 91 women who completed questionnaires and provided saliva for cortisol and T assays. T was positively linked to solitary desire in women, with masturbation frequency influencing this link. In contrast, T was negatively correlated with dyadic desire in women, but only when cortisol and perceived social stress were controlled. Replicating past findings, no significant correlations between T and desire in men were apparent, but these analyses showed that the null association remained even when psychological and confound variables were controlled. Men showed higher desire than women, but masturbation frequency rather than T influenced this difference. Results were discussed in terms of challenges to assumptions of clear links between T and desire, gendered approaches to T, and the unitarity of desire.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Song, Tieling; Zhou, D.L., E-mail: zhoudl72@iphy.ac.cn

We study a hysteresis phenomenon in a rotating BEC with a weak link in a quasi-one-dimensional torus by proposing a microscopic theoretical model including a dissipation bath. By analyzing the role of dissipation and the decay rates of all the energy levels, we are able to give a microscopic interpretation of hysteresis recently observed in the experiment and confirm that the hysteresis is the result of the presence of metastable state. In particular, we obtain the hysteresis loops in a quench process just as that in the experiment. We also find that the shape and size of the hysteresis loopmore » change drastically with the strength of the link.« less

Golden tapetal reflex in male patients with X-linked retinitis pigmentosa. Case report and practical implications.

PubMed

van Osch, L; van Schooneveld, M; Bleekerwagemakers, E M

1990-12-01

The golden tapetal reflex in the ocular fundus is considered pathognomonic of the carrier state in some families with X-linked retinitis pigmentosa (XRP). Reports concerning affected males with this characteristic reflex are scarce. A six-year-old boy with XRP having a tapetal reflex is described. Recently the tapetal reflex has drawn attention in linkage studies. XRP is probably genetically heterogeneous and has at least two genetic forms. The finding of a tapetal reflex in one or more female carriers in a family with XRP may be helpful in differentiating between these two genetic forms.

Gender Differences in Perceptions of Resources and Turnover Intentions of Work-Linked Couples in Masculine Occupations.

PubMed

Huffman, Ann Hergatt; Olson, Kristine J

2017-10-01

Employees in work-linked marriages have spouses that share the same family and the same workplace and/or occupation. Whereas, in recent years, there has been increasingly more research on dual-career marriages (i.e. both spouses work, but not necessarily at the same workplace and/or occupation), there has been very little research on work-linked marriages. The current study focuses on work resources (i.e. family supportive supervisor behaviour and job control) as key mediating processes that explain the effect of gender on turnover intentions among work-linked employees in masculine occupations (i.e. military). Investigating gender differences is important because, compared with men, women are more likely to be in work-linked marriages and to leave their jobs. Based on role theory and conservation of resource theory, we predicted that gender was related to turnover intentions, and this relationship would be mediated by key explanatory variables (i.e. family supportive supervisor behaviours, job control and psychological distress). Mediation analyses, conducted on a sample of men and women in work-linked marriages (n = 309), provide support for the hypothesized model. These findings offer guidance for understanding gender differences among work-linked employees in masculine occupations, and how these differences can affect important outcomes such as turnover intentions. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

In Vivo Immune Responses of Cross-Linked Electrospun Tilapia Collagen Membrane.

PubMed

Hassanbhai, Ammar Mansoor; Lau, Chau Sang; Wen, Feng; Jayaraman, Praveena; Goh, Bee Tin; Yu, Na; Teoh, Swee-Hin

2017-10-01

Collagen has been used extensively in tissue engineering applications. However, the source of collagen has been primarily bovine and porcine. In view of the potential risk of zoonotic diseases and religious constraints associated with bovine and porcine collagen, fish collagen was examined as an alternative. The aim of this study is to use tilapia fish collagen to develop a cross-linked electrospun membrane to be used as a barrier membrane in guided bone regeneration. As there is limited data available on the cytotoxicity and immunogenicity of cross-linked tilapia collagen, in vitro and in vivo tests were performed to evaluate this in comparison to the commercially available Bio-Gide ® membrane. In this study, collagen was extracted and purified from tilapia skin and electrospun into a nanofibrous membrane. The resultant membrane was cross-linked to obtain a cross-linked electrospun tilapia collagen (CETC) membrane, which was characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), degradation studies, cytotoxicity studies, and cell proliferation studies. The membranes were also implanted subcutaneously in rats and the host immune responses were examined. The DSC data showed that cross-linking increased the denaturation temperature of tilapia collagen to 58.3°C ± 1.4°C. The in vitro tests showed that CETC exhibited no cytotoxicity toward murine fibroblast L929 cells, and culture of murine preosteoblast MC3T3-E1 cells demonstrated better proliferation on CETC as compared to Bio-Gide. When implanted in rats, CETC caused a higher production of interleukin IL-6 at early time points as compared to Bio-Gide, but there was no long-term inflammatory responses after the acute inflammation phase. This finding was supported with histology data, which clearly illustrated that CETC has a decreased inflammatory response comparable to the benchmark control group. In all, this study demonstrated the viability for the use of CETC as a tissue engineering scaffold and provides an insight on the in vivo immune responses toward xenogenic collagen scaffolds.

A Contemporary Review of the Relationship between Red Meat Consumption and Cardiovascular Risk

PubMed Central

Bronzato, Sofia; Durante, Alessandro

2017-01-01

Cardiovascular diseases burden is increasing due to aging populations and represents one of the major health issues worldwide. Dietary habits have been extensively studied in the cardiovascular field despite the difficulty in the quantification of the assumption of each single food and the observation that several foods affect cardiovascular risk with opposite effects. Moreover, some older findings have been reverted by more recent studies. Red meat has been widely studied in this context, and it has been suggested to increase cardiovascular risk primarily by causing dyslipidemia. Our aim is to review the relationship between red meat assumption and cardiovascular risk and to present novel findings regarding their link. PMID:28656096

Intimate Partner Violence, Maternal Gatekeeping, and Child Conduct Problems

PubMed Central

Zvara, Bharathi J.; Mills-Koonce, W. Roger; Cox, Martha

2017-01-01

We examined the mediating role of parenting behavior on the relationship between intimate partner violence and child conduct problems, as well as the moderating role of maternal gatekeeping to these associations. The sample (N = 395) is from a longitudinal study of rural poverty in the eastern United States, exploring the ways in which child, family, and contextual factors shape child development over time. Study findings indicate that a father’s harsh–intrusive parenting behavior may be a key mediating pathway linking intimate partner violence and child conduct problems. Study findings further provide evidence for problematic outcomes for children when mothers encourage fathers with high levels of harsh–intrusive parenting to interact with their children. PMID:28943690

DDT Exposure in Utero and Breast Cancer.

PubMed

Cohn, Barbara A; La Merrill, Michele; Krigbaum, Nickilou Y; Yeh, Gregory; Park, June-Soo; Zimmermann, Lauren; Cirillo, Piera M

2015-08-01

Currently no direct evidence links in utero dichlorodiphenyltrichloroethane (DDT) exposure to human breast cancer. However, in utero exposure to another xenoestrogen, diethylstilbestrol, predicts an increased breast cancer risk. If this finding extends to DDT, it could have far-reaching consequences. Many women were heavily exposed in utero during widespread DDT use in the 1960s. They are now reaching the age of heightened breast cancer risk. DDT exposure persists and use continues in Africa and Asia without clear knowledge of the consequences for the next generation. In utero exposure to DDT is associated with an increased risk of breast cancer. This was a case-control study nested in a prospective 54-year follow-up of 9300 daughters in the Child Health and Development Studies pregnancy cohort (n = 118 breast cancer cases, diagnosed by age 52 y and 354 controls matched on birth year). Kaiser Foundation Health Plan members who received obstetric care in Alameda County, California, from 1959 to 1967, and their adult daughters participated in the study. Daughters' breast cancer diagnosed by age 52 years as of 2012 was measured. Maternal o,p'-DDT predicted daughters' breast cancer (odds ratio fourth quartile vs first = 3.7, 95% confidence interval 1.5-9.0). Mothers' lipids, weight, race, age, and breast cancer history did not explain the findings. This prospective human study links measured DDT exposure in utero to risk of breast cancer. Experimental studies are essential to confirm results and discover causal mechanisms. Findings support classification of DDT as an endocrine disruptor, a predictor of breast cancer, and a marker of high risk.

Oligomerisation of Synaptobrevin-2 Studied by Native Mass Spectrometry and Chemical Cross-Linking

NASA Astrophysics Data System (ADS)

Wittig, Sabine; Haupt, Caroline; Hoffmann, Waldemar; Kostmann, Susann; Pagel, Kevin; Schmidt, Carla

2018-06-01

Synaptobrevin-2 is a key player in signal transmission in neurons. It forms, together with SNAP25 and Syntaxin-1A, the neuronal soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex and mediates exocytosis of synaptic vesicles with the pre-synaptic membrane. While Synaptobrevin-2 is part of a four-helix bundle in this SNARE complex, it is natively unstructured in the absence of lipids or other SNARE proteins. Partially folded segments, presumably SNARE complex formation intermediates, as well as formation of Synaptobrevin-2 dimers and oligomers, were identified in previous studies. Here, we employ three Synaptobrevin-2 variants—the full-length protein Syb(1-116), the soluble, cytosolic variant Syb(1-96) as well as a shorter version Syb(49-96) containing structured segments but omitting a trigger site for SNARE complex formation—to study oligomerisation in the absence of interaction partners or when incorporated into the lipid bilayer of liposomes. Combining native mass spectrometry with chemical cross-linking, we find that the truncated versions show increased oligomerisation. Our findings from both techniques agree well and confirm the presence of oligomers in solution while membrane-bound Synaptobrevin-2 is mostly monomeric. Using ion mobility mass spectrometry, we could further show that lower charge states of Syb(49-96) oligomers, which most likely represent solution structures, follow an isotropic growth curve suggesting that they are intrinsically disordered. From a technical point of view, we show that the combination of native ion mobility mass spectrometry with chemical cross-linking is well-suited for the analysis of protein homo-oligomers. [Figure not available: see fulltext.

