Improving Interstellar Medium Mitigation in Millisecond PulsarTiming Models for Gravitational Wave Detection Sensitivity

NASA Astrophysics Data System (ADS)

Wilson, Robert C.

2018-01-01

This study aims to increase the sensitivity of pulsar timing arrays (PTAs) used by astronomers ofthe North American Nanohertz Observatory for Gravitational Waves (NANOGrav) to detectgravitational waves (GWs). Millisecond pulsars with many epochs of observations will be used todetermine if dispersive, frequency-dependent pulse time-of-arrival (TOA) delays caused by theinterstellar medium (ISM) can be more accurately predicted over numerous frequency channels.This project will contribute to the ongoing work to detect low-frequency GWs using PTAs. Dataused for this study will be from both the 110m telescope at the Green Bank Observatory in WestVirginia and the 305m telescope at the Arecibo Observatory in Puerto Rico.

Challenges in Data Collection and Analysis in Multi-National Experimentation

DTIC Science & Technology

2007-06-01

sampling of personnel when individual interviews would be labor intensive and time consuming. Ideally surveys contribute to the cognitive aspect of...the experimental data for the data collection plan. In addition to gaining data concerning the cognitive aspect , surveys can be used when no other

Bone marrow - mesenchymal stem cells impact on the U937 cells in the presence of staphylococcal enterotoxin B (SEB).

PubMed

Ejtehadifar, Mostafa; Halabian, Raheleh; Ghazavi, Ali; Khansarinejad, Behzad; Mosayebi, Ghasem; Imani Fooladi, Abbas Ali

2018-04-14

The growing resistance against conventional chemotherapy in acute myeloid leukemia (AML) is a noticeable clinical concern. Therefore, many researchers are looking for novel substances to overcome drug resistance in cancer. Staphylococcal enterotoxin B (SEB) is a superantigen (SAg) and a promising compound which has lethal effects on malignant cells. In this unprecedented study, SEB was used against U937 cells in a co-culture system in the presence of human bone marrow-mesenchymal stem cells (hBM-MSCs). The effects of hBM-MSCs on the proliferation and survival of U937 cell line with SEB was assessed using MTT assay and AnnexinV/PI flowcytometry, respectively. Moreover, the expression of IL-6, IL-10, TGF-β, and inhibitor of nuclear factor kappa-B kinase (IKKb) was evaluated by real-time PCR technique. The same experiments were also carried out using hBM-MSCs-conditioned medium (hBM-MSCs-CM). The results showed that SEB reduced the proliferation and survival of U937 cell line, but hBM-MSCs or hBM-MSCs-CM suppressed the effects of SEB. Furthermore, real-timePCR demonstrated that SEB could decrease the expression of IL-6, IL-10, and TGF-β in hBM-MSCs (P < .05), while the production of IKKb was increased in comparison with the control group. These findings help us to have a broader understanding ofthe usage of SEB in the treatment of haematological malignancies, especially if it is targeted against hBM-MSCs to disrupt their supportive effects on malignant cells. © 2018 John Wiley & Sons Australia, Ltd.

Recent Results with Transatlantic GeTT Campaign

DTIC Science & Technology

1999-12-01

which are driven by H-masers. Frequent comparisons between GPS CP and TWSTFT throughout the campaign allow a comparison of the long-term stability of...the two entirely independent techniques. Small discrepancies between the time transfer by GPS CP and the time transfer by TWSTFT have been observed...density for the GeTT values in comparison to the other time-transfer methods: two-way satellite time and frequency transfer ( TWSTFT ) and Circular T

Time, Space, and Mass at the Operational Level of War: The Dynamics of the Culminating Point,

DTIC Science & Technology

1988-04-28

theoretical framework for operational culmination and then examining the theory as reflected in recent history. This paper focuses on the concept of...the paper first examines key definitions and provides a theoretical framework for understanding culmination. Next, it considers the application of the

A Numerical Study of Time-Dependent Wind Forcing Off the West Coast of Portugal, 1987 - 1988

DTIC Science & Technology

1991-06-01

Canary Current off the west coast of the Iberian Peninsula . A short review of the general circulation of the atmosphere and ocean in the vicinity of...the Iberian Peninsula is presented here as an aid to understanding the motivation for this investigation. The atmospheric circulation over the Eastern...the west coast of the Iberian Peninsula (Figures 2 and 3). The seasonal 4 variation in the location, intensity and areal coverage of the Azores High

[A Case of Effective Chemoradiotherapy Using mFOLFOX6 for Locally Advanced Rectal Cancer].

PubMed

Kuga, Yoshio; Kitamura, Shosuke; Mouri, Teruo; Miwata, Tomohiro; Hirata, Yuzoh; Ishizaki, Yasuyo; Hashimoto, Yasutoshi

2017-05-01

We report a case of locally advanced rectal cancer, treated effectively with chemotherapy consisting of mFOLFOX6 combined with radiotherapy. A 63-year-old man was admitted to our hospital in March 2012 for diarrhea and anal and perineal pain. Advanced rectal cancer with invasion ofthe right perineum was diagnosed based on computer tomography(CT) findings. Surgery was performed; however, the rectal cancer was unresectable. A sigmoid colostomy was performed, and a central venous port was implanted. In April 2012, the patient was treated with chemotherapy using 3 courses ofmFOLFOX6 and concurrent radiotherapy. Radiotherapy at 2 Gy/day was administered 25 times(total dose, 50 Gy). After chemoradiotherapy, the patient underwent 3 courses ofmFOLFOX6 as an additional therapy. By June 2012, CT showed resolution ofthe tumor in the right perineum and a marked decrease in the size ofthe primary rectal cancer. Because the patient refused surgery, we started treatment with combination chemotherapy using oral S-1 and intravenous CPT-11 in August 2012. After 18 courses, the treatment was changed to oral administration ofS -1 alone, which was continued for 1 year. The patient remained well without recurrence for 54 months since the original diagnosis. Therefore, chemoradiotherapy with mFOLFOX6 is a possible option for the management of advanced rectal cancer.

Numerical simulation support to the ESA/THOR mission

NASA Astrophysics Data System (ADS)

Valentini, F.; Servidio, S.; Perri, S.; Perrone, D.; De Marco, R.; Marcucci, M. F.; Daniele, B.; Bruno, R.; Camporeale, E.

2016-12-01

THOR is a spacecraft concept currently undergoing study phase as acandidate for the next ESA medium size mission M4. THOR has been designedto solve the longstanding physical problems of particle heating andenergization in turbulent plasmas. It will provide high resolutionmeasurements of electromagnetic fields and particle distribution functionswith unprecedented resolution, with the aim of exploring the so-calledkinetic scales. We present the numerical simulation framework which is supporting the THOR mission during the study phase. The THOR teamincludes many scientists developing and running different simulation codes(Eulerian-Vlasov, Particle-In-Cell, Gyrokinetics, Two-fluid, MHD, etc.),addressing the physics of plasma turbulence, shocks, magnetic reconnectionand so on.These numerical codes are being used during the study phase, mainly withthe aim of addressing the following points:(i) to simulate the response of real particle instruments on board THOR, byemploying an electrostatic analyser simulator which mimics the response ofthe CSW, IMS and TEA instruments to the particle velocity distributions ofprotons, alpha particle and electrons, as obtained from kinetic numericalsimulations of plasma turbulence.(ii) to compare multi-spacecraft with single-spacecraft configurations inmeasuring current density, by making use of both numerical models ofsynthetic turbulence and real data from MMS spacecraft.(iii) to investigate the validity of the Taylor hypothesis indifferent configurations of plasma turbulence

Optimal UAS Assignments and Trajectories for Persistent Surveillance and Data Collection from a Wireless Sensor Network

DTIC Science & Technology

2015-12-24

minimizing a weighted sum ofthe time and control effort needed to collect sensor data. This problem formulation is a modified traveling salesman ...29 2.5 The Shortest Path Problem . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 2.5.1 Traveling Salesman Problem ...48 3.3.1 Initial Guess by Traveling Salesman Problem Solution

Use of the comma

NASA Astrophysics Data System (ADS)

Eremina, Svetlana V.; Gureyev, Vladimir V.

2005-06-01

Use ofthe comma is the most problematic place ofthe English language for the Russian users. Some rules on the comma usage do not work, others are incorrectly formulated. The list of cases of use amounts from a dozen to thirty, and intuition is not the one to rely on. The material for the case analysis has been taken from the most recent grammar manuals compiled by the English-speaking linguists.

Target Detection and Classification Using Seismic and PIR Sensors

DTIC Science & Technology

2012-06-01

time series analysis via wavelet - based partitioning,” Signal Process...regard, this paper presents a wavelet - based method for target detection and classification. The proposed method has been validated on data sets of...The work reported in this paper makes use of a wavelet - based feature extraction method , called Symbolic Dynamic Filtering (SDF) [12]–[14]. The

Integration and Interoperability of Special Operations Forces and Conventional Forces in Irregular Warfare

DTIC Science & Technology

2009-06-12

Phasing Model ......................................................................................................9 Figure 2. The Continuum of...the communist periphery. In a high-intensity conflict, doctrine at the time called for conventional forces to fight the traditional, linear fight...operations and proximity of cross component forces in a non- linear battlespace – Rigid business rules, translator applications, or manual workarounds to

[Culinary art and social change: some remarks].

PubMed

Fischler, C

1976-01-01

The development in France, long a rural country, of a new type of civilization characterized by industrialization, urbanisation and their corollaries threatens (in a real or imaginary way) both the quality of food (standardization, agricultural, industrialization and new toxicological and pollution problems) and the social-cultural signification of the meal (time constraints, convenience food, fast-food restaurants, etc.) particularly among social strata most involved in the new urban way of life. And yet a new interest and appreciation for cooking and culinary art spreads. Gastronomy can be regarded as a social privilege and/or a celebrative break in the course of ordinary meals: the new culinary vogue might well develop in opposition to--rather than in spite of--the onslaught of convenience food. Significantly enough, it is based on a new mythology and, as a consequence, on new aesthetic canons. The new food emphasizes the signs of nature, archaïsm, rurality, exotism (ethnic food) etc. It is also bound to conciliate the art of food and the image of the body imposed by contemporary culture (slimness, eternal youth...).

Report: Science to Support Rulemaking

EPA Pesticide Factsheets

Report #2003-P-00003, November 15, 2002. The rules included in the pilot study were not a representative statistical sample of EPA rules, and we did not identify all ofthe critical science inputs for every rule.

Identification of Two Suppressors of CSG2 Calcium Sensitivity, SCS7 and SUR2, as Genes Encoding Hydroxylases of the Sphingolipid Biosynthetic Pathway of Saccharomyces cerevisiae

DTIC Science & Technology

1997-12-10

process can adjusted by experimental alteration of thyroid status. Hyperthyroidism speeds up the time table while hypothyroidism retards it. When 88... canine kidney MDCK cells. The relative amounts ofthe labeled products can be differentially recovered from the basolateral and apical surfaces of these

Time-Domain Finite Element Analysis of Nonlinear Breakdown Problems in High-Power-Microwave Devices and Systems

DTIC Science & Technology

2015-12-24

simulation of the electromagnetic- plasma interaction and the high-power microwave breakdown in air. Under the high pressure and high frequency condition of...the high-power air breakdown, the physical phenomenon is described using a nonlinearly coupled full-wave Maxwell and fluid plasma system. This...Challenges ........................................................................... 3 3.1.1 Plasma Fluid Model

Viscoelastic Properties of Advanced Polymer Composites for Ballistic Protective Applications

DTIC Science & Technology

1994-09-01

ofthe Damaged Sample 78 Figure 69: Fracture Surface of Damage Area Near the Point of Penetration 79 Figure 70. Closer View ofthe Damaged Area...LIST OF TABLES Table 1. Basic Mechanical Properties of the Materials 6 Table 2. Initial DMA Test Results 23 Table 3. Flexural Three Point Bend... point bend testing was conducted using an Instron 1127 Universal Tester to verify the DMA test method and specimen clamping configuration. Interfacial

40 CFR 798.5195 - Mouse biochemical specific locus test.

Code of Federal Regulations, 2013 CFR

2013-07-01

... percent ofthe treated matings), although some data on control loci can be taken from the study of the... in 1,200,000 control loci screened) are available for comparative purposes. (5) Test chemicals—(i...

40 CFR 798.5195 - Mouse biochemical specific locus test.

Code of Federal Regulations, 2010 CFR

2010-07-01

... percent ofthe treated matings), although some data on control loci can be taken from the study of the... in 1,200,000 control loci screened) are available for comparative purposes. (5) Test chemicals—(i...

40 CFR 798.5195 - Mouse biochemical specific locus test.

Code of Federal Regulations, 2014 CFR

2014-07-01

... percent ofthe treated matings), although some data on control loci can be taken from the study of the... in 1,200,000 control loci screened) are available for comparative purposes. (5) Test chemicals—(i...

40 CFR 798.5195 - Mouse biochemical specific locus test.

Code of Federal Regulations, 2011 CFR

2011-07-01

... percent ofthe treated matings), although some data on control loci can be taken from the study of the... in 1,200,000 control loci screened) are available for comparative purposes. (5) Test chemicals—(i...

40 CFR 798.5195 - Mouse biochemical specific locus test.

Code of Federal Regulations, 2012 CFR

2012-07-01

... percent ofthe treated matings), although some data on control loci can be taken from the study of the... in 1,200,000 control loci screened) are available for comparative purposes. (5) Test chemicals—(i...

USSR Report, Military Affairs, No. 1781.

DTIC Science & Technology

1983-07-21

began. Our forces chased the enemy westward and in 1944 liberated the native land from the aggressors. The combat actions at the concluding stage of...The course of international events in recent times indicates that imperialism primarily American , disregarding history’s lessons, has not dropped...great depth, including strikes made with strategic weaponry " coulSSes0^ countries about deploying m some West European states new American

Impact Of Landfill Closure Designs On Long-Term Natural Attenuation Of Chlorinated Hydrocarbons

DTIC Science & Technology

2002-03-01

chlorinated aliphatic hydrocarbons (CAHs) (i.e., chlorinated solvents) in landfills and landfill- leachate -contaminated groundwater. The project was divided...attenuation rather than expensive leachate collection and treatment systems. At some landfills, surface infiltration may accelerate the leaching of...the “source” and reduce the time required for biological stabilization of the landfilled waste. Recirculation of landfill leachate could also be

An Assessment of Health Literacy Rates in a Sample of Active-Duty Military Personnel at a Major Medical Center

DTIC Science & Technology

2008-01-01

Sandra Bibb - Dr. Diane Padden -Dr. Gloria Ramsey Background - Literacy Defined • Ability to read parts of the Bible , signing name, or completion...For example, individuals in colonial America were considered literate if they could read at least parts ofthe Holy Bible while as recently as 1998...addition, versions ofthe TOFHLA for adolescents and Hebrew speaking individuals have also been developed as well as a REALM version for teenagers. Initial

Every Airman a Fighter

DTIC Science & Technology

2008-01-01

uneven ground. The training is several times a week. Gichin Funakoshi, a Japanese Karate instructor, remarked that combatives training, " ..was like...ofmartial artists visit each ofthe Air Force bases under Ills command. Experts in Aikido, Judo, and Karate demonstrated their arts to the Airmen. Many of...reach, Lieutenant Sijan knocked the guard out with a Karate -strike with his good arm and escaped by crawling away into the jungle. He was soon

ENVIRONMENTAL PROTECTION AGENCY INDOOR AIR QUALITY AND WORKENVIRONMENT STUDY: HEALTH SYMPTOMS AND COMFORT CONCERNS

EPA Science Inventory

In recent years, employees at the three headquarters buildings ofthe U.S. Environmental Protection Agency (EPA) in the Washington,DC, area have expressed concerns about air quality and workenvironment discomforts. n February 1989, a two-stage study ofhealth and comfort concerns a...

Modeling Geometric Arrangements of TiO2-Based Catalyst Substrates and Isotropic Light Sources to Enhance the Efficiency of a Photocatalystic Oxidation (PCO) Reactor

NASA Technical Reports Server (NTRS)

Richards, Jeffrey T.; Levine, Lanfang H.; Husk, Geoffrey K.

2011-01-01

The closed confined environments of the ISS, as well as in future spacecraft for exploration beyond LEO, provide many challenges to crew health. One such challenge is the availability of a robust, energy efficient, and re-generable air revitalization system that controls trace volatile organic contaminants (VOCs) to levels below a specified spacecraft maximum allowable concentration (SMAC). Photocatalytic oxidation (PCO), which is capable of mineralizing VOCs at room temperature and of accommodating a high volumetric flow, is being evaluated as an alternative trace contaminant control technology. In an architecture of a combined air and water management system, placing a PCO unit before a condensing heat exchanger for humidity control will greatly reduce the organic load into the humidity condensate loop ofthe water processing assembly (WPA) thereby enhancing the life cycle economics ofthe WPA. This targeted application dictates a single pass efficiency of greater than 90% for polar VOCs. Although this target was met in laboratory bench-scaled reactors, no commercial or SBIR-developed prototype PCO units examined to date have achieved this goal. Furthermore, the formation of partial oxidation products (e.g., acetaldehyde) was not eliminated. It is known that single pass efficiency and partial oxidation are strongly dependent upon the contact time and catalyst illumination, hence the requirement for an efficient reactor design. The objective of this study is to maximize the apparent contact time and illuminated catalyst surface area at a given reactor volume and volumetric flow. In this study, a Ti02-based photocatalyst is assumed to be immobilized on porous substrate panels and illumination derived from linear isotropic light sources. Mathematical modeling using computational fluid dynamics (CFD) analyses were performed to investigate the effect of: 1) the geometry and configuration of catalyst-coated substrate panels, 2) porosity of the supporting substrate, and 3) varying the light source and spacing on contact time and illuminated catalyst area.

Resource-Bounded Information Acquisition and Learning

DTIC Science & Technology

2012-05-01

candidate features arrive one at a time, and the learner’s task is to select a ‘best so far’ set of features from streaming features. Krause et al...on Artificial Intelligence. [31] Gatterbauer, Wolfgang . Estimating required recall for successful knowledge acquisition from the web. In Proceedings of...the 15th international conference on World Wide Web (New York, NY, USA, 2006), WWW ’06, ACM, pp. 969– 970. [32] Gatterbauer, Wolfgang . Rules of thumb

USSR and Eastern Europe Scientific Abstracts, Geophysics, Astronomy and Space, Number 392.

DTIC Science & Technology

1977-03-15

evaluation of the parameters of the observed field. It is proposed that for models formed from a set of elements as described that the problem of...the differential energy spectra for protons during the time of large flares on the sun. [303] IMPROVEMENT OF AES ORBITAL ELEMENTS Moscow...Leningrad, ULUSHSHENIYE ORBITAL’NYKH ELEMENTOV ISZ (Improvement in the Orbital Elements of an Artificial Earth Satellite), Leningrad Forestry Academy

Beleaguered Muslim Fortresses and Ethiopian Imperial Expansion from the 13th to the 16th Century

DTIC Science & Technology

2008-06-01

year later Emperor Zara Yakob (r. 1433-1468) took the throne of the Ethiopian Empire.84 Sultan Badlay’s area of control roughly covered the Afar plain...101 Ahmed, 2000: 12; Henze, 79-81; Pankhurst, 1982: 62; Iliffe, 59 (Emperor Zara Yakob as part of...the Christian Empire. On the other hand, throughout that time period, the Christian Emperors, particularly Amda Seyon and Zara Yakob, expanded

Aspects of Fair Division,

DTIC Science & Technology

1980-04-01

The Steinhaus Solution of Divide and Choose. The discussion is intended to be essentially nontechnical, relying mostly on heuristic methods of...the Polish mathesna- tician S. Ulam, in the 1930s D31. A short time later Hugo Steinhaus , also of the Polish school, gave the problem its nickname. The...solved for the case where the number of participants is two, by Hugo Steinhaus . The object of the game is to obtain a partition of an object which is

Truck-mounted Area-wide Application of Pyriproxyfen Targeting Aedes aegypti and Aedes albopictus in Northeast Florida

DTIC Science & Technology

2014-12-01

the time and the lower rate of pyriproxyfen applied. Within 2 wk following Spray 2, however, Ae. albopictus collections from the treatment plot...districts/public health agencies. Pyriproxyfen, a juvenile hormone mimic, func- tions as an insect growth regulator (IGR) preventing normal development of...the lower rate of pyriproxyfen applied. Within 2 wk following Spray 2, however, Ae. albopictus collections from the treatment plot averaged

Exacerbation of allergic inflammation in mice exposed to diesel exhaust particles prior to viral infection.

EPA Science Inventory

Background: Viral infections and exposure to oxidant air pollutants are two ofthe most important inducers ofasthma exacerbation. Our previous studies have demonstrated that exposure to diesel exhaust increases the susceptibility to influenza virus infections both in epithelial ce...

A feasibility study on assessing public health impacts of cumulative air pollution reduction activities in a small geographic area

EPA Science Inventory

Background and Objective: The rnain objective ofthis study was to examine the feasibility ofconducting a local (e.g., city level) assessment ofthe public health impacts ofcumulative air pollution reduction activities (a.k.a. accountability) from the federal, state, local and vo...

CAR and PXR-dependent transcriptional changes in the mouse liver after exposure to propiconazole

EPA Science Inventory

Exposure to the conazoles propiconazole and triadimefon but not myclobutanilled to tumors in mice after 2 years. Transcript profiling studies in the livers ofwild-type mice after short-term exposure to the conazoles revealed signatures indicating the involvement ofthe nuclear rec...

Friend or Ally? A Question for New Zealand

DTIC Science & Technology

1991-05-01

Many close observers of the manoeuvring which went on from the time the Lange government took power in July 1984 until George Shultz declared a...d s - - bu t we par t . George P. Shultz Manila, July 1986 ~ ITH THE WORDS, "we part," the Secretary of State for the United States of...the Western alliance. George Shultz’ simple words marked an historic turn- ing point in United States/New Zealand relations and, perhaps even more

The Cyber War: Maintaining and Controlling the Key Cyber Terrain of the Cyberspace Domain

DTIC Science & Technology

2016-06-26

solution strategy to assess options that will enable the commander to realize the Air Force’s cyber mission. Recommendations will be made that will...will present a solution to assist the JFC in achieving cyberspace dominance. Background In the modern world of advanced technology, control of...the solutions are: 1) timely identification of key cyber terrain, 2) accurate mapping of the cyber terrain, 3) defense of key cyber terrain, and 4

Munitions Response Projects Shallow Water Marine UXO Detection Survey - Underwater Survey of Camp Lejeune

DTIC Science & Technology

2011-03-01

following: disturbance of sensitive environments (including wildlife); dredging up potentially contaminated sediments; physical contact with UXO; damaging or...is discussed below. 2.1.1 EM61 System and Sensors The EM61 is a high-resolution time-domain electromagnetic metal detector that is capable of...the position of the tow boat and then try to extrapolate the position of the detector based on cable length and GPS heading. In most cases, the

Analyzing and Assessing Brain Structure with Graph Connectivity Measures

DTIC Science & Technology

2014-05-09

structural brain networks, i.e. determining which regions of the brain are physically connected. Meanwhile, functional MRI ( fMRI ) yields an image of...produced by fMRI is a map of which parts are of the brain are active and which are not at a given time. In creating functional networks, regions of...the brain which often activitate together, i.e., often show up on fMRI as deoxygenated regions together, are considered connected. DTI allows the

Time-Accurate Computations of Free-Flight Aerodynamics of a Spinning Projectile With and Without Flow Control

DTIC Science & Technology

2006-09-01

and cylinders (4, 5, 6). These synthetic jets are active control devices with zero net mass flux and are intended to produce the desired control of...the flow field through momentum effects . Many parameters such as jet location, jet velocity, and actuator frequency can affect the flow control...understanding of the flow physics. Amitay et al. (5) experimentally investigated flow separation control on a cylinder using synthetic jet actuators. Their

Sino-Myanmar Nexus: Regional Impact and US Strategy

DTIC Science & Technology

2013-03-01

purpose of this growth is to expand its influence only in the region, not globally. Myanmar sits at an important geostrategic location that connects the...University says, “Myanmar is the pivot of China’s grand strategy to achieve its economic growth goal.”14 Chinese commodities account for 80 per cent of...the first four months of 2010, China’s exports were four times the amount of those from 6 Myanmar. China is now Myanmar’s largest trading

Abolish the Office of the Secretary of Defense?

DTIC Science & Technology

2007-01-01

should he go, the debate should have been whether we even need the Office of the Secretary of Defense (OSD). It is perhaps time to admit that the great...source is the office itself. Simply put, the Secretary of Defense and his supporting staff are too powerful. The wisdom of the creation and relevance of...the original organization are what need to be reconsidered. The following recommendations are offered for consideration. First, abolish the Office of

Mars Aerobraking Spacecraft State Estimation by Processing Inertial Measurement Unit Data

NASA Technical Reports Server (NTRS)

Jah, Moriba K.; Lisano, Michael E.,, II; Born, George H.; Axelrad, Penina

2006-01-01

Aerobraking is an efficient technique for orbit adjustment of planetary spacecraft, such as Magellan (Venus), Mars Global Surveyor, and Mars Odyssey. Determination of the vehicle state during the aerobraking phase has conventionally been performed using only radiometric tracking data prior to and following the atmospheric drag pass. This approach is sufficiently accurate and timely to meet current mission operational requirements; however, it is expensive in terms of ground support and leads to delayed results because ofthe need for post-drag pass data. This research presents a new approach to estimation of the vehicle state during the atmospheric pass that sequentially incorporates observations from an Inertial Measurement Unit (IMU) and models of the vehicle and environment. The approach, called Inertial Measurements for Aerobraking Navigation (IMAN), is shown to perform at a level comparable to the conventional methods in terms of navigation accuracy and superior to them in terms of availability of the results immediately after completion ofthe pass. Furthermore, the research shows that IMAN can be used to reliably predict subsequent periapsis times and locations over all aerobraking regimes. IMAN also yields accurate peak dynamic pressure and heating rates, critical for a successful corridor control strategy, comparable to navigation team reconstructed values. This research also provides the first instance of the utilization of the Unscented Kalman Filter for the purpose of estimating an actual spacecraft trajectory arc about another planet.

Insurgency in Ancient Times: The Jewish Revolts Against the Seleucid and Roman Empires, 166 BC-73 AD

DTIC Science & Technology

2005-05-26

apocalyptic doctrine. One particular sect of the Essenes was the Qumran which is fairly well known today because they are believed to be the authors of...the Dead Sea Scrolls. The Qumran is believed to have come into existence in the late Hasmonean period and they are illustrative of one of many...Jewish nation. The Qumran also refers to a Teacher of Righteousness, who is a priest and a prophet. Additionally, this individual is referred to in

2011 AFMS Medical Research Symposium Held in National Harbor, Maryland on August 2-4, 2011. Volume 2: Enroute Care and Expeditionary Medicine Track

DTIC Science & Technology

2011-08-01

Wilford Hall Medical Center, Lackland AFB, TX, and a standardized abstraction form was utilized that included the following: age; sex; nature of injury...Limitations • Titere was limited documentation due to the difficulty in interpreting physicians’ handwriting . • Due to time consb·a ints and number of...the occurrence and nature of task saturation during simulated CCATT missions and will provide the groundwork for potential improvements in CCATT

Motion Coordination and Adaptation Using Deception and Human Interactions

DTIC Science & Technology

2016-11-18

evolves an interface (front) by embedding it as a hyper - surface in a higher dimension, where time is the augmented dimension. Automatic handling of...the open- loop system trajectories. The results are depicted in Fig. 32. From the shape of the value function in Fig. 32(b) it is seen that the value is...estimate of the value function only over the area of the state space visited by the sampled (open- loop ) trajectories. In that sense, the areas not

Enhanced Detection of Orthogonal Radar Waveforms Using Time-Frequency and Bi-Frequency Signal Processing Techniques

DTIC Science & Technology

2008-09-01

using the principle of pheromones . The termite senses the pheromone , which tells him to gather up dirt in its mouth and deposit it where the scent of...the pheromone is the strongest. The termite gathers dirt and moves to the location of the strongest scent and deposits the mud there. As this...process is repeated by a number of termites all leaving their own contribution of pheromone at the scene, the autocatalytic effect takes over. This

An RSM Study of the Effects of Simulation Work and Metamodel Specification on the Statistical Quality of Metamodel Estimates

DTIC Science & Technology

1994-03-01

optimize, and perform "what-if" analysis on a complicated simulation model of the greenhouse effect . Regression metamodels were applied to several modules of...the large integrated assessment model of the greenhouse effect . In this study, the metamodels gave "acceptable forecast errors" and were shown to

Team Member Training Manual.

DTIC Science & Technology

1998-07-01

by those who studied human behavior. Behaviorists such as Abraham Maslow , and Frederick Herzberg developed theories of motivation which share much of...the same kinds of things as Theory Y. Theory Y as well as the theories of Maslow and Herzberg offer ways for managers to practice "pull" concepts of...29 Maslow ’s Hierarchy of Needs

The response of salmon populations to geomorphic measurements at three scales

Treesearch

M.D. Bryant; R.D. Woodsmith

2009-01-01

Protocols to assess stream channel response to disturbances often focus on physical aspects ofthe stream at the reach scale without measurements of fish populations. In this study, estimates of juvenile salmon abundance in 511 habitat units within 25 reaches of 12 streams were made over 4 years and juxtaposed with...

CDDIS: NASA's Archive of Space Geodesy Data and Products Supporting GGOS

NASA Technical Reports Server (NTRS)

Noll, Carey; Michael, Patrick

2016-01-01

The Crustal Dynamics Data Information System (CDDIS) supports data archiving and distribution activities for the space geodesy and geodynamics community. The main objectives of the system are to store space geodesy and geodynamics related data and products in a central archive, to maintain information about the archival of these data,to disseminate these data and information in a timely manner to a global scientific research community, and provide user based tools for the exploration and use of the archive. The CDDIS data system and its archive is a key component in several of the geometric services within the International Association of Geodesy (IAG) and its observing systemthe Global Geodetic Observing System (GGOS), including the IGS, the International DORIS Service (IDS), the International Laser Ranging Service (ILRS), the International VLBI Service for Geodesy and Astrometry (IVS), and the International Earth Rotation and Reference Systems Service (IERS). The CDDIS provides on-line access to over 17 Tbytes of dataand derived products in support of the IAG services and GGOS. The systems archive continues to grow and improve as new activities are supported and enhancements are implemented. Recently, the CDDIS has established a real-time streaming capability for GNSS data and products. Furthermore, enhancements to metadata describing the contents ofthe archive have been developed to facilitate data discovery. This poster will provide a review of the improvements in the system infrastructure that CDDIS has made over the past year for the geodetic community and describe future plans for the system.

An Examination of the Selection Criteria Used in the Architect-Engineer Selection Process of Air Force Base Civil Engineers.

DTIC Science & Technology

1987-09-01

overall goal of hiring highly qualified firms on a fair basis. In conducting this research and writing its report of findings, I have benefited greatly... it . Introduction................... . . ... .. .. ..... Overview.................. . . ... .. .. ... Background........ ...... .. .. ...... Focus of...the focus of the study, its purpose and justification, its specific objective, and the scope of the study’s application. Background In recent years

Susquehanna River Basin Flood Control Review Study

DTIC Science & Technology

1980-08-01

22 Archeological and Historial Resources 25 Biological Resources 25 Social -Economic History 28 Contemporary Social -Economic Setting 29 Development and... social needs of the people. The study was initiated in 1963 with the formation of the Susquehanna River Basin Coordinating Committee consisting of...the basin. Social -Economic History The early history of the Susquehanna River Basin was influenced by the Susquehanna River as a source of

The National Interests of Singapore: A Background Study for United States Policy

DTIC Science & Technology

1993-12-01

this as an electoral 3,lbid, pp. 313-4. 29b -care tactic, outlining all manner ot disaster that might be evpected should a freak election result in an...D E F N\\ S E ......................................................................................................- 22 _. Results ofthe 25 Year...3 0 9 2. Government Incentive Programs ...................................................... 312 3. Results of Incentive

Within the Walls: An Analysis of Sexual Harassment and Sexual Coercion at Naval Consolidated Brig Miramar

DTIC Science & Technology

2006-12-01

accused guard’s sentencing hearing] out of fear that something might happen to her child .” (Human Rights Watch, 1998, p.26) In their study of...the rules are being followed Camera system was a good idea Hanibal Lector face masks Conjugal visits, porn . Training the staff, hold them

Studies of Infection and Dissemination of Rift Valley Fever Virus in Mosquitoes

DTIC Science & Technology

1990-05-01

study of Rift Valley fever ( RVF ) virus in mosquitoes. During this year, we~havelcarrled out: (1) Immuno- cytochemical and ultrastructurai studies of...the proventriculus of adult, fkmale CuIex o infected with RVF virus. (2) irlmunocytochomical studies of the salivary glands and other tissues in...3) work on the development of an Immunogold procedure for InL.si labelling of RVF virlons In -_ + 20. DISTRIBUTION /AVAILABILITY OF ABSTRACT 21

[Factors of anxiety and autonomic tonus in senior preschool children from Magnitogorsk].

PubMed

Ingel', F I; Stepanova, A A; Stepanova, O P; Legostaeva, T B; Koganova, Z I; Kozlova, O B

2013-01-01

In the paper there are presented the results of a study of anxiety and balance ofparts of autonomous nervous system in healthy children 5-7 years old, residing in different parts of Magnitogorsk. It is shown that state of heightened and high alert was shown to be more common among children living on the left bank of the Urals river around the Magnitogorsk Metallurgical Integrated Plant. In these children an imbalance in the work of the parts of the autonomic nervous system was detected more frequently, at that shifts were observed mainly in the direction to ergotropic tone. At the same time balanced work of the parts of the autonomic nervous system was observed more frequently in children living on the right bank of the Urals river. Discovered psychosomatic features of examined children turned out to be associated with both the social characteristics of family lifestyle and the emotional stress of parents, and the contents of some organic compounds in total snow samples collected in the territories of kindergartens which they attended. One ofthe most significant results ofthe work we consider the detection of a correlation relationship between emotional stress of parents and activity of key enzymes in their children, reflecting the protective and adaptive reactions of the organism. On the basis of these and previously obtained data, we suggest that social and psychological factors of the family are not only a potential source of maladaptation of the child, but, probably, can have an impact on the stability and sensitivity of the genome of children.

Time Delay of Terrestial Light Pulses Propagating through Clouds to Satellite Systems

DTIC Science & Technology

1980-07-07

des Lichtes in Truben Medien, inshesondere Nebel and Wolken", Beitr. z. Phys. d. f. Atm. 11 69-74, 1923. 8. Mecke, R., "Uber Zerstreuung und Beugung... des Lichtes durch Nebel und Wolken", Ann d. Phys. 65, 257-273, 1921. 9. Stewart, H., "The Diffusion of Light Through an Overcast", University of...the pulse. The degree to which such a system would be de - graded can be estimated from the pulse shape one would expect from a delta function light

Deficient BIM Expression as a Mechanism of Intrinsic and Acquired Resistance to Targeted Therapies in EGFR-Mutant and ALK-Positive Lung Cancers

DTIC Science & Technology

2015-08-01

AWARD NUMBER: W81XWH-13-1-0226 TITLE: Deficient BIM Expression as a Mechanism of Intrinsic and Acquired Resistance to Targeted Therapies in...REPORT TYPE Annual 3. DATES COVERED 1 Aug 2014 - 31 Jul 2015 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Deficient BIM Expression as a Mechanism of...the time of resistance. We are now using these patient-derived cell lines to assess BIM levels and apoptotic response to next-generation inhibitors

Theory of Spectroscopy and Dynamics in Laser-Irradiated Adspecies-Surface Systems.

DTIC Science & Technology

1986-07-01

integrodifferential equation of the Volterra type. P is the occupation probability of the vibrational state Is> of the adbond, and the memory kernrl KS(r...Incorporate the phonon (p) and the radiation (r) terms : K I= K 5 , + . F~rxa Debye model of~the solid, we have obtained He phonon portions K P1 in closed...of interest. Thus, KSS,(t)= OSS,(t) + K ( (3) The second term on the right-hand side is time-independent. If it were a delta function also, we would

Time and Frequency Dependent Behavior of a Two Dimensional Electron Gas at Long Wavelengths.

DTIC Science & Technology

1985-11-05

lated by techniques which are basically similar to those employed 5-10 T y c e sfor the three dimensional case. The dynamic properties have also received...2m, Vk 2re 2/k, where m and e are, respectively, the electron mass and charge, 1 = . Our system is imposed under an external perturbing potential of...the following form: H = 3’ Pk(t) Pk e i’t (2) where -. is the Fourier comp6nent of the external electric field sufficiently small as to permit the use

The President and the Intelligence Community: The Importance of the Relationship

DTIC Science & Technology

2017-12-01

intelligence failures. Case studies are used to establish the character of the relationships between Presidents John F. Kennedy, George H. W. Bush, and...contribute to a working relationship strong enough to mitigate the risk of intelligence failures. Case studies are used to establish the character of...the president’s relationship with the IC as a whole?2 Then, through case study analysis, asks does a positive working relationship between the

Quality Improvement Analysis of the Air Force Aircraft Maintenance and Munitions Officers Course

DTIC Science & Technology

1994-09-01

participant. 82nd Training Group, Sheppard AFB, TX. Personal communications, 10 August. Bryman , A. 1989. Research methods and organizational studies...1991. Business research methods . Boston, MA: Richard D. Irwin, Inc. Frisbee, G.J. 1988. A study of the technical versus administrative orientation of...the stakeholders of the system. Qualitative research can provide a perspective that many quantitative methodologies cannot ( Bryman , 1989: 139- 141

Immunological Study of the O-Antigens of Streptomycin-Dependent Mutants of Salmonella

DTIC Science & Technology

1974-10-23

AD/A-O00 361 IMMUNOLOGICAL STUDY OF THE O-ANTIGENS OF STREPTOMYCIN-DEPENDENT MUTANTS OF SALMONELLA L. S. Edvabnaya, et al Foreign Technology Division...U. S. Air Force SREPORT TITLE IMMUNOLOGICAL STUDY OF THE 0-ANTIGENS OF STREPTOMYCIN-DEPENDENT MUTANTS OF SALMONELLA 4 DCESCRIPTIVIE NOTES (?T’pe of...THE O-ANTIGENS OF STREPTOMYCIN-DEPENDENT MUTANTS OF SALMONELLA By: L. S. Yedvabnaya, Ye. S. Stanislavskiy, and V. V. Sergeyev Englihs pages: 10 Source

Some Instruments Used by Division 10, NDRC at Dugway Proving Ground for Continuous Recording of Micrometeorological Conditions

DTIC Science & Technology

1945-10-01

I. INTRODUCTION One of the original objectives of the NDRC Laboratory at Dugwoy Proving Ground was to study and assess the effect of...the results of the experiment should include information from more than one looation on the target, or else a study at one location of the varia...forecasts or in other micrometeorologioal studies . In addition it has proved useful in measurements on wind profiles« temperature profiles, and

Enzymatic catalysis of the Diels-Alder reaction in the biosynthesis of natural products.

PubMed

Oikawa, Hideaki; Tokiwano, Tetsuo

2004-06-01

Recent studies on enzymes catalyzing the Diels- Alder reaction. often named "Diels-Alderases", clearlydemonstrated the involvement of this synthetically useful reaction in the biosynthesis of natural products.This review covers natural Diels-Alder type cycloadducts. synthetic efforts on the chemical feasibility ofthe biosynthctic Diels - Alder reaction and a brief history of studies on Diels-Alderases. In addition,reaction mechanisms of artificial and natural Diels--Alderases are discussed.

The Role of Pituitary Beta-Endorphin in the Attenuation of Nociception

DTIC Science & Technology

1986-08-28

204 X TABLES Table # Title 1 Effects of naloxone, fentanyl , diazepam and placebo on plasma norepinephrine levels (pgjml). 2 Lack of...the clinical CRH study. 4 Experimental design and sampling schedule for the clinical dexamethasone study. 5 Effects of naloxone (NAL), fentanyl ...FEN), diazepam (DZP) and placebo (PLBO) on circulating levels of iB-END. 6 7 8 9 10 11 12 Effects of naloxone (NAL), fentanyl (FEN), diazepam

A Study of Data Entry Keyboards: The 4 x 4 Keypad.

DTIC Science & Technology

1985-06-01

Touch-Tone is a registered trademark of Bell Telephone Laboratories, Inc. OThe 0S-3 Event Recorder is a registered trademark of...the standard of • the industry--the Touch-Tone® telephone with a key arrangement adopted after considerable research by human factors engineers at Bell ...calculator manufacturers, a series of * important studies was performed by Peininger (5) of the Bell Laboratories * to establish the keypad array for

Socialization in Work Organizations.

DTIC Science & Technology

1982-02-01

this view comes from several very large sample studies in which 78 both birth order and family size are negatively related to intelligence of...The development of identification with an occupation. American Journal of Sociology, 1956, 61. 289-298. Belmont, L., & Marolla, F.A. Birth order , family...Press, 1966. Breland, H.M. Birth order , family configuration and verbal achievement. Child Development, 1974, 45, 1011-1019. Brett, J.M., & Werbel

Aethaperazinum,

DTIC Science & Technology

1979-11-02

patients who are not sensitive tc the effect /action of aminazine. PHARMAGOLOGICAL STUDY. Aethaperazinum - dihydrocdloride of 2-chloro- {[4-(8-hydroxyetnyl...that te new neuroplegic substance has the wide spectrum of activity, similar to the spectrum of the effect /action of aminazina. Page 147. All means of...the aminazine; some DOC = 791� PAGE 3 mans of the peripheral effect /action in aethaperazinus are expressed to a lesser degree. Anti-emetic effect

Regeneration of Musculoskeletal Tissues by Prolonged Low-Grade Inflammation

DTIC Science & Technology

2011-10-01

grade inflammation around a pure collagen based scaffold on implantation into the rabbit patellar tendon. Additionally, the cross-sectional areas of...the tendons treated with the implant were about 40% greater compared to the sham- operated controls. In the current study, we hypothesized that soft...was implanted into the rat patellar tendon using a minimally invasive technique and the inflammation was blocked using liposomal clodronate. The

Culicoides Biting Midges (Diptera: Ceratopogonidae) of Kenya

DTIC Science & Technology

1990-03-01

Culicoides. Two of these viruses cause human disease, including Shuni virus (Nigeria, South Af- rica) and Oropouche virus (Trinidad, Brazil, Co...in the field and for virus iso- lation and transmission studies. Taxonomic History and Group Systematics Khamala & Kettle (1971) gave an account of...the Animal Virus Research Institute, Pirbright. Richard Lane of the British Museum (Natural History), London, assisted with the !nm cd type

Drugs and Air Operations

DTIC Science & Technology

2001-06-01

in research alternative hypnotic free of such medico- legal establishments which directly support the military, restraints. In this context zolpidem is...1997) from the Reporto Medicina deprivation have been studied by the Walter Reed Aeronautica e Spatiale, Aeroporto Pratica di Mare, Army Institute of...the adverse effects of the compound at years, but in view of the constraint imposed by the appropriate dose rather than on the primary medico- legal

Predation of Karluk River sockeye salmon by coho salmon and char

USGS Publications Warehouse

McIntyre, J.D.; Reisenbichler, R.R.; Emlen, J.M.; Wilmot, R.L.; Finn, J.E.

1988-01-01

The number of sockeye salmon, Oncorhynchus nerka, in Alaska's Karluk River (Fig. 1) declined from millions to thousands during the early part of the present century. Rounsefell (1958) discussed alternative explanations for the decline including a general loss offertility ofthe system as the number of salmon carcasses declined, competition, overfishing, subtle changes in climate, and predation; he concluded that the combined effect of predation and fishing was the most probable explanation. Later, Van Cleave and Bevan (1973) suggested that the weir constructed in the river each year to facilitate counting the fish as they entered the system was the most probable cause ofthe decline. Itprevented free movement of both adults and juveniles in the river. All of these hypotheses remain as potential explanations for the decline

Higher speed freight truck : structural analysis.

DOT National Transportation Integrated Search

2013-10-01

Sharma & Associates, Inc. (SA) had previously (20052009) developed a higher speed freight truck under sponsorship ofthe : Federal Railroad Administration (FRA). Under the current contract, SA wastasked with developing performance requirements : fo...

Fragility Analysis of Concrete Gravity Dams

NASA Astrophysics Data System (ADS)

Tekie, Paulos B.; Ellingwood, Bruce R.