Invertebrate hematopoiesis: an anterior proliferation center as a link between the hematopoietic tissue and the brain.

PubMed

Noonin, Chadanat; Lin, Xionghui; Jiravanichpaisal, Pikul; Söderhäll, Kenneth; Söderhäll, Irene

2012-11-20

During evolution, the innate and adaptive immune systems were developed to protect organisms from non-self substances. The innate immune system is phylogenetically more ancient and is present in most multicellular organisms, whereas adaptive responses are restricted to vertebrates. Arthropods lack the blood cells of the lymphoid lineage and oxygen-carrying erythrocytes, making them suitable model animals for studying the regulation of the blood cells of the innate immune system. Many crustaceans have a long life span and need to continuously synthesize blood cells, in contrast to many insects. The hematopoietic tissue (HPT) of Pacifastacus leniusculus provides a simple model for studying hematopoiesis, because the tissue can be isolated, and the proliferation of stem cells and their differentiation can be studied both in vivo and in vitro. Here, we demonstrate new findings of a physical link between the HPT and the brain. Actively proliferating cells were localized to an anterior proliferation center (APC) in the anterior part of the tissue near the area linking the HPT to the brain, whereas more differentiated cells were detected in the posterior part. The central areas of HPT expand in response to lipopolysaccharide-induced blood loss. Cells isolated from the APC divide rapidly and form cell clusters in vitro; conversely, the cells from the remaining HPT form monolayers, and they can be induced to differentiate in vitro. Our findings offer an opportunity to learn more about invertebrate hematopoiesis and its connection to the central nervous system, thereby obtaining new information about the evolution of different blood and nerve cell lineages.

Genotype-phenotype variations in five Spanish families with Norrie disease or X-linked FEVR.

PubMed

Riveiro-Alvarez, Rosa; Trujillo-Tiebas, Maria José; Gimenez-Pardo, Ascension; Garcia-Hoyos, Maria; Cantalapiedra, Diego; Lorda-Sanchez, Isabel; Rodriguez de Alba, Marta; Ramos, Carmen; Ayuso, Carmen

2005-09-02

Norrie disease (OMIM 310600) is a rare X-linked disorder characterized by congenital blindness in males. Approximately 40 to 50% of the cases develop deafness and mental retardation. X-linked familial exudative vitreoretinopathy (XL-FEVR) is a hereditary ocular disorder characterized by a failure of peripheral retinal vascularization. Both X-linked disorders are due to mutations in the NDP gene, which encodes a 133 amino acid protein called Norrin, but autosomal recessive (AR) and autosomal dominant (AD) forms of FEVR have also been described. In this study, we report the molecular findings and the related phenotype in five Spanish families affected with Norrie disease or XL-FEVR due to mutations of the NDP gene. The study was conducted in 45 subjects from five Spanish families. These families were clinically diagnosed with Norrie disease or similar conditions. The three exons of the NDP gene were analyzed by automatic DNA sequencing. Haplotype analyses were also performed. Two new nonsense mutations, apart from other mutations previously described in the NDP gene, were found in those patients affected with ND or X-linked FEVR. An important genotype-phenotype variation was found in relation to the different mutations of the NDP gene. In fact, the same mutation may be responsible for different phenotypes. We speculate that there might be other molecular factors that interact in the retina with Norrin, which contribute to the resultant phenotypes.

The role of suggestibility in determinations of Miranda abilities: a study of the Gudjonsson Suggestibility Scales.

PubMed

Rogers, Richard; Harrison, Kimberly S; Rogstad, Jill E; LaFortune, Kathryn A; Hazelwood, Lisa L

2010-02-01

Traditionally, high levels of suggestibility have been widely assumed to be linked with diminished Miranda abilities, especially in relationship to the voluntariness of waivers. The current investigation examined suggestibility on the Gudjonsson Suggestibility Scales in a multisite study of pretrial defendants. One important finding was the inapplicability of British norms to American jurisdictions. Moreover, suggestibility appeared unrelated to Miranda comprehension, reasoning, and detainees' perceptions of police coercion. In testing rival hypotheses, defendants with high compliance had significantly lower Miranda comprehension and ability to reason about exercising Miranda rights than their counterparts with low compliance. Implications of these findings to forensic practice are examined.

Self-descriptions on LinkedIn: Recruitment or friendship identity?

PubMed

Garcia, Danilo; Cloninger, Kevin M; Granjard, Alexandre; Molander-Söderholm, Kristian; Amato, Clara; Sikström, Sverker

2018-04-26

We used quantitative semantics to find clusters of words in LinkedIn users' self-descriptions to an employer or a friend. Some of these clusters discriminated between worker and friend conditions (e.g., flexible vs. caring) and between LinkedIn users with high and low education (e.g., analytical vs. messy). © 2018 The Institute of Psychology, Chinese Academy of Sciences and John Wiley & Sons Australia, Ltd.

[Cognitive impairments accompanying the burnout syndrome - a review].

PubMed

Riedrich, Karin; Weiss, Elisabeth M; Dalkner, Nina; Reininghaus, Eva; Papousek, Ilona; Schwerdtfeger, Andreas; Lackner, Helmut K; Reininghaus, Bernd

2017-03-01

The rising prevalence of the burnout syndrome has increasingly moved it into the focus of scientific interest. In addition to emotional exhaustion and depersonalization, particularly reduced personal accomplishment has strong societal and economic effects. In recent years reduced personal accomplishment has increasingly been linked to cognitive impairment. However, up to now only a few studies have objectively assessed cognitive deficits in burnout patients. This article gives an overview of 16 studies which examined cognitive abilities in burnout patients. The findings are partly contradictory, probably due to methodical differences. Consensus has emerged concerning impairments of executive functions, i.a. vigilance, and memory updating and monitoring. Multifactorial causation may underlie the cognitive impairments. Targeted longitudinal studies are necessary in order to identify the affected cognitive functions and be able to make causal inferences on links between the burnout syndrome and specific cognitive impairments.

Cross-disciplinary links in environmental systems science: Current state and claimed needs identified in a meta-review of process models.

PubMed

Ayllón, Daniel; Grimm, Volker; Attinger, Sabine; Hauhs, Michael; Simmer, Clemens; Vereecken, Harry; Lischeid, Gunnar

2018-05-01

Terrestrial environmental systems are characterised by numerous feedback links between their different compartments. However, scientific research is organized into disciplines that focus on processes within the respective compartments rather than on interdisciplinary links. Major feedback mechanisms between compartments might therefore have been systematically overlooked so far. Without identifying these gaps, initiatives on future comprehensive environmental monitoring schemes and experimental platforms might fail. We performed a comprehensive overview of feedbacks between compartments currently represented in environmental sciences and explores to what degree missing links have already been acknowledged in the literature. We focused on process models as they can be regarded as repositories of scientific knowledge that compile findings of numerous single studies. In total, 118 simulation models from 23 model types were analysed. Missing processes linking different environmental compartments were identified based on a meta-review of 346 published reviews, model intercomparison studies, and model descriptions. Eight disciplines of environmental sciences were considered and 396 linking processes were identified and ascribed to the physical, chemical or biological domain. There were significant differences between model types and scientific disciplines regarding implemented interdisciplinary links. The most wide-spread interdisciplinary links were between physical processes in meteorology, hydrology and soil science that drive or set the boundary conditions for other processes (e.g., ecological processes). In contrast, most chemical and biological processes were restricted to links within the same compartment. Integration of multiple environmental compartments and interdisciplinary knowledge was scarce in most model types. There was a strong bias of suggested future research foci and model extensions towards reinforcing existing interdisciplinary knowledge rather than to open up new interdisciplinary pathways. No clear pattern across disciplines exists with respect to suggested future research efforts. There is no evidence that environmental research would clearly converge towards more integrated approaches or towards an overarching environmental systems theory. Copyright © 2017 Elsevier B.V. All rights reserved.

Preschool acuity of the approximate number system correlates with school math ability.

PubMed

Libertus, Melissa E; Feigenson, Lisa; Halberda, Justin

2011-11-01

Previous research shows a correlation between individual differences in people's school math abilities and the accuracy with which they rapidly and nonverbally approximate how many items are in a scene. This finding is surprising because the Approximate Number System (ANS) underlying numerical estimation is shared with infants and with non-human animals who never acquire formal mathematics. However, it remains unclear whether the link between individual differences in math ability and the ANS depends on formal mathematics instruction. Earlier studies demonstrating this link tested participants only after they had received many years of mathematics education, or assessed participants' ANS acuity using tasks that required additional symbolic or arithmetic processing similar to that required in standardized math tests. To ask whether the ANS and math ability are linked early in life, we measured the ANS acuity of 200 3- to 5-year-old children using a task that did not also require symbol use or arithmetic calculation. We also measured children's math ability and vocabulary size prior to the onset of formal math instruction. We found that children's ANS acuity correlated with their math ability, even when age and verbal skills were controlled for. These findings provide evidence for a relationship between the primitive sense of number and math ability starting early in life. 2011 Blackwell Publishing Ltd.

Prefrontal and medial temporal contributions to episodic memory-based reasoning.

PubMed

Suzuki, Chisato; Tsukiura, Takashi; Mochizuki-Kawai, Hiroko; Shigemune, Yayoi; Iijima, Toshio

2009-03-01

Episodic memory retrieval and reasoning are fundamental psychological components of our daily lives. Although previous studies have investigated the brain regions associated with these processes separately, the neural mechanisms of reasoning based on episodic memory retrieval are largely unknown. Here, we investigated the neural correlates underlying episodic memory-based reasoning using functional magnetic resonance imaging (fMRI). During fMRI scanning, subjects performed three tasks: reasoning, episodic memory retrieval, and episodic memory-based reasoning. We identified dissociable activations related to reasoning, episodic memory retrieval, and linking processes between the two. Regions related to reasoning were identified in the left ventral prefrontal cortices (PFC), and those related to episodic memory retrieval were found in the right medial temporal lobe (MTL) regions. In addition, activations predominant in the linking process between the two were found in the left dorsal and right ventral PFC. These findings suggest that episodic memory-based reasoning is composed of at least three processes, i.e., reasoning, episodic memory retrieval, and linking processes between the two, and that activation of both the PFC and MTL is crucial in episodic memory-based reasoning. These findings are the first to demonstrate that PFC and MTL regions contribute differentially to each process in episodic memory-based reasoning.

Are gonadal steroids linked with orgasm perceptions and sexual assertiveness in women and men?

PubMed

van Anders, Sari M; Dunn, Emily J

2009-08-01

Past findings suggest links between orgasms and testosterone (T), as well as sexuality and estradiol (E), and we examined hormone-orgasm links in this study via two hypotheses (below). Participants were 86 women and 91 men who provided a saliva sample and completed a demographics questionnaire, the Orgasm Checklist (Mah and Binik, 2002), the Hurlbert (1991) Index of Sexual Assertiveness, and the Sexual Desire Inventory (Spector and Fremeth, 1996). Results supported the first hypothesis of correlations between T and positive orgasm experience in women, specifically with the relaxation, soothing, and peaceful items in both partnered and solitary orgasm contexts. Results also indicated correlations between E and flooding and spreading items in a solitary orgasm context. There were no associations between hormones and men's perceptions of their orgasm experiences. There was no support for the second hypothesis of associations between higher T and more sexual assertiveness. Post hoc analyses showed associations between E and women's sexual desire, and T and men's sexual desire. We discuss implications of these findings including that solitary vs. partnered orgasm experiences may differ, and suggest that T might be associated with perceptions of psychological experiences of orgasms, and E might be associated with perceptions of physical experiences of orgasms.

Preschool Acuity of the Approximate Number System Correlates with School Math Ability

PubMed Central

Libertus, Melissa E.; Feigenson, Lisa; Halberda, Justin

2012-01-01

Previous research shows a correlation between individual differences in people’s school math abilities and the accuracy with which they rapidly and nonverbally approximate how many items are in a scene. This finding is surprising because the Approximate Number System (ANS) underlying numerical estimation is shared with infants and non-human animals who never acquire formal mathematics. However, it remains unclear whether the link between individual differences in math ability and the ANS depends on formal mathematics instruction. Earlier studies demonstrating this link tested participants only after they had received many years of mathematics education, or assessed participants’ ANS acuity using tasks that required additional symbolic or arithmetic processing similar to that required in standardized math tests. To ask whether the ANS and math ability are linked early in life, we measured the ANS acuity of 200 3- to 5-year-old children using a task that did not also require symbol use or arithmetic calculation. We also measured children’s math ability and vocabulary size prior to the onset of formal math instruction. We found that children’s ANS acuity correlated with their math ability, even when age and verbal skills were controlled for. These findings provide evidence for a relationship between the primitive sense of number and math ability starting early in life. PMID:22010889

Distress tolerance is linked to unhealthy eating through pain catastrophizing.

PubMed

Emami, Ashley S; Woodcock, Anna; Swanson, Heidi E; Kapphahn, Teresa; Pulvers, Kim

2016-12-01

Low distress tolerance, an important component of emotion regulation, is a risk factor for unhealthy eating. Identifying factors which explain the link between distress tolerance and unhealthy eating can advance the understanding of problematic eating and inform prevention and treatment of obesity and eating disorders. The present study examines pain catastrophizing as a mediator between distress tolerance and unhealthy eating in a nonclinical population, which has received little attention despite being a risk factor for unhealthy eating behaviors. The Distress Tolerance Scale (DTS), Pain Catastrophizing Scale (PCS), and the Dutch Eating Behavior Questionnaire (DEBQ), were administered to 171 college students (62.6% female, 38.6% White, 28.1% Hispanic). There was no evidence of a significant direct effect of distress tolerance on unhealthy eating. However, as hypothesized, there was a significant indirect or mediated effect of pain catastrophizing on the relationship between distress tolerance and unhealthy eating. Individuals low in distress tolerance reported higher pain catastrophizing, and a result, these individuals also reported higher levels of unhealthy eating. These findings introduce pain catastrophizing as an influential variable in the link between distress tolerance and unhealthy eating. Findings suggest that reducing catastrophic thinking about pain may be a worthy target of intervention in reducing unhealthy eating. Copyright © 2016 Elsevier Ltd. All rights reserved.

Sense of community and informal social control among lower income households: the role of homeownership and collective efficacy in reducing subjective neighborhood crime and disorder.

PubMed

Lindblad, Mark R; Manturuk, Kim R; Quercia, Roberto G

2013-03-01

We examine the link between homeownership, collective efficacy, and subjective neighborhood crime and disorder. Although prior research suggests that homeownership provides social benefits, the housing downturn and foreclosure crisis, coupled with mounting evidence that people self-select into housing, raise questions about the role of homeownership. We adjust for respondents' decision to own or rent using a nationwide sample of lower-income households. We account for demographic and neighborhood characteristics as well as ratings of individual efficacy. We present a structural equation model that identifies how sense of community and informal social control jointly contribute to collective efficacy. The latent collective efficacy construct mediates the impact of homeownership on resident's perceptions of neighborhood disorder. Such perceptions matter because they have been linked to resident's physical and mental health. Our findings demonstrate that when coupled with sustainable mortgages, homeownership exerts a robust yet indirect effect in reducing subjective neighborhood crime and disorder. Our model also links collective efficacy to neighborhood racial homogeneity, a finding which presents challenges for the study of diversity and community. We discuss sense of community research as well as sustainable mortgages and implications of the foreclosure crisis for the future of homeownership opportunities among lower income households and neighborhoods.

Carbyne from first principles: chain of C atoms, a nanorod or a nanorope.

PubMed

Liu, Mingjie; Artyukhov, Vasilii I; Lee, Hoonkyung; Xu, Fangbo; Yakobson, Boris I

2013-11-26

We report an extensive study of the properties of carbyne using first-principles calculations. We investigate carbyne's mechanical response to tension, bending, and torsion deformations. Under tension, carbyne is about twice as stiff as the stiffest known materials and has an unrivaled specific strength of up to 7.5 × 10(7) N·m/kg, requiring a force of ∼10 nN to break a single atomic chain. Carbyne has a fairly large room-temperature persistence length of about 14 nm. Surprisingly, the torsional stiffness of carbyne can be zero but can be "switched on" by appropriate functional groups at the ends. Further, under appropriate termination, carbyne can be switched into a magnetic semiconductor state by mechanical twisting. We reconstruct the equivalent continuum elasticity representation, providing the full set of elastic moduli for carbyne, showing its extreme mechanical performance (e.g., a nominal Young's modulus of 32.7 TPa with an effective mechanical thickness of 0.772 Å). We also find an interesting coupling between strain and band gap of carbyne, which is strongly increased under tension, from 2.6 to 4.7 eV under a 10% strain. Finally, we study the performance of carbyne as a nanoscale electrical cable and estimate its chemical stability against self-aggregation, finding an activation barrier of 0.6 eV for the carbyne-carbyne cross-linking reaction and an equilibrium cross-link density for two parallel carbyne chains of 1 cross-link per 17 C atoms (2.2 nm).

What Helps Children in a Pupil Referral Unit (PRU)? An Exploration into the Potential Protective Factors of a PRU as Identified by Children and Staff

ERIC Educational Resources Information Center

Hart, Natalie

2013-01-01

Previous studies have focused on the views of excluded children or those finding themselves in Pupil Referral Units (PRUs). Few, however, have focused on exploring views from a resilience perspective. Studies linked to resilience have tended to focus on exploring factors through quantitative rather than qualitative measures. This piece of research…

Antibody-linked drug shrinks various types of tumors in preclinical study | Center for Cancer Research

Cancer.gov

A preclinical study by Center for Cancer Research investigators and colleagues shows that a drug guided by an attached target-seeking antibody can recognize cells infiltrating tumors, the tumor stroma, and cause various types of tumors to shrink, and in many cases, disappear. Their findings suggest that when stromal cells take up the ADC, they cleave the drug from the antibody

Does Child Abuse and Neglect Explain the Overrepresentation of Aboriginal and Torres Strait Islander Young People in Youth Detention? Findings from a Birth Cohort Study

ERIC Educational Resources Information Center

Doolan, Ivan; Najman, Jake M.; Mills, Ryan; Cherney, Adrian; Strathearn, Lane

2013-01-01

Objective: Determine whether a history of family social disadvantage and/or child abuse and neglect explain the overrepresentation of Indigenous Australian young people in youth detention. Methods: Maternal survey data from the Mater University Study of Pregnancy was linked with child abuse and neglect and youth justice data from the Queensland…

Maternal Attributions of Infant Behavior and Parenting in Toddlerhood Predict Teacher-Rated Internalizing Problems in Childhood.