2002-09-01

Concrete gravity dams are an important part ofthe nation's infrastructure. Many dams have been in service for over 50 years, during which time important advances in the methodologies for evaluation of natural phenomena hazards have caused the design-basis events to be revised upwards, in some cases significantly. Many existing dams fail to meet these revised safety criteria and structural rehabilitation to meet newly revised criteria may be costly and difficult. A probabilistic safety analysis (PSA) provides a rational safety assessment and decision-making tool managing the various sources of uncertainty that may impact dam performance. Fragility analysis, which depicts fl%e uncertainty in the safety margin above specified hazard levels, is a fundamental tool in a PSA. This study presents a methodology for developing fragilities of concrete gravity dams to assess their performance against hydrologic and seismic hazards. Models of varying degree of complexity and sophistication were considered and compared. The methodology is illustrated using the Bluestone Dam on the New River in West Virginia, which was designed in the late 1930's. The hydrologic fragilities showed that the Eluestone Dam is unlikely to become unstable at the revised probable maximum flood (PMF), but it is likely that there will be significant cracking at the heel ofthe dam. On the other hand, the seismic fragility analysis indicated that sliding is likely, if the dam were to be subjected to a maximum credible earthquake (MCE). Moreover, there will likely be tensile cracking at the neck of the dam at this level of seismic excitation. Probabilities of relatively severe limit states appear to be only marginally affected by extremely rare events (e.g. the PMF and MCE). Moreover, the risks posed by the extreme floods and earthquakes were not balanced for the Bluestone Dam, with seismic hazard posing a relatively higher risk.

Groupthink: A Significant Threat to the Homeland Security of the United States

DTIC Science & Technology

2014-12-01

Jin Nam Choi and Myung Un Kim, details a study that examines groupthink’s effect on 30 organizational teams faced with impending crises. The study...40sessionmgr114&hid=115. 13 Jin Nam Choi and Myung Un Kim, “The Organizational Application of Groupthink and its Limitations in Organizations,” Journal of...the past to provide a mechanism that will help identify, manage, and mitigate this psychological phenomenon in the homeland security enterprise

Elytroderma disease reduces growth and vigor, increases mortality of Jeffrey pines at Lake Tahoe Basin, California

Treesearch

Robert R Scharpf; Robert V. Bega

1981-01-01

A disease of Jeffrey pines (Pinus jeffreyi Grev. and Balf.) at Lake Tahoe Basin, California, caused by Elytrodenna disease (Elytroderma deformans) was studied for 7 years after a severe outbreak ofthe fungus in 1971. Among 607 Jeffrey pines on six plots, about one-half were heavily infected and about one-half were moderately or lightly infected in 1971. No uninfected...

New Ebb-Tidal Delta at an Old Inlet, Shark River Inlet, New Jersey

DTIC Science & Technology

2011-01-01

examine interacting beach and inlet processes and to test numerical simulation models for predicting morphology change at inlets. This study was...intertidal, oyster-encrusted Figure 4. A) Shark River Inlet, February-March 1920, post early construction (1915), but during rehabilitation of...the original State-built, curved jetties; B) Shark River Inlet, 23 January 1933, post construction of curved jetties and land reclamation of the flood

Semiotics and the Study of Occupational and Organizational Cultures.

DTIC Science & Technology

1983-06-01

traces its roots to the teachings of Ferdinand de Saussure (1966), the father of modern structural - . - linguistics, and to the pragmatic philosophy of...For example, Saussure conceived ofthe sign as composed of the two parts (the signifier and the signified), while Pierce advocated a tripartate concept...published lectures of Saussure (1966) but also in the writings of Barthes (1967), Hawkes (1977), and Culler (1976). For the Piercian perspective, Morris

Off-Range Beaked Whale Studies (ORBS): Baseline Data and Tagging Development for Northern Bottlenose Whales (Hyperoodon ampulatus) off Jan Mayen, Norway

DTIC Science & Technology

2015-09-30

02.003’N, 07°01.981’W) To be recovered in 2016 Ranging code #08D1; releasing code #0803 In collaboration with Rune Hansen of the University of...the animal with PTT 134760 was tracked moving all the way south to the Azores Archipelago. Figure courtesy of Rune Hansen. Objective 4. conduct

Acute and Chronic Stress: The Effects of Loss of Control

DTIC Science & Technology

1996-07-31

stressor affecting the health and well-being of the unemployed and their families. This study was designed to test how loss of control associated with...status: short-term ( unemployed for less than two months); long-term ( unemployed for longer than two months); and, employed controls. Perceptions of...the laboratory stressor resulting in performance deficits and helpless behavior. As predicted. compared to the other two groups. long-term unemployed

Quercetin manipulates the expression of genes involved in the reactive oxygen species (ROS) processin chicken heterophils.

PubMed

Nambooppha, Boondarika; Photichai, Kornravee; Wongsawan, Kanreuthai; Chuammitri, Phongsakorn

2018-06-06

Chicken heterophils generate reactive oxygen species (ROS) molecules to defend against invading pathogens. The present study examined effects of quercetin on chicken heterophils. Heterophils were stimulated with PBS, 50 μM quercetin (QH), PMA or Escherichia coli (EC) and the resulting intracellular ROS molecules were determined. Flow cytometry results showed that cells stimulated with QH, PMA and EC had a higher ROS production. Increases in intracellular ROS molecules were identified in all treatment groups by fluorescence microscopy. Determination of the ability of quercetin to manipulate mRNA expression of ROS subunits was assessed using real-time RT-PCR. Quercetin and other stimulants up-regulated the majority of genes involved in ROS production: CYBB (NOX2), NCF1 (p47 phox ), NCF2 (p67 phox ), NOX1 and RAC2. The antioxidant property of QH was explored by measuring mRNA expression of CAT and SOD1. The data indicate increased levels of CAT with all treatments; however, only QH attenuated the expression ofthe SOD1 gene. To further investigate the effects of ROS-driven inflammation or cell death, IL6, CASP8, and MCL1 genes were preferentially tested. The inflammatory gene (IL6) was profoundly down-regulated in the QH- and PMA-treated groups while EC induced a strikingly high IL6 expression level. Investigation of the known apoptotic (CASP8) and anti-apoptotic (MCL1) genes found down-regulation of CASP8 in the QH- and PMA-treated groups which were contradicted to the MCL1 gene. In conclusion, quercetin can enhance ROS production by regulating the expression of genes involved in ROS production as well as in subsequent processes.

Hazing DEOCS 4.1 Construct Validity Summary

DTIC Science & Technology

2017-08-01

Hazing DEOCS 4.1 Construct Validity Summary DEFENSE EQUAL OPPORTUNITY MANAGEMENT INSTITUTE DIRECTORATE OF...the analysis. Tables 4 – 6 provide additional information regarding the descriptive statistics and reliability of the Hazing items. Table 7 provides

75 FR 65060 - Advisory Committee on Prosthetics and Special-Disabilities Programs; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-21

...-of-the- art prosthetics and the associated rehabilitation research, development, and evaluation of... injuries, blindness or visual impairments, loss of extremities or loss of function, deafness or hearing...

JPRS Report, Science & Technology. Europe: Economic Competitiveness

DTIC Science & Technology

1991-02-22

effective technology transfer, • workshops aimed at potential marketing, • actions to promote synergistic effects with cross- fertilization of...the syncytial virus; treatment of sexually-transmissible diseases, such as prevention of recidivous vulvovaginal candidiases ; and parasitological

US Army Evaluations: A Study of Inaccurate and Inflated Reporting

DTIC Science & Technology

2012-04-26

decisions such as promotions directly impacting the careers of tens of thousands of the Anny’s leaders, both officer and NCO, has few equals in the...accurate, and equitable perfonnance ratings throughout the Army.13 Many ofthe revisions were caused by the inability of selection boards to discern a...should be : assigned a numerical percentage; superior equals top ten percent, excellence equals top twenty- five percent, success equals top fifty

Carbohydrate Supplementation and Immune Responses After Acute Exhaustive Resistance Exercise

DTIC Science & Technology

2008-01-01

247 International Journal of Sport Nutrition and Exercise Metabolism, 2008, 18, 247-259 © 2008 Human Kinetics , Inc. Carlson is with the Dept. of...the men who participated in the study. References Bachle, T.R., & Earle, R.W. (2000). Essentials of strength and conditioning. Champaign, IL: Human ... Kinetics . Dill, D.B., & Costill, D.L. (1974). Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. Journal of

Comparison of PIDC and IDC Event Bulletins

DTIC Science & Technology

2000-09-01

statistic as it was not used in the processing at the two data centers. The differences for hydro acoustic and infra sonic stations follow the pattern of...the seismic stations. For two of the infra sonic stations (ISM and IS59) data was only available at the PIDC during the study period. Software...defining phases, ndef. For the whole period the percentage of matched events is over 90% for ndef larger than five. Hydroacoustic and infrasonic

Shipboard Electrical System Modeling for Early-Stage Design Space Exploration

DTIC Science & Technology

2013-04-01

method is demonstrated in several system studies. I. INTRODUCTION The integrated engineering plant ( IEP ) of an electric warship can be viewed as a...which it must operate [2], [4]. The desired IEP design should be dependable [5]. The operability metric has previously been defined as a measure of...the performance of an IEP during a specific scenario [2]. Dependability metrics have been derived from the operability metric as measures of the IEP

European Science Notes Information Bulletin Reports on Current European/ Middle Eastern Science

DTIC Science & Technology

1988-08-01

problems, and infrastructure and in- terfacing requirements. Development of Finite Element Software for Transputer-Based Parallel Processors ...Introduction will it be possible to harness these processors together to work on a common problem. The feasibility study at the UK’s Kent University for One of...the many problems in harnessing the power development of a distributed supercomputer is being of a large number of processors on a single problem is

Geostrophic Turbulence in the Frequency-Wavenumber Domain: Eddy-Driven Low-Frequency Variability

DTIC Science & Technology

2014-01-01

in ASFMRS. Previous studies of oceanic frequency– wavenumber spectra include Wunsch and Stammer (1995), Chelton and Schlax (1996), Farrar (2008...ASFMRS. However, the realistic eddying ocean model utilized here is the Hy- brid Coordinate Ocean Model (HYCOM; Chassignet et al. 2007 ), in place of...the Naval Research Laboratory (NRL) Layered Ocean Model (NLOM; Hurlburt and AUGUST 2014 ARB I C ET AL . 2051 Thompson 1980; Shriver et al. 2007 ) used

An Annotated Bibliography on Tactical Map Display Symbology

DTIC Science & Technology

1989-08-01

failure of attention to be focused on one element selectively in filtering tasks where only that one element was relevant to the discrimination. Failure of...The present study evaluates a class of models of human information processing made popular by Broadbent . A brief tachistoscopic display of one or two...213-219. Two experiments were performed to test Neisser’s two-stage model of recognition as applied to matching. Evidence of parallel processing was

Improving Polar Motion Predictions Using AAM χ1 and χ2 Forecasts

NASA Astrophysics Data System (ADS)

Ratcliff, J. T.; Gross, R. S.

2017-12-01

The uncertainty in our knowledge of the Earth's changing orientation in space is a majorsource of error in tracking and navigating interplanetary spacecraft. Because the Earth'sorientation changes rapidly and unpredictably, measurements must be acquired frequentlyand processed rapidly in order to meet the near-real-time Earth orientation requirements ofthe interplanetary spacecraft navigation teams. The Kalman Earth Orientation Filter (KEOF)is used to combine GPS polar motion and LOD measurements, Very Long Baseline Interferometry(VLBI) polar motion and UT measurements, along with other publicly available Earth orientationmeasurements including proxy measurements such as atmospheric angular momentum (AAM),in order to generate and deliver the required polar motion and UT1 Earth orientation parametersto the spacecraft navigation teams. Short-term predictions of the EOPs are produced in order toprovide the navigation teams with an uninterrupted series of Earth orientation parameters. WhileAAM 𝜒3 forecasts are used as a proxy LOD forecast to improve UT1 predictions, Polar Motionpredictions had not been similarly treated. In order to evaluate the effectiveness off AAM 𝜒1 and 𝜒2forecasts on improving Polar Motion predictions we reprocessed one year (Jan.-Dec. 2015) of EOP measurementsto include the 𝜒1 and 𝜒2 components of National Centers for Environmental Prediction (NCEP)AAM daily 5-day forecasts. Inclusion of AAM 𝜒1 and 𝜒2 forecasts into EOP predictions was foundto improve the accuracy of the Polar Motion 5-day predictions by 33% in the X-component and 34% in the Y-component.

A Numerical Study of Vortex Dynamics of Flexible Wing Propulsors

DTIC Science & Technology

2009-11-23

of validation. Figure 2 shows the streamline plot of the cylinder for Reynolds number of 40. The coefficient of drag and blob length is calculated to...Large amplitude lunate tail theory of fish locomotion. Journal of Fluid Mechanics 74, 161–182. Clough, R. W. & Penzein, J. 1993 Dynamics of...the swimming of slender fish . Journal of Fluid Mechanics 9, 305–317. Lighthill, M. J. 1970 Aquatic animal propulsion of high hydrodynamical efficiency

Special Plans and Operations: Assessment of Allegations Concerning Traumatic Brain Injury Research Integrity in Iraq

DTIC Science & Technology

2011-03-31

protocols conducted in Iraq. His office had been designated by the 1 A research protocol is a formal document detailing the study methodology and the...Human Research Protections Program plan requires scientific peer review to ensure that research is scientifically sound in its design and methods, and...ofthe approved research protocol and IRB minutes, revealed that there was no mention of "active rehabilitation and exercise" under the design

The Effects of Liberalizing World Agricultural Trade: A Review of Modeling Studies

DTIC Science & Technology

2006-06-01

agricultural policy issues. Like the LINKAGE model analysis, the GTAP-AGR model analysis uses version 6.05 of the GTAP database with a base year of...the 2006 study—fully liberal- izing agricultural policy in equal increments from 2005 through 2010—would increase world economic welfare in 2015 by...Burfisher, ed., Agricultural Policy Reform in the WTO—The Road Ahead, Agricultural Economic Report No. 802 (U.S. Department of Agriculture, Economic

A Crew Exposure Study. Volume II. At Sea.

DTIC Science & Technology

1982-03-15

work was prepared as an account of government- sponsored work. Neither the United States, nor the U. S . Coast Guard, nor any person acting on behalf of...the U. S . Coast Guard (A) Makes any warranty or representation: expressed or implied, with respect to the accuracy, completeness, or usefulness of the...method or process dis- closed in this report. As usedin the above, "persons acting on behalf of the U. S . Coast Guard" includes any employee or

Q-Space Scattering Power Laws and the Interior Fields of Particles

DTIC Science & Technology

2016-02-12

SECURITY CLASSIFICATION OF: This work studied the relationship between light scattered by particles of any shape and the interior field of that...Release; Distribution Unlimited UU UU UU UU 12-02-2016 7-Jul-2014 6-Apr-2015 Final Report: Q-space Scattering Power Laws and the Interior Fields of...the Army position, policy or decision, unless so designated by other documentation. 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS (ES) U.S

A Numerical Wind Tunnel Study of Viscous-Inviscid Interaction

DTIC Science & Technology

1992-01-01

partially successful. In Task 1 we devised surface boundary conditions for the multiscale model including effects of roughness and blowing. This work tied up ...directed at cleaning up some loose ends in de- veloping the Wilcox multiscale model (see Appendix R). The most significant issue was the development of...the following correlation between SR and k , will reproduce measured effects of sand-grain roughness for values of k up to about 400. ( k, ញ SiR (42

Studies in Intelligence. Volume 53, Number 2, June 2009

DTIC Science & Technology

2009-06-01

intellig s of foreign states and similar organization lligence has both a defensive mission—prot n—and an offensive mission—finding out ir aims.–Office of...the fundamental question of how homas Powers The Basics of CI Differences in the conceptions of their missions, as well as the political, social...as a distinct subject area,” but he goes on to say that traditional international relations ( IR ) theory on “structural realism” provides a

Role of the Functional State of the Hypothalamus in Bioelectric Reactions of the Cerebral Cortex to Radiation,

DTIC Science & Technology

The effect of subjection of the hypothalamus to electrocoagulation in the area of the mamillary bodies on the bioelectric activity and reactivity of...the cerebral cortex exposed to radiation was studied. Rabbits were irradiated on the 10th day after electrocoagulation . Immediately after... electrocoagulation , a decline in the excitability and functional activity of cortical neurons in the posterior section of the cortex and a decrease in the

Evaluating the Military Potential of a Developing Nation’s Space Program: A Case Study of Brazil

DTIC Science & Technology

1991-09-01

decided to create Empresa Brasileira de Aeronautica (EMBRAER). EMBRAER was a mixed public/private sector aircraft company. The government was given 51% of...the space launch market. Solid fuel missiles are easier to hide, transport , and fire than are liquid fuel systems like the Scud. These advantages make...In 1965, The Brazilian Air Force Ministry created the Space Activities Institute (IAE-Instituto de Atividades Espaciais). In 1966, the United States

The Distribution and Predictive Value of Bishop Scores in Nulliparas between 37 and 42 Weeks Gestation

DTIC Science & Technology

2011-01-01

to include body mass index or the presence of gestational diabetes and other medical conditions. However, to our knowledge the strongest predictor of...The distribution and predictive value of Bishop scores in nulliparas between 37 and 42 weeks gestation PETER E. NIELSEN, BOBBY C. HOWARD, TAMI...accuracy of Bishop scores was evaluated to predict cesarean delivery (CD) in nulliparas between 37 and 42 weeks gestation . Study design. Subjects underwent

Remediation System Evaluation, Ellis Property Superfund Site

EPA Pesticide Factsheets

The Ellis Property Superfund Site is located in a rural area of Burlington County, New Jersey. Most ofthe land at the site has not been developed. However, there is a building in a fenced area that is used tohouse the remedial system..

Nonlinear Acoustics.

DTIC Science & Technology

1984-09-01

1, 1983-November 30, 1984 3 I. ANNUAL SUMMARY REPORT A. Nonlinear Properties of the Fluoroperovskites (Cubic Symmnetry) In addition to measurement of...the nonlinear properties of the fluoroperovskites CsCdF3 and KZnF 3 at room temperature published last year [N. A. Breazeale, J. Philip, A

Resource Management in Peace and War

DTIC Science & Technology

1990-04-01

the relatively uncon- strained use of available military forces and weapons, including nuclear, chemical, biological , or other weapons capable of...The Zero-Sum Solution, 1985 (New York: Simon & Schuster, 1985), p. 333. 50. John Naisbitt, Megatrends (New York: Warner Books, 1984), pp. 53-60. 51

Multiple Source DF (Direction Finding) Signal Processing: An Experimental System,

DTIC Science & Technology

The MUltiple SIgnal Characterization ( MUSIC ) algorithm is an implementation of the Signal Subspace Approach to provide parameter estimates of...the signal subspace (obtained from the received data) and the array manifold (obtained via array calibration). The MUSIC algorithm has been

The alignment of immediate health effects of multi-hour exposure periods

EPA Science Inventory

Objective: Exposure to [me airborne particulate matter (PM2.5) has been associated with cardiovascular outcomes, including acute effects on endothelial dysfunction. With such immediate effects, the choice ofthe exposure timeframe may be a critical factor. This analysis compares t...

Notification: Evaluation of Cherryvale, Kansas National Zinc Company site

EPA Pesticide Factsheets

July 12, 2012. The purpose of this memorandum is to notify you that the OIG plans to conduct a review ofthe process followed by EPA Region 7 in the handling of site related contamination at the Cherryvale, Kansas National Zinc Company site.

High Resolution Studies of the Structure of the Solar Atmosphere

DTIC Science & Technology

1993-08-04

two-fluid solar wind model", submitted to J. Geophys. Res., August 1993. M. B. Arndt, S. R. Habbal, and M. Karovska , "Discrete and localized nature of...the variable emission from active regions", submitted to Solar Phys., August 1993. M. Karovska and F. Blundell, "The fine structure at the limb in a...coronal hole", submitted to Ap. J, August 1993. M. Karovska , M. Arndt and S. R. Habbal, "Spatial and temporal variability of the emission at the limb

History of the Army Ground Forces. Study Number 24. History of the Mountain Training Center

DTIC Science & Technology

1948-01-01

yaws, pius the knowledge of mevoral experienced mountaineers and skiers in the Office of the Quartermster General. On 20 May 1943 the Mountain and... skier ? Or will a mini- of knowledge and proficiency be sufficient? These are the questions that tad to be answered before the large-scale trainiag of...the prerogatives of Army co-nand were subordinated to the superior knowledge and skills of the mountaineering experts who had come into the Army7

Southeast Asia’s Relations with Taiwan, 2000-2016: An Assessment of Vietnam and Singapore

DTIC Science & Technology

2017-09-01

were considered good during Taiwan president Lee Teng-hui’s terms (1988–2000) with robust economic ties and de facto diplomatic relations. Studies of...the post -Lee period have described a state of deteriorated relations between Taiwan and Southeast Asian countries when Chen Shui-bian succeeded Lee...Taiwan set up its de facto embassy in Ho Chi Minh City in 1992, and Vietnam set up its own representative office in Taipei in 1993. Vietnam continued to

Maturing Defense Support of Civil Authorities and the Dual Status Commander Arrangement Through the Lens of Process Improvement

DTIC Science & Technology

2015-04-01

strategic leaders and provide well-being education and support by developing self -awareness through leader feedback and leader resiliency. The School of...The concepts, philosophy, and theory of strategy; and, • Other issues of importance to the leadership of the Army. Studies produced by civilian and...ARRANGEMENT THROUGH THE LENS OF PROCESS IMPROVEMENT Ryan Burke Sue McNeil April 2015 The views expressed in this report are those of the authors

Psychophysiological Studies II. Performance and Physiological Response in Coronary Prone and Noncoronary Prone Individuals.

DTIC Science & Technology

1986-01-30

Cyborg BL907 heart rate monitor. A pressure sensitive transducer was placed over the radial artery of the left arm to measure HR in beats per minute...measurement was obtained with a Cyborg Thermal P642. Temperature was recorded by a thermistor placed on the dorsal surface of the middle finger of...the left hand (second phalanx) and was displayed to .01 degrees Farenheit. Electromyogram activity was measured with a Cyborg P303. Measurements (to .1

Studies of Weak, ELF Electromagnetic Fields Effects on the Early Embryonic Development

DTIC Science & Technology

1988-12-29

characters: - General aspect: stage; size of the embryo; size of the head relatively to the trunk. - Head : morphology of the skull; development of...the eyes; size and morphology of the beak; size of the neck . - Trunk: morphology of the vertebral column; development of the tail; closure of thorax and...mishandled, the orientation of the embryo was not taken into account. As indicated in Fig. 7, the head -tail axis orientation of an embryo was North (N

EFFECTS OF GESTATIONAL ETHANOL INHALATION ON SENSORY FUNCTION IN RATS.

EPA Science Inventory

Ethanol-blended gasoline entered the market in response to demand for domestic renewable energy sources, which may result in exposure to ethanol vapors in combination with other volatile gasoline constituents. To begin an assessment ofthe risks of exposure to this mixture, we eva...

19 CFR 210.12 - The complaint.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE... or effect of restraining or monopolizing trade and commerce in the United States under section 337(a)(1)(A)(iii), include a description ofthe trade and commerce affected. (7) Include a description of...

A Large Drift Detector Array Lunar Orbiter Spectrometer

NASA Technical Reports Server (NTRS)

Gaskin, Jessica A.; Ramsey, Brian; Rebak, Pavel; De Geronimo, Gianluigi; Chen, Wei; Li, Zheng; Carini, Gabriella; Keister, Jeffrey; Siddons, Peter D.; Pinelli, Donald

2009-01-01

Measurement of-rays from the surface of objects can tell us about the chemical composition. Absorption of radiation causes characteristic fluorescence from material being irradiated. By measuring the spectrum ofthe radiation and identifying lines in the spectrum, the emitting element (s) can be identified.

Iron and Steel Industry Training Board

ERIC Educational Resources Information Center

Riley, Alvan D.

1974-01-01

The British iron and steel industry training board has developed a training approach called investment appraisal of training. This approach is a forward-looking appraisal in which the estimated costs ofthe proposed training activity are balanced against benefits accruing in fi nancial terms from improved performance. (DS)

Pulse!! The Virtual Clinical Learning Lab and Center of Excellence

DTIC Science & Technology

2011-08-01

environments, physiological assets and case-authoring tools using state- of-the art technologies common to the videogame industry but here appropriated...interior processes (e.g., fluid dynamics) are beyond the current reach of the videogame industry. c. Concise Accomplishments (limit 200 words/170

Results from the hydrodynamic element of the 1994 entrapment zone study in Suisun Bay

USGS Publications Warehouse

Burau, J.R.; Gartner, J.W.; Stacey, M.

1998-01-01

The entrapment zo as long been considered an important region of the San Francisco estuary. It has been the subject of several previous studies, and its location has been suggested as an index of condition of the estuarine ecosystem.A close correlate of this location, X2 1, is now used as a management objective on the basis that X2 is correlated with the abundance or survival of several estuarine-dependent species. X2 is a crude tool to use for this purpose, but it can be refined only through improved understanding of the various mechanisms underlying these correlations. These mechanisms probably differ among species, but for species resident in and near the entrapment zone, the correlation with X2 may be due to variations in intenSity oftrapping mechanisms with pOSition of the entrapment zone. Therefore, it is worthwhile to investigate these trapping mechanisms, the nature of the entrapment zone as habitat, and the responses of the entrapment zone to changes in X2 or outflow from the Sacramento-San Joaquin Delta. Studies ofthe entrapment zone ofthe San Francisco estuary have been conducted in springs of 1994, 1995, and 1996. These studies have been funded by the Interagency Ecological Program and conducted by scientists from IEP member agencies, the Romberg Tiburon Center for Environmental Studies, Bodega Marine Laboratory, and the University of California at Santa Cruz. This report presents results from 1994, a low-flow year. Subsequent reports will describe results from 1995 and 1996 and highlight differences among years. This report is organized in chapters that comprise more-or-Iess independent papers, with an introductory chapter for the entire study. This Executive Summary presents highlights of the overall study plan and summarizes the major findings.

PFAA Days III Meeting Report and Highlights

EPA Science Inventory

The Office of Research and Development (ORD) at the U.S. Environmental Protection Agency (U.S. EPA) sponsored a symposium on perfluoroalkyl acids (PFAAs) on June 8-10, 2010 at the Research Triangle Park, NC. The goals ofthe symposium were to share and review the latest research ...

Clean Break

ERIC Educational Resources Information Center

Peterson, Erin

2011-01-01

An interim president has to perform a particularly difficult balancing act. He or she shoulders the burdens from--or legacy of--the previous president and must also provide a foundation of stability for the new president. Throughout the process, effective communication--both internally and externally--is critical to ensuring a smooth transition.…

Hypothesis testing with computational modeling: linking aromatase inhibition with plasma vitellogenin dynamics in fathead minnows

EPA Science Inventory

Fadrozole inhibits aromatase (CYP19A), a key enzyme that converts testosterone to estradiol (E2). In fish, E2 concentrations control hepatic synthesis ofthe glycolipoprotein vitellogenin (VTG), an egg yolk precursor protein essential to oocyte development and larval survival. Whe...

Biography of Dr. John L. Fryer

USGS Publications Warehouse

Fryer, John L.

2001-01-01

from his laboratory at Oregon State University (OSU) has spanned the disciplines of virology, parasitology, bacteriology, cell biology, immunology and fish physiology, resulting in more than 200 publications, two patents and recognition as one ofthe world's leading centres for research on infectious diseases of salmonid fish.

Overview of Constitutional Challenges to NSA Collection Activities and Recent Developments

DTIC Science & Technology

2014-04-01

acquisition of foreign intelligence information went “well beyond garden -variety law enforcement” purposes.106 Furthermore, the court found a high degree of...the affected person may challenge the lawfulness of the acquisition.”). 127 See Charlie Savage , Federal Prosecutors, in a Policy Shift, Cite

Al Qaeda and Fourth Generation Warfare as its Strategy

DTIC Science & Technology

2008-01-01

and materia ~ as well as money, from one point ofthe non- linear battlefield to another, thereby giving more flexibility to obtain the right materials...translated by Griffith, Samuel B., On Guerilla Warfare, (1937),21-22. 14 Bodansky, Yossef, Bin Laden The Man Who Declared War on America (Rocklin: Prima

Flat Panel Displays for Medical Monitoring Systems

DTIC Science & Technology

2001-10-25

filter prevents light from passing (figure 2). FLAT PANEL DISPLAYS FOR MEDICAL MONITORING SYSTEMS A. Cebrián, J. Millet , I. García Department of...The touch screen is placed over the flat panel display as a filter (figure 10) and allows user interfaces based in direct finger touch (figure 11

Developmental Effects of Perfluorononanoic acid in the Mouse Are Dependent on Peroxisome Proliferator-Activated Receptor-alpha

EPA Science Inventory

Perfluorononanoic acid (PFNA) is one ofthe perfluoroalkyl acids found in the environment and in tissues of humans and wildlife. Prenatal exposure to PFNA negatively impacts survival and development of mice and activates the mouse and human peroxisome proliferator-activated recept...

Ocean Surface Wave Optical Roughness: Innovative Polarization Measurement

DTIC Science & Technology

2007-09-30

Jessup and Phadnis , 2005) have been reported. 1 Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden for the collection of...the open sea, Journal of Physical Oceanography, 16, 290-297. Jessup, A.T. & Phadnis , K.R. 2005 Measurement of the geometric and kinematic properties

Development of a method for estimating emissions from oil and gas production sites utilizing remote observations

EPA Science Inventory

There is a lack of information on emissions of ozone precursors, hazardous air pollutants, and greenhouse gases from oil and gas production operations, and measurement of these emissions presents many challenges. Assessment is complicated by the fugitive nature ofthe emissions, v...

Real-time evaluation and visualization of learner performance in a mixed-reality environment for clinical breast examination.

PubMed

Kotranza, Aaron; Lind, D Scott; Lok, Benjamin

2012-07-01

We investigate the efficacy of incorporating real-time feedback of user performance within mixed-reality environments (MREs) for training real-world tasks with tightly coupled cognitive and psychomotor components. This paper presents an approach to providing real-time evaluation and visual feedback of learner performance in an MRE for training clinical breast examination (CBE). In a user study of experienced and novice CBE practitioners (n = 69), novices receiving real-time feedback performed equivalently or better than more experienced practitioners in the completeness and correctness of the exam. A second user study (n = 8) followed novices through repeated practice of CBE in the MRE. Results indicate that skills improvement in the MRE transfers to the real-world task of CBE of human patients. This initial case study demonstrates the efficacy of MREs incorporating real-time feedback for training real-world cognitive-psychomotor tasks.

Science Objectives and Rationale for the Radiation Belt Storm Probes Mission

NASA Technical Reports Server (NTRS)

Mauk, B.H.; Fox, Nicola J.; Kanekal, S. G.; Kessel, R. L.; Sibek, D. G.; Ukhorskiy, A.

2012-01-01

The NASA Radiation Belt Storm Probes (RBSP) mission addresses how populationsof high energy charged particles are created, vary, and evolve in space environments,and specifically within Earths magnetically trapped radiation belts. RBSP, with a nominallaunch date of August 2012, comprises two spacecraft making in situ measurements for atleast 2 years in nearly the same highly elliptical, low inclination orbits (1.1 5.8 RE, 10).The orbits are slightly different so that 1 spacecraft laps the other spacecraft about every2.5 months, allowing separation of spatial from temporal effects over spatial scales rangingfrom 0.1 to 5 RE. The uniquely comprehensive suite of instruments, identical on the twospacecraft, measures all of the particle (electrons, ions, ion composition), fields (E and B),and wave distributions (dE and dB) that are needed to resolve the most critical science questions.Here we summarize the high level science objectives for the RBSP mission, providehistorical background on studies of Earth and planetary radiation belts, present examples ofthe most compelling scientific mysteries of the radiation belts, present the mission design ofthe RBSP mission that targets these mysteries and objectives, present the observation andmeasurement requirements for the mission, and introduce the instrumentation that will deliverthese measurements. This paper references and is followed by a number of companionpapers that describe the details of the RBSP mission, spacecraft, and instruments.

NASA study backs SSTO, urges shuttle phaseout

NASA Astrophysics Data System (ADS)

Asker, James R.

1994-03-01

A brief discusion of a Congressionally ordered NASA study on how to meet future US Government space launch needs is presented. Three options were examined: (1) improvement ofthe Space Shuttle; (2) development of expendable launch vehicles (ELVs); and (3) development of a single-stage-to-orbit (SSTO), manned vehicle that is reusable with advanced technology. After examining the three options, it was determined that the most economical approach to space access through the year 2030 would be to develop the SSTO vehicle and phase out Space Shuttle operations within 15 years and ELVs within 20 years. Other aspects of the study's findings are briefly covered.

High Energy Astrophysics Tests of Lorentz Invariance and Quantum Gravity Models

NASA Technical Reports Server (NTRS)

Stecker, Floyd W.

2011-01-01

High-energy astrophysics observations provide the best possibilities to detect a very small violation of Lorentz invariance such as may be related to the structure of space-time near the Planck scale of approximately 10-35 m. I will discuss here the possible signatures of Lorentz invariance violation (LIV) from observations of the spectra, polarization, and timing of gamma-rays from active galactic nuclei and gamma-ray bursts. Other sensitive tests are provided by observations ofthe spectra of ultrahigh energy cosmic rays and neutrinos. Using the latest data from the Pierre Auger Observatory one can already derive an upper limit of 4.5 x 10(exp -23) to the amount of LIV at a proton Lorentz factor of -2 x 10(exp 11). This result has fundamental implications for quantum gravity models. I will also discuss the possibilities of using more sensitive space based detection techniques to improve searches for LIV in the future.

The Effective Use of U.S. Coast Guard Security Zones in Countering Unlawful Transnational Protests at Sea

DTIC Science & Technology

2009-01-01

Clinton’s Cuba Policy, August 1994," Presidential Studies Quarterly 28, no. 1, Winter 1998, 215. 24 The Sinking ofthe ൕ de Marzo " Tugboat on 13 July...seeking to bring attention to their cause with extreme measures.23 The sinking ofTREZE DE MARZO became an incident on which to focus future protests...Before the mass migration and subsequent agreement of 1994, Cuban migrants hijacked the Cuban tug TREZE DE MARZO on July 11, 1994 in an attempt to escape

Martins Fork Lake Sedimentation Study. Hydraulic Model Investigation

DTIC Science & Technology

1988-09-01

30 per- cent of the 1.67 acre-ft/square mile, or 0.50 acre-ft/square mile was selected to represent the new expected sediment inflow rate (USAED...Cross Sec- tion Coordinates" (GEDA). The GEDA files were converted to HEC-6 format. Roughness 15. Manning’s n values were selected for each stem of...the network. The values selected are shown in Table 2. Table 2 * Manning’s n Values Network n Value Martins Fork main stem 0.040 Crane Creek 0.045 Board

A Qualitative Study of the European Trucking Industry and Logistics Strategies Using the United States Motor Carrier Industry as a Guide

DTIC Science & Technology

1992-09-01

UNITED STATES MOTOR CARRIER INDUSTRY AS A GUIDE THESIS David W. Butler Andrew P. Wilhelm Captain, USAF Captain, USAF AFIT/GLM/LSM/92S-7 Approved for...UNITED STATES MOTOR CARRIER INDUSTRY AS A GUIDE THESIS Presented to the Faculty of the School of Systems and Logistics of the Air Force Institute of...THE EUROPEAN TRUCKING INDUSTRY AND LOGISTICS STRATEGIES USING THE UNITED STATES MOTOR CARRIER INDUSTRY AS A GUIDE I. Introduction General Issue The

War on Film: Military History Education. Video tapes, Motion Pictures, and Related Audiovisual Aids

DTIC Science & Technology

1987-01-01

Lusitania to the battles at Verdun, Gallipoli, and the Argonne, we view the breadth of the great war. D-16. Part 1. The Summer of Sarajevo Part 2. Clash of...the Generals Part 3. The Doomed Dynasties Part 4. Atrocity 1914 Part 5. They Sank the Lusitania Part 6. Verdun the Inferno Part 7. Battle of Jutland... Lusitania . This study of the sinking of the Lusitania in World War I emphasizes the prevailing political, social, and economic climate both in Europe and

Safety analytics for integrating crash frequency and real-time risk modeling for expressways.

PubMed

Wang, Ling; Abdel-Aty, Mohamed; Lee, Jaeyoung

2017-07-01

To find crash contributing factors, there have been numerous crash frequency and real-time safety studies, but such studies have been conducted independently. Until this point, no researcher has simultaneously analyzed crash frequency and real-time crash risk to test whether integrating them could better explain crash occurrence. Therefore, this study aims at integrating crash frequency and real-time safety analyses using expressway data. A Bayesian integrated model and a non-integrated model were built: the integrated model linked the crash frequency and the real-time models by adding the logarithm of the estimated expected crash frequency in the real-time model; the non-integrated model independently estimated the crash frequency and the real-time crash risk. The results showed that the integrated model outperformed the non-integrated model, as it provided much better model results for both the crash frequency and the real-time models. This result indicated that the added component, the logarithm of the expected crash frequency, successfully linked and provided useful information to the two models. This study uncovered few variables that are not typically included in the crash frequency analysis. For example, the average daily standard deviation of speed, which was aggregated based on speed at 1-min intervals, had a positive effect on crash frequency. In conclusion, this study suggested a methodology to improve the crash frequency and real-time models by integrating them, and it might inspire future researchers to understand crash mechanisms better. Copyright © 2017 Elsevier Ltd. All rights reserved.

The Abbott RealTime High Risk HPV test is a clinically validated human papillomavirus assay for triage in the referral population and use in primary cervical cancer screening in women 30 years and older: a review of validation studies.

PubMed

Poljak, Mario; Oštrbenk, Anja

2013-01-01

Human papillomavirus (HPV) testing has become an essential part of current clinical practice in the management of cervical cancer and precancerous lesions. We reviewed the most important validation studies of a next-generation real-time polymerase chain reaction-based assay, the RealTime High Risk HPV test (RealTime)(Abbott Molecular, Des Plaines, IL, USA), for triage in referral population settings and for use in primary cervical cancer screening in women 30 years and older published in peer-reviewed journals from 2009 to 2013. RealTime is designed to detect 14 high-risk HPV genotypes with concurrent distinction of HPV-16 and HPV-18 from 12 other HPV genotypes. The test was launched on the European market in January 2009 and is currently used in many laboratories worldwide for routine detection of HPV. We concisely reviewed validation studies of a next-generation real-time polymerase chain reaction (PCR)-based assay: the Abbott RealTime High Risk HPV test. Eight validation studies of RealTime in referral settings showed its consistently high absolute clinical sensitivity for both CIN2+ (range 88.3-100%) and CIN3+ (range 93.0-100%), as well as comparative clinical sensitivity relative to the currently most widely used HPV test: the Qiagen/Digene Hybrid Capture 2 HPV DNA Test (HC2). Due to the significantly different composition of the referral populations, RealTime absolute clinical specificity for CIN2+ and CIN3+ varied greatly across studies, but was comparable relative to HC2. Four validation studies of RealTime performance in cervical cancer screening settings showed its consistently high absolute clinical sensitivity for both CIN2+ and CIN3+, as well as comparative clinical sensitivity and specificity relative to HC2 and GP5+/6+ PCR. RealTime has been extensively evaluated in the last 4 years. RealTime can be considered clinically validated for triage in referral population settings and for use in primary cervical cancer screening in women 30 years and older.

Frequency-Magnitude Relationships for seismic areas around the capital cities of Solomon, Vanuatu, Tonga and Fiji Islands

NASA Astrophysics Data System (ADS)

Hofsetter, A.; Shapira, A.; Bulehite, K.; Jones, T.; Mafia, K.; Malitzky, A.; Papabatu, A.; Prasad, G.; Regnier, M.; Shorten, G.; Singh, A.; Stephen, M.; Vuetibau, L.

We studied the relationships between the frequency ofoccurrence and the magnitudes in seismogenic areasthat will affect four capital cities in the SouthPacific, namely: Honiara in Solomon Islands, Port Vilain Vanuatu, Suva in Fiji and Nuku'alofa in Tonga. Weused the NEIS catalogues for the period 1973-1997, formagnitudes greater than about 5, in the proximity tothe city under investigation. The definitions of thegeographic boundaries of the seismogenic zones arebased on the classical concepts of the distribution ofthe tectonic plates, the overwhelming number ofstudies that describe the seismotectonics in thoseactive regions and on the observed seismicity andstudies of the local people. Completeness of thecatalogue is assumed because of the high seismicity inthese areas, despite the relatively short time span.We have used a hybrid process combining least squaresfitting and Newtonian search process to find the bestfit of the statistical parameters. The characteristicb value is 1.27, and seems to be irrespective of thedepth and/or region.

Deconvoluting the Friction Stir Weld Process for Optimizing Welds

NASA Technical Reports Server (NTRS)

Schneider, Judy; Nunes, Arthur C.

2008-01-01

In the friction stir welding process, the rotating surfaces of the pin and shoulder contact the weld metal and force a rotational flow within the weld metal. Heat, generated by the metal deformation as well as frictional slippage with the contact surface, softens the metal and makes it easier to deform. As in any thermo-mechanical processing of metal, the flow conditions are critical to the quality of the weld. For example, extrusion of metal from under the shoulder of an excessively hot weld may relax local pressure and result in wormhole defects. The trace of the weld joint in the wake of the weld may vary geometrically depending upon the flow streamlines around the tool with some geometry more vulnerable to loss of strength from joint contamination than others. The material flow path around the tool cannot be seen in real time during the weld. By using analytical "tools" based upon the principles of mathematics and physics, a weld model can be created to compute features that can be observed. By comparing the computed observations with actual data, the weld model can be validated or adjusted to get better agreement. Inputs to the model to predict weld structures and properties include: hot working properties ofthe metal, pin tool geometry, travel rate, rotation and plunge force. Since metals record their prior hot working history, the hot working conditions imparted during FSW can be quantified by interpreting the final microstructure. Variations in texture and grain size result from variations in the strain accommodated at a given strain rate and temperature. Microstructural data from a variety of FSWs has been correlated with prior marker studies to contribute to our understanding of the FSW process. Once this stage is reached, the weld modeling process can save significant development costs by reducing costly trial-and-error approaches to obtaining quality welds.

DURIP: Electrokinetic Injection and Separation System for Analysis of Protein and Peptide Transport, Adsorption and Kinetics Instrumentation Proposal

DTIC Science & Technology

2015-03-18

both the electric double layer that forms at a solid-liquid interface as well as the biomolecules themselves, we can harness the coupled physics of...the biomolecules themselves, we can harness the coupled physics of complex biological fluids in nanofluidic channels towards unique, efficient

Short-term exposure to triclosan decreases thyroxine in vivo via upregulation of hepatic catabolism in young long-evans rats

EPA Science Inventory

Triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol)is a chlorinated phenolic antibacterial compound used in consumer products. Structural similarity of triclosan to thyroid hormones, in vitro activation ofthe human pregnane X receptor (PXR) and induction of hepatic Phase I enzymes...

GLOBAL CHANGE RESEARCH NEWS #8: OUR CHANGING PLANET: THE FY2000 U.S. GLOBAL CHANGE RESEARCH PROGRAM

EPA Science Inventory

This edition of Global Change Research News focuses on the publication of the new OurChanging Planet: The FY2000 U.S. Global Change Research Program. This annual report to the Congress was prepared under the auspices ofthe President's National Science and Technology Council. It...

Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis

USDA-ARS?s Scientific Manuscript database

The molecular mechanisms underlying neuronal leptin and insulin resistance in obesity and diabetes remain unclear. Here we show that induction ofthe unfolded protein response transcription factor spliced X-box binding protein 1(Xbp1s) in pro-opio-melanocortin (Pomc) neurons alone is sufficient to pr...

Interferon Antagonism as a Common Virulence Factor of Hemorrhagic Fever Viruses

DTIC Science & Technology

2008-02-01

S. Prehn , A. Leutz, H. Haller, and E. Hartmann. 1997. Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of...the importin-alpha protein family. FEBS Lett 417:104-8. 12. Kohler, M., C. Speck, M. Christiansen, F. R. Bischoff, S. Prehn , H. Haller, D. Gorlich

Transfer Relation between the Compression Test Rig and the Anthropomorphic Test Device (ATD) Lower Leg

DTIC Science & Technology

2015-08-01

2 Fig. 3 FEA model for the ATD lower-leg loading...3 Fig. 4 Typical pressure distribution under the boot sole in the FEA result ................................ 4 Fig. 5 Load histories of...the ATD lower leg in 10-meter-per-second (m/s), 10-millisecond (msec) pulse loading FEA

Methods of Technological Forecasting,

DTIC Science & Technology

1977-05-01

Trend Extrapolation Progress Curve Analogy Trend Correlation Substitution Analysis or Substitution Growth Curves Envelope Curve Advances in the State of...the Art Technological Mapping Contextual Mapping Matrix Input-Output Analysis Mathematical Models Simulation Models Dynamic Modelling. CHAPTER IV...Generation Interaction between Needs and Possibilities Map of the Technological Future — (‘ross- Impact Matri x Discovery Matrix Morphological Analysis

Predicting fire spread in Arizona's oak chaparral

Treesearch

A. W. Lindenmuth; James R. Davis

1973-01-01

Five existing fire models, both experimental and theoretical, did not adequately predict rate-of-spread (ROS) when tested on single- and multiclump fires in oak chaparral in Arizona. A statistical model developed using essentially the same input variables but weighted differently accounted for 81 percent ofthe variation in ROS. A chemical coefficient that accounts for...

The Investment Policy Statement

ERIC Educational Resources Information Center

Griswold, John S.; Jarvis, William F.

2011-01-01

Successful investing for long-term funds requires a strategic plan. This is true despite--indeed, because of--the fact that the future is unknowable. The plan must be specific, embodying in concrete terms the best thinking of the board of trustees about the investment pool, its goals and purposes; but it also needs to be sufficiently flexible to…

Necessity for Consistent and Understandable Engagement Policies with Non-State Actors

DTIC Science & Technology

2008-04-01

the United States. "The United States and Nicaragua. " 84 Noam Chomsky , Failed States. New York, NY: Owl Books, 2007,139. 85 LeoGrande. The Reference...89 Chomsky . Failed States, 36. 90 Bush. The National Security Strategy ofthe United States ofAmerica. Forward 2. 38 MMS Bibliography Chomsky , Noam

Base-treated juniper fiber media for removing heavy metals in stormwater runoff

Treesearch

S.-H. Min; Thomas Eberhardt; Jang Min

2007-01-01

The viability of base-treated juniper fiber (BTJF) media for removing toxic heavy metals (Cd2+, Cu2+, Pb2+, Zn2+) in stormwater runoff was investigated. The sorption ability ofthe BTJF for all metals was much higher than that of untreated juniper. The affinity sequence of both...

Disruption of STAT5b-Regulated Sexual Dimorphism of the Liver Transcriptome by Diverse Factors Is a Common Event

EPA Science Inventory

Signal transducer and activator of transcription 5b (STAT5b) is a growth hormone (GH)-activated transcription factor and a master regulator of sexually dimorphic gene expression in the liver. Disruption ofthe GH hypothalamo-pituitary-liver axis controlling STAT5b activation can ...

Shakespeare for the 1990s: A Multicultural Tempest.

ERIC Educational Resources Information Center

Carey-Webb, Allen

1993-01-01

Argues that William Shakespeare's "The Tempest" is the play that is best suited for the high school English curriculum of the 1990s. Discusses historical and critical aspects the play's key themes. Shows ways of using the play in high school classes, and describes 19 works to read alongside of"The Tempest." (HB)

Global, spatial, and temporal sensitivity analysis for a complex pesticide fate and transport model.

EPA Science Inventory

Background/Questions/Methods As one ofthe most heavily used exposure models by U.S. EPA, Pesticide Root Zone Model (PRZM) is a one-dimensional, dynamic, compartment model that predicts the fate and transport of a pesticide in the unsaturated soil system around a plant's root zo...

Sub-Saharan Africa Report

DTIC Science & Technology

1987-02-19

the embryo of the future movement of Jonas Savlmbi." [Question] How is it possible to be sure of this? Would it not have been a matter of...the needs of its people. For me, this country’s prime asset is man. He must forge his own destiny and participate in the task of nation-building

Therapy and treatment with a high-energy laser in case of a periodontal disease treatment instead of physiotherapy or low-level laser treatment

NASA Astrophysics Data System (ADS)

Buerger, Friedhelm R.

1996-12-01

Since intensive efforts ofprophylaxis including fluoridisation, better oral hygiene, eating ofless sugar containing foods, reduced the risk ofcaries and the problems ofcaries lesions significantly. But, especially beginning at the age of3O years more than 80 % ofthe population in almost every nation shows signs of periodontal defects. This you can call an epidemic disease. Because people get older and expect a lot concerning their outlook, their esthetic, their phonetic, they have great expectations towards their natural dentition and keep their own teeth. This is a great challenge to periodontal prophylaxis and periodontal therapy. According to the progress ofthe disease different therapies are indicated. Starting with oral hygiene instructions to establish better oral hygiene with all the modem technologies ofmicrobiological investigations, pharmaceutical therapy, physiotherapy, low level laser treatment, periodontal-surgery, like curettage, deepscaling and rootplaning but also more sophisticated teatmentplans with gingivoplasty, gingivectomy, flap-procedures and mucogingival surgeiy including bone fillings, regenerativ technics the whole spectrum oftreatment options has widely expanded during the last years.

Earthquake Complex Network Analysis Before and After the Mw 8.2 Earthquake in Iquique, Chile

NASA Astrophysics Data System (ADS)

Pasten, D.

2017-12-01

The earthquake complex networks have shown that they are abble to find specific features in seismic data set. In space, this networkshave shown a scale-free behavior for the probability distribution of connectivity, in directed networks and theyhave shown a small-world behavior, for the undirected networks.In this work, we present an earthquake complex network analysis for the large earthquake Mw 8.2 in the north ofChile (near to Iquique) in April, 2014. An earthquake complex network is made dividing the three dimensional space intocubic cells, if one of this cells contain an hypocenter, we name this cell like a node. The connections between nodes aregenerated in time. We follow the time sequence of seismic events and we are making the connections betweennodes. Now, we have two different networks: a directed and an undirected network. Thedirected network takes in consideration the time-direction of the connections, that is very important for the connectivityof the network: we are considering the connectivity, ki of the i-th node, like the number of connections going out ofthe node i plus the self-connections (if two seismic events occurred successive in time in the same cubic cell, we havea self-connection). The undirected network is made removing the direction of the connections and the self-connectionsfrom the directed network. For undirected networks, we are considering only if two nodes are or not connected.We have built a directed complex network and an undirected complex network, before and after the large earthquake in Iquique. We have used magnitudes greater than Mw = 1.0 and Mw = 3.0. We found that this method can recognize the influence of thissmall seismic events in the behavior of the network and we found that the size of the cell used to build the network isanother important factor to recognize the influence of the large earthquake in this complex system. This method alsoshows a difference in the values of the critical exponent γ (for the probability distribution of connectivity in the directednetwork) before and after the large earthquake, but this method does not show a change in the clustering behavior ofthe undirected network, before and after the large earthquake, showing a small-world behavior for the network beforeand after of this large seismic event.

StarBase: A Firm Real-Time Database Manager for Time-Critical Applications

DTIC Science & Technology

1995-01-01

Mellon University [IO]. StarBase differs from previous RT-DBMS work [l, 2, 31 in that a) it relies on a real - time operating system which provides...simulation studies, StarBase uses a real - time operating system to provide basic real-time functionality and deals with issues beyond transaction...re- source scheduling provided by the underlying real - time operating system . Issues of data contention are dealt with by use of a priority

Real-time Simulation of Turboprop Engine Control System

NASA Astrophysics Data System (ADS)

Sheng, Hanlin; Zhang, Tianhong; Zhang, Yi

2017-05-01

On account of the complexity of turboprop engine control system, real-time simulation is the technology, under the prerequisite of maintaining real-time, to effectively reduce development cost, shorten development cycle and avert testing risks. The paper takes RT-LAB as a platform and studies the real-time digital simulation of turboprop engine control system. The architecture, work principles and external interfaces of RT-LAB real-time simulation platform are introduced firstly. Then based on a turboprop engine model, the control laws of propeller control loop and fuel control loop are studied. From that and on the basis of Matlab/Simulink, an integrated controller is designed which can realize the entire process control of the engine from start-up to maximum power till stop. At the end, on the basis of RT-LAB platform, the real-time digital simulation of the designed control system is studied, different regulating plans are tried and more ideal control effects have been obtained.

Real-time polymerase chain reaction assay for rapid and sensitive detection of anthrax spores in spiked soil and talcum powder.

PubMed

Jain, Neha; Merwyn, S; Rai, G P; Agarwal, G S

2012-05-01

Real-time polymerase chain reaction (real-time PCR) is a laboratory technique based on PCR. This technique is able to detect sequence-specific PCR products as they accumulate in "real time" during the PCR amplification, and also to quantify the number of substrates present in the initial PCR mixture before amplification begins. In the present study, real-time PCR assay was employed for rapid and real-time detection of Bacillus anthracis spores spiked in 0.1 g of soil and talcum powder ranging from 5 to 10(7) spores. DNA was isolated from spiked soil and talcum powder, using PBS containing 1 % Triton-X-100, followed by heat treatment. The isolated DNA was used as template for real-time PCR and PCR. Real-time PCR amplification was obtained in 60 min under the annealing condition at 60°C by employing primers targeting the pag gene of B. anthracis. In the present study, the detection limit of real-time PCR assay in soil was 10(3) spores and 10(2) spores in talcum powder, respectively, whereas PCR could detect 10(4) spores in soil and 10(3) spores in talcum powder, respectively.

BIOCHEMICAL INDICATORS OF HEPATOTOXICITY IN BLOOD SERUM OF RATS UNDER THE EFFECT OF NOVEL 4-THIAZOLIDINONE DERIVATIVES AND DOXORUBICIN AND THEIR COMPLEXES WITH POLYETHYLENEGLYCOL-CONTAINING NANOSCALE POLYMERIC CARRIER.

PubMed

Kobylinska, L I; Havrylyuk, D Ya; Ryabtseva, A O; Mitina, N E; Zaichenko, O S; Lesyk, R B; Zimenkovsky, B S; Stoika, R S

2015-01-01

The aim of this study was to compare the effect of new synthetic 4-tiazolidinone derivatives (compounds 3882, 3288 and 3833) and doxorubicin (positive control) in free form and in their complexes with synthetic polyethyleneglycol-containing nanoscale polymeric carrier on the biochemical indicators of hepatotoxicity in blood serum of rats. The activity of enzymes considered as the markers of hepatotoxicity, as well as. the concentration of total protein, urea and creatinine were measured in blood serum of rats. It was found that after injection of investigated compounds the activities ofalanine aminotransferase, alkaline phosphatase and α-amylase increased in comparison to control. Doxorubicin injection was accompanied by 4-fold increase in the activity of γ-glutamyltransferase, and injection ofcompound 3833 led to 2.5-fold elevation ofthe activity of this enzyme. Complexation ofthese antineoplastic derivatives with a synthetic nanocarrier lowered the activity ofthe investigated enzymes substantially if compared to the effect of these compounds infreeform. The most evident decrease was measured for α-amylase, γ-glutamyltransferase and lactate dehydrogenase activities. The normalization of concentrations of total protein, urea and creatinine in blood serum of rats treated with complexes of the studied compounds with a polymeric carrier comparing with their introduction infreeform was also detected. Thus, the immobilization by novel polymeric carrier of anticancer drugs possessing high general toxicity in the treated organism mitigates their toxic effect, which is evident as normalization of specific biochemical indicators of the hepatodestructive effects of the anticancer drugs.

[THE FEATURES OF PREVALENCE OF SKIN DISEASE AS AN INDEX OF ECOLOGICALLY RELATED MORBIDITY OF POPULATION IN BIOCLIMATIC ZONES OF PRIMORYE KRAI].

PubMed

Yarygina, M V; Kiku, P F; Gorborukova, T V

2015-01-01

There are presented results of the socio-hygienic analysis of ecologically related skin pathology ofthe population of Primorsky Krai. The aim of the work is to establish the patterns of distribution of ecologically related skin diseases in various ecological bioclimatic zones of Primorsky Krai. There was performed an analysis of skin diseases ofform 12 according to ICD-10 main demographic groups (children, adolescents and adults) of the population of Primorsky Krai, residing in various bioclimatic zones of Krai with different levels of environmental stringency in rural and urban areas for the period of 2000-2013. There were established causal-effect relationships of the prevalence of skin diseases, as ecologically related pathology. The level of the prevalence of skin diseases among the population in the Primorye region depends on bioclimatic zones, the degree of the stringency of the environmental situation and combinations of environmental factors. The prevalence of skin diseases in adults, adolescents and children, as the organism's response to the impact ofthe parameters ofthe environment is affected by the complex offactors, the main of them are hygienic: the sanitary--hygienic level of ambient air pollution, the specification of chemical pollution and adverse physical factors in urban and rural settlements, the characteristics of the state of the soil. The medical-sociological research of the lifestyle of the population was performed on the basis of a specially designed questionnaire. The questionnaire included three arrays of issues: environmental, hygienic and social. On the basis of medical and sociological research with the use of multivariate analysis, method of correlation pleiades advanced by P. V. Terentiev, lifestyle and psycho-emotional factors, socio-hygienic, bioclimatic factors were found to play an important role in the prevalence of ecologically related pathology of skin in residents of Primorsky Krai. Differences in responses between urban and rural residents living in areas with various environmental stringency, confirm the preposition about the ambiguity of the approach to the solution of social, hygienic and environmental problems in areas with different socio-economic situation. The obtained results of the study allow us to determine the main directions of treatment and prevention and to develop targeted prevention programs.

Using cell membrane chromatography and HPLC-TOF/MS method for in vivo study of active components from roots of Aconitum carmichaeli

PubMed Central

Cao, Yan; Chen, Xiao-Fei; Lü, Di-Ya; Dong, Xin; Zhang, Guo-Qing; Chai, Yi-Feng

2012-01-01

An offline two-dimensional system combining a rat cardiac muscle cell membrane chromatography time-of-flight mass spectrometry (CMC-TOF/MS) with a high Performance liquid chromatography time-of-flight mass spectrometry (HPLC-TOF/MS) was established for investigating the parent components and metabolites in rat urine samples after administration of the roots of Aconitum carmichaeli. On the basis ofthe analysis of the first dimension, retention components of the urine sample were collected into 30 fractions (one fraction per minute). Then offline analysis of the second dimension was carried out. 34 compounds including 24 parent alkaloids and 10 potential metabolites were identified from the dosed rat urine, and then binding affinities of different compounds on cell membranes were compared and influences of some functional groups on activity were estimated with the semi-quantification and curve fitting method. As a result, binding affinities decreased along with the process of deacylation, debenzoylation and demethylation, which may be related to the alleviation of toxicity in the procedure of herb processing or metabolism. Moreover, some minor components in rat urine (Songorine, 14-benzoylneoline, Deoxyaconitine, etc.) exerted relatively strong affinity on cell membranes are worth exploring. The results delivered by the System suggest that the CMC can be applied to in vivo study. PMID:29403691

Flowfield And Download Measurements And Computation of a Tiltrotor Aircraft In Hover

NASA Technical Reports Server (NTRS)

Brand, Albert G.; Peryea, Martin A.; Wood, Tom L.; Meakin, Robert L.

2001-01-01

A multipart study of the V-22 hover flowfield was conducted. Testing involved a 0.15-scale semispan model with multiple independent force balance systems. The velocity flowfield surrounding the airframe was measured using a robotic positioning system and anemometer. Both time averaged and cycle-averaged results are reported. It is shown that the fuselage download in hover can be significantly reduced using a small download reduction device. Measurements indicate that the success of the device is attributed to the substantial elimination of tiltrotor fountain flow. As part of.the study, an unsteady CFD prediction is time-averaged, and shown to have excellent agreement in predicting the baseline configuration fountain flow. Some discrepancies at the outboard edge of the rotor are discussed. An &&sessment of an advanced tip shape rotor comp"'Ietes the study. Derived from a nonrotating study, the advanced tip shape rotor was developed and tested on the Bell 0.15 scale semi-span V-22 model. The tip shape was intended to diffuse the tip vortex and reduce BVI noise. Rotor wake vorticity is extracted from the measured velocity dam to show that the advanced tip shape produces a tip vortex that is only slightly more diffuse than the baseline tip blade. The results indicate that nonrotating tests may overpredict the amount of tip vortex diffusion achieved by tip shape design in a rotating environment.

Estimating Real-Time Zenith Tropospheric Delay over Africa Using IGS-RTS Products

NASA Astrophysics Data System (ADS)

Abdelazeem, M.

2017-12-01

Zenith Tropospheric Delay (ZTD) is a crucial parameter for atmospheric modeling, severe weather monitoring and forecasting applications. Currently, the international global navigation satellite system (GNSS) real-time service (IGS-RTS) products are used extensively in real-time atmospheric modeling applications. The objective of this study is to develop a real time zenith tropospheric delay estimation model over Africa using the IGS-RTS products. The real-time ZTDs are estimated based on the real-time precise point positioning (PPP) solution. GNSS observations from a number of reference stations are processed over a period of 7 days. Then, the estimated real-time ZTDs are compared with the IGS tropospheric products counterparts. The findings indicate that the estimated real-time ZTDs have millimeter level accuracy in comparison with the IGS counterparts.

Research in Distributed Real-Time Systems

NASA Technical Reports Server (NTRS)

Mukkamala, R.

1997-01-01

This document summarizes the progress we have made on our study of issues concerning the schedulability of real-time systems. Our study has produced several results in the scalability issues of distributed real-time systems. In particular, we have used our techniques to resolve schedulability issues in distributed systems with end-to-end requirements. During the next year (1997-98), we propose to extend the current work to address the modeling and workload characterization issues in distributed real-time systems. In particular, we propose to investigate the effect of different workload models and component models on the design and the subsequent performance of distributed real-time systems.

Real-time GIS data model and sensor web service platform for environmental data management.

PubMed

Gong, Jianya; Geng, Jing; Chen, Zeqiang

2015-01-09

Effective environmental data management is meaningful for human health. In the past, environmental data management involved developing a specific environmental data management system, but this method often lacks real-time data retrieving and sharing/interoperating capability. With the development of information technology, a Geospatial Service Web method is proposed that can be employed for environmental data management. The purpose of this study is to determine a method to realize environmental data management under the Geospatial Service Web framework. A real-time GIS (Geographic Information System) data model and a Sensor Web service platform to realize environmental data management under the Geospatial Service Web framework are proposed in this study. The real-time GIS data model manages real-time data. The Sensor Web service platform is applied to support the realization of the real-time GIS data model based on the Sensor Web technologies. To support the realization of the proposed real-time GIS data model, a Sensor Web service platform is implemented. Real-time environmental data, such as meteorological data, air quality data, soil moisture data, soil temperature data, and landslide data, are managed in the Sensor Web service platform. In addition, two use cases of real-time air quality monitoring and real-time soil moisture monitoring based on the real-time GIS data model in the Sensor Web service platform are realized and demonstrated. The total time efficiency of the two experiments is 3.7 s and 9.2 s. The experimental results show that the method integrating real-time GIS data model and Sensor Web Service Platform is an effective way to manage environmental data under the Geospatial Service Web framework.

VESTA Project: Phase 0 report

NASA Technical Reports Server (NTRS)

Perret, A.

1986-01-01

This report presents the results of technical studies conducted at CNES/PMF/APS between October 1984 and September 1985 on the VESTA project. These preliminary studies were conducted to establish mission feasibility in terms ofthe trajectory and the scientific objectives, and to determine the type of interfaces which will be required with the Soviets and to measure the magnitude of French participation. A joint French-Soviet report recommends that the project enter phase A, and was approved by CNES and INTERCOSMOS in September, 1985. The mission analysis is made for a mid-1991 launch, and a development schedule for an end-1992 launch is suggested. The decision to postpone the mission was made during the course of the study.

Capturing patient experience: a qualitative study of implementing real-time feedback in primary care

PubMed Central

Carter, Mary; Davey, Antoinette; Wright, Christine; Elmore, Natasha; Newbould, Jenny; Roland, Martin; Campbell, John; Burt, Jenni

2016-01-01

Background In recent years, hospitals have made use of new technologies, such as real-time feedback, to collect patient experience information. This approach is currently rarely used in primary care settings, but may provide practices with a useful tool that enables them to take prompt, focused action to improve their services. Aim To identify the factors inhibiting and enabling the implementation of real-time feedback in general practices. Design and setting Qualitative study embedded within an exploratory trial (July 2014 to February 2015) of a real-time feedback intervention targeting patient experience in general practices in south-west England and Cambridgeshire. Method Semi-structured interviews (n = 22) and focus groups (n = 4, total of 28 attendees) with practice staff were audiorecorded, transcribed, and analysed thematically, using a framework based on constructs from normalisation process theory. Results Staff engagement with real-time feedback varied considerably, and staff made sense of real-time feedback by comparing it with more familiar feedback modalities. Effective within-team communication was associated with positive attitudes towards real-time feedback. Timing of requests for feedback was important in relation to patient engagement. Real-time feedback may offer potential as a means of informing practice development, perhaps as a component of a wider programme of capturing and responding to patients’ comments. Conclusion Successful implementation of real-time feedback requires effective communication across the practice team to engender thorough engagement. Feedback processes should be carefully introduced to fit with existing patient and practice routines. Future studies should consider making real-time feedback content relevant to specific practice needs, and support participation by all patient groups. PMID:27621292

Clinical usefulness of augmented reality using infrared camera based real-time feedback on gait function in cerebral palsy: a case study.

PubMed

Lee, Byoung-Hee

2016-04-01

[Purpose] This study investigated the effects of real-time feedback using infrared camera recognition technology-based augmented reality in gait training for children with cerebral palsy. [Subjects] Two subjects with cerebral palsy were recruited. [Methods] In this study, augmented reality based real-time feedback training was conducted for the subjects in two 30-minute sessions per week for four weeks. Spatiotemporal gait parameters were used to measure the effect of augmented reality-based real-time feedback training. [Results] Velocity, cadence, bilateral step and stride length, and functional ambulation improved after the intervention in both cases. [Conclusion] Although additional follow-up studies of the augmented reality based real-time feedback training are required, the results of this study demonstrate that it improved the gait ability of two children with cerebral palsy. These findings suggest a variety of applications of conservative therapeutic methods which require future clinical trials.

Advanced Diagnostics for Reacting Flows

DTIC Science & Technology

2006-06-01

TECHNICAL DISCUSSION: 1. Infrared-PLIF Imaging Diagnostics using Vibrational Transitions IR-PLIF allows for imaging a group of molecular species important...excitation of IR-active vibrational modes with imaging of the subsequent vibrational fluorescence. Quantitative interpretation requires knowledge of...the vibrational energy transfer processes, and hence in recent years we have been developing models for infrared fluorescence. During the past year

Force and Accommodation in World Politics

DTIC Science & Technology

1991-08-01

interest of academic freedom and the advancement of national defense-related concepts . The views expressed in this publication are those ofthe author...political, economic , social, and environmental-havecombined in this nuclear age to make many of the past practices of the superpowers irrelevant...American rapprochement . Preface With economic pressures, demographic changes, and the acknowledged futility of nuclear war steadily eroding the

Overproduction of Hydrogen From an Anaerobic Bacterium

DTIC Science & Technology

2008-12-01

fixation of nitrogen ( Haber - Bosch process), mostly to produce fertilizer. Nitrogenase provides a catalytic alternative to the commercial fixation of...the culture and suggests a uniquely simple hydrogen reactor design based on renewable feedstocks. 1. INTRODUCTION Hydrogen is an ideal... renewable feedstocks. Clostridium phytofermentans is a recently- discovered anaerobic bacterium, reported to possess cellulase enzymes that degrade

USSR and Eastern Europe Scienitfic Abstracts, Geophysics, Astronomy and Space, Number 402

DTIC Science & Technology

1977-07-27

for the stations Arosa , Ox- ford and Hradec Kralove, whereas a negative (dropping) trend was found for the stations Belsk and Potsdam. The highest of...the three positive values is that of Oxford, being +2.15% for the 10-year period. The positive values of the stations Arosa and Hradec Kralove are

Operation Dragoon: The Race Up the Rhone

DTIC Science & Technology

2016-05-26

should be familiar with the exploits of the US Seventh Anny and its French allies. 1S. SUBJECT TERMS Operation Dragoon, European Theater of...the Rhone Valley, and its overall effects on the European Theater of Operations, useful lessons are drawn for both contemporary commanders and planners...57 Southern France’s Effects on the European Theater of Operations

A Decision Analysis Tool for the Source Selection Process

DTIC Science & Technology

2006-03-01

THE SOURCE SELECTION PROCESS THESIS Presented to the Faculty Department of Systems and Engineering Management Graduate School of...Engineering and Management Air Force Institute of Technology Air University Air Education and Training Command In Partial Fulfillment of...the Requirements for the Degree of Master of Science in Engineering Management John R. Trumm, BS Captain, USAF March 2006

Coppicing to convert small cull trees to growing stock

Treesearch

Gerald A. Walters

1972-01-01

Several tree species are now being planted in Hawaii to reforest areas on which firetree (Myrica faya Ait.)-a plant pest of little commercial value-has been killed. The potential of converting cull trees of five ofthe replacement species into growing stock trees by coppicing was evaluated. Australian toon and tropical ash showed the greatest...

THE COMPUTATION OF CHARACTERISTIC EXPONENTS IN THE PLANAR RESTRICTED PROBLEM OF THREE BODIES

DTIC Science & Technology

methods are applied to evaluate the characteristic exponents of Rabe’s Trojan Orbits; they are found to be of the stable type for the ovals, and of...the unstable type for the horse -shoe shaped orbit. When the periodic orbit is symmetric with respect to the axis of syzygies, four independent

USSR Report, Political and Sociological Affairs, No. 1444.

DTIC Science & Technology

1983-08-12

are needed. Only 65 percent of the farms are supplied with lined capacities for the storage of silage and haylage , as a result up to 20 percent of...the nutrients in the fodders are being lost. In the next few months before the start of the mass laying in of silage and haylage the kolkhozes and

Detection of tumor markers in prostate cancer and comparison of sensitivity between real time and nested PCR.

PubMed

Matsuoka, Takayuki; Shigemura, Katsumi; Yamamichi, Fukashi; Fujisawa, Masato; Kawabata, Masato; Shirakawa, Toshiro

2012-06-27

The objective of this study is to investigate and compare the sensitivity in conventional PCR, quantitative real time PCR, nested PCR and western blots for detection of prostate cancer tumor markers using prostate cancer (PCa) cells. We performed conventional PCR, quantitative real time PCR, nested PCR, and western blots using 5 kinds of PCa cells. Prostate specific antigen (PSA), prostate specific membrane antigen (PSMA), and androgen receptor (AR) were compared for their detection sensitivity by real time PCR and nested PCR. In real time PCR, there was a significant correlation between cell number and the RNA concentration obtained (R(2)=0.9944) for PSA, PSMA, and AR. We found it possible to detect these markers from a single LNCaP cell in both real time and nested PCR. By comparison, nested PCR reached a linear curve in fewer PCR cycles than real time PCR, suggesting that nested PCR may offer PCR results more quickly than real time PCR. In conclusion, nested PCR may offer tumor maker detection in PCa cells more quickly (with fewer PCR cycles) with the same high sensitivity as real time PCR. Further study is necessary to establish and evaluate the best tool for PCa tumor marker detection.

Clinical evaluation of β-tubulin real-time PCR for rapid diagnosis of dermatophytosis, a comparison with mycological methods.

PubMed

Motamedi, Marjan; Mirhendi, Hossein; Zomorodian, Kamiar; Khodadadi, Hossein; Kharazi, Mahboobeh; Ghasemi, Zeinab; Shidfar, Mohammad Reza; Makimura, Koichi

2017-10-01

Following our previous report on evaluation of the beta tubulin real-time PCR for detection of dermatophytosis, this study aimed to compare the real-time PCR assay with conventional methods for the clinical assessment of its diagnostic performance. Samples from a total of 853 patients with suspected dermatophyte lesions were subjected to direct examination (all samples), culture (499 samples) and real-time PCR (all samples). Fungal DNA was extracted directly from clinical samples using a conical steel bullet, followed by purification with a commercial kit and subjected to the Taq-Man probe-based real-time PCR. The study showed that among the 499 specimens for which all three methods were used, 156 (31.2%), 128 (25.6%) and 205 (41.0%) were found to be positive by direct microscopy, culture and real-time PCR respectively. Real-time PCR significantly increased the detection rate of dermatophytes compared with microscopy (288 vs 229) with 87% concordance between the two methods. The sensitivity, specificity, positive predictive value, and negative predictive value of the real-time PCR was 87.5%, 85%, 66.5% and 95.2% respectively. Although real-time PCR performed better on skin than on nail samples, it should not yet fully replace conventional diagnosis. © 2017 Blackwell Verlag GmbH.

A Comparison of Priority-based and Incremental Real-Time Garbage Collectors in the Implementation of the Shadow Design Pattern

DTIC Science & Technology

2008-08-15

running the real-time application we used in our previous study on IBM WebSphere Real Time. IBM WebSphere Real Time automatically sets Metronome , its...the experiment show that the modified code for the Shadow Design Pattern runs well under Metronome . 15. NUMBER OF PAGES 25 14. SUBJECT TERMS...includes the real-time garbage collector called the Metronome . Unlike the Sun RTGC, we cannot change the priority of the Metronome RTGC. Metronome is

On the Interannual Variability and on Trends of the Temperature in the Middle Atmosphere

NASA Technical Reports Server (NTRS)

Labitzke, K.; Naujokat, B.

1985-01-01

The new Reference Atmosphere presented here is based on global satellite data and forms a very useful basis for climatological studies. When using such climatologies it is important to be aware of the well known interannual variability which n themiddle atmosphere is particularly large during the northern winters and southern springs. Variability ofthe upper and lower stratospheres is discussed in detail. Areas covered included the polar region and the middile and lower latitudes. Temperature trends, notably the alteration of the global temperature structure by a number of anthropogenically influenced tract gases or the greenhouse effect is discussed.

Pathological grief and the activation of latent self-images.

PubMed

Horowitz, M J; Wilner, N; Marmar, C; Krupnick, J

1980-10-01

The authors studied the case material for patients treated with either psychoanalysis or brief therapy to examine the basis for the various states of pathological grief after berevavement. They view these states as intensifications or unusual prolongations of states found in normal grief and describe them in terms of the reemergence of self-images and role relationship models that had been held in check by the existence ofthe deceased person. This conclusion concerning preexisting mental schemata leads to an elaboration and partial revision of theories of regression, ambivalence, and introjection as causes of pathological grief.

Proceedings of the Fourth International Symposium on the Interaction of Non-Nuclear Munitions with Structures Held in Panama City Beach, Florida on 17- 21 April 1989. Volume 1

DTIC Science & Technology

1989-04-21

Christiansen , B.K., Twenty-Five Years of vulnerability analysis, weapon design, weapon Penetration Records at Sandia National effectiveness studies, and...of Leighton Buzzard sand is explosive mass of 432 Kg, and one at 1 g. 2.65 and the maximum and minimum void ratios for Active measurements were made of...the tub as far as possible. Gaps 1.0 INTRODUCTION between the blocks and the walls were filled with coarse Leighton Buzzard 14/25 sand (nominal Small

OPTIMIZED REAL-TIME CONTROL OF COMBINED SEWERAGE SYSTEMS: TWO CASE STUDIES

EPA Science Inventory

The paper presents results of two case studies of Real-Time Control (RTC) alternatives evaluations that were conducted on portions of sewerage systems near Paris, France and in Quebec City, Canada, respectively. The studies were performed at real-scale demonstration sites. RTC ...

Applying MDA to SDR for Space to Model Real-time Issues

NASA Technical Reports Server (NTRS)

Blaser, Tammy M.

2007-01-01

NASA space communications systems have the challenge of designing SDRs with highly-constrained Size, Weight and Power (SWaP) resources. A study is being conducted to assess the effectiveness of applying the MDA Platform-Independent Model (PIM) and one or more Platform-Specific Models (PSM) specifically to address NASA space domain real-time issues. This paper will summarize our experiences with applying MDA to SDR for Space to model real-time issues. Real-time issues to be examined, measured, and analyzed are: meeting waveform timing requirements and efficiently applying Real-time Operating System (RTOS) scheduling algorithms, applying safety control measures, and SWaP verification. Real-time waveform algorithms benchmarked with the worst case environment conditions under the heaviest workload will drive the SDR for Space real-time PSM design.

A study of internet of things real-time data updating based on WebSocket

NASA Astrophysics Data System (ADS)

Wei, Shoulin; Yu, Konglin; Dai, Wei; Liang, Bo; Zhang, Xiaoli

2015-12-01

The Internet of Things (IoT) is gradually entering the industrial stage. Web applications in IoT such as monitoring, instant messaging, real-time quote system changes need to be transmitted in real-time mode to client without client constantly refreshing and sending the request. These applications often need to be as fast as possible and provide nearly real-time components. Real-time data updating is becoming the core part of application layer visualization technology in IoT. With support of data push in server-side, running state of "Things" in IoT could be displayed in real-time mode. This paper discusses several current real-time data updating method and explores the advantages and disadvantages of each method. We explore the use of WebSocket in a new approach for real-time data updating in IoT, since WebSocket provides low delay, low network throughput solutions for full-duplex communication.

Real-Time MRI-Guided Cardiac Cryo-Ablation: A Feasibility Study.

PubMed

Kholmovski, Eugene G; Coulombe, Nicolas; Silvernagel, Joshua; Angel, Nathan; Parker, Dennis; Macleod, Rob; Marrouche, Nassir; Ranjan, Ravi

2016-05-01

MRI-based ablation provides an attractive capability of seeing ablation-related tissue changes in real time. Here we describe a real-time MRI-based cardiac cryo-ablation system. Studies were performed in canine model (n = 4) using MR-compatible cryo-ablation devices built for animal use: focal cryo-catheter with 8 mm tip and 28 mm diameter cryo-balloon. The main steps of MRI-guided cardiac cryo-ablation procedure (real-time navigation, confirmation of tip-tissue contact, confirmation of vessel occlusion, real-time monitoring of a freeze zone formation, and intra-procedural assessment of lesions) were validated in a 3 Tesla clinical MRI scanner. The MRI compatible cryo-devices were advanced to the right atrium (RA) and right ventricle (RV) and their position was confirmed by real-time MRI. Specifically, contact between catheter tip and myocardium and occlusion of superior vena cava (SVC) by the balloon was visually validated. Focal cryo-lesions were created in the RV septum. Circumferential ablation of SVC-RA junction with no gaps was achieved using the cryo-balloon. Real-time visualization of freeze zone formation was achieved in all studies when lesions were successfully created. The ablations and presence of collateral damage were confirmed by T1-weighted and late gadolinium enhancement MRI and gross pathological examination. This study confirms the feasibility of a MRI-based cryo-ablation system in performing cardiac ablation procedures. The system allows real-time catheter navigation, confirmation of catheter tip-tissue contact, validation of vessel occlusion by cryo-balloon, real-time monitoring of a freeze zone formation, and intra-procedural assessment of ablations including collateral damage. © 2016 Wiley Periodicals, Inc.

A COMPARATIVE STUDY OF REAL-TIME AND STATIC ULTRASONOGRAPHY DIAGNOSES FOR THE INCIDENTAL DETECTION OF DIFFUSE THYROID DISEASE.

PubMed

Kim, Dong Wook

2015-08-01

The aim of this study was to compare the diagnostic accuracy of real-time and static ultrasonography (US) for the incidental detection of diffuse thyroid disease (DTD). In 118 consecutive patients, a single radiologist performed real-time US before thyroidectomy. For static US, the same radiologist retrospectively investigated the sonographic findings on a picture-archiving and communication system after 3 months. The diagnostic categories of both real-time and static US diagnoses were determined based on the number of abnormal findings, and the diagnostic indices were calculated by a receiver operating characteristic (ROC) curve analysis using the histopathologic results as the reference standard. Histopathologic results included normal thyroid (n = 77), Hashimoto thyroiditis (n = 11), non-Hashimoto lymphocytic thyroiditis (n = 29), and diffuse hyperplasia (n = 1). Normal thyroid and DTD showed significant differences in echogenicity, echotexture, glandular margin, and vascularity on both real-time and static US. There was a positive correlation between US categories and histopathologic results in both real-time and static US. The highest diagnostic indices were obtained when the cutoff criteria of real-time and static US diagnoses were chosen as indeterminate and suspicious for DTD, respectively. The ROC curve analysis showed that real-time US was superior to static US in diagnostic accuracy. Both real-time and static US may be helpful for the detection of incidental DTD, but real-time US is superior to static US for detecting incidental DTD.

Comparison of nested-multiplex, Taqman & SYBR Green real-time PCR in diagnosis of amoebic liver abscess in a tertiary health care institute in India.

PubMed

Dinoop, K P; Parija, Subhash Chandra; Mandal, Jharna; Swaminathan, R P; Narayanan, P

2016-01-01

Amoebiasis is a common parasitic infection caused by Entamoeba histolytica and amoebic liver abscess (ALA) is the most common extraintestinal manifestation of amoebiasis. The aim of this study was to standardise real-time PCR assays (Taqman and SYBR Green) to detect E. histolytica from liver abscess pus and stool samples and compare its results with nested-multiplex PCR. Liver abscess pus specimens were subjected to DNA extraction. The extracted DNA samples were subjected to amplification by nested-multiplex PCR, Taqman (18S rRNA) and SYBR Green real-time PCR (16S-like rRNA assays to detect E. histolytica/E. dispar/E. moshkovskii). The amplification products were further confirmed by DNA sequence analysis. Receiver operator characteristic (ROC) curve analysis was done for nested-multiplex and SYBR Green real-time PCR and the area under the curve was calculated for evaluating the accuracy of the tests to dignose ALA. In all, 17, 19 and 25 liver abscess samples were positive for E. histolytica by nested-multiplex PCR, SYBR Green and Taqman real-time PCR assays, respectively. Significant differences in detection of E. histolytica were noted in the real-time PCR assays evaluated ( P<0.0001). The nested-multiplex PCR, SYBR Green real-time PCR and Taqman real-time PCR evaluated showed a positivity rate of 34, 38 and 50 per cent, respectively. Based on ROC curve analysis (considering Taqman real-time PCR as the gold standard), it was observed that SYBR Green real-time PCR was better than conventional nested-multiplex PCR for the diagnosis of ALA. Taqman real-time PCR targeting the 18S rRNA had the highest positivity rate evaluated in this study. Both nested multiplex and SYBR Green real-time PCR assays utilized were evaluated to give accurate results. Real-time PCR assays can be used as the gold standard in rapid and reliable diagnosis, and appropriate management of amoebiasis, replacing the conventional molecular methods.

Real-time three-dimensional color doppler evaluation of the flow convergence zone for quantification of mitral regurgitation: Validation experimental animal study and initial clinical experience

NASA Technical Reports Server (NTRS)

Sitges, Marta; Jones, Michael; Shiota, Takahiro; Qin, Jian Xin; Tsujino, Hiroyuki; Bauer, Fabrice; Kim, Yong Jin; Agler, Deborah A.; Cardon, Lisa A.; Zetts, Arthur D.;

Comparison of Hybrid Capture 2 Assay with Real-time-PCR for Detection and Quantitation of Hepatitis B Virus DNA.

PubMed

Majid, Farjana; Jahan, Munira; Lutful Moben, Ahmed; Tabassum, Shahina

2014-01-01

Both real-time-polymerase chain reaction (PCR) and hybrid capture 2 (HC2) assay can detect and quantify hepatitis B virus (HBV) DNA. However, real-time-PCR can detect a wide range of HBV DNA, while HC2 assay could not detect lower levels of viremia. The present study was designed to detect and quantify HBV DNA by real-time-PCR and HC2 assay and compare the quantitative data of these two assays. A cross-sectional study was conducted in between July 2010 and June 2011. A total of 66 serologically diagnosed chronic hepatitis B (CHB) patients were selected for the study. Real-time-PCR and HC2 assay was done to detect HBV DNA. Data were analyzed by statistical Package for the social sciences (SPSS). Among 66 serologically diagnosed chronic hepatitis B patients 40 (60.61%) patients had detectable and 26 (39.39%) had undetectable HBV DNA by HC2 assay. Concordant results were obtained for 40 (60.61%) out of these 66 patients by real-time-PCR and HC2 assay with mean viral load of 7.06 ± 1.13 log 10 copies/ml and 6.95 ± 1.08 log 10 copies/ml, respectively. In the remaining 26 patients, HBV DNA was detectable by real-time-PCR in 20 patients (mean HBV DNA level was 3.67 ± 0.72 log 10 copies/ml. However, HBV DNA could not be detectable in six cases by the both assays. The study showed strong correlation (r = 0.915) between real-time-PCR and HC2 assay for the detection and quantification of HBV DNA. HC2 assay may be used as an alternative to real-time-PCR for CHB patients. How to cite this article: Majid F, Jahan M, Moben AL, Tabassum S. Comparison of Hybrid Capture 2 Assay with Real-time-PCR for Detection and Quantitation of Hepatitis B Virus DNA. Euroasian J Hepato-Gastroenterol 2014;4(1):31-35.

Detection of selected intestinal helminths and protozoa at Hospital Universiti Sains Malaysia using multiplex real-time PCR.

PubMed

Basuni, M; Mohamed, Z; Ahmad, M; Zakaria, N Z; Noordin, R

2012-09-01

Intestinal parasites are the causative agents of a number of important human infections in developing countries. The objective of this study was to determine the prevalence of selected helminths and protozoan infections among patients admitted with gastrointestinal disorders at Hospital Universiti Sains Malaysia, Kelantan, Malaysia using multiplex real-time PCR. In addition microscopic examination was also performed following direct smear, zinc sulphate concentration and Kato-Katz thick smear techniques; and the presence of protozoan parasites was confirmed using trichrome and acid-fast stains. Of the 225 faecal samples analysed, 26.2% were positive for intestinal parasites by the multiplex real-time PCR, while 5.3% were positive by microscopy. As compared to microscopy, the multiplex real-time PCR detected 5.8 and 4.5 times more positives for the selected helminth and protozoan infections respectively. Among the selected helminths detected in this study, hookworm was the most prevalent by real-time PCR, while Ascaris lumbricoides was detected the most by microscopy. Meanwhile, among the selected protozoa detected in this study, Entamoeba histolytica was the most prevalent by real-time PCR, however microscopy detected equal number of cases with E. histolytica and Giardia lamblia. This study showed that real-time PCR can be used to obtain a more accurate prevalence data on intestinal helminths and protozoa.

Optimized Real-Time Control of Combined Sewerage Systems: Two Case Studies (Proceedings Paper)

EPA Science Inventory

The paper presents results of two case studies of Real-Time Control (RTC) alternatives evaluations that were conducted on portions of sewerage systems near Paris, France and in Quebec City, Canada, respectively. The studies were performed at real-scale demonstration sites. RTC al...

Technology Transition Pull: A Case Study of Rate Monotonic Analysis (Part 2).

DTIC Science & Technology

1995-04-01

met in software-intensive real - time systems . RMA allows engineers to under- stand and predict the timing behavior of real-time software to a degree...not previously possible. The Rate Monotonic Analysis for Real - Time Systems (RMARTS) Project at the SEI has dem- onstrated how to design, implement...troubleshoot, and maintain real - time systems using RMA. From 1987-1992, the project worked to develop the technology and encourage its widespread

Ends Versus Means: A Critical Analysis of the Persian Gulf Crisis (1987- 1988)

DTIC Science & Technology

1990-08-01

readily apparent that a 12 gjunX ýjM 1Q§ (Washington: National Archives and Records Service, uFo , 1981), p. 197. 13 Snyder, p. 81. 18 whole host of...the consequences of an Iranian victory in the Gulf War. . . . However, the Soviets also seek to avoid alienating Iran and, if possible, hope to improve

The Electrochemistry of Organophosphorus Compounds.

DTIC Science & Technology

1988-01-20

of hydrogen on the electrode surface. Mechanistkc views are further developed with the addition of water resulting in the formation of...the exclusive vlide product. Furthermore, carbonvl compounds were added to the electrolyses to react with the electrochemically-generated ylides via...the Wittig reaction. The resulting olefins were found to catalytically isomerize from the Z isomer to the E isomer upon reduction. The role of water

Wave-Current Conditions and Navigation Safety at an Inlet Entrance

DTIC Science & Technology

2015-06-26

effects of physical processes. Wave simulations with refraction, shoaling, and breaking provide estimates of wave-related parameters of interest to...summer and winter months and to better understand the cause- effect relationship between navigability conditions at Tillamook Inlet and characteristics of...the Coriolis force, wind stress, wave stress, bottom stress, vegetation flow drag, bottom friction, wave roller, and turbulent diffusion. Governing

The United States Army Medical Department Journal. October-December 2007

DTIC Science & Technology

2007-12-01

weapons assembly/disassembly and functions check; individual chemical, biological , radiological, nuclear and high-explosive defense; and the operation of...the 40 Army Warrior Tasks and 11 Battle Drills, to include advanced land navigation training; weapons familiarization and qualification; convoy...operations; chemical, biological , radiological, nuclear and high- explosive defense; and squad and platoon-patrol exercises in both woodland and urban

Predicting Commissary Store Success

DTIC Science & Technology

2014-12-01

that make any retail store successful: the number of shoppers, the price differential between a store and its competition, and the number of...the planning of future stores to maximize the return on taxpayers’ investment. 3 II. BACKGROUND A. COMMISSARY HISTORY Commissary stores began...Defense Commissary Agency (DeCA) in 1990. DeCA currently oversees all commissary stores ( History , n.d.). B. COMMISSARY REGULATIONS Top-level

Privacy-Enhancing Technologies for the Internet

DTIC Science & Technology

1997-01-01

http://www.communities.com/paper/swamp.html 7 David Chaum , ``Untraceable Electronic Mail, Return addresses, and Digital Pseudonyms,’’ Communications of...the ACM, February 1981, vol. 24 no. 2. http://www.eskimo.com/~weidai/mix-net.txt 8 David Chaum , ``Blind Signatures for Untraceable Payments...Privacy-enhancing technologies for the Internet Ian Goldberg David Wagner Eric Brewer University of California, Berkeley {iang,daw,brewer

76 FR 51099 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Order Granting...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-17

.... For each contract month, CBOE will determine the at-the-money strike price. The Exchange will then select the at-the-money and out- of-the money series with non-zero bid prices and determine the midpoint... that the further away that series is from the at-the-money strike, the less weight that is accorded to...