PubMed

Wagner, Nicholas J; Gueron-Sela, Noa; Bedford, Rachael; Propper, Cathi

2018-06-12

Social-information-processing theories of parenting posit that parents' beliefs and attributions about their children's behaviors contribute to how parents interact with their children. The purpose of this study was to examine the associations between negative parenting attributions in infancy, harsh-intrusive parenting in toddlerhood, and children's internalizing problems (IPs) in early childhood. Using data from a diverse longitudinal study (n = 206), the current study used a structural equation modeling approach to test if mothers' negative attributions measured at 6 months predicted teacher ratings of children's IPs in 1st grade, as well as the extent to which observed harsh-intrusive parenting behaviors measured at ages 1, 2, and 3 years mediated this link. Maternal negative attributions in infancy predict more IPs in 1st grade, but this link becomes nonsignificant when observed harsh-intrusive parenting is included as a mediator. A significant indirect effect suggests that harsh-intrusive parenting mediates the association between early negative attributions and eventual IPs. Findings from this study identify harsh-intrusive parenting behaviors as one potential mechanism through which the effects of early attributions are carried forward to influence children's IPs. The developmental and clinical implications of these findings are discussed.

About Looking: Vision, Transformation, and the Education of the Eye in Discourses of School Renewal Past and Present

ERIC Educational Resources Information Center

Burke, Catherine

2010-01-01

This article reports the interim findings of historical research, funded by the British Academy (2007), which is exploring the possibilities of prosopography (the study of biographies linked through a common purpose, philosophy or practice) in researching the relationship between educational thought and school design since World War Two. Through…

Job Satisfaction among Accounting and Finance Academics: Empirical Evidence from Irish Higher Education Institutions

ERIC Educational Resources Information Center

Byrne, Marann; Chughtai, Aamir Ali; Flood, Barbara; Willis, Pauline

2012-01-01

The central aim of the present study was to examine the levels of job satisfaction among accounting and finance academics in Irish higher education institutions. Additionally, this research sought to uncover the factors linked to the overall job satisfaction of these teachers. The findings showed that while, participants were generally satisfied…

Exploring the Adult Learning Research Field by Analysing Who Cites Whom

ERIC Educational Resources Information Center

Nylander, Erik; Österlund, Lovisa; Fejes, Andreas

2018-01-01

In this article we report on findings from a large-scale bibliographic study conducted based on the citation practices within the field of research on adult learning. Our data consist of 151,261 citation links between more than 33,000 different authors whose papers were published in five leading international journals in the field of adult…

Linking Developmental Themes to Theories in the Autobiographical Narratives of Life-Span Development Students

ERIC Educational Resources Information Center

Mayo, Joseph A.

2017-01-01

Prior research findings point to the efficacy of using autobiographical life-story narration as a learning tool in undergraduate classes. The current study seeks to add to the existing literature on this topic by performing a qualitative analysis across events recorded in students' autobiographical narratives. The purpose of this analysis is to…

The Ideas of Greek High School Students about the "Ozone Layer."

ERIC Educational Resources Information Center

Boyes, Edward; Stanisstreet, Martin; Papantoniou, Vasso Spiliotopoulou

1999-01-01

Describes a study of Greek high school students' (n=116) perceptions of the ozone layer. Finds that students have a good understanding of the position and purpose of the ozone layer in terms of protection from ultraviolet rays, but students also hold misconceptions linking the ozone layer to the greenhouse effect and other forms of local…

Direct and Indirect Links between the Couple Relationship and Child School Outcomes

ERIC Educational Resources Information Center

Chen, Hui-Hua; Liang, Yi-Ching; Gapp, Susan C.; Newland, Lisa A.; Giger, Jarod T.; Lin, Chunn-Ying

2017-01-01

This study measured aspects of the couple relationship to examine direct and indirect relations with parental involvement in education and children's school outcomes. The sample (n = 100) consisted of families that have at least one child between the ages of 8 and 11 in urban central Taiwan. Findings indicated that couple relationship quality is…

A Mixture-Model Approach to Linking ADHD to Adolescent Onset of Illicit Drug Use

ERIC Educational Resources Information Center

Malone, Patrick S.; Van Eck, Kathryn; Flory, Kate; Lamis, Dorian A.

2010-01-01

Prior research findings have been mixed as to whether attention-deficit/hyperactivity disorder (ADHD) is related to illicit drug use independent of conduct problems (CP). With the current study, the authors add to this literature by investigating the association between trajectories of ADHD symptoms across childhood and adolescence and onset of…

Adolescents' Exposure to Sexy Media Does Not Hasten the Initiation of Sexual Intercourse

ERIC Educational Resources Information Center

Steinberg, Laurence; Monahan, Kathryn C.

2011-01-01

It is widely believed that exposure to sexy content in the mass media leads teenagers to become sexually active. Although most research linking sexy media exposure to adolescents' sexual behavior is cross-sectional, several recent, well-publicized longitudinal studies purport to find a causal connection, which has alarmed the public and prompted…

How doth the little busy bee: unexpected metabolism.

PubMed

Barros, L Felipe; Sierralta, Jimena; Weber, Bruno

2015-01-01

Brain energy metabolism powers information processing and behavior, much as electricity powers a computer. However, a recent study in insects suggests that this relationship is more interesting, causally linking aggressive behavior to energetics. These findings may also shed new light on aerobic glycolysis, a long-standing riddle of human brain physiology. Copyright © 2014 Elsevier Ltd. All rights reserved.

Linking Teaching for Understanding to Practice in a U.S. History Class

ERIC Educational Resources Information Center

DiCamillo, Lorrei

2010-01-01

The author reports findings from a study that explored the methods a U.S. history teacher used to promote students' higher order thinking and engagement. The teacher, Mr. Scott (a pseudonym), challenged his urban high school students to develop stronger understandings of history by enacting elements of the teaching for understanding (TFU)…

Texas Hold 'em Online Poker: A Further Examination

ERIC Educational Resources Information Center

Hopley, Anthony A. B.; Dempsey, Kevin; Nicki, Richard

2012-01-01

Playing Texas Hold 'em Online Poker (THOP) is on the rise. However, there is relatively little research examining factors that contribute to problem gambling in poker players. The aim of this study was to extend the research findings of Hopley and Nicki (2010). The negative mood states of depression, anxiety and stress were found to be linked to…

Children, Gender, and Social Structure: An Analysis of the Contents of Letters to Santa Claus.

ERIC Educational Resources Information Center

Richardson, John G.; Simpson, Carl H.

1982-01-01

Focusing on those elements of children's preferences which link gender to social structure, the present study analyzes children's letters to Santa Claus. Findings show boys' and girls' requests to be similar when aspects of the child's world are measured and quite different when qualities representing the adult social order are measured.…

Making a College Course Matter for Pre-K Professionals: Supports Needed for Success. Research Brief

ERIC Educational Resources Information Center

Hatfield, Bridget E.; LoCasale-Crouch, Jennifer

2013-01-01

Given the increased enrollment in pre-K programs coupled with a lack of teacher education that consistently links to child development, this study examines a new course developed to support early childhood professionals in implementing effective teacher-child interactions. Findings suggest that an effective course can be scaled-up and used in…

Achievement Goals and Achievement Emotions: Testing a Model of Their Joint Relations with Academic Performance

ERIC Educational Resources Information Center

Pekrun, Reinhard; Elliot, Andrew J.; Maier, Markus A.

2009-01-01

The authors propose a theoretical model linking achievement goals and achievement emotions to academic performance. This model was tested in a prospective study with undergraduates (N = 213), using exam-specific assessments of both goals and emotions as predictors of exam performance in an introductory-level psychology course. The findings were…

Learning to Teach Sport Education in Russia: Factors Affecting Model Understanding and Intentions to Teach

ERIC Educational Resources Information Center

Glotova, Olga Nikolaevna; Hastie, Peter Andrew

2014-01-01

While remarkably positive findings have been presented in research focusing on Sport Education in school settings, investigations on how preservice teachers learn to teach a new curriculum in physical education have been described as "the missing link" in curriculum research. The purpose of this study was to introduce Sport Education to…

The Link between the Emotional Consequences of Child Sexual Abuse and School Experiences

ERIC Educational Resources Information Center

Phasha, Tlakale Nareadi

2008-01-01

The present paper presents findings drawn from a qualitative study that investigated the impact of childhood sexual abuse on school functioning among young adult survivors in South Africa. Data were obtained by means of in-depth individual interviews with 22 young adults. Analyzing the interviews following procedures aligned to a grounded theory…

Self-Control and Academic Performance: Two Field Studies on University Citizenship Behavior and Counterproductive Academic Behavior

ERIC Educational Resources Information Center

Zettler, Ingo

2011-01-01

Self-control affects, among other things, individuals' performance and criminal or deviant behavior. Herein, the construct of self-control is linked to rather specific criteria in an academic context, as derived from findings in the area of organizational psychology. Specifically, it is assumed that students' self-control impacts university…

Putting Languages on the (Drop Down) Menu: Innovative Writing Frames in Modern Foreign Language Teaching

ERIC Educational Resources Information Center

Taylor, Alison; Lazarus, Elisabeth; Cole, Ruth

2005-01-01

The paper presents findings from a school-based collaborative research project, the InterActive Education Project, which linked teachers, teacher educators and university researchers in English secondary schools (see Sutherland et al., 2004). It centres on a case study from one school where students used a simple yet highly effective electronic…

Of What Benefit and to Whom? Linking Australian Humanities Research with Its "End Users"

ERIC Educational Resources Information Center

Pitman, Tim; Berman, Judith E.