76 FR 32000 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Order Granting...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-02

.... For each contract month, CBOE will determine the at-the-money strike price. The Exchange will then select the at-the-money and out- of-the money series with non-zero bid prices and determine the midpoint... that the further away that series is from the at-the-money strike, the less weight that is accorded to...

Recovering Signals from Optical Fiber Interferometric Sensors

DTIC Science & Technology

1991-06-01

GROUP SUB* GROUp Demodulation-, optical fiber, fi ber optic, sensors, passive -homodyne demodulation, symmetric demodul -ation, asymmetric demodulation...interferomeler without feedback control or modulation ofl th laser itself and without requiring the use of electronics withi -n the interferometer. One of...the 3x3 coupler permits Passive Homodyne Demodulation -of the phase-modulated signals provided by the interferometcr without feedback control or

Probabilistic-Based Modeling and Simulation Assessment

DTIC Science & Technology

2010-06-01

developed to determine the relative importance of structural components of the vehicle under differnet crash and blast scenarios. With the integration of...the vehicle under different crash and blast scenarios. With the integration of the high fidelity neck and head model, a methodology to calculate the...parameter variability, correlation, and multiple (often competing) failure metrics. Important scenarios include vehicular collisions, blast /fragment

Disordered Quantum Gases and Spin-Dependent Lattices

DTIC Science & Technology

2013-07-07

regarding the role of disorder in many-particle quantum systems, such as superconductors and electronic solids. These issues are of great technological...REPORT Disordered Quantum Gases and Spin-Dependent Lattices 14. ABSTRACT 16. SECURITY CLASSIFICATION OF: This grant supported the first realization of...the disordered Bose-Hubbard models using ultra-cold atoms trapped in a disordered optical lattice. Several critical questions regarding this crucial

EMC (Electromagnetic Compatibility) Standards Handbook. Revision 4,

DTIC Science & Technology

1982-11-01

report was prepared by the lIT Research Institute as part of AF Project 649E under Contract F-19628-80-C-0042 with the Electronic Systems Division of...the Air Pbrce Systems Command in support of the DoD Electromagnetic Compatibility Analysis Center, Annapolis, Maryland. This report has been reviewed...3-1 "JVDE Organizations .. .0 . . . . . . . . . . . . . . . . . . . . . 3 1 VDE Testing Station

National Security Cutter: Enhanced Oversight Needed to Ensure Problems Discovered during Testing and Operations Are Addressed

DTIC Science & Technology

2016-01-01

148 Note: Shaded rows are deficiencies that were known prior to IOT&E, but not repaired. aSea state refers to the height, period, and character of...the cutter to transmit data. Source: GAO analysis of Navy and Coast Guard data. | GAO-16-148 aSea state refers to the height, period, and character of

Real-time teleophthalmology versus face-to-face consultation: A systematic review.

PubMed

Tan, Irene J; Dobson, Lucy P; Bartnik, Stephen; Muir, Josephine; Turner, Angus W

2017-08-01

Introduction Advances in imaging capabilities and the evolution of real-time teleophthalmology have the potential to provide increased coverage to areas with limited ophthalmology services. However, there is limited research assessing the diagnostic accuracy of face-to-face teleophthalmology consultation. This systematic review aims to determine if real-time teleophthalmology provides comparable accuracy to face-to-face consultation for the diagnosis of common eye health conditions. Methods A search of PubMed, Embase, Medline and Cochrane databases and manual citation review was conducted on 6 February and 7 April 2016. Included studies involved real-time telemedicine in the field of ophthalmology or optometry, and assessed diagnostic accuracy against gold-standard face-to-face consultation. The revised quality assessment of diagnostic accuracy studies (QUADAS-2) tool assessed risk of bias. Results Twelve studies were included, with participants ranging from four to 89 years old. A broad number of conditions were assessed and include corneal and retinal pathologies, strabismus, oculoplastics and post-operative review. Quality assessment identified a high or unclear risk of bias in patient selection (75%) due to an undisclosed recruitment processes. The index test showed high risk of bias in the included studies, due to the varied interpretation and conduct of real-time teleophthalmology methods. Reference standard risk was overall low (75%), as was the risk due to flow and timing (75%). Conclusion In terms of diagnostic accuracy, real-time teleophthalmology was considered superior to face-to-face consultation in one study and comparable in six studies. Store-and-forward image transmission coupled with real-time videoconferencing is a suitable alternative to overcome poor internet transmission speeds.

Clinical usefulness of augmented reality using infrared camera based real-time feedback on gait function in cerebral palsy: a case study

PubMed Central

Lee, Byoung-Hee

2016-01-01

[Purpose] This study investigated the effects of real-time feedback using infrared camera recognition technology-based augmented reality in gait training for children with cerebral palsy. [Subjects] Two subjects with cerebral palsy were recruited. [Methods] In this study, augmented reality based real-time feedback training was conducted for the subjects in two 30-minute sessions per week for four weeks. Spatiotemporal gait parameters were used to measure the effect of augmented reality-based real-time feedback training. [Results] Velocity, cadence, bilateral step and stride length, and functional ambulation improved after the intervention in both cases. [Conclusion] Although additional follow-up studies of the augmented reality based real-time feedback training are required, the results of this study demonstrate that it improved the gait ability of two children with cerebral palsy. These findings suggest a variety of applications of conservative therapeutic methods which require future clinical trials. PMID:27190489

Development of decision support systems for real-time freeway traffic routing : volume II.

DOT National Transportation Integrated Search

1998-01-01

Real-time traffic flow routing is a promising approach to alleviating congestion. Existing approaches to developing real-time routing strategies, however, have limitations. This study explored the potential for using case-based reasoning (CBR), an em...

On the origin of reflectance-anisotropy oscillations during GaAs (0 0 1) homoepitaxy

NASA Astrophysics Data System (ADS)

Ortega-Gallegos, J.; Guevara-Macías, L. E.; Ariza-Flores, A. D.; Castro-García, R.; Lastras-Martínez, L. F.; Balderas-Navarro, R. E.; López-Estopier, R. E.; Lastras-Martínez, A.

2018-05-01

We report on the first spectroscopic study of reflectance-anisotropy (RA) oscillations during molecular beam epitaxy (MBE) GaAs homoepitaxy. Real-time RA spectra measured during epitaxial growth were carried out with a recently developed rapid RA multichannel spectrometer with 100 ms per spectrum acquisition time. An analysis of the time-resolved RA spectra shows that RA oscillations are mostly due to the periodic modulation of the surface orthorhombic strain associated to surface reconstruction. Results reported here demonstrate the power of real-time RA spectroscopy as a probe for the study of epitaxial growth processes. In particular, given its sub monolayer surface-strain sensitivity, RA spectroscopy results a very convenient tool to study epitaxial growth mechanisms in real-time with sub monolayer resolution. This capability allows for real-time RA spectroscopy to be used as a probe for the in situ, real-time control of epitaxial growth, with the additional advantage of operating in higher pressure systems such as CVD, where RHEED monitoring cannot be implemented.

Voyager planetary radio astronomy at neptune.

PubMed

Warwick, J W; Evans, D R; Peltzer, G R; Peltzer, R G; Romig, J H; Sawyer, C B; Riddle, A C; Schweitzer, A E; Desch, M D; Kaiser, M L; Farrell, W M; Carr, T D; de Pater, I; Staelin, D H; Gulkis, S; Poynter, R L; Boischot, A; Genova, F; Leblanc, Y; Lecacheux, A; Pedersen, B M; Zarka, P

1989-12-15

Detection of very intense short radio bursts from Neptune was possible as early as 30 days before closest approach and at least 22 days after closest approach. The bursts lay at frequencies in the range 100 to 1300 kilohertz, were narrowband and strongly polarized, and presumably originated in southern polar regions ofthe planet. Episodes of smooth emissions in the frequency range from 20 to 865 kilohertz were detected during an interval of at least 10 days around closest approach. The bursts and the smooth emissions can be described in terms of rotation in a period of 16.11 +/- 0.05 hours. The bursts came at regular intervals throughout the encounter, including episodes both before and after closest approach. The smooth emissions showed a half-cycle phase shift between the five episodes before and after closest approach. This experiment detected the foreshock of Neptune's magnetosphere and the impacts of dust at the times of ring-plane crossings and also near the time of closest approach. Finally, there is no evidence for Neptunian electrostatic discharges.

Can You Help Me with My Pitch? Studying a Tool for Real-Time Automated Feedback

ERIC Educational Resources Information Center

Schneider, Jan; Borner, Dirk; van Rosmalen, Peter; Specht, Marcus

2016-01-01

In our pursue to study effective real-time feedback in Technology Enhanced Learning, we developed the Presentation Trainer, a tool designed to support the practice of nonverbal communication skills for public speaking. The tool tracks the user's voice and body to analyze her performance, and selects the type of real-time feedback to be presented.…

Real-time fMRI: a tool for local brain regulation.

PubMed

Caria, Andrea; Sitaram, Ranganatha; Birbaumer, Niels

2012-10-01

Real-time fMRI permits simultaneous measurement and observation of brain activity during an ongoing task. One of the most challenging applications of real-time fMRI in neuroscientific and clinical research is the possibility of acquiring volitional control of localized brain activity using real-time fMRI-based neurofeedback protocols. Real-time fMRI allows the experimenter to noninvasively manipulate brain activity as an independent variable to observe the effects on behavior. Real-time fMRI neurofeedback studies demonstrated that learned control of the local brain activity leads to specific changes in behavior. Here, the authors describe the implementation and application of real-time fMRI with particular emphasis on the self-regulation of local brain activity and the investigation of brain-function relationships. Real-time fMRI represents a promising new approach to cognitive neuroscience that could complement traditional neuroimaging techniques by providing more causal insights into the functional role of circumscribed brain regions in behavior.

Comparison of real-time SYBR green dengue assay with real-time taqman RT-PCR dengue assay and the conventional nested PCR for diagnosis of primary and secondary dengue infection

PubMed Central

Paudel, Damodar; Jarman, Richard; Limkittikul, Kriengsak; Klungthong, Chonticha; Chamnanchanunt, Supat; Nisalak, Ananda; Gibbons, Robert; Chokejindachai, Watcharee

2011-01-01

Background: Dengue fever and dengue hemorrhagic fever are caused by dengue virus. Dengue infection remains a burning problem of many countries. To diagnose acute dengue in the early phase we improve the low cost, rapid SYBR green real time assay and compared the sensitivity and specificity with real time Taqman® assay and conventional nested PCR assay. Aims: To develop low cost, rapid and reliable real time SYBR green diagnostic dengue assay and compare with Taqman real-time assay and conventional nested PCR (modified Lanciotti). Materials and Methods: Eight cultured virus strains were diluted in tenth dilution down to undetectable level by the PCR to optimize the primer, temperature (annealing, and extension and to detect the limit of detection of the assay. Hundred and ninety three ELISA and PCR proved dengue clinical samples were tested with real time SYBR® Green assay, real time Taqman® assay to compare the sensitivity and specificity. Results: Sensitivity and specificity of real time SYBR® green dengue assay (84% and 66%, respectively) was almost comparable to those (81% and 74%) of Taqman real time PCR dengue assay. Real time SYBR® green RT-PCR was equally sensitive in primary and secondary infection while real time Taqman was less sensitive in the secondary infection. Sensitivity of real time Taqman on DENV3 (87%) was equal to SYBR green real time PCR dengue assay. Conclusion: We developed low cost rapid diagnostic SYBR green dengue assay. Further study is needed to make duplex primer assay for the serotyping of dengue virus. PMID:22363089

Comparison of nested-multiplex, Taqman & SYBR Green real-time PCR in diagnosis of amoebic liver abscess in a tertiary health care institute in India

PubMed Central

Dinoop, K.P.; Parija, Subhash Chandra; Mandal, Jharna; Swaminathan, R.P.; Narayanan, P.

2016-01-01

Background & objectives: Amoebiasis is a common parasitic infection caused by Entamoeba histolytica and amoebic liver abscess (ALA) is the most common extraintestinal manifestation of amoebiasis. The aim of this study was to standardise real-time PCR assays (Taqman and SYBR Green) to detect E. histolytica from liver abscess pus and stool samples and compare its results with nested-multiplex PCR. Methods: Liver abscess pus specimens were subjected to DNA extraction. The extracted DNA samples were subjected to amplification by nested-multiplex PCR, Taqman (18S rRNA) and SYBR Green real-time PCR (16S-like rRNA assays to detect E. histolytica/E. dispar/E. moshkovskii). The amplification products were further confirmed by DNA sequence analysis. Receiver operator characteristic (ROC) curve analysis was done for nested-multiplex and SYBR Green real-time PCR and the area under the curve was calculated for evaluating the accuracy of the tests to dignose ALA. Results: In all, 17, 19 and 25 liver abscess samples were positive for E. histolytica by nested-multiplex PCR, SYBR Green and Taqman real-time PCR assays, respectively. Significant differences in detection of E. histolytica were noted in the real-time PCR assays evaluated (P<0.0001). The nested-multiplex PCR, SYBR Green real-time PCR and Taqman real-time PCR evaluated showed a positivity rate of 34, 38 and 50 per cent, respectively. Based on ROC curve analysis (considering Taqman real-time PCR as the gold standard), it was observed that SYBR Green real-time PCR was better than conventional nested-multiplex PCR for the diagnosis of ALA. Interpretation & conclusions: Taqman real-time PCR targeting the 18S rRNA had the highest positivity rate evaluated in this study. Both nested multiplex and SYBR Green real-time PCR assays utilized were evaluated to give accurate results. Real-time PCR assays can be used as the gold standard in rapid and reliable diagnosis, and appropriate management of amoebiasis, replacing the conventional molecular methods. PMID:26997014

Evaluation of propidium monoazide real-time PCR for enumeration of probiotic lactobacilli microencapsulated in calcium alginate beads.

PubMed

Oketič, K; Matijašić, B Bogovič; Obermajer, T; Radulović, Z; Lević, S; Mirković, N; Nedović, V

2015-01-01

The aim of the study was to evaluate real-time PCR coupled with propidium monoazide (PMA) treatment for enumeration of microencapsulated probiotic lactobacilli microencapsulated in calcium alginate beads. Lactobacillus gasseri K7 (CCM 7710) and Lactobacillus delbrueckii subsp. bulgaricus (CCM 7712) were analysed by plate counting and PMA real-time PCR during storage at 4 °C for 90 days. PMA was effective in preventing PCR amplification of the target sequences of DNA released from heat-compromised bacteria. The values obtained by real-time PCR of non-treated samples were in general higher than those obtained by real-time PCR of PMA-treated samples or by plate counting, indicating the presence of sub-lethally injured cells. This study shows that plate count could not be completely replaced by culture independent method PMA real-time PCR for enumeration of probiotics, but may rather complement the well-established plate counting, providing useful information about the ratio of compromised bacteria in the samples.

Real-time PCR for the early detection and quantification of Coxiella burnetii as an alternative to the murine bioassay.

PubMed

Howe, Gerald B; Loveless, Bonnie M; Norwood, David; Craw, Philip; Waag, David; England, Marilyn; Lowe, John R; Courtney, Bernard C; Pitt, M Louise; Kulesh, David A

2009-01-01

Real-time PCR was used to analyze archived blood from non-human primates (NHP) and fluid samples originating from a well-controlled Q fever vaccine efficacy trial. The PCR targets were the IS1111 element and the com1 gene of Coxiella burnetii. Data from that previous study were used to evaluate real-time PCR as an alternative to the use of sero-conversion by mouse bioassay for both quantification and early detection of C. burnetii bacteria. Real-time PCR and the mouse bioassay exhibited no statistical difference in quantifying the number of microorganisms delivered in the aerosol challenge dose. The presence of C. burnetii in peripheral blood of non-human primates was detected by real-time PCR as early after exposure as the mouse bioassay with results available within hours instead of weeks. This study demonstrates that real-time PCR has the ability to replace the mouse bioassay to measure dosage and monitor infection of C. burnetii in a non-human primate model.

Demonstrating the Value of Near Real-time Satellite-based Earth Observations in a Research and Education Framework

NASA Astrophysics Data System (ADS)

Chiu, L.; Hao, X.; Kinter, J. L.; Stearn, G.; Aliani, M.

2017-12-01

The launch of GOES-16 series provides an opportunity to advance near real-time applications in natural hazard detection, monitoring and warning. This study demonstrates the capability and values of receiving real-time satellite-based Earth observations over a fast terrestrial networks and processing high-resolution remote sensing data in a university environment. The demonstration system includes 4 components: 1) Near real-time data receiving and processing; 2) data analysis and visualization; 3) event detection and monitoring; and 4) information dissemination. Various tools are developed and integrated to receive and process GRB data in near real-time, produce images and value-added data products, and detect and monitor extreme weather events such as hurricane, fire, flooding, fog, lightning, etc. A web-based application system is developed to disseminate near-real satellite images and data products. The images are generated with GIS-compatible format (GeoTIFF) to enable convenient use and integration in various GIS platforms. This study enhances the capacities for undergraduate and graduate education in Earth system and climate sciences, and related applications to understand the basic principles and technology in real-time applications with remote sensing measurements. It also provides an integrated platform for near real-time monitoring of extreme weather events, which are helpful for various user communities.

Distributed Systems: Interconnection and Fault Tolerance Studies

DTIC Science & Technology

1992-01-01

real - time operating system , a number of new techniques have to be...problem is at the heart of a successful implementation of a real - time operating system in a distributed environment. Our studies of the issues...land, College Park MD 20742, January 1991. [i1] 6 lafur Gudmundsson, Daniel Moss6, Ashok K. Agrawala, and Satish K. Tripathi. MARUTI a hard real - time operating system .

Comparison of Hybrid Capture 2 Assay with Real-time-PCR for Detection and Quantitation of Hepatitis B Virus DNA

PubMed Central

Jahan, Munira; Lutful Moben, Ahmed; Tabassum, Shahina

2014-01-01

ABSTRACT Background Both real-time-polymerase chain reaction (PCR) and hybrid capture 2 (HC2) assay can detect and quantify hepatitis B virus (HBV) DNA. However, real-time-PCR can detect a wide range of HBV DNA, while HC2 assay could not detect lower levels of viremia. The present study was designed to detect and quantify HBV DNA by real-time-PCR and HC2 assay and compare the quantitative data of these two assays. Materials and methods A cross-sectional study was conducted in between July 2010 and June 2011. A total of 66 serologically diagnosed chronic hepatitis B (CHB) patients were selected for the study. Real-time-PCR and HC2 assay was done to detect HBV DNA. Data were analyzed by statistical Package for the social sciences (SPSS). Results Among 66 serologically diagnosed chronic hepatitis B patients 40 (60.61%) patients had detectable and 26 (39.39%) had undetectable HBV DNA by HC2 assay. Concordant results were obtained for 40 (60.61%) out of these 66 patients by real-time-PCR and HC2 assay with mean viral load of 7.06 ± 1.13 log10 copies/ml and 6.95 ± 1.08 log10 copies/ml, respectively. In the remaining 26 patients, HBV DNA was detectable by real-time-PCR in 20 patients (mean HBV DNA level was 3.67 ± 0.72 log10 copies/ml. However, HBV DNA could not be detectable in six cases by the both assays. The study showed strong correlation (r = 0.915) between real-time-PCR and HC2 assay for the detection and quantification of HBV DNA. Conclusion HC2 assay may be used as an alternative to real-time-PCR for CHB patients. How to cite this article: Majid F, Jahan M, Moben AL, Tabassum S. Comparison of Hybrid Capture 2 Assay with Real-time-PCR for Detection and Quantitation of Hepatitis B Virus DNA. Euroasian J Hepato-Gastroenterol 2014;4(1):31-35. PMID:29264316

FY*X real-time polymerase chain reaction with melting curve analysis associated with a complete one-step real-time FY genotyping.

PubMed

Ansart-Pirenne, H; Martin-Blanc, S; Le Pennec, P-Y; Rouger, P; Cartron, J-P; Tournamille, C

2007-02-01

The Duffy (FY) blood group system is controlled by four major alleles: FY*A and FY*B, the Caucasian common alleles, encoding Fy(a) and Fy(b) antigens; FY*X allele responsible for a poorly expressed Fy(b) antigen, and FY*Fy a silent predominant allele among Black population. Despite the recent development of a real-time fluorescent polymerase chain reaction (PCR) method for FY genotyping FY*X genotyping has not been described by this method. This study focused on the real-time FY*X genotyping development associated with a complete, one-step real-time FY genotyping, based on fluorescence resonance energy transfer (FRET) technology. Seventy-two blood samples from Fy(a+b-) Caucasian blood donors were studied by real-time PCR only. Forty-seven Caucasian and Black individual blood samples, referred to our laboratory, were studied by PCR-RFLP and real-time PCR. For each individual, the result of the genotype was compared to the known phenotype. The FY*X allele frequency calculated in an Fy(a+b-) Caucasian blood donors population was 0.014. With the Caucasian and Black patient samples we found a complete correlation between PCR-RFLP and the real-time PCR method whatever the alleles combination tested. When the known phenotype was not correlated to FY*X genotype, the presence of the Fy(b) antigen was always confirmed by adsorption-elution. The real-time technology method is rapid and accurate for FY genotyping. From now, we are able to detect the FY*X allele in all the alleles combinations studied. Regarding its significant frequency, the detection of the FY*X allele is useful for the correct typing of blood donors and recipients considering the therapeutic use of blood units and the preparation of test red blood cells for antibody screening.

Real-Time Confocal Imaging Of The Living Eye

NASA Astrophysics Data System (ADS)

Jester, James V.; Cavanagh, H. Dwight; Essepian, John; Shields, William J.; Lemp, Michael A.

1989-12-01

In 1986, we adapted the Tandem Scanning Reflected Light Microscope of Petran and Hadraysky to permit non-invasive, confocal imaging of the living eye in real-time. We were first to obtain stable, confocal optical sections in vivo, from human and animal eyes. Using confocal imaging systems we have now studied living, normal volunteers, rabbits, cats and primates sequentially, non-invasively, and in real-time. The continued development of real-time confocal imaging systems will unlock the door to a new field of cell biology involving for the first time the study of dynamic cellular processes in living organ systems. Towards this end we have concentrated our initial studies on three areas (1) evaluation of confocal microscope systems for real-time image acquisition, (2) studies of the living normal cornea (epithelium, stroma, endothelium) in human and other species; and (3) sequential wound-healing responses in the cornea in single animals to lamellar-keratectomy injury (cellular migration, inflammation, scarring). We believe that this instrument represents an important, new paradigm for research in cell biology and pathology and that it will fundamentally alter all experimental and clinical approaches in future years.

Congestion relief by travel time minimization in near real time : Detroit area I-75 corridor study.

DOT National Transportation Integrated Search

2008-12-01

"This document summarizes the activities concerning the project: Congestion Relief by : Travel Time Minimization in Near Real Time -- Detroit Area I-75 Corridor Study since : the inception of the project (Nov. 22, 2006 through September 30, 2008). : ...

A Study of Normal Shock-Wave Turbulent Boundary-Layer Interactions at Mach Numbers of 1.3, 1.4 and 1.5.

DTIC Science & Technology

1982-10-01

Veigas 13used a third technique which was to hold the normal shock wave steady in a supersonic tube by the adjustment of a conical choke downstream of...the equilibrium functioii E (equation (3) as tie eqoi ihri:’ fl -it I lows of East, Sawyer and Nash 2 8 . Although the maximum values of ti wakce :, i...f.. ..l.. .. .. ..t.. fl iC!alaCC CCCCCCCCt t CCCCCifllt CCCCCCCCit C C--- ---- -- C A CCC5C tCC C NC C - f CC1S $ C C A * E~ - - C 2

Innovative Seismic Array Analysis for Studies of Wave Propagation in the Earth

DTIC Science & Technology

1999-04-30

station signal power can be written as 0.5 - 3.5 Hz. 2.0 -14.0 Hz. Pmg(f,t,u) = \\d\\ 2-tr[C(f,t,u)], (6) where tr is the trace of...the matrix and d is an A^ X 1 vector N of station weights such that 2 d„ = 1. We will be using uniform weighting such that d„ = \\IN. The power of... stations SEH, SWH, and NH. Wpw 2 ukm{ uk , Uj) X m( uk , Uj) ( uk , Uj) &4 (9) where m( uk , Uj) 0 S(f, t, uk , M,.) < 0.9Speak (/, t)f S(f,

High Efficiency Transverse D. C. Electron Beams.

DTIC Science & Technology

1984-10-01

22c. OFFICE SYM yer(Include A 4VCode, 01’ e, V.2 DD FORM 1473, 83 APR’ EDITION OF I JAN 73 IS OBSOLETE. " * . TCUIV ( 4 tUIFICATION OF THIS PAGE This...Reflectivities were R, -> 99.17 (FI 2 Laser output rxtwer ofthe 6 149 9-A fig I I iransition aisa function of and ~ 935% a 4 0 A.Usin thi laer stup

Responding to climate change: A toolbox of management strategies

Treesearch

D. Cole; N.L. Stephenson; C.I. Millar

2010-01-01

Climate change and its effects are writ large across the landscape and in the natural and cultural heritage ofparks and wilderness. They always have been and always will be. The sculpted walls of Yosemite National Park and the jagged scenery ofthe Sierra Nevada wilderness would not be as spectacular if periods of glaciation had not been followed by periods of...

Regional CMS Modeling: Southwest Florida Gulf Coast

DTIC Science & Technology

2016-05-01

by Kelly R. Legault and Tanya M. Beck PURPOSE: This Coastal and Hydraulics Engineering technical note (CHETN) describes a regional application of...the U.S. Army Corps of Engineers (USACE) Engineer Research and Development Center (ERDC) Coastal Modeling System (CMS). This application spans three...Active federal projects include the Pinellas County Shore Protection Project (SPP), Tampa Harbor Deeping Project, Manatee County SPP at Anna Maria

JPRS Report, Science & Technology, Europe

DTIC Science & Technology

1992-03-12

the Chemical Industry Fund. However, the recent successes of this privately- sponsored research do present an ecological problem. Although the...SAMW issued medical- ethical guidelines prohibiting the manip- ulation of the genotype of gametes and embryos. In 1986, the Swiss Academies for...Concerning Large Fuel Burning Plants which took effect in 1983 triggered an " ecological renewal program" with mandatory limits based on state- of-the

A Layered Social and Operational Network Analysis

DTIC Science & Technology

2007-03-01

organizations, networks and individuals” (OPOTUS, 2006: 5). These transnational threats, which compromise the security of the US , consist of...The focus of criminal groups is money ; the trafficking of 2-7 drugs or people, the money laundering , and the corruption are a means to generate...assassination is used (National Defense University, 1999:250). 2-8 Economic and industrial espionage, bank fraud, financial market manipulation, and

Data Mining the Corporate Dental System of USA DENTAC Fort Bragg

DTIC Science & Technology

2016-06-10

Data Mining the Corporate Dental System of USA DENTAC Fort Bragg FREDWIN HOLOMON, D.D.S. B.S. University of...AEGD Program Director ABSTRACT Statement of the problem: Dental wellness has not reached optimum levels at Fort Bragg after implementation of...the Go First Class Program. Purpose: To examine the Go First Class Program’s influence upon dental wellness and readiness. Materials and Methods

Spaced Armor

DTIC Science & Technology

1950-11-20

the skirting plate of the minimum thickness capable of producing the desired effect upon the projectae . There is a sound reason for this approach...obliquity. As part of a program aimed at improving the performance of carbide cored projectiles, the Watertown Arsenal arranged, some years ago, trials of...the inter- action of kinetic energy projectiles and spaced armor combinations. The . details of the ballistic testing program were laid out jointly by

Picoradio: Communication/Computation Piconodes for Sensor Networks

DTIC Science & Technology

2003-01-02

diagram of PicoNode III, or Quark node. It is made from two custom chips, Strange RF and Charm digital processor , and is complemented by a set of...the chipset comprising of Strange (analog OOK transceiver) and Charm (digital processor ) chips. 44 Figure 33: System block diagram of the Quark node...19 2.B PICONODE II - TWO-CHIP PICONODE IMPLEMENTATION ......................................... 21 2.B.1 Baseband processor (BBP

Development of Medical Technology for Contingency Response to Marrow Toxic Agents

DTIC Science & Technology

2012-04-26

Biodefense Strategy, Practice, and Science • a manuscript in press for Leukemia on response to the Fukushima Daiichi nuclear power plant incident • a... awareness of the Transplant Centerl Contingency Planning Committee and educate the transplant community about the critical imp011ance of establishing a...nationwide contingency response plan. Increase understanding ofthe immunologic factors important in HSC transplantation. Create a that facilitates

A Risk-Based Approach for Aerothermal/TPS Analysis and Testing

DTIC Science & Technology

2007-07-01

RTO-EN-AVT-142 17 - 1 A Risk-Based Approach for Aerothermal/ TPS Analysis and Testing Michael J. Wright∗ and Jay H. Grinstead† NASA Ames...of the thermal protection system ( TPS ) is to protect the payload (crew, cargo, or science) from this entry heating environment. The performance of...the TPS is determined by the efficiency and reliability of this system, typically measured

Socioeconomic Representativeness and the Draft

DTIC Science & Technology

1980-06-01

l that the quality of recruits who enter the services ( especiall the Army) is of lover caliber than historically experienced. Proponents of...the "quality" of recruits who enter the services ( especially the Army) is of lower caliber than historically experienced. Proponents of conscription...draft, especially when considering peacetime conscrip- tion. The strength of the argument for the draft was held to be that all eligible men would serve

The Restless Context: Military Institutional Awareness of Social Change

DTIC Science & Technology

1978-04-03

dependence upon theistic explanations for meaning and purpose in life and upsurge in restless irrationality and immersion in cults (to what bases of...the evolution of appropriate missions, weapons systems, mobility and logistics systems, and tactical concepts appropriate for various future combat...and Multinational Corporations Nonconsonant Detente and NATO Deterrence and Detente The Impact of Crises on the Evolution of Strategy and 1’orces in

Task Force on Defense Strategies for Ensuring the Resilience of National Space Capabilities. Executive Summary

DTIC Science & Technology

2017-03-21

March 2017 Task Force on Defense Strategies for Ensuring the Resilience of National Space Capabilities OFFICE OF THE UNDER SECRETARY OF...the Department of Defense. The DSB Task Force on Defense Strategies for Ensuring the Resilience of National Space Capabilities completed its formal...Ensuring the Resilience of National Space Capabilities | i DSB Task Force on Defense Strategies for Ensuring the

Interdiction and Conventional Strategy: Prevailing Perceptions

DTIC Science & Technology

1990-06-01

Andrew Vallance of the RAF Command and Staff College; Air Vice-Marshal R. A. Mason (Ret.); Air Chief Marshal Sir Michael Armitage, Royal College of...The RAND Corporation, N-1743-PAE, September 1981. Dinges, Edward A., and Richard H. Sinnreich, "Battlefield Interdiction: Old Tenn. New Problem...34 Military Affairs, October 1988. McDow, Richard H., Air Interdiction Targeting Priorities, Air University, Maxwell AFB, 1985. Molnar, Alexander

The 2015 National Security Strategy: Authorities, Changes, Issues for Congress

DTIC Science & Technology

2016-02-26

climate change ;  ensure access to shared spaces (expanding cyberspace and including outer space and air and maritime security); and  increase global...hand, one could conclude that these, along with confronting climate change , convey both a wider range of national security challenges in terms of...The 2015 National Security Strategy: Authorities, Changes , Issues for Congress Nathan J. Lucas, Coordinator Section Research Manager Kathleen

Infrared Simulation System (IRSS). Phase I.

DTIC Science & Technology

1977-07-01

73 5-6 Target Characteristics ................................. 100 5-7 Solutions to Target Positioning Equations .................... 117...stiffness and deflections were calculated for the arm. Stiffness require- ments are determined by the equation K - TL G8 ’I where T = applied torque L...framne in terms of a_ and i . The components ofthe seeker axis vector are then equated in the inertiaf framecfor the two methods of transformation

Airpower and the Battle of Khafji: Setting the Record Straight

DTIC Science & Technology

1998-06-01

DISTRIBUTION/AVAILABILITY STATEMENT A PUBLIC RELEASE , 13. SUPPLEMENTARY NOTES 14. ABSTRACT General Norman Schwarzkopf, Commander of...the US Government, Department of Defense, the United States Air Force, or Air University. iii ABSTRACT General Norman Schwarzkopf, Commander of...Commander Gen Norman Schwarzkopf directed Horner to shift the air campaign’s focus to the Iraqi Army— especially the Republican Guard. While some in the

Effect of water repellent preservatives and other wood treatments on restoration and durability of millwork

Treesearch

R. Sam Williams

2001-01-01

This report describes the long-term performance of painted window units that were placed outdoors near Madison, Wisconsin, in 1956. Covered in this report are the effects of the initial water repellent preservative (WRP) treatment during the first 6 years of exposure, a comparison of the water repellent effectiveness (WRE) ofthe WRP with the condition of the windows...

A diameter increment model for Red Fir in California and Southern Oregon

Treesearch

K. Leroy Dolph

1992-01-01

Periodic (10-year) diameter increment of individual red fir trees in Califomia and southern Oregon can be predicted from initial diameter and crown ratio of each tree, site index, percent slope, and aspect of the site. The model actually predicts the natural logarithm ofthe change in squared diameter inside bark between the startand the end of a 10-year growth period....

Comparative Biochemistry and Metabolism. Part 1. Carcinogenesis

DTIC Science & Technology

1981-10-01

qualitatively equivalent to administration of a strong alkylating agent ; this may add another consideration to Roberts’ hypothesis, but ultimately the effect...Removal, Arch. Pathol. 12:186-202. Karran, P., T. Lindahl and B. Griffin, (1979), Adaptive Responses to Alkylating Agents Involves Alterative In Situ of...the Adaptive Response to Alkylating Agents , Nature (Lond.) 280:74-76. Ruchirawat, M., (1974), Relationship Between Metabolism and Toxicity of

Lumped Nonlinear System Analysis with Volterra Series.

DTIC Science & Technology

1980-04-01

f h2 (t-=,t-r )x(r)x(t2)dl d 2 (4- 1 )O0 0 Consider the input signal comprising two unit sinusoidal signals at fre- quencies wa and wb. The input x... 1 - 2 . Nonlinear System Analysis Methods. .............. 2 1 -3. Objectives of the Investigation ....... ............... 6 1 -4. Organization of...the Report ..... ... ................. 9 CHAPTER 2 - VOLTERRA FUNCTIONAL SERIES ...... ............... 12 2 - 1 . Introduction

JPRS Report, Nuclear Developments.

DTIC Science & Technology

1989-09-18

institution had strongly supported the project, which was proposed by experts from the Peruvian Nuclear Energy Institute (IPEN) with the cooperation of...the Science College of the National Engineering Univer- sity. The equipment was obtained under a Peruvian - Argentine agreement, [passage omitted...A football shaped thing was on a stand in the other corner. The official said that was the Islamic bomb and asked if we Pakistanis still denied

A Digital Radio Receiver for Ionospheric Research

DTIC Science & Technology

2006-06-01

amplification, the signals are digitized and then processed by a digital down converter ( DDC ) and decimating low-pass filter. The resultant digital...images. 14. ABSTRACT 15. SUBJECT TERMS 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT UU 18. NUMBER OF PAGES 41 19a. NAME OF...the University of Calgary under a Contributions Agreement contract awarded by the Canadian Space Agency. The present paper follows an earlier article

Economic Development in Indonesia

DTIC Science & Technology

1960-11-21

Deficit Spending and Economic Development..,.. 1 What Follows Rupiah Rehabilitation 9 Private Capital and the Cooperative Movement 14 Some Facets of...the American dollar. 13 PRIVATE CAPITAL AND THE COOPERATIVE MOVEMENT J^he following is a full translation of an article-Wägten by R. P. Suroso...bent themselves energetically to the realization of the ideals and principles enunciated in the Joint Declaration, then the cooperative movement can

Polar-Tropical Coupling in the Winter Stratosphere

NASA Astrophysics Data System (ADS)

Scott, R.

2017-12-01

A distinct pattern of enhanced equatorial potential vorticitygradients during QBO westerly anomalies, enhanced subtropicalgradients during QBO easterlies, is used to motivate a new formulationof dynamical coupling between the tropics and winter polar vortexbased on remote transfer of finite amplitude wave activity defined interms of lateral potential vorticity displacements. While the weakpotential vorticity gradients in the surf zone imply laterallyevanescent Rossby waves, transfer of wave activity from the polarvortex edge to the subtropical barrier or to the QBO westerly phaseequatorial gradients arises from nonlocality of potential vorticityinversion and the large horizontal displacements of the vortex edge.Our approach goes beyond the traditional description of the effect ofQBO wind anomalies on linear wave propagation through the stratospherevia wave reflection at the zero wind line; linear wave theory isappealing but neglects the long horizontal and vertical wavelengthsinvolved and the inhomogeneous background potential vorticity. Aparticular issue of outstanding interest is whether and how therelatively shallow QBO anomalies can influence the deep verticallypropagating waves on the edge of the winter stratospheric polarvortex. Process studies with a mechanistic model with prescribed QBOand carefully controlled high-latitude wave forcing are analyzed,guided by a reexamination of meteorological reanalysis, to address howsuch a dynamical linkage may influence in particular the resonantexcitation of the winter vortex, and the occurrence ofvortex-splitting sudden warming events. We quantify the associatedtransfer of wave activity from vortex edge to the tropics, considerunder what conditions this becomes a significant source of easterlymomentum in the driving of the QBO itself, and how the structure ofthe Brewer-Dobson circulation varies in response to the location ofthe QBO westerly winds in any given winter.

Monitoring of Viral Induced Cell Death Using Real Time Cell Analysis

DTIC Science & Technology

2016-11-01

studies have shown that real- time cell analysis (RTCA) platforms such as the xCELLigence can be used to gather quantitative measurements of viral...Teng, Z., Kuang, X., Wang, J., Zhang, X. Real- time cell analysis – A new method for dynamic, quantitative measurement of infectious viruses and...cytopathogenicity. A) Real- time monitoring of BSR cells infected with a 1:10 dilution series of Gan Gan virus. The curve is an average of eight

New Technologies: Real-time Telepathology Systems-Novel Cost-effective Tools for Real-time Consultation and Data Sharing.

PubMed

Siegel, Gabriel; Regelman, Dan; Maronpot, Robert; Rosenstock, Moti; Nyska, Abraham

2017-12-01

Real-time telepathology for use in investigative and regulated preclinical toxicology studies is now feasible. Newly developed microscope-integrated telepathology systems enable geographically remote stakeholders to view the live histopathology slide as seen by the study pathologist within the microscope. Simultaneous online viewing and dialog between study pathologist and remote colleagues is an efficient and cost-effective means for consultation, pathology working groups, and peer review, facilitating good science and economic benefits by enabling more timely and informed clinical decisions.

Improved Short-Term Clock Prediction Method for Real-Time Positioning.

PubMed

Lv, Yifei; Dai, Zhiqiang; Zhao, Qile; Yang, Sheng; Zhou, Jinning; Liu, Jingnan

2017-06-06

The application of real-time precise point positioning (PPP) requires real-time precise orbit and clock products that should be predicted within a short time to compensate for the communication delay or data gap. Unlike orbit correction, clock correction is difficult to model and predict. The widely used linear model hardly fits long periodic trends with a small data set and exhibits significant accuracy degradation in real-time prediction when a large data set is used. This study proposes a new prediction model for maintaining short-term satellite clocks to meet the high-precision requirements of real-time clocks and provide clock extrapolation without interrupting the real-time data stream. Fast Fourier transform (FFT) is used to analyze the linear prediction residuals of real-time clocks. The periodic terms obtained through FFT are adopted in the sliding window prediction to achieve a significant improvement in short-term prediction accuracy. This study also analyzes and compares the accuracy of short-term forecasts (less than 3 h) by using different length observations. Experimental results obtained from International GNSS Service (IGS) final products and our own real-time clocks show that the 3-h prediction accuracy is better than 0.85 ns. The new model can replace IGS ultra-rapid products in the application of real-time PPP. It is also found that there is a positive correlation between the prediction accuracy and the short-term stability of on-board clocks. Compared with the accuracy of the traditional linear model, the accuracy of the static PPP using the new model of the 2-h prediction clock in N, E, and U directions is improved by about 50%. Furthermore, the static PPP accuracy of 2-h clock products is better than 0.1 m. When an interruption occurs in the real-time model, the accuracy of the kinematic PPP solution using 1-h clock prediction product is better than 0.2 m, without significant accuracy degradation. This model is of practical significance because it solves the problems of interruption and delay in data broadcast in real-time clock estimation and can meet the requirements of real-time PPP.

Detection of Brucella spp. in milk from seronegative cows by real-time polymerase chain reaction in the region of Batna, Algeria

PubMed Central

Sabrina, Rabehi; Mossadak, Hamdi Taha; Bakir, Mamache; Asma, Meghezzi; Khaoula, Boushaba

2018-01-01

Aim: The aim of this study was to detect Brucella spp. DNA in milk samples collected from seronegative cows using the real-time polymerase chain reaction (PCR) assay for diagnosis of brucellosis in seronegative dairy cows to prevent transmission of disease to humans and to reduce economic losses in animal production. Materials and Methods: In this study, 65 milk samples were investigated for the detection of Brucella spp. The detection of the IS711 gene in all samples was done by real-time PCR assay by comparative cycle threshold method. Results: The results show that of the 65 DNA samples tested, 2 (3.08%) were positive for Brucella infection. The mean cyclic threshold values of IS711 real-time PCR test were 37.97 and 40.48, indicating a positive reaction. Conclusion: The results of the present study indicated that the real-time PCR appears to offer several advantages over serological tests. For this reason, the real-time PCR should be validated on representative numbers of Brucella-infected and free samples before being implemented in routine diagnosis in human and animal brucellosis for controlling this disease. PMID:29657430

Real-time 3-dimensional contrast-enhanced ultrasound in detecting hemorrhage of blunt renal trauma.

PubMed

Xu, Rui-Xue; Li, Ye-Kuo; Li, Ting; Wang, Sha-Sha; Yuan, Gui-Zhong; Zhou, Qun-Fang; Zheng, Hai-Rong; Yan, Fei

2013-10-01

The objective of this study is to evaluate the diagnostic value of real-time 3-dimensional contrast-enhanced ultrasound in the hemorrhage of blunt renal trauma. Eighteen healthy New Zealand white rabbits were randomly divided into 3 groups. Blunt renal trauma was performed on each group by using minitype striker. Ultrasonography, color Doppler flow imaging, and contrast-enhanced 2-dimensional and real-time 3-dimensional ultrasound were applied before and after the strike. The time to shock and blood pressure were subjected to statistical analysis. Then, a comparative study of ultrasound and pathology was carried out. All the struck kidneys were traumatic. In the ultrasonography, free fluid was found under the renal capsule. In the color Doppler flow imaging, active hemorrhage was not identified. In 2-dimensional contrast-enhanced ultrasound, active hemorrhage of the damaged kidney was characterized. Real-time 3-dimensional contrast-enhanced ultrasound showed a real-time and stereoscopic ongoing bleeding of the injured kidney. The wider the hemorrhage area in 4-dimensional contrast-enhanced ultrasound was, the faster the blood pressure decreased. Real-time 3-dimensional contrast-enhanced ultrasound is a promising noninvasive tool for stereoscopically and vividly detecting ongoing hemorrhage of blunt renal trauma in real time. © 2013.

Real-time simulation of a Doubly-Fed Induction Generator based wind power system on eMEGASimRTM Real-Time Digital Simulator

NASA Astrophysics Data System (ADS)

Boakye-Boateng, Nasir Abdulai

The growing demand for wind power integration into the generation mix prompts the need to subject these systems to stringent performance requirements. This study sought to identify the required tools and procedures needed to perform real-time simulation studies of Doubly-Fed Induction Generator (DFIG) based wind generation systems as basis for performing more practical tests of reliability and performance for both grid-connected and islanded wind generation systems. The author focused on developing a platform for wind generation studies and in addition, the author tested the performance of two DFIG models on the platform real-time simulation model; an average SimpowerSystemsRTM DFIG wind turbine, and a detailed DFIG based wind turbine using ARTEMiSRTM components. The platform model implemented here consists of a high voltage transmission system with four integrated wind farm models consisting in total of 65 DFIG based wind turbines and it was developed and tested on OPAL-RT's eMEGASimRTM Real-Time Digital Simulator.