2009-01-01

There is increasing pressure for university researchers to secure "end-user" support for their research projects. Yet the ways in which this imperative affects humanities researchers, operating in a science-centric funding environment, have not yet been fully explored. This paper presents the findings of an empirical study into the…

Temperament and Teacher-Child Conflict in Preschool: The Moderating Roles of Classroom Instructional and Emotional Support

ERIC Educational Resources Information Center

Rudasill, Kathleen Moritz; Hawley, Leslie; Molfese, Victoria J.; Tu, Xiaoqing; Prokasky, Amanda; Sirota, Kate

2016-01-01

Research Findings: This study is an examination of (a) links between preschool children's temperament (effortful control, shyness, and anger) and teacher-child conflict and (b) classroom instructional and emotional support as moderators of associations between temperament and teacher-child conflict. Children (N = 104) were enrolled in 23…

Fulfilling Reform's Promise: The Need To Expand the Vision of Education in the South.

ERIC Educational Resources Information Center

BellSouth Foundation, Inc. Atlanta, GA.

This study explored the role of philanthropy in educational reform. A survey of 22 educators with links to the southern United States was conducted to identify educational needs and to solicit ideas for educational improvement. Priorities redefined by the BellSouth Foundation in response to survey findings include supporting educators to meet…

The Role of Preschool Relational and Physical Aggression in the Transition to Kindergarten: Links with Social-Psychological Adjustment

ERIC Educational Resources Information Center

Gower, Amy L.; Lingras, Katherine A.; Mathieson, Lindsay C.; Kawabata, Yoshito; Crick, Nicki R.

2014-01-01

Research Findings: The transition to kindergarten has important ramifications for future achievement and psychosocial outcomes. Research suggests that physical aggression may be related to difficulty during school transitions, yet no studies to date have examined the role of relational aggression in these transitions. This article examines how…

Investigating a Link between Pre-Calculus Students' Uses of Graphing Calculators and Their Understanding of Mathematical Symbols

ERIC Educational Resources Information Center

Kenney, Rachael H.

2014-01-01

This study examined ways in which students make use of a graphing calculator and how use relates to comfort and understanding with mathematical symbols. Analysis involved examining students' words and actions in problem solving to identify evidence of algebraic insight. Findings suggest that some symbols and symbolic structures had strong…

Brain-Based Teaching Strategies for Improving Students' Memory, Learning, and Test-Taking Success

ERIC Educational Resources Information Center

Willis, Judy

2007-01-01

The past two decades have provided extraordinary progress in our understanding of the nature of learning. Never before have neuroscience and classroom instruction been so closely linked. Now, educators can find evidence-based neuroimaging and brain-mapping studies to determine the most effective ways to teach, as advances in technology enable…

Explaining Why Early-Maturing Girls Are More Exposed to Sexual Harassment in Early Adolescence

ERIC Educational Resources Information Center

Skoog, Therése; Bayram Özdemir, Sevgi

2016-01-01

In this study, we tested two competing explanations of the previously established link between early female puberty and sexual harassment in early adolescence. The sample included 680 seventh-grade Swedish girls (M[subscript age] = 13.40, SD = 0.53). Findings revealed that looking more sexually mature and being sexually active mediated the link…

Relative Immaturity and ADHD: Findings from Nationwide Registers, Parent- and Self-Reports

ERIC Educational Resources Information Center

Halldner, Linda; Tillander, Annika; Lundholm, Cecilia; Boman, Marcus; Långström, Niklas; Larsson, Henrik; Lichtenstein, Paul

2014-01-01

Background: We addressed if immaturity relative to peers reflected in birth month increases the likelihood of ADHD diagnosis and treatment. Methods: We linked nationwide Patient and Prescribed Drug Registers and used prospective cohort and nested case-control designs to study 6-69 year-old individuals in Sweden from July 2005 to December 2009…

Explaining the Gap in Charter and Traditional Public School Teacher Turnover Rates

ERIC Educational Resources Information Center

Stuit, David A.; Smith, Thomas M.

2012-01-01

This study uses national survey data to examine why charter school teachers are more likely to turnover than their traditional public school counterparts. We test whether the turnover gap is explained by different distributions of factors that are empirically and theoretically linked to turnover risk. We find that the turnover rate of charter…

Social Capital for College: Network Composition and Access to Selective Institutions among Urban High School Students

ERIC Educational Resources Information Center

Hill, Lori Diane; Bregman, Allyson; Andrade, Fernando

2015-01-01

This study examines the relationship between networks that provide high school students with "social capital for college" (SCFC) and their access to selective institutions. It also explores the link between racial disparities in access to selective colleges and the composition of students' SCFC networks. Findings indicate that while…

Function-Based Modification of Check-In/Check-Out to Influence Escape-Maintained Behavior

ERIC Educational Resources Information Center

Kilgus, Stephen P.; Fallon, Lindsay M.; Feinberg, Adam B.

2016-01-01

Prior research has suggested Check-In/Check-Out (CICO) effectiveness is linked to the function of problem behavior. Though effective for students whose misbehavior occurs to gain attention, findings are equivocal for behavior that occurs to escape academic tasks. The purpose of this study was to therefore evaluate a modification to CICO, wherein…

Correlations among Jamaican 12th-Graders' Five Variables and Performance in Genetics

ERIC Educational Resources Information Center

Bloomfield, Deen-Paul; Soyibo, Kola

2008-01-01

This study was aimed at finding out if the level of performance of selected Jamaican Grade 12 students on an achievement test on the concept of genetics was satisfactory; if there were statistically significant differences in their performance on the concept linked to their gender, self-esteem, cognitive abilities in biology, school-type and…

How Much of a "Running Start" Do Dual Enrollment Programs Provide Students?

ERIC Educational Resources Information Center

Cowan, James; Goldhaber, Dan

2015-01-01

We study a popular dual enrollment program in Washington State, "Running Start" using a new administrative database that links high school and postsecondary data. Conditional on prior high school performance, we find that students participating in Running Start are more likely to attend any college but less likely to attend four-year…

Appearance Concerns and Smoking in Young Men and Women: Going beyond Weight Control

ERIC Educational Resources Information Center

Grogan, Sarah; Hartley, Louise; Conner, Mark; Fry, Gary; Gough, Brendan

2010-01-01

Aim: This study was designed to investigate the link between appearance concerns and smoking in young men and women. Methods: A total of 244, 17-34-year-olds completed the Multidimensional Body-Self Relations Questionnaire Appearance Sub-Scales (MBSRQ-AS). Findings: Smokers scored significantly lower than non-smokers on appearance evaluation and…

Losing out on Both Counts: Disabled Women and Domestic Violence

ERIC Educational Resources Information Center

Thiara, Ravi K.; Hague, Gill; Mullender, Audrey

2011-01-01

The links between disability and domestic violence have been under-examined to date, leading to the marginalisation of disabled women affected by domestic violence in theory, politics, and practice. This paper draws on the findings from the first national study in the United Kingdom of the needs of disabled women experiencing domestic violence and…

Individual Differences in (Non-Visual) Processing Style Predict the Face Inversion Effect

ERIC Educational Resources Information Center

Wyer, Natalie A.; Martin, Douglas; Pickup, Tracey; Macrae, C. Neil

2012-01-01

Recent research suggests that individuals with relatively weak global precedence (i.e., a smaller propensity to view visual stimuli in a configural manner) show a reduced face inversion effect (FIE). Coupled with such findings, a number of recent studies have demonstrated links between an advantage for feature-based processing and the presentation…

TV Fights: Women and Men in Interpersonal Arguments on Prime-Time Television Dramas.

ERIC Educational Resources Information Center

Brinson, Susan L.

1992-01-01

Studies the behaviors of women and men represented in interpersonal arguments in prime-time television dramas. Finds a weak link between actual argument behaviors and those on television, thereby socializing viewers in a manner inconsistent with reality. Suggests that television arguments are guided more by the needs of the medium that a need to…

Trajectories of Female Student's Career Decision between High School and College: Organizationally Separate but Developmentally Linked

ERIC Educational Resources Information Center

Kim, Kyung-Nyun

2012-01-01

This study examined the relationships between experiences in high school, the choice of college majors, and postcollege career decisions among female college students in Korea, applying growth curve modeling. Findings revealed that as students gained college experience, the possibility of a career-related decision increased each year, but slowly.…

Examining Potential Moderators of the Link between Heterosexist Events and Gay and Bisexual Men's Psychological Distress

ERIC Educational Resources Information Center

Szymanski, Dawn M.