Multiplex Real-Time PCR Assay for Rapid Detection of Methicillin-Resistant Staphylococci Directly from Positive Blood Cultures

PubMed Central

Wang, Hye-young; Kim, Sunghyun; Kim, Jungho; Park, Soon-Deok

2014-01-01

Methicillin-resistant Staphylococcus aureus (MRSA) is the most prevalent cause of bloodstream infections (BSIs) and is recognized as a major nosocomial pathogen. This study aimed to evaluate a newly designed multiplex real-time PCR assay capable of the simultaneous detection of mecA, S. aureus, and coagulase-negative staphylococci (CoNS) in blood culture specimens. The Real-MRSA and Real-MRCoNS multiplex real-time PCR assays (M&D, Republic of Korea) use the TaqMan probes 16S rRNA for Staphylococcus spp., the nuc gene for S. aureus, and the mecA gene for methicillin resistance. The detection limit of the multiplex real-time PCR assay was 103 CFU/ml per PCR for each gene target. The multiplex real-time PCR assay was evaluated using 118 clinical isolates from various specimen types and a total of 350 positive blood cultures from a continuous monitoring blood culture system. The results obtained with the multiplex real-time PCR assay for the three targets were in agreement with those of conventional identification and susceptibility testing methods except for one organism. Of 350 positive bottle cultures, the sensitivities of the multiplex real-time PCR kit were 100% (166/166 cultures), 97.2% (35/36 cultures), and 99.2% (117/118 cultures) for the 16S rRNA, nuc, and mecA genes, respectively, and the specificities for all three targets were 100%. The Real-MRSA and Real-MRCoNS multiplex real-time PCR assays are very useful for the rapid accurate diagnosis of staphylococcal BSIs. In addition, the Real-MRSA and Real-MRCoNS multiplex real-time PCR assays could have an important impact on the choice of appropriate antimicrobial therapy, based on detection of the mecA gene. PMID:24648566

MNE Scan: Software for real-time processing of electrophysiological data.

PubMed

Esch, Lorenz; Sun, Limin; Klüber, Viktor; Lew, Seok; Baumgarten, Daniel; Grant, P Ellen; Okada, Yoshio; Haueisen, Jens; Hämäläinen, Matti S; Dinh, Christoph

2018-06-01

Magnetoencephalography (MEG) and Electroencephalography (EEG) are noninvasive techniques to study the electrophysiological activity of the human brain. Thus, they are well suited for real-time monitoring and analysis of neuronal activity. Real-time MEG/EEG data processing allows adjustment of the stimuli to the subject's responses for optimizing the acquired information especially by providing dynamically changing displays to enable neurofeedback. We introduce MNE Scan, an acquisition and real-time analysis software based on the multipurpose software library MNE-CPP. MNE Scan allows the development and application of acquisition and novel real-time processing methods in both research and clinical studies. The MNE Scan development follows a strict software engineering process to enable approvals required for clinical software. We tested the performance of MNE Scan in several device-independent use cases, including, a clinical epilepsy study, real-time source estimation, and Brain Computer Interface (BCI) application. Compared to existing tools we propose a modular software considering clinical software requirements expected by certification authorities. At the same time the software is extendable and freely accessible. We conclude that MNE Scan is the first step in creating a device-independent open-source software to facilitate the transition from basic neuroscience research to both applied sciences and clinical applications. Copyright © 2018 Elsevier B.V. All rights reserved.

A Practical Approach to Implementing Real-Time Semantics

NASA Technical Reports Server (NTRS)

Luettgen, Gerald; Bhat, Girish; Cleaveland, Rance

1999-01-01

This paper investigates implementations of process algebras which are suitable for modeling concurrent real-time systems. It suggests an approach for efficiently implementing real-time semantics using dynamic priorities. For this purpose a proces algebra with dynamic priority is defined, whose semantics corresponds one-to-one to traditional real-time semantics. The advantage of the dynamic-priority approach is that it drastically reduces the state-space sizes of the systems in question while preserving all properties of their functional and real-time behavior. The utility of the technique is demonstrated by a case study which deals with the formal modeling and verification of the SCSI-2 bus-protocol. The case study is carried out in the Concurrency Workbench of North Carolina, an automated verification tool in which the process algebra with dynamic priority is implemented. It turns out that the state space of the bus-protocol model is about an order of magnitude smaller than the one resulting from real-time semantics. The accuracy of the model is proved by applying model checking for verifying several mandatory properties of the bus protocol.

Hard real-time closed-loop electrophysiology with the Real-Time eXperiment Interface (RTXI)

PubMed Central

George, Ansel; Dorval, Alan D.; Christini, David J.

2017-01-01

The ability to experimentally perturb biological systems has traditionally been limited to static pre-programmed or operator-controlled protocols. In contrast, real-time control allows dynamic probing of biological systems with perturbations that are computed on-the-fly during experimentation. Real-time control applications for biological research are available; however, these systems are costly and often restrict the flexibility and customization of experimental protocols. The Real-Time eXperiment Interface (RTXI) is an open source software platform for achieving hard real-time data acquisition and closed-loop control in biological experiments while retaining the flexibility needed for experimental settings. RTXI has enabled users to implement complex custom closed-loop protocols in single cell, cell network, animal, and human electrophysiology studies. RTXI is also used as a free and open source, customizable electrophysiology platform in open-loop studies requiring online data acquisition, processing, and visualization. RTXI is easy to install, can be used with an extensive range of external experimentation and data acquisition hardware, and includes standard modules for implementing common electrophysiology protocols. PMID:28557998

Real-time radiography at the NECTAR facility

NASA Astrophysics Data System (ADS)

Bücherl, T.; Lierse von Gostomski, Ch.

2011-09-01

A feasibility study has shown that real-time radiography using fission neutrons is possible at the NECTAR facility, when using an improved detection system for fast variations (Bücherl et al., 2009 [1]). Continuing this study, real-time measurements of slowly varying processes like the water uptake in medium sized trunks (diameter about 12 cm) and of slow periodic processes (e.g. a slowly rotating iron disk) are investigated successfully using the existing detection system.

Real-Time and Post-Processed Georeferencing for Hyperpspectral Drone Remote Sensing

NASA Astrophysics Data System (ADS)

Oliveira, R. A.; Khoramshahi, E.; Suomalainen, J.; Hakala, T.; Viljanen, N.; Honkavaara, E.

2018-05-01

The use of drones and photogrammetric technologies are increasing rapidly in different applications. Currently, drone processing workflow is in most cases based on sequential image acquisition and post-processing, but there are great interests towards real-time solutions. Fast and reliable real-time drone data processing can benefit, for instance, environmental monitoring tasks in precision agriculture and in forest. Recent developments in miniaturized and low-cost inertial measurement systems and GNSS sensors, and Real-time kinematic (RTK) position data are offering new perspectives for the comprehensive remote sensing applications. The combination of these sensors and light-weight and low-cost multi- or hyperspectral frame sensors in drones provides the opportunity of creating near real-time or real-time remote sensing data of target object. We have developed a system with direct georeferencing onboard drone to be used combined with hyperspectral frame cameras in real-time remote sensing applications. The objective of this study is to evaluate the real-time georeferencing comparing with post-processing solutions. Experimental data sets were captured in agricultural and forested test sites using the system. The accuracy of onboard georeferencing data were better than 0.5 m. The results showed that the real-time remote sensing is promising and feasible in both test sites.

Real-time three-dimensional transesophageal echocardiography in the assessment of mechanical prosthetic mitral valve ring thrombosis.

PubMed

Ozkan, Mehmet; Gürsoy, Ozan Mustafa; Astarcıoğlu, Mehmet Ali; Gündüz, Sabahattin; Cakal, Beytullah; Karakoyun, Süleyman; Kalçık, Macit; Kahveci, Gökhan; Duran, Nilüfer Ekşi; Yıldız, Mustafa; Cevik, Cihan

2013-10-01

Although 2-dimensional (2D) transesophageal echocardiography (TEE) is the gold standard for the diagnosis of prosthetic valve thrombosis, nonobstructive clots located on mitral valve rings can be missed. Real-time 3-dimensional (3D) TEE has incremental value in the visualization of mitral prosthesis. The aim of this study was to investigate the utility of real-time 3D TEE in the diagnosis of mitral prosthetic ring thrombosis. The clinical outcomes of these patients in relation to real-time 3D transesophageal echocardiographic findings were analyzed. Of 1,263 patients who underwent echocardiographic studies, 174 patients (37 men, 137 women) with mitral ring thrombosis detected by real-time 3D TEE constituted the main study population. Patients were followed prospectively on oral anticoagulation for 25 ± 7 months. Eighty-nine patients (51%) had thrombi that were missed on 2D TEE and depicted only on real-time 3D TEE. The remaining cases were partially visualized with 2D TEE but completely visualized with real-time 3D TEE. Thirty-seven patients (21%) had thromboembolism. The mean thickness of the ring thrombosis in patients with thromboembolism was greater than that in patients without thromboembolism (3.8 ± 0.9 vs 2.8 ± 0.7 mm, p <0.001). One hundred fifty-five patients (89%) underwent real-time 3D TEE during follow-up. There were no thrombi in 39 patients (25%); 45 (29%) had regression of thrombi, and there was no change in thrombus size in 68 patients (44%). Thrombus size increased in 3 patients (2%). Thrombosis was confirmed surgically and histopathologically in 12 patients (7%). In conclusion, real-time 3D TEE can detect prosthetic mitral ring thrombosis that could be missed on 2D TEE and cause thromboembolic events. Copyright © 2013 Elsevier Inc. All rights reserved.

Real-Time Dynamic Modeling - Data Information Requirements and Flight Test Results

NASA Technical Reports Server (NTRS)

Morelli, Eugene A.; Smith, Mark S.

2008-01-01

Practical aspects of identifying dynamic models for aircraft in real time were studied. Topics include formulation of an equation-error method in the frequency domain to estimate non-dimensional stability and control derivatives in real time, data information content for accurate modeling results, and data information management techniques such as data forgetting, incorporating prior information, and optimized excitation. Real-time dynamic modeling was applied to simulation data and flight test data from a modified F-15B fighter aircraft, and to operational flight data from a subscale jet transport aircraft. Estimated parameter standard errors and comparisons with results from a batch output-error method in the time domain were used to demonstrate the accuracy of the identified real-time models.

Real-Time Dynamic Modeling - Data Information Requirements and Flight Test Results

NASA Technical Reports Server (NTRS)

Morelli, Eugene A.; Smith, Mark S.

2010-01-01

Practical aspects of identifying dynamic models for aircraft in real time were studied. Topics include formulation of an equation-error method in the frequency domain to estimate non-dimensional stability and control derivatives in real time, data information content for accurate modeling results, and data information management techniques such as data forgetting, incorporating prior information, and optimized excitation. Real-time dynamic modeling was applied to simulation data and flight test data from a modified F-15B fighter aircraft, and to operational flight data from a subscale jet transport aircraft. Estimated parameter standard errors, prediction cases, and comparisons with results from a batch output-error method in the time domain were used to demonstrate the accuracy of the identified real-time models.

A home monitoring program including real-time wireless home spirometry in idiopathic pulmonary fibrosis: a pilot study on experiences and barriers.

PubMed

Moor, C C; Wapenaar, M; Miedema, J R; Geelhoed, J J M; Chandoesing, P P; Wijsenbeek, M S

2018-05-29

In idiopathic pulmonary fibrosis (IPF), home monitoring experiences are limited, not yet real-time available nor implemented in daily care. We evaluated feasibility and potential barriers of a new home monitoring program with real-time wireless home spirometry in IPF. Ten patients with IPF were asked to test this home monitoring program, including daily home spirometry, for four weeks. Measurements of home and hospital spirometry showed good agreement. All patients considered real-time wireless spirometry useful and highly feasible. Both patients and researchers suggested relatively easy solutions for the identified potential barriers regarding real-time home monitoring in IPF.

Hypersonic Research Vehicle (HRV) real-time flight test support feasibility and requirements study. Part 1: Real-time flight experiment support

NASA Technical Reports Server (NTRS)

Rediess, Herman A.; Ramnath, Rudrapatna V.; Vrable, Daniel L.; Hirvo, David H.; Mcmillen, Lowell D.; Osofsky, Irving B.

1991-01-01

The results are presented of a study to identify potential real time remote computational applications to support monitoring HRV flight test experiments along with definitions of preliminary requirements. A major expansion of the support capability available at Ames-Dryden was considered. The focus is on the use of extensive computation and data bases together with real time flight data to generate and present high level information to those monitoring the flight. Six examples were considered: (1) boundary layer transition location; (2) shock wave position estimation; (3) performance estimation; (4) surface temperature estimation; (5) critical structural stress estimation; and (6) stability estimation.

Non-Optical Applications of Photonic Crystal Structures

DTIC Science & Technology

2005-02-23

antenna created by covering a metallic ground plane with a periodic band-gap structure. By incorporating varactor diodes into the structure, they have...defects can be created in alumina band-gap materials by use of laser machining. (a) 1ncalizcd A 1II Cavity Fig 10 - (a) Schematics of propagation of...The primary applications are in dentistry and dermatology . The scale length of Terahertz devices simplifies the problems of fabrication and

Human Neck Response during Vertical Impact with Variable Weighted Helmets

DTIC Science & Technology

2006-09-01

activated, action potentials from the brain travel to motor neurons which branch out to the muscle fibers . EMG sensors record the action potentials of...the motor unit, comprised of several activated muscle fibers . An "EMG signal directly reflects the recruitment and firing characteristics of the...upper trapezius and SCM associated with isometric muscle contractions. They thoroughly investigated the mechanics of muscle fatigue during helmet loading

Economic Sanctions and Zimbabwe

DTIC Science & Technology

2010-03-01

succeed ? The answer is that it depends on the objective(s) of the imposing states, the polity and economy of the target country and the individual(s) of...the country who are making policy decisions. Consequently, economic sanctions can succeed or fail miserably based on the context of their use...political behavior by the target state or individual actors within that state for the purpose of compliance with internationally agreed upon norms

Post-Irradiation Polymerization of a Silorane Composite

DTIC Science & Technology

2013-04-26

methacrylate-based two- step self-etching adhesive system that is necessary to bond the silorane to tooth 3 structure. The dentin bond strength of...the Filtek LS system is equivalent to that of methacrylate-based systems if the Filtek LS primer and adhesive are used. However, siloranes are not...Maj Bryan Wilson 2. Academic Title: Resident, Advanced Education in General· Dentistry Residency (AEGD-2) 3. School/Department/Center: Air Force

Optimal Semi-Adaptive Search With False Targets

DTIC Science & Technology

2017-12-01

we do not execute a full experimental design to attempt to build a response surface for the performance of these model under various combinations of...the degree of MASTER OF SCIENCE IN OPERATIONS RESEARCH from the NAVAL POSTGRADUATE SCHOOL December 2017 Approved by: Johannes O. Royset, Ph.D. Thesis...Advisor Dashi I. Singham, Ph.D. Second Reader Patricia A. Jacobs, Ph.D. Chair, Department of Operations Research iii THIS PAGE INTENTIONALLY LEFT

What makes a place special? Interpretation of written survey responses in natural resource planning

Treesearch

Herbert W. Schroeder

2000-01-01

In an open-ended, written survey, I asked residents and visitors of the Black River area in northern Michigan to identify and describe places that were special to them. I conducted a thematic interpretation of the responses, using a set of indexing and cross-referencing marcos that I wrote in Word Perfect 5.1. The themes that emerged included the natural beauty ofthe...

Mechanical Characterization of Anion Exchange Membranes Under Controlled Environmental Conditions

DTIC Science & Technology

2015-05-11

are a common mechanical failure in fuel cell membranes, and elongation at break correlates well with microcrack resistance [29]. In an effort to...TestEquity sample chamber controlled temperature and humidity during data acquisition. Membrane resistance was defined as the low frequency intercept of...the Nyquist impedance plot and conductivity, σ, was calculated using the film dimensions where R is the membrane resistance , l 26 is the length

Japan-U.S. Relations: Issues for Congress

DTIC Science & Technology

2013-02-15

million Japanese were displaced. Damage to several reactors at the Fukushima Dai-ichi nuclear power plant complex led the government to declare a state of...the March 11, 2011, natural disasters and meltdowns at the Fukushima Daiichi nuclear power plant. Public trust in the safety of nuclear power...aircraft’s safety record may be connected to widespread distrust of the government stemming from the nuclear disaster at the Fukushima Daichi

Hydrodynamic Forces on Spillway Torque-Tube Gates

DTIC Science & Technology

2010-10-01

damping coefficient associated with that of an equivalent viscous damper representing the energy dissipation mechanism from the structure itself plus the...in the figure the viscous damper with coef- ficient CD that exerts the drag force on the gate. The degree of freedom is defined as the rotation of...the following simplifying as- sumptions are postulated. Water is assumed an incompressible, inviscid, and homogeneous fluid , and its flow is taken as

Status Survey of Bunkers 738A and 825A at Spangdahlem AB, Germany

DTIC Science & Technology

2015-10-02

Germany 1. EXECUTIVE SUMMARY: At the request ofthe United States Air Force Radioisotope Committee Secretariat, the United States Air Force School of...solely for the purpose of the person to whom it is addressed. If received in error, please notify the Program Manager listed above. 34 Distribution...45433 - (937) 938-2523 Radiation Qualifier List Radioanalytical Services Laboratory Qualifier Qualifier Description A Identification Rejected B (ELAP

Sub-Saharan Africa Report

DTIC Science & Technology

1987-01-26

cashew nuts in some of its districts. They are the districts of Mandlhakaze and Chibuto, where one can already observe the cashews on the cashew nut ...reached the province. For example, in Manjacaze district, the marketing of cashew nuts has already started at the headquarters in the locality of...the previous one. The locality of Chimbonhanine is considered the cashew nut production and market- ing center for the district of Chibuto. In fact

Chemoprevention of Prostate Cancer by Phenethyl Isothiocyanate

DTIC Science & Technology

2007-03-01

AD cells were exposed to PEITC, protein synthesis inhibitor cycloheximide (CHX), or proteasome inhibitor MG-132 alone, or to the combination of...The results indicated that down-regulation of Sp1 may require protein synthesis for a proteasome activity, thereby enhancing Sp1 protein degradation...carcinogen N- methyl-N- nitrosourea (MNU) for the formation of prostate tumors. The experimental group of rats was provided with PEITC, to evaluate the

A Checklist of Common Plants of the Appalachian Trial in the Nantahala National Forest, North Carolina

Treesearch

Arnold Krochmal; Connie Krochmal

1980-01-01

This Note lists the plants that a hiker is likely to notice on the Appalachian Trail in the Nantahala Forest, North Carolina. The list is one ofthe results of an inventory of plant life along the Trail as it passes through Southern National Forests. Only plants that were conspicuous because of their size, large population, or leaf or flower color are listed. Fungi,...

Oceanographic and Acoustical Survey of the East Ionian Sea

DTIC Science & Technology

1990-09-01

Notation The views expressed-in this thesis are those of the author and do not reflect the official policy or po- sition -of-the Department of Defense...8217 ,_ ,=--- . OLo • :. LU _ -09 5 /- S US8 0)6 0 • OU G I:: -CD *.. LU Uz CD_ _ _ Li C) . LU M -- cN C.8 C C - ------- CD CnCD C:) C81 m 0- ’an 0 0

National Security Personnel System (NSPS) - 2008 Evaluation Report

DTIC Science & Technology

2009-05-15

full rating cycle and fITSt full year of operation for most ofthe Spiral I workforce. The report is intended to show where NSPS stood at the end of...for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware that...the 2008 rmdings reflect an early stage of implementation, it remains essential that organizations operating under NSPS continue to focus on

Kuroshio Transport East of Taiwan and the Effect of Mesoscale Eddies

DTIC Science & Technology

2015-09-30

1 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. Kuroshio Transport East of Taiwan and the Effect of...The objective of this project is to characterize variability in the Kuroshio east of Taiwan and to understand (1) how this variability is related to...Mindanao Current and (2) how westward-propagating mesoscale eddies that arrive east of Taiwan from the ocean interior affect Kuroshio variability. This

Inhibition of Estrogen-induced Growth of Breast Cancer by Targeting Mitochondrial Oxidants

DTIC Science & Technology

2009-04-01

chemical antioxidants, [N- acetylcysteine (NAC) and ebselen], inhibits estrogen induced expression of cell cycle genes as well as prevention of...the original First Task (i) both antioxidants, N- acetylcysteine and ebselen, overexpression of ROS lowering genes, such as, catalase or PrxIII; and... acetylcysteine and ebselen; overexpression of MnSOD, catalase, PrxIII, Trx2, or mtTFA silencing. Major findings are described in detail below: 1

Klystron Manufacturing Technology Program.

DTIC Science & Technology

1983-09-01

processes, and methodology used on the current production tube, VKU-7735E, and the new methods and techniques used to improve and reduce the cost of...the bellows. This alignment is c~tclto the smoothi operation of the internal tuniing mezhanism. IT METR𔃼D - VKCU-7795F The new assembly method changes...Varian, the MT contractor that the new methodology , technologies and process changes introduced into the MT power klystron and autotuner assembly - VKU

Research Laboratory of Electronics Progress Report Number 133

DTIC Science & Technology

1991-08-01

Anatomical Basis for the Relationships Between Binaural Hearing and Brainstem Auditory Evoked Potentials in Humans...frequencyjitter by simply beating the outputs of two Brillouin lasers that share the same cavity, we Figure 1. Brillouin laser output. found the width of...the beat to be limited by the 30 Hz instrumental linewidth of our spectrum ana- Figure 1 shows the pump propagating in a fiber lyzer.7 ring resonator

[CHEMICAL AIR POLLUTION OF THE OCCUPATIONAL ENVIRONMENT AS A FACTOR FOR PROFESSIONAL RISK FOR WORKERS OF MAIN OCCUPATIONS IN THE COPPER AND NICKEL METALLURGY].

PubMed

Lipatov, G Ia; Adrianovskiĭ, V I; Gogoleva, O I

2015-01-01

There are presented the results of hygienic researches of the harmful substances content in the air of the working area ofthe copper and nickel metallurgy. Sulfur-containing gases (primarily sulfur dioxide), to the effects of which there are exposed workers of drying, smelting, converter conversion, are shown to play a leading role among professional factors.

Life and Damage Monitoring-Using NDI Data Interpretation for Corrosion Damage and Remaining Life Assessments

DTIC Science & Technology

2003-02-01

Holistic Life Prediction Methodology Engineering is a profession based in science, but in the face of limited data or resources, the application of...the process. (see Table 1). "* HLPM uses continuum mechanics but defines limits of applicability - is material and process specific. "* HLPM defines...LEFM - EPFM ?) Nucleated Structure dominated Data base** Tensile/compressive discontinuity (not crack growth buckling inherent) type, size, Appropriate

Cloud-Based Perception and Control of Sensor Nets and Robot Swarms

DTIC Science & Technology

2016-04-01

distributed stream processing framework provides the necessary API and infrastructure to develop and execute such applications in a cluster of computation...streaming DDDAS applications based on challenges they present to the backend Cloud control system. Figure 2 Parallel SLAM Application 3 1) Set of...the art deep learning- based object detectors can recognize among hundreds of object classes and this capability would be very useful for mobile

Chile, 1964-74: The Successes and Failures of Reformism

DTIC Science & Technology

1975-09-22

upon mining for a majur portion or government revenue, saddled with an agricultural system characterized by the inequities and inefficiencies of...the most votes Allende and Alessandri. The Alessandri forces , in a gambit to upset traditional practice and invalidate the election, attempted a...and Alknde’s contradictory "peaceful transition to socialism" bring the country to the brink of civil war, the Armed Forces decided to dispense with

The Use of Computers as a Design Tool.

DTIC Science & Technology

1980-01-01

design programs for the technical management of complex fighter development projects. AIAA Paper No. 70-364, March 1970 22. J. Kondo: Application of...the scope and effectiveness of their use are sometimes considered suspect, especially by managers and decision makers who must depend, to some...uncertainty and the fact that the measured and calculated data cannot be easily combined often leave the project manager or designer SPIRAL PORTION

Annual Science and Engineering Technology Conference/DOD Technology Exposition (7th). Volume 2. Wednesday - Thursday

DTIC Science & Technology

2006-04-20

Disruptive Technologies • Army Approach to Disruptive Technologies and Transition Mr. Dennis Schmidt, Director, Science & Technology Integration, Office of...the Assistant Secretary of the Army for Research and Technology • Navy Approach to Disruptive Technologies and Transition Mr. Lewis DeSandre, Program...Manager, ONR 351 • Air Force Approach to Disruptive Technologies and Transition Colonel Mark Stephen, Associate Deputy Assistant Secretary (Science

7th Annual Science and Engineering Technology Conference/DoD Technology Exposition Volume 1

DTIC Science & Technology

2006-04-20

Disruptive Technologies • Army Approach to Disruptive Technologies and Transition Mr. Dennis Schmidt, Director, Science & Technology Integration, Office of...the Assistant Secretary of the Army for Research and Technology • Navy Approach to Disruptive Technologies and Transition Mr. Lewis DeSandre, Program...Manager, ONR 351 • Air Force Approach to Disruptive Technologies and Transition Colonel Mark Stephen, Associate Deputy Assistant Secretary (Science

Pharmacy on Demand Feasibility Assessment

DTIC Science & Technology

2008-07-19

We have successfully carried out the first two steps of the ibuprofen synthesis in our microreactor using homogeneous reactions in a continuous...Average of two trials. c Average of three trials. d Using a 0.25 M stock solution of isobutylbenzene. e Using a 0.5 M stock solution of...the creation of a packed-bed microreactor is the preparation of the solid-supported reagent. We have previously demonstrated that the performance

Advanced Concepts Theory Annual Report 1989

DTIC Science & Technology

1990-03-29

kinetic energy to x-ray conversion and are being evaluated using nickel array implosion calculations. iv o Maxwell Laboratory aluminum array implosion...general, we need to evaluate the degree of machine PRS decoupling produced by runaway electrons, and the existence of a corona may be a relevant aspect of...the tools necessary to carry out data analysis and interpretation and (4) promote the design and evaluation of new experiments and new improved loads

A Review of Regional Development Theory

DTIC Science & Technology

1989-03-20

Editorial Review by Lt Col James R. Aubrey Department of English USAF Academy, Colorado 80840 This research report is presented as a competent treatment of...the subject, worthy of publication. The United States Air Force Academy vouches for the quality of the research , without * necessarily endorsing the...to the National Technical Information Service. pTle This research report has been reviewed and is approved for publication. RICHARD DURHAM, Lt Col

Design of Polymers with Semiconductor, NLO and Structural Properties.

DTIC Science & Technology

1991-04-22

polymer thin films. + 14 KV Needle electrod Polymer layer ITO electrode Substrate Heater and temperature control unit The second harmonic coefficients of...the solubily and processability through utilization of derivitization and precursor routes we have been able to form the first optical quality films...ethylene spacer, and therefore 14 possesses a great degree of solubility in organic solvents, necessary for the fabrication of optical quality thin films

JPRS Report, East Europe.

DTIC Science & Technology

1988-10-26

traditional manner, again begin to increase. The supply of market goods increases some- what. Yet even earlier that was how output grew for some 40...To be sure, there is a temporary increase in the supply of market goods , but the market imbalance is growing and inflation is rising. What kind of...the allocation of basic pro- ducer goods ; fixes output targets under the appellation of operational plans and government orders; organizes market

Recent geologic history of lake Atitlán, a caldera lake in western Guatemala

USGS Publications Warehouse

Newhall, C.G.; Paull, C.K.; Bradbury, J.P.; Higuera-Gundy, A.; Poppe, L.J.; Self, S.; Bonar, Sharpless N.; Ziagos, J.

1987-01-01

Heat-flow measurements inside and just outside the caldera are high (290 and 230 mW m−2), suggesting hydrothermal convection and a shallow heat source. High heat flow, a geological record of post-caldera silicic eruptions, and unexplained fluctuations of lake level (episodic tumescence ofthe lake floor?) suggest that magma remains beneath Lake Atitlán and that future eruptions are possible.

Terrain Aided Navigation for Remus Autonomous Underwater Vehicle

DTIC Science & Technology

2014-06-01

22  Figure 11.  Several successive sonar pings displayed together in the LTP frame .............23  Figure 12.  The linear interpolation of...the sonar pings from Figure 11 .............................24  Figure 13.  SIR particle filter algorithm, after [19... ping —  |p k ky x .........46  Figure 26.  Correlation probability distributions for four different sonar images ..............47  Figure 27.  Particle

Military and Security Developments Involving the People’s Republic of China 2013

DTIC Science & Technology

2013-01-01

discussions have stalled over pricing differences. China’s Top Crude Suppliers 2011 Country Volume (1,000 barrels per day) Percentage of...the transfer or disclosure of U.S.-origin defense articles, defense services, technical data, and/or technology to China. Additionally, Public Law... transfer or export of defense articles (including technical data) and defense services. Beijing primarily conducts arms sales to enhance foreign

Defects Associated with Soldification of Melt Processed Superalloys for the Aerospace Industry

DTIC Science & Technology

2008-07-23

resulting computational model will be in a form that is usable in their efforts to design new alloys and processing routes. Given the broad research...thermodynamics modeling by Asta and Woodward. The permeability of dendritic arrays in superalloys has been determined using three-dimensional reconstructions of...the solid-liquid mush and finite-element fluid simulations by Pollock and Spowart. Close interaction with industry ensured that computational

Bioaugmentation for Groundwater Remediation

DTIC Science & Technology

2010-02-01

continually grown and harvested , in fed batch mode where a culture is grown in a vessel and harvested and then another culture begun, or in a hybrid of...the two whereby the culture is maintained in a fermentor until a volume of culture is harvested and then replaced with fresh medium. The primary...producing cultures for bioaugmentation is a semi- continuous process whereby the culture is maintained in the fermentor until needed and then harvested

The Use of Fuzzy Set Classification for Pattern Recognition of the Polygraph

DTIC Science & Technology

1993-12-01

actual feature extraction was done, It was decided to use the K-nearest neighbor ( KNN ) the data was preprocessed. The electrocardiogram classifier in...showing heart pulse, and a low frequency not known beforehand, and the KNN classifier does not component showing blood volume. The derivative of...the characteristics of the conventional KNN these six derived signals were detrended and filtered, classification method is that it assigns each

Multiplex Real-Time PCR Method for Simultaneous Identification and Toxigenic Type Characterization of Clostridium difficile From Stool Samples

PubMed Central

Alam, Mohammad J.; Tisdel, Naradah L.; Shah, Dhara N.; Yapar, Mehmet; Lasco, Todd M.; Garey, Kevin W.

2015-01-01

Background The aim of this study was to develop and validate a multiplex real-time PCR assay for simultaneous identification and toxigenic type characterization of Clostridium difficile. Methods The multiplex real-time PCR assay targeted and simultaneously detected triose phosphate isomerase (tpi) and binary toxin (cdtA) genes, and toxin A (tcdA) and B (tcdB) genes in the first and sec tubes, respectively. The results of multiplex real-time PCR were compared to those of the BD GeneOhm Cdiff assay, targeting the tcdB gene alone. The toxigenic culture was used as the reference, where toxin genes were detected by multiplex real-time PCR. Results A total of 351 stool samples from consecutive patients were included in the study. Fifty-five stool samples (15.6%) were determined to be positive for the presence of C. difficile by using multiplex real-time PCR. Of these, 48 (87.2%) were toxigenic (46 tcdA and tcdB-positive, two positive for only tcdB) and 11 (22.9%) were cdtA-positive. The sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) of the multiplex real-time PCR compared with the toxigenic culture were 95.6%, 98.6%, 91.6%, and 99.3%, respectively. The analytical sensitivity of the multiplex real-time PCR assay was determined to be 103colonyforming unit (CFU)/g spiked stool sample and 0.0625 pg genomic DNA from culture. Analytical specificity determined by using 15 enteric and non-clostridial reference strains was 100%. Conclusions The multiplex real-time PCR assay accurately detected C. difficile isolates from diarrheal stool samples and characterized its toxin genes in a single PCR run. PMID:25932438

Verifying Hybrid Systems Modeled as Timed Automata: A Case Study

DTIC Science & Technology

1997-03-01

Introduction Researchers have proposed many innovative formal methods for developing real - time systems [9]. Such methods can give system developers and...customers greater con dence that real - time systems satisfy their requirements, especially their crit- ical requirements. However, applying formal methods...specifying and reasoning about real - time systems that is designed to address these challenging problems. Our approach is to build formal reasoning tools

Explaining How to Play Real-Time Strategy Games

NASA Astrophysics Data System (ADS)

Metoyer, Ronald; Stumpf, Simone; Neumann, Christoph; Dodge, Jonathan; Cao, Jill; Schnabel, Aaron

Real-time strategy games share many aspects with real situations in domains such as battle planning, air traffic control, and emergency response team management which makes them appealing test-beds for Artificial Intelligence (AI) and machine learning. End user annotations could help to provide supplemental information for learning algorithms, especially when training data is sparse. This paper presents a formative study to uncover how experienced users explain game play in real-time strategy games. We report the results of our analysis of explanations and discuss their characteristics that could support the design of systems for use by experienced real-time strategy game users in specifying or annotating strategy-oriented behavior.

Real-time Fatigue and Free-Living Physical Activity in Hematopoietic Stem Cell Transplantation Cancer Survivors and Healthy Controls: A Preliminary Examination of the Temporal, Dynamic Relationship.

PubMed

Hacker, Eileen Danaher; Kim, Inah; Park, Chang; Peters, Tara

Fatigue and physical inactivity, critical problems facing cancer survivors, impact overall health and functioning. Our group designed a novel methodology to evaluate the temporal, dynamic patterns in real-world settings. Using real-time technology, the temporal, dynamic relationship between real-time fatigue and free-living is described and compared in cancer survivors who were treated with hematopoietic stem cell transplantation (n = 25) and age- and gender-matched healthy controls (n = 25). Subjects wore wrist actigraphs on their nondominant hand to assess free-living physical activity, measured in 1-minute epochs, over 7 days. Subjects entered real-time fatigue assessments directly into the subjective event marker of the actigraph 5 times per day. Running averages of mean 1-minute activity counts 30, 60, and 120 minutes before and after each real-time fatigue score were correlated with real-time fatigue using generalized estimating equations, RESULTS:: A strong inverse relationship exists between real-time fatigue and subsequent free-living physical activity. This inverse relationship suggests that increasing real-time fatigue limits subsequent physical activity (B range= -0.002 to -0.004; P < .001). No significant differences in the dynamic patterns of real-time fatigue and free-living physical activity were found between groups. To our knowledge, this is the first study to document the temporal and potentially causal relationship between real-time fatigue and free-living physical activity in real-world setting. These findings suggest that fatigue drives the subsequent physical activity and the relationship may not be bidirectional. Understanding the temporal, dynamic relationship may have important health implications for developing interventions to address fatigue in cancer survivors.

An OPTIMIZE study retrospective analysis for management of telaprevir-treated hepatitis C virus (HCV)-infected patients by use of the Abbott RealTime HCV RNA assay.

PubMed

Sarrazin, Christoph; Dierynck, Inge; Cloherty, Gavin; Ghys, Anne; Janssen, Katrien; Luo, Donghan; Witek, James; Buti, Maria; Picchio, Gaston; De Meyer, Sandra

2015-04-01

Protease inhibitor (PI)-based response-guided triple therapies for hepatitis C virus (HCV) infection are still widely used. Noncirrhotic treatment-naive and prior relapser patients receiving telaprevir-based treatment are eligible for shorter, 24-week total therapy if HCV RNA is undetectable at both weeks 4 and 12. In this study, the concordance in HCV RNA assessments between the Roche High Pure System/Cobas TaqMan and Abbott RealTime HCV RNA assays and the impacts of different HCV RNA cutoffs on treatment outcome were evaluated. A total of 2,629 samples from 663 HCV genotype 1 patients receiving telaprevir/pegylated interferon/ribavirin in OPTIMIZE were analyzed using the High Pure System and reanalyzed using Abbott RealTime (limits of detection, 15.1 IU/ml versus 8.3 IU/ml; limits of quantification, 25 IU/ml versus 12 IU/ml, respectively). Overall, good concordance was observed between the assays. Using undetectable HCV RNA at week 4, 34% of the patients would be eligible for shorter treatment duration with Abbott RealTime versus 72% with the High Pure System. However, using <12 IU/ml for Abbott RealTime, a similar proportion (74%) would be eligible. Of the patients receiving 24-week total therapy, 87% achieved a sustained virologic response with undetectable HCV RNA by the High Pure System or <12 IU/ml by Abbott RealTime; however, 92% of the patients with undetectable HCV RNA by Abbott RealTime achieved a sustained virologic response. Using undetectable HCV RNA as the cutoff, the more sensitive Abbott RealTime assay would identify fewer patients eligible for shorter treatment than the High Pure System. Our data confirm the <12-IU/ml cutoff, as previously established in other studies of the Abbott RealTime assay, to determine eligibility for shortened PI-based HCV treatment. (The study was registered with ClinicalTrials.gov under registration no. NCT01241760.). Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Detection of mRNA by reverse transcription PCR as an indicator of viability in Phytophthora ramorum

Treesearch

Antonio Chimento; Santa Olga Cacciola; Matteo Garbelotto

2008-01-01

Real-Time PCR technologies offer increasing opportunities to detect and study phytopathogenic fungi. They combine the sensitivity of conventional PCR with the generation of a specific fluorescent signal providing both real-time analysis of the reaction kinetics and quantification of specific DNA targets. Before the development of Real-Time PCR and...

Reducing lumber thickness variation using real-time statistical process control

Treesearch

Thomas M. Young; Brian H. Bond; Jan Wiedenbeck

2002-01-01

A technology feasibility study for reducing lumber thickness variation was conducted from April 2001 until March 2002 at two sawmills located in the southern U.S. A real-time statistical process control (SPC) system was developed that featured Wonderware human machine interface technology (HMI) with distributed real-time control charts for all sawing centers and...

Effects of Real-Time Visual Feedback on Pre-Service Teachers' Singing

ERIC Educational Resources Information Center

Leong, S.; Cheng, L.

2014-01-01

This pilot study focuses on the use real-time visual feedback technology (VFT) in vocal training. The empirical research has two aims: to ascertain the effectiveness of the real-time visual feedback software "Sing & See" in the vocal training of pre-service music teachers and the teachers' perspective on their experience with…

A new diagnostic real-time PCR method for huanglongbing detection in citrus root tissue

USDA-ARS?s Scientific Manuscript database

Citrus fibrous root tissue was evaluated as an alternative source material for Huanglongbing (HLB) diagnosis by real-time PCR using primer-probe set TXCChlb, developed in the present study based on 16S rDNA of “Candidatus Liberibacter asiaticus” (CLas). Real-time PCR data obtained with DNA samples p...

Agent-based real-time signal coordination in congested networks.

DOT National Transportation Integrated Search

2014-01-01

This study is the continuation of a previous NEXTRANS study on agent-based reinforcement : learning methods for signal coordination in congested networks. In the previous study, the : formulation of a real-time agent-based traffic signal control in o...

Single tube multiplex real-time PCR for the rapid detection of herpesvirus infections of the central nervous system.

PubMed

Sankuntaw, Nipaporn; Sukprasert, Saovaluk; Engchanil, Chulapan; Kaewkes, Wanlop; Chantratita, Wasun; Pairoj, Vantanit; Lulitanond, Viraphong

2011-01-01

Human herpesvirus infection of immunocompromised hosts may lead to central nervous system (CNS) infection and diseases. In this study, a single tube multiplex real-time PCR was developed for the detection of five herpesviruses (HSV-1, HSV-2, VZV, EBV and CMV) in clinical cerebrospinal fluid (CSF) specimens. Two primer pairs specific for the herpesvirus polymerase gene and five hybridization probe pairs for the specific identification of the herpesvirus types were used in a LightCycler multiplex real-time PCR. A singleplex real-time PCR was first optimized and then applied to the multiplex real-time PCR. The singleplex and multiplex real-time PCRs showed no cross-reactivity. The sensitivity of the singleplex real-time PCR was 1 copy per reaction for each herpesvirus, while that of the multiplex real-time PCR was 1 copy per reaction for HSV-1 and VZV and 10 copies per reaction for HSV-2, EBV and CMV. Intra and inter-assay variations of the single tube multiplex assay were in the range of 0.02%-3.67% and 0.79%-4.35%, respectively. The assay was evaluated by testing 62 clinical CSF samples and was found to have equivalent sensitivity, specificity and agreement as the routine real-time PCR, but reducing time, cost and amount of used sample. Copyright © 2011 Elsevier Ltd. All rights reserved.

[Primary emergencies: management of acute ischemic stroke].

PubMed

Leys, Didier; Goldstein, Patrick

2012-01-01

The emergency diagnostic strategy for acute ischemic stroke consists of:--identification of stroke, based on clinical examination (sudden onset of a focal neurological deficit);--identification of the ischemic or hemorrhagic nature by MRI or CT;--determination of the early time-course (clinical examination) and the cause. In all strokes (ischemic or hemorrhagic), treatment consists of:--the same general management (treatment of a life-threatening emergency, ensuring normal biological parameters except for blood pressure, and prevention of complications);--decompressive surgery in the rare cases of intracranial hypertension. For proven ischemic stroke, other therapies consist of: rt-PA for patients admitted with 4.5 hours of stroke onset who have no contraindications, and aspirin (160 to 300 mg) for patients who are not eligible for rt-PA. These treatments should be administered within a few hours. A centralized emergency call system (phone number 15 in France) is the most effective way of achieving this objective.

Feasibility study: real-time 3-D ultrasound imaging of the brain.

PubMed

Smith, Stephen W; Chu, Kengyeh; Idriss, Salim F; Ivancevich, Nikolas M; Light, Edward D; Wolf, Patrick D

2004-10-01

We tested the feasibility of real-time, 3-D ultrasound (US) imaging in the brain. The 3-D scanner uses a matrix phased-array transducer of 512 transmit channels and 256 receive channels operating at 2.5 MHz with a 15-mm diameter footprint. The real-time system scans a 65 degrees pyramid, producing up to 30 volumetric scans per second, and features up to five image planes as well as 3-D rendering, 3-D pulsed-wave and color Doppler. In a human subject, the real-time 3-D scans produced simultaneous transcranial horizontal (axial), coronal and sagittal image planes and real-time volume-rendered images of the gross anatomy of the brain. In a transcranial sheep model, we obtained real-time 3-D color flow Doppler scans and perfusion images using bolus injection of contrast agents into the internal carotid artery.

Real-time quasi-3D tomographic reconstruction

NASA Astrophysics Data System (ADS)

Buurlage, Jan-Willem; Kohr, Holger; Palenstijn, Willem Jan; Joost Batenburg, K.

2018-06-01

Developments in acquisition technology and a growing need for time-resolved experiments pose great computational challenges in tomography. In addition, access to reconstructions in real time is a highly demanded feature but has so far been out of reach. We show that by exploiting the mathematical properties of filtered backprojection-type methods, having access to real-time reconstructions of arbitrarily oriented slices becomes feasible. Furthermore, we present , software for visualization and on-demand reconstruction of slices. A user of can interactively shift and rotate slices in a GUI, while the software updates the slice in real time. For certain use cases, the possibility to study arbitrarily oriented slices in real time directly from the measured data provides sufficient visual and quantitative insight. Two such applications are discussed in this article.

Techniques for efficient, real-time, 3D visualization of multi-modality cardiac data using consumer graphics hardware.

PubMed

Levin, David; Aladl, Usaf; Germano, Guido; Slomka, Piotr

2005-09-01

We exploit consumer graphics hardware to perform real-time processing and visualization of high-resolution, 4D cardiac data. We have implemented real-time, realistic volume rendering, interactive 4D motion segmentation of cardiac data, visualization of multi-modality cardiac data and 3D display of multiple series cardiac MRI. We show that an ATI Radeon 9700 Pro can render a 512x512x128 cardiac Computed Tomography (CT) study at 0.9 to 60 frames per second (fps) depending on rendering parameters and that 4D motion based segmentation can be performed in real-time. We conclude that real-time rendering and processing of cardiac data can be implemented on consumer graphics cards.

Violent Relaxation, Dynamical Instabilities and the Formation of Elliptical Galaxies

NASA Astrophysics Data System (ADS)

Aguilar, L. A.

1990-11-01

RESUMEN: El problema de la formaci6n de galaxias elfpticas por medjo de colapso gravitacional sin disipaci6n de energfa es estudiado usando un gran numero de simulaciones numericas. Se muestra que este tipo de colapsos, partiendo de condiciones iniciales frfas donde la energfa cinetica inicial representa s6lo un 5%, 0 , de a potencial inicial, produce sistemas relajados de forma triaxial muy similares a las galaxias elfpticas reales en sus formas y perfiles de densidad en proyecci6i . La forina triaxial resulta de la acci6n de una inestabilidad dinamica que aparece en sistemas 'inicos dominados por movimientos radiales, mientras que el perfil de densidad final Cs debido al llamado relajamiento violento que tiende a producir una distribuci6n en espacio fase unica. Estos dos fen6menos tienden a borrar los detalles particulares sobre las condiciones iniciales y dan lugar a una evoluci6n convergente hacia sistemas realistas, esto innecesario el uso de condiciones iniciales especiales (excepto por Ia condici6i de que estas deben ser frfas). Las condiciones iniciales frfas producen los movimientos radiales y fluctuaciones de la energfa potencial requeridos por ambos fen6menos. ABSTRACT: The problem of formation of elliptical galaxies via dissipationless collapse is studied using a large set of numerical simulations. It is shown that dissipationless collapses from cold initial conditions, where the total initial kinetic energy is less than 5% ofthe initial potential energy, lead to relaxed triaxial systems ery similar to real elliptical galaxies ii projected shape and density profiles. The triaxial shape is due to the of a dynamical instability that appears on systems dominated by radial orbits, while final density profile is due to violent relaxation that tends to produce a unique distribution iii space. These two phenomena erase memory of the initial prodtice a convergent evolution toward realistic systems, thus making unnecessary use o[special initial conditions (other than the condition ofbeing cold). Cold initial the radial orbits and large potential energy fluctuations necessary for both and are thus sufficient. KQ words: GALAXIES-DYNAMICS - GALAXIES-ELLIPTICAL - GALAXIES-FORMATION

[Design and implementation of real-time continuous glucose monitoring instrument].

PubMed

Huang, Yonghong; Liu, Hongying; Tian, Senfu; Jia, Ziru; Wang, Zi; Pi, Xitian

2017-12-01

Real-time continuous glucose monitoring can help diabetics to control blood sugar levels within the normal range. However, in the process of practical monitoring, the output of real-time continuous glucose monitoring system is susceptible to glucose sensor and environment noise, which will influence the measurement accuracy of the system. Aiming at this problem, a dual-calibration algorithm for the moving-window double-layer filtering algorithm combined with real-time self-compensation calibration algorithm is proposed in this paper, which can realize the signal drift compensation for current data. And a real-time continuous glucose monitoring instrument based on this study was designed. This real-time continuous glucose monitoring instrument consisted of an adjustable excitation voltage module, a current-voltage converter module, a microprocessor and a wireless transceiver module. For portability, the size of the device was only 40 mm × 30 mm × 5 mm and its weight was only 30 g. In addition, a communication command code algorithm was designed to ensure the security and integrity of data transmission in this study. Results of experiments in vitro showed that current detection of the device worked effectively. A 5-hour monitoring of blood glucose level in vivo showed that the device could continuously monitor blood glucose in real time. The relative error of monitoring results of the designed device ranged from 2.22% to 7.17% when comparing to a portable blood meter.

Development of an on-site rapid real-time polymerase chain reaction system and the characterization of suitable DNA polymerases for TaqMan probe technology.

PubMed

Furutani, Shunsuke; Naruishi, Nahoko; Hagihara, Yoshihisa; Nagai, Hidenori

2016-08-01

On-site quantitative analyses of microorganisms (including viruses) by the polymerase chain reaction (PCR) system are significantly influencing medical and biological research. We have developed a remarkably rapid and portable real-time PCR system that is based on microfluidic approaches. Real-time PCR using TaqMan probes consists of a complex reaction. Therefore, in a rapid real-time PCR, the optimum DNA polymerase must be estimated by using actual real-time PCR conditions. In this study, we compared the performance of three DNA polymerases in actual PCR conditions using our rapid real-time PCR system. Although KAPA2G Fast HS DNA Polymerase has the highest enzymatic activity among them, SpeedSTAR HS DNA Polymerase exhibited better performance to rapidly increase the fluorescence signal in an actual real-time PCR using TaqMan probes. Furthermore, we achieved rapid detection of Escherichia coli in 7 min by using SpeedSTAR HS DNA Polymerase with the same sensitivity as that of a conventional thermal cycler.

Detection of Listeria monocytogenes in ready-to-eat food by Step One real-time polymerase chain reaction.

PubMed

Pochop, Jaroslav; Kačániová, Miroslava; Hleba, Lukáš; Lopasovský, L'ubomír; Bobková, Alica; Zeleňáková, Lucia; Stričík, Michal

2012-01-01

The aim of this study was to follow contamination of ready-to-eat food with Listeria monocytogenes by using the Step One real time polymerase chain reaction (PCR). We used the PrepSEQ Rapid Spin Sample Preparation Kit for isolation of DNA and MicroSEQ® Listeria monocytogenes Detection Kit for the real-time PCR performance. In 30 samples of ready-to-eat milk and meat products without incubation we detected strains of Listeria monocytogenes in five samples (swabs). Internal positive control (IPC) was positive in all samples. Our results indicated that the real-time PCR assay developed in this study could sensitively detect Listeria monocytogenes in ready-to-eat food without incubation.

A study of workstation computational performance for real-time flight simulation

NASA Technical Reports Server (NTRS)

Maddalon, Jeffrey M.; Cleveland, Jeff I., II

1995-01-01

With recent advances in microprocessor technology, some have suggested that modern workstations provide enough computational power to properly operate a real-time simulation. This paper presents the results of a computational benchmark, based on actual real-time flight simulation code used at Langley Research Center, which was executed on various workstation-class machines. The benchmark was executed on different machines from several companies including: CONVEX Computer Corporation, Cray Research, Digital Equipment Corporation, Hewlett-Packard, Intel, International Business Machines, Silicon Graphics, and Sun Microsystems. The machines are compared by their execution speed, computational accuracy, and porting effort. The results of this study show that the raw computational power needed for real-time simulation is now offered by workstations.

Hardware in-the-Loop Demonstration of Real-Time Orbit Determination in High Earth Orbits

NASA Technical Reports Server (NTRS)

Moreau, Michael; Naasz, Bo; Leitner, Jesse; Carpenter, J. Russell; Gaylor, Dave

2005-01-01

This paper presents results from a study conducted at Goddard Space Flight Center (GSFC) to assess the real-time orbit determination accuracy of GPS-based navigation in a number of different high Earth orbital regimes. Measurements collected from a GPS receiver (connected to a GPS radio frequency (RF) signal simulator) were processed in a navigation filter in real-time, and resulting errors in the estimated states were assessed. For the most challenging orbit simulated, a 12 hour Molniya orbit with an apogee of approximately 39,000 km, mean total position and velocity errors were approximately 7 meters and 3 mm/s respectively. The study also makes direct comparisons between the results from the above hardware in-the-loop tests and results obtained by processing GPS measurements generated from software simulations. Care was taken to use the same models and assumptions in the generation of both the real-time and software simulated measurements, in order that the real-time data could be used to help validate the assumptions and models used in the software simulations. The study makes use of the unique capabilities of the Formation Flying Test Bed at GSFC, which provides a capability to interface with different GPS receivers and to produce real-time, filtered orbit solutions even when less than four satellites are visible. The result is a powerful tool for assessing onboard navigation performance in a wide range of orbital regimes, and a test-bed for developing software and procedures for use in real spacecraft applications.

76 FR 26787 - Short Sale Reporting Study Required by Dodd-Frank Act Section 417(a)(2)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-09

... benefits and costs be if this real time reporting information were to be made public on a delayed basis..., benefits, and costs be if this real time reporting information were to be made public on a delayed basis... feasibility, benefits, and costs of requiring reporting in real time, either publicly or, in the alternative...

A Review. A Real-Time Microcomputer-Assisted System for Translating Aural, Monophonic Tones into Music Notation as an Aid in Sight-Singing.

ERIC Educational Resources Information Center

Higgins, William R.

1987-01-01

Reviews a dissertation in which the problems of real-time pitch detection by computer were studied in an attempt to develop a learning tool for sightsinging students. Specialized hardware and software were developed to discriminate aural pitches and to display them in real-time using standard notation. (BSR)

Real-Time Tracking of Knee Adduction Moment in Patients with Knee Osteoarthritis

PubMed Central

Kang, Sang Hoon; Lee, Song Joo; Zhang, Li-Qun

2014-01-01

Background The external knee adduction moment (EKAM) is closely associated with the presence, progression, and severity of knee osteoarthritis (OA). However, there is a lack of convenient and practical method to estimate and track in real-time the EKAM of patients with knee OA for clinical evaluation and gait training, especially outside of gait laboratories. New Method A real-time EKAM estimation method was developed and applied to track and investigate the EKAM and other knee moments during stepping on an elliptical trainer in both healthy subjects and a patient with knee OA. Results Substantial changes were observed in the EKAM and other knee moments during stepping in the patient with knee OA. Comparison with Existing Method(s) This is the first study to develop and test feasibility of real-time tracking method of the EKAM on patients with knee OA using 3-D inverse dynamics. Conclusions The study provides us an accurate and practical method to evaluate in real-time the critical EKAM associated with knee OA, which is expected to help us to diagnose and evaluate patients with knee OA and provide the patients with real-time EKAM feedback rehabilitation training. PMID:24361759

Flexible structure control experiments using a real-time workstation for computer-aided control engineering

NASA Technical Reports Server (NTRS)

Stieber, Michael E.

1989-01-01

A Real-Time Workstation for Computer-Aided Control Engineering has been developed jointly by the Communications Research Centre (CRC) and Ruhr-Universitaet Bochum (RUB), West Germany. The system is presently used for the development and experimental verification of control techniques for large space systems with significant structural flexibility. The Real-Time Workstation essentially is an implementation of RUB's extensive Computer-Aided Control Engineering package KEDDC on an INTEL micro-computer running under the RMS real-time operating system. The portable system supports system identification, analysis, control design and simulation, as well as the immediate implementation and test of control systems. The Real-Time Workstation is currently being used by CRC to study control/structure interaction on a ground-based structure called DAISY, whose design was inspired by a reflector antenna. DAISY emulates the dynamics of a large flexible spacecraft with the following characteristics: rigid body modes, many clustered vibration modes with low frequencies and extremely low damping. The Real-Time Workstation was found to be a very powerful tool for experimental studies, supporting control design and simulation, and conducting and evaluating tests withn one integrated environment.

Clinical Impact and Implication of Real-Time Oscillation Analysis for Language Mapping.

PubMed

Ogawa, Hiroshi; Kamada, Kyousuke; Kapeller, Christoph; Prueckl, Robert; Takeuchi, Fumiya; Hiroshima, Satoru; Anei, Ryogo; Guger, Christoph

2017-01-01

We developed a functional brain analysis system that enabled us to perform real-time task-related electrocorticography (ECoG) and evaluated its potential in clinical practice. We hypothesized that high gamma activity (HGA) mapping would provide better spatial and temporal resolution with high signal-to-noise ratios. Seven awake craniotomy patients were evaluated. ECoG was recorded during language tasks using subdural grids, and HGA (60-170 Hz) maps were obtained in real time. The patients also underwent electrocortical stimulation (ECS) mapping to validate the suspected functional locations on HGA mapping. The results were compared and calculated to assess the sensitivity and specificity of HGA mapping. For reference, bedside HGA-ECS mapping was performed in 5 epilepsy patients. HGA mapping demonstrated functional brain areas in real time and was comparable with ECS mapping. Sensitivity and specificity for the language area were 90.1% ± 11.2% and 90.0% ± 4.2%, respectively. Most HGA-positive areas were consistent with ECS-positive regions in both groups, and there were no statistical between-group differences. Although this study included a small number of subjects, it showed real-time HGA mapping with the same setting and tasks under different conditions. This study demonstrates the clinical feasibility of real-time HGA mapping. Real-time HGA mapping enabled simple and rapid detection of language functional areas in awake craniotomy. The mapping results were highly accurate, although the mapping environment was noisy. Further studies of HGA mapping may provide the potential to elaborate complex brain functions and networks. Copyright © 2016 Elsevier Inc. All rights reserved.

Inertial sensors as real-time feedback improve learning posterior-anterior thoracic manipulation: a randomized controlled trial.

PubMed

Cuesta-Vargas, Antonio I; González-Sánchez, Manuel; Lenfant, Yves

2015-01-01

The purpose of this study was to analyze the effect of real-time feedback on the learning process for posterior-anterior thoracic manipulation (PATM) comparing 2 undergraduate physiotherapy student groups. The study design was a randomized controlled trial in an educational setting. Sixty-one undergraduate physiotherapy students were divided randomly into 2 groups, G1 (n = 31; group without feedback in real time) and G2 (n = 30; group with real-time feedback) participated in this randomized controlled trial. Two groups of physiotherapy students learned PATM, one using a traditional method and the other using real-time feedback (inertial sensor). Measures were obtained preintervention and postintervention. Intragroup preintervention and postintervention and intergroup postintervention scores were calculated. An analysis of the measures' stability was developed through an interclass correlation index. Time, displacement and velocity, and improvement (only between groups) to reach maximum peak and to reach minimum peak from maximum peak, total manipulation time, and stability of all outcome measures were the outcome measures. Statistically significant differences were found in all variables analyzed (intragroup and intergroup) in favor of G2. The values of interclass correlation ranged from 0.627 to 0.706 (G1) and between 0.881 and 0.997 (G2). This study found that the learning process for PATM is facilitated when the student receives real-time feedback. Copyright © 2015 National University of Health Sciences. Published by Elsevier Inc. All rights reserved.

Validation of the Thai version of Bergen Facebook addiction scale (Thai-BFAS). .

PubMed

Phanasathit, Muthita; Manwong, Mereerat; Hanprathet, Nitt; Khumsri, Jiraporn; Yingyeun, Rungmanee

2015-03-01

To determine the validity ofthe Thai version ofthe Bergen FacebookAddiction Scale (Thai-BFAS) using Facebook addiction screening in Thai high school students. The original BFAS was authorized for translation and validation in Thai. After content validity and usability were approved by three Thai psychiatrists, the Thai-BFAS was adjusted again by the authors and back translated by an English expert. Thisfinal version was investigated using the internal consistency method among 874 high schools students in Bangkok, Chiang Mai, Ubon Ratchathani and Songkhla, and confirmatoy factor analysis (CFA) was employed to prove that the six-component model could be representative of addiction behaviors. In addition, test-retest reliability was performed separately among 30 pilot high school students in Bangkok. The Thai-BFAS has six items, which are each scored on a 5-point scale with total score ranges from 0 to 24; the cutoff score for Facebook addition stands at least 12 points. The Cronbach s alpha coefficient was 0.91 (95% CI; 0.90, 0.92) and the inter-class correlation coefficient was 0.80 (95% CI; 0.49, 0.92). The CFA showed that the six items accurately represent the six-component model of addiction such as salience, mood modification, tolerance, withdrawal, relapse and conflict. The Thai-BFAS is consistent as a screening testfor Facebook addiction among high school students due to good reliability and validity. It also conforms well to the original version. The six items in the Thai-BFAS are a good representation of the addiction behaviors. Further studies should be undertaken in cases of sensitivity and specificity when compared with other similar tests of addiction as well as in various additional populations and circumstances.

Three-dimensional S-wave tomography under Axial Seamount

NASA Astrophysics Data System (ADS)

Baillard, C.; Wilcock, W. S. D.; Arnulf, A. F.; Tolstoy, M.; Waldhauser, F.

2017-12-01

Axial Seamount is a submarine volcano located at the intersection of the Juande Fuca Ridge and the Cobb-Eickelberg hotspot 500 km off the coast of thenorthwestern United States. The seamount, which rises 1 km above the seafloor, ischaracterized by a shallow caldera that is elongated in the N-S direction, measure 8km by 3 km and sits on top of a 14 km by 3 km magma reservoir. Two eruptive eventsin 1998 and 2011 motivated the deployment in 2014 of a real time cabled observatorywithin the Axial caldera, as part of the Ocean Observatories Initiative (OOI).Theobservatory includes a network of seven seismometers that span the southern half ofthe caldera. Five months after the observatory came on-line in November 2014, thevolcano erupted on April 24, 2015. Well over 100,000 events were located in thevicinity of the caldera, delineating an outward dipping ring fault that extends fromnear the surface to the magma body at 2 km depth and which accommodatesinflation and deflation of the volcano.The initial earthquake locations have beenobtained with a one-dimensional velocity model but the travel time residuals suggeststrong heterogeneities. A three-dimensional P-wave velocity model, obtained bycombining multichannel and ocean bottom seismometer refraction data, is being usedto refine locations but the three-dimensional S-wave structure is presently unknown.In most mid-ocean ridge settings, the distribution of earthquakes is not conducive forjoint inversions for S-wave velocity and hypocentral parameters because there are fewcrossing ray paths but at Axial the presence of a ring fault that is seismically active atall depths on both the east and west side of the caldera, provides a reasonablegeometry for such efforts. We will present the results of joint inversions that assumethe existing three-dimensional P wave velocity model and solve for VP/VS structure andhypocentral parameters using LOTOS, an algorithm that solves the forward problemusing ray bending.The resulting model of S-wave velocities will provide newconstraints on the volcanic structure of the caldera, the distribution and characteristicsof fractures, and the effects of hydrothermal circulation. The model will also lead toimproved earthquakes locations that are critical for a fine scale interpretation of thefault system.

Asteroids and Meteorites from Venus? Only the Earth Goddess Knows

NASA Astrophysics Data System (ADS)

Dones, Henry; Zahnle, Kevin J.; Alvarellos, José L.

2018-04-01

No meteorites from Venus have been found; indeed, some find theirexistence unlikely because of the perceived difficulty of launchingrocks at speeds above 10 km/s and traversing the planet's 93 baratmosphere. [1] Nonetheless, we keep hope alive, since cosmochemistssay they can identify Cytherean meteorites, should candidates be found[2]. Gladman et al. [3] modeled the exchange of impact ejecta betweenthe terrestrial planets, but did not consider meteorites launched fromVenus in any detail. At the time of Gladman's work, no asteroids thatremained entirely within Earth's orbit were known. 14 suchEarth-interior objects with good orbits have now been discovered, andare known as Atiras, for the Pawnee goddess of the Earth. The largestknown member of the class is 163693 Atira, a binary whose componentshave diameters of approximately 4.8 and 1 km. Discovery of Atiras isvery incomplete because they can only be seen at small solarelongations [4]. Greenstreet et al. [5] modeled the orbitaldistribution of Atiras from main-belt asteroidal and cometary sourceregions, while Ribeiro et al. [6] mapped the stability region ofhypothetical Atiras and integrated the orbits of clones of 12 realAtiras for 1 million years. 97% of the clones survived for 1 Myrimpact with Venus was the most common fate of those that met theirends. We have performed orbital integrations of 1000 clones of each ofthe known Atiras, and of hypothetical ejecta that escape Venus afterasteroid impacts, for 10-100 Myr. The latter calculations usetechniques like those of Alvarellos et al. [7] and Zahnle et al. [8]for transfer amongst Jupiter's galilean satellites. Our goals are toestimate the fraction of Atiras that are ejecta launched from Venus,the time spent in space by hypothetical meteorites from Venus, and therate at which such meteorites strike the Earth.[1] Gilmore M., et al (2017). Space Sci. Rev. 212, 1511. [2] JourdanF., Eroglu E. (2017). MAPS 52, 884. [3] Gladman B.J., etal. (1996). Science 271, 1387. [4] Masi G. (2003). Icarus 163,389. [5] Greenstreet S., Ngo H., Gladman B. (2012). Icarus 217,355. [6] Ribeiro A.O., et al. (2016). MNRAS 458, 4471. [7] Alvarellos,J.L., et al. (2008). Icarus 194, 636. [8] Zahnle, K., etal. (2008). Icarus 194, 660.

Impacts of Satellite Orbit and Clock on Real-Time GPS Point and Relative Positioning.

PubMed

Shi, Junbo; Wang, Gaojing; Han, Xianquan; Guo, Jiming

2017-06-12

Satellite orbit and clock corrections are always treated as known quantities in GPS positioning models. Therefore, any error in the satellite orbit and clock products will probably cause significant consequences for GPS positioning, especially for real-time applications. Currently three types of satellite products have been made available for real-time positioning, including the broadcast ephemeris, the International GNSS Service (IGS) predicted ultra-rapid product, and the real-time product. In this study, these three predicted/real-time satellite orbit and clock products are first evaluated with respect to the post-mission IGS final product, which demonstrates cm to m level orbit accuracies and sub-ns to ns level clock accuracies. Impacts of real-time satellite orbit and clock products on GPS point and relative positioning are then investigated using the P3 and GAMIT software packages, respectively. Numerical results show that the real-time satellite clock corrections affect the point positioning more significantly than the orbit corrections. On the contrary, only the real-time orbit corrections impact the relative positioning. Compared with the positioning solution using the IGS final product with the nominal orbit accuracy of ~2.5 cm, the real-time broadcast ephemeris with ~2 m orbit accuracy provided <2 cm relative positioning error for baselines no longer than 216 km. As for the baselines ranging from 574 to 2982 km, the cm-dm level positioning error was identified for the relative positioning solution using the broadcast ephemeris. The real-time product could result in <5 mm relative positioning accuracy for baselines within 2982 km, slightly better than the predicted ultra-rapid product.

Operational Implications of the NATO Strategic Concept 2010 for European Countries in NATO and the EU

DTIC Science & Technology

2011-12-01

ofthe Operational Art, by Michael 0 . Krause and Cody R. Phillips (Washington D.C.: Center of Military History, 2007), 444. The level of multinational...Werner, and Wolfgang Fett. Bericht uber das gemeinsame Berliner Colloquium 2009 von Clausewitz-Gesellschafi und Bundesakademie fiir Sicherheilspolitik...Vol. 5, in Die Jahrbiicher der C/ausewitz-Gesellschafi e. V. - Jahrbuch 2009, by Werner Baach and Wolfgang Fett, 13-24. Hamburg: C lausewitz

Detection of Accelerating Targets in Clutter Using a De-Chirping Technique

DTIC Science & Technology

2014-06-01

Academy, also in Canberra, working on the the- ory and simulation of spatial optical solitons and light-induced optical switching in nonlinear...signal gain in the receiver. UNCLASSIFIED 1 DSTO–RR–0399 UNCLASSIFIED target along the velocity vector , or equivalently by radar platform. The change of...the tracker uses range rate in its track initiation logic. (2) Lateral acceleration perpendicular to the velocity vector - the target is turning and

Characterization of Air Emissions from Open Burning and Open Detonation of Gun Propellants and Ammunition

DTIC Science & Technology

2016-11-07

To) 4. TITLE AND SUBTITLE Innovative Technology Development for Comprehensive Air Quality Characterization from Soil -Covered Open Detonation of...the short duration of the event, the heterogeneous emission concentra- tions, large plume lift, soil entrainment, and explosive safety restrictions...energetics and cased munitions, including Comp B, V453, and V548 munitions, were detonated without soil cover (only Comp B) or at soil cover depths of 3

Rock Testing Handbook (Test Standards 1993)

DTIC Science & Technology

1993-01-01

surface. ergy lost due to nonuniformity of mediums. progressive failure-formation and development of localized refusal-in grouting, when the rate of...the components of mixed grout, resulting in nonuniform across which it acts. (ISRM) proportions in the mass. shear plane-a plane along which failure of...responr, le techndcal commttee, which you may attend if you teel mt your comments have not received a lair heating you should make your views known to the

Updates to Blast Injury Criteria Models for Nuclear Casualty Estimation

DTIC Science & Technology

2015-12-01

the likelihood of blast-related injury use a two-step process. First, the maximum velocity obtained by the human body or secondary missile is determined...the human body . Secondary injuries are caused by missiles that are accelerated by the blast wave. Tertiary injuries are caused by the acceleration of...the human body and the ensuing deceleration. In this work, we focus on secondary and tertiary injuries. Because of the dramatic effects experienced

Development of Fluidic Guidance for KEW (Kinetic Energy Weapon) Projectiles

DTIC Science & Technology

1988-12-30

commanded to a hit-to-kill on a hostile ICBK booster. A novel application of-the photo-acoustic effect is used for laser detection. An acoustic wave...Hughes High Endo-Atmospheric Interceptor Concept.. 2 3 Conceptual SDI KE projectile ........................ 3 4 Schematic of photo-acoustic effect ...practical, KEWs must be lightweight, able to withstand high "g" forces, and insensitive to nuclear and electro-magnetic effects . Laser command guidance can

Biologic and Computational Modeling of Mammographic Density and Stromal Patterning

DTIC Science & Technology

2009-07-01

research effort. INTRODUCTION: Mammographic density serves as independent marker of short term breast cancer risk and a surrogate marker of...response to a variety of prevention agents1-3. Although a majority of breast cancers are epithelial in origin, there is evidence that stromal content of...the breast is an important predictor or mammographic density. There is increasing evidence that the stroma plays a role in breast cancer initiation4

Self-Critical, and Robust, Procedures for the Analysis of Multivariate Normal Data.

DTIC Science & Technology

1982-06-01

Influence Functions The influence function is the most important tt of qual- itative zobustness since many other robustness characteristics of an estimator...may be derived from it. The influence function characterizes the (asymptotic) response of an estimator to an additional observation as a function of...the influence function be bounded. It is also advantageous, in our opinion, if the influence functions are re-descending to zero. The influence function for

High Temperature Texturing of Engineered Materials in a Magnetic Field

DTIC Science & Technology

2003-03-01

by 43.7 % after magnetic annealing in a 19 T field. The kink at the demagnetization curve disappeared and, in addition, a much better squareness of...the demagnetization curves was observed after the magnetic annealing (Figure 10). The improvement in the hard magnetic properties after magnetic ...A number of materials systems have been tested in a variety of magnetic fields (8-20 Tesla) and temperatures (500 to 1250oC). Four materials

Total Quality Management: Implications for Nursing Information Systems

DTIC Science & Technology

1992-01-01

the Defense Department’s TQM model (see Appendix M) and TQM master plan (see Appendix N) (Hunt, 1992). Ishikawa . Kaoru Ishikawa was the best known of...the subject -- Deming, Juran, Crosby, Feigenbaum, Ishikawa , etc. (see Chapter 2). One of the most concise definitions on TQM was given in a speech by...with the contributions of key quality authors, including Deming, Juran, Crosby, Costello, and Ishikawa . The use of TQM in business and in healthcare

Worldwide Buoy Technology Survey. Volume 2. Appendix B. Buoy Records. Book 2. Germany - USA

DTIC Science & Technology

1991-02-01

arrangement and effectiveness of the complete system could not be addressed in detail within the constraints of this project. In an overall evaluation of...the SRA system , such considerations should also be addressed. The USCG’s Waterway Analysis and Management System (WAMS) is considering this matter as...project. The task includes the screening of worldwide engineering and technical information on buoy systems , approaches to problem solving (particularly

Environmental Assessment for Management of South End of Runway Wetlands, Moody AFB, Georgia

DTIC Science & Technology

2010-11-01

implement a management program for the wetlands at the south end of runway (EOR) at Moody AFB to reduce the bird/wildlife aircraft strike hazard (BASH) risk...because birds and other wildlife pose an increased bird/wildlife aircraft strike hazard (BASH) risk to aircraft utilizing the Moody AFB airfield. ln...support ofthe military mission, Moody AFB has implemented a BASH management program designed to minimize aircraft exposure to potentially hazardous

Evaluation of the Impact of an Additive Manufacturing Enhanced CubeSat Architecture on the CubeSat Development Process

DTIC Science & Technology

2016-09-15

EVALUATION OF THE IMPACT OF AN ADDITIVE MANUFACTURING ENHANCED CUBESAT ARCHITECTURE ON THE CUBESAT...DEVELOPMENT PROCESS THESIS Rachel E. Sharples AFIT-ENV-MS-16-S-049 DEPARTMENT OF THE AIR FORCE AIR UNIVERSITY AIR FORCE INSTITUTE OF...The views expressed in this thesis are those of the author and do not reflect the official policy or position of the United States Air Force

Human-Powered Helicopter: A Program for Design and Construction

DTIC Science & Technology

1991-06-01

that for the Gossamer Albatross , it was surprising that members of both teams felt that the most difficult obstacle was the travel and transportation of...the aircraft, crew and support equipment [Ref.4: p.120]. Both the Gossamer Albatross and the Daedalus projects were required to travel to Europe...to the degree anticipated. The Daedalus prototype, called the Light Eagle, was designed to break the Gossamer Albatross distance record of 21 miles

Defense Commissary Agency Financial Reporting of Property, Plant, and Equipment.

DTIC Science & Technology

1998-03-27

ort DEFENSE COMMISSARY AGENCY FINANCIAL REPORTING OF PROPERTY, PLANT, AND EQUIPMENT Report Number 98-097 March 27, 1998 Office of the Inspector...UNDER SECRETARY OF DEFENSE (COMPTROLLER) DIRECTOR, DEFENSE COMMISSARY AGENCY SUBJECT: Audit Report on Defense Commissary Agency Financial Reporting of...the costs of the capital assets used to p erform the DeCA mission were in accordance with DoD financial reporting policy, and whether the FY 1996 DeCA

The Ecology and Environmental Impact of Marshland and Estuaries

DTIC Science & Technology

1992-12-15

species of water snakes, blue runners , ribbon snakes, black snakes, and bull snakes, as well as water moccassins, rattlesnakes, copperheads, and coral...be encountered there that should receive special consideration is the swallow-tailed kite . Kites in general seem to be seriously declining in parts of...the southern U.S., and a couple have a tenuous hold on their environment or, in the case of the swallow-tailed kite , have an undetermined status

Coast Guard Deepwater Acquisition Programs: Background, Oversight Issues, and Options for Congress

DTIC Science & Technology

2010-09-29

NUMBER 5e . TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Congressional Research Service,The Library of...the role to Integrated Coast Guard Systems (ICGS)—an industry team led by Lockheed Martin and Northrop Grumman Ship Systems ( NGSS ). ICGS was...of individual Deepwater assets. The Coast Guard’s own management policies are generally aligned with DHS directives, although operational testing

Role of Mitochondrial Inheritance on Prostate Cancer Outcome in African American Men. Addendum

DTIC Science & Technology

2016-11-01

DNA sequencing technique developed by our collaborator using single amplicon long-range PCR that permits deep coverage (10,000-20,000X on average) of...the mitochondrial genome. We have sequenced 652 samples derived from frozen fully using this technology. The additional DNA samples derived from...paraffin embedded (FFPE) tissue were more challenging, but have now been sequenced . Mapping of DNA variants in our sequenced genomes to mitochondrial

Modeling and Control of Intelligent Flexible Structures

DTIC Science & Technology

1994-03-26

can be approximated as a simply supported beam in transverse vibration. Assuming that the Euler- Bernoulli beam assumptions hold, linear equations of...The assumptions made during the derivation are that the element can be modeled as an Euler- Bernoulli beam, that the cross-section is symmetric, and...parametes A,. and ,%. andc input maces 3,,. The closed loop system. ecuation (7), is stable when the 3.. 8 and output gain mantices H1., H., H. for

Nodes

NASA Technical Reports Server (NTRS)

Hanson, John; Martinez, Andres; Petro, Andrew

2015-01-01

Nodes is a technology demonstration mission that is scheduled for launch to the International SpaceStation no earlier than Nov.19, 2015. The two Nodes satellites will be deployed from the Station in early 2016 todemonstrate new network capabilities critical to the operation of swarms of spacecraft. They will demonstrate the ability ofmulti spacecraft swarms to receive and distribute ground commands, exchange information periodically, andautonomously configure the network by determining which spacecraft should communicate with the ground each day ofthe mission.

A Program for Computing Steady Inviscid Three-Dimensional Supersonic Flow on Reentry Vehicles. Volume I: Analysis and Programming

DTIC Science & Technology

1977-02-11

Continue an reverse aide If necessaty and Identify by block number) A comprehensive computational procedure is presented for predicting the...Aeroballistic Reentry Technology ( ART ) program with some of the fundamental analytical and numerical work supported by NSWC Independent Research Funds. Most of...the Aerospace Corporation. The authors gratefully acknowledge the efforts of Mr. R. Feldhuhn, NSWC coordinator for the ART program, who was responsible

Conduct and Accountability; A Report to the President.

DTIC Science & Technology

1986-06-01

developments ats passage o)fthe E~thics in] () % I I ertI eitI cto I f19 7 8. F venI inII’ Ir its cret v ers1 in , D I re c t Ive 550O. 7 1) rovId(Ie s milly...part, that, ’The Plant Rep/ACO is the team contractors’ policies, procedures, manager for all PCO requests for field pric ing controls, and practices

Toward an Operational Definition of Workload: A Workload Assessment of Aviation Maneuvers

DTIC Science & Technology

2010-08-01

and evaluated by the learner . With practice, the learner moves into the second phase, where optimal strategies are strengthened. The final stage of...The first phase demands a great amount of resources as performance is slow and prone to errors. During this phase, strategies are being formulated...asked to assess mental, physical, visual, aural , and verbal demands of each task. The new assessment is a cost effective method of assessing workload

Evaluation of the National Register Eligibility of the Inner Harbor Navigation Canal Lock in Orleans Parish, Louisiana.

DTIC Science & Technology

1987-06-15

INTRODUCTIONo ....... .. .......... _..*.. ........ o... 19 The Inner Harbor Navigation Canal Complex............19 Sources Used During Research...PAGE BLANK Sources Used During Research The archival sources utilized during the research for the project include: Annual Reports to the Chief of...the term used to describe a condition where the earth is eroded by an underground source of water. The effect of this type of erosion would be that

In Vivo Determination of the Complex Elastic Moduli of Cetacean Head Tissue

DTIC Science & Technology

2013-09-30

of an ultrasonic Doppler vibration measurement system called NVMS developed at Georgia Tech iii. Algorithms have been developed to enable the...magnitude and phase of vibration to be determined as a function of range (tissue depth) along the ultrasonic beam. By measuring the differential phase of...The frequency dependence of the propagation speed is then used to determine the shear loss factor. The elastic properties of tissue phantoms

Annotated Bibliography of Reports. Supplement Number 11, 1 October 1978 - 30 September 1979.

DTIC Science & Technology

1979-09-30

examination for Schistosoma ova are described. NAMRL 78-9 Enteric Parasites of Orangutans (Pongo (AD A073530) pygameaeus) in Indonesia Richard J. Brown...species of nonhuman primates. The treatment of diarrheal diseases in the less widely used nonhuman primates, such as orangutans , is difficult because of...the lack of information as to possible etiologic agents. This paper tabulates identified enteric parasitic ova in three groups of orangutans living in

A ’Single Audit’ Model for Federal Credit Unions.

DTIC Science & Technology

1981-06-01

role of internal auditing in appraising the performance of management and the basic knowledge an internal auditor must possess. The last section of...the separate phases of a per- formance audit are explained as well as the role of the auditor in each phase. 1. Defining the Audit Objective Auditors ...Additionally, the auditor must review each investment to determine if security and liquidity requirements are maintained. (2) Planning Role . The

Process Guide for the Domain-Specific Software Architectures (DSSA) Process Life Cycle

DTIC Science & Technology

1993-12-01

of box "Things" used and transformed by activities Output Right side of box...Carnegie Mellon University is required not to chsc’lmirate in admission. employment or administration of its programs on the oasis of race. color...natonal Origin sex of hanoicap ,:zlaon of Tit!e VI of.the C~vii RAgtts A - of 964 Tile ’X of ’he Educationai Amendments of 1972 and Sectlon 504 of

Nutrition and Resistance to Climatic Stress; With Particular Reference to Man

DTIC Science & Technology

1949-11-01

significantly to o~rational efficiency, or may reduce significantly the hazard of explosive decompression resulting from combat, when seconds of...the low 1 partial pressure of oxygen in the inspired air is a type of climatic stress presenting a serious hazard to the preservation of...oxygen is a complete defense against this hazard except in combat or in accident. The breath- ing of pure oxygen in an airplane cabin not so

Ideas, Concepts, Doctrine: Basic Thinking in the United States Air Force, 1961-1984. Volume 2

DTIC Science & Technology

1989-12-01

followed in this new second volume. Dr David MacIsaac, a$sociate director for research, Airpower Research Institute, stimulated much ofthe thinking...us a capability to observe and report the physical evidence of an enemy’s situation . This information is a vital requirement for the conduct of war...asking questions, suggesting alternatives, proposing objectives, stimulating progress .»79 As has been seen, McNamara immediately implemented

Acme Landfill Expansion. Appendices.

DTIC Science & Technology

1982-01-01

refuse collectors. These areas were determined by using existing franchise boundaries and projected *spheres of influence" for future expansion of...The cost mitigations used in Table 15 include: an incre-se in average net revenue per ton to $30, franchise fees, Interest free loans, a grant for...Tons per day 32 16 Tons per year-/ 7,700 3,800 REVENUES ($30.00 per ton) $231,000 $114,000 FRANCHISE FEES 70,000 70,00u EXPENSES Annualized Capital

Infrared Spectroscopic Imaging for Prostate Pathology Practice

DTIC Science & Technology

2011-04-01

features – geometric properties of epithelial cells/nuclei and lumens – that are quantified based on H&E stained images as well as FT-IR images of...the samples. By restricting the features used to geometric measures, we sought to mimic the pattern recognition process employed by human experts, and...relatively dark and can be modeled as small elliptical areas in the stained images. This geometrical model is often confounded as multiple nuclei can be

Environmental Requirements for Authentication Protocols

DTIC Science & Technology

2002-01-01

Engineering for Informa- tion Security, March 2001. 10. D. Chaum . Blind signatures for untraceable payments. In Advances in Cryptology{ Proceedings of...the connection, the idea relies on a concept similar to blinding in the sense of Chaum [10], who used it e ectively in the design of anonymous payment...digital signature on the key and a nonce provided by the server, in which the client’s challenge response was independent of the type of cipher

Characterization and Consequences of Estrogen Receptor Exon Five Deletion.

DTIC Science & Technology

1998-08-01

and ending with ovulation), and the luteal or secretory phase (beginning with ovulation and ending with the onset of menses) (7). Early in the...7), the primary site of both progesterone and estrogen biosynthesis during the luteal phase 3 (estrogen production remains elevated through most of...the luteal phase, 250ug/day, and progesterone production peaks in the mid- luteal phase, 10-40mg/day) (7). If implantation does not occur gonadotropin

Armed Services Exchange Regulations

DTIC Science & Technology

1986-12-15

The Use of Nonappropriated Funds, Other Than By Military Exchanges," August 28, 1974 (d) through (n), see enclosure 1 A. REISSUANCE AND PURPOSE This...sale in commissary stores as listed in DoD Directive 1330.17 (reference (b)). The basic authorization for resale activities conducted with the use of...the other Military Departments. 2-1 PART 2--DEFINITIONS OF TERMS 1-201. Definitions. Terms used in this Regulation are defined as tollows: 1-201.1

Deciding to be Violent: The Perceived Utility of Abusive Behavior in Marriage

DTIC Science & Technology

1997-12-11

Following are some ofthe more important circumstances where a release ofinformation is required by State and Federal Law and/or Military Regulation: 1...release ofinformation is required by State and Federal Law and Military Regulation: 1. Ifyou disclose information about the neglect or abuse ofpeople...where a release ofinformation is required by State and Federal Law and Military Regulation: 1. Ifyou disclose information about the neglect or abuse

The Coast Artillery Journal. Volume 68, Number 2, February 1928

DTIC Science & Technology

1928-02-01

presentation makes it possible for the uninitated to picture readily a wiring diagram in its full meaning. For those who would compute rapidly, and to a...probably organic army artillery, thus computed , would be better, with, in addition, quotas of G. H. Q. Artillery provided for various sized groups of...the computation of antiaircraft deflections, and it is to satisfy their very natural curiosity with regard particularly to the improving factor and the

Crossing Our Red Lines About Partner Engagement in Mexico

DTIC Science & Technology

2013-03-01

aware that notwithstanding any other provision of law , no person shall be subject to any penalty for failing to comply with a collection of...the United States is willing to provide the military or law enforcement forces required to adequately control the international border or the...war on drugs. Americans demand that Mexico do a better job of imposing the rule of law within its own borders. Both positions divert attention away

Isolated Posterior Cerebral Artery Dissection: Report of Three Cases

DTIC Science & Technology

2005-08-31

hemiparesis that appeared shortly after her older sister had accidentally dropped the edge of a mattress on the top of her head. There was no loss of...the emergency department, he had a right homonymous hemianopsia and a mild right hemiparesis . Noncontrast brain CT showed hypoattenuation in the left...aspirin per day throughout his hospital course and showed mild improvement of his hemiparesis and a decrease in his visual field deficit. The patient did

Mapping Flows onto Networks to Optimize Organizational Processes

DTIC Science & Technology

2005-01-01

And G . Porter, “Assessments of Simulated Performance of Alternative Architectures for Command and Control: The Role of Coordination”, Proceedings of...the 1999 Command & Control Research & Technology Symposium, NWC, Newport, RI, June 1999, pp. 123-143. [Iverson95] M. Iverson, F. Ozguner, G . Follen...Technology Symposium, NPS, Monterrey, CA, June, 2002. [Wu88] Min-You Wu, D. Gajski . “A Programming Aid for Hypercube Architectures.” The Journal of Supercomputing, 2(1988), pp. 349-372.

Gas bubbles in fossil amber as possible indicators of the major gas composition of ancient air

USGS Publications Warehouse

Berner, R.A.; Landis, G.P.

1988-01-01

Gases trapped in Miocene to Upper Cretaceous amber were released by gently crushing the amber under vacuum and were analyzed by quadrupole mass spectrometry. After discounting the possibility that the major gases N2, O2, and CO2 underwent appreciable diffusion and diagenetic exchange with their surroundings or reaction with the amber, it has been concluded that in primary bubbles (gas released during initial breakage) these gases represent mainly original ancient air modified by the aerobic respiration of microorganisms. Values of N2/(CO2+O2) for each time period give consistent results despite varying O2/CO2 ratios that presumably were due to varying degrees of respiration. This allows calculation of original oxygen concentrations, which, on the basis of these preliminary results, appear to have changed from greater than 30 percent O2 during one part ofthe Late Cretaceous (between 75 and 95 million years ago) to 21 percent during the Eocene-Oligocene and for present-day samples, with possibly lower values during the Oligocene-Early Miocene. Variable O2 levels over time in general confirm theoretical isotope-mass balance calculations and suggest that the atmosphere has evolved over Phanerozoic time.

Diagnosis and identification of Leishmania spp. from Giemsa-stained slides, by real-time PCR and melting curve analysis in south-west of Iran.

PubMed

Khademvatan, S; Neisi, N; Maraghi, S; Saki, J

2011-12-01

The aim of present study was describing a real-time PCR assay for the diagnosis and direct identification of Leishmania species on Giemsa-stained slides in south-west of Iran. Altogether, 102 Giemsa-stained slides were collected from different part of south-west of Iran between 2008 and 2011. All the Giemsa-stained slides were examined under light microscope. After DNA extraction, real-time PCR amplification and detection were conducted with fluorescent SYBR Green I. For identification, PCR products were analysed with melting curve analysis. One hundred and two archived slides from suspected lesion examined by microscopy and real-time PCR. The sensitivity of the real-time PCR on Giemsa-stained slid was 98% (96/102). The melting curve analysis (T(m)) were 88·3±0·2°C for L. tropica (MHOM/IR/02/Mash10), 86·5±0·2°C for L. major (MHOM/IR/75/ER) and 89·4±0·3°C for L. infantum (MCAN/IR/97/LON 49), respectively. This study is first report in use of real-time PCR for diagnosis and identification of Leishmania spp. in Iran. Up to now, in Iran, the majority of identification of Leishmania species is restriction fragment length polymorphism (PCR-RFLP) of ITS1 and kinetoplast DNA. Our data showed that Giemsa-stained slides that were stored more than 3 years, can be use for Leishmania DNA extraction and amplification by real-time PCR. Compared to conventional PCR-based methods, the real-time PCR is extremely rapid with results and more samples can be processed at one time.

Comparative study of predicted and experimentally detected interplanetary shocks

NASA Astrophysics Data System (ADS)

Kartalev, M. D.; Grigorov, K. G.; Smith, Z.; Dryer, M.; Fry, C. D.; Sun, Wei; Deehr, C. S.

2002-03-01

We compare the real time space weather prediction shock arrival times at 1 AU made by the USAF/NOAA Shock Time of Arrival (STOA) and Interplanetary Shock Propagation Model (ISPM) models, and the Exploration Physics International/University of Alaska Hakamada-Akasofu-Fry Solar Wind Model (HAF-v2) to a real time analysis analysis of plasma and field ACE data. The comparison is made using an algorithm that was developed on the basis of wavelet data analysis and MHD identification procedure. The shock parameters are estimated for selected "candidate events". An appropriate automatically performing Web-based interface periodically utilizes solar wind observations made by the ACE at L1. Near real time results as well an archive of the registered interesting events are available on a specially developed web site. A number of events are considered. These studies are essential for the validation of real time space weather forecasts made from solar data.

The accuracy of real-time procedure coding by theatre nurses: a comparison with the central national system.