2009-01-01

The purpose of this study was to examine (a) the relationship between heterosexist events and psychological distress and (b) the potential moderating roles of social support, avoidant coping, and self-esteem in the relationship between heterosexist events and psychological distress among 210 gay and bisexual men. Findings from the Web-based…

From Fragmented Knowledge to a Knowledge Structure: Linking the Domains of Mechanics and Electromagnetism.

ERIC Educational Resources Information Center

Bagno, Esther; Eylon, Bat-Sheva; Ganiel, Uri

2000-01-01

Describes the MAOF physics education program which is designed to relate large parts of mechanics and electromagnetism to each other via the key concepts of field and potential, while at the same time treat students' conceptual difficulties. Finds that students who studied with the MAOF program significantly improved their physics knowledge…

Information, education, and health behaviors: Evidence from the MMR vaccine autism controversy.

PubMed

Chang, Lenisa V

2018-05-02

In the wake of strong, although later refuted, claims of a link between autism and the measles-mumps-rubella (MMR) vaccine, I examine whether fewer parents immunized or delayed vaccinations for their children and if there was a differential response by mother's education level. Using various controls and a differencing strategy that compares in MMR take-up with other vaccines, I find that the MMR-autism controversy led to a decline in the immediate years and that there were negative spillovers onto other vaccines. I also find evidence that more highly educated mothers responded more strongly to the controversy either by not immunizing their children altogether or, to a lesser degree, delaying vaccination. Moreover, the educational gap was greater in states where there was greater media attention devoted to the controversy. This is consistent with the health allocative efficiency hypothesis whereby part of the education gradient in health outcomes is due to more-educated individuals absorbing and responding to health information more quickly. However, unlike in the United Kingdom, where previous studies find that the gap was eliminated after the link was refuted, the evidence for the United States suggests that the educational gap persisted. Copyright © 2018 John Wiley & Sons, Ltd.

General Strain Theory and Substance Use among American Indian Adolescents.

PubMed

Eitle, Tamela McNulty; Eitle, David; Johnson-Jennings, Michelle

2013-01-01

Despite the well-established finding that American Indian adolescents are at a greater risk of illicit substance use and abuse than the general population, few generalist explanations of deviance have been extended to American Indian substance use. Using a popular generalist explanation of deviance, General Strain Theory, we explore the predictive utility of this model with a subsample of American Indian adolescents from waves one and two of the National Longitudinal Study of Adolescent Health (Add-Health). Overall, we find mixed support for the utility of General Strain Theory to account for American Indian adolescent substance use. While exposure to recent life events, a common measure of stress exposure, was found to be a robust indicator of substance use, we found mixed support for the thesis that negative affect plays a key role in mediating the link between strain and substance use. However, we did find evidence that personal and social resources serve to condition the link between stress exposure and substance use, with parental control, self-restraint, religiosity, and exposure to substance using peers each serving to moderate the association between strain and substance use, albeit in more complex ways than expected.

General Strain Theory and Substance Use among American Indian Adolescents

PubMed Central

Eitle, Tamela McNulty; Eitle, David; Johnson-Jennings, Michelle

2013-01-01

Despite the well-established finding that American Indian adolescents are at a greater risk of illicit substance use and abuse than the general population, few generalist explanations of deviance have been extended to American Indian substance use. Using a popular generalist explanation of deviance, General Strain Theory, we explore the predictive utility of this model with a subsample of American Indian adolescents from waves one and two of the National Longitudinal Study of Adolescent Health (Add-Health). Overall, we find mixed support for the utility of General Strain Theory to account for American Indian adolescent substance use. While exposure to recent life events, a common measure of stress exposure, was found to be a robust indicator of substance use, we found mixed support for the thesis that negative affect plays a key role in mediating the link between strain and substance use. However, we did find evidence that personal and social resources serve to condition the link between stress exposure and substance use, with parental control, self-restraint, religiosity, and exposure to substance using peers each serving to moderate the association between strain and substance use, albeit in more complex ways than expected. PMID:23826511

Linking Individual Creativity to Organizational Innovation

ERIC Educational Resources Information Center

Litchfield, Robert C.; Ford, Cameron M.; Gentry, Richard J.

2015-01-01

We draw on 146 employee-co-worker-supervisor triads from 146 organizations to examine the role of individual perspective-taking and team creative environment in the association between individual creativity and organizational innovation. Adopting an interactionist perspective, we find that the link between individual creativity and organizational…

Feel like you belong: on the bidirectional link between emotional fit and group identification in task groups

PubMed Central

Delvaux, Ellen; Meeussen, Loes; Mesquita, Batja

2015-01-01

Three studies investigated the association between members’ group identification and the emotional fit with their group. In the first study, a cross-sectional study in a large organization, we replicated earlier research by showing that group identification and emotional fit are positively associated, using a broader range of emotions and using profile correlations to measure group members’ emotional fit. In addition, in two longitudinal studies, where groups of students were followed at several time points during their collaboration on a project, we tested the directionality of the relationship between group identification and emotional fit. The results showed a bidirectional, positive link between group identification and emotional fit, such that group identification and emotional fit either mutually reinforce or mutually dampen each other over time. We discuss how these findings increase insights in group functioning and how they may be used to change group processes for better or worse. PMID:26300806

Breaking down the gut microbiome composition in multiple sclerosis.

PubMed

Budhram, Adrian; Parvathy, Seema; Kremenchutzky, Marcelo; Silverman, Michael

2017-04-01

The gut microbiome, which consists of a highly diverse ecologic community of micro-organisms, has increasingly been studied regarding its role in multiple sclerosis (MS) immunopathogenesis. This review critically examines the literature investigating the gut microbiome in MS. A comprehensive search was performed of PubMed databases and ECTRIMS meeting abstracts for literature relating to the gut microbiome in MS. Controlled studies examining the gut microbiome in patients with MS were included for review. Identified studies were predominantly case-control in their design and consistently found differences in the gut microbiome of MS patients compared to controls. We examine plausible mechanistic links between these differences and MS immunopathogenesis, and discuss the therapeutic implications of these findings. Review of the available literature reveals potential immunopathogenic links between the gut microbiome and MS, identifies avenues for therapeutic advancement, and emphasizes the need for further systematic study in this emerging field.

Alexithymia: a further exploration of its nomological network.

PubMed

Vingerhoets, A J; Van Heck, G L; Grim, R; Bermond, B

1995-01-01

The present studies were designed in order to obtain a better understanding of the nomological network of the alexithymia concept. In study I, the links between alexithymia, coping, and self-rated health were explored. As predicted, strong negative correlations were found between alexithymia and the expression of emotions, daydreams and fantasies, and planful and rational actions. Contrary to expectations, no clear associations were found with self-reported health status. In study II, the focus was on links with personality, temperament, and self-reported (susceptibility to) homesickness. Although some correlations reached statistical significance, all were rather modest. The most remarkable finding was the independence of alexithymia and neuroticism. In study III, the associations between alexithymia and aspects of love experiences were examined, again yielding low correlations. It is concluded that alexithymia is relatively independent of temperament and personality. In addition, it is suggested that the association between alexithymia and the experience of positive emotions deserves further exploration.

Quantitative Raman characterization of cross-linked collagen thin films as a model system for diagnosing early osteoarthritis

NASA Astrophysics Data System (ADS)

Wang, Chao; Durney, Krista M.; Fomovsky, Gregory; Ateshian, Gerard A.; Vukelic, Sinisa

2016-03-01

The onset of osteoarthritis (OA)in articular cartilage is characterized by degradation of extracellular matrix (ECM). Specifically, breakage of cross-links between collagen fibrils in the articular cartilage leads to loss of structural integrity of the bulk tissue. Since there are no broadly accepted, non-invasive, label-free tools for diagnosing OA at its early stage, Raman spectroscopyis therefore proposed in this work as a novel, non-destructive diagnostic tool. In this study, collagen thin films were employed to act as a simplified model system of the cartilage collagen extracellular matrix. Cross-link formation was controlled via exposure to glutaraldehyde (GA), by varying exposure time and concentration levels, and Raman spectral information was collected to quantitatively characterize the cross-link assignments imparted to the collagen thin films during treatment. A novel, quantitative method was developed to analyze the Raman signal obtained from collagen thin films. Segments of Raman signal were decomposed and modeled as the sum of individual bands, providing an optimization function for subsequent curve fitting against experimental findings. Relative changes in the concentration of the GA-induced pyridinium cross-links were extracted from the model, as a function of the exposure to GA. Spatially resolved characterization enabled construction of spectral maps of the collagen thin films, which provided detailed information about the variation of cross-link formation at various locations on the specimen. Results showed that Raman spectral data correlate with glutaraldehyde treatment and therefore may be used as a proxy by which to measure loss of collagen cross-links in vivo. This study proposes a promising system of identifying onset of OA and may enable early intervention treatments that may serve to slow or prevent osteoarthritis progression.

Unique Variants in OPN1LW Cause Both Syndromic and Nonsyndromic X-Linked High Myopia Mapped to MYP1.