PubMed

Maclean, Donald; Younes, Hakim Ben; Forrest, Margaret; Towers, Hazel K

2012-03-01

Accurate and timely clinical data are required for clinical and organisational purposes and is especially important for patient management, audit of surgical performance and the electronic health record. The recent introduction of computerised theatre management systems has enabled real-time (point-of-care) operative procedure coding by clinical staff. However the accuracy of these data is unknown. The aim of this Scottish study was to compare the accuracy of theatre nurses' real-time coding on the local theatre management system with the central Scottish Morbidity Record (SMR01). Paired procedural codes were recorded, qualitatively graded for precision and compared (n = 1038). In this study, real-time, point-of-care coding by theatre nurses resulted in significant coding errors compared with the central SMR01 database. Improved collaboration between full-time coders and clinical staff using computerised decision support systems is suggested.

Real-time RPA assay for rapid detection and differentiation of wild-type pseudorabies and gE-deleted vaccine viruses.

PubMed

Wang, Jianchang; Liu, Libing; Wang, Jinfeng; Pang, Xiaoyu; Yuan, Wanzhe

2018-02-15

The objective of this study was to develop a dual real-time recombinase polymerase amplification (RPA) assay using exo probes for the detection and differentiation of pseudorabies virus (PRV). Specific RPA primers and probes were designed for gB and gE genes of PRV within the conserved region of viral genome. The reaction process can be completed in 20 min at 39 °C. The dual real-time RPA assay performed in the single tube was capable of specific detecting and differentiating of the wild-type PRV and gE-deleted vaccine strains, without cross-reactions with other non-targeted pig viruses. The analytical sensitivity of the assay was 10 2 copies for gB and gE genes. The dual real-time RPA demonstrated a 100% diagnostic agreement with the real-time PCR on 4 PRV strains and 37 clinical samples. Through the linear regression analysis, the R 2 value of the real-time RPA and the real-time PCR for gB and gE was 0.983 and 0.992, respectively. The dual real-time RPA assay provides an alternative useful tool for rapid, simple, and reliable detection and differentiation of PRV, especially in remote and rural areas. Copyright © 2017 Elsevier Inc. All rights reserved.

Introducing automation to the molecular diagnosis of Trypanosoma cruzi infection: A comparative study of sample treatments, DNA extraction methods and real-time PCR assays.

PubMed

Abras, Alba; Ballart, Cristina; Llovet, Teresa; Roig, Carme; Gutiérrez, Cristina; Tebar, Silvia; Berenguer, Pere; Pinazo, María-Jesús; Posada, Elizabeth; Gascón, Joaquim; Schijman, Alejandro G; Gállego, Montserrat; Muñoz, Carmen

2018-01-01

Polymerase chain reaction (PCR) has become a useful tool for the diagnosis of Trypanosoma cruzi infection. The development of automated DNA extraction methodologies and PCR systems is an important step toward the standardization of protocols in routine diagnosis. To date, there are only two commercially available Real-Time PCR assays for the routine laboratory detection of T. cruzi DNA in clinical samples: TCRUZIDNA.CE (Diagnostic Bioprobes Srl) and RealCycler CHAG (Progenie Molecular). Our aim was to evaluate the RealCycler CHAG assay taking into account the whole process. We assessed the usefulness of an automated DNA extraction system based on magnetic particles (EZ1 Virus Mini Kit v2.0, Qiagen) combined with a commercially available Real-Time PCR assay targeting satellite DNA (SatDNA) of T. cruzi (RealCycler CHAG), a methodology used for routine diagnosis in our hospital. It was compared with a well-known strategy combining a commercial DNA isolation kit based on silica columns (High Pure PCR Template Preparation Kit, Roche Diagnostics) with an in-house Real-Time PCR targeting SatDNA. The results of the two methodologies were in almost perfect agreement, indicating they can be used interchangeably. However, when variations in protocol factors were applied (sample treatment, extraction method and Real-Time PCR), the results were less convincing. A comprehensive fine-tuning of the whole procedure is the key to successful results. Guanidine EDTA-blood (GEB) samples are not suitable for DNA extraction based on magnetic particles due to inhibition, at least when samples are not processed immediately. This is the first study to evaluate the RealCycler CHAG assay taking into account the overall process, including three variables (sample treatment, extraction method and Real-Time PCR). Our findings may contribute to the harmonization of protocols between laboratories and to a wider application of Real-Time PCR in molecular diagnostic laboratories associated with health centers.

Detection of Yersinia Enterocolitica Species in Pig Tonsils and Raw Pork Meat by the Real-Time Pcr and Culture Methods.

PubMed

Stachelska, M A

2017-09-26

The aim of the present study was to establish a rapid and accurate real-time PCR method to detect pathogenic Yersinia enterocolitica in pork. Yersinia enterocolitica is considered to be a crucial zoonosis, which can provoke diseases both in humans and animals. The classical culture methods designated to detect Y. enterocolitica species in food matrices are often very time-consuming. The chromosomal locus _tag CH49_3099 gene, that appears in pathogenic Y. enterocolitica strains, was applied as DNA target for the 5' nuclease PCR protocol. The probe was labelled at the 5' end with the fluorescent reporter dye (FAM) and at the 3' end with the quencher dye (TAMRA). The real-time PCR cycling parameters included 41 cycles. A Ct value which reached a value higher than 40 constituted a negative result. The developed for the needs of this study qualitative real-time PCR method appeared to give very specific and reliable results. The detection rate of locus _tag CH49_3099 - positive Y. enterocolitica in 150 pig tonsils was 85 % and 32 % with PCR and culture methods, respectively. Both the Real-time PCR results and culture method results were obtained from material that was enriched during overnight incubation. The subject of the study were also raw pork meat samples. Among 80 samples examined, 7 ones were positive when real-time PCR was applied, and 6 ones were positive when classical culture method was applied. The application of molecular techniques based on the analysis of DNA sequences such as the Real-time PCR enables to detect this pathogenic bacteria very rapidly and with higher specificity, sensitivity and reliability in comparison to classical culture methods.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eto, Joseph H.; Parashar, Manu; Lewis, Nancy Jo

The Real Time System Operations (RTSO) 2006-2007 project focused on two parallel technical tasks: (1) Real-Time Applications of Phasors for Monitoring, Alarming and Control; and (2) Real-Time Voltage Security Assessment (RTVSA) Prototype Tool. The overall goal of the phasor applications project was to accelerate adoption and foster greater use of new, more accurate, time-synchronized phasor measurements by conducting research and prototyping applications on California ISO's phasor platform - Real-Time Dynamics Monitoring System (RTDMS) -- that provide previously unavailable information on the dynamic stability of the grid. Feasibility assessment studies were conducted on potential application of this technology for small-signal stabilitymore » monitoring, validating/improving existing stability nomograms, conducting frequency response analysis, and obtaining real-time sensitivity information on key metrics to assess grid stress. Based on study findings, prototype applications for real-time visualization and alarming, small-signal stability monitoring, measurement based sensitivity analysis and frequency response assessment were developed, factory- and field-tested at the California ISO and at BPA. The goal of the RTVSA project was to provide California ISO with a prototype voltage security assessment tool that runs in real time within California ISO?s new reliability and congestion management system. CERTS conducted a technical assessment of appropriate algorithms, developed a prototype incorporating state-of-art algorithms (such as the continuation power flow, direct method, boundary orbiting method, and hyperplanes) into a framework most suitable for an operations environment. Based on study findings, a functional specification was prepared, which the California ISO has since used to procure a production-quality tool that is now a part of a suite of advanced computational tools that is used by California ISO for reliability and congestion management.« less

Performance Evaluation of Real-Time Precise Point Positioning Method

NASA Astrophysics Data System (ADS)

Alcay, Salih; Turgut, Muzeyyen

2017-12-01

Post-Processed Precise Point Positioning (PPP) is a well-known zero-difference positioning method which provides accurate and precise results. After the experimental tests, IGS Real Time Service (RTS) officially provided real time orbit and clock products for the GNSS community that allows real-time (RT) PPP applications. Different software packages can be used for RT-PPP. In this study, in order to evaluate the performance of RT-PPP, 3 IGS stations are used. Results, obtained by using BKG Ntrip Client (BNC) Software v2.12, are examined in terms of both accuracy and precision.

Developing infrared array controller with software real time operating system

NASA Astrophysics Data System (ADS)

Sako, Shigeyuki; Miyata, Takashi; Nakamura, Tomohiko; Motohara, Kentaro; Uchimoto, Yuka Katsuno; Onaka, Takashi; Kataza, Hirokazu

2008-07-01

Real-time capabilities are required for a controller of a large format array to reduce a dead-time attributed by readout and data transfer. The real-time processing has been achieved by dedicated processors including DSP, CPLD, and FPGA devices. However, the dedicated processors have problems with memory resources, inflexibility, and high cost. Meanwhile, a recent PC has sufficient resources of CPUs and memories to control the infrared array and to process a large amount of frame data in real-time. In this study, we have developed an infrared array controller with a software real-time operating system (RTOS) instead of the dedicated processors. A Linux PC equipped with a RTAI extension and a dual-core CPU is used as a main computer, and one of the CPU cores is allocated to the real-time processing. A digital I/O board with DMA functions is used for an I/O interface. The signal-processing cores are integrated in the OS kernel as a real-time driver module, which is composed of two virtual devices of the clock processor and the frame processor tasks. The array controller with the RTOS realizes complicated operations easily, flexibly, and at a low cost.

Improving the Robustness of Real-Time Myoelectric Pattern Recognition against Arm Position Changes in Transradial Amputees

PubMed Central

Geng, Yanjuan; Wei, Yue

2017-01-01

Previous studies have showed that arm position variations would significantly degrade the classification performance of myoelectric pattern-recognition-based prosthetic control, and the cascade classifier (CC) and multiposition classifier (MPC) have been proposed to minimize such degradation in offline scenarios. However, it remains unknown whether these proposed approaches could also perform well in the clinical use of a multifunctional prosthesis control. In this study, the online effect of arm position variation on motion identification was evaluated by using a motion-test environment (MTE) developed to mimic the real-time control of myoelectric prostheses. The performance of different classifier configurations in reducing the impact of arm position variation was investigated using four real-time metrics based on dataset obtained from transradial amputees. The results of this study showed that, compared to the commonly used motion classification method, the CC and MPC configurations improved the real-time performance across seven classes of movements in five different arm positions (8.7% and 12.7% increments of motion completion rate, resp.). The results also indicated that high offline classification accuracy might not ensure good real-time performance under variable arm positions, which necessitated the investigation of the real-time control performance to gain proper insight on the clinical implementation of EMG-pattern-recognition-based controllers for limb amputees. PMID:28523276

Evaluation of quantification methods for real-time PCR minor groove binding hybridization probe assays.

PubMed

Durtschi, Jacob D; Stevenson, Jeffery; Hymas, Weston; Voelkerding, Karl V

2007-02-01

Real-time PCR data analysis for quantification has been the subject of many studies aimed at the identification of new and improved quantification methods. Several analysis methods have been proposed as superior alternatives to the common variations of the threshold crossing method. Notably, sigmoidal and exponential curve fit methods have been proposed. However, these studies have primarily analyzed real-time PCR with intercalating dyes such as SYBR Green. Clinical real-time PCR assays, in contrast, often employ fluorescent probes whose real-time amplification fluorescence curves differ from those of intercalating dyes. In the current study, we compared four analysis methods related to recent literature: two versions of the threshold crossing method, a second derivative maximum method, and a sigmoidal curve fit method. These methods were applied to a clinically relevant real-time human herpes virus type 6 (HHV6) PCR assay that used a minor groove binding (MGB) Eclipse hybridization probe as well as an Epstein-Barr virus (EBV) PCR assay that used an MGB Pleiades hybridization probe. We found that the crossing threshold method yielded more precise results when analyzing the HHV6 assay, which was characterized by lower signal/noise and less developed amplification curve plateaus. In contrast, the EBV assay, characterized by greater signal/noise and amplification curves with plateau regions similar to those observed with intercalating dyes, gave results with statistically similar precision by all four analysis methods.

Space-borne Chlorophyll Fluorescence, Greenness, Vegetation Models and Interannual Variability of Photosynthetic Activity: Spatio-temporal Patterns, Mechanisms, and Environmental Sensitivities

NASA Astrophysics Data System (ADS)

Walther, S.; Guanter, L.; Jung, M.; Frankenberg, C.; Sun, Y.; Forkel, M.; Zhang, Y.; Duveiller, G.; Cescatti, A.; Camps-Valls, G.; Köhler, P.

2016-12-01

It is much debated whether respiration or photosynthesis drive net ecosystem productivity andwhich regions contribute strongest to the observed interannual variability (IAV) of the strengthof the land sink. Several studies point to photosynthetic productivity in semi-arid regions as avery important factor influencing atmospheric CO2 variability globally (e.g. Jung et al., 2011;Poulter et al., 2014; Ahlstr ̈ om et al., 2015). Here, we aim at a comprehensive comparison ofthe strength, timing and spatial extent of anomalies of photosynthesis as they are indicated bysatellite observations of greenness, vegetation optical depth, and sun-induced chlorophyll fluo-rescence (SIF). We will compare them to the results of diagnostic, empirical and process-basedvegetation models. Except for the evergreen tropics, the spatio-temporal patterns of monthlydominant vegetation variability are generally consistently shown in semi-arid areas, albeit withdiffering magnitudes between greenness and photosynthesis globally. Relative anomalies (to themean seasonal cycle) are particularly widespread in high northern latitudes. Further researchsteps will include i) the repeated analysis at higher temporal resolution to better refine the dif-ferent time scales of reaction between light-use-efficiency and APAR and between forestedand non-forested ecosystems, ii) investigate on characteristic time scales at which the proxies(dis-)agree and why, iii) study the relative contributions of anomalies in peak and length of thegrowing season to IAV (similar to Xia et al., 2015; Zhou et al., 2016), iv) analyse the proxiesfor possibly differing hydrological sensitivities, and v) vegetation models have long been knownto have very diverse abilities to capture GPP IAV. Our preliminary results confirm this and wewill further study possible limitations and possible ways for improvement of the simulations.

Improved dual-loop detection system for collecting real-time truck data

DOT National Transportation Integrated Search

2005-02-01

The WSDOTs dual-loop detectors capability of measuring vehicle lengths makes the dual-loop detection system a potential real-time truck data source for freight movement study. However, a previous study found the WSDOT dual-loop detection system...

A real-time digital computer program for the simulation of a single rotor helicopter

NASA Technical Reports Server (NTRS)

Houck, J. A.; Gibson, L. H.; Steinmetz, G. G.

1974-01-01

A computer program was developed for the study of a single-rotor helicopter on the Langley Research Center real-time digital simulation system. Descriptions of helicopter equations and data, program subroutines (including flow charts and listings), real-time simulation system routines, and program operation are included. Program usage is illustrated by standard check cases and a representative flight case.

Far-field photostable optical nanoscopy (PHOTON) for real-time super-resolution single-molecular imaging of signaling pathways of single live cells

NASA Astrophysics Data System (ADS)

Huang, Tao; Browning, Lauren M.; Xu, Xiao-Hong Nancy

2012-04-01

Cellular signaling pathways play crucial roles in cellular functions and design of effective therapies. Unfortunately, study of cellular signaling pathways remains formidably challenging because sophisticated cascades are involved, and a few molecules are sufficient to trigger signaling responses of a single cell. Here we report the development of far-field photostable-optical-nanoscopy (PHOTON) with photostable single-molecule-nanoparticle-optical-biosensors (SMNOBS) for mapping dynamic cascades of apoptotic signaling pathways of single live cells in real-time at single-molecule (SM) and nanometer (nm) resolutions. We have quantitatively imaged single ligand molecules (tumor necrosis factor α, TNFα) and their binding kinetics with their receptors (TNFR1) on single live cells; tracked formation and internalization of their clusters and their initiation of intracellular signaling pathways in real-time; and studied apoptotic signaling dynamics and mechanisms of single live cells with sufficient temporal and spatial resolutions. This study provides new insights into complex real-time dynamic cascades and molecular mechanisms of apoptotic signaling pathways of single live cells. PHOTON provides superior imaging and sensing capabilities and SMNOBS offer unrivaled biocompatibility and photostability, which enable probing of signaling pathways of single live cells in real-time at SM and nm resolutions.Cellular signaling pathways play crucial roles in cellular functions and design of effective therapies. Unfortunately, study of cellular signaling pathways remains formidably challenging because sophisticated cascades are involved, and a few molecules are sufficient to trigger signaling responses of a single cell. Here we report the development of far-field photostable-optical-nanoscopy (PHOTON) with photostable single-molecule-nanoparticle-optical-biosensors (SMNOBS) for mapping dynamic cascades of apoptotic signaling pathways of single live cells in real-time at single-molecule (SM) and nanometer (nm) resolutions. We have quantitatively imaged single ligand molecules (tumor necrosis factor α, TNFα) and their binding kinetics with their receptors (TNFR1) on single live cells; tracked formation and internalization of their clusters and their initiation of intracellular signaling pathways in real-time; and studied apoptotic signaling dynamics and mechanisms of single live cells with sufficient temporal and spatial resolutions. This study provides new insights into complex real-time dynamic cascades and molecular mechanisms of apoptotic signaling pathways of single live cells. PHOTON provides superior imaging and sensing capabilities and SMNOBS offer unrivaled biocompatibility and photostability, which enable probing of signaling pathways of single live cells in real-time at SM and nm resolutions. Electronic supplementary information (ESI) available. See DOI: 10.1039/c2nr11739h

Vortex information display system program description manual. [data acquisition from laser Doppler velocimeters and real time operation

NASA Technical Reports Server (NTRS)

Conway, R.; Matuck, G. N.; Roe, J. M.; Taylor, J.; Turner, A.

1975-01-01

A vortex information display system is described which provides flexible control through system-user interaction for collecting wing-tip-trailing vortex data, processing this data in real time, displaying the processed data, storing raw data on magnetic tape, and post processing raw data. The data is received from two asynchronous laser Doppler velocimeters (LDV's) and includes position, velocity, and intensity information. The raw data is written onto magnetic tape for permanent storage and is also processed in real time to locate vortices and plot their positions as a function of time. The interactive capability enables the user to make real time adjustments in processing data and provides a better definition of vortex behavior. Displaying the vortex information in real time produces a feedback capability to the LDV system operator allowing adjustments to be made in the collection of raw data. Both raw data and processing can be continually upgraded during flyby testing to improve vortex behavior studies. The post-analysis capability permits the analyst to perform in-depth studies of test data and to modify vortex behavior models to improve transport predictions.

[Analytical performances of real-time PCR by Abbott RealTime CMV with m2000 for the detection of cytomegalovirus in urine].

PubMed

De Monte, Anne; Cannavo, Isabelle; Caramella, Anne; Ollier, Laurence; Giordanengo, Valérie

2016-01-01

Congenital cytomegalovirus (CMV) infection is the leading cause of sensoneurinal disability due to infectious congenital disease. The diagnosis of congenital CMV infection is based on the search of CMV in the urine within the first two weeks of life. Viral culture of urine is the gold standard. However, the PCR is highly sensitive and faster. It is becoming an alternative choice. The objective of this study is the validation of real-time PCR by Abbott RealTime CMV with m2000 for the detection of cytomegalovirus in urine. Repeatability, reproducibility, detection limit and inter-sample contamination were evaluated. Urine samples from patients (n=141) were collected and analyzed simultaneously in culture and PCR in order to assess the correlation of these two methods. The sensitivity and specificity of PCR were also calculated. The Abbott RealTime CMV PCR in urine is an automated and sensitive method (detection limit 200 UI/mL). Fidelity is very good (standard deviation of repeatability: 0.08 to 0.15 LogUI/mL and reproducibility 0.18 LogUI/mL). We can note a good correlation between culture and Abbott RealTime CMV PCR (kappa 96%). When considering rapid culture as reference, real-time PCR was highly sensitive (100%) and specific (98.2%). The real-time PCR by Abbott RealTime CMV with m2000 is optimal for CMV detection in urine.

Real-time simulation model of the HL-20 lifting body

NASA Technical Reports Server (NTRS)

Jackson, E. Bruce; Cruz, Christopher I.; Ragsdale, W. A.

1992-01-01

A proposed manned spacecraft design, designated the HL-20, has been under investigation at Langley Research Center. Included in that investigation are flight control design and flying qualities studies utilizing a man-in-the-loop real-time simulator. This report documents the current real-time simulation model of the HL-20 lifting body vehicle, known as version 2.0, presently in use at NASA Langley Research Center. Included are data on vehicle aerodynamics, inertias, geometries, guidance and control laws, and cockpit displays and controllers. In addition, trim case and dynamic check case data is provided. The intent of this document is to provide the reader with sufficient information to develop and validate an equivalent simulation of the HL-20 for use in real-time or analytical studies.

Examining the Real-Time Effects of Reading-Strategy Training.

ERIC Educational Resources Information Center

Hamman, D.; And Others

A think-aloud protocol study examined changes in real-time cognitive, metacognitive, and motivation processing that may have resulted from reading-strategy training. Eighth-grade students participated in 4 weeks of reading-strategy training during social studies class. Students used their own social studies text during the training. Fourteen…

Validation of Aquarius Measurements Using Radiative Transfer Models at L-Band

NASA Technical Reports Server (NTRS)

Dinnat, E.; LeVine, David M.; Abraham, S.; DeMattheis, P.; Utku, C.

2012-01-01

Aquarius/SAC-D was launched in June 2011 by NASA and CONAE (Argentine space agency). Aquarius includes three L-band (1.4 GHz) radiometers dedicated to measuring sea surface salinity. We report detailed comparisons of Aquarius measurements with radiative transfer model predictions. These comparisons were used as part ofthe initial assessment of Aquarius data. In particular, they were used successfully to estimate the radiometer calibration bias and stability. Further comparisons are being performed to assess the performance of models in the retrieval algorithm for correcting the effect of sources of geophysical "noise" (e.g. the galactic background, atmospheric attenuation and reflected signal from the Sun). Such corrections are critical in bringing the error in retrieved salinity down to the required 0.2 practical salinity unit (psu) on monthly global maps at 150 km by 150 km resolution. The forward models making up the Aquarius simulator have been very useful for preparatory studies in the years leading to Aquarius' launch. The simulator includes various components to compute effects ofthe following processes on the measured signal: 1) emission from Earth surfaces (ocean, land, ice), 2) atmospheric emission and absorption, 3) emission from the Sun, Moon and celestial Sky (directly through the antenna sidelobes or after reflection/scattering at the Earth surface), 4) Faraday rotation, and 5) convolution of the scene by the antenna gain patterns. Since the Aquarius radiometers tum-on in late July 2011, the simulator has been used to perform a first order validation of the data. This included checking the order of magnitude ofthe signal over ocean, land and ice surfaces, checking the relative amplitude of signal at different polarizations, and checking the variation with incidence angle. The comparisons were also used to assess calibration bias and monitor instruments calibration drift. The simulator is also being used in the salinity retrieval. For example, initial assessments of the salinity retrieved from Aquarius data showed degradation in accuracy at locations where glint from the galactic sky background was important. This was traced to an inaccurate correction for the Sky glint. We present comparisons of the simulator prediction to the Aquarius data in order to assess the performances of the models of various physical processes impacting the measurements, such as the effect of sea surface roughness, the impact of the celestial Sky and the Sun emission scattered at the rough ocean surface. We discuss what components of the simulator appear reliable and which ones need improvements. Improved knowledge on the radiative transfer models at L-band will not only lead to better salinity retrieved from Aquarius data, it will also allow be beneficial for SMOS or the upcoming SMAP mission.

Diagnosis of invasive fungal infections using real-time PCR assay in paediatric acute leukaemia induction.

PubMed

Mandhaniya, Sushil; Iqbal, Sobuhi; Sharawat, Surender Kumar; Xess, Immaculata; Bakhshi, Sameer

2012-07-01

Invasive fungal infections (IFI) lead to morbidity and mortality in neutropenic patients and in allogenic stem cell transplantation. Serum-based fungal detection assays have limitation of specificity or sensitivity. Studies on fungal DNA detection using real-time PCR in childhood leukaemia are lacking. The aim of this study was to develop sensitive and specific diagnostic tools for IFI in paediatric acute leukaemia patients using real-time PCR. Of 100 randomised paediatric acute leukaemia patients receiving antifungal prophylaxis with voriconazole/amphotericin B, single peripheral whole blood sample in EDTA was used for Pan-AC real-time PCR assay (detects nine Candida and six Aspergillus species) in patients who failed prophylaxis due to proven, probable, possible or suspected fungal infections. PCR results were retrospectively correlated with clinical profile. Real-time PCR test was positive in 18/29 (62%) patients who failed prophylaxis. The only patient with proven IFI (mucormycosis), real-time PCR assay was negative. Real-time PCR was positive in 2/4 (50%) patients with possible and 16/24 (66.6%) suspected IFI and 5/10 (50%) patients with pneumonia. By applying method A/B, sensitivity and positive predictive value could not be commented due to unproven Aspergillus or Candida infections; specificity and negative predictive values (NPV) were 41% and 100% respectively; by method C (included episodes of possible IFI as true positive), sensitivity, specificity, PPV and NPV were 50%, 36%, 11% and 81% respectively. In those with suspected IFI, 8/24 (33.3%) were PCR negative and unnecessarily received empirical antifungal therapy (EAFT). Real-time PCR is a practical, rapid, non-invasive screening test for excluding IFI in paediatric leukaemia. The high NPV makes real-time PCR a promising tool to use this prior to initiating EAFT in antibiotic-resistant febrile neutropenic patients; this would avoid toxicity, cost and hospitalisation for EAFT (ClinicalTrials.gov identifier:NCT00624143). © 2011 Blackwell Verlag GmbH.

The diagnosis of microorganism involved in infective endocarditis (IE) by polymerase chain reaction (PCR) and real-time PCR: A systematic review.

PubMed

Faraji, Reza; Behjati-Ardakani, Mostafa; Moshtaghioun, Seyed Mohammad; Kalantar, Seyed Mehdi; Namayandeh, Seyedeh Mahdieh; Soltani, Mohammadhossien; Emami, Mahmood; Zandi, Hengameh; Firoozabadi, Ali Dehghani; Kazeminasab, Mahmood; Ahmadi, Nastaran; Sarebanhassanabadi, Mohammadtaghi

2018-02-01

Broad-range bacterial rDNA polymerase chain reaction (PCR) followed by sequencing may be identified as the etiology of infective endocarditis (IE) from surgically removed valve tissue; therefore, we reviewed the value of molecular testing in identifying organisms' DNA in the studies conducted until 2016. We searched Google Scholar, Scopus, ScienceDirect, Cochrane, PubMed, and Medline electronic databases without any time limitations up to December 2016 for English studies reporting microorganisms involved in infective endocarditis microbiology using PCR and real-time PCR. Most studies were prospective. Eleven out of 12 studies used valve tissue samples and blood cultures while only 1 study used whole blood. Also, 10 studies used the molecular method of PCR while 2 studies used real-time PCR. Most studies used 16S rDNA gene as the target gene. The bacteria were identified as the most common microorganisms involved in infective endocarditis. Streptococcus spp. and Staphylococcus spp. were, by far, the most predominant bacteria detected. In all studies, PCR and real-time PCR identified more pathogens than blood and tissue cultures; moreover, the sensitivity and specificity of PCR and real-time PCR were more than cultures in most of the studies. The highest sensitivity and specificity were 96% and 100%, respectively. The gram positive bacteria were the most frequent cause of infective endocarditis. The molecular methods enjoy a greater sensitivity compared to the conventional blood culture methods; yet, they are applicable only to the valve tissue of the patients undergoing cardiac valve surgery. Copyright © 2017. Published by Elsevier Taiwan.

Kinetic rate laws of Cd, Pb, and Zn vaporization during municipal solid waste incineration.

PubMed

Falcoz, Quentin; Gauthier, Daniel; Abanades, Stéphane; Flamant, Gilles; Patisson, Fabrice

2009-03-15

The kinetic rate laws of heavy metal (HM) vaporization from municipal solid waste during its incineration were studied. Realistic artificial waste (RAW) samples spiked with Pb, Zn, and Cd were injected into a fluidized bed reactor. Metal vaporization wastracked by continuous measure ofthe above metals in exhaust gases. An inverse model of the reactor was used to calculate the metal vaporization rates from the concentration vs time profiles in the outlet gas. For each metal, experiments were carried out at several temperatures in order to determine the kinetic parameters and to obtain specific rate laws as functions of temperature. Temperature has a strong influence on the HM vaporization dynamics, especially on the vaporization kinetics profile. This phenomenon was attributed to internal diffusion control of the HM release. Two types of kinetic rate laws were established based on temperature: a fourth- or fifth-order polynomial rate law (r(x) = k0e(-E(A)/RT)p(x)) for temperatures lower than 740 degrees C and a first-order polynomial (r(x) = k0e(-E(A)/ RT(q-q(f) for temperatures higher than 740 degrees C.

Stress Analysis and Fatigue Behaviour of PTFE-Bronze Layered Journal Bearing under Real-Time Dynamic Loading

NASA Astrophysics Data System (ADS)

Duman, M. S.; Kaplan, E.; Cuvalcı, O.

2018-01-01

The present paper is based on experimental studies and numerical simulations on the surface fatigue failure of the PTFE-bronze layered journal bearings under real-time loading. ‘Permaglide Plain Bearings P10’ type journal bearings were experimentally tested under different real time dynamic loadings by using real time journal bearing test system in our laboratory. The journal bearing consists of a PTFE-bronze layer approximately 0.32 mm thick on the steel support layer with 2.18 mm thick. Two different approaches have been considered with in experiments: (i) under real- time constant loading with varying bearing widths, (ii) under different real-time loadings at constant bearing widths. Fatigue regions, micro-crack dispersion and stress distributions occurred at the journal bearing were experimentally and theoretically investigated. The relation between fatigue region and pressure distributions were investigated by determining the circumferential pressure distribution under real-time dynamic loadings for the position of every 10° crank angles. In the theoretical part; stress and deformation distributions at the surface of the journal bearing analysed by using finite element methods to determine the relationship between stress and fatigue behaviour. As a result of this study, the maximum oil pressure and fatigue cracks were observed in the most heavily loaded regions of the bearing surface. Experimental results show that PTFE-Bronze layered journal bearings fatigue behaviour is better than the bearings include white metal alloy.

"Internet of Things" Real-Time Free Flap Monitoring.

PubMed

Kim, Sang Hun; Shin, Ho Seong; Lee, Sang Hwan

2018-01-01

Free flaps are a common treatment option for head and neck reconstruction in plastic reconstructive surgery, and monitoring of the free flap is the most important factor for flap survival. In this study, the authors performed real-time free flap monitoring based on an implanted Doppler system and "internet of things" (IoT)/wireless Wi-Fi, which is a convenient, accurate, and efficient approach for surgeons to monitor a free flap. Implanted Doppler signals were checked continuously until the patient was discharged by the surgeon and residents using their own cellular phone or personal computer. If the surgeon decided that a revision procedure or exploration was required, the authors checked the consumed time (positive signal-to-operating room time) from the first notification when the flap's status was questioned to the determination for revision surgery according to a chart review. To compare the efficacy of real-time monitoring, the authors paired the same number of free flaps performed by the same surgeon and monitored the flaps using conventional methods such as a physical examination. The total survival rate was greater in the real-time monitoring group (94.7% versus 89.5%). The average time for the real-time monitoring group was shorter than that for the conventional group (65 minutes versus 86 minutes). Based on this study, real-time free flap monitoring using IoT technology is a method that surgeon and reconstruction team can monitor simultaneously at any time in any situation.

Real-time MRI of the temporomandibular joint at 15 frames per second-A feasibility study.

PubMed

Krohn, Sebastian; Gersdorff, Nikolaus; Wassmann, Torsten; Merboldt, Klaus-Dietmar; Joseph, Arun A; Buergers, Ralf; Frahm, Jens

2016-12-01

The purpose of this study was to develop and evaluate a novel method for real-time MRI of TMJ function at high temporal resolution and with two different contrasts. Real-time MRI was based on undersampled radial fast low angle shot (FLASH) acquisitions with iterative image reconstruction by regularized nonlinear inversion. Real-time MRI movies with T1 contrast were obtained with use of a radiofrequency-spoiled FLASH sequence, while movies with T2/T1 contrast employed a gradient-refocused FLASH version. TMJ function was characterized in 40 randomly selected volunteers by sequential 20s acquisitions of both the right and left joint during voluntary opening and closing of the mouth (in a medial, central and lateral oblique sagittal section perpendicular to the long axis of the condylar head). All studies were performed on a commercial MRI system at 3T using the standard head coil, while online reconstruction was achieved with a bypass computer fully integrated into the MRI system. As a first result, real-time MRI studies of the right and left TMJ were successfully performed in all 40 subjects (80 joints) within a total examination time per subject of only 15min. Secondly, at an in-plane resolution of 0.75mm and 5mm section thickness, the achieved temporal resolution was 66.7ms per image or 15 frames per second. Thirdly, both T1-weighted and T2/T1-weighted real-time MRI movies provided information about TMJ function such as disc position, condyle mobility and disc-condyle relationship. While T1 contrast offers a better delineation of structures during rapid jaw movements, T2/T1 contrast was rated superior for characterizing the articular disc. In conclusion, the proposed real-time MRI method may become a robust and efficient tool for the clinical assessment of TMJ function. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Effect of Sequence Polymorphisms on Performance of Two Real-Time PCR Assays for Detection of Herpes Simplex Virus

PubMed Central

Stevenson, Jeffery; Hymas, Weston; Hillyard, David

2005-01-01

Herpes simplex virus (HSV) is the most common cause of acquired, sporadic encephalitis in the United States. PCR identification of HSV in spinal fluid has become the diagnostic gold standard due to its sensitivity and potential for speed, replacing other methods such as culture. We developed a real-time PCR assay to detect HSV, using a new type of hybridization probe, the Eclipse probe. In this study, we ran 323 samples (171 positives and 152 negatives) with the Eclipse real-time PCR assay and compared these results with another PCR assay using gel detection. The real-time assay agreed with our reference method for 319 out of the 323 samples tested (99%). Using two different real-time PCR platforms, we discovered that SNPs within the amplicon's probe binding region that are used to distinguish HSV-1 from HSV-2 can decrease assay sensitivity. This problem is potentially a general one for assays using fluorescent probes to detect target amplification in a real-time format. While real-time PCR can be a powerful tool in the field of infectious disease, careful sequence evaluation and clinical validation are essential in creating an effective assay. PMID:15872272

Towards the Real-Time Evaluation of Collaborative Activities: Integration of an Automatic Rater of Collaboration Quality in the Classroom from the Teacher's Perspective

ERIC Educational Resources Information Center

Chounta, Irene-Angelica; Avouris, Nikolaos

2016-01-01

This paper presents the integration of a real time evaluation method of collaboration quality in a monitoring application that supports teachers in class orchestration. The method is implemented as an automatic rater of collaboration quality and studied in a real time scenario of use. We argue that automatic and semi-automatic methods which…

Development of quantitative real-time PCR for detection and enumeration of Enterobacteriaceae.

PubMed

Takahashi, Hajime; Saito, Rumi; Miya, Satoko; Tanaka, Yuichiro; Miyamura, Natsumi; Kuda, Takashi; Kimura, Bon

2017-04-04

The family Enterobacteriaceae, members of which are widely distributed in the environment, includes many important human pathogens. In this study, a rapid real-time PCR method targeting rplP, coding for L16 protein, a component of the ribosome large subunit, was developed for enumerating Enterobacteriaceae strains, and its efficiency was evaluated using naturally contaminated food products. The rplP-targeted real-time PCR amplified Enterobacteriaceae species with Ct values of 14.0-22.8, whereas the Ct values for non-Enterobacteriaceae species were >30, indicating the specificity of this method for the Enterobacteriaceae. Using a calibration curve of Ct=-3.025 (log CFU/g)+37.35, which was calculated from individual plots of the cell numbers in different concentrations of 5 Enterobacteriaceae species, the rplP-targeted real-time PCR was applied to 51 food samples. A <1log difference between the real-time PCR and culture methods was obtained in a majority of the food samples (81.8%), with good correlation (r 2 =0.8285). This study demonstrated that the rplP-targeted real-time PCR method could detect and enumerate Enterobacteriaceae species in foods rapidly and accurately, and therefore, it can be used for the microbiological risk analysis of foods. Copyright © 2017 Elsevier B.V. All rights reserved.

Real-time electrochemical LAMP: a rational comparative study of different DNA intercalating and non-intercalating redox probes.

PubMed

Martin, Alexandra; Bouffier, Laurent; Grant, Kathryn B; Limoges, Benoît; Marchal, Damien

2016-06-20

We present a comparative study of ten redox-active probes for use in real-time electrochemical loop-mediated isothermal amplification (LAMP). Our main objectives were to establish the criteria that need to be fulfilled for minimizing some of the current limitations of the technique and to provide future guidelines in the search for ideal redox reporters. To ensure a reliable comparative study, each redox probe was tested under similar conditions using the same LAMP reaction and the same entirely automatized custom-made real-time electrochemical device (designed for electrochemically monitoring in real-time and in parallel up to 48 LAMP samples). Electrochemical melt curve analyses were recorded immediately at the end of each LAMP reaction. Our results show that there are a number of intercalating and non-intercalating redox compounds suitable for real-time electrochemical LAMP and that the best candidates are those able to intercalate strongly into ds-DNA but not too much to avoid inhibition of the LAMP reaction. The strongest intercalating redox probes were finally shown to provide higher LAMP sensitivity, speed, greater signal amplitude, and cleaner-cut DNA melting curves than the non-intercalating molecules.

Real-time compound sonography of the rotator-cuff: evaluation of artefact reduction and image definition.

PubMed

De Candia, Alessandro; Doratiotto, Stefsano; Paschina, Elio; Segatto, Enrica; Pelizzo, Francesco; Bazzocchi, Massimo

2003-04-01

The aim of this study was to compare real time compound sonography with conventional sonography in the evaluation of rotator cuff tears. A prospective study was performed on 50 supraspinatus tendons in 101 patients treated by surgical acromioplasty. The surgeon described 33 (66%) full-thickness tears and 17 (34%) partial-thickness tears. All tendons were examined by conventional sonography and real time compound sonography on the day before surgery. The techniques were compared by evaluating the images for freedom from artefacts, contrast resolution and overall image definition. Real time compound sonography proved to be superior to conventional sonography as regards freedom from artefacts in 50 cases out of 50 (100%). It was superior to conventional sonography in evaluating the image contrast resolution in 45 cases out of 50 (90%), and superior to conventional sonography in overall image definition in 45 out of 50 cases (90%). Real-time compound sonography reduces the intrinsic artefacts of conventional sonography and allows better overall image definition. In particular, the digital technique allowed us to study the rotator cuff with better contrast resolution and sharper and more detailed images than did conventional sonography.

Dynamic Beam Solutions for Real-Time Simulation and Control Development of Flexible Rockets

NASA Technical Reports Server (NTRS)

Su, Weihua; King, Cecilia K.; Clark, Scott R.; Griffin, Edwin D.; Suhey, Jeffrey D.; Wolf, Michael G.

2016-01-01

In this study, flexible rockets are structurally represented by linear beams. Both direct and indirect solutions of beam dynamic equations are sought to facilitate real-time simulation and control development for flexible rockets. The direct solution is completed by numerically integrate the beam structural dynamic equation using an explicit Newmark-based scheme, which allows for stable and fast transient solutions to the dynamics of flexile rockets. Furthermore, in the real-time operation, the bending strain of the beam is measured by fiber optical sensors (FOS) at intermittent locations along the span, while both angular velocity and translational acceleration are measured at a single point by the inertial measurement unit (IMU). Another study in this paper is to find the analytical and numerical solutions of the beam dynamics based on the limited measurement data to facilitate the real-time control development. Numerical studies demonstrate the accuracy of these real-time solutions to the beam dynamics. Such analytical and numerical solutions, when integrated with data processing and control algorithms and mechanisms, have the potential to increase launch availability by processing flight data into the flexible launch vehicle's control system.

Synchronization and fault-masking in redundant real-time systems

NASA Technical Reports Server (NTRS)

Krishna, C. M.; Shin, K. G.; Butler, R. W.

1983-01-01

A real time computer may fail because of massive component failures or not responding quickly enough to satisfy real time requirements. An increase in redundancy - a conventional means of improving reliability - can improve the former but can - in some cases - degrade the latter considerably due to the overhead associated with redundancy management, namely the time delay resulting from synchronization and voting/interactive consistency techniques. The implications of synchronization and voting/interactive consistency algorithms in N-modular clusters on reliability are considered. All these studies were carried out in the context of real time applications. As a demonstrative example, we have analyzed results from experiments conducted at the NASA Airlab on the Software Implemented Fault Tolerance (SIFT) computer. This analysis has indeed indicated that in most real time applications, it is better to employ hardware synchronization instead of software synchronization and not allow reconfiguration.

Real-time estimation of prostate tumor rotation and translation with a kV imaging system based on an iterative closest point algorithm.

PubMed

Tehrani, Joubin Nasehi; O'Brien, Ricky T; Poulsen, Per Rugaard; Keall, Paul

2013-12-07

Previous studies have shown that during cancer radiotherapy a small translation or rotation of the tumor can lead to errors in dose delivery. Current best practice in radiotherapy accounts for tumor translations, but is unable to address rotation due to a lack of a reliable real-time estimate. We have developed a method based on the iterative closest point (ICP) algorithm that can compute rotation from kilovoltage x-ray images acquired during radiation treatment delivery. A total of 11 748 kilovoltage (kV) images acquired from ten patients (one fraction for each patient) were used to evaluate our tumor rotation algorithm. For each kV image, the three dimensional coordinates of three fiducial markers inside the prostate were calculated. The three dimensional coordinates were used as input to the ICP algorithm to calculate the real-time tumor rotation and translation around three axes. The results show that the root mean square error was improved for real-time calculation of tumor displacement from a mean of 0.97 mm with the stand alone translation to a mean of 0.16 mm by adding real-time rotation and translation displacement with the ICP algorithm. The standard deviation (SD) of rotation for the ten patients was 2.3°, 0.89° and 0.72° for rotation around the right-left (RL), anterior-posterior (AP) and superior-inferior (SI) directions respectively. The correlation between all six degrees of freedom showed that the highest correlation belonged to the AP and SI translation with a correlation of 0.67. The second highest correlation in our study was between the rotation around RL and rotation around AP, with a correlation of -0.33. Our real-time algorithm for calculation of rotation also confirms previous studies that have shown the maximum SD belongs to AP translation and rotation around RL. ICP is a reliable and fast algorithm for estimating real-time tumor rotation which could create a pathway to investigational clinical treatment studies requiring real-time measurement and adaptation to tumor rotation.

Real-time estimation of prostate tumor rotation and translation with a kV imaging system based on an iterative closest point algorithm

NASA Astrophysics Data System (ADS)

Nasehi Tehrani, Joubin; O'Brien, Ricky T.; Rugaard Poulsen, Per; Keall, Paul

2013-12-01

Previous studies have shown that during cancer radiotherapy a small translation or rotation of the tumor can lead to errors in dose delivery. Current best practice in radiotherapy accounts for tumor translations, but is unable to address rotation due to a lack of a reliable real-time estimate. We have developed a method based on the iterative closest point (ICP) algorithm that can compute rotation from kilovoltage x-ray images acquired during radiation treatment delivery. A total of 11 748 kilovoltage (kV) images acquired from ten patients (one fraction for each patient) were used to evaluate our tumor rotation algorithm. For each kV image, the three dimensional coordinates of three fiducial markers inside the prostate were calculated. The three dimensional coordinates were used as input to the ICP algorithm to calculate the real-time tumor rotation and translation around three axes. The results show that the root mean square error was improved for real-time calculation of tumor displacement from a mean of 0.97 mm with the stand alone translation to a mean of 0.16 mm by adding real-time rotation and translation displacement with the ICP algorithm. The standard deviation (SD) of rotation for the ten patients was 2.3°, 0.89° and 0.72° for rotation around the right-left (RL), anterior-posterior (AP) and superior-inferior (SI) directions respectively. The correlation between all six degrees of freedom showed that the highest correlation belonged to the AP and SI translation with a correlation of 0.67. The second highest correlation in our study was between the rotation around RL and rotation around AP, with a correlation of -0.33. Our real-time algorithm for calculation of rotation also confirms previous studies that have shown the maximum SD belongs to AP translation and rotation around RL. ICP is a reliable and fast algorithm for estimating real-time tumor rotation which could create a pathway to investigational clinical treatment studies requiring real-time measurement and adaptation to tumor rotation.

Quantitative analysis of aortic regurgitation: real-time 3-dimensional and 2-dimensional color Doppler echocardiographic method--a clinical and a chronic animal study

NASA Technical Reports Server (NTRS)

Shiota, Takahiro; Jones, Michael; Tsujino, Hiroyuki; Qin, Jian Xin; Zetts, Arthur D.; Greenberg, Neil L.; Cardon, Lisa A.; Panza, Julio A.; Thomas, James D.