PubMed

Li, Jiali; Gao, Bei; Guan, Liping; Xiao, Xueshan; Zhang, Jianguo; Li, Shiqiang; Jiang, Hui; Jia, Xiaoyun; Yang, Jianhua; Guo, Xiangming; Yin, Ye; Wang, Jun; Zhang, Qingjiong

2015-06-01

MYP1 is a locus for X-linked syndromic and nonsyndromic high myopia. Recently, unique haplotypes in OPN1LW were found to be responsible for X-linked syndromic high myopia mapped to MYP1. The current study is to test if such variants in OPN1LW are also responsible for X-linked nonsyndromic high myopia mapped to MYP1. The proband of the family previously mapped to MYP1 was initially analyzed using whole-exome sequencing and whole-genome sequencing. Additional probands with early-onset high myopia were analyzed using whole-exome sequencing. Variants in OPN1LW were selected and confirmed by Sanger sequencing. Long-range and second PCR were used to determine the haplotype and the first gene of the red-green gene array. Candidate variants were further validated in family members and controls. The unique LVAVA haplotype in OPN1LW was detected in the family with X-linked nonsyndromic high myopia mapped to MYP1. In addition, this haplotype and a novel frameshift mutation (c.617_620dup, p.Phe208Argfs*51) in OPN1LW were detected in two other families with X-linked high myopia. The unique haplotype cosegregated with high myopia in the two families, with a maximum LOD score of 3.34 and 2.31 at θ = 0. OPN1LW with the variants in these families was the first gene in the red-green gene array and was not present in 247 male controls. Reevaluation of the clinical data in both families with the unique haplotype suggested nonsyndromic high myopia. Our study confirms the findings that unique variants in OPN1LW are responsible for both syndromic and nonsyndromic X-linked high myopia mapped to MYP1.

Neighborhood Influences on Perceived Social Support Among Parents: Findings from the Project on Human Development in Chicago Neighborhoods

PubMed Central

Tendulkar, Shalini A.; Koenen, Karestan C.; Dunn, Erin C.; Buka, Stephen; Subramanian, S. V.

2012-01-01

Background Social support is frequently linked to positive parenting behavior. Similarly, studies increasingly show a link between neighborhood residential environment and positive parenting behavior. However, less is known about how the residential environment influences parental social support. To address this gap, we examine the relationship between neighborhood concentrated disadvantage and collective efficacy and the level and change in parental caregiver perceptions of non-familial social support. Methodology/Principal Findings The data for this study came from three data sources, the Project on Human Development in Chicago Neighborhoods (PHDCN) Study's Longitudinal Cohort Survey of caregivers and their offspring, a Community Survey of adult residents in these same neighborhoods and the 1990 Census. Social support is measured at Wave 1 and Wave 3 and neighborhood characteristics are measured at Wave 1. Multilevel linear regression models are fit. The results show that neighborhood collective efficacy is a significant (ß = .04; SE = .02; p = .03), predictor of the positive change in perceived social support over a 7 year period, however, not of the level of social support, adjusting for key compositional variables and neighborhood concentrated disadvantage. In contrast concentrated neighborhood disadvantage is not a significant predictor of either the level or change in social support. Conclusion Our finding suggests that neighborhood collective efficacy may be important for inducing the perception of support from friends in parental caregivers over time. PMID:22493683

Auditory Hallucinations and the Brain's Resting-State Networks: Findings and Methodological Observations.

PubMed

Alderson-Day, Ben; Diederen, Kelly; Fernyhough, Charles; Ford, Judith M; Horga, Guillermo; Margulies, Daniel S; McCarthy-Jones, Simon; Northoff, Georg; Shine, James M; Turner, Jessica; van de Ven, Vincent; van Lutterveld, Remko; Waters, Flavie; Jardri, Renaud

2016-09-01

In recent years, there has been increasing interest in the potential for alterations to the brain's resting-state networks (RSNs) to explain various kinds of psychopathology. RSNs provide an intriguing new explanatory framework for hallucinations, which can occur in different modalities and population groups, but which remain poorly understood. This collaboration from the International Consortium on Hallucination Research (ICHR) reports on the evidence linking resting-state alterations to auditory hallucinations (AH) and provides a critical appraisal of the methodological approaches used in this area. In the report, we describe findings from resting connectivity fMRI in AH (in schizophrenia and nonclinical individuals) and compare them with findings from neurophysiological research, structural MRI, and research on visual hallucinations (VH). In AH, various studies show resting connectivity differences in left-hemisphere auditory and language regions, as well as atypical interaction of the default mode network and RSNs linked to cognitive control and salience. As the latter are also evident in studies of VH, this points to a domain-general mechanism for hallucinations alongside modality-specific changes to RSNs in different sensory regions. However, we also observed high methodological heterogeneity in the current literature, affecting the ability to make clear comparisons between studies. To address this, we provide some methodological recommendations and options for future research on the resting state and hallucinations. © The Author 2016. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.

Analysis of broadcasting satellite service feeder link power control and polarization

NASA Technical Reports Server (NTRS)

Sullivan, T. M.

1982-01-01

Statistical analyses of carrier to interference power ratios (C/Is) were performed in assessing 17.5 GHz feeder links using (1) fixed power and power control, and (2) orthogonal linear and orthogonal circular polarizations. The analysis methods and attenuation/depolarization data base were based on CCIR findings to the greatest possible extent. Feeder links using adaptive power control were found to neither cause or suffer significant C/I degradation relative to that for fixed power feeder links having similar or less stringent availability objectives. The C/Is for sharing between orthogonal linearly polarized feeder links were found to be significantly higher than those for circular polarization only in links to nominally colocated satellites from nominally colocated Earth stations in high attenuation environments.

Social maturity and theory of mind in typically developing children and those on the autism spectrum.

PubMed

Peterson, Candida C; Slaughter, Virginia P; Paynter, Jessica

2007-12-01

Results of several studies using the Vineland scale to explore links between social behavior and theory of mind (ToM) have produced mixed results, especially for children on the autism spectrum. The present pair of studies developed a psychometrically sound, age-referenced measure of social maturity to explore these issues further. In Study 1, 37 typically developing preschoolers took a battery of standard false belief tests of ToM and were rated by their teachers on a newly developed age-referenced social maturity scale with 7 items. In Study 2, a further group of 43 children aged 4 to 12 years (13 with autism, 14 with Asperger's disorder and 16 with typical development) took part in the same procedure. In Study 1, ToM was found to predict typical preschoolers' social maturity independently of age and verbal maturity. In Study 2, children with autism scored below age-matched and younger typical developers in both ToM and social maturity. Those with Asperger's disorder did well on ToM but poorly on social maturity. Study 2 replicated Study 1's finding (for typical children and for the full sample) that ToM was linked with social maturity independently of age and verbal ability, although the link was not independent of autism diagnosis. Teachers are capable of rating children's social behavior with peers as advanced, on-time or delayed for their age. Suggestive links between these ratings and ToM require further investigation, especially among children on the autism spectrum.

Does maternal employment following childbirth support or inhibit low-income children's long-term development?

PubMed

Coley, Rebekah Levine; Lombardi, Caitlin McPherran

2013-01-01

This study assessed whether previous findings linking early maternal employment to lower cognitive and behavioral skills among middle-class and White children generalized to other groups. Using a representative sample of urban, low-income, predominantly African American and Hispanic families (n = 444), ordinary least squares regression and propensity score matching models assessed links between maternal employment in the 2 years after childbearing and children's functioning at age 7. Children whose mothers were employed early, particularly in their first 8 months, showed enhanced socioemotional functioning compared to peers whose mothers remained nonemployed. Protective associations emerged for both part-time and full-time employment, and were driven by African American children, with neutral effects for Hispanics. Informal home-based child care also heightened positive links. © 2012 The Authors. Child Development © 2012 Society for Research in Child Development, Inc.

Intergenerational Support and Marital Satisfaction: Implications of Beliefs About Helping Aging Parents

PubMed Central

Polenick, Courtney A.; Zarit, Steven H.; Birditt, Kira S.; Bangerter, Lauren R.; Seidel, Amber J.; Fingerman, Karen L.

2016-01-01

Everyday support given to aging parents is a salient aspect of married life that may have implications for marital quality. Among 132 middle-aged couples drawn from Wave 1 of the Family Exchanges Study, we examined the moderating effects of each spouse’s normative and motivational beliefs about helping parents on associations between the frequency of everyday support that wives and husbands gave to their own parents and marital satisfaction. Husbands' more frequent provision of support was linked to wives' greater marital satisfaction when reports of personal rewards linked to helping parents were high for wives or low for husbands. Conversely, wives’ more frequent provision of support was linked to husbands’ lower marital satisfaction when reports of filial obligation were low for husbands or high for wives. Findings highlight the interdependence within couples, and indicate that both spouses' perceptions are important in understanding linkages between intergenerational support and marital satisfaction. PMID:28154427

Opposites attract or attack? The moderating role of diversity climate in the team diversity-interpersonal aggression relationship.

PubMed

Drach-Zahavy, Anat; Trogan, Revital

2013-10-01

This study embraced a unit-level diversity perspective to examine interpersonal aggression, as experienced or witnessed by individual team members. Specifically, our aim was to explore the moderating role of a unit's diversity climate in the link between unit-level surface diversity in terms of ethnicity, sex, age, and tenure, and individual-level perceptions of interpersonal aggression. We tested our hypotheses with 30 nursing units using the Mixed-Linear Model procedure appropriate for nested samples. Results demonstrated that diversity climate moderated the relationships between tenure and ethnic unit diversity and interpersonal aggression, experienced or witnessed among individual team members. Moreover, regardless of the level of diversity climate, age diversity was positively linked to interpersonal aggression, whereas sex diversity was negatively linked to it. These findings imply that the unit's context affects interpersonal aggression and provides important theoretical and practical implications to proactively prevent interpersonal aggression.

What parents know, how they know it, and several forms of adolescent adjustment: further support for a reinterpretation of monitoring.