2002-01-01

BACKGROUND: For evaluating patients with aortic regurgitation (AR), regurgitant volumes, left ventricular (LV) stroke volumes (SV), and absolute LV volumes are valuable indices. AIM: The aim of this study was to validate the combination of real-time 3-dimensional echocardiography (3DE) and semiautomated digital color Doppler cardiac flow measurement (ACM) for quantifying absolute LV volumes, LVSV, and AR volumes using an animal model of chronic AR and to investigate its clinical applicability. METHODS: In 8 sheep, a total of 26 hemodynamic states were obtained pharmacologically 20 weeks after the aortic valve noncoronary (n = 4) or right coronary (n = 4) leaflet was incised to produce AR. Reference standard LVSV and AR volume were determined using the electromagnetic flow method (EM). Simultaneous epicardial real-time 3DE studies were performed to obtain LV end-diastolic volumes (LVEDV), end-systolic volumes (LVESV), and LVSV by subtracting LVESV from LVEDV. Simultaneous ACM was performed to obtain LVSV and transmitral flows; AR volume was calculated by subtracting transmitral flow volume from LVSV. In a total of 19 patients with AR, real-time 3DE and ACM were used to obtain LVSVs and these were compared with each other. RESULTS: A strong relationship was found between LVSV derived from EM and those from the real-time 3DE (r = 0.93, P <.001, mean difference (3D - EM) = -1.0 +/- 9.8 mL). A good relationship between LVSV and AR volumes derived from EM and those by ACM was found (r = 0.88, P <.001). A good relationship between LVSV derived from real-time 3DE and that from ACM was observed (r = 0.73, P <.01, mean difference = 2.5 +/- 7.9 mL). In patients, a good relationship between LVSV obtained by real-time 3DE and ACM was found (r = 0.90, P <.001, mean difference = 0.6 +/- 9.8 mL). CONCLUSION: The combination of ACM and real-time 3DE for quantifying LV volumes, LVSV, and AR volumes was validated by the chronic animal study and was shown to be clinically applicable.

Real-Time Systems

DTIC Science & Technology

1992-02-01

Postgraduate School Autonomous Under Vehicle (AUV) are then examined. Autonomous underwater vehicle (AUV), hard real-time system, real - time operating system , real-time programming language, real-time system, soft real-time system.

RFID-based information visibility for hospital operations: exploring its positive effects using discrete event simulation.

PubMed

Asamoah, Daniel A; Sharda, Ramesh; Rude, Howard N; Doran, Derek

2016-10-12

Long queues and wait times often occur at hospitals and affect smooth delivery of health services. To improve hospital operations, prior studies have developed scheduling techniques to minimize patient wait times. However, these studies lack in demonstrating how such techniques respond to real-time information needs of hospitals and efficiently manage wait times. This article presents a multi-method study on the positive impact of providing real-time scheduling information to patients using the RFID technology. Using a simulation methodology, we present a generic scenario, which can be mapped to real-life situations, where patients can select the order of laboratory services. The study shows that information visibility offered by RFID technology results in decreased wait times and improves resource utilization. We also discuss the applicability of the results based on field interviews granted by hospital clinicians and administrators on the perceived barriers and benefits of an RFID system.

Holographic Lens for Pilot’s Head-Up Display

DTIC Science & Technology

1976-02-01

holog; rdm lens. The dynamically-stabilized recording apparatus for the full- scale transmission hologram lens was designed and assembled in Phase 2...8217LjI for which the fringe visibility measured is 0.707 ........... 25 3 Coherence lengjth for TEMQ is 3.5 cm........27 4 Masured sinkile frequency...horizontal focal surfaces ofthe T90-N8-21.9 hologram lens . . . . . . . 118 41 Chief ray efficiency measured as a function of vertical and horizontal field

Issues of Commonality. Volume II. Issue Analysis.

DTIC Science & Technology

1980-12-01

lubricating oil, and residual oil. 68 ° B Diesel fuel and kerosene make up what are known as the middle distillates. Jet fuels are blends from this...group of distillates which include some gasoline and some heavier oils. The range of hydrocarbons selected for this blending determines the "cut" of...the fuel. Wide-cut fuels are blended fram a wide range of hydrocarbons; narrow-cut fuels include only a small range of hydrocarbons from the

The Bosnian Train and Equip Program: A Lesson in Interagency Integration of Hard and Soft Power

DTIC Science & Technology

2014-03-01

first week of January, 1996. In Zagreb , the Croatians were cautiously supportive on the condition that the program would be administered through the...and rail. That required support from Croatian officials in Zagreb to use the Croatian port of Ploce, which controlled the most efficient means of...the major impediment to passing the Defense Law and appealed to authorities in Zagreb to encourage their cooperation.199 Yet they also thought the

An Evaluation of Liquid and Two-Phase Cooling Techniques for Use in Electrical Machinery.

DTIC Science & Technology

1984-12-01

equations (3.5) & (3.6) k Thermal conductivity L Condenser length m Mass flow rate b Nu Nusselt number P Pressure Pr Prandtl number Q Heat-transfer rate...IRI finned condenser (with axially-straight or helical fins), or 4. use an internally-grooved condenser . Marto [17] presents a detailed discussion of...the appropriate models for the first two cases. For example, for rotating truncated-cone condensers , Ballback [28] performed a Nusselt -type analysis

Performance Analysis of the United States Marine Corps War Reserve Materiel Program Process Flow

DTIC Science & Technology

2016-12-01

or Less)............41 Figure 21. Tornado Diagram of Expected Delays Using 2016 Inputs ........................42 x Figure 22. Fishbone Diagram of...variability. Using Crystal Ball we produced a Tornado Diagram (similar to a Pareto Chart) in order to tell us where to focus our efforts. The results of...the Tornado Diagram are shown in Figure 21. Figure 21. Tornado Diagram of Expected Delays Using 2016 Inputs Using the results shown in the Tornado

An Analysis Of The Benefits And Application Of Earned Value Management (EVM) Project Management Techniques For Dod Programs That Do Not Meet Dod Policy Thresholds

DTIC Science & Technology

2017-12-01

carefully to ensure only minimum information needed for effective management control is requested.  Requires cost-benefit analysis and PM...baseline offers metrics that highlights performance treads and program variances. This information provides Program Managers and higher levels of...The existing training philosophy is effective only if the managers using the information have well trained and experienced personnel that can

Open-Water Resistance and Seakeeping Characteristics of Ships with Icebreaking Bows

DTIC Science & Technology

1991-05-13

of a Knuckled Forefoot on a Typical Icebreaker ...... ................... . 19 3-2. Lines Plan, T-AGS OCEAN (ICE) . * * .... . 23 3-3. Curve of...the ice. As the stem strikes the ice, initial failure of the ice occurs by simple crushing. Then the raked stem of the icebreaker rides up onto the ice...bossings, skegs, rudders, 18 and special stem forefoot shapes were not included in the shapes tested. To ensure that the parent and its variants

Collective Protection (ColPro) Field Testing

DTIC Science & Technology

2011-09-28

It is recommended that methyl salicylate (MeS) or similar simulants that are not difficult to decontaminate should be used for this purpose. 4.4.3...ce nt ra tio n (m g/ m 3 ) Figure 3. Analysis of ppbRAE® and Solid Sorbent Tube (SST) Data, Methyl Salicylate (MeS) Challenge to the Interior of...the Vehicle. Figure 4. Gasmet™ Analysis of the Methyl Salicylate (MeS) Challenge in the Simulant- Exposure Area (SEA). TOP 08-2-198 28 September

Projective Structure from Two Uncalibrated Images: Structure from Motion and Recognition

DTIC Science & Technology

1992-09-01

correspondence between points in Maybank 1990). The question, therefore, is why look for both views more of a problem, and hence, may make the...plane is fixed with respect to the 1987, Faugeras, Luong and Maybank 1992). The prob- camera coordinate frame. A rigid camera motion, there- lem of...the second reference Rieger-Lawton 1985, Faugeras and Maybank 1990, Hil- plane (assuming the four object points Pi, j = 1, ...,4, dreth 1991, Faugeras

Does a Personalized Health Portal for Diabetes Retinal Imaging Positively Affect Motivational Readiness to Change

DTIC Science & Technology

2012-02-01

at 3.4%; and 3) statewide, the prevalence of retinopathy among adults with type 2 diabetes is 22%, with Native Hawaiians having the highest...which affects both type 1 and type 2 diabetic patients, includes diabetic retinopathy (DR), cataracts and glaucoma. The most common occurrence of...the three is diabetic retinopathy , which affects 40–45% of all those diagnosed with diabetes . There are four stages of DR: mild, moderate, severe

Rethinking the National Interest: Putin’s Turn in Russian Foreign Policy

DTIC Science & Technology

2008-01-01

the United States, Britain, Russia, France and Germany, but also those of key institutions such as the United Nations, European Union and NATO. One of...the Germans say; “no bourgeoisie , no democracy,” as put by Barrington Moore. The overwhelming role of the state in Russian history had effectively... France by the Algerian War or on the United States by the Vietnam War. Political dissidence was limited to small intellectual circles, as respected as

Near East/South Asia Report.

DTIC Science & Technology

1986-02-11

equipment such as modern artificial kidney systems, modern equipment related to the treatment of cancer by ra- diation, the purchase of ambulances and the...DAGBLADET and Arne Lemberg of EXPRESSEN died in April 1979. They took a boat from Kenya to the Ugandan village of Katosi with the intention of...the act. He came to London last Sunday after having been released the week before from prison in Uganda. After Amin’s fall, he fled to Kenya , only a few

Moral Support, Strategic Reasoning, or Domestic Politics: America’s Continual Support to Israel

DTIC Science & Technology

2007-12-01

were enhanced by key events to include the Eichmann trial, the Six-Day War, and popular cultural influences, which contributed to the remembrance of...the Holocaust and support for Israel.46 The Eichmann trail was one event that undoubtedly produced a growing awareness of the Holocaust memory for...not only America but the world as well. Although the facts of the Holocaust were always available to the public, the Eichmann trail reiterated

IERS Conventions (2003)

DTIC Science & Technology

2004-01-01

International Earth Rotation and Reference Systems Service (IERS) Service International de la Rotation Terrestre et des Systèmes de Référence IERS...Equation for the determination of the density of moist air (1981/91),” Metrologia , 29, pp. 67–70. Giacomo, P., 1982, “Equation for the determination of...the density of moist air (1981),” Metrologia , 18, pp. 33–40. Herring, T. A., 1992, “Modeling Atmospheric Delays in the Analysis of Space Geodetic Data

The Perception of the Higher Derivatives of Visual Motion.

DTIC Science & Technology

1986-06-24

uniform velocity in one run with a target mov- ing with either an accelerating or decelerating motion on another run , and had to decide on which of...the two runs the motion was uniform. It was found that sensitivity to acceleration (as indicated by proportion of correct dis- criminations) decreased...20 subjects had 8 In an experiment by Runeson (1975), one target (the stan- tracking runs with each of the three tvpes of moving target. The third

Acceleration Strain Transducer

DTIC Science & Technology

2007-11-05

accelerometer 10 includes a fiber laser 12. Fiber laser 12 can be either a Fabry - Perot type cavity fiber laser or a distributed feedback fiber laser. In a... Fabry - Perot type fiber laser, the laser cavity is a length of erbium- doped optical fiber with a Bragg grating written in the fiber core at either end of...the phase shifted signal. Receiver 26 is capable of demodulating and detecting the signal from the fiber laser by various methods well known in the

Methodology to Model and Understand the Complexities of Social, Economic,and Governance Interactions for Regional Assessment in Kenya

DTIC Science & Technology

2012-07-01

factors, including its declining tourism -based economy and its predominantly non-Muslim population surrounded by many predominantly Muslim countries...natural resources such as tea, coffee, wheat, sugarcane, fruit, dairy products, and meats. However, it is tourism that results in a large percentage of...the annual income for Kenya, and with the increasing level of corruption and violence, tourism has begun to decrease as foreigners choose to not visit

Light Weapons and Intrastate Conflict, Early Warning Factors and Preventive Action. A Report to the Carnegie Commission on Preventing Deadly Conflict,

DTIC Science & Technology

1998-07-01

x. BACKGROUND , RECENT EXPERIENCE, AND THE BEGINNINGS 13 OF INTERNATIONAL ACTION Background , 13 Codifying and Illustrating the Experience to Date...are proposed for preventive action at the national, regional, and international level. BACKGROUND , RECENT EXPERIENCE, AND THE BEGINNINGS OF...the nature of such conflict, and most important, the types and modes of acquisition of the weapons now used in this type of conflict. BACKGROUND

New Fluorinated and Sulfonated Block Copolymers Final Report

DTIC Science & Technology

2009-04-23

use polymers namely, Polymer Electrolyte Membrane Fuel Cells ( PEMFC ) and Direct Methanol Fuel Cells (DMFC) The DMFC can be seen as a variant of...the PEMFC . The membranes are typically the same; however, the feed for DMFC is methanol in an aqueous 1-2 M solution or in its vapor form. This fuel...the existing liquid fuels infrastructure can be used for methanol. Catalysts, as well as operating temperature ranges, are very similar to the PEMFC

Pharmacologic and Nonpharmacologic Approaches to the Treatment of Hypertension with Implications for the Clinical Nurse Specialist

DTIC Science & Technology

1988-01-01

Hypertension 6 14 that assist in regulation of smooth muscle contraction . This results in a lowered peripheral vascular resistance and 6 thus, a lowering of...the effect of epinephrine and also allows the sustained vascular smooth - muscle contraction caused by the catecholamines; this too, contributing to an...hypertension. These agents cause arteriolar dilatation by acting directly on vascular smooth muscle . They do this by interfering with the calcium gates

Splitting of the Proximal Femur With a New Femoral Nail

DTIC Science & Technology

2010-04-01

should be exercised with the use of new implants that require a change in customary technique. In addition, some concern must be raised by the amount of...the potential for gluteus medius tendon injury,8 whereas other authors have found greater soft-tissue injury by inserting a nail through the...Entry Femoral Nail (Synthes USA, Paoli, PA) moved the entry point further lateral (10 degrees) and distal to completely avoid the gluteus medius tendon

WELDED JACKETED URANIUM BODY

DOEpatents

Gurinsky, D.H.

1958-08-26

A fuel element is presented for a neutronic reactor and is comprised of a uranium body, a non-fissionable jacket surrounding sald body, thu jacket including a portion sealed by a weld, and an inclusion in said sealed jacket at said weld of a fiux having a low neutron capture cross-section. The flux is provided by combining chlorine gas and hydrogen in the intense heat of-the arc, in a "Heliarc" welding muthod, to form dry hydrochloric acid gas.

Supplemental Environmental Assessment & Finding of No Significant Impact: Louisville Bend State Wildlife Area Fish and Wildlife Habitat Rehabilitation

DTIC Science & Technology

2013-05-01

and Maintenance of the Missouri River Bank Stabilization and Navigation Project, and Operation of the Kansas River Reservoir System, and acquiring and...developing lands to produce habitat as directed by the BSNP Mitigation Project. The proposed project would be constructed under the authority of...the Mitigation Project. The Missouri River BSNP Mitigation Project of Missouri, Kansas , Iowa, and Nebraska was authorized by Section 601 (a) of the

Al-Shabaab: The Threat to Kenya and the Horn of Africa

DTIC Science & Technology

2013-03-01

Transitional Federal Government as well as the African Union (AU) peace keeping force, the African Mission in Somalia (AMISOM). Al Shabaab began as part of...the armed wing of the Islamic Courts Union (ICU) when the Courts Union gained power in the Somali capital of Mogadishu in 2006, then the Ethiopian...Somalia The Somalia Republic gained independence on 1st July 1960 formed by the Union of British Somaliland and Italian Somaliland with Aden Abdullah

Biologically-Inspired Micro-Robots. Volume 1. Robots Based on Crickets

DTIC Science & Technology

2005-05-19

is limited to flat, smooth surfaces. Another group of specialized robots that use piezoelectric actuators are the pipe robots developed at Shanghai...along in a pipe . They were developed for very specific terrain that allows them to take advantage of the small strain, high- frequency motion of...the valve. To open the valve you apply a current to the TiNi, heating it and pulling the plunger up, opening the valve. All three components are

Using Human Patient Simulation to Improve Emergency Airway Management Safety in Post Anesthesia Nursing: A Pilot Project

DTIC Science & Technology

2010-08-04

airway management practices in the PACU has been deemed successful by KMC anesthesia management 15. SUBJECT TERMS Human Patient Simulation; Emergency...of South Alabama and KMC Clinical Research Laboratory (CRL) were received. The training sessions were planned for two 4-hour sessions in the HPS...assistance ofthe KMC CRL research statistician. Findings Results of the NLN Simulation Design Scale surveys showed seven of eight nurses in the

ABSOLUTE BUNCH LENGTH MEASUREMENTS AT THE ALS BY INCOHERENTSYNCHROTRON RADIATION FLUCTUATION ANALYSIS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sannibale, Fernando; Zolotorev, Max S.; Filippetto, Daniele

2007-06-22

By analysing the pulse to pulse intensity fluctuations ofthe radiation emitted by a charge particle in the incoherent part of thespectrum, it is possible to extract information about the spatialdistribution of the beam. At the Advanced Light Source (ALS) of theLawrence Berkeley National Laboratory, we have developed and tested asimple scheme based on this principle that allows for the absolutemeasurement of the bunch length. A description of the method and theexperimental results are presented.

A New Paradigm for African American Breast Cancer Involving Stem Cell Differentiation in a Novel Cell Culture System

DTIC Science & Technology

2006-10-01

hereditary xeroderma pigmentosum (XP) [19], a disease with a 1200-fold increase in incidence of skin cancer [20]. The signal for activation of the NER...repair replication of DNA in xeroderma pigmentosum . Nature 1968, 218:652-656. 20. Luddy RE, Sweren RJ: Skin cancer. In Malignant Diseases of...the DNA repair defective genodermatoses xeroderma pigmentosum , Cockayne’s syndrome, and trichothiodystrophy. J Invest Dermatol 1990, 94:94-100. 41

Concept of Operations for the Establishment of the Joint Pathology Center

DTIC Science & Technology

2008-12-19

the Joint Task Force National Capital Region Medical (JTF CapMed ) in collaboration with the Uniformed Services University of Health Sciences (USUHS...Medical Examiner (OAFME). The Board deems the identification of appropriate support for the OAFME as critical , since with the disestablishment of...the DoD. The establishment of the JPC within JTF CapMed is a logical choice to the extent that JTF Cap Med is a joint medical organization and can

Micromechanisms of Monotonic and Cyclic Subcritical Crack Growth in Advanced High Melting Point Low-Ductility Intermetallics

DTIC Science & Technology

1991-05-01

next generation of hk,- s-performance jet engines will require markedly stiffer materials, operating at higher stress levels anw. :apable of...the crack tip, and fatigue-crack propagation is observed at stress -intensity levels as low as 6 MPa&m, far below those required to initiate cracking...The next generation of high-performance jet engines will require markedly stiffer materials, operating at higher stress levels and capable of

JPRS Report, East Asia, Southeast Asia.

DTIC Science & Technology

1991-04-26

at Nurul Iman Palace between Minister of Defense Datuk Sri Najib Tun Razak and Sultan of Brunei Hassanal Bolkiah. Datuk Sri Najib was on a one-day...Haji Apong. Speaking to reporters at the Brunei International Airport before returning to Kuala Lumpur, Datuk Sri Najib said that the sultan of...the MOU so that it can be signed quickly," Datuk Sri Najib said. He said the main provisions of the MOU will include officer training, acquisition of

Setup: What the Air Force Did in Vietnam and Why

DTIC Science & Technology

1991-06-01

4, no. 2 (Fall 1950) : 12 . 18 . Ibid . 19 . Giulio Douhet, The Command ofthe Air, trans . Dino Ferrari, reprinted by the Office of Air Force History...demilitarized zone (DMZ). Ironically, in November 1954, Gen Tran Van Don and other leading Vietnamese generals suggested that the MAAG organize their...Office ofAir Force History, 1981), 36. 37 . Ibid., 49-50. 38 . According to formerSouth Vietnamese minister ofnational defense Gen Tran Van Don, he and

The Role of Combat Heavy Engineer Battalions in Nation Assistance.

DTIC Science & Technology

1991-06-07

project can be built, it must first be designed and planned. Someone must assess what the user needs and provide a set of specifications, blueprints, and...the soldiers 65 of both Niger and the United States grew to respect and appreciate each other.1 9 Still much can be learned from the number of...the lessons learned from these projects to assess when combat heavy battalions can be most effectively used for nation assistance. 96 ENDNOTES

Expansion or Marginalization: How Effects-Based Organization Could Determine the Future of Air Force Space Command

DTIC Science & Technology

2008-07-01

should be split on kinetic/nonkinetic lines.5 Such a division appears to be artificial —a red herring. Whether the enemy is destroyed with bombs...tactical point of view, the artificial distinction between endo- and exo-atmospheric regimes disappears when warriors can maneuver in and out of...the next several decades, instead of segregating space assets through an artificial domain distinction, the greater good is better served by

A Parametric Model for Large Scale Agent Systems

DTIC Science & Technology

2005-04-01

what are the critical parameters that it depends on? We have argued in a companion paper (also in this vol- ume) that the common prescriptions of...the companion paper immediately preced- ing this paper. 241 3 An Application A collection of Unmanned Aerial Vehicles (UAVs) on a multi-task mission...Narciso Mart́ı-Oliet Dpto. de Sistemas Informáticos y Programación Universidad Complutense de Madrid, Spain narciso@sip.ucm.es Abstract We describe

Does the Army Need a Homeland Security Skill Identifier?

DTIC Science & Technology

2011-06-10

MOS is represented in the fourth character of the warrant officer MOSC . The use of a skill qualification identifier (SQI) in the fifth character of...the MOSC creates another MOS that carries the title of the SQI. (Department of the Army 2009a, 50) Multiple Skill Position (officers). A position...training. The SQI is represented in the fifth character of the warrant officer MOSC and may be used to represent functional career tracks with an

Report on Survey Implementation. Research Triangle Institute, Caliber Associates and Human Resources Research Organization

DTIC Science & Technology

1994-03-01

DISTRIBUTION /AVAILABILITY STATEMENT 12b. DISTRIBUTION CODE Approved for public release; distribution is unlimited. 13. ABSTRACT ( Maximum 200 words) This...different factors influence degree of readiness. The Army currently does not have an operational set of reliable, comprehensive, and valid measures of...the p.ro . . ....iky th .. ... - ou... ,,,,,,,uni.,.,ucceaa I&Ar COm.FI.,,, AIO W.Wa .’,U.J M-SS-oU, (b) the variable would be a valid indicator of

Low-Intensity Conflict in the Third World

DTIC Science & Technology

1988-08-01

destiny long before the coming of Nasir. By the last decades of the nineteenth century, a new generation of Islamic thinkers had appeared in Egypt. They...In al-Banna’s movement, then, there existed the embryo of a new Islamic social order that faithfully replicated an older Islamic experience solidly...Islam’s relation to modernism, Egypt’s Arab destiny , and the right to determine the course ofthe pan-Arab polity. The competition was prolonged well into

Electrofluidic systems for contrast management

NASA Astrophysics Data System (ADS)

Rebello, Keith J.; Maranchi, Jeffrey P.; Tiffany, Jason E.; Brown, Christopher Y.; Maisano, Adam J.; Hagedon, Matthew A.; Heikenfeld, Jason C.

2012-06-01

Operating in dynamic lighting conditions and in greatly varying backgrounds is challenging. Current paints and state-ofthe- art passive adaptive coatings (e.g. photochromics) are not suitable for multi- environment situations. A semi-active, low power, skin is needed that can adapt its reflective properties based on the background environment to minimize contrast through the development and incorporation of suitable pigment materials. Electrofluidic skins are a reflective display technology for electronic ink and paper applications. The technology is similar to that in E Ink but makes use of MEMS based microfluidic structures, instead of simple black and white ink microcapsules dispersed in clear oil. Electrofluidic skin's low power operation and fast switching speeds (~20 ms) are an improvement over current state-ofthe- art contrast management technologies. We report on a microfluidic display which utilizes diffuse pigment dispersion inks to change the contrast of the underlying substrate from 5.8% to 100%. Voltage is applied and an electromechanical pressure is used to pull a pigment dispersion based ink from a hydrophobic coated reservoir into a hydrophobic coated surface channel. When no voltage is applied, the Young-Laplace pressure pushes the pigment dispersion ink back down into the reservoir. This allows the pixel to switch from the on and off state by balancing the two pressures. Taking a systems engineering approach from the beginning of development has enabled the technology to be integrated into larger systems.

Supporting Fourth Graders' Ability to Interpret Graphs through Real-Time Graphing Technology: A Preliminary Study

ERIC Educational Resources Information Center

Deniz, Hasan; Dulger, Mehmet F.

2012-01-01

This study examined to what extent inquiry-based instruction supported with real-time graphing technology improves fourth grader's ability to interpret graphs as representations of physical science concepts such as motion and temperature. This study also examined whether there is any difference between inquiry-based instruction supported with…

Development of real-time PCR technique for the estimation of population density of Pythium intermedium in forest soils.

PubMed

Li, Mingzhu; Senda, Masako; Komatsu, Tsutomu; Suga, Haruhisa; Kageyama, Koji

2010-10-20

Pythium intermedium is known to play an important role in the carbon cycling of cool-temperate forest soils. In this study, a fast, precise and effective real-time PCR technique for estimating the population densities of P. intermedium from soils was developed using species-specific primers. Specificity was confirmed both with conventional PCR and real-time PCR. The detection limit (sensitivity) was determined and amplification standard curves were generated using SYBR Green II fluorescent dye. A rapid and accurate assay for quantification of P. intermedium in Takayama forest soils of Japan was developed using a combination of a new DNA extraction method and PCR primers were developed for real-time PCR. And the distribution of P. intermedium in forest soil was investigated with both soil plating method and the developed real-time PCR technique. This new technique will be a useful tool and can be applied to practical use for studying the role of Pythium species in forest and agricultural ecosystems. Copyright © 2009 Elsevier GmbH. All rights reserved.

Impact of real-time notification of Clostridium difficile test results and early initiation of effective antimicrobial therapy.

PubMed

Polen, Christian B; Judd, William R; Ratliff, Patrick D; King, Gregory S

2018-05-01

Clostridium difficile is a prominent nosocomial pathogen and is the most common causative organism of health care-associated diarrhea. To our knowledge, no studies have investigated the impact of real-time notification of culture results with rapid antimicrobial stewardship program (ASP) intervention in the setting of C difficile infection (CDI). The purpose of this study was to assess the impact of real-time notification of detection of toxigenic C difficile by DNA amplification results in patients with confirmed CDI. This is a single-center, retrospective cohort study at a 433-bed tertiary medical center in central Kentucky. The study consisted of 2 arms: patients treated for CDI prior to implementation of real-time provider notification and patients postimplementation. The primary outcome was time to initiation of effective antimicrobial therapy. The median time to initiation of effective antimicrobial therapy decreased from 5.75 hours in the preimplementation cohort to 2.05 hours in the postimplementation cohort (P = .001). ASP intervention also resulted in a shorter time from detection of CDI to order entry of effective antimicrobial therapy in the patient's electronic medical record (3.0 vs 0.6 hours; P = .001). The implementation of a real-time notification system to alert a pharmacist-led ASP of toxigenic CDI resulted in statistically significant shorter times to order entry and subsequent initiation of effective antimicrobial therapy and contact precautions. Copyright © 2018 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

Care Reasoning in Real-Life Moral Conflicts

ERIC Educational Resources Information Center

Juujarvi, Soile

2006-01-01

This article examines real-life moral conflicts from the perspective of the ethic of care. Fifty-six (Time 1) and 57 (Time 2) real-life dilemmas provided by students representing different fields of study were analysed in terms of level of care reasoning according to Skoe's Ethic of Care Interview. The results showed that antisocial temptation and…

Correcting satellite-based precipitation products through SMOS soil moisture data assimilation in two land-surface models of different complexity: API and SURFEX

USDA-ARS?s Scientific Manuscript database

Real-time rainfall accumulation estimates at the global scale is useful for many applications. However, the real-time versions of satellite-based rainfall products are known to contain errors relative to real rainfall observed in situ. Recent studies have demonstrated how information about rainfall ...

Conducting Real-Time Videofluoroscopic Swallow Study via Telepractice: A Preliminary Feasibility and Reliability Study.

PubMed

Burns, Clare L; Ward, Elizabeth C; Hill, Anne J; Phillips, Nick; Porter, Linda

2016-06-01

A small number of studies have examined the feasibility of conducting videofluoroscopic swallow studies (VFSS) via telepractice. While the results have confirmed this potential, the systems tested to date have either reported issues that impacted the ability to analyze/interpret the VFSS recordings in real time, or they were not designed to enable real-time interpretation. Further system design is needed to establish a telepractice model that enables the VFSS assessment to be both guided and interpreted live in real time. The aim of this study was to test the feasibility and reliability of using a telepractice system to enable live VFSS assessment. Twenty adult patients underwent a VFSS assessment directed by a telepractice SLP with competency in VFSS located in another room of the hospital. The telepractice clinician led the sessions using a C20 Cisco TelePresence System. This was linked in real time via a secure telehealth network (at 4 megabits per second (Mbit/s)) to a C60 Cisco TelePresence System located in a fluoroscopy suite, connected to the digital fluoroscopy system. Levels of agreement were calculated between the telepractice clinician and a face-to-face clinician who simultaneously rated the VFSS in real time. High levels of agreement for swallowing parameters (range = 75-100 %; k = -0.34 to 1.0) and management decisions (range = 70-100 %, k = 0.64-1.0) were found. A post-session questionnaire revealed clinicians agreed that the telepractice system enabled successful remote assessment of VFSS. The findings support the potential to conduct live VFSS assessment via a telepractice model.

Real-time volcano monitoring using GNSS single-frequency receivers

NASA Astrophysics Data System (ADS)

Lee, Seung-Woo; Yun, Sung-Hyo; Kim, Do Hyeong; Lee, Dukkee; Lee, Young J.; Schutz, Bob E.

2015-12-01

We present a real-time volcano monitoring strategy that uses the Global Navigation Satellite System (GNSS), and we examine the performance of the strategy by processing simulated and real data and comparing the results with published solutions. The cost of implementing the strategy is reduced greatly by using single-frequency GNSS receivers except for one dual-frequency receiver that serves as a base receiver. Positions of the single-frequency receivers are computed relative to the base receiver on an epoch-by-epoch basis using the high-rate double-difference (DD) GNSS technique, while the position of the base station is fixed to the values obtained with a deferred-time precise point positioning technique and updated on a regular basis. Since the performance of the single-frequency high-rate DD technique depends on the conditions of the ionosphere over the monitoring area, the ionospheric total electron content is monitored using the dual-frequency data from the base receiver. The surface deformation obtained with the high-rate DD technique is eventually processed by a real-time inversion filter based on the Mogi point source model. The performance of the real-time volcano monitoring strategy is assessed through a set of tests and case studies, in which the data recorded during the 2007 eruption of Kilauea and the 2005 eruption of Augustine are processed in a simulated real-time mode. The case studies show that the displacement time series obtained with the strategy seem to agree with those obtained with deferred-time, dual-frequency approaches at the level of 10-15 mm. Differences in the estimated volume change of the Mogi source between the real-time inversion filter and previously reported works were in the range of 11 to 13% of the maximum volume changes of the cases examined.

Simultaneous real-time monitoring of multiple cortical systems.

PubMed

Gupta, Disha; Jeremy Hill, N; Brunner, Peter; Gunduz, Aysegul; Ritaccio, Anthony L; Schalk, Gerwin

2014-10-01

Real-time monitoring of the brain is potentially valuable for performance monitoring, communication, training or rehabilitation. In natural situations, the brain performs a complex mix of various sensory, motor or cognitive functions. Thus, real-time brain monitoring would be most valuable if (a) it could decode information from multiple brain systems simultaneously, and (b) this decoding of each brain system were robust to variations in the activity of other (unrelated) brain systems. Previous studies showed that it is possible to decode some information from different brain systems in retrospect and/or in isolation. In our study, we set out to determine whether it is possible to simultaneously decode important information about a user from different brain systems in real time, and to evaluate the impact of concurrent activity in different brain systems on decoding performance. We study these questions using electrocorticographic signals recorded in humans. We first document procedures for generating stable decoding models given little training data, and then report their use for offline and for real-time decoding from 12 subjects (six for offline parameter optimization, six for online experimentation). The subjects engage in tasks that involve movement intention, movement execution and auditory functions, separately, and then simultaneously. Main Results: Our real-time results demonstrate that our system can identify intention and movement periods in single trials with an accuracy of 80.4% and 86.8%, respectively (where 50% would be expected by chance). Simultaneously, the decoding of the power envelope of an auditory stimulus resulted in an average correlation coefficient of 0.37 between the actual and decoded power envelopes. These decoders were trained separately and executed simultaneously in real time. This study yielded the first demonstration that it is possible to decode simultaneously the functional activity of multiple independent brain systems. Our comparison of univariate and multivariate decoding strategies, and our analysis of the influence of their decoding parameters, provides benchmarks and guidelines for future research on this topic.

Simultaneous Real-Time Monitoring of Multiple Cortical Systems

PubMed Central

Gupta, Disha; Hill, N. Jeremy; Brunner, Peter; Gunduz, Aysegul; Ritaccio, Anthony L.; Schalk, Gerwin

2014-01-01

Objective Real-time monitoring of the brain is potentially valuable for performance monitoring, communication, training or rehabilitation. In natural situations, the brain performs a complex mix of various sensory, motor, or cognitive functions. Thus, real-time brain monitoring would be most valuable if (a) it could decode information from multiple brain systems simultaneously, and (b) this decoding of each brain system were robust to variations in the activity of other (unrelated) brain systems. Previous studies showed that it is possible to decode some information from different brain systems in retrospect and/or in isolation. In our study, we set out to determine whether it is possible to simultaneously decode important information about a user from different brain systems in real time, and to evaluate the impact of concurrent activity in different brain systems on decoding performance. Approach We study these questions using electrocorticographic (ECoG) signals recorded in humans. We first document procedures for generating stable decoding models given little training data, and then report their use for offline and for real-time decoding from 12 subjects (6 for offline parameter optimization, 6 for online experimentation). The subjects engage in tasks that involve movement intention, movement execution and auditory functions, separately, and then simultaneously. Main results Our real-time results demonstrate that our system can identify intention and movement periods in single trials with an accuracy of 80.4% and 86.8%, respectively (where 50% would be expected by chance). Simultaneously, the decoding of the power envelope of an auditory stimulus resulted in an average correlation coefficient of 0.37 between the actual and decoded power envelope. These decoders were trained separately and executed simultaneously in real time. Significance This study yielded the first demonstration that it is possible to decode simultaneously the functional activity of multiple independent brain systems. Our comparison of univariate and multivariate decoding strategies, and our analysis of the influence of their decoding parameters, provides benchmarks and guidelines for future research on this topic. PMID:25080161

Layout Study and Application of Mobile App Recommendation Approach Based On Spark Streaming Framework

NASA Astrophysics Data System (ADS)

Wang, H. T.; Chen, T. T.; Yan, C.; Pan, H.

2018-05-01

For App recommended areas of mobile phone software, made while using conduct App application recommended combined weighted Slope One algorithm collaborative filtering algorithm items based on further improvement of the traditional collaborative filtering algorithm in cold start, data matrix sparseness and other issues, will recommend Spark stasis parallel algorithm platform, the introduction of real-time streaming streaming real-time computing framework to improve real-time software applications recommended.

FPGA Based "Intelligent Tap" Device for Real-Time Ethernet Network Monitoring

NASA Astrophysics Data System (ADS)

Cupek, Rafał; Piękoś, Piotr; Poczobutt, Marcin; Ziębiński, Adam

This paper describes an "Intelligent Tap" - hardware device dedicated to support real-time Ethernet networks monitoring. Presented solution was created as a student project realized in Institute of Informatics, Silesian University of Technology with support from Softing A.G company. Authors provide description of realized FPGA based "Intelligent Tap" architecture dedicated for Real-Time Ethernet network monitoring systems. The practical device realization and feasibility study conclusions are presented also.

Pregnancy rates of beef cattle are not affected by Campylobacter fetus subsp. venerealis real-time PCR-positive breeding sires in New Zealand.

PubMed

Sanhueza, J M; Heuer, C; Jackson, R; Hughes, P; Anderson, P; Kelly, K; Walker, G

2014-09-01

Campylobacter fetus subspecies venerealis (C. fetus venerealis) is the causal agent of bovine genital campylobacteriosis, a venereal disease that is asymptomatic in bulls but responsible for reproductive wastage in female cattle. In New Zealand, a commercial real-time PCR assay was introduced in 2007 to identify the DNA of this pathogen in preputial scrapings; however, concerns were raised about the specificity of the test following anecdotal reports of a high number of test-positive bulls with no apparent relationship to reproductive performance. The objective of this study, therefore, was to examine the association between real-time PCR assay results from beef breeding bulls and pregnancy rates in beef herds using these bulls. Veterinarians from four veterinary practices selected beef cattle herds with relatively high and low pregnancy rates between December 2008 and February 2009. Preputial scrapings were collected from bulls used for mating in those herds. Samples were tested using the real-time PCR assay under consideration. Bivariable and multivariable analyses were used to assess the relationship between pregnancy rates in each mob (15-month-old heifers, 27-month-old heifers and mixed-age cows) and the percentage of real-time PCR-positive bulls in each mob. Sixty-four (28.8%) of 222 bulls tested positive, 130 (58.6%) tested negative, and 28 (12.6%) returned an inconclusive result to the real-time PCR assay. The percentage of bulls testing real-time PCR-positive in these mobs was not associated with pregnancy rates (p=0.757) after controlling for mob, average body condition score of cows, cow to bull ratio, length of the mating period, and farm. Real-time PCR assay results were not associated with pregnancy rates, suggesting that the specificity of the real-time PCR assay was too low to be used to reliably detect C. fetus venerealis. This study adds to a growing body of evidence indicating that C. fetus venerealis strains are either absent from, or present at clinically insignificant levels of endemicity among, beef breeding herds in New Zealand. The real-time PCR assay that was assessed in this study should not be used for the detection of C. fetus venerealis in bulls or for investigations of low conception rates in cattle in New Zealand. During the course of this survey, sequencing analysis of an apparent C. fetus venerealis isolate from the intestines of a Friesian bull turned out to be Campylobacter hyointestinalis. As a consequence, this real-time PCR assay for C. fetus venerealis is no longer being offered by diagnostic laboratories in New Zealand.

Real Time Metrics and Analysis of Integrated Arrival, Departure, and Surface Operations

NASA Technical Reports Server (NTRS)

Sharma, Shivanjli; Fergus, John

2017-01-01

A real time dashboard was developed in order to inform and present users notifications and integrated information regarding airport surface operations. The dashboard is a supplement to capabilities and tools that incorporate arrival, departure, and surface air-traffic operations concepts in a NextGen environment. As trajectory-based departure scheduling and collaborative decision making tools are introduced in order to reduce delays and uncertainties in taxi and climb operations across the National Airspace System, users across a number of roles benefit from a real time system that enables common situational awareness. In addition to shared situational awareness the dashboard offers the ability to compute real time metrics and analysis to inform users about capacity, predictability, and efficiency of the system as a whole. This paper describes the architecture of the real time dashboard as well as an initial set of metrics computed on operational data. The potential impact of the real time dashboard is studied at the site identified for initial deployment and demonstration in 2017; Charlotte-Douglas International Airport. Analysis and metrics computed in real time illustrate the opportunity to provide common situational awareness and inform users of metrics across delay, throughput, taxi time, and airport capacity. In addition, common awareness of delays and the impact of takeoff and departure restrictions stemming from traffic flow management initiatives are explored. The potential of the real time tool to inform the predictability and efficiency of using a trajectory-based departure scheduling system is also discussed.

Data-driven reinforcement learning–based real-time energy management system for plug-in hybrid electric vehicles

DOE PAGES

Qi, Xuewei; Wu, Guoyuan; Boriboonsomsin, Kanok; ...

2016-01-01

Plug-in hybrid electric vehicles (PHEVs) show great promise in reducing transportation-related fossil fuel consumption and greenhouse gas emissions. Designing an efficient energy management system (EMS) for PHEVs to achieve better fuel economy has been an active research topic for decades. Most of the advanced systems rely either on a priori knowledge of future driving conditions to achieve the optimal but not real-time solution (e.g., using a dynamic programming strategy) or on only current driving situations to achieve a real-time but nonoptimal solution (e.g., rule-based strategy). This paper proposes a reinforcement learning–based real-time EMS for PHEVs to address the trade-off betweenmore » real-time performance and optimal energy savings. The proposed model can optimize the power-split control in real time while learning the optimal decisions from historical driving cycles. Here, a case study on a real-world commute trip shows that about a 12% fuel saving can be achieved without considering charging opportunities; further, an 8% fuel saving can be achieved when charging opportunities are considered, compared with the standard binary mode control strategy.« less

Data-driven reinforcement learning–based real-time energy management system for plug-in hybrid electric vehicles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Qi, Xuewei; Wu, Guoyuan; Boriboonsomsin, Kanok

Plug-in hybrid electric vehicles (PHEVs) show great promise in reducing transportation-related fossil fuel consumption and greenhouse gas emissions. Designing an efficient energy management system (EMS) for PHEVs to achieve better fuel economy has been an active research topic for decades. Most of the advanced systems rely either on a priori knowledge of future driving conditions to achieve the optimal but not real-time solution (e.g., using a dynamic programming strategy) or on only current driving situations to achieve a real-time but nonoptimal solution (e.g., rule-based strategy). This paper proposes a reinforcement learning–based real-time EMS for PHEVs to address the trade-off betweenmore » real-time performance and optimal energy savings. The proposed model can optimize the power-split control in real time while learning the optimal decisions from historical driving cycles. Here, a case study on a real-world commute trip shows that about a 12% fuel saving can be achieved without considering charging opportunities; further, an 8% fuel saving can be achieved when charging opportunities are considered, compared with the standard binary mode control strategy.« less

An experimental study on real time bus arrival time prediction with GPS data

DOT National Transportation Integrated Search

2001-01-01

Bus headway in a rural area is usually much larger than that in an urban area. Providing real-time bus : arrival information could make the public transit system more user-friendly and thus enhance its : competitiveness among various transportation m...

An experimental study on real time bus arrival time prediction with GPS data

DOT National Transportation Integrated Search

1999-01-01

Bus headway in a rural area usually is much larger than that in an urban area. Providing real-time bus arrival information could make the public transit system more user-friendly and thus enhance its competitiveness among various transportation modes...

Post-processing method to reduce noise while preserving high time resolution in aethalometer real-time black carbon data

EPA Science Inventory

Real-time aerosol black carbon (BC) data, presented at time resolutions on the order of seconds to minutes, is desirable in field and source characterization studies measuring rapidly varying concentrations of BC. The Optimized Noise-reduction Averaging (ONA) algorithm has been d...

Capability of a Mobile Monitoring System to Provide Real-Time Data Broadcasting and Near Real-Time Source Attribution

NASA Astrophysics Data System (ADS)

Erickson, M.; Olaguer, J.; Wijesinghe, A.; Colvin, J.; Neish, B.; Williams, J.

2014-12-01

It is becoming increasingly important to understand the emissions and health effects of industrial facilities. Many areas have no or limited sustained monitoring capabilities, making it difficult to quantify the major pollution sources affecting human health, especially in fence line communities. Developments in real-time monitoring and micro-scale modeling offer unique ways to tackle these complex issues. This presentation will demonstrate the capability of coupling real-time observations with micro-scale modeling to provide real-time information and near real-time source attribution. The Houston Advanced Research Center constructed the Mobile Acquisition of Real-time Concentrations (MARC) laboratory. MARC consists of a Ford E-350 passenger van outfitted with a Proton Transfer Reaction Mass Spectrometer (PTR-MS) and meteorological equipment. This allows for the fast measurement of various VOCs important to air quality. The data recorded from the van is uploaded to an off-site database and the information is broadcast to a website in real-time. This provides for off-site monitoring of MARC's observations, which allows off-site personnel to provide immediate input to the MARC operators on how to best achieve project objectives. The information stored in the database can also be used to provide near real-time source attribution. An inverse model has been used to ascertain the amount, location, and timing of emissions based on MARC measurements in the vicinity of industrial sites. The inverse model is based on a 3D micro-scale Eulerian forward and adjoint air quality model known as the HARC model. The HARC model uses output from the Quick Urban and Industrial Complex (QUIC) wind model and requires a 3D digital model of the monitored facility based on lidar or industrial permit data. MARC is one of the instrument platforms deployed during the 2014 Benzene and other Toxics Exposure Study (BEE-TEX) in Houston, TX. The main goal of the study is to quantify and explain the origin of ambient exposure to hazardous air pollutants in an industrial fence line community near the Houston Ship Channel. Preliminary results derived from analysis of MARC observations during the BEE-TEX experiment will be presented.