PubMed

Kerr, M; Stattin, H

2000-05-01

Parental monitoring has been conceptualized as tracking and surveillance but operationalized as knowledge of daily activities. This study tested the tracking and surveillance explanation of why parental knowledge is linked to better adolescent adjustment. Participants were 1,186 14-year-olds in central Sweden and their parents. The results supported and extended a reinterpretation of parental monitoring (H. Stattin & M. Kerr, in press). Across sex and informant, high parental knowledge was linked to multiple measures of good adjustment. But children's spontaneous disclosure of information explained more of these relations than parents' tracking and surveillance efforts did. Parents' control efforts were related to good adjustment only after the child's feelings of being controlled, which were linked to poor adjustment, were partialed out. The findings suggest that parents' tracking and surveillance efforts are not as effective as previously thought.

Dissociative tendencies and facilitated emotional processing.

PubMed

Oathes, Desmond J; Ray, William J

2008-10-01

Dissociation is a process linked to lapses of attention, history of abuse or trauma, compromised emotional memory, and a disintegrated sense of self. It is theorized that dissociation stems from avoiding emotional information, especially negative emotion, to protect a fragile psyche. The present study tested whether or not dissociaters do actually avoid processing emotion by asking groups scoring high or low on the Dissociative Experiences Scale to judge the affective valence of several types of emotional stimuli. Manipulations of valence, modality (pictures or words), task complexity, and personal relevance lead to results suggesting that dissociation is linked to facilitated rather than deficient emotional processing. Our results are consistent with a theory that sensitivity to emotional material may be a contributing factor in subsequent dissociation to avoid further elaboration of upsetting emotion in these individuals. The findings for dissociation further exemplify the influence of individual differences in the link between cognition and emotion. (c) 2008 APA, all rights reserved

The company objects keep: Linking referents together during cross-situational word learning.

PubMed

Zettersten, Martin; Wojcik, Erica; Benitez, Viridiana L; Saffran, Jenny

2018-04-01

Learning the meanings of words involves not only linking individual words to referents but also building a network of connections among entities in the world, concepts, and words. Previous studies reveal that infants and adults track the statistical co-occurrence of labels and objects across multiple ambiguous training instances to learn words. However, it is less clear whether, given distributional or attentional cues, learners also encode associations amongst the novel objects. We investigated the consequences of two types of cues that highlighted object-object links in a cross-situational word learning task: distributional structure - how frequently the referents of novel words occurred together - and visual context - whether the referents were seen on matching backgrounds. Across three experiments, we found that in addition to learning novel words, adults formed connections between frequently co-occurring objects. These findings indicate that learners exploit statistical regularities to form multiple types of associations during word learning.

Effects of adaptive degrees of trust on coevolution of quantum strategies on scale-free networks.

PubMed

Li, Qiang; Chen, Minyou; Perc, Matjaž; Iqbal, Azhar; Abbott, Derek

2013-10-15

We study the impact of adaptive degrees of trust on the evolution of cooperation in the quantum prisoner's dilemma game. In addition to the strategies, links between players are also subject to evolution. Starting with a scale-free interaction network, players adjust trust towards their neighbors based on received payoffs. The latter governs the strategy adoption process, while trust governs the rewiring of links. As soon as the degree of trust towards a neighbor drops to zero, the link is rewired to another randomly chosen player within the network. We find that for small temptations to defect cooperators always dominate, while for intermediate and strong temptations a single quantum strategy is able to outperform all other strategies. In general, reciprocal trust remains within close relationships and favors the dominance of a single strategy. Due to coevolution, the power-law degree distributions transform to Poisson distributions.

Effects of adaptive degrees of trust on coevolution of quantum strategies on scale-free networks

NASA Astrophysics Data System (ADS)

Li, Qiang; Chen, Minyou; Perc, Matjaž; Iqbal, Azhar; Abbott, Derek

2013-10-01

We study the impact of adaptive degrees of trust on the evolution of cooperation in the quantum prisoner's dilemma game. In addition to the strategies, links between players are also subject to evolution. Starting with a scale-free interaction network, players adjust trust towards their neighbors based on received payoffs. The latter governs the strategy adoption process, while trust governs the rewiring of links. As soon as the degree of trust towards a neighbor drops to zero, the link is rewired to another randomly chosen player within the network. We find that for small temptations to defect cooperators always dominate, while for intermediate and strong temptations a single quantum strategy is able to outperform all other strategies. In general, reciprocal trust remains within close relationships and favors the dominance of a single strategy. Due to coevolution, the power-law degree distributions transform to Poisson distributions.

Clarifying the link between childhood abuse history and psychopathic traits in adult criminal offenders

PubMed Central

Dargis, Monika; Newman, Joseph; Koenigs, Michael

2015-01-01

Childhood abuse is a risk factor for the development of externalizing characteristics and disorders, including antisocial personality disorder and psychopathy. However, the precise relationships between particular types of childhood maltreatment and subsequent antisocial and psychopathic traits remain unclear. Using a large sample of incarcerated adult male criminal offenders (n = 183), the current study confirmed that severity of overall childhood maltreatment was linked to severity of both psychopathy and antisocial personality disorder in adulthood. Moreover, this relationship was particularly strong for physical abuse and the antisocial facet of psychopathy. Sexual abuse history was uniquely related to juvenile conduct disorder severity, rather than adult psychopathy or antisocial behaviors. Additionally, there was a significantly stronger relationship between childhood maltreatment and juvenile conduct disorder than between childhood maltreatment and ASPD or psychopathy. These findings bolster and clarify the link between childhood maltreatment and antisocial behavior later in life. PMID:26389621

Flow, affect and visual creativity.

PubMed

Cseh, Genevieve M; Phillips, Louise H; Pearson, David G

2015-01-01

Flow (being in the zone) is purported to have positive consequences in terms of affect and performance; however, there is no empirical evidence about these links in visual creativity. Positive affect often--but inconsistently--facilitates creativity, and both may be linked to experiencing flow. This study aimed to determine relationships between these variables within visual creativity. Participants performed the creative mental synthesis task to simulate the creative process. Affect change (pre- vs. post-task) and flow were measured via questionnaires. The creativity of synthesis drawings was rated objectively and subjectively by judges. Findings empirically demonstrate that flow is related to affect improvement during visual creativity. Affect change was linked to productivity and self-rated creativity, but no other objective or subjective performance measures. Flow was unrelated to all external performance measures but was highly correlated with self-rated creativity; flow may therefore motivate perseverance towards eventual excellence rather than provide direct cognitive enhancement.

Running away from unwanted feelings: culture matters.

PubMed

Su, Jenny C; Wei, Meifen; Tsai, Hsiao-Tien

2014-01-01

Findings from past research have suggested a link between experiential avoidance and expressive suppression. However, there is emerging evidence showing that the suppression of emotional expression may have different meanings depending on the specific cultural context. Taking a cultural perspective, the present study aimed to examine whether the link between experiential avoidance and expressive suppression is comparable or divergent between two cultural groups [i.e., European Americans (EAs) and Chinese (CH)] with different cultural norms surrounding emotional expression. We hypothesised that the positive association between experiential avoidance and expressive suppression typically found among EAs would be attenuated among CH. Furthermore, the observed cultural group difference in the experiential avoidance-suppression link was hypothesised to be mediated by beliefs in emotional self-control. Data from 224 EA college students and 190 CH college students provided a clear pattern of support for our hypotheses. Implications for current theories on experiential avoidance are discussed.

The Division of Household Labor: Longitudinal Changes and Within-Couple Variation.

PubMed

Lam, Chun Bun; McHale, Susan M; Crouter, Ann C

2012-10-01

This study examined how the division of household labor changed as a function of marital duration and whether within-couple variation in spouses' relative power and availability were linked to within-couple variation in the division of labor. On 4 occasions over 7 years, 188 stably married couples reported on their housework activities using daily diaries. Multilevel models revealed that wives' portions of household responsibilities declined over time, and that changes in spouses' relative income and work hours were linked to changes in housework allocation. Wives with husbands who perceived greater marital control, on average, did proportionally more housework, and for couples with husbands who had highly autonomous jobs, changes in spouses' relative psychological job involvement were linked to changes in housework allocation. Findings highlight the importance of understanding household division of labor as a lifespan phenomenon, the distinction between within- versus between-couple associations, and the multidimensional nature of power and availability.

"Like finding a unicorn": Healthcare preferences among lesbian, gay, and bisexual people in the United States.

PubMed

Martos, Alexander J; Wilson, Patrick A; Gordon, Allegra R; Lightfoot, Marguerita; Meyer, Ilan H

2018-05-07

Lesbian, gay, and bisexual (LGB) peoples' healthcare preferences are often developed in response to social and institutional factors that can ultimately deter them from care. Prior qualitative explorations of LGB healthcare preferences have been limited in their ability to identify and compare patterns across age cohort, gender, and race/ethnicity. The current study examines qualitative data from 186 modified Life Story Interviews with three age cohorts of LGB people from New York City, NY, San Francisco, CA, Tucson, AZ, and Austin, TX to understand the factors influencing LGB people's healthcare preferences. Data are analyzed using a directed content analysis approach. Five key themes emerged regarding influences on healthcare preferences: Stigma, provider expertise, identity, service type, and access. Findings suggest that healthcare preferences among LGB people are both complex and closely linked to social changes over time. Healthcare preferences among LGB people are both complex and closely linked to social changes over time. Copyright © 2018 Elsevier Ltd. All rights reserved